title: [Advances of Studies on Platelet GPVI as Antithrombotic Target -Review].
abstract: Platelet activation is a crucial step in both physiological hemostasis and pathological thrombosis, which is an important mean to prevent and treat thrombotic diseases by inhibition of platelet activation. The current clinical antithrombotic therapy showed a high efficiency, but at risk of bleeding. Platelet glycoprotein VI (GPVI) is a platelet-specific receptor and its binding with collagen is critical for platelet activation. GPVI antagonists were shown to effectively inhibit thrombosis and inflammation without influence on normal hemostasis. As a novel target for antithrombotic therapy, it ideally combines efficacy with safety. This review summarizes the recent advances of studies on GPVI structure, function and its role in hemostasis, thrombosis, and anti-GPVI agents. The potential clinical strategies of antiplatelet drugs targeting GPVI are discussed so as to provide a reliable regimen for thrombotic diseases.
authors.affiliation: Institute of Hematology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Li
authors.affiliation: Institute of Hematology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China.
authors.forename: Jian-Lin
authors.initials: JL
authors.lastname: Qiao
authors.affiliation: Institute of Hematology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China. E-mail: lihmd@163.com.
authors.forename: Kai-Lin
authors.initials: KL
authors.lastname: Xu
mesh_terms: D001792:Blood Platelets; D006470:Hemorrhage; D006487:Hemostasis; D006801:Humans; D015539:Platelet Activation; D010980:Platelet Membrane Glycoproteins; D013927:Thrombosis / Q000188:drug therapy*
chemical_list: D010980:Platelet Membrane Glycoproteins