title: A Diastereoselective Multicomponent Reaction for Construction of Alkynylamide-Substituted α,β-Diamino Acid Derivatives To Hunt Hits.
abstract: A highly diasetereoselective Mannich-type multicomponent reaction was developed to rapidly construct alkynylamide-substituted α,β-diamino acid derivatives from simple starting materials under mild conditions in moderate to good yields for hit hunting. Most of the resulting products 4 exhibited good anticancer activity in HCT116, BEL7402, and SMMC7721 cells.
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Chemical Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, China.
authors.forename: Ruirui
authors.initials: R
authors.lastname: Lei
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Chemical Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Chemical Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, China.
authors.forename: Suzhen
authors.initials: S
authors.lastname: Dong
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Chemical Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, China.
authors.forename: Kaili
authors.initials: K
authors.lastname: Jia
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Chemical Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, China.
authors.forename: Shunying
authors.initials: S
authors.lastname: Liu
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Chemical Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, China.
authors.forename: Wenhao
authors.identifier: 0000-0002-1461-3671
authors.initials: W
authors.lastname: Hu