title: Gate Control Theory Springs a Leak.
abstract: Sun and colleagues (2017) find that individual Grp+ spinal interneurons can respond to and distinguish between stimuli that provoke itch or pain. The nociceptive response is limited by enkaphalin-expressing interneurons that are connected synaptically to the Grp+ neurons.
authors.affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA.
authors.forename: Paula J S
authors.initials: PJS
authors.lastname: Pereira
authors.affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA. Electronic address: elerner@mgh.harvard.edu.
authors.forename: Ethan A
authors.initials: EA
authors.lastname: Lerner
mesh_terms: D000818:Animals; D005727:Ganglia, Spinal / Q000166:cytology*; D019886:Gastrin-Releasing Peptide / Q000378:metabolism*; D006801:Humans; D007395:Interneurons / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D010146:Pain / Q000503:physiopathology*; D013116:Spinal Cord / Q000503:physiopathology*
chemical_list: D019886:Gastrin-Releasing Peptide