title: Mechano-sensitive regulation of gene expression during the embryonic development.
abstract: Cell movements during embryogenesis produce mechanical tensions that shape the embryo and can also regulate gene expression, thereby affecting cell differentiation. Increasing evidence indicates that mechanosensitive regulation of gene expression plays important roles during embryogenesis by coupling the processes of morphogenesis and differentiation. However, the molecular mechanisms of this phenomenon remain poorly understood. This review focuses on the molecular mechanisms that "translate" mechanical stimuli into gene expression.
authors.affiliation: Laboratory of Molecular Bases of Embryogenesis, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: Fedor M
authors.identifier: 0000-0001-7223-6598
authors.initials: FM
authors.lastname: Eroshkin
authors.affiliation: Laboratory of Molecular Bases of Embryogenesis, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: Andrey G
authors.initials: AG
authors.lastname: Zaraisky
mesh_terms: D000818:Animals; D047108:Embryonic Development; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D040542:Mechanotransduction, Cellular; D015533:Transcriptional Activation
keywords: convergent extension; embryogenesis; gene expression; mechanical stress; mechanotransduction