title: γ-Butenolide and furanone derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178.
abstract: Chromatographic separation of the broth extract of the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178 resulted in isolation of four γ-butenolide-furanone dimers, aspersclerotiorones A-D, a furanone derivative, aspersclerotiorone E, and two γ-butenolide derivatives, aspersclerotiorones F and G, together with six known compounds, penicillic acid, dihydropenicillic acid, 5,6-dihydro-6-hydroxypenicillic acid, 6-methoxy-5,6-dihydropenicillic acid, coculnol and (4R,5R)-4,5-dihydroxy-3-methoxy-5-methylcyclohex-2-en-1-one. Their structures were determined by spectroscopic evidence. For aspersclerotiorones A and B, the structures were confirmed by single-crystal X-ray diffraction crystallography. Penicillic acid displayed weak antibacterial activity against Staphylococcus aureus and Escherichia coli with equal MIC values of 128 μg/mL, and it was noncytotoxic towards African green monkey kidney fibroblast cells.
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
authors.forename: Patima
authors.initials: P
authors.lastname: Phainuphong
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand. Electronic address: vatcharin.r@psu.ac.th.
authors.forename: Vatcharin
authors.initials: V
authors.lastname: Rukachaisirikul
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
authors.forename: Kwanruthai
authors.initials: K
authors.lastname: Tadpetch
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
authors.forename: Yaowapa
authors.initials: Y
authors.lastname: Sukpondma
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
authors.forename: Saowanit
authors.initials: S
authors.lastname: Saithong
authors.affiliation: Natural Products Research Center of Excellence and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
authors.forename: Souwalak
authors.initials: S
authors.lastname: Phongpaichit
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand.
authors.forename: Sita
authors.initials: S
authors.lastname: Preedanon
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand.
authors.forename: Jariya
authors.initials: J
authors.lastname: Sakayaroj
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification; D001230:Aspergillus / Q000737:chemistry*; D002522:Chlorocebus aethiops; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D012988:Soil Microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D013785:Thailand; D014709:Vero Cells
chemical_list: D000900:Anti-Bacterial Agents; C004511:butenolide; D015107:4-Butyrolactone
keywords: Antibacterial; Antifungal; Aspergillus sclerotiorum; Cytotoxic; Furanone derivatives; γ-butenolides