title: Influence of genetic variants associated with body mass index on eating behavior in childhood.
abstract: Childhood eating behaviors are associated with body mass index (BMI). Recent genome-wide association studies have identified many single-nucleotide polymorphisms (SNPs) associated with adult and childhood BMI. This study hypothesized that these SNPs also influence eating behavior.
  
  
  
  In a population-based prospective cohort study among 3,031 children (mean age [standard deviation]: 4.0 [0.1] years), two weighted genetic risk scores, based on 15 childhood and 97 adult BMI SNPs, and ten individual appetite- and/or satiety-related SNPs were tested for association with food fussiness, food responsiveness, enjoyment of food, satiety responsiveness, and slowness in eating.
  
  
  
  The 15 SNP-based childhood BMI genetic risk score was not associated with the eating behavior subscales. The 97 SNP-based adult BMI genetic risk score was nominally associated with satiety responsiveness (β: -0.007 standard deviation, 95% confidence interval [CI] -0.013, 0.000). Of the 10 individual SNPs, rs11030104 in BDNF and rs10733682 in LMX1B were nominally associated with satiety responsiveness (β: -0.057 standard deviation, 95% CI -0.112, -0.002).
  
  
  
  These findings do not strongly support the hypothesis that BMI-associated SNPs also influence eating behavior at this age. A potential role for BMI SNPs in satiety responsiveness during childhood was observed; however, no associations with the other eating behavior subscales were found.
authors.affiliation: The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.|Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.|Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
authors.forename: Claire
authors.initials: C
authors.lastname: Monnereau
authors.affiliation: Institute of Psychology, Erasmus University, Rotterdam, the Netherlands.|Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
authors.forename: Pauline W
authors.initials: PW
authors.lastname: Jansen
authors.affiliation: Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.|Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.|Department of Psychiatry, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
authors.forename: Henning
authors.initials: H
authors.lastname: Tiemeier
authors.affiliation: The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.|Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.|Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
authors.forename: Vincent W V
authors.initials: VW
authors.lastname: Jaddoe
authors.affiliation: The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.|Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.|Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
authors.forename: Janine F
authors.initials: JF
authors.lastname: Felix
mesh_terms: D000328:Adult; D001066:Appetite / Q000235:genetics; D015992:Body Mass Index; D002648:Child; D004435:Eating / Q000235:genetics*; D005247:Feeding Behavior; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D007223:Infant; D008297:Male; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D012307:Risk Factors; D012527:Satiation