title: Frequency of papillary tubal hyperplasia (PTH), salpingoliths and transition from adenoma to borderline ovarian tumors (BOT): A systematic analysis of 74 BOT with different histologic types.
abstract: Borderline ovarian tumors (BOT) arise from cystadenomas and represent a transition step within the development of low-grade ovarian carcinomas (Type I tumors). That pathway mirrors the adenoma-to-carcinoma sequence known for colorectal cancer. It has been suggested that papillary tubal hyperplasia (PTH) and salpingoliths may be associated with the development of BOT. To evaluate the frequency of the presence of benign cystadenoma and its transition to BOT in a given patient as well as the presence of PTH and salpingoliths we re-valuated in 74 consecutive cases of BOT with different histologic types. The majority of cases represented serous-BOT (60.8%), followed by mucinous BOT (25.7%), other histologic types were rare. 86.5% showed an adenoma-BOT sequence, which was seen in all mucinous BOT but was missed in 15.6% of serous BOT. Two cases had salpingoliths without associated PTH. PTH was seen in four out of the 74 (5.4%) BOT and occurred only in cases with serous histology. The vast majority of BOT represent a transition from benign cystadenoma to BOT in cases with mucinous and serous histology. Salpingoliths are rarely seen in association with BOT and occurred exclusively in BOT with serous histology. PTH may represent a distinct lesion but is rarely seen in association with BOT, especially in those with non-serous histology. Further studies are needed to evaluate the frequency and pathogenetic association of PTH with BOT.
authors.affiliation: Institute of Pathology, Division of Breast, Gynecologic & Perinatal Pathology, University of Leipzig, Germany. Electronic address: hornl@medizin.uni-leipzig.de.
authors.forename: Lars-Christian
authors.initials: LC
authors.lastname: Horn
authors.affiliation: Institute of Pathology, Division of Breast, Gynecologic & Perinatal Pathology, University of Leipzig, Germany.
authors.forename: Karolin
authors.initials: K
authors.lastname: Angermann
authors.affiliation: Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany.
authors.forename: Bettina
authors.initials: B
authors.lastname: Hentschel
authors.affiliation: Department of Obstetrics and Gynecology (Institute of Trier), University of Leipzig, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Einenkel
authors.affiliation: Institute of Pathology, Division of Breast, Gynecologic & Perinatal Pathology, University of Leipzig, Germany.
authors.forename: Anne Kathrin
authors.initials: AK
authors.lastname: Höhn
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003536:Cystadenocarcinoma / Q000473:pathology*; D003537:Cystadenoma / Q000473:pathology*; D005184:Fallopian Tube Diseases / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology
keywords: Adenoma to carcinoma sequence; Borderline tumor; Mucinous; Ovary; Papillary tubal hyperplasia; Salpingoliths; Serous; Transition