title: Is the intake of selective serotonin reuptake inhibitors associated with an increased risk of dental implant failure?
abstract: The aim of this retrospective study was to investigate the association between the intake of selective serotonin reuptake inhibitors (SSRIs) and the risk of dental implant failure. Patients were included if they were taking SSRIs only and no other medication, did not present any other systemic condition or compromising habits (bruxism, smoking, snuff), and complied with the use of prophylactic antibiotics for implant surgery. The multivariate generalized estimating equation (GEE) method and multilevel mixed-effects parametric survival analysis were used to test the association between SSRI exposure (predictor variable) and the risk of implant failure (outcome variable), adjusting for several potential confounders (other variables). The total number of implants with information available and meeting the necessary eligibility criteria was 931 (35 failures). These were placed in 300 patients. The implant failure rate was 12.5% for SSRI users and 3.3% for non-users (P=0.007). Kaplan-Meier analysis showed a statistically significant difference in the cumulative survival rate (P<0.001). The multivariate GEE model did not show a statistically significant association between SSRI intake and implant failure (P=0.530), nor did the multilevel model (P=0.125). It is suggested that the intake of SSRIs may not be associated with an increased risk of dental implant failure.
authors.affiliation: Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden. Electronic address: bruno.chrcanovic@mah.se.
authors.forename: B R
authors.initials: BR
authors.lastname: Chrcanovic
authors.affiliation: Clinic for Prosthodontics, Centre of Dental Specialist Care, Malmö, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Kisch
authors.affiliation: Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden; Department of Biomaterials, Gothenburg University, Göteborg, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Albrektsson
authors.affiliation: Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Wennerberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D017267:Dental Prosthesis Design; D019232:Dental Restoration Failure; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D013548:Sweden
chemical_list: D015921:Dental Implants; D017367:Selective Serotonin Reuptake Inhibitors
keywords: dental implant; implant failure; multilevel mixed-effects parametric survival analysis; multivariate generalized estimating equation analysis; selective serotonin reuptake inhibitors