title: Nanocapsules engineered from polyhedral ZIF-8 templates for bone-targeted hydrophobic drug delivery.
abstract: A novel bone-targeted delivery systems based on nanocapsules was developed utilizing a Zeolitic Imidazolate Framework (ZIF-8) as a template and catechol-modified gelatin as wall material. A targeting ligand was facilely conjugated on the surface of nanocapsules. Simvastatin was encapsulated within the nanocapsules with a loading of 37.9%. Hydroxyapatite binding and in vivo biodistribution of the drug-loaded nanocapsules were investigated.
authors.affiliation: Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China. sun-hf@139.com.
authors.forename: Xiaoli
authors.identifier: http://orcid.org/0000-0003-3136-9807
authors.initials: X
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China. sun-hf@139.com.
authors.forename: Dandan
authors.initials: D
authors.lastname: Miao
authors.affiliation: Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China. sun-hf@139.com.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Liang
authors.affiliation: Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China. sun-hf@139.com.
authors.forename: Jiayi
authors.initials: J
authors.lastname: Liang
authors.affiliation: Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China. sun-hf@139.com.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China. sun-hf@139.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China. sun-hf@139.com and The Key Laboratory of Bioactive Materials of Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, Tianjin, China.
authors.forename: Deling
authors.identifier: http://orcid.org/0000-0002-2961-9267
authors.initials: D
authors.lastname: Kong
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China. sun-hf@139.com.
authors.forename: Hongfan
authors.identifier: http://orcid.org/0000-0003-0686-534X
authors.initials: H
authors.lastname: Sun
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002460:Cell Line; D016503:Drug Delivery Systems / Q000379:methods; D005780:Gelatin / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007093:Imidazoles / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D051381:Rats; D019821:Simvastatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014018:Tissue Distribution; D017641:Zeolites / Q000737:chemistry*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007093:Imidazoles; D053769:Nanocapsules; D017641:Zeolites; D005780:Gelatin; D019821:Simvastatin