title: Concurrent apatinib and local radiation therapy for advanced gastric cancer: A case report and review of the literature.
abstract: BACKGROUND
  Apatinib is a novel anti-angiogenic agent targeting vascular endothelial growth factor receptor-2, which is effective in patients with chemotherapy-refractory gastric cancer. There are no reports of concurrent apatinib with local radiation therapy in elderly patients with advanced gastric cancer. PATIENT CONCERNS AND DIAGNOSES:: we present the first published report of a 70-year-old male patient with advanced gastric cancer who received concurrent apatinib and local radiation therapy after failure of oxaliplatin and S-1 chemotherapy.
  
  
  RESULTS
  The patient received concurrent apatinib and local radiation therapy and was followed up 7 months after therapy without disease progress, 14 months later indicated extensive metastasis and this patient died of pulmonary infection.
  
  
  CONCLUSIONS
  Elderly patients with advanced gastric cancer may benefit from concurrent apatinib with local radiation therapy when chemotherapy is not tolerated or successful. Further studies are needed to investigate the clinical outcomes and toxicities associated with concurrent apatinib and radiation therapy in gastric cancer.
authors.affiliation: Department of Radiation Oncology, Hebei General Hospital, Shijiazhuang, China Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas School of Public Health at Houston, Houston, TX Department of Gastrointestinal Surgery Department of Pathology, Hebei General Hospital, Shijiazhuang, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Weiye
authors.initials: W
authors.lastname: Deng
authors.forename: Xiaoci
authors.initials: X
authors.lastname: Cao
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Shi
authors.forename: Huanfen
authors.initials: H
authors.lastname: Zhao
authors.forename: Zheping
authors.initials: Z
authors.lastname: Duan
authors.forename: Bonan
authors.initials: B
authors.lastname: Lv
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000532:radiotherapy*; D000368:Aged; D059248:Chemoradiotherapy; D006801:Humans; D008297:Male; D011725:Pyridines / Q000627:therapeutic use*; D050397:Radiotherapy, Intensity-Modulated; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*
chemical_list: D011725:Pyridines; C553458:apatinib