title: Treatment-related determinants of survival in early-stage (T1-2N0M0) oral cavity cancer: A population-based study.
abstract: National guidelines support both surgical and radiotherapy (RT) as initial treatment options for early-stage oral cavity squamous cell carcinoma (SCC). There remains limited data evaluating the survival outcomes of RT and the current practice patterns for these lesions.
  
  
  
  We conducted a retrospective review of 8274 patients in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2008 with T1 to T2N0M0 oral cavity SCC. Primary outcomes were 5-year overall survival (OS) and disease-specific survival (DSS).
  
  
  
  Surgical therapy had significantly improved OS (140 months; p < .001) and DSS (217 months; p < .001) compared to surgery with adjuvant RT (104 and 163 months, respectively) and definitive RT (68 and 136 months, respectively). The use of radiation alone was associated with an increased T classification, hard palate, retromolar trigone primary site lesions, and advanced patient age.
  
  
  
  Primary radiation without surgery continues to be used in a subset of early-stage oral cavity SCCs, in which it is associated with decreased OS and DSS. © 2017 Wiley Periodicals, Inc. Head Neck 39: 876-880, 2017.
authors.affiliation: Division of Otolaryngology - Head and Neck Surgery, The University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Justin C
authors.initials: JC
authors.lastname: Sowder
authors.affiliation: Division of Otolaryngology - Head and Neck Surgery, The University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Cannon
authors.affiliation: Division of Otolaryngology - Head and Neck Surgery, The University of Utah School of Medicine, Salt Lake City, Utah.|The Huntsman Cancer Institute, Salt Lake City, Utah.|Department of Surgery, Division Otolaryngology, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City, Utah.
authors.forename: Luke O
authors.initials: LO
authors.lastname: Buchmann
authors.affiliation: Division of Otolaryngology - Head and Neck Surgery, The University of Utah School of Medicine, Salt Lake City, Utah.|The Huntsman Cancer Institute, Salt Lake City, Utah.
authors.forename: Jason P
authors.initials: JP
authors.lastname: Hunt
authors.affiliation: The Huntsman Cancer Institute, Salt Lake City, Utah.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hitchcock
authors.affiliation: The Huntsman Cancer Institute, Salt Lake City, Utah.
authors.forename: Shane
authors.initials: S
authors.lastname: Lloyd
authors.affiliation: The Huntsman Cancer Institute, Salt Lake City, Utah.
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Grossmann
authors.affiliation: Division of Otolaryngology - Head and Neck Surgery, The University of Utah School of Medicine, Salt Lake City, Utah.|The Huntsman Cancer Institute, Salt Lake City, Utah.|Department of Surgery, Division Otolaryngology, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City, Utah.
authors.forename: Marcus M
authors.initials: MM
authors.lastname: Monroe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D018426:SEER Program; D015996:Survival Rate; D014481:United States / Q000453:epidemiology
keywords: Epidemiology; Surveillance; T1; T2; and End Results (SEER); cancer; early; floor of mouth; hard palate; oral cavity; prognosis; radiation; squamous cell carcinoma; surgery; survival; tongue