title: Toxicity Research of PM2.5Compositions In Vitro.
abstract: According to the published literature, we surmise that particulate matter (PM) concentration, individually, may be less important than components in explaining health effects. PM2.5(aerodynamic diameter <2.5 μm) had similar cytotoxicity (e.g., cell viability reduction, oxidative damage, inflammatory effects and genetic toxicity) on different types of cells. The studies of cells are readily available for detailed mechanistic investigations, which is more appropriate for learning and comparing the mechanism caused by single or mixed ingredients coating a carbon core. No review exists that holistically examines the evidence from all components-based in vitro studies. We reviewed published studies that focus on the cytotoxicity of normal PM2.5. Those studies suggested that the toxicity of mixed compositions differs greatly from the single ingredients in mixed components and the target cells. The cytotoxic responses caused by PM2.5components have not shown a consistent association with clear, specific health effects. The results may be beneficial for providing new targets for drugs for the treatment of PM2.5-related diseases.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China. jiayy14@mails.jlu.edu.cn.
authors.forename: Yi-Yang
authors.initials: YY
authors.lastname: Jia
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China. wangqi15@mails.jlu.edu.cn.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130033, China. iamliute@126.com.
authors.forename: Te
authors.initials: T
authors.lastname: Liu
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D010316:Particle Size; D052638:Particulate Matter / Q000633:toxicity*; D018675:Toxicity Tests / Q000379:methods
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter
keywords: cell; components; health; particular matter; toxicology