title: Analgesic effects of ultrasound-guided transverse abdominis plane block using different volumes and concentrations of local analgesics after laparoscopic cholecystectomy.
abstract: Objective To evaluate the effects of an ultrasound-guided transverse abdominis plane (US-TAP) block used for postoperative pain relief by comparing the efficacy of two different volumes/concentrations of the local anaesthetic bupivacaine in patients undergoing laparoscopic cholecystectomies. Methods This randomized study enrolled patients undergoing laparoscopic cholecystectomies. They were randomized to two groups: group A received a 20 ml US-TAP block (50 mg bupivacaine +10 ml saline solution) and group B received a 30 ml US-TAP block (50 mg bupivacaine + 20 ml saline solution). The intraoperative consumption of remifentanil, the requirement for postoperative rescue analgesics, patient satisfaction scores, postoperative complications, and postoperative pain as measured by a visual analogue scale at 20 min, 12 h, and 24 h were recorded. Results A total of 60 patients enrolled in the study. There were no differences between the two groups with respect to demographic characteristics, duration of anaesthesia and patient satisfaction scores. The intraoperative consumption of remifentanil, postoperative VAS scores (20 min, 12 h and 24 h) and the requirement for postoperative analgesics were all significantly lower in group B who received a larger volume but a lower concentration of local anaesthetic solution compared with group A. Conclusion A US-TAP block can form part of a balanced postoperative analgesic regimen following laparoscopic cholecystectomy.
authors.affiliation: 1 Department of Anaesthesiology and Reanimation, Istanbul Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, Turkey.
authors.forename: Ayça Sultan
authors.initials: AS
authors.lastname: Şahin
authors.affiliation: 1 Department of Anaesthesiology and Reanimation, Istanbul Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, Turkey.
authors.forename: Necmiye
authors.initials: N
authors.lastname: Ay
authors.affiliation: 2 Department of General Surgery, Istanbul Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, Turkey.
authors.forename: Nuri Alper
authors.initials: NA
authors.lastname: Şahbaz
authors.affiliation: 3 Engineering Faculty of Industrial Engineering, Kocaeli University, Kocaeli, Turkey.
authors.forename: Mehlika Kocabaş
authors.initials: MK
authors.lastname: Akay
authors.affiliation: 1 Department of Anaesthesiology and Reanimation, Istanbul Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Demiraran
authors.affiliation: 1 Department of Anaesthesiology and Reanimation, Istanbul Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, Turkey.
authors.forename: Abdurrahim
authors.initials: A
authors.lastname: Derbent
mesh_terms: D000009:Abdominal Muscles / Q000000981:diagnostic imaging / Q000294:innervation; D000293:Adolescent; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D002045:Bupivacaine; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods*; D010147:Pain Measurement / Q000379:methods; D010149:Postoperative Pain / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D010880:Piperidines; D011446:Prospective Studies; D000077208:Remifentanil; D014463:Ultrasonography
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D010880:Piperidines; D000077208:Remifentanil; D002045:Bupivacaine
keywords: Ultrasound-guided; laparoscopic cholecystectomy; postoperative pain; transverse abdominis plane block