title: NFATC1 genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients.
abstract: OBJECTIVE
  To investigate the effects of SNPs in the cyclophilin A/calcineurin/nuclear factor of activated T-cells (NFATs) pathway genes (PPIA, PPP3CB, PPP3R1, NFATC1 and NFATC2) on cyclosporine (CsA) efficacy in renal transplant recipients.
  
  
  METHODS
  Seventy-six tag SNPs were detected in 155 CsA-treated renal recipients with at least a 5-year follow-up. The associations of SNPs with acute rejection, nephrotoxicity, pneumonia and estimated glomerular filtration rate post transplant were explored.
  
  
  RESULTS
  NFATC1 rs3894049 GC was a risk factor for acute rejection compared with CC carriers (p = 0.0005). NFATC1 rs2280055 TT carriers had a more stable estimated glomerular filtration rate level than CC (p = 0.0004).
  
  
  CONCLUSIONS
  Detecting NFATC1 polymorphisms could help predict CsA efficacy in renal transplant patients.
authors.affiliation: Department of Pharmacy, Huashan hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, China.
authors.forename: Qinxia
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Pharmacy, Huashan hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Pharmacy, Huashan hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jiao
authors.affiliation: Department of Nephrology, Huashan hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Key Lab of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, 779 Lao Hu Min Road, Shanghai, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, Huashan hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, China.
authors.forename: Mingkang
authors.initials: M
authors.lastname: Zhong
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics* / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects / Q000639:trends*; D008297:Male; D008875:Middle Aged; D050778:NFATC Transcription Factors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012189:Retrospective Studies; D016037:Single-Blind Method; D066027:Transplant Recipients; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D050778:NFATC Transcription Factors; C494003:NFATC1 protein, human; D016572:Cyclosporine
keywords: NFATC1; NFATC2; PPIA; PPP3CB; PPP3R1; SNPs; cyclosporine; pharmacodynamics; renal transplantation