title: Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis.
abstract: Mesial temporal lobe epilepsy is a serious brain disorder in adults that is often preceded by an initial brain insult, such as status epilepticus (SE), that after a latent period leads to recurrent seizures. Post-SE models are widely used for studies on epileptogenic processes. Previous findings of our laboratory suggested that the Neotropical rodents Proechimys exhibit endogenous antiepileptogenic mechanisms in post-SE models. Strong body of research supports that SE triggers a rapid and dramatic upregulation of inflammatory mediators and vascular endothelial growth factor (VEGF). In this work we found that, in the epilepsy-resistant Proechimys, hippocampal and cortical levels of inflammatory cytokines (IL-1β, IL-6, IL-10, TNF-α) and VEGF remained unchanged 24h after SE, strongly contrasting to the high levels of post-SE changes observed in Wistar rats. Furthermore, substantial differences in the brain baseline levels of these proteins were encountered between animal species studied. Since inflammatory cytokines and VEGF have been recognized as major orchestrators of the epileptogenic process, our results suggest their role in the antiepileptogenic mechanisms previously described in Proechimys.
authors.affiliation: Disciplina de Neurociência, Escola Paulista de Medicina/Universidade Federal de São Paulo, Brazil. Electronic address: carla.scorza@unifesp.br.
authors.forename: Carla A
authors.initials: CA
authors.lastname: Scorza
authors.affiliation: Disciplina de Neurociência, Escola Paulista de Medicina/Universidade Federal de São Paulo, Brazil.
authors.forename: Marcia J G
authors.initials: MJG
authors.lastname: Marques
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil; Núcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes, Mogi das Cruzes, SP, Brazil. Electronic address: sgomesilva@hotmail.com.
authors.forename: Sérgio
authors.initials: S
authors.lastname: Gomes da Silva
authors.affiliation: Disciplina de Neurociência, Escola Paulista de Medicina/Universidade Federal de São Paulo, Brazil.
authors.forename: Maria da Graça
authors.initials: MDG
authors.lastname: Naffah-Mazzacoratti
authors.affiliation: Disciplina de Neurociência, Escola Paulista de Medicina/Universidade Federal de São Paulo, Brazil.
authors.forename: Fulvio A
authors.initials: FA
authors.lastname: Scorza
authors.affiliation: Disciplina de Neurociência, Escola Paulista de Medicina/Universidade Federal de São Paulo, Brazil.
authors.forename: Esper A
authors.initials: EA
authors.lastname: Cavalheiro
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe / Q000276:immunology* / Q000378:metabolism; D006624:Hippocampus / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D008297:Male; D018721:Muscarinic Agonists / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012377:Rodentia; D013226:Status Epilepticus / Q000276:immunology* / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D016207:Cytokines; D018721:Muscarinic Agonists; D042461:Vascular Endothelial Growth Factor A; D010862:Pilocarpine
keywords: Epileptogenesis; Neuroinflammation; Proechimys; Status epilepticus