title: Association of vitamin D receptor polymorphisms and type 1 diabetes susceptibility in children: a meta-analysis.
abstract: BACKGROUND
  There have been studies focused onFokI,BsmI,ApaI andTaqI polymorphisms of the vitamin D receptor (VDR) gene and susceptibility to type 1 diabetes mellitus with controversial results.
  
  
  METHODS
  This present study is a meta-analysis investigating the association between FokI, ApaI, TaqI and BsmI polymorphisms of VDR gene and type 1 DM in children. A literature search was performed using Medline, EMBASE, Cochrane and PubMed. Any study was considered eligible for inclusion if at least one ofFokI,ApaI,TaqI andBsmI polymorphisms was determined, and outcome was type 1 DM at pediatric age.
  
  
  RESULTS
  A total of 9 studies comprising 1053 patients and 1017 controls met the study inclusion criteria. The pooled odds ratios (ORs) of theFokI,ApaI,TaqI andBsmI polymorphisms were combined and calculated. Forest plots and funnel plots of the OR value distributions were drawn. Our meta-analysis has demonstrated statistically significant associations between DM1 and VDR genotypes,BsmIBB (P< 0.05),BsmIBb, (P< 0.05),BsmIbb (P< 0.05),TaqITT (P< 0.05) andTaqItt (P< 0.05) in children.
  
  
  CONCLUSIONS
  The results indicated thatBsmIBB,BsmIBb andTaqItt polymorphisms were associated with an increased risk of type 1 DM, whereasBsmIbb andTaqITT had protective effect for type 1 DM in children.
authors.affiliation: Department of PediatricsAcıbadem University School of Medicine, Atasehir, Istanbul, Turkey ozlemnaciyeatansahin@yahoo.com.
authors.forename: Ozlem Atan
authors.initials: OA
authors.lastname: Sahin
authors.affiliation: Department of Pediatric EndocrinologyFaculty of Medicine, Ege University, Bornova, Izmir, Turkey.
authors.forename: Damla
authors.initials: D
authors.lastname: Goksen
authors.affiliation: Department of BiochemistryAcıbadem University, School of Medicine, Atasehir, Istanbul, Turkey.
authors.forename: Aysel
authors.initials: A
authors.lastname: Ozpinar
authors.affiliation: Department of BiochemistryAcıbadem University, School of Medicine, Atasehir, Istanbul, Turkey.
authors.forename: Muhittin
authors.initials: M
authors.lastname: Serdar
authors.affiliation: Department of Medical GeneticsFaculty of Medicine, Ege University, Bornova, Izmir, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Onay
keywords: VDR; diabetes mellitus; meta-analysis; polymorphisms