title: [Interferon in combined therapy of human papillomavirus infections associated with sexually transmitted infections. linical observation].
abstract: To investigate the effectiveness of Ingaron (interferon-) in the treatment of HPV infection associated with sexually transmitted infections, the authors analyzed the scientific literature on the association of human papillomavirus infection with other viral and microbial pathogens. A clinical case of the association of human papillomavirus infection, urogenital infections (urogenital chlamydia and genital herpes) and localized scleroderma penis is described. The results of integrated therapy of diseases with the help of Interferon-gamma have been presented. According to the literature, up to 70-80% of HPV infections are associated with microbial (opportunistic, obligate pathogens) and viral infectious agents. Chronic inflammation caused by bacterial and viral associations destroys the immune system and it leads to the ineffectiveness of the therapy. Pathogenic therapy of sexually transmitted infections in combination with interferon-gamma (Ingaron) contributes to the eradication of bacterial pathogens, prevention of viral STI recurrence and elimination of high oncogenic risk types of HPV. Thus, we can reasonably infer that Ingaron (interferon-) alleviates the initial immune disturbances, improves the effectiveness of the treatment and may be recommended for treating HPV infection associated with sexually transmitted infections.
authors.affiliation: FSBE Burnasyan FMBC of the FMBA of Russia, Moscow.
authors.forename: M R
authors.initials: MR
authors.lastname: Rakhmatulina
authors.affiliation: Moscow Regional Clinical Center of Skin and Sexually-Transmitted Diseases, Moscow.
authors.forename: N V
authors.initials: NV
authors.lastname: Bolshenko
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000150:complications / Q000188:drug therapy; D060085:Coinfection; D006558:Herpes Genitalis / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D008297:Male; D052801:Male Urogenital Diseases / Q000150:complications / Q000188:drug therapy; D030361:Papillomavirus Infections / Q000188:drug therapy*; D012594:Scleroderma, Localized / Q000150:complications / Q000188:drug therapy; D015229:Sexually Transmitted Diseases, Viral / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents; D007371:Interferon-gamma
keywords: Ingaron; anogenital warts; chlamydia; genital herpes; human papillomavirus infection; interferon gamma; interferons; localized penile scleroderma