title: Natural Products as Adjunctive Treatment for Pancreatic Cancer: Recent Trends and Advancements.
abstract: Pancreatic cancer is a type of common malignant tumors with high occurrence in the world. Most patients presented in clinic had pancreatic cancer at advanced stages. Furthermore, chemotherapy or radiotherapy had very limited success in treating pancreatic cancer. Complementary and alternative medicines, such as natural products/herbal medicines, represent exciting adjunctive therapies. In this review, we summarize the recent advances of using natural products/herbal medicines, such as Chinese herbal medicine, in combination with conventional chemotherapeutic agents to treat pancreatic cancer in preclinical and clinical trials.
authors.affiliation: Department of Oncology, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
authors.forename: Qingxi
authors.identifier: 0000-0003-4378-4012
authors.initials: Q
authors.lastname: Yue
authors.affiliation: Department of Cardiothoracic Surgery, Weihai Municipal Hospital, Weihai, Shandong, China.
authors.forename: Guogang
authors.initials: G
authors.lastname: Gao
authors.affiliation: Department of Pathology, Weihai Municipal Hospital, Weihai, Shandong, China.
authors.forename: Gangyong
authors.initials: G
authors.lastname: Zou
authors.affiliation: Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia, MO, USA.
authors.forename: Haiqing
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA; Allan H. Conney Laboratory for Anticancer Research, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
authors.forename: Xi
authors.identifier: 0000-0001-7522-631X
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001688:Biological Products / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D000093542:Gemcitabine
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D003841:Deoxycytidine; D000093542:Gemcitabine