title: Mapping of the continuous epitopes displayed on the Clostridium perfringens type D epsilon-toxin.
abstract: The epsilon toxin, produced by Clostridium perfringens, is responsible for enterotoxemia in ruminants and is a potential bioterrorism agent. In the present study, 15 regions of the toxin were recognized by antibodies present in the serum, with different immunodominance scales, and may be antigen determinants that can be used to formulate subunit vaccines.
authors.affiliation: Universidade Federal de Minas Gerais (UFMG), Escola de Veterinária, Belo Horizonte, MG, Brazil. Electronic address: guilhermeguerra.vet@gmail.com.
authors.forename: Guilherme Guerra
authors.initials: GG
authors.lastname: Alves
authors.affiliation: Universidade Federal de Minas Gerais (UFMG), Instituto de Ciências Biológicas, Belo Horizonte, MG, Brazil; Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
authors.forename: Ricardo Andrez
authors.initials: RA
authors.lastname: Machado-de-Ávila
authors.affiliation: Universidade Federal de Minas Gerais (UFMG), Instituto de Ciências Biológicas, Belo Horizonte, MG, Brazil.
authors.forename: Carlos Delfin
authors.initials: CD
authors.lastname: Chávez-Olórtegui
authors.affiliation: Universidade Federal de Minas Gerais (UFMG), Escola de Veterinária, Belo Horizonte, MG, Brazil.
authors.forename: Rodrigo Otávio Silveira
authors.initials: ROS
authors.lastname: Silva
authors.affiliation: Universidade Federal de Minas Gerais (UFMG), Escola de Veterinária, Belo Horizonte, MG, Brazil.
authors.forename: Francisco Carlos Faria
authors.initials: FCF
authors.lastname: Lobato
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000737:chemistry* / Q000235:genetics / Q000276:immunology; D003016:Clostridium perfringens / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D004767:Enterotoxemia / Q000382:microbiology; D018604:Epitope Mapping; D000939:Epitopes / Q000737:chemistry* / Q000235:genetics / Q000276:immunology
chemical_list: D001427:Bacterial Toxins; D000939:Epitopes
keywords: Enterotoxemia; Epitope; Epsilon; Mapping; Toxin