title: [Concomitant use of abiraterone acetate and triptorelin in patients with castration-resistant prostate cancer].
abstract: The relevance of drug treatment for prostate cancer increases with the number of patients who develop castration resistance. Currently, no unified treatment regimen for castration-resistant prostate cancer exists, but the standard treatment for these patients is continuous androgen deprivation therapy. This paper presents the experience of concomitant use of abiraterone acetate and triptorelin in patients with castration-resistant prostate cancer. Ten patients with disease duration of 1.5 to 18 years and established castration resistance are currently being followed up. Nine of ten patients have long-term bone metastases, one patient has visceral metastases. The combination therapy produced a significant PSA decrease in nine patients and regression of bone lesions in two patients.
authors.affiliation: The Department of Urology of Medical Faculty, I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Rapoport
authors.affiliation: The Department of Urology of Medical Faculty, I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Bezrukov
authors.affiliation: The Department of Urology of Medical Faculty, I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kondrashina
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000736:Androstenes / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy* / Q000473:pathology; D017329:Triptorelin Pamoate / Q000008:administration & dosage
chemical_list: D000736:Androstenes; D017329:Triptorelin Pamoate; C089740:abiraterone
keywords: abiraterone acetate; castration-resistant prostate cancer; triptorelin