title: Effect of administration of high-protein diet in rats submitted to resistance training.
abstract: OBJECTIVE
  Although there is limited evidence regarding the pathophysiological effects of a high-protein diet (HD), it is believed that this type of diet could overload the body and cause damage to the organs directly involved with protein metabolism and excretion. The aim of this study was to verify the effects of HD on biochemical and morphological parameters of rats that completed a resistance training protocol (RT; aquatic jump) for 8 weeks.
  
  
  METHODS
  Thirty-two adult male Wistar rats were divided into four groups (n = 8 for each group): sedentary normal protein diet (SN-14%), sedentary high-protein diet (SH-35%), trained normal protein diet (TN-14%), and trained high-protein diet (TH-35%). Biochemical, tissue, and morphological measurements were made.
  
  
  RESULTS
  Kidney (1.91 ± 0.34) and liver weights (12.88 ± 1.42) were higher in the SH. Soleus muscle weight was higher in the SH (0.22 ± 0.03) when compared to all groups. Blood glucose (123.2 ± 1.8), triglycerides (128.5 ± 44.0), and HDL cholesterol levels (65.7 ± 20.9) were also higher in the SH compared with the other experimental groups. Exercise reduced urea levels in the trained groups TN and TH (31.0 ± 4.1 and 36.8 ± 6.6), respectively. Creatinine levels were lower in TH and SH groups (0.68 ± 0.12; 0.54 ± 0.19), respectively. HD negatively altered renal morphology in SH, but when associated with RT, the apparent damage was partially reversed. In addition, the aquatic jump protocol reversed the damage to the gastrocnemius muscle caused by the HD.
  
  
  CONCLUSIONS
  A high-protein diet promoted negative metabolic and morphological changes, while RT was effective in reversing these deleterious effects.
authors.affiliation: Federal University of Mato Grosso, Fernando Correa da Costa Avenue, 2367, Boa Esperança, Cuiabá, MT, 78060-600, Brazil.
authors.forename: Thiago
authors.initials: T
authors.lastname: da Rosa Lima
authors.affiliation: Federal University of Mato Grosso, Fernando Correa da Costa Avenue, 2367, Boa Esperança, Cuiabá, MT, 78060-600, Brazil.
authors.forename: Eudes Thiago Pereira
authors.initials: ETP
authors.lastname: Ávila
authors.affiliation: Federal University of Mato Grosso, Fernando Correa da Costa Avenue, 2367, Boa Esperança, Cuiabá, MT, 78060-600, Brazil.
authors.forename: Géssica Alves
authors.initials: GA
authors.lastname: Fraga
authors.affiliation: Federal University of Mato Grosso, Fernando Correa da Costa Avenue, 2367, Boa Esperança, Cuiabá, MT, 78060-600, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: de Souza Sena
authors.affiliation: Federal University of Mato Grosso, Fernando Correa da Costa Avenue, 2367, Boa Esperança, Cuiabá, MT, 78060-600, Brazil.
authors.forename: Arlyson Batista
authors.initials: AB
authors.lastname: de Souza Dias
authors.affiliation: Federal University of Mato Grosso, Fernando Correa da Costa Avenue, 2367, Boa Esperança, Cuiabá, MT, 78060-600, Brazil.
authors.forename: Paula Caroline
authors.initials: PC
authors.lastname: de Almeida
authors.affiliation: Mato Grosso State University, Diamantino, MT, Brazil.
authors.forename: Joice Cristina
authors.initials: JC
authors.lastname: Dos Santos Trombeta
authors.affiliation: Mato Grosso State University, Cáceres, MT, Brazil.
authors.forename: Roberto Carlos Vieira
authors.initials: RCV
authors.lastname: Junior
authors.affiliation: Federal University of Mato Grosso, Fernando Correa da Costa Avenue, 2367, Boa Esperança, Cuiabá, MT, 78060-600, Brazil.
authors.forename: Amílcar Sabino
authors.initials: AS
authors.lastname: Damazo
authors.affiliation: University of Nevada Las Vegas, Las Vegas, NV, USA.
authors.forename: James Wilfred
authors.initials: JW
authors.lastname: Navalta
authors.affiliation: Graduation Program on Physical Education, Catholic University of Brasília, Brasília, DF, Brazil.
authors.forename: Jonato
authors.initials: J
authors.lastname: Prestes
authors.affiliation: Federal University of Mato Grosso, Fernando Correa da Costa Avenue, 2367, Boa Esperança, Cuiabá, MT, 78060-600, Brazil. faunesp8@yahoo.com.br.
authors.forename: Fabrício Azevedo
authors.initials: FA
authors.lastname: Voltarelli
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D003404:Creatinine / Q000097:blood; D000073600:Diet, High-Protein / Q000009:adverse effects; D006943:Hyperglycemia / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D015228:Hypertriglyceridemia / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D006984:Hypertrophy / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D007668:Kidney / Q000166:cytology / Q000254:growth & development / Q000473:pathology; D008099:Liver / Q000166:cytology / Q000254:growth & development / Q000473:pathology; D008297:Male; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000166:cytology / Q000254:growth & development* / Q000473:pathology; D009929:Organ Size; D011897:Random Allocation; D017208:Rats, Wistar; D055070:Resistance Training / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides; D014508:Urea; D003404:Creatinine
keywords: Aquatic jump training; Dietary management; High-protein diet; Resistance training; Tissue morphology