title: Predictive Success Factors in Selective Upper Airway Stimulation.
abstract: Obstructive sleep apnea is one of the most common diseases in Western industrialized countries. A variety of conservative and surgical treatment options are available for its treatment. In recent years, selective upper airway stimulation (sUAS) has been shown to be effective and safe. Different biomarkers have been investigated as predictive clinical success factors in a number of clinical trials. Age does not matter in sUAS, as compared to its predictive role in other therapies. Weight seems to play a limited role, depending on drug-induced sleep endoscopy to rule out a complete concentric collapse with an increased body mass index. For surgical success and the related postoperative tongue motions, a nerve integrity monitoring methodology has been developed for predicting correct cuff placement. Postoperative sonography remains a promising method for the future assessment of predictive markers in sUAS.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Technische Universität München, Munich, Germany.
authors.forename: Clemens
authors.initials: C
authors.lastname: Heiser
authors.forename: Benedikt
authors.initials: B
authors.lastname: Hofauer
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000072700:Conservative Treatment / Q000379:methods; D004599:Electric Stimulation Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007002:Hypoglossal Nerve; D007828:Laryngoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D017286:Polysomnography / Q000379:methods; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D016896:Treatment Outcome