title: High-Density Single-Layer Coating of Gold Nanoparticles onto Multiple Substrates by Using an Intrinsically Disordered Protein of α-Synuclein for Nanoapplications.
abstract: Functional graffiti of nanoparticles onto target surface is an important issue in the development of nanodevices. A general strategy has been introduced here to decorate chemically diverse substrates with gold nanoparticles (AuNPs) in the form of a close-packed single layer by using an omni-adhesive protein of α-synuclein (αS) as conjugated with the particles. Since the adsorption was highly sensitive to pH, the amino acid sequence of αS exposed from the conjugates and its conformationally disordered state capable of exhibiting structural plasticity are considered to be responsible for the single-layer coating over diverse surfaces. Merited by the simple solution-based adsorption procedure, the particles have been imprinted to various geometric shapes in 2-D and physically inaccessible surfaces of 3-D objects. The αS-encapsulated AuNPs to form a high-density single-layer coat has been employed in the development of nonvolatile memory, fule-cell, solar-cell, and cell-culture platform, where the outlying αS has played versatile roles such as a dielectric layer for charge retention, a sacrificial layer to expose AuNPs for chemical catalysis, a reaction center for silicification, and biointerface for cell attachment, respectively. Multiple utilizations of the αS-based hybrid NPs, therefore, could offer great versatility to fabricate a variety of NP-integrated advanced materials which would serve as an indispensable component for widespread applications of high-performance nanodevices.
authors.forename: Ghibom
authors.initials: G
authors.lastname: Bhak
authors.forename: Junghee
authors.initials: J
authors.lastname: Lee
authors.affiliation: School of Materials Science and Engineering, Gwangju Institute of Science and Technology , Gwangju 500-712, Korea.
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Kim
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science , Seoul 151-747, Korea.
authors.forename: Dong Young
authors.initials: DY
authors.lastname: Chung
authors.forename: Jin Hyoun
authors.initials: JH
authors.lastname: Kang
authors.forename: Soojung
authors.initials: S
authors.lastname: Oh
authors.forename: Jungsup
authors.initials: J
authors.lastname: Lee
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science , Seoul 151-747, Korea.
authors.forename: Jin Soo
authors.initials: JS
authors.lastname: Kang
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science , Seoul 151-747, Korea.
authors.forename: Ji Mun
authors.initials: JM
authors.lastname: Yoo
authors.forename: Jee Eun
authors.initials: JE
authors.lastname: Yang
authors.forename: Kun Yil
authors.initials: KY
authors.lastname: Rhoo
authors.forename: Sunghak
authors.initials: S
authors.lastname: Park
authors.forename: Somin
authors.initials: S
authors.lastname: Lee
authors.forename: Ki Tae
authors.identifier: http://orcid.org/0000-0001-6353-8877
authors.initials: KT
authors.lastname: Nam
authors.forename: Noo Li
authors.initials: NL
authors.lastname: Jeon
authors.forename: Jyongsik
authors.identifier: http://orcid.org/0000-0002-0415-802X
authors.initials: J
authors.lastname: Jang
authors.forename: Byung Hee
authors.initials: BH
authors.lastname: Hong
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science , Seoul 151-747, Korea.
authors.forename: Yung-Eun
authors.initials: YE
authors.lastname: Sung
authors.affiliation: School of Materials Science and Engineering, Gwangju Institute of Science and Technology , Gwangju 500-712, Korea.
authors.forename: Myung-Han
authors.initials: MH
authors.lastname: Yoon
authors.forename: Seung R
authors.identifier: http://orcid.org/0000-0002-0928-6098
authors.initials: SR
authors.lastname: Paik
mesh_terms: D000327:Adsorption; D006046:Gold; D064267:Intrinsically Disordered Proteins; D053768:Metal Nanoparticles; D051844:alpha-Synuclein
chemical_list: D064267:Intrinsically Disordered Proteins; D051844:alpha-Synuclein; D006046:Gold
keywords: adsorption; gold nanoparticles; intrinsically disordered protein; nanoapplications; nanoparticle single layer; omni-adhesive protein; α-synuclein