title: Interaction of Gender and Hepatitis C in Risk of Chronic Renal Failure After Liver Transplantation.
abstract: Chronic renal failure (CRF) is a significant cause of morbidity and mortality in post-liver transplantation (LT) recipients. The risk factors associated with the development of renal dysfunction are not clearly elucidated.
  
  
  
  To examine the risk factors in the development of CRF in these patients.
  
  
  
  Retrospective case-cohort of liver transplant patients without baseline kidney dysfunction who developed chronic renal failure during their follow-up.
  
  
  
  Of 370 patients, 254 met the inclusion criteria. 30% (76) of these patients had CRF of which 57% (43) were male. Age, estimated glomerular filtration rate (eGFR) at discharge, and HCV infection were found to be risk factors for CRF post-LT. The odds ratio of developing CRF was 1.4 (0.6-3.3) in males with HCV, 1.6 (0.7-3.9) in females without HCV and 4.4 (1.5-13.2) among females with HCV when compared to men without HCV.
  
  
  
  In this cohort of LT receipients of a major Canadian city, age, eGFR, and HCV infection were risk factors for CRF. Female gender and HCV increased this odds by a factor of more than 4.
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Stephen
authors.initials: S
authors.lastname: Ip
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Trana
authors.initials: T
authors.lastname: Hussaini
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Aliya
authors.initials: A
authors.lastname: Daulat
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Nilufar
authors.initials: N
authors.lastname: Partovi
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Siegfried R
authors.initials: SR
authors.lastname: Erb
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Yoshida
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Marquez
mesh_terms: D000328:Adult; D000368:Aged; D001955:British Columbia; D016009:Chi-Square Distribution; D005260:Female; D005919:Glomerular Filtration Rate; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016031:Liver Transplantation / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: Kidney Failure; Liver Transplant; Prognosis; calcineurin inhibitors; gender