title: Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice.
abstract: Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia. mgruden@mail.ru.
authors.forename: M A
authors.initials: MA
authors.lastname: Gruden
authors.affiliation: Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Davydova
authors.affiliation: Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Fomina
authors.affiliation: Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Vetrile
authors.affiliation: Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden.
authors.forename: L A
authors.initials: LA
authors.lastname: Morozova-Roche
authors.affiliation: Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10, 3NB, UK.
authors.forename: R D E
authors.initials: RD
authors.lastname: Sewell
mesh_terms: D000375:Aging / Q000502:physiology*; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D058227:Amyloidogenic Proteins / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000302:isolation & purification / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D040502:Calgranulin B / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000302:isolation & purification / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D065852:Spatial Memory / Q000187:drug effects* / Q000502:physiology
chemical_list: D058227:Amyloidogenic Proteins; D000906:Antibodies; D040502:Calgranulin B; D018691:Excitatory Amino Acid Antagonists; D018698:Glutamic Acid
keywords: S100A9 fibrils; amnesia; antibodies to glutamate; locomotor activity; spatial memory