title: [Precision first-line therapy for advanced non-small-cell lung cancer patients harboring EGFR mutation].
abstract: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have become the preferred treatment option for advanced non-small-cell lung cancer (NSCLC) patients with activating mutations in epidermal growth factor receptor (EGFR) according to major practice guidelines. Gefitinib, elortinib and icotinib formed the cornerstone of first-line EGFR-TKIs in the clinical practice in our country. Now, with the continuously emerging of new types of EGFR-TKIs and ever-increasing publication of clinical trial results on afatinib, AZD9291 and other TKIs, we have more first-line choices for patients with EGFR mutations. Meanwhile, the development of gene detection technology is facilitating investigators to get insights on the molecular biological behavior of NSCLC and to elucidate the mechanism of drug resistance. This review will focus on precision first-line therapy for advanced NSCLC patients harboring EGFR mutation.
authors.affiliation: Department of Respiratory Medicine, Jinling Hospital, Nanjing University Institute of Respiratory Medicine, Nanjing 210002, China.
authors.forename: D M
authors.initials: DM
authors.lastname: Yuan
authors.affiliation: Department of Respiratory Medicine, Jinling Hospital, Nanjing University Institute of Respiratory Medicine, Nanjing 210002, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Song
mesh_terms: D000077716:Afatinib; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics; D043844:Crown Ethers / Q000627:therapeutic use; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000235:genetics; D000077156:Gefitinib; D018773:Genes, erbB-1; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics; D009154:Mutation; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D043844:Crown Ethers; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000077716:Afatinib; C531470:icotinib; C512478:EGFR protein, human; D066246:ErbB Receptors; D000077156:Gefitinib
keywords: Cancer, non-small-cell lung; Epidermal growth factor receptor; First-line therapy; Precision therapy; Tyrosine kinase inhibitor