title: Medication-Related Osteonecrosis of the Jaw and Dental Implants Failures: A Systematic Review.
abstract: No well-established evidence supporting safe use of bisphosphonates (BPs) or other antiresorptive agents prior, during, or after dentoalveolar surgery, are currently available; moreover, the real risk of osteonecrosis of the jaw (ONJ) development is still unknown. The aim of the present systematic review was to assess the scientific literature concerning the implants placement in antiresorptive agent users and the related risk of implants failure and ONJ development. English papers published from January 2003 until December 2014 were identified on the MEDLINE database. Titles and abstracts retrieved form electronic search were screened separately by 2 examiners; thus, original studies dealing with dental implants placement during or before bone antiresorptive agent therapy and the relative risk of implant failure or development of osteonecrosis were evaluated. Due to the heterogeneity of the included studies and the high risk of bias, there is no evidence of the safe use of oral antiresorptive agents prior or after dental implant surgery. Indeed, implant failure and ONJ development can occur and represent a devastating side effect that should be considered during treatment. Within the limitation of the present systematic review, high quality studies are needed to provide an adequate level of evidence regarding the safety of dentoalveolar surgery during or before bone resorption inhibition therapy and the increase predisposition to osteonecrosis of the jaw (ONJ) development. Therefore, antiresorptive agent therapy should be considered a risk factor until further evidence is prospectively obtained.
authors.affiliation: 1   Department of Neurosciences, University of Padova, Padova, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Guazzo
authors.affiliation: 1   Department of Neurosciences, University of Padova, Padova, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Sbricoli
authors.affiliation: 1   Department of Neurosciences, University of Padova, Padova, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Ricci
authors.affiliation: 1   Department of Neurosciences, University of Padova, Padova, Italy.
authors.forename: Eriberto
authors.initials: E
authors.lastname: Bressan
authors.affiliation: 2   Department of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
authors.forename: Adriano
authors.initials: A
authors.lastname: Piattelli
authors.affiliation: 2   Department of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
authors.forename: Flavia
authors.initials: F
authors.lastname: Iaculli
mesh_terms: D050071:Bone Density Conservation Agents; D015921:Dental Implants; D019232:Dental Restoration Failure; D004164:Diphosphonates; D006801:Humans; D007571:Jaw Diseases; D010020:Osteonecrosis
chemical_list: D050071:Bone Density Conservation Agents; D015921:Dental Implants; D004164:Diphosphonates
keywords: ONJ; antiresorptive drugs; bisphosphonates; dental implants; implant failure