title: Ex Vivo Lung Perfusion: A Key Tool for Translational Science in the Lungs.
abstract: Ex vivo lung perfusion (EVLP) promises to be a comprehensive platform for assessment, reconditioning, and preservation of donor lungs and has been dramatically changing the face of clinical lung transplantation. Besides its increasing role in lung transplantation, EVLP has also been recognized as a useful tool for translational research involving the lungs. Based on recent remarkable evidence and experience using EVLP in lung transplantation, there is growing interest in, and expectations for, the use of EVLP beyond the field of lung transplantation. By combining EVLP with advances in regenerative medicine, stem cell biology, and oncology, the evolving technology of EVLP has tremendous potential to advance pulmonary medicine and science. In this review, we revisit recent advances in EVLP technology and research and discuss the future translation of EVLP applications into life-changing medicine.
authors.affiliation: Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: Shinya
authors.initials: S
authors.lastname: Tane
authors.affiliation: Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Noda
authors.affiliation: Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA. Electronic address: shigemuran@upmc.edu.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Shigemura
mesh_terms: D057005:Bioengineering; D015316:Genetic Therapy; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008171:Lung Diseases / Q000628:therapy*; D016040:Lung Transplantation; D008495:Medical Oncology; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion / Q000379:methods*; D012121:Respiration, Artificial / Q000379:methods*; D033581:Stem Cell Transplantation; D057170:Translational Research, Biomedical; D014182:Transplantation, Autologous
keywords: bioengineering; ex vivo lung perfusion; lung; oncology; translational research