title: FeTPPS Reduces Secondary Damage and Improves Neurobehavioral Functions after Traumatic Brain Injury.
abstract: Traumatic brain injury (TBI) determinate a cascade of events that rapidly lead to neuron's damage and death. We already reported that administration of FeTPPS, a 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrin iron III chloride peroxynitrite decomposition catalyst, possessed evident neuroprotective effects in a experimental model of spinal cord damage. The present study evaluated the neuroprotective property of FeTPPS in TBI, using a clinically validated model of TBI, the controlled cortical impact injury (CCI). We observe that treatment with FeTPPS (30 mg/kg, i.p.) reduced: the state of brain inflammation and the tissue hurt (histological score), myeloperoxidase activity, nitric oxide production, glial fibrillary acidic protein (GFAP) and pro-inflammatory cytokines expression and apoptosis process. Moreover, treatment with FeTPPS re-established motor-cognitive function after CCI and it resulted in a reduction of lesion volumes. Our results established that FeTPPS treatment decreases the growth of inflammatory process and the tissue injury associated with TBI. Thus our study confirmed the neuroprotective role of FeTPPS treatment on TBI.
authors.affiliation: Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Messina, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bruschetta
authors.affiliation: Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Messina, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Impellizzeri
authors.affiliation: Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Messina, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Campolo
authors.affiliation: Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Messina, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Casili
authors.affiliation: Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Messina, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Di Paola
authors.affiliation: Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Messina, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Paterniti
authors.affiliation: Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Messina, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Esposito
authors.affiliation: Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaMessina, Italy; Department of Pharmacological and Physiological Science, Saint Louis University School of MedicineSt. Louis. MO, USA.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cuzzocrea
keywords: apoptosis; cortical impact; inflammation; peroxynitrite; reactive oxygen species