title: Uncovering the roles of long non-coding RNAs in cancer stem cells.
abstract: Cancer has been a major public health problem that has threatened human life worldwide throughout history. The main causes that contribute to the poor prognosis of cancer are metastasis and recurrence. Cancer stem cells are a group of tumor cells that possess self-renewal and differentiation ability, which is a vital cause of cancer metastasis and recurrence. Long non-coding RNAs refer to a class of RNAs that are longer than 200 nt and have no potential to code proteins, some of which can be specifically expressed in different tissues and different tumors. Long non-coding RNAs have great biological significance in the occurrence and progression of cancers. However, how long non-coding RNAs interact with cancer stem cells and then affect cancer metastasis and recurrence is not yet clear. Therefore, this review aims to summarize recent studies that focus on how long non-coding RNAs impact tumor occurrence and progression by affecting cancer stem cell self-renewal and differentiation in liver cancer, prostate cancer, breast cancer, and glioma.
authors.affiliation: Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.
authors.forename: Xiaoxing
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.
authors.forename: Ruijing
authors.initials: R
authors.lastname: Xiao
authors.affiliation: Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Pan
authors.affiliation: Hubei University of Technology Engineering and Technology College, Wuhan, 430000, China.
authors.forename: Xiangyong
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Yuan
authors.affiliation: Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.
authors.forename: Zhenbo
authors.initials: Z
authors.lastname: Tu
authors.affiliation: Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.
authors.forename: Yufan
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yin
authors.affiliation: Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Shao
authors.affiliation: Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xiong
authors.affiliation: Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China. qpzhang@whu.edu.cn.
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology; D002454:Cell Differentiation; D000066673:Cell Self Renewal; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D008297:Male; D009362:Neoplasm Metastasis; D014411:Neoplastic Stem Cells / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology; D062085:RNA, Long Noncoding / Q000494:pharmacology / Q000502:physiology*; D012008:Recurrence
chemical_list: D062085:RNA, Long Noncoding
keywords: Cancer stem cells; Long non-coding RNAs; Malignant transformation; Self-renewal; Tumor metastasis; Tumor recurrence