title: Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?
abstract: Role of lithium chloride and paraldehyde in acute changes after lithium-pilocarpine status epilepticus (SE) induced at postnatal day 12 was studied in 15-day-old rats. In addition to SE group four other groups were formed: naïve animals without any injection, lithium chloride group, paraldehyde group and lithium-paraldehyde group. Cortical epileptic afterdischarges (CxADs) induced by increasing intensities of stimulation current were used as a measure of excitability. SE animals did not exhibit any change in duration of CxADs with increasing stimulation intensity in contrast to naïve control with a progressive prolongation of CxAD. LiCl group was similar to SE rats whereas paraldehyde and lithium-paraldehyde groups exhibited some progress in duration of ADs. Lithium chloride participates in short-term changes of CxADs after SE. Paraldehyde and combination of lithium and paraldehyde are similar to naïve controls.
authors.affiliation: Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
authors.forename: Grygoriy
authors.initials: G
authors.lastname: Tsenov
authors.affiliation: Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Kubová
authors.affiliation: Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic. Electronic address: maresp@biomed.cas.cz.
authors.forename: Pavel
authors.initials: P
authors.lastname: Mareš
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects; D003292:Convulsants / Q000494:pharmacology*; D004195:Disease Models, Animal; D018021:Lithium Chloride / Q000494:pharmacology*; D008297:Male; D010242:Paraldehyde / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000139:chemically induced*
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D010862:Pilocarpine; D018021:Lithium Chloride; D010242:Paraldehyde
keywords: Cortical epileptic afterdischarges; Immature rats; Lithium chloride; Paraldehyde; Pilocarpine; Status epilepticus