title: Successful treatment of histiocytic sarcoma with cladribine and high-dose cytosine arabinoside in a child.
abstract: Histiocytic sarcoma, a rare hematopoietic neoplasm with evidence of histiocytic differentiation, is often refractory to conventional chemotherapy and radiotherapy, and its prognosis is generally dismal. The optimal management of this malignancy has not been established. We report a case of 8-year-old girl with histiocytic sarcoma involving the left femur. The tumor rapidly responded to a combination of cladribine and high-dose cytosine arabinoside, an aggressive salvage regimen for refractory Langerhans cell histiocytosis, and became impalpable during the first cycle. The patient has remained in complete remission more than 7 years from diagnosis.
authors.affiliation: Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuou-ku, Niigata, Niigata, 951-8510, Japan.
authors.forename: Haruko
authors.initials: H
authors.lastname: Iwabuchi
authors.affiliation: Department of Orthopedic Surgery, Niigata University Graduate School Medical and Dental Sciences, Niigata, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawashima
authors.affiliation: Department of Pathology, Niigata University Graduate School Medical and Dental Sciences, Niigata, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Umezu
authors.affiliation: Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuou-ku, Niigata, Niigata, 951-8510, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takachi
authors.affiliation: Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuou-ku, Niigata, Niigata, 951-8510, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Imamura
authors.affiliation: Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuou-ku, Niigata, Niigata, 951-8510, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Saitoh
authors.affiliation: Department of Orthopedic Surgery, Niigata University Graduate School Medical and Dental Sciences, Niigata, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ogose
authors.affiliation: Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuou-ku, Niigata, Niigata, 951-8510, Japan. chihaya@med.niigata-u.ac.jp.
authors.forename: Chihaya
authors.identifier: http://orcid.org/0000-0001-7435-3464
authors.initials: C
authors.lastname: Imai
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D017338:Cladribine / Q000008:administration & dosage / Q000009:adverse effects; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D054747:Histiocytic Sarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D049268:Positron-Emission Tomography; D012074:Remission Induction; D016879:Salvage Therapy; D016896:Treatment Outcome
chemical_list: D003561:Cytarabine; D017338:Cladribine
keywords: Cladribine; Cytosine arabinoside; Histiocytic sarcoma