title: Gold-catalyzed highly regio- and enantioselective vinylcarbene insertion into O-H bonds of 2-pyridones.
abstract: The first gold-catalyzed highly regio- and enantioselective carbene insertion into the O-H bonds of 2-pyridones has been realized in the presence of catalytic amounts of chiral dual-gold complexes. The corresponding chiral products were obtained in moderate to good yields, excellent O-selectivity, excellent carbenic selectivity and moderate to excellent enantioselectivities (up to 96% ee).
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology and School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun@cczu.edu.cn jtsun08@gmail.com.
authors.forename: Daorui
authors.initials: D
authors.lastname: Huang
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology and School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun@cczu.edu.cn jtsun08@gmail.com.
authors.forename: Guangyang
authors.initials: G
authors.lastname: Xu
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology and School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun@cczu.edu.cn jtsun08@gmail.com.
authors.forename: Shiyong
authors.initials: S
authors.lastname: Peng
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology and School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun@cczu.edu.cn jtsun08@gmail.com.
authors.forename: Jiangtao
authors.identifier: http://orcid.org/0000-0003-2516-3466
authors.initials: J
authors.lastname: Sun