title: The Coordination Abilities of New Cyclic Analogs of Somatostatin.
abstract: Two new somatostatin analogs with a characteristic part of the sequence -c(Cys-Phe-Trp-Lys-Thr-Cys)- and with two histidine and two aspartic acid moieties in their structures were synthesized and analyzed in terms of their coordination abilities with copper (II) ions. Both peptides bind Cu(II) effectively. Ligands form 4N complexes with [Formula: see text] binding mode in a basic range of pH. But in spite of very similar sequences of the two peptides a significant difference in the effectiveness of the binding of copper (II) ions was observed.
authors.affiliation: Department of Inorganic Chemistry, Wroclaw Medical University, Borowska 211A, 50-556 Wrocław, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Marciniak
authors.affiliation: Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wrocław, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Cebrat
authors.affiliation: Department of Inorganic Chemistry, Wroclaw Medical University, Borowska 211A, 50-556 Wrocław, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Brasuń
keywords: Copper complexes; Potentiometric measurements; Somatostatin; Somatostatin analogs; Spectroscopy