title: Synthesis and Examination of Nanocomposites Based on Poly(2-hydroxyethyl methacrylate) for Medicinal Use.
abstract: Preparation of poly(2-hydroxyethyl methacrylate) (PHEMA) based nanocomposites using different approaches such as synthesis with water as the porogen, filling of polymer matrix by silica and formation of interpenetrating polymer networks with polyurethane was demonstrated. Incorporation of various biologically active compounds (BAC) such as metronidazole, decamethoxin, zinc sulphate, silver nitrate or amino acids glycine and tryptophan into nanocomposites was achieved. BAC were introduced into the polymer matrix either (1) directly, or (2) with a solution of colloidal silica, or (3) through immobilization on silica (sol-densil). Morphology of prepared materials was investigated by laser scanning microscopy and low-vacuum scanning electron microscopy. In vacuum freeze-drying, prior imaging was proposed for improving visualization of the porous structure of composites. The interaction between PHEMA matrix and silica filler was investigated by IR spectroscopy. Adsorption of 2-hydroxyethyl methacrylate and BAC from aqueous solution on the silica surface was also examined. Phase composition and thermal stability of composites were studied by the differential thermogravimetry/differential thermal analysis. Release of BAC into water medium from prepared composites were shown to depend on the synthetic method and differed significantly. Obtained PHEMA-base materials which are characterized by controlled release of BAC have a strong potential for application in manufacturing of different surgical devices like implants, catheters and drainages.
authors.affiliation: Chuiko Institute of Surface Chemistry, NAS of Ukraine, 17 General Naumov Str., Kyiv, 03164, Ukraine. clemans2009@rambler.ru.|Vinnytsia National Pyrogov Memorial Medical University, 56 Pyrogov Str., Vinnytsia, 21018, Ukraine. clemans2009@rambler.ru.
authors.forename: Olena S
authors.initials: OS
authors.lastname: Kukolevska
authors.affiliation: Chuiko Institute of Surface Chemistry, NAS of Ukraine, 17 General Naumov Str., Kyiv, 03164, Ukraine.
authors.forename: Igor I
authors.initials: II
authors.lastname: Gerashchenko
authors.affiliation: Chuiko Institute of Surface Chemistry, NAS of Ukraine, 17 General Naumov Str., Kyiv, 03164, Ukraine.
authors.forename: Mykola V
authors.initials: MV
authors.lastname: Borysenko
authors.affiliation: Chuiko Institute of Surface Chemistry, NAS of Ukraine, 17 General Naumov Str., Kyiv, 03164, Ukraine.
authors.forename: Evgenii M
authors.initials: EM
authors.lastname: Pakhlov
authors.affiliation: Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, Zlin, 76001, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Machovsky
authors.affiliation: Vinnytsia National Pyrogov Memorial Medical University, 56 Pyrogov Str., Vinnytsia, 21018, Ukraine.
authors.forename: Tetyana I
authors.initials: TI
authors.lastname: Yushchenko
keywords: Biologically active compounds; Controlled release; Nanocomposites; Poly(2-hydroxyethyl methacrylate); Pore formation; Silica