title: A Woman in Her 40s With Headache and New-Onset Seizures.
abstract: A woman in her 40s with a history of plasma cell leukemia presented with 1 month of intermittent headaches followed by a seizure. Results from laboratory studies were notable for a cerebrospinal fluid opening pressure of 28 mm H2O and 8 white blood cells, including 1 atypical plasma cell. Imaging studies revealed confluent bifrontal white matter fluid-attenuated inversion recovery hyperintensities, as well as a contrast-enhancing sellar lesion. The patient underwent a stereotactic biopsy. The differential diagnosis, pathologic findings, and diagnosis are discussed.
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Maya S
authors.initials: MS
authors.lastname: Graham
authors.affiliation: Department of Hematology, Boston Medical Center, Boston, Massachusetts.
authors.forename: Anita
authors.initials: A
authors.lastname: Pudusseri
authors.affiliation: Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Helgager
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Derek P
authors.initials: DP
authors.lastname: Narendra
authors.affiliation: Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Umberto
authors.initials: U
authors.lastname: De Girolami
authors.affiliation: Department of Pathology, Division of Hematopathology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Geraldine S
authors.initials: GS
authors.lastname: Pinkus
authors.affiliation: Department of Hematology, Boston Medical Center, Boston, Massachusetts.
authors.forename: Vaishali
authors.initials: V
authors.lastname: Sanchorawala
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Edison
authors.initials: E
authors.lastname: Miyawaki
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006261:Headache / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000150:complications*; D008279:Magnetic Resonance Imaging; D012640:Seizures / Q000000981:diagnostic imaging / Q000209:etiology*