title: Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer's Disease.
abstract: A comprehensive intervention (CI) on patients with Alzheimer's disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cogscore) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cogscore decreased significantly. At FU2 and FU3, patients' cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences.
authors.affiliation: Center for Neurobiology of Aging, INRCA, Ancona, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Balietti
authors.affiliation: Geriatrics Operative Unit, INRCA, Fermo, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Giuli
authors.affiliation: Center for Neurobiology of Aging, INRCA, Ancona, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Fattoretti
authors.affiliation: Laboratory of Biostatistics, INRCA, Ancona, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fabbietti
authors.affiliation: Center of Socio-economic Gerontological Research, INRCA, Ancona, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Papa
authors.affiliation: Geriatrics Operative Unit, INRCA, Fermo, Italy.
authors.forename: Demetrio
authors.initials: D
authors.lastname: Postacchini
authors.affiliation: Center for Neurobiology of Aging, INRCA, Ancona, Italy.|Department of Experimental and Clinical Medicine, Section of Neuroscience and Cell Biology, Università Politecnica delle Marche, Ancona, Italy.
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Conti
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000628:therapy*; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: Alzheimer disease; brain-derived neurotrophic factor; comprehensive intervention; plasma; time