title: Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study.
abstract: Yolk sac tumor of the ovary is a rare but highly malignant and aggressive germ cell tumor. The objective of this case study of an ovarian yolk sac tumor was to identify putative pathways that are known to pose a block in differentiation, both in early embryogenesis and in tumorigenesis, that might be amenable to low toxicity therapies designed to promote differentiation to a more benign state and prevent recurrent disease in such tumors. The enhancer of Zeste homolog 2 (EZH2), a histone methyl transferase, and silent mating type information regulation 2 homolog 1 (SIRT1), a NAD+ histone deacetylase, are two such pathways.
authors.affiliation: Department of Pathology and Laboratory Medicine, UT Health-McGovern Medical School, Houston, TX, USA Yumi.a.kojima@uth.tmc.edu.
authors.forename: Yumi A
authors.initials: YA
authors.lastname: Kojima
authors.affiliation: Department of Pathology and Laboratory Medicine, UT Health-McGovern Medical School, Houston, TX, USA.
authors.forename: Binara
authors.initials: B
authors.lastname: Assylbekova
authors.affiliation: Department of Pathology and Laboratory Medicine, UT Health-McGovern Medical School, Houston, TX, USA.
authors.forename: Bihong
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Department of Obstetrics and Gynecology UT Health-McGovern Medical School, Houston, TX, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Nugent
authors.affiliation: Department of Pathology and Laboratory Medicine, UT Health-McGovern Medical School, Houston, TX, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Brown
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation; D018240:Endodermal Sinus Tumor / Q000378:metabolism* / Q000473:pathology*; D000071221:Enhancer of Zeste Homolog 2 Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D040901:Proteomics / Q000379:methods*; D015398:Signal Transduction; D056564:Sirtuin 1 / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D000071221:Enhancer of Zeste Homolog 2 Protein; D056564:Sirtuin 1
keywords: EZH2; Morphoproteomics; SIRT1; yolk sac tumor