title: Synthesis of Functionalized Benzo[b]furans via Oxidative Cyclization of o-Cinnamyl Phenols.
abstract: Disclosed herein is an efficient synthetic route for the synthesis of functionalized 2-benzyl benzo[b]furans via a regioselective 5-exo-trig intramolecular oxidative cyclization of ortho-cinnamyl phenols using [PdCl2(CH3CN)2] as catalyst and benzoquinone as an oxidant. Further, a sequential ortho-cinnamylation of phenols using cinnamyl alcohols catalyzed by Re2O7, followed by an oxidative cyclization using the above Pd catalyst, is performed. The reaction showed broad substrate scope with good to excellent yields.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhauri, Bhopal-462066, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rehan
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhauri, Bhopal-462066, India.
authors.forename: Rajender
authors.initials: R
authors.lastname: Nallagonda
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhauri, Bhopal-462066, India.
authors.forename: Braja Gopal
authors.initials: BG
authors.lastname: Das
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhauri, Bhopal-462066, India.
authors.forename: Tannu
authors.initials: T
authors.lastname: Meena
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhauri, Bhopal-462066, India.
authors.forename: Prasanta
authors.identifier: 0000-0001-5120-2700
authors.initials: P
authors.lastname: Ghorai