title: Survival assays usingCaenorhabditis elegans.
abstract: Caenorhabditis elegansis an important model organism with many useful features, including rapid development and aging, easy cultivation, and genetic tractability. Survival assays usingC. elegansare powerful methods for studying physiological processes. In this review, we describe diverse types ofC. eleganssurvival assays and discuss the aims, uses, and advantages of specific assays.C. eleganssurvival assays have played key roles in identifying novel genetic factors that regulate many aspects of animal physiology, such as aging and lifespan, stress response, and immunity against pathogens. Because many genetic factors discovered usingC. elegansare evolutionarily conserved, survival assays can provide insights into mechanisms underlying physiological processes in mammals, including humans.
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea.
authors.forename: Hae-Eun H
authors.initials: HH
authors.lastname: Park
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea.
authors.forename: Yoonji
authors.initials: Y
authors.lastname: Jung
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea.|School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 37673, Korea.
authors.forename: Seung-Jae V
authors.initials: SV
authors.lastname: Lee
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology*; D008136:Longevity / Q000235:genetics / Q000502:physiology*; D023421:Models, Animal
keywords: C. elegans; aging; immunity; lifespan; pathogen; stress; survival