title: Lack of any Association between the Hogg1 Ser326Cys Polymorphism and Breast Cancer Risk: a Systematic Review And Meta-Analysis Of 18 Studies
abstract: Background: The human 8-oxoguanine DNA glycosylase (hOGG1) gene may be linked with cancer susceptibility.
  The aim of this study was to quantitatively summarize any association between the hOGG1 Ser326Cys polymorphism
  and breast cancer (BC) risk. Materials and Methods: A comprehensive search of the PubMed, Embase, and ISI web
  of knowledge databases for papers published before 1 October 2016 was conducted. Summary odds ratios (ORs) with
  corresponding 95 % confidence intervals (95 %CIs) were estimated, with fixed-effects or random-effects models when
  appropriate, to assess any association. Results: A total of 9,434 cases and 10,497 controls from 18 studies were included
  in this meta-analysis. When the eligible studies were pooled, there was no evidence found for a significant association
  between the hOGG1 Ser326Cys polymorphism and BC in in all genetic contrast models G vs. C (OR=1.19, 95% CI
  0.92– 1.53), CG vs. CC (OR = 0.97, 95% CI 0.91-1.04, p = 0.46), GG vs. CC (OR = 1.11, 95% CI 0.91-1.35, p = 0.30),
  GG + CG vs. CC (OR = 0.98, 95% CI 0.92-1.05, p = 0.67), and GG vs. CG + CC (OR = 1.22, 95% CI 0.98-1.52, p =
  0.07). According to subgroup analysis, we also did not find a significant association between the hOGG1 Ser326Cys
  polymorphism and BC risk in Asians and Caucasians considered separately. Conclusions: The current meta-analysis
  suggests that the hOGG1 Ser326Cys polymorphism is not significantly associated with BC risk.
authors.affiliation: Department of Perinatology, School of Medicine, Tehran University Medical of Sciences, Tehran. Email: hn_1364@yahoo.com
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Kamali
authors.forename: Saeed
authors.initials: S
authors.lastname: Kargar
authors.forename: Naeimeh
authors.initials: N
authors.lastname: Heiranizadeh
authors.forename: Mohammad
authors.initials: M
authors.lastname: Zare
authors.forename: Shadi
authors.initials: Sh
authors.lastname: Kargar
authors.forename: Masoud
authors.initials: M
authors.lastname: Zare Shehneh
authors.forename: Hossein
authors.initials: H
authors.lastname: Neamatzadeh
keywords: Breast cancer; 8-oxoguanine DNA glycosylase; polymorphism; meta-analysis