title: Impaired Pulmonary Function in Patients with Psoriasis.
abstract: BACKGROUND
  Psoriasis is associated with chronic obstructive pulmonary disease. There is no study on the spirometric pulmonary function testing in patients with psoriasis.
  
  
  OBJECTIVE
  The aim of this study was to compare the spirometric parameters in patients with psoriasis and controls.
  
  
  METHODS
  Ninety-six patients with psoriasis and 60 sex- and age-matched control subjects were included in this study. Spirometric pulmonary function testing, including percent forced vital capacity (FVC%), percent forced expiratory volume in the 1st second (FEV1%), forced expiratory flow at 25-75% of FVC (FEF25-75%), and FEV1/FVC ratio, was performed in all study subjects.
  
  
  RESULTS
  The mean FEV1/FVC ratio and FEF25-75% were significantly lower in the psoriasis patients than in the controls (82.4 ± 6.3 vs. 90.7 ± 10.7, p < 0.001, and 86.7 ± 24.2 vs. 94.8 ± 23.0, p = 0.04, respectively). Both FEV1/FVC ratio and FEF25-75% were significantly associated with the presence of psoriasis (p < 0.001 and p = 0.029, respectively).
  
  
  CONCLUSIONS
  Psoriasis patients had lower mean FEV1/FVC ratios and FEF25-75%, compared with the control subjects. FEV1/FVC and FEF25-75% are independently associated with the presence of psoriasis.
authors.affiliation: Department of Dermatology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
authors.forename: Didem Didar
authors.initials: DD
authors.lastname: Balci
authors.forename: Ebru
authors.initials: E
authors.lastname: Celik
authors.forename: Sebahat
authors.initials: S
authors.lastname: Genc
authors.forename: Muhammet Murat
authors.initials: MM
authors.lastname: Çelik
authors.forename: Mehmet Ugur
authors.initials: MU
authors.lastname: Inan
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications / Q000628:therapy*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000175:diagnosis; D013147:Spirometry
keywords: Chronic obstructive pulmonary disease; Psoriasis; Pulmonary function; Spirometry