title: Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification.
abstract: Nature provides a valuable resource of medicinally relevant compounds, with many antimicrobial and antitumor agents entering clinical trials being derived from natural products. The generation of analogues of these bioactive natural products is important in order to gain a greater understanding of structure activity relationships; probing the mechanism of action, as well as to optimise the natural product's bioactivity and bioavailability. This chapter critically examines different approaches to generating natural products and their analogues, exploring the way in which synthetic and biosynthetic approaches may be blended together to enable expeditious access to new designer natural products.
authors.affiliation: School of Chemistry, University of St Andrews, St Andrews, Scotland, UK.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Zarins-Tutt
authors.affiliation: School of Chemistry, University of St Andrews, St Andrews, Scotland, UK.
authors.forename: Emily R
authors.initials: ER
authors.lastname: Abraham
authors.affiliation: School of Chemistry, University of St Andrews, St Andrews, Scotland, UK.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Bailey
authors.affiliation: School of Chemistry, University of St Andrews, St Andrews, Scotland, UK. rjmg@st-andrews.ac.uk.
authors.forename: Rebecca J M
authors.initials: RJ
authors.lastname: Goss
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000639:trends*; D002626:Chemistry, Pharmaceutical / Q000639:trends*; D020650:Combinatorial Chemistry Techniques / Q000639:trends; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000639:trends; D057166:High-Throughput Screening Assays / Q000639:trends; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D013678:Technology, Pharmaceutical / Q000639:trends
chemical_list: D001688:Biological Products; D004364:Pharmaceutical Preparations