title: Is faecal microbiota transplantation an option to eradicate highly drug-resistant enteric bacteria carriage?
abstract: Carbapenem-resistant Enterobacteriaceae (CRE) or vancomycin-resistant enterococci (VRE) carriage present a major public health challenge. Decolonization strategies are lacking. We aimed to evaluate the impact of faecal microbiota transplantation (FMT) on a cohort of patients with digestive tract colonization by CRE or VRE. Eight patients were included: six carrying CRE and two colonized by VRE. One month after FMT, two patients were free from CRE carriage, and another patient was free from VRE after three months. In our experience, this strategy is safe.
authors.affiliation: Infectious Diseases Unit, Raymond Poincaré Teaching Hospital, APHP, Versailles Saint-Quentin University, Garches, France.
authors.forename: B
authors.initials: B
authors.lastname: Davido
authors.affiliation: Pharmacy Department, Cochin Teaching Hospital, APHP, Paris Descartes University, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Batista
authors.affiliation: Pharmacy Department, Raymond Poincaré Teaching Hospital, APHP, Versailles Saint-Quentin University, Garches, France.
authors.forename: H
authors.initials: H
authors.lastname: Michelon
authors.affiliation: Microbiology Laboratory, Raymond Poincaré Teaching Hospital, APHP, Versailles Saint-Quentin University, Garches, France.
authors.forename: M
authors.initials: M
authors.lastname: Lepainteur
authors.affiliation: Pharmacy Department, Raymond Poincaré Teaching Hospital, APHP, Versailles Saint-Quentin University, Garches, France.
authors.forename: F
authors.initials: F
authors.lastname: Bouchand
authors.affiliation: Antimicrobial Stewardship Unit, Henri Mondor Teaching Hospital, APHP, Paris-Est Créteil-Est University, Créteil, France.
authors.forename: R
authors.initials: R
authors.lastname: Lepeule
authors.affiliation: Infectious Diseases Unit, Raymond Poincaré Teaching Hospital, APHP, Versailles Saint-Quentin University, Garches, France.
authors.forename: J
authors.initials: J
authors.lastname: Salomon
authors.affiliation: Infectious Diseases Unit, Bicêtre Teaching Hospital, APHP, Paris-Sud University, Le Kremlin-Bicêtre, France.
authors.forename: D
authors.initials: D
authors.lastname: Vittecoq
authors.affiliation: Infectious Diseases Unit, Raymond Poincaré Teaching Hospital, APHP, Versailles Saint-Quentin University, Garches, France.
authors.forename: C
authors.initials: C
authors.lastname: Duran
authors.affiliation: Infectious Diseases Unit, Bicêtre Teaching Hospital, APHP, Paris-Sud University, Le Kremlin-Bicêtre, France.
authors.forename: L
authors.initials: L
authors.lastname: Escaut
authors.affiliation: Gastroenterology Department, Henri Mondor Teaching Hospital, APHP, Paris-Est Créteil-Est University, Créteil, France.
authors.forename: I
authors.initials: I
authors.lastname: Sobhani
authors.affiliation: Pharmacy Department, Henri Mondor Teaching Hospital, APHP, Paris-Est Créteil-Est University, Créteil, France.
authors.forename: M
authors.initials: M
authors.lastname: Paul
authors.affiliation: Microbiology Laboratory, Raymond Poincaré Teaching Hospital, APHP, Versailles Saint-Quentin University, Garches, France.
authors.forename: C
authors.initials: C
authors.lastname: Lawrence
authors.affiliation: Infectious Diseases Unit, Raymond Poincaré Teaching Hospital, APHP, Versailles Saint-Quentin University, Garches, France.
authors.forename: C
authors.initials: C
authors.lastname: Perronne
authors.affiliation: Pharmacy Department, Cochin Teaching Hospital, APHP, Paris Descartes University, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Chast
authors.affiliation: Infectious Diseases Unit, Raymond Poincaré Teaching Hospital, APHP, Versailles Saint-Quentin University, Garches, France. Electronic address: aurelien.dinh@aphp.fr.
authors.forename: A
authors.initials: A
authors.lastname: Dinh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002353:Carrier State / Q000382:microbiology* / Q000628:therapy*; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000382:microbiology / Q000628:therapy; D000069467:Fecal Microbiota Transplantation / Q000379:methods*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D016896:Treatment Outcome; D065507:Vancomycin-Resistant Enterococci / Q000302:isolation & purification*
keywords: Antimicrobials; Carbapenem-resistant Enterobacteriaceae; Faecal microbiota transplantation; Multidrug-resistant organism; Vancomycin-resistant enterococci