title: Prevalence of polycystic ovary syndrome in Chinese obese women of reproductive age with or without metabolic syndrome.
abstract: OBJECTIVE
  To compare the prevalence of polycystic ovary syndrome (PCOS) and related clinical characteristics between metabolically unhealthy obese (MUO) and metabolically healthy obese (MHO) women of reproductive age.
  
  
  METHODS
  Cross-sectional clinical study.
  
  
  METHODS
  Tertiary hospital.
  
  
  METHODS
  We studied 299 MUO and 122 MHO Chinese women matched on body mass index. Metabolically healthy obese was defined as obesity with no more than one metabolic abnormality. Diagnosis of PCOS was based on the revised Rotterdam criteria.
  
  
  METHODS
  Each subject underwent physical examination, laboratory evaluation, and gynecologic ultrasound for a diagnosis of PCOS or metabolic syndrome (MetS).
  
  
  METHODS
  Prevalence of PCOS was calculated in both groups. Insulin resistance was determined by homeostasis model assessment of insulin resistance or by the insulin sensitivity index derived from Bergman's minimal model. Fat distribution was measured with computerized tomography scan.
  
  
  RESULTS
  Prevalence of PCOS and its components did not differ between MUO and BMI-matched MHO groups (67.89% and 66.96%, respectively). In logistic regression analysis, MetS did not predict the presence of PCOS after adjusting for confounding factors. The MHO group had lower visceral adipose tissue, relatively higher insulin sensitivity, and better β-cell function, compared with those in the MUO group; but there were no significant differences in sex hormones (except for free T and sex hormone-binding globulin) and ultrasound manifestations between MHO and MUO women.
  
  
  CONCLUSIONS
  For the first time, our findings suggest that MetS does not add additional risk for PCOS. In addition, we found that both MUO and MHO are associated with insulin resistance to some extent.
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Peiwen
authors.initials: P
authors.lastname: Liang
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Liuqing
authors.initials: L
authors.lastname: Xi
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Shi
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Wanyu
authors.initials: W
authors.lastname: Li
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Shaoqian
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Yingkai
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Gu
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Weiqiong
authors.initials: W
authors.lastname: Gu
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Wang
authors.affiliation: Shanghai Clinical Center for Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China. Electronic address: hongjie@medmail.com.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Hong
mesh_terms: D050154:Adiposity; D000328:Adult; D000367:Age Factors; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D000067329:Obesity, Metabolically Benign / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D060728:Reproductive Health; D012307:Risk Factors; D062606:Tertiary Care Centers; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Metabolically healthy obese; metabolic syndrome; polycystic ovary syndrome