title: Role of Cdc6 During Oogenesis and Early Embryo Development in Mouse and Xenopus laevis.
abstract: Cdc6 is an important player in cell cycle regulation. It is involved in the regulation of both S-phase and M-phase. Its role during oogenesis is crucial for repression of the S-phase between the first and the second meiotic M-phases, and it also regulates, via CDK1 inhibition, the M-phase entry and exit. This is of special importance for the reactivation of the major M-phase-regulating kinase CDK1 (Cyclin-Dependent Kinase 1) in oocytes entering metaphase II of meiosis and in embryo cleavage divisions, in which precise timing allows coordination between cell cycle events and developmental program of the embryo. In this chapter, we discuss the role of Cdc6 protein in oocytes and early embryos.
authors.affiliation: Faculty of Biology, Institute of Zoology, Department of Embryology, University of Warsaw, Warsaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Borsuk
authors.affiliation: Faculty of Biology, Institute of Zoology, Department of Embryology, University of Warsaw, Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Jachowicz
authors.affiliation: The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Kloc
authors.affiliation: CNRS UMR6092, Cell Cycle Team, Rennes, France.|Université Rennes 1, Institut de Génétique et Développement de Rennes (IGDR), Rennes, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Tassan
authors.affiliation: CNRS UMR6092, Cell Cycle Team, Rennes, France. jacek.kubiak@univ-rennes1.fr.|Université Rennes 1, Institut de Génétique et Développement de Rennes (IGDR), Rennes, France. jacek.kubiak@univ-rennes1.fr.|Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland. jacek.kubiak@univ-rennes1.fr.
authors.forename: Jacek Z
authors.initials: JZ
authors.lastname: Kubiak
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D051379:Mice; D009687:Nuclear Proteins / Q000378:metabolism*; D009865:Oocytes / Q000378:metabolism*; D009866:Oogenesis / Q000502:physiology*; D029867:Xenopus Proteins / Q000378:metabolism; D014982:Xenopus laevis
chemical_list: C502132:CDC6 protein, mouse; D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D029867:Xenopus Proteins