title: Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease.
abstract: Peroxiredoxin 3 (PRX3) is a mitochondrial antioxidant that regulates apoptosis in various cancers. However, whether tubular PRX3 predicts recovery of renal function following acute kidney injury (AKI) remains unknown. This retrospective cohort study included 54 hospitalized patients who had AKI with biopsy-proven acute tubular necrosis (ATN). The study endpoint was renal function recovery within 6 months. Of the 54 enrolled patients, 25 (46.3%) had pre-existing chronic kidney disease (CKD) and 33 (61%) recovered renal function. Tubular PRX3 expression was higher in patients with ATN than in those without renal function recovery. The level of tubular but not glomerular PRX3 expression predicted renal function recovery from AKI (AUROC = 0.76). In multivariate Cox regression analysis, high PRX3 expression was independently associated with a higher probability of renal function recovery (adjusted hazard ratio = 8.99; 95% CI 1.13-71.52, P = 0.04). Furthermore, the discriminative ability of the clinical model for AKI recovery was improved by adding tubular PRX3. High tubular PRX3 expression was associated with a higher probability of renal function recovery from ATN. Therefore, tubular PRX3 in combination with conventional predictors can further improve recovery prediction and may help with risk stratification in AKI patients with pre-existing CKD.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.|Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.|School of Medicine, Chung-Shan Medical University, Taichung, Taiwan.|Internal Medicine Research Center, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Chia-Lin
authors.initials: CL
authors.lastname: Wu
authors.affiliation: Department of Pathology, Changhua Christian Hospital, Taipei, Taiwan.
authors.forename: Tzu-Cheng
authors.initials: TC
authors.lastname: Su
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.|School of Medicine, Chung-Shan Medical University, Taichung, Taiwan.|Internal Medicine Research Center, Changhua Christian Hospital, Changhua, Taiwan.|Environmental and Precision Medicine Laboratory, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Chia-Chu
authors.initials: CC
authors.lastname: Chang
authors.affiliation: Internal Medicine Research Center, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Chew-Teng
authors.initials: CT
authors.lastname: Kor
authors.affiliation: Environmental and Precision Medicine Laboratory, Changhua Christian Hospital, Changhua, Taiwan.|Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli County, Taiwan.
authors.forename: Chung-Ho
authors.initials: CH
authors.lastname: Chang
authors.affiliation: Environmental and Precision Medicine Laboratory, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Tao-Hsiang
authors.initials: TH
authors.lastname: Yang
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.|School of Medicine, Chung-Shan Medical University, Taichung, Taiwan.
authors.forename: Ping-Fang
authors.initials: PF
authors.lastname: Chiu
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.|Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.|Department and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Der-Cherng
authors.initials: DC
authors.lastname: Tarng
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D001706:Biopsy; D015897:Comorbidity; D005260:Female; D015870:Gene Expression; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests; D007683:Kidney Tubular Necrosis, Acute / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism* / Q000401:mortality; D007684:Kidney Tubules / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D061105:Peroxiredoxin III / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D016016:Proportional Hazards Models; D012372:ROC Curve; D020127:Recovery of Function; D051436:Renal Insufficiency, Chronic / Q000150:complications*
chemical_list: D015415:Biomarkers; D061105:Peroxiredoxin III