title: Pharmacogenetics-based personalized therapy: Levels of evidence and recommendations from the French Network of Pharmacogenetics (RNPGx).
abstract: More than 50 laboratories offer pharmacogenetic testing in France. These tests are restricted to a limited number of indications: prevention of serious adverse drug reactions; choice of most appropriate therapeutic option; dose adjustment for a specific drug. A very small proportion of these tests are mentioned in drug information labeling and the data provided (if any) are generally insufficient to ascertain whether a test is required and if it is useful. This article discusses the rationale for evaluating the performance and clinical usefulness of pharmacogenetics and provides, on behalf of the French national network of pharmacogenetics (RNPGx), three levels of recommendation for testing: essential, advisable, and possibly helpful.
authors.affiliation: Service de pharmacologie, toxicologie et pharmacovigilance, centre de biologie et de recherche en santé, CHU de Limoges, 2, avenue Martin-Luther-King, 87042 Limoges, France. Electronic address: nicolas.picard@unilim.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Picard
authors.affiliation: Unité de toxicologie et plateforme de génétique moléculaire des cancers, laboratoire de biochimie, CHU Carémeau, 30900 Nîmes, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Boyer
authors.affiliation: Laboratoire d'oncopharmacologie, centre Antoine-Lacassagne, 06189 Nice, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Etienne-Grimaldi
authors.affiliation: Laboratoire de biochimie et biologie moléculaire, CHU Bretonneau, 37044 Tours, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Barin-Le Guellec
authors.affiliation: Institut universitaire du cancer Toulouse, Oncopole, laboratoire de biologie médicale oncologique, secteur pharmacologie, 31059 Toulouse, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Thomas
authors.affiliation: Laboratoire de biochimie, pharmacogénétique et oncologie moléculaire, hôpital européen Georges-Pompidou, 75908 Paris, France.
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Loriot
mesh_terms: D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics / Q000517:prevention & control*; D060005:Genotyping Techniques; D006801:Humans; D010597:Pharmacogenetics; D000071185:Pharmacogenomic Testing; D057285:Precision Medicine
chemical_list: D019389:Cytochrome P-450 CYP2D6
keywords: Clinical biology; Level of evidence; Recommendations