title: Evaluation of ischemia-modified albumin, oxidative stress, and antioxidant status in acute ischemic stroke patients.
abstract: BACKGROUND
  Oxidative stress is characterized by increased production of reactive oxygen species resulting in the generation of lipid peroxides such as malondialdehyde (MDA). The studies have shown that ischemia-modified albumin (IMA), which has widely been studied as a marker of ischemia, also increases as result of oxidative stress. Hence, the current study was done to evaluate the serum MDA, IMA along with serum uric acid, and albumin, which are important metabolic antioxidants.
  
  
  METHODS
  Fifty patients with acute ischemic stroke were taken as cases and compared with 50 age- and sex-matched controls. Serum MDA, IMA, uric acid, and albumin were estimated both in cases and controls. Serum MDA was estimated by the method of Satoh and IMA by Bar-Oret al. The results were analyzed statistically.
  
  
  RESULTS
  Serum MDA and IMA values were significantly increased in cases (P< 0.0001), whereas serum uric acid and albumin values were significantly decreased (P< 0.05) in comparison to controls. There was also highly significant positive correlation between serum IMA and MDA (r= 0.843,P < 0.0001), whereas there were significant negative correlations between serum IMA and uric acid (r= -0.237,P < 0.05), and albumin (r= -0.326,P < 0.05).
  
  
  CONCLUSIONS
  Hence, we conclude the oxidative stress plays a major role in the etiopathogenesis of acute ischemic stroke, and the deranged oxidant-antioxidant balance further contributes to its severity.
authors.affiliation: Department of Biochemistry, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
authors.forename: Itishri
authors.initials: I
authors.lastname: Jena
authors.affiliation: Department of Biochemistry, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
authors.forename: Sarthak Ranjan
authors.initials: SR
authors.lastname: Nayak
authors.affiliation: Department of Biochemistry, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
authors.forename: Sudeshna
authors.initials: S
authors.lastname: Behera
authors.affiliation: Department of Biochemistry, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
authors.forename: Bratati
authors.initials: B
authors.lastname: Singh
authors.affiliation: Department of Biochemistry, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
authors.forename: Subhashree
authors.initials: S
authors.lastname: Ray
authors.affiliation: Department of Biochemistry, MKCG Medical College, Berhampur University, Berhampur, Odisha, India.
authors.forename: Diptimayee
authors.initials: D
authors.lastname: Jena
authors.affiliation: Department of Medicine, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Singh
authors.affiliation: Department of Pediatrics Surgery, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
authors.forename: Subrat Kumar
authors.initials: SK
authors.lastname: Sahoo
keywords: Acute ischemic stroke; ischemia-modified albumin; malondialdehyde; oxidative stress; reactive oxygen species