title: Hydroxyapatite nanorod-assembled porous hollow polyhedra as drug/protein carriers.
abstract: Hydroxyapatite (HAP) with a porous hollow structure is an ideal biomaterial owing to its excellent biocompatibility and unique architecture. In this study, HAP nanorod-assembled porous hollow polyhedra, consisting of nanorod building blocks, have been successfully prepared at room temperature or under hydrothermal circumstances using a self-sacrificing Ca(OH)2template strategy. The hydrothermal treatment (at 180°C for 1h) can promote the HAP nanorods to be arranged with their axial direction normal to the polyhedron surface. The HAP nanorod-assembled porous hollow polyhedra have been explored for the potential application in drug/protein delivery, using ibuprofen (IBU) as a model drug and hemoglobin (Hb) as a model protein. The experimental results indicate that the HAP nanorod-assembled porous hollow polyhedra have a relatively high drug loading capacity and protein adsorption ability, and sustained drug and protein release. The HAP nanorod-assembled porous hollow polyhedra have promising applications in various biomedical fields such as the drug and protein delivery.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Ya-Dong
authors.initials: YD
authors.lastname: Yu
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address: y.j.zhu@mail.sic.ac.cn.
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Qi
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Heng
authors.initials: H
authors.lastname: Li
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. Electronic address: wujin@mail.sic.ac.cn.
authors.forename: Jin
authors.initials: J
authors.lastname: Wu
mesh_terms: D000327:Adsorption; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D017886:Durapatite / Q000737:chemistry*; D006454:Hemoglobins / Q000008:administration & dosage / Q000737:chemistry; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry*; D016062:Porosity
chemical_list: D004337:Drug Carriers; D006454:Hemoglobins; D017886:Durapatite; D007052:Ibuprofen
keywords: Biomaterials; Drug delivery; Hydrothermal; Hydroxyapatite; Protein adsorption