title: Systemic Amyloidosis Model on Young Mice.
abstract: Subcutaneous daily injection (with neglect of aseptics) of 0.5 ml solution of soybean cream substitute (10% volume in distilled water) during 30 days caused systemic amyloidosis in 30-day-old mice. All the known methods for induction of systemic amyloidosis are based on the use of old animals, as senile tissue bradytrophy allows effective simulation of amyloidosis.
authors.affiliation: Department of Medical Biology with a Course of Microbiology and Virology, Cheboksary, Russia. pooh12@yandex.ru.
authors.forename: V A
authors.initials: VA
authors.lastname: Kozlov
authors.affiliation: Department of Medical Biology with a Course of Microbiology and Virology, Cheboksary, Russia.
authors.forename: S P
authors.initials: SP
authors.lastname: Sapozhnikov
authors.affiliation: Department of Common, Clinical Pathology and Forensic Medicine, I. N. Ulyanov Chuvash State University, Cheboksary, Russia.
authors.forename: P B
authors.initials: PB
authors.lastname: Karyshev
authors.affiliation: Department of Medical Biology with a Course of Microbiology and Virology, Cheboksary, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Sheptukhina
authors.affiliation: Department of Medical Biology with a Course of Microbiology and Virology, Cheboksary, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Nikolaeva
mesh_terms: D017668:Age of Onset; D000682:Amyloid / Q000648:ultrastructure*; D000686:Amyloidosis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D002338:Carotenoids / Q000737:chemistry; D004195:Disease Models, Animal; D045703:Emulsifying Agents / Q000737:chemistry; D066248:High Fructose Corn Syrup / Q000737:chemistry; D007279:Injections, Subcutaneous; D007668:Kidney / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D008099:Liver / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage / Q000633:toxicity*; D012822:Silicon Dioxide / Q000737:chemistry; D063465:Skin Cream / Q000008:administration & dosage / Q000633:toxicity*; D013024:Soybean Oil / Q000737:chemistry; D013154:Spleen / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure
chemical_list: D000682:Amyloid; D045703:Emulsifying Agents; D066248:High Fructose Corn Syrup; D002338:Carotenoids; D012822:Silicon Dioxide; D013024:Soybean Oil
keywords: amyloidosis model; young mice