title: Preparation of Chitosan-Coated Nanostructured Lipid Carriers (CH-NLCs) to Control Iron Delivery and Their Potential Application to Food Beverage System.
abstract: Nanostructured lipid carriers (NLCs) and chitosan-coated NLCs (CH-NLCs) were prepared by a combined double emulsion and melt dispersion method. The physicochemical properties of them were investigated to determine the optimum conditions. At 3% emulsifier concentration, the NLCs showed about 191.0 ± 4.1 nm mean particle size and low polydispersity index value compared to those observed under other conditions. The encapsulation efficiency of CH-NLCs was 83.9% which was about 10% higher than that of NLCs. In vitro release test showed that low release amount of iron from the NLCs (11%) and CH-NLCs (5%) in simulated gastric condition within 3 h, whereas the iron release amounts of the NLCs and CH-NLCs were high (over 77%) in simulated intestinal condition because both NLCs and CH-NLCs were totally destructed in the intestinal condition after 3 h. In the thiobarbituric acid test, the absorbance of milk-fortified NLC and CH-NLCs was lower than that of original milk. Based on these results, CH-NLCs showed great potential for iron fortification in milk.
authors.affiliation: College of Life Sciences & Biotechnology, Korea Univ., Anam-dong, Sungbuk-gu, Seoul, 02861, Korea.
authors.forename: Sun Ah
authors.initials: SA
authors.lastname: Lee
authors.affiliation: College of Life Sciences & Biotechnology, Korea Univ., Anam-dong, Sungbuk-gu, Seoul, 02861, Korea.
authors.forename: Hee Joung
authors.initials: HJ
authors.lastname: Joung
authors.affiliation: College of Life Sciences & Biotechnology, Korea Univ., Anam-dong, Sungbuk-gu, Seoul, 02861, Korea.
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Dept. of Food & Nutrition, Kunsan Natl. Univ., Gunsan, 54150, Korea.
authors.forename: Gye Hwa
authors.initials: GH
authors.lastname: Shin
mesh_terms: D001628:Beverages; D048271:Chitosan / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004041:Dietary Fats / Q000032:analysis; D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions; D007501:Iron / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size
chemical_list: D020099:Coated Materials, Biocompatible; D004041:Dietary Fats; D004337:Drug Carriers; D004655:Emulsions; D048271:Chitosan; D007501:Iron
keywords: chitosan; ferric pyrophosphate (FePP); iron fortification; nanostructured lipid carriers (NLCs); palm oil