title: Oxidative stress and brain morphology in individuals with depression, anxiety and healthy controls.
abstract: Oxidative stress is a biological process, caused by an imbalance between reactive oxygen species (ROS) and antioxidants, in favour of the ROS. This imbalance leads to oxidative damage to lipids, proteins and DNA and ultimately cell death. Studies in rodents have shown that the brain, particularly the amygdala and hippocampus, is sensitive to oxidative stress, although studies on the association between oxidative stress and brain morphology in humans are lacking. Oxidative stress has also been associated with major depressive disorder (MDD) and may be related to volumetric abnormalities in the amygdala and hippocampus in MDD and anxiety disorders. In this study we aimed to examine the association between two robust measures of oxidative damage in plasma (8-OHdG and F2-isoprostanes) and volume of the hippocampus and amygdala in a large sample of individuals with and without MDD and/or anxiety (N=297). In secondary analyses, we examine whether this association is similar in patients and controls. 8-OHdG and F2-isoprostanes plasma levels were determined using liquid chromatography tandem mass spectrometry and volume of the hippocampus and amygdala and hippocampal subfields was determined using Freesurfer. We found no association between plasma markers (or interaction with MDD and/or anxiety disorder diagnosis) and subcortical volume, suggesting that peripheral oxidative stress damage is not associated with subcortical brain volume.
authors.affiliation: Department of Psychiatry and Amsterdam Neuroscience, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands. Electronic address: l.vanvelzen@ggzingeest.nl.
authors.forename: Laura S
authors.initials: LS
authors.lastname: van Velzen
authors.affiliation: Department of Psychiatry and Amsterdam Neuroscience, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
authors.forename: Madelief
authors.initials: M
authors.lastname: Wijdeveld
authors.affiliation: Department of Psychiatry, Amsterdam Public Health Institute, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Catherine N
authors.initials: CN
authors.lastname: Black
authors.affiliation: University of Groningen, University Medical Center Groningen, Department of Neuroscience, Section Cognitive Neuropsychiatry, Groningen, The Netherlands.
authors.forename: Marie-Jose
authors.initials: MJ
authors.lastname: van Tol
authors.affiliation: Institute of Psychiatry, Leiden Institute for Brain and Cognition (LIBC), Leiden University, Leiden, The Netherlands.
authors.forename: Nic J A
authors.initials: NJA
authors.lastname: van der Wee
authors.affiliation: Department of Psychiatry and Amsterdam Neuroscience, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
authors.forename: Dick J
authors.initials: DJ
authors.lastname: Veltman
authors.affiliation: Department of Psychiatry and Amsterdam Neuroscience, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands; Department of Psychiatry, Amsterdam Public Health Institute, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Brenda W J H
authors.initials: BWJH
authors.lastname: Penninx
authors.affiliation: Department of Psychiatry and Amsterdam Neuroscience, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands; Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia; Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Lianne
authors.initials: L
authors.lastname: Schmaal
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000679:Amygdala / Q000000981:diagnostic imaging / Q000473:pathology*; D001008:Anxiety Disorders / Q000097:blood / Q000473:pathology; D015331:Cohort Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000097:blood; D003865:Major Depressive Disorder / Q000097:blood / Q000473:pathology; D028441:F2-Isoprostanes / Q000097:blood*; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D028441:F2-Isoprostanes; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine
keywords: 8-OHdG; Amygdala; Brain morphology; Hippocampus; Oxidative stress; f2-Isoprostanes