title: Dengue infection in the nervous system: lessons learned for Zika and Chikungunya.
abstract: Dengue, Zika and Chikungunya are emerging arboviruses and important causes of acute febrile disease in tropical areas. Although dengue does not represent a new condition, a geographic expansion over time has occurred with the appearance of severe neurological complications. Neglect has allowed the propagation of the vector (Aedes spp), which is also responsible for the transmission of other infections such as Zika and Chikungunya throughout the world. The increased number of infected individuals has contributed to the rise of neurological manifestations including encephalitis, myelitis, meningitis, Guillain-Barré syndrome and congenital malformations such as microcephaly. In this narrative review, we characterize the impact of the geographic expansion of the vector on the appearance of neurological complications, and highlight the lack of highly accurate laboratory tests for nervous system infections. This represents a challenge for public health in the world, considering the high number of travelers and people living in endemic areas.
authors.affiliation: Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Escola de Medicina e Cirurgia, Hospital Universitário Gaffree e Guinle, Rio de Janeiro RJ, Brasil.|Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Pós-graduação em Doenças Infecciosas e Parasitárias, Rio de Janeiro RJ, Brasil.
authors.forename: Marzia
authors.initials: M
authors.lastname: Puccioni-Sohler
authors.affiliation: Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Escola de Medicina e Cirurgia, Hospital Universitário Gaffree e Guinle, Rio de Janeiro RJ, Brasil.
authors.forename: Natalia
authors.initials: N
authors.lastname: Roveroni
authors.affiliation: Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Pós-graduação em Doenças Infecciosas e Parasitárias, Rio de Janeiro RJ, Brasil.
authors.forename: Carolina
authors.initials: C
authors.lastname: Rosadas
authors.affiliation: Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Escola de Medicina e Cirurgia, Hospital Universitário Gaffree e Guinle, Rio de Janeiro RJ, Brasil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Ferry
authors.affiliation: Universidade Federal do Rio de Janeiro (UFRJ), Instituto de Microbiologia Professor Paulo de Góes, Rio de Janeiro RJ, Brasil.
authors.forename: Jose Mauro
authors.initials: JM
authors.lastname: Peralta
authors.affiliation: Universidade Federal do Rio de Janeiro (UFRJ), Instituto de Biologia, Rio de Janeiro RJ, Brasil.
authors.forename: Amilcar
authors.initials: A
authors.lastname: Tanuri
mesh_terms: D000818:Animals; D065632:Chikungunya Fever / Q000150:complications* / Q000635:transmission; D003715:Dengue / Q000150:complications* / Q000635:transmission; D006801:Humans; D007303:Insect Vectors / Q000821:virology*; D009422:Nervous System Diseases / Q000821:virology*; D000071243:Zika Virus Infection / Q000150:complications* / Q000635:transmission