title: Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity.
abstract: OBJECTIVE
  The objectives of this study were to evaluate the serum levels of adipokines in women with fibromyalgia with and without overweight/obesity, and to correlate the adipokines levels with clinical parameters associated with fibromyalgia and adipose tissue mass (body fat).
  
  
  METHODS
  The study included 100 women divided into four groups: (a) fibromyalgia and overweight/obesity; (b) fibromyalgia and normal weight; (c) controls and overweight/obesity; and (d) controls and normal weight. Patients and controls were evaluated for clinical, anthropometric, and fibromyalgia-related parameters. Assessments included serum levels of leptin, adiponectin, monocyte chemoattractant protein-1 (MCP-1), and C-reactive protein (CRP). Levels of adipokines were further adjusted for fat mass.
  
  
  RESULTS
  Fibromyalgia patients with overweight/obesity or normal weight had no differences in clinical parameters. Unadjusted leptin levels were lower in fibromyalgia patients than controls, a finding that was more remarkable in fibromyalgia patients with overweight/obesity. Leptin levels had no correlation with clinical parameters of fibromyalgia or inflammation markers (MCP-1 and CRP), and adiponectin levels showed no difference between groups.
  
  
  CONCLUSIONS
  No correlation was observed between adjusted leptin levels and clinical parameters of fibromyalgia. Patients with fibromyalgia and overweight/obesity presented lower levels of leptin than controls with overweight/obesity.
authors.affiliation: Departamento de Medicina Interna, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil.
authors.forename: Eduardo S
authors.initials: ES
authors.lastname: Paiva
authors.affiliation: Departamento de Nutrição, UFPR, Curitiba, PR, Brasil.
authors.forename: Aline
authors.initials: A
authors.lastname: Andretta
authors.affiliation: Departamento de Nutrição, UFPR, Curitiba, PR, Brasil.
authors.forename: Emmanuelle Dias
authors.initials: ED
authors.lastname: Batista
authors.affiliation: Departamento de Nutrição, UFPR, Curitiba, PR, Brasil.
authors.forename: Márcia Maria Marques Teles
authors.initials: MMMT
authors.lastname: Lobo
authors.affiliation: University of Rome Tor Vergata, Rome, Italy.|UFPR, Curitiba, PR, Brasil.
authors.forename: Renata Costa de
authors.initials: RC
authors.lastname: Miranda
authors.affiliation: Laboratório de Imunopatologia, Hospital de Clínicas, UFPR, Curitiba, PR, Brasil.
authors.forename: Renato
authors.initials: R
authors.lastname: Nisihara
authors.affiliation: Departamento de Nutrição, UFPR, Curitiba, PR, Brasil.
authors.forename: Maria Eliana Madalozzo
authors.initials: MEM
authors.lastname: Schieferdecker
authors.affiliation: Serviço de Endocrinologia e Metabologia (SEMPR), Departamento de Medicina Interna, UFPR, Curitiba, PR, Brasil.
authors.forename: César L
authors.initials: CL
authors.lastname: Boguszewski
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D050177:Overweight / Q000097:blood* / Q000503:physiopathology; D017288:Pain Threshold; D011788:Quality of Life; D012016:Reference Values; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D055105:Waist Circumference
chemical_list: D052242:Adiponectin; D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D020738:Leptin; D002097:C-Reactive Protein