title: Factors of primary and secondary sulfonylurea failure in type 2 diabetic subjects.
abstract: BACKGROUND
  The aim of the present study was to investigate the value of clinical characteristics in predicting sulfonylurea (SU) treatment responses.
  
  
  METHODS
  All 747 subjects in the present study were from the Xiaoke Pill Clinical Trial evaluating the safety and efficacy of SU. Subjects had the same initial dose of glibenclamide and drug doses were adjusted every 4 weeks during the 48-week follow-up period. Primary SU failure was defined as a <10% reduction in fasting plasma glucose (FPG) at the end of Week 4 from randomization, whereas secondary SU failure was defined as a consecutive confirmed level of FPG >7 mmol/L.
  
  
  RESULTS
  Kaplan-Meier survival analysis revealed that lower baseline basal disposition index (DIb) and higher FPG predict secondary SU failure. Inversely, higher baseline DIband lower FPG predict primary SU failure. Primary SU failure can predict secondary SU failure. The combination of lower baseline DIbwith primary SU failure is a better predictor of secondary SU failure than lower baseline DIbor primary SU failure alone.
  
  
  CONCLUSIONS
  Patients with good glycemic control and higher β-cell reserve at entry are more likely to experience primary SU failure but are less likely to experience secondary SU failure. By combining baseline DIbwith initial response at the first month of treatment, we can get quick information about the long-term efficacy of SU treatment.
authors.affiliation: Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing, China.
authors.forename: Huaiqing
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Ren
authors.affiliation: Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing, China.
authors.forename: Xueyao
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing, China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing, China.
authors.forename: Yingli
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing, China.
authors.forename: Linong
authors.initials: L
authors.lastname: Ji
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D005215:Fasting / Q000097:blood; D005260:Female; D005905:Glyburide / Q000627:therapeutic use*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data; D011379:Prognosis; D012307:Risk Factors; D017211:Treatment Failure
chemical_list: D001786:Blood Glucose; D005905:Glyburide; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents
keywords: 2型糖尿病; disposition index; sulfonylurea failure; type 2 diabetes; 处置指数; 磺胺类药物治疗失效