title: Responsiveness to bronchodilator procaterol in COPD as assessed by forced oscillation technique.
abstract: The aim of this retrospective study was to assess responses to a bronchodilator by forced oscillation technique (FOT) and to relate the results of respiratory impedance (Zrs) to spirometric parameters in patients with chronic obstructive pulmonary disease (COPD). Zrs was measured as a function of frequency from 4 to 36Hz before and after inhalation of procaterol, a short-acting β2-agonist (n=60). Respiratory resistance (Rrs) and reactance (Xrs) were significantly frequency-dependent, and inspiratory and expiratory phases were different both before and after procaterol inhalation. The Rrs at 4Hz and Xrs at 4-20Hz during a whole breath were significantly improved after procaterol inhalation. The response to procaterol inhalation varied among patients, and changes in Xrs at 4Hz significantly correlated with% change in forced expiratory volume in one second and changes in forced vital capacity. Taken together, Zrs, and specifically Xrs parameters, are sensitive to acute physiological responses to a bronchodilator in COPD.
authors.affiliation: Department of Respiratory Medicine, Nagoya University School of Medicine, Nagoya 466-8550, Japan. Electronic address: itori@med.nagoya-u.ac.jp.
authors.forename: Satoru
authors.initials: S
authors.lastname: Ito
authors.affiliation: Clinical Laboratory, Nagoya University Hospital, Nagoya 466-8550, Japan.
authors.forename: Akemi
authors.initials: A
authors.lastname: Uchida
authors.affiliation: Department of Respiratory Medicine, Nagoya University School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Isobe
authors.affiliation: Department of Respiratory Medicine, Nagoya University School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hasegawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000403:Airway Resistance / Q000187:drug effects; D000704:Analysis of Variance; D001993:Bronchodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009991:Oscillometry; D017265:Procaterol / Q000494:pharmacology* / Q000627:therapeutic use; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D013147:Spirometry; D013990:Tidal Volume / Q000187:drug effects
chemical_list: D001993:Bronchodilator Agents; D017265:Procaterol
keywords: Airway; Airway smooth muscle; Bronchodilator; Forced oscillation technique; Impedance; Procaterol