title: Role of Nerve Growth Factor (NGF) and miRNAs in Epithelial Ovarian Cancer.
abstract: Ovarian cancer is the eighth most common cancer in women worldwide, and epithelial ovarian cancer (EOC) represents 90% of cases. Nerve growth factor (NGF) and its high affinity receptor tyrosine kinase A receptor (TRKA) have been associated with the development of several types of cancer, including EOC; both NGF and TRKA levels are elevated in this pathology. EOC presents high angiogenesis and several molecules have been reported to induce this process. NGF increases angiogenesis through its TRKA receptor on endothelial cells, and by indirectly inducing vascular endothelial growth factor expression. Other molecules controlled by NGF include ciclooxigenase-2, disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) and calreticulin (CRT), proteins involved in crucial processes needed for EOC progression. These molecules could be modified through microRNA regulation, which could be regulated by NGF. MicroRNAs are the widest family of non-coding RNAs; they bind to 3'-UTR of mRNAs to inhibit their translation, to deadenilate or to degraded them. In EOC, a deregulation in microRNA expression has been described, including alterations of miR-200 family, cluster-17-92, and miR-23b, among others. Since the NGF-microRNA relationship in pathologies has not been studied, this review proposes that some microRNAs could be associated with NGF/TRKA activation, modifying protein levels needed for EOC progression.
authors.affiliation: Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital University of Chile, Santiago 8380456, Chile. rmretama@gmail.com.
authors.forename: Rocío
authors.initials: R
authors.lastname: Retamales-Ortega
authors.affiliation: Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital University of Chile, Santiago 8380456, Chile. lorenaorostica@gmail.com.
authors.forename: Lorena
authors.initials: L
authors.lastname: Oróstica
authors.affiliation: Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital University of Chile, Santiago 8380456, Chile. carolinavera@ug.uchile.cl.
authors.forename: Carolina
authors.initials: C
authors.lastname: Vera
authors.affiliation: Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital University of Chile, Santiago 8380456, Chile. paucuevasl.2008@gmail.com.
authors.forename: Paula
authors.initials: P
authors.lastname: Cuevas
authors.affiliation: Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital University of Chile, Santiago 8380456, Chile. andrea.gx24@gmail.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Hernández
authors.affiliation: Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital University of Chile, Santiago 8380456, Chile. ihurtado@hcuch.cl.
authors.forename: Iván
authors.initials: I
authors.lastname: Hurtado
authors.affiliation: Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital University of Chile, Santiago 8380456, Chile. mvega@hcuch.cl.|Department of Obstetrics and Gynecology, Clinical Hospital, Faculty of Medicine, University of Chile, Santiago 8380456, Chile. mvega@hcuch.cl.
authors.forename: Margarita
authors.initials: M
authors.lastname: Vega
authors.affiliation: Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital University of Chile, Santiago 8380456, Chile. cromero@hcuch.cl.|Department of Obstetrics and Gynecology, Clinical Hospital, Faculty of Medicine, University of Chile, Santiago 8380456, Chile. cromero@hcuch.cl.|Advanced Center for Chronic Diseases (ACCDiS), Santiago 8380456, Chile. cromero@hcuch.cl.
authors.forename: Carmen
authors.initials: C
authors.lastname: Romero
mesh_terms: D000818:Animals; D015415:Biomarkers; D000077216:Carcinoma, Ovarian Epithelial; D002352:Carrier Proteins; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D020932:Nerve Growth Factor / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D011485:Protein Binding; D034622:RNA Interference; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D002352:Carrier Proteins; D035683:MicroRNAs; D020932:Nerve Growth Factor
keywords: Tyrosine kinase A receptor (TRKA); epithelial ovarian cancer; microRNAs; nerve growth factor (NGF); neurotrophins