title: Effect of serum albumin on the prognosis of elderly patients with stage 3-4 chronic kidney disease.
abstract: OBJECTIVE
  To investigate the influence of serum albumin on the prognosis of elderly patients with stage 3-4 chronic kidney disease (CKD).
  
  
  METHODS
  From July 2013 to November 2015, elderly CKD patients (≥60 years), with eGFR ≥15 mL/min/1.73 m2and <60 mL/min/1.73 m2, with CKD stage 3-4 in the geriatric nephrology clinic were enrolled. General information and underlying diseases were recorded. Laboratory indices were evaluated. Composite endpoint events (CEE) including renal endpoint events, cardiocerebral vascular endpoint events, and death were elucidated. Based on the ROC curves, the patients were divided into lower and higher serum albumin groups (<42.5 and ≥42.5 g/L).
  
  
  RESULTS
  The occurrence of CEEs was significantly higher in lower serum albumin group than those in the higher group. Also, the patients in the higher group were significantly younger with lower urinary protein, blood urea, brain natriuretic peptide, and cystatin C than those in the lower serum albumin group. Contrastingly, hemoglobin, total serum protein, serum calcium, and superoxide dismutase were remarkably higher. The composite endpoints of multifactor logistic regression analysis indicated that as the serum albumin is increased by every 1 g/L, the probability of CEEs would reduce 14.8%, and the risk occurrence rate of the lower serum albumin group was 4.739 fold than the higher group.
  
  
  CONCLUSIONS
  The results suggest that patients with higher serum albumin had a better prognosis than those with lower serum albumin. The low level was an independent risk factor influencing the prognosis of elderly patients in stage 3-4 CKD.
authors.affiliation: Department of Geriatric Medicine, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
authors.forename: Hongru
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Geriatric Medicine, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China. yang1119@ymail.com.
authors.forename: Jihong
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Geriatric Medicine, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
authors.forename: Lili
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Geriatric Medicine, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Department of Geriatric Medicine, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Geriatric Medicine, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Qiu
authors.affiliation: Department of Geriatric Medicine, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Shi
authors.affiliation: Department of Geriatric Medicine, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
authors.forename: Huan
authors.initials: H
authors.lastname: Xi
authors.affiliation: Department of Geriatric Medicine, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002681:China; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D015577:Geriatric Assessment / Q000379:methods*; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007677:Kidney Function Tests; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality; D012189:Retrospective Studies; D018570:Risk Assessment; D012709:Serum Albumin / Q000032:analysis*; D012720:Severity of Illness Index; D012737:Sex Factors; D015996:Survival Rate
chemical_list: D015415:Biomarkers; D012709:Serum Albumin
keywords: CKD; Elderly patients; Prognosis; Serum albumin