title: Silver-Catalyzed Cascade Reaction of β-Enaminones and Isocyanoacetates To Construct Functionalized Pyrroles.
abstract: An unexpected silver-catalyzed cascade reaction of β-enaminones and isocyanoacetates affording functionalized pyrrole derivatives is reported. In this reaction, tautomeric equilibria of β-enaminones are utilized to generate imine partners in situ. A hypothesized sequential Mannich addition/cyclization of imine tautomers and isocyanoacetates followed by an unprecedented ring-opening of the resultant 2-imidazolines and dehydration-condensation deliver the final 1,2,4,5-tetrasubstituted pyrrole products.
authors.affiliation: Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University , Changchun 130024, China.
authors.forename: Guichun
authors.initials: G
authors.lastname: Fang
authors.affiliation: Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University , Changchun 130024, China.|School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University , Xuzhou 221116, China.
authors.forename: Jianquan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University , Changchun 130024, China.
authors.forename: Junkai
authors.identifier: 0000-0002-7714-8818
authors.initials: J
authors.lastname: Fu
authors.affiliation: Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University , Changchun 130024, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University , Changchun 130024, China.|State Key Laboratory of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Xihe
authors.initials: X
authors.lastname: Bi