title: Sex differences in leptin modulate ventilation in heart failure.
abstract: Leptin modulates ventilation and circulating levels are higher in normal women than men.
  
  
  
  The aim of this study was to compare exercise ventilation and gas exchange in men and women with heart failure (HF) and their relation to circulating leptin concentration.
  
  
  
  Consecutive HF patients were studied by cardiopulmonary exercise testing and assay of circulating leptin concentration.
  
  
  
  Fifty-seven men and 20 women were similar with respect to age, BMI, NYHA class, left ventricular ejection fraction, and peak oxygen consumption (all p > 0.05). Leptin concentration was lower (10.3 ± 10 vs. 25.3 ± 16 ng/mL; p < 0.01) and peak exercise ventilatory efficiency (VE/VCO2) was higher (43 ± 10 vs. 36 ± 5; p < 0.01) in men. Leptin concentration was associated with peak exercise VE/VCO2(b = -0.35; F = 5.6; p = 0.02).
  
  
  
  Men have significantly lower circulating leptin concentration and increased ventilatory drive during exercise than women with comparable HF. In men with HF, lower leptin concentration may account for an increased ventilatory drive.
authors.affiliation: International Clinical Research Center and the Department of Anesthesiology and Intensive Care, St. Anna's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors.forename: Ivan
authors.initials: I
authors.lastname: Cundrle
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
authors.forename: Virend K
authors.initials: VK
authors.lastname: Somers
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
authors.forename: Prachi
authors.initials: P
authors.lastname: Singh
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Johnson
authors.affiliation: Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Scott
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA. Electronic address: olson.lyle@mayo.edu.
authors.forename: Lyle J
authors.initials: LJ
authors.lastname: Olson
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D011446:Prospective Studies; D012123:Pulmonary Ventilation / Q000502:physiology*; D012737:Sex Factors; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D015415:Biomarkers; D020738:Leptin
keywords: Brain natriuretic peptide; Exercise ventilation; Leptin; Sex differences; Ventilatory efficiency