title: In vivo assessment of regional mechanics post-myocardial infarction: A focus on the road ahead.
abstract: Cardiovascular disease, particularly the occurrence of myocardial infarction (MI), remains a leading cause of morbidity and mortality (Go et al.,Circulation127: e6-e245, 2013; Go et al.Circulation129: e28-e292, 2014). There is growing recognition that a key factor for post-MI outcomes is adverse remodeling and changes in the regional structure, composition, and mechanical properties of the MI region itself. However, in vivo assessment of regional mechanics post-MI can be confounded by the species, temporal aspects of MI healing, as well as size, location, and extent of infarction across myocardial wall. Moreover, MI regional mechanics have been assessed over varying phases of the cardiac cycle, and thus, uniform conclusions regarding the material properties of the MI region can be difficult. This review assesses past studies that have performed in vivo measures of MI mechanics and attempts to provide coalescence on key points from these studies, as well as offer potential recommendations for unifying approaches in terms of regional post-MI mechanics. A uniform approach to biophysical measures of import will allow comparisons across studies, as well as provide a basis for potential therapeutic markers.
authors.affiliation: University of South Carolina School of Engineering and Computing, Columbia, South Carolina; ear2007@med.cornell.edu.|Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, South Carolina.
authors.forename: Eva
authors.initials: E
authors.lastname: Romito
authors.affiliation: University of South Carolina School of Engineering and Computing, Columbia, South Carolina.
authors.forename: Tarek
authors.initials: T
authors.lastname: Shazly
authors.affiliation: University of South Carolina School of Engineering and Computing, Columbia, South Carolina.|Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, South Carolina.|Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina; and.|William Jennings Bryan Dorn Veteran Affairs Medical Center, Columbia, South Carolina.
authors.forename: Francis G
authors.initials: FG
authors.lastname: Spinale
mesh_terms: D000818:Animals; D006801:Humans; D008279:Magnetic Resonance Imaging; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D013997:Time Factors; D020257:Ventricular Remodeling
keywords: in vivo; myocardial infarction; myocardial mechanics; regional