title: Alzheimer's biomarkers in daily practice (ABIDE) project: Rationale and design.
abstract: BACKGROUND
  The Alzheimer's biomarkers in daily practice (ABIDE) project is designed to translate knowledge on diagnostic tests (magnetic resonance imaging [MRI], cerebrospinal fluid [CSF], and amyloid positron emission tomography [PET]) to daily clinical practice with a focus on mild cognitive impairment (MCI).
  
  
  METHODS
  ABIDE is a 3-year project with a multifaceted design and is structured into interconnected substudies using both quantitative and qualitative research methods.
  
  
  RESULTS
  Based on retrospective data, we develop personalized risk estimates for MCI patients. Prospectively, we collect MRI and CSF data from 200 patients from local memory clinics and amyloid PET from 500 patients in a tertiary setting, to optimize application of these tests in daily practice. Furthermore, ABIDE will develop strategies for optimal patient-clinician conversations.
  
  
  CONCLUSIONS
  Ultimately, this will result in a set of practical tools for clinicians to support the choice of diagnostic tests and facilitate the interpretation and communication of their results.
authors.affiliation: Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Arno
authors.initials: A
authors.lastname: de Wilde
authors.affiliation: Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Ingrid S
authors.initials: IS
authors.lastname: van Maurik
authors.affiliation: Department of Medical Psychology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Marleen
authors.initials: M
authors.lastname: Kunneman
authors.affiliation: Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Femke
authors.initials: F
authors.lastname: Bouwman
authors.affiliation: Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Marissa
authors.initials: M
authors.lastname: Zwan
authors.affiliation: Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Eline A J
authors.initials: EA
authors.lastname: Willemse
authors.affiliation: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Geert Jan
authors.initials: GJ
authors.lastname: Biessels
authors.affiliation: Vilans, Utrecht, The Netherlands.
authors.forename: Mirella
authors.initials: M
authors.lastname: Minkman
authors.affiliation: Vilans, Utrecht, The Netherlands.
authors.forename: Ruth
authors.initials: R
authors.lastname: Pel
authors.affiliation: Department of Neurology, Spaarne Gasthuis, Haarlem, The Netherlands.
authors.forename: Niki S M
authors.initials: NS
authors.lastname: Schoonenboom
authors.affiliation: Department of Medical Psychology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Ellen M A
authors.initials: EM
authors.lastname: Smets
authors.affiliation: Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Mike P
authors.initials: MP
authors.lastname: Wattjes
authors.affiliation: Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands; Institutes of Neurology and Healthcare Engineering, UCL, London, UK.
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
authors.affiliation: Piramal Imaging GmbH, Berlin, Germany.
authors.forename: Andrew
authors.initials: A
authors.lastname: Stephens
authors.affiliation: BV Cyclotron, Amsterdam, The Netherlands.
authors.forename: Erik J
authors.initials: EJ
authors.lastname: van Lier
authors.affiliation: Roche Diagnostics, Basel, Switzerland.
authors.forename: Richard
authors.initials: R
authors.lastname: Batrla-Utermann
authors.affiliation: Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.affiliation: Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Charlotte E
authors.initials: CE
authors.lastname: Teunissen
authors.affiliation: Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Bart N M
authors.initials: BN
authors.lastname: van Berckel
authors.affiliation: Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Wiesje M
authors.initials: WM
authors.lastname: van der Flier
keywords: Alzheimer's disease; Biomarkers; Clinical practice; Dementia; Mild cognitive impairment