title: Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis.
abstract: OBJECTIVE
  To assess the value of magnetic resonance elastography (MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis (AIH).
  
  
  METHODS
  In this retrospective study, 36 patients (19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness (LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologists evaluated morphological features of cirrhosis on conventional magnetic resonance imaging (MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis.
  
  
  RESULTS
  Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease (r= 0.88vs-0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed (3.7 kPavs3.84 kPa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis (0.97vs0.53-0.80,P< 0.01), and cirrhosis (0.98vs0.58-0.80,P< 0.01) and better than conventional MRI for diagnosis of cirrhosis (0.98vs0.78,P= 0.002).
  
  
  CONCLUSIONS
  MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI.
authors.affiliation: Jin Wang, Neera Malik, Meng Yin, Richard L Ehman, Sudhakar K Venkatesh, Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, United States.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Jin Wang, Neera Malik, Meng Yin, Richard L Ehman, Sudhakar K Venkatesh, Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, United States.
authors.forename: Neera
authors.initials: N
authors.lastname: Malik
authors.affiliation: Jin Wang, Neera Malik, Meng Yin, Richard L Ehman, Sudhakar K Venkatesh, Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, United States.
authors.forename: Meng
authors.initials: M
authors.lastname: Yin
authors.affiliation: Jin Wang, Neera Malik, Meng Yin, Richard L Ehman, Sudhakar K Venkatesh, Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, United States.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Smyrk
authors.affiliation: Jin Wang, Neera Malik, Meng Yin, Richard L Ehman, Sudhakar K Venkatesh, Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, United States.
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Czaja
authors.affiliation: Jin Wang, Neera Malik, Meng Yin, Richard L Ehman, Sudhakar K Venkatesh, Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, United States.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Ehman
authors.affiliation: Jin Wang, Neera Malik, Meng Yin, Richard L Ehman, Sudhakar K Venkatesh, Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, United States.
authors.forename: Sudhakar K
authors.initials: SK
authors.lastname: Venkatesh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
keywords: Advanced fibrosis; Autoimmune hepatitis; Cirrhosis; Liver stiffness; Magnetic resonance elastography