title: Maternal Prepregnancy BMI and Glucose Level at 24-28 Gestational Weeks on Offspring's Overweight Status within 3 Years of Age.
abstract: Objective. To examine the relative impact of maternal prepregnancy body mass index (BMI) and glucose level at 24-28 gestational weeks on offspring's overweight status from birth to 3 years of age in China.Methods. Health care records of 21,354 mother-child pairs were collected. The single and joint associations of maternal prepregnancy BMI and glucose level at 24-28 gestational weeks with 0-3-year-old offspring's overweight status were assessed.Results. The odds ratios (95% confidence intervals) of offspring's macrosomia at birth and overweight/obesity at the 12th month, 24th month, and 36th month were 1.12 (1.11-1.13), 1.05 (1.04-1.06), 1.07 (1.06-1.08), and 1.11 (1.10-1.12) for each 1-unit increase (km/m2) in maternal prepregnancy BMI and 1.13 (1.10-1.17), 1.01 (0.99-1.03), 0.99 (0.96-1.01), and 1.00 (0.97-1.02) for each 1-unit increase (mmol/L) in maternal glucose level at 24-28 gestational weeks, respectively. The positive association of maternal glucose level with macrosomia at birth was similar between prepregnancy normal weight (BMI < 24 kg/m2) and overweight (BMI ≥ 24 kg/m2); however, the positive association of high maternal glucose level with childhood overweight was only seen among prepregnancy normal weight mothers but not among overweight mothers.Conclusions. The impact of maternal gestational hyperglycemia on offspring's overweight before 3 years of age can be modified by prepregnancy BMI.
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China; Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
authors.forename: Weiqin
authors.initials: W
authors.lastname: Li
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Leishen
authors.initials: L
authors.lastname: Wang
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Huikun
authors.initials: H
authors.lastname: Liu
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
authors.forename: Gang
authors.identifier: 0000-0002-6172-8017
authors.initials: G
authors.lastname: Hu
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin 300070, China.
authors.forename: Junhong
authors.identifier: 0000-0002-6742-0830
authors.initials: J
authors.lastname: Leng
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002675:Child, Preschool; D016001:Confidence Intervals; D005260:Female; D005320:Fetal Macrosomia / Q000097:blood / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D007223:Infant; D016017:Odds Ratio; D050177:Overweight / Q000453:epidemiology*; D011247:Pregnancy
chemical_list: D001786:Blood Glucose