title: [Coexpression of MAP2K4 and vimentin proteins in human endometrial carcinoma and its clinicopathological significance].
abstract: OBJECTIVE
  To analyze the expression of MAP2K4 and vimentin in human endometrial carcinoma (EC) and their association with the clinicopathological features and prognosis of the patients.
  
  
  METHODS
  MAP2K4 and vimentin expressions were detected immunohistochemically in paraffin-embedded tissue sections from 128 patients with EC, and the correlation of MAP2K4 and vimentin expressions with the clinicopathological factors of the patients was analyzed.
  
  
  RESULTS
  MAP2K4 and vimentin proteins were positively expressed in 49 (38.3%) and 83 (64.8%) of the patients, respectively. A positive expression of MAP2K4 was negatively correlated with FIGO stage of the tumor (P=0.010) and lymph node status (P=0.016); a positive expression of vimentin was positively correlated with FIGO stage of the tumor (P=0.025), histological grades (P=0.017), depth of myometrial invasion (P=0.044) and lymph node status (P=0.032). MAP2K4 was inversely associated with vimentin expression in EC(r=-0.598, P<0.001). Patients positive for MAP2K4 tended to have a higher overall survival rate (P=0.002), and those positive for vimentin tended to have a lower overall survival rate (P=0.007); patients positive for MAP2K4 but negative for vimentin had the longest survival time, while those negative for MAP2K4 and positive for vimentin had lowest survival rate (P=0.004).
  
  
  CONCLUSIONS
  Detection of MAP2K4 and vimentin might help in early diagnosis and prognostic evaluation of patients with EC.
authors.affiliation: Department of Obstetrics and Gynecology, Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, China. E-mail: 838240067@qq.com.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Liu
authors.forename: Qing-Ping
authors.initials: QP
authors.lastname: Jiang
authors.forename: Dan
authors.initials: D
authors.lastname: Lin
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Yan-Yi
authors.initials: YY
authors.lastname: Xiao
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Yuan-Run
authors.initials: YR
authors.lastname: Deng
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Jiang
authors.forename: Sui-Qun
authors.initials: SQ
authors.lastname: Guo
mesh_terms: D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D048670:MAP Kinase Kinase 4 / Q000378:metabolism*; D011379:Prognosis; D015996:Survival Rate; D014746:Vimentin / Q000378:metabolism*
chemical_list: D014746:Vimentin; D048670:MAP Kinase Kinase 4; C482559:MAP2K4 protein, human