title: Improving activities of daily living ability in women with fibromyalgia: An exploratory, quasi-randomized, phase-two study, IMPROvE trial.
abstract: OBJECTIVE
  To explore and compare the outcomes of adaptation and physical activity programmes regarding activities of daily living (ADL) ability following interdisciplinary rehabilitation in women with fibromyalgia.
  
  
  METHODS
  Participants (n = 85) were quasi-randomized to 16-week adaptation (ADAPT) or physical activity (ACTIVE) programmes following 2-week interdisciplinary rehabilitation. Primary outcomes were ADL motor and ADL process ability, measured with the Assessment of Motor and Process Skills (AMPS) at 4-week follow-up. Data were analysed per protocol.
  
  
  RESULTS
  Participants (ADAPT, n = 21; ACTIVE, n = 27) did not differ from withdrawers (n = 37). Improvements in ADL ability in the ADAPT (ADL motor mean change = 0.43 logits (95% confidence interval (95% CI) = 0.31-0.56); ADL process mean change = 0.34 logits (95% CI = 0.17-0.52)) and ACTIVE (ADL motor mean change = 0.33 logits (95% CI = 0.22-0.43); ADL process mean change = 0.25 logits (95% CI = 0.12-0.38)) groups were statistically significant, with no differences between groups. Responder analyses revealed that 63% of all participants obtained clinically relevant improvements in ADL motor ability and 48% in ADL process ability.
  
  
  CONCLUSIONS
  Although limited by a large drop-out, this exploratory study showed that both adaptation and physical activity programmes following interdisciplinary rehabilitation improved ADL ability in the majority of participants. ADL ability outcomes were independent of group allocation (ADAPT vs ACTIVE), suggesting efficacy of both programmes.
authors.affiliation: Department of Rheumatology, The Parker Institute, Frederiksberg Hospital, Nordre Fasanvej 57, DK-2000 Frederiksberg, Denmark. Cecilie.von.bulow@regionh.dk.
authors.forename: Cecilie
authors.initials: C
authors.lastname: von Bülow
authors.forename: Kirstine
authors.initials: K
authors.lastname: Amris
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Bandak
authors.forename: Bente
authors.initials: B
authors.lastname: Danneskiold-Samsøe
authors.forename: Eva Elisabet Ejlersen
authors.initials: EE
authors.lastname: Wæhrens
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D015444:Exercise; D005260:Female; D005356:Fibromyalgia / Q000534:rehabilitation*; D006801:Humans; D008875:Middle Aged; D065228:Non-Randomized Controlled Trials as Topic; D010348:Patient Care Team; D010352:Patient Dropouts / Q000706:statistics & numerical data; D016896:Treatment Outcome