title: Neuroprotective Properties ofPanax notoginsengSaponins via Preventing Oxidative Stress Injury in SAMP8 Mice.
abstract: Inhibiting oxidative damage in early stage of Alzheimer's disease (AD) is considered as a strategy for AD treatment. Our previous study has shown thatPanax notoginsengsaponins (PNS) have an antiaging action by increasing the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) in the serum of aged rats. In this study, we aimed to investigate the effects of PNS on antioxidant enzymes and uncoupling proteins (UCPs) involved in oxidative stress in AD mice. The results showed that PNS prevented neuronal loss in hippocampal CA1 region and alleviated pathomorphological change of neurons in CA1 region. Moreover, PNS inhibited the production of 8-hydroxydeoxyguanosine (8-OHdG), enhanced the expressions and activities of SOD, CAT, and GSH-PX, and improved the mRNA and protein levels of UCP4 and UCP5 in the brains of SAMP8 mice. Together, our study shows that PNS has the ability to protect neurons in AD brain from oxidative stress damage through attenuating the production of 8-OHdG, enhancing the activities of antioxidant enzymes and the expressions levels of UCP4 and UCP5. Accordingly, PNS may be a promising agent for AD treatment.
authors.affiliation: Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Pharmacy School, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Department of Pharmacology, Pharmacy School, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
authors.forename: Jin-Lan
authors.identifier: 0000-0002-1370-2381
authors.initials: JL
authors.lastname: Huang
authors.affiliation: Department of Pharmacology, Xi'an Medical College, Xi'an, Shangxi 710309, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jing
authors.affiliation: Guangxi Adverse Drug Reaction Monitoring Center, Nanning, Guangxi 530029, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Science and Technology, Guangxi University of Chinese Medicine, Nanning, Guangxi 530200, China.
authors.forename: Mei-Chun
authors.initials: MC
authors.lastname: Qin
authors.affiliation: Department of Science and Technology, Guangxi University of Chinese Medicine, Nanning, Guangxi 530200, China.
authors.forename: Zhe-Hao
authors.initials: ZH
authors.lastname: Xu
authors.affiliation: Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Pharmacy School, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Department of Pharmacology, Pharmacy School, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
authors.forename: Deng-Pan
authors.identifier: 0000-0003-2739-601X
authors.initials: DP
authors.lastname: Wu
authors.affiliation: Department of Science and Technology, Guangxi University of Chinese Medicine, Nanning, Guangxi 530200, China.
authors.forename: Zhen-Guo
authors.identifier: 0000-0001-9598-2462
authors.initials: ZG
authors.lastname: Zhong