title: Italian guidelines on the systemic treatments of moderate-to-severe plaque psoriasis.
abstract: Psoriasis is a common disease, which has a considerable impact on the healthcare system. Therefore, appropriate use of therapeutic resources is very important. Management of psoriasis in daily clinical practice is highly variable because many issues are still debated and not definitely addressed by the evidence-based medicine. Moreover, the different availability and reimbursability of drugs in each country justifies national guidelines. Expert consensus can provide helpful guidelines for optimizing patient care. A total of 20 dermatologists from different areas of Italy and with large experience in the treatment of psoriasis agreed to participate in the guidelines expert panel who aimed to reach consensus on the factors influencing psoriasis severity, the indications for systemic treatments, the parameters to be considered in the choice of treatment, and the factors to be considered in the choice of biological treatment. The recommendations for the use, screening and monitoring of systemic therapies were based on the 2015 S3 European Dermatology Forum/European Academy of Dermatology and Venereology psoriasis guidelines. Recommendations on the treatment of psoriasis in special patient populations were also agreed. The final document was discussed in a meeting moderated by a facilitator with participation of the entire group and adopting a nominal group technique to reach consensus. A statement was regarded as consented when agreement was achieved by at least 75% of the voting experts according to the Delphi procedure.
authors.affiliation: Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Gisondi
authors.affiliation: Department of Dermatology and Venereology, I.R.C.C.S. Istituto Ortopedico Galeazzi, University of Milan, Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Altomare
authors.affiliation: Department of Dermatology, University of Naples Federico II, Napoli, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ayala
authors.affiliation: Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bardazzi
authors.affiliation: Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bianchi
authors.affiliation: Department of Dermatology, University of Pisa, Pisa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Chiricozzi
authors.affiliation: Department of Dermatology, Humanitas Research Hospital, Rozzano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Costanzo
authors.affiliation: Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Conti
authors.affiliation: Department of Biomedical Science and Human Oncology, Second Dermatologic Clinic, University of Turin, Turin, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Dapavo
authors.affiliation: Department of Dermatology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: De Simone
authors.affiliation: Department of Biomedical Science and Human Oncology, Section of Dermatology, University of Bari, Bari, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Foti
authors.affiliation: Department of Dermatology, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Naldi
authors.affiliation: Department of Clinical and Molecular Sciences, Dermatology Unit, Polytechnic Marche University, Ancona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Offidani
authors.affiliation: Department of Dermatology, University of Genoa, Genova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Parodi
authors.affiliation: Department of Dermatology, University of Padua, Padova, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Piaserico
authors.affiliation: Department of Dermatology, University of Florence, Firenze, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Prignano
authors.affiliation: Department of Medical Sciences and Public Health, Section of Dermatology, University of Cagliari, Cagliari, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Rongioletti
authors.affiliation: Department of Medicine, Section of Clinical, Allergological and Venereological Dermatology, University of Perugia, Perugia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Stingeni
authors.affiliation: Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Talamonti
authors.affiliation: Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Girolomoni
mesh_terms: D019317:Evidence-Based Medicine; D006801:Humans; D007558:Italy; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index