title: Focus Issue: Autophagy as hero and villain.
abstract: This Focus Issue explores autophagic responses to stress in cardiometabolic disease, reveals how autophagy limits pathological hypertrophy in the heart, and describes how autophagy itself can regulate transcriptional responses to stress.
authors.affiliation: Science Signaling, AAAS, Washington, DC 20005, USA. wwong@aaas.org.
authors.forename: Wei
authors.initials: W
authors.lastname: Wong