title: The current status of human laryngeal transplantation in 2017: A state of the field review.
abstract: Human laryngeal allotransplantation has long been contemplated as a surgical option following laryngectomy, but there is a paucity of information regarding the indications, surgical procedure, and patient outcomes. Our objectives were to identify all human laryngeal allotransplants that have been undertaken and reported in the English literature and to evaluate the success of the procedure.
  
  
  
  MEDLINE, Embase, Current Index to Nursing and Allied Health Literature, Web of Science and Scopus, and the Gray literature.
  
  
  
  A comprehensive search strategy was undertaken across multiple databases. Inclusion criteria were case reports of patients who had undergone human laryngeal allotransplantation. Information regarding indications, operative techniques, complications, graft viability, and functional outcomes were extracted.
  
  
  
  A total of 5,961 articles, following removal of duplicates, matched the search criteria and were screened, with five case reports relating to two patients, ultimately fulfilling the entry criteria.
  
  
  
  Two laryngeal transplants have been reported in the medical literature. Although both patients report improved quality of life relating to their ability to communicate with voice, further research is necessary to shape our understanding of this complicated operation, its indications, and its functional outcomes. Laryngoscope, 127:1861-1868, 2017.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Giri
authors.identifier: 0000-0002-4196-9155
authors.initials: G
authors.lastname: Krishnan
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Charles
authors.initials: C
authors.lastname: Du
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, UCL Ear Institute, University College London, London, United Kingdom.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Fishman
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Foreman
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Phoenix, Arizona, U.S.A.
authors.forename: David G
authors.initials: DG
authors.lastname: Lott
authors.affiliation: Department of Otolaryngology, Division of Head and Neck Surgery, University of California Davis, Sacramento, California, U.S.A.
authors.forename: Gregory
authors.initials: G
authors.lastname: Farwell
authors.affiliation: Department of Otolaryngology, Division of Head and Neck Surgery, University of California Davis, Sacramento, California, U.S.A.
authors.forename: Peter
authors.initials: P
authors.lastname: Belafsky
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Suren
authors.initials: S
authors.lastname: Krishnan
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, UCL Ear Institute, University College London, London, United Kingdom.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Birchall
mesh_terms: D006801:Humans; D007830:Larynx / Q000637:transplantation*; D016896:Treatment Outcome
keywords: Larynx; transplant recipients; transplantation