title: Osteopathic Manipulative Treatment Limits Chronic Constipation in a Child with Pitt-Hopkins Syndrome.
abstract: Pitt-Hopkins Syndrome (PTHS) is a rare genetic disorder caused by insufficient expression of theTCF4gene. Children with PTHS typically present with gastrointestinal disorders and early severe chronic constipation is frequently found (75%). Here we describe the case of a PTHS male 10-year-old patient with chronic constipation in whom Osteopathic Manipulative Treatment (OMT) resulted in improved bowel functions, as assessed by the diary, the QPGS-Form A Section C questionnaire, and the Paediatric Bristol Stool Form Scale. The authors suggested that OMT may be a valid tool to improve the defecation frequency and reduce enema administration in PTHS patients.
authors.affiliation: Research Department, Istituto Superiore di Osteopatia, 20126 Milan, Italy; Department of Clinical Paediatrics & Obstetrics-Gynaecology, Istituto Superiore di Osteopatia, 20126 Milan, Italy.
authors.forename: Alessandro
authors.identifier: 0000-0003-1898-1065
authors.initials: A
authors.lastname: Aquino
authors.affiliation: Department of Clinical Paediatrics & Obstetrics-Gynaecology, Istituto Superiore di Osteopatia, 20126 Milan, Italy.
authors.forename: Mattia
authors.initials: M
authors.lastname: Perini
authors.affiliation: Department of Clinical Paediatrics & Obstetrics-Gynaecology, Istituto Superiore di Osteopatia, 20126 Milan, Italy.
authors.forename: Silvia
authors.identifier: 0000-0002-8361-9145
authors.initials: S
authors.lastname: Cosmai
authors.affiliation: Department of Clinical Paediatrics & Obstetrics-Gynaecology, Istituto Superiore di Osteopatia, 20126 Milan, Italy.
authors.forename: Silvia
authors.identifier: 0000-0002-6475-531X
authors.initials: S
authors.lastname: Zanon
authors.affiliation: Research Department, Istituto Superiore di Osteopatia, 20126 Milan, Italy.
authors.forename: Viviana
authors.initials: V
authors.lastname: Pisa
authors.affiliation: Research Department, Istituto Superiore di Osteopatia, 20126 Milan, Italy.
authors.forename: Carmine
authors.identifier: 0000-0001-7773-9717
authors.initials: C
authors.lastname: Castagna
authors.affiliation: Research Department, Istituto Superiore di Osteopatia, 20126 Milan, Italy.
authors.forename: Stefano
authors.identifier: 0000-0002-6701-7638
authors.initials: S
authors.lastname: Uberti