title: No impact of eight NTRK2 genetic polymorphisms on 6-month antidepressant efficacy in depressed patients.
abstract: OBJECTIVE
  NTRK2 is the main receptor of the brain derived neurotrophic factor, which is involved in antidepressant efficacy. We assessed the impact of eight NTRK2 SNPs pertaining to response and remission after antidepressant treatment in depressed patients.
  
  
  METHODS
  In a naturalistic study, 569 patients with a major depressive episode requiring a new antidepressant treatment were genotyped for eight NTRK2 SNPs (rs1187352, rs1439050, rs1778933 rs2289656, rs2289657, rs2289658, rs3824519, rs56142442) and prospectively assessed for response and remission after 6 months of treatment.
  
  
  RESULTS
  No association was shown between the NTRK2 SNPs and response/remission.
  
  
  CONCLUSIONS
  There is no benefit to assess these eight TRKB SNPs to predict response/remission after antidepressant treatment in depressed patients.
authors.affiliation: INSERM UMR_S1178, Equipe 'Dépression et Antidépresseurs', Univ. Paris-Sud, Faculté de Médecine, CESP, Le Kremlin Bicêtre, France.|Département de Médecine Générale, Univ. Paris-Sud, Faculté de Médecine, Le Kremlin Bicêtre, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Deflesselle
authors.affiliation: INSERM UMR 1184, Univ. Paris-Sud, Le Kremlin-Bicêtre, France.|CEA, DSV/iMETI, IDMIT, Fontenay-aux-Roses, France.|INSERM, U1184, Immunologie des infections virales et des maladies auto-immunes, Le Kremlin-Bicêtre, France, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre.|Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France.|Centre de Ressources Biologiques Paris Sud, Hôpital Bicêtre, Assistance Publique - Hôpitaux de Paris, Le Kremlin Bicêtre, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Verstuyft
authors.affiliation: INSERM UMR_S1178, Equipe 'Dépression et Antidépresseurs', Univ. Paris-Sud, Faculté de Médecine, CESP, Le Kremlin Bicêtre, France.|Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique - Hôpitaux de Paris, Le Kremlin Bicêtre, France.
authors.forename: Anne-Cécile
authors.initials: AC
authors.lastname: Petit
authors.affiliation: INSERM UMR_S1178, Equipe 'Dépression et Antidépresseurs', Univ. Paris-Sud, Faculté de Médecine, CESP, Le Kremlin Bicêtre, France.|Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique - Hôpitaux de Paris, Le Kremlin Bicêtre, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Hardy
authors.affiliation: INSERM UMR_S1178, Equipe "Dépression et Antidépresseurs", Univ. Paris-Saclay, Univ. Paris-Sud, Faculté de Pharmacie, CESP, Chatenay-Malabry 92296, France.
authors.forename: Denis J
authors.initials: DJ
authors.lastname: David
authors.affiliation: INSERM UMR_S1178, CESP, Département de Biostatistiques, Univ. Paris-Sud, Hôpital Paul Brousse, Assistance Publique Hôpitaux de Paris, 94400 Villejuif, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Falissard
authors.affiliation: INSERM UMR_S938, Sorbonne Universités, Univ. Pierre et Marie Curie, Centre de Recherche Saint-Antoine, Institut Hospitalo-Universitaire ICAN, Paris, France.|Service d'Endocrinologie, Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris, Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Fève
authors.affiliation: Département de Médecine Générale, Univ. Paris-Sud, Faculté de Médecine, Le Kremlin Bicêtre, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Rigal
authors.affiliation: INSERM UMR 1184, Univ. Paris-Sud, Le Kremlin-Bicêtre, France.|CEA, DSV/iMETI, IDMIT, Fontenay-aux-Roses, France.|INSERM, U1184, Immunologie des infections virales et des maladies auto-immunes, Le Kremlin-Bicêtre, France, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre.|Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France.|Centre de Ressources Biologiques Paris Sud, Hôpital Bicêtre, Assistance Publique - Hôpitaux de Paris, Le Kremlin Bicêtre, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Becquemont
authors.affiliation: INSERM UMR_S1178, Equipe 'Dépression et Antidépresseurs', Univ. Paris-Sud, Faculté de Médecine, CESP, Le Kremlin Bicêtre, France.|Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique - Hôpitaux de Paris, Le Kremlin Bicêtre, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Corruble
authors.affiliation: INSERM UMR_S1178, Equipe 'Dépression et Antidépresseurs', Univ. Paris-Sud, Faculté de Médecine, CESP, Le Kremlin Bicêtre, France.|Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique - Hôpitaux de Paris, Le Kremlin Bicêtre, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Colle
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D020813:Receptor, trkB; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D008562:Membrane Glycoproteins; D011505:Protein-Tyrosine Kinases; D020813:Receptor, trkB; C000591259:tropomyosin-related kinase-B, human
keywords: NTRK2; TRKB; antidepressant; genetic polymorphism; major depressive disorder; major depressive episode; pharmacogenetics; remission; response