title: Expression of Stromal Caveolin- 1 May Be a Predictor for Aggressive Behaviour of Breast Cancer.
abstract: Caveolin-1 (Cav-1) is well known as a principal scaffolding protein of caveolae which are specialized plasma membrane structures. The role of Cav-1 in tumorigenesis of breast cancers is relatively less studied. The aim of the present study is to describe the biological roles of Cav-1 in breast cancers considering its contrasting dual functions as an oncogene and as a tumor suppressor. This study included 71 females with breast cancer who had been histopathologically diagnosed in Private Gunes Pathology Laboratory between the years 2007, and 2012. The mean age is 52.48 ± 12.8 years. Patients were followed up for a mean period of 47.97 ± 20.48 months. We didn't determine Cav-1 positive tumor cells. In 36 cases (50.7%), there were stromal expressions of Cav-1. In the statistical analysis, there was a statistically significant correlation between Cav-1 expression and ER (p = 0.033), metastasis (p = 0.005), lymphatic invasion (p = 0.000), nodal metastasis (p = 0,003), perinodal invasion (p = 0.003), metastasis (p = 0.005) and survival (p = 0.009). We found that Cav-1 expression is associated with tumor size, histological grade, lymph node involvement. Accordingly, we have suggested that Cav-1 may be a predictive biomarker for breast cancer.
authors.affiliation: Pathology Department, Adnan Menderes University Medical Faculty, Aydin, Turkey.
authors.forename: Nuket
authors.initials: N
authors.lastname: Eliyatkin
authors.affiliation: Basic Oncology Department, Dokuz Eylul University Oncology Institute, Izmir, Turkey.
authors.forename: Safiye
authors.initials: S
authors.lastname: Aktas
authors.affiliation: Pathology Department, Tepecik Education and Research Hospital, Kibris Sehitleri Cad 51/11 Alsancak, 35220, Izmir, Turkey. agdiniz@gmail.com.
authors.forename: Gulden
authors.initials: G
authors.lastname: Diniz
authors.affiliation: Private Gunes Pathology Laboratory, Izmir, Turkey.
authors.forename: Halil Hakan
authors.initials: HH
authors.lastname: Ozgur
authors.affiliation: Pathology Department, Tepecik Education and Research Hospital, Kibris Sehitleri Cad 51/11 Alsancak, 35220, Izmir, Turkey.
authors.forename: Zubeyde Yildirim
authors.initials: ZY
authors.lastname: Ekin
authors.affiliation: Private Gunes Pathology Laboratory, Izmir, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Kupelioglu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000556:secondary*; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000556:secondary*; D051242:Caveolin 1 / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology*; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C495540:CAV1 protein, human; D051242:Caveolin 1
keywords: Breast cancer; Caveolin 1; Predictive biomarker