title: HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection.
abstract: Antibodies against the Human papillomavirus 16 (HPV16) E6 oncoprotein appear years prior to clinical diagnosis of anal and oropharyngeal cancer, but whether they develop around the time of HPV infection is unclear. Serum samples from 173 cancer-free men from the Human Papillomavirus Infection in Men (HIM) Study were tested for HPV antibodies and DNA. HPV16 E6 seropositivity was low among men with oral HPV16-infection (1/28; 3.6%, 95%CI=0.0%-18.4%), anal HPV16-infection (1/61; 1.6%, 95%CI=0.0%-8.8%), and 24-month persistent genital HPV16-infection (1/84; 1.2%, 0.0-6.5%). This suggests E6 seroconversion may not occur around the time of oral, anal, or genital HPV16 acquisition.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Beachler
authors.affiliation: German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Tim
authors.initials: T
authors.lastname: Waterboer
authors.affiliation: Center for Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
authors.forename: Christine M
authors.initials: ChM
authors.lastname: Pierce Campbell
authors.affiliation: Vanderbilt Institute for Global Health, Nashville, TN.
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Ingles
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
authors.forename: Krystle A Lang
authors.initials: KA
authors.lastname: Kuhs
authors.affiliation: University of Texas School of Public Health, Houston, TX.
authors.forename: Alan G
authors.initials: AG
authors.lastname: Nyitray
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
authors.forename: Allan
authors.initials: A
authors.lastname: Hildesheim
authors.affiliation: German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Pawlita
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
authors.forename: Aimée R
authors.initials: AR
authors.lastname: Kreimer
authors.affiliation: Center for Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
authors.forename: Anna R
authors.initials: AR
authors.lastname: Giuliano
keywords: HPV; HPV16 E6 seropositivity; anal cancer; oropharyngeal cancer; penile cancer