title: Analgesic and anti-inflammatory activities of 80% methanol root extract of Jasminum abyssinicum Hochst. ex. Dc. (Oleaceae) in mice.
abstract: BACKGROUND
  Pain and inflammation are associated with the pathophysiology of various clinical conditions. Most analgesic and anti-inflammatory drugs available in the market present a wide range of problems. The current study was aimed at investigating the analgesic and anti-inflammatory activity of 80% methanol extract of J. abyssinicum root.
  
  
  METHODS
  The analgesic activity was determined using tail-flick test and acetic acid induced writhing, whereas anti-inflammatory activity was determined by carrageenan induced paw edema and formalin induced pedal edema, carried out in vivo. The test group received three different doses of the extract (50mg/kg, 100mg/kg and 200mg/kg) orally. The positive control group received diclofenac (10mg/kg), aspirin (100mg/kg or 150mg/kg) or morphine (20mg/kg) orally. The negative control group received vehicle (2% Tween 80, 10ml/kg) orally. Furthermore, preliminary phytochemical screening was carried out.
  
  
  RESULTS
  Oral administration of J. abbysinicum 80% methanol extract (at all doses) significantly (p<0.001) inhibit pain sensation in the pain models. Similarly, the extract demonstrated anti-inflammatory effect in the inflammation models in mice. Preliminary phytochemical screening showed the presence of saponins, flavonoids, terpenoids, triterpenens and glycosides.
  
  
  CONCLUSIONS
  The data obtained from the present study indicates that the extract possessed a significant analgesic and anti-inflammatory activity, upholding the folkloric use of the plant.
authors.affiliation: Haramaya University, School of Pharmacy, College of Medical and Health Sciences, Harar P.O.Box 235, Ethiopia. Electronic address: ytadios@yahoo.com.
authors.forename: Yohannes
authors.initials: Y
authors.lastname: Tadiwos
authors.affiliation: Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O.Box 1176, Addis Ababa, Ethiopia. Electronic address: teshome.nedi@aau.edu.et.
authors.forename: Teshome
authors.initials: T
authors.lastname: Nedi
authors.affiliation: Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O.Box 1176, Addis Ababa, Ethiopia; Howard University, USA. Electronic address: ephrem.engidawork@gmail.com.
authors.forename: Ephrem
authors.initials: E
authors.lastname: Engidawork
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000517:prevention & control; D031660:Jasminum / Q000737:chemistry* / Q000633:toxicity; D008297:Male; D000432:Methanol; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry*; D012997:Solvents
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D012997:Solvents; D004008:Diclofenac; D009020:Morphine; D000432:Methanol
keywords: Analgesia; Anti-inflammatory; J. abyssinicum