title: Early-life exposures predicting onset and resolution of childhood overweight or obesity.
abstract: To determine which of multiple early-life exposures predict onset or resolution of overweight/obesity during a 9-year period.
  
  
  
  Design: longitudinal cohort from three harmonised community-based cohorts enriched for overweight and obesity.Early-life exposures: child-gestational age; delivery; birth weight; breast feeding; solids introduction; baseline body mass index (BMI); waist circumference; diet; activity; global, physical and psychosocial health. Mother-baseline BMI; education; age; neighbourhood disadvantage; concern for child's weight.Outcome: change in BMI category.Analyses: adjusted logistic regression.
  
  
  
  On average, the 363 children (57% retention) were 6 and 15 years old at baseline and follow-up. Children were classified as 'never' overweight/obese (38%), 'resolving' overweight/obese (15%), 'becoming' overweight/obese (8%) or 'always' overweight/obese (39%). Compared with 'never overweight/obese' children, odds of 'becoming overweight/obese' were greater with higher child (OR 2.33, 95% CI 1.02 to 5.29) and maternal BMI (OR 1.18, CI 1.07 to 1.31), and lower with higher maternal education (OR 0.09, CI 0.02 to 0.34). Compared with 'always overweight/obese' children, odds of 'resolving overweight/obese' were lower with higher maternal BMI (OR 0.87, CI 0.78 to 0.97), and higher with better child physical health (OR 1.06, CI 1.02 to 1.10) and higher maternal age (OR 1.11, CI 1.01 to 1.22) and education (OR 4.07, CI 1.02 to 16.19).
  
  
  
  Readily available baseline information (child/maternal BMI, maternal age, education and child health) were the strongest predictors of both onset and resolution of overweight/obesity between the primary school and adolescent years. Perinatal, breastfeeding and lifestyle exposures were not strongly predictive. Results could stimulate development of algorithms identifying children most in need of targeted prevention or treatment.
authors.affiliation: Murdoch Childrens Research Institute, Parkville, Victoria, Australia.|Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Jessica A
authors.identifier: 0000-0002-3150-4047
authors.initials: JA
authors.lastname: Kerr
authors.affiliation: Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Catherine
authors.initials: C
authors.lastname: Long
authors.affiliation: Murdoch Childrens Research Institute, Parkville, Victoria, Australia.|Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Susan A
authors.initials: SA
authors.lastname: Clifford
authors.affiliation: Murdoch Childrens Research Institute, Parkville, Victoria, Australia.
authors.forename: Joshua
authors.initials: J
authors.lastname: Muller
authors.affiliation: Murdoch Childrens Research Institute, Parkville, Victoria, Australia.|Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Alanna N
authors.initials: AN
authors.lastname: Gillespie
authors.affiliation: Murdoch Childrens Research Institute, Parkville, Victoria, Australia.|Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Susan
authors.initials: S
authors.lastname: Donath
authors.affiliation: Murdoch Childrens Research Institute, Parkville, Victoria, Australia.|Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.|Department of Paediatrics & Liggins Institute, University of Auckland, Grafton, Auckland, New Zealand.
authors.forename: Melissa
authors.identifier: 0000-0002-5958-8596
authors.initials: M
authors.lastname: Wake
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D002648:Child; D015331:Cohort Studies; D005247:Feeding Behavior; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008019:Life Style; D008137:Longitudinal Studies; D008297:Male; D050177:Overweight / Q000453:epidemiology / Q000209:etiology*; D063766:Pediatric Obesity / Q000453:epidemiology / Q000209:etiology*; D011446:Prospective Studies; D012307:Risk Factors
keywords: Adolescent Health; Comm Child Health; Obesity