title: [Effect of gender on the prognosis of patients with non-small cell lung cancer].
abstract: Objective:To analyze the effect of gender on the prognosis of patients with non-small cell lung cancer (NSCLC).Methods:Data of 1 195 patients with NSCLC were analyzed byChi-square, Kaplan-Meier, log-rank tests and Cox regression models.Results:Women had a longer survival than men (median overall survival 31.64 versus 22.71 months,P<0.01) in the participants of this study. Differences seen in overall survival remained the similar, after stratified by age, pathologic types, clinical stage, sizes, pleural effusion and surgery of the patients, respectively. Data from the multivariate analysis revealed that factors as smoking, clinical stage, metastatic when diagnosis was made and surgery, but not gender, were independent prognostic factors for patients with NSCLC. After adjustment for potential confounders, we found that smoking was a major confounding factor, affecting the relationship between gender and prognosis of NSCLC.Conclusion:Gender did not seem an independent prognostic factor for NSCLC patients while the survival advantages of females might be attributed to the lower prevalence of smoking in this population.
authors.affiliation: Department of Epidemiology and Health Statistics, The First Affiliated Hospital Fujian Medical University, Fuzhou 350108, China.
authors.forename: Q P
authors.initials: QP
authors.lastname: Xu
authors.affiliation: Department of Epidemiology and Health Statistics, The First Affiliated Hospital Fujian Medical University, Fuzhou 350108, China.
authors.forename: F
authors.initials: F
authors.lastname: He
authors.affiliation: Department of Epidemiology and Health Statistics, The First Affiliated Hospital Fujian Medical University, Fuzhou 350108, China.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Health Statistics, The First Affiliated Hospital Fujian Medical University, Fuzhou 350108, China.
authors.forename: W M
authors.initials: WM
authors.lastname: Xiong
authors.affiliation: School of Public Health, Department of Chest Surgery, The First Affiliated Hospital Fujian Medical University, Fuzhou 350108, China.
authors.forename: J B
authors.initials: JB
authors.lastname: Lin
authors.affiliation: Department of Epidemiology and Health Statistics, The First Affiliated Hospital Fujian Medical University, Fuzhou 350108, China.
authors.forename: L
authors.initials: L
authors.lastname: Cai
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000401:mortality*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000175:diagnosis / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012737:Sex Factors; D012907:Smoking; D016019:Survival Analysis; D015996:Survival Rate
keywords: Non-small cell lung cancer; Prognosis; Sex