title: Second re-irradiation for DIPG progression, re-considering "old strategies" with new approaches.
abstract: Diffuse intrinsic pontine glioma (DIPG) is an aggressive infiltrative glioma for which no curative therapy is available. Radiation therapy (RT) is the only potentially effective intervention in delaying tumor progression, but only transiently. At progression, re-irradiation is gaining popularity as an effective palliative therapy. However, at second progression, exclusive symptomatic treatment is usually offered. Here we report two patients with DIPG at second progression who were treated with a second re-irradiation course with good response. Importantly, treatment was well tolerated with no irradiation associated acute toxicity identified.
authors.affiliation: Pediatric Neuro-Oncology, Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Passeig Sant Joan de Déu 2, 08950, Barcelona, Spain. amorales@hsjdbcn.org.|Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Spain. amorales@hsjdbcn.org.
authors.forename: Andres
authors.initials: A
authors.lastname: Morales La Madrid
authors.affiliation: Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Santa-María
authors.affiliation: Pediatric Neuro-Oncology, Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Passeig Sant Joan de Déu 2, 08950, Barcelona, Spain.|Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.
authors.forename: Ofelia
authors.initials: O
authors.lastname: Cruz Martinez
authors.affiliation: Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Mora
authors.affiliation: Pediatric Neurosurgery, Hospital Sant Joan de Déu, Barcelona, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Puerta Roldan
authors.affiliation: Pediatric Neurosurgery, Hospital Sant Joan de Déu, Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Guillen Quesada
authors.affiliation: Department of Pathology, Hospital Sant Joan de Déu, Barcelona, Spain.
authors.forename: Mariona
authors.initials: M
authors.lastname: Suñol Capella
authors.affiliation: Developmental Tumor Biology Laboratory, Institut de Recerca Pediàtrica-Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: de Torres Gomez-Pallete
authors.affiliation: Neuro-Oncology Department, Division of Pediatric Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Lassaletta
authors.affiliation: Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Canada.
authors.forename: Normand
authors.initials: N
authors.lastname: Laperriere
authors.affiliation: Department of Radiation Oncology, Institut Oncològic Teknon and Institut Català d'Oncologia, Barcelona, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Villà
authors.affiliation: Neuro-Oncology Department, Division of Pediatric Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Bouffet
mesh_terms: D020295:Brain Stem Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D000069475:Re-Irradiation / Q000379:methods*
keywords: DIPG; Second re-irradiation