title: Cytokine Imbalance as a Common Mechanism in Both Psoriasis and Rheumatoid Arthritis.
abstract: Psoriasis (PS) and rheumatoid arthritis (RA) are immune-mediated inflammatory diseases. Previous studies showed that these two diseases had a common pathogenesis, but the precise molecular mechanism remains unclear. In this study, RNA sequencing of peripheral blood mononuclear cells was employed to explore both the differentially expressed genes (DEGs) of 10 PS and 10 RA patients compared with those of 10 healthy volunteers and the shared DEGs between these two diseases. Bioinformatics network analysis was used to reveal the connections among the shared DEGs and the corresponding molecular mechanism. In total, 120 and 212 DEGs were identified in PS and RA, respectively, and 31 shared DEGs were identified. Bioinformatics analysis indicated that the cytokine imbalance relevant to key molecules (such as extracellular signal-regulated kinase 1/2 (ERK1/2), p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor (TNF), colony-stimulating factor 3 (CSF3), interleukin- (IL-) 6, and interferon gene (IFNG)) and canonical signaling pathways (such as the complement system, antigen presentation, macropinocytosis signaling, nuclear factor-kappa B (NF-κB) signaling, and IL-17 signaling) was responsible for the common comprehensive mechanism of PS and RA. Our findings provide a better understanding of the pathogenesis of PS and RA, suggesting potential strategies for treating and preventing both diseases. This study may also provide a new paradigm for illuminating the common pathogenesis of different diseases.
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Institute of Clinical Pharmacology, Beijing An Zhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Qi
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Cheng
authors.identifier: 0000-0002-6474-9198
authors.initials: C
authors.lastname: Lu
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Xuyan
authors.identifier: 0000-0003-1320-2667
authors.initials: X
authors.lastname: Niu
authors.affiliation: Department of Dermatology, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Beijing 100010, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Dermatology and Venerology, Peking University First Hospital, Beijing 100034, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada; Molecular Medicine Laboratory and Chieng Genomics Center, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
authors.forename: Youwen
authors.identifier: 0000-0001-7633-4136
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China; Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong; E-Institute of Chinese Traditional Internal Medicine, Shanghai Municipal Education Commission, Shanghai 201203, China.
authors.forename: Aiping
authors.identifier: 0000-0002-2303-0494
authors.initials: A
authors.lastname: Lu
authors.affiliation: Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Cheng
authors.identifier: 0000-0002-5601-9670
authors.initials: C
authors.lastname: Xiao
mesh_terms: D000328:Adult; D017951:Antigen Presentation; D001172:Arthritis, Rheumatoid / Q000097:blood*; D016022:Case-Control Studies; D003165:Complement System Proteins; D019295:Computational Biology; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007107:Immune System; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D011565:Psoriasis / Q000097:blood*; D015398:Signal Transduction; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D016760:Proto-Oncogene Proteins c-fos; D003165:Complement System Proteins; D048051:p38 Mitogen-Activated Protein Kinases