title: Retrobulbar ocular blood flow changes measured by colour Doppler imaging after intra-arterial chemotherapy in retinoblastoma.
abstract: To evaluate the effects of intra-arterial chemotherapy on retrobulbar blood ﬂow parameters in patients with retinoblastoma.
  
  
  
  20 eyes of 10 patients with unilateral retinoblastoma that were treated with intra-arterial chemotherapy were evaluated using colour Doppler imaging. The peak systolic and end-diastolic velocities of the ophthalmic, central retinal and posterior ciliary arteries were determined. The pulsatility and resistance indices were calculated automatically. The treated eye was compared with the untreated (control) eye and with itself before and after intra-arterial chemotherapy.
  
  
  
  When comparing the retinoblastoma-containing eyes with the contralateral normal eyes, the peak systolic and end-diastolic velocities of the central retinal artery were significantly higher in the tumorous eyes than in the normal eyes before intra-arterial chemotherapy. Moreover, the peak systolic and end-diastolic velocities in the posterior ciliary and central retinal arteries were significantly decreased after intra-arterial chemotherapy in the tumorous eyes (p<0.05). There were no statistically significant differences in the other parameters.
  
  
  
  Our results suggest that intra-arterial chemotherapy has a measurable effect on the retrobulbar blood flow, which can cause a decrease in the peak systolic and end-diastolic velocities in the posterior ciliary and central retinal arteries.
authors.affiliation: Department of Ophthalmology and Shanghai Key Laboratory of Visual Impairment and Restoration, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Xue
authors.affiliation: Department of Ophthalmology and Shanghai Key Laboratory of Visual Impairment and Restoration, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
authors.forename: Ailin
authors.initials: A
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology and Shanghai Key Laboratory of Visual Impairment and Restoration, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
authors.forename: Ren
authors.initials: R
authors.lastname: Hui
authors.affiliation: Guangzhou Women and Children's Medical Center, Guangzhou, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology and Shanghai Key Laboratory of Visual Impairment and Restoration, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Qian
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001783:Blood Flow Velocity; D016190:Carboplatin / Q000008:administration & dosage; D002675:Child, Preschool; D019842:Ciliary Arteries / Q000187:drug effects / Q000502:physiology; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D007223:Infant; D007261:Infusions, Intra-Arterial; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D009880:Ophthalmic Artery / Q000502:physiology; D009915:Orbit / Q000098:blood supply*; D011673:Pulsatile Flow / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects* / Q000502:physiology; D012161:Retinal Artery / Q000187:drug effects / Q000502:physiology; D019572:Retinal Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D012175:Retinoblastoma / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D016190:Carboplatin; D008558:Melphalan
keywords: Child health (paediatrics); Neoplasia; Retina