title: Do you know this syndrome? Hand-foot syndrome.
abstract: Hand-foot syndrome is a common cutaneous adverse effect associated with certain systemic chemotherapy drugs. It is characterized by erythema, edema, and burning sensation, especially over palmoplantar surfaces. We report the case of an elderly patient undergoing chemotherapy after a breast cancer surgery who developed symptoms two months after the start of the regimen. There are no studies that explore specific therapies. Suggestive therapy include reducing agent dosage, increasing the interval between cycles, or even stopping chemotherapy. Emollients, analgesics, and cold packs are described as effective. After alopecia and mucositis, hand-foot syndrome is the most common adverse dermatologic reaction to chemotherapeutic agents.
authors.affiliation: Department of Dermatology and Radiotherapy, Medical School of Botucatu - Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp) - Botucatu (SP), Brazil.
authors.forename: Cintia Santos
authors.initials: CS
authors.lastname: Braghiroli
authors.affiliation: Department of Dermatology and Radiotherapy, Medical School of Botucatu - Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp) - Botucatu (SP), Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Ieiri
authors.affiliation: Department of Dermatology and Radiotherapy, Medical School of Botucatu - Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp) - Botucatu (SP), Brazil.
authors.forename: Juliana Polizel
authors.initials: JP
authors.lastname: Ocanha
authors.affiliation: Department of Pathology, Medical School of Botucatu - Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp) - Botucatu (SP), Brazil.
authors.forename: Rafael Bispo
authors.initials: RB
authors.lastname: Paschoalini
authors.affiliation: Department of Dermatology and Radiotherapy, Medical School of Botucatu - Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp) - Botucatu (SP), Brazil.
authors.forename: Hélio Amante
authors.initials: HA
authors.lastname: Miot
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D005260:Female; D060831:Hand-Foot Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006801:Humans
chemical_list: D000970:Antineoplastic Agents