title: Association between ERCC2 Lys751Gln polymorphism and the risk of pancreatic cancer, especially among Asians: evidence from a meta-analysis.
abstract: Single nucleotide polymorphisms (SNPs) of Excision repair cross-complementing group 2 (ERCC2) gene are suspected to affect the risk of pancreatic cancer. Many studies have reported the association between ERCC2 Lys751Gln polymorphism (rs13181) and the susceptibility to pancreatic cancer, but the outcomes remained controversial. To comprehensively determine this association, we conducted a meta-analysis based on a total of eight studies. Evidence for this association was obtained from the PubMed, EMBASE, Web of Science and Chinese National Knowledge Infrastructure (CNKI) databases. In general, a significant association was found between ERCC2 rs13181 polymorphism and the susceptibility to pancreatic cancer in four genetic models [CC vs. AA: OR = 1.56, (95% CI: 1.28-1.90), P = 0.470; AC/CC vs. AA: OR=1.20, (95% CI: 1.06-1.36), P = 0.396; CC vs.
  OR = 1.50; (95% CI: 1.24-1.81), P = 0.530; C vs. A: OR=1.22, (95%CI:1.11-1.34), P = 0.159]. Furthermore, stratified analyses by ethnicity indicated a significant association only in the Asian population. Our results indicate that the ERCC2 Lys751Gln polymorphism might be important in stimulating the development of pancreatic cancer, especially for Asians.
authors.affiliation: Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.|Pancreas Institute, Nanjing Medical University, Nanjing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.|Pancreas Institute, Nanjing Medical University, Nanjing, China.
authors.forename: Zi-Peng
authors.initials: ZP
authors.lastname: Lu
authors.affiliation: Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.|Pancreas Institute, Nanjing Medical University, Nanjing, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.|Pancreas Institute, Nanjing Medical University, Nanjing, China.
authors.forename: Dong-Fang
authors.initials: DF
authors.lastname: Liu
authors.affiliation: Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.|Pancreas Institute, Nanjing Medical University, Nanjing, China.
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Shi
authors.affiliation: Department of Digestive Diseases, Songjiang Branch Hospital of Shanghai First People's Hospital, Nanjing Medical University, Shanghai, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Qin
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Zhang
authors.affiliation: Pancreas Institute, Nanjing Medical University, Nanjing, China.|Department of Gastrointestinal Surgery, Huai'an Affiliated to Xuzhou Medical University and Huai'an Second People's Hospital, Huai'an, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: He
authors.affiliation: Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.|Pancreas Institute, Nanjing Medical University, Nanjing, China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Wu
authors.affiliation: Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.|Pancreas Institute, Nanjing Medical University, Nanjing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Miao
authors.affiliation: Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.|Pancreas Institute, Nanjing Medical University, Nanjing, China.
authors.forename: Kui-Rong
authors.initials: KR
authors.lastname: Jiang
mesh_terms: D044466:Asian People / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human
keywords: ERCC2; meta-analysis; pancreatic cancer; polymorphism; rs13181