title: Weight loss in the early stage of progressive supranuclear palsy.
abstract: To clarify whether weight change in patients with Parkinson's disease (PD) or progressive supranuclear palsy (PSP) is caused by the disease itself or secondarily by other factors.
  
  
  
  We conducted a retrospective analysis of 51 patients with PD and 14 patients with PSP, especially during the early stage of their diseases. All patients were independent in terms of their activities of daily living and did not have any feeding difficulty.
  
  
  
  The body mass index measured within 3 years after the disease onset did not show a significant difference between the two diseases. However, the subsequent weight was stable in patients with PD and significantly decreased in patients with PSP.
  
  
  
  Weight loss begins in the early stage of PSP, whereas dopaminergic treatment may contribute to keep weight in the early stage of PD through reduction of energy expenditure and/or improvement in appetite.
authors.affiliation: Department of Neurology Kansai Medical University Hirakata Osaka Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Tsuge
authors.affiliation: Department of Neurology Kansai Medical University Hirakata Osaka Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kaneko
authors.affiliation: Department of Neurology Kansai Medical University Hirakata Osaka Japan.
authors.forename: Reika
authors.initials: R
authors.lastname: Wate
authors.affiliation: Department of Neurology Kansai Medical University Hirakata Osaka Japan.
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Oki
authors.affiliation: Department of Neurology Kansai Medical University Hirakata Osaka Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Nagashima
authors.affiliation: Department of Neurology Kansai Medical University Hirakata Osaka Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Asayama
authors.affiliation: Department of Neurology Kansai Medical University Hirakata Osaka Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Department of Neurology Kansai Medical University Hirakata Osaka Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Fujita
authors.affiliation: Department of Neurology Kansai Medical University Hirakata Osaka Japan.
authors.forename: Akemi
authors.initials: A
authors.lastname: Saito
authors.affiliation: Department of Microbiology Kansai Medical University Hirakata Osaka Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Takenouchi
authors.affiliation: Department of Neurology Kansai Medical University Hirakata Osaka Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kusaka
mesh_terms: D000368:Aged; D015992:Body Mass Index; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D012189:Retrospective Studies; D013494:Supranuclear Palsy, Progressive / Q000503:physiopathology*; D015431:Weight Loss / Q000502:physiology*
keywords: Parkinson's disease; movement disorders; neurodegenerative disorders; progressive supranuclear palsy