title: Tetrabromobisphenol A (TBBPA) exhibits specific antimicrobial activity against Gram-positive bacteria without detectable resistance.
abstract: We report here the antimicrobial ability of tetrabromobisphenol A (TBBPA) against Gram-positive bacteria without detectable resistance. Microscopy imaging and gene analysis reveal that the bacterial cell wall is the target of TBBPA. Structure-activity studies of TBBPA and its analogues relate the observed antimicrobial activity to the halogen substitution neighboring the phenolic hydroxyl group.
authors.affiliation: School of Medicine, Jianghan University, Wuhan 430056, P. R. China. ly76@263.net.
authors.forename: Fang
authors.initials: F
authors.lastname: Ji
authors.affiliation: Institute of Environment and Health, Jianghan University, Wuhan 430056, P. R. China.
authors.forename: Chang
authors.initials: C
authors.lastname: Wang
authors.affiliation: Institute of Environment and Health, Jianghan University, Wuhan 430056, P. R. China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Wang
authors.affiliation: Institute of Environment and Health, Jianghan University, Wuhan 430056, P. R. China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Institute for Interdisciplinary Research, Jianghan University, Wuhan 430056, P. R. China.
authors.forename: Bolei
authors.initials: B
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Beijing 100085, P. R. China.
authors.forename: Ligang
authors.identifier: http://orcid.org/0000-0002-6213-4720
authors.initials: L
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Beijing 100085, P. R. China.
authors.forename: Guibin
authors.initials: G
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Beijing 100085, P. R. China.
authors.forename: Maoyong
authors.initials: M
authors.lastname: Song
authors.affiliation: School of Medicine, Jianghan University, Wuhan 430056, P. R. China. ly76@263.net and Institute of Environment and Health, Jianghan University, Wuhan 430056, P. R. China and Key Laboratory of Optoelectronic Chemical Materials and Devices (Jianghan University), Ministry of Education, Wuhan 430056, P. R. China.
authors.forename: Yong
authors.identifier: http://orcid.org/0000-0003-2212-6694
authors.initials: Y
authors.lastname: Liang
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011075:Polybrominated Biphenyls / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D011075:Polybrominated Biphenyls; C020806:tetrabromobisphenol A