title: [Primary breast sarcomas: About 30 cases treated at Salah-Azaiez institute in Tunisia].
abstract: OBJECTIVE
  To identify retrospectively prognostic factors of primary breast sarcoma and review its treatment modalities.
  
  
  METHODS
  This is a descriptive study on 30 cases of primary breast sarcoma. We carried out a univariate and multivariate analysis correlating clinical, pathological and therapeutic parameters with disease-free survival and overall survival.
  
  
  RESULTS
  The mean age was 46.8 years. The mean tumour size was 10cm. The 30 cases were 18 phyllodes sarcomas, eight angiosarcomas, three liposarcomas and a case of granulocytic sarcoma. Sixteen patients had adjuvant radiotherapy and only seven patients received adjuvant chemotherapy. The median follow-up was 64 months. Overall survival rates at 3 and 5 years were 49.1% and 33.7%. Disease-free survival rates at 3 and 5 years were 22.8% and 15.2% respectively. The analytical study of the following parameters: tumour size and presence or absence of node or distant metastases, showed no correlation with overall survival nor with disease-free survival. Furthermore, adjuvant radiotherapy did not improve overall survival (P=0.298; hazard ratio [HR]=1 [0.982-1.04]) nor disease-free survival (P=0.61; HR=0.942 [0.862-1.029]). By univariate analyses, we identified a correlation between overall survival, surgical margins (>1cm) (P=0005; HR=3.4 [1.217-9.919]) and tumour necrosis (P=0.028; HR=0.099 [0.014-0.682]). We did not find any independent prognostic factor by multivariate analysis.
  
  
  CONCLUSIONS
  The prognosis of primary breast sarcoma seems to depend essentially on optimal surgical excision (margin over 1cm). The only potential histological parameter correlated with the prognosis is the presence of tumour necrosis. The histological subtype should not be considered as a prognostic marker for overall or disease-free survival in patients with primary breast sarcoma.
authors.affiliation: Service d'immuno-histocytologie, institut Salah-Azaiez, boulevard 9-avril, 1006 Bab-Saadoun, Tunis, Tunisie. Electronic address: olfaelamine@yahoo.fr.
authors.forename: O
authors.initials: O
authors.lastname: El Amine Elhadj
authors.affiliation: Service d'oncologie médicale, institut Salah-Azaiez, boulevard 9-avril, 1006 Bab-Saadoun, Tunis, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Nasri
authors.affiliation: Service d'immuno-histocytologie, institut Salah-Azaiez, boulevard 9-avril, 1006 Bab-Saadoun, Tunis, Tunisie.
authors.forename: S
authors.initials: S
authors.lastname: Thabet
authors.affiliation: Service de chirurgie carcinologique, institut Salah-Azaiez, boulevard 9-avril, 1006 Bab-Saadoun, Tunis, Tunisie.
authors.forename: J
authors.initials: J
authors.lastname: Ben Hassouna
authors.affiliation: Service d'immuno-histocytologie, institut Salah-Azaiez, boulevard 9-avril, 1006 Bab-Saadoun, Tunis, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Goucha
authors.affiliation: Service de chirurgie carcinologique, institut Salah-Azaiez, boulevard 9-avril, 1006 Bab-Saadoun, Tunis, Tunisie.
authors.forename: K
authors.initials: K
authors.lastname: Rahal
authors.affiliation: Service d'immuno-histocytologie, institut Salah-Azaiez, boulevard 9-avril, 1006 Bab-Saadoun, Tunis, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Elmay
authors.affiliation: Service d'immuno-histocytologie, institut Salah-Azaiez, boulevard 9-avril, 1006 Bab-Saadoun, Tunis, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Gamoudi
mesh_terms: D000047:Academies and Institutes; D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000628:therapy; D003131:Combined Modality Therapy; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006394:Hemangiosarcoma / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D008080:Liposarcoma / Q000453:epidemiology / Q000628:therapy; D008408:Mastectomy / Q000379:methods; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D003557:Phyllodes Tumor / Q000453:epidemiology / Q000628:therapy; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012509:Sarcoma / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000628:therapy; D023981:Sarcoma, Myeloid / Q000453:epidemiology / Q000628:therapy; D016896:Treatment Outcome; D014416:Tunisia / Q000453:epidemiology; D055815:Young Adult
keywords: Breast; Chirurgie; Prognosis; Pronostic; Radiotherapy; Radiothérapie; Sarcomas; Sarcomes; Sein; Surgery; Therapy; Thérapeutique