title: One-pot synthesis of silicon based nanoparticles with incorporated phthalocyanine for long-term bioimaging and photo-dynamic therapy of tumors.
abstract: Combining the merits of delivery vectors with drug molecules is one of the key directions for development of efficient cancer monitoring and treatment techniques. In this work, a novel type of silicon based composite nanoparticles (NPs) with incorporated hydrophobic phthalocyanine molecules (Pc) was synthesized via a facile one-pot method. The as-synthesized Pc@Si NPs, with a small size of 4.2 ± 0.8 nm, have excellent dispersibility in water and good biocompatibility with cells, in addition to favorable photoluminescence and robust photostability even in cells. Moreover, the Pc@Si NPs show significant in vitro cancer cell killing and in vivo tumor inhibiting abilities upon near-infrared light exposure, due to the photodynamic therapy (PDT) effect of Pc. This work develops an efficient fluorescent PDT drug carrier; moreover, the facile one-pot synthesis strategy may be used generally to prepare silicon-based composite NPs incorporated with diverse hydrophobic drugs/diagnostic molecules for a wide range of biomedical applications.
authors.affiliation: College of Physics, Optoelectronics and Energy, Center for Soft Condensed Matter Physics and Interdisciplinary Research, Soochow University, Suzhou 215006, People's Republic of China.
authors.forename: Jiaojiao
authors.initials: J
authors.lastname: Liu
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Sicong
authors.initials: S
authors.lastname: Wu
authors.forename: Bing
authors.initials: B
authors.lastname: Yuan
authors.forename: Meimei
authors.initials: M
authors.lastname: Bao
authors.forename: Jingliang
authors.initials: J
authors.lastname: Li
authors.forename: Yujiang
authors.initials: Y
authors.lastname: Dou
authors.forename: Yao
authors.initials: Y
authors.lastname: He
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D003952:Diagnostic Imaging; D004705:Endocytosis; D005453:Fluorescence; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D010778:Photochemotherapy; D045663:Quantum Dots / Q000737:chemistry; D012825:Silicon / Q000737:chemistry*
chemical_list: D007211:Indoles; D054833:Isoindoles; C013647:phthalocyanine; D012825:Silicon