title: Factors influencing the need for endoscopic sinus surgery in adult patients with cystic fibrosis.
abstract: BACKGROUND
  Risk factors in adult patients with cystic fibrosis (CF) associated with surgical intervention have not been delineated.
  
  
  OBJECTIVE
  To identify characteristics of adult patients with CF and with chronic rhinosinusitis that predict surgical intervention with endoscopic sinus surgery (ESS).
  
  
  METHODS
  Patients were identified in a tertiary sinus center by the International Classification of Diseases, Ninth Revision codes 277.00-277.03, which represent CF. Charts were reviewed for the CF transmembrane conductance regulator (CFTR) gene mutation, Lund-Mackay score (LMS), the 22-item Sino-Nasal Outcome Test (SNOT-22) score, previous ESS, and occurrence of ESS after presentation. The Fisher exact test was used to test frequency of events between the groups, and the Mann Whitney U test and the t-test were used to compare means among LMS, SNOT-22, and age. The Cox proportional hazard analysis was used to calculate hazard ratios (HR) for the impact of LMS, SNOT-22 score, previous ESS, and CFTR gene mutation status on the occurrence of ESS after presentation.
  
  
  RESULTS
  One hundred and fifteen patients met the inclusion criteria for the study. Patients with a history of surgery more often underwent ESS after presentation (p ≤ 0.01). The LMS and the SNOT-22 score were not significantly different between the groups of previous ESS and no previous ESS (p = 0.23 and p = 0.28, respectively). A severe mutation genotype was predictive of ESS after presentation (p = 0.03). SNOT-22 scores did not differ between the severe and mild groups (36.0 and 32.4, respectively; p = 0.57), but the mean LMS was significantly higher in the severe mutation group (12.5 and 9.7; p ≤ 0.01). Univariate Cox proportional hazard analysis revealed an increased occurrence of ESS for patients with severe mutations (HR, 3.6; p ≤ 0.01) or a history of ESS (HR, 2.3; p ≤ 0.01).
  
  
  CONCLUSIONS
  The occurrence of ESS in adult patients with CF was predicted by previous ESS intervention as well as the severity of CFTR mutation.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Brook
authors.forename: Alice Z
authors.initials: AZ
authors.lastname: Maxfield
authors.forename: Hena
authors.initials: H
authors.lastname: Ahmed
authors.forename: Ahmad R
authors.initials: AR
authors.lastname: Sedaghat
authors.forename: Eric H
authors.initials: EH
authors.lastname: Holbrook
authors.forename: Stacey T
authors.initials: ST
authors.lastname: Gray
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000453:epidemiology* / Q000601:surgery; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics*; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D009298:Nasal Polyps / Q000453:epidemiology* / Q000601:surgery; D059747:Nasal Surgical Procedures; D010256:Paranasal Sinuses / Q000601:surgery; D012220:Rhinitis / Q000453:epidemiology* / Q000601:surgery; D012306:Risk; D012852:Sinusitis / Q000453:epidemiology* / Q000601:surgery
chemical_list: D019005:Cystic Fibrosis Transmembrane Conductance Regulator