title: [Contemporary markers and histological features of prostate cancer].
abstract: Increasing prostate cancer incidence rates highlight the importance of more timely diagnosis with the ultimate aim of reducing cancer-specific mortality, while maintaining patients quality of life. Until recently, digital rectal examination and prostate-specific antigen have been used for diagnosis of prostate cancer. Recent advances in medical technologies and laboratory testing have led to introducing new cancer markers into clinical practice. The most highly demanded of them are the PCA-3, -2proPSA and Prostate Health Index. Despite the wide range of laboratory tests, a prostate biopsy with a subsequent morphological examination of biopsy tissue specimens remains the only way to definitively diagnose prostate cancer.
authors.affiliation: Department of Urology, A.I. Evdokimov Moscow State University of Medicine and Dentistry of Minzdrav of Russia, Moscow.
authors.forename: A O
authors.initials: AO
authors.lastname: Vasilyev
authors.affiliation: Department of Urology, A.I. Evdokimov Moscow State University of Medicine and Dentistry of Minzdrav of Russia, Moscow.
authors.forename: E A
authors.initials: EA
authors.lastname: Prilepskaya
authors.affiliation: Department of Urology, A.I. Evdokimov Moscow State University of Medicine and Dentistry of Minzdrav of Russia, Moscow.
authors.forename: M V
authors.initials: MV
authors.lastname: Kovylina
authors.affiliation: Department of Urology, A.I. Evdokimov Moscow State University of Medicine and Dentistry of Minzdrav of Russia, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Govorov
authors.affiliation: Department of Urology, A.I. Evdokimov Moscow State University of Medicine and Dentistry of Minzdrav of Russia, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Sadchenko
authors.affiliation: Department of Urology, A.I. Evdokimov Moscow State University of Medicine and Dentistry of Minzdrav of Russia, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Sidorenkov
authors.affiliation: Department of Urology, A.I. Evdokimov Moscow State University of Medicine and Dentistry of Minzdrav of Russia, Moscow.
authors.forename: D Yu
authors.initials: DY
authors.lastname: Pushkar
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics / Q000652:urine*; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood / Q000652:urine; D001706:Biopsy; D005819:Genetic Markers; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000235:genetics / Q000473:pathology* / Q000652:urine
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D005819:Genetic Markers; C479341:prostate cancer antigen 3, human; D017430:Prostate-Specific Antigen
keywords: a biopsy of the prostate; diagnosis; pathological examination; prostate cancer; prostate specific antigen