title: The role of oxidative stress on the pathophysiology of metabolic syndrome.
abstract: Metabolic syndrome (MetS) has a high prevalence around the world. Considering the components used to classify MetS, it is clear that it is closely related to obesity. These two conditions begin with an increase in abdominal adipose tissue, which is metabolically more active, containing a greater amount of resident macrophages compared to other fat deposits. Abdominal adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving MetS components, namely insulin resistance, hypertension and hyperlipidemia. One way to block the effects of oxidative stress would be through the antioxidant defense system, which offsets the excess free radicals. It is known that individuals with metabolic syndrome and obesity have high consumption of fats and sugars originated from processed foods containing high levels of sodium as well as low intake of fruits and vegetables, thus maintaining a state of oxidative stress, that can speed up the onset of MetS. Healthy eating habits could prevent or delay MetS by adding antioxidant-rich foods into the diet.
authors.affiliation: Department of Pathology, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista "Júlio de Mesquita Filho", Botucatu, SP, Brazil.
authors.forename: Fabiane Valentini
authors.initials: FV
authors.lastname: Francisqueti
authors.affiliation: Department of Pathology, Faculdade de Medicina de Botucatu, Unesp, Botucatu, SP, Brazil.
authors.forename: Lidiana Camargo Talon
authors.initials: LC
authors.lastname: Chiaverini
authors.affiliation: Department of Pathology, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista "Júlio de Mesquita Filho", Botucatu, SP, Brazil.
authors.forename: Klinsmann Carolo Dos
authors.initials: KC
authors.lastname: Santos
authors.affiliation: Department of Chemistry and Biochemistry, Instituto de Biociências de Botucatu, Unesp, Botucatu, SP, Brazil.
authors.forename: Igor Otávio
authors.initials: IO
authors.lastname: Minatel
authors.affiliation: Department of Internal Medicine, Faculdade de Medicina de Botucatu, Unesp, Botucatu, SP, Brazil.
authors.forename: Carolina Berchieri
authors.initials: CB
authors.lastname: Ronchi
authors.affiliation: Department of Internal Medicine, Faculdade de Medicina de Botucatu, Unesp, Botucatu, SP, Brazil.
authors.forename: Artur Junio Togneri
authors.initials: AJ
authors.lastname: Ferron
authors.affiliation: Department of Internal Medicine, Faculdade de Medicina de Botucatu, Unesp, Botucatu, SP, Brazil.
authors.forename: Ana Lúcia A
authors.initials: AL
authors.lastname: Ferreira
authors.affiliation: Department of Pathology, Faculdade de Medicina de Botucatu, Unesp, Botucatu, SP, Brazil.
authors.forename: Camila Renata
authors.initials: CR
authors.lastname: Corrêa
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D005247:Feeding Behavior / Q000502:physiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000503:physiopathology*; D009765:Obesity / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D015415:Biomarkers