title: Role of Oxidative Stress in Renal Transplantation: Bases for an n-3 PUFA Strategy Against Delayed Graft Function.
abstract: Renal transplantation (RT) is considered the "gold standard" treatment for end-stage renal disease patients. Efforts should be made to reduce ischaemia-reperfusion (IR) injury, which unavoidably occurs in RT as long as several clinical settings, i.e. open-heart surgeries, prosthesis implantation, among others. It is well known that IR is primarily responsible for injury associated with RT. Consequently, tissue inflammation and organ dysfunction will ensue due to the occurrence of oxidative stress (OS) in the reperfused tissue, a condition generated when endogenous antioxidant defences become overwhelmed by a massive production of reactive oxygen species. Furthermore, OS is involved in the impairment of renal function, leading to deleterious conditions such as delayed graft function (DGF), which is a common clinical expression of IR injury in RT. Omega-3 polyunsaturated fatty acids (n -3 PUFA) have been widely used in different clinical settings to counteract the deleterious effects of OS. Thus, based on the currently available literature, the central aim of this review was to propose an n-3 PUFAbased strategy targeting the key role of OS in the pathophysiology of renal IR injury in order to encourage protection against the occurrence of DGF.
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago. Chile.
authors.forename: Camilo G
authors.initials: CG
authors.lastname: Sotomayor
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago. Chile.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Cortés
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago. Chile.
authors.forename: Juan Guillermo
authors.initials: JG
authors.lastname: Gormaz
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago. Chile.
authors.forename: Sergio
authors.initials: S
authors.lastname: Vera
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago. Chile.
authors.forename: Matías
authors.initials: M
authors.lastname: Libuy
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago. Chile.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Valls
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70058, Santiago. Chile.
authors.forename: Ramón
authors.initials: R
authors.lastname: Rodrigo
mesh_terms: D000818:Animals; D051799:Delayed Graft Function / Q000188:drug therapy*; D015525:Fatty Acids, Omega-3 / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D016030:Kidney Transplantation; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D015525:Fatty Acids, Omega-3
keywords: Oxidative stress; delayed
  graft function; ischaemia-reperfusion injury; omega 3; reactive oxygen species; renal transplantation