title: [A clinical study of serum protein markers in patients with 1-bromopropane poisoning].
abstract: Objective:To investigate the changes in protein expression in patients with 1-bromopropane (1-BP) poisoning using high-throughput proteomic technique and to screen out protein markers.Methods:Serum samples were collected from 3 patients with 1-BP poisoning and 15 controls. The label-free proteomic tech-nique was used for the quantitation and identification of proteins expressed in these samples, and the results were compared between the patients with 1-BP poisoning and the control population. The bioinformatics tools were used to analyze the function of differentially expressed proteins.Results:Compared with the control popula-tion, the patients with 1-BP poisoning had >2-fold upregulation of 38 proteins and >2-fold downregulation of 68 proteins. The differentially expressed proteins were mainly involved in immune response, signal transduction, and stress response.Conclusion:The proteins screened out may be potential protein markers for 1-BP poison-ing, which provides reliable and precise methods and thoughts for the diagnosis of 1-BP poisoning.
authors.affiliation: Wuxi NO.8 People's Hospital (Wuxi Hospital for Prevention and Treatment of Occupational Disease) , Wuxi 214011, China.
authors.forename: R M
authors.initials: RM
authors.lastname: Miao
authors.forename: B
authors.initials: B
authors.lastname: Cao
authors.forename: Y M
authors.initials: YM
authors.lastname: Yao
authors.forename: Y Y
authors.initials: YY
authors.lastname: Zhang
authors.forename: W M
authors.initials: WM
authors.lastname: Wu
authors.forename: Z H
authors.initials: ZH
authors.lastname: Fang
authors.forename: R
authors.initials: R
authors.lastname: Zhao
authors.forename: C
authors.initials: C
authors.lastname: Luo
authors.forename: B L
authors.initials: BL
authors.lastname: Zhu
mesh_terms: D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins; D016022:Case-Control Studies; D020869:Gene Expression Profiling; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000506:poisoning; D011041:Poisoning; D020543:Proteome; D040901:Proteomics
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D006842:Hydrocarbons, Brominated; D020543:Proteome; C118559:1-bromopropane
keywords: 1-Bromopropane; Poisoning; Protein