title: An atypical case of recurrent carotid body carcinoma in a young adult dog: Histopathological, immunohistochemical and electron microscopic study.
abstract: A 3.5-year-old female Chihuahua was presented with complaint of neck pain, intermittent cough and dysphagia. Physical examination and diagnostic imaging of neck region revealed a solid and highly vascularized mass involving the retropharyngeal region. Histologically, the mass showed an atypical zellballen pattern which comprised of high density of type I chief cells with high nuclear cytoplasmic ratio and separated by delicate fibrovascular stroma. Immunoreactivity for neuroendocrine markers was diffusely positive in cytoplasm of tumor cells. Disseminated tumor emboli in external jugular vein were detected 6 months after initial surgery. An electron microscopic study revealed numerous electron-dense intracytoplasmic neurosecretory granules. Based on these findings, carotid body carcinoma was diagnosed.
authors.affiliation: Laboratory of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Gakuen-kibanadai-nishi-1-1, Miyazaki 889-2192, Japan.
authors.forename: Angeline Ping Ping
authors.initials: AP
authors.lastname: Teh
authors.forename: Watanyoo
authors.initials: W
authors.lastname: Pratakpiriya
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hidaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sato
authors.forename: Takuya
authors.initials: T
authors.lastname: Hirai
authors.forename: Ryoji
authors.initials: R
authors.lastname: Yamaguchi
mesh_terms: D000818:Animals; D018278:Carcinoma, Neuroendocrine / Q000473:pathology*; D002344:Carotid Body; D002345:Carotid Body Tumor / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*