title: Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.
abstract: Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. A NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.
authors.affiliation: Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
authors.forename: Rona
authors.initials: R
authors.lastname: Chandrawati
authors.affiliation: Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
authors.forename: Jason Y H
authors.initials: JYH
authors.lastname: Chang
authors.affiliation: Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
authors.forename: Ester
authors.initials: E
authors.lastname: Reina-Torres
authors.affiliation: Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
authors.forename: Coline
authors.initials: C
authors.lastname: Jumeaux
authors.affiliation: Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Sherwood
authors.affiliation: Department of Ophthalmology, Duke University School of Medicine, Durham, NC, 27710, USA.
authors.forename: W Daniel
authors.initials: WD
authors.lastname: Stamer
authors.affiliation: Department of Chemistry and iNANO Interdisciplinary Nanoscience Center, Aarhus University, Aarhus C, 8000, Denmark.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Zelikin
authors.affiliation: Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
authors.forename: Darryl R
authors.initials: DR
authors.lastname: Overby
authors.affiliation: Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
authors.forename: Molly M
authors.initials: MM
authors.lastname: Stevens
mesh_terms: D000818:Animals; D001082:Aqueous Humor; D055162:Biocatalysis; D005901:Glaucoma; D007429:Intraocular Pressure; D051379:Mice; D009569:Nitric Oxide / Q000737:chemistry*
chemical_list: D009569:Nitric Oxide
keywords: glaucoma; layer-by-layer capsules; liposomes; nitric oxide; β-galactosidase