title: Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+Detection and Selective On-Demand Photodynamic Therapy.
abstract: As a light-activated noninvasive cancer treatment paradigm, photodynamic therapy (PDT) has attracted extensive attention because of its high treatment efficacy and low side effects. Especially, spatiotemporal control of singlet oxygen (1O2) release is highly desirable for realizing on-demand PDT, which, however, still remains a huge challenge. To address this issue, a novel switchable near-infrared (NIR)-responsive upconversion nanoprobe has been designed and successfully applied for controlled PDT that can be optically activated by tumor-associated disruption of labile Zn2+(denoted as Zn2+hereafter) homeostasis stimuli. Upon NIR irradiation, this theranostic probe can not only quantitatively detect the intracellular endogenous Zn2+in situ but also selectively generate a great deal of cytotoxic reactive oxygen species (ROS) for efficiently killing breast cancer cells under the activation of excessive endogenous Zn2+, so as to maximally avoid adverse damage to normal cells. This study aims to propose a new tumor-specific PDT paradigm and, more importantly, provide a new avenue of thought for efficient cancer theranostics based on our designed highly sensitive upconversion nanoprobes.
authors.affiliation: Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University , Shanghai 200433, People's Republic of China.|State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Hu
authors.affiliation: Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University , Shanghai 200433, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University , Shanghai 200433, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University , Shanghai 200433, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Tongji University , Shanghai 200092, People's Republic of China.
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Institute of Materials Research and Engineering , 2 Fusionopolis Way, Singapore 138634.
authors.forename: Ming-Yong
authors.initials: MY
authors.lastname: Han
authors.affiliation: King Abdullah Institute for Nanotechnology, King Saud University , Riyadh 11451, Saudi Arabia.
authors.forename: Ahmed Mohamed
authors.initials: AM
authors.lastname: El-Toni
authors.affiliation: Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University , Shanghai 200433, People's Republic of China.
authors.forename: Dongyuan
authors.identifier: 0000-0001-8440-6902
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University , Shanghai 200433, People's Republic of China.
authors.forename: Fan
authors.identifier: 0000-0001-7886-6144
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D061986:MCF-7 Cells; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010778:Photochemotherapy; D017382:Reactive Oxygen Species / Q000378:metabolism; D013499:Surface Properties; D015032:Zinc / Q000032:analysis*
chemical_list: D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D017382:Reactive Oxygen Species; D015032:Zinc