title: Multiple nonsyndromic acquired basal cell carcinomas : Uncommon clinical presentation in a Bulgarian patient.
abstract: Basal cell carcinoma is the most frequent cutaneous neoplasm, with slowly progressive nature and locally invasive behavior. Despite the low metastatic potential, local tissue destruction and disfigurement caused by the tumor can be large if not eradicated in time by early diagnosis and treatment. Both genetic predisposition and exposure to environmental risks are involved in the pathogenesis of the malignant transformation in BCC. The total number of nonmelanocytic skin cancers is a risk factor for recurrence of previous tumor, on the one hand, as well as for the formation of new ones, on the other. It is still unclear what environmental and genetic factors contribute to the development of multiple nonsyndromic BCCs. We present a man with multiple sporadic, nonsyndromic BCCs, with a history of even more lesions, removed earlier, as we discuss the potential triggering risk factors and pathogenic mechanisms of malignant transformation and the further appropriate therapeutic options. The early detection and eradication of these tumors are of importance for treatment effectiveness and quality of life because although rarely metastatic, BCCs could have an aggressive course and behavior which can lead to severe disfiguration and destruction.
authors.affiliation: Department of Dermatology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR), Generel Skobelev 79, 1606, Sofia, Bulgaria. georgi_tchernev@yahoo.de.
authors.forename: Georgi
authors.initials: G
authors.lastname: Tchernev
authors.affiliation: Department of General, Vascular and Abdominal Surgery, Medical Institute of Ministry of Interior, Generel Skobelev 79, 1606, Sofia, Bulgaria.
authors.forename: Ivan
authors.initials: I
authors.lastname: Pidakev
authors.affiliation: Department of General, Vascular and Abdominal Surgery, Medical Institute of Ministry of Interior, Generel Skobelev 79, 1606, Sofia, Bulgaria.
authors.forename: Ilia
authors.initials: I
authors.lastname: Lozev
authors.affiliation: University of Rome "G. Marconi", Rome, Italy.
authors.forename: Torello
authors.initials: T
authors.lastname: Lotti
authors.affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Wollina
mesh_terms: D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D042241:Early Diagnosis; D061345:Early Medical Intervention; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D012086:Reoperation; D012307:Risk Factors; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*
keywords: BCC; Multiple basal cell carcinoma; Nonmelanoma skin cancer