title: Photochemistry and pharmacology of 9, 19-cyclolanostane glycosides isolated from genus Cimicifuga.
abstract: The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9, 19-cyclolanostane triterpenoid glycosides, which often exhibit extensive pharmacological activities. 9, 19-Cyclolanostane triterpenoid glycosides are distributed widely in genus Cimicifuga rather than in other members of the Ranunculaceae family. So far, more than 140 cycloartane triterpene glycosides have been isolated from Cimicifuga spp.. The aim of this review was to summarize all 9, 19-cyclolanostane triterpenoid glycosides based on the available relevant scientific literatures from 2000 to 2014. Biological studies of cycloartane triterpene glycosides from Cimicifuga spp. are also discussed.
authors.affiliation: Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90025, USA; Key Laboratory of Chinese Materia Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Su
authors.affiliation: Key Laboratory of Chinese Materia Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
authors.forename: Wen-Cheng
authors.initials: WC
authors.lastname: Chi
authors.affiliation: Key Laboratory of Chinese Materia Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
authors.forename: Lun
authors.initials: L
authors.lastname: Wu
authors.affiliation: Key Laboratory of Chinese Materia Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin 150040, China; The University of Sydney, NSW 2006, Australia.
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Wang
authors.affiliation: Key Laboratory of Chinese Materia Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin 150040, China. Electronic address: suyanggo@hotmail.com.
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Kuang
mesh_terms: D000818:Animals; D031885:Cimicifuga / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D010777:Photochemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D014315:Triterpenes; C085352:cycloartane
keywords: 9, 19-Cyclolanostane glycosides; Biological effects; Chemical structure; Cimicifuga spp.