title: Effects of meso-2,3-dimercaptosuccinic acid, potassium iodide and chlorophyll on lead accumulation in male mice.
abstract: OBJECTIVE
  Lead (Pb) pollution is a serious public health problem all over the world, it especially plays severe damage role in children's health. Apart from reducing lead-induced damages, the decrease of lead accumulation is also critical. This study has been the first attempt to investigate effects of meso-2,3-dimercaptosuccinic acid (DMSA), potassium iodide (KI) and chlorophyll (Chl) on lead accumulation in male mice.
  
  
  METHODS
  Eighty healthy Kunming male mice were selected and divided randomly into 8 groups. They were treated with lead acetate (PbAc) intraperitoneally, individually and in combination with the DMSA, KI or Chl once daily for 5 days. Meanwhile, the control group was treated with normal saline during the whole exposure period. On 30th day, mice were sacrificed and lead concentrations were detected in the whole blood, livers, kidneys, and testicles of mice by means of the graphite furnace atomic absorption spectrometry.
  
  
  RESULTS
  In comparison with the control group, lead concentrations increased in mice treated with the PbAc and DMSA, KI and Chl diminished lead accumulation in the whole blood, livers, and kidneys. Chl had specifically the same effects on lead concentrations in the testicles of male mice.
  
  
  CONCLUSIONS
  Potassium iodide and Chl, as food additives, had the same effects as the DMSA to reduce lead accumulation in male mice effectively. Our results provided experimental evidence in vivo for the preventive measures of lead poisoning. Int J Occup Med Environ Health 2017;30(1):87-93.
authors.affiliation: Hunan Normal University, Changsha, China (College of Medicine, Department of Preventive Medicine). lilac0408@sina.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Hunan Normal University, Changsha, China (College of Medicine, Department of Preventive Medicine). guifengzhou66@sina.com.
authors.forename: Guifeng
authors.initials: G
authors.lastname: Zhou
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use*; D002734:Chlorophyll / Q000627:therapeutic use*; D005503:Food Additives; D007668:Kidney / Q000737:chemistry; D007854:Lead / Q000032:analysis / Q000097:blood; D007855:Lead Poisoning / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D008099:Liver / Q000737:chemistry; D008297:Male; D051379:Mice; D011193:Potassium Iodide / Q000627:therapeutic use*; D004113:Succimer / Q000627:therapeutic use*; D013737:Testis / Q000737:chemistry
chemical_list: D002614:Chelating Agents; D005503:Food Additives; D002734:Chlorophyll; D011193:Potassium Iodide; D007854:Lead; D004113:Succimer
keywords: 3-dimercaptosuccinic acid; chlorophyll; food additives; lead accumulation; meso-2; mice; potassium iodide