title: A game of musical chairs: Pro- and anti-resection factors compete for TOPBP1 binding after DNA damage.
abstract: DNA double strand breaks (DSBs) are generally repaired through nonhomologous end joining or homologous recombination. In this issue, Liu et al. (2017.J. Cell Biol.https://doi.org/10.1083/jcb.201607031) report that the conserved scaffold protein TOPBP1Dpb11provides binding sites for both pro- and anti-resection factors at DSBs, providing insights into repair pathway regulation.
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland kenji.shimada@fmi.ch.
authors.forename: Kenji
authors.identifier: 0000-0002-6670-3118
authors.initials: K
authors.lastname: Shimada
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.|Faculty of Natural Sciences, University of Basel, 4056 Basel, Switzerland.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Gasser
mesh_terms: D053903:DNA Breaks, Double-Stranded; D004249:DNA Damage / Q000235:genetics*; D059766:DNA End-Joining Repair / Q000235:genetics; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism*; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins