title: The Deterioration of the Glycemic Profile during Hormone Replacement Therapy in a Patient with Fulminant Type 1 Diabetes.
abstract: Although most women with type 1 diabetes experience the normal transition to menopause, there is little information about the impact of hormone replacement therapy on their glycemic profiles. A 54-year-old postmenopausal woman with fulminant type 1 diabetes was admitted to our hospital due to diabetic ketoacidosis. She was treated with fluid replacement and a continuous insulin infusion. Thereafter, her glycemic profile was well maintained by daily multiple insulin injections. However, her glycemic profiles immediately deteriorated following the administration of progesterone in hormone replacement therapy. This transient deterioration implies that external progesterone can lead to the deterioration of glycemic profiles in postmenopausal women with type 1 diabetes.
authors.affiliation: Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Tanaka
authors.forename: Mikano
authors.initials: M
authors.lastname: Hishiki
authors.forename: Junko
authors.initials: J
authors.lastname: Ogasawara
authors.forename: Erisa
authors.initials: E
authors.lastname: Sorimachi
authors.forename: Mari
authors.initials: M
authors.lastname: Nakayama
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000209:etiology*; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008525:Medroxyprogesterone / Q000009:adverse effects; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008525:Medroxyprogesterone