title: Spectroscopic Photoacoustic Imaging of Gold Nanorods.
abstract: Photoacoustic imaging is a rapidly developing tool capable of achieving high-resolution images with optical contrast at imaging depths up to a few centimeters. When combined with targeted nanoparticle contrast agents, sensitive detection of molecular signatures is possible. In this chapter, we discuss the achievements and future directions of nanoparticle-augmented photoacoustic imaging. We present a method to synthesize silica-coated gold nanorods, which are highly stable, signal amplifying photoacoustic contrast agents, and also describe spectroscopic image acquisition and processing steps to provide a specific map of nanoparticle distribution in vivo.
authors.affiliation: Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH, 03755, USA.
authors.forename: Austin Van
authors.initials: AV
authors.lastname: Namen
authors.affiliation: Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH, 03755, USA. Geoffrey.P.Luke@dartmouth.edu.
authors.forename: Geoffrey P
authors.initials: GP
authors.lastname: Luke
mesh_terms: D003287:Contrast Media / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D007091:Image Processing, Computer-Assisted; D057054:Molecular Imaging / Q000379:methods*; D043942:Nanotubes / Q000737:chemistry / Q000648:ultrastructure; D061088:Photoacoustic Techniques / Q000379:methods*; D011092:Polyethylene Glycols; D012822:Silicon Dioxide / Q000737:chemistry; D013057:Spectrum Analysis / Q000379:methods*; D013223:Statistics as Topic
chemical_list: D003287:Contrast Media; D011092:Polyethylene Glycols; D006046:Gold; D012822:Silicon Dioxide
keywords: Gold nanorods; Molecular imaging; Photoacoustic imaging; Spectroscopy