title: Is von Willebrand disease linked to cholesteatoma aetiology?
abstract: Cholesteatoma is a common clinical picture seen by otolaryngologists. The disease is characterised by an abnormal grow "of skin in the wrong place". Specifically, in acquired cholesteatoma, the main causative issue is associated with ventilatory deficits within the middle ear and results in chronic infection. Molecular science has associated the presence of specific molecules with its development, and moreover recent research suggests that deregulated angiogenesis is a crucial process in the development of cholesteatoma and its recurrence. Further, haematologists have linked von Willebrand factor and its defects (both quantitative and qualitative) to augmented angiogenesis through upregulation of the vascular endothelial growth factor and angiogenic cytokines. Thus, herewith we probed whether a relationship between von Willebrand disease and the etiopathogenesis of cholesteatoma, plays a potential role for anti-angiogenic molecules for the advent of cholesteatoma surgery adjuvant treatment.
authors.affiliation: Centro Hospitalar do Porto, Largo Prof. Abel Salazar, Porto, Portugal. Electronic address: angelareisrego@gmail.com.
authors.forename: Â
authors.initials: Â
authors.lastname: Reis Rego
authors.affiliation: Centro Hospitalar do Porto, Largo Prof. Abel Salazar, Porto, Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Santos
authors.affiliation: Centro Hospitalar do Porto, Largo Prof. Abel Salazar, Porto, Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Coutinho
authors.affiliation: Centro Hospitalar do Porto, Largo Prof. Abel Salazar, Porto, Portugal.
authors.forename: T
authors.initials: T
authors.lastname: Feliciano
authors.affiliation: Centro Hospitalar do Porto, Largo Prof. Abel Salazar, Porto, Portugal.
authors.forename: C
authors.initials: C
authors.lastname: Almeida E Sousa
mesh_terms: D000293:Adolescent; D000328:Adult; D020533:Angiogenesis Inhibitors / Q000737:chemistry; D002648:Child; D018424:Cholesteatoma, Middle Ear / Q000209:etiology*; D004432:Ear, Middle; D006801:Humans; D007249:Inflammation; D008962:Models, Theoretical; D009389:Neovascularization, Pathologic; D012008:Recurrence; D012867:Skin / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D055815:Young Adult; D014842:von Willebrand Diseases / Q000150:complications*; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D014841:von Willebrand Factor