title: Soy milk versus simvastatin for preventing atherosclerosis and left ventricle remodeling in LDL receptor knockout mice.
abstract: Functional food intake has been highlighted as a strategy for the prevention of cardiovascular diseases by reducing risk factors. In this study, we compared the effects of oral treatment with soy milk and simvastatin on dyslipidemia, left ventricle remodeling and atherosclerotic lesion of LDL receptor knockout mice (LDLr-/-) fed a hyperlipidic diet. Forty 3-month old male LDLr-/- mice were distributed into four groups: control group (C), in which animals received standard diet; HL group, in which animals were fed a hyperlipidic diet; HL+SM or HL+S groups, in which animals were submitted to a hyperlipidic diet plus soy milk or simvastatin, respectively. After 60 days, both soy milk and simvastatin treatment prevented dyslipidemia, atherosclerotic lesion progression and left ventricle hypertrophy in LDLr-/- mice. These beneficial effects of soy milk and simvastatin were associated with reduced oxidative stress and inflammatory state in the heart and aorta caused by the hyperlipidic diet. Treatment with soy milk was more effective in preventing HDLc reduction and triacylglycerol and VLDLc increase. On the other hand, simvastatin was more effective in preventing an increase in total cholesterol, LDLc and superoxide production in aorta, as well as CD40L both in aorta and left ventricle of LDLr-/-. In conclusion, our results suggest a cardioprotective effect of soy milk in LDLr-/- mice comparable to the well-known effects of simvastatin.
authors.affiliation: Unidade Acadêmica de Serra Talhada, Universidade Federal Rural de Pernambuco, Serra Talhada, PE, Brasil.|Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade de Campinas, Campinas, SP, Brasil.
authors.forename: L
authors.initials: L
authors.lastname: Santos
authors.affiliation: Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade de Campinas, Campinas, SP, Brasil.
authors.forename: A P
authors.initials: AP
authors.lastname: Davel
authors.affiliation: Instituto Federal do Sul de Minas, Muzambinho, MG, Brasil.
authors.forename: T I R
authors.initials: TI
authors.lastname: Almeida
authors.affiliation: Instituto Federal do Sul de Minas, Muzambinho, MG, Brasil.
authors.forename: M R
authors.initials: MR
authors.lastname: Almeida
authors.affiliation: Departamento de Anatomia, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, MG, Brasil.
authors.forename: E A
authors.initials: EA
authors.lastname: Soares
authors.affiliation: Departamento de Anatomia, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, MG, Brasil.
authors.forename: G J M
authors.initials: GJ
authors.lastname: Fernandes
authors.affiliation: Departmento de Biomedicina, Universidade José do Rosário Vellano, Alfenas, MG, Brasil.
authors.forename: S F
authors.initials: SF
authors.lastname: Magalhães
authors.affiliation: Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, ES, Brasil.
authors.forename: V G
authors.initials: VG
authors.lastname: Barauna
authors.affiliation: Departmento de Tecnologia, Ciência e Educação, Instituto Federal do Sul de Minas, Machado, MG, Brasil.|Departamento de Fisiologia, Universidade José do Rosário Vellano, Alfenas, MG, Brasil.
authors.forename: J A D
authors.initials: JA
authors.lastname: Garcia
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D050197:Atherosclerosis / Q000517:prevention & control*; D004032:Diet; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D011973:Receptors, LDL / Q000097:blood*; D019821:Simvastatin / Q000008:administration & dosage*; D041942:Soy Milk / Q000008:administration & dosage*; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D000924:Anticholesteremic Agents; D011973:Receptors, LDL; D019821:Simvastatin