title: Macrophage function in obesity-induced inflammation and insulin resistance.
abstract: The steadily increasing obesity epidemic affects currently 30% of western populations and is causative for numerous disorders. It has been demonstrated that immune cells such as macrophages reside in or infiltrate metabolic organs under obese conditions and cause the so-called low-grade inflammation or metaflammation that impairs insulin action thus leading to the development of insulin resistance. Here, we report on data that specifically address macrophage biology/physiology in obesity-induced inflammation and insulin resistance.
authors.affiliation: Institute of Innate Immunity, University Hospital, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
authors.forename: Mario A R
authors.initials: MA
authors.lastname: Lauterbach
authors.affiliation: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD); Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne, Max Planck Institute for Metabolism Research Cologne, University of Cologne, Gleueler Straße 50, 50931, Cologne, Germany. thomas.wunderlich@sf.mpg.de.
authors.forename: F Thomas
authors.identifier: 0000-0002-9209-3501
authors.initials: FT
authors.lastname: Wunderlich
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D007333:Insulin Resistance / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D009765:Obesity / Q000473:pathology*
keywords: Macrophage; Metaflammation; Polarization