title: Efficient Computation of Functional Brain Networks: toward Real-Time Functional Connectivity.
abstract: Functional Connectivity has demonstrated to be a key concept for unraveling how the brain balances functional segregation and integration properties while processing information. This work presents a set of open-source tools that significantly increase computational efficiency of some well-known connectivity indices and Graph-Theory measures. PLV, PLI, ImC, and wPLI as Phase Synchronization measures, Mutual Information as an information theory based measure, and Generalized Synchronization indices are computed much more efficiently than prior open-source available implementations. Furthermore, network theory related measures like Strength, Shortest Path Length, Clustering Coefficient, and Betweenness Centrality are also implemented showing computational times up to thousands of times faster than most well-known implementations. Altogether, this work significantly expands what can be computed in feasible times, even enabling whole-head real-time network analysis of brain function.
authors.affiliation: Department of Industrial Engineering, Laboratory of Electrical Engineering and Bioengineering, Universidad de La LagunaTenerife, Spain; Laboratory of Computational and Cognitive Neuroscience, Centre of Biomedical Technology, UPMMadrid, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: García-Prieto
authors.affiliation: Laboratory of Computational and Cognitive Neuroscience, Centre of Biomedical Technology, UPMMadrid, Spain; Department of Statistics and Operative Research, Faculty of Medicine, Universidad Complutense de MadridMadrid, Spain.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Bajo
authors.affiliation: Department of Industrial Engineering, Laboratory of Electrical Engineering and Bioengineering, Universidad de La LagunaTenerife, Spain; Laboratory of Computational and Cognitive Neuroscience, Centre of Biomedical Technology, UPMMadrid, Spain; Institute of Biomedical Technology (CIBICAN), Universidad de La LagunaTenerife, Spain.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Pereda
keywords: Functional Connectivity; brain-computer interface (BCI); complex networks; electroencephalogram (EEG); graph-theory; magnetoencephalography (MEG); neuro-feedback