title: Human exposure to perfluoroalkyl substances near a fluorochemical industrial park in China.
abstract: Severe perfluoroalkyl substance (PFAS) contaminations have been observed in both surface water and groundwater in the vicinity of Fuxin, China, over the past years, attributing to the fast-growing fluorochemical industries locally. However, little is known about the overall daily intake of PFAS contaminations by Fuxin residents recently. In the present study, ten target PFAS analytes in the blood serum samples collected from 100 non-occupationally exposed healthy residents in Fuxin, with an average age of 47.6 years, together with 14 drinking water samples obtained from the public water system (PWS) of Fuxin were analyzed via high-performance liquid chromotography-tandem mass spectrometry (HPLC-MS/MS). As the dominant PFAS contaminant, the serum concentrations of perfluorooctanoic acid (PFOA) in Fuxin residents ranged between <0.05 and 160 ng/mL, with a median concentration of 9.4 ng/mL, which was higher than those reported previously for Fuxin and other areas worldwide. In drinking water samples, PFOA had a median value of 8.5 ng/L, ranging from 7.7 to 8.8 ng/L. Based upon the simplified one-compartment pharmacokinetic model, the total daily intake of PFOA for individuals residing in Fuxin ranged from 0.30 to 1.76 ng/kg bw/day, with a median of 0.79 ng/kg bw/day; furthermore, daily consumption of drinking water from the PWS in Fuxin appeared to contribute 35% of overall PFOA burden in local residents, which was approximately 3-fold higher compared to that estimated for Fuxin residents in 2009.
authors.affiliation: School of Science, Shenyang University of Technology, Shenyang, 110870, China. baojia@sut.edu.cn.
authors.forename: Jia
authors.initials: J
authors.lastname: Bao
authors.affiliation: Department of Social Medicine, School of Public Health, China Medical University, Shenyang, 110122, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Science, Shenyang University of Technology, Shenyang, 110870, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Dalian, 116024, China.
authors.forename: Yi-He
authors.initials: YH
authors.lastname: Jin
authors.affiliation: Department of Preventive Medicine, School of Public Health, Sun Yat-Sen University, Guangzhou, 510080, China.
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Dong
mesh_terms: D017738:Alkanesulfonic Acids; D002210:Caprylates; D002681:China; D060766:Drinking Water / Q000737:chemistry; D005466:Fluorocarbons; D006801:Humans; D053719:Tandem Mass Spectrometry; D014874:Water Pollutants, Chemical
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D060766:Drinking Water; D005466:Fluorocarbons; D014874:Water Pollutants, Chemical
keywords: Daily intake; Drinking water; Human blood serum; Perfluoroalkyl substance (PFAS); Perfluorooctanoic acid (PFOA)