title: Epidemiology of Nontuberculous Mycobacterial Lung Disease and Tuberculosis, Hawaii, USA.
abstract: Previous studies found Hawaiians and Asian-Americans/Pacific Islanders to be independently at increased risk for nontuberculous mycobacterial pulmonary disease (NTMPD) and tuberculosis (TB). To better understand NTM infection and TB risk patterns in Hawaii, USA, we evaluated data on a cohort of patients in Hawaii for 2005-2013. Period prevalence of NTMPD was highest among Japanese, Chinese, and Vietnamese patients (>300/100,000 persons) and lowest among Native Hawaiians and Other Pacific Islanders (50/100,000). Japanese patients were twice as likely as all other racial/ethnic groups to have Mycobacterium abscessus isolated (adjusted odds ratio 2.0, 95% CI 1.2-3.2) but were not at increased risk for infection with other mycobacteria species. In contrast, incidence of TB was stable and was lowest among Japanese patients (no cases) and highest among Filipino, Korean, and Vietnamese patients (>50/100,000). Substantial differences exist in the epidemiology of NTMPD by race/ethnicity, suggesting behavioral and biologic factors that affect disease susceptibility.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Adjemian
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Frankland
authors.forename: Yihe G
authors.initials: YG
authors.lastname: Daida
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Honda
authors.forename: Kenneth N
authors.initials: KN
authors.lastname: Olivier
authors.forename: Adrian
authors.initials: A
authors.lastname: Zelazny
authors.forename: Stacey
authors.initials: S
authors.lastname: Honda
authors.forename: D Rebecca
authors.initials: DR
authors.lastname: Prevots
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D008171:Lung Diseases / Q000453:epidemiology / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000453:epidemiology / Q000382:microbiology*; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology*; D055815:Young Adult
keywords: Hawaii; Hawai’i; TB; United States; bacterial infections; epidemiology; nontuberculous mycobacteria; pulmonary; tuberculosis and other mycobacteria