title: Prophylactic Measures During Induction for Acute Myeloid Leukemia.
abstract: OBJECTIVE
  Improved management of infectious complications of acute myeloid leukemia (AML) has contributed substantially to the success of care over the past half century. An important approach to reducing infectious complications during the induction period of chemotherapy involves the use of prophylactic antibacterial, antiviral, and antifungal agents targeting likely pathogens.
  
  
  RESULTS
  There is not a one-size-fits-all approach to prophylaxis; every patient undergoing induction therapy should be evaluated individually and within the context of local microbiologic epidemiology and host risk factors. Pharmacologic and non-pharmacologic interventions as well as novel diagnostic platforms can help mitigate the risk of life-threatening infection in patients with AML who undergo induction chemotherapy.
authors.affiliation: Division of General Internal Medicine, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 East 68th Street, Box 331, New York, NY, 10065, USA. mwm9004@med.cornell.edu.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: McCarthy
authors.affiliation: Transplantation-Oncology Infectious Diseases Program, Medical Mycology Research Laboratory, Weill Cornell Medical Center, New York, NY, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D006801:Humans; D007239:Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology / Q000821:virology; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology / Q000821:virology; D012307:Risk Factors; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000998:Antiviral Agents; D014230:Triazoles
keywords: Carbapenemase; Fluoroquinolone prophylaxis; Induction chemotherapy; Isavuconazole; Posaconazole; T2 magnetic resonance