title: [Ultrasound physiotherapy treatment of prostatitis].
abstract: OBJECTIVE
  Develop a method of treatment of prostatitis based on the use of a standard antibiotic, immunomodulatory therapy, and transrectal ultrasound physiotherapy.
  
  
  METHODS
  The dynamics of the accumulation of the antibiotic was investigated in male rats. Sonication was performed immediately before the administration of the antibiotic and its accumulation in the process at 10, 20, 40, 60, 80, 100 min after dosing. The clinical study included 138 patients with chronic prostatitis. Patients of the experimental group, in addition to standard therapy, 10 sessions of transrectal ultrasound physical therapy was performed. The efficacy of treatment was assessed after 14 and 28 days after initiation.
  
  
  RESULTS
  and its discussion. Experiments on laboratory animals have shown that the highest concentration and the residence time of antibiotic in the prostate tissue is noted ultrasonic treatment in the period of maximum blood concentration of the test drug. The data obtained allow to determine that the ultrasonic treatment must be performed considering the pharmacokinetics of the antibiotic. In conducting clinical trials on day 14 of treatment and clinical manifestations of prostatitis bacterial microflora in prostatic secretions were no patients in both groups. In 15% of patients of the experimental group the number of leukocytes decreased to the normal range. After 28 days the amount of leukocytes was normal in 51% of patients in the control and 85% in the experimental group.
  
  
  CONCLUSIONS
  In animal experiments defined the optimal time interval separating the moment of injection of the antibiotic from the beginning of sonication. Clinical studies have shown that the transrectal ultrasound exposure during the period of maximum concentration of the antibiotic in the blood, improves patient outcomes by 33.8%.
authors.affiliation: Peoples Friendship University of Russia, Moscow.
authors.forename: P I
authors.initials: PI
authors.lastname: Talberg
authors.affiliation: Peoples Friendship University of Russia, Moscow.
authors.forename: M I
authors.initials: MI
authors.lastname: Andryukhin
authors.affiliation: Lomonosov Moscow State University, Moscow.
authors.forename: S E
authors.initials: SE
authors.lastname: Mazina
authors.affiliation: Lomonosov Moscow State University, Moscow.
authors.forename: A L
authors.initials: AL
authors.lastname: Nikolaev
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001419:Bacteria / Q000302:isolation & purification; D002908:Chronic Disease; D006801:Humans; D056747:Immunomodulation; D064704:Levofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008297:Male; D026741:Physical Therapy Modalities; D011472:Prostatitis / Q000188:drug therapy / Q000382:microbiology / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014018:Tissue Distribution; D014464:Ultrasonic Therapy / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin
keywords: prostate; the concentration of the antibiotic; ultrasound treatment