title: 18F-FDG PET/CT/MRI Fusion Images Showing Cranial and Peripheral Nerve Involvement in Neurolymphomatosis.
abstract: We report a 56-year-old female patient with non-Hodgkin's diffuse large B cell lymphoma (NHL) who, on magnetic resonance imaging (MRI) with a T1 weighted and gadolinium-enhanced imaging, was found to have thickening and infiltration in 75% of peripheral nerves of the patient and enlargements of cranial nerves, possibly related to lymphomatous infiltration. Subsequent positron emission tomography/computed tomography (PET/CT) using18F-labeled 2-deoxy-2-fluoro-d-glucose (18F-FDG) showed widespread active involvement of the cervical plexus, bilateral peripheral nerves, right femoral nerve, the parasellar region of the skull, and marked hypermetabolism in the left trigeminal ganglia. This case re-emphasizes that while CT and MRI provide anatomical details,18F-FDG PET/CT images better delineate the metabolic activity of neurolymphomatosis (NL) in the peripheral and central nervous system.
authors.affiliation: Nuclear Medicine and Molecular Imaging Section, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil; Bioengineering Interunits Postgraduation Program, São Carlos School of Engineering, University of São Paulo, São Carlos, Brazil.
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Trevisan
authors.affiliation: Division of Hematology of the Internal Medicine Department and Postgraduation Program. Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Fernanda Borges
authors.initials: FB
authors.lastname: Ribeiro
authors.affiliation: Nuclear Medicine and Molecular Imaging Section, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil; Bioengineering Interunits Postgraduation Program, São Carlos School of Engineering, University of São Paulo, São Carlos, Brazil.
authors.forename: Emerson Nobuyuki
authors.initials: EN
authors.lastname: Itikawa
authors.affiliation: Nuclear Medicine and Molecular Imaging Section, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Leonardo Santos
authors.initials: LS
authors.lastname: Alexandre
authors.affiliation: Nuclear Medicine and Molecular Imaging Section, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Felipe Arriva
authors.initials: FA
authors.lastname: Pitella
authors.affiliation: Nuclear Medicine and Molecular Imaging Section, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Santos
authors.affiliation: Division of Hematology of the Internal Medicine Department and Postgraduation Program. Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Belinda Pinto
authors.initials: BP
authors.lastname: Simões
authors.affiliation: Nuclear Medicine and Molecular Imaging Section, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil; Bioengineering Interunits Postgraduation Program, São Carlos School of Engineering, University of São Paulo, São Carlos, Brazil.
authors.forename: Lauro
authors.initials: L
authors.lastname: Wichert-Ana
keywords: 18F-FDG; PET/CT; neurolymphomatosis; non-Hodgkin lymphoma