title: PROSPECTIVE COMPARISON OF TUMOR STAGING USING COMPUTED TOMOGRAPHY VERSUS MAGNETIC RESONANCE IMAGING FINDINGS IN DOGS WITH NASAL NEOPLASIA: A PILOT STUDY.
abstract: Identification of nasal neoplasia extension and tumor staging in dogs is most commonly performed using computed tomography (CT), however magnetic resonance imaging (MRI) is routinely used in human medicine. A prospective pilot study enrolling six dogs with nasal neoplasia was performed with CT and MRI studies acquired under the same anesthetic episode. Interobserver comparison and comparison between the two imaging modalities with regard to bidimensional measurements of the nasal tumors, tumor staging using historical schemes, and assignment of an ordinal scale of tumor margin clarity at the tumor-soft tissue interface were performed. The hypotheses included that MRI would have greater tumor measurements, result in higher tumor staging, and more clearly define the tumor soft tissue interface when compared to CT. Evaluation of bone involvement of the nasal cavity and head showed a high level of agreement between CT and MRI. Estimation of tumor volume using bidimensional measurements was higher on MRI imaging in 5/6 dogs, and resulted in a median tumor volume which was 18.4% higher than CT imaging. Disagreement between CT and MRI was noted with meningeal enhancement, in which two dogs were positive for meningeal enhancement on MRI and negative on CT. One of six dogs had a higher tumor stage on MRI compared to CT, while the remaining five agreed. Magnetic resonance imaging resulted in larger bidimensional measurements and tumor volume estimates, along with a higher likelihood of identifying meningeal enhancement when compared to CT imaging. Magnetic resonance imaging may provide integral information for tumor staging, prognosis, and treatment planning.
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616.|Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, 2407 River Dr, Knoxville, TN, 37996.
authors.forename: Cassie N
authors.initials: CN
authors.lastname: Lux
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616.
authors.forename: William T N
authors.initials: WTN
authors.lastname: Culp
authors.affiliation: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616.
authors.forename: Lynelle R
authors.initials: LR
authors.lastname: Johnson
authors.affiliation: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616.
authors.forename: Michael
authors.initials: M
authors.lastname: Kent
authors.affiliation: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616.
authors.forename: Philipp
authors.initials: P
authors.lastname: Mayhew
authors.affiliation: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616.|Antech Imaging Services, Flumet, France, 73590.
authors.forename: Lise A
authors.initials: LA
authors.lastname: Daniaux
authors.affiliation: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616.|Seattle Veterinary Specialists, Kirkland, WA, 98034.
authors.forename: Alaina
authors.initials: A
authors.lastname: Carr
authors.affiliation: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616.|Circle Oak Equine Sports Medicine and Rehabilitation, Petaluma, CA, 94954.
authors.forename: Sarah
authors.initials: S
authors.lastname: Puchalski
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000000981:diagnostic imaging*; D004285:Dogs; D005260:Female; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000662:veterinary*; D008297:Male; D009367:Neoplasm Staging / Q000379:methods*; D009669:Nose Neoplasms / Q000000981:diagnostic imaging / Q000662:veterinary*; D010865:Pilot Projects; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000662:veterinary*
keywords: CT; MRI; nasal; neoplasia; stage