title: Ascitic fluid drainage using a peritoneal dialysis catheter to prevent and treat multi-organ dysfunction in veno-occlusive disease in children undergoing hematopoietic stem cell transplantation.
abstract: Veno-occlusive disease (VOD), or sinusoidal obstruction syndrome, is a well-recognised, serious complication associated with the chemotherapy conditioning therapy used in hematopoietic stem cell transplantation (HSCT). Fluid management is typically challenging in children with this condition. We describe effective early use of peritoneal dialysis catheters to drain extravascular, intra-abdominal fluid in children with VOD, allowing intravascular fluid administration to preserve renal perfusion and function, preventing multi-organ dysfunction. All but one of the children are long-term survivors, both of their significant VOD and their HSCT. The child that did not survive died from their underlying metabolic illness, not VOD.
authors.affiliation: Blood and Marrow Transplantation Unit, Royal Manchester Children's Hospital, Manchester, UK.
authors.forename: Vijal
authors.initials: V
authors.lastname: Parmar
authors.affiliation: Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Manchester, UK.
authors.forename: Malcolm
authors.initials: M
authors.lastname: Lewis
authors.affiliation: Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Manchester, UK.
authors.forename: Mohan
authors.initials: M
authors.lastname: Shenoy
authors.affiliation: Blood and Marrow Transplantation Unit, Royal Manchester Children's Hospital, Manchester, UK.
authors.forename: Denise
authors.initials: D
authors.lastname: Bonney
authors.affiliation: Blood and Marrow Transplantation Unit, Royal Manchester Children's Hospital, Manchester, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Wynn
mesh_terms: D001201:Ascites / Q000139:chemically induced / Q000628:therapy*; D001202:Ascitic Fluid; D057785:Catheters; D004322:Drainage / Q000295:instrumentation*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced* / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D010530:Peritoneal Dialysis / Q000295:instrumentation; D019172:Transplantation Conditioning / Q000009:adverse effects
keywords: acute kidney injury; hematopoietic stem cell transplantation; multi-organ failure; peritoneal dialysis catheter; veno-occlusive disease