title: Helicobacter pylori virulence factors in relation to gastrointestinal diseases in Iran.
abstract: OBJECTIVE
  Helicobacter pylori as an important pathogenic bacterium that colonizes in gastric mucosa, is one of the causative agents in development of some types of gastric diseases, such as chronic active gastritis, peptic ulcer disease (PUD) and gastric cancer (GC). In this review, the aim is studying different genotypes of H. pylori, and the extent of their participation in the pathogenesis of this bacterium which creates gastroduodenal disorders.
  
  
  RESULTS
  Some genotypes of H. pylori have a major role in creation of gastroduodenal diseases, whereas some other genotypes of the bacterium do not cause gastric diseases in Iran. It was also reported that some genotypes of this bacterium in different conditions and among different ethnic groups demonstrate different effectiveness.
  
  
  CONCLUSIONS
  Role of genotypes of H. pylori in creation of gastroduodenal diseases is different among various regions and ethnic groups of Iran.
authors.affiliation: Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Electronic address: safaralizadeh@tabrizu.ac.ir.
authors.forename: Reza
authors.initials: R
authors.lastname: Safaralizadeh
authors.affiliation: Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Electronic address: n_dastmalchi93@tabrizu.ac.ir.
authors.forename: Narges
authors.initials: N
authors.lastname: Dastmalchi
authors.affiliation: Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Electronic address: pourfeizi@eastp.ir.
authors.forename: MohammadAli
authors.initials: M
authors.lastname: Hosseinpourfeizi
authors.affiliation: Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran. Electronic address: slatifin@yahoo.com.
authors.forename: Saeid
authors.initials: S
authors.lastname: Latifi-Navid
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D005767:Gastrointestinal Diseases / Q000382:microbiology*; D005787:Gene Frequency; D005838:Genotype; D016481:Helicobacter Infections / Q000208:ethnology / Q000235:genetics / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D007492:Iran; D037521:Virulence Factors / Q000235:genetics
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C528428:DupA protein, Helicobacter pylori; C546056:HomB protein, Helicobacter pylori; C526444:OipA protein, Helicobacter pylori; C103937:PicB protein, Helicobacter pylori; C074689:VacA protein, Helicobacter pylori; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori
keywords: Gastric cancer; Genotypes; Helicobacter pylori; Iran