title: Extracellular vesicles: An overview of biogenesis, function, and role in breast cancer.
abstract: Extracellular vesicles have emerged as important mediators of intercellular communication and play an active role in cancer, including breast cancer. Despite limited studies, initial observations suggest that these vesicles are important in breast physiology and pathophysiology. We here, in brief, describe their potential use as future biomarkers and therapeutic agents in breast cancer. Extracellular vesicles in blood and breast fluid may have a great potential to detect and predict the presence of breast cancer, and extracellular vesicles modulation may emerge as a therapeutic approach in cancer therapy.
authors.affiliation: 1 Department of Oncology, Jintan Hospital Affiliated to Jiangsu University, Jintan, China.
authors.forename: Quan Bin
authors.initials: QB
authors.lastname: Zha
authors.affiliation: 2 Department of General Surgery, Jiangsu Cancer Hospital, Nanjing, China.
authors.forename: Yu Feng
authors.initials: YF
authors.lastname: Yao
authors.affiliation: 3 Department of Pathology, Jiangsu Cancer Hospital, Nanjing, China.
authors.forename: Zhao Jun
authors.initials: ZJ
authors.lastname: Ren
authors.affiliation: 2 Department of General Surgery, Jiangsu Cancer Hospital, Nanjing, China.|4 The First School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
authors.forename: Xiu Juan
authors.initials: XJ
authors.lastname: Li
authors.affiliation: 2 Department of General Surgery, Jiangsu Cancer Hospital, Nanjing, China.|4 The First School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
authors.forename: Jin Hai
authors.initials: JH
authors.lastname: Tang
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D045744:Cell Line, Tumor; D000067128:Extracellular Vesicles / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D061986:MCF-7 Cells
chemical_list: D014408:Biomarkers, Tumor
keywords: Extracellular vesicles; breast cancer; exosomes; microvesicles; review