title: [Role of angiotensin II receptor type 2 in predicting biochemical recurrence in the treatment of prostate cancer].
abstract: OBJECTIVE
  To identify markers for predicting aggressive forms of prostate cancer.
  
  
  METHODS
  The study retrospectively evaluated expression of angiotensin II type 2 receptors (AT2-R) in prostate needle biopsy tissue from patients with and without biochemical recurrence after combined hormone and radiation therapy.
  
  
  RESULTS
  The study findings showed that low expression of AT2-R in prostate tissue was associated with a high risk of biochemical recurrence. The data on the nature of AT2-R expression in prostate tissue of prostate cancer patients may be considered as a tool for predicting biochemical recurrence after combined hormone and radiation therapy. The test has a sensitivity of 87.5% and specificity of 85.71%.
authors.affiliation: Institute of Arid Zones of Southern Scientific Center of RAS, Rostov-on-Don.|Rostov State Medical University, Rostov-on-Don.
authors.forename: M B
authors.initials: MB
authors.lastname: Chibichyan
authors.affiliation: Institute of Arid Zones of Southern Scientific Center of RAS, Rostov-on-Don.|Rostov State Medical University, Rostov-on-Don.
authors.forename: M I
authors.initials: MI
authors.lastname: Kogan
authors.affiliation: Institute of Arid Zones of Southern Scientific Center of RAS, Rostov-on-Don.|Rostov State Medical University, Rostov-on-Don.
authors.forename: E A
authors.initials: EA
authors.lastname: Chernogubova
authors.affiliation: Rostov Region Pathology and Autopsy Bureau, Rostov-on-Don.
authors.forename: I A
authors.initials: IA
authors.lastname: Pavlenko
authors.affiliation: Institute of Arid Zones of Southern Scientific Center of RAS, Rostov-on-Don.
authors.forename: D G
authors.initials: DG
authors.lastname: Matishov
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D011467:Prostate / Q000737:chemistry / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D044139:Receptor, Angiotensin, Type 2 / Q000032:analysis / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D044139:Receptor, Angiotensin, Type 2
keywords: angiotensin II type 2 receptors; biochemical recurrence; hormone and radiation therapy; prostate cancer; the renin-angiotensin system; tumor markers