title: Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes.
abstract: Oxidative stress (OS), an imbalance between free radical generation and antioxidant defence, is recognized as a key factor in the pathogenesis of adverse pregnancy outcomes. Although OS is a common future of normal pregnancy, persistent, overwhelming OS leads to consumption and decline of antioxidants, affecting placental antioxidant capacity and reducing systems. The accumulation of OS causes damage to lipids, proteins and DNA in the placental tissue that induces a form of accelerated ageing. Premature ageing of the placenta is associated with placental insufficiency that prevents the organ meeting the needs of the foetus, and as a consequence, the viability of the foetus is compromised. This review summarizes the literature regarding the role of OS and premature placental ageing in the pathophysiology of pregnancy complications.
authors.affiliation: Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NSW, Australia.|Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.|Priority Research Centre for Reproductive Science, University of Newcastle, Newcastle, NSW, Australia.
authors.forename: Zakia
authors.identifier: 0000-0003-2290-2083
authors.initials: Z
authors.lastname: Sultana
authors.affiliation: Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NSW, Australia.|Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.|Priority Research Centre for Reproductive Science, University of Newcastle, Newcastle, NSW, Australia.
authors.forename: Kaushik
authors.initials: K
authors.lastname: Maiti
authors.affiliation: Priority Research Centre for Reproductive Science, University of Newcastle, Newcastle, NSW, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Aitken
authors.affiliation: Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Morris
authors.affiliation: Faculty of Science and Information Technology, School of Design, Communication and Information Technology, University of Newcastle, Newcastle, NSW, Australia.
authors.forename: Lee
authors.initials: L
authors.lastname: Dedman
authors.affiliation: Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NSW, Australia.|Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.|Priority Research Centre for Reproductive Science, University of Newcastle, Newcastle, NSW, Australia.
authors.forename: Roger
authors.initials: R
authors.lastname: Smith
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D005260:Female; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D010920:Placenta / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011256:Pregnancy Outcome
keywords: intrauterine growth restriction; oxidative stress; placental ageing; pre-eclampsia; preterm birth; senescence; stillbirth