title: 'Her shape' intervention programme for obese women with high breast adiposity.
abstract: OBJECTIVE
  Nutrition and physical activity interventions is beneficial in reversing obesity. However far too little attention has been paid to the effect of these interventions on breast tissues. Thus, the aim of this study was to explore the effect of a home-based dietary and physical activity intervention (the Her Shape Program) on metabolic parameters, blood biomarkers and adiposity at the breast.
  
  
  METHODS
  A randomized controlled study was conducted on obese women with high breast adiposity (<0.1 Sm-1), aged 40-60 years in Klang Valley, Malaysia. Subjects were assigned to intervention (n=16) and control group (n=15). Intervention group received a home based health education package with close monitoring weekly, personal diet consultation and physical training in group. Assessment was ascertained at three time points; baseline, weeks 8 and 16. Outcome measures were the energy intake, physical activity, body composition, blood tests, blood biomarkers and electrical impedance tomography (EIT) quantitative values. Analyses were done using 2-way repeated measures ANOVA.
  
  
  CONCLUSIONS
  All subjects completed the program without any drop-out. The HSI group had 100% compliance towards the intervention program; their energy intake was reduced for approximately 35% and their activity score was increased for approximately 11%. A significant interaction effect was found in body weight, body mass index (BMI), total cholesterol/HDL, vitamin C intake and matrix metallopeptidase 9 (MMP-9) (p<0.05). Interestingly, their EIT extremum values were also significantly increased indicating a reduction of breast adiposity. The intervention program was successful in improving body composition, physical activities, MMP9 and breast adipose tissue composition.
authors.affiliation: Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia.
authors.forename: Norsham
authors.initials: N
authors.lastname: Juliana
authors.affiliation: Dietetics Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia. Email: suzana.shahar@gmail.com; orsha_17@yahoo.com.
authors.forename: Suzana
authors.initials: S
authors.lastname: Shahar
authors.affiliation: Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia.
authors.forename: Mohd Azmani
authors.initials: MA
authors.lastname: Sahar
authors.affiliation: Biomedical Science Programme, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia.
authors.forename: Ahmad Rohi
authors.initials: AR
authors.lastname: Ghazali
authors.affiliation: Dietetics Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia.
authors.forename: Zahara Abdul
authors.initials: ZA
authors.lastname: Manaf
authors.affiliation: Institute of Medical Science Technology (UniKL MESTECH), Malaysia.
authors.forename: Rahim Md
authors.initials: RM
authors.lastname: Noah
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D001940:Breast / Q000503:physiopathology*; D031204:Caloric Restriction; D004032:Diet; D015444:Exercise; D005260:Female; D006801:Humans; D008019:Life Style; D008055:Lipids / Q000097:blood; D008296:Malaysia; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology / Q000628:therapy*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids; D020780:Matrix Metalloproteinase 9