title: Cardiac Fibrosis in Aortic Stenosis and Hypertensive Heart Disease Assessed by Magnetic Resonance T1 Mapping.
abstract: Continuous pressure overload may lead to subclinical myocardial tissue changes in patients with hypertensive heart disease (HHD) and aortic stenosis (AS). The study aim was to detect interstitial fibrosis using quantitative cardiovascular magnetic resonance.
  
  
  
  Fifteen patients with HHD (arterial hypertension + septal wall thickness ≥13 mm), 33 with AS (eight mild, 15 moderate, 10 severe), and 60 healthy controls were enrolled. Native T1 maps (modified Look-Locker inversion recovery) were obtained in a basal, mid-ventricular, and apical shortaxis slice of the left ventricle to assess cardiac fibrosis. Focal fibrosis was assessed with late gadolinium enhancement (LGE).
  
  
  
  Patients with HHD and controls did not differ regarding the native myocardial T1 values, both per slice and per segment. In AS patients, apical native T1 values were lower than in controls, and there was a trend towards higher T1 values in the septum in severe AS (1172.6 ± 62.0 ms versus 1152.9 ± 43.9 ms). Five HHD patients and 11 AS patients had non-ischemic fibrosis in LGE images. Native T1 times did not differ between LGE-positive and LGEnegative groups (both with inclusion and exclusion of segments with LGE).
  
  
  
  T1 mapping did not reveal any evidence of abnormal interstitial fibrosis in HHD subjects with mild hypertrophy. In severe AS, a trend towards more interstitial fibrosis was present, but absolute differences were small for decision making.
authors.affiliation: Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center and HELIOS Klinikum Berlin Buch, Department of Cardiology and Nephrology, Berlin, Germany. Electronic correspondence: florian.von-knobelsdorff@charite.de.
authors.forename: Florian
authors.initials: F
authors.lastname: von Knobelsdorff-Brenkenhoff
authors.affiliation: Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center and HELIOS Klinikum Berlin Buch, Department of Cardiology and Nephrology, Berlin, Germany.
authors.forename: Anna-Katharina
authors.initials: AK
authors.lastname: Mueller
authors.affiliation: Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center and HELIOS Klinikum Berlin Buch, Department of Cardiology and Nephrology, Berlin, Germany.
authors.forename: Marcel
authors.initials: M
authors.lastname: Prothmann
authors.affiliation: Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center and HELIOS Klinikum Berlin Buch, Department of Cardiology and Nephrology, Berlin, Germany.
authors.forename: Pierre
authors.initials: P
authors.lastname: Hennig
authors.affiliation: Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center and HELIOS Klinikum Berlin Buch, Department of Cardiology and Nephrology, Berlin, Germany.
authors.forename: Matthias A
authors.initials: MA
authors.lastname: Dieringer
authors.affiliation: Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center and HELIOS Klinikum Berlin Buch, Department of Cardiology and Nephrology, Berlin, Germany.
authors.forename: Luisa
authors.initials: L
authors.lastname: Schmacht
authors.affiliation: Siemens Healthcare GmbH, Erlangen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Greiser
authors.affiliation: German Center for Cardiovascular Research (DZHK), partner site Berlin, Germany.
authors.forename: Jeanette
authors.initials: J
authors.lastname: Schulz-Menger
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005355:Fibrosis; D006321:Heart / Q000000981:diagnostic imaging; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*