title: Pediatric community-acquired pneumonia treated with a three-day course of tebipenem pivoxil.
abstract: We evaluated the efficacy and safety of a 3-day treatment regimen of tebipenem pivoxil for pediatric community-acquired pneumonia. Tebipenem pivoxil was administered to 49 patients, and its effectiveness was evaluated in 36 patients 2-4 days after initiation of treatment. Thirty-two patients were cured 7-15 days after initiation of treatment. Body temperature was significantly lower on the day following initial administration (median 38.8 to 37.0 °C, n = 33). Leukocyte counts and C-reactive protein levels were significantly reduced by Day 2-4 of treatment (median 16,100 to 7800 white blood cells/μL, and 5.6 to 1.5 mg/dL, respectively; n = 28). Six of the 49 patients had mild diarrhea. Thus, we concluded that 3-day treatment with tebipenem pivoxil was safe and efficacious for treating pediatric community-acquired pneumonia.
authors.affiliation: Department of Pediatrics, Asahikawa Kosei Hospital, Japan. Electronic address: sakhiro@mac.com.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakata
authors.affiliation: Sotobo Children's Clinic, Medical Corporation Shigyo-no-kai, Japan.
authors.forename: Haruo
authors.initials: H
authors.lastname: Kuroki
authors.affiliation: Department of Pediatrics, Kawasaki Medical School, Japan.
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Ouchi
authors.affiliation: Department of Pediatrics, Hakujikai Memorial Hospital, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tajima
authors.affiliation: Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwata
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000378:metabolism; D015780:Carbapenems / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011014:Pneumonia / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D002097:C-Reactive Protein; C500135:tebipenem
keywords: Community-acquired pneumonia; Pediatric; Tebipenem pivoxil