title: TorsinA regulates the LINC to moving nuclei.
abstract: How LINC complexes are regulated to connect nuclei to the cytoskeleton during nuclear migration is unknown. Saunders et al. (2017.J. Cell Biol.https://doi.org/10.1083/jcb.201507113) show that the AAA+ ATPase torsinA and its partner LAP1 are required for nuclear migration during fibroblast polarization by mediating the dynamics of LINC complexes.
authors.affiliation: Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616 dastarr@ucdavis.edu lsrose@ucdavis.edu.
authors.forename: Daniel A
authors.identifier: 0000-0001-7339-6606
authors.initials: DA
authors.lastname: Starr
authors.affiliation: Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616 dastarr@ucdavis.edu lsrose@ucdavis.edu.
authors.forename: Lesilee S
authors.initials: LS
authors.lastname: Rose
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism*; D009685:Nuclear Envelope / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D018832:Molecular Chaperones; D009687:Nuclear Proteins; D000251:Adenosine Triphosphatases