title: Dietary inflammatory index and odds of colorectal cancer in a case-control study from Jordan.
abstract: Dietary components that promote inflammation of the colon have been suggested to be risk factors in the development of colorectal cancer (CRC). The possible link between inflammatory potential of diet and CRC has been investigated in several developed or Western countries. Despite the fact that dietary choices in the Middle East differ markedly from those in the West, results have not been reported from any study conducted in a Middle-Eastern population. We examined the association between dietary inflammatory index (DII) scores and CRC in a case-control study conducted in Jordan. This study included 153 histopathologically confirmed CRC cases and 202 disease-free control subjects' frequency matched on age, sex, and occupation. Data were collected between January 2010 and December 2012, using interviewer-administered questionnaires. DII scores were computed from dietary data reported using a food frequency questionnaire. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for age, sex, education, physical activity, body mass index, smoking, and family history of CRC. Subjects with higher DII scores were at increased odds of CRC, with the DII being used both as a continuous variable (ORcontinuous= 1.45, 95% CI: 1.13-1.85; 1-unit increase corresponding to ≈20% of its range in the current study) and as a categorical variable (ORtertile 3 vs tertile 1= 2.13, 95%CI: 1.23-3.72). Our results, based on a Jordanian population, add to the growing literature indicating that a pro-inflammatory diet is associated with increased odds of CRC.
authors.affiliation: a Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USA.|b Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.|c Connecting Health Innovations LLC, Columbia, SC 29201, USA.
authors.forename: Nitin
authors.initials: N
authors.lastname: Shivappa
authors.affiliation: a Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USA.|b Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.|c Connecting Health Innovations LLC, Columbia, SC 29201, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Hébert
authors.affiliation: b Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Steck
authors.affiliation: d South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.
authors.forename: Lorne J
authors.initials: LJ
authors.lastname: Hofseth
authors.affiliation: e Gastroenterology Division, King Hussein Cancer Center, P.O. Box 1269, Amman 11941, Jordan.
authors.forename: Ihab
authors.initials: I
authors.lastname: Shehadah
authors.affiliation: f Faculty of Medicine, Hashemite University, P.O. Box 330127, Zarqa 13133, Jordan.
authors.forename: Kamal E
authors.initials: KE
authors.lastname: Bani-Hani
authors.affiliation: g Department of Surgery, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.
authors.forename: Tareq
authors.initials: T
authors.lastname: Al-Jaberi
authors.affiliation: h Division of Gastroenterology, Prince Hamza Hospital, P.O. Box 86, Amman 11118, Jordan.
authors.forename: Majed
authors.initials: M
authors.lastname: Al-Nusairr
authors.affiliation: i Cancer Prevention and Control Program, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Dennis
authors.initials: D
authors.lastname: Heath
authors.affiliation: j Department of Nutrition and Food Technology, The University of Jordan, Faculty of Agriculture, P.O. Box 2920, Amman 11941, Jordan.
authors.forename: Reema
authors.initials: R
authors.lastname: Tayyem
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D004032:Diet; D015444:Exercise; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology*; D007597:Jordan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D012307:Risk Factors; D012959:Socioeconomic Factors; D055815:Young Adult
keywords: alimentation; cytokines; diet; dietary inflammatory index; epidemiology; indice d’inflammation alimentaire; inflammation; nutrition; régime alimentaire; épidémiologie