title: Pathogenicity of Conidiobolus coronatus and Fusarium solani in mouse models.
abstract: To study the pathogenicity of Conidiobolus coronatus (C. coronatus) and Fusarium solani (F. solani) in animal models. Immunocompromised mice were treated with cyclophosphamide and prednisolone via intraperitoneal injection before and after inoculation. According to pathogenic characteristics of different fungi, C. coronatus was used to infect mice via intravenous inoculation, intraperitoneal inoculation, gastrointestinal infusion and intradermal inoculation methods. And F. solani was used to infect mice by inoculation via the abraded or normal skin. In the group of immunocompromised mice, C. coronatus was isolated from the lung tissues of one mouse on day 7 and another on day 10 respectively. The corresponding histopathology revealed infiltration of local inflammatory cells in the lung tissue. Pathogenic lesions were observed in all normal and immunocompromised mice infected with F. solani via abraded skin. The lesions in the immunocompromised mice were more severe and persisted longer than those in the normal mice. Moreover, hyphae were mostly observed in the histopathological examination and fungal culture from the immunocompromised mouse. The pathogenicity of C. coronatus was relatively weak as it did not induce local infections and did not disseminate the disease in immunocompetent and immunocompromised mice. Therefore, F. solani is a type of opportunistic pathogenic fungus, and abraded skin is one of the causative routes of infection.
authors.affiliation: Department of Dermatology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Yadi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Dermatology, Weifang People's Hospital, Weifang, China.
authors.forename: Xiangang
authors.initials: X
authors.lastname: Fang
authors.affiliation: Department of Dermatology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Dermatology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Suying
authors.initials: S
authors.lastname: Geng
authors.affiliation: Department of Dermatology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Dermatology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Xiumin
authors.identifier: http://orcid.org/0000-0002-7644-1828
authors.initials: X
authors.lastname: Yang
mesh_terms: D000818:Animals; D020092:Conidiobolus / Q000187:drug effects / Q000472:pathogenicity*; D003520:Cyclophosphamide / Q000494:pharmacology; D004195:Disease Models, Animal; D060585:Fusariosis / Q000188:drug therapy / Q000473:pathology*; D005670:Fusarium / Q000187:drug effects / Q000472:pathogenicity*; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011239:Prednisolone / Q000494:pharmacology; D012867:Skin / Q000382:microbiology / Q000473:pathology; D020096:Zygomycosis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone
keywords: 
  Conidiobolus coronatus
  ; 
  Fusarium solani
  ; animal models; pathogenicity