title: In vitro efficacy of a novel potassium oxalate hydrogel for dentin hypersensitivity.
abstract: A novel potassium oxalate-based hydrogel is proposed for treating dentin hypersensitivity and this study evaluates its in vitro performance as a remineralizing, desensitizing agent. Etched disks of human dentin were treated for 10 or 20 min using the test hydrogel, to mimic a professional application with dental mouth guards. Dentin disks were evaluated in terms of permeability indexes in a fluid-filled system, the surface morphology was assessed by scanning electron microscopy, and the structural properties were studied using X-ray diffraction analysis. The potassium oxalate hydrogel significantly reduced dentin permeability, in a time-dependent manner, and occluded most of the patent dentinal tubules via crystal precipitation, forming a remineralized layer. After hydrogel treatments, an acid solution (pH 4.2) was applied to the disks for 30 s, or 1, 2, or 5 min, in order to reproduce a plaque-like oral acidity, and further analysis showed a good resistance of the remineralized layer to the acid challenge. The potassium oxalate-based hydrogel showed a better performance over commercially available products and artificial saliva, appearing a promising candidate for the treatment of dentin hypersensitivity.
authors.affiliation: Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Milano, Italy.|Dipartimento di Scienze della Salute, Università del Piemonte Orientale 'A. Avogadro', Novara, Italy.
authors.forename: Elena M
authors.initials: EM
authors.lastname: Varoni
authors.affiliation: Department of Civil, Chemical, Environmental and Materials Engineering, Università degli Studi di Bologna, Bologna, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Zuccheri
authors.affiliation: Dipartimento di Scienze della Salute, Università del Piemonte Orientale 'A. Avogadro', Novara, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Carletta
authors.affiliation: Department of Engineering for Innovation, Università del Salento, Lecce, Italy.|Ghimas, c/o Dhitech S.C.A.R.L., Campus Ecotekne, Lecce, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Palazzo
authors.affiliation: Dipartimento di Scienze della Salute, Università del Piemonte Orientale 'A. Avogadro', Novara, Italy.|Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali, Firenze, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Cochis
authors.affiliation: Department of Civil, Chemical, Environmental and Materials Engineering, Università degli Studi di Bologna, Bologna, Italy.
authors.forename: Martino
authors.initials: M
authors.lastname: Colonna
authors.affiliation: Dipartimento di Scienze della Salute, Università del Piemonte Orientale 'A. Avogadro', Novara, Italy.|Department of Engineering for Innovation, Università del Salento, Lecce, Italy.
authors.forename: Lia
authors.initials: L
authors.lastname: Rimondini
mesh_terms: D057133:Dentin Desensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D003806:Dentin Permeability / Q000187:drug effects; D003807:Dentin Sensitivity / Q000188:drug therapy*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis / Q000494:pharmacology*; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D019815:Oxalic Acid / Q000494:pharmacology*; D012464:Saliva, Artificial / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D057133:Dentin Desensitizing Agents; D012464:Saliva, Artificial; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D019815:Oxalic Acid
keywords: dentin desensitizing agents; dentinal fluid; tooth remineralization