title: [Function and modulation of type Ⅱ innate lymphoid cells and their role in chronic upper airway inflammatory diseases].
abstract: Type Ⅱ innate lymphoid cells (ILC2) is a family of innate immune lymphocytes, which provide effective immune responses to cytokines. ILC2 are regulated by the nuclear transcription factor ROR alpha and GATA3, secreting cytokines IL-5 and IL-13, etc. Animal models have shown that ILC2 are involved in allergic diseases, such as asthma and atopic dermatitis, and also play a very important role in the metabolic balance. In addition, recent reports suggest that ILC2 not only play a role in the initial stages of the disease, but also can lead to chronic pathological changes in the disease, such as fibrosis, and may have an effect on acquired immunity. This paper mainly focus in the role and regulation of ILC2 cells, and review the research status of ILC2 in the field of chronic upper airway inflammatory diseases including allergic rhinitis and chronic rhinosinusitis.
authors.affiliation: Department of Otorhinolaryngology of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Otorhinolaryngology of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D002908:Chronic Disease; D016207:Cytokines / Q000276:immunology*; D003876:Dermatitis, Atopic / Q000276:immunology; D050990:GATA3 Transcription Factor; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D018793:Interleukin-13 / Q000276:immunology; D015848:Interleukin-5 / Q000276:immunology; D016131:Lymphocyte Subsets / Q000166:cytology / Q000502:physiology*; D057050:Receptor Tyrosine Kinase-like Orphan Receptors / Q000276:immunology; D065631:Rhinitis, Allergic / Q000276:immunology*; D012852:Sinusitis / Q000276:immunology*
chemical_list: D016207:Cytokines; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; D018793:Interleukin-13; D015848:Interleukin-5; D057050:Receptor Tyrosine Kinase-like Orphan Receptors
keywords: Asthma; Rhinitis; Sinusitis; Type2 innate lymphoid cells