title: Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome.
abstract: Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound from thehydroxycinnamic acid family. This polyphenol possesses many health-promoting properties, mostof them related to the treatment of metabolic syndrome, including anti-oxidant, anti-inflammatory,antilipidemic, antidiabetic, and antihypertensive activities. The first part of this review will discussthe role of chlorogenic acid as a nutraceutical for the prevention and treatment of metabolicsyndrome and associated disorders, including in vivo studies, clinical trials, and mechanisms ofaction. The second part of the review will be dealing with the role of chlorogenic acid as a foodadditive. Chlorogenic acid has shown antimicrobial activity against a wide range of organisms,including bacteria, yeasts, molds, viruses, and amoebas. These antimicrobial properties can beuseful for the food industry in its constant search for new and natural molecules for thepreservation of food products. In addition, chlorogenic acid has antioxidant activity, particularlyagainst lipid oxidation; protective properties against degradation of other bioactive compoundspresent in food, and prebiotic activity. The combination of these properties makes chlorogenic acidan excellent candidate for the formulation of dietary supplements and functional foods.
authors.affiliation: Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnología FEMSA, Av. Eugenio Garza Sada 2501 Sur, C.P. 64849 Monterrey, Mexico. jsantanag2000@gmail.com.
authors.forename: Jesús
authors.initials: J
authors.lastname: Santana-Gálvez
authors.affiliation: Department of Horticultural Sciences, Texas A&M University, College Station, TX 77843-2133, USA. lcisnero@tamu.edu.
authors.forename: Luis
authors.initials: L
authors.lastname: Cisneros-Zevallos
authors.affiliation: Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnología FEMSA, Av. Eugenio Garza Sada 2501 Sur, C.P. 64849 Monterrey, Mexico. djacobov@itesm.mx.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Jacobo-Velázquez
mesh_terms: D000818:Animals; D002726:Chlorogenic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005503:Food Additives / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D024821:Metabolic Syndrome / Q000178:diet therapy* / Q000517:prevention & control; D011801:Quinic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D002726:Chlorogenic Acid; D005503:Food Additives; D011801:Quinic Acid; C473200:5-caffeoylquinic acid
keywords: 5-O-caffeoylquinic acid; antibiotic; antioxidant; chlorogenic acid; metabolic syndrome; prebiotic