title: Prognostic factors for survival in patients with pT1 N+ or T2-3 N0 gastric cancer in Japan.
abstract: BACKGROUND
  The outcome for pT1 N+ or pT2-3 N0 gastric cancer is favourable, but some patients suffer from recurrent disease. The aim of this study was to identify prognostic factors in patients with pT1 N+ or pT2-3 N0 gastric cancer.
  
  
  METHODS
  This was a multicentre, retrospective cohort study. All patients with pT1 N+ or pT2-3 N0 gastric cancer who underwent curative gastrectomy at five high-volume, specialized cancer centres in Japan between 2000 and 2008 were included. Demographic, clinical, surgical and pathological data were collected. Independent prognostic factors were identified using a Cox proportional hazards regression model.
  
  
  RESULTS
  Some 1442 patients were included. The 5-year overall survival rate for patients with pT1 N+ or pT2-3 N0 gastric cancer was 92·0 per cent. Multivariable analysis for overall survival identified age (hazard ratio (HR) 2·67, 95 per cent c.i. 2·09 to 3·43), sex (HR 0·57, 0·39 to 0·83) and clinical tumour depth (cT) (HR 1·45, 1·06 to 1·98) as independent prognostic factors.
  
  
  CONCLUSIONS
  Survival of patients with pT1 N+ or pT2-3 N0 gastric cancer is good. Age 65 years or above, male sex and cT2-4 category are associated with worse overall survival.
authors.affiliation: Division of Gastric Surgery, Shizuoka Cancer Centre, Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tokunaga
authors.affiliation: Department of Gastroenterological Surgery, Aichi Cancer Centre Hospital, Aichi, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.affiliation: Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Kanagawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshikawa
authors.affiliation: Department of Gastroenterological Surgery, Cancer Institute Ariake Hospital, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nunobe
authors.affiliation: Department of Gastric Surgery, National Cancer Centre Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fukagawa
authors.affiliation: Department of Gastroenterological Surgery, Aichi Cancer Centre Hospital, Aichi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Misawa
authors.affiliation: Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Kanagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Cho
authors.affiliation: Department of Gastric Surgery, National Cancer Centre Hospital, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Katai
authors.affiliation: Department of Gastroenterological Surgery, Cancer Institute Ariake Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sano
authors.affiliation: Division of Gastric Surgery, Shizuoka Cancer Centre, Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Terashima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate