title: The Caenorhabditis elegans matrix non-peptidase MNP-1 is required for neuronal cell migration and interacts with the Ror receptor tyrosine kinase CAM-1.
abstract: Directed cell migration is critical for metazoan development. During Caenorhabditis elegans development many neuronal, muscle and other cell types migrate. Multiple classes of proteins have been implicated in cell migration including secreted guidance cues, receptors for guidance cues and intracellular proteins that respond to cues to polarize cells and produce the forces that move them. In addition, cell surface and secreted proteases have been identified that may clear the migratory route and process guidance cues. We report here that mnp-1 is required for neuronal cell and growth cone migrations. MNP-1 is expressed by migrating cells and functions cell autonomously for cell migrations. We also find a genetic interaction between mnp-1 and cam-1, which encodes a Ror receptor tyrosine kinase required for some of the same cell migrations.
authors.affiliation: Medical Sciences Program, Indiana University, Bloomington, IN 47405, United States.
authors.forename: Teresa R
authors.initials: TR
authors.lastname: Craft
authors.affiliation: Medical Sciences Program, Indiana University, Bloomington, IN 47405, United States. Electronic address: wforrest@indiana.edu.
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Forrester
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology* / Q000201:enzymology*; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D019070:Cell Lineage; D002465:Cell Movement; D020439:Growth Cones / Q000378:metabolism; D009132:Muscles / Q000166:cytology; D009154:Mutation / Q000235:genetics; D009474:Neurons / Q000166:cytology* / Q000201:enzymology*; D009928:Organ Specificity; D011485:Protein Binding; D057050:Receptor Tyrosine Kinase-like Orphan Receptors / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D019076:Transgenes
chemical_list: D029742:Caenorhabditis elegans Proteins; C000619974:MNP-1 protein, C elegans; D014157:Transcription Factors; C526267:CAM-1 protein, C elegans; D057050:Receptor Tyrosine Kinase-like Orphan Receptors
keywords: Caenorhabditis elegans; Cell migration; MNP-1; Secreted peptidase