title: Clinical Parameters following Multiple Oral Dose Administration of a Standardized Andrographis paniculata Capsule in Healthy Thai Subjects.
abstract: Andrographis paniculatahas been widely used in Scandinavian and Asian counties for the treatment of the common cold, fever, and noninfectious diarrhea. The present study was carried out to investigate the physiological effects of short-term multiple dose administration of a standardizedA. paniculatacapsule used for treatment of the common cold and uncomplicated upper respiratory tract infections, including blood pressure, electrocardiogram, blood chemistry, hematological profiles, urinalysis, and blood coagulation in healthy Thai subjects. Twenty healthy subjects (10 males and 10 females) received 12 capsules per day orally of 4.2 g of a standardizedA. paniculatacrude powder (4 capsules of 1.4 g ofA. paniculata, 3 times per day, 8 h intervals) for 3 consecutive days. The results showed that all of the measured clinical parameters were found to be within normal ranges for a healthy person. However, modulation of some parameters was observed after the third day of treatment, for example, inductions of white blood cells and absolute neutrophil count in the blood, a reduction of plasma alkaline phosphatase, and an induction of urine pH. A rapid and transient reduction in blood pressure was observed at 30 min after capsule administration, resulting in a significant reduction of mean systolic blood pressure. There were no serious adverse events observed in the subjects during the treatment period. In conclusion, this study suggests that multiple oral dosing ofA. paniculataat the normal therapeutic dose for the common cold and uncomplicated upper respiratory tract infections modulates various clinical parameters within normal ranges for a healthy person.
authors.affiliation: Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand.|Center of Excellence on Environmental Health and Toxicology, Office of Higher Education Commission, Ministry of Education, Bangkok, Thailand.
authors.forename: Tawit
authors.initials: T
authors.lastname: Suriyo
authors.affiliation: Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand.
authors.forename: Nanthanit
authors.initials: N
authors.lastname: Pholphana
authors.affiliation: Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand.
authors.forename: Teerapat
authors.initials: T
authors.lastname: Ungtrakul
authors.affiliation: Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand.|Center of Excellence on Environmental Health and Toxicology, Office of Higher Education Commission, Ministry of Education, Bangkok, Thailand.|Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, Thailand.
authors.forename: Nuchanart
authors.initials: N
authors.lastname: Rangkadilok
authors.affiliation: Translational Research Unit, Chulabhorn Research Institute, Bangkok, Thailand.
authors.forename: Duangchit
authors.initials: D
authors.lastname: Panomvana
authors.affiliation: Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand.|Center of Excellence on Environmental Health and Toxicology, Office of Higher Education Commission, Ministry of Education, Bangkok, Thailand.|Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, Thailand.
authors.forename: Apinya
authors.initials: A
authors.lastname: Thiantanawat
authors.affiliation: Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand.
authors.forename: Wanwisa
authors.initials: W
authors.lastname: Pongpun
authors.affiliation: Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand.|Center of Excellence on Environmental Health and Toxicology, Office of Higher Education Commission, Ministry of Education, Bangkok, Thailand.|Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, Thailand.
authors.forename: Jutamaad
authors.initials: J
authors.lastname: Satayavivad
mesh_terms: D000284:Administration, Oral; D000328:Adult; D035685:Andrographis; D001774:Blood Chemical Analysis; D001777:Blood Coagulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D002214:Capsules; D005260:Female; D006801:Humans; D008297:Male; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage / Q000494:pharmacology*; D011674:Pulse; D013785:Thailand
chemical_list: D002214:Capsules; D028321:Plant Preparations