title: Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats.
abstract: Bauhinia holophylla, commonly known as "cow's hoof", is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, the aim of this study was at evaluating the aqueous extract effect of Bauhinia holophylla leaves treatment on the streptozotocin-induced diabetic rats. Diabetes was induced by Streptozotocin (40 mg/Kg) in female Wistar rats. Oral administration of aqueous extract of Bauhinia holophylla leaves was given to non-diabetic and diabetic rats at a dose of 400 mg/kg during 21 days. On day 17 of treatment, the Oral Glucose Tolerance Test was performed to determine the area under the curve. At the end of the treatment, the animals were anesthetized and blood was collected for serum biochemical parameters analysis. After treatment with Bauhinia holophylla extract, non-diabetic and diabetic rats presented no glycemic changes. On the other hand, the plant treatment decreased body weight and increased ALT and AST activities. In conclusion, the treatment with aqueous extract of B. holophylla leaves given to diabetic rats presented no hypoglycemic effect in nondiabetic animals and no antidiabetic effect in diabetic animals with the doses studied. In addition, the diabetic animals treated with the B. holophylla extract showed inconvenient effects and its indiscriminate consumption requires particular carefulness.
authors.affiliation: Laboratório de Fisiologia de Sistemas e Toxicologia Reprodutiva, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso / UFMT, Av. Valdon Varjão, 6390, 78600-000 Barra do Garças, MT, Brazil.
authors.forename: Marcelo S
authors.initials: MS
authors.lastname: Pinheiro
authors.affiliation: Laboratório de Fisiologia de Sistemas e Toxicologia Reprodutiva, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso / UFMT, Av. Valdon Varjão, 6390, 78600-000 Barra do Garças, MT, Brazil.
authors.forename: Luhara S
authors.initials: LS
authors.lastname: Rodrigues
authors.affiliation: Laboratório de Fisiologia de Sistemas e Toxicologia Reprodutiva, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso / UFMT, Av. Valdon Varjão, 6390, 78600-000 Barra do Garças, MT, Brazil.
authors.forename: Leila
authors.initials: L
authors.lastname: S
authors.affiliation: Laboratório de Fisiologia de Sistemas e Toxicologia Reprodutiva, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso / UFMT, Av. Valdon Varjão, 6390, 78600-000 Barra do Garças, MT, Brazil.
authors.forename: Rafaianne Q
authors.initials: RQ
authors.lastname: Moraes-Souza
authors.affiliation: Laboratório de Fisiologia de Sistemas e Toxicologia Reprodutiva, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso / UFMT, Av. Valdon Varjão, 6390, 78600-000 Barra do Garças, MT, Brazil.
authors.forename: Thaigra S
authors.initials: TS
authors.lastname: Soares
authors.affiliation: Laboratório de Fisiologia de Sistemas e Toxicologia Reprodutiva, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso / UFMT, Av. Valdon Varjão, 6390, 78600-000 Barra do Garças, MT, Brazil.
authors.forename: Madileine F
authors.initials: MF
authors.lastname: Américo
authors.affiliation: Laboratório de Fisiologia de Sistemas e Toxicologia Reprodutiva, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso / UFMT, Av. Valdon Varjão, 6390, 78600-000 Barra do Garças, MT, Brazil.
authors.forename: Kleber E
authors.initials: KE
authors.lastname: Campos
authors.affiliation: Laboratório de Pesquisa Experimental de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista / UNESP, Distrito de Rubião Jr. s/n, 18618-970 Botucatu, SP, Brazil.
authors.forename: Débora C
authors.initials: DC
authors.lastname: Damasceno
authors.affiliation: Laboratório de Fisiologia de Sistemas e Toxicologia Reprodutiva, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso / UFMT, Av. Valdon Varjão, 6390, 78600-000 Barra do Garças, MT, Brazil.|Laboratório de Pesquisa Experimental de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista / UNESP, Distrito de Rubião Jr. s/n, 18618-970 Botucatu, SP, Brazil.
authors.forename: Gustavo T
authors.initials: GT
authors.lastname: Volpato
mesh_terms: D000818:Animals; D036481:Bauhinia / Q000737:chemistry*; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004326:Drinking; D004435:Eating; D005260:Female; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013311:Streptozocin; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013311:Streptozocin