title: New cytotoxic phloroglucinol derivatives from Agrimonia pilosa.
abstract: Three new phloroglucinol derivatives, namely agripinol A-C (1-3), were isolated from Agrimonia pilosa Ledeb, along with two known ones (4-5). Their structures were characterized by spectroscopic methods, including MS and NMR spectroscopic techniques. The absolute configurations of the new compounds were unambiguously established by single crystal X-ray diffraction analyses. In the cytotoxicity assay, all compounds exhibited more potent cytotoxic activities against HCT-116, MDA-MB-231 and PC-3, as compared with the positive control fluorouracil.
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China.
authors.forename: Lan
authors.initials: L
authors.lastname: Tang
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Fu
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China.
authors.forename: Chenghua
authors.initials: C
authors.lastname: Lu
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China. Electronic address: hxrong@zjut.edu.cn.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Hou
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China.
authors.forename: Weiguang
authors.initials: W
authors.lastname: Shan
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China. Electronic address: zjnpr@zjut.edu.cn.
authors.forename: Zhajun
authors.initials: Z
authors.lastname: Zhan
mesh_terms: D031981:Agrimonia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D010696:Phloroglucinol / Q000737:chemistry* / Q000302:isolation & purification; D014961:X-Ray Diffraction
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010696:Phloroglucinol
keywords: Agrimonia pilosa; Agripinol A–C; Cytotoxicity; Phloroglucinol