title: Non-uniform Progression of Chronic Tubulointerstitial Nephritis and Widespread Nephrocalcification in a Patient with Anorexia Nervosa.
abstract: Although patients with anorexia nervosa (anorexia) are known to show tubulointerstitial nephritis (TIN), the pathophysiology of its progression is not fully understood. We herein report a 31-year-old woman with anorexia who showed acute exacerbation of chronic kidney disease. Renal biopsy showed non-uniform chronic TIN; some areas were obsolete lesions and other areas were active lesions. In addition, many calcium-containing crystals were widely deposited in the distal tubules. The results suggest that chronic TIN in the setting of anorexia does not uniformly progress and that not only TIN but also widespread calcification of distal tubules might aggravate the renal function of anorexia patients.
authors.affiliation: Department of Nephrology, National Center for Global Health and Medicine, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Maki
authors.initials: M
authors.lastname: Shibata
authors.forename: Makoto
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Katsuki
authors.forename: Manami
authors.initials: M
authors.lastname: Tada
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Hinoshita
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications*; D001706:Biopsy; D002114:Calcinosis / Q000209:etiology* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D009395:Nephritis, Interstitial / Q000209:etiology* / Q000473:pathology; D051436:Renal Insufficiency, Chronic / Q000209:etiology* / Q000473:pathology