title: Is cerebral vasomotor reactivity impaired in Parkinson disease?
abstract: The ability of a blood vessel to change diameter in response to a change in carbon dioxide concentration is often referred to as vasomotor reactivity. This study aimed to determine whether vasomotor reactivity is impaired in patients with idiopathic Parkinson's Disease in comparison to healthy controls.
  
  
  
  Transcranial Doppler was used to measure cerebral blood flow velocity in the middle cerebral arteries at baseline and under hypocapnic conditions in 40 patients with idiopathic Parkinson's disease and 50 healthy controls.
  
  
  
  Vasomotor reactivity, assessed under hypocapnic conditions, is not impaired in patients with idiopathic Parkinson's Disease in comparison to healthy controls.
authors.affiliation: Department of Neurophysiology, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK. marthahanby@hotmail.com.
authors.forename: Martha F
authors.initials: MF
authors.lastname: Hanby
authors.affiliation: Department of Cardiovascular Sciences, Leicester Royal Infirmary, Level 4 Robert Kilpatrick Sciences Building, Leicester, LE2 7LX, UK.
authors.forename: Ronney B
authors.initials: RB
authors.lastname: Panerai
authors.affiliation: Department of Cardiovascular Sciences, Leicester Royal Infirmary, Level 2 Robert Kilpatrick Sciences Building, Leicester, LE2 7LX, UK.
authors.forename: Thompson G
authors.initials: TG
authors.lastname: Robinson
authors.affiliation: Department of Cardiovascular Sciences, Leicester Royal Infirmary, Level 2 Victoria Building, Infirmary Square, Leicester, LE1 5WW, UK.
authors.forename: Victoria J
authors.initials: VJ
authors.lastname: Haunton
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006935:Hypercapnia / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D017585:Ultrasonography, Doppler, Transcranial; D014666:Vasomotor System / Q000000981:diagnostic imaging* / Q000503:physiopathology*
keywords: Dopamine; Hypocapnia; Idiopathic Parkinsonʼs disease; Transcranial Doppler; Vasomotor reactivity