title: Anti-inflammatory 2-(2-phenylethyl)chromone derivatives from Chinese agarwood.
abstract: Five new 2-(2-phenylethyl)chromone derivatives (1-5), along with eleven known compounds (6-16) were isolated from Chinese agarwood. Their structures were elucidated by spectroscopic data (NMR, UV, IR, and MS) analyses and comparison of their spectroscopic and physical data with the literature values. The absolute configurations of 2-4 were determined by electronic circular dichroism (ECD) calculations. Compounds 2-4, 11, 12, and 15 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells with IC50values in the range 1.6-7.3μM.
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors.forename: Hui-Xia
authors.initials: HX
authors.lastname: Huo
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors.forename: Yu-Fan
authors.initials: YF
authors.lastname: Gu
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Sun
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Zhang
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Liu
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors.forename: Zhi-Xiang
authors.initials: ZX
authors.lastname: Zhu
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors.forename: She-Po
authors.initials: SP
authors.lastname: Shi
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors.forename: Yue-Lin
authors.initials: YL
authors.lastname: Song
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, People's Republic of China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Jin
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China. Electronic address: yunfang.zhao@163.com.
authors.forename: Yun-Fang
authors.initials: YF
authors.lastname: Zhao
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Tu
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China. Electronic address: drlj666@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D000067996:RAW 264.7 Cells; D029645:Thymelaeaceae / Q000737:chemistry*; D014934:Wood / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D009569:Nitric Oxide; C062550:2-(2-phenylethyl)chromone
keywords: 2-(2-phenylethyl)chromone; Anti-inflammatory activity; Aquilaria sinensis; Chinese agarwood; Electronic circular dichroism