title: Effects of local vibration and pulsed electromagnetic field on bone fracture: A comparative study.
abstract: The effectiveness of various therapeutic methods on bone fracture has been demonstrated in several studies. In the present study, we tried to evaluate the effect of local low-magnitude, high-frequency vibration (LMHFV) on rat tibia fracture in comparison with pulsed electromagnetic fields (PEMF) during the healing process. Mid-diaphysis tibiae fractures were induced in 30 Sprague-Dawley rats. The rats were assigned into groups such as control (CONT), LMHFV (15 min/day, 7 days/week), and PEMF (3.5 h/day, 7 days/week) for a three-week treatment. Nothing was applied to control group. Radiographs, serum osteocalcin levels, and stereological bone analyses of the three groups were compared. The X-rays of tibiae were taken 21 days after the end of the healing process. PEMF and LMHFV groups had more callus formation when compared to CONT group; however, the difference was not statistically significant (P = 0.375). Serum osteocalcin levels were elevated in the experimental groups compared to CONT (P ≤ 0.001). Stereological tests also showed higher osteogenic results in experimental groups, especially in LMHFV group. The results of the present study suggest that application of direct local LMHFV on fracture has promoted bone formation, showing great potential in improving fracture outcome. Bioelectromagnetics. 38:339-348, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Physiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors.forename: Hakkı Murat
authors.initials: HM
authors.lastname: Bilgin
authors.affiliation: Department of Physiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors.forename: Ferhat
authors.initials: F
authors.lastname: Çelik
authors.affiliation: Orthopedics and Traumatology, Dicle University, Diyarbakir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gem
authors.affiliation: Biophysics, Dicle University, Diyarbakir, Turkey.
authors.forename: Veysi
authors.initials: V
authors.lastname: Akpolat
authors.affiliation: Biostatistics, Dicle University, Diyarbakir, Turkey.
authors.forename: İsmail
authors.initials: İ
authors.lastname: Yıldız
authors.affiliation: Biochemistry, Dicle University, Diyarbakir, Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Ekinci
authors.affiliation: Department of Electrical & Electronics Engineering, Faculty of Engineering, Dicle University, Diyarbakir, Turkey.
authors.forename: Mehmet Siraç
authors.initials: MS
authors.lastname: Özerdem
authors.affiliation: Histology and Embryology, Dicle University, Diyarbakir, Turkey.
authors.forename: Selçuk
authors.initials: S
authors.lastname: Tunik
mesh_terms: D000818:Animals; D002146:Bony Callus / Q000503:physiopathology / Q000528:radiation effects; D017102:Fracture Healing / Q000528:radiation effects; D050723:Fractures, Bone / Q000503:physiopathology* / Q000628:therapy*; D055909:Magnetic Field Therapy; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014732:Vibration
keywords: fracture healing; pulsed electromagnetic field; rats; tibia; vibration