title: Ganglioglioma Arising From Desmoplastic Medulloblastoma: A Case Report and Review of Literature.
abstract: We describe a case of medulloblastoma maturating into ganglioglioma during therapy. A 10-month-old boy was diagnosed with a desmoplastic medulloblastoma and was treated with gross total resection followed by induction chemotherapy. A recurrence in the tumor bed during therapy was managed with focal radiation therapy and consolidation chemotherapy. After further progression, the recurrent tumor was resected completely. The histopathology revealed a benign ganglioglioma with no residual medulloblastoma. This case raises the possibility that a malignant medulloblastoma can differentiate into a benign tumor and suggests that differentiation therapy may have value in the treatment of medulloblastoma.
authors.affiliation: Princess Margaret Hospital for Children, Perth, Western Australia, Australia; santosh.valvi@health.wa.gov.au.
authors.forename: Santosh
authors.initials: S
authors.lastname: Valvi
authors.affiliation: Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia; and.|School of Women's and Children's Health, University of New South Wales, Australia.
authors.forename: David S
authors.initials: DS
authors.lastname: Ziegler
mesh_terms: D002528:Cerebellar Neoplasms / Q000473:pathology*; D002648:Child; D018303:Ganglioglioma / Q000473:pathology*; D006801:Humans; D015192:Infratentorial Neoplasms / Q000473:pathology*; D008297:Male; D008527:Medulloblastoma / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*