title: AANA Journal Course: Update for Nurse Anesthetists-Part 5-Use of Tranexamic Acid in Preventing Postpartum Hemorrhage.
abstract: Postpartum hemorrhage (PPH) continues to be a serious complication in both developed and underdeveloped countries. It remains the leading cause of maternal mortality in underdeveloped countries. Implementation of the World Health Organization guidelines of PPH treatment has reduced mortality. In addition, the prophylactic administration of tranexamic acid with uterotonic agents may contribute to the reduction of PPH. This evidence-based literature review of tranexamic acid will examine its mechanism of action as well as its effectiveness in prevention of PPH and blood loss reduction in elective surgery, obstetrics, and trauma.
authors.affiliation: Department of Nurse Anesthetist Practice at Florida International University College of Nursing and Health Sciences, Miami, Florida.
authors.forename: Derrick C
authors.initials: DC
authors.lastname: Glymph
authors.affiliation: Texas Wesleyan University, Fort Worth, Texas.
authors.forename: Tito D
authors.initials: TD
authors.lastname: Tubog
authors.affiliation: Department of Nurse Anesthetist Practice at Florida International University College of Nursing and Health Sciences, Miami, Florida.
authors.forename: Mariya
authors.initials: M
authors.lastname: Vedenikina
mesh_terms: D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009719:Nurse Anesthetists / Q000193:education*; D006473:Postpartum Hemorrhage / Q000517:prevention & control*; D011247:Pregnancy; D014148:Tranexamic Acid / Q000627:therapeutic use*
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid
keywords: blood loss; cesarean delivery; postpartum hemorrhage; tranexamic acid; vaginal delivery