title: Bifidobacterium bifidum OLB6378 Simultaneously Enhances Systemic and Mucosal Humoral Immunity in Low Birth Weight Infants: A Non-Randomized Study.
abstract: Probiotic supplementation has been part of the discussion on methods to enhance humoral immunity. Administration ofBifidobacterium bifidumOLB6378 (OLB6378) reduced the incidence of late-onset sepsis in infants. In this non-randomized study, we aimed to determine the effect of administration of live OLB6378 on infants' humoral immunity. Secondly, we tried to elucidate whether similar effects would be observed with administration of non-live OLB6378. Low birth weight (LBW) infants weighing 1500-2500 g were divided into three groups: Group N (no intervention), Group L (administered live OLB6378 concentrate), and Group H (administered non-live OLB6378 concentrate). The interventions were started within 48 h after birth and continued until six months of age. Serum immunoglobulin G (IgG) levels (IgG at one month/IgG at birth) were significantly higher in Group L than in Group N (p< 0.01). Group H exhibited significantly higher serum IgG levels (p< 0.01) at one month of age and significantly higher intestinal secretory immunoglobulin A (SIgA) levels (p< 0.05) at one and two months of age than Group N. No difference was observed in the mortality or morbidity between groups. Thus, OLB6378 administration in LBW infants enhanced humoral immunity, and non-live OLB6378, which is more useful as a food ingredient, showed a more marked effect than the viable bacteria.
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. tanakatsu0124@gmail.com.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Laboratory of Animal Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Hangi-cho, Shimogamo, Sakyo-ku, Kyoto 606-8522, Japan. tsukahara@kpu.ac.jp.
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Tsukahara
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. tyanagi@belle.shiga-med.ac.jp.
authors.forename: Takahide
authors.initials: T
authors.lastname: Yanagi
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. sayuri10@belle.shiga-med.ac.jp.
authors.forename: Sayuri
authors.initials: S
authors.lastname: Nakahara
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. ouki@belle.shiga-med.ac.jp.
authors.forename: Ouki
authors.initials: O
authors.lastname: Furukawa
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. hidemizura@yahoo.co.jp.
authors.forename: Hidemi
authors.initials: H
authors.lastname: Tsutsui
authors.affiliation: Department of Community Perinatal Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. koshida@belle.shiga-med.ac.jp.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Koshida
mesh_terms: D000069985:Bifidobacterium bifidum; D005260:Female; D006801:Humans; D056724:Immunity, Humoral; D018928:Immunity, Mucosal; D007074:Immunoglobulin G / Q000097:blood; D015994:Incidence; D007223:Infant; D007230:Infant, Low Birth Weight / Q000276:immunology*; D008297:Male; D065228:Non-Randomized Controlled Trials as Topic; D019936:Probiotics / Q000008:administration & dosage*; D018805:Sepsis / Q000517:prevention & control*; D013048:Specimen Handling; D016896:Treatment Outcome
chemical_list: D007074:Immunoglobulin G
keywords: heat-treated; humoral immunity; non-live bacteria; probiotics; sepsis; serum IgG; stool secretory IgA