title: Absorption Profile of (Poly)Phenolic Compounds after Consumption of Three Food Supplements Containing 36 Different Fruits, Vegetables, and Berries.
abstract: The market of plant-based nutraceuticals and food supplements is continuously growing due to the increased consumer demand. The introduction of new products with relevant nutritional characteristics represents a new way of providing bioactive compounds and (poly)phenols to consumers, becoming a strategy to ideally guarantee the health benefits attributed to plant foodstuffs and allowing the increase of daily bioactive compound intake. A paramount step in the study of nutraceuticals is the evaluation of the bioavailability and metabolism of their putatively active components. Therefore, the aim of the present study was to investigate the absorption profile of the (poly)phenolic compounds contained in three different plant-based food supplements, made of 36 different plant matrices, which were consumed by 20 subjects in an open one-arm study design. Blood samples were collected at baseline and 1, 2, 5, and 10 h after capsule intake. Twenty quantifiable metabolites deriving from different (poly)phenolic compounds were identified. Results showed that the consumption of the three capsules allowed the effective absorption of several (poly)phenolic compounds and metabolites appearing at different times in plasma, thereby indicating different absorption profiles. The capsules thus ensured potential health-promoting molecules to be potentially available to target tissues and organs.
authors.affiliation: The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy. letizia.bresciani@unipr.it.
authors.forename: Letizia
authors.initials: L
authors.lastname: Bresciani
authors.affiliation: The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy. daniela.martini@unipr.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Martini
authors.affiliation: The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy. pedromiguel.menaparreno@unipr.it.
authors.forename: Pedro
authors.initials: P
authors.lastname: Mena
authors.affiliation: The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy. michele.tassotti@studenti.unipr.it.
authors.forename: Michele
authors.initials: M
authors.lastname: Tassotti
authors.affiliation: Department of Food & Drug, University of Parma, 43124 Parma, Italy. luca.calani@unipr.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Calani
authors.affiliation: The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy. giacomo.brigati@studenti.unipr.it.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Brigati
authors.affiliation: The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy. furio.brighenti@unipr.it.
authors.forename: Furio
authors.initials: F
authors.lastname: Brighenti
authors.affiliation: Institute of Pathophysiology and Immunology, Medical University of Graz, A-8010 Graz, Austria. sandra.holasek@medunigraz.at.
authors.forename: Sandra
authors.initials: S
authors.lastname: Holasek
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, Medical University of Graz, A-8010 Graz, Austria. daniela-eugenia.martin@medunigraz.at.
authors.forename: Daniela-Eugenia
authors.initials: DE
authors.lastname: Malliga
authors.affiliation: Institute of Physiological Chemistry, Medical University of Graz, A-8010 Graz, Austria. manfred.lamprecht@medunigraz.at.|Green Beat-Institute of Nutrient Research and Sport Nutrition, 8042 Graz, Austria. manfred.lamprecht@medunigraz.at.
authors.forename: Manfred
authors.initials: M
authors.lastname: Lamprecht
authors.affiliation: The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy. daniele.delrio@unipr.it.|The Need for Nutrition Education/Innovation Programme (NNEdPro), Global Centre for Nutrition and Health, St John's Innovation Centre, Cambridge CB4 0WS, UK. daniele.delrio@unipr.it.
authors.forename: Daniele
authors.initials: D
authors.lastname: Del Rio
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D002214:Capsules; D019587:Dietary Supplements; D005260:Female; D005638:Fruit; D000067030:Fruit and Vegetable Juices; D006801:Humans; D008297:Male; D028321:Plant Preparations / Q000008:administration & dosage*; D059808:Polyphenols / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014675:Vegetables; D055815:Young Adult
chemical_list: D002214:Capsules; D028321:Plant Preparations; D059808:Polyphenols
keywords: (poly)phenolic compounds; absorption; capsules; fruit and vegetables