title: Role of β2-microglobulin in postoperative cognitive decline.
abstract: OBJECTIVE
  β2-microglobulin (β2M) was proved to affect hippocampal functions in mice.
  
  
  METHODS
  Seventy-one patients undergoing aortic valve replacement were analyzed in prospective observational study. Kidney biomarkers and Mini Mental State Examinations (MMSEs) were performed before procedure, at discharge and after 6 months.
  
  
  RESULTS
  Patients with β2M increase over the median change (>0.42 mg/l) experienced a significant in-hospital drop in MMSE (p = 0.005). Patients with β2M increase over the median change also failed to improve a delayed-word-recall domain of the test (p = 0.826) while patients with a lower increase improved results in the domain (p = 0.004). After 6 months, MMSE improvement was associated with a significant decrease in β2M (p = 0.042).
  
  
  CONCLUSIONS
  These are the first in man data demonstrating relation between changes in cognition and β2M. The phenomenon was reversible which indicates its therapeutic potential.
authors.affiliation: Cardiac Intensive Therapy Clinic, Institute of Cardiology, Warsaw, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Załęska-Kocięcka
authors.affiliation: Neurology Clinic, Institute of Psychiatry & Neurology, Warsaw, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Jezierski
authors.affiliation: Acquired Valve Disease Clinic, Institute of Cardiology, Warsaw, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Grabowski
authors.affiliation: Cardiac Surgery & Transplantology Clinic, Institute of Cardiology, Warsaw, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kuśmierski
authors.affiliation: Interventional Cardiology & Angiology Clinic, Institute of Cardiology, Warsaw, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Dąbrowski
authors.affiliation: Department of Quantitative Methods & Information Technology, Kozminski University, Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Piotrowska
authors.affiliation: Cardiac Intensive Therapy Clinic, Institute of Cardiology, Warsaw, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Banaszewski
authors.affiliation: Department of Internal Medicine & Nephrology, Miedzyleski Hospital, Warsaw, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Imiela
authors.affiliation: Cardiac Intensive Therapy Clinic, Institute of Cardiology, Warsaw, Poland.
authors.forename: Janina
authors.initials: J
authors.lastname: Stępińska
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000473:pathology / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000378:metabolism; D000071068:Lipocalin-2 / Q000097:blood; D008297:Male; D016017:Odds Ratio; D011183:Postoperative Complications; D011446:Prospective Studies; D012720:Severity of Illness Index; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D015415:Biomarkers; D000071068:Lipocalin-2; D001613:beta 2-Microglobulin
keywords: aging; anesthesia; cognition; kidney biomarkers; postoperative cognitive decline; surgery; β2-microglobulin