title: Ascending Spinal Cord Infarction Secondary to Recurrent Spinal Cord Cavernous Malformation Hemorrhage.
abstract: We report a case of a 58-year-old Hispanic man who developed ascending paraparesis over several weeks secondary to recurrent hemorrhages and resulting in spinal cord ischemia from a low thoracic spinal cord cavernous malformation. The patient's deterioration was attributed to recurrent hemorrhage of a thoracic intramedullary cavernous malformation at T11 resulting in vascular congestion and spinal cord ischemia. The patient was found to have a heterozygous mutation on exon 13 of gene KRIT1, which was consistent with autosomal dominant familial cerebral cavernous malformations. Expedited surgical intervention potentially could have prevented this patient's progressive paraplegia.
authors.affiliation: School of Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: Huntley.geoffrey@mayo.edu.
authors.forename: Geoffrey D
authors.initials: GD
authors.lastname: Huntley
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Ruff
authors.affiliation: Department of Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Hicks
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Micah D
authors.initials: MD
authors.lastname: Yost
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Jimmy R
authors.initials: JR
authors.lastname: Fulgham
mesh_terms: D000344:Afferent Pathways / Q000000981:diagnostic imaging / Q000473:pathology*; D020786:Hemangioma, Cavernous, Central Nervous System / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D007238:Infarction / Q000150:complications* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013116:Spinal Cord / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: Spinal cord hemorrhage; T-2 weighted magnetic resonance imaging; cerebral cavernous malformation; spinal cord ischemia