title: [Oncogenetic factors of some herpesvirus infection agents].
abstract: Currently, debate continues about the etiological role of pathogens, in particular viruses, in the development of bladder tumors, their impact on the rate of recurrence and invasive and metastatic forms. The literature has reported some evidence for oncomodulating effect of cytomegalovirus in glioblastomas and bowel tumors. There is the possible role of herpes simplex virus (HSV) type 2 as carcinogenesis cofactor that initiates the development of dysplasia and maintains it in a stable condition. Epstein - Barr virus (EBV) from a family of the oncogenic DNA viruses is associated with an increasing range of cancers. EBV has been proven to have a role in the development of Burkitts lymphoma, nasopharyngeal carcinoma and gastric cancer. The review outlines the current knowledge on the factors of oncogenesis and the role of some herpesviruses in the etiology of bladder cancer.
authors.affiliation: Department of Urology, CCH 68.
authors.forename: I V
authors.initials: IV
authors.lastname: Kosova
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral; D005260:Female; D006564:Herpesviridae / Q000378:metabolism*; D006566:Herpesviridae Infections / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000821:virology; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D014412:Tumor Virus Infections / Q000378:metabolism / Q000473:pathology
chemical_list: D009856:Oncogene Proteins, Viral
keywords: Epstein-Bar virus; bladder cancer; cytomegalovirus; herpes simplex virus type 1 and 2