title: A Novel Approach to Identifying a Neuroimaging Biomarker for Patients With Serious Mental Illness.
abstract: Serious mental illness (SMI) is disabling, and current interventions are ineffective for many. This exploratory study sought to demonstrate the feasibility of applying topological data analysis (TDA) to resting-state functional connectivity data obtained from a heterogeneous sample of 235 adult inpatients to identify a biomarker of treatment response. TDA identified two groups based on connectivity between the prefrontal cortex and striatal regions: patients admitted with greater functional connectivity between these regions evidenced less improvement from admission to discharge than patients with lesser connectivity between them. TDA identified a potential biomarker of an attenuated treatment response among inpatients with SMI. Insofar as the observed pattern of resting-state functional connectivity collected early during treatment is replicable, this potential biomarker may indicate the need to modify standard of care for a small, albeit meaningful, percentage of patients.
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: Alok
authors.initials: A
authors.lastname: Madan
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: J Christopher
authors.initials: JC
authors.lastname: Fowler
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Patriquin
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: Ramiro
authors.initials: R
authors.lastname: Salas
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: Philip R
authors.initials: PR
authors.lastname: Baldwin
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: Kenia M
authors.initials: KM
authors.lastname: Velasquez
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: Humsini
authors.initials: H
authors.lastname: Viswanath
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: David L
authors.initials: DL
authors.lastname: Molfese
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: Carla
authors.initials: C
authors.lastname: Sharp
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: Jon G
authors.initials: JG
authors.lastname: Allen
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: Susan
authors.initials: S
authors.lastname: Hardesty
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: John M
authors.initials: JM
authors.lastname: Oldham
authors.affiliation: From the Menninger Clinic, Houston, Tex. (AM, CF, MAP, CS, JGA, SH, JMO, BCF); the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (AM, JCF, MAP, RS, PRB, KMV, HV, DLM, JGA, SH, JMO); the Department of Psychology, University of Houston, Houston, Tex. (CS); and the Department of Psychology, University of Hawaii, Hilo, Hawaii (BCF).
authors.forename: B Christopher
authors.initials: BC
authors.lastname: Frueh
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D001523:Mental Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D012146:Rest; D057566:Self Report; D016896:Treatment Outcome
keywords: Diagnosis and Classification in Neuropsychiatry; Imaging Techniques; Outcome Studies Biological/Pharmacological; Research Design and Methodology