title: DWI as an Imaging Biomarker for Bladder Cancer.
abstract: OBJECTIVE
  DWI has been increasingly applied in the management of bladder cancer. In this article, we discuss the role of DWI as an imaging biomarker for bladder cancer.
  
  
  CONCLUSIONS
  The DWI signal is derived from the motion of water molecules, which represents the physiologic characteristics of the tissue of interest. The emerging evidence highlights the utility of DWI for bladder cancer detection and characterization. DWI is a potentially useful tool to individualize treatment strategies.
authors.affiliation: 1 Department of Urology, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Yoshida
authors.affiliation: 2 Department of Biomedical Engineering, Tokai University School of Engineering, Kanagawa, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Takahara
authors.affiliation: 3 Department of Radiology, UMC Groningen, Groningen, The Netherlands.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Kwee
authors.affiliation: 1 Department of Urology, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
authors.forename: Yuma
authors.initials: Y
authors.lastname: Waseda
authors.affiliation: 4 Department of Urology, Tama-Nambu Chiiki Hospital, Tokyo, Japan.
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Kobayashi
authors.affiliation: 1 Department of Urology, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Fujii
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D038524:Diffusion Magnetic Resonance Imaging; D019317:Evidence-Based Medicine; D006801:Humans; D007089:Image Enhancement; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*
chemical_list: D015415:Biomarkers
keywords: DWI; MRI; biomarker; urinary bladder neoplasms