title: [Correlation between cytochrome 3A4+894C>T P450 gene polymorphism and outcomes of coronary intervention in patients with acute coronary syndrome].
abstract: OBJECTIVE
  To investigate the relationship between plasma cytochrome P450 3A4 (CYP3A4) 894C>T gene polymorphism and the risk of recurrence of adverse cardiac events after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS).
  
  
  METHODS
  A total of 275 patients with ACS received standard dual antiplatelet therapy and PCI. Platelet aggregation rate (PAR) was detected in each patient before and 7 days after administration of the anti-platelet drugs. Single nucleotide polymorphism of CYP3A4 gene 894C>T was detected with PCR and microarray technique. The number of coronary artery lesions was determined by PCI and the Gensini score was calculated. The patients were followed up for 3-12 months after discharge.
  
  
  RESULTS
  No significant difference was found in CYP3A4 gene polymorphism between patients with clopidogrel resistance (CR group) and those without CR (NCR group) (P>0.05). Multivariate logistic regression analysis showed that CYP3A4 gene 894C>T polymorphism was not correlated with CR in patients with ACS (OR 1.359, P>0.05). During the follow-up, the incidence of cardiovascular events was significantly higher in CR group than in NCR group (P<0.05), but this difference was not related to the mutation type of 894C>T locus of CYP3A4 gene.
  
  
  CONCLUSIONS
  The CYP3A4 gene 894C>T polymorphism is not associated with the effect of anti-platelet therapy and the risk of cardiovascular event in patients with ACS following PCI.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China. E-mail: 839284494@qq.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Miao-Nan
authors.initials: MN
authors.lastname: Li
authors.forename: Pin-Fang
authors.initials: PF
authors.lastname: Kang
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Tang
authors.forename: Dong-Yu
authors.initials: DY
authors.lastname: Lu
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Shi
authors.forename: Hong-Ju
authors.initials: HJ
authors.lastname: Wang
mesh_terms: D054058:Acute Coronary Syndrome / Q000628:therapy*; D000483:Alleles; D001792:Blood Platelets; D000077144:Clopidogrel; D051544:Cytochrome P-450 CYP3A / Q000235:genetics*; D006801:Humans; D062645:Percutaneous Coronary Intervention; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010979:Platelet Function Tests; D020641:Polymorphism, Single Nucleotide; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D013988:Ticlopidine