title: Toxic epidermal necrolysis in a child with lupus-associated pancreatitis.
abstract: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening dermatological conditions that are characterized by mucosal erosions, epidermal detachments and erosions. The most common causes of SJS and TEN are drugs; other causes such as systemic lupus erythematosus (SLE), vaccinations and infections have been rarely implicated. We present the case of a 14-year-old female patient with acute pancreatitis as an initial manifestation of systemic lupus erythematosus, complicated by the toxic epidermal necrolysis with a fatal outcome. She initially presented with abdominal pain, fever, vomiting, and intolerance to oral intake and elevated pancreatic enzyme levels. Systemic lupus erythematosus was diagnosed secondary when her condition has been already complicated by the toxic epidermal necrolysis. The administration of corticosteroids and high doses of intravenous immunoglobulin did not lead to positive effects in the treatment of our patient.
authors.affiliation: Department of Anesthesia, Faculty of Medicine, University of Belgrade, Tirsova 10, Belgrade, Serbia. mamarija74@gmail.com.
authors.forename: Stevic
authors.initials: S
authors.lastname: Marija
authors.affiliation: Department of Anesthesia, Faculty of Medicine, Clinical Centre Nis, University of Nis, Bulevar dr Zorana Djindjica 81, Nis, Serbia.
authors.forename: Budic
authors.initials: B
authors.lastname: Ivana
authors.affiliation: Department of Gastroenterology, University Children's Hospital, Svetogorska 11, Belgrade, Serbia.
authors.forename: Ristic
authors.initials: R
authors.lastname: Nina
authors.affiliation: Department of Anesthesia, Royal Victoria Hospital, 274 Grosnor RD, Belfast, BT, 12 6BA, UK.
authors.forename: Nenadic
authors.initials: N
authors.lastname: Dragan
authors.affiliation: Department of Minimally Invasive Surgery, Zvezdara University Center, Dimitrija Tucovica 161, Belgrade, Serbia.
authors.forename: Bokun
authors.initials: B
authors.lastname: Zlatko
authors.affiliation: Department of Abdominal surgery, University Children's Hospital, Tirsova 10, Belgrade, Serbia.
authors.forename: Jovanovic
authors.initials: J
authors.lastname: Branislav
authors.affiliation: Department of Abdominal surgery, University Children's Hospital, Tirsova 10, Belgrade, Serbia.
authors.forename: Pejanovic
authors.initials: P
authors.lastname: Jelena
authors.affiliation: Department of Anesthesia, Faculty of Medicine, University of Belgrade, Tirsova 10, Belgrade, Serbia.
authors.forename: Simic
authors.initials: S
authors.lastname: Dusica
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D010195:Pancreatitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D012307:Risk Factors; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D017211:Treatment Failure
chemical_list: D000305:Adrenal Cortex Hormones; D016756:Immunoglobulins, Intravenous
keywords: Child; Lupus; Pancreatitis; Toxic epidermal necrolisis