title: The role of infectious hematopoietic necrosis virus (IHNV) proteins in the modulation of NF-κB pathway during IHNV infection.
abstract: Viral infections frequently lead to the activation of host innate immune signaling pathways involved in the defense against invading pathogens. To ensure their survival, viruses have evolved sophisticated mechanisms to overcome the host immune responses. The present study demonstrated for the first time that infectious hematopoietic necrosis virus (IHNV) activated NF-κB pathway in fish cells. We further identified that the IHNV L protein could activate the NF-κB signaling pathway and that IHNV NV functioned as an inhibitor of NF-κB activation. Further results demonstrated that the NV protein blocked the degradation of the inhibitor of NF-κB (IκBα) and suppressed the SeV-induced NF-κB nuclear translocation. In conclusion, our study explored the functions of different IHNV proteins on NF-κB activation, and revealed a potential mechanism by which IHNV evades innate immune responses.
authors.affiliation: Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: College of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang, China.
authors.forename: Mengting
authors.initials: M
authors.lastname: Guo
authors.affiliation: College of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Hua
authors.affiliation: College of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang, China.
authors.forename: Kexin
authors.initials: K
authors.lastname: Duan
authors.affiliation: College of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang, China.
authors.forename: Gaihong
authors.initials: G
authors.lastname: Lian
authors.affiliation: College of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang, China.
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.
authors.forename: Yigang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: College of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang, China. Electronic address: liumin-707@163.com.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China. Electronic address: yijingli@163.com.
authors.forename: Yijing
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D002460:Cell Line; D005393:Fish Diseases / Q000235:genetics* / Q000276:immunology / Q000821:virology; D029941:Fish Proteins / Q000235:genetics* / Q000378:metabolism; D007113:Immunity, Innate; D029142:Infectious hematopoietic necrosis virus / Q000502:physiology*; D016328:NF-kappa B / Q000235:genetics* / Q000378:metabolism; D018353:Rhabdoviridae Infections / Q000235:genetics / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D012474:Salmon; D015398:Signal Transduction; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D029941:Fish Proteins; D016328:NF-kappa B; D014764:Viral Proteins
keywords: Immune-evasion; Infectious hematopoietic necrosis virus; NF-κB; NV protein; Pathogenesis