title: The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures.
abstract: This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician-directed fashion.
authors.affiliation: Division of Interventional Radiology, Department of Radiology, Koç University School of Medicine, Istanbul, Turkey.
authors.forename: Alan Alper
authors.initials: AA
authors.lastname: Sag
authors.affiliation: School of Medicine, Koç University, Istanbul, Turkey.
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Sal
authors.affiliation: School of Medicine, Koç University, Istanbul, Turkey.
authors.forename: Yagmur
authors.initials: Y
authors.lastname: Kilic
authors.affiliation: School of Medicine, Koç University, Istanbul, Turkey.
authors.forename: Emine Meltem
authors.initials: EM
authors.lastname: Onal
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Koç University School of Medicine, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanbay
mesh_terms: D057225:Data Mining / Q000379:methods*; D059290:Dopaminergic Neurons / Q000187:drug effects; D004351:Drug Resistance; D004626:Embryology; D000075222:Essential Hypertension / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000294:innervation / Q000503:physiopathology / Q000601:surgery; D062346:Molecular Medicine / Q000379:methods*; D038081:Organogenesis; D049971:Thiazides / Q000627:therapeutic use; D017211:Treatment Failure; D014212:Tretinoin / Q000378:metabolism
chemical_list: D049971:Thiazides; D014212:Tretinoin
keywords: denervation; hypertension resistant to conventional therapy; hypertension, essential; radiology, interventional