title: A pilot randomized trial of two cognitive rehabilitation interventions for mild cognitive impairment: caregiver outcomes.
abstract: This study aims to provide effect size estimates of the impact of two cognitive rehabilitation interventions provided to patients with mild cognitive impairment: computerized brain fitness exercise and memory support system on support partners' outcomes of depression, anxiety, quality of life, and partner burden.
  
  
  
  A randomized controlled pilot trial was performed.
  
  
  
  At 6 months, the partners from both treatment groups showed stable to improved depression scores, while partners in an untreated control group showed worsening depression over 6 months. There were no statistically significant differences on anxiety, quality of life, or burden outcomes in this small pilot trial; however, effect sizes were moderate, suggesting that the sample sizes in this pilot study were not adequate to detect statistical significance.
  
  
  
  Either form of cognitive rehabilitation may help partners' mood, compared with providing no treatment. However, effect size estimates related to other partner outcomes (i.e., burden, quality of life, and anxiety) suggest that follow-up efficacy trials will need sample sizes of at least 30-100 people per group to accurately determine significance. Copyright © 2017 John Wiley & Sons, Ltd.
authors.affiliation: Division of Psychology, Mayo Clinic Arizona, Phoenix, AZ, USA.
authors.forename: Andrea V
authors.identifier: 0000-0001-6753-2747
authors.initials: AV
authors.lastname: Cuc
authors.affiliation: Division of Psychology, Mayo Clinic Arizona, Phoenix, AZ, USA.
authors.forename: Dona E C
authors.initials: DEC
authors.lastname: Locke
authors.affiliation: Naval Hospital Jacksonville, Jacksonville, FL, USA.
authors.forename: Noah
authors.initials: N
authors.lastname: Duncan
authors.affiliation: Division of Neurocognitive Disorders, Mayo Clinic Rochester, Rochester, MN, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Fields
authors.affiliation: Department of Neurology, Mayo Clinic Arizona, Phoenix, AZ, USA.
authors.forename: Charlene Hoffman
authors.initials: CH
authors.lastname: Snyder
authors.affiliation: Division of Neurocognitive Disorders, Mayo Clinic Rochester, Rochester, MN, USA.
authors.forename: Sherrie
authors.initials: S
authors.lastname: Hanna
authors.affiliation: Division of Neurocognitive Disorders, Mayo Clinic Rochester, Rochester, MN, USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Lunde
authors.affiliation: Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Smith
authors.affiliation: Division of Psychology, Mayo Clinic Florida, Jacksonville, FL, USA.
authors.forename: Melanie
authors.initials: M
authors.lastname: Chandler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000523:psychology; D017028:Caregivers / Q000523:psychology*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D060825:Cognitive Dysfunction / Q000523:psychology / Q000534:rehabilitation*; D017281:Cost of Illness; D003863:Depression / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000534:rehabilitation*; D008875:Middle Aged; D010865:Pilot Projects; D011788:Quality of Life
keywords: behavioral intervention; caregivers; cognitive rehabilitation; mild cognitive impairment