title: Pharmacogenetics of antidepressant drugs: State of the art and clinical implementation - recommendations from the French National Network of Pharmacogenetics.
abstract: Tailoring antidepressant drug therapy to each individual patient is a complex process because these drugs have adverse effects leading to discontinuation. Pharmacogenetics may provide useful information in routine practice for optimizing antidepressant treatment by helping limit toxic effects while maintaining efficacy. This review presents the usefulness of pharmacogenetic tests for P450 cytochromes CYP2C19 and CYP2D6 in psychiatric patients taking antidepressants. Depending on the level of evidence, the French National Network of Pharmacogenetics (RNPGx) has issued recommendations stating that pharmacogenetic tests for CYP2D6 and CYP2C19 genes are potentially useful in psychiatric patients treated with antidepressant drugs.
authors.affiliation: Service de pharmacocinétique et toxicologie, laboratoire de biologie médicale, CHU Timone, Assistance publique-Hôpitaux de Marseille, 13000 Marseille, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Quaranta
authors.affiliation: Service de pharmacologie UF0598, CNRS, INT, institut neurosciences Timone, CHU Timone, Assistance publique-Hôpitaux de Marseille, Aix-Marseille université, 13000 Marseille, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Dupouey
authors.affiliation: Inserm UMR-S1178, Team "Depressions and Antidepressants", service de psychiatrie, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, université Paris Sud, 94270 Le Kremlin-Bicêtre, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Colle
authors.affiliation: Service de génétique moléculaire et pharmacogénétique, hôpital Bicêtre, AP-HP, 94270 Le Kremlin-Bicêtre, France; Pharmacology department, faculty of medicine Paris-Sud, university Paris Sud, UMR 1184, CEA, DSV/iMETI, division of immuno-virology, IDMIT, INSERM center for immunology of viral infections and autoimmune diseases, Assistance publique-Hôpitaux de Paris, hôpital Bicêtre, Le Kremlin-Bicêtre, France. Electronic address: celine.verstuyft@aphp.fr.
authors.forename: Céline
authors.initials: C
authors.lastname: Verstuyft
mesh_terms: D000928:Antidepressive Agents / Q000493:pharmacokinetics*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D010597:Pharmacogenetics; D000071185:Pharmacogenomic Testing; D011110:Polymorphism, Genetic
chemical_list: D000928:Antidepressive Agents; D001189:Aryl Hydrocarbon Hydroxylases; D019389:Cytochrome P-450 CYP2D6; C105144:cytochrome P-450 CYP2D19 (marmoset)
keywords: Antidepressant drugs; CYP2C19; CYP2D6; Pharmacogenetics; Psychiatry