title: Dependence between LD50for Rodents and LC50for Adult Fish and Fish Embryos.
abstract: We revealed empirical dependences between common logarithm of a ratio of rat oral LD50to LCa50for adult fish and lgP for 50 different chemicals; and common logarithm of a ratio of the oral LD50in rodents to LCe50for fish embryos and lgP for 30 different chemicals. The dependences were obtained by constructing a trend line between experimental points and calculation of Pearson's R correlation coefficient as a measure of regression significance. These dependences can show the influence of substance lipophilicity on its toxicity for aquatic organisms comparing to mammals.
authors.affiliation: V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia. fireaxe@mail.ru.
authors.forename: K V
authors.initials: KV
authors.lastname: Zolotarev
authors.affiliation: V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: N F
authors.initials: NF
authors.lastname: Belyaeva
authors.affiliation: V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Mikhailov
authors.affiliation: V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Mikhailova
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D006839:Hydrocarbons, Acyclic / Q000633:toxicity*; D006841:Hydrocarbons, Aromatic / Q000633:toxicity*; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D020128:Inhibitory Concentration 50; D007928:Lethal Dose 50; D016014:Linear Models; D051379:Mice; D055553:Prescription Drugs / Q000633:toxicity*; D051381:Rats; D013045:Species Specificity; D023382:Toxicity Tests, Acute / Q000592:standards* / Q000706:statistics & numerical data; D015027:Zebrafish
chemical_list: D006839:Hydrocarbons, Acyclic; D006841:Hydrocarbons, Aromatic; D006846:Hydrocarbons, Halogenated; D055553:Prescription Drugs
keywords: LC a 50 for adult fish; LCe 50 for fish embryos; LD50 for rodents; distribution coefficient lgP; empiric dependences