title: Effects ofHGFgene polymorphisms and protein expression on transhepatic arterial chemotherapeutic embolism efficacy and prognosis in patients with primary liver cancer.
abstract: OBJECTIVE
  To investigate the correlations of two hepatocyte growth factor (HGF) gene polymorphisms (rs5745652 and rs2074725) and their protein expression levels with the efficacy of transhepatic arterial chemotherapeutic embolism (TACE) and prognosis in patients with primary liver cancer (PLC).
  
  
  METHODS
  From March 2011 to June 2012, 109 PLC patients (the case group) who chose TACE as primary treatment and 80 healthy people (the control group) who had undergone physical examination in The First Affiliated Hospital, Zhejiang University were selected during the same period. Gene polymorphisms ofHGFrs5745652 andHGFrs2074725 were detected. Serum HGF level, treating efficacy, survival quality, and 3-year survival rate for PLC patients who received TACE were observed.
  
  
  RESULTS
  There were significant differences in genotype and allele frequencies ofHGFrs5745652 andHGFrs2074725, between the case and control groups (allP<0.05). Compared with CT+TT genotype ofHGFrs5745652, patients carrying CC genotype had lower serum HGF levels, higher efficacy, better survival quality, and prolonged 3-year survival rate (allP<0.05). In rs2074725, patients carrying CA+AA genotype had lower serum HGF levels, higher efficacy, better survival quality, and prolonged 3-year survival rate compared with patients carrying rs2074725 CC genotype (allP<0.05). Gene polymorphisms ofHGFrs5745652 andHGFrs2074725, tumor size, and Barcelona Clinic Liver Cancer stage were independent prognostic factors for PLC (P<0.05).
  
  
  CONCLUSIONS
  Our results indicated thatHGFgene polymorphisms affect TACE efficacy and survival quality of PLC patients. Patients withHGFCC genotype of rs5745652 and CA+AA genotype of rs2074725 had decreased HGF level, better curative effect, high survival quality, and a good prognosis after TACE treatment.
authors.affiliation: Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases.
authors.forename: Hai-Yong
authors.initials: HY
authors.lastname: Chen
authors.affiliation: Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Yao-Min
authors.initials: YM
authors.lastname: Chen
authors.affiliation: Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases.
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases.
authors.forename: Fu-Chun
authors.initials: FC
authors.lastname: Yang
authors.affiliation: Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Lv
authors.affiliation: Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases.
authors.forename: Yi-Gang
authors.initials: YG
authors.lastname: Qian
authors.affiliation: Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases.
authors.forename: Shu-Sen
authors.initials: SS
authors.lastname: Zheng
keywords: HGF; TACE efficacy; gene polymorphisms; hepatocyte growth factor; primary liver cancer; rs2074725; rs5745652; transhepatic arterial chemotherapeutic embolism efficacy