title: Laboratory assessment of sudden sensorineural hearing loss: A case-control study.
abstract: Sudden sensorineural hearing loss (SSHL) is an otologic emergency that affects five to 30 subjects per 100,000/year. The cause of SSHL remains unknown or uncertain in 70% to 90% of cases, and treatment decisions are usually made without knowing the etiology.
  
  
  
  Prospective case-control study.
  
  
  
  One hundred thirty-one idiopathic SSHL patients were recruited from January 2014 to June 2015 in concordance with the Statements of Clinical Practice Guideline and divided into groups according to the disease severity. A clinical laboratory assessment was completed on blood samples collected from SSHL patients and control subjects. Multivariable regression analysis was performed to investigate the association between laboratory data and SSHL basis.
  
  
  
  Only a few SSHL patients were positive for autoimmunity or viral infection. Statistically significant (P < .05) higher levels of blood glucose, glycated hemoglobin (HbA1C), lipoprotein (a), and factor VIII were found in SSHL patients compared to controls. Furthermore, blood glucose, HbA1C, uric acid, factor VIII, and homocysteine were significantly associated to disease severity.
  
  
  
  Gluco-metabolic, lipidic, and coagulative laboratory data support the vascular hypothesis for SSHL and its severity.
  
  
  
  3b Laryngoscope, 127:2375-2381, 2017.
authors.affiliation: Clinical Chemistry and Endocrinology Laboratory, Arcispedale Santa Maria Nuova-Scientific Institute for Research, Hospitalization and Health Care, Reggio Emilia, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Fasano
authors.affiliation: Transfusion Medicine Unit, Arcispedale Santa Maria Nuova- Scientific Institute for Research, Hospitalization and Health Care, Reggio Emilia, Italy.|Department of Biomedical, Biotechnological, and Translational Sciences, University of Parma, Parma, Italy.
authors.forename: Thelma A
authors.initials: TA
authors.lastname: Pertinhez
authors.affiliation: Department of Otolaryngology and Audiology, Arcispedale Santa Maria Nuova-Scientific Institute for Research, Hospitalization and Health Care, Reggio Emilia, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Tribi
authors.affiliation: Transfusion Medicine Unit, Arcispedale Santa Maria Nuova- Scientific Institute for Research, Hospitalization and Health Care, Reggio Emilia, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Lasagni
authors.affiliation: Clinical Chemistry and Endocrinology Laboratory, Arcispedale Santa Maria Nuova-Scientific Institute for Research, Hospitalization and Health Care, Reggio Emilia, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Pilia
authors.affiliation: Clinical Chemistry and Endocrinology Laboratory, Arcispedale Santa Maria Nuova-Scientific Institute for Research, Hospitalization and Health Care, Reggio Emilia, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Vecchia
authors.affiliation: Transfusion Medicine Unit, Arcispedale Santa Maria Nuova- Scientific Institute for Research, Hospitalization and Health Care, Reggio Emilia, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Baricchi
authors.affiliation: Department of Otolaryngology and Audiology, Arcispedale Santa Maria Nuova-Scientific Institute for Research, Hospitalization and Health Care, Reggio Emilia, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Bianchin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001299:Audiometry; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000097:blood* / Q000175:diagnosis; D003639:Hearing Loss, Sudden / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Sudden sensorineural hearing loss; metabolic etiology; risk factors; vascular etiology