title: Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors.
abstract: Five new non-steroidal inhibitors for cytochrome P450 17A1 (CYP17A1) were identified by structure-based optimisation from a recently identified selective CYP17A1 inhibitor. The compounds are nanomolar inhibitors of steroidogenesis measured in recombinant CYP17A1 and in H295R cells.
authors.affiliation: Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen, Denmark. fsj@sund.ku.dk.
authors.forename: Morten
authors.initials: M
authors.lastname: Larsen
authors.affiliation: Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
authors.forename: Cecilie H
authors.initials: CH
authors.lastname: Hansen
authors.affiliation: Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
authors.forename: Tobias B
authors.identifier: http://orcid.org/0000-0003-0531-8504
authors.initials: TB
authors.lastname: Rasmussen
authors.affiliation: Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
authors.forename: Julie
authors.initials: J
authors.lastname: Islin
authors.affiliation: Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
authors.forename: Bjarne
authors.initials: B
authors.lastname: Styrishave
authors.affiliation: Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen, Denmark. fsj@sund.ku.dk.
authors.forename: Lars
authors.identifier: http://orcid.org/0000-0002-7607-7130
authors.initials: L
authors.lastname: Olsen
authors.affiliation: Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen, Denmark. fsj@sund.ku.dk.
authors.forename: Flemming Steen
authors.identifier: http://orcid.org/0000-0001-8040-2998
authors.initials: FS
authors.lastname: Jørgensen