title: [Polymorphism of Glutathione S-Transferases and Genetic Sensitivity of Childhood Acute Lymphoblastic Leukemia: A Meta-Analysis].
abstract: OBJECTIVE
  To analyze the relationship between GST polymorphism and childhood acute lymphoblastic leukemia(ALL) risk.
  
  
  METHODS
  The relevant references of this relationship in English or Chinese were extensively searched through PubMed, Embase, China National Knowledge Internet(CNKI) and Wanfang Database up to August 2015 based on the inclusion and exclusion criteria. GST polymorphism-specific odd ratios(OR) with corresponding 95% confidence intervals(CI) were calculated with the STATA statistical package. Heterogeneity across studies was assessed, and funnel plots were constructed to test the publication bias.
  
  
  RESULTS
  A total of 27 studies concerning the GST polymorphisms and the risk of ALL were evaluated, which included 3736 cases of childhood acute lymphoblastic leukemia and 5549 controls. Significant summary OR of ALL were obtained for GSTM1 (OR=1.41, 95% CI=1.21-1.65) and GSTT1 (OR=1.26, 95% CI=1.05-1.50). Subgroup analysis showed that GSTM1 variant was associated with increased susceptibility to ALL in group of Blacks, Asians, PB (Population-based controls), HB (Hospital-based controls) '≥ 100 cases' and '< 100 cases'. Regarding GSTT1 polymorphism, significant relation with ALL risk was found in subgroup of Asians, PB and '≥ 100 cases'.
  
  
  CONCLUSIONS
  The GSTM1 and GSTT1 polymorphisms may be cerrelated with an increased risk of ALL. Further investigations are needed to confirm the conclusions.
authors.affiliation: Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China. E-mail: baihai98@tom.com.
authors.forename: Hai
authors.initials: H
authors.lastname: Bai
mesh_terms: D002675:Child, Preschool; D002681:China; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase