title: Expiratory flow limitation and operating lung volumes during exercise in older and younger adults.
abstract: We determined the effect of aging on expiratory flow limitation (EFL) and operating lung volumes when matched for lung size. We hypothesized that older adults will exhibit greater EFL and increases in EELV during exercise compared to younger controls. Ten older (5M/5W; >60years old) and nineteen height-matched young adults (10M/9W) were recruited. Young adults were matched for%predicted forced vital capacity (FVC) (Y-matched%Pred FVC; n=10) and absolute FVC (Y-matched FVC; n=10). Tidal flow-volume loops were recorded during the incremental exercise test with maximal flow-volume loops measured pre- and post-exercise. Compared to younger controls, older adults exhibited more EFL at ventilations of 26, 35, 51, and 80L/min. The older group had higher end-inspiratory lung volume compared to Y-matched%Pred FVC group during submaximal ventilations. The older group increased EELV during exercise, while EELV stayed below resting in the Y-matched%Pred FVC group. These data suggest older adults exhibit more EFL and increase EELV earlier during exercise compared to younger adults.
authors.affiliation: Department of Kinesiology, Kansas State University, Manhattan, KS, USA. Electronic address: smith424@ksu.edu.
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Smith
authors.affiliation: Department of Kinesiology, Kansas State University, Manhattan, KS, USA.
authors.forename: Stephanie P
authors.initials: SP
authors.lastname: Kurti
authors.affiliation: Department of Kinesiology, Kansas State University, Manhattan, KS, USA.
authors.forename: Kayla
authors.initials: K
authors.lastname: Meskimen
authors.affiliation: Department of Kinesiology, Kansas State University, Manhattan, KS, USA.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Harms
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D045853:Exhalation / Q000502:physiology*; D005260:Female; D005540:Forced Expiratory Flow Rates / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000502:physiology*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D012132:Respiratory Muscles / Q000502:physiology; D013990:Tidal Volume / Q000502:physiology; D014797:Vital Capacity / Q000502:physiology; D055815:Young Adult
keywords: Aging; Dynamic hyperinflation; Exercise; Expiratory flow limitation; Pulmonary function