title: Preoperative inflammation markers and IDH mutation status predict glioblastoma patient survival.
abstract: Recent studies suggest that inflammation response biomarkers are prognostic indicators of solid tumor outcomes. Here, we quantify the prognostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in glioblastomas (GBMs), taking into consideration the role of the isocitrate dehydrogenase (IDH) mutation status. We examined 141 primary glioblastomas (pGBMs) and 25 secondary glioblastomas (sGBMs). NLRs, PLRs, and LMRs were calculated before surgery. IDH mutations were detected immunohistochemically after tumor resection, and patients' clinical outcomes were analyzed after classification into GBM, pGBM, and IDH-wild type glioblastoma (IDH-wt GBM) groups. To make comparisons, we set cutoffs for NLR, PLR and LMR of 4.0, 175.0, and 3.7, respectively. In a multivariate analysis, both NLR (HR=1.712, 95% CI 1.026-2.858, p=0.040) and PLR (HR=2.051, 95% CI 1.288-3.267, p=0.002) had independent prognostic value. While a low NLR was associated with a better prognosis only in the IDH-wt GBM group, PLR was predictive of patient survival in the GBM, pGBM, and IDH-wt GBM groups. By contrast, LMR exhibited no prognostic value for any of the 3 types of GBM.
authors.affiliation: Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, China.
authors.forename: Hong-Wang
authors.initials: HW
authors.lastname: Song
authors.affiliation: Department of Neurosurgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
authors.forename: Hong-Qing
authors.initials: HQ
authors.lastname: Cai
authors.affiliation: Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, China.
authors.forename: Ling-Wei
authors.initials: LW
authors.lastname: Kong
authors.affiliation: Department of Pathology, Sanbo Brain Hospital, Capital Medical University, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Yao
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|Beijing Neurosurgical Institute, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, China.
authors.forename: Shou-Wei
authors.initials: SW
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, China.
authors.forename: Chang-Xiang
authors.initials: CX
authors.lastname: Yan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D005260:Female; D005909:Glioblastoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007521:Isocitrate Dehydrogenase / Q000378:metabolism*; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology; D009154:Mutation; D009504:Neutrophils / Q000473:pathology; D057234:Preoperative Period; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D007521:Isocitrate Dehydrogenase
keywords: IDH-1 R132H mutation; glioblastomas; lymphocyte to monocyte ratio; neutrophil to lymphocyte ratio; platelet to lymphocyte ratio