title: Antithyroid arthritis syndrome.
abstract: Antithyroid arthritis syndrome is a constellation of symptoms of myalgia, arthralgia, arthritis, fever and rash associated with the use of antithyroid medications. We report a case of a patient with severe hyperthyroidism likely secondary to Graves' disease who presented with the abovementioned symptoms after being treated with methimazole (antithyroid medication). Our aim is to increase awareness regarding this uncommon but disabilitating and life-threatening adverse effect of antithyroid medications among clinicians. We also discuss the proposed pathophysiology for this immunological reaction as well as management options in these patients.
authors.affiliation: Department of Endocrinology, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Anar
authors.initials: A
authors.lastname: Modi
authors.affiliation: Department of Emergency Medicine, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Hari
authors.initials: H
authors.lastname: Amin
authors.affiliation: Department of Endocrinology, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Farah
authors.initials: F
authors.lastname: Morgan
mesh_terms: D013956:Antithyroid Agents / Q000009:adverse effects*; D018771:Arthralgia / Q000209:etiology*; D001168:Arthritis / Q000209:etiology*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D005334:Fever / Q000209:etiology*; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D008713:Methimazole / Q000009:adverse effects*; D008875:Middle Aged; D013577:Syndrome
chemical_list: D013956:Antithyroid Agents; D008713:Methimazole