title: Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes.
abstract: N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide (NBTCS) was synthesized by condensation reaction of 4-chlorobenzenesulphonyl chloride and 2-aminobenzothiazole in acetone under reflux. Neodymium(III) and thallium(III) complexes of the ligand were also synthesized. Both ligand and metal complexes were characterized using UV-Vis, IR, ¹H- and13C-NMR spectroscopies, elemental analysis and molar conductance measurement. IR studies revealed that the ligand is tridentate and coordinates to the metal ions through nitrogen and oxygen atoms of the sulphonamide group and nitrogen atom attached to benzothiazole ring. The neodymium(III) complex displays a coordination number of eight while thallium(III) complex displays a coordination number of six. The ligand and its complexes were screened in vitro for their antibacterial activities againstEscherichia colistrains (E. coli 6andE. coli 13),Proteusspecies,Staphylococcus aureusandPseudomonas aeruginosausing the agar well diffusion technique. The synthesized compounds were found to be more active against the microorganisms screened relative to ciprofloxacin, gentamicin and co-trimoxazole.
authors.affiliation: Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka 410001, Nigeria. nnamdi.obasi@unn.edu.ng.
authors.forename: Lawrence Nnamdi
authors.initials: LN
authors.lastname: Obasi
authors.affiliation: Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka 410001, Nigeria. susan.oruma@unn.edu.ng.
authors.forename: Uchechukwu Susan
authors.initials: US
authors.lastname: Oruma
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ialsuwidan@ksu.edu.sa.
authors.forename: Ibrahim Abdulrazak
authors.initials: IA
authors.lastname: Al-Swaidan
authors.affiliation: Computational Chemistry Group, Department of Chemistry, Faculty of Science, University of Mauritius, Réduit 80837, Mauritius. ramchemi@intnet.mu.|Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, Johannesburg 2028, South Africa. ramchemi@intnet.mu.
authors.forename: Ponnadurai
authors.initials: P
authors.lastname: Ramasami
authors.affiliation: Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka 410001, Nigeria. chigozie.ezeorah@unn.edu.ng.
authors.forename: Chigozie Julius
authors.initials: CJ
authors.lastname: Ezeorah
authors.affiliation: Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka 410001, Nigeria. alfred.ochonogor@unn.edu.ng.
authors.forename: Alfred Ezinna
authors.initials: AE
authors.lastname: Ochonogor
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D008024:Ligands; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009354:Neodymium / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry*; D013793:Thallium / Q000737:chemistry*; D000096926:Benzenesulfonamides
chemical_list: D000900:Anti-Bacterial Agents; D052160:Benzothiazoles; D056831:Coordination Complexes; D008024:Ligands; D009354:Neodymium; D013449:Sulfonamides; D013793:Thallium; C000620131:N-(benzothiazol-2-yl)-4-chlorobenzenesulphonamide; D000096926:Benzenesulfonamides
keywords: N-(benzothiazol-2-yl)-4-chlorobenzenesulphonamide; antibacterial activity; neodymium(III) and thallium(III) complexes