title: Acute Liver Failure During Deferasirox Chelation: A Toxicity Worth Considering.
abstract: This case report details a unique case of acute, reversible liver failure in a 12-year-old male with sickle cell anemia on chronic transfusion protocol and deferasirox chelation. There is substantial literature documenting deferasirox-induced renal injury, including Fanconi syndrome, but less documentation of hepatic toxicity and few reports of hepatic failure. The case highlights the importance of close monitoring of ferritin, bilirubin, and transaminases for patients on deferasirox.
authors.affiliation: Divisions of *Pediatric Hematology/Oncology †Genetics, Albany Medical Center ‡Department of Emergency Medicine, St Peter's Hospital, Albany, NY.
authors.forename: Nathan
authors.initials: N
authors.lastname: Menaker
authors.forename: Katharine
authors.initials: K
authors.lastname: Halligan
authors.forename: Natasha
authors.initials: N
authors.lastname: Shur
authors.forename: John
authors.initials: J
authors.lastname: Paige
authors.forename: Matthew
authors.initials: M
authors.lastname: Hickling
authors.forename: Anne
authors.initials: A
authors.lastname: Nepo
authors.forename: Lauren
authors.initials: L
authors.lastname: Weintraub
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications* / Q000628:therapy; D001565:Benzoates / Q000627:therapeutic use / Q000633:toxicity*; D001663:Bilirubin; D001803:Blood Transfusion; D002648:Child; D000077588:Deferasirox; D005293:Ferritins; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use / Q000633:toxicity; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D000637:Transaminases; D014230:Triazoles / Q000627:therapeutic use / Q000633:toxicity*
chemical_list: D001565:Benzoates; D007502:Iron Chelating Agents; D014230:Triazoles; D005293:Ferritins; D000637:Transaminases; D001663:Bilirubin; D000077588:Deferasirox