title: Mitochondrial homeostasis in adipose tissue remodeling.
abstract: Mitochondrial homeostasis is regulated by a balance between mitochondrial biogenesis and degradation. Emerging evidence suggests that mitophagy, a selective form of autophagy that degrades mitochondria, plays a key role in the physiology and pathophysiology of mitochondria-enriched cells, such as brown and beige adipocytes. This review discusses findings regarding the roles of autophagy and mitophagy in cellular development, maintenance, and functions of metabolic organs, including adipose tissue, liver, and pancreas. A better understanding of the molecular links between mitophagy and energy metabolism will help to identify promising targets for the treatment of obesity and obesity-associated disorders.
authors.affiliation: UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 94143-0669, USA.|Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143-0669, USA.|Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143-0669, USA.
authors.forename: Svetlana
authors.identifier: 0000-0002-5877-9083
authors.initials: S
authors.lastname: Altshuler-Keylin
authors.affiliation: UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 94143-0669, USA. skajimura@diabetes.ucsf.edu.|Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143-0669, USA.|Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143-0669, USA.
authors.forename: Shingo
authors.identifier: 0000-0003-0672-5910
authors.initials: S
authors.lastname: Kajimura
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D001343:Autophagy; D006706:Homeostasis; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D063306:Mitophagy; D008954:Models, Biological; D010179:Pancreas / Q000378:metabolism*; D015398:Signal Transduction