title: Speeding up enzyme engineering computationally.
abstract: Canin silicoengineering speed up the delivery of biocatalysts for the burgeoning bioeconomy? In this issue, Kamerlin and coworkers introduceCADEE[Amreinet al.(2017),IUCrJ,4, 50-64] - a framework for Computer-Aided Directed Evolution of Enzymes - that promises to lessen the burden on 'wet lab' enzymologists when optimizing biocatalysts using laboratory-based directed evolution methods.
authors.affiliation: Synthetic Biology Research Centre for Fine and Speciality Chemicals, Manchester Institute of Biotechnology and School of Chemistry, The University of Manchester, Manchester Institute of Biotechnology , 131 Princess Street, Manchester M1 7DN, UK.
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Scrutton
keywords: CADEE; computational directed evolution; computational enzyme design; distributed computing; empirical valence bond; triosephosphate isomerase