title: Association between the plasma levels of IMA and coronary atherosclerotic plaque burden and ischemic burden in early phase of non-ST-segment-elevation acute coronary syndromes.
abstract: Ischemia-modified albumin (IMA), a novel biochemical marker, is known to reflect ischemia in early phases of acute coronary syndrome (ACS). In the present study, we evaluated the role of IMA on the prediction of coronary atherosclerotic plaque burden and ischemic burden in patients with non-ST-segment-elevation acute coronary syndromes (NSTEACS).
  
  
  
  Ninety-six consecutive NSTEACS patients presented within the first three hours of symptom onset were prospectively enrolled in this study. Blood samples were collected in the first 30 min of admission for IMA measurement. Serum levels of IMA were analyzed using the rapid and colorimetric method and reported in absorbance units (ABSU). Coronary plaque burden was assessed by using angiographic Gensini score (GS). In addition, patients were divided into large (LIBG) and small ischemic burden (SIBG) groups based on angiography findings.
  
  
  
  Patients were dichotomized into two groups according to median GS as follows; with GS ≤ 44 and GS > 44, respectively. Mean IMA was significantly higher in GS > 44 group as compared to GS ≤ 44 group (0.746 ± 0.15 vs. 0.550 ± 0.12 ABSU, p < 0.001). The GS was positively correlated with the levels of IMA (r = 0.673, p < 0.001). IMA was significantly higher in LIBG as compared to SIBG (0.745 ± 0.16 vs. 0.570 ± 0.13 ABSU, p < 0.001).
  
  
  
  IMA measurement in early phases of NSTEACS may give predictive information about ischemic burden and coronary atherosclerotic plaque burden; thus, may be useful in decision-making about treatment options in these patients.
authors.affiliation: Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey. drtt61@gmail.com.
authors.forename: T
authors.initials: T
authors.lastname: Turan
authors.forename: A R
authors.initials: AR
authors.lastname: Akyüz
authors.forename: S
authors.initials: S
authors.lastname: Sahin
authors.forename: S
authors.initials: S
authors.lastname: Kul
authors.forename: A S
authors.initials: AS
authors.lastname: Yilmaz
authors.forename: F
authors.initials: F
authors.lastname: Kara
authors.forename: S O
authors.initials: SO
authors.lastname: Mentese
authors.forename: A Ç
authors.initials: AÇ
authors.lastname: Aykan
authors.forename: S
authors.initials: S
authors.lastname: Demir
authors.forename: S
authors.initials: S
authors.lastname: Celik
authors.forename: S C
authors.initials: SC
authors.lastname: Karahan
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood*; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D012709:Serum Albumin; D000075462:Serum Albumin, Human
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human