title: Successful Pregnancies and Deliveries in a Patient With Evolving Hypopituitarism due to Pituitary Stalk Transection Syndrome: Role of Growth Hormone Replacement.
abstract: We herein report a 31-year-old Japanese woman with evolving hypopituitarism due to pituitary stalk transection syndrome. She had a history of short stature treated with growth hormone (GH) in childhood and had hypothyroidism and primary amenorrhea at 20 years old. Levothyroxine replacement and recombinant follicle stimulating hormone-human chorionic gonadotropin (FSH-hCG) therapy for ovulation induction were started. GH replacement therapy (GHRT) was resumed when she was 26 years old. She developed mild adrenocortical insufficiency at 31 years old. She succeeded in becoming pregnant and delivered twice. GHRT was partially continued during pregnancy and stopped at the end of the second trimester without any complications.
authors.affiliation: Department of Endocrinology and Metabolism, Kurobe City Hospital, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Yoshizawa
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Ieki
authors.forename: Eisuke
authors.initials: E
authors.lastname: Takazakura
authors.forename: Kaori
authors.initials: K
authors.lastname: Fukuta
authors.forename: Takao
authors.initials: T
authors.lastname: Hidaka
authors.forename: Takanobu
authors.initials: T
authors.lastname: Wakasugi
authors.forename: Akira
authors.initials: A
authors.lastname: Shimatsu
mesh_terms: D000328:Adult; D036861:Delivery, Obstetric; D004334:Drug Administration Schedule; D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods; D019382:Human Growth Hormone / Q000008:administration & dosage / Q000172:deficiency / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy* / Q000209:etiology; D007037:Hypothyroidism / Q000150:complications; D010062:Ovulation Induction / Q000379:methods; D018743:Perinatal Care / Q000379:methods; D010902:Pituitary Gland / Q000293:injuries*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011262:Pregnancy Trimester, Second; D013577:Syndrome; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D019382:Human Growth Hormone; D013974:Thyroxine