title: New gonadotropin-releasing hormone glycolipids with direct antiproliferative activity and gonadotropin-releasing potency.
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia. Electronic address: pegah.varamini@sydney.edu.au.
authors.forename: Pegah
authors.initials: P
authors.lastname: Varamini
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
authors.forename: Friederike M
authors.initials: FM
authors.lastname: Mansfeld
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
authors.forename: Ashwini Kumar
authors.initials: AK
authors.lastname: Giddam
authors.affiliation: The University of Queensland Centre for Clinical Research and the School of Biomedical Sciences, Brisbane, Australia.
authors.forename: Frederik
authors.initials: F
authors.lastname: Steyn
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia; School of Pharmacy, The University of Queensland, Brisbane, Australia; Institute for Molecular Biosciences, The University of Queensland, Brisbane, Australia.
authors.forename: Istvan
authors.initials: I
authors.lastname: Toth
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry / Q000494:pharmacology*; D018938:Caco-2 Cells; D045744:Cell Line, Tumor; D005260:Female; D006017:Glycolipids / Q000737:chemistry*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D006062:Gonadotropins / Q000378:metabolism; D006801:Humans; D008297:Male; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology; D010902:Pituitary Gland / Q000166:cytology; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology; D051381:Rats; D017329:Triptorelin Pamoate / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D006017:Glycolipids; D006062:Gonadotropins; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone
keywords: Antitumor GnRH analogs; Cancer therapy; Glycolipid; Hormone-refractory prostate cancer; Peptide delivery; Reproductive cancer