title: Is Imprint Cytology Useful to Diagnose Malignancy for Brenner Tumors? A Case Series at a Single Institute.
abstract: BACKGROUND
  The aim of this study was to investigate cytological features of Brenner tumors according to tumor grade using imprint cytology.
  
  
  METHODS
  Between 2004 and 2015, intraoperative imprint cytology was performed on 8 patients with Brenner tumors suspected to be malignant neoplasmas on gross examination because of their large size and solid part. These consisted of 1 benign, 3 borderline, and 4 malignant tumors. In patients with benign and borderline tumors, naked nucleus-like stromal cells and tumor cells in a sheet-like arrangement were observed against a clear background. The nuclei were round to oval-shaped with finely granular chromatin patterns and small nucleoli. Papillary cell clusters and high nucleus-to-cytoplasm ratios were only observed in 1 borderline case. In cases with malignancy, the background was necrotic. The tumor cells occurred in large papillary clusters. The nuclei showed a high degree of nuclear atypia. Nuclear grooves were present in 6 of our 8 cases and they were scant in the malignant cases.
  
  
  CONCLUSIONS
  Imprint cytology of Brenner tumors provided no characteristic findings to enable a definitive distinction of benign versus borderline tumors, but it enabled discrimination between malignant and other tumors. Imprint cytology can facilitate intraoperative diagnosis and aid in selecting the appropriate surgical procedure.
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Minato
authors.forename: Hideki
authors.initials: H
authors.lastname: Tokunaga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okamoto
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shibuya
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Niikura
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001948:Brenner Tumor / Q000175:diagnosis* / Q000473:pathology; D002466:Cell Nucleolus / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology*; D053144:Cell Nucleus Shape; D053145:Cell Nucleus Size; D003581:Cytodiagnosis / Q000379:methods*; D005260:Female; D006801:Humans; D007564:Japan; D008875:Middle Aged; D060787:Neoplasm Grading; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies; D047368:Tumor Burden
keywords: Brenner tumor; Imprint cytology; Ovary