title: Design of simulated moving bed for separation of fumaric acid with a little fronting phenomenon.
abstract: The production of fumaric acid through a biotechnological pathway has grown in importance because of its potential value in related industries. This has sparked an interest in developing an economically-efficient process for separation of fumaric acid (product of interest) from acetic acid (by-product). This study aimed to develop a simulated moving bed (SMB) chromatographic process for such separation in a systematic way. As a first step for this work, commercially available adsorbents were screened for their applicability to the considered separation, which revealed that an Amberchrom-CG71C resin had a sufficient potential to become an adsorbent of the targeted SMB. Using this adsorbent, the intrinsic parameters of fumaric and acetic acids were determined and then applied to optimizing the SMB process under consideration. The optimized SMB process was tested experimentally, from which the yield of fumaric-acid product was found to become lower than expected in the design. An investigation about the reason for such problem revealed that it was attributed to a fronting phenomenon occurring in the solute band of fumaric acid. To resolve this issue, the extent of the fronting was evaluated quantitatively using an experimental axial dispersion coefficient for fumaric acid, which was then considered in the design of the SMB of interest. The SMB experimental results showed that the SMB design based on the consideration of the fumaric-acid fronting could guarantee the attainment of both high purity (>99%) and high yield (>99%) for fumaric-acid product under the desorbent consumption of 2.6 and the throughput of 0.36L/L/h.
authors.affiliation: Department of Chemical Engineering, Hanyang University, Haengdang-dong, Seongdong-gu, Seoul, 04763, South Korea.
authors.forename: Jae-Hwan
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Department of Chemical Engineering, Hanyang University, Haengdang-dong, Seongdong-gu, Seoul, 04763, South Korea.
authors.forename: Mun-Seok
authors.initials: MS
authors.lastname: Kang
authors.affiliation: Department of Chemical Engineering, Hanyang University, Haengdang-dong, Seongdong-gu, Seoul, 04763, South Korea.
authors.forename: Chung-Gi
authors.initials: CG
authors.lastname: Lee
authors.affiliation: School of Chemical Engineering,480 Stadium Mall Drive, Purdue University, West Lafayette, IN 47907-2100, USA.
authors.forename: Nien-Hwa Linda
authors.initials: NL
authors.lastname: Wang
authors.affiliation: Department of Chemical Engineering, Hanyang University, Haengdang-dong, Seongdong-gu, Seoul, 04763, South Korea. Electronic address: munsy@hanyang.ac.kr.
authors.forename: Sungyong
authors.initials: S
authors.lastname: Mun
mesh_terms: D019342:Acetic Acid; D002853:Chromatography, Liquid / Q000379:methods*; D005650:Fumarates / Q000302:isolation & purification*; D012107:Research Design
chemical_list: D005650:Fumarates; C032005:fumaric acid; D019342:Acetic Acid