title: Association of TagSNP in lncRNA HOTAIR with susceptibility to noise-induced hearing loss in a Chinese population.
abstract: Noise-induced hearing loss (NIHL) is a multifactorial disease, and dysregulation of oxidative stress is universally acknowledged as one crucial pathogenic factor for this disease. Recently studies have found the LncRNA HOTAIR is involved in the alteration of oxidative stress level, cell proliferation, cell cycle progression, and apoptosis. Considering the effects of lncRNA HOTAIR in cellular oxidative stress, we sought to investigate the influence of lncRNA HOTAIR variants on the risk of NIHL.
  
  
  
  To explore the effects of HOTAIR polymorphisms on individual susceptibility to NIHL, We performed genotyping of three tagSNPs (rs874945, rs4759314 and rs7958904) in HOTAIR gene in a Chinese population which consists of 570 NIHL cases and 570 controls. The luciferase assays were further performed to investigate the regulatory function of HOTAIR tagSNPs.
  
  
  
  Our results revealed individuals with the G allele of HOTAIR tagSNP rs4759314 and the haplotype (rs874945, rs4759314 and rs7958904) are associated with an increased risk of NIHL in a Chinese population. Meanwhile, the rs4759314 G allele could significantly increase the expression of lncRNA HOTAIR.
  
  
  
  The genetic polymorphism within HOTAIR gene may play a crucial role in the occurrence and development of NIHL.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Nantong University, Nantong, Jiangsu, China; Department of Prevention and Control for Occupational Disease, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
authors.forename: Boshen
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Prevention and Control for Occupational Disease, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Enmin
authors.initials: E
authors.lastname: Ding
authors.affiliation: Kunshan Municipal Center for Disease Prevention and Control, Kunshan, Jiangsu, China.
authors.forename: Huanxi
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Prevention and Control for Occupational Disease, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Public Health Sciences, University of North Carolina Charlotte, Charlotte, NC, USA.
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.affiliation: Department of Emergency Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Prevention and Control for Occupational Disease, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Prevention and Control for Occupational Disease, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
authors.forename: Hengdong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Prevention and Control for Occupational Disease, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China. Electronic address: zhbl5888@sina.com.
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Department of Prevention and Control for Occupational Disease, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China; Department of Pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou, Jiangsu, China. Electronic address: sosolou@126.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000818:Animals; D044466:Asian People / Q000235:genetics; D001309:Auditory Threshold; D016022:Case-Control Studies; D002460:Cell Line; D002681:China; D005260:Female; D005786:Gene Expression Regulation; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006309:Hearing / Q000235:genetics*; D006317:Hearing Loss, Noise-Induced / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D006320:Hearing Tests; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D062085:RNA, Long Noncoding / Q000235:genetics*; D014162:Transfection
chemical_list: C561566:HOTAIR long untranslated RNA, human; D062085:RNA, Long Noncoding
keywords: Haploview; NIHL; Polymorphism; lncRNA HOTAIR; tagSNP