title: Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils of Selected Aromatic Plants from Tajikistan.
abstract: Antimicrobial, antioxidant, and anti-inflammatory activities of the essential oils of 18 plant species from Tajikistan (Central Asia) were investigated. The essential oil ofOriganum tyttanthumshowed a strong antibacterial activity with both minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 312.5 µg/mL forE. coli, 625 µg/mL (MIC) and 1250 µg/mL (MBC) for MRSA (methicillin-resistant Staphylococcus aureus), respectively. The essential oil ofGalagania fragrantissimawas highly active against MRSA at concentrations as low as 39.1 µg/mL and 78.2 µg/mL for MIC and MBC, respectively.Origanum tyttanthumessential oil showed the highest antioxidant activity with IC50values of 0.12 mg/mL for ABTS (2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid)) and 0.28 mg/mL for DPPH (2,2-diphenyl-1-picrylhydrazyl).Galagania fragrantissimaandOriganum tyttanthumessential oils showed the highest anti-inflammatory activity; IC50values of 5-lipoxygenase (5-LOX) inhibition were 7.34 and 14.78 µg/mL, respectively. In conclusion, essential oils ofOriganumtyttanthumandGalagania fragrantissimaexhibit substantial antimicrobial, antioxidant, and anti-inflammatory activities. They are interesting candidates in phytotherapy.
authors.affiliation: Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, Heidelberg 69120, Germany. sharopov@uni-heidelberg.de.
authors.forename: Farukh
authors.initials: F
authors.lastname: Sharopov
authors.affiliation: Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, Heidelberg 69120, Germany. m.braun@uni-heidelberg.de.
authors.forename: Markus Santhosh
authors.initials: MS
authors.lastname: Braun
authors.affiliation: Tajik State Medical University, Rudaki Str. 139, Dushanbe 734025, Tajikistan. gulmurodov@mail.ru.
authors.forename: Isomiddin
authors.initials: I
authors.lastname: Gulmurodov
authors.affiliation: Tajik State Medical University, Rudaki Str. 139, Dushanbe 734025, Tajikistan. nifc@list.ru.
authors.forename: Davlat
authors.initials: D
authors.lastname: Khalifaev
authors.affiliation: Tajik State Medical University, Rudaki Str. 139, Dushanbe 734025, Tajikistan. salomidin@mail.ru.
authors.forename: Salomiddin
authors.initials: S
authors.lastname: Isupov
authors.affiliation: Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, Heidelberg 69120, Germany. wink@uni-heidelberg.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Wink
keywords: anti-inflammation; antimicrobial activity; antioxidant activity; aromatic plant; essential oil