title: Supramolecular Anion Recognition Mediates One-Pot Synthesis of 3-Amino-[1,2,4]-triazolo Pyridines from Thiosemicarbazides.
abstract: A facile one-pot synthesis of 3-amino-[1,2,4]-triazolo[4,3-a]pyridines from thiosemicarbazides through anion mediated synthesis is reported. Thiosemicarbazides derived from 2-hydrazino pyridine, 5-chloro 2-hydrazino pyridine, and 2-hydrazine quinoline were formed in situ as anion receptors in the presence of TBAF. Under microwave heating, thiosemicarbazides furnished the triazolo pyridines in good to moderate yields. The formation of the thiosemicarbazides hydrogen bonding anion receptors was critical in cascading the reaction toward the formation of the triazolo pyridines.
authors.affiliation: School of Chemistry, Trinity College Dublin and Trinity Biomedical Science Institute (TBSI), The University of Dublin , Dublin 2, Ireland.
authors.forename: Komala
authors.initials: K
authors.lastname: Pandurangan
authors.affiliation: School of Chemistry, Trinity College Dublin and Trinity Biomedical Science Institute (TBSI), The University of Dublin , Dublin 2, Ireland.
authors.forename: Anna B
authors.initials: AB
authors.lastname: Aletti
authors.affiliation: School of Chemistry, Trinity College Dublin and Trinity Biomedical Science Institute (TBSI), The University of Dublin , Dublin 2, Ireland.
authors.forename: Devis
authors.initials: D
authors.lastname: Montroni
authors.affiliation: School of Chemistry, Trinity College Dublin and Trinity Biomedical Science Institute (TBSI), The University of Dublin , Dublin 2, Ireland.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Kitchen
authors.affiliation: School of Chemistry, Trinity College Dublin and Trinity Biomedical Science Institute (TBSI), The University of Dublin , Dublin 2, Ireland.
authors.forename: Miguel
authors.initials: M
authors.lastname: Martínez-Calvo
authors.affiliation: School of Chemistry, Trinity College Dublin and Trinity Biomedical Science Institute (TBSI), The University of Dublin , Dublin 2, Ireland.
authors.forename: Salvador
authors.initials: S
authors.lastname: Blasco
authors.affiliation: School of Chemistry, Trinity College Dublin and Trinity Biomedical Science Institute (TBSI), The University of Dublin , Dublin 2, Ireland.
authors.forename: Thorfinnur
authors.identifier: 0000-0003-4814-6853
authors.initials: T
authors.lastname: Gunnlaugsson
authors.affiliation: School of Chemistry, Trinity College Dublin and Trinity Biomedical Science Institute (TBSI), The University of Dublin , Dublin 2, Ireland.
authors.forename: Eoin M
authors.identifier: 0000-0001-5176-2310
authors.initials: EM
authors.lastname: Scanlan