title: [Prospects for using biological markers in various types of urinary stone lithotripsy].
abstract: OBJECTIVE
  To investigate the feasibility of using biological markers for determining the optimal timing to repeat lithotripsy of urinary stones.
  
  
  METHODS
  This was a prospective, randomized, single-center cohort study of 100 patients randomized into 4 groups. Patients of group I (n=46), II (n=20), III (n=18) and IV (n=16) were used contact lithotripsy (URS), ESWL, PNL, combined lithotripsy. In all patients, before surgery and at 1, 7, 14, 20 days after lithotripsy, iron-induced urine chemiluminescence was measured to determine the level of reactive oxygen species (ROS) and concentration of medium-mass molecules (MMM) in urine.
  
  
  RESULTS
  Analyzing the time of operation and the size of stones only in group I was detected the significant negative correlation (r=-0,479, p<0,05). In patients of all groups, the level of ROS have decreased after the surgery with further returning to baseline level. Dynamics of changes MMM in urine has not revealed a reliable change tendency.
  
  
  CONCLUSIONS
  The definition of the quantity of ROS in urine is a promising criterion in measuring the degree of urinary system damage and the time for repeated lithotripsy. The level of ROS in the urine after URS, ESWL and the ESWL-URS combination returns to baseline on the 7th day and after PNL on the 14th day postoperatively, thus allowing to pathogenetically define the optimal timing of repeat lithotripsy.
authors.affiliation: Multidisciplinary Medical Medical Clinic Medservice, Department of Urology, Salavat.
authors.forename: M M
authors.initials: MM
authors.lastname: Kutluev
authors.affiliation: Multidisciplinary Medical Medical Clinic Medservice, Department of Urology, Salavat.
authors.forename: I L
authors.initials: IL
authors.lastname: Pulin
authors.affiliation: Multidisciplinary Medical Medical Clinic Medservice, Department of Urology, Salavat.
authors.forename: A Ya
authors.initials: AY
authors.lastname: Ryakhov
authors.affiliation: Bashkir State Medical University, Central Medical and Scientists Laboratory, Ufa.
authors.forename: K S
authors.initials: KS
authors.lastname: Mochalov
authors.affiliation: Bashkir State Medical University, Central Medical and Scientists Laboratory, Ufa.
authors.forename: R R
authors.initials: RR
authors.lastname: Farkhutdinov
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D005260:Female; D006801:Humans; D008096:Lithotripsy / Q000379:methods*; D008163:Luminescent Measurements / Q000379:methods; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017382:Reactive Oxygen Species / Q000652:urine*; D016896:Treatment Outcome; D014545:Urinary Calculi / Q000628:therapy / Q000652:urine; D052878:Urolithiasis / Q000628:therapy* / Q000652:urine*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species
keywords: biological markers; lithotripsy; medium-mass molecules; reactive oxygen species; urolithiasis