title: Lidocaine/multivalent ion complex as a potential strategy for prolonged local anesthesia.
abstract: Local anesthetics are adopted in clinical practice to manage the perioperative and/or postoperative pain. However, their relatively short duration of action limit their ability to meet clinical needs. Herein, we prepared a lidocaine/multivalent ion complex (icLD) using aqueous solutions containing positively charged LD and a multivalent counter-ion as a system for producing prolonged anesthesia. The results of the in vitro and in vivo experiments indicated that the icLD facilitates prolonged LD release even without adjuvants and thus provides nerve blockade for a long duration of action (∼14h) without further increase in neurotoxicity than the LD itself. These findings suggested that the icLD could be a practical strategy for effectively controlling perioperative and/or postoperative pain in clinical practice.
authors.affiliation: Department of Nanobiomedical Science, Dankook University, Cheonan 31116, Republic of Korea.
authors.forename: You Jin
authors.initials: YJ
authors.lastname: Jang
authors.affiliation: Department of Advanced Materials, Hannam University, Daejeon 34054, Republic of Korea.
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Division of Sports Science and Engineering, Korea Institute of Sport Science, Seoul 01794, Republic of Korea.
authors.forename: Tae Beom
authors.initials: TB
authors.lastname: Seo
authors.affiliation: Department of Nanobiomedical Science, Dankook University, Cheonan 31116, Republic of Korea. Electronic address: seheangoh@dankook.ac.kr.
authors.forename: Se Heang
authors.initials: SH
authors.lastname: Oh
mesh_terms: D000772:Anesthesia, Local / Q000379:methods; D000779:Anesthetics, Local / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000494:pharmacology; D007477:Ions / Q000737:chemistry* / Q000494:pharmacology; D008012:Lidocaine / Q000737:chemistry* / Q000494:pharmacology; D009407:Nerve Block / Q000379:methods; D010149:Postoperative Pain / Q000188:drug therapy; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000779:Anesthetics, Local; D003692:Delayed-Action Preparations; D007477:Ions; D008012:Lidocaine
keywords: Drug delivery system; Ion-complexed drug; Lidocaine; Local anesthetic; Sustained release