title: The Routine Clinical use of Pharmacogenetic Tests: What it Will Require?
abstract: Pharmacogenetic testing aims to personalize drug therapy with a view to optimising drug efficacy and minimise toxicity. However, despite the potential benefits, pharmacogenetic testing is mostly confined to specialised medical areas, laboratories and centres. Widespread integration into routine clinical practice has been limited by a complex set of issues including regulatory and reimbursement frameworks, evidence of clinical utility and clinician perspectives, practices and education. Here we assess the current barriers to widespread clinical uptake and identify the key issue necessary to address to accelerate routine testing.
authors.affiliation: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.|Department of Clinical Pharmacology, School of Medicine, Flinders University, Bedford Park, Australia.
authors.forename: Mafalda M
authors.initials: MM
authors.lastname: Dias
authors.affiliation: Department of Clinical Pharmacology, School of Medicine, Flinders University, Bedford Park, Australia.|Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Sorich
authors.affiliation: Department of Clinical Pharmacology, School of Medicine, Flinders University, Bedford Park, Australia.|Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Rowland
authors.affiliation: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Wiese
authors.affiliation: Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia. ross.mckinnon@flinders.edu.au.
authors.forename: Ross A
authors.initials: RA
authors.lastname: McKinnon
mesh_terms: D054316:Biomarkers, Pharmacological; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods; D000071185:Pharmacogenomic Testing / Q000379:methods*; D057285:Precision Medicine / Q000379:methods
chemical_list: D054316:Biomarkers, Pharmacological
keywords: biomarkers; clinical uptake; diagnostic tests; personalized medicine