title: Myeloid sarcoma: a report of four cases at unusual sites.
abstract: Background:Myeloid sarcoma (MS) or granulocytic sarcoma is a rare tumor consisting of myeloid blasts with or without maturation occurring at anatomic sites other than the bone marrow. MS can involve any organ system but shows a predilection for skin, bone, and soft tissues of head and neck region.Case report:We report four cases of MS occurring at unusual sites, out of which three were de novo and one was associated with acute myeloid leukemia (AML).Conclusion:Although MS is associated with AML, it can rarely present without any existent hematologic disease. Differential diagnosis of a soft tissue mass should include MS even in the absence of leukemia. Establishment of the correct diagnosis depends on morphologic, histochemical, and immunohistochemical examination.
authors.affiliation: National Institute of Pathology, ICMR, Safdarjung Hospital Campus, New Delhi, India.
authors.forename: Fouzia
authors.initials: F
authors.lastname: Siraj
authors.affiliation: National Institute of Pathology, ICMR, Safdarjung Hospital Campus, New Delhi, India.
authors.forename: Manveen
authors.initials: M
authors.lastname: Kaur
authors.affiliation: National Institute of Pathology, ICMR, Safdarjung Hospital Campus, New Delhi, India.
authors.forename: Varsha
authors.initials: V
authors.lastname: Dalal
authors.affiliation: National Institute of Pathology, ICMR, Safdarjung Hospital Campus, New Delhi, India.
authors.forename: Ashima
authors.initials: A
authors.lastname: Khanna
authors.affiliation: JLNM Hospital, Srinagar, India.
authors.forename: Afaq Ahmad
authors.initials: AA
authors.lastname: Khan
mesh_terms: D000328:Adult; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000473:pathology*; D002530:Cerebellopontine Angle / Q000473:pathology*; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology; D009669:Nose Neoplasms / Q000175:diagnosis / Q000473:pathology*; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000473:pathology*; D010502:Perineum / Q000473:pathology*; D023981:Sarcoma, Myeloid / Q000175:diagnosis / Q000473:pathology*
keywords: acute leukemia; extramedullary; granulocytic sarcoma; myeloid sarcoma