title: Cystatin C as a Marker of Progressing Cardiovascular Events during Coronary Heart Disease.
abstract: The role of cystatin C, an inhibitor of cysteine proteases, as an alternative and potent predictor of acute cardiovascular events in coronary heart disease (CHD) patients was examined and compared to that of other markers of cardiorenal abnormalities. The patients with CHD demonstrated elevated serum cystatin C, especially in cases with serious risk of cardiovascular complications. In comparison with other indicators of cardiorenal dysfunction, cystatin C can be viewed as an alternative predictor of cardiovascular complications, although its sensitivity is inferior to that of high-sensitivity C-reactive protein and natriuretic peptide.
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: M M
authors.initials: MM
authors.lastname: Gevorgyan
authors.affiliation: Research Institute of Biochemistry, Novosibirsk, Russia.
authors.forename: N P
authors.initials: NP
authors.lastname: Voronina
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Goncharova
authors.affiliation: Research Institute of Biochemistry, Novosibirsk, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Kozaruk
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: G S
authors.initials: GS
authors.lastname: Russkikh
authors.affiliation: Research Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Bogdanova
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia. t.a.korolenko@physiol.ru.
authors.forename: T A
authors.initials: TA
authors.lastname: Korolenko
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D014508:Urea / Q000097:blood
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D014508:Urea; D002097:C-Reactive Protein; D003404:Creatinine
keywords: biochemical markers; clinical study; coronary heart disease; cystatin C