title: Mutational Processes Shaping the Genome in Early Human Embryos.
abstract: In-vitro-fertilized human embryos often acquire large structural and numerical chromosomal abnormalities. Liu et al. now show that multiple smaller copy number variations may also arise in in-vivo-conceived embryos. Analysis of these variations provides insight into the DNA mutational processes occurring in early embryos and the mechanisms underlying them.
authors.affiliation: Department of Human Genetics, University of Leuven, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address: thierry.voet@kuleuven.be.
authors.forename: Thierry
authors.initials: T
authors.lastname: Voet
authors.affiliation: Department of Human Genetics, University of Leuven, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address: joris.vermeesch@kuleuven.be.
authors.forename: Joris R
authors.initials: JR
authors.lastname: Vermeesch
mesh_terms: D002869:Chromosome Aberrations; D056915:DNA Copy Number Variations; D005307:Fertilization in Vitro; D016678:Genome; D006801:Humans; D009154:Mutation