title: Recognition and tethering of transport vesicles at the Golgi apparatus.
abstract: The Golgi apparatus occupies a central position within the secretory pathway where it is a hub for vesicle trafficking. Distinct classes of transport vesicles traffic diverse cargoes into and out of this organelle, as well as between the different Golgi subcompartments. A key feature of Golgi trafficking is the specific recognition of transport vesicles at the different regions of the Golgi apparatus, required for the correct cargo delivery. Specificity is ensured by coiled-coil golgins and multi-subunit tethering complexes (MTCs), which act together to capture vesicles and promote their subsequent fusion with the Golgi membrane. In this review we discuss our current understanding of how golgins and MTCs function together to mediate the specific recognition of vesicles at the Golgi apparatus.
authors.affiliation: Faculty of Biology, Medicine and Health, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Tomasz M
authors.initials: TM
authors.lastname: Witkos
authors.affiliation: Faculty of Biology, Medicine and Health, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK. Electronic address: martin.lowe@manchester.ac.uk.
authors.forename: Martin
authors.initials: M
authors.lastname: Lowe
mesh_terms: D000818:Animals; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D050576:Membrane Fusion Proteins / Q000378:metabolism; D021381:Protein Transport; D055571:Secretory Pathway; D022161:Transport Vesicles / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism
chemical_list: D050576:Membrane Fusion Proteins; D033921:Vesicular Transport Proteins