title: Successful infliximab therapy in a patient with comorbid spondyloarthritis, primary biliary cirrhosis and generalized morphea.
abstract: The patient in this report was diagnosed simultaneously with primary biliary cirrhosis (PBC), spondyloarthritis, and generalized morphea and was started on infliximab therapy. In addition to an improvement in clinical symptoms with this therapy, an improvement was also observed in laboratory parameters such as cholestatic enzymes, C-reactive protein, and erythrocyte sedimentation rate. Infliximab was well tolerated in this 56-year-old patient. However, further studies must be performed in order to clarify the therapeutic role of TNF-α blockers in, PBC and generalized morphea.
authors.affiliation: a Faculty of Medicine, Department of Physical Medicine and Rehabilitation , Canakkale Onsekiz Mart University , Canakkale , Turkey.
authors.forename: Hatice
authors.identifier: http://orcid.org/0000-0001-9889-1064
authors.initials: H
authors.lastname: Resorlu
authors.affiliation: b Faculty of Medicine, Department of Dermatology , Canakkale Onsekiz Mart University , Canakkale , Turkey.
authors.forename: Sevilay
authors.initials: S
authors.lastname: Kılıc
authors.affiliation: b Faculty of Medicine, Department of Dermatology , Canakkale Onsekiz Mart University , Canakkale , Turkey.
authors.forename: Selda
authors.initials: S
authors.lastname: Isık
authors.affiliation: a Faculty of Medicine, Department of Physical Medicine and Rehabilitation , Canakkale Onsekiz Mart University , Canakkale , Turkey.
authors.forename: Ferhat
authors.initials: F
authors.lastname: Gokmen
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000069285:Infliximab / Q000627:therapeutic use*; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000150:complications* / Q000188:drug therapy; D025241:Spondylarthritis / Q000150:complications* / Q000188:drug therapy
chemical_list: D018501:Antirheumatic Agents; D000069285:Infliximab
keywords: Generalized morphea; Infliximab; Primary biliary cirrhosis; Spondyloarthritis