title: Recent developments in drug discovery against the protozoal parasites Cryptosporidium and Toxoplasma.
abstract: Apicomplexan parasites cause some of the most devastating human diseases, including malaria, toxoplasmosis, and cryptosporidiosis. New drug discovery is imperative in light of increased resistance. In this digest article, we briefly explore some of the recent and promising developments in new drug discovery against two apicomplexan parasites, Cryptosporidium and Toxoplasma.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, Warwickshire CV4 7AL, UK.
authors.forename: Prinessa
authors.initials: P
authors.lastname: Chellan
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, Warwickshire CV4 7AL, UK.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Sadler
authors.affiliation: Department of Biological Sciences, University of the Pacific, Stockton, CA 95211, United States. Electronic address: kland@pacific.edu.
authors.forename: Kirkwood M
authors.initials: KM
authors.lastname: Land
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D003457:Cryptosporidiosis / Q000188:drug therapy / Q000469:parasitology; D003458:Cryptosporidium / Q000187:drug effects* / Q000201:enzymology; D026261:Diazepam Binding Inhibitor / Q000037:antagonists & inhibitors; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D014122:Toxoplasma / Q000187:drug effects* / Q000201:enzymology; D014123:Toxoplasmosis / Q000188:drug therapy / Q000469:parasitology
chemical_list: D000981:Antiprotozoal Agents; D026261:Diazepam Binding Inhibitor; D004791:Enzyme Inhibitors