title: Real world heart failure epidemiology and outcome: A population-based analysis of 88,195 patients.
abstract: BACKGROUND
  Heart failure (HF) is frequent and its prevalence is increasing. We aimed to evaluate the epidemiologic features of HF patients, the 1-year follow-up outcomes and the independent predictors of those outcomes at a population level.
  
  
  RESULTS
  Population-based longitudinal study including all prevalent HF cases in Catalonia (Spain) on December 31st, 2012. Patients were divided in 3 groups: patients without a previous HF hospitalization, patients with a remote (>1 year) HF hospitalization and patients with a recent (<1 year) HF admission. We analyzed 1year all-cause and HF hospitalizations, and all-cause mortality. Logistic regression was used to identify the independent predictors of each of those outcomes. A total of 88,195 patients were included. Mean age was 77 years, 55% were women. Comorbidities were frequent. Fourteen percent of patients had never been hospitalized, 71% had a remote HF hospitalization and 15% a recent hospitalization. At 1-year follow-up, all-cause and HF hospitalization were 53% and 8.8%, respectively. One-year all-cause mortality rate was 14%, and was higher in patients with a recent HF hospitalization (24%). The presence of diabetes mellitus, atrial fibrillation or chronic kidney disease was independently associated with all-cause and HF hospitalization and all-cause mortality. Hospital admissions and emergency department visits the previous year were also found to be independently associated with the three study outcomes.
  
  
  CONCLUSIONS
  Outcomes are different depending on the HF population studied. Some comorbidity, an all-cause hospitalization or emergency department visit the previous year were associated with a worse outcome.
authors.affiliation: Heart Failure Programme, Department of Cardiology, Hospital del Mar, Barcelona, Spain.|Heart Diseases Biomedical Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Núria
authors.identifier: http://orcid.org/0000-0003-3110-6572
authors.initials: N
authors.lastname: Farré
authors.affiliation: Analysis on Demand and Activity Division, Catalan Health Service, Barcelona, Spain.
authors.forename: Emili
authors.initials: E
authors.lastname: Vela
authors.affiliation: Analysis on Demand and Activity Division, Catalan Health Service, Barcelona, Spain.
authors.forename: Montse
authors.initials: M
authors.lastname: Clèries
authors.affiliation: Analysis on Demand and Activity Division, Catalan Health Service, Barcelona, Spain.
authors.forename: Montse
authors.initials: M
authors.lastname: Bustins
authors.affiliation: Ciccarone Center for the Prevention of Heart Disease, Department of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America.|Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America.
authors.forename: Miguel
authors.initials: M
authors.lastname: Cainzos-Achirica
authors.affiliation: Heart Failure Programme, Department of Cardiology, Hospital del Mar, Barcelona, Spain.|Heart Diseases Biomedical Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Enjuanes
authors.affiliation: Heart Failure Programme, Department of Cardiology, Hospital del Mar, Barcelona, Spain.|Heart Diseases Biomedical Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Moliner
authors.affiliation: Heart Failure Programme, Department of Cardiology, Hospital del Mar, Barcelona, Spain.|Heart Diseases Biomedical Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Ruiz
authors.affiliation: Heart Diseases Biomedical Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.|Jordi Gol Primary Care Research Institute, Catalan Institute of Heath, Barcelona, Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Verdú-Rotellar
authors.affiliation: Heart Diseases Biomedical Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Heart Failure Program, Cardiology Department, University Hospital Bellvitge, Hospitalet de Llobregat, Barcelona, Spain.|School of Medicine, Department of Clinical Science, University of Barcelona, Hospitalet de Llobregat, Barcelona, Spain.|IDIBELL (Bellvitge Biomedical Research Institute), Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Comín-Colet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000503:physiopathology; D004635:Emergency Medicine; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000453:epidemiology* / Q000503:physiopathology; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000503:physiopathology; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology / Q000503:physiopathology; D013030:Spain / Q000453:epidemiology