title: Impact of Obesity on Heart and Lung Transplantation: Does Pre-Transplant Obesity Affect Outcomes?
abstract: Increasing prevalence of obesity has led to a rise in the number of prospective obese heart and lung transplant recipients. The optimal management strategy of obese patients with end-stage heart and lung failure remains controversial. This review article discusses and provides a summary of the literature surrounding the impact of obesity on outcomes in heart and lung transplantation. Studies on transplant obesity demonstrate controversy in terms of morbidity and mortality outcomes and obesity pre-transplantation. However, the impact of obesity on outcomes seems to be more consistently demonstrated in lung rather than heart transplantation. The ultimate goal in heart and lung transplantation in the obese patient is to identify those at highest risk of complication that may warrant therapies to mitigate risk by addressing comorbid conditions.
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, AB, Canada; Mazankowski Alberta Heart Institute, Edmonton, AB, Canada.
authors.forename: S J
authors.initials: SJ
authors.lastname: Bozso
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, AB, Canada; Mazankowski Alberta Heart Institute, Edmonton, AB, Canada.
authors.forename: Je
authors.initials: J
authors.lastname: Nagendran
authors.affiliation: Peter Lougheed Centre - Department of Surgery, University of Calgary, Calgary, AB, Canada.
authors.forename: R S
authors.initials: RS
authors.lastname: Gill
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, AB, Canada; Mazankowski Alberta Heart Institute, Edmonton, AB, Canada; Alberta Transplant Institute, Edmonton, AB, Canada; Canadian National Transplant Research Program, Edmonton, AB, Canada.
authors.forename: D H
authors.initials: DH
authors.lastname: Freed
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, AB, Canada; Mazankowski Alberta Heart Institute, Edmonton, AB, Canada; Alberta Transplant Institute, Edmonton, AB, Canada; Canadian National Transplant Research Program, Edmonton, AB, Canada. Electronic address: jayan@ualberta.ca.
authors.forename: Ja
authors.initials: J
authors.lastname: Nagendran
mesh_terms: D058625:End Stage Liver Disease / Q000401:mortality / Q000601:surgery; D006333:Heart Failure / Q000401:mortality / Q000601:surgery; D016027:Heart Transplantation / Q000401:mortality*; D016041:Heart-Lung Transplantation / Q000401:mortality; D006801:Humans; D016040:Lung Transplantation / Q000401:mortality*; D009765:Obesity / Q000150:complications*; D011300:Preoperative Care; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome