title: Ultrasound diagnosis of fetal thanatophoric skeletal dysplasia: Three cases report and a brief review.
abstract: Congenital skeletal deformity of fetus varies and may be attributed to a range of reasons. Congenital skeletal deformity seriously affects body function or even leads to neonatal death directly. The disease brings great pain to victim and their family. We reviewed the fetal prenatal ultrasonic data conducted during period from Jan. 2013 to June 2016, and there were 84 fetuses with skeletal abnormalities among 12 000 cases, and 3 fetuses with thanatophoric dysplasia. Our report described and reviewed three common types of thanatophoric dysplasia, aiming to explore the value of standardized prenatal ultrasonic diagnosis of fetal abnormalities in the skeletal system.
authors.affiliation: Renmin Hospital of Wuhan University, Wuhan, 430070, China.
authors.forename: Qing-Hong
authors.initials: QH
authors.lastname: Zhao
authors.affiliation: Renmin Hospital of Wuhan University, Wuhan, 430070, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Shi
authors.affiliation: Renmin Hospital of Wuhan University, Wuhan, 430070, China.
authors.forename: Jia-Qi
authors.initials: JQ
authors.lastname: Hu
authors.affiliation: Renmin Hospital of Wuhan University, Wuhan, 430070, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Renmin Hospital of Wuhan University, Wuhan, 430070, China.
authors.forename: Gui
authors.initials: G
authors.lastname: Fang
authors.affiliation: Renmin Hospital of Wuhan University, Wuhan, 430070, China.
authors.forename: Yu-Guo
authors.initials: YG
authors.lastname: Zhang
authors.affiliation: Renmin Hospital of Wuhan University, Wuhan, 430070, China.
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Wang
authors.affiliation: Renmin Hospital of Wuhan University, Wuhan, 430070, China. dryangqing@hotmail.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012680:Sensitivity and Specificity; D013796:Thanatophoric Dysplasia / Q000000981:diagnostic imaging*; D016216:Ultrasonography, Prenatal / Q000379:methods*
keywords: congenital skeletal deformity; fetal prenatal ultrasound; fetal skeletal system