title: Osteopathic Manipulative Treatment in the Management of Isaacs Syndrome.
abstract: Isaacs syndrome is a rare neuromuscular disorder characterized by chronic muscle stiffness, cramping, fasciculations, myokymia, and hyperhidrosis. Pathogenesis includes autoimmunity, paraneoplastic disorders, genetic predisposition, or toxin exposure. There is no known cure for Isaacs syndrome. This case report describes a patient who had been given the diagnosis of Isaacs syndrome and received osteopathic manipulative treatment to manage fascial and cranial dysfunctions and reduce nervous system hyperexcitability. Long-term decrease of myokymia and reduction of severity and frequency of exacerbations resulted.
authors.forename: Lisa K T
authors.initials: LK
authors.lastname: Shanahan
authors.forename: Selena G M
authors.initials: SG
authors.lastname: Raines
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Coggins
authors.forename: Teanna
authors.initials: T
authors.lastname: Moore
authors.forename: Michael
authors.initials: M
authors.lastname: Carnes
authors.forename: Laura
authors.initials: L
authors.lastname: Griffin
mesh_terms: D018450:Disease Progression; D004576:Electromyography / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D020386:Isaacs Syndrome / Q000175:diagnosis* / Q000534:rehabilitation*; D008297:Male; D026301:Manipulation, Osteopathic / Q000379:methods*; D008875:Middle Aged; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome