title: Cerebrospinal fluid neuron specific enolase, interleukin-1β and erythropoietin concentrations in children after seizures.
abstract: OBJECTIVE
  In the present study, the levels of neuron-specific enolase (NSE), interleukin-1β (IL-1β), and erythropoietin (EPO) in cerebrospinal fluid (CSF) in children with idiopathic epilepsy were measured to illuminate the relationships between these markers with idiopathic epilepsy.
  
  
  METHODS
  Eighty-five children from 6 months to 12.5 years of age with single, previously undiagnosed, and untreated idiopathic epilepsy were participated in this study. The concentrations of CSF NSE, 1L-1β, and EPO were measured by specific ELISA methods.
  
  
  RESULTS
  The mean concentrations of CSF NSE, IL-1β, and EPO in the epileptic groups showed a significant increase (P < 0.01) compared with those in the control groups. Besides, the mutual correlations of NSE, 1L-1β, and EPO were also analyzed. Results showed that there were positive correlations between the levels of IL-1β, NSE, and EPO.
  
  
  CONCLUSIONS
  The changes of NSE, 1L-1β, and EPO level in CSF may be beneficial for the pathophysiology study of epileptic seizures and the identification and diagnosis of a seizure clinically.
authors.affiliation: Department of Pediatric Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
authors.forename: Ling-Min
authors.initials: LM
authors.lastname: Shi
authors.affiliation: Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
authors.forename: Rui-Jie
authors.initials: RJ
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, 301103, Zhejiang, People's Republic of China.
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Jiang
authors.affiliation: Department of Pediatric Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China. a511511@163.com.|Medical Laboratory Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China. a511511@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Gong
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004921:Erythropoietin / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007223:Infant; D053583:Interleukin-1beta / Q000134:cerebrospinal fluid*; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid*; D012640:Seizures / Q000134:cerebrospinal fluid* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D053583:Interleukin-1beta; D004921:Erythropoietin; D010751:Phosphopyruvate Hydratase
keywords: Cerebrospinal fluid; Epilepsy; Erythropoietin; Interleukin-1β; Neuron-specific enolase