title: Formation and characterization of Langmuir and Langmuir-Blodgett films of Newkome-type dendrons in presence and absence of a therapeutic compound, for the development of surface mediated drug delivery systems.
abstract: Organic macromolecules with dendrimeric architectures are polymeric materials potentially useful as nanocarriers for therapeutic drugs. In this work, we evaluate a series of Newkome-type dendrons in Langmuir and Langmuir-Blodgett films as platforms capable of interacting with a potential antitumoral agent. The nanocomposite is proposed as model for the development of surface mediated drug delivery systems. We were successful in the formation and characterization of pure (dendrons) and composite (drug-dendron) stable and reproducible monolayers, and their transfer to solid substrates. A detailed study of topographic characteristics of the generated surfaces by atomic force microscopy was conducted. Furthermore, we probed dendron monolayer films as anchorage surfaces for mammalian cells. Normal cell attachment and proliferation on the surfaces were observed. No evident cytotoxic effects were detected, demonstrating the adequate biocompatibility of the surfaces.
authors.affiliation: Departamento de Física, Departamento de Química, Universidad Nacional de Río Cuarto, CONICET, Agencia Postal 3, X5804BYA Río Cuarto, Argentina.
authors.forename: Nahir
authors.initials: N
authors.lastname: Dib
authors.affiliation: Departamento de Física, Departamento de Química, Universidad Nacional de Río Cuarto, CONICET, Agencia Postal 3, X5804BYA Río Cuarto, Argentina.
authors.forename: Ana Lucia
authors.initials: AL
authors.lastname: Reviglio
authors.affiliation: Departamento de Física, Departamento de Química, Universidad Nacional de Río Cuarto, CONICET, Agencia Postal 3, X5804BYA Río Cuarto, Argentina.
authors.forename: Luciana
authors.initials: L
authors.lastname: Fernández
authors.affiliation: Departamento de Física, Departamento de Química, Universidad Nacional de Río Cuarto, CONICET, Agencia Postal 3, X5804BYA Río Cuarto, Argentina.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Morales
authors.affiliation: Departamento de Física, Departamento de Química, Universidad Nacional de Río Cuarto, CONICET, Agencia Postal 3, X5804BYA Río Cuarto, Argentina.
authors.forename: Marisa
authors.initials: M
authors.lastname: Santo
authors.affiliation: Departamento de Física, Departamento de Química, Universidad Nacional de Río Cuarto, CONICET, Agencia Postal 3, X5804BYA Río Cuarto, Argentina. Electronic address: lotero@exa.unrc.edu.ar.
authors.forename: Luis
authors.initials: L
authors.lastname: Otero
authors.affiliation: Departamento de Biología Molecular, Universidad Nacional de Río Cuarto, Agencia Postal 3, X5804BYA Río Cuarto, Argentina.
authors.forename: Fabrisio
authors.initials: F
authors.lastname: Alustiza
authors.affiliation: Departamento de Biología Molecular, Universidad Nacional de Río Cuarto, Agencia Postal 3, X5804BYA Río Cuarto, Argentina.
authors.forename: Ana Cecilia
authors.initials: AC
authors.lastname: Liaudat
authors.affiliation: Departamento de Biología Molecular, Universidad Nacional de Río Cuarto, Agencia Postal 3, X5804BYA Río Cuarto, Argentina.
authors.forename: Pablo
authors.initials: P
authors.lastname: Bosch
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Calderón
authors.affiliation: IPQA-CONICET, Departamento de Química Orgánica, Facultad Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Edificio de Cs. II, Ciudad Universitaria, Córdoba 5000, Argentina.
authors.forename: Marisa
authors.initials: M
authors.lastname: Martinelli
authors.affiliation: IPQA-CONICET, Departamento de Química Orgánica, Facultad Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Edificio de Cs. II, Ciudad Universitaria, Córdoba 5000, Argentina.
authors.forename: Miriam
authors.initials: M
authors.lastname: Strumia
mesh_terms: D015766:Albendazole / Q000737:chemistry / Q000633:toxicity; D000814:Aniline Compounds / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity; D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion; D049109:Cell Proliferation / Q000187:drug effects; D050091:Dendrimers / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D051379:Mice; D018625:Microscopy, Atomic Force; D041681:NIH 3T3 Cells; D049329:Nanostructures / Q000737:chemistry*; D009578:Nitrobenzenes / Q000737:chemistry; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D000814:Aniline Compounds; D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D050091:Dendrimers; D004337:Drug Carriers; D009578:Nitrobenzenes; D015766:Albendazole
keywords: Cell culture; Dendrons; Drug-carriers composites; Langmuir monolayers