title: Analysis of risk factors in patients with leukoaraiosis.
abstract: To investigate the risk factors for leukoaraiosis (LA) and the correlation between risk factors and LA.The study comprised 92 patients with diagnoses of LA (LA group) and 56 non-LA individuals (control group). Data were collected for the following: age, gender, fasting blood glucose, total cholesterol, triglyceride, high- and low-density lipoprotein cholesterol, uric acid, creatinine, and histories of smoking, hypertension, and diabetes. Levels of serum asymmetric dimethylarginine (ADMA) were detected by enzyme-linked immunosorbent assay.Univariate analysis showed statistical significance between the 2 groups in age, histories of hypertension and smoking, uric acid, creatinine, and levels of serum ADMA (P < 0.05). Binary logistic analysis showed that age (P < 0.0001), hypertension (P = 0.0101), and serum ADMA (P = 0.0206) were related to LA. Pearson correlation analysis showed that levels of serum ADMA correlated with uric acid (r = 0.184, P = 0.025) and creatinine (r = 0.169, P = 0.04).Age, hypertension, and levels of serum ADMA were independent risk factors for LA. Serum ADMA levels may be related to uric acid and creatinine.
authors.affiliation: Department of Geriatrics, Harbin Medical University, Harbin, China.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Guan
authors.forename: Chaoqi
authors.initials: C
authors.lastname: Yan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Gao
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Hong
authors.forename: Xiuhai
authors.initials: X
authors.lastname: Zheng
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Song
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.forename: Meiling
authors.initials: M
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Fan
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
mesh_terms: D000367:Age Factors; D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D001774:Blood Chemical Analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D049292:Leukoaraiosis / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: C018524:N,N-dimethylarginine; D001120:Arginine