title: Multifunctional Theranostic Agent of Cu2(OH)PO4Quantum Dots for Photoacoustic Image-Guided Photothermal/Photodynamic Combination Cancer Therapy.
abstract: Image-guided phototherapy is considered to be a prospective technique for cancer treatment because it can provide both oncotherapy and bioimaging, thus achieving an optimized therapeutic efficacy and higher treatment accuracy. Compared to complicated systems with multiple components, using a single material for this multifunctional purpose is preferable. In this work, we strategically fabricated poly(acrylic acid)- (PAA-) coated Cu2(OH)PO4quantum dots [denoted as Cu2(OH)PO4@PAA QDs], which exhibit a strong near-infrared photoabsorption ability. As a result, an excellent photothermal conversion ability and the photoactivated formation of reactive oxygen species could be realized upon NIR irradiation, concurrently meeting the basic requirements for photothermal and photodynamic therapies. Moreover, phototherapeutic investigations on both cervical cancer cells in vitro and solid tumors of an in vivo mice model illustrated the effective antitumor effects of Cu2(OH)PO4@PAA upon 1064-nm laser irradiation, with no detectable lesions in major organs during treatment. Meanwhile, Cu2(OH)PO4@PAA is also an exogenous contrast for photoacoustic tomography (PAT) imaging to depict tumors under NIR irradiation. In brief, the Cu2(OH)PO4@PAA QDs prepared in this work are expected to serve as a multifunctional theranostic platform.
authors.affiliation: School of Life and Technology and ‡Key Laboratory of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology , Harbin 150080, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.affiliation: School of Life and Technology and ‡Key Laboratory of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology , Harbin 150080, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Qiu
authors.affiliation: School of Life and Technology and ‡Key Laboratory of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology , Harbin 150080, China.
authors.forename: Chongshen
authors.identifier: http://orcid.org/0000-0002-8000-7434
authors.initials: C
authors.lastname: Guo
authors.affiliation: School of Life and Technology and ‡Key Laboratory of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology , Harbin 150080, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Ding
authors.affiliation: School of Life and Technology and ‡Key Laboratory of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology , Harbin 150080, China.
authors.forename: Tianchan
authors.initials: T
authors.lastname: Li
authors.affiliation: School of Life and Technology and ‡Key Laboratory of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology , Harbin 150080, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: School of Life and Technology and ‡Key Laboratory of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology , Harbin 150080, China.
authors.forename: Jianzhe
authors.initials: J
authors.lastname: Sun
authors.affiliation: School of Life and Technology and ‡Key Laboratory of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology , Harbin 150080, China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Zheng
authors.affiliation: School of Life and Technology and ‡Key Laboratory of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology , Harbin 150080, China.
authors.forename: Shaoqin
authors.initials: S
authors.lastname: Liu
mesh_terms: D000818:Animals; D003300:Copper; D006878:Hydroxides; D051379:Mice; D010789:Phototherapy; D011446:Prospective Studies; D045663:Quantum Dots; D000068936:Theranostic Nanomedicine
chemical_list: D006878:Hydroxides; C508959:copper hydroxide; D003300:Copper
keywords: Cu2(OH)PO4; photoacoustic imaging; photodynamic therapy; photothermal therapy; theranostics