title: Pattern of care in operable endometrial cancer treated at a rural-based tertiary care cancer center.
abstract: OBJECTIVE
  An audit was planned to study the demographics, staging, treatment details, and outcomes of operable endometrial cancers.
  
  
  METHODS
  All operable endometrial cancers treated between January 2009 and October 2014 were included in the study. The details regarding demographics, staging, surgical procedure, pathological staging, adjuvant treatment, and outcomes were extracted from the case records. Descriptive statistics was performed. The time-to-event analysis was done by Kaplan-Meier method. Univariate and multivariate analyses were done for disease-free survival (DFS) and overall survival (OS).
  
  
  RESULTS
  There were 55 patients with a median age of 59 years (35-73 years). The Eastern Cooperative Oncology Group performance status was 1 in 52 patients (94.5%) and 2 in 3 patients (5.5%). Forty-nine patients (89.1%) had disease restricted to endometrium while 6 patients (10.9%) had cervical involvement. The surgery done was Type I hysterectomy in 49 patients (89.1%), Type II in 5 patients (9.1%), and Type III in 1 patient (1.8%). Pelvic lymph node dissection was done in all patients while para-aortic (infrahilar) dissection was done in 48 patients (87.3%). The pathological stages were Stage IA in 19 patients, Stage IB in 15 patients, Stage II in 4 patients, Stage IIIA in 3 patients, Stage IIIB in 2 patients, Stage IIIC1 in 5 patients, Stage IIIC2 in 4 patients, and Stage IV in 3 patients. Grade 1 tumors were seen in 23 patients, Grade 2 in 13 patients, and Grade 3 in 19 patients. The histology was endometrioid in 44 patients, serous in 6 patients, clear cell in 3 patients, and others in 2 patients. Adjuvant treatment was received by 40 patients. With a median follow-up of 2.5 years, the 3-year DFS and OS were 78% and 82%, respectively. Age >59 years, Stage III or greater, and Grade 3 tumors were independent prognostic factors adversely affecting both DFS and OS.
  
  
  CONCLUSIONS
  The outcomes in our study are comparable to that seen in Western literature. Elderly status, higher stage, and a poorly differentiated tumor are associated with poor outcomes.
authors.affiliation: Department of Surgical Oncology, Malabar Cancer Center, Kannur, Kerala, India.
authors.forename: S B
authors.initials: SB
authors.lastname: Dessai
authors.affiliation: Department of Surgical Oncology, Malabar Cancer Center, Kannur, Kerala, India.
authors.forename: D
authors.initials: D
authors.lastname: Adrash
authors.affiliation: Department of Radiation Oncology, Malabar Cancer Center, Kannur, Kerala, India.
authors.forename: M
authors.initials: M
authors.lastname: Geetha
authors.affiliation: Department of Clinical Laboratory Services and Translational Research, Division of Oncopathology, Malabar Cancer Center, Kannur, Kerala, India.
authors.forename: S
authors.initials: S
authors.lastname: Arvind
authors.affiliation: Department of Surgical Oncology, Malabar Cancer Center, Kannur, Kerala, India.
authors.forename: J
authors.initials: J
authors.lastname: Bipin
authors.affiliation: Department of Clinical Laboratory Services and Translational Research, Division of Oncopathology, Malabar Cancer Center, Kannur, Kerala, India.
authors.forename: S
authors.initials: S
authors.lastname: Nayanar
authors.affiliation: Department of Surgical Oncology, Malabar Cancer Center, Kannur, Kerala, India.
authors.forename: K
authors.initials: K
authors.lastname: Sachin
authors.affiliation: Department of Palliative Medicine, Malabar Cancer Center, Kannur, Kerala, India.
authors.forename: M S
authors.initials: MS
authors.lastname: Biji
authors.affiliation: Department of Surgical Oncology, Malabar Cancer Center, Kannur, Kerala, India.
authors.forename: S
authors.initials: S
authors.lastname: Balasubramanian
mesh_terms: D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D016889:Endometrial Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007194:India; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D019035:Rural Health Services; D062606:Tertiary Care Centers