title: Appendicular Lean Mass and Mortality among Prefrail and Frail Older Adults.
abstract: Prefrail and frail older adults are a heterogeneous population. The measurement of appendicular lean mass (ALM) may distinguish those at higher versus lower risk of poor outcomes. We examined the relationship between ALM and mortality among prefrail and frail older adults.
  
  
  
  This was a population-based cohort study.
  
  
  
  The Third National Health and Nutrition Survey (NHANES III; 1988-1994).
  
  
  
  Older adults (age ≥65 years) with pre-frailty or frailty defined using the Fried criteria.
  
  
  
  ALM was quantified using bioimpedance analysis. Multivariable-adjusted Cox regression analysis examined the relationship between ALM and mortality. Logistic regression analysis was used to determine if ALM added to age and sex improved the predictive discrimination of five-year and ten-year mortality.
  
  
  
  At baseline, the average age was 74.9 years, 66.7% were female, 86.3% and 13.7% were prefrail and frail, respectively. The mean ALM was 18.9 kg [standard deviation (SD): 5.5]. During a median 8.9 years of follow-up, 1,307 of 1,487 study participants died (87.9%). Higher ALM was associated with a lower risk of mortality. In a multivariable-adjusted regression model that accounted for demographic, behavioral, clinical, physical function, and frailty characteristics, each SD increase in ALM was associated with an 50% lower risk of mortality [Hazard Ratio: 0.50 (95% CI: 0.27-0.92); P=0.026]. The addition of ALM to age and sex improved the predictive discrimination of five-year (P=0.027) and ten-year (P=0.016) mortality.
  
  
  
  ALM distinguishes the risk of mortality among prefrail and frail older adults. Additional research examining ALM as a therapeutic target is warranted.
authors.affiliation: Justin C. Brown, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, 8th Floor, Blockley Hall, Philadelphia, PA 19104, Phone: 215-573-6490, Fax: 251-573-5311, Email: brownjus@mail.med.upenn.edu.
authors.forename: J C
authors.initials: JC
authors.lastname: Brown
authors.forename: M O
authors.initials: MO
authors.lastname: Harhay
authors.forename: M N
authors.initials: MN
authors.lastname: Harhay
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001132:Arm / Q000502:physiology*; D001823:Body Composition / Q000502:physiology*; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D016330:Frail Elderly / Q000706:statistics & numerical data*; D006801:Humans; D007866:Leg / Q000502:physiology*; D008297:Male; D009026:Mortality; D018482:Muscle, Skeletal / Q000502:physiology*; D009749:Nutrition Surveys / Q000706:statistics & numerical data*; D016016:Proportional Hazards Models; D012306:Risk
keywords: Lean mass; bioimpedance analysis; geriatrics; population-based