title: Triple-negative breast cancer with brain metastasis in a pregnant woman.
abstract: A woman aged 35 years was diagnosed with triple-negative breast cancer in October 2012. During the investigation, it was discovered that she was pregnant, the patient decided to have an abortion. She was submitted to a radical modified mastectomy and adjuvant chemotherapy followed by adjuvant breast radiotherapy of the left breast. 2 months after the adjuvant treatment, she began to have headaches and dizziness. The cranial MRI (head MRI) showed brain metastasis. She was then treated with whole brain radiotherapy, stereotactic radiosurgery and concomitant temozolomide which resulted in complete response. 1.5 year later, she was able to get pregnant and gave birth to a baby without complications. The previous imaging reassessment performed in September 2016 shows no evidence of recurrent breast cancer.
authors.affiliation: Department of Medical Oncology, Hospital do Espírito Santo de Évora EPE, Évora, Portugal.
authors.forename: Francisco
authors.initials: F
authors.lastname: Trinca
authors.affiliation: Department of Medical Oncology, Hospital do Espírito Santo de Évora EPE, Évora, Portugal.
authors.forename: Mariana
authors.initials: M
authors.lastname: Inácio
authors.affiliation: Hospital da Luz, Lisboa, Portugal.
authors.forename: Teresa
authors.initials: T
authors.lastname: Timóteo
authors.affiliation: Department of Medical Oncology, Hospital do Espírito Santo de Évora EPE, Évora, Portugal.
authors.forename: Rui
authors.initials: R
authors.lastname: Dinis
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000556:secondary* / Q000628:therapy; D005260:Female; D005271:Femur Head Necrosis / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology* / Q000628:therapy; D064726:Triple Negative Breast Neoplasms / Q000473:pathology* / Q000628:therapy