title: Accuracy of transvaginal ultrasonography compared to endometrial biopsy for the etiological diagnosis of abnormal perimenopausal bleeding.
abstract: OBJECTIVE
  Perimenopause is marked by clinical manifestations which disturb everyday life and which may also hide a pathomorphological, more precisely endometrial, substrate. An accurate early diagnosis established by accessible, non-invasive methods is very important for the therapeutic management.
  
  
  METHODS
  The study included 103 patients aged between 41.5-55.11 years, divided into 3 age groups: 40-44 years (n=10), 45-49 years (n=54) and ≥50 years (n=39).
  
  
  RESULTS
  Certain risk factors of endometrial neoplasm or premalignant conditions were evidenced, their accurate identification being useful in limiting the number of patients with abnormal uterine bleeding (AUB) submitted to diagnostic screening. The most common cause of AUB in our study was fibroma, followed by functional causes.
  
  
  CONCLUSIONS
  Transvaginal ultrasound (TVUS) represents a minimally invasive method for the screening of perimenopausal patients with AUB, especially to rule out endometrial adenocarcinoma (EAC). TVUS sensitivity was higher than clinical diagnosis in case of leiomioma, polypi and EAC. TVUS was more accurate in the diagnosis of EAC, polypi and leiomioma.
authors.affiliation: 2nd Department of Obstetrics-Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Renata
authors.initials: R
authors.lastname: Nicula
authors.affiliation: 2nd Department of Obstetrics-Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Doru
authors.initials: D
authors.lastname: Diculescu
authors.affiliation: Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Codruţa Claudia
authors.initials: CC
authors.lastname: Lencu
authors.affiliation: 2nd Department of Obstetrics-Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Răzvan
authors.initials: R
authors.lastname: Ciortea
authors.affiliation: 2nd Department of Obstetrics-Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Carmen Elena
authors.initials: CE
authors.lastname: Bucuri
authors.affiliation: 2nd Department of Obstetrics-Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Ioana Adriana
authors.initials: IA
authors.lastname: Oltean
authors.affiliation: 2nd Department of Obstetrics-Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Ioana Alexandra
authors.initials: IA
authors.lastname: Trif
authors.affiliation: 2nd Department of Obstetrics-Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Dan
authors.initials: D
authors.lastname: Mihu
keywords: endometrial neoplasms; perimenopause; transvaginal ultrasound; uterine hemorrhage