title: Early-stage Favourable Anal Cancer: A Retrospective Analysis of Clinical Outcomes of a Moderately Low Dose Elective Nodal Intensity-modulated Radiotherapy Schedule.
abstract: In this retrospective study we evaluated the long-term results of 35 early-stage favourable T1-2 N0 M0 anal cancer patients treated with intensity-modulated radiotherapy techniques combining low dose prophylactic inguinal-pelvic irradiation with dose-escalated boost. Optimal locoregional control and good tolerance makes this treatment a valuable alternative to brachytherapy boost and involved-field radiotherapy plans.
authors.affiliation: Radiation Oncology, Geneva University Hospital - HUG, Geneva, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Lestrade
authors.affiliation: Radiation Oncology, Geneva University Hospital - HUG, Geneva, Switzerland. Electronic address: Thomas.Zilli@hcuge.ch.
authors.forename: T
authors.initials: T
authors.lastname: Zilli
authors.affiliation: Radiation Oncology, Geneva University Hospital - HUG, Geneva, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Kountouri
authors.affiliation: Radiation Oncology, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Jumeau
authors.affiliation: Radiation Oncology, Riviera Hospital, Vevey, Switzerland.
authors.forename: O
authors.initials: O
authors.lastname: Matzinger
authors.affiliation: Radiation Oncology, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Bourhis
authors.affiliation: Radiation Oncology, Geneva University Hospital - HUG, Geneva, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Miralbell
authors.affiliation: Radiation Oncology, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Ozsahin
authors.affiliation: Radiation Oncology, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: De Bari
mesh_terms: D000328:Adult; D000368:Aged; D001005:Anus Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Anal cancer; IMRT; early-stage; local control; radiotherapy; toxicity