title: Relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly Chinese population.
abstract: Objective To investigate the relationship between hyperuricemia and coronary heart disease (CHD) risk based on the Framingham risk score (FRS) in a middle-aged and elderly Chinese population. Methods This cross-sectional study enrolled patients undergoing routine check-ups at Xiangya Hospital between October 2013 and November 2014. Hyperuricemia was defined as uric acid ≥416 mmol/l for males and ≥360 mmol/l for females. A 10-year CHD risk was calculated from FRS. A multivariable logistic analysis model was used to evaluate associations. Results Of the 6347 patients, 3415 (53.8%) were male, 1543 (24.3%) had a CHD risk ≥10% (i.e. intermediate and high risk) and the prevalence of hyperuricemia was 18.1% ( n = 1148). After adjusting for potential confounding factors, the 10-year CHD risk was increased in patients with hyperuricemia compared with those without hyperuricemia by 0.28 times in the total population (odds ratio [OR] 1.28; 95% confidence interval [CI] 1.09, 1.48), by 0.25 times in the male population (OR 1.25; 95% CI 1.06, 1.47) and by 2.76 times in the female population (OR 3.76; 95% CI 2.08, 6.79). Conclusion Hyperuricemia was positively associated with a 10-year risk of CHD suggesting that it might be an independent CHD risk factor in middle-aged and elderly individuals.
authors.affiliation: 1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Yang
authors.affiliation: 1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Tian
authors.affiliation: 1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zeng
authors.affiliation: 2 Health Management Centre, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.|3 Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.affiliation: 1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Liang-Jun
authors.initials: LJ
authors.lastname: Li
authors.affiliation: 1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Xie
authors.affiliation: 1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Tuo
authors.initials: T
authors.lastname: Yang
authors.affiliation: 1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: 1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Guang-Hua
authors.initials: GH
authors.lastname: Lei
mesh_terms: D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D003327:Coronary Disease / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000208:ethnology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000208:ethnology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012306:Risk; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid
keywords: Framingham risk score; Hyperuricemia; coronary heart disease risk