title: Toward Hydrogen Sulfide Based Therapeutics: Critical Drug Delivery and Developability Issues.
abstract: Hydrogen sulfide (H2S), together with nitric oxide (NO) and carbon monoxide (CO), belongs to the gasotransmitter family and plays important roles in mammals as a signaling molecule. Many studies have also shown the various therapeutic effects of H2S, which include protection against myocardial ischemia injury, cytoprotection against oxidative stress, mediation of neurotransmission, inhibition of insulin signaling, regulation of inflammation, inhibition of the hypoxia-inducible pathway, and dilation of blood vessels. One major challenge in the development of H2S-based therapeutics is its delivery. In this manuscript, we assess the various drug delivery strategies in the context of being used research tools and eventual developability as therapeutic agents.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia.
authors.forename: Yueqin
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia.
authors.forename: Bingchen
authors.initials: B
authors.lastname: Yu
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia.
authors.forename: Ladie Kimberly
authors.initials: LK
authors.lastname: De La Cruz
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia.
authors.forename: Manjusha
authors.initials: M
authors.lastname: Roy Choudhury
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia.
authors.forename: Abiodun
authors.initials: A
authors.lastname: Anifowose
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia.
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D006862:Hydrogen Sulfide / Q000008:administration & dosage* / Q000378:metabolism* / Q000493:pharmacokinetics; D011355:Prodrugs / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D011355:Prodrugs; D006862:Hydrogen Sulfide
keywords: H2S delivery; H2S prodrugs developability; gasotransmitter; hydrogen sulfide donors; hydrogen sulfide(H2S)