title: Inhibitory control in euthymic bipolar disorder: Event related potentials during a Go/NoGo task.
abstract: Patients with bipolar disorder (BD) are reported to have difficulties with inhibition, even in a euthymic state. However, the literature on cortical activity associated with response inhibition in BD remains ambiguous. This study investigates inhibition in euthymic BD using electrophysiological measures, while controlling for effects of specific medications.
  
  
  
  Twenty patients with BD were compared with eighteen healthy controls on a Go/NoGo task while electroencephalogram was recorded. Behavioral and event-related potential (ERP) measurements were analyzed for the two groups. Medication effects were controlled for in the analysis.
  
  
  
  Patients with BD had marginally reduced NoGo N2 amplitudes and increased NoGo P3 amplitudes compared with healthy controls when patients using benzodiazepines were excluded from the study. No behavioral differences between the groups were found.
  
  
  
  Reduced NoGo N2 amplitudes in BD reflect aberrant conflict detection, an early stage of the inhibition process. In addition, increased NoGo P3 amplitudes in BD despite normal task performance reflect an overactive cortical system during a simple inhibition task.
  
  
  
  Difficulties in early stages of inhibition in BD appear to have been compensated by increased cortical activation. This study extends current knowledge regarding cortical activations relating to inhibition in BD.
authors.affiliation: Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium. Electronic address: anne.morsel@uantwerpen.be.
authors.forename: A M
authors.initials: AM
authors.lastname: Morsel
authors.affiliation: Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium; Biological Psychology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Dhar
authors.affiliation: Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium; Nijmegen Institute for Cognition and Information (NICI), Radboud University of Nijmegen, P.O. Box 9104, 6500 HE Nijmegen, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Hulstijn
authors.affiliation: Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Temmerman
authors.affiliation: Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium; Psychiatric Hospital Brothers Alexians, Provinciesteenweg 408, B-2530 Boechout, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Morrens
authors.affiliation: Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium; Psychiatric Hospital St Norbertus, Stationsstraat 22c, B-2570 Duffel, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Sabbe
mesh_terms: D000328:Adult; D001288:Attention; D001714:Bipolar Disorder / Q000503:physiopathology*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition
keywords: Bipolar disorder; Event related potentials; Inhibition; NoGo; P3