title: Effects of Six Weeks Endurance Training and Aloe Vera Supplementation on COX-2 and VEGF Levels in Mice with Breast Cancer
abstract: The aim of this study was to determine effects of six weeks endurance training and Aloe Vera supplementation on
  COX-2 and VEGF levels in mice with breast cancer. For this purpose, 35 rats were randomly divided into 5 groups:
  control (healthy) and 4 cancer groups: control (cancer only), training, Aloe Vera and Aloe Vera + training. Breast
  cancer tumors were generated in mice by implantind. The training program comprised six weeks of swimming training
  accomplished in three sessions per week. Training time started with 10 minutes on the first day and increased to 60
  minutes in the second week and the water flow rate was increased from 7 to 15 liters per minute at a constant rate. Aloe
  Vera extract at a dose of 300 mg/kg BW was administrated to rats by intraperitoneal injection. At the end of the study
  period, rats were anesthetized and blood samples were taken. Significant differences were concluded at p<0.05 with
  Kolmogorov-Smirnov and Tukey tests to analyze the data. The results showed significant increase in levels of serum.
  COX-2 and VEGF levels in the cancer group compared with the healthy group. Administration of Aloe Vera extract
  caused significant decrease in the COX-2 level in the cancer group. Also, in the training (swimming exercise) and
  Aloe Vera + training cancer groups, we observed significant decrease in the VEGF level as compared to controls. Our
  results suggest that Aloe Vera and training inhibit the COX pathway and cause decrease production of prostaglandin
  E2. Hence administration of Aloe Vera in combination with endurance training might synergistically improve the host
  milieu in mice bearing breast cancers.
authors.affiliation: Research Center of Thalassemia and Hemoglobinopathy, Department of Laboratory Sciences, School of Paramedical Sciences, Ayatollah Amoli Branch, Islamic Azad University, Amol|Student Research Committee,  Ayatollah Amoli Branch, Islamic Azad University, Amol. Email:alireza54.barari@gmail.com
authors.forename: Saeed
authors.initials: S
authors.lastname: Shirali
authors.forename: Alireza
authors.initials: A
authors.lastname: Barari
authors.forename: Seyed Ahmad
authors.initials: SA
authors.lastname: Hosseini
authors.forename: Elaheh
authors.initials: E
authors.lastname: Khodadi
keywords: Training; Aloe Vera extract; COX-2; VEGF; Breast cancer