title: Evaluation of the Bitterness-Masking Effect of Powdered Roasted Soybeans.
abstract: The masking of bitterness is considered important because many pharmaceutical compounds have a bitter taste. The bitterness-masking effect of powdered roasted soybeans (PRS) was investigated using a bitter taste sensor. PRS was revealed to significantly suppress the bitterness of quinine hydrochloride and denatonium benzoate. Furthermore, the bitterness-masking mechanism of PRS extracts was evaluated using dynamic light scattering. These results showed that the extracted suspension consisted of particles that were several hundreds of nanometers in size. Analysis of the PRS extracts by nuclear magnetic resonance spectroscopy indicated that denatonium benzoate was entrapped in the PRS extracts. Thus, PRS may be useful as a bitterness-masking agent in orally administered pharmaceuticals.
authors.affiliation: Department of Chemistry, Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata, Osaka 573-1121, Japan. makita@cc.osaka-dent.ac.jp.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Makita
authors.affiliation: Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata, Osaka 573-1121, Japan. s11010@stu.osaka-dent.ac.jp.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ishida
authors.affiliation: Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata, Osaka 573-1121, Japan. s11048@stu.osaka-dent.ac.jp.
authors.forename: Noriko
authors.initials: N
authors.lastname: Kobayashi
authors.affiliation: Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata, Osaka 573-1121, Japan. s11096@stu.osaka-dent.ac.jp.
authors.forename: Mai
authors.initials: M
authors.lastname: Fujio
authors.affiliation: Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata, Osaka 573-1121, Japan. s11098@stu.osaka-dent.ac.jp.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Fujimoto
authors.affiliation: Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata, Osaka 573-1121, Japan. s11113@stu.osaka-dent.ac.jp.
authors.forename: Rina
authors.initials: R
authors.lastname: Moritomo
authors.affiliation: Department of English, Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata, Osaka 573-1121, Japan. fujita-j@cc.osaka-dent.ac.jp.
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Fujita
authors.affiliation: Department of Chemistry, Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata, Osaka 573-1121, Japan. fujiwara@cc.osaka-dent.ac.jp.
authors.forename: Shin-Ichi
authors.initials: SI
authors.lastname: Fujiwara
keywords: bitterness; denatonium benzoate; masking effect; powdered roasted soybean; quinine hydrochloride