title: Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice.
abstract: We previously demonstrated that chotosan (CTS), a traditional herbal formula called Kampo medicine, improves diabetes-induced cognitive deficits. In the present study, we investigated the antidepressant-like effects of CTS in mice. The administration of CTS (1.0 g/kg, for 3 days) decreased the immobility time in the forced-swim test, and this decrease was prevented by the prior administration of sulpiride (an antagonist of D2/3receptors) and WAY100635 (an antagonist of 5-HT1Areceptors). None of the treatments tested altered the locomotor activity of mice. These results suggest that CTS exerts antidepressant-like effects through changes in the serotonergic and dopaminergic systems.
authors.affiliation: Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan.
authors.forename: Sachie
authors.initials: S
authors.lastname: Sasaki-Hamada
authors.affiliation: Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan.
authors.forename: Azusa
authors.initials: A
authors.lastname: Suzuki
authors.affiliation: Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan.
authors.forename: Yudai
authors.initials: Y
authors.lastname: Ueda
authors.affiliation: Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, Japan.
authors.forename: Kinzo
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan. Electronic address: okaji@rs.noda.tus.ac.jp.
authors.forename: Jun-Ichiro
authors.initials: JI
authors.lastname: Oka
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D015259:Dopamine Agents / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D010134:Fenclonine / Q000737:chemistry; D007099:Imipramine / Q000737:chemistry / Q000494:pharmacology; D007650:Ketanserin / Q000737:chemistry / Q000494:pharmacology; D008124:Locomotion; D008297:Male; D020835:Medicine, Kampo; D008711:Metergoline / Q000737:chemistry; D051379:Mice; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D018490:Serotonin Agents / Q000494:pharmacology*; D013469:Sulpiride / Q000737:chemistry / Q000494:pharmacology; D013550:Swimming; D015016:Yohimbine / Q000737:chemistry
chemical_list: D000928:Antidepressive Agents; D015259:Dopamine Agents; D004365:Drugs, Chinese Herbal; D010879:Piperazines; D011725:Pyridines; D018490:Serotonin Agents; C120250:choto-san; D008711:Metergoline; D015016:Yohimbine; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide; D013469:Sulpiride; D007650:Ketanserin; D007099:Imipramine; D010134:Fenclonine
keywords: Antidepressants; Chotosan; Monoamine