title: Underrecognized clinical features of folliculotropic mycosis fungoides: a large clinical series.
abstract: OBJECTIVE
  A rare variant of mycosis fungoides (MF), folliculotropic MF (FMF) is characterized by a broad clinical spectrum that primarily includes follicle-based lesions but also many atypical clinical manifestations. The objective of the present study was to conduct a clinical analysis of patients with FMF, with a particular focus on highlighting underrecognized dermatological features.
  
  
  METHODS
  Overall, 27 FMF patients enrolled in our department';s MF registry, which includes 572 patients, were retrospectively reevaluated with regard to demographics, clinical features, treatment modalities, follow-up, and outcomes.
  
  
  RESULTS
  Besides the well-known clinical features of FMF, we found lichen spinulosus-like lesions in association with hypopigmentation (n = 3) and alopecia (n = 2), infiltrated/elevated erythematous facial plaques initially considered to be lupus tumidus (n = 2), pseudotumoral lesions clinically mimicking tumor-stage MF (n = 1), persistent excoriations (n = 1) and erythematous facial papules mimicking rosacea (n = 1), as well as white dome-shaped asymptomatic papules/nodules filled with mucin (on histology) (n = 2) that overlay other disease-related lesions. Various therapeutic methods were used with variable results. Eight (29.6 %) patients had late-stage disease.
  
  
  CONCLUSIONS
  Awareness of underrecognized clinical manifestations may be key to reducing delayed diagnosis of this aggressive MF variant.
authors.affiliation: Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Can
authors.initials: C
authors.lastname: Baykal
authors.affiliation: Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Tugba
authors.initials: T
authors.lastname: Atci
authors.affiliation: Department of Pathology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Ozturk Sari
authors.affiliation: Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Algun
authors.initials: A
authors.lastname: Polat Ekinci
authors.affiliation: Department of Pathology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Nesimi
authors.initials: N
authors.lastname: Buyukbabani
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002983:Clinical Competence / Q000706:statistics & numerical data*; D003951:Diagnostic Errors / Q000517:prevention & control / Q000706:statistics & numerical data*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D015995:Prevalence; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D055815:Young Adult