title: [Expression of CD146 in Adult and Children's Acute B Cell Lymphoblastic Leukemia and Its Significance].
abstract: OBJECTIVE
  To explore the differences of CD146 expression in adult and children's acute B cell lymphoblastic leukemia(B-ALL), and its relation with clinical features, molecular biological and cytogenctic claracteristics.
  
  
  METHODS
  The expression of CD146 in bone marrow samples from adult and children's B-ALL patients were detected by flow cytometry (FCM) and the relation of CD146 abnormal high expression with the patients' clinical features, molecular biological and cytogenetical characteristics, as well as other antigens were analyzed.
  
  
  RESULTS
  The abnormal high expression rates of CD146 in adult and children's B-ALL patients were 29.17% and 9.09% respectively, showing that the expression rate of CD146 in adult patients was higher than that in children's patients(P<0.05). In adult B-ALL, CD146 was positively related with CD64 and CD117, while in children's B-ALL CD146 was positively related with CD71 and CD58 (P<0.05). After 1 course of standardized chemotherapy, the complete remission rates in adult and children's B-ALL patients with abnormal high expression of CD146 both were low as compared with adult and children's B-ALL without abnormal high expression of CD146 (P<0.05).
  
  
  CONCLUSIONS
  The expression rate of CD146 in adult B-ALL is higher than that in children's B-ALL. The CD146 positively relates with poor prognostic antigens, the CD146 may be one poor prognosis marker.
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China.
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Xie
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China.
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China.
authors.forename: Si-Lin
authors.initials: SL
authors.lastname: Gan
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China.
authors.forename: Sheng-Mei
authors.initials: SM
authors.lastname: Chen
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China.
authors.forename: Qiu-Tang
authors.initials: QT
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Xie
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China.
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Liu
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China.
authors.forename: Yuan-Dong
authors.initials: YD
authors.lastname: Cheng
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Liu
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China.
authors.forename: Xue-Ju
authors.initials: XJ
authors.lastname: Xu
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China. E-mail: sunhui371@medmail.com.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Sun
mesh_terms: D000328:Adult; D001402:B-Lymphocytes; D051929:CD146 Antigen / Q000378:metabolism; D002648:Child; D005434:Flow Cytometry; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000378:metabolism*; D011379:Prognosis; D012074:Remission Induction
chemical_list: D051929:CD146 Antigen; C497902:MCAM protein, human