title: Polarized Exocytosis.
abstract: Polarized exocytosis is generally considered as the multistep vesicular trafficking process in which membrane-bounded carriers are transported from the Golgi or endosomal compartments to specific sites of the plasma membrane. Polarized exocytosis in cells is achieved through the coordinated actions of membrane trafficking machinery and cytoskeleton orchestrated by signaling molecules such as the Rho family of small GTPases. Elucidating the molecular mechanisms of polarized exocytosis is essential to our understanding of a wide range of pathophysiological processes from neuronal development to tumor invasion.
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Key Laboratory for Regenerative Medicine of Ministry of Education and Department of Developmental & Regenerative Biology, Jinan University, Guangzhou 510632, P.R. China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Feng
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement; D002923:Cilia / Q000378:metabolism; D048749:Cytokinesis; D003599:Cytoskeleton / Q000378:metabolism*; D004847:Epithelial Cells; D005089:Exocytosis / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009474:Neurons / Q000378:metabolism; D010716:Phosphatidylinositols / Q000737:chemistry; D050600:SNARE Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D015398:Signal Transduction; D020725:ral GTP-Binding Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D000199:Actins; D010716:Phosphatidylinositols; D050600:SNARE Proteins; D020558:GTP Phosphohydrolases; D020725:ral GTP-Binding Proteins; D020741:rho GTP-Binding Proteins