title: A meta-analysis of elemene versus DDP intrapleural injection in the treatment of malignant pleural effusion caused by lung cancer.
abstract: OBJECTIVE
  The objective of this study was to evaluate the clinical efficacy of elemene versus DDP intrapleural injection in the treatment of malignant pleural effusion caused by lung cancer by meta-analysis.
  
  
  METHODS
  PubMed (1960 ~ 2016.4), EMBASE (1980 ~ 2016.4), and CNKI (1979 ~ 2016.4) databases were searched to identify the clinical studies of elemene intrapleural injection in the treatment of lung cancer malignant pleural effusion. The odds ratio (OR) was used to evaluate the clinical efficacy of elemene in the treatment of pleural effusion compared to cisplatin (DDP).
  
  
  RESULTS
  Seven hundred and Thirty-two subjects with 14 studies were finally included in this meta-analysis. Meta-analysis demonstrated that the objective response rate in elemene group was much higher than that in DDP group (OR = 1.34, 95% confidence interval: 1.07 ~ 1.69, P < 0.05). The Begg's funnel plot and Egger's line regression test showed no statistical publication bias.
  
  
  CONCLUSIONS
  High clinical efficacy of elemene in the treatment of lung cancer malignant pleural effusion was found compared to DDP.
authors.affiliation: Department of Thoracic Surgery, Huaihe Hospital of Henan University, Kaifeng, PR China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Huaihe Hospital of Henan University, Kaifeng, PR China.
authors.forename: Haojie
authors.initials: H
authors.lastname: Wang
authors.affiliation: Nursing College of Henan University, Kaifeng, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D008175:Lung Neoplasms / Q000150:complications*; D016017:Odds Ratio; D016066:Pleural Effusion, Malignant / Q000188:drug therapy* / Q000209:etiology*; D017594:Publication Bias; D012717:Sesquiterpenes / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C038905:elemene; D002945:Cisplatin