title: Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents.
abstract: In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the referencesChloramphenicolandTrimethoprim/sulphamethoxazole. The antimicrobial results of the investigated compounds revealed promising results and some derivatives have activities similar to the references used.
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. s.m.gomha@gmail.com.
authors.forename: Sobhi M
authors.initials: SM
authors.lastname: Gomha
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. thoraya-f@hotmail.com.|Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah-Al-mukkarramah 21514, Saudi Arabia. thoraya-f@hotmail.com.
authors.forename: Thoraya A
authors.initials: TA
authors.lastname: Farghaly
authors.affiliation: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh-11451, Saudi Arabia. yahia@ksu.edu.sa.
authors.forename: Yahia Nasser
authors.initials: YN
authors.lastname: Mabkhot
authors.affiliation: Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah B.O. 208203, Saudi Arabia. mohiem@yahoo.com.
authors.forename: Mohie E M
authors.initials: ME
authors.lastname: Zayed
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. amaaniq21@yahoo.com.
authors.forename: Amany M G
authors.initials: AM
authors.lastname: Mohamed
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001393:Azoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D001393:Azoles; D011743:Pyrimidines
keywords: antimicrobial activity; microwave irradiation; pyrazoles; thiazoles; thiophenes