title: FDG Brain PET/CT Revealing Bilateral Thalamostriatal Activation During a Symptomatic Episode in a Patient With Kleine-Levin Syndrome.
abstract: We report the case of a 14-year-old girl with clinically diagnosed Kleine-Levin syndrome. Electroencephalogram and brain MRI were unremarkable. An FDG PET/CT scan was acquired during a symptomatic episode, while she was asleep, and another PET scan was obtained when she was asymptomatic, awake, and quiet. Comparison of both examinations demonstrated a bilateral activation of thalami, caudate nuclei, and lenticular nuclei. These findings may be linked to the implication of thalamostriatal structures in the regulation of sleep and wakefulness.
authors.affiliation: From the *Department of Nuclear Medicine, University Hospital Jean Minjoz, Besançon; †University of Bourgogne Franche-Comté; ‡EA 4662-Nanomedicine Lab, Imagery and Therapeutics, Besançon; §Service de Médecine Nucléaire, CHU Brabois, Nancy; ∥Nancyclotep Imaging Platform, Nancy; ¶IADI, INSERM U947, Nancy; **Service Central de Biophysique et Médecine Nucléaire, Hôpital de la Timone, APHM, Marseille; ††Aix-Marseille Univ, INT, CNRS UMR 7289, Marseille; and ‡‡Aix-Marseille Univ, CERIMED, Marseille, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Drouet
authors.forename: Olivier
authors.initials: O
authors.lastname: Morel
authors.forename: Antoine
authors.initials: A
authors.lastname: Verger
authors.forename: Eric
authors.initials: E
authors.lastname: Guedj
authors.forename: Hatem
authors.initials: H
authors.lastname: Boulahdour
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D017593:Kleine-Levin Syndrome / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18