title: Posterior reversible encephalopathy syndrome (PRES) with sub-arachnoid haemorrhage after bevacizumab and 5-FU.
abstract: PRES is a neurological syndrome characterised by reversible subcortical vasogenic brain oedema in patients with acute neurological signs and symptoms. It occurs in the context of fluctuations in blood pressure, renal failure, autoimmune disorders, eclamptic syndromes and with use of cytotoxic drugs. We present the case of a 60year old female with advanced bowel cancer who was admitted with seizures and sub-arachnoid haemorrhage, with radiographic features of PRES, shortly after receiving bevacizumab (Avastin), a VEGF-inhibitor.
authors.affiliation: Department of Neurology, Royal North Shore Hospital, St Leonards, Sydney, NSW 2006, Australia. Electronic address: jennifer.massey@hotmail.com.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Massey
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000068258:Bevacizumab / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D005770:Gastrointestinal Neoplasms / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D054038:Posterior Leukoencephalopathy Syndrome / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000175:diagnosis*
chemical_list: D000970:Antineoplastic Agents; D000068258:Bevacizumab; D005472:Fluorouracil
keywords: Bevacizumab; Hypertension; PRES; Seizures