title: [Dermatoses and herpes superinfection: A retrospective study of 34 cases].
abstract: BACKGROUND
  Although varicelliform Kaposi eruption is a well-known complication of dermatoses, it has not been widely investigated.
  
  
  OBJECTIVE
  To investigate features of dermatoses and herpes superinfection in patients hospitalized in a dermatology department.
  
  
  METHODS
  We performed a single-centre, retrospective study between 2008 and 2014 that included cases of Kaposi varicelliform eruptions defined by positive PCR of an unconventional site of herpetic recurrence in a setting of active dermatitis. A record was compiled of each case giving details of the history, clinical and laboratory findings, therapeutic data and outcome.
  
  
  RESULTS
  Thirty-four cases of Kaposi varicelliform eruptions in 30 subjects were studied. Mean age at diagnosis was 63.3±24.2 years. The underlying dermatoses were as follows: 7 pemphigus, 6 bullous pemphigoid, 3 cicatricial pemphigoid, 3 atopic dermatitis, 1 Darier disease, and 14 other dermatoses. Patients presented with skin (94.1 %) or mucous membrane lesions (62 %), mostly erosive (79 %), vesicular (27 %) or bullous (41 %), often painful (56 %) or pruritic (29 %). At diagnosis, 41.2 % were undergoing systemic immunotherapy and 24 % were on topical corticosteroids. PCR was positive for HSV1 in 20 cases and for HSV2 in 4 cases, and indeterminate in 10 cases. Lymphocytopenia was seen in 59 % of cases. The majority of patients received treatment. Nine patients experienced at least one relapse.
  
  
  CONCLUSIONS
  Our study confirms the over-representation not only of the expected dermatoses (pemphigus and atopic dermatitis), but also of others such as pemphigoid and acute dermatoses; these results should be investigated in a more systematic prospective study.
authors.affiliation: Service de dermatologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris (AP-HP), pavillon Tarnier, 89, rue d'Assas, 75006 Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Seta
authors.affiliation: Service de dermatologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris (AP-HP), pavillon Tarnier, 89, rue d'Assas, 75006 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Fichel
authors.affiliation: Service de virologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris (AP-HP), 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Méritet
authors.affiliation: Unité d'information médicale, hôpital Cochin, HUPC, Assistance publique-Hôpitaux de Paris (AP-HP), 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Bouam
authors.affiliation: Service de dermatologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris (AP-HP), pavillon Tarnier, 89, rue d'Assas, 75006 Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Franck
authors.affiliation: Service de dermatologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris (AP-HP), pavillon Tarnier, 89, rue d'Assas, 75006 Paris, France.
authors.forename: M-F
authors.initials: MF
authors.lastname: Avril
authors.affiliation: Service de dermatologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris (AP-HP), pavillon Tarnier, 89, rue d'Assas, 75006 Paris, France. Electronic address: nicolas.dupin@aphp.fr.
authors.forename: N
authors.initials: N
authors.lastname: Dupin
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D016867:Immunocompromised Host; D007297:Inpatients; D007617:Kaposi Varicelliform Eruption / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012871:Skin Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D015163:Superinfection; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D005938:Glucocorticoids
keywords: Dermatose; Dermatosis; Eczema herpeticum; HSV; Herpes; Herpès; Kaposi varicelliform eruption; Surinfection