title: [Effect of Rigorous Staging at the First Diagnosis on Prognosis of Patients with Follicular Lymphoma].
abstract: BACKGROUND
  A survey of early stage follicular lymphoma(FL) revealed that the rigorously staged FL patients at first diagnosis had a better outcome as compared with non-rigorous staged FL patients, but there were no similar reports in China.
  
  
  OBJECTIVE
  To explore the relationship between the rigorous staging at first diagnosis and the prognosis of FL patients at different stages.
  
  
  METHODS
  The clinical data of 111 patients with newly diagnosed FL from 2008 to 2014 year were collected and analyzed. The rigorous staging included: (1) bone marrow aspiration and biopsy, (2) imaging examination of whole body including CT and ultrasounic scan, or PET/CT, either or both is defined as rigorous staging, or else as non-rigorous staging.
  
  
  RESULTS
  The FL patients at I-II stages by rigorous staging showed a superior progression-free survival(PFS) compared with non-rigorous staging patients(P=0.048). For all the patients, the age, serum LDH, bone marrow lesion and more than 3 foci of diameter larger than 3 cm correlated with prognosis in univariate analysis, and multivariate analysis revealed that the age, serum LDH and bone marrow imolvement were the independent prognostic factors.
  
  
  CONCLUSIONS
  Rigorous staging leads to better outcomes, suggesting that accurate and appropriate testing is important for the patients at the first treatment. The close correlation of bone marrow with prognosis indicates that the evaluation of bone marrow is very important for the daily clinical practice.
authors.affiliation: Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Yan
authors.affiliation: Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
authors.forename: Ya-Fei
authors.initials: YF
authors.lastname: Wang
authors.affiliation: Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Yang
authors.affiliation: Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Zhao
authors.affiliation: Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Xiao-Xiong
authors.initials: XX
authors.lastname: Wu
authors.affiliation: Department of Hematology, The Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Wan-Ming
authors.initials: WM
authors.lastname: DA
authors.affiliation: Department of Hematology, The Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Su-Xia
authors.initials: SX
authors.lastname: Li
authors.affiliation: Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China. E-mail: yizhuozhang111@163.com.
authors.forename: Yi-Zhuo
authors.initials: YZ
authors.lastname: Zhang
mesh_terms: D002681:China; D006801:Humans; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000473:pathology; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography; D011379:Prognosis; D012189:Retrospective Studies