title: Human airway trypsin-like protease, a serine protease involved in respiratory diseases.
abstract: More than 2% of all human genes are coding for a complex system of more than 700 proteases and protease inhibitors. Among them, serine proteases play extraordinary, diverse functions in different physiological and pathological processes. The human airway trypsin-like protease (HAT), also referred to as TMPRSS11D and serine 11D, belongs to the emerging family of cell surface proteolytic enzymes, the type II transmembrane serine proteases (TTSPs). Through the cleavage of its four major identified substrates, HAT triggers specific responses, notably in epithelial cells, within the pericellular and extracellular environment, including notably inflammatory cytokine production, inflammatory cell recruitment, or anticoagulant processes. This review summarizes the potential role of this recently described protease in mediating cell surface proteolytic events, to highlight the structural features, proteolytic activity, and regulation, including the expression profile of HAT, and discuss its possible roles in respiratory physiology and disease.
authors.affiliation: Inserm UMR1152, Medical School Xavier Bichat, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodeling) and LabEx Inflamex, Paris, France; and.
authors.forename: Awen
authors.initials: A
authors.lastname: Menou
authors.affiliation: Inserm UMR1152, Medical School Xavier Bichat, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodeling) and LabEx Inflamex, Paris, France; and.
authors.forename: JanWillem
authors.initials: J
authors.lastname: Duitman
authors.affiliation: Inserm UMR1152, Medical School Xavier Bichat, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodeling) and LabEx Inflamex, Paris, France; and.
authors.forename: Pauline
authors.initials: P
authors.lastname: Flajolet
authors.affiliation: Inserm UMR1152, Medical School Xavier Bichat, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodeling) and LabEx Inflamex, Paris, France; and.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Sallenave
authors.affiliation: Inserm UMR1152, Medical School Xavier Bichat, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodeling) and LabEx Inflamex, Paris, France; and.
authors.forename: Arnaud André
authors.initials: AA
authors.lastname: Mailleux
authors.affiliation: Inserm UMR1152, Medical School Xavier Bichat, Paris, France; bruno.crestani@aphp.fr.|Université Paris Diderot, Sorbonne Paris Cité, Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodeling) and LabEx Inflamex, Paris, France; and.|APHP, Hôpital Bichat, Service de Pneumologie A, Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Crestani
mesh_terms: D000818:Animals; D055162:Biocatalysis; D047109:Fetal Development; D006801:Humans; D008954:Models, Biological; D012120:Respiration Disorders / Q000196:embryology / Q000201:enzymology* / Q000473:pathology; D012697:Serine Endopeptidases / Q000737:chemistry / Q000378:metabolism*
chemical_list: D012697:Serine Endopeptidases; C112256:human airway trypsin-like protease
keywords: TMPRSS11D; human airway trypsin-like protease; protease activated receptor-2; serine protease; urokinase-type plasminogen activator receptor