title: Tumor growth factor-β is an important factor for immunosuppression and tumorgenesis in Polyoma BK virus infection; a systematic review article.
abstract: Polyoma BK virus (PBK) is a prevalent human specific virus and the cause of several malignancies in human. The main mechanisms used by PBK to induce/stimulate human cancers are yet to be clarified but it has been proposed that PBK may use several mechanisms to induce/stimulate cancers in human including attenuation of immune responses via up-regulation of immunosuppressor molecules. Transforming growth factor beta (TGF-β) is a key multifunctional factor from modulation of immunosurveillance to angiogenesis. The key roles of TGF-β in the progression of Th17 and T regulatory subsets, the most important immune cells involved in development of cancers, have been demonstrated. Thus, this review article aims to describe the mechanisms used by PBK in induction/stimulation of human cancers in TGF-β dependent manner..
authors.affiliation: Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran. Electronic address: a.kariminik@iauk.ac.ir.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Kariminik
authors.affiliation: Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Kheirkhah
mesh_terms: D001739:BK Virus; D063646:Carcinogenesis; D006801:Humans; D007108:Immune Tolerance; D009369:Neoplasms / Q000276:immunology / Q000821:virology*; D027601:Polyomavirus Infections / Q000150:complications*; D016212:Transforming Growth Factor beta / Q000502:physiology*; D014412:Tumor Virus Infections / Q000150:complications*
chemical_list: D016212:Transforming Growth Factor beta
keywords: Polyoma BK associated nephropathy; Polyoma BK virus; T regulatory lymphocytes; TGF-β; Th17; Tumorgenesis