title: Asymmetric Reaction of α-Diazomethylphosphonates with α-Ketoesters To Access Optically Active α-Diazo-β-hydroxyphosphonate Derivatives.
abstract: The first example for asymmetric reaction of diazomethylphosphonates with α-ketoesters was realized in the catalysis of hydroquinidine-derived bifunctional thiourea. A methodology was established to access a series of chiral α-diazo-β-hydroxyphosphonate derivatives containing various functional groups with high enantioselectivities and yields. The resulting products could be further transformed into chiral tertiary β-hydroxyphosphonate and α-halogenated fosfomycin derivatives, especially α-fluoride analogues.
authors.affiliation: Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University , Chongqing 400715, P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Du
authors.affiliation: Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University , Chongqing 400715, P.R. China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University , Chongqing 400715, P.R. China.
authors.forename: Yungui
authors.identifier: 0000-0002-5815-1261
authors.initials: Y
authors.lastname: Peng