title: [Role of radiotherapy in stage I testicular seminomas: about 25 cases].
abstract: We conducted a retrospective, descriptive study of 25 stage I testicular seminomas to clarify the role of radiotherapy in the management of this disease. Between January 2001 and December 2009, 25 patients with stage I testicular seminoma were treated in the Radiotherapy Department at the National Institute of Oncology in Rabat. Primary orchidectomy was performed via the inguinal route. Initial staging was based on total beta-hCG dosage, alpha-fetoprotein dosage and exploration of superior diaphragmatic and sub-diaphragmatic lymph nodes using tomodensitometry. Adjuvant radiotherapy was delivered using linear accelerator. The median age was 33 years (18-52 years). Testicular tumor involved the right side in 16 patients and the left side in 9 patients. Radiotherapy was delivered to lombo-aortic lymph nodes in 18 patients, lombo-aortic and ipsilateral iliac lymph nodes in 7 patients, using 2 anterior-posterior beams, with delivery of 20-25 Gy in 10-14 fractions. Immediate tolerance was excellent. The average monitoring period was 73 months. Twenty three patients are currently alive in complete remission. One patient developed a pulmonary relapse 22 months after the end of the radiotherapy. One patient was lost to follow-up. Long-term toxicity, especially gastrointestinal toxicity, was not observed. No tumor or secondary hematologic disease was reported. Prophylactic radiotherapy remains the standard adjuvant treatment of stage I seminomas. Immediate tolerance is satisfactory and an increased risk for secondary cancer is negligible compared to the therapeutic benefit. However, strict monitoring and one cycle of carboplatin-based adjuvant chemotherapy are also effective.
authors.affiliation: Service de Radiothérapie, Institut National d'Oncologie, Université Mohamed V Rabat, Maroc.
authors.forename: Abdellah
authors.initials: A
authors.lastname: Aissa
authors.affiliation: Service de Radiothérapie, Institut National d'Oncologie, Université Mohamed V Rabat, Maroc.
authors.forename: Elamin
authors.initials: E
authors.lastname: Marnouche
authors.affiliation: Service de Radiothérapie, Institut National d'Oncologie, Université Mohamed V Rabat, Maroc.
authors.forename: Hanan
authors.initials: H
authors.lastname: Elkacemi
authors.affiliation: Service de Radiothérapie, Institut National d'Oncologie, Université Mohamed V Rabat, Maroc.
authors.forename: Tayeb
authors.initials: T
authors.lastname: Kebdani
authors.affiliation: Service de Radiothérapie, Institut National d'Oncologie, Université Mohamed V Rabat, Maroc.
authors.forename: Noureddine
authors.initials: N
authors.lastname: Benjaafar
mesh_terms: D000293:Adolescent; D000328:Adult; D017024:Chemotherapy, Adjuvant / Q000379:methods; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009919:Orchiectomy / Q000379:methods*; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000379:methods; D012074:Remission Induction; D012189:Retrospective Studies; D018239:Seminoma / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy; D013736:Testicular Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy; D016896:Treatment Outcome; D055815:Young Adult
keywords: Stage I testicular seminoma; adjuvant chemotherapy; adjuvant radiotherapy; lombo-aortic irradiation; monitoring