title: Prospective evaluation of respiratory health benefits from reduced exposure to airborne particulate matter.
abstract: We aimed to investigate if short-term exposure to reduced particulate matter (PM) air pollution would affect respiratory function in healthy adults. We followed a cohort of 42 healthy participants from a community afflicted with severe PM air pollution to a substantially less polluted area for nine days. We measured daily airborne PM [with an aerodynamic diameter of less than 2.5 μm (PM2.5) and 10 μm (PM10)] and PM2.5carbon component concentrations. Five repeated respiratory function measurements and fractional exhaled nitric oxide test were made for each participant. Associations between respiratory health and PM exposure were assessed using linear mixed models. Each 10 μg/m3decrease in same-day PM2.5was associated with small but consistent increase in the forced expiratory volume in 1 s (FEV1) (9.00 mL) and forced vital capacity (14.35 mL). Our observations indicate that respiratory health benefits can be achieved even after a short-term reduction of exposure to PM. Our results provide strong evidence for more rigorous air pollution controls for the health benefit of populations.
authors.affiliation: a Department of Occupational and Environmental Health, School of Public Health , Fudan University , Shanghai , China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Hao
authors.affiliation: a Department of Occupational and Environmental Health, School of Public Health , Fudan University , Shanghai , China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Zhang
authors.affiliation: b State Key Laboratory of Environmental Criteria and Risk Assessment , Chinese Research Academy of Environmental Sciences , Beijing , China.
authors.forename: Bin
authors.initials: B
authors.lastname: Han
authors.affiliation: a Department of Occupational and Environmental Health, School of Public Health , Fudan University , Shanghai , China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Xu
authors.affiliation: a Department of Occupational and Environmental Health, School of Public Health , Fudan University , Shanghai , China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Feng
authors.affiliation: a Department of Occupational and Environmental Health, School of Public Health , Fudan University , Shanghai , China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.affiliation: c Department of Epidemiology and Biostatistics , College of Public Health, University of South Florida , Tampa , FL , USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: a Department of Occupational and Environmental Health, School of Public Health , Fudan University , Shanghai , China.
authors.forename: Haidong
authors.initials: H
authors.lastname: Kan
authors.affiliation: b State Key Laboratory of Environmental Criteria and Risk Assessment , Chinese Research Academy of Environmental Sciences , Beijing , China.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Bai
authors.affiliation: c Department of Epidemiology and Biostatistics , College of Public Health, University of South Florida , Tampa , FL , USA.
authors.forename: Yiliang
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: d Department of Environmental Toxicology , Preventive Medicine and MPH Education Center, Shantou University Medical College , Shantou , China.
authors.forename: William
authors.initials: W
authors.lastname: Au
authors.affiliation: a Department of Occupational and Environmental Health, School of Public Health , Fudan University , Shanghai , China.
authors.forename: Zhao-Lin
authors.initials: ZL
authors.lastname: Xia
mesh_terms: D000393:Air Pollutants / Q000032:analysis* / Q000633:toxicity*; D000397:Air Pollution / Q000517:prevention & control*; D002681:China; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D052638:Particulate Matter / Q000032:analysis*; D011446:Prospective Studies; D012129:Respiratory Function Tests; D012143:Respiratory Physiological Phenomena / Q000187:drug effects*
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter
keywords: Reduced air pollution; fractional exhaled nitric oxide; lung function; prospective study; respiratory health