title: Relationships between urinary electrolytes excretion and central hemodynamics, and arterial stiffness in hypertensive patients.
abstract: High sodium intake plays an important role in the onset and exacerbation of hypertension. However, the relationships between urinary electrolytes excretion and central hemodynamics and between urinary electrolyte excretion and arterial stiffness are still the subject of debate. This study sought to clarify the associations of salt intake with central aortic pressure and arterial stiffness indicators. A total of 431 untreated hypertensive individuals were recruited into the study. Twenty-four-hour urinary samples were collected to measure the excretion of urinary electrolytes. Central hemodynamics parameters and brachial-ankle pulse wave velocity (baPWV) were measured. We evaluated the independent relationship between urinary sodium or potassium excretion and the abovementioned indices. The mean 24-h urinary sodium of all subjects was 166.6±70.0 mmol/24 h. With increases in urinary sodium excretion, central blood pressure and baPWV values markedly increased. Multiple regression analysis showed that urinary sodium was independently associated with increases in central systolic blood pressure, central diastolic blood pressure, the augmentation index, and baPWV. Significant correlations were identified between high dietary sodium and central hemodynamics and between high dietary sodium and arterial elasticity. Prospective interventional studies in hypertensive patients may be required to determine the effect of salt intake on central hemodynamics.
authors.affiliation: Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: Weizhong
authors.initials: W
authors.lastname: Han
authors.affiliation: Department of Shandong Cancer Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Heart Center, Hypertensive Laboratory, Peking University People's Hospital, Beijing, China.
authors.forename: Ningling
authors.initials: N
authors.lastname: Sun
authors.affiliation: Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: Yunchao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: Shiliang
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D055109:Ankle Brachial Index; D001794:Blood Pressure; D004573:Electrolytes / Q000652:urine*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000503:physiopathology* / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000652:urine; D011446:Prospective Studies; D012964:Sodium / Q000652:urine; D012982:Sodium, Dietary / Q000009:adverse effects; D059289:Vascular Stiffness
chemical_list: D004573:Electrolytes; D012982:Sodium, Dietary; D012964:Sodium; D011188:Potassium