title: Genetic, hematological, and immunological disorders transmissible with liver transplantation.
abstract: It is well recognized that solid organ transplantation can transmit bacterial infection and chronic viral hepatitis as well as certain cancers. As indications for liver transplantation (LT) have expanded, it has been used to treat and even cure certain genetic cholestatic disorders, urea cycle defects, and coagulation abnormalities; many of these conditions are potentially transmissible with LT as well. It is important for clinicians and transplant patients to be aware of these potentially transmissible conditions as unexplained post-LT complications can sometimes be related to donor transmission of disease and thus should prompt a thorough exploration of the donor allograft history. Herein, we will review the reported genetic, metabolic, hematologic, and immunological disorders that are transmissible with LT and describe clinical scenarios in which these cases have occurred, such as in inadvertent or recognized transplantation of a diseased organ, domino transplantation, and with living related liver donation. Liver Transplantation 23 663-678 2017 AASLD.
authors.affiliation: Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
authors.forename: Amy
authors.initials: A
authors.lastname: Tan
authors.affiliation: Recanati/Miller Transplantation Institute, Mount Sinai Medical Center, New York, NY.
authors.forename: Sander S
authors.initials: SS
authors.lastname: Florman
authors.affiliation: Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.|Division of Liver Diseases, Mount Sinai Medical Center, New York, NY.|Recanati/Miller Transplantation Institute, Mount Sinai Medical Center, New York, NY.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Schiano
mesh_terms: D006801:Humans; D008107:Liver Diseases / Q000209:etiology*; D016031:Liver Transplantation / Q000009:adverse effects*