title: Formal Asymmetric α-Alkenylation of Aldehydes and the Synthetic Application toward Forming α-exo-Methylene-γ-butyrolactones and Skipped Dienes.
abstract: A formal asymmetric α-alkenylation of aldehydes is reported based on the organocatalytic reaction of aldehydes with nitroacrylates. The reaction proceeds in a one-pot manner forming the products with up to 77% yield and up to >99% ee. This strategy is also successfully applied for the synthesis of α-exo-methylene-γ-butyrolactones and skipped diene scaffolds in a highly enantioselective manner.
authors.affiliation: Department of Chemistry, Aarhus University , Langelandsgade 140, DK-8000 Aarhus C, Denmark.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Chemistry, Aarhus University , Langelandsgade 140, DK-8000 Aarhus C, Denmark.
authors.forename: Lise
authors.initials: L
authors.lastname: Ibsen
authors.affiliation: Department of Chemistry, Aarhus University , Langelandsgade 140, DK-8000 Aarhus C, Denmark.
authors.forename: Karl Anker
authors.identifier: 0000-0002-3482-6236
authors.initials: KA
authors.lastname: Jørgensen