title: Pulmonary toxicity after intraperitoneal mitomycin C: a case report of a rare complication of HIPEC.
abstract: BACKGROUND
  Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has become a common treatment approach for disseminated appendiceal neoplasms. Systemic absorption of intraperitoneal chemotherapeutics may lead to drug-induced toxicity, most commonly neutropenia. Mitomycin C has been the most commonly used chemotherapeutic in HIPEC for the past several decades.
  
  
  METHODS
  Here, we describe a rare pulmonary complication secondary to intraperitoneal administration of mitomycin C.
  
  
  CONCLUSIONS
  While rare, intraperitoneal mitomycin C has the potential to cause serious pulmonary toxicity that should be considered with administration. To our knowledge, this report represents only the second case described in the literature.
authors.affiliation: School of Medicine, Duke University Medical Center, Box 3247, Durham, NC, 27710, USA.
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Abel
authors.affiliation: Department of Surgery, Duke University Medical Center, Box 3247, Durham, NC, 27710, USA.
authors.forename: George
authors.initials: G
authors.lastname: Kokosis
authors.affiliation: Department of Surgery, Duke University Medical Center, Box 3247, Durham, NC, 27710, USA. trey.blazer@duke.edu.
authors.forename: Dan G
authors.initials: DG
authors.lastname: Blazer
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001063:Appendiceal Neoplasms / Q000556:secondary / Q000628:therapy*; D010478:Chemotherapy, Cancer, Regional Perfusion; D003131:Combined Modality Therapy / Q000009:adverse effects*; D065426:Cytoreduction Surgical Procedures / Q000009:adverse effects; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects; D007274:Injections, Intraperitoneal; D016685:Mitomycin / Q000009:adverse effects*; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000628:therapy*; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000473:pathology
chemical_list: D016685:Mitomycin
keywords: ARDS; Appendiceal cancer; Intraperitoneal chemotherapy; Mitomycin C; Pulmonary toxicity