title: Comparison of gadoxetic acid-enhanced dynamic MR imaging and contrast-enhanced computed tomography for preoperative evaluation of colorectal liver metastases.
abstract: OBJECTIVE
  To evaluate the diagnostic efficacy of gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) vs. contrast-enhanced computed tomography (CE-CT) in the detection of liver metastasis in colorectal carcinoma patients.
  
  
  METHODS
  One-hundred fifty-eight consecutive patients with histopathologically confirmed colorectal carcinoma underwent EOB-MRI and CE-CT; 68 patients had 105 surgically confirmed liver metastases. Diagnostic analyses were performed according to sensitivity and positive predictive value (PPV) for liver metastasis detection in combined arterial- and hepatocyte-phase images vs. CE-CT by three readers blinded to clinical data. Diagnostic accuracy and sensitivity were evaluated using the alternative free-response receiver operating characteristic method.
  
  
  RESULTS
  The overall sensitivity of EOB-MRI (91.4%) was significantly higher than that of CE-CT (80.9%, p < 0.001); the higher sensitivity of EOB-MRI was observed especially in smaller-sized lesions (73.3 vs. 56.0% for lesions ≤1 cm; 91.9 vs. 80.8% for lesions >1 cm and ≤2 cm; 99.2 vs. 95.7% for lesions >2 cm). EOB-MRI showed a significantly greater area under the receiver operating characteristic curve (Az value = 0.970) compared with CE-CT (Az value = 0.899, p < 0.01).
  
  
  CONCLUSIONS
  EOB-MRI provided higher detectability for liver metastases, especially for smaller-sized lesions, than CE-CT in patients with colorectal carcinoma.
authors.affiliation: Department of Radiology, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Asato
authors.affiliation: Department of Radiology, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan. mtsuru@dk2.so-net.ne.jp.|Division of Diagnostic Radiology, National Cancer Center, Tokyo, Japan. mtsuru@dk2.so-net.ne.jp.
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Tsurusaki
authors.affiliation: Division of Diagnostic Radiology, National Cancer Center, Tokyo, Japan.|Department of Diagnostic Radiology, Graduate School of Medicine, Kobe University, Kobe, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Sofue
authors.affiliation: Department of Radiology, School of Medicine, Shimane University, Izumo, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hieda
authors.affiliation: Department of Radiology, School of Medicine, Shimane University, Izumo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Katsube
authors.affiliation: Department of Radiology, Faculty of Medicine, Hyogo Medical College, Nishinomiya, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kitajima
authors.affiliation: Department of Radiology, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan.
authors.forename: Takamichi
authors.initials: T
authors.lastname: Murakami
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
keywords: Gadoxetic acid; Liver; Magnetic resonance imaging; Multidetector computed tomography; Neoplasm metastasis