title: Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE).
abstract: Neuropathic pain is a neurological disorder that strongly affects the quality of life of patients. The molecular and cellular mechanisms at the basis of the neuropathic pain establishment still need to be clarified. Among the neuromodulators that play a role in the pathological pain pathways, endocannabinoids could be deeply involved in both neuronal and non-neuronal mechanisms responsible for the appearance of tactile allodynia. Indeed, the function and dysfunction of this complex system in the molecular and cellular mechanisms of chronic pain induction and maintenance have been widely studied over the last two decades. In this review article, we highlighted the possible modulation of the endocannabinoid system in the neuronal, glial and microglial modulation in neuropathic pain treatment.
authors.affiliation: Department of Experimental Medicine, Division of Pharmacology, Università della Campania "L. Vanvitelli", Via Costantinopoli 16, Naples, Italy; Endocannabinoid Research Group, Pozzuoli, Italy; Young Against Pain (YAP) Italian Group, Italy. Electronic address: livio.luongo@gmail.com.
authors.forename: Livio
authors.initials: L
authors.lastname: Luongo
authors.affiliation: Pain Pathophysiology Lab, Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland; Endocannabinoid Research Group, Pozzuoli, Italy.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Starowicz
authors.affiliation: Department of Experimental Medicine, Division of Pharmacology, Università della Campania "L. Vanvitelli", Via Costantinopoli 16, Naples, Italy; Endocannabinoid Research Group, Pozzuoli, Italy.
authors.forename: Sabatino
authors.initials: S
authors.lastname: Maione
authors.affiliation: Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy; Endocannabinoid Research Group, Pozzuoli, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Marzo
mesh_terms: D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D063385:Cannabinoid Receptor Modulators / Q000494:pharmacology / Q000627:therapeutic use; D002186:Cannabinoids / Q000378:metabolism*; D063388:Endocannabinoids / Q000378:metabolism*; D006801:Humans; D006930:Hyperalgesia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D058990:Molecular Targeted Therapy / Q000379:methods; D009437:Neuralgia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D000700:Analgesics; D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids; D063388:Endocannabinoids
keywords: Astrocytes; Cannabinoid system; Endocannabinoids; Microglia; Neuropathic pain