title: Body mass index (BMI) may be a prognostic factor for gastric cancer with peritoneal dissemination.
abstract: BACKGROUND
  The aim of this study is to investigate whether body mass index (BMI) is a prognostic factor in gastric cancer patients with peritoneal dissemination.
  
  
  METHODS
  This is a retrospective study consisting of 518 patients with a histological diagnosis of gastric cancer with peritoneal dissemination seen at the Sixth Affiliated Hospital of Sun Yat-Sen University and Sun Yat-sen University Cancer Center between January 2010 and April 2014. Patients were followed until December 2015. Chi-square test and Kaplan-Meier survival analysis were used to compare the clinicopathological variables and prognosis.
  
  
  RESULTS
  Univariate analyses showed that significant prognostic factors included palliative gastrectomy (p < 0.001), tumor size (p < 0.001), tumor location (p = 0.011), peritoneal seeding grade (p < 0.001), ascites (p = 0.001), serum CEA level (p = 0.002), serum CA19-9 level (p = 0.033), palliative chemotherapy (p < 0.001), and BMI group (p < 0.001). For patients with palliative chemotherapy, univariate analysis revealed that palliative gastrectomy (p < 0.001), tumor size (p = 0.002), tumor location (p = 0.024), peritoneal seeding grade (p = 0.008), serum CEA level (p = 0.041), and BMI group (p < 0.001). Multivariate analysis revealed that BMI was an independent prognostic factor in gastric cancer patients with peritoneal dissemination, especially in patients who received palliative chemotherapy.
  
  
  CONCLUSIONS
  BMI is a prognostic factor for patients who have gastric cancer with peritoneal dissemination, especially in those who received palliative chemotherapy.
authors.affiliation: The 6th Affiliated Hospital, Sun Yat-Sen University, No. 26, YuanCun ErHeng Road, TianHe District, 510655, Guangzhou, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Gastropancreatic Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, 510060, Guangzhou, China.
authors.forename: Run-Cong
authors.initials: RC
authors.lastname: Nie
authors.affiliation: Department of Intensive Care Unit, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, 510060, Guangzhou, China.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: OuYang
authors.affiliation: Department of Gastropancreatic Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, 510060, Guangzhou, China.
authors.forename: Yuan-Fang
authors.initials: YF
authors.lastname: Li
authors.affiliation: The 6th Affiliated Hospital, Sun Yat-Sen University, No. 26, YuanCun ErHeng Road, TianHe District, 510655, Guangzhou, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xiang
authors.affiliation: Department of Gastropancreatic Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, 510060, Guangzhou, China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Zhou
authors.affiliation: Department of Gastropancreatic Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, 510060, Guangzhou, China. chenyb@sysucc.org.cn.
authors.forename: YingBo
authors.initials: Y
authors.lastname: Chen
authors.affiliation: The 6th Affiliated Hospital, Sun Yat-Sen University, No. 26, YuanCun ErHeng Road, TianHe District, 510655, Guangzhou, China. pengjunsheng@tom.com.
authors.forename: JunSheng
authors.initials: J
authors.lastname: Peng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000556:secondary* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology* / Q000628:therapy; D015996:Survival Rate; D055815:Young Adult
keywords: BMI; Gastric cancer; Palliative chemotherapy; Peritoneal dissemination; Prognosis