title: Dietary supplementation of coenzyme Q10 plus multivitamins to hamper the ROS mediated cisplatin ototoxicity in humans: A pilot study.
abstract: Oxidative stress exerts major role in the pathogenesis of side effects of many antineoplastic drugs, including ototoxicity of cisplatin. In particular, increased levels of reactive oxygen species (ROS) represent one of the molecular mechanisms underlying the apoptosis of different types of hearing cells. Antioxidants and ROS scavengers may thus represent potential therapeutic options to prevent platinum-associated ototoxicity. The aim of this preliminary case-control study was to explore the efficacy of a dietary antioxidant supplement, in order to hamper the occurrences of ototoxicity in patients undergoing cisplatin chemotherapy. As results, a significant protection against cochlear toxic damage was demonstrated in patients who took the antioxidant supplement, which furthermore prevented the occurrence of hearing disorders and tinnitus. These clinical evidences were corroborated by the oxidative status of patients. After cisplatin chemotherapy, the plasma derivatives of reactive oxygen metabolites (d-ROMs) content rapidly increased in control patients, but it was maintained in those under dietary supplementation, likely because of a higher anti-ROMs potential. Indeed, an increment in rapid anti-ROMs was detected in supplemented patients, though no differences were highlighted in terms of slow anti-ROMs. In conclusion, in this preliminary report we demonstrated the feasibility of a dietary antioxidant supplementation in order to prevent the cisplatin induced hearing damage.
authors.affiliation: Department of Otorhinolaryngology, P.A. Micone Hospital, ASL n. 3 Genovese, Genoa - Sestri Ponente, Italy.
authors.forename: Felice
authors.initials: F
authors.lastname: Scasso
authors.affiliation: Department of Clinical and Biological Sciences, Pharmacological Unit, University of Turin, c/o Ospedale San Luigi Gonzaga, Orbassano (TO), Italy.
authors.forename: Andrea Elio
authors.initials: AE
authors.lastname: Sprio
authors.affiliation: Medical Oncology Department, P.A. Micone Hospital, ASL n. 3 Genovese, Genoa - Sestri Ponente, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Canobbio
authors.affiliation: Department of Experimental Medicine (DIMES) - General Pathology Sect. University of Genoa, Genoa, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Scanarotti
authors.affiliation: Scharper Spa, Milan, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Manini
authors.affiliation: Department of Clinical and Biological Sciences, Pharmacological Unit, University of Turin, c/o Ospedale San Luigi Gonzaga, Orbassano (TO), Italy.
authors.forename: Giovanni Nicolao
authors.initials: GN
authors.lastname: Berta
authors.affiliation: Department of Experimental Medicine (DIMES) - General Pathology Sect. University of Genoa, Genoa, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Bassi
keywords: Food science; Human toxicology; Oncology