title: Self-Assembling Molecular Logic Gates Based on DNA Crossover Tiles.
abstract: DNA-based computational hardware has attracted ever-growing attention due to its potential to be useful in the analysis of complex mixtures of biological markers. Here we report the design of self-assembling logic gates that recognize DNA inputs and assemble into crossover tiles when the output signal is high; the crossover structures disassemble to form separate DNA stands when the output is low. The output signal can be conveniently detected by fluorescence using a molecular beacon probe as a reporter. AND, NOT, and OR logic gates were designed. We demonstrate that the gates can connect to each other to produce other logic functions.
authors.affiliation: Chemistry Department, University of Central Florida, 4000 Central Florida Boulevard, Orlando, FL, 32816-2366, USA.
authors.forename: Eleanor A
authors.initials: EA
authors.lastname: Campbell
authors.affiliation: Chemistry Department, University of Central Florida, 4000 Central Florida Boulevard, Orlando, FL, 32816-2366, USA.
authors.forename: Evan
authors.initials: E
authors.lastname: Peterson
authors.affiliation: Chemistry Department, University of Central Florida, 4000 Central Florida Boulevard, Orlando, FL, 32816-2366, USA.|Burnett School of Biomedical Sciences, College of Medicine and National Center for Forensic Science, University of Central Florida, Orlando, FL, 32816, USA)An invited contribution to a Special Issue on Molecular Logic.
authors.forename: Dmitry M
authors.initials: DM
authors.lastname: Kolpashchikov
mesh_terms: D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry*; D005453:Fluorescence; D008128:Logic; D008163:Luminescent Measurements
chemical_list: D004247:DNA
keywords: DNA computation; DNA nanotechnology; crossover tile; molecular beacon probe; molecular logic gates