title: Interaction of endothelial cells with macrophages-linking molecular and metabolic signaling.
abstract: Angiogenesis and inflammation go hand in hand in various (patho-)physiological conditions. Several studies have highlighted the interconnection between endothelial cells (ECs) and macrophages in these conditions at the level of growth factor and cytokine signaling, yet the importance of metabolism and metabolic signaling has been largely overlooked. Modulating macrophage and/or endothelial functions by interfering with metabolic pathways offers new perspectives for therapeutic strategies. In this review, we highlight the complexity of the interrelationship between the inflammatory response and angiogenesis. More in particular, the interaction between macrophages and ECs will be discussed with a special focus on how their metabolism can contribute to (patho-)physiological conditions.
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, VIB, Campus Gasthuisberg O&N4, Herestraat 49-912, Leuven, 3000, Belgium. joanna.kalucka@kuleuven.vib.be.|Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Campus Gasthuisberg O&N4, Leuven, 3000, Belgium. joanna.kalucka@kuleuven.vib.be.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kalucka
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, VIB, Campus Gasthuisberg O&N4, Herestraat 49-912, Leuven, 3000, Belgium.|Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Campus Gasthuisberg O&N4, Leuven, 3000, Belgium.
authors.forename: Laura
authors.initials: L
authors.lastname: Bierhansl
authors.affiliation: Department of Clinical Pathobiochemistry, Faculty of medicine, Institute of Clinical Chemistry and Laboratory Medicine, Dresden, Germany.
authors.forename: Ben
authors.initials: B
authors.lastname: Wielockx
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, VIB, Campus Gasthuisberg O&N4, Herestraat 49-912, Leuven, 3000, Belgium.|Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Campus Gasthuisberg O&N4, Leuven, 3000, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Carmeliet
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, VIB, Campus Gasthuisberg O&N4, Herestraat 49-912, Leuven, 3000, Belgium. guy.eelen@kuleuven.vib.be.|Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Campus Gasthuisberg O&N4, Leuven, 3000, Belgium. guy.eelen@kuleuven.vib.be.
authors.forename: Guy
authors.initials: G
authors.lastname: Eelen
mesh_terms: D000818:Animals; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008264:Macrophages / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
keywords: Angiogenesis; Cell metabolism; Endothelial cells; Inflammation; Macrophages