title: Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain.
abstract: Most growth factors and hormones are synthesized as pre-pro-proteins which are processed to the biologically active mature protein. The pre- and prodomains are cleaved from the precursor protein in the secretory pathway or, in some cases, extracellularly. The canonical functions of these prodomains are to assist in folding and stabilization of the mature domain, to direct intra and extracellular localization, to facilitate storage, and to regulate bioavailability of their mature counterpart. Recently, exciting evidence has revealed that prodomains of certain growth factors, after cleaved from the precursor pro-protein, can act as independent active signaling molecules. In this review, we discuss the various classical functions of prodomains, and the biological consequences of these pro-peptides acting as ligands. We will focus our attention on the brain-derived neurotrophic factor prodomain (pBDNF), which has been recently described as a novel secreted ligand influencing neuronal morphology and physiology.
authors.affiliation: Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Zanin
authors.affiliation: Instituto de Investigación Médica Mercedes y Martin Ferreyra, (INIMEC-CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Unsain
authors.affiliation: Instituto de Investigación Médica Mercedes y Martin Ferreyra, (INIMEC-CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina.
authors.forename: Agustin
authors.identifier: 0000-0001-7238-9041
authors.initials: A
authors.lastname: Anastasia
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008024:Ligands; D011498:Protein Precursors / Q000235:genetics / Q000378:metabolism*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D006728:Hormones; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D011498:Protein Precursors; C579455:BDNF protein, human
keywords: 
  pBDNF
  ; Val66Met polymorphism; active prodomains; biosynthetic pathway; precursor cleavage peptides; proBDNF