title: [Application strategies of the third-generation EGFR-TKI in the context of precision medicine].
abstract: With the advances in molecular detection technology and the emergence of various targeted agents, we have entered the era of precision medicine across the whole process of cancer diagnosis and treatment. Tyrosine kinase inhibitors targeting epidermal growth factor receptor gene mutation, the most common driver, have been developed from the first generation to the third generation, improving the survival and life quality of patients with advanced non-small cell lung cancer. It is critically important how to rank these targeted agents and arrange combination therapies, and this review will focus on the strategies of the third-generation EGFR-TKI in the context of precision medicine.
authors.affiliation: Department of Medical Oncology, Shanghai Pulmomary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Medical Oncology, Shanghai Pulmomary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
authors.forename: S J
authors.initials: SJ
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, Shanghai Pulmomary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
authors.forename: C C
authors.initials: CC
authors.lastname: Zhou
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D003131:Combined Modality Therapy; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D009154:Mutation; D057285:Precision Medicine; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D066246:ErbB Receptors
keywords: Carcinoma, non-small-cell lung; Epidermal growth factor receptor; Precision medicine; Tyrosine kinase inhibitor