title: [Cutaneous involvement in T-lymphoblastic lymphoma].
abstract: BACKGROUND
  Lymphoblastic lymphoma (LBL) is a rare form of non-Hodgkin's lymphoma (NHL). Cutaneous LBL is seen in less than 20% of patients.
  
  
  METHODS
  Herein, we report the case of a 66-year-old male patient without any previous disease history of note and who was presenting a gradually spreading tumoral lesion of the scalp, several purplish macules and nodules on the trunk, and a single spinal adenopathy. A thoracic-abdominal-pelvic CT scan performed for acute renal failure, revealed extensive infiltration of retroperitoneal tissue. Skin biopsies and staging tests indicated LBL-T with associated cutaneous, bone and lymph node retroperitoneal lesions with no mediastinal mass. After two months of treatment with CHOP (four courses), the cutaneous lesions and abdominal tumoral mass had regressed and renal function had returned to normal.
  
  
  CONCLUSIONS
  There have been 13 reported cases of LBL with cutaneous involvement; most of these patients were young (under 30 years) and presented multiple cutaneous lesions (nodules or tumors) associated with numerous peripheral adenopathies, invasion of the bone marrow, and in many cases, a mediastinal mass. The clinical presentation of LBL-T in our case is novel on account of the cutaneous sites, associated with abdominal tumoral syndrome, without mediastinal infiltration, and with a single peripheral adenopathy, in an elderly subject.
authors.affiliation: Service de dermatologie, CHU de Caen, avenue de la Côte-de-Nacre, 14033 Caen, France; Université de Caen Normandie, 14000 Caen, France. Electronic address: clara.nascimbeni@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Nascimbeni
authors.affiliation: Service d'hématologie clinique, CHU de Caen, 14033 Caen, France; Université de Caen Normandie, 14000 Caen, France.
authors.forename: S
authors.initials: S
authors.lastname: Chantepie
authors.affiliation: Service de dermatologie, CHU de Caen, avenue de la Côte-de-Nacre, 14033 Caen, France; Université de Caen Normandie, 14000 Caen, France.
authors.forename: C
authors.initials: C
authors.lastname: Brugiere
authors.affiliation: Service d'anatomie pathologique, CHU de Caen, 14033 Caen, France; Université de Caen Normandie, 14000 Caen, France.
authors.forename: F
authors.initials: F
authors.lastname: Comoz
authors.affiliation: Service d'hématologie biologique, CHU de Caen, 14033 Caen, France; Université de Caen Normandie, 14000 Caen, France.
authors.forename: V
authors.initials: V
authors.lastname: Salaun
authors.affiliation: Service de dermatologie, CHU de Caen, avenue de la Côte-de-Nacre, 14033 Caen, France; Université de Caen Normandie, 14000 Caen, France.
authors.forename: L
authors.initials: L
authors.lastname: Verneuil
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001842:Bone and Bones / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D016130:Immunophenotyping; D017254:Leukemic Infiltration / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D009928:Organ Specificity; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000008:administration & dosage; D012187:Retroperitoneal Space; D012867:Skin / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D015122:Mercaptopurine; D011241:Prednisone; D008727:Methotrexate
keywords: Cutaneous involvement; Localisation cutanée; Lymphome lymphoblastique T; T-lymphoblastic lymphoma