title: The role of extracorporeal photopheresis in the management of cutaneous T-cell lymphoma, graft-versus-host disease and organ transplant rejection: a consensus statement update from the UK Photopheresis Society.
abstract: Extracorporeal photopheresis (ECP) has been used for over 35 years in the treatment of erythrodermic cutaneous T-cell lymphoma (CTCL) and over 20 years for chronic and acute graft-versus-host disease (GvHD) and solid organ transplant rejection. ECP for CTCL and GvHD is available at specialised centres across the UK. The lack of prospective randomised trials in ECP led to the development of UK Consensus Statements for patient selection, treatment schedules, monitoring protocols and patient assessment criteria for ECP. The recent literature has been reviewed and considered when writing this update. Most notably, the national transition from the UVAR XTS®machine to the new CELLEX machine for ECP with dual access and a shorter treatment time has led to relevant changes in these schedules. This consensus statement updates the previous statement from 2007 on the treatment of CTCL and GvHD with ECP using evidence based medicine and best medical practise and includes guidelines for both children and adults.
authors.affiliation: Rotherham Foundation NHS Trust, Rotherham, UK.
authors.forename: Arun
authors.initials: A
authors.lastname: Alfred
authors.affiliation: Rotherham Foundation NHS Trust, Rotherham, UK.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Taylor
authors.affiliation: Central Manchester NHS Foundation Trust, Manchester, UK.
authors.forename: Fiona
authors.initials: F
authors.lastname: Dignan
authors.affiliation: Therapeutics and Tissue Services, NHS Blood and Transplant, Sheffield, UK.
authors.forename: Khaled
authors.initials: K
authors.lastname: El-Ghariani
authors.affiliation: University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
authors.forename: James
authors.initials: J
authors.lastname: Griffin
authors.affiliation: Institute of Cellular Medicine, Newcastle University and Great North Children's Hospital, Newcastle-Upon-Tyne, UK.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Gennery
authors.affiliation: Royal Manchester Children's Hospital, Manchester, UK.
authors.forename: Denise
authors.initials: D
authors.lastname: Bonney
authors.affiliation: Centre for Clinical Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Das-Gupta
authors.affiliation: Birmingham Childrens Hospital, Birmingham, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Lawson
authors.affiliation: University Hospitals Birmingham NHS Trust, Birmingham, UK.
authors.forename: Ram K
authors.initials: RK
authors.lastname: Malladi
authors.affiliation: Beatson West of Scotland Cancer Centre, Clinical Apheresis Unit.
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Douglas
authors.affiliation: Rotherham Foundation NHS Trust, Rotherham, UK.
authors.forename: Tracey
authors.initials: T
authors.lastname: Maher
authors.affiliation: Institute of Cellular Medicine, Newcastle University and Great North Children's Hospital, Newcastle-Upon-Tyne, UK.
authors.forename: Julie
authors.initials: J
authors.lastname: Guest
authors.affiliation: Birmingham Childrens Hospital, Birmingham, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Hartlett
authors.affiliation: Institute of Transplantation, Newcastle University and Freeman Hospital, Newcastle-upon-Tyne, UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Fisher
authors.affiliation: St John's Institute of Dermatology, Guy's and St Thomas' Hospital, London, UK.
authors.forename: Fiona
authors.initials: F
authors.lastname: Child
authors.affiliation: University Hospitals Birmingham NHS Trust, Birmingham, UK.
authors.forename: Julia J
authors.initials: JJ
authors.lastname: Scarisbrick
mesh_terms: D032921:Consensus; D006084:Graft Rejection / Q000628:therapy*; D006086:Graft vs Host Disease / Q000628:therapy*; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000628:therapy*; D017893:Photopheresis / Q000379:methods*; D006113:United Kingdom
keywords: cutaneous T-cell lymphoma; extracorporeal photopheresis; graft-versus-host disease; rejection; treatment protocol