title: The Usage of ACCLUSTER for Peptide Binding Site Prediction.
abstract: Peptides mediate up to 40 % of protein-protein interactions in a variety of cellular processes and are also attractive drug candidates. Thus, predicting peptide binding sites on the given protein structure is of great importance for mechanistic investigation of protein-peptide interactions and peptide therapeutics development. In this chapter, we describe the usage of our web server, referred to as ACCLUSTER, for peptide binding site prediction for a given protein structure. ACCLUSTER is freely available for users without registration at http://zougrouptoolkit.missouri.edu/accluster .
authors.affiliation: Department of Physics and Astronomy, Department of Biochemistry, Dalton Cardiovascular Research Center, Informatics Institute, University of Missouri, 134 Research Park Drive, 117A Dalton Bldg, Columbia, MO, 65211, USA.
authors.forename: Chengfei
authors.initials: C
authors.lastname: Yan
authors.affiliation: Department of Physics and Astronomy, Department of Biochemistry, Dalton Cardiovascular Research Center, Informatics Institute, University of Missouri, 134 Research Park Drive, 117A Dalton Bldg, Columbia, MO, 65211, USA.
authors.forename: Xianjin
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Physics and Astronomy, Department of Biochemistry, Dalton Cardiovascular Research Center, Informatics Institute, University of Missouri, 134 Research Park Drive, 117A Dalton Bldg, Columbia, MO, 65211, USA. zoux@missouri.edu.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Zou
mesh_terms: D000818:Animals; D001665:Binding Sites; D030562:Databases, Protein; D056890:Eukaryota / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D062105:Molecular Docking Simulation; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D012984:Software; D064878:Web Browser
chemical_list: D010446:Peptide Fragments; D011506:Proteins
keywords: Binding site prediction; Molecular docking; Protein–peptide interaction