title: Effect of tadalafil administration on insulin secretion and insulin sensitivity in obese men.
abstract: OBJECTIVE
  To evaluate the effect of tadalafil administration on insulin secretion and insulin sensitivity in obese men without diabetes.
  
  
  METHODS
  A randomized, double-blind, placebo-controlled clinical trial was carried out in obese male patients between 30 and 50 years of age. Eighteen subjects were randomly assigned to two groups of nine patients each. During a 28-day period, subjects received 5 mg orally of tadalafil or placebo each night. Patients were evaluated before and after the intervention. Total insulin secretion and first phase of insulin secretion were calculated by insulinogenic index and Stumvoll index, respectively, and insulin sensitivity was calculated using the Matsuda index. Tolerability and compliance were evaluated permanently throughout the study.
  
  
  RESULTS
  There were no significant differences after administration of tadalafil in total insulin secretion (0.82 ± 0.45 vs. 0.61 ± 0.27, p = 0.594), first phase of insulin secretion (1332 ± 487 vs. 1602 ± 800, p = 0.779) and insulin sensitivity (4.6 ± 1.2 vs. 4.9 ± 2.5, p = 0.779). No significant differences were shown in other measurements.
  
  
  CONCLUSIONS
  Tadalafil administration for 28 days did not modify insulin secretion or insulin sensitivity in obese men.
authors.affiliation: a Institute of Experimental and Clinical Therapeutics, Physiology Department , Health Science University Center, University of Guadalajara , Guadalajara , Mexico.
authors.forename: Manuel
authors.initials: M
authors.lastname: González-Ortiz
authors.affiliation: a Institute of Experimental and Clinical Therapeutics, Physiology Department , Health Science University Center, University of Guadalajara , Guadalajara , Mexico.
authors.forename: Esperanza
authors.initials: E
authors.lastname: Martínez-Abundis
authors.affiliation: a Institute of Experimental and Clinical Therapeutics, Physiology Department , Health Science University Center, University of Guadalajara , Guadalajara , Mexico.
authors.forename: Diana M
authors.initials: DM
authors.lastname: Hernández-Corona
authors.affiliation: a Institute of Experimental and Clinical Therapeutics, Physiology Department , Health Science University Center, University of Guadalajara , Guadalajara , Mexico.
authors.forename: Alejandra M
authors.initials: AM
authors.lastname: Ramírez-Rodríguez
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D058986:Phosphodiesterase 5 Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000068581:Tadalafil / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D007328:Insulin; D058986:Phosphodiesterase 5 Inhibitors; D000068581:Tadalafil
keywords: Glucose metabolism; Insulin secretion; Insulin sensitivity; Obesity; Tadalafil