title: C-peptide is independent associated with diabetic peripheral neuropathy: a community-based study.
abstract: BACKGROUND
  Because the relationship between C-peptide and diabetic peripheral neuropathy (DPN) is controversial, the aim of our study was to evaluate the relationship between C-peptide and DPN in community-based Chinese patients with type 2 diabetes.
  
  
  METHODS
  In total, 220 consecutive type 2 diabetic patients treated by our regional medical consortium were enrolled. DPN was assessed by clinical symptoms, signs, and electromyography.
  
  
  RESULTS
  Fasting C-peptide, 2-h postprandial C-peptide and ΔC-peptide (i.e., 2-h postprandial C-peptide minus the fasting C-peptide) serum concentrations in the non-DPN group were significantly higher than those in the clinical DPN group (allP≤ 0.040) and the confirmed DPN group (allP< 0.002). The three C-peptide parameters were independently associated with DPN (allP< 0.05) after adjusting for age, sex, diabetes duration, smoking status, systolic pressure, body mass index, angiotensin-converting enzyme inhibitors/angiotensin receptor blocker use, fasting plasma glucose, HbA1c, triglyceride and estimated glomerular filtration rate. Compared with the ΔC-peptide quartile 1 (reference), patients in quartile 3 (odds ratio [OR], 0.110; 95% confidence interval [CI] 0.026-0.466;P= 0.003) and quartile 4 (OR, 0.012; 95% CI 0.026-0.559;P= 0.007) had a lower risk of DPN after adjusting for the confounders.
  
  
  CONCLUSIONS
  C-peptide was negatively associated with DPN in community-based Chinese type 2 diabetic patients in China.
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040 China.
authors.forename: Xiaona
authors.initials: X
authors.lastname: Qiao
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040 China.
authors.forename: Hangping
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040 China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040 China.
authors.forename: Siying
authors.initials: S
authors.lastname: Liu
authors.affiliation: Departments of Endocrinology and Metabolism, Huashan Hospital Jing'an Branch, Fudan University, Shanghai, 200040 China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040 China.
authors.forename: Fei
authors.initials: F
authors.lastname: Mao
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040 China.
authors.forename: Zhaoyun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040 China.|Departments of Endocrinology and Metabolism, Huashan Hospital Jing'an Branch, Fudan University, Shanghai, 200040 China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wen
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040 China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Ye
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040 China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040 China.
authors.forename: Bin
authors.initials: B
authors.lastname: Lu
keywords: Beta-cell function; C-peptide; Community-based; Diabetic peripheral neuropathy