title: Continuous Intravenous Milrinone Therapy in Pediatric Outpatients.
abstract: Milrinone is a phosphodiesterase 3 inhibitor with both positive inotropic and vasodilator properties. Administered as a continuous infusion, milrinone is indicated for the short-term treatment of patients with acute decompensated heart failure. Despite limited data supporting long-term milrinone therapy in adults with congestive heart failure, children managed as outpatients may benefit from continuous milrinone as a treatment for cardiac dysfunction, as a destination therapy for cardiac transplant, or as palliative therapy for cardiomyopathy. The aim of this article is to review the medical literature and describe a home infusion company's experience with pediatric outpatient milrinone therapy.
authors.affiliation: Pediatric Home Service (Ms Curley and Dr Liebers), and Children's Hospitals and Clinics of Minnesota (Dr Maynard). Michelle Curley, RN, CRNI®, is an infusion nurse manager at Pediatric Home Service, Roseville, MN. Jill Liebers, PharmD, is a pharmacy manager at Pediatric Home Service, Roseville, MN. Roy Maynard, MD, is a practicing pediatric pulmonologist on staff at Children's Hospitals and Clinics of Minnesota, Minneapolis, MN. He is also the medical director at Pediatric Home Service, Roseville, MN.
authors.forename: Michelle
authors.initials: M
authors.lastname: Curley
authors.forename: Jill
authors.initials: J
authors.lastname: Liebers
authors.forename: Roy
authors.initials: R
authors.lastname: Maynard
mesh_terms: D000293:Adolescent; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006333:Heart Failure / Q000188:drug therapy; D016027:Heart Transplantation; D006439:Hemodynamics / Q000187:drug effects; D018718:Home Infusion Therapy / Q000379:methods* / Q000451:nursing; D006701:Home Nursing; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D020105:Milrinone / Q000627:therapeutic use*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D002316:Cardiotonic Agents; D020105:Milrinone