title: Clinical Trials with Oncolytic Measles Virus: Current Status and Future Prospects.
abstract: Attenuated Edmonston lineage measles virus (MV-Edm) vaccine strains can preferentially infect and lyse a wide variety of cancer cells. Oncolytic MV-Edm derivatives are genetically engineered to express the human carcinoembryonic antigen (MV-CEA virus) or the human sodium iodide symporter (MV-NIS virus) and are currently being tested in clinical trials against ovarian cancer, glioblastoma multiforme, multiple myeloma, mesothelioma, head and neck cancer, breast cancer and malignant peripheral nerve sheath tumors. This review describes the basic and preclinical data that facilitated the clinical translation of MV-Edm strains, and summarizes the clinical results of this oncolytic platform to date. Furthermore, we discuss the latest clinically relevant MV-Edm vector developments and creative strategies for future translational steps.
authors.affiliation: MD Anderson Cancer Center, Division of Cancer Medicine, 1400 Holcombe Blvd, Unit 0463, Houston, TX 77030, USA.
authors.forename: Pavlos
authors.initials: P
authors.lastname: Msaouel
authors.affiliation: Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, USA.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Opyrchal
authors.affiliation: Division of Hematology, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA.|Department of Molecular Medicine, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Dispenzieri
authors.affiliation: Department of Molecular Medicine, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Kah Whye
authors.initials: KW
authors.lastname: Peng
authors.affiliation: Department of Molecular Medicine, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Federspiel
authors.affiliation: Division of Hematology, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA.|Department of Molecular Medicine, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Russell
authors.affiliation: Department of Molecular Medicine, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA.|Division of Medical Oncology, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Evanthia
authors.initials: E
authors.lastname: Galanis
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D008459:Measles virus / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D050130:Oncolytic Virotherapy; D016896:Treatment Outcome
keywords: Cancer gene therapy; MV-CEA; MV-NIS; measles virus clinical trials; oncolytic measles; virotherapy