title: [Acute generalized exanthematous pustulosis induced by phloroglucinol].
abstract: BACKGROUND
  Acute generalized exanthematous pustulosis (AGEP) is a severe drug eruption. We report herein the first case of AGEP induced by phloroglucinol (Spasfon®).
  
  
  METHODS
  A 27-year-old pregnant woman developed a febrile exanthematous pustulosis eruption three days after treatment with intravenous phloroglucinol and paracetamol for nephritic colic. She had no previous history of psoriasis. The laboratory workup showed hyperleukocytosis with neutrophilia. A cytobacteriological sample of the pustules was negative. Skin biopsy revealed marked neutrophilic and leukocytoclastic vasculitis. Reintroduction of phloroglucinol after delivery resulted in the same clinical symptoms within a few hours of intake. A diagnosis of phloroglucinol-induced AGEP was made on the basis of intrinsic imputability of I4 (S3 C3) using the imputability criteria of Begaud et al. The outcome was favorable after withdrawal of the drug.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first case of phloroglucinol-induced AGEP confirmed by reintroduction of the drug.
authors.affiliation: Service de dermatologie, hôpital Bichat, université Denis-Diderot, Sorbonne Paris Cité, AP-HP, 46, rue Henri-Huchard, 75877 Paris cedex 18, France. Electronic address: nesrine.brahimi@bch.aphp.fr.
authors.forename: N
authors.initials: N
authors.lastname: Brahimi
authors.affiliation: Service de dermatologie, hôpital Avicenne, université Paris 13, AP-HP, 125, rue de Stalingrad, 93000 Bobigny, France.
authors.forename: E
authors.initials: E
authors.lastname: Maubec
authors.affiliation: Service d'anatomie pathologique, hôpital Bichat, université Denis-Diderot, Sorbonne Paris Cité, AP-HP, 46, rue Henri-Huchard, 75877 Paris cedex 18, France.
authors.forename: T
authors.initials: T
authors.lastname: Petit
authors.affiliation: Service de dermatologie, hôpital Bichat, université Denis-Diderot, Sorbonne Paris Cité, AP-HP, 46, rue Henri-Huchard, 75877 Paris cedex 18, France.
authors.forename: B
authors.initials: B
authors.lastname: Crickx
authors.affiliation: Service de dermatologie, hôpital Bichat, université Denis-Diderot, Sorbonne Paris Cité, AP-HP, 46, rue Henri-Huchard, 75877 Paris cedex 18, France.
authors.forename: V
authors.initials: V
authors.lastname: Descamps
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage; D056150:Acute Generalized Exanthematous Pustulosis / Q000175:diagnosis* / Q000209:etiology*; D058633:Antipyretics / Q000008:administration & dosage; D001706:Biopsy; D005260:Female; D006801:Humans; D007202:Indicators and Reagents / Q000009:adverse effects*; D010696:Phloroglucinol / Q000009:adverse effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000209:etiology*; D056844:Renal Colic / Q000188:drug therapy; D012867:Skin / Q000473:pathology
chemical_list: D058633:Antipyretics; D007202:Indicators and Reagents; D000082:Acetaminophen; D010696:Phloroglucinol
keywords: Acute generalized exanthematous pustulosis; Grossesse; Phloroglucinol; Pregnancy; Pustulose exanthématique aiguë généralisée