title: Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies.
abstract: A growing number of bunyaviruses are known to cause viral hemorrhagic fever (VHF), a severe febrile illness which can progress to hypovolemic shock and multi-organ failure and is characterized by hematologic abnormalities and vascular leak. At present, there are no approved vaccines or antiviral therapies to effectively prevent or treat VHF caused by pathogenic bunyaviruses. Advances in the modeling of bunyaviral infections have facilitated efforts towards the development of novel post-exposure prophylactic and therapeutic countermeasures, several of which may some day be approved for human use. Here, we review recent progress in animal models of severe bunyaviral infections essential to this mission, as well as promising antivirals and biologicals that are at various stages of the development process.
authors.affiliation: Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, 84326, USA. brian.gowen@usu.edu.
authors.forename: Brian B
authors.initials: BB
authors.lastname: Gowen
authors.affiliation: Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, 84326, USA.
authors.forename: Brady T
authors.initials: BT
authors.lastname: Hickerson
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D001685:Biological Factors / Q000627:therapeutic use*; D002044:Bunyaviridae Infections / Q000628:therapy* / Q000821:virology; D006224:Cricetinae; D004195:Disease Models, Animal; D006476:Orthohantavirus / Q000302:isolation & purification; D018778:Hantavirus Infections / Q000628:therapy; D006479:Hemorrhagic Fever, Crimean / Q000628:therapy; D006482:Hemorrhagic Fevers, Viral / Q000628:therapy* / Q000821:virology; D006801:Humans; D051379:Mice; D016851:Orthobunyavirus / Q000302:isolation & purification; D056990:Post-Exposure Prophylaxis / Q000379:methods; D051381:Rats; D012295:Rift Valley Fever / Q000628:therapy; D014765:Viral Vaccines
chemical_list: D000998:Antiviral Agents; D001685:Biological Factors; D014765:Viral Vaccines
keywords: Crimean-Congo hemorrhagic fever; Rift valley fever; antiviral; bunyavirus; hantavirus; severe fever with thrombocytopenia syndrome