title: Triphenyl Phosphine-Functionalized Chitosan Nanoparticles Enhanced Antitumor Efficiency Through Targeted Delivery of Doxorubicin to Mitochondria.
abstract: Mitochondria as an important organ in eukaryotic cells produced energy through oxidative phosphorylation and also played an important role in regulating the apoptotic signal transduction process. Importantly, mitochondria like nuclei also contained the functional DNA and were very sensitive to anticancer drugs which could effectively inhibit the synthesis of nucleic acid, especially the production of DNA. In this work, we designed novel triphenyl phosphine (TPP)-conjugated chitosan (CS) nanoparticles (NPs) for efficient drug delivery to cell mitochondria. The results showed that compared with free doxorubicin (Dox), Dox-loaded TPP-NPs were specifically distributed in mitochondria of tumor cells and interfered with the function of mitochondria, thus resulted in the higher cytotoxicity and induced the significant cell apoptosis effect. Taken together, triphenyl phosphine-conjugated chitosan nanoparticles may become a promising mitochondria-targeting nanocarrier candidate for enhancing antitumor effects.
authors.affiliation: School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Hou
authors.affiliation: School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.
authors.forename: Xiwei
authors.initials: X
authors.lastname: Yu
authors.affiliation: School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Shen
authors.affiliation: School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.
authors.forename: Yijie
authors.initials: Y
authors.lastname: Shi
authors.affiliation: School of Veterinary Medicine, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.
authors.forename: Chang
authors.initials: C
authors.lastname: Su
authors.affiliation: School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China. liangzhao79@163.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhao
keywords: Chitosan; Cytotoxicity; Doxorubicin; Mitochondria; Nanoparticles