title: Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents.
abstract: This article presents the synthesis of new derivatives of spirooxindole-spiropiperidinone- pyrrolidines6a-jand spirooxindole-spiropiperidinone-pyrrolizines8a-j,through a 1,3-dipolar cycloaddition reaction of azomethineylides generated from isatin, sarcosine, and l-proline, through a decarboxylative route with dipolarophile4a-j. All of the newly synthesized compounds were evaluated for their antimicrobial activities and their minimum inhibitory concentration (MIC) against most of the test organisms. The tested compounds displayed excellent activity against all of the tested microorganisms.
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt. huwaidahassaneen@yahoo.com.
authors.forename: Huwaida M E
authors.initials: HM
authors.lastname: Hassaneen
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt. elshimaaeid80@hotmail.com.
authors.forename: Elshimaa M
authors.initials: EM
authors.lastname: Eid
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt. profhamedead@gmail.com.
authors.forename: Hamid A
authors.initials: HA
authors.lastname: Eid
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt. thoraya-f@hotmail.com.|Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah 21514, Saudi Arabia. thoraya-f@hotmail.com.
authors.forename: Thoraya A
authors.initials: TA
authors.lastname: Farghaly
authors.affiliation: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh-11451, Saudi Arabia. yahia@ksu.edu.sa.
authors.forename: Yahia Nasser
authors.initials: YN
authors.lastname: Mabkhot
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D061565:Cycloaddition Reaction; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007211:Indoles / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D000078183:Oxindoles; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D007211:Indoles; D000078183:Oxindoles; D011759:Pyrrolidines; D013141:Spiro Compounds; C022960:2-oxindole
keywords: 1,3-dipolar cycloaddition; antimicrobial activity; azomethineylide; isatin; l-proline; sarcosine