title: Prostate cancer before renal transplantation: A multicentre study.
abstract: BACKGROUND
  The surgical issues of renal transplantation (RT) after localized prostate cancer (PC) treatment and oncological outcomes after transplantation in patients on the waiting list with a history of PC were unknown. We conducted a retrospective multicentre study including all patients with PC diagnosed before the kidney transplantation.
  
  
  METHODS
  Fifty-two patients were included from December 1993 to December 2015. The median age at diagnosis of PC was 59.8years old.
  
  
  RESULTS
  The median PSA rate at diagnosis was 7ng/mL. Twenty-seven, Twenty-four, and one PC were respectively low, intermediate and high risk according to d'Amico classification. Forty-three patients were treated by radical prostatectomy (RP): 28 retropubic, 15 laparoscopic and 3 by a perineal approach. Eighteen patients had a lymph node dissection. Four patients were treated with external radiotherapy and 2 by brachytherapy. Eight patients underwent radiotherapy after surgery. The median time between PC treatment and RT was 35.7 months. The median operating time for the renal transplantation was 180min (IQR 150-190; min 90-max 310) with a median intraoperative bleeding of 200mL (IQR 100-290; min 50-max 2000). A history of lymphadenectomy did not significantly lengthen operative time (P=0.34). No recurrence of PC was observed after a median follow of 36months.
  
  
  CONCLUSIONS
  PC discovered before RT should be treated with RP to assess the risk of recurrence and decrease waiting for a RT. If the PC is at low risk of recurrence, it seems possible to shorten the waiting time before the RT after a multidisciplinary discussion meeting.
  
  
  METHODS
  4.
authors.affiliation: Urology and Transplantation department, CHU Côte-de-Nacre, Caen, France; Normandie Univ, France; UNICAEN, Caen, France.
authors.forename: C
authors.initials: C
authors.lastname: Chahwan
authors.affiliation: Urology and Transplantation department, CHU Côte-de-Nacre, Caen, France.
authors.forename: A
authors.initials: A
authors.lastname: Doerfler
authors.affiliation: Urology and Transplantation department, CHU de Tours, Tours, France.
authors.forename: N
authors.initials: N
authors.lastname: Brichart
authors.affiliation: Urology and Transplantation department, CHRU de Lille, Lille, France.
authors.forename: S
authors.initials: S
authors.lastname: Bouyé
authors.affiliation: Urology and Transplantation department, CHU d'Angers, Angers, France.
authors.forename: T
authors.initials: T
authors.lastname: Culty
authors.affiliation: Urology and Transplantation department, hôpitaux universitaire de Genève, Genève, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Iselin
authors.affiliation: Urology and Transplantation department, CHU de Rouen, Rouen, France.
authors.forename: C
authors.initials: C
authors.lastname: Pfister
authors.affiliation: Urology and Transplantation department, CHU de Toulouse, Toulouse, France.
authors.forename: F
authors.initials: F
authors.lastname: Sallusto
authors.affiliation: Urology and Transplantation department, CHU Henri-Mondor, Créteil-Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Salomon
authors.affiliation: Urology and Transplantation department, CHU de Rennes, Rennes, France.
authors.forename: G
authors.initials: G
authors.lastname: Verhoest
authors.affiliation: Urology and Transplantation department, CHU d'Amiens, Amiens, France.
authors.forename: L
authors.initials: L
authors.lastname: Viart
authors.affiliation: Urology and Transplantation department, CHU Côte-de-Nacre, Caen, France; Normandie Univ, France; UNICAEN, Caen, France. Electronic address: xavtillou@gmail.com.
authors.forename: X
authors.initials: X
authors.lastname: Tillou
mesh_terms: D016063:Blood Loss, Surgical; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000628:therapy*; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies
chemical_list: D017430:Prostate-Specific Antigen
keywords: Cancer de prostate; Kidney transplantation; Prostatic neoplasms; Transplantation rénale