title: Vascular and cellular changes accompany altered expression of angiopoietins in placenta of non-complicated ART pregnancies.
abstract: ART is steadily performed for infertility cases and most of the previous researches have focused on complicated pregnancies. Nonetheless, few ones have concerned with placenta of ART in non-complicated pregnancies.
  
  
  
  To investigate the expression of angiopoietins (ANG) and their receptor, TIE-2, in placenta of full-term non-complicated pregnancies having ART (n=28) versus those with spontaneous conception (n=28) together with the histological as well as morphometric analysis.
  
  
  
  While no prominent changes were noticed in the histological structure of the placenta ART pregnancies, it showed a significant decrease (p<0.05) in the percentage of syncytial area and numbers of syncytial knots with insignificant reduction in the placental villous area. Vascular changes in the form of significant decrease (p<0.05) in the chorionic vessel diameter and significant increase (p<0.05) in percentage of vessel area were detected in the ART placenta. In addition, the levels ANG-1, ANG-2 and TIE-2 were significantly increased (p<0.05) in the ART placentas compared with those of SC.
  
  
  
  We demonstrated that there is an altered expression of angiopoietins accompanying the morphometric changes occurring in placenta of ART pregnancies. These changes may indicate vascular and cellular adaptation mechanism for a potential subclinical hypoxia in placenta of ART even in non-complicated pregnancies.
authors.affiliation: Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt. Electronic address: profahmadpasha@mans.edu.eg.
authors.forename: Ahmed A M
authors.initials: AAM
authors.lastname: Abdel-Hamid
authors.affiliation: Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt.
authors.forename: Alaa El-Din L
authors.initials: AEL
authors.lastname: Firgany
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Egypt.
authors.forename: Yaser
authors.initials: Y
authors.lastname: Mesbah
authors.affiliation: Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt.
authors.forename: Mona Fm
authors.initials: MF
authors.lastname: Soliman
mesh_terms: D042683:Angiopoietin-1 / Q000235:genetics / Q000378:metabolism*; D042702:Angiopoietin-2 / Q000235:genetics / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D010920:Placenta / Q000098:blood supply* / Q000378:metabolism*; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D042787:Receptor, TIE-2 / Q000235:genetics / Q000378:metabolism; D027724:Reproductive Techniques, Assisted
chemical_list: C467630:ANGPT1 protein, human; C586513:ANGPT2 protein, human; D042683:Angiopoietin-1; D042702:Angiopoietin-2; D019394:Ki-67 Antigen; D012333:RNA, Messenger; D042787:Receptor, TIE-2
keywords: ANG-1; ANG-2; ART; Full-term non-complicated pregnancy; Placenta; TIE-2