title: Association between routine laboratory tests and long-term mortality among acutely admitted older medical patients: a cohort study.
abstract: Older people have the highest incidence of acute medical admissions. Old age and acute hospital admissions are associated with a high risk of adverse health outcomes after discharge, such as reduced physical performance, readmissions and mortality. Hospitalisations in this population are often by acute admission and through the emergency department. This, along with the rapidly increasing proportion of older people, warrants the need for clinically feasible tools that can systematically assess vulnerability in older medical patients upon acute hospital admission. These are essential for prioritising treatment during hospitalisation and after discharge. Here we explore whether an abbreviated form of the FI-Lab frailty index, calculated as the number of admission laboratory test results outside of the reference interval (FI-OutRef) was associated with long term mortality among acutely admitted older medical patients. Secondly, we investigate other markers of aging (age, total number of chronic diagnoses, new chronic diagnoses, and new acute admissions) and their associations with long-term mortality.
  
  
  
  A cohort study of acutely admitted medical patients aged 65 or older. Survival time within a 3 years post-discharge follow up period was used as the outcome. The associations between the markers and survival time were investigated by Cox regression analyses. For analyses, all markers were grouped by quartiles.
  
  
  
  A total of 4,005 patients were included. Among the 3,172 patients without a cancer diagnosis, mortality within 3 years was 39.9%. Univariate and multiple regression analyses for each marker showed that all were significantly associated with post-discharge survival. The changes between the estimates for the FI-OutRef quartiles in the univariate- and the multiple analyses were negligible. Among all the markers investigated, FI-OutRef had the highest hazard ratio of the fourth quartile versus the first quartile: 3.45 (95% CI: 2.83-s4.22, P < 0.001).
  
  
  
  Among acutely admitted older medical patients, FI-OutRef was strongly associated with long-term mortality. This association was independent of age, sex, and number of chronic diagnoses, new chronic diagnoses, and new acute admissions. Hence FI-OutRef could be a biomarker of advancement of aging within the acute care setting.
authors.affiliation: Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark. Henrik.Klausen@regionh.dk.
authors.forename: Henrik Hedegaard
authors.initials: HH
authors.lastname: Klausen
authors.affiliation: Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.|Department of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Janne
authors.initials: J
authors.lastname: Petersen
authors.affiliation: Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.|Department of Orthopedic Surgery, Copenhagen University Hospital, Hvidovre, Denmark.|Department of Physical Therapy, Physical Medicine & Rehabilitation Research - Copenhagen (PMR-C), Copenhagen University Hospital, Hvidovre, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bandholm
authors.affiliation: Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
authors.forename: Helle Gybel
authors.initials: HG
authors.lastname: Juul-Larsen
authors.affiliation: Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
authors.forename: Juliette
authors.initials: J
authors.lastname: Tavenier
authors.affiliation: Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
authors.forename: Jesper
authors.initials: J
authors.lastname: Eugen-Olsen
authors.affiliation: Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.|The Emergency Department, Copenhagen University Hospital, Hvidovre, Denmark.
authors.forename: Ove
authors.initials: O
authors.lastname: Andersen
mesh_terms: D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D003955:Diagnostic Tests, Routine; D004636:Emergency Service, Hospital; D005260:Female; D006304:Health Status; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012307:Risk Factors