title: Prognostic value of blood glucose in emergency room and glycosylated hemoglobin in patients who have suffered an acute cerebro-vascular event.
abstract: OBJECTIVE
  Stress hyperglycemia has been associated with a worse prognosis in patients hospitalized in critical care units. The aim of this study is to evaluate the impact of blood glucose and glycosylated hemoglobin (HbA1c) levels on the mortality of patients suffering a acute cerebro-vascular event, and to determine if this relationship depends on the presence of diabetes.
  
  
  METHODS
  A retrospective analysis of 255 patients admitted to the ER for stroke was performed. Venous plasma glucose levels in the emergency room and HbA1c levels within the first 48hours were analyzed. The presence of diabetes was defined in terms of the patients' medical history, as well as their levels of fasting plasma glucose and HbA1c. Mortality was assessed within the first 30 months after the onset of the acute event.
  
  
  RESULTS
  28.2% of patients had diabetes. Higher mortality was observed in patients who had been admitted with plasma glucose levels≥140mg/dl (hazard ratio [HR]=2.22, 95% CI: 1.18-4.16, P=.013) after adjusting for various factors. This relationship was not confirmed in diabetic patients (HR=2.20, 95% CI: 0.66-7.40, P=.201) and was in non-diabetics (HR=2.55, 95% CI: 1.11-5.85, P=.027). In diabetics, HbA1c≥7% was not associated with poor prognosis (HR=0.68, 95% CI: 0.23-1.98, P=.475), whereas non-diabetics with admission levels of HbA1c falling within the pre-diabetes range (5.7% -6.4%) had a higher mortality (HR=2.62, 95% CI: 1.01-6.79, P=.048).
  
  
  CONCLUSIONS
  Admission hyperglycemia is associated with a worse prognosis in patients without diabetes admitted for stroke, but this relationship was not seen in diabetics. In non-diabetic patients, HbA1c levels in the pre-diabetes range is associated with higher mortality.
authors.affiliation: Servicio de Endocrinología, Complejo Hospitalario de Navarra, Pamplona, España. Electronic address: andernaga@hotmail.es.
authors.forename: Ander
authors.initials: A
authors.lastname: Ernaga Lorea
authors.affiliation: Servicio de Endocrinología, Complejo Hospitalario de Navarra, Pamplona, España.
authors.forename: María Cecilia
authors.initials: MC
authors.lastname: Hernández Morhain
authors.affiliation: Servicio de Endocrinología, Complejo Hospitalario de Navarra, Pamplona, España.
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Ollero García-Agulló
authors.affiliation: Servicio de Endocrinología, Complejo Hospitalario de Navarra, Pamplona, España.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Martínez de Esteban
authors.affiliation: Servicio de Endocrinología, Complejo Hospitalario de Navarra, Pamplona, España.
authors.forename: Ana
authors.initials: A
authors.lastname: Iriarte Beroiz
authors.affiliation: Servicio de Neurología, Complejo Hospitalario de Navarra, Pamplona, España.
authors.forename: Jaime
authors.initials: J
authors.lastname: Gállego Culleré
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D004636:Emergency Service, Hospital; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D020521:Stroke / Q000097:blood / Q000150:complications / Q000401:mortality*; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Accidente cerebrovascular; Diabetes; Glycosylated hemoglobin; Hemoglobina glucosilada; Hiperglucemia; Hyperglycemia; Mortalidad; Mortality; Stroke