title: A general three-step one-pot synthesis of novel (E)-6-chloro-2-(aryl/hetarylvinyl)quinoline-3-carboxylic acids.
abstract: In this work, a facile and general three-step one-pot synthesis of structurally new (E)-6-chloro-2-(aryl/hetarylvinyl)quinoline-3-carboxylic acid derivatives has been achieved from easily available ethyl 6-chloro-2-(chloromethyl) quinoline-3-carboxylate and aromatic or heteroaromatic aldehydes. This strategy features simple one-pot operation, tolerance of a wide range of substituents, and good yields. Moreover, these newly synthesized compounds belong to a new class of quinoline derivatives and could be good candidates for the development of more complex quinoline compounds for use in medicinal chemistry.
authors.affiliation: College of Land and Environmental Science, Shenyang Agricultural University, Shenyang, 110866, People's Republic of China. isfc_bhu@yeah.net.|Institute of Superfine Chemicals, Bohai University, Keji Street, Jinzhou, 121000, People's Republic of China. isfc_bhu@yeah.net.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Superfine Chemicals, Bohai University, Keji Street, Jinzhou, 121000, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Land and Environmental Science, Shenyang Agricultural University, Shenyang, 110866, People's Republic of China. 240117764@qq.com.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Zou
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D011804:Quinolines / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D011804:Quinolines
keywords: Aromatic aldehydes; Carboxylic acid; Quinoline; Three-step one-pot