title: Development and Reliability of the OMERACT Thumb Base Osteoarthritis Magnetic Resonance Imaging Scoring System.
abstract: OBJECTIVE
  To develop the Outcome Measures in Rheumatology (OMERACT) thumb base osteoarthritis (OA) magnetic resonance imaging (MRI) scoring system (TOMS) for the assessment of inflammatory and structural abnormalities in this hand OA subset, and test its cross-sectional reliability.
  
  
  METHODS
  Included features and their scaling were agreed upon by members of the OMERACT MRI Task Force using the Hand OA MRI scoring system as a template. A reliability exercise was performed in which 3 readers participated, using a preliminary atlas with examples to facilitate reading. Each reader independently scored a set of 20 MRI (coronal and axial T1- and T2-weighted fat-suppressed images, of which 5 included T1-weighted fat-suppressed post-Gadolinium images). Intra- and inter-reader reliability were assessed using ICC, percentage exact agreement (PEA), and percentage close agreement (PCA).
  
  
  RESULTS
  The TOMS assessed the first carpometacarpal (CMC-1) and scaphotrapeziotrapezoid (STT) joints for synovitis, subchondral bone defects (including erosions, cysts, and bone attrition), osteophytes, cartilage, and bone marrow lesions on a 0-3 scale (normal to severe). Subluxation was evaluated only in the CMC-1 joint (absent/present). Reliability of scoring for both joints was comparable. Interreader ICC were good for all features (0.77-0.99 and 0.74-0.96 for CMC-1 and STT joints, respectively). Intrareader reliability analyses gave similar results. PCA was ≥ 65% for all features. PEA was low to moderate, with better performance for subchondral bone defects, subluxation, and bone marrow lesions.
  
  
  CONCLUSIONS
  A thumb base OA MRI scoring system has been developed. The OMERACT TOMS demonstrated good intrareader and interreader reliability. Longitudinal studies are warranted to investigate reliability of change scores and responsiveness.
authors.affiliation: From the Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie, Paris, France; Spire Sciences Inc., Boca Raton, Florida, USA; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Departments of Radiology and Medicine, University of California San Francisco, San Francisco, California, USA; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. f.kroon.reum@lumc.nl.|F.P. Kroon, MD, Department of Rheumatology, Leiden University Medical Center; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit; V. Foltz, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; F. Gandjbakhch, MD, Practicing Rheumatologist; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; C. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; I. Eshed, MD, Associate Professor of Radiology, Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University; H.K. Genant, MD, FACR, FRCR, Professor Emeritus of Radiology, Medicine and Orthopedics, Departments of Radiology and Medicine, University of California San Francisco; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, University of Copenhagen; M. Kloppenburg, MD, PhD, Professor of Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center; I.K. Haugen, MD, PhD, Postdoctoral Researcher; Department of Rheumatology, Diakonhjemmet Hospital. f.kroon.reum@lumc.nl.
authors.forename: Féline P B
authors.initials: FPB
authors.lastname: Kroon
authors.affiliation: From the Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie, Paris, France; Spire Sciences Inc., Boca Raton, Florida, USA; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Departments of Radiology and Medicine, University of California San Francisco, San Francisco, California, USA; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.|F.P. Kroon, MD, Department of Rheumatology, Leiden University Medical Center; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit; V. Foltz, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; F. Gandjbakhch, MD, Practicing Rheumatologist; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; C. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; I. Eshed, MD, Associate Professor of Radiology, Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University; H.K. Genant, MD, FACR, FRCR, Professor Emeritus of Radiology, Medicine and Orthopedics, Departments of Radiology and Medicine, University of California San Francisco; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, University of Copenhagen; M. Kloppenburg, MD, PhD, Professor of Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center; I.K. Haugen, MD, PhD, Postdoctoral Researcher; Department of Rheumatology, Diakonhjemmet Hospital.
authors.forename: Philip G
authors.initials: PG
authors.lastname: Conaghan
authors.affiliation: From the Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie, Paris, France; Spire Sciences Inc., Boca Raton, Florida, USA; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Departments of Radiology and Medicine, University of California San Francisco, San Francisco, California, USA; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.|F.P. Kroon, MD, Department of Rheumatology, Leiden University Medical Center; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit; V. Foltz, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; F. Gandjbakhch, MD, Practicing Rheumatologist; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; C. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; I. Eshed, MD, Associate Professor of Radiology, Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University; H.K. Genant, MD, FACR, FRCR, Professor Emeritus of Radiology, Medicine and Orthopedics, Departments of Radiology and Medicine, University of California San Francisco; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, University of Copenhagen; M. Kloppenburg, MD, PhD, Professor of Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center; I.K. Haugen, MD, PhD, Postdoctoral Researcher; Department of Rheumatology, Diakonhjemmet Hospital.
authors.forename: Violaine
authors.initials: V
authors.lastname: Foltz
authors.affiliation: From the Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie, Paris, France; Spire Sciences Inc., Boca Raton, Florida, USA; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Departments of Radiology and Medicine, University of California San Francisco, San Francisco, California, USA; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.|F.P. Kroon, MD, Department of Rheumatology, Leiden University Medical Center; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit; V. Foltz, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; F. Gandjbakhch, MD, Practicing Rheumatologist; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; C. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; I. Eshed, MD, Associate Professor of Radiology, Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University; H.K. Genant, MD, FACR, FRCR, Professor Emeritus of Radiology, Medicine and Orthopedics, Departments of Radiology and Medicine, University of California San Francisco; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, University of Copenhagen; M. Kloppenburg, MD, PhD, Professor of Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center; I.K. Haugen, MD, PhD, Postdoctoral Researcher; Department of Rheumatology, Diakonhjemmet Hospital.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Gandjbakhch
authors.affiliation: From the Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie, Paris, France; Spire Sciences Inc., Boca Raton, Florida, USA; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Departments of Radiology and Medicine, University of California San Francisco, San Francisco, California, USA; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.|F.P. Kroon, MD, Department of Rheumatology, Leiden University Medical Center; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit; V. Foltz, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; F. Gandjbakhch, MD, Practicing Rheumatologist; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; C. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; I. Eshed, MD, Associate Professor of Radiology, Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University; H.K. Genant, MD, FACR, FRCR, Professor Emeritus of Radiology, Medicine and Orthopedics, Departments of Radiology and Medicine, University of California San Francisco; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, University of Copenhagen; M. Kloppenburg, MD, PhD, Professor of Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center; I.K. Haugen, MD, PhD, Postdoctoral Researcher; Department of Rheumatology, Diakonhjemmet Hospital.
authors.forename: Charles
authors.initials: C
authors.lastname: Peterfy
authors.affiliation: From the Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie, Paris, France; Spire Sciences Inc., Boca Raton, Florida, USA; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Departments of Radiology and Medicine, University of California San Francisco, San Francisco, California, USA; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.|F.P. Kroon, MD, Department of Rheumatology, Leiden University Medical Center; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit; V. Foltz, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; F. Gandjbakhch, MD, Practicing Rheumatologist; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; C. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; I. Eshed, MD, Associate Professor of Radiology, Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University; H.K. Genant, MD, FACR, FRCR, Professor Emeritus of Radiology, Medicine and Orthopedics, Departments of Radiology and Medicine, University of California San Francisco; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, University of Copenhagen; M. Kloppenburg, MD, PhD, Professor of Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center; I.K. Haugen, MD, PhD, Postdoctoral Researcher; Department of Rheumatology, Diakonhjemmet Hospital.
authors.forename: Iris
authors.initials: I
authors.lastname: Eshed
authors.affiliation: From the Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie, Paris, France; Spire Sciences Inc., Boca Raton, Florida, USA; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Departments of Radiology and Medicine, University of California San Francisco, San Francisco, California, USA; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.|F.P. Kroon, MD, Department of Rheumatology, Leiden University Medical Center; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit; V. Foltz, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; F. Gandjbakhch, MD, Practicing Rheumatologist; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; C. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; I. Eshed, MD, Associate Professor of Radiology, Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University; H.K. Genant, MD, FACR, FRCR, Professor Emeritus of Radiology, Medicine and Orthopedics, Departments of Radiology and Medicine, University of California San Francisco; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, University of Copenhagen; M. Kloppenburg, MD, PhD, Professor of Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center; I.K. Haugen, MD, PhD, Postdoctoral Researcher; Department of Rheumatology, Diakonhjemmet Hospital.
authors.forename: Harry K
authors.initials: HK
authors.lastname: Genant
authors.affiliation: From the Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie, Paris, France; Spire Sciences Inc., Boca Raton, Florida, USA; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Departments of Radiology and Medicine, University of California San Francisco, San Francisco, California, USA; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.|F.P. Kroon, MD, Department of Rheumatology, Leiden University Medical Center; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit; V. Foltz, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; F. Gandjbakhch, MD, Practicing Rheumatologist; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; C. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; I. Eshed, MD, Associate Professor of Radiology, Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University; H.K. Genant, MD, FACR, FRCR, Professor Emeritus of Radiology, Medicine and Orthopedics, Departments of Radiology and Medicine, University of California San Francisco; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, University of Copenhagen; M. Kloppenburg, MD, PhD, Professor of Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center; I.K. Haugen, MD, PhD, Postdoctoral Researcher; Department of Rheumatology, Diakonhjemmet Hospital.
authors.forename: Mikkel
authors.initials: M
authors.lastname: Østergaard
authors.affiliation: From the Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie, Paris, France; Spire Sciences Inc., Boca Raton, Florida, USA; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Departments of Radiology and Medicine, University of California San Francisco, San Francisco, California, USA; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.|F.P. Kroon, MD, Department of Rheumatology, Leiden University Medical Center; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit; V. Foltz, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; F. Gandjbakhch, MD, Practicing Rheumatologist; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; C. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; I. Eshed, MD, Associate Professor of Radiology, Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University; H.K. Genant, MD, FACR, FRCR, Professor Emeritus of Radiology, Medicine and Orthopedics, Departments of Radiology and Medicine, University of California San Francisco; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, University of Copenhagen; M. Kloppenburg, MD, PhD, Professor of Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center; I.K. Haugen, MD, PhD, Postdoctoral Researcher; Department of Rheumatology, Diakonhjemmet Hospital.
authors.forename: Margreet
authors.initials: M
authors.lastname: Kloppenburg
authors.affiliation: From the Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie, Paris, France; Spire Sciences Inc., Boca Raton, Florida, USA; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Departments of Radiology and Medicine, University of California San Francisco, San Francisco, California, USA; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.|F.P. Kroon, MD, Department of Rheumatology, Leiden University Medical Center; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research, Leeds Musculoskeletal Biomedical Research Unit; V. Foltz, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; F. Gandjbakhch, MD, Practicing Rheumatologist; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; C. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; I. Eshed, MD, Associate Professor of Radiology, Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University; H.K. Genant, MD, FACR, FRCR, Professor Emeritus of Radiology, Medicine and Orthopedics, Departments of Radiology and Medicine, University of California San Francisco; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, University of Copenhagen; M. Kloppenburg, MD, PhD, Professor of Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center; I.K. Haugen, MD, PhD, Postdoctoral Researcher; Department of Rheumatology, Diakonhjemmet Hospital.
authors.forename: Ida K
authors.initials: IK
authors.lastname: Haugen
mesh_terms: D000368:Aged; D052737:Carpometacarpal Joints / Q000000981:diagnostic imaging*; D002358:Cartilage, Articular / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging*; D054850:Osteophyte / Q000000981:diagnostic imaging; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013585:Synovitis / Q000000981:diagnostic imaging*; D013933:Thumb / Q000000981:diagnostic imaging*
keywords: HAND; MAGNETIC RESONANCE IMAGING; OMERACT; OSTEOARTHRITIS; OUTCOMES RESEARCH; THUMB BASE