title: [Association of lower urinary tract symptoms and testosterone deficiency in men with type 2 diabetes].
abstract: OBJECTIVE
  Type 2 diabetes mellitus, as a chronic systemic metabolic disease, is widely spread in the population of middle- aged men. Previously it has been proven the link between the presence of type 2 diabetes and the development of lower urinary tract symptoms in men. At the same time, middle-aged men are characterized by the appearance and progression of benign prostatic hyperplasia.
  
  
  METHODS
  We performed a study of middle-aged men with type 2 diabetes to determine the interrelation of micturition disorders with deficiency of serum testosterone, in respect that the pathophysiology of prostatic hyperplasia is regarded as dysmetabolic dyshormonal state. The prospective study examined 112 men with type 2 diabetes randomized by the level of total testosterone. Lower urinary tract symptoms were assessed by I-PSS questionnaire. The study of serum total PSA, uroflowmetry, transrectal prostate ultrasonography were performed.
  
  
  RESULTS
  As a result of the study the association between the severity of type 2 diabetes mellitus and the decrease in total testosterone levels was determined. The relationship of testosterone deficiency and the frequency of the presence and severity of lower urinary tract symptoms were demonstrated. The dependence of the prostate hyperplasia risks progression with the level of serum testosterone was found.
  
  
  CONCLUSIONS
  The association of testosterone deficiency with frequency and severity of lower urinary tract symptoms, partially related with benign prostatic hyperplasia and clinically defined detrusor cistopathy, has been proven. Further clinical studies are needed to determine the pathophysiological and pathomorphological features of type 2 diabetes, which determines the development of detrusor cistopathy and late onset hypigonadism.
authors.affiliation: Department of Urology and reproductive health with the course of Pediatric Urology-Andrology. Faculty training and retraining of specialists. Federal State Budgetary Educational Institution of Higher Education Rostov State Medical University of the Ministry of Healthcare of the Russian Federation.
authors.forename: M I
authors.initials: MI
authors.lastname: Kogan
authors.affiliation: Department of Urology and reproductive health with the course of Pediatric Urology-Andrology. Faculty training and retraining of specialists. Federal State Budgetary Educational Institution of Higher Education Rostov State Medical University of the Ministry of Healthcare of the Russian Federation.
authors.forename: I I
authors.initials: II
authors.lastname: Belousov
authors.affiliation: Department of Urology and reproductive health with the course of Pediatric Urology-Andrology. Faculty training and retraining of specialists. Federal State Budgetary Educational Institution of Higher Education Rostov State Medical University of the Ministry of Healthcare of the Russian Federation.
authors.forename: H S
authors.initials: HS
authors.lastname: Ibishev
authors.affiliation: Department of Urology and reproductive health with the course of Pediatric Urology-Andrology. Faculty training and retraining of specialists. Federal State Budgetary Educational Institution of Higher Education Rostov State Medical University of the Ministry of Healthcare of the Russian Federation.
authors.forename: A A
authors.initials: AA
authors.lastname: Cherniy
authors.affiliation: Department of Endocrinology with the course Pediatric Endocrinology Faculty training and retraining of specialists. Federal State Budgetary Educational Institution of Higher Education Rostov State Medical University of the Ministry of Healthcare of the Russian Federation.
authors.forename: I A
authors.initials: IA
authors.lastname: Khripun
authors.affiliation: Department of Endocrinology with the course Pediatric Endocrinology Faculty training and retraining of specialists. Federal State Budgetary Educational Institution of Higher Education Rostov State Medical University of the Ministry of Healthcare of the Russian Federation.
authors.forename: S V
authors.initials: SV
authors.lastname: Vorobyev
authors.affiliation: Department of Urology and reproductive health with the course of Pediatric Urology-Andrology. Faculty training and retraining of specialists. Federal State Budgetary Educational Institution of Higher Education Rostov State Medical University of the Ministry of Healthcare of the Russian Federation.
authors.forename: D V
authors.initials: DV
authors.lastname: Sizjakin
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000000981:diagnostic imaging; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000453:epidemiology* / Q000473:pathology; D011897:Random Allocation; D012426:Russia; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood / Q000172:deficiency*
chemical_list: D013739:Testosterone; D017430:Prostate-Specific Antigen
keywords: Type 2 diabetes mellitus; benign prostatic hyperplasia; diabetic cistopathy; lower urinary tract symptoms; testosterone deficiency