title: Quorum Sensing Inhibitors from the Sea Discovered Using Bacterial N-acyl-homoserine Lactone-Based Biosensors.
abstract: Marine natural products with antibiotic activity have been a rich source of drug discovery; however, the emergence of antibiotic-resistant bacterial strains has turned attention towards the discovery of alternative innovative strategies to combat pathogens. In many pathogenic bacteria, the expression of virulence factors is under the regulation of quorum sensing (QS). QS inhibitors (QSIs) present a promising alternative or potential synergistic treatment since they disrupt the signaling pathway used for intra- and interspecies coordination of expression of virulence factors. This review covers the set of molecules showing QSI activity that were isolated from marine organisms, including plants (algae), animals (sponges, cnidarians, and bryozoans), and microorganisms (bacteria, fungi, and cyanobacteria). The compounds found and the methods used for their isolation are the emphasis of this review.
authors.affiliation: Department of Marine Biology, Leon H. Charney School of Marine Sciences, University of Haifa, Mt. Carmel, 31905 Haifa, Israel. sauravverma17@gmail.com.
authors.forename: Kumar
authors.initials: K
authors.lastname: Saurav
authors.affiliation: The NeaNat Group, Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy. costanti@unina.it.
authors.forename: Valeria
authors.initials: V
authors.lastname: Costantino
authors.affiliation: Bacteriology Group, International Centre for Genetic Engineering & Biotechnology, Padriciano 99, 34149 Trieste, Italy. venturi@icgeb.org.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Venturi
authors.affiliation: Department of Marine Biology, Leon H. Charney School of Marine Sciences, University of Haifa, Mt. Carmel, 31905 Haifa, Israel. lsteindler@univ.haifa.ac.il.
authors.forename: Laura
authors.initials: L
authors.lastname: Steindler
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000494:pharmacology; D054742:Acyl-Butyrolactones / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects; D001688:Biological Products / Q000494:pharmacology; D015374:Biosensing Techniques / Q000379:methods; D005658:Fungi / Q000187:drug effects; D006801:Humans; D053038:Quorum Sensing / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D054742:Acyl-Butyrolactones; D000900:Anti-Bacterial Agents; D001688:Biological Products; C088386:homoserine lactone; D015107:4-Butyrolactone
keywords: N-acyl homoserine lactones; antimicrobial resistance; marine natural products; quorum quenching; quorum-sensing inhibitors