title: In vivo study of osteogenerating properties of calcium-phosphate coating on titanium alloy Ti-6Al-4V.
abstract: The method of formation of bioactive calcium-phosphate coating on medical titanium alloy Ti-6Al-4V (3.5-5.3% V; 5.3-6.8% Al; balance -Ti) by plasma electrolytic oxidation (PEO) has been developed. Evaluation of osteogenerating properties of the coating at fractures of the shaft of the femur on Wistar line laboratory rats has been performed. It has been established that the calcium-phosphate PEO coating accelerates osteogenesis and promotes the formation of a pronounced periosteal callus in the fracture area. The presence of calcium phosphates in the PEO coating surface layer significantly accelerates the growth of bone tissue on the titanium surface.
authors.affiliation: Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159, Prosp. 100-letiya Vladivostoka, Vladivostok 690022, Russia.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Gnedenkov
authors.affiliation: Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159, Prosp. 100-letiya Vladivostoka, Vladivostok 690022, Russia.
authors.forename: Sergey L
authors.initials: SL
authors.lastname: Sinebryukhov
authors.affiliation: Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159, Prosp. 100-letiya Vladivostoka, Vladivostok 690022, Russia.
authors.forename: Artyom V
authors.initials: AV
authors.lastname: Puz
authors.affiliation: Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159, Prosp. 100-letiya Vladivostoka, Vladivostok 690022, Russia.
authors.forename: Vladimir S
authors.initials: VS
authors.lastname: Egorkin
authors.affiliation: Pacific State Medical University, 2, Prosp. Ostryakova, Vladivostok, Russia.
authors.forename: Roman E
authors.initials: RE
authors.lastname: Kostiv
mesh_terms: D000085:Acetates / Q000097:blood; D000497:Alloys; D000818:Animals; D017610:Calcium Compounds / Q000097:blood; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology; D005264:Femoral Fractures / Q000188:drug therapy; D005994:Glycerophosphates / Q000097:blood; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000085:Acetates; D000497:Alloys; D017610:Calcium Compounds; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D005994:Glycerophosphates; C031462:titanium alloy (TiAl6V4); D017886:Durapatite; C020243:calcium phosphate; D014025:Titanium; C120662:calcium acetate
keywords: Calcium-phosphate coatings; implant; osteogenesis; plasma electrolytic oxidation; titanium alloy Ti–6Al–4V