title: Stacking transgenic event DAS-Ø15Ø7-1 alters maize composition less than traditional breeding.
abstract: The impact of crossing ('stacking') genetically modified (GM) events on maize-grain biochemical composition was compared with the impact of generating nonGM hybrids. The compositional similarity of seven GM stacks containing event DAS-Ø15Ø7-1, and their matched nonGM near-isogenic hybrids (iso-hybrids) was compared with the compositional similarity of concurrently grown nonGM hybrids and these same iso-hybrids. Scatter plots were used to visualize comparisons among hybrids and a coefficient of identity (per cent of variation explained by line of identity) was calculated to quantify the relationships within analyte profiles. The composition of GM breeding stacks was more similar to the composition of iso-hybrids than was the composition of nonGM hybrids. NonGM breeding more strongly influenced crop composition than did transgenesis or stacking of GM events. These findings call into question the value of uniquely requiring composition studies for GM crops, especially for breeding stacks composed of GM events previously found to be compositionally normal.
authors.affiliation: Dow AgroSciences LLC, Indianapolis, IN, USA.
authors.forename: Rod A
authors.initials: RA
authors.lastname: Herman
authors.affiliation: Dow AgroSciences LLC, Indianapolis, IN, USA.
authors.forename: Brandon J
authors.initials: BJ
authors.lastname: Fast
authors.affiliation: Dow AgroSciences LLC, Indianapolis, IN, USA.
authors.forename: Peter N
authors.initials: PN
authors.lastname: Scherer
authors.affiliation: Dow AgroSciences LLC, Indianapolis, IN, USA.
authors.forename: Alyssa M
authors.initials: AM
authors.lastname: Brune
authors.affiliation: Dow AgroSciencies Sementes e Biotecnologia Brasil LTDA, Cravinhos, SP, Brazil.
authors.forename: Denise T
authors.initials: DT
authors.lastname: de Cerqueira
authors.affiliation: Dow AgroSciences LLC, Indianapolis, IN, USA.
authors.forename: Barry W
authors.initials: BW
authors.lastname: Schafer
authors.affiliation: Dow AgroSciences LLC, Indianapolis, IN, USA.
authors.forename: Ricardo D
authors.initials: RD
authors.lastname: Ekmay
authors.affiliation: Dow AgroSciences LLC, Indianapolis, IN, USA.
authors.forename: George G
authors.initials: GG
authors.lastname: Harrigan
authors.affiliation: Dow AgroSciences LLC, Indianapolis, IN, USA.
authors.forename: Greg A
authors.initials: GA
authors.lastname: Bradfisch
mesh_terms: D018556:Crops, Agricultural / Q000235:genetics*; D005818:Genetic Engineering; D006824:Hybridization, Genetic; D000069600:Plant Breeding; D030821:Plants, Genetically Modified / Q000737:chemistry / Q000235:genetics*; D003313:Zea mays / Q000737:chemistry / Q000235:genetics*
keywords: breeding stacks; composition; equivalence