title: Mesenchymal stem cells as potential therapeutic approaches in celiac disease.
abstract: As a chronic immune complication, celiac disease has a broad spectrum of clinical manifestations and gluten ingestion as an external trigger will induce the onset of this disease in genetically predisposed individuals. Because of the complex nature of celiac disease and various cascades of immunological pathways, therapies which are tend to target a single pathway or factor, often have unsatisfactory results. Thus, it should be considered that the new emerging area of cellular therapy by targeting multiple pathways may hold the key for treating celiac affected patients with complicated forms of this disease. The aim of this review is to discuss different pathways which are affected by celiac disease and to compare how various strategies, mainly cellular therapies, can regulate these pathways.
authors.affiliation: Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Moheb-Alian
authors.affiliation: Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Flora
authors.initials: F
authors.lastname: Forouzesh
authors.affiliation: Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rostami-Nejad
authors.affiliation: Department of Gastroenterology Milton Keynes University Hospital, United Kingdom.
authors.forename: Kamran
authors.initials: K
authors.lastname: Rostami
keywords: Celiac disease; Cell therapy; Immunological pathways