title: Effective Strategies and Applications of Dendrimers in the Treatment of Ovarian Cancer.
abstract: Ovarian cancer, the worldwide leading cause of gynecological cancer-related death, is primarily treated by surgery followed by platinum chemotherapy. Though the tumor initially responds to the treatment, only 30% of 5 year survival period has been recorded and this is mainly attributed to the acquired chemo resistance and frequent recurrence of tumor. Combination chemotherapy as well, led to therapeutic failure due to non-specificity and subsequent side effects. However, polymer mediated drug delivery aids in overcoming these impediments. In particular, three dimensional macromolecule "Dendrimer" with its unique properties and numerous functionalities offer various advantages over the conventional approach and may improve the treatment outcome in patients with ovarian cancer. The present review highlights the various strategies employed using dendrimers to achieve targeted drug delivery and enhanced therapeutic efficacy in ovarian cancer.
authors.affiliation: Department of Human Genetics, Faculty of Biomedical Sciences, Technology & Research, & Sri Ramachandra Center for Biomedical Nanotechnology, Sri Ramachandra University, Porur, Chennai-600116, Tamil Nadu. India.
authors.forename: Akila
authors.initials: A
authors.lastname: Kesavan
authors.affiliation: Department of Biology, Indian Institute of Science Education and Research, Tirupati, Andhra Pradesh, 517507. India.
authors.forename: Suresh Babu
authors.initials: SB
authors.lastname: Pakala
authors.affiliation: Department of Biotechnology, IIT-M, Chennai-36. India.
authors.forename: Suresh K
authors.initials: SK
authors.lastname: Rayala
authors.affiliation: Department of Human Genetics, Faculty of Biomedical Sciences, Technology & Research, & Sri Ramachandra Center for Biomedical Nanotechnology, Sri Ramachandra University, Porur, Chennai-600116, Tamil Nadu. India.
authors.forename: Ganesh
authors.initials: G
authors.lastname: Venkatraman
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D050091:Dendrimers / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D050091:Dendrimers
keywords: Ovarian cancer; asymptomatic; dendrimer; drug delivery systems; strategies; targeted drug delivery.