title: Severe sclerosing cholangitis after Langerhans cell histiocytosis treated by liver transplantation: An adult case report.
abstract: BACKGROUND
  Langerhans cell histiocytosis (LCH) is a rare hematopoietic disorder of unknown pathogenesis. LCH diseases may occur in a single organ or multisystem organ. The patients with multisystem involvement usually have a poor prognosis. Liver involvement in multisystem LCH results in severe complications, such as obvious sclerosing cholangitis (SC) with jaundice.
  
  
  METHODS
  We reported a 31-year-old man developed severe SC due to multisystem LCH and was successfully treated by liver transplantation (LT). In addition, we firstly used tacrolimus and mycofenolate mofetil as immunosuppressants to treat LCH after LT.
  
  
  RESULTS
  We performed the immunosuppressants to deal with the LCH after LT, now the patient is currently well with normal liver function and no evidence of recurrence of LCH for 4 and a half years follow-up.
  
  
  CONCLUSIONS
  LT should be recommended as an effective treatment for these adults with severe SC due to multisystem LCH. Finally, using tacrolimus and mycofenolate mofetil as immunosuppressants to treat LCH might be favorable to prevent LCH recurrence.
authors.affiliation: Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Yunhua
authors.initials: Y
authors.lastname: Tang
authors.forename: Zhiheng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Maogen
authors.initials: M
authors.lastname: Chen
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Ju
authors.forename: Dongping
authors.initials: D
authors.lastname: Wang
authors.forename: Fei
authors.initials: F
authors.lastname: Ji
authors.forename: Qingqi
authors.initials: Q
authors.lastname: Ren
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Guo
authors.forename: Xiaoshun
authors.initials: X
authors.lastname: He
mesh_terms: D000328:Adult; D015209:Cholangitis, Sclerosing / Q000209:etiology* / Q000601:surgery; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications*; D006801:Humans; D016031:Liver Transplantation; D008297:Male