title: Sterols from Thai Marine Sponge Petrosia (Strongylophora) sp. and Their Cytotoxicity.
abstract: Eight new sterols (1-5and11-13), together with eight known compounds (6-10and14-16) were isolated from marine spongePetrosiasp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The cytotoxicity of some compounds against a panel of human cancer cell lines is also reported.
authors.affiliation: Laboratory of Natural Products, Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. pruethai@cri.or.th.
authors.forename: Phanruethai
authors.initials: P
authors.lastname: Pailee
authors.affiliation: Laboratory of Natural Products, Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. mahidol_natlab@cri.or.th.|Chemical Biology Program, Chulabhorn Graduate Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. mahidol_natlab@cri.or.th.
authors.forename: Chulabhorn
authors.initials: C
authors.lastname: Mahidol
authors.affiliation: Laboratory of Natural Products, Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. somsak@cri.or.th.|Chemical Biology Program, Chulabhorn Graduate Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. somsak@cri.or.th.|Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok 10400, Thailand. somsak@cri.or.th.
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
authors.affiliation: Laboratory of Natural Products, Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. vilailak@cri.or.th.
authors.forename: Vilailak
authors.initials: V
authors.lastname: Prachyawarakorn
mesh_terms: D000072283:A549 Cells; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D047130:Petrosia / Q000737:chemistry*; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry* / Q000494:pharmacology*; D013785:Thailand
chemical_list: D000970:Antineoplastic Agents; D013261:Sterols
keywords: Petrosia sp.; cytotoxicity; sterol