title: Of fish and mirrors: Fluoxetine disrupts aggression and learning for social rewards.
abstract: Aggressive signaling is a key social behavior of male Siamese fighting fish (Betta splendens). Successfully establishing a territory and defending it from intruders has direct fitness effects, making Betta splendens a prime model for studies examining the biological underpinnings of aggressive behavior. Current research has outlined serotonin transporter pathways as one key component for the engagement and coordination of aggressive behavior in Betta splendens. Using the selective serotonin reuptake inhibitor fluoxetine, we examined the impact of 10μmol exposures on associative learning and aggression between mirror and conspecific social reinforcers. Our results provide clear evidence that exposure to fluoxetine reduces aggression and impairs learning independent of social reinforce type. In addition, our results provide support for motor inhibition of aggressive behavior as the main behavioral mechanism of action for fluoxetine. Placed within the broader context of behavioral syndromes, our results, along with others, implicate serotonergic pathways as a key biological correlate of the bold-aggressive phenotype.
authors.affiliation: Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14628, United States. Electronic address: benjaminr.eisenreich@gmail.com.
authors.forename: Benjamin R
authors.initials: BR
authors.lastname: Eisenreich
authors.affiliation: Department of Psychology, University of Montana, Missoula, MT 59812, United States.
authors.forename: Susan
authors.initials: S
authors.lastname: Greene
authors.affiliation: Department of Psychology, University of Montana, Missoula, MT 59812, United States.
authors.forename: Allen
authors.initials: A
authors.lastname: Szalda-Petree
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001245:Association Learning / Q000187:drug effects*; D003657:Decision Making / Q000187:drug effects; D005399:Fishes; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D011930:Reaction Time / Q000187:drug effects; D012201:Reward; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012919:Social Behavior
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Aggression; Betta splendens; Fluoxetine; Serotonin; Social reinforcement