title: Linear relationship found by magnetic resonance imaging between cerebrospinal fluid volume and body weight in dogs.
abstract: Despite numerous studies on cerebrospinal fluid (CSF) and its importance during hydrocephalus or myelography, no reliable values exist about its overall volume in dogs. In this study, our aim was to measure the intracranial (IC) volume of CSF in dogs and assess its possible relationship with body size and the symmetry of the lateral ventricles. We ran a 3D magnetic resonance imaging (MRI) sequence on the central nervous system of 12 healthy, male mongrel dogs between 3-5 years of age and 7.5-35.0 kg body weight. A validated semiautomatic segmentation protocol was implemented to segment the CSF and measure its volume. Values for the volume of the ventricular compartment were between 0.97 and 2.94 ml, with 62.1 ± 11.7% in the lateral ventricles, 17.6 ± 4.9% in the third ventricle, 4.9 ± 1.6% in the aqueductus mesencephali and 15.5 ± 6.6% in the fourth ventricle. In 11 cases a significant asymmetry was found between the lateral ventricles. The results suggest that it may be normal for a dog to have one of the lateral ventricles 1.5 times larger than the other. The correlation between body weight and CSF volume was linear, indicating that the current dosage protocols for myelography, based on a hypothetical proportional relationship with body weight, may have to be revised.
authors.affiliation: Department of Anatomy and Histology, University of Veterinary Medicine , István u. 2, H-1078 Budapest , Hungary.
authors.forename: László Z
authors.initials: LZ
authors.lastname: Reinitz
authors.affiliation: Institute of Diagnostic Imaging and Radiation Oncology, Kaposvár University , Kaposvár , Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Bajzik
authors.affiliation: Institute of Diagnostic Imaging and Radiation Oncology, Kaposvár University , Kaposvár , Hungary.
authors.forename: Rita
authors.initials: R
authors.lastname: Garamvölgyi
authors.affiliation: Department of Anatomy and Histology, University of Veterinary Medicine , István u. 2, H-1078 Budapest , Hungary.
authors.forename: Bianka
authors.initials: B
authors.lastname: Benedek
authors.affiliation: Institute of Diagnostic Imaging and Radiation Oncology, Kaposvár University , Kaposvár , Hungary.
authors.forename: Örs
authors.initials: Ö
authors.lastname: Petneházy
authors.affiliation: School of Computing, Queen's University , Kingston , Canada.
authors.forename: András
authors.initials: A
authors.lastname: Lassó
authors.affiliation: Department of Biomathematics and Informatics, University of Veterinary Medicine , Budapest , Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Abonyi-Tóth
authors.affiliation: Institute of Diagnostic Imaging and Radiation Oncology, Kaposvár University , Kaposvár , Hungary.
authors.forename: Borbála
authors.initials: B
authors.lastname: Lőrincz
authors.affiliation: Department of Anatomy and Histology, University of Veterinary Medicine , István u. 2, H-1078 Budapest , Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Sótonyi
mesh_terms: D000818:Animals; D001835:Body Weight / Q000502:physiology*; D002552:Cerebral Ventricles / Q000033:anatomy & histology; D014695:Cerebral Ventriculography; D003287:Contrast Media; D004285:Dogs / Q000134:cerebrospinal fluid* / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D003287:Contrast Media
keywords: Cerebrospinal fluid; MRI; dog; hydrocephalus; volume