title: What Is Known about the Immune Response Induced byPlasmodium vivaxMalaria Vaccine Candidates?
abstract: Malaria caused byPlasmodium vivaxcontinues being one of the most important infectious diseases around the world;P. vivaxis the second most prevalent species and has the greatest geographic distribution. Developing an effective antimalarial vaccine is considered a relevant control strategy in the search for means of preventing the disease. Studying parasite-expressed proteins, which are essential in host cell invasion, has led to identifying the regions recognized by individuals who are naturally exposed to infection. Furthermore, immunogenicity studies have revealed that such regions can trigger a robust immune response that can inhibit sporozoite (hepatic stage) or merozoite (erythrocyte stage) invasion of a host cell and induce protection. This review provides a synthesis of the most important studies to date concerning the antigenicity and immunogenicity of both synthetic peptide and recombinant protein candidates for a vaccine against malaria produced byP. vivax.
authors.affiliation: Molecular Biology and Immunology Department, Fundación Instituto de Immunología de Colombia (FIDIC), Bogotá, Colombia; PhD Programme in Biomedical and Biological Sciences, Universidad del Rosario, Bogotá, Colombia.
authors.forename: Carolina
authors.initials: C
authors.lastname: López
authors.affiliation: Molecular Biology and Immunology Department, Fundación Instituto de Immunología de Colombia (FIDIC), Bogotá, Colombia; MSc Programme in Microbiology, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Yoelis
authors.initials: Y
authors.lastname: Yepes-Pérez
authors.affiliation: Molecular Biology and Immunology Department, Fundación Instituto de Immunología de Colombia (FIDIC) , Bogotá , Colombia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Hincapié-Escobar
authors.affiliation: Molecular Biology and Immunology Department, Fundación Instituto de Immunología de Colombia (FIDIC), Bogotá, Colombia; Universidad de Ciencias Aplicadas y Ambientales (UDCA), Bogotá, Colombia.
authors.forename: Diana
authors.initials: D
authors.lastname: Díaz-Arévalo
authors.affiliation: Molecular Biology and Immunology Department, Fundación Instituto de Immunología de Colombia (FIDIC), Bogotá, Colombia; Basic Sciences Department, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Patarroyo
keywords: Plasmodium vivax; antigenicity; immune response; immunogenicity; malaria