title: [Research Progress on Notch Signal Pathway in Acute Graft-Versus-Host Disease -Review].
abstract: The Notch signaling pathway is a highly conserved cell signaling system that plays an essential role in many biological processes. Notch signaling regulates multiple aspects of hematopoiesis, especially during T cell develop-ment. Recent data suggest that Notch also regulates mature T cell differentiation and function. The latest data show that Notch also plays an essential role in alloreactive T cells mediating acute graft-versus-host disease (aGVHD), the most severe complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Notch inhibition in donor-derived T cells or blockade of individual Notch ligands and receptors after transplantation can reduce GVHD severity and mortality in mouse models of allo-HSCT, without causing global immunosuppression. These findings indicate Notch in T cells as an attractive therapeutic target to control aGVHD. In this article, the pathophysiology of aGVHD, the Notch signal pathway and aGVHD are reviewed.
authors.affiliation: Department of Hematology, The Central Hospital of Taian, Taian 271000, Shandong Province, China .E-mail: dongmeiguo@aliyun.com.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Guo
authors.affiliation: Department of Hematology, The Central Hospital of Taian, Taian 271000, Shandong Province, China.
authors.forename: Ban-Ban
authors.initials: BB
authors.lastname: Li
authors.affiliation: Department of Hematology, The Central Hospital of Taian, Taian 271000, Shandong Province, China.
authors.forename: Chun-Pu
authors.initials: CP
authors.lastname: Li
authors.affiliation: Department of Hematology, The Central Hospital of Taian, Taian 271000, Shandong Province, China.
authors.forename: Qing-Liang
authors.initials: QL
authors.lastname: Teng
mesh_terms: D000208:Acute Disease; D000818:Animals; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D051379:Mice; D015398:Signal Transduction; D013601:T-Lymphocytes; D014184:Transplantation, Homologous