title: Aortic Stenosis in Dialysis Patients.
abstract: Aortic valve stenosis occurs 10-20 years earlier in patients on dialysis compared with the general population. This is likely related to the exposure of the valve to a milieu that predisposes to calcification as well as increased shear stress across the valve. Objective assessment of stenosis severity is largely made using echocardiography though accurate interpretation requires an understanding of the potential pitfalls of the technique and the influence of cardiac output upon the gradient measured across the valve. Timing of valve replacement in severe aortic stenosis is predominantly guided by exercise-induced symptoms (breathlessness, chest pain and [pre] syncope), which are often difficult to assess in the dialysis population who may have limited exercise capacity and symptoms due to renal failure and other comorbidities. Finally, treatment of aortic stenosis remains a constantly evolving area with advances in both conventional surgery and percutaneous techniques.
authors.affiliation: International Centre for Circulatory Health, National Heart and Lung Institute, NIHR Imperial College Biomedical Research Centre, and Imperial College NHS Trust, London, United Kingdom.
authors.forename: Yousif
authors.initials: Y
authors.lastname: Ahmad
authors.affiliation: International Centre for Circulatory Health, National Heart and Lung Institute, NIHR Imperial College Biomedical Research Centre, and Imperial College NHS Trust, London, United Kingdom.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Bellamy
authors.affiliation: International Centre for Circulatory Health, National Heart and Lung Institute, NIHR Imperial College Biomedical Research Centre, and Imperial College NHS Trust, London, United Kingdom.
authors.forename: Christopher S R
authors.initials: CSR
authors.lastname: Baker
mesh_terms: D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D004452:Echocardiography; D014943:Global Health; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000628:therapy*; D006435:Renal Dialysis / Q000009:adverse effects*; D018570:Risk Assessment