title: Functional connectivity in amygdalar-sensory/(pre)motor networks at rest: new evidence from the Human Connectome Project.
abstract: The word 'e-motion' derives from the Latin word 'ex-moveo' which literally means 'moving away from something/somebody'. Emotions are thus fundamental to prime action and goal-directed behavior with obvious implications for individual's survival. However, the brain mechanisms underlying the interactions between emotional and motor cortical systems remain poorly understood. A recent diffusion tensor imaging study in humans has reported the existence of direct anatomical connections between the amygdala and sensory/(pre)motor cortices, corroborating an initial observation in animal research. Nevertheless, the functional significance of these amygdala-sensory/(pre)motor pathways remain uncertain. More specifically, it is currently unclear whether a distinct amygdala-sensory/(pre)motor circuit can be identified with resting-state functional magnetic resonance imaging (rs-fMRI). This is a key issue, as rs-fMRI offers an opportunity to simultaneously examine distinct neural circuits that underpin different cognitive, emotional and motor functions, while minimizing task-related performance confounds. We therefore tested the hypothesis that the amygdala and sensory/(pre)motor cortices could be identified as part of the same resting-state functional connectivity network. To this end, we examined independent component analysis results in a very large rs-fMRI data-set drawn from the Human Connectome Project (n = 820 participants, mean age: 28.5 years). To our knowledge, we report for the first time the existence of a distinct amygdala-sensory/(pre)motor functional network at rest. rs-fMRI studies are now warranted to examine potential abnormalities in this circuit in psychiatric and neurological diseases that may be associated with alterations in the amygdala-sensory/(pre)motor pathways (e.g. conversion disorders, impulse control disorders, amyotrophic lateral sclerosis and multiple sclerosis).
authors.affiliation: Department of Biomedicine and Prevention, University of Rome"Tor Vergata", Rome, Italy.|Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA.|Harvard Medical School, Boston, MA, USA.
authors.forename: Nicola
authors.initials: N
authors.lastname: Toschi
authors.affiliation: Department of Biomedicine and Prevention, University of Rome"Tor Vergata", Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Duggento
authors.affiliation: Institute of Bioimaging and Molecular Physiology, National Research Council, Catanzaro, Italy.|Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0SZ, UK.
authors.forename: Luca
authors.initials: L
authors.lastname: Passamonti
mesh_terms: D000679:Amygdala / Q000502:physiology*; D063132:Connectome / Q000379:methods; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009044:Motor Cortex; D009415:Nerve Net; D009434:Neural Pathways; D012146:Rest / Q000502:physiology*
keywords: amygdala; limbic circuits; premotor cortex; resting-state fMRI; sensory-motor cortex