title: Patient-specific computational modeling of cortical spreading depression via diffusion tensor imaging.
abstract: Cortical spreading depression, a depolarization wave originating in the visual cortex and traveling towards the frontal lobe, is commonly accepted as a correlate of migraine visual aura. As of today, little is known about the mechanisms that can trigger or stop such phenomenon. However, the complex and highly individual characteristics of the brain cortex suggest that the geometry might have a significant impact in supporting or contrasting the propagation of cortical spreading depression. Accurate patient-specific computational models are fundamental to cope with the high variability in cortical geometries among individuals, but also with the conduction anisotropy induced in a given cortex by the complex neuronal organisation in the grey matter. In this paper, we integrate a distributed model for extracellular potassium concentration with patient-specific diffusivity tensors derived locally from diffusion tensor imaging data.
authors.affiliation: Basque Center for Applied Mathematics, Bilbao, Spain.
authors.forename: Julia M
authors.identifier: 0000-0002-7067-5623
authors.initials: JM
authors.lastname: Kroos
authors.affiliation: Basque Center for Applied Mathematics, Bilbao, Spain.
authors.forename: Isabella
authors.initials: I
authors.lastname: Marinelli
authors.affiliation: Comp. Neuroimaging Lab, BioCruces Health Research Institute, Cruces University Hospital, Barakaldo, Spain.
authors.forename: Ibai
authors.initials: I
authors.lastname: Diez
authors.affiliation: Comp. Neuroimaging Lab, BioCruces Health Research Institute, Cruces University Hospital, Barakaldo, Spain.|Ikerbasque: The Basque Foundation for Science, Bilbao, Spain.|Department of Cell Biology and Histology, University of the Basque Country (UPV/EHU), Leioa, Spain.
authors.forename: Jesus M
authors.initials: JM
authors.lastname: Cortes
authors.affiliation: Basque Center for Applied Mathematics, Bilbao, Spain.|Dipartimento di Fisica, Universita di Bari, Italy.|INFN, Sezione di Bari, Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Stramaglia
authors.affiliation: Basque Center for Applied Mathematics, Bilbao, Spain.
authors.forename: Luca
authors.initials: L
authors.lastname: Gerardo-Giorda
mesh_terms: D013181:Cortical Spreading Depression; D056324:Diffusion Tensor Imaging; D006801:Humans; D066230:Patient-Specific Modeling; D014793:Visual Cortex / Q000000981:diagnostic imaging / Q000502:physiology*
keywords: cortical spreading depression; diffusion tensor imaging; finite element simulation; patient-specific cortical geometry; reaction-diffusion systems