title: Correlation of Acute M1 Middle Cerebral Artery Thrombus Location with Endovascular Treatment Success and Clinical Outcome.
abstract: OBJECTIVE
  The location of the arterial occlusion can help with prognostication and treatment triage of acute stroke patients. We aimed to determine the effects of M1 distance-to-thrombus on angiographic recanalization success rate and clinical outcome following endovascular treatment of acute M1 occlusion.
  
  
  METHODS
  All acute ischemic stroke patients with M1 segment middle cerebral artery (MCA) occlusion on admission CT angiography (CTA) who underwent endovascular treatment were analyzed. The distance between thrombus origin and internal carotid artery (ICA) bifurcation was measured on admission CTA. The modified thrombolysis in cerebral infarction (mTICI) grades 2b(>50% of distal branch filling) and 3 (complete) were considered as successful recanalization. Favorable outcome was defined by 3-month follow-up modified Rankin scale (mRs) score ≤2.
  
  
  RESULTS
  Successful recanalization was achieved in 24 (71%) of 34 consecutive patients included in this study. The M1 distance-to-thrombus was shorter among patients with successful recanalization (5.4 ± 5.4 mm) versus those without (11.3 ± 7.6 mm,p= 0.015). The successful recanalization rate was higher among patients with M1 distance-to-thrombus ≤6 mm (odds ratio: 8, 95% confidence interval: 1.37-46.81,p= 0.023) compared with those with distance-to-thrombus >6 mm. There was no significant correlation between M1 distance-to-thrombus and 3-month mRs (rho: 0.131,p= 0.461); however, the distance-to-thrombus negatively correlated with admission National Institutes of Health Stroke Scale (NIHSS) scores (rho: -0.350, p=0.043). On the other hand, successful recanalization and admission NIHSS score were the only independent predictors of favorable outcome.
  
  
  CONCLUSIONS
  Shorter distance of M1 thrombus from ICA bifurcation is associated with higher rate of successful recanalization following endovascular treatment.
authors.affiliation: Zeenat Qureshi Stroke Institute, St. Cloud, MN, USA; Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Seyedmehdi
authors.initials: S
authors.lastname: Pavabvash
authors.affiliation: Zeenat Qureshi Stroke Institute, St. Cloud, MN, USA.
authors.forename: Shayandokht
authors.initials: S
authors.lastname: Taleb
authors.affiliation: Zeenat Qureshi Stroke Institute, St. Cloud, MN, USA.
authors.forename: Shahram
authors.initials: S
authors.lastname: Majidi
authors.affiliation: Zeenat Qureshi Stroke Institute, St. Cloud, MN, USA.
authors.forename: Adnan I
authors.initials: AI
authors.lastname: Qureshi
keywords: CT angiography (CTA); acute ischemic stroke; middle cerebral artery (MCA); recanalization; thrombus