title: [The role of pathogenetic therapy in preserving ejaculate fertility in patients with tuberculosis of prostate].
abstract: BACKGROUND
  Genital tuberculosis impairs male reproductive function. Given that tuberculosis of the prostate has been found at autopsy in 77% of men who died of tuberculosis of all locations, the problem is highly relevant.
  
  
  OBJECTIVE
  To develop and test a method of restoring/preserving fertility in patients with prostatic tuberculosis and to evaluate its effectiveness.
  
  
  METHODS
  TThis is an open, prospective, comparative, randomized study, comprising 72 patients with prostatic tuberculosis. Patients of the main group (n=49) received standard TB treatment in combination with pathogenetic spermatoprotective therapy including zinc and selenium based dietary supplement and chorionic gonadotropin. The men in the comparison group (n=23) were treated only with etiotropic TB therapy.
  
  
  RESULTS
  TB treatment had a negative effect on the ejaculate: in the comparison group a two-month course of drug therapy resulted in a decrease in sperm cell count by 23.9%, in the number of actively motile sperm cells by 10.6% and in the number of normal sperm cells by 32.3%. Pathogenetic spermatoprotective therapy increased the sperm cell count by 47.8%, the number of active mobile forms of spermatozoa (total of A and B) by 40.5%, the number of normal sperm cells by 41.9%.
  
  
  CONCLUSIONS
  Spermatoprotective therapy, including human chorionic gonadotropin and zinc and selenium based dietary supplement significantly increases the ejaculate fertility.
authors.affiliation: Novosibirsk Tuberculosis Research Institute of Minzdrav of Russia.|Novosibirsk State Medical University of Minzdrav of Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Kulchavenya
authors.affiliation: Novosibirsk Tuberculosis Research Institute of Minzdrav of Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Osadchii
mesh_terms: D000328:Adult; D005298:Fertility; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011472:Prostatitis / Q000503:physiopathology / Q000628:therapy*; D013076:Sperm Count; D013081:Sperm Motility; D014389:Tuberculosis, Male Genital / Q000503:physiopathology / Q000628:therapy*
keywords: anti-tuberculosis treatment; chemotherapy; ejaculate; infertility; pathogenetic therapy; prostatitis; selenium; spermogram; tuberculosis of prostate; urogenital tuberculosis; zinc