title: Compliments of Factor H: What's in it for AMD?
abstract: Genetic variations in complement factor H (CFH) confer greater risk for age-related macular degeneration (AMD). In this issue of Immunity, Calippe et al. (2017) uncover a non-canonical role for CFH in the inhibition of mononuclear phagocyte elimination from sub-retinal lesions, providing insight into the pathophysiology of AMD associated with CFH variants.
authors.affiliation: National Eye Institute, Bethesda, MD 20892, USA.
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Mattapallil
authors.affiliation: National Eye Institute, Bethesda, MD 20892, USA. Electronic address: caspir@nei.nih.gov.
authors.forename: Rachel R
authors.initials: RR
authors.lastname: Caspi
mesh_terms: D017242:Complement Factor H / Q000235:genetics*; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D017242:Complement Factor H