title: INTRAVITREAL DEXAMETHASONE IMPLANT IN RETINITIS PIGMENTOSA-RELATED CYSTOID MACULAR EDEMA.
abstract: OBJECTIVE
  To report the clinical outcome after intravitreal dexamethasone implant in patients with retinitis pigmentosa and cystoid macular edema.
  
  
  METHODS
  Multicenter retrospective case series of eyes with retinitis pigmentosa and cystoid macular edema that underwent intravitreal dexamethasone implant. Primary outcome measures were best-corrected visual acuity in LogMAR and central macular thickness. Statistical analyses used two-tailed comparison with Wilcoxon signed-rank test.
  
  
  RESULTS
  There were a total of 45 eyes from 34 patients with a mean age of 32.7 years (range 16-57) and mean follow-up of 15.5 ± 13.0 months. At Month 3 after the first injection, mean initial best-corrected visual acuity improved from 0.61 ± 0.38 (20/81) to 0.37 ± 0.16 (20/47) (P = 0.012), whereas mean central macular thickness (μm) decreased from 506 ± 288 μm to 311.7 ± 71.6 μm (P < 0.001) and mean intraocular pressure increased from 15.7 ± 2.3 mmHg to 19.8 ± 11.0 mmHg (P = 0.01). Fourteen eyes had multiple injections (1-7 reinjections) at a mean interval of 6 months. Treatment effect was durable with multiple injections, but with seven eyes developing visually significant cataracts.
  
  
  CONCLUSIONS
  Best-corrected visual acuity improved up to 4 months in around half of the eyes. Eyes that benefited the most were pseudophakic, steroid nonresponsive, with large initial central macular thickness, and profuse fluorescein dye leakage.
authors.affiliation: Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon.|Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.
authors.forename: Ahmad M
authors.initials: AM
authors.lastname: Mansour
authors.affiliation: Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.
authors.forename: Huda
authors.initials: H
authors.lastname: Sheheitli
authors.affiliation: Department of Ophthalmology, Izmir University Faculty of Medicine, Izmir, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Kucukerdonmez
authors.affiliation: Department of Ophthalmology, Cincinnati Eye Institute, University of Cincinnati, Cincinnati, Ohio.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Sisk
authors.affiliation: Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Raphael
authors.initials: R
authors.lastname: Moura
authors.affiliation: Department of Ophthalmology, University of Athens, Athens, Greece.
authors.forename: Marilita M
authors.initials: MM
authors.lastname: Moschos
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Luiz H
authors.initials: LH
authors.lastname: Lima
authors.affiliation: Vascular Medicine Program, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Laila
authors.initials: L
authors.lastname: Al-Shaar
authors.affiliation: Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
authors.forename: J Fernando
authors.initials: JF
authors.lastname: Arevalo
authors.affiliation: Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Maia
authors.affiliation: Department of Ophthalmology, Cincinnati Eye Institute, University of Cincinnati, Cincinnati, Ohio.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Foster
authors.affiliation: Department of Ophthalmology, Celal Bayar University, Manisa, Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Kayikcioglu
authors.affiliation: Division of Vitreoretinal Diseases and Surgery, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Igor
authors.initials: I
authors.lastname: Kozak
authors.affiliation: Department of Ophthalmology, Wake Forest University, Winston Salem, North Carolina.
authors.forename: Shree
authors.initials: S
authors.lastname: Kurup
authors.affiliation: Retina Associates of Cleveland, Beachwood, Ohio.
authors.forename: Hernando
authors.initials: H
authors.lastname: Zegarra
authors.affiliation: Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, Spain.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gallego-Pinazo
authors.affiliation: Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.
authors.forename: Rola N
authors.initials: RN
authors.lastname: Hamam
authors.affiliation: Department of Ophthalmology, Hotel Dieu de France, Beirut, Lebanon.
authors.forename: Riad A
authors.initials: RA
authors.lastname: Bejjani
authors.affiliation: Department of Ophthalmology, Izmir University Faculty of Medicine, Izmir, Turkey.
authors.forename: Esat
authors.initials: E
authors.lastname: Cinar
authors.affiliation: Department of Ophthalmology, Ekol Eye Hospital, Izmir, Turkey.
authors.forename: Ethem T
authors.initials: ET
authors.lastname: Erakgün
authors.affiliation: Department of Ophthalmology, University of Colorado, Aurora, Colorado.
authors.forename: Alan
authors.initials: A
authors.lastname: Kimura
authors.affiliation: School of Medicine, Catholic University Brasilia, Brasilia, Brazil.
authors.forename: Anderson
authors.initials: A
authors.lastname: Teixeira
mesh_terms: D000293:Adolescent; D000328:Adult; D003907:Dexamethasone / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004343:Drug Implants; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D058449:Intravitreal Injections; D008266:Macula Lutea / Q000187:drug effects / Q000473:pathology*; D008269:Macular Edema / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012174:Retinitis Pigmentosa / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone