title: Effect of habitual exercise on urinary liver-type fatty acid-binding protein levels in middle-aged and older adults.
abstract: The purpose of this study was to examine the effect of habitual exercise on urinary liver-type fatty acid-binding protein (L-FABP), which can reflect the degree of various stresses on renal proximal tubule related to the progression of renal disease, in middle-aged and older adults. Cross-sectional and interventional approaches were used to comprehensively achieve this purpose. In the cross-sectional study, we investigated the relationship between physical activity levels and urinary L-FABP levels in 130 middle-aged and older adults. In the interventional study, subjects (n=31) were divided into two groups: exercise (n=19) and control group (n=12), whereby we examined the effects of 12-week aerobic exercise training on urinary L-FABP levels. The cross-sectional study showed that the urinary L-FABP levels were significantly lower in the higher physical activity group than in the lower physical activity group (P<.05). In the interventional study, 12-week aerobic exercise training significantly decreased urinary L-FABP levels (P<.01). Furthermore, the relative changes in urinary L-FABP levels were significantly correlated with the relative changes in physical activity levels and mean arterial pressure after intervention (r=-.374 and r=.530, respectively). Our results revealed that the urinary L-FABP levels were lower in the higher physical activity individuals, and aerobic exercise training decreased urinary L-FABP levels. These results suggest that habitual exercise appears to be associated with a decrease in the degree of several stresses on renal proximal tubule and to be beneficial for kidney health in middle-aged and older adults.
authors.affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kosaki
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.|Department of Anatomy, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kamijo-Ikemori
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.|CMIC Company, Limited, Bunkyo, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sugaya
authors.affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tanahashi
authors.affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sawano
authors.affiliation: Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Akazawa
authors.affiliation: Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan.
authors.forename: S-G
authors.initials: SG
authors.lastname: Ra
authors.affiliation: JCHO Tokyo Takanawa Hospital, Minato, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shibagaki
authors.affiliation: Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: S
authors.identifier: http://orcid.org/0000-0003-1642-4644
authors.initials: S
authors.lastname: Maeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000652:urine; D003430:Cross-Sectional Studies; D015444:Exercise; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D005260:Female; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000502:physiology; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins
keywords: aerobic exercise training; exercise habituation; kidney; renoprotective effect; tubular biomarker