title: Single nucleotide polymorphisms related to cystic fibrosis in chronic rhinositus-a pilot study.
abstract: The clinical association between cystic fibrosis (CF) and chronic rhinosinusitis (CRS) is well known. Studies have identified several non-CF transmembrane conductance regulator single nucleotide polymorphisms (SNPs) associated with disease severity in CF patients. We hypothesized that prevalence of these SNPs would be different between CRS patients and age/gender-matched non-CRS controls.
  
  
  
  This is a targeted SNP study of 1231 CRS patients identified through a large university hospital database who were compared with 8796 age- and gender-matched controls without a history of rhinitis, sinusitis, allergies, or asthma. Prevalence of 5 relevant SNPs was compared between groups, with p < 0.05 considered significant. Stratification by race and gender was performed among groups when statistically appropriate.
  
  
  
  CRS patients exhibited a statistically significant (p = 0.036) lower prevalence of rs12883884 (associated with an ion transporter) compared with controls. This association was lost when patients were stratified by race. CRS patients manifested a greater prevalence of rs1403543 (chromosome 23) in both Caucasian and African American subgroups (p = 0.036 and p = 0.026, respectively). Statistical significance disappeared among Caucasians when stratified by gender, but persisted among African American women (p = 0.047). rs12188164 and rs12793173 were both more prevalent in African Americans with CRS than controls (p = 0.042 and p = 0.020, respectively). A trend was also observed for decreased prevalence of rs12883884 in CRS patients compared with controls in the African American subgroup (p = 0.086).
  
  
  
  The identified SNPs were differentially prevalent in CRS compared with control groups, with some variability as a function of race and gender. Further research is required to confirm these findings and elucidate clinical significance.
authors.affiliation: Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, TN.
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Hull
authors.affiliation: Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO.
authors.forename: Pawina
authors.initials: P
authors.lastname: Jiramongkolchai
authors.affiliation: Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, TN.
authors.forename: Justin H
authors.initials: JH
authors.lastname: Turner
authors.affiliation: VANGARD Core Facility of Vanderbilt University School of Medicine, Nashville, TN.
authors.forename: Lana
authors.initials: L
authors.lastname: Olson
authors.affiliation: Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, TN.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Chandra
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D012220:Rhinitis / Q000235:genetics*; D012852:Sinusitis / Q000235:genetics*
keywords: biomarker; chronic disease; chronic rhinosinusitis; paranasal sinus diseases; sinusitis