title: Is Dose Deformation-Invariance Hypothesis Verified in Prostate IGRT?
abstract: To assess dose uncertainties resulting from the dose deformation-invariance hypothesis in prostate cone beam computed tomography (CT)-based image guided radiation therapy (IGRT), namely to evaluate whether rigidly propagated planned dose distribution enables good estimation of fraction dose distributions.
  
  
  
  Twenty patients underwent a CT scan for planning intensity modulated radiation therapy-IGRT delivering 80 Gy to the prostate, followed by weekly CT scans. Two methods were used to obtain the dose distributions on the weekly CT scans: (1) recalculating the dose using the original treatment plan; and (2) rigidly propagating the planned dose distribution. The cumulative doses were then estimated in the organs at risk for each dose distribution by deformable image registration. The differences between recalculated and propagated doses were finally calculated for the fraction and the cumulative dose distributions, by use of per-voxel and dose-volume histogram (DVH) metrics.
  
  
  
  For the fraction dose, the mean per-voxel absolute dose difference was <1 Gy for 98% and 95% of the fractions for the rectum and bladder, respectively. The maximum dose difference within 1 voxel reached, however, 7.4 Gy in the bladder and 8.0 Gy in the rectum. The mean dose differences were correlated with gas volume for the rectum and patient external contour variations for the bladder. The mean absolute differences for the considered volume receiving greater than or equal to dose x (Vx) of the DVH were between 0.37% and 0.70% for the rectum and between 0.53% and 1.22% for the bladder. For the cumulative dose, the mean differences in the DVH were between 0.23% and 1.11% for the rectum and between 0.55% and 1.66% for the bladder. The largest dose difference was 6.86%, for bladder V80Gy. The mean dose differences were <1.1 Gy for the rectum and <1 Gy for the bladder.
  
  
  
  The deformation-invariance hypothesis was corroborated for the organs at risk in prostate IGRT except in cases of a large disappearance or appearance of rectal gas for the rectum and large external contour variations for the bladder.
authors.affiliation: INSERM, U1099, 35000 Rennes, France; Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, France. Electronic address: antoine.simon@univ-rennes1.fr.
authors.forename: Antoine
authors.initials: A
authors.lastname: Simon
authors.affiliation: INSERM, U1099, 35000 Rennes, France; Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Le Maitre
authors.affiliation: INSERM, U1099, 35000 Rennes, France; Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Nassef
authors.affiliation: INSERM, U1099, 35000 Rennes, France; Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, France.
authors.forename: Bastien
authors.initials: B
authors.lastname: Rigaud
authors.affiliation: INSERM, U1099, 35000 Rennes, France; Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, France; Department of Radiotherapy, Centre Eugène Marquis, 35000 Rennes, France.
authors.forename: Joël
authors.initials: J
authors.lastname: Castelli
authors.affiliation: INSERM, U1099, 35000 Rennes, France; Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, France.
authors.forename: Oscar
authors.initials: O
authors.lastname: Acosta
authors.affiliation: INSERM, U1099, 35000 Rennes, France; Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Haigron
authors.affiliation: INSERM, U1099, 35000 Rennes, France; Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, France; Department of Radiotherapy, Centre Eugène Marquis, 35000 Rennes, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Lafond
authors.affiliation: INSERM, U1099, 35000 Rennes, France; Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, France; Department of Radiotherapy, Centre Eugène Marquis, 35000 Rennes, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: de Crevoisier
mesh_terms: D065638:Absorption, Radiation; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D012007:Rectum / Q000000981:diagnostic imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000000981:diagnostic imaging