title: Computationally Aided Absolute Stereochemical Determination of Enantioenriched Amines.
abstract: A simple and efficient protocol for sensing the absolute stereochemistry and enantiomeric excess of chiral monoamines is reported. Preparation of the sample requires a single-step reaction of the 1,1'-(bromomethylene)dinaphthalene (BDN) with the chiral amine. Analysis of the exciton coupled circular dichroism generated from the BDN-derivatized chiral amine sample, along with comparison to conformational analysis performed computationally, yields the absolute stereochemistry of the parent chiral monoamine.
authors.affiliation: Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United States.
authors.forename: Jun
authors.identifier: 0000-0002-9986-0312
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United States.
authors.forename: Hadi
authors.initials: H
authors.lastname: Gholami
authors.affiliation: Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United States.
authors.forename: Xinliang
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United States.
authors.forename: Minji
authors.initials: M
authors.lastname: Chun
authors.affiliation: Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United States.
authors.forename: Chrysoula
authors.initials: C
authors.lastname: Vasileiou
authors.affiliation: Graduate School of Integrated Arts and Sciences, Hiroshima University , Higashi, Hiroshima 739-8521, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nehira
authors.affiliation: Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United States.
authors.forename: Babak
authors.identifier: 0000-0002-3193-0732
authors.initials: B
authors.lastname: Borhan