title: Protective effects on liver, kidney and pancreas of enzymatic- and acidic-hydrolysis of polysaccharides by spent mushroom compost (Hypsizigus marmoreus).
abstract: The present work investigated the protective effects on liver, kidneys and pancreas of spent mushroom compost polysaccharide (SCP) and its hydrolysates (enzymatic- (ESCP) and acid-hydrolyzed SCP (ASCP)) from Hypsizigus marmoreus, in streptozotocin (STZ)-induced diabetic mice. The results showed that enzymatic (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)) and non-enzymatic activities (total antioxidant capacity (T-AOC)) were significantly increased, the lipid peroxide contents (lipid peroxide (LPO) and malonaldehyde (MDA)) were remarkably reduced, and the clinical parameters were observably mitigated in diabetic mice treated with these three polysaccharides. Furthermore, histological observations also indicated recovery. These conclusions demonstrated that both SCP and its hydrolysates ESCP and ASCP possessed potent antioxidant activities and can be used as a potentially functional food for the prevention of diabetes and its complications induced by STZ.
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.|Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing Engineering Research Center for Edible Mushroom, Key Laboratory of Urban Agriculture (North), Ministry of Agriculture, Beijing, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Xinling
authors.initials: X
authors.lastname: Song
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Gao
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Shangshang
authors.initials: S
authors.lastname: Li
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Jing
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Ren
authors.affiliation: Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing Engineering Research Center for Edible Mushroom, Key Laboratory of Urban Agriculture (North), Ministry of Agriculture, Beijing, PR China.
authors.forename: Shouxian
authors.initials: S
authors.lastname: Wang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Le
authors.initials: L
authors.lastname: Jia
mesh_terms: D000363:Agaricales / Q000254:growth & development / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism*; D000076282:Composting; D048909:Diabetes Complications / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D006868:Hydrolysis; D007668:Kidney / Q000502:physiology; D008099:Liver / Q000502:physiology; D051379:Mice; D010179:Pancreas / Q000502:physiology; D011134:Polysaccharides / Q000008:administration & dosage / Q000378:metabolism*; D012988:Soil Microbiology; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D011134:Polysaccharides