title: Reorganization of early visual cortex functional connectivity following selective peripheral and central visual loss.
abstract: Behavioral alterations emerging after central or peripheral vision loss suggest that cerebral reorganization occurs for both the afferented and deafferented early visual cortex (EVC). We explored the functional reorganization of the central and peripheral EVC following visual field defects specifically affecting central or peripheral vision. Compared to normally sighted, afferented central and peripheral EVC enhance their functional connectivity with areas involved in visual processing, whereas deafferented central and peripheral EVC increase their functional connectivity with more remote regions. The connectivity pattern of afferented EVC suggests adaptive changes that might enhance the visual processing capacity whereas the connectivity pattern of deafferented EVC may reflect the involvement of these regions in high-order mechanisms. Characterizing and understanding the plastic changes induced by these visual defects is essential for any attempt to develop efficient rehabilitation strategies.
authors.affiliation: Sorbonne Universités, UPMC Université Paris 06, UMR S968, Institut de la Vision, Paris, F-75012, France.|INSERM, U968, Institut de la Vision, Paris, F-75012, France.|CNRS, UMR 7210, Institut de la Vision, Paris, F-75012, France.|Centre d'investigation clinique, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC 1423, Paris, F-75012, France.
authors.forename: Norman
authors.initials: N
authors.lastname: Sabbah
authors.affiliation: Sorbonne Universités, UPMC Université Paris 06, UMR S968, Institut de la Vision, Paris, F-75012, France.|INSERM, U968, Institut de la Vision, Paris, F-75012, France.|CNRS, UMR 7210, Institut de la Vision, Paris, F-75012, France.|Centre d'investigation clinique, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC 1423, Paris, F-75012, France.|Service de neurologie, Hôpital Foch, Suresnes, France.
authors.forename: Nicolae
authors.initials: N
authors.lastname: Sanda
authors.affiliation: Sorbonne Universités, UPMC Université Paris 06, UMR S968, Institut de la Vision, Paris, F-75012, France.|INSERM, U968, Institut de la Vision, Paris, F-75012, France.|CNRS, UMR 7210, Institut de la Vision, Paris, F-75012, France.|Centre d'investigation clinique, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC 1423, Paris, F-75012, France.
authors.forename: Colas N
authors.initials: CN
authors.lastname: Authié
authors.affiliation: Sorbonne Universités, UPMC Université Paris 06, UMR S968, Institut de la Vision, Paris, F-75012, France.|INSERM, U968, Institut de la Vision, Paris, F-75012, France.|CNRS, UMR 7210, Institut de la Vision, Paris, F-75012, France.|Centre d'investigation clinique, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC 1423, Paris, F-75012, France.
authors.forename: Saddek
authors.initials: S
authors.lastname: Mohand-Saïd
authors.affiliation: Sorbonne Universités, UPMC Université Paris 06, UMR S968, Institut de la Vision, Paris, F-75012, France.|INSERM, U968, Institut de la Vision, Paris, F-75012, France.|CNRS, UMR 7210, Institut de la Vision, Paris, F-75012, France.|Centre d'investigation clinique, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC 1423, Paris, F-75012, France.|Institute of Ophthalmology, University College of London, United Kingdom.|Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.|Department of Ophthalmology, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, US.
authors.forename: José-Alain
authors.initials: JA
authors.lastname: Sahel
authors.affiliation: Sorbonne Universités, UPMC Université Paris 06, UMR S968, Institut de la Vision, Paris, F-75012, France.|INSERM, U968, Institut de la Vision, Paris, F-75012, France.|CNRS, UMR 7210, Institut de la Vision, Paris, F-75012, France.|Centre de neuroimagerie, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, F-75012, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Habas
authors.affiliation: Sorbonne Universités, UPMC Université Paris 06, UMR S968, Institut de la Vision, Paris, F-75012, France.|INSERM, U968, Institut de la Vision, Paris, F-75012, France.|CNRS, UMR 7210, Institut de la Vision, Paris, F-75012, France.|Department of Medical Neurobiology, The Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91220, Israel.|The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Jerusalem 91220, Israel.|The Cognitive Science Program, The Hebrew University of Jerusalem, Jerusalem 91220, Israel.
authors.forename: Amir
authors.initials: A
authors.lastname: Amedi
authors.affiliation: Sorbonne Universités, UPMC Université Paris 06, UMR S968, Institut de la Vision, Paris, F-75012, France.|INSERM, U968, Institut de la Vision, Paris, F-75012, France.|CNRS, UMR 7210, Institut de la Vision, Paris, F-75012, France.|Centre d'investigation clinique, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC 1423, Paris, F-75012, France.|Department of Clinical Neurosciences, Geneva University School of Medicine, Geneva, Switzerland.
authors.forename: Avinoam B
authors.initials: AB
authors.lastname: Safran
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000151:congenital* / Q000000981:diagnostic imaging / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways; D009473:Neuronal Plasticity; D012174:Retinitis Pigmentosa / Q000503:physiopathology*; D000080362:Stargardt Disease; D014793:Visual Cortex / Q000503:physiopathology*; D014794:Visual Fields; D055815:Young Adult