title: Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats.
abstract: Blood pressure variability (BPV) is associated with the development and progression of severe target organ damage (TOD). This study aims to evaluate the protective effect of paeoniflorin enriched extract from Radix Paeoniae Alba (PG) on BPV and TOD in spontaneously hypertensive rats (SHR). All SHR were orally treated with distilled water, metoprolol (MP, 20 mg/kg), and PG (PG-H, 90 mg/kg or PG-L, 30 mg/kg) for a single time or daily for 7 weeks. The 24-hour dynamic blood pressure was monitored and then calculated BPV including long- and short-term systolic blood pressure variability (SBPV), diastolic blood pressure variability (DBPV), mean blood pressure variability (MBPV), and heart rate variability (HRV) as well as the 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP. The protective effects of PG on TOD were observed by histopathologic and biochemical detection. The results indicated that long- and short-term SBPV, DBPV, MBPV, and HRV as well as 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP showed no significant changes after single-dose administration of PG and significantly decreased after administration with PG for 7 weeks. PG could also markedly improve the damage of aorta, heart, kidney, and brain. This study suggested that PG could notably reduce BPV, stabilize blood pressure, and mitigate TOD in SHR.
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.
authors.forename: Bo
authors.identifier: 0000-0002-1918-8854
authors.initials: B
authors.lastname: Li
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Zhejiang Academy of Medical Sciences, Hangzhou 310053, China.
authors.forename: Zheng-Biao
authors.initials: ZB
authors.lastname: Yang
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Lei
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
authors.forename: Jie
authors.identifier: 0000-0002-1933-5033
authors.initials: J
authors.lastname: Su
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
authors.forename: Min-Xia
authors.identifier: 0000-0002-6645-0536
authors.initials: MX
authors.lastname: Pang
authors.affiliation: Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
authors.forename: Chao
authors.identifier: 0000-0002-9168-1424
authors.initials: C
authors.lastname: Yin
authors.affiliation: Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
authors.forename: Guo-Yang
authors.identifier: 0000-0002-8783-3376
authors.initials: GY
authors.lastname: Chen
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
authors.forename: Chao-Wen
authors.identifier: 0000-0003-1129-6276
authors.initials: CW
authors.lastname: Shan
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
authors.forename: Hui-Ming
authors.identifier: 0000-0003-0704-4367
authors.initials: HM
authors.lastname: Hu
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China; Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
authors.forename: Su-Hong
authors.identifier: 0000-0001-8807-5071
authors.initials: SH
authors.lastname: Chen
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
authors.forename: Gui-Yuan
authors.identifier: 0000-0003-2732-4905
authors.initials: GY
authors.lastname: Lv