title: Influence of Diabetes in the Development of Apical Periodontitis: A Critical Literature Review of Human Studies.
abstract: BACKGROUND
  The aim of this study was to perform a critical review of the literature that investigated the association between diabetes and apical periodontitis.
  
  
  METHODS
  An electronic search was performed on PubMed/MEDLINE, LILACS, Scientific Electronic Library Online (Scielo), and Cochrane Collaboration databases. Human studies assessing the effect of diabetes in apical periodontitis development or in healing after root canal treatment were included. The outcome was apical periodontitis.
  
  
  CONCLUSIONS
  Nine articles were included. The results presented in the literature to date are still scarce and incipient, and the evidence for such an association is not yet conclusive. However, the published results trend to converge on a positive association between diabetes and a larger number of periapical lesions.
authors.affiliation: Graduate Program in Dental Science, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil. Electronic address: tiburcioodonto@gmail.com.
authors.forename: Camilla Dos Santos
authors.initials: CD
authors.lastname: Tibúrcio-Machado
authors.affiliation: Graduate Program in Dental Science, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Mariana De Carlo
authors.initials: MC
authors.lastname: Bello
authors.affiliation: Graduate Program in Dental Science, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Maier
authors.affiliation: Graduate Program in Dental Science, Uningá, Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Carlos Frederico Brilhante
authors.initials: CF
authors.lastname: Wolle
authors.affiliation: Graduate Program in Dental Science, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil; Department of Stomatology, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Carlos Alexandre Souza
authors.initials: CA
authors.lastname: Bier
mesh_terms: D048909:Diabetes Complications; D006801:Humans; D010485:Periapical Periodontitis / Q000209:etiology*
keywords: Endodontics; hyperglycemia; periapical periodontitis