title: Necrotizing suppurative nephritis in a Japanese black feedlot steer due to Proteus mirabilis infection.
abstract: A Japanese black feedlot steer suddenly died after exhibiting astasia and cramping of the extremities. Necropsy of the animal revealed that the right kidney was enlarged and pale with severe nephrolithiasis. The urinary bladder displayed mucosal hemorrhage. Upon bacteriological investigation, Proteus mirabilis was isolated from the liver, spleen, right kidney, lungs and urine. Histopathological examination revealed necrotizing suppurative nephritis with the presence of numerous gram-negative bacilli and fibrinous suppurative cystitis with no bacilli. Immunohistochemical analysis revealed that the bacteria and cytoplasm of the macrophages stained positively with P. mirabilis antiserum. Electron microscopy revealed the presence of numerous bacteria in the renal tubules. To our knowledge, this is the first report describing the histopathological aspects of nephritis caused by P. mirabilis in cattle.
authors.affiliation: Tochigi Prefectural Kenou Livestock Hygiene Service Center, 6-8 Hiraidekogyodanchi, Utsunomiya, Tochigi 321-0905, Japan.
authors.forename: Tadatsugu
authors.initials: T
authors.lastname: Abe
authors.forename: Ayako
authors.initials: A
authors.lastname: Iizuka
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kojima
authors.forename: Kumiko
authors.initials: K
authors.lastname: Kimura
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shibahara
authors.forename: Makoto
authors.initials: M
authors.lastname: Haritani
mesh_terms: D000818:Animals; D003670:Deer / Q000382:microbiology*; D008297:Male; D009393:Nephritis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D011512:Proteus Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D011513:Proteus mirabilis