title: Nucleophilic ipso-Substitution of Aryl Methyl Ethers through Aryl C-OMe Bond Cleavage; Access to Functionalized Bisthiophenes.
abstract: A metal and solvent free strategy to functionalize aryl methyl ethers through direct nucleophilic substitution of aryl C-OMe bond has been described. A wide range of O, S, N, and C-centered uncharged nucleophiles has been successfully employed. Using this protocol, functional derivatives of bisthiophene have been synthesized in a straightforward way. The reactions are highly atom-efficient and generate methanol as the only byproduct.
authors.affiliation: Division of Molecular Synthesis and Drug Discovery, Centre of Bio-Medical Research, SGPGIMS Campus , Raebareli Road, Lucknow 226014, India.
authors.forename: Abhishek Kumar
authors.initials: AK
authors.lastname: Mishra
authors.affiliation: Division of NMR and Metabolomics, Centre of Bio-Medical Research, SGPGIMS Campus , Raebareli Road, Lucknow 226014, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Verma
authors.affiliation: Division of Molecular Synthesis and Drug Discovery, Centre of Bio-Medical Research, SGPGIMS Campus , Raebareli Road, Lucknow 226014, India.
authors.forename: Srijit
authors.identifier: 0000-0003-2363-7381
authors.initials: S
authors.lastname: Biswas