title: Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis.
abstract: METHODS
  BALB/c (WT) and BALB/c (IL-4-KO) mice were inoculated intracranially with Taenia crassiceps cysticerci and euthanized at 7, 30, 60 and 90 days later, the encephala removed and histopathologically analyzed.
  
  
  RESULTS
  The absence of IL-4 induced greater parasitism. In the initial phase of the infection, IL-4-KO showed a lower intensity in the inflammatory infiltration of polimorphonuclear cells in the host-parasite interface and intra-parenquimatous edema. The IL-4-KO animals, in the late phase of the infection, showed lower intensity of ventriculomegaly, encephalitis, and meningitis, and greater survival of the parasites in comparison with the WT animals.
  
  
  CONCLUSIONS
  The absence of IL-4 induced lower inflammatory infiltration, ventriculomegaly and perivasculitis in experimental NCC.
authors.affiliation: Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia GO, Brasil.|Centro Universitário UNIRG, Faculdade de Medicina, Gurupi TO, Brasil.
authors.forename: Hidelberto Matos
authors.initials: HM
authors.lastname: Silva
authors.affiliation: Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia GO, Brasil.
authors.forename: Marina Clare
authors.initials: MC
authors.lastname: Vinaud
authors.affiliation: Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia GO, Brasil.
authors.forename: Ruy de Souza
authors.initials: RS
authors.lastname: Lino
mesh_terms: D000818:Animals; D001921:Brain / Q000469:parasitology*; D003552:Cysticercus / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D006790:Host-Parasite Interactions; D000069544:Infectious Encephalitis / Q000097:blood / Q000469:parasitology*; D015847:Interleukin-4 / Q000097:blood*; D051379:Mice; D008807:Mice, Inbred BALB C; D020019:Neurocysticercosis / Q000097:blood / Q000469:parasitology*; D013997:Time Factors
chemical_list: D015847:Interleukin-4