title: Application of Hydrogel Template Strategy in Ocular Drug Delivery.
abstract: The hydrogel template strategy was previously developed to fabricate homogeneous polymeric microparticles. Here, we demonstrate the versatility of the hydrogel template strategy for the development of nanowafer-based ocular drug delivery systems. We describe the fabrication of dexamethasone-loaded nanowafers using polyvinyl alcohol and the instillation of a nanowafer on a mouse eye. The nanowafer, a small circular disk, is placed on the ocular surface, and it releases a drug as it slowly dissolves over time, thus increasing ocular bioavailability and enhancing efficiency to treat eye injuries.
authors.affiliation: Ocular Nanomedicine Research Laboratory, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, 77030, USA.
authors.forename: Crystal S
authors.initials: CS
authors.lastname: Shin
authors.affiliation: Ocular Nanomedicine Research Laboratory, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, 77030, USA.
authors.forename: Daniela C
authors.initials: DC
authors.lastname: Marcano
authors.affiliation: Industrial and Physical Pharmacy and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47906, USA.
authors.forename: Kinam
authors.initials: K
authors.lastname: Park
authors.affiliation: Ocular Nanomedicine Research Laboratory, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, 77030, USA. gacharya@bcm.edu.
authors.forename: Ghanashyam
authors.initials: G
authors.lastname: Acharya
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D003315:Cornea / Q000187:drug effects; D003907:Dexamethasone / Q000008:administration & dosage; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D016503:Drug Delivery Systems; D005123:Eye / Q000187:drug effects*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D051379:Mice; D011108:Polymers / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D011108:Polymers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D003907:Dexamethasone; D011142:Polyvinyl Alcohol
keywords: Cornea; Dexamethasone; Drug delivery; Eye; Hydrogel; Nanowafer