title: Factors influencing cardiometabolic risk profile in patients with psoriasis.
abstract: BACKGROUND
  Psoriasis has been associated with metabolic syndrome and with an increased cardiovascular risk especially in patients with severe disease. The goal of this study was to estimate the prevalence of metabolic syndrome and other cardiovascular risk factors and its association with the psoriasis severity, sex and age.
  
  
  METHODS
  Consecutive patients with psoriasis were enrolled in a prospective study over a 1-year period. Blood samples were collected. Psoriasis area and severity index (PASI) and body surface area scores and two dermatology quality of life (DQOL) questionnaires were used to evaluate psoriasis severity and the impact of the disease.
  
  
  RESULTS
  Altogether 178 patients were included, of whom 44% had moderate-severe psoriasis. The overall prevalence of metabolic syndrome was 30% (men 34%, women 26%) without significant differences between patients with severe and mild disease. Age and menopause appeared to increase the risk for metabolic syndrome. Patients with severe psoriasis smoked more heavily, were more likely to have diabetes or insulin resistance and had higher homocysteine and lower high density lipoprotein cholesterol (HDL-C) levels than patients with mild psoriasis (P < 0.05). In women, a higher waist circumference was observed. Women had higher HDL-C levels and lower smoking and alcohol consumption rates. In accordance with the systematic coronary risk evaluation system, 18% of the patients had a high 10-year risk of fatal cardiovascular disease.
  
  
  CONCLUSIONS
  Psoriasis severity was associated with diabetes, insulin-resistance, smoking habit and higher cardiovascular risk. Metabolic syndrome was related to age and menopause but not to psoriasis severity.
authors.affiliation: Department of Dermatology, Hospital Universitari Mútua Terrassa, Barcelona, Spain.
authors.forename: Neus
authors.initials: N
authors.lastname: Curcó
authors.affiliation: Department of Dermatology, Hospital Universitari Mútua Terrassa, Barcelona, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Barriendos
authors.affiliation: Department of Endocrinology, Hospital Universitari Mútua Terrassa, Barcelona, Spain.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Barahona
authors.affiliation: Department of Dermatology, Hospital Universitari Mútua Terrassa, Barcelona, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Arteaga
authors.affiliation: Department of Dermatology, Hospital Universitari Mútua Terrassa, Barcelona, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: García
authors.affiliation: Department of Dermatology, Hospital Universitari Mútua Terrassa, Barcelona, Spain.
authors.forename: Stanislav
authors.initials: S
authors.lastname: Yordanov
authors.affiliation: Department of Dermatology, Hospital Universitari Mútua Terrassa, Barcelona, Spain.
authors.forename: Olimpia
authors.initials: O
authors.lastname: De La Barrera
authors.affiliation: Department of Dermatology, Hospital Universitari Mútua Terrassa, Barcelona, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Prat
authors.affiliation: Department of Dermatology, Hospital Universitari Mútua Terrassa, Barcelona, Spain.
authors.forename: Pere
authors.initials: P
authors.lastname: Vives
authors.affiliation: Research Unit, Mútua Terrassa Research Foundation, University of Barcelona, Barcelona, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Giménez
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001830:Body Surface Area; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D008076:Cholesterol, HDL / Q000097:blood; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008593:Menopause; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D011565:Psoriasis / Q000453:epidemiology*; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking / Q000453:epidemiology; D013030:Spain / Q000453:epidemiology; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D006710:Homocysteine
keywords: cardiovascular risk comorbidity; metabolic syndrome; psoriasis