title: Copper-Catalyzed Tandem O-Arylation-Oxidative Cross Coupling: Synthesis of Chromone Fused Pyrazoles.
abstract: Intermolecular tandem copper-catalyzed O-arylation-oxidative acylation (cross dehydrogenative coupling-CDC) has been developed under air as an oxidant. The reaction between 2,4-dihydro-3H-pyrazol-3-ones and ortho-halo aryl carboxaldehydes furnished the corresponding chromone fused pyrazoles, in a straightforward manner. The synthetic utility of the presented tandem catalysis has been demonstrated with the synthesis of an A2-subtype selective adenosine receptor antagonist in only two steps.
authors.affiliation: Organic and Biomolecular Chemistry Division, ‡Academy of Scientific and Innovative Research (AcSIR), and §Center for X-ray Crystallography, CSIR-Indian Institute of Chemical Technology (CSIR-IICT) , Hyderabad 500 007, India.
authors.forename: Owk
authors.initials: O
authors.lastname: Obulesu
authors.affiliation: Organic and Biomolecular Chemistry Division, ‡Academy of Scientific and Innovative Research (AcSIR), and §Center for X-ray Crystallography, CSIR-Indian Institute of Chemical Technology (CSIR-IICT) , Hyderabad 500 007, India.
authors.forename: K Harish
authors.initials: KH
authors.lastname: Babu
authors.affiliation: Organic and Biomolecular Chemistry Division, ‡Academy of Scientific and Innovative Research (AcSIR), and §Center for X-ray Crystallography, CSIR-Indian Institute of Chemical Technology (CSIR-IICT) , Hyderabad 500 007, India.
authors.forename: Jagadeesh Babu
authors.initials: JB
authors.lastname: Nanubolu
authors.affiliation: Organic and Biomolecular Chemistry Division, ‡Academy of Scientific and Innovative Research (AcSIR), and §Center for X-ray Crystallography, CSIR-Indian Institute of Chemical Technology (CSIR-IICT) , Hyderabad 500 007, India.
authors.forename: Surisetti
authors.identifier: 0000-0003-0202-5781
authors.initials: S
authors.lastname: Suresh