title: First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections.
abstract: We report the case of a patient with acute necrotizing colitis due to invasive amebiasis associated with CD4 lymphopenia and impaired neutrophil responses. The course of the disease was characterized by CMV reactivation and severe and recurrent bacterial and fungal infections, which might be related to the decreased CD4 T cell count and the impaired functional capacities of neutrophils, respectively. The clinical outcome was positive with normalization of both CD4 cell count and neutrophil functions.
authors.affiliation: AP-HP, Hôpital Saint-Antoine, Service des Maladies Infectieuses et Tropicales Paris, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Ghrenassia
authors.affiliation: Département d'Immunologie, AP-HP, Hôpital Pitié-SalpêtrièreParis, France; DHU FAST, CR7, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, UPMC Univ Paris 06Paris, France; Institut National de la Santé et de la Recherche Médicale, U1135, Centre d'Immunologie et des Maladies Infectieuses-ParisParis, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Guihot
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Centre de Recherche Saint-Antoine, UMR-S 938 Paris, France.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Dong
authors.affiliation: DHU FAST, CR7, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, UPMC Univ Paris 06Paris, France; Institut National de la Santé et de la Recherche Médicale, U1135, Centre d'Immunologie et des Maladies Infectieuses-ParisParis, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Robinet
authors.affiliation: Institut Pasteur, Unité des Aspergillus Paris, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Fontaine
authors.affiliation: AP-HP, Hôpital Saint-Antoine, Service des Maladies Infectieuses et Tropicales Paris, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Lacombe
authors.affiliation: Unité de Réanimation Chirurgicale Digestive, Département D'anesthésie et de Réanimation Chirurgicale, AP-HP, Hôpital Saint-Antoine Paris, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lescot
authors.affiliation: AP-HP, Hôpital Saint-Antoine, Service des Maladies Infectieuses et Tropicales Paris, France.
authors.forename: Marie-Caroline
authors.initials: MC
authors.lastname: Meyohas
authors.affiliation: DHU FAST, CR7, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, UPMC Univ Paris 06Paris, France; Institut National de la Santé et de la Recherche Médicale, U1135, Centre d'Immunologie et des Maladies Infectieuses-ParisParis, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Elbim
keywords: CD4 T cells; amebiasis; aspergillosis; cytomegalovirus; neutrophils