title: Abnormal Spontaneous Brain Activity in Women with Premenstrual Syndrome Revealed by Regional Homogeneity.
abstract: Background: Previous studies have revealed that the etiologies of premenstrual syndrome (PMS) refer to menstrual cycle related brain changes. However, its intrinsic neural mechanism is still unclear. The aim of the present study was to assess abnormal spontaneous brain activity and to explicate the intricate neural mechanism of PMS using resting state functional magnetic resonance imaging (RS-fMRI).Materials and Methods: The data of 20 PMS patients (PMS group) and 21 healthy controls (HC group) were analyzed by regional homogeneity (ReHo) method during the late luteal phase of menstrual cycle. In addition, all the participants were asked to complete a daily record of severity of problems (DRSP) questionnaire.Results: Compared with HC group, the results showed that PMS group had increased ReHo mainly in the bilateral precuneus, left inferior temporal cortex (ITC), right inferior frontal cortex (IFC) and left middle frontal cortex (MFC) and decreased ReHo in the right anterior cingulate cortex (ACC) at the luteal phase. Moreover, the PMS group had higher DRSP scores, and the DRSP scores positively correlated with ReHo in left MFC and negatively correlated with ReHo in the right ACC.Conclusion: Our results suggest that abnormal spontaneous brain activity is found in PMS patients and the severity of symptom is specifically related to the left MFC and right ACC. The present findings may be beneficial to explicate the intricate neural mechanism of PMS.
authors.affiliation: Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Liao
authors.affiliation: Department of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Pang
authors.affiliation: Life Science Research Center, School of Life Science and Technology, Xidian University Xi'an, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
authors.forename: Huimei
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
authors.forename: Gaoxiong
authors.initials: G
authors.lastname: Duan
authors.affiliation: Life Science Research Center, School of Life Science and Technology, Xidian University Xi'an, China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
authors.forename: Jien
authors.initials: J
authors.lastname: Tao
authors.affiliation: Department of Teaching, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
authors.forename: Danhong
authors.initials: D
authors.lastname: Wen
authors.affiliation: Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
authors.forename: Lingyan
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
authors.forename: Demao
authors.initials: D
authors.lastname: Deng
keywords: brain; fMRI; premenstrual syndrome; regional homogeneity; resting state