title: Diagnosis and management of lentigo maligna: an observational study comparing 2005 with 2014 data in one institution.
abstract: The incidence, clinical characteristics and management of lentigo maligna (LM) were assessed in a university hospital setting in 2005 and 2014. Multiple clinical variables were compared, and 28 and 43 cases, respectively were identified during the two time periods. The most common site of presentation was the cheek (50% vs. 44%), and an accurate clinical diagnosis of LM was made in 60% vs. 72%) of cases. Most of the patients received surgical treatment (75% in 2005 vs. 97% in 2014), with 47% and 33% of excisions, respectively, remaining involved at the peripheral surgical margin. During the 10-year follow-up for the 2005 cohort, 7 of the 28 patients had recurrence (3 of whom already had previously involved margins following surgery). This study shows that making an accurate clinical diagnosis of LM remains a significant challenge. Although surgery has become the preferred management option, achieving clear excision remains difficult, with involved margins increasing the risk of local recurrence and need for further intervention.
authors.affiliation: University of Dundee School of Medicine, Dundee, UK.
authors.forename: S
authors.initials: S
authors.lastname: Hawkey
authors.affiliation: Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK.
authors.forename: A
authors.initials: A
authors.lastname: Affleck
mesh_terms: D000328:Adult; D000634:Aminoquinolines / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D000077271:Imiquimod; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000379:methods; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D013514:Surgical Procedures, Operative; D057832:Watchful Waiting
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod