title: The Relationship between Maternal Plasma Leptin and Adiponectin Concentrations and Newborn Adiposity.
abstract: Increased maternal blood concentrations of leptin and decreased adiponectin levels, which are common disturbances in obesity, may be involved in offspring adiposity by programming fetal adipose tissue development. The aim of this study was to assess the relationship between maternal leptin and adiponectin concentrations and newborn adiposity. This was a cross-sectional study involving 210 healthy mother-newborn pairs from a public maternity hospital in São Paulo, Brazil. Maternal blood samples were collected after delivery and leptin and adiponectin concentrations were measured by enzyme-linked immunosorbent assay. Newborn body composition was estimated by air displacement plethysmography. The association between maternal leptin and adiponectin concentrations and newborn adiposity (fat mass percentage, FM%) was evaluated by multiple linear regression, controlling for maternal age, socioeconomic status, parity, pre-pregnancy body mass index (BMI), weight gain, gestational age, and newborn age at the time of measurement. No relationship was found between maternal leptin and FM% of male or female newborn infants. Maternal adiponectin (p= 0.001) and pre-pregnancy BMI (p< 0.001; adj.R² = 0.19) were positively associated with FM% of newborn males, indicating that maternal adiponectin is involved in fetal fat deposition in a sex-specific manner. Large-scale epidemiological, longitudinal studies are necessary to confirm our results.
authors.affiliation: Nutrition Department, School of Public Health, University of São Paulo, São Paulo 01246-904, Brazil. natalia@usp.br.
authors.forename: Natália P
authors.initials: NP
authors.lastname: Castro
authors.affiliation: Postgraduate Program in Applied Human Nutrition (PRONUT), University of São Paulo, São Paulo 05508-000, Brazil. veronicaeuclydes@hotmail.com.
authors.forename: Verônica V
authors.initials: VV
authors.lastname: Euclydes
authors.affiliation: Nutrition Department, School of Public Health, University of São Paulo, São Paulo 01246-904, Brazil. agapito.fe@gmail.com.
authors.forename: Fernanda A
authors.initials: FA
authors.lastname: Simões
authors.affiliation: Immunology Center, Adolfo Lutz Institute, São Paulo 05403-000, Brazil. lourlima@uol.com.
authors.forename: Lourdes R A
authors.initials: LR
authors.lastname: Vaz-de-Lima
authors.affiliation: Immunology Center, Adolfo Lutz Institute, São Paulo 05403-000, Brazil. cbrito@usp.br.
authors.forename: Cyro A
authors.initials: CA
authors.lastname: De Brito
authors.affiliation: Nutrition Department, School of Public Health, University of São Paulo, São Paulo 01246-904, Brazil. lianialuzia@usp.br.
authors.forename: Liania A
authors.initials: LA
authors.lastname: Luzia
authors.affiliation: Institute for Global Health, University College London, London WC1N 1EH, UK. d.devakumar@ucl.ac.uk.
authors.forename: Delan
authors.initials: D
authors.lastname: Devakumar
authors.affiliation: Nutrition Department, School of Public Health, University of São Paulo, São Paulo 01246-904, Brazil. phcrondo@usp.br.|Postgraduate Program in Applied Human Nutrition (PRONUT), University of São Paulo, São Paulo 05508-000, Brazil. phcrondo@usp.br.
authors.forename: Patrícia H C
authors.initials: PH
authors.lastname: Rondó
mesh_terms: D052242:Adiponectin / Q000097:blood*; D050154:Adiposity; D001823:Body Composition; D015992:Body Mass Index; D001938:Brazil; D003430:Cross-Sectional Studies; D005260:Female; D047109:Fetal Development; D006801:Humans; D007231:Infant, Newborn; D020738:Leptin / Q000097:blood*; D016014:Linear Models; D008297:Male; D063766:Pediatric Obesity / Q000097:blood*; D010991:Plethysmography; D011247:Pregnancy; D012959:Socioeconomic Factors; D015430:Weight Gain
chemical_list: D052242:Adiponectin; D020738:Leptin
keywords: adiponectin; adiposity; leptin; mother; newborn