title: [Periprostatic inflammation as a risk factor for the development of vesico-urethral stenosis after radical prostatectomy].
abstract: This article presents results of a study conducted to identify the causes of stenosis in the region of vesico-urethral anastomosis (VUA) after radical prostatectomy (RP). Tissue specimens from removed prostates were evaluated in 115 prostate cancer patients with a favorable postoperative period (group 1) and 5 patients who develop VUA stenosis between 6 months to1 year after RP. It was found that in the group 1 inflammatory infiltration did not basically affect tumor growth zones, was mild and did not spread beyond the prostate. Patients of the group 2 had maximum inflammation, with the inflammatory infiltration localized in the prostate regions, both affected and not affected by the tumor, and periprostatically. Taking into account more severe inflammatory response in the prostate with extracapsular extension of the process and the involvement of periprostatic structures in patients who developed VUA stenosis after RP, compared to those without VUA stenosis, we can consider this phenomenon as a risk factor for stenotic complications in the vesico-urethral segment after RP.
authors.affiliation: Department of Molecular Biology, Institute of Arid Zones of Southern Scientific Center of RAS.|Department of Urology and Human Reproductive Health with Course of Pediatric Urology-Andrology, Scientific Research Institute of Urology and Nephrology, Rostov State Medical University of Minzdrav of Russia.
authors.forename: M B
authors.initials: MB
authors.lastname: Chibichyan
authors.affiliation: Department of Molecular Biology, Institute of Arid Zones of Southern Scientific Center of RAS.|Department of Urology and Human Reproductive Health with Course of Pediatric Urology-Andrology, Scientific Research Institute of Urology and Nephrology, Rostov State Medical University of Minzdrav of Russia.
authors.forename: M I
authors.initials: MI
authors.lastname: Kogan
authors.affiliation: Regional Consultative and Diagnostic Centre Rostov-on-Don.
authors.forename: T O
authors.initials: TO
authors.lastname: Lapteva
authors.affiliation: Department of Urology and Human Reproductive Health with Course of Pediatric Urology-Andrology, Scientific Research Institute of Urology and Nephrology, Rostov State Medical University of Minzdrav of Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Belousov
authors.affiliation: Department of Urology and Human Reproductive Health with Course of Pediatric Urology-Andrology, Scientific Research Institute of Urology and Nephrology, Rostov State Medical University of Minzdrav of Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Ivanov
authors.affiliation: Department of Molecular Biology, Institute of Arid Zones of Southern Scientific Center of RAS.
authors.forename: E A
authors.initials: EA
authors.lastname: Chernogubova
mesh_terms: D003251:Constriction, Pathologic; D006801:Humans; D007249:Inflammation / Q000150:complications; D008297:Male; D011468:Prostatectomy / Q000009:adverse effects; D011471:Prostatic Neoplasms / Q000601:surgery; D012307:Risk Factors; D014525:Urethral Stricture / Q000209:etiology
keywords: fibrosis; inflammation; prostate; prostate cancer; radical prostatectomy; stenosis; vesico-urethral anastomosis