title: Triple-reassortant influenza A virus with H3 of human seasonal origin, NA of swine origin, and internal A(H1N1) pandemic 2009 genes is established in Danish pigs.
abstract: This report describes a triple-reassortant influenza A virus with a HA that resembles H3 of human seasonal influenza from 2004 to 2005, N2 from influenza A virus already established in swine, and the internal gene cassette from A(H1N1)pdm09 has spread in Danish pig herds. The virus has been detected in several Danish pig herds during the last 2-3 years and may possess a challenge for human as well as animal health.
authors.affiliation: National Veterinary Institute, Technical University of Denmark, Frederiksberg C, Denmark.
authors.forename: Jesper Schak
authors.identifier: 0000-0002-1727-9904
authors.initials: JS
authors.lastname: Krog
authors.affiliation: National Veterinary Institute, Technical University of Denmark, Frederiksberg C, Denmark.
authors.forename: Charlotte Kristiane
authors.initials: CK
authors.lastname: Hjulsager
authors.affiliation: Merial Norden A/S, Hørsholm, Denmark.
authors.forename: Michael Albin
authors.initials: MA
authors.lastname: Larsen
authors.affiliation: National Veterinary Institute, Technical University of Denmark, Frederiksberg C, Denmark.
authors.forename: Lars Erik
authors.initials: LE
authors.lastname: Larsen
mesh_terms: D000818:Animals; D003718:Denmark; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D009980:Influenza A virus / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D007251:Influenza, Human / Q000821:virology*; D009439:Neuraminidase / Q000235:genetics* / Q000378:metabolism; D009976:Orthomyxoviridae Infections / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D016865:Reassortant Viruses / Q000145:classification / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D011995:Recombination, Genetic; D012621:Seasons; D013552:Swine; D013553:Swine Diseases / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; D014764:Viral Proteins; C487630:NA protein, influenza A virus; D009439:Neuraminidase
keywords: H1N1pdm09; H3N2; case report; influenza A virus; zoonosis