title: Recombinant Newcastle disease virus expressing human TRAIL as a potential candidate for hepatoma therapy.
abstract: Newcastle disease virus (NDV) have shown oncolytic therapeutic efficacy in preclinical studies and are currently proved for clinical trials. We have previously reported, for the first time, NDV Anhinga strain has an efficient cancer therapeutic efficacy in hepatoma. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) functions as a cytokine to selectively kill various cancer cells without toxicity to most normal cells. Numerous studies have demonstrated the potential use of recombinant soluble TRAIL as a cancer therapeutic agent. In this study, we have showed administration of a recombinant NDV Anhinga strain expressing soluble TRAIL (NDV/Anh-TRAIL) results in an efficient suppression of hepatocellular carcinoma without significant toxicity. The results show that recombinant NDV Anhinga strain expressing soluble TRAIL is a promising candidate for hepatoma therapy.
authors.affiliation: College of Life Science, Northeast Agriculture University, Mucai Street 59, Xiangfang District, Harbin, China.
authors.forename: Yunzhou
authors.initials: Y
authors.lastname: Wu
authors.affiliation: College of life science and technology, Xinxiang University, Jinsui Avenue, Hongqi District, Xinxiang, China.
authors.forename: Jinjiao
authors.initials: J
authors.lastname: He
authors.affiliation: The Pathology Department, Affiliated Tumor Hospital of Harbin Medical University, Yiyuan Street 37, Nangang District, Harbin, China.
authors.forename: Jingshu
authors.initials: J
authors.lastname: Geng
authors.affiliation: College of Life Science, Northeast Agriculture University, Mucai Street 59, Xiangfang District, Harbin, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: An
authors.affiliation: School of Life Science, Henan Normal University, 46 Jianshe Road E., Xinxiang, China.
authors.forename: Xianlong
authors.initials: X
authors.lastname: Ye
authors.affiliation: College of Life Science, Northeast Agriculture University, Mucai Street 59, Xiangfang District, Harbin, China.
authors.forename: Shijun
authors.initials: S
authors.lastname: Yan
authors.affiliation: Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA.
authors.forename: Qingzhong
authors.initials: Q
authors.lastname: Yu
authors.affiliation: College of Life Science, Northeast Agriculture University, Mucai Street 59, Xiangfang District, Harbin, China.
authors.forename: Jiechao
authors.initials: J
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: College of Life Science, Northeast Agriculture University, Mucai Street 59, Xiangfang District, Harbin, China.
authors.forename: Deshan
authors.initials: D
authors.lastname: Li
mesh_terms: D000818:Animals; D017209:Apoptosis; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D053148:Caspase 3 / Q000235:genetics; D049109:Cell Proliferation; D004274:DNA, Recombinant / Q000235:genetics*; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008813:Mice, Inbred ICR; D009522:Newcastle disease virus / Q000235:genetics* / Q000502:physiology*; D050130:Oncolytic Virotherapy / Q000379:methods*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics*; D014779:Virus Replication
chemical_list: D004274:DNA, Recombinant; D012333:RNA, Messenger; D053221:TNF-Related Apoptosis-Inducing Ligand; D053148:Caspase 3
keywords: Hepatocellular carcinoma; Hepatoma; Newcastle disease virus; Oncolysis; TRAIL