title: Language plasticity after hemispherotomy of the dominant hemisphere in 3 patients: Implication of non-linguistic networks.
abstract: The neural networks involved in language recovery following hemispherotomy of the dominant hemisphere after language acquisition in children remain poorly known. Twelve hemispherotomized children (mean age at surgery: 11.3years) with comparable post-operative neuropsychological patterns underwent multi-task language functional MRI. Three of them had recovered from an initial postoperative aphasia i.e., hemispherotomy was performed on the language-dominant hemisphere. Our main results revealed (1) perisylvian activations in all patients after either left or right hemispherotomy; (2) no differences in activations between groups regarding the side of hemispherotomy; (3) additional activations in pre-frontal (3/3) and hippocampal/parahippocampal and occipito-parietal (2/3) areas, when comparing language activation in each of the three subjects with hemispherotomy of the language-dominant hemisphere to the group of 9 non-dominant hemispherotomized patients. These neural networks support the stronger engagement of learning and memory during language recovery in a hemisphere that was not initially actively subserving language.
authors.affiliation: INSERM U1129 "Infantile Epilepsies and Brain Plasticity", Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France; CEA, Gif sur Yvette, France; Rothschild Foundation Hospital, Pediatric Neurosurgery Department, Paris, France. Electronic address: cbulteau@for.paris.
authors.forename: Christine
authors.initials: C
authors.lastname: Bulteau
authors.affiliation: INSERM U1129 "Infantile Epilepsies and Brain Plasticity", Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France; CEA, Gif sur Yvette, France; Rothschild Foundation Hospital, Pediatric Neurosurgery Department, Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Jambaqué
authors.affiliation: INSERM U1129 "Infantile Epilepsies and Brain Plasticity", Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France; CEA, Gif sur Yvette, France; CEA, I2BM, Neurospin & Orsay, and IFR 49, Saclay, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Chiron
authors.affiliation: INSERM U1129 "Infantile Epilepsies and Brain Plasticity", Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France; CEA, Gif sur Yvette, France; CEA, I2BM, Neurospin & Orsay, and IFR 49, Saclay, France.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Rodrigo
authors.affiliation: Rothschild Foundation Hospital, Pediatric Neurosurgery Department, Paris, France.
authors.forename: Georg
authors.initials: G
authors.lastname: Dorfmüller
authors.affiliation: INSERM U1129 "Infantile Epilepsies and Brain Plasticity", Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France; CEA, Gif sur Yvette, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Dulac
authors.affiliation: INSERM U1129 "Infantile Epilepsies and Brain Plasticity", Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France; CEA, Gif sur Yvette, France; CEA, I2BM, Neurospin & Orsay, and IFR 49, Saclay, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Hertz-Pannier
authors.affiliation: INSERM U1129 "Infantile Epilepsies and Brain Plasticity", Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France; CEA, Gif sur Yvette, France; CEA, I2BM, Neurospin & Orsay, and IFR 49, Saclay, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Noulhiane
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology* / Q000601:surgery; D001931:Brain Mapping / Q000379:methods; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology*; D038421:Hemispherectomy / Q000639:trends*; D006801:Humans; D007802:Language; D007806:Language Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D007807:Language Tests; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000502:physiology* / Q000601:surgery; D009473:Neuronal Plasticity / Q000502:physiology*; D020127:Recovery of Function / Q000502:physiology; D055815:Young Adult
keywords: Aphasia; Hemispherotomy; Language; Language dominance; Language recovery; Plasticity; fMRI