title: Early Diagnosis and Prediction of Anticancer Drug-induced Cardiotoxicity: From Cardiac Imaging to "Omics" Technologies.
abstract: Heart failure due to antineoplastic therapy remains a major cause of morbidity and mortality in oncological patients. These patients often have no prior manifestation of disease. There is therefore a need for accurate identification of individuals at risk of such events before the appearance of clinical manifestations. The present article aims to provide an overview of cardiac imaging as well as new "-omics" technologies, especially with regard to genomics and proteomics as promising tools for the early detection and prediction of cardiotoxicity and individual responses to antineoplastic drugs.
authors.affiliation: Center for Aging Sciences and Translational Medicine (CeSI-MeT), "G. d'Annunzio" University, Chieti, Italy; The Texas Heart Institute and Center for Cardiovascular Biology and Atherosclerosis Research, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, United States. Electronic address: rmadonna@unich.it.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Madonna
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D057791:Cardiac Imaging Techniques / Q000379:methods*; D066126:Cardiotoxicity / Q000175:diagnosis; D042241:Early Diagnosis; D006333:Heart Failure / Q000139:chemically induced / Q000175:diagnosis*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents
keywords: Anticancer therapy; Cardiac imaging; Cardiotoxicidad; Cardiotoxicity; Imagen cardiaca; Omics; Tecnología «ómica»; Terapia antineoplásica