title: Oral administration ofClostridium butyricumCGMCC0313-1 inhibits β-lactoglobulin-induced intestinal anaphylaxis in a mouse model of food allergy.
abstract: BACKGROUND
  Probiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear. There has been a growing interest in the use of beneficial bacteria for allergic diseases recently. This study aimed at exploring whetherClostridium butyricumCGMCC0313-1 (C. butyricum) can reduce β-lactoglobulin(BLG)-induced intestinal anaphylaxis in a murine model of food allergy.
  
  
  METHODS
  The preventive and therapeutic effects of oralC. butyricumon anaphylactic symptoms induced via BLG in food allergy mice were investigated. Intestinal anaphylaxis, T helper (Th)-specific cytokines and transcription factors, secretory IgA (sIgA), CD4+ CD25+ Foxp3Treg cell and histopathological alterations were examined.
  
  
  RESULTS
  Clostridium butyricumsignificantly ameliorated intestinal anaphylaxis symptoms in the food allergy mice. sIgA and CD4+ CD25+ Foxp3Treg cell were increased by oralC. butyricum. It also reversed the imbalance of Th1/Th2 andTh17/Treg.
  
  
  CONCLUSIONS
  Clostridium butyricumreduces BLG-induced intestinal anaphylaxis in mice and might be an additional or supplementary therapy for food allergy.
authors.affiliation: Department of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, 710032 China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Geratology, Xijing Hospital, the Fourth Military Medical University, Xi'an, 710032 China.
authors.forename: Hui
authors.initials: H
authors.lastname: Su
authors.affiliation: Department of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, 710032 China.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, 710032 China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Wu
authors.affiliation: Respiratory Department, Shenzhen Children's Hospital, Shenzhen, 518036 China.
authors.forename: Mengyun
authors.initials: M
authors.lastname: Liu
authors.affiliation: Respiratory Department, Shenzhen Children's Hospital, Shenzhen, 518036 China.
authors.forename: Jianqiong
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, 710032 China.
authors.forename: Minghua
authors.initials: M
authors.lastname: Zeng
authors.affiliation: Respiratory Department, Shenzhen Children's Hospital, Shenzhen, 518036 China.
authors.forename: Yuejie
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, 710032 China.
authors.forename: Xin
authors.initials: X
authors.lastname: Sun
keywords: Clostridium butyricum; Food allergy; Mice; Probiotics; β-Lactoglobulin