title: Molecular Imaging in Neuroendocrine Differentiation of Prostate Cancer: 68Ga-PSMA Versus 68Ga-DOTA NOC PET-CT.
abstract: We report on a 62-year-old man with metastatic prostate cancer (cT3b N1) diagnosed in 2011, treated with total androgen blockage with flutamide and goserelin acetate (Zoladex). He presented with left suprascapular swelling and low-back pain after being asymptomatic for 5 years. His prostate-specific antigen was 0.049 ng/mL. F-NaF PET-CT and Ga-PSMA scan were negative, whereas Ga-DOTA NOC scan done after 10 days showed multiple somatostatin-avid hepatic and lymph node metastasis.
authors.affiliation: From the *Department of Nuclear Medicine, Kuwait Cancer Control Center (KCCC), Khaitan, Kuwait; and †Jack Brignall PET/CT Centre, Castle Hill Hosptial, Cottingham, United Kingdom.
authors.forename: Sharjeel
authors.initials: S
authors.lastname: Usmani
authors.forename: Najeeb
authors.initials: N
authors.lastname: Ahmed
authors.forename: Fahad
authors.initials: F
authors.lastname: Marafi
authors.forename: Rashid
authors.initials: R
authors.lastname: Rasheed
authors.forename: Henney G
authors.initials: HG
authors.lastname: Amanguno
authors.forename: Fareeda
authors.initials: F
authors.lastname: Al Kandari
mesh_terms: D004492:Edetic Acid / Q000031:analogs & derivatives; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging* / Q000556:secondary; D009842:Oligopeptides; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D019275:Radiopharmaceuticals; D012969:Sodium Fluoride
chemical_list: C504894:68Ga-DOTANOC; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; D012969:Sodium Fluoride; D004492:Edetic Acid