title: Lifespan Risk Exposure Measurement Instrument: a Feasible and Effective Tool for Life Course Epidemiology Research.
abstract: Life course epidemiology should practically illustrate how risk exposures and their dynamic changes influence the occurrence, development and prognosis of chronic diseases from early life to the elderly. This paper develops the lifespan risk exposure measurement instrument (LREMI) in the framework of retrospective study to collect lifestyle, diet, physical activity information across subjects'life courses from 18-years-old to current age. Through a pilot study, the result of the test-retest analysis demonstrated the reliability of LREMI. In Shandong Multicenter Cohort, the LREMI showed its feasibility, for it could measure the exposure spectrum on both individuals and population with different life experiences. Moreover, it had good differentiation ability for identifying cases versus controls in population-based case-control study. However, further studies should be conducted in an already available prospective cohort to ascertain that our results could match prospective data.
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China.
authors.forename: Li Jie
authors.initials: LJ
authors.lastname: Ding
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China.
authors.forename: Rui Hong
authors.initials: RH
authors.lastname: Liu
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China.
authors.forename: Xiao Kang
authors.initials: XK
authors.lastname: Ji
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China.
authors.forename: Zhong Shang
authors.initials: ZS
authors.lastname: Yuan
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China.
authors.forename: Fu Zhong
authors.initials: FZ
authors.lastname: Xue
mesh_terms: D004781:Environmental Exposure; D004812:Epidemiologic Methods; D006801:Humans; D008019:Life Style; D012189:Retrospective Studies