title: Alteration of serum levels of inflammatory cytokines and polysomnographic indices after uvulopalatal flap surgery in obstructive sleep apnea.
abstract: The aim of the current study was to compare the changes in polysomnographic indices and serum levels of C-reactive protein (CRP), cystatin C, tumor necrosis factor-α (TNF-α), and intercellular adhesion molecule-1 (ICAM-1) in patients with obstructive sleep apnea (OSA) who were treated surgically via a uvulopalatal flap (UPF) technique. Twenty-five patients (14 men, 11 women), average age 46.2 ± 9.3 years, who underwent UPF surgery were included in this study. Serum biochemical analyses and polysomnographic examinations were performed before and 6 months after the surgery. Pre- and postoperative values of apnea hypopnea index (AHI), oxygen desaturation index (ODI), and minimum oxygen concentrations, as well as serum levels of CRP, cystatin C, TNF-α, and ICAM-1 were compared. Comparison of variables before and after UPF surgery demonstrated that AHI (p = 0.001), ODI (p < 0.001) and oxygen saturation (p < 0.001) were significantly improved. In addition, serum levels of CRP (p = 0.036), cystatin C (p = 0.005), TNF-α (p < 0.001), and ICAM-1 (p < 0.001) were significantly reduced 6 months after surgery. Our results suggest that UPF is an effective surgical method that alleviates the severity of OSA. Moreover, it may have the potential to prevent the development of atherosclerosis by attenuating the inflammatory process induced by activation of inflammatory mediators such as CRP, TNF-α, ICAM-1, and cystatin C.
authors.affiliation: Department of Otorhinolaryngology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey. muradmutlu78@yahoo.com.
authors.forename: Murad
authors.initials: M
authors.lastname: Mutlu
authors.forename: Erkan
authors.initials: E
authors.lastname: Vuralkan
authors.forename: Istemihan
authors.initials: I
authors.lastname: Akin
authors.forename: Hikmet
authors.initials: H
authors.lastname: Firat
authors.forename: Sadik
authors.initials: S
authors.lastname: Ardic
authors.forename: Sevgi
authors.initials: S
authors.lastname: Akaydin
authors.forename: Ece
authors.initials: E
authors.lastname: Miser
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D055316:Cystatin C / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010159:Palate / Q000601:surgery*; D017286:Polysomnography / Q000706:statistics & numerical data; D011184:Postoperative Period; D057234:Preoperative Period; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D013524:Surgical Flaps; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014609:Uvula / Q000637:transplantation*
chemical_list: C525030:CST3 protein, human; D055316:Cystatin C; D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein