title: Downregulation of YAP in Clear Cell Renal Cell Carcinoma Contributes to Poor Prognosis and Progressive Features.
abstract: OBJECTIVE
  To investigate the expression of Yes-associated protein (YAP) in clear cell renal cell carcinoma (ccRCC) and its clinical/prognostic significance.
  
  
  METHODS
  The expression of YAP protein was evaluated in tissue microarray by immunohistochemistry. Correlation between YAP expression and clinicopathological characteristics of renal cell carcinoma was analyzed.
  
  
  RESULTS
  Downregulation of YAP protein was observed in ccRCC samples (P=0.0311). Downregulation of YAP expression was correlated with higher T classification, higher clinical stage, and poorer differentiation (P<0.05).
  
  
  CONCLUSIONS
  Downregulation of YAP in clear cell renal cell carcinoma (ccRCC) may contribute to poor prognosis and progressive features.
authors.affiliation: Department of Urology, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai, China xiaoyonghu@126.com.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Pathology, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Urology, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000473:pathology*; D018450:Disease Progression; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010750:Phosphoproteins / Q000378:metabolism*; D011379:Prognosis; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human
keywords: Clear cell renal cell carcinoma (ccRCC); Prognosis; Yes-associated protein (YAP)