title: Association of blood pressure in the supine position with target organ damage in subjects over 60 years old.
abstract: Objective Toexplore the correlation between blood pressure in the supine position and target organ damage in subjects over 60 years of age. Methods In 2444 individuals, we investigated the association of systolic blood pressure (SBP) in the supine position with the target organ damage indices microalbuminuria (ALBU), brachial-ankle pulse wave velocity (baPWV), and carotid intima-media thickness (IMT). Supine hypertension (SH) is defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg. Subjects were assigned to either the SH group (1275 cases) or the non-SH group (1169 cases). Results The levels of ALBU, baPWV, and IMT, as well as the percentage of participants with ALBU > 30 mg/L, baPWV ≥ 1400 cm/s, and IMT ≥ 1 mm, were significantly higher in the SH group than in the non-SH group. Multivariate logistic regression analysis showed that SH was an independent risk factor for baPWV and IMT, but the relationship with ALBU was not statistically significant after correction for confounding factors. Conclusions SH is a risk factor for target organ damage, as expressed by the indices baPWV and IMT. The association of SH with kidney damage requires further study.
authors.affiliation: 1 Sixth Hospital of Peking University, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: 2 North China University of Science and Technology, Tangshan, China.
authors.forename: Hualing
authors.initials: H
authors.lastname: Zhao
authors.affiliation: 3 Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.affiliation: 4 Medical Informatics Center, Peking University, Beijing, China.
authors.forename: Guilan
authors.initials: G
authors.lastname: Kong
authors.affiliation: 2 North China University of Science and Technology, Tangshan, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Song
authors.affiliation: 2 North China University of Science and Technology, Tangshan, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Li
authors.affiliation: 2 North China University of Science and Technology, Tangshan, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 5 Cardiology Department of Hebei United University, Affiliated Kailuan General Hospital, Tangshan, China.
authors.forename: Shuohua
authors.initials: S
authors.lastname: Chen
authors.affiliation: 4 Medical Informatics Center, Peking University, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: 5 Cardiology Department of Hebei United University, Affiliated Kailuan General Hospital, Tangshan, China.
authors.forename: Shouling
authors.initials: S
authors.lastname: Wu
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D055109:Ankle Brachial Index; D001783:Blood Flow Velocity; D001794:Blood Pressure; D059168:Carotid Intima-Media Thickness; D002681:China; D015331:Cohort Studies; D003971:Diastole; D005260:Female; D006282:Health Personnel; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D006977:Hypertension, Renal / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011187:Posture; D063177:Pulse Wave Analysis; D012307:Risk Factors; D016683:Supine Position; D013599:Systole
keywords: Aged; arteriosclerosis; chronic; hypertension; renal insufficiency; supine position