title: Structural Reorganization of the Vaginal Mucosa in Stress Urinary Incontinence under Conditions of Er:YAG Laser Treatment.
abstract: Structural characteristics of the vaginal mucosa in stress incontinence and its correction by IncontiLase technology were studied. Studies of vaginal biopsy specimens before the exposure showed degenerative and atrophic changes in the stratified squamous epithelium, disorganization of fibrillar structures of the intercellular matrix, and microcirculatory disorders. Studies after Er:YAG laser exposure showed signs of neocollagenogenesis and elastogenesis, foci of neoangiogenesis, reduction of epithelial degeneration and atrophy, and an increase of the fibroblast population. Morphometry showed that the volume density of blood capillaries and the thickness of the epithelial layer increased by 61.1 and 64.5%, respectively. The use of IncontiLase technology in stress incontinence led to structural reorganization of the vaginal mucosa, improving its morphology and function and alleviating the symptoms of incontinence.
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia. pathol@inbox.ru.
authors.forename: G A
authors.initials: GA
authors.lastname: Lapii
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Yakovleva
authors.affiliation: Altai State Medical University, Barnaul, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Neimark
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation / Q000379:methods*; D017078:Laser-Doppler Flowmetry; D053844:Lasers, Solid-State; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014521:Urethra / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure*; D014550:Urinary Incontinence, Stress / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D014563:Urodynamics; D014621:Vagina / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure*
keywords: Er:YAG laser; IncontiLase Laser technology; morphometry; stress urinary incontinence; vaginal biopsy