title: [Oxytocin administration during spontaneous labour: Guidelines for clinical practice. Guidelines short text].
abstract: OBJECTIVE
  To define the different stages of spontaneous labour. To determine the indications, modalities of use and the effects of administering synthetic oxytocin. And to describe undesirable maternal and perinatal outcomes associated with the use of synthetic oxytocin.
  
  
  METHODS
  A systematic review was carried out by searching Medline database and websites of obstetrics learned societies until March 2016.
  
  
  RESULTS
  The 1st stage of labor is divided in a latence phase and an active phase, which switch at 5cm of cervical dilatation. Rate of cervical dilatation is considered as abnormal below 1cm per 4hour during the first part of the active phase, and below 1cm per 2hours above 7cm of dilatation. During the latent phase of the first stage of labor, i.e. before 5cm of cervical dilatation, it is recommended that an amniotomy not be performed routinely and not to use oxytocin systematically. It is not recommended to expect the active phase of labor to start the epidural analgesia if patient requires it. If early epidural analgesia was performed, the administration of oxytocin must not be systematic. If dystocia during the active phase, an amniotomy is recommended in first-line treatment. In the absence of an improvement within an hour, oxytocin should be administrated. However, in the case of an extension of the second stage beyond 2hours, it is recommended to administer oxytocin to correct a lack of progress of the presentation. If dynamic dystocia, it is recommended to start initial doses of oxytocin at 2mUI/min, to respect at least 30min intervals between increases in oxytocin doses delivered, and to increase oxytocin doses by 2mUI/min intervals without surpassing a maximum IV flow rate of 20mUI/min. The reported maternal adverse effects concern uterine hyperstimulation, uterine rupture and post-partum haemorrhage, and those of neonatal adverse effects concern foetal heart rate anomalies associated with uterine hyperstimulation, neonatal morbidity and mortality, neonatal jaundice, weak suck/poor breastfeeding latch and autism.
  
  
  CONCLUSIONS
  The widespread use of oxytocin during spontaneous labour must not be considered as simply another inoffensive prescription without any possible deleterious consequences for mother or foetus. Conditions for administering the oxytocin must therefore respect medical protocols. Indications and patient consent have to be report in the medical file.
authors.affiliation: Pôle IMER, Réseau périnatal Aurore, hospices civils de Lyon, 69003 Lyon, France; HESPER EA 7425, université Lyon, université Claude-Bernard-Lyon 1, 69008 Lyon, France. Electronic address: corinne.dupont@chu-lyon.fr.
authors.forename: C
authors.initials: C
authors.lastname: Dupont
authors.affiliation: Service de PMI, direction des familles et de la petite enfance, mairie de Paris, 75196 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Carayol
authors.affiliation: Maternité Port Royal, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 75014 Paris, France; Inserm U1153, épidémiologie obstétricale, périnatale et pédiatrique (équipe EPOPé), centre de recherche en épidémiologie et statistiques Sorbonne Paris Cité (CRESS), DHU risques et grossesse, université Paris Descartes, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Le Ray
authors.affiliation: EA 4681 PEPRADE, université d'Auvergne, CHU de Clermont-Ferrand, 63003 Clermont-Ferrand, France.
authors.forename: C
authors.initials: C
authors.lastname: Barasinski
authors.affiliation: Inserm U1085, IRSET, équipe 9 « recherches épidémiologiques sur l'environnement, la reproduction et le développement », 35000 Rennes, France.
authors.forename: R
authors.initials: R
authors.lastname: Beranger
authors.affiliation: CHU de Dijon, 21030 Dijon, France.
authors.forename: A
authors.initials: A
authors.lastname: Burguet
authors.affiliation: Inserm U1153, épidémiologie obstétricale, périnatale et pédiatrique (équipe EPOPé), centre de recherche en épidémiologie et statistiques Sorbonne Paris Cité (CRESS), DHU risques et grossesse, université Paris Descartes, 75014 Paris, France; École de sages-femmes Baudelocque, université Paris Descartes, DHU risques et grossesse, Assistance publique-Hôpitaux de Paris, 75014 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Chantry
authors.affiliation: Inserm U1153, épidémiologie obstétricale, périnatale et pédiatrique (équipe EPOPé), centre de recherche en épidémiologie et statistiques Sorbonne Paris Cité (CRESS), DHU risques et grossesse, université Paris Descartes, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Chiesa
authors.affiliation: Inserm U1153, épidémiologie obstétricale, périnatale et pédiatrique (équipe EPOPé), centre de recherche en épidémiologie et statistiques Sorbonne Paris Cité (CRESS), DHU risques et grossesse, université Paris Descartes, 75014 Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Coulm
authors.affiliation: Association bien naître, 69003 Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Evrard
authors.affiliation: Maternité Port Royal, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Fischer
authors.affiliation: HESPER EA 7425, université Lyon, université Claude-Bernard-Lyon 1, 69008 Lyon, France; Hôpital Femme-Mère-Enfant, hospices civils de Lyon, 69500 Bron, France; Pôle information médicale évaluation recherche, 69003 Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Gaucher
authors.affiliation: Clinique Natecia, 69008 Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Guillou
authors.affiliation: Hôpital Montélimar, 26200 Montélimar, France.
authors.forename: F
authors.initials: F
authors.lastname: Leroy
authors.affiliation: Association d'usagers, collectif inter-associatif autour de la naissance (CIANE), 75014 Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Phan
authors.affiliation: Département de Maïeutique, UFR des sciences de la santé Simone-Veil, université Versailles-Saint-Quentin, 78000 Versailles, France.
authors.forename: A
authors.initials: A
authors.lastname: Rousseau
authors.affiliation: Département hospitalo-universitaire « risques et grossesse », groupe hospitalier Cochin, AP-HP, 53, avenue de l'Observatoire, 75014 Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Tessier
authors.affiliation: EA 4681 PEPRADE, université d'Auvergne, CHU de Clermont-Ferrand, 63003 Clermont-Ferrand, France.
authors.forename: F
authors.initials: F
authors.lastname: Vendittelli
authors.affiliation: Inserm U1153, épidémiologie obstétricale, périnatale et pédiatrique (équipe EPOPé), centre de recherche en épidémiologie et statistiques Sorbonne Paris Cité (CRESS), DHU risques et grossesse, université Paris Descartes, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Deneux-Tharaux
authors.affiliation: Pôle Mère-Femme, CHRU de Besançon, 3, boulevard Fleming, 25000 Besançon, France.
authors.forename: D
authors.initials: D
authors.lastname: Riethmuller
mesh_terms: D005260:Female; D006340:Heart Rate, Fetal / Q000187:drug effects; D006801:Humans; D007747:Labor Stage, First / Q000187:drug effects; D007743:Labor, Obstetric / Q000187:drug effects*; D016239:MEDLINE; D010120:Oxytocics / Q000008:administration & dosage; D010121:Oxytocin / Q000008:administration & dosage* / Q000009:adverse effects; D006473:Postpartum Hemorrhage / Q000139:chemically induced; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D014597:Uterine Rupture / Q000139:chemically induced
chemical_list: D010120:Oxytocics; D010121:Oxytocin
keywords: Adverse effects; Effets indésirables; Indication; Oxytocin; Oxytocine; Spontaneous labour; Travail spontané