title: Effects of 3% trehalose as an adjuvant treatment after LASIK.
abstract: OBJECTIVE
  To evaluate the effect of 3% trehalose as an adjuvant in the standard treatment after laser-assisted in situ keratomileusis.
  
  
  METHODS
  Interventional prospective comparative single-blind study.
  
  
  METHODS
  Department of Ophthalmology, Hospital Quirón Zaragoza, Spain.
  
  
  METHODS
  A total of 26 eyes (13 patients) were included, of which 12 eyes (group 1) received conventional treatment with lubricant drops of hyaluronic acid (0.15%) and 14 eyes (group 2) received, additionally, an ophthalmic solution of 3% trehalose. Pre- and postoperative quality-of-life tests and vital stains, tear breakup time, and osmolarity measurements were made.
  
  
  RESULTS
  We obtained statistically significant differences between the groups in the Symptom Assessment in Dry Eye test in all visits with respect to severity, and in the postoperative day 1 visit with respect to frequency, in all cases favoring the trehalose treatment. The values of osmolarity were not significantly different between groups. However, we did find significant differences in the Oxford scale in day 90 for the trehalose treatment (P<0.001), and in the National Eye Institute scale in day 30 (P=0.02).
  
  
  CONCLUSIONS
  The results of this exploratory study indicate that the adjuvant treatment with 3% trehalose could be superior with respect to the standard treatment, with improvements in the objective and subjective parameters of tear quality.
authors.affiliation: Department of Ophthalmology, Hospital Quirón; Department of Ophthalmology, Hospital Universitario Miguel Servet; Instituto de Investigación Sanitaria de Aragón (IIS).
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Mateo Orobia
authors.affiliation: Department of Ophthalmology, Hospital Quirón; Department of Ophthalmology, Hospital Clínico Universitario Lozano-Blesa.
authors.forename: Paula
authors.initials: P
authors.lastname: Casas Pascual
authors.affiliation: Department of Ophthalmology, Hospital Quirón.
authors.forename: José Á
authors.initials: JÁ
authors.lastname: Cristóbal Bescós
authors.affiliation: Department of Ophthalmology, Hospital Quirón; Department of Ophthalmology, Hospital Clínico Universitario Lozano-Blesa.
authors.forename: Diana
authors.initials: D
authors.lastname: Perez García
authors.affiliation: Department of Ophthalmology, Hospital Quirón; Department of Ophthalmology, Hospital Clínico Universitario Lozano-Blesa.
authors.forename: Carlos
authors.initials: C
authors.lastname: Peiro Embid
authors.affiliation: Department of Ophthalmology, Hospital Quirón; Department of Ophthalmology, Hospital Clínico Universitario Lozano-Blesa.
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Del Buey Sayas
authors.affiliation: Department of Ophthalmology, Hospital Quirón.
authors.forename: Valentyna
authors.initials: V
authors.lastname: Korobko Kulikova
authors.affiliation: Department of Anesthesiology, Hospital Universitario Miguel Servet, Zaragoza, Spain.
authors.forename: Noelia
authors.initials: N
authors.lastname: Lafuente Ojeda
keywords: LASIK; dry eye syndrome; hyaluronic acid; osmolarity; trehalose