title: Design Automation in Synthetic Biology.
abstract: Design automation refers to a category of software tools for designing systems that work together in a workflow for designing, building, testing, and analyzing systems with a target behavior. In synthetic biology, these tools are called bio-design automation (BDA) tools. In this review, we discuss the BDA tools areas-specify, design, build, test, and learn-and introduce the existing software tools designed to solve problems in these areas. We then detail the functionality of some of these tools and show how they can be used together to create the desired behavior of two types of modern synthetic genetic regulatory networks.
authors.affiliation: Department of Genetics, Harvard Medical School, Harvard University, Boston, Massachusetts 02115.
authors.forename: Evan
authors.initials: E
authors.lastname: Appleton
authors.affiliation: Biological Design Center, Boston University, Boston, Massachusetts 02215.|Department of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215.
authors.forename: Curtis
authors.initials: C
authors.lastname: Madsen
authors.affiliation: Biological Design Center, Boston University, Boston, Massachusetts 02215.|Department of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Roehner
authors.affiliation: Biological Design Center, Boston University, Boston, Massachusetts 02215.|Department of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215.
authors.forename: Douglas
authors.initials: D
authors.lastname: Densmore
mesh_terms: D001331:Automation; D004247:DNA / Q000235:genetics; D053263:Gene Regulatory Networks; D012984:Software; D058615:Synthetic Biology
chemical_list: D004247:DNA