title: Antiparasitic activity of 1,3-dioxolanes containing tellurium in Trichomonas vaginalis.
abstract: The increased prevalence of metronidazole-resistant infections has resulted in a search for alternative drugs for the treatment of trichomoniasis. In the present study, we report the preparation and in vitro activity of three 1,3-dioxolanes that contain tellurium (PTeDOX 01, PTeDOX 02, and PTeDOX 03) against Trichomonas vaginalis. Six concentrations of these compounds were analyzed for in vitro activity against ATCC 30236 isolate of T. vaginalis. PTeDOX 01 reported a cytotoxic effect against 100% of T. vaginalis trophozoites at a final concentration of 90μM with an IC50of 60μM. The kinetic growth curve of trophozoites indicated that PTeDOX 01 reduced the growth by 22% at a concentration of 90μM after an exposure of 12h, and induced complete parasite death at 24h. It induced cytotoxicity of 44% at 90μM concentration but and had no effect in lower concentrations in a culture of CHO-K1 cells. These results confirmed that PTeDOX 01 is an important drug for the treatment of T. vaginalis, and should be evaluated in other infectious agents as well.
authors.affiliation: Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil. Electronic address: angelasena@ymail.com.
authors.forename: Ângela
authors.initials: Â
authors.lastname: Sena-Lopes
authors.affiliation: Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil.
authors.forename: Raquel Nascimento
authors.initials: RN
authors.lastname: das Neves
authors.affiliation: Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil.
authors.forename: Francisco Silvestre Brilhante
authors.initials: FSB
authors.lastname: Bezerra
authors.affiliation: Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil.
authors.forename: Mara Thais
authors.initials: MT
authors.lastname: de Oliveira Silva
authors.affiliation: LASOL-CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, Pelotas, RS 96010-900, Brazil.
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Nobre
authors.affiliation: LASOL-CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, Pelotas, RS 96010-900, Brazil.
authors.forename: Gelson
authors.initials: G
authors.lastname: Perin
authors.affiliation: LASOL-CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, Pelotas, RS 96010-900, Brazil.
authors.forename: Diego
authors.initials: D
authors.lastname: Alves
authors.affiliation: Laboratório de Neurobiotecnologia, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil.
authors.forename: Lucielli
authors.initials: L
authors.lastname: Savegnago
authors.affiliation: Laboratório de Biotecnologia do Câncer, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil.
authors.forename: Karine Rech
authors.initials: KR
authors.lastname: Begnini
authors.affiliation: Laboratório de Biotecnologia do Câncer, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil.
authors.forename: Fabiana Kommling
authors.initials: FK
authors.lastname: Seixas
authors.affiliation: Laboratório de Biotecnologia do Câncer, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil.
authors.forename: Tiago
authors.initials: T
authors.lastname: Collares
authors.affiliation: Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil.
authors.forename: Sibele
authors.initials: S
authors.lastname: Borsuk
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology*; D016466:CHO Cells; D002460:Cell Line; D003412:Cricetulus; D004148:Dioxolanes / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests / Q000379:methods; D013691:Tellurium / Q000494:pharmacology*; D014245:Trichomonas Infections / Q000188:drug therapy; D014246:Trichomonas vaginalis / Q000187:drug effects*; D053058:Trophozoites / Q000187:drug effects
chemical_list: D000977:Antiparasitic Agents; D004148:Dioxolanes; D013691:Tellurium; C010962:formal glycol
keywords: Antiparasitic; Organic tellurium; Trichomonas vaginalis