title: Electronic Support for Retrospective Analysis in the Field of Radiation Oncology: Proof of Principle Using an Example of Fractionated Stereotactic Radiotherapy of 251 Meningioma Patients.
abstract: BACKGROUND
  The purpose of this study is to verify the possible benefit of a clinical data warehouse (DWH) for retrospective analysis in the field of radiation oncology.
  
  
  METHODS
  We manually and electronically (using DWH) evaluated demographic, radiotherapy, and outcome data from 251 meningioma patients, who were irradiated from January 2002 to January 2015 at the Department of Radiation Oncology of the Erlangen University Hospital. Furthermore, we linked the Oncology Information System (OIS) MOSAIQ®to the DWH in order to gain access to irradiation data. We compared the manual and electronic data retrieval method in terms of congruence of data, corresponding time, and personal requirements (physician, physicist, scientific associate).
  
  
  RESULTS
  The electronically supported data retrieval (DWH) showed an average of 93.9% correct data and significantly (p= 0.009) better result compared to manual data retrieval (91.2%). Utilizing a DWH enables the user to replace large amounts of manual activities (668 h), offers the ability to significantly reduce data collection time and labor demand (35 h), while simultaneously improving data quality. In our case, work time for manually data retrieval was 637 h for the scientific assistant, 26 h for the medical physicist, and 5 h for the physician (total 668 h).
  
  
  CONCLUSIONS
  Our study shows that a DWH is particularly useful for retrospective analysis in the radiation oncology field. Routine clinical data for a large patient group can be provided ready for analysis to the scientist and data collection time can be significantly reduced. Furthermore, linking multiple data sources in a DWH offers the ability to improve data quality for retrospective analysis, and future research can be simplified.
authors.affiliation: Department of Radiation Oncology, Erlangen University Hospital , Erlangen , Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Rutzner
authors.affiliation: Department of Radiation Oncology, Erlangen University Hospital , Erlangen , Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Fietkau
authors.affiliation: Chair of Medical Informatics, Friedrich-Alexander-University of Erlangen-Nuremberg , Erlangen , Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ganslandt
authors.affiliation: Chair of Medical Informatics, Friedrich-Alexander-University of Erlangen-Nuremberg , Erlangen , Germany.
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Prokosch
authors.affiliation: Department of Radiation Oncology, Erlangen University Hospital , Erlangen , Germany.
authors.forename: Dorota
authors.initials: D
authors.lastname: Lubgan
keywords: MOSAIQ®; clinical data warehouse; data retrieval; meningioma; routine clinical data; secondary use of data; stereotactic radiotherapy