title: The role of NM23 in patients with colorectal cancer: A systematic review and meta-analysis.
abstract: This meta-analysis was carried out to evaluate the relationship between NM23 expression and the prognosis of patients with colorectal cancer. We searched PubMed, EMBASE and Web of Science for relevant articles. The pooled odd ratios (ORs) and corresponding 95%CI were calculated to evaluate the prognostic value of NM23 expression in patients with colorectal cancer, and the association between NM23 expression and clinicopathological factors. In total, 2289 patients were pooled from 24 available studies. The incorporative OR combined by 16 studies with overall survival showed that high NM23 expression was associated with better overall survival (OR=0.67, 95%CI: 0.49-0.93, P=0.02, I2=56%, Ph=0.004). And a new estimate without heterogeneity was produced when only combining high-quality studies (OR=0.70, 95%CI: 0.56-0.86, P=0.0007, I2=46%). In disease free survival (DFS), we also obtained a good prognosis (OR=0.30, 95%CI: 0.14-0.68, P=0.004). Although we failed to find any significance in N status (P=0.10), elevated NM23 expression was related to well tumor differentiation (OR=0.60, 95%CI: 0.44-0.820, P=0.001) and Dukes' A&B (OR=0.55, 95%CI: 0.32-0.95, P=0.03). These results indicated that over-expressed NM23 might be an indicator of good prognosis, well tumor differentiation and Dukes' A&B of patients with colorectal cancer, but no significance was found in N status.
authors.affiliation: Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.affiliation: Department of Urinary Surgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, 215300, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Cao
authors.affiliation: Department of Urinary Surgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, 215300, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, China.
authors.forename: Yong-Wei
authors.initials: YW
authors.lastname: Hu
authors.affiliation: Department of Radiotherapy and Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, China.
authors.forename: Min-Bin
authors.initials: MB
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, China. dinghouzhong@163.com.
authors.forename: Hou-Zhong
authors.initials: HZ
authors.lastname: Ding
mesh_terms: D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D018572:Disease-Free Survival; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D054778:NM23 Nucleoside Diphosphate Kinases / Q000378:metabolism*; D009367:Neoplasm Staging; D016017:Odds Ratio; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D054778:NM23 Nucleoside Diphosphate Kinases; C517938:NME1 protein, human
keywords: NM23; colorectal cancer; prognosis; survival and meta-analysis