title: Investigation of Factors Affecting Aerodynamic Performance of Nebulized Nanoemulsion.
abstract: This work aimed to prepare a nanoemulsion preparation containing budesonide and assess its aerodynamic behavior in comparison with suspension of budesonide.In-vitroaerodynamic performance of the corresponding micellar solution (ie. nanoemulsion preparation without oil) was investigated too. Nanoemulsions of almond oil containing budesonide, as a hydrophobic model drug molecule, were prepared and optimized. Then, the effect of variation of surfactant/co-surfactant concentration on the aerodynamic properties of the nebulized aerosol was studied. The results indicated that the most physically stable formulation makes the smallest aerodynamic size. The concentration of co-surfactant was also shown to be critical in determination of aerodynamic size. Furthermore, the optimized sample, with 3% w/w almond oil, 20% w/w Tween 80+Span 80 and 2% w/w ethanol showed a smaller MMAD in comparison with the commercially available suspension and the micellar solution.
authors.affiliation: Targeted Drug Delivery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Research Center of Natural Product Safety and Medicinal Plants, North Khorasan University of Medical Sciences, Bojnurd , Iran.
authors.forename: Hosein
authors.initials: H
authors.lastname: Kamali
authors.affiliation: Institute of Biochemistry and Biophysics (I.B.B), University of Tehran, Tehran, Iran.
authors.forename: Shayan
authors.initials: S
authors.lastname: Abbasi
authors.affiliation: Department of Microbiology, Faculty of Veterinary Medicine, Islamic Azad University, Karaj branch, Karaj, Iran .
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Amini
authors.affiliation: Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. ; Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Amani
keywords: Budesonide; Micelle; Nanoemulsion; Nebulizer