title: Effectiveness of contrast-enhanced ultrasound and serum liver enzyme measurement in detection and classification of blunt liver trauma.
abstract: Objective This study was performed to identify the correlation between contrast-enhanced ultrasound (CEUS) and contrast-enhanced multidetector computed tomography (CE-MDCT) as well as the correlation between serum liver enzyme concentrations and CE-MDCT in classification of the severity of blunt hepatic trauma using CE-MDCT as a reference standard. Materials and methods A blunt liver trauma model was created using 20 rabbits, and CE-MDCT, CEUS, and serum liver enzyme assays were performed. A radiologist and an ultrasound physician independently evaluated the degree of liver trauma. The diagnostic performance of CEUS and serum liver enzyme measurements was compared with that of CE-MDCT using Spearman's correlation analysis and Pearson's correlation analysis, respectively. Results Spearman's rank correlation coefficient between the CEUS-based classification and CE-MDCT was 0.888. The aspartate aminotransferase and lactate dehydrogenase concentrations and the aspartate aminotransferase/alanine aminotransferase ratio were positively correlated with the grade of liver injury; Pearson's correlation coefficients were 0.664, 0.704, and 0.503, respectively. The gamma-glutamyltransferase concentration had a significantly negative correlation with the grade of liver injury (r = -0.467). Conclusions CEUS and serum liver enzyme measurement exhibited high consistency with CE-MDCT for both detection and grading of intraparenchymal lesions in blunt liver trauma. These techniques may permit more accurate diagnosis of liver trauma.
authors.affiliation: 1 Department of Ultrasound, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, China.
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Zhao
authors.affiliation: 1 Department of Ultrasound, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Tian
authors.affiliation: 2 Department of Radiology, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, China.
authors.forename: Le-Tian
authors.initials: LT
authors.lastname: Zhang
authors.affiliation: 1 Department of Ultrasound, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: 1 Department of Ultrasound, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Bi
authors.affiliation: 1 Department of Ultrasound, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, China.
authors.forename: Jia-Ying
authors.initials: JY
authors.lastname: He
authors.affiliation: 1 Department of Ultrasound, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Zhang
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003287:Contrast Media / Q000008:administration & dosage; D004195:Disease Models, Animal; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000000981:diagnostic imaging* / Q000201:enzymology* / Q000293:injuries / Q000473:pathology; D008297:Male; D061330:Multidetector Computed Tomography; D011817:Rabbits; D015599:Trauma Severity Indices; D014463:Ultrasonography / Q000379:methods; D014949:Wounds, Nonpenetrating / Q000097:blood* / Q000000981:diagnostic imaging* / Q000473:pathology; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Contrast-enhanced ultrasound; contrast-enhanced multidetector computed tomography; liver enzyme; liver trauma