title: New insights into the ameliorative effects of ferulic acid in pathophysiological conditions.
abstract: Ferulic acid, a natural phytochemical has gained importance as a potential therapeutic agent by virtue of its easy commercial availability, low cost and minimal side-effects. It is a derivative of curcumin and possesses the necessary pharmacokinetic properties to be retained in the general circulation for several hours. The therapeutic effects of ferulic acid are mediated through its antioxidant and anti-inflammatory properties. It exhibits different biological activities such as anti-inflammatory, anti-apoptotic, anti-carcinogenic, anti-diabetic, hepatoprotective, cardioprotective, neuroprotective actions, etc. The current review addresses its therapeutic effects under different pathophysiological conditions (eg. cancer, cardiomyopathy, skin disorders, brain disorders, viral infections, diabetes etc.).
authors.affiliation: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors.forename: Sumit
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Basak
authors.affiliation: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors.forename: Sayanta
authors.initials: S
authors.lastname: Dutta
authors.affiliation: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
authors.forename: Sayantani
authors.initials: S
authors.lastname: Chowdhury
authors.affiliation: Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India. Electronic address: parames@jcbose.ac.in.
authors.forename: Parames C
authors.initials: PC
authors.lastname: Sil
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000473:pathology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D009202:Cardiomyopathies / Q000188:drug therapy; D002454:Cell Differentiation / Q000187:drug effects; D003373:Coumaric Acids / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D003474:Curcumin / Q000494:pharmacology / Q000627:therapeutic use; D048909:Diabetes Complications / Q000188:drug therapy; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D010300:Parkinson Disease / Q000188:drug therapy; D012583:Schwann Cells / Q000187:drug effects / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D003373:Coumaric Acids; C004999:ferulic acid; D003474:Curcumin
keywords: Antioxidant; Cancer; Cardiomyopathy; Diabetes; Ferulic acid; Inflammation; Neurodegenerative disorder