title: Association between Low-density lipoprotein cholesterol and occipital periventricular hyperintensities in a group of Chinese patients: an observational study.
abstract: BACKGROUND
  While occipital periventricular hyperintensities (OPVHs) are among the most common mild white matter hyperintensities, the clinical factors associated with OPVHs remain unclear. In this study, we investigated the role of clinical factors in development of pure OPVHs.
  
  
  METHODS
  This study included 97 patients with OPVHs and 73 healthy controls. Univariate analysis of clinical factors in OPVH patients and controls was followed by binomial logistic regression analysis to identify clinical factors significantly associated with OPVHs.
  
  
  RESULTS
  Univariate analysis indicated that age, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein-B (Apo-B) levels differed significantly between the OPVH patients and controls (p < 0.05). Age and gender were correlated with OPVH scores (p < 0.05), while LDL-C, triglycerides, Apo-B and TC were anti-correlated with OPVHs scores (p < 0.05). Multivariate analysis indicated that LDL-C is negatively correlated with OPVHs (p < 0.05), and age is positively correlated with OPVHs (p < 0.001).
  
  
  CONCLUSIONS
  In summary, LDL-C was negatively and age was positively associated with OPVHs among Chinese patients in a hospital.
authors.affiliation: Department of Neurology, Xinqiao Hospital, Third Military Medical University, No. 183, Xinqiao Street, Chongqing, 400037, China. ddz92@163.com.
authors.forename: Dazhi
authors.initials: D
authors.lastname: Duan
authors.affiliation: Department of Neurology, Xinqiao Hospital, Third Military Medical University, No. 183, Xinqiao Street, Chongqing, 400037, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Radiology, Xinqiao Hospital, Third Military Medical University, No. 183, Xinqiao Street, Chongqing, 400037, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Cui
authors.affiliation: Department of Radiology, Xinqiao Hospital, Third Military Medical University, No. 183, Xinqiao Street, Chongqing, 400037, China.
authors.forename: Tongsheng
authors.initials: T
authors.lastname: Shu
authors.affiliation: Department of Neurology, Xinqiao Hospital, Third Military Medical University, No. 183, Xinqiao Street, Chongqing, 400037, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000367:Age Factors; D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood*; D006801:Humans; D008279:Magnetic Resonance Imaging; D015999:Multivariate Analysis; D009778:Occipital Lobe / Q000473:pathology*
chemical_list: D008078:Cholesterol, LDL
keywords: Cardiovascular risk factor; Low-density lipoprotein cholesterol; MRI; Occipital periventricular hyperintensities; White matter hyperintensity