title: Electric field estimation of deep transcranial magnetic stimulation clinically used for the treatment of neuropsychiatric disorders in anatomical head models.
abstract: Literature studies showed the ability to treat neuropsychiatric disorders using H1 coil, developed for the deep Transcranial Magnetic Stimulation (dTMS). Despite the positive results of the clinical studies, the electric field (E) distributions inside the brain induced by this coil when it is positioned on the scalp according to the clinical studies themselves are not yet precisely estimated. This study aims to characterize the E distributions due to the H1 coil in the brain of two realistic human models by computational electromagnetic techniques and to compare them with the ones due to the figure-of-8 coil, traditionally used in TMS and positioned as such to simulate the clinical experiments. Despite inter-individual differences, our results show that the dorsolateral prefrontal cortex is the region preferentially stimulated by both H1 and figure-of-8 coil when they are placed in the position on the scalp according to the clinical studies, with a more broad and non-focal distribution in the case of H1 coil. Moreover, the H1 coil spreads more than the figure-of-8 coil both in the prefrontal cortex and medial prefrontal cortex and towards some deeper brain structures and it is characterized by a higher penetration depth in the frontal lobe. This work highlights the importance of the knowledge of the electric field distribution in the brain tissues to interpret the outcomes of the experimental studies and to optimize the treatments.
authors.affiliation: Consiglio Nazionale delle Ricerche - Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni, Piazza Leonardo da Vinci 32 - 20133 Milano, Italy. Electronic address: marta.parazzini@ieiit.cnr.it.
authors.forename: Marta
authors.initials: M
authors.lastname: Parazzini
authors.affiliation: Consiglio Nazionale delle Ricerche - Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni, Piazza Leonardo da Vinci 32 - 20133 Milano, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Fiocchi
authors.affiliation: Consiglio Nazionale delle Ricerche - Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni, Piazza Leonardo da Vinci 32 - 20133 Milano, Italy.
authors.forename: Emma
authors.initials: E
authors.lastname: Chiaramello
authors.affiliation: Department of Life Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel.
authors.forename: Yiftach
authors.initials: Y
authors.lastname: Roth
authors.affiliation: Department of Life Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel.
authors.forename: Abraham
authors.initials: A
authors.lastname: Zangen
authors.affiliation: Consiglio Nazionale delle Ricerche - Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni, Piazza Leonardo da Vinci 32 - 20133 Milano, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Ravazzani
mesh_terms: D000328:Adult; D004560:Electricity; D006257:Head / Q000473:pathology*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000473:pathology* / Q000628:therapy*; D008953:Models, Anatomic; D050781:Transcranial Magnetic Stimulation
keywords: Computational modeling; Deep transcranial magnetic stimulation; High-resolution head modeling; Neuropsychiatric disorders