title: Plasticity of Renin Cells in the Kidney Vasculature.
abstract: During development, renin cells are precursors for arteriolar smooth muscle, mesangial cells, and interstitial pericytes. Those seemingly differentiated descendants retain the memory to re-express renin when there is a threat to homeostasis. Understanding how such molecular memory is constructed and regulated would be crucial to comprehend cell identity which is, in turn, intimately linked to homeostasis.
authors.affiliation: University of Virginia School of Medicine, Child Health Research Center, 409 Lane Road, MR4 Building Room 2001, Charlottesville, VA, 22908, USA. rg@virginia.edu.
authors.forename: R Ariel
authors.initials: RA
authors.lastname: Gomez
authors.affiliation: University of Virginia School of Medicine, Child Health Research Center, 409 Lane Road, MR4 Building Room 2001, Charlottesville, VA, 22908, USA.
authors.forename: Maria Luisa S Sequeira
authors.initials: ML
authors.lastname: Lopez
mesh_terms: D000818:Animals; D000066670:Cell Plasticity; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007606:Juxtaglomerular Apparatus / Q000166:cytology* / Q000502:physiology; D007668:Kidney / Q000098:blood supply*; D012083:Renin / Q000502:physiology*
chemical_list: D012083:Renin
keywords: Cell fate; Cell identity; Cell memory; Cell number; Recruitment