title: Extended pulsated drug release from PLGA-based minirods.
abstract: The kinetics of degradation and sustained cancer drugs (paclitaxel (PT) and prodigiosin (PG)) release are presented for minirods (each with diameter of ~5 and ~6 mm thick). Drug release and degradation mechanisms were studied from solvent-casted cancer drug-based minirods under in vitro conditions in phosphate buffer solution (PBS) at a pH of 7.4. The immersed minirods were mechanically agitated at 60 revolutions per minute (rpm) under incubation at 37 °C throughout the period of the study. The kinetics of drug release was studied using ultraviolet visible spectrometry (UV-Vis). This was used to determine the amount of drug released at 535 nm for poly(lactic-co-glycolic acid) loaded with prodigiosin (PLGA-PG) samples, and at 210 nm, for paclitaxel-loaded samples (PLGA-PT). The degradation characteristics of PLGA-PG and PLGA-PT are elucidated using optical microscope as well as scanning electron microscope (SEM). Statistical analysis of drug release and degradation mechanisms of PLGA-based minirods were performed. The implications of the results are discussed for potential applications in implantable/degradable structures for multi-pulse cancer drug delivery.
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria.|Department of Materials Science and Engineering, Kwara State University, Ilorin, Nigeria.
authors.forename: Y
authors.initials: Y
authors.lastname: Danyuo
authors.affiliation: Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), Abuja, Federal Capital Territory, Nigeria.
authors.forename: O
authors.initials: O
authors.lastname: E Oberaifo
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria.|Department of Mechanical and Aerospace Engineering 41 Olden Street, Princeton University, Princeton, NJ, 08544, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Obayemi
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria.|Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), Abuja, Federal Capital Territory, Nigeria.
authors.forename: S
authors.initials: S
authors.lastname: Dozie-Nwachukwu
authors.affiliation: Department of Theoretical Physics, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria.|Department of Physics, Salem University, Lokoja-Ajaokuta Road, Lokoja, Kogi, Nigeria.
authors.forename: C
authors.initials: C
authors.lastname: J Ani
authors.affiliation: Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), Abuja, Federal Capital Territory, Nigeria.
authors.forename: O S
authors.initials: OS
authors.lastname: Odusanya
authors.affiliation: Department of Materials Science and Engineering, Kwara State University, Ilorin, Nigeria.
authors.forename: M G
authors.initials: MG
authors.lastname: Zebaze Kana
authors.affiliation: Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, 70 Prospect Street, Princeton, NJ, 08544, USA.
authors.forename: K
authors.initials: K
authors.lastname: Malatesta
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria. soboyejo@princeton.edu.|Department of Mechanical and Aerospace Engineering 41 Olden Street, Princeton University, Princeton, NJ, 08544, USA. soboyejo@princeton.edu.|Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, 70 Prospect Street, Princeton, NJ, 08544, USA. soboyejo@princeton.edu.
authors.forename: W O
authors.initials: WO
authors.lastname: Soboyejo
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers; D065546:Drug Liberation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D009369:Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D011353:Prodigiosin / Q000008:administration & dosage; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011353:Prodigiosin; D017239:Paclitaxel