title: Atorvastatin-induced dermatomyositis.
abstract: A 49-year-old man with no previous history of musculoskeletal or cutaneous problems who had a myocardial infarction (MI) was treated with atorvastatin, prasugrel, enoxaparine, and diltiazem following percutaneous coronary intervention. He was referred to our rheumatology outpatient clinic for rash and papules on the knuckles, face, and neck, as well as proximal muscle weakness. In the physical examination, a reddish rash on the face and Gottron's papules on the knuckles were detected. The skin biopsy performed indicated interface dermatitis with hydropic degeneration of basal keratinocytes, supporting the clinical impression of dermatomyositis. He was started on prednisolone 1 mg/kg/day. After 30 days of prednisolone therapy, all symptoms disappeared.
authors.affiliation: Division of Internal Medicine, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey. dr.mertoztas@gmail.com.
authors.forename: Mert
authors.initials: M
authors.lastname: Oztas
authors.affiliation: Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey.
authors.forename: Serdal
authors.initials: S
authors.lastname: Ugurlu
authors.affiliation: Department of Pathology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey.
authors.forename: Ovgu
authors.initials: O
authors.lastname: Aydin
mesh_terms: D000069059:Atorvastatin / Q000009:adverse effects*; D001706:Biopsy; D003882:Dermatomyositis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011239:Prednisolone; D000069059:Atorvastatin
keywords: Atorvastatin; Dermatomyositis; Statin-induced dermatomyositis