title: Mental State Understanding in Children with Agenesis of the Corpus Callosum.
abstract: Impaired social functioning is a well-known outcome of individuals with agenesis of the corpus callosum. Social deficits in nonliteral language comprehension, humor, social reasoning, and recognition of facial expression have all been documented in adults with agenesis of the corpus callosum. In the present study, we examined the emotional and mentalizing deficits that contributing to the social-cognitive development in children with isolated corpus callosum agenesia, including emotion recognition, theory of mind, executive function, working memory, and behavioral impairments as assessed by the parents. The study involved children between the age of 6 and 8 years along with typically developing children who were matched by IQ, age, gender, education, and caregiver's education. The findings indicated that children with agenesis of the corpus callosum exhibited mild impairments in all social factors (recognizing emotions, understanding theory of mind), and showed more behavioral problems than control children. Taken together, these findings suggest that reduced callosal connectivity may contribute to the development of higher-order social-cognitive deficits, involving limits of complex and rapidly occurring social information to be processed. The studies of AgCC shed lights of the role of structural connectivity across the hemispheres in neurodevelopmental disorders.
authors.affiliation: Department of General and Evolutionary Psychology, Institute of Psychology, University of Pécs Pécs, Hungary.
authors.forename: Beatrix
authors.initials: B
authors.lastname: Lábadi
authors.affiliation: Obstetric and Gynecology Clinic No. 1, Semmelweis University Budapest, Hungary.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Beke
keywords: agenesis of the corpus callosum; behavioral problems; emotion recognition; executive function; mentalizing ability