title: Compensatory Structural and Functional Adaptation After Nephrectomy in Obese Patients According to Waist Circumference.
abstract: OBJECTIVE
  To investigate whether the postnephrectomy renal adaptation mechanism, focused on functional hyperfiltration as well as structural hypertrophy, was affected by abdominal obesity.
  
  
  METHODS
  We retrospectively evaluated 358 patients who underwent simple or radical nephrectomy and nephroureterectomy between 2009 and 2013. Patients were classified according to waist circumference (WC), with values >102 cm in men and >88 cm in women considered high (obesity). Functional renal volume (FRV) was measured using computed tomography performed preoperatively and 6 months postoperatively to evaluate the degree of remnant kidney hypertrophy. The degree of hyperfiltration was calculated from the difference between the preoperative and postoperative glomerular filtration rate (GFR)/FRV.
  
  
  RESULTS
  The mean preoperative GFR, FRV, and GFR/FRV were 72.1 mL/min/1.73 m2, 282.8 cm3, and 0.25 mL/min/1.73 m2/cm3, respectively. The percent GFR reduction was significantly greater in the high WC group (high, 25.9% vs normal, 16.0%, P = .036), although the degree of hypertrophic volume in the remnant kidney showed no difference. The change in GFR/FRV was statistically lower in the high WC group (high, 25.7% vs normal, 40.2%, P = .009). The factors associated with postoperative increased GFR/FRV were low preoperative GFR, proteinuria, high predictive preserved functional parenchymal volume ratio, absence of hypertension, increased levels of high-density lipoprotein cholesterol, and normal WC (all P < .05).
  
  
  CONCLUSIONS
  Patients with high WC might have a large reduction in postoperative renal function, owing to a lower degree of functional hyperfiltration.
authors.affiliation: Department Urology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Republic of Korea.
authors.forename: Kyung Hwa
authors.initials: KH
authors.lastname: Choi
authors.affiliation: Department Urology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Republic of Korea.
authors.forename: Seung Ryeol
authors.initials: SR
authors.lastname: Lee
authors.affiliation: Department Urology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Republic of Korea.
authors.forename: Young Kwon
authors.initials: YK
authors.lastname: Hong
authors.affiliation: Department Urology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Republic of Korea. Electronic address: dsparkmd@cha.ac.kr.
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Park
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D000368:Aged; D008076:Cholesterol, HDL / Q000378:metabolism; D005260:Female; D005374:Filtration; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D056128:Obesity, Abdominal / Q000150:complications* / Q000601:surgery*; D011184:Postoperative Period; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014513:Ureter / Q000601:surgery; D055105:Waist Circumference
chemical_list: D008076:Cholesterol, HDL