title: Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204.
abstract: The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains.In vivomodulation of miRNA expression in mouse embryos confirmed that miR-34c and miR-204 can control neuronal migration and cortical morphogenesis, presumably by posttranscriptional regulation of DCX.
authors.affiliation: Department of Molecular Biology and Genetics, Interdisciplinary Nanoscience Center, Aarhus University Aarhus, Denmark.
authors.forename: Morten T
authors.initials: MT
authors.lastname: Venø
authors.affiliation: Department of Molecular Biology and Genetics, Interdisciplinary Nanoscience Center, Aarhus University Aarhus, Denmark.
authors.forename: Susanne T
authors.initials: ST
authors.lastname: Venø
authors.affiliation: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht, Netherlands.
authors.forename: Kati
authors.initials: K
authors.lastname: Rehberg
authors.affiliation: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht, Netherlands.
authors.forename: Jessy V
authors.initials: JV
authors.lastname: van Asperen
authors.affiliation: Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark Odense, Denmark.
authors.forename: Bettina H
authors.initials: BH
authors.lastname: Clausen
authors.affiliation: Laboratory for Experimental Neuropathology, Department of Pathology, Randers Hospital Randers, Denmark.
authors.forename: Ida E
authors.initials: IE
authors.lastname: Holm
authors.affiliation: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht, Netherlands.
authors.forename: R Jeroen
authors.initials: RJ
authors.lastname: Pasterkamp
authors.affiliation: Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark Odense, Denmark.
authors.forename: Bente
authors.initials: B
authors.lastname: Finsen
authors.affiliation: Department of Molecular Biology and Genetics, Interdisciplinary Nanoscience Center, Aarhus University Aarhus, Denmark.
authors.forename: Jørgen
authors.initials: J
authors.lastname: Kjems
keywords: brain development; cortical morphogenesis; embryonic development; miR-204; miR-34c; microRNA; neuronal migration