title: Results from the Belgian mantle cell lymphoma registry.
abstract: BACKGROUND
  Mantle cell lymphoma is a B-cell non-Hodgkin's lymphoma characterized by a t(11;14), resulting in overexpression of cyclin D1. Conventional chemotherapy obtains frequent (but short) remissions, leading to a poor median overall survival (OS) of 3-5 years. To obtain more information about the prevalence and current treatment of Mantle cell lymphoma (MCL) in Belgium, we collected data in a Belgian registry of MCL.
  
  
  METHODS
  All Belgian MCL patients, t(11;14) and/or cyclin D1 positive, seen in hematology departments over a one-year period (April 2013-March 2014) were included. Data about patient characteristics, histology, treatment lines, and response were compiled and retrospectively analyzed.
  
  
  RESULTS
  Four hundred and four patients were included with a median age at diagnosis of 64 years (range 23-96 years) and a male predominance (72%). For 2013, we calculated a prevalence of at least 36.2 per million and an incidence of at least 7.0 per million in the Belgian population. Characteristics at diagnosis involved lymphadenopathy (82%), splenomegaly (44%), B-symptoms (39%), and hepatomegaly (10%). Bone marrow invasion was present at diagnosis in 77%. Stage at diagnosis was advanced in the majority of cases. The median number of treatment lines was 1. Type of first line treatment included a combination of anthracyclin and cytarabine-based regimen (34%), anthracyclin (39%), and other. Rituximab was used in 88% of first line treatments. In 44% first line treatment was followed by autologous stem cell transplantation.
  
  
  CONCLUSIONS
  The analysis of this Belgian MCL registry provides insight in the epidemiology, demographics, and current treatment of our Belgian MCL population.
authors.affiliation: a Department of Hematology , UZ Leuven , Leuven , Belgium.
authors.forename: Vibeke
authors.initials: V
authors.lastname: Vergote
authors.affiliation: a Department of Hematology , UZ Leuven , Leuven , Belgium.
authors.forename: Ann
authors.initials: A
authors.lastname: Janssens
authors.affiliation: b Department of Hematology , CHU UCL Namur , Yvoir , Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: André
authors.affiliation: c Department of Hematology , CHU de Liège , Liège , Belgium.
authors.forename: Christophe
authors.initials: C
authors.lastname: Bonnet
authors.affiliation: d Department of Hematology , UZ Gent , Gent , Belgium.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Van Hende
authors.affiliation: e Department of Hematology , Cliniques universitaires Saint Luc , Brussels , Belgium.
authors.forename: Eric
authors.initials: E
authors.lastname: Van Den Neste
authors.affiliation: f Department of Hematology , AZ Groeninge , Kortrijk , Belgium.
authors.forename: Koen
authors.initials: K
authors.lastname: Van Eygen
authors.affiliation: g Department of Hematology , Institut Jules Bordet , Brussels , Belgium.
authors.forename: Marie
authors.initials: M
authors.lastname: Maerevoet
authors.affiliation: h Department of Hematology , GHdC , Charleroi , Belgium.
authors.forename: Delphine
authors.initials: D
authors.lastname: Pranger
authors.affiliation: i Department of Hematology , UZA , Antwerpen , Belgium.
authors.forename: Wilfried
authors.initials: W
authors.lastname: Schroyens
authors.affiliation: j Department of Hematology , AZ Turnhout , Turnhout , Belgium.
authors.forename: Sarah
authors.initials: S
authors.lastname: Debussche
authors.affiliation: k Department of hematology , Imeldaziekenhuis , Bonheiden , Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Maertens
authors.affiliation: l Department of Hematology , ZNA Middelheim , Antwerpen , Belgium.
authors.forename: Karolien
authors.initials: K
authors.lastname: Beel
authors.affiliation: m Department of Hematology , GZA St. Augustinus , Antwerpen , Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Lemmens
authors.affiliation: n Department of hematology , VUB , Brussels , Belgium.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Caron
authors.affiliation: o Department of Hematology , Hôpital de Jolimont , La Louvière , Belgium.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Delrieu
authors.affiliation: p Department of Hematology , AZ Nikolaas , Sint Niklaas , Belgium.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Van Den Broeck
authors.affiliation: q Department of Hematology , CHR Verviers , Verviers , Belgium.
authors.forename: Gaetan
authors.initials: G
authors.lastname: Vanstraelen
authors.affiliation: r Department of Hematology , CHR de la Citadelle , Liège , Belgium.
authors.forename: Caroline
authors.initials: C
authors.lastname: Jacquy
authors.affiliation: s Department of Hematology , AZ Delta , Roeselare , Belgium.
authors.forename: Liesbeth
authors.initials: L
authors.lastname: Schauvlieghe
authors.affiliation: t Department of Hematology , AZ Dimpna , Geel , Belgium.
authors.forename: Hade
authors.initials: H
authors.lastname: De Samblanx
authors.affiliation: u Department of Hematology , LOC , Hasselt , Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Madoe
authors.affiliation: v Department of Hematology , AZ KLINA , Antwerpen , Belgium.
authors.forename: Stef
authors.initials: S
authors.lastname: Meers
authors.affiliation: w Department of Hematology , CHR Mons-Hainaut , Mons , Belgium.
authors.forename: Dominique
authors.initials: D
authors.lastname: Boulet
authors.affiliation: a Department of Hematology , UZ Leuven , Leuven , Belgium.
authors.forename: Gregor
authors.initials: G
authors.lastname: Verhoef
authors.affiliation: x Department of Hematology , AZ Sint Jan , Brugge , Belgium.
authors.forename: Achiel
authors.initials: A
authors.lastname: Van Hoof
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018943:Anthracyclines / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001530:Belgium; D003561:Cytarabine / Q000008:administration & dosage; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D000072281:Lymphadenopathy / Q000209:etiology; D020522:Lymphoma, Mantle-Cell / Q000150:complications / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012042:Registries; D012189:Retrospective Studies; D000069283:Rituximab / Q000008:administration & dosage; D013163:Splenomegaly / Q000209:etiology; D014182:Transplantation, Autologous; D055815:Young Adult
chemical_list: D018943:Anthracyclines; D003561:Cytarabine; D000069283:Rituximab
keywords: Demographics; Epidemiology; Mantle cell lymphoma; Registry; Treatment