title: Risk of alcohol use relapse after liver transplantation for alcoholic liver disease.
abstract: OBJECTIVE
  To investigate factors, including psychosocial factors, associated with alcoholic use relapse after liver transplantation (LT) for alcoholic liver disease (ALD).
  
  
  METHODS
  The clinical records of 102 patients with ALD who were referred to Nagoya University Hospital for LT between May 2003 and March 2015 were retrospectively evaluated. History of alcohol intake was obtained from their clinical records and scored according to the High-Risk Alcoholism Relapse scale, which includes duration of heavy drinking, types and amount of alcohol usually consumed, and previous inpatient treatment history for alcoholism. All patients were assessed for eligibility for LT according to comprehensive criteria, including Child-Pugh score, Model for End-Stage Liver Disease score, and psychosocial criteria.
  
  
  RESULTS
  Of the 102 patients with ALD referred for LT, seven (6.9%) underwent LT. One (14.3%) of these seven patients returned to heavy drinking, but that patient was able to successfully quit drinking following an immediate intervention, consisting of psychotherapeutic education and supportive psychotherapy, by a psychiatrist. A comparison between the transplantation/registration (T/R) group, consisting of the seven patients who underwent LT and 10 patients listed for deceased donor LT, and 50 patients who did not undergo LT and were not listed for deceased donor LT (non-T/R group), showed statistically significant differences in duration of abstinence period (P< 0.01), duration of heavy drinking (P< 0.05), adherence to medical treatment (P< 0.01), and declaration of abstinence (P< 0.05).
  
  
  CONCLUSIONS
  Patients with ALD referred for LT require comprehensive evaluation, including evaluation of psychosocial criteria, to prevent alcoholic recidivism.
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Onishi
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kimura
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Tomohide
authors.initials: T
authors.lastname: Hori
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kishi
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Hideya
authors.initials: H
authors.lastname: Kamei
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Kurata
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Chisato
authors.initials: C
authors.lastname: Tsuboi
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Yamaguchi
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Mayu
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Saki
authors.initials: S
authors.lastname: Sunada
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Hirano
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Fujishiro
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Okada
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ishigami
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Hidemi
authors.initials: H
authors.lastname: Goto
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.affiliation: Yasuharu Onishi, Tomohide Hori, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura, Department of Transplantation Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ogura
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000517:prevention & control / Q000523:psychology / Q000628:therapy; D005260:Female; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000523:psychology / Q000601:surgery*; D016031:Liver Transplantation / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011584:Psychology; D011613:Psychotherapy; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013695:Temperance / Q000523:psychology
keywords: Alcohol use relapse; Alcoholic liver disease; Liaison psychiatry; Liver transplantation; Psychosocial evaluation criteria; Risk assessment