title: Radiation therapy for malignant pleural mesothelioma.
abstract: The treatment of malignant pleural mesothelioma with radiation has always been a technical challenge. For many years, conventional radiation therapy was delivered after extrapleural pneumonectomy with acceptable results. Novel radiation treatment techniques, such as intensity modulated radiation therapy (IMRT) were introduced, but the early experience with IMRT demonstrated troubling toxicity. Recent reports from institutions have demonstrated that with greater experience, IMRT, both in the setting of extrapleural pneumonectomy or pleurectomy, can be delivered safely. A recent study, SAKK 17/04, questions the role of using radiation after extrapleural pneumonectomy.
authors.affiliation: Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, One Gustav L. Levy Place, Box 1236, 10029 New York, NY, USA. Electronic address: Kenneth.rosenzweig@mountsinai.org.
authors.forename: K E
authors.initials: KE
authors.lastname: Rosenzweig
authors.affiliation: Service d'oncologie radiothérapie, hôpital européen Georges-Pompidou, université Paris Descartes, Sorbonne Paris Cité, 20, rue Leblanc, 75015 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Giraud
mesh_terms: D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003964:Diaphragm / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D008654:Mesothelioma / Q000532:radiotherapy* / Q000601:surgery; D000086002:Mesothelioma, Malignant; D020360:Neoadjuvant Therapy / Q000009:adverse effects / Q000379:methods; D010496:Pericardium / Q000601:surgery; D010994:Pleura / Q000601:surgery; D010997:Pleural Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D011013:Pneumonectomy / Q000379:methods; D017564:Radiation Pneumonitis / Q000209:etiology / Q000517:prevention & control; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome
keywords: Intensity modulated radiation therapy; Mesothelioma; Mésothéliome; Pneumopathie radique; Radiation pneumonitis; Radiotherapy; Radiothérapie; Radiothérapie conformationnelle avec modulation d’intensité