title: [Asymptomatic skull base metastases: clinical course and therapeutic alternatives].
abstract: BACKGROUND
  Skull base metastases (SBM) are an infrequent and late type of cancer progression that are associated to poor prognosis. Its clinical manifestations may be grouped in five clinical syndromes and radiotherapy is its more frequent treatment. Because of the improvement in imaging tests and the close follow up of cancer patients, SBM can be diagnosed incidentally. In this group the best option of treatment has not been established.
  
  
  OBJECTIVE
  To analyze the clinical features and outcomes of patients with SBM diagnosed incidentally.
  
  
  METHODS
  Between January 2012 and December 2015, 31 patients with diagnoses of SBM from solid primary tumor were reviewed.
  
  
  RESULTS
  SBM were diagnosed due to skull base syndromes (n = 24) or incidentally (n = 7). Symptomatic patients were treated with radiotherapy. Patients diagnosed incidentally remained without symptoms of craneal base involvement during the follow up, although they frequently had other types of intracranial progression. A statistically significant difference in survival was observed between symptomatic and asymptomatic patients (p = 0.001).
  
  
  CONCLUSIONS
  The incidentally diagnosed SBM were frequently associated to other types of intracranial progression, limiting the options of treatment.
authors.affiliation: Hospital Clinic de Barcelona, 08036 Barcelona, Espana.
authors.forename: A
authors.initials: A
authors.lastname: Vargas
authors.affiliation: Hospital Clinic de Barcelona, 08036 Barcelona, Espana.
authors.forename: C
authors.initials: C
authors.lastname: Paulazo
authors.affiliation: Hospital Clinic de Barcelona, Barcelona, Espana.
authors.forename: L
authors.initials: L
authors.lastname: Oleaga
authors.affiliation: Hospital Clinic de Barcelona, 08036 Barcelona, Espana.
authors.forename: E
authors.initials: E
authors.lastname: Verger
mesh_terms: D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases; D001943:Breast Neoplasms; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D033162:Incidental Findings; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms; D008279:Magnetic Resonance Imaging; D008297:Male; D010166:Palliative Care; D000072078:Positron Emission Tomography Computed Tomography; D011471:Prostatic Neoplasms; D012189:Retrospective Studies; D019292:Skull Base Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D014057:Tomography, X-Ray Computed