title: Lanolin-based organogel of salicylic acid: evidences of better dermatokinetic profile in imiquimod-induced keratolytic therapy in BALB/c mice model.
abstract: The primary aim of the present study was to develop lanolin-based organogel with enhanced delivery potential and reduced skin irritation for the treatment of hyperkeratotic lesions and scaling. The drug was encapsulated in the lipidic bilayers of organogel. The values of particle size, polydispersity index (PDI), and zeta potential of the developed carrier system was found to be 257.5 nm, 0.272, and -24.9 mV, respectively. The system was pseudoplastic in nature with the yield value of 2.3078 Pa. The skin permeation studies exhibited superiority of the prepared lanolin-based organogel formulation over the conventional gel formulation (CGF). Further, the dermatokinetic studies also confirmed better permeation and enhanced skin bioavailability of SA to epidermis as well as dermis vis-à-vis the CGF. In conclusion, the developed organogel system not only improved the delivery profile of SA but also reduced the skin irritant potential. The current findings can provide a suitable alternative for the development of an effective topical formulation of SA for the treatment of hyperkeratotic lesions.
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, 160 014, India.
authors.forename: Gajanand
authors.initials: G
authors.lastname: Sharma
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, 160 014, India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Devi
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, 160 014, India.
authors.forename: Kanika
authors.initials: K
authors.lastname: Thakur
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, 160 014, India.
authors.forename: Ashay
authors.initials: A
authors.lastname: Jain
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, 160 014, India. katare@pu.ac.in.
authors.forename: O P
authors.initials: OP
authors.lastname: Katare
mesh_terms: D000287:Administration, Topical; D000634:Aminoquinolines; D000818:Animals; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D005079:Excipients / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D005782:Gels; D000077271:Imiquimod; D007641:Keratolytic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D007642:Keratosis / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D007809:Lanolin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D008807:Mice, Inbred BALB C; D020156:Salicylic Acid / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D012869:Skin Absorption
chemical_list: D000634:Aminoquinolines; D004337:Drug Carriers; D005079:Excipients; D005782:Gels; D007641:Keratolytic Agents; D007809:Lanolin; D020156:Salicylic Acid; D000077271:Imiquimod
keywords: Dermatokinetic; Hyperkeratosis; Imiquimod; Lanolin; Lipid-based delivery; NSAIDs; Organogel