title: Elevated Mean Airway Pressure and Central Venous Pressure in the First Day of Mechanical Ventilation Indicated Poor Outcome.
abstract: OBJECTIVE
  The relationship between respiratory mechanical parameters and hemodynamic variables remains unclear. This study was performed to determine whether mean airway pressure and central venous pressure in the first day of mechanical ventilation are associated with patient outcomes.
  
  
  METHODS
  Retrospective first 24-hour comparison during ICU stay.
  
  
  METHODS
  The Department of Critical Care Medicine of Peking Union Medical College Hospital.
  
  
  METHODS
  Patients with mechanical ventilation.
  
  
  METHODS
  None.
  
  
  RESULTS
  The clinical data of patients who received mechanical ventilation, especially respiratory and hemodynamic data, were collected and analyzed. In terms of the hemodynamic and perfusion data, the nonsurvivors group (177/2,208) had higher heart rate, respiratory rate, central venous pressure, and lactates and a lower perfusion index and P(v-a)CO2 (p < 0.05). In terms of respiratory condition, mean airway pressure, peak airway pressure, positive end-expiratory pressure, driving pressure, and inspiratory time/total respiration time of nonsurvivors were significantly higher, and arterial oxygen pressure and dynamic compliance worsened and were lower than the survivors (p < 0.05). Increased central venous pressure (odds ratio, 1.125; 95% CI, 1.069-1.184; p < 0.001) and elevated mean airway pressure (odds ratio, 1.125; 95% CI, 1.069-1.184; p < 0.001) were independently associated with 28-day mortality. The area under receiver operating characteristic demonstrated that central venous pressure and mean airway pressure were measured at 0.795 (95% CI, 0.654-0.757) and 0.833 (95% CI, 0.608-0.699), respectively. Based on the cutoff of central venous pressure and mean airway pressure, all of the participants were divided into the following groups: low central venous pressure and mean airway pressure, only high central venous pressure or mean airway pressure, or high central venous pressure and mean airway pressure. Post hoc tests showed significant differences among these three groups based on 28-day survival (log rank [Mantel-Cox], 131.931; p < 0.001).
  
  
  CONCLUSIONS
  During the first 24 hours of mechanical ventilation, patients with elevated mean airway pressure and elevated central venous pressure had worse outcomes.
authors.affiliation: All authors: Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Long
authors.forename: Longxiang
authors.initials: L
authors.lastname: Su
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Na
authors.initials: N
authors.lastname: Cui
authors.forename: Wenzhao
authors.initials: W
authors.lastname: Chai
authors.forename: Xiaoting
authors.initials: X
authors.lastname: Wang
authors.forename: Xi
authors.initials: X
authors.lastname: Rui
authors.forename: Dawei
authors.initials: D
authors.lastname: Liu
mesh_terms: D000368:Aged; D002496:Central Venous Pressure / Q000502:physiology*; D003422:Critical Care / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial / Q000401:mortality*; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics; D012189:Retrospective Studies
chemical_list: D007773:Lactates