title: Enhanced depth imaging optical coherence tomography in patients with different phases of Behcet's panuveitis.
abstract: OBJECTIVE
  To evaluate the changes in choroidal thickness (CT) at 13 different points between "active," "remission," and "end-stage" phase of Behcet's panuveitis and compare this with the age, sex, and spherical equivalent matched healthy controls using enhanced depth imaging optical coherence tomography.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Eighty-five eyes of 45 patients with Behcet's panuveitis (19 eyes with active phase, 48 eyes with remission phase, and 18 eyes with end-stage phase) and 84 eyes of 42 controls were enrolled in this study.
  
  
  METHODS
  CT measurements were obtained beneath the fovea and at 500-µm intervals for 3 mm nasal and temporal to the centre of the fovea. Correlation analyses were calculated to assess the relationship of the CT with age and disease duration.
  
  
  RESULTS
  At all 13 measurement points, CT was significantly thinnest in end-stage-phase eyes and thickest in active-phase eyes (p < 0.01). CT was thicker in remission-phase eyes compared with control eyes at foveal and perifoveal points, but the trend was not statistically significant. The mean CT at each of the 13 measured points showed a negative correlation with age and disease duration (p < 0.01).
  
  
  CONCLUSIONS
  Submacular CT, as measured by enhanced depth imaging optical coherence tomography, was significantly reduced in eyes with Behcet's panuveitis in the end-stage phase and increased in those in the active phase.
authors.affiliation: Department of Ophthalmology, Baskent University, Faculty of Medicine, Ankara, Turkey; University of Miami Miller School of Medicine, Bascom Palmer Eye Institute, Miami, Florida. Electronic address: nxy28@med.miami.edu.
authors.forename: Nilufer
authors.initials: N
authors.lastname: Yesilirmak
authors.affiliation: University of Miami Miller School of Medicine, Bascom Palmer Eye Institute, Miami, Florida.
authors.forename: Wen-Hsiang
authors.initials: WH
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Baskent University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Sirel
authors.initials: S
authors.lastname: Gur Gungor
authors.affiliation: Department of Ophthalmology, Baskent University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Eylem
authors.initials: E
authors.lastname: Yaman Pinarci
authors.affiliation: Department of Ophthalmology, Baskent University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Imren
authors.initials: I
authors.lastname: Akkoyun
authors.affiliation: Department of Ophthalmology, Baskent University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Gursel
authors.initials: G
authors.lastname: Yilmaz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001528:Behcet Syndrome / Q000175:diagnosis*; D002648:Child; D002829:Choroid / Q000033:anatomy & histology*; D003430:Cross-Sectional Studies; D005260:Female; D005584:Fovea Centralis / Q000000981:diagnostic imaging*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D015864:Panuveitis / Q000175:diagnosis*; D011446:Prospective Studies; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult