title: Organocatalytic Fluorogenic Synthesis of Chromenes.
abstract: Two fluorescent derivatives of 2-amino-3-carbonitrile-4H-chromene were synthesized by means of a fluorogenic Michael addition of dimedone to dicyano alkene labeled BODIPY derivatives. Different organocatalysts were used in different conditions to obtain compounds 3 and 4 in good yield (up to 65% and 85%) and moderate enantiomeric excess (51% and 41% ee, respectively). This work provides the first example of an enantioselective organocatalytic conversion combined with fluorogenesis.
authors.affiliation: van 't Hoff Institute for Molecular Sciences, University of Amsterdam, PO Box 94157, 1090 GD, Amsterdam, The Netherlands.
authors.forename: Mina
authors.initials: M
authors.lastname: Raeisolsadati Oskouei
authors.affiliation: van 't Hoff Institute for Molecular Sciences, University of Amsterdam, PO Box 94157, 1090 GD, Amsterdam, The Netherlands. A.M.Brouwer@uva.nl.
authors.forename: Albert M
authors.initials: AM
authors.lastname: Brouwer
keywords: Chromene; Fluorescence spectroscopy; Fluorogenic reaction; Organocatalysis