title: Quantitative imaging biomarkers for dural sinus patterns in idiopathic intracranial hypertension.
abstract: To quantitatively characterize transverse dural sinuses (TS) on magnetic resonance venography (MRV) in patients with idiopathic intracranial hypertension (IIH), compared to healthy controls, using a computer assisted detection (CAD) method.
  
  
  
  We retrospectively analyzed MRV studies of 38 IIH patients and 30 controls, matched by age and gender. Data analysis was performed using a specially developed Matlab algorithm for vessel cross-sectional analysis. The cross-sectional area and shape measurements were evaluated in patients and controls.
  
  
  
  Mean, minimal, and maximal cross-sectional areas as well as volumetric parameters of the right and left transverse sinuses were significantly smaller in IIH patients than in controls (p< .005 for all). Idiopathic intracranial hypertension patients showed a narrowed segment in both TS, clustering near the junction with the sigmoid sinus. In 36% (right TS) and 43% (left TS), the stenosis extended to >50% of the entire length of the TS, i.e. the TS was hypoplastic. Narrower vessels tended to have a more triangular shape than did wider vessels.
  
  
  
  Using CAD we precisely quantified TS stenosis and its severity in IIH patients by cross-sectional and volumetric analysis. This method can be used as an exact tool for investigating mechanisms of IIH development and response to treatment.
authors.affiliation: Division of Ophthalmology Sackler Faculty of Medicine Tel Aviv Sourasky Medical Center Tel Aviv University Tel Aviv Israel.
authors.forename: Dinah
authors.initials: D
authors.lastname: Zur
authors.affiliation: Diagnostic Imaging Department Soroka University Medical Center Ben-Gurion University of the Negev Beer-Sheva Israel.
authors.forename: Reut
authors.initials: R
authors.lastname: Anconina
authors.affiliation: Division of Ophthalmology Sackler Faculty of Medicine Tel Aviv Sourasky Medical Center Tel Aviv University Tel Aviv Israel.
authors.forename: Anat
authors.initials: A
authors.lastname: Kesler
authors.affiliation: Zolotowsky Neuroscience Center Ben-Gurion University of the Negev Beer-Sheva Israel.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Lublinsky
authors.affiliation: Clinical Research Center Soroka University Medical Center Ben-Gurion University of the Negev Beer-Sheva Israel.
authors.forename: Ronen
authors.initials: R
authors.lastname: Toledano
authors.affiliation: Diagnostic Imaging Department Soroka University Medical Center Ben-Gurion University of the Negev Beer-Sheva Israel.
authors.forename: Ilan
authors.initials: I
authors.lastname: Shelef
mesh_terms: D000328:Adult; D015415:Biomarkers; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging / Q000473:pathology; D003392:Cranial Sinuses / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D011559:Pseudotumor Cerebri / Q000000981:diagnostic imaging / Q000473:pathology*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: MRI; idiopathic intracranial hypertension; neuro‐ophthalmology