title: [A cohort study on the epidemiological characteristics of HBeAg sero-clearance in HBeAg positive chronic hepatitis B patients in Jiangsu province from 2012 to 2014].
abstract: Objective:To understand the epidemiological characteristics and influencing factors related to HBeAg sero-clearance in chronic hepatitis B patients so as to provide evidence for regular management on chronic HBV patients.Methods:From 2012 to 2014, a cohort study was conducted among HBeAg positive chronic HBV patients in Jiangsu province. Association between the characteristics and incidence of HBeAg sero-clearance was analyzed by Cox regression method. The changing trend on HBV DNA between patients with HBeAg sero-clearance and those with persistent HBeAg positive status was compared by repeated measure data variance analysis method.Results:In 2012, there were 721 HBeAg positive hepatitis B patients aged (45.2 ± 14.2) years enrolled in this study. By 2014, the follow-up observation period was 1 058 person-years, and 393 cases had lost their HBeAg status, with the rate as 37.2/100 person-years. The HBeAg sero-clearance rate was 32.4/100 person-years in hepatitis B patients who received antiviral treatment. The probability of HBeAg clearance in HBeAg positive hepatitis B patients aged ≥60 year (62.0/100 person-years) was higher than those of aged <20 year (7.0/100 person-years). The rate of HBeAg sero-clearance in HBeAg positive patients with HBV DNA <20 000 IU/ml (75.8/100 person-years) was higher than those whose HBV DNA were ≥200 000 IU/ml (16.1/100 person-years). By Cox regression analysis, the HBV DNA level was an important influencing factor on the progress of HBeAg sero-clearance. Patients with HBV DNA levle as ≥200 000 IU/ml, had a lower HBeAg clearance rate (HR=0.18, 95%CI: 0.13-0.23,P<0.001). Compared to the persistent HBeAg positive group, HBV DNA showed a more dramatic fall in the HBeAg-lost group (P<0.001).Conclusion:The rate of HBeAg sero-clearance among HBeAg positive hepatitis B patients was correlated with age and HBV DNA status of the patients that called for comprehensive management and intervention programs to develop for the HBeAg positive hepatitis B patients with different characteristics.
authors.affiliation: Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
authors.forename: L G
authors.initials: LG
authors.lastname: Zhu
authors.affiliation: Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
authors.forename: J
authors.initials: J
authors.lastname: Jiang
authors.affiliation: School of Public Health, Nanjing Medical University, Nanjing 210029, China.
authors.forename: C
authors.initials: C
authors.lastname: Song
authors.affiliation: Epidemic Prevention Section, Zhangjiagang City Center for Disease Control and Prevention, Zhangjiagang 215600, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Epidemic Prevention Section, Danyang City Center for Disease Control and Prevention, Danyang 212310, China.
authors.forename: J F
authors.initials: JF
authors.lastname: Xu
authors.affiliation: Major Project Executive Office, Taixing City Center for Disease Control and Prevention, Taixing 225400, China.
authors.forename: H J
authors.initials: HJ
authors.lastname: Liu
authors.affiliation: Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
authors.forename: H
authors.initials: H
authors.lastname: Peng
authors.affiliation: Animal Care Facility, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Z B
authors.initials: ZB
authors.lastname: Hu
authors.affiliation: Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
authors.forename: F C
authors.initials: FC
authors.lastname: Zhu
authors.affiliation: School of Public Health, Nanjing Medical University, Nanjing 210029, China.
authors.forename: H B
authors.initials: HB
authors.lastname: Shen
authors.affiliation: Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Zhai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D006509:Hepatitis B; D006513:Hepatitis B e Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000187:drug effects* / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D006513:Hepatitis B e Antigens
keywords: Clearance; Cohort; HBV; Hepatitis B e antigen