title: Cytotoxic gold(iii) complexes incorporating a 2,2':6',2''-terpyridine ligand framework - the impact of the substituent in the 4'-position of a terpy ring.
abstract: Two gold(iii) complexes incorporating 2,2':6',2''-terpyridine derivatives have been synthesised and characterized, and the possibility of tuning the cytotoxic activity by structural modifications of a terpy ligand has been examined. Both complexes [AuCl(4'-R1-terpy)](PF6)2(1) and [AuCl(4'-R2-terpy)](PF6)2(2), where R1is 2-pyridyl and R2is 3-pyridyl, show good anti-proliferative activities against HCT116, which are higher in relation to those of the free ligands, [AuCl(terpy)](PF6)2and standard anticancer drug cisplatin. The cytotoxic properties of the gold complexes were examined by MTS assay, cell cycle and apoptosis analysis, ROS measurements, determination of mitochondrial membrane potential and mass, and staining of phosphatidylserine with Annexin-V antibody FITC-conjugated together with PI.
authors.affiliation: Department of Crystallography, Institute of Chemistry, University of Silesia, 9th Szkolna St, 40-006 Katowice, Poland. bmachura@poczta.onet.pl.
authors.forename: K
authors.initials: K
authors.lastname: Czerwińska
authors.affiliation: August Chełkowski Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland and Silesia Center for Education and Interdisciplinary Research, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland. agnieszka.szurko@us.edu.pl.
authors.forename: M
authors.initials: M
authors.lastname: Golec
authors.affiliation: Silesian University of Technology, Center Biotechnology Bioengineering and Bioinformatics, Gliwice, Poland and Silesian University of Technology, Institute of Automatic Control, Gliwice, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Skonieczna
authors.affiliation: Department of Crystallography, Institute of Chemistry, University of Silesia, 9th Szkolna St, 40-006 Katowice, Poland. bmachura@poczta.onet.pl.
authors.forename: J
authors.initials: J
authors.lastname: Palion-Gazda
authors.affiliation: August Chełkowski Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland and Silesia Center for Education and Interdisciplinary Research, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland. agnieszka.szurko@us.edu.pl.
authors.forename: D
authors.initials: D
authors.lastname: Zygadło
authors.affiliation: Department of Inorganic, Organometallic Chemistry and Catalysis, Institute of Chemistry, University of Silesia, 9th Szkolna St., 40-006 Katowice, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Szlapa-Kula
authors.affiliation: Department of Inorganic, Organometallic Chemistry and Catalysis, Institute of Chemistry, University of Silesia, 9th Szkolna St., 40-006 Katowice, Poland.
authors.forename: S
authors.initials: S
authors.lastname: Krompiec
authors.affiliation: Department of Crystallography, Institute of Chemistry, University of Silesia, 9th Szkolna St, 40-006 Katowice, Poland. bmachura@poczta.onet.pl.
authors.forename: B
authors.identifier: http://orcid.org/0000-0003-0168-5753
authors.initials: B
authors.lastname: Machura
authors.affiliation: August Chełkowski Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland and Silesia Center for Education and Interdisciplinary Research, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland. agnieszka.szurko@us.edu.pl.
authors.forename: A
authors.initials: A
authors.lastname: Szurko