abstract: Parkinsonian syndrome is the clinical expression of a lesion within the nigro-striatal dopaminergic pathway. Akinesia is the main manifestation of parkinsonism. The clinical analysis of motor symptoms may guide clinical diagnosis. Parkinson's disease is characterized by a pure asymmetric parkinsonian syndrome, responsive to dopaminergic treatment. The evolution of Parkinson's disease is characterized by the occurrence of motor complications (dyskinesia and fluctuations). Gait disturbances (postural instability and freezing) are late in Parkinson's disease. When early (within the first three years), they point to atypical parkinsonian syndrome.
authors.affiliation: Université de la Sorbonne, UPMC Paris 06 UMR S 1127, institut du cerveau et de la moelle, Inserm U 1127 et CIC-1422, CNRS UMR 7225, 75013 Paris, France; AP-HP, hôpital Pitié-Salpêtrière, département des maladies du système nerveux, 75013 Paris, France. Electronic address: david.grabli@psl.aphp.fr.
authors.forename: David
authors.initials: D
authors.lastname: Grabli
mesh_terms: D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D001184:Articulation Disorders / Q000209:etiology / Q000503:physiopathology; D003342:Corpus Striatum / Q000503:physiopathology; D003680:Deglutition Disorders / Q000209:etiology / Q000503:physiopathology; D018450:Disease Progression; D018491:Dopamine Agonists / Q000009:adverse effects / Q000627:therapeutic use; D059290:Dopaminergic Neurons / Q000473:pathology / Q000502:physiology; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D018476:Hypokinesia / Q000209:etiology / Q000503:physiopathology; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D009068:Movement / Q000502:physiology; D009122:Muscle Hypertonia / Q000209:etiology / Q000503:physiopathology; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D020734:Parkinsonian Disorders / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D004856:Postural Balance; D012678:Sensation Disorders / Q000209:etiology / Q000503:physiopathology; D013378:Substantia Nigra / Q000503:physiopathology; D014202:Tremor / Q000209:etiology / Q000503:physiopathology
chemical_list: D000978:Antiparkinson Agents; D018491:Dopamine Agonists; D007980:Levodopa