title: Estimation of cardiovascular risk and detection of subclinical carotid atheromatosis in patients with diabetes without a history of cardiovascular disease.
abstract: OBJECTIVE
  Cardiovascular risk estimated by several scores in patients with diabetes mellitus without a cardiovascular disease history and the association with carotid atherosclerotic plaque (CAP) were the aims of this study.
  
  
  METHODS
  Cardiovascular risk was calculate using United Kingdom Prospective Diabetes Study (UKPDS) risk engine, Framingham risk score for cardiovascular (FSCV) and coronary disease (FSCD), and the new score (NS) proposed by the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol. Ultrasound was used to assess CAP occurrence. A receiver operating characteristic (ROC) analysis was performed.
  
  
  RESULTS
  One hundred seventy patients (mean age 61.4 ± 11 years, 58.8% men) were included. Average FSCV, FSCD and NS values were 33.6% ± 21%, 20.6% ± 12% and 24.8% ± 18%, respectively. According to the UKPDS score, average risk of coronary disease and stroke were 22.1% ± 16% and 14.3% ± 19% respectively. Comparing the risks estimated by the different scores a significant correlation was found. The prevalence of CAP was 51%, in patients with the higher scores this prevalence was increased. ROC analysis showed a good discrimination power between subjects with or without CAP.
  
  
  CONCLUSIONS
  The cardiovascular risk estimated was high but heterogenic. The prevalence of CAP increased according to the strata of risk. Understanding the relationship between CAP and scores could improve the risk estimation in subjects with diabetes.
authors.affiliation: Council of Epidemiology and Cardiovascular Prevention "Dr. Mario Ciruzzi" of the Argentine Society of Cardiology, Buenos Aires, Argentina.
authors.forename: Walter
authors.initials: W
authors.lastname: Masson
authors.affiliation: Council of Epidemiology and Cardiovascular Prevention "Dr. Mario Ciruzzi" of the Argentine Society of Cardiology, Buenos Aires, Argentina.
authors.forename: Salvador De
authors.initials: S
authors.lastname: Francesca
authors.affiliation: Council of Epidemiology and Cardiovascular Prevention "Dr. Mario Ciruzzi" of the Argentine Society of Cardiology, Buenos Aires, Argentina.
authors.forename: Micaela
authors.initials: M
authors.lastname: Molinero
authors.affiliation: Council of Epidemiology and Cardiovascular Prevention "Dr. Mario Ciruzzi" of the Argentine Society of Cardiology, Buenos Aires, Argentina.
authors.forename: Daniel
authors.initials: D
authors.lastname: Siniawski
authors.affiliation: Council of Epidemiology and Cardiovascular Prevention "Dr. Mario Ciruzzi" of the Argentine Society of Cardiology, Buenos Aires, Argentina.
authors.forename: Andrés
authors.initials: A
authors.lastname: Mulassi
authors.affiliation: Council of Epidemiology and Cardiovascular Prevention "Dr. Mario Ciruzzi" of the Argentine Society of Cardiology, Buenos Aires, Argentina.
authors.forename: Frank Espinoza
authors.initials: FE
authors.lastname: Morales
authors.affiliation: Council of Epidemiology and Cardiovascular Prevention "Dr. Mario Ciruzzi" of the Argentine Society of Cardiology, Buenos Aires, Argentina.
authors.forename: Melina
authors.initials: M
authors.lastname: Huerin
authors.affiliation: Council of Epidemiology and Cardiovascular Prevention "Dr. Mario Ciruzzi" of the Argentine Society of Cardiology, Buenos Aires, Argentina.
authors.forename: Martín
authors.initials: M
authors.lastname: Lobo
authors.affiliation: Council of Epidemiology and Cardiovascular Prevention "Dr. Mario Ciruzzi" of the Argentine Society of Cardiology, Buenos Aires, Argentina.
authors.forename: Graciela
authors.initials: G
authors.lastname: Molinero
mesh_terms: D000368:Aged; D001118:Argentina / Q000453:epidemiology; D002340:Carotid Artery Diseases / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000453:epidemiology* / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D015995:Prevalence; D012016:Reference Values; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol