title: Effect of Sulfation and Molecular Weight on Anticoagulant Activity of Dextran.
abstract: Sulfation (to 2.8) of dextrans with molecular weight of 150 and 20 kDa was followed by the appearance of anticoagulant activity that increased with decreasing their molecular weight and did not depend on antithrombin, plasma inhibitor of serine proteases of the blood coagulation system. Antithrombin activity of dextran sulfate with a molecular weight of 20 kDa reached 12.6-15.3 U/mg. Dextran sulfates with molecular weights of 20 and 150 kDa did not potentiate ADP-induced human platelet aggregation.
authors.affiliation: National Research Center for Hematology, Ministry of Health of the Russian Federation, Moscow, Russia. nndrozd@mail.ru.
authors.forename: N N
authors.initials: NN
authors.lastname: Drozd
authors.affiliation: National Research Center for Hematology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: Yu S
authors.initials: YS
authors.lastname: Logvinova
authors.affiliation: Institute of Chemistry, Komi Science Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Torlopov
authors.affiliation: Institute of Chemistry, Komi Science Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Udoratina
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000925:Anticoagulants / Q000737:chemistry* / Q000494:pharmacology; D000990:Antithrombin III / Q000037:antagonists & inhibitors / Q000378:metabolism; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects; D016264:Dextran Sulfate / Q000494:pharmacology*; D003911:Dextrans / Q000737:chemistry* / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D008970:Molecular Weight; D010974:Platelet Aggregation / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000925:Anticoagulants; D003911:Dextrans; D000244:Adenosine Diphosphate; D000990:Antithrombin III; D006493:Heparin; D016264:Dextran Sulfate
keywords: anticoagulant activity; dextran; dextran sulfate