title: Targeting Brain-Eating Amoebae Infections.
abstract: Brain infections due to Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri often lead to death. Despite differences in the preferential sites of infection in the brain, the mode of delivery of drugs is often intravenous. Here, we discuss targeted therapeutic approach to affect parasite viability without affecting the host cells, with an eye to improve formulation of drugs and/or administration of drugs against brain-eating amoebae.
authors.affiliation: Department of Biological Sciences, Faculty of Science and Technology, Sunway University , Selangor, 47500, Malaysia.
authors.forename: Naveed Ahmed
authors.initials: NA
authors.lastname: Khan
authors.affiliation: Department of Biological Sciences, Faculty of Science and Technology, Sunway University , Selangor, 47500, Malaysia.
authors.forename: Timothy Yu Yee
authors.initials: TYY
authors.lastname: Ong
authors.affiliation: Department of Biological Sciences, Faculty of Science and Technology, Sunway University , Selangor, 47500, Malaysia.
authors.forename: Ruqaiyyah
authors.initials: R
authors.lastname: Siddiqui
mesh_terms: D000981:Antiprotozoal Agents / Q000008:administration & dosage*; D020808:Central Nervous System Protozoal Infections / Q000188:drug therapy*; D006801:Humans
chemical_list: D000981:Antiprotozoal Agents
keywords: Protist; acanthamoeba; balamuthia; brain infection; central nervous system; free-living amoebae; naegleria