title: Effects of trimetazidine on interleukin-2 and interleukin-8 concentrations in patients with coronary artery disease.
abstract: Trimetazidine (TMZ) exhibits metabolic and cardioprotective effects. The aim of this study was to assess the effects of TMZ on interleukin-2 (IL-2) and interleukin-8 (IL-8) serum concentrations in 156 patients with stable coronary artery disease. They underwent a treadmill exercise test (TET) before and after 3 months of TMZ treatment. IL-2 and IL-8 concentrations were determined before and after each TET. Before treatment, TET did not influence IL-2 concentrations, whereas IL-8 concentrations increased. TMZ treatment led to a decrease in IL-2 concentrations before TET, as well as it prevented the increase of IL-8 following the second TET. Obtained results confirmed the improvement in TET performance during TMZ treatment and they revealed a significant influence of TMZ on IL-2 and IL-8 concentrations both before and after TET. These changes may reflect potential anti-inflammatory effects of TMZ.
authors.affiliation: a Department of Nutrition-Related Disease Prevention, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Danikiewicz
authors.affiliation: b Third Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Disease, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Szkodziński
authors.affiliation: a Department of Nutrition-Related Disease Prevention, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland.|b Third Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Disease, Poland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Hudzik
authors.affiliation: a Department of Nutrition-Related Disease Prevention, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland.
authors.forename: Ilona
authors.initials: I
authors.lastname: Korzonek-Szlacheta
authors.affiliation: b Third Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Disease, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Gąsior
authors.affiliation: a Department of Nutrition-Related Disease Prevention, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Zubelewicz-Szkodzińska
mesh_terms: D000328:Adult; D003324:Coronary Artery Disease / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013312:Stress, Physiological / Q000187:drug effects; D014292:Trimetazidine / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D007376:Interleukin-2; D016209:Interleukin-8; D014292:Trimetazidine
keywords: coronaropathie; coronary artery disease; interleukin-2; interleukin-8; interleukine-2; interleukine-8; trimetazidine; trimétazidine