title: Surgical resection and vascularized bone reconstruction in advanced stage medication-related osteonecrosis of the jaw.
abstract: A retrospective review of all patients with stage 3 medication-related osteonecrosis of the jaw (MRONJ), treated by surgical resection and immediate vascularized bone reconstruction at a tertiary care medical center, was performed. Eleven patients were included, seven female and four male; their mean age was 65.8 years (range 56-73 years). Mean follow-up was 25 months. Ten patients had received intravenous bisphosphonates. The most common pathology was breast cancer (4/11). Pain (n=8) and pathological fracture (n=7) were the most common presenting symptoms. Microvascular free flaps consisted of seven fibula osteocutaneous flaps and four scapula osteocutaneous free flaps. All patients reported resolution of symptoms, with complete bone union identified radiographically (100%). Complications occurred in three patients (27%). One patient required removal of hardware at 8 months postoperative. Dental implant rehabilitation was completed in two patients. Ten patients are tolerating an oral diet. Ten patients are alive without evidence of MRONJ at any of the surgical sites. One patient died 28 months after surgery from progression of metastatic disease. Advanced MRONJ can be successfully treated in patients using vascularized tissue transfer, including those patients with significant peripheral vascular disease. Dental rehabilitation is a viable option for advanced MRONJ patients treated by vascularized flap reconstruction.
authors.affiliation: Oral-Head and Neck Surgery/Microvascular Surgery, University of Maryland Greenebaum Cancer Center, Baltimore, Maryland, USA.
authors.forename: S
authors.initials: S
authors.lastname: Caldroney
authors.affiliation: Oral-Head and Neck Surgery/Microvascular Surgery, University of Maryland Greenebaum Cancer Center, Baltimore, Maryland, USA.
authors.forename: N
authors.initials: N
authors.lastname: Ghazali
authors.affiliation: Oral-Head and Neck Surgery/Microvascular Surgery, University of Maryland Greenebaum Cancer Center, Baltimore, Maryland, USA.
authors.forename: D
authors.initials: D
authors.lastname: Dyalram
authors.affiliation: Oral-Head and Neck Surgery/Microvascular Surgery, University of Maryland Greenebaum Cancer Center, Baltimore, Maryland, USA. Electronic address: jlubek@umaryland.edu.
authors.forename: J E
authors.initials: JE
authors.lastname: Lubek
mesh_terms: D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000000981:diagnostic imaging / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D018450:Disease Progression; D005260:Female; D058752:Free Tissue Flaps / Q000098:blood supply; D006801:Humans; D008297:Male; D008875:Middle Aged; D056948:Orthognathic Surgical Procedures / Q000379:methods*; D010027:Osteotomy; D011183:Postoperative Complications; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: MRONJ; mandible; osteonecrosis; vascularized tissue transfer