title: Comparison of the effects of sugammadex and neostigmine on postoperative nausea and vomiting.
abstract: OBJECTIVE
  The aim of our study is to compare the effects of sugammadex and neostigmine, used for neuromuscular blockage antagonism, on postoperative nausea and vomiting (PONV).
  
  
  METHODS
  Our study was completed with 98 ASA I-II risk patients undergoing endotracheal intubation under general anesthesia. At the end of the surgery patients were randomly divided into two groups given 2mgkg-1sugammadex (Group S) or 50μgkg-1neostigmine plus 0.2mgkg-1atropine (Group N). Monitoring and recording times were set as 1 hour postoperative and from 1-6, 6-12, and 12-24hours. The anti-emetic amounts administered were recorded.
  
  
  RESULTS
  In the first hour postoperative 13 patients in Group N (27%) and 4 in Group S (8%) were observed to have nausea and/or vomiting and the difference was statistically significant (p=0.0016). During the 24 hours of monitoring there was no significant difference in the incidence and severity of PONV (p>0.05), however the number of patients given ondansetron for PONV treatment in Group N was statistically significantly higher than the number in Group S (16 in Group N, 6 in Group S, p<0.011).
  
  
  CONCLUSIONS
  At the end of our study comparing neostigmine with sugammadex for neuromuscular blockage antagonism, we found use of sugammadex had lower incidence of PONV in the postoperative 1st hour and less anti-emetic use in 24 hours of monitoring.
authors.affiliation: Ordu University, School of Medicine, Department of Anesthesiology, Ordu, Turkey. Electronic address: ozguryagan@hotmail.com.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Yağan
authors.affiliation: Ordu University, School of Medicine, Department of Anesthesiology, Ordu, Turkey.
authors.forename: Nilay
authors.initials: N
authors.lastname: Taş
authors.affiliation: Ordu University, School of Medicine, Department of Anesthesiology, Ordu, Turkey.
authors.forename: Tuğçe
authors.initials: T
authors.lastname: Mutlu
authors.affiliation: Dokuz Eylul University, School of Medicine, Department of Anesthesiology, Alsancak, Izmir, Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Hancı
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000379:methods; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D001285:Atropine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015994:Incidence; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D009388:Neostigmine / Q000008:administration & dosage* / Q000009:adverse effects; D019148:Neuromuscular Blockade; D017294:Ondansetron / Q000008:administration & dosage / Q000627:therapeutic use; D020250:Postoperative Nausea and Vomiting / Q000139:chemically induced / Q000453:epidemiology*; D011446:Prospective Studies; D012720:Severity of Illness Index; D016037:Single-Blind Method; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000932:Antiemetics; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D009388:Neostigmine; D017294:Ondansetron; D001285:Atropine
keywords: Nausea; Neostigmina; Neostigmine; Náusea; Postoperative; Pós-operatório; Sugammadex; Vomiting; Vômito