title: Molecular Imprinting Technology in Quartz Crystal Microbalance (QCM) Sensors.
abstract: Molecularly imprinted polymers (MIPs) as artificial antibodies have received considerable scientific attention in the past years in the field of (bio)sensors since they have unique features that distinguish them from natural antibodies such as robustness, multiple binding sites, low cost, facile preparation and high stability under extreme operation conditions (higher pH and temperature values, etc.). On the other hand, the Quartz Crystal Microbalance (QCM) is an analytical tool based on the measurement of small mass changes on the sensor surface. QCM sensors are practical and convenient monitoring tools because of their specificity, sensitivity, high accuracy, stability and reproducibility. QCM devices are highly suitable for converting the recognition process achieved using MIP-based memories into a sensor signal. Therefore, the combination of a QCM and MIPs as synthetic receptors enhances the sensitivity through MIP process-based multiplexed binding sites using size, 3D-shape and chemical function having molecular memories of the prepared sensor system toward the target compound to be detected. This review aims to highlight and summarize the recent progress and studies in the field of (bio)sensor systems based on QCMs combined with molecular imprinting technology.
authors.affiliation: Chemistry Department, Faculty of Science, Anadolu University, 26470 Eskisehir, Turkey. semir@anadolu.edu.tr.
authors.forename: Sibel
authors.initials: S
authors.lastname: Emir Diltemiz
authors.affiliation: Department of Medical Services and Techniques, Yunus Emre Vocational School of Health Services, Anadolu University, 26470 Eskisehir, Turkey. rkecili@anadolu.edu.tr.
authors.forename: Rüstem
authors.initials: R
authors.lastname: Keçili
authors.affiliation: Chemistry Department, Faculty of Science, Anadolu University, 26470 Eskisehir, Turkey. arzuersoz@anadolu.edu.tr.
authors.forename: Arzu
authors.initials: A
authors.lastname: Ersöz
authors.affiliation: Chemistry Department, Faculty of Science, Anadolu University, 26470 Eskisehir, Turkey. ridvansayy@gmail.com.|Bionkit Co. Ltd., 26470 Eskisehir, Turkey. ridvansayy@gmail.com.
authors.forename: Rıdvan
authors.initials: R
authors.lastname: Say
mesh_terms: D015374:Biosensing Techniques; D054802:Molecular Imprinting; D011108:Polymers; D011791:Quartz; D058525:Quartz Crystal Microbalance Techniques; D015203:Reproducibility of Results; D013696:Temperature
chemical_list: D011108:Polymers; D011791:Quartz
keywords: biomolecular recognition; biosensors; molecularly imprinted polymers (MIPs); quartz crystal microbalance (QCM); synthetic receptors