title: Diastereoselective Synthesis of Spirocyclopropanes under Mild Conditions via Formal [2 + 1] Cycloadditions Using 2,3-Dioxo-4-benzylidene-pyrrolidines.
abstract: A highly diastereoselective cyclopropanation of cyclic enones with sulfur ylides was developed under catalyst-free conditions, producing multifunctional spirocyclopropanes in generally excellent yields (up to 99% yield and >99:1 d.r.). The asymmetric version of this method was realized by using an easily available chiral sulfur ylide, affording products with moderate to good stereoselectivity.
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China. lee90918@outlook.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China. lqz_0519@163.com.
authors.forename: Qing-Zhu
authors.initials: QZ
authors.lastname: Li
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China. lilililylily@outlook.com.
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China. Lianghong@mail.cdu.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China. Kaichuanyang@163.com.
authors.forename: Kai-Chuan
authors.initials: KC
authors.lastname: Yang
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China. lnavy@126.com.
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Leng
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China. lucindalau1225@sina.com.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China. shenxudong@cdu.edu.cn.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Shen
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China. gouxj@163.com.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Gou
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China. lijunlong709@hotmail.com.
authors.forename: Jun-Long
authors.initials: JL
authors.lastname: Li
mesh_terms: D001597:Benzylidene Compounds / Q000737:chemistry*; D002384:Catalysis; D061565:Cycloaddition Reaction; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry
chemical_list: D001597:Benzylidene Compounds; D003521:Cyclopropanes; D011759:Pyrrolidines; D013141:Spiro Compounds; D013455:Sulfur
keywords: catalyst free; diastereoselective synthesis; spirocyclopropanes; sulfur ylide