title: Digestive and urologic hemorrhage after intravenous thrombolysis for acute ischemic stroke: Data from a Chinese stroke center.
abstract: Objective Intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) is considered the most effective treatment method for AIS; however, it is associated with a risk of hemorrhage. We analyzed the risk factors for digestive and urologic hemorrhage during rt-PA therapy. Methods We retrospectively analyzed patients with AIS who underwent intravenous thrombolysis with rt-PA during a 5-year period in a Chinese stroke center. Data on the demographics, medical history, laboratory test results, and clinical outcomes were collected. Results 338 patients with AIS were eligible and included. Logistic regression multivariate analysis showed that gastric catheter was significantly correlated with digestive hemorrhage, while age and urinary catheter were significantly correlated with urologic hemorrhage. Most hemorrhagic events were associated with catheterization after 1 to 24 hours of rt-PA therapy. Conclusions In summary, gastric and urinary catheters were correlated with digestive and urologic hemorrhage in patients with AIS undergoing rt-PA therapy. Well-designed controlled studies with large samples are required to confirm our findings.
authors.affiliation: 1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
authors.affiliation: 1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: 2 Department of Nursing, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.affiliation: 1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Haiqing
authors.initials: H
authors.lastname: Song
authors.affiliation: 1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: 1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
mesh_terms: D061605:Administration, Intravenous; D000368:Aged; D044466:Asian People; D002545:Brain Ischemia / Q000188:drug therapy* / Q000208:ethnology / Q000473:pathology; D057785:Catheters / Q000009:adverse effects*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis* / Q000208:ethnology / Q000209:etiology / Q000503:physiopathology; D006417:Hematuria / Q000175:diagnosis* / Q000208:ethnology / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000188:drug therapy* / Q000208:ethnology / Q000473:pathology; D015912:Thrombolytic Therapy / Q000379:methods; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: Acute ischemic stroke; intravenous thrombolysis; peripheral hemorrhage; recombinant tissue plasminogen activator; risk factor