title: The effects of unilateral cochlear ablation on the expression of vesicular glutamate transporter 1 in the lower auditory pathway of neonatal rats.
abstract: OBJECTIVE
  Unilateral cochlear damage has profound effects on the central auditory pathways in the brain.
  
  
  METHODS
  We examined the effects of unilateral cochlear ablation on VGLUT1 expression in the cochlear nucleus (CN) and the superior olivary complex (SOC) in neonatal rats.
  
  
  RESULTS
  VGLUT1 expression in the CN subdivisions (the AVCN, the PVCN and the DCN-deep layers) and the SOC (the MnTB, the LSO and the MSO) ipsilateral to the ablated side was significantly suppressed by unilateral cochlear ablation. Interestingly, VGLUT1 expression in the PVCN and the DCN-deep layers contralateral to the ablated side was also reduced.
  
  
  CONCLUSIONS
  Our findings indicate that unilateral cochlear ablation affects VGLUT1 expression in the central auditory pathways not only ipsilateral but also contralateral to the ablated side.
authors.affiliation: Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan; Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan; Department of Otolaryngology-Head and Neck Surgery, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa 920-8640, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hasegawa
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa 920-8640, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Hatano
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa 920-8640, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sugimoto
authors.affiliation: Pediatric Otolaryngology, Jichi Children's Medical Center Tochigi, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ito
authors.affiliation: Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan; Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan. Electronic address: hiroshi-kawasaki@umin.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawasaki
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa 920-8640, Japan. Electronic address: tomoy@med.kanazawa-u.ac.jp.
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Yoshizaki
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001306:Auditory Pathways / Q000378:metabolism; D003051:Cochlea / Q000293:injuries*; D017626:Cochlear Nucleus / Q000378:metabolism*; D007150:Immunohistochemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D065832:Superior Olivary Complex / Q000378:metabolism*; D050598:Vesicular Glutamate Transport Protein 1 / Q000378:metabolism*
chemical_list: C493466:Slc17a7 protein, rat; D050598:Vesicular Glutamate Transport Protein 1
keywords: Auditory pathway; Cochlear ablation; Vesicular glutamate transpoter 1