title: Streptenols F-I Isolated from the Marine-Derived Streptomyces misionensis BAT-10-03-023.
abstract: A marine-derived bacterium, Streptomyces misionensis BAT-10-03-123, has produced four new streptenol derivatives, F, G, H, and I (1-4), as well as the known streptenols A and C (5 and 6). Their planar structures were elucidated by detailed analysis of spectroscopic data. The absolute configurations of the new streptenol compounds were determined by chemical and spectroscopic methods, including Mosher's ester method. All of the compounds were tested for cytotoxicity against four selected cancer cell lines.
authors.affiliation: Research & Development Department, PharmaMar S. A. , Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770, Colmenar Viejo, Madrid, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Tarazona
authors.affiliation: Research & Development Department, PharmaMar S. A. , Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770, Colmenar Viejo, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Schleissner
authors.affiliation: Research & Development Department, PharmaMar S. A. , Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770, Colmenar Viejo, Madrid, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Rodríguez
authors.affiliation: Research & Development Department, PharmaMar S. A. , Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770, Colmenar Viejo, Madrid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Pérez
authors.affiliation: Research & Development Department, PharmaMar S. A. , Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770, Colmenar Viejo, Madrid, Spain.
authors.forename: Librada Ma
authors.identifier: 0000-0002-1273-4138
authors.initials: LM
authors.lastname: Cañedo
authors.affiliation: Research & Development Department, PharmaMar S. A. , Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770, Colmenar Viejo, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuevas
mesh_terms: D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000970:Antineoplastic Agents