title: Low-dose prednisone and immunoglobulin G treatment for woman at risk for neonatal alloimmune thrombocytopenia and T helper 1 immunity.
abstract: Fetal and neonatal alloimmune thrombocytopenia is an alloimmune disorder resulting from platelet opsonization by maternal antibodies that destroy fetal platelets. As there is no antenatal screening or immunization to prevent sensitization, selection of high-risk population or the prevention of antenatal sensitization is significantly limited.
  
  
  
  (i) A case report of ante- and postnatal management of a woman with paternal homozygosity for human platelet antigen-1(HPA) incompatibility. (ii) A retrospective case-control study of 11 confirmed FNAIT patients, 8 possible-FNAIT women, and 10 women with confirmed ITP.
  
  
  
  Antenatal screening, prevention of maternal sensitization by serial monitoring and immunosuppression with prednisone and intravenous immunoglobulin G (IVIG) infusion resulted in two successful pregnancies without sensitization.
  
  
  
  Screening for couples at risk and prednisone and/or IVIG treatment is an option for women with paternal homozygosity for offending HPA antigen to prevent antenatal sensitization. HPA incompatibility is associated with increased Th1 immunity and NK cell cytotoxicity.
authors.affiliation: Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA.
authors.forename: Annie
authors.identifier: 0000-0003-3643-4882
authors.initials: A
authors.lastname: Skariah
authors.affiliation: Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA.
authors.forename: Nayoung
authors.initials: N
authors.lastname: Sung
authors.affiliation: Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA.
authors.forename: Maria D
authors.initials: MD
authors.lastname: Salazar Garcia
authors.affiliation: Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Microbiology and Immunology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
authors.forename: Anjali
authors.initials: A
authors.lastname: Tikoo
authors.affiliation: Department of Microbiology and Immunology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
authors.forename: Alice
authors.initials: A
authors.lastname: Gilman-Sachs
authors.affiliation: Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA.|Department of Microbiology and Immunology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
authors.forename: Joanne
authors.initials: J
authors.lastname: Kwak-Kim
mesh_terms: D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D011241:Prednisone / Q000627:therapeutic use*; D011247:Pregnancy; D012306:Risk; D018417:Th1 Cells / Q000276:immunology; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000517:prevention & control*
chemical_list: D016824:Antigens, Human Platelet; D007074:Immunoglobulin G; D011241:Prednisone
keywords: T helper cells; alloantibody; neonatal alloimmune thrombocytopenia; prednisone; prenatal diagnosis