title: Cardiac rehabilitation for women with breast cancer and treatment-related heart failure compared with coronary artery disease: A retrospective study.
abstract: OBJECTIVE
  To examine clinical outcomes and completion rates of cardiac rehabilitation in women with breast cancer and treatment-related heart failure.
  
  
  METHODS
  Data for women with breast cancer and treatment-related heart failure were compared with those for age-matched women with coronary artery disease. Retrospective data were obtained from the Toronto Rehabilitation Institute database for dates between 1998 and 2011, for cardiopulmonary exercise test results at baseline and 6 months, body composition measures, and cardiac rehabilitation completion rates.
  
  
  RESULTS
  A total of 29 women with breast cancer and treatment-related heart failure (mean 57 years (standard deviation (SD) 9.4)) and 29 age-matched women with coronary artery disease were identified. There was no significant difference between the proportion of women with breast cancer and treatment-related heart failure and those with coronary artery disease who completed the programme. Peak aerobic power (VO2peak) increased in the breast cancer and treatment-related heart failure group (mean 16.2 ml-1.kg-1.min-1 (SD 3.4) to mean 18.5 ml-1.kg-1.min-1 (SD 4.5) ; p = 0.002) and in the coronary artery disease group (mean 18.9 ml-1.kg-1.min-1 (SD 4.5) to mean 20.8 ml-1.kg-1.min-1 (SD 4.9); p = 0.01). Body fat percentage increased in the breast cancer and treatment-related heart failure group (mean 34.8% (SD 8.5) to mean 36.3% (SD 6.9); p = 0.04).
  
  
  CONCLUSIONS
  Women with breast cancer and treatment-related heart failure participating in cardiac rehabilitation demonstrate similar significant gains in VO2peak and similar completion rates to those of age-matched women with coronary artery disease. Further research is needed to determine interventions that improve body composition in women with breast cancer and treatment-related heart failure.
authors.affiliation: Toronto Rehabilitation Institute/University Health Network , , M5S 2C9 Toronto, Canada. alis.bonsignore@uhn.ca.
authors.forename: Alis
authors.initials: A
authors.lastname: Bonsignore
authors.forename: Susan
authors.initials: S
authors.lastname: Marzolini
authors.forename: Paul
authors.initials: P
authors.lastname: Oh
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D001823:Body Composition; D001943:Breast Neoplasms / Q000188:drug therapy; D000072038:Cardiac Rehabilitation / Q000379:methods*; D003324:Coronary Artery Disease / Q000503:physiopathology / Q000534:rehabilitation*; D005081:Exercise Therapy / Q000379:methods; D005260:Female; D006321:Heart / Q000503:physiopathology; D006333:Heart Failure / Q000139:chemically induced / Q000503:physiopathology / Q000534:rehabilitation*; D006339:Heart Rate; D006801:Humans; D008875:Middle Aged; D010101:Oxygen Consumption; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents