title: Pd/Cu cooperative catalysis: an efficient synthesis of (3-isoindazolyl)allenes via cross-coupling of 2-alkynyl azobenzenes and terminal alkynes.
abstract: An efficient synthesis of (3-isoindazolyl)allenes from 2-alkynyl azobenzenes and terminal alkynes via cooperative Pd(PPh3)2Cl2/CuI-catalyzed cross-coupling has been developed. By making use of this approach, (3-isoindazolyl)allenes with various substituents can be synthesized in good to excellent yields. A rapid synthesis of biologically active indazolo[2,3-a]quinoline was also achieved using this method as the key step.
authors.affiliation: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211800, P. R. China. iamcfeng@njtech.edu.cn.
authors.forename: Chuan
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211800, P. R. China. iamcfeng@njtech.edu.cn.
authors.forename: Chao
authors.identifier: http://orcid.org/0000-0003-4494-6845
authors.initials: C
authors.lastname: Feng
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore. yamane@ntu.edu.sg.
authors.forename: Motoki
authors.initials: M
authors.lastname: Yamane