title: Intermittent facial spasms as the presenting sign of a recurrent pleomorphic adenoma.
abstract: The intimate anatomical relationship of the facial nerve to the parotid parenchyma has a significant influence on the presenting signs and symptoms, diagnosis and treatment of parotid neoplasms. However, to our knowledge, hyperactivity of this nerve, presenting as facial spasm, has never been described as the presenting sign or symptom of a parotid malignancy. We report a case of carcinoma arising in a recurrent pleomorphic adenoma of the left parotid gland (i.e., carcinomaex pleomorphicadenoma) that presented with hemifacial spasms. We outline the differential diagnosis of hemifacial spasm as well as a proposed pathophysiology. Facial paralysis, lymph node enlargement, skin involvement, and pain have all been associated with parotid malignancies. To date the development of facial spasm has not been reported with parotid malignancies. The most common etiologies for hemifacial spasm are vascular compression of the ipsilateral facial nerve at the cerebellopontine angle (termed primary or idiopathic) (62%), hereditary (2%), secondary to Bell's palsy or facial nerve injury (17%), and hemifacial spasm mimickers (psychogenic, tics, dystonia, myoclonus, myokymia, myorthythmia, and hemimasticatory spasm) (17%). Hemifacial spasm has not been reported in association with a malignant parotid tumor but must be considered in the differential diagnosis of this presenting symptom.
authors.affiliation: Rosalie A Machado, Sami P Moubayed, Mark L Urken, Thyroid, Head and Neck Cancer Foundation, New York, NY 10003, United States.
authors.forename: Rosalie A
authors.initials: RA
authors.lastname: Machado
authors.affiliation: Rosalie A Machado, Sami P Moubayed, Mark L Urken, Thyroid, Head and Neck Cancer Foundation, New York, NY 10003, United States.
authors.forename: Sami P
authors.initials: SP
authors.lastname: Moubayed
authors.affiliation: Rosalie A Machado, Sami P Moubayed, Mark L Urken, Thyroid, Head and Neck Cancer Foundation, New York, NY 10003, United States.
authors.forename: Azita
authors.initials: A
authors.lastname: Khorsandi
authors.affiliation: Rosalie A Machado, Sami P Moubayed, Mark L Urken, Thyroid, Head and Neck Cancer Foundation, New York, NY 10003, United States.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Hernandez-Prera
authors.affiliation: Rosalie A Machado, Sami P Moubayed, Mark L Urken, Thyroid, Head and Neck Cancer Foundation, New York, NY 10003, United States.
authors.forename: Mark L
authors.initials: ML
authors.lastname: Urken
keywords: Benign mixed parotid tumor; Facial spasm; Pleomorphic adenoma; Reconstructive surgery; Salivary glands