title: Research progress on the plasmid-mediated colistin resistance gene mcr-1.
abstract: mcr-1, the first plasmid-mediated colistin-resistance gene, can mediate polymyxin resistance and be transferred horizontally via plasmids. Many studies have confirmed its distribution via epidemic plasmids (IncI2, IncX4, IncHI2, etc.), as well as mobile genetic elements, among Enterobacteriaceae isolated from animals, humans, and the environment in 35 countries. These studies provide the basis of understanding the complicated mechanism of colistin resistance mediated by MCR-1 and its global dissemination and epidemic properties, and also enrich antimicrobial resistance mechanisms. Here, we review the latest advances in the prevalence, resistance mechanism, transfer mechanism, and genetic environments of mcr-1 in isolates recovered from various samples worldwide. Finally, we discuss the clinical risk and the corresponding solutions, aiming to provide a basis for researchers and clinical scientists to face the serious challenge of antimicrobial resistance together.
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
authors.forename: Ling-xian
authors.initials: LX
authors.lastname: Yi
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
authors.forename: Yi-yun
authors.initials: YY
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
authors.forename: Ren-jie
authors.initials: R
authors.lastname: Wu
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
authors.forename: Zi-sen
authors.initials: ZS
authors.lastname: Liang
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Liu
mesh_terms: D000818:Animals; D003091:Colistin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics*; D029968:Escherichia coli Proteins / Q000235:genetics*; D006801:Humans; D010957:Plasmids
chemical_list: D029968:Escherichia coli Proteins; C000614037:MCR-1 protein, E coli; D003091:Colistin