title: Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016.
abstract: Twenty-seven colistin-resistant, carbapenemase-producingKlebsiella pneumoniaeisolates were identified from hospitals in Serbia. All isolates wereblaCTX-M-15positive; ST101, ST888, ST437, ST336, and ST307 wereblaOXA-48positive; and ST340 wasblaNDM-1positive. ST307 had an insertion, and ST336 had a premature stop codon in themgrBgene. Amino acid substitutions were detected in PmrAB of isolates ST101, ST888, ST336, and ST307. Themcr-1andmcr-2were not detected. An increase inphoP,phoQ, andpmrKgene transcription was detected for all sequence types.
authors.affiliation: Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.
authors.forename: Katarina
authors.initials: K
authors.lastname: Novović
authors.affiliation: Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.|Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia.
authors.forename: Anika
authors.initials: A
authors.lastname: Trudić
authors.affiliation: Institute for Laboratory Diagnostics Konzilijum, Belgrade, Serbia.
authors.forename: Snežana
authors.initials: S
authors.lastname: Brkić
authors.affiliation: Department of Clinical Microbiology, Mother and Child Health Care Institute of Serbia Dr. Vukan Cupic, Belgrade, Serbia.
authors.forename: Zorica
authors.initials: Z
authors.lastname: Vasiljević
authors.affiliation: Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.
authors.forename: Milan
authors.initials: M
authors.lastname: Kojić
authors.affiliation: Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.|Institute of Public Health of Vojvodina, Novi Sad, Serbia.
authors.forename: Deana
authors.initials: D
authors.lastname: Medić
authors.affiliation: Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Ćirković
authors.affiliation: Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia bjovcic@bio.bg.ac.rs.|Faculty of Biology, University of Belgrade, Belgrade, Serbia.
authors.forename: Branko
authors.identifier: 0000-0002-9500-3786
authors.initials: B
authors.lastname: Jovčić
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis*; D002675:Child, Preschool; D003091:Colistin / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D055771:Serbia / Q000453:epidemiology; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D001426:Bacterial Proteins; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; C063912:carbapenemase; C108449:oxacillinase; D003091:Colistin
keywords: Klebsiella pneumoniae; carbapenem resistance; colistin resistance; molecular epidemiology