title: A critical review on serine protease: Key immune manipulator and pathology mediator.
abstract: Proteolytic activity is fundamental to survival, so it is not surprising that all living organisms have proteases, especially seine protease. This enzyme in its numerous isoforms and homologues, constitutes the quintessential offence and defence factors, in the form of surface proteins, secreted molecules, gut digestive enzymes, venom in specialised glands or plant latex, among other manifestations. Occurring as trypsin, chymotrypsin, elastase, collagenase, thrombin, subtilisin etc., it mediates a diverse array of functions, including pathological roles as inflammatory, coagulatory to haemorrhagic. This review emphasizes that despite the superficial differences in mechanisms, most health issues, be they infectious, allergic, metabolic, or neural have a common conduit. This enzyme, in its various glycosylated forms leads to signal misinterpretations, wreaking havoc. However, organisms are endowed with serine protease inhibitors which might restrain this ubiquitous yet deleterious enzyme. Hence, serine proteases-driven pathogenesis and antagonising role of inhibitors is the focal point of this critical review.
authors.affiliation: Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego 92182, USA. Electronic address: seemabiotech83@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Patel
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D006031:Glycosylation; D006470:Hemorrhage / Q000188:drug therapy*; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation; D007413:Intestinal Mucosa / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D059748:Proteolysis; D057057:Serine Proteases / Q000276:immunology / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000378:metabolism
chemical_list: D015842:Serine Proteinase Inhibitors; D057057:Serine Proteases
keywords: Allergenicity; Glycosylation; Inflammation; Serine protease; Serine protease inhibitors