title: Thyroid hormone level is associated with the frequency and severity of acute transverse myelitis.
abstract: Acute transverse myelitis (ATM) is a progressive and autoimmune disease with inflammatory cell infiltrates into the spinal cord, and thyroid hormone (TH) level is associated with the oxidative and antioxidant status. Variations in oxidative stress and antioxidant levels are related to the pathogenesis of autoimmune and inflammatory diseases. Our study aimed to investigate the possible correlation between ATM and TH levels of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), and FT4/FT3. We measured serum concentrations of TSH, FT4, and FT3 in 205 individuals, including 42 ATM patients, 49 multiple sclerosis patients, and 114 healthy controls. Our findings show that ATM patients had lower levels of TSH and FT3 and higher levels of FT4 and FT4/FT3 compared with healthy controls, whether male or female. Moreover, levels of TSH and FT3 in patients with ATM were inversely correlated with disease severity measured by the Expanded Disability Status Scale. Variations in TH level may represent the oxidative status and are surrogate biomarkers of the incidence and severity of ATM.
authors.affiliation: aDepartment of Neurology bDepartment of Gastroenterology cFunctional Department, the First Affiliated Hospital of Wenzhou Medical University dSchool of the First Clinical Medical Sciences eSchool of Medical University, Wenzhou, Zhejiang, People's Republic of China.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Weng
authors.forename: Huiyue
authors.initials: H
authors.lastname: Lin
authors.forename: Xiaoxian
authors.initials: X
authors.lastname: Ye
authors.forename: Dewei
authors.initials: D
authors.lastname: Xie
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Chen
authors.forename: Juzeng
authors.initials: J
authors.lastname: Zheng
authors.forename: Zhongqian
authors.initials: Z
authors.lastname: Su
authors.forename: Hongli
authors.initials: H
authors.lastname: Xie
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009188:Myelitis, Transverse / Q000097:blood*; D012372:ROC Curve; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine