title: Diagnosis of neonatal neuroblastoma with postmortem magnetic resonance imaging.
abstract: Postmortem magnetic resonance imaging (MRI) is emerging as a valuable tool to accompany traditional autopsy and has potential for use in cases when traditional autopsy is not possible. This case report will review the use of postmortem MRI with limited tissue sampling to differentiate between metastatic neuroblastoma and hepatoblastoma which could not be clearly differentiated with prenatal ultrasound, prenatal MRI, or emergent postnatal ultrasound. The mother presented to our institution at 27 weeks gestation after an obstetric ultrasound at her obstetrician's office identified a large abdominal mass. Fetal ultrasonography and MRI confirmed the mass but were unable to differentiate between neuroblastoma and multifocal hepatoblastoma. The baby was delivered by cesarean section after nonreassuring heart tones led to an emergent cesarean section. The baby underwent decompressive laparotomy to relieve an abdominal compartment syndrome; however, the family eventually decided to withdraw life support. At this time, we performed a whole body postmortem MRI which further characterized the mass as an adrenal neuroblastoma which was confirmed with limited tissue sampling. Postmortem MRI was especially helpful in this case, as the patient's family declined traditional autopsy.
authors.affiliation: Department of Diagnostic Radiology, Beaumont Hospital, Royal Oak, MI.
authors.forename: James
authors.initials: J
authors.lastname: Davis
authors.affiliation: Department of Pediatric Surgery, Beaumont Hospital, Royal Oak, MI.
authors.forename: Nathan
authors.initials: N
authors.lastname: Novotny
authors.affiliation: Department of Anatomic Pathology, Beaumont Hospital, Royal Oak, MI.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Macknis
authors.affiliation: Department of Maternal Fetal Medicine, Beaumont Hospital, Royal Oak, MI.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Alpay-Savasan
authors.affiliation: Department of Diagnostic Radiology, Beaumont Hospital, Royal Oak, MI.
authors.forename: Luis F
authors.initials: LF
authors.lastname: Goncalves
keywords: Fetal imaging; MRI; Metastatic neuroblastoma; Postmortem imaging; Virtual autopsy