title: Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Liver Transplantation.
abstract: Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an extremely rare cause of hyponatremia post-liver transplantation. A 15-year-old Japanese girl with recurrent cholangitis after Kasai surgery for biliary atresia underwent successful living donor liver transplantation. Peritonitis due to gastrointestinal perforation occurred. Hyponatremia gradually developed but improved after hypertonic sodium treatment. One month later, severe hyponatremia rapidly recurred. We considered the hyponatremia's cause as SIADH. We suspected that tacrolimus was the disease's cause, so we used cyclosporine instead, plus hypertonic sodium plus water intake restriction, which improved the hyponatremia. Symptomatic hyponatremia manifested by SIADH is a rare, serious complication post-liver transplantation.
authors.affiliation: Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors.forename: Kosei
authors.initials: K
authors.lastname: Takagi
authors.forename: Takahito
authors.initials: T
authors.lastname: Yagi
authors.forename: Susumu
authors.initials: S
authors.lastname: Shinoura
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Umeda
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Yoshida
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nobuoka
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Watanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Kuise
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Fuji
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Araki
authors.forename: Toshiyoshi
authors.initials: T
authors.lastname: Fujiwara
mesh_terms: D000293:Adolescent; D002761:Cholangitis / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D016031:Liver Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications; D016559:Tacrolimus / Q000009:adverse effects*; D014667:Vasopressins / Q000378:metabolism
chemical_list: D007166:Immunosuppressive Agents; D014667:Vasopressins; D016559:Tacrolimus
keywords: SIADH; hyponatremia; liver transplantation; syndrome of inappropriate antidiuretic hormone secretion; tacrolimus