title: [Two Cases of Fournier's Gangrene That Occurred during Chemotherapy for Rectal Cancer].
abstract: Two cases of Fournier's gangrene occurred during chemotherapy for advanced rectal cancer. Patients were treated using surgical debridement and antibiotic therapy. Case 1: A 66-year-old man had advanced rectal cancer with para-aortic and inguinal lymph node metastases. He received a sigmoid colostomy and chemotherapy(capecitabine, oxaliplatin, bevacizumab). Due to progression of the rectal mass, we performed radiotherapy(30 Gy)and chemotherapy(irinotecan, S-1, bevacizumab). After 14 days, he was hospitalized with a diagnosis of Fournier's gangrene with anal pain and fever. Case 2: A 63-year-old man had mucinous rectal carcinoma with sacrum invasion. He received a sigmoid colostomy and chemotherapy. Sixteen days after regorafenib therapy, as a fifth-line of chemotherapy, he was hospitalized with a diagnosis of Fournier's gangrene with hip pain, swollen perineum, and fever. There have been no reports of Fournier's gangrene occurring during chemotherapy for rectal cancer. We report 2 cases with a review of literature.
authors.affiliation: Dept. of Digestive Surgery, Shinshu University School of Medicine.
authors.forename: Makoto
authors.initials: M
authors.lastname: Koyama
authors.forename: Masato
authors.initials: M
authors.lastname: Kitazawa
authors.forename: Takehito
authors.initials: T
authors.lastname: Ehara
authors.forename: Yuta
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Akira
authors.initials: A
authors.lastname: Suzuki
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Miyagawa
authors.forename: Shinichi
authors.initials: S
authors.lastname: Miyagawa
mesh_terms: D000368:Aged; D059248:Chemoradiotherapy; D018934:Fournier Gangrene / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000150:complications / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome