title: Synthesis of Substituted 1,6-Diarylnaphthalenes via a Tandem Claisen Rearrangement and Ene Reaction Protocol.
abstract: In this work, we developed a concise synthetic route for the synthesis of polysubstituted naphthalenes starting from commercially available isovanillin and its derivatives. Reaction with styryl bromide via O-styrylation, Claisen rearrangement, ene reaction, and O-alkylation occurred in high yields. The key structures were confirmed by single-crystal X-ray diffraction.
authors.affiliation: Department of Medicinal and Applied Chemistry, General Research Centers of R&D office, Kaohsiung Medical University Hospital, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
authors.forename: Chieh-Kai
authors.initials: CK
authors.lastname: Chan
authors.affiliation: Department of Medicinal and Applied Chemistry, General Research Centers of R&D office, Kaohsiung Medical University Hospital, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
authors.forename: Yu-Hsin
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Department of Medicinal and Applied Chemistry, General Research Centers of R&D office, Kaohsiung Medical University Hospital, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Tsai
authors.affiliation: Department of Medicinal and Applied Chemistry, General Research Centers of R&D office, Kaohsiung Medical University Hospital, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
authors.forename: Meng-Yang
authors.identifier: 0000-0002-1983-8570
authors.initials: MY
authors.lastname: Chang