title: Copper-catalyzed aerobic oxidative coupling of o-phenylenediamines with 2-aryl/heteroarylethylamines: direct access to construct quinoxalines.
abstract: A copper-catalyzed oxidative coupling reaction of o-phenylenediamines with 2-aryl/heteroarylethylamines using molecular oxygen as an oxidant has been developed. This approach provides a practical and direct access to construct quinoxalines in excellent yields at room temperature. The reaction has a broad substrate scope and exhibits excellent functional-group tolerance. This method could be easily scaled up and applied to the synthesis of biologically active molecules bearing a quinoxaline structural scaffold.
authors.affiliation: Organic Synthesis and Catalysis Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India. gopal@chemistry.du.ac.in.
authors.forename: Kovuru
authors.identifier: http://orcid.org/0000-0002-6233-2209
authors.initials: K
authors.lastname: Gopalaiah
authors.affiliation: Organic Synthesis and Catalysis Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India. gopal@chemistry.du.ac.in.
authors.forename: Anupama
authors.initials: A
authors.lastname: Saini
authors.affiliation: Organic Synthesis and Catalysis Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India. gopal@chemistry.du.ac.in.
authors.forename: Sankala Naga
authors.initials: SN
authors.lastname: Chandrudu
authors.affiliation: Organic Synthesis and Catalysis Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India. gopal@chemistry.du.ac.in.
authors.forename: Devarapalli Chenna
authors.initials: DC
authors.lastname: Rao
authors.affiliation: Crystal Lab, Department of Physics & Astrophysics, University of Delhi, Delhi 110007, India.
authors.forename: Harsh
authors.initials: H
authors.lastname: Yadav
authors.affiliation: Crystal Lab, Department of Physics & Astrophysics, University of Delhi, Delhi 110007, India.
authors.forename: Binay
authors.initials: B
authors.lastname: Kumar