title: Electrochemical [11C]CO2to [11C]CO conversion for PET imaging.
abstract: The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [11C]CO from [11C]CO2. Produced [11C]CO was subsequently converted to [11C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98%.
authors.affiliation: Department of Chemistry, Imperial College London, London SW7 2AZ, UK. n.long@imperial.ac.uk and Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, London SE1 7EH, UK.
authors.forename: David A
authors.initials: DA
authors.lastname: Anders
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, London SE1 7EH, UK.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Bongarzone
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, London SE1 7EH, UK.
authors.forename: Robin
authors.initials: R
authors.lastname: Fortt
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, London SE1 7EH, UK.
authors.forename: Antony D
authors.initials: AD
authors.lastname: Gee
authors.affiliation: Department of Chemistry, Imperial College London, London SW7 2AZ, UK. n.long@imperial.ac.uk.
authors.forename: Nicholas J
authors.identifier: http://orcid.org/0000-0002-8298-938X
authors.initials: NJ
authors.lastname: Long