title: [Reseach Advances on Cancer-Testis Antigens in Multiple Myeloma -Review].
abstract: Cancer-testis antigens (CTA) are a class of tumor-associated antigens, which are mainly located in X chromosome. CTA restrictively expressed in normal testis, ovary, placenta and so on. Their expression in other normal tissues is much lower, even can not be detected. However, their expressions are aberrantly high in human cancers. Based on CTA encoding immunogenic proteins, they can be regulated by epigentics, CTA provides very attractive targets for cancer immunotherapy. Multiple myeloma (MM) is incurable and has a low cureative rate and a high relapse rate. CTA have been detected in many MM cell lines and primary MM cells, they may be relaled to clinical prognosis. This reviews briefly summarized the research advances of CTA in the immune therapy of multiple myeloma, so as to provide a valuable therapeutic idea for myeloma.
authors.affiliation: Chinese PLA Medical College,Department of Hematology of Chinese PLA General Hospital,Beijing 100853,China.
authors.forename: Zhi-Rui
authors.initials: ZR
authors.lastname: Yang
authors.affiliation: Chinese PLA Medical College,Department of Hematology of Chinese PLA General Hospital,Beijing 100853,China.
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.affiliation: Chinese PLA Medical College,Department of Hematology of Chinese PLA General Hospital,Beijing 100853,China. E-mail:hyzhu1975@163.com.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhu
mesh_terms: D000951:Antigens, Neoplasm; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000276:immunology*; D009363:Neoplasm Proteins; D009364:Neoplasm Recurrence, Local; D013737:Testis
chemical_list: D000951:Antigens, Neoplasm; D009363:Neoplasm Proteins