title: Accuracy of a combined insulin-like growth factor-binding protein-1/interleukin-6 test (Premaquick) in predicting delivery in women with threatened preterm labor.
abstract: OBJECTIVE
  To determine values of combinations of interleukin-6 (IL-6)/cervical native insulin-like growth factor-binding protein-1 (IGFBP-1)/total IGFBP-1 (Premaquick©) in predicting spontaneous deliveries and spontaneous exclusive preterm deliveries in women with threatened preterm labor.
  
  
  METHODS
  Women with singleton pregnancies between gestation age (GA) of 24 weeks and 36 weeks and 6 days with preterm labor were recruited during a prospective multicenter study. Premaquick© was positive when at least two of three biomarkers were positive. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were estimated for both prediction of spontaneous deliveries and spontaneous exclusive preterm deliveries.
  
  
  RESULTS
  Ninety-seven (99.0%) out of 98 women enrolled were analyzed. Based on delivery status 7/14 days post-enrollment of general study population, Premaquick© had a sensitivity of 87.1/85.7%, a specificity of 92.4/96.8%, a PPV of 84.4/93.8% and a NPV of 93.9/92.3% for prediction of spontaneous delivery. Predictive accuracy of Premaquick© test in relation to days of enrollment were: 90.7% (≤7 days) and 92.8% (≤14 days). For women enrolled at GA <35 weeks, Premaquick© had a sensitivity of 100.0/87.5%, a specificity of 94.1/96.9%, a PPV of 70.5/87.5%, a NPV of 100.0/96.9% and an accuracy of 95.0/95.0% for prediction of preterm delivery within 7/14 days of enrollment, respectively. PPV was most significantly different in both groups when outcomes were compared between 2 days and 14 days post-enrollment (P<0.001).
  
  
  CONCLUSIONS
  This novel triple biomarker model of native and total IGFBP-1 and IL-6 appears to be an accurate test in predicting spontaneous deliveries and spontaneous exclusive preterm deliveries in threatened preterm labor in singleton pregnancies.
authors.affiliation: .
authors.forename: George Uchenna
authors.initials: GU
authors.lastname: Eleje
authors.affiliation: .
authors.forename: Euzebus Chinonye
authors.initials: EC
authors.lastname: Ezugwu
authors.affiliation: .
authors.forename: Ahizechukwu Chigoziem
authors.initials: AC
authors.lastname: Eke
authors.affiliation: .
authors.forename: Lydia Ijeoma
authors.initials: LI
authors.lastname: Eleje
authors.affiliation: .
authors.forename: Joseph Ifeanyichukwu
authors.initials: JI
authors.lastname: Ikechebelu
authors.affiliation: .
authors.forename: Ifeanyichukwu Uzoma
authors.initials: IU
authors.lastname: Ezebialu
authors.affiliation: , Parklane.
authors.forename: Chukwudi Celestine
authors.initials: CC
authors.lastname: Obiora
authors.affiliation: .
authors.forename: Betrand Obi
authors.initials: BO
authors.lastname: Nwosu
authors.affiliation: .
authors.forename: Chukwuemeka Okwudili
authors.initials: CO
authors.lastname: Ezeama
authors.affiliation: .
authors.forename: Gerald Okanandu
authors.initials: GO
authors.lastname: Udigwe
authors.affiliation: .
authors.forename: Charles Ikechukwu
authors.initials: CI
authors.lastname: Okafor
authors.affiliation: , Parklane.
authors.forename: Frank Okechukwu
authors.initials: FO
authors.lastname: Ezugwu
mesh_terms: D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000032:analysis*; D015850:Interleukin-6 / Q000032:analysis*; D007752:Obstetric Labor, Premature / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies; D014626:Vaginal Smears
chemical_list: C508600:IL6 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D015850:Interleukin-6
keywords: Accuracy; IGFBP-1; IL-6; Premaquick; threatened preterm labor