title: Involvement of Glycogen Synthase Kinase-3 in the Mechanisms of Conditioned Food Aversion Memory Reconsolidation.
abstract: Experiments were performed on the snails trained in conditioned food aversion for 3 days. Injection of TDZD-8 (glycogen synthase kinase-3 inhibitor, 2 mg/kg) in combination with reminder (presentation of a conditioned food stimulus) led to memory impairment developing 3 days after inhibitor/reminder exposure and followed by spontaneous recovery in 10 days. Injections of TDZD-8 in a dose of 4 or 20 mg/kg before reminder were shown to cause amnesia that persisted for more than 10 days. Memory recovery during repeated training was observed at the earlier period than after initial training. The impairment of memory reconsolidation by TDZD-8 after training of snails for 1 day was less pronounced than under standard training conditions (3 days). The effect of a glycogen synthase kinase-3 inhibitor during memory reconsolidation is probably followed by impairment of memory retrieval and/or partial loss, which can be compensated spontaneously or after repeated training.
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation. nikitin.vp@mail.ru.
authors.forename: V P
authors.initials: VP
authors.lastname: Nikitin
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation.
authors.forename: S V
authors.initials: SV
authors.lastname: Solntseva
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation.
authors.forename: S A
authors.initials: SA
authors.lastname: Kozyrev
mesh_terms: D000647:Amnesia / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics / Q000503:physiopathology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D005786:Gene Expression Regulation; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology; D000069077:Memory Consolidation / Q000187:drug effects* / Q000502:physiology; D057567:Memory, Long-Term / Q000187:drug effects / Q000502:physiology; D013830:Thiadiazoles / Q000494:pharmacology*; D013997:Time Factors
chemical_list: C494356:4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione; D004791:Enzyme Inhibitors; D013830:Thiadiazoles; D038362:Glycogen Synthase Kinase 3
keywords: amnesia; glycogen synthase kinase 3; memory reconsolidation; mollusk