title: Comparison of Post-Liver Transplantation Outcomes in Portopulmonary Hypertension and Pulmonary Venous Hypertension: A Single-Center Experience.
abstract: BACKGROUND
  In potential liver transplant candidates, pulmonary vascular diseases, including portopulmonary hypertension (PoPH) and pulmonary venous hypertension (PVH), can be associated with high morbidity and mortality. Although there are clear guidelines regarding management and transplant listing criteria for patients with PoPH, the listing criteria for PVH are not well defined.
  
  
  OBJECTIVE
  The aim of this study was to describe and compare the perioperative and postoperative morbidity and mortality associated with PoPH and PVH in patients undergoing liver transplantation.
  
  
  METHODS
  We conducted a retrospective observational study of all patients referred for liver transplantation to our center between 2005 and 2015 who underwent a right heart catheterization (RHC) for screening for pulmonary hypertension as suggested by initial echocardiography. Based on the RHC data, the patients were grouped into no pulmonary hypertension (No PH), PoPH, and PVH categories. In patients who underwent liver transplantation, we recorded vital status intraoperatively and at 30 days and 1-year post-transplant, and we recorded the incidence of postoperative cardiopulmonary and renal complications.
  
  
  RESULTS
  Of the 134 patients who underwent RHC as part of the initial transplant evaluation, 50 patients were successfully transplanted. There was 1 intraoperative death in the PoPH group. No significant difference in mortality was noted between the No PH, PoPH, and PVH groups intraoperatively and 30 days after liver transplantation. At 1 year, the survival rates were 100%, 69.2%, and 94.1% in the No PH, PoPH, and PVH groups, respectively. With respect to cardiopulmonary and renal complications, no statistically significant difference was noted among the groups, though there was a trend toward increased post-transplant reversible pulmonary complications in the PVH group.
  
  
  CONCLUSIONS
  Our findings suggest that the post-transplant outcomes of patients with PoPH and PVH are similar. In light of the growing recognition of diastolic dysfunction and cirrhotic cardiomyopathy in decompensated cirrhotic patients at the time of transplant, the issue of pulmonary hypertension related to PVH will gain increasing importance as we assess these patients for transplantation. Therefore, future studies are needed to define evidence based guidelines to determine candidacy for liver transplantation in the context of PVH.
authors.affiliation: Emory University School of Medicine, Department of Medicine, Atlanta, Georgia, USA.
authors.forename: P
authors.initials: P
authors.lastname: Rajaram
authors.affiliation: Emory University School of Medicine, Department of Medicine, Atlanta, Georgia, USA.
authors.forename: A
authors.initials: A
authors.lastname: Parekh
authors.affiliation: Emory University School of Medicine, Department of Medicine, Atlanta, Georgia, USA.
authors.forename: M
authors.initials: M
authors.lastname: Fisher
authors.affiliation: Emory University School of Medicine, Department of Medicine, Atlanta, Georgia, USA.
authors.forename: J
authors.initials: J
authors.lastname: Kempker
authors.affiliation: Emory University School of Medicine, Department of Medicine, Atlanta, Georgia, USA. Electronic address: rmsubra@emory.edu.
authors.forename: R
authors.initials: R
authors.lastname: Subramanian
mesh_terms: D006328:Cardiac Catheterization / Q000379:methods; D004452:Echocardiography / Q000009:adverse effects; D058625:End Stage Liver Disease / Q000401:mortality / Q000601:surgery; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D006976:Hypertension, Pulmonary / Q000150:complications*; D016031:Liver Transplantation / Q000009:adverse effects / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D011652:Pulmonary Circulation / Q000502:physiology; D012189:Retrospective Studies