title: Interleukin-10: A Compelling Therapeutic Target in Patients With Irritable Bowel Syndrome.
abstract: OBJECTIVE
  Pro- and antiinflammatory cytokines are important modulators of the immune response and play a major role in conditions of intestinal inflammation, such as irritable bowel syndrome (IBS). Cytokine production is regulated genetically, and imbalances in cytokine secretion may affect disease susceptibility and clinical outcomes of various conditions. There is a rapidly growing body of evidence to support an etiologic role for gastrointestinal infection and the associated immune activation in the development of postinfectious IBS. Other factors such as psychological stress, anxiety, and depression may likely be involved in the altered profiles of pro- and antiinflammatory cytokines that lead to chronic IBS.
  
  
  METHODS
  We searched the literature using PubMed, MEDLINE, and Google Scholar with related key terms and prepared this review article on that basis.
  
  
  RESULTS
  Interleukin (IL)-10 is a regulatory cytokine that inhibits both antigen presentation and the release of proinflammatory cytokines. Therefore, it is proposed as a potent antiinflammatory biological therapy for IBS.
  
  
  CONCLUSIONS
  Recently, a strong interest in the therapeutic potential of IL-10 for IBS has developed. The diverse roles of IL-10 in IBS are reviewed here. We conducted an in-depth review on IL-10 and IBS to address this question. Future studies of IL-10 may provide new insights into IBS therapy.
authors.affiliation: Faculty of Biotechnology, Institute of Bioscience and Technology, Shri Ramswaroop Memorial University, Barabanki, India. Electronic address: sunil.bio@srmu.ac.in.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
authors.forename: Ratnakar
authors.initials: R
authors.lastname: Shukla
authors.affiliation: Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
authors.forename: Prabhat
authors.initials: P
authors.lastname: Ranjan
authors.affiliation: Department of Biotechnology, National Institute of Technology, Raipur, India. Electronic address: awanik.bt@nitrr.ac.in.
authors.forename: Awanish
authors.initials: A
authors.lastname: Kumar
mesh_terms: D001007:Anxiety / Q000150:complications; D016207:Cytokines / Q000378:metabolism*; D003863:Depression / Q000150:complications; D006801:Humans; D007249:Inflammation / Q000276:immunology; D016753:Interleukin-10 / Q000378:metabolism*; D043183:Irritable Bowel Syndrome / Q000276:immunology*
chemical_list: D016207:Cytokines; C508609:IL10 protein, human; D016753:Interleukin-10
keywords: IL-10; cytokines; inflammation; inflammatory bowel disease; therapy