title: Prevention of Intraabdominal Adhesions: An Experimental Study Using Mitomycin-C and 4% Icodextrin.
abstract: Intraabdominal adhesions remain a significant cause of morbidity and mortality. Moreover, intraabdominal adhesions can develop in more than 50% of abdominal operations.
  
  
  
  We compared the anti-adhesive effects of two different agents on postoperative adhesion formation in a cecal abrasion model.
  
  
  
  Experimental animal study.
  
  
  
  Forty Wistar albino type female rats were anesthetized and underwent laparotomy. Study groups comprised Sham, Control, Mitomycin-C, 4% Icodextrin, and Mitomycin-C +4% Icodextrin groups. Macroscopic and histopathological evaluations of adhesions were performed.
  
  
  
  The frequencies of moderate and severe adhesions were significantly higher in the control group than the other groups. The mitomycin-C and Mitomycin-C +4% Icodextrin groups were associated with significantly lower adhesion scores compared to the control group and 4% Icodextrin group scores (p=0.002 and p=0.008, respectively). The adhesion scores of the Mitomycin-C group were also significantly lower than those of the 4% Icodextrin group (p=0.008).
  
  
  
  Despite its potential for bone marrow toxicity, Mitomycin-C seems to effectively prevent adhesions. Further studies that prove an acceptable safety profile relating to this promising anti-adhesive agent are required before moving into clinical trials.
authors.affiliation: Department of Surgery, Gülhane Training and Research Hospital, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Urkan
authors.affiliation: Department of Surgery, Gülhane Training and Research Hospital, Ankara, Turkey.
authors.forename: İsmail Hakkı
authors.initials: İH
authors.lastname: Özerhan
authors.affiliation: Department of Surgery, Gülhane Training and Research Hospital, Ankara, Turkey.
authors.forename: Aytekin
authors.initials: A
authors.lastname: Ünlü
authors.affiliation: Department of Surgery, Gülhane Training and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Can
authors.affiliation: Department of Surgery, Gülhane Training and Research Hospital, Ankara, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Öztürk
authors.affiliation: Department of Surgical Pathology, Gülhane Training and Research Hospital, Ankara, Turkey.
authors.forename: Armağan
authors.initials: A
authors.lastname: Günal
authors.affiliation: Department of Surgery, Gülhane Training and Research Hospital, Ankara, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Yağcı
mesh_terms: D000477:Alkylating Agents / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D005936:Glucans / Q000494:pharmacology* / Q000627:therapeutic use; D005947:Glucose / Q000494:pharmacology* / Q000627:therapeutic use; D000077607:Icodextrin; D016685:Mitomycin / Q000494:pharmacology* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar / Q000601:surgery; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D000477:Alkylating Agents; D005936:Glucans; D000077607:Icodextrin; D016685:Mitomycin; D005947:Glucose
keywords: 4% icodextrin; Cecal abrasion; intraabdominal adhesions; mitomycin-C