title: Effects of Aspirin and Intrauterine Balloon on Endometrial Repair and Reproductive Prognosis in Patients with Severe Intrauterine Adhesion: A Prospective Cohort Study.
abstract: This study aimed to investigate the effects of estrogen in combination with aspirin and intrauterine balloon on the uterine endometrial repair and reproductive prognosis in patients after surgery for severe intrauterine adhesion (sIUA). We prospectively recruited 114 patients with sIUA. Intrauterine device (IUD) was placed and oral estrogen was administered after surgery. Patients were divided into control group and aspirin group. In addition, patients in aspirin group were subdivided into nonballoon group and balloon group. Results showed that, after therapy, the increase in endometrial thickness of aspirin groups was superior to control group (P< 0.05). The scores of intrauterine adhesion and menstruation were significantly improved in balloon group as compared to nonballoon group and control group, and significant differences were also observed between nonballoon group and control group (P< 0.05). Of 97 patients, 44.3% became pregnant after surgery, the live birth rate was 27.8%, and the miscarriage rate was 37.2%, but there were no significant differences among three groups (P> 0.05). Thus, aspirin may promote the uterine endometrial growth and repair after surgery for sIUA, and IUD in combination with intrauterine balloon may reduce the recurrence of intrauterine adhesion, but their effect on the reproductive prognosis is required to be further studied.
authors.affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Yuqing
authors.identifier: 0000-0002-1824-9168
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Lixiang
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Yuanna
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Minghui
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Yang
authors.identifier: 0000-0001-8511-2172
authors.initials: Y
authors.lastname: Huan
authors.affiliation: Department of Gynecology Ward II, Shenzhen Luohu People's Hospital, Shenzhen 518000, China.
authors.forename: Ruili
authors.initials: R
authors.lastname: Fang
mesh_terms: D000328:Adult; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D004717:Endometrium / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008598:Menstruation / Q000187:drug effects; D011182:Postoperative Care; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D012098:Reproduction / Q000187:drug effects*; D000267:Tissue Adhesions / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D058738:Uterine Balloon Tamponade; D014591:Uterine Diseases / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001241:Aspirin