title: Clinical Outcomes after Surgery for Linitis Plastica of the Stomach: Analysis of a Population Cancer Registry.
abstract: Linitis plastica (LP), a subset of gastric adenocarcinoma (GA), has been considered as a fatal disease with few management options. Little evidence has been reported regarding the role for surgical therapy in treating LP. A retrospective review of GA patients with LP from the surveillance, epidemiology, and end results database (2004-2009) was performed. 29,440 patients with GA were identified, of whom 948 (3.2%) had LP. After matching for American Joint Commission on Cancer (AJCC) stage, LP patients had significantly worse 5-year disease specific survival (DSS) compared with GA (6 vs 34%, P < 0.001). For potentially resectable LP patients (i.e., stage I-III), 5-year DSS was 0 per cent for no treatment and for radiation therapy alone, 18 per cent for both and surgery and radiation, and 20 per cent for surgery alone(P < 0.001). LP is a marker of poor survival in patients with GA. However, surgical resection provides the best oncologic outcomes in these patients with a 20 per cent 5-year DSS in patients with loco-regional disease.
authors.affiliation: Surgery, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Chang
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Lara
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Gray
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Pockaj
authors.forename: Nabil
authors.initials: N
authors.lastname: Wasif
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D008039:Linitis Plastica / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D018426:SEER Program; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology