title: New Connections: Cell-to-Cell HIV-1 Transmission, Resistance to Broadly Neutralizing Antibodies, and an Envelope Sorting Motif.
abstract: HIV-1 infection from cell-to-cell may provide an efficient mode of viral spreadin vivoand could therefore present a significant challenge for preventative or therapeutic strategies based on broadly neutralizing antibodies. Indeed, Li et al. (H. Li, C. Zony, P. Chen, and B. K. Chen, J. Virol. 91:e02425-16, 2017, https://doi.org/10.1128/JVI.02425-16) showed that the potency and magnitude of multiple HIV-1 broadly neutralizing antibody classes are decreased during cell-to-cell infection in a context-dependent manner. A functional motif in gp41 appears to contribute to this differential susceptibility by modulating exposure of neutralization epitopes.
authors.affiliation: Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.|Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.
authors.forename: S Abigail
authors.initials: SA
authors.lastname: Smith
authors.affiliation: Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA cderdey@emory.edu.|Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.|Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Derdeyn
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D015483:HIV Antibodies / Q000276:immunology*; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015700:HIV Envelope Protein gp41 / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D000939:Epitopes; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41; C514787:gp41 protein, Human immunodeficiency virus 1
keywords: broadly neutralizing antibody; human immunodeficiency virus; viral envelope; virological synapse