title: Comparison of 270 Versus 320 mg I/mL of Iodixanol in 1 Image Assessment of Both Renal Arteries and Veins With Dual-Energy Spectral CT Imaging in Late Arterial Phase and Their Influence on Renal Function.
abstract: OBJECTIVE
  The objective of this study was to compare the image quality of renal arteries and veins with dual-energy spectral computed tomography (CT) imaging in late arterial phase using 270 and 320 mg I/mL of iodixanol and their influence on renal function.
  
  
  METHODS
  A total of 1062 patients underwent renal CT angiography with 270 or 320 mg I/mL of iodixanol with dual-energy spectral CT imaging in late arterial phase. Image quality and their influence on renal function were compared.
  
  
  RESULTS
  There were no significant differences of CT value, signal-to-noise ratio, contrast-to-noise ratio, and subjective score of renal vessels between 2 groups (all P > 0.05). The incidence of contrast-induced nephropathy in patients with abnormal renal function using 320 mg I/mL of iodixanol was significantly higher than using 270 mg I/mL of iodixanol (P = 0.043).
  
  
  CONCLUSIONS
  The renal arteries and veins can be fully assessed in late arterial phase with 270 mg I/mL of iodixanol using dual-energy spectral CT scan with better preserved renal function.
authors.affiliation: From the *Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University; Departments of †Radiology, and ‡Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Kefeng
authors.initials: K
authors.lastname: Zhou
authors.forename: Jian
authors.initials: J
authors.lastname: He
authors.forename: Feng
authors.initials: F
authors.lastname: Qu
authors.forename: Haijian
authors.initials: H
authors.lastname: Fan
authors.forename: Yi
authors.initials: Y
authors.lastname: Ma
authors.forename: Tingting
authors.initials: T
authors.lastname: Shi
authors.forename: Zhengyang
authors.initials: Z
authors.lastname: Zhou
authors.forename: Bin
authors.initials: B
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000072226:Computed Tomography Angiography / Q000379:methods*; D003287:Contrast Media / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D007677:Kidney Function Tests / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000379:methods*; D015900:Radiography, Dual-Energy Scanned Projection / Q000379:methods; D012077:Renal Artery / Q000000981:diagnostic imaging*; D059629:Signal-To-Noise Ratio; D014283:Triiodobenzoic Acids / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol