title: Circulating endothelial cells, circulating endothelial progenitor cells, and von Willebrand factor in pregnancies complicated by hypertensive disorders.
abstract: OBJECTIVE
  We tested the hypothesis that the number of both CECs and CEPCs as well as the vWf blood plasma concentration are altered in pregnant women with hypertensive disorders.
  
  
  METHODS
  Seventy-five pregnant women were enrolled in our study. We used multicolor flow cytometry for CEC and CEPC analysis and the commercial human VWF ELISA kit to measure vWf blood plasma concentration.
  
  
  RESULTS
  The highest number of CECs was found in the chronic hypertension group and the lowest number in the healthy pregnant control group. The highest number of CEPCs was found in the control group and the lowest number in the chronic hypertension group. The vWf blood plasma concentration was the highest in the pre-eclampsia group. The CEPC/CEC ratio reached its lowest value in the chronic hypertension group and its highest value in the control group.
  
  
  CONCLUSIONS
  The number of both CECs and CEPCs as well as the vWf blood plasma concentration depends on the type of hypertension complicating the pregnancy.
authors.affiliation: Department of Perinatology and Gynecology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Szpera-Goździewicz
authors.affiliation: Department of Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Majcherek
authors.affiliation: Department of Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Boruczkowski
authors.affiliation: Department of Gynecology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Goździewicz
authors.affiliation: Department of Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Dworacki
authors.affiliation: Department of Oncology, Radiotherapy and Gynecological Oncology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Wicherek
authors.affiliation: Department of Perinatology and Gynecology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Grzegorz Henryk
authors.initials: GH
authors.lastname: Bręborowicz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001773:Blood Cells / Q000502:physiology*; D002454:Cell Differentiation; D042783:Endothelial Cells / Q000502:physiology*; D066026:Endothelial Progenitor Cells / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D015415:Biomarkers; D014841:von Willebrand Factor
keywords: endothelium; hypertension; multicolor flow cytometry; pre-eclampsia; pregnancy