title: Captopril does not Potentiate Post-Exercise Hypotension: A Randomized Crossover Study.
abstract: To evaluate whether captopril (3×50 mg/day) potentiates post-resistance exercise hypotension (PREH) in hypertensives (HT), 12 HT men received captopril and placebo for 4 weeks each in a double-blinded, randomized-crossover design. On each therapy, subjects underwent 2 sessions: Control (C - rest) and Resistance Exercise (RE - 7 exercises, 3 sets to moderate fatigue, 50% of 1 RM -repetition maximum). Measurements were taken before and after 30-60 min (Post1) and 7 h (Post2), and ambulatory blood pressure (BP) was monitored for 24 h. There were no differences in PREH characteristics and mechanisms between the placebo and captopril periods. At Post1, systolic/diastolic BP decreased significantly and similarly after RE with both therapies (Placebo=-13±2/-9±1 mmHg vs. Captopril=-12±2/-10±1 mmHg, P<0.05). RE reduced cardiac output in some subjects and systemic vascular resistance in others. Heart rate and cardiac sympathetic modulation increased, while stroke volume and baroreflex sensitivity decreased after RE (Placebo: +13±2 bpm, +21±5 nu, -11±5 ml, -4±2 ms/mmHg; Captopril: +13±2 bpm, +35±4 nu, 17±5 ml, -3±1 ms/mmHg, P<0.05). At Post2, all variables returned to pre-intervention values. Ambulatory BP was similar between the sessions. Thus, captopril did not potentiate the magnitude and duration of PREH in HT men, and it did not influence PREH mechanisms.
authors.affiliation: School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
authors.forename: Andréia Cristiane Carrenho
authors.initials: AC
authors.lastname: Queiroz
authors.affiliation: School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
authors.forename: Julio Cesar Silva
authors.initials: JC
authors.lastname: Sousa
authors.affiliation: School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
authors.forename: Natan Daniel
authors.initials: ND
authors.lastname: Silva
authors.affiliation: Department of Biomedical and Clinical Sciences "L. Sacco", Medicine and Physiopathology, L. Sacco Hospital, University of Milan, Milan, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Tobaldini
authors.affiliation: General Hospital, University of São Paulo, São Paulo, Brazil.
authors.forename: Katia Coelho
authors.initials: KC
authors.lastname: Ortega
authors.affiliation: School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
authors.forename: Edilamar Menezes
authors.initials: EM
authors.lastname: de Oliveira
authors.affiliation: School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
authors.forename: Patricia Chakur
authors.initials: PC
authors.lastname: Brum
authors.affiliation: Department of Biomedical and Clinical Sciences "L. Sacco", Medicine and Physiopathology, L. Sacco Hospital, University of Milan, Milan, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Montano
authors.affiliation: General Hospital, University of São Paulo, São Paulo, Brazil.
authors.forename: Decio
authors.initials: D
authors.lastname: Mion
authors.affiliation: School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
authors.forename: Taís
authors.initials: T
authors.lastname: Tinucci
authors.affiliation: School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil.
authors.forename: Claudia Lucia
authors.initials: CL
authors.lastname: de Moraes Forjaz
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage; D001794:Blood Pressure; D002216:Captopril / Q000008:administration & dosage*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D057774:Post-Exercise Hypotension / Q000188:drug therapy*; D055070:Resistance Training; D013318:Stroke Volume; D014655:Vascular Resistance
chemical_list: D000959:Antihypertensive Agents; D002216:Captopril