title: WOX14 promotes bioactive gibberellin synthesis and vascular cell differentiation in Arabidopsis.
abstract: Procambial and cambial stem cells provide the initial cells that allow the formation of vascular tissues. WOX4 and WOX14 have been shown to act redundantly to promote procambial cell proliferation and differentiation. Gibberellins (GAs), which have an important role in wood formation, also stimulate cambial cell division. Here we show that the loss of WOX14 function phenocopies some traits of GA-deficient mutants that can be complemented by exogenous GA application, whereas WOX14 overexpression stimulates the expression of GA3ox anabolism genes and represses GA2ox catabolism genes, promoting the accumulation of bioactive GA. More importantly, our data clearly indicate that WOX14 but not WOX4 promotes vascular cell differentiation and lignification in inflorescence stems of Arabidopsis.
authors.affiliation: Saclay Plant Science, Institut de Biologie des Plantes, Univ. Paris-Sud, CNRS, Orsay, 91405, France.
authors.forename: Erwan
authors.initials: E
authors.lastname: Denis
authors.affiliation: Saclay Plant Science, Institut de Biologie des Plantes, Univ. Paris-Sud, CNRS, Orsay, 91405, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Kbiri
authors.affiliation: Saclay Plant Science, Institut de Biologie des Plantes, Univ. Paris-Sud, CNRS, Orsay, 91405, France.
authors.forename: Viviane
authors.initials: V
authors.lastname: Mary
authors.affiliation: Saclay Plant Science, Institut de Biologie des Plantes, Univ. Paris-Sud, CNRS, Orsay, 91405, France.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Claisse
authors.affiliation: Saclay Plant Science, Institut de Biologie des Plantes, Univ. Paris-Sud, CNRS, Orsay, 91405, France.|GQE- Le Moulon, INRA, Univ. Paris-Sud, CNRS, AgroParisTech, Université Paris-Saclay, Gif-sur-Yvette, 91190, France.
authors.forename: Natalia
authors.initials: N
authors.lastname: Conde E Silva
authors.affiliation: Saclay Plant Science, Institut de Biologie des Plantes, Univ. Paris-Sud, CNRS, Orsay, 91405, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Kreis
authors.affiliation: Saclay Plant Science, Institut de Biologie des Plantes, Univ. Paris-Sud, CNRS, Orsay, 91405, France.|GQE- Le Moulon, INRA, Univ. Paris-Sud, CNRS, AgroParisTech, Université Paris-Saclay, Gif-sur-Yvette, 91190, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Deveaux
mesh_terms: D017360:Arabidopsis / Q000166:cytology / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D058506:Cambium / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D018506:Gene Expression Regulation, Plant / Q000235:genetics / Q000502:physiology; D005875:Gibberellins / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D005875:Gibberellins; D018398:Homeodomain Proteins; C581876:WOX14 protein, Arabidopsis
keywords: 
  Arabidopsis thaliana
  ; 
  WOX
  ; cambium; cell differentiation; gibberellin; inflorescence stem; xylem