title: DNA photonic nanowires with tunable FRET signals on the basis of toehold-mediated DNA strand displacement reactions.
abstract: A DNA photonic nanowire with tunable FRET signals was fabricated on the basis of cascaded toehold-mediated DNA strand displacement reactions. Different DNA inputs were added to trigger the reaction network, and the corresponding FRET signals were obtained. Compared to the direct hybridization, this design is sensitive for 2 nM targets within 20 min and also causes color changes of the solution with blue-light excitation. It could also be applied in live cells to monitor MicroRNA with a simple modification which might become a low-cost method for further application in the future.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China. hjliang@ustc.edu.cn.
authors.forename: Bei
authors.initials: B
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China. hjliang@ustc.edu.cn.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wei
authors.affiliation: Faculty of Material Science and Chemistry, China University of Geosciences, Wuhan 430074, People's Republic of China. huangfj@cug.edu.cn.
authors.forename: Fujian
authors.initials: F
authors.lastname: Huang
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China. hjliang@ustc.edu.cn.
authors.forename: Dongbao
authors.initials: D
authors.lastname: Yao
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China. hjliang@ustc.edu.cn and Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.
authors.forename: Haojun
authors.initials: H
authors.lastname: Liang
mesh_terms: D004247:DNA / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D053770:Nanowires; D009693:Nucleic Acid Hybridization; D017785:Photons
chemical_list: D004247:DNA