title: Correlations between lncRNA-SOX2OT polymorphism and susceptibility to breast cancer in a Chinese population.
abstract: OBJECTIVE
  We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study.
  
  
  METHODS
  A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues' SOX2OT expression. Genotyping of rs9839776 were conducted by using SNaPshot assays.
  
  
  RESULTS
  SOX2OT were overexpressed in BC tissues (p < 0.001). SOX2OT SNP rs9839776 was strongly associated with the higher expression of SOX2OT and an increased risk of BC in Chinese women (odds ratio: 1.42; 95% CI: 1.06-1.90; p = 0.018).
  
  
  CONCLUSIONS
  These results confirmed that BC was conspicuously associated with higher SOX2OT expression. SOX2OT SNP rs9839776 was significantly associated with the onset of BC possibly via influencing the expression of SOX2OT.
authors.affiliation: Department of Gynecology & Obstetrics, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Xiuwu
authors.initials: X
authors.lastname: Tang
authors.affiliation: Institute of Suzhou Biobank, Suzhou Center for Disease Prevention & Control, Suzhou, Jiangsu, China.|Department of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control & Prevention, Nanjing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Cardiothoracic Surgery, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China.
authors.forename: Linxiang
authors.initials: L
authors.lastname: Yu
authors.affiliation: Institute of Suzhou Biobank, Suzhou Center for Disease Prevention & Control, Suzhou, Jiangsu, China.|Department of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control & Prevention, Nanjing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Third Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment & Research center, Tianjin Medical University Institute & Hospital, National Clinical Research Center of Cancer, Tianjin, China.
authors.forename: Guanglin
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Department of Pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Lifang
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Emergency, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.affiliation: Department of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control & Prevention, Nanjing, China.
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Department of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control & Prevention, Nanjing, China.|Department of Pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.affiliation: Third Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment & Research center, Tianjin Medical University Institute & Hospital, National Clinical Research Center of Cancer, Tianjin, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D002681:China; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding / Q000235:genetics*; D012306:Risk
chemical_list: D062085:RNA, Long Noncoding; C000610979:long non-coding RNA Sox2ot, human
keywords: SOX2OT; breast cancer; long noncoding RNA; polymorphism