title: [Clinical Value of18F-FDG PET/CT for Patients with B Cell Lymphoma-Associated Hemophagocytic Syndrome].
abstract: OBJECTIVE
  To investigate the clinical value of18F-FDG PET/CT for patients with B cell lymphoma-associated hemophagocytic syndrome.
  
  
  METHODS
  The clinical characteristics, laboratory parameters and18F-FDG PET/CT data of 23 newly diagnosed patients sufferred from B cell lymphoma-associated hemophagocytic syndrome were retrospectively analyzed. The correlation between PET and laboratory parameters were determined using Spearman correlation test. The prognostic factors were analyzed by the Kaplan-Meier method.
  
  
  RESULTS
  23 patients were all examined by18F-FDG PET/CT before chemotherapy, the18F-FDG uptake of spleen positively correlated with neutrophil count and hemoglobin content (r=0.588, P=0.035;r=0.699, P=0.008), respectively, and the18F-FDG uptake of bone marrow positively correlated with neutrophil count only (r=0.691, P=0.009). Among all the clinical or laboratorial parameters and18F-FDG PET/CT, only PET parameter was poor factor affecting prognosis of patients with B cell lymphoma-associated hemophagocytic syndrome. Out of 6 patients received PET/CT scans after 6 cycles of treatment, the 5 patients with negative PET/CT survived, and one patient with positive result died.
  
  
  CONCLUSIONS
  Baseline18F-FDG PET/CT may provide prognostic information for the management of patients with B cell lymphoma-associated hemophagocytic syndrome, and the data of18F-FDG PET/CT before chemotherapy may predict the pregnosis of the patients with negative results, and the negative PET/CT results after chemotherapy betokens a better prognosis of patients.
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Chong-Yang
authors.initials: CY
authors.lastname: Ding
authors.affiliation: Department of Radiology, Zhejiang Taizhou Central Hospital, Taizhou 318000, Zhejiang Province, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Liu
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Yang-Yang
authors.initials: YY
authors.lastname: Li
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Yang
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. E-mail: litiannv@126.com.
authors.forename: Tian-Nv
authors.initials: TN
authors.lastname: Li
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications / Q000000981:diagnostic imaging*; D016393:Lymphoma, B-Cell / Q000150:complications*; D000072078:Positron Emission Tomography Computed Tomography; D049268:Positron-Emission Tomography; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18