title: The minimal effective dose of cis-9-cetylmyristoleate (CMO) in persons presenting with knee joint pain: A double-blind, randomized, placebo-controlled trial.
abstract: BACKGROUND
  Nutraceuticals containing cis-9-cetylmyristoleate (CMO) are used to improve knee pain despite the lack of placebo-controlled studies in humans. The aim of the study was to explore the minimal effective dose of CMO for relieving knee joint pain.
  
  
  METHODS
  Twenty-eight subjects with mild degree arthritic knee joint pain were randomized into 4 groups; groups A, B, and C that contained 100%, 80%, and 62.4% of fatty acid component with 12.5% of CMO, and control group D (starch 100%). The pain intensity, functional disability, and the Patient Global Impression of Change (PGIC) were assessed for a 12-week ingestion period.
  
  
  RESULTS
  Compared to group D (n = 6), there were significant differences in pain score in group A (n = 7, P = 0.005) and group C (n = 7, P = 0.012), but not significant in group B (n = 6, P = 0.180). Western Ontario and McMaster Universities Arthritis (WOMAC) score decreased significantly in groups A and C. The PGIC was positive in the majority (>50%) in groups A, B, and C, whereas negative in 83.3% in group D (control).
  
  
  CONCLUSIONS
  CMO is effective in alleviating knee pain in persons with mild degree arthritis of the knee joint, at an effective dose of 62.4%.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Seoul National University Hospital Department of Anesthesiology and Pain Medicine, Samsung Medical Center Department of Anesthesiology and Pain Medicine, Integrated Cancer Management Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea.
authors.forename: Sang Chul
authors.initials: SC
authors.lastname: Lee
authors.forename: Hyun Seung
authors.initials: HS
authors.lastname: Jin
authors.forename: Young
authors.initials: Y
authors.lastname: Joo
authors.forename: Yong Chul
authors.initials: YC
authors.lastname: Kim
authors.forename: Jee Youn
authors.initials: JY
authors.lastname: Moon
mesh_terms: D000328:Adult; D018771:Arthralgia / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D016896:Treatment Outcome; D014885:Waxes / Q000627:therapeutic use*
chemical_list: D014885:Waxes; C087638:cetyl myristoleate