title: Analgesic Effect of Xenon in Rat Model of Inflammatory Pain.
abstract: The analgesic effects of inert gas xenon were examined on rats. The formalin model of inflammatory pain, tail-flick test, and hot-plate test revealed the antinociceptive effects of subanesthetizing doses of inhalation anesthetic xenon. Inhalation of 50/50 xenon/oxygen mixture moderated the nociceptive responses during acute and tonic phases of inflammatory pain.
authors.affiliation: Research Institute of General Pathology and Pathological Physiology, Moscow, Russia. mkuk57@gmail.com.|I. M. Sechenov First Moscow State Medical University, Moscow, Russia. mkuk57@gmail.com.
authors.forename: M L
authors.initials: ML
authors.lastname: Kukushkin
authors.affiliation: Research Institute of General Pathology and Pathological Physiology, Moscow, Russia.
authors.forename: S I
authors.initials: SI
authors.lastname: Igon'kina
authors.affiliation: Research Institute of General Pathology and Pathological Physiology, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Potapov
authors.affiliation: Research Institute of General Pathology and Pathological Physiology, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Potapov
mesh_terms: D000280:Administration, Inhalation; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005557:Formaldehyde; D006358:Hot Temperature; D007249:Inflammation; D008297:Male; D059225:Nociception / Q000187:drug effects* / Q000502:physiology; D010100:Oxygen / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D014978:Xenon / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D005557:Formaldehyde; D014978:Xenon; D010100:Oxygen
keywords: analgesia; formalin inflammatory pain model; rat; xenon