title: Convergent evolution of the adaptive immune response in jawed vertebrates and cyclostomes: An evolutionary biology approach based study.
abstract: Two different adaptive immune systems (AIS) are present in the two phyla of vertebrates (jawed vertebrates and cyclostomes). The jawed vertebrate system is based on IG/TCR/RAG/MHC while the cyclostome system is based on VLRCs and AID-like enzymes both systems using homologous Cell types (B-cell and B-cell Like, T-cell and T-cell like). We will present our current view of the evolution of these two AISs and present alternative hypotheses that could explain the apparent convergent evolution of the two systems. We will also discuss why comparative immunology analyses should be based on evolutionary biology approaches and not on the scale of progress one.
authors.affiliation: Aix Marseille Université, CNRS, Centrale Marseille, I2M UMR 7373, équipe évolution biologique modélisation, 13453, Marseille, France.
authors.forename: Jose Ricardo
authors.initials: JR
authors.lastname: Morales Poole
authors.affiliation: XEGEN, 15 rue de la République, 13420, Gémenos, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Paganini
authors.affiliation: Aix Marseille Université, CNRS, Centrale Marseille, I2M UMR 7373, équipe évolution biologique modélisation, 13453, Marseille, France. Electronic address: pierre.pontarotti@univ-amu.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Pontarotti
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D005075:Biological Evolution; D019143:Evolution, Molecular; D005398:Fisheries; D006196:Hagfishes / Q000276:immunology*; D006801:Humans; D007568:Jaw; D007798:Lampreys / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D011946:Receptors, Antigen / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*; D014714:Vertebrates / Q000276:immunology*
chemical_list: D011946:Receptors, Antigen