title: Methadone-Induced Hyperhidrosis Treated With Oxybutynin.
abstract: This case report aims to help healthcare providers and methadone clinic patients to recognize one of the less recognized adverse effects of methadone, hyperhidrosis, and to suggest oxybutynin as a possible solution.
  
  
  
  A 35-year-old man on methadone maintenance therapy presented with excessive sweating, which began promptly after methadone was introduced. Urine toxicology was conducted every 2 weeks to rule out other illicit substances that may have contributed to the sweating.
  
  
  
  Oxybutynin (5 mg PO QID) resulted in cessation of the methadone-induced hyperhidrosis within 2 days of starting the medication.
  
  
  
  Methadone-induced excessive sweating is an adverse effect of the medication that reportedly affects up to 45% of those prescribed methadone, and oxybutynin is a potent treatment for methadone-induced excessive sweating.
authors.affiliation: Department of Psychiatry, Metropolitan Hospital Center, New York Medical College, New York, NY.
authors.forename: Joe
authors.initials: J
authors.lastname: Hong
authors.forename: Jooyeon
authors.initials: J
authors.lastname: Lee
authors.forename: Holly
authors.initials: H
authors.lastname: Totouom-Tangho
authors.forename: Norma Ramos
authors.initials: NR
authors.lastname: Dunn
authors.forename: Ronnie Gorman
authors.initials: RG
authors.lastname: Swift
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects*; D006801:Humans; D006945:Hyperhidrosis / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008333:Mandelic Acids / Q000627:therapeutic use*; D008691:Methadone / Q000009:adverse effects*; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D058850:Opiate Substitution Treatment / Q000009:adverse effects*
chemical_list: D000701:Analgesics, Opioid; D008333:Mandelic Acids; D018727:Muscarinic Antagonists; C005419:oxybutynin; D008691:Methadone