title: Mir-20b-Induced Increase in Myeloid-Derived Suppressor Cells in the Lungs of Mice with Chronic Asthma.
abstract: Bronchial asthma is a common chronic airway inflammatory disease. MicroRNAs (miRNAs) play an important role in the pathogenesis of asthma. We have previously shown that miR-20b can inhibit airway inflammation in asthmatic mice, but the exact mechanism is unknown. In the present study, we show that administration of nasal drops containing miR-20b induced an increase in the percentage of Gr1+CD11b+myeloid-derived suppressor cells (MDSCs) in lung tissue from asthmatic mice, and the content of TGF-β in lung tissues also increased after treatment. However, there was no significant change in the number of Gr1+CD11b+MDSCs in bone marrow, peripheral blood, or spleens of asthmatic mice receiving the miR-20b nasal drip compared with untreated asthmatic mice. Since MDSCs originate in the bone marrow, these results suggest that miR-20b nasal drops may promote the increase of Gr1+CD11b+MDSCs in the lungs of asthmatic mice by the mechanism of inducing expansion.
authors.affiliation: Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, China.
authors.forename: Helong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, China.
authors.forename: Yulan
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, China.
authors.forename: Shujun
authors.initials: S
authors.lastname: Guo
authors.affiliation: Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui, China chuanwangsong@163.com.
authors.forename: Chuanwang
authors.initials: C
authors.lastname: Song
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D001249:Asthma / Q000097:blood / Q000473:pathology; D001853:Bone Marrow / Q000378:metabolism; D039481:CD11b Antigen / Q000378:metabolism; D002452:Cell Count; D002645:Chickens; D002908:Chronic Disease; D008168:Lung / Q000378:metabolism* / Q000473:pathology*; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000378:metabolism*; D000072737:Myeloid-Derived Suppressor Cells / Q000378:metabolism*; D013154:Spleen / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D039481:CD11b Antigen; D035683:MicroRNAs; C532375:Mirn20 microRNA, mouse; D016212:Transforming Growth Factor beta
keywords: asthma; miR-20b; myeloid-derived suppressor cells