title: Feasibility of laser trabeculoplasty in angle closure glaucoma: a review of favourable histopathological findings in narrow angles.
abstract: Selective laser trabeculoplasty (SLT) has been indicated as a safe and efficient treatment for primary open-angle glaucoma; however, recent studies have also shown positive results with the use of SLT in some clinical conditions related to primary angle-closure glaucoma (PACG). Despite the potential benefits of SLT in selected cases of PACG, the mechanisms underlying the modifications in the trabecular meshwork tissue of patients with PACG are poorly understood. This narrative review approached both the current, limited knowledge about the histological changes observed in different forms of PACG and the clinical results of SLT treatment for PACG. Favourable outcomes of SLT in patients with PACG, specifically in areas of non-occluded angle, need further substantiation through large controlled clinical trials. A deeper understanding of the biomolecular changes of those areas is essential to improve both laser technical details and the clinical efficacy of SLT therapy.
authors.affiliation: Department of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
authors.forename: Alexis Galeno
authors.initials: AG
authors.lastname: Matos
authors.affiliation: Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Sanjay G
authors.initials: SG
authors.lastname: Asrani
authors.affiliation: Department of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.|Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Jayter Silva
authors.identifier: http://orcid.org/0000-0002-8111-3810
authors.initials: JS
authors.lastname: Paula
mesh_terms: D005240:Feasibility Studies; D015812:Glaucoma, Angle-Closure / Q000473:pathology / Q000601:surgery*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D007498:Iris / Q000601:surgery / Q000648:ultrastructure*; D053685:Laser Therapy / Q000379:methods*; D046529:Microscopy, Electron, Transmission; D014129:Trabecular Meshwork / Q000601:surgery / Q000648:ultrastructure*; D014130:Trabeculectomy / Q000379:methods*
keywords: ALT; SLT; angle-closure glaucoma; trabeculoplasty