title: Association between Toxoplasma gondii seropositivity and memory function in nondemented older adults.
abstract: Toxoplasma gondii (T. gondii) seropositivity may be associated with decreased memory in older adults. To further investigate the association between T. gondii seropositivity and memory in nondemented older adults, we obtained serum samples from 114 nondemented older adults evaluated by the Alzheimer's Disease and Research Center at Washington University in St. Louis, Missouri, USA. We determined T. gondii seropositivity and anti-T. gondii IgG antibody titer and examined associations with memory function while controlling for socioeconomic status, education level, age, and apolipoprotein E4 status. There were few associations between T. gondii seropositivity or anti-T. gondii IgG antibodies and memory, although there was some support suggesting an interaction between anti-T. gondii and sex. In the seropositive-only sample, there was an inverse relationship between anti-T. gondii titer and performance on the selective reminding test. Overall, we found little evidence of an association between impaired memory function and T. gondii seropositivity and anti-T. gondii IgG antibodies in this sample of nondemented older adults.
authors.affiliation: Department of Psychology, Brigham Young University, Provo, UT, USA.
authors.forename: Cynthia P
authors.initials: CP
authors.lastname: Wyman
authors.affiliation: Department of Psychology, Brigham Young University, Provo, UT, USA; The Neuroscience Center, Brigham Young University, Provo, UT, USA. Electronic address: shawn_gale@byu.edu.
authors.forename: Shawn D
authors.initials: SD
authors.lastname: Gale
authors.affiliation: Department of Psychology, Brigham Young University, Provo, UT, USA.
authors.forename: Ariana
authors.initials: A
authors.lastname: Hedges-Muncy
authors.affiliation: Department of Sociology, Brigham Young University, Provo, UT, USA.
authors.forename: Lance D
authors.initials: LD
authors.lastname: Erickson
authors.affiliation: Department of Microbiology & Molecular Biology, Brigham Young University, Provo, UT, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Wilson
authors.affiliation: Department of Psychology, Brigham Young University, Provo, UT, USA; The Neuroscience Center, Brigham Young University, Provo, UT, USA.
authors.forename: Dawson W
authors.initials: DW
authors.lastname: Hedges
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology* / Q000523:psychology*; D000913:Antibodies, Protozoan / Q000097:blood*; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000209:etiology* / Q000523:psychology; D008875:Middle Aged; D009483:Neuropsychological Tests; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000150:complications / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan; D007074:Immunoglobulin G
keywords: Aging; Memory; Neurocognitive function; Toxoplasma gondii; Toxoplasmosis