title: Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study.
abstract: BACKGROUND
  Kidney disease improving global outcomes provided a new classification for chronic kidney disease (CKD) by subdividing the G3 stage into G3a and G3b stages based on glomerular filtration rate (GFR) in 2012. Currently, a few methods are used to evaluate GFR, including measured GFR (mGFR) and estimated GFR (eGFR). One of the mGFR was99mTc-DTPA scintigraphy method and eGFR using GFR equations were used clinically. Equations were modification of diet in renal disease (MDRD), chronic kidney disease epidemiology collaboration (CKD-EPI), and Chinese adapted MDRD (C-MDRD). This study assessed the accuracy of three different equations for estimated glomerular filtration rate (eGFR) with mGFR using DTPA scintigraphy method as the standard in a population of Chinese chronic kidney disease patients at the G3a stage.
  
  
  RESULTS
  One hundred and twenty-two patients (age 52.0 ± 15.6 years, 69 were male) were determined as CKD stage 3 based on mGFR. Patients were divided into G3a (47 patients) and G3b (75 patients) subgroups. Bias between eGFR for CKD-EPI and reference mGFR was 0.92 mL/min and 95% limits of agreement was -38.82 to 40.67 mL/min. Bias between eGFR for C-MDRD and mGFR was 3.76 and 95% limits of agreement was -39.32 to 46.85 mL/min. Bias between eGFR for MDRD and mGFR was 3.53 and 95% limits of agreement was -43.35 to 50.4 mL/min. The CKD-EPI equation showed better diagnostic value with a greater area under the receiver operating characteristic curve (AUC: 0.763). AUC for MDRD and C-MDRD were 0.75 and 0.757, respectively.
  
  
  CONCLUSIONS
  There were no obvious advantages in accuracy, sensitivity, and specificity for the diagnosis of patients at the G3a stage using the CKD-EPI equation.
authors.affiliation: The Nephrology Center of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.|Zhengzhou University Institute of Nephrology, Zhengzhou, China.
authors.forename: Yanna
authors.initials: Y
authors.lastname: Dou
authors.affiliation: The Nephrology Center of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.|Zhengzhou University Institute of Nephrology, Zhengzhou, China.
authors.forename: Xiran
authors.initials: X
authors.lastname: Sun
authors.affiliation: The Nephrology Center of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.|Zhengzhou University Institute of Nephrology, Zhengzhou, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: The Nephrology Center of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.|Zhengzhou University Institute of Nephrology, Zhengzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: The Nephrology Center of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.|Zhengzhou University Institute of Nephrology, Zhengzhou, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xiao
authors.affiliation: The Nephrology Center of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.|Zhengzhou University Institute of Nephrology, Zhengzhou, China.
authors.forename: Genyang
authors.initials: G
authors.lastname: Cheng
authors.affiliation: The Nephrology Center of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.|Zhengzhou University Institute of Nephrology, Zhengzhou, China.|Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Keele, ST5 5BG, UK.
authors.forename: Dahai
authors.initials: D
authors.lastname: Yu
authors.affiliation: The Nephrology Center of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. zhanzhengzhao@zzu.edu.cn.|Zhengzhou University Institute of Nephrology, Zhengzhou, China. zhanzhengzhao@zzu.edu.cn.
authors.forename: Zhanzheng
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis*; D012720:Severity of Illness Index
keywords: Accuracy; Chronic kidney disease; G3a stage; Glomerular filtration rate equations