title: Modulators of the Balance between M1 and M2 Macrophages during Pregnancy.
abstract: Macrophages are a subset of mononuclear phagocytes of the innate immune system with high plasticity and heterogeneity. At the maternal-fetal interface, macrophages are present in all stages of pregnancy and involved in a variety of activities, including regulation of immune cell activities, decidualization, placental cell invasion, angiogenesis, parturition, and postpartum uterine involution. The activation state and function of uterine-placental macrophages are largely dependent on the local tissue microenvironment. However, disruption of the uterine microenvironment can have profound effects on macrophage activity and subsequently impact pregnancy outcome. Thus, appropriately and timely regulated macrophage polarization has been considered a key determinant of successful pregnancy. Targeting macrophage polarization might be an efficient strategy for maintaining maternal-fetal immune homeostasis and a normal pregnancy. Here, we will review the latest findings regarding the modulators regulating macrophage polarization in healthy pregnancies and pregnancy complications, which might provide a basis for macrophage-centered therapeutic strategies.
authors.affiliation: Family Planning Research Institute, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , P.R. China.
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Hubei Province , Wuhan , P.R. China.
authors.forename: Ming
authors.initials: M
authors.lastname: He
authors.affiliation: Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Hubei Province , Wuhan , P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Family Planning Research Institute, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , P.R. China.
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Liao
keywords: GM-CSF; HLA-G; Tim-3; macrophage; maternal-fetal interface; notch signal; polarization; pregnancy