title: Complexes of myo-Inositol-Hexakisphosphate (IP6) with Zinc or Lanthanum for the Decorporation of Radiocesium.
abstract: Radioactive nuclides leak into the surrounding environment after nuclear power plant disasters, such as the Chernobyl accident and the Fukushima Daiichi Nuclear Power Plant disaster. Cesium-137 (137Cs) (t1/2=30.1 year), a water-soluble radionuclide with a long physical half-life, contaminates aquatic ecosystems and food products. In humans,137Cs concentrates in muscle tissue and has a long biological half-life, indicating it may be harmful. myo-Inositol-hexakisphosphate (IP6) is a compound found in grain, beans, and oil seeds. IP6 has the ability to form insoluble complexes with metals, including lanthanum (La) and zinc (Zn). We hypothesized that La-IP6 and Zn-IP6 may promote the elimination of137Cs from the body through the adsorption of La-IP6 and Zn-IP6 to137Cs in the gastrointestinal tract. Therefore, in this study, we evaluated the adsorptive capacity of La-IP6 and Zn-IP6 complexes with137Cs in vitro and in vivo. La-IP6 and Zn-IP6 complexes were stable in acidic solution (pH 1.2) at 37°C. In vitro binding assays indicated that La-IP6 and Zn-IP6 complexes adsorbed137Cs, with the adsorption capacity of Zn-IP6 to137Cs greater than that of La-IP6. To evaluate the usefulness of La-IP6 and Zn-IP6 in vivo, La-IP6 or Zn-IP6 was administrated to mice after intravenous injection of137Cs. However, the biodistribution of137Cs in the La-IP6 treated group and the Zn-IP6 treated group was nearly identical to the non-treated control group, indicating that La-IP6 and Zn-IP6 were not effective at promoting the elimination of137Cs in vivo.
authors.affiliation: Graduate School of Medical Sciences, Kanazawa University.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ogawa
authors.forename: Miho
authors.initials: M
authors.lastname: Aoki
authors.forename: Tadahisa
authors.initials: T
authors.lastname: Fukuda
authors.forename: Sumi
authors.initials: S
authors.lastname: Kadono
authors.forename: Tatsuto
authors.initials: T
authors.lastname: Kiwada
authors.forename: Akira
authors.initials: A
authors.lastname: Odani
mesh_terms: D000284:Administration, Oral; D000327:Adsorption; D000818:Animals; D002118:Calcium / Q000737:chemistry; D002588:Cesium Radioisotopes / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D007811:Lanthanum / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010833:Phytic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D011188:Potassium / Q000737:chemistry; D012964:Sodium / Q000737:chemistry; D014018:Tissue Distribution; D015032:Zinc / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: D002588:Cesium Radioisotopes; D007811:Lanthanum; D010833:Phytic Acid; D012964:Sodium; D015032:Zinc; D011188:Potassium; D002118:Calcium