title: Whole-Genome Sequencing in Epidemiology of Campylobacter jejuni Infections.
abstract: This review describes the current state of knowledge regarding the application of whole-genome sequencing (WGS) in the epidemiology ofCampylobacter jejuni, the leading cause of bacterial gastroenteritis worldwide. We describe how WGS has increased our understanding of the evolutionary and epidemiological dynamics of this pathogen and how WGS has the potential to improve surveillance and outbreak detection. We have identified hurdles to the full implementation of WGS in public health settings. Despite these challenges, we think that ample evidence is available to support the benefits of integrating WGS into the routine monitoring ofC. jejuniinfections and outbreak investigations.
authors.affiliation: Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
authors.forename: Ann-Katrin
authors.initials: AK
authors.lastname: Llarena
authors.affiliation: National Microbiology Laboratory at Lethbridge, Animal Diseases Research Institute, Public Health Agency of Canada, Lethbridge, Alberta, Canada.
authors.forename: Eduardo
authors.identifier: 0000-0001-8373-3653
authors.initials: E
authors.lastname: Taboada
authors.affiliation: Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland mirko.rossi@helsinki.fi.
authors.forename: Mirko
authors.initials: M
authors.lastname: Rossi
mesh_terms: D002169:Campylobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D016123:Campylobacter jejuni / Q000235:genetics*; D004196:Disease Outbreaks; D005517:Foodborne Diseases / Q000453:epidemiology* / Q000382:microbiology; D005759:Gastroenteritis / Q000453:epidemiology* / Q000382:microbiology; D014644:Genetic Variation / Q000235:genetics; D016680:Genome, Bacterial / Q000235:genetics*; D006801:Humans; D017720:Molecular Epidemiology / Q000379:methods*; D058889:Molecular Typing
keywords: foodborne pathogens; genome analysis; molecular subtyping; surveillance studies