title: HORMONAL SUPPLEMENTATION TRIGGERING CHOROIDAL NEOVASCULARIZATION IN HEALTHY YOUNG FEMALES.
abstract: OBJECTIVE
  To report three cases of choroidal neovascularization after hormonal treatment for ovarian stimulation during a fertility therapy.
  
  
  METHODS
  A comprehensive ophthalmic examination was performed in all cases including best-corrected visual acuity, color fundus examination, fluorescein angiography, and optical coherence tomography.
  
  
  RESULTS
  Three females in their thirties developed unilateral acuity vision loss and metamorphopsia. They all were undergoing hormonal supplementation for ovarian stimulation with gonadotropins at the moment of presentation. Intravitreal therapy with ranibizumab was used; all cases showed a significant functional and anatomical improvement.
  
  
  CONCLUSIONS
  Hormonal supplementation for fertility therapy is a common procedure that may be associated with the development of choroidal neovascularization in healthy young females. Further studies should be performed to evaluate this association, but both ophthalmologist and gynecologist should be aware of this potential complication.
authors.affiliation: Unit of Macula, Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Dolz-Marco
authors.affiliation: Department of Ophthalmology, University General Hospital, Valencia, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Doménech
authors.affiliation: Department of Ophthalmology, University Hospital of La Ribera, Valencia, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Diago
authors.affiliation: Department of Ophthalmology, University General Hospital, Valencia, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Montero
authors.affiliation: Department of Ophthalmology, University Hospital of La Ribera, Valencia, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: García-Canet
authors.affiliation: Department of Ophthalmology, University General Hospital, Valencia, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Cervera-Taulet
authors.affiliation: Unit of Macula, Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, Spain.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gallego-Pinazo
authors.affiliation: Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: J Fernando
authors.initials: JF
authors.lastname: Arévalo
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D020256:Choroidal Neovascularization / Q000139:chemically induced*; D005260:Female; D006062:Gonadotropins / Q000009:adverse effects*; D006801:Humans; D010062:Ovulation Induction / Q000009:adverse effects*; D016896:Treatment Outcome; D014786:Vision Disorders / Q000139:chemically induced
chemical_list: D020533:Angiogenesis Inhibitors; D006062:Gonadotropins