title: Phenolic compounds isolated from Dioscorea zingiberensis protect against pancreatic acinar cells necrosis induced by sodium taurocholate.
abstract: One new bibenzyl (1) and one new phenanthrene (2), together with two known bibenzyls (3-4) and four known diarylheptanoids (5-8) were isolated from the rhizomes of Dioscorea zingiberensis. The structures of 1-2 were elucidated by spectroscopic methods including 1D and 2D NMR. Phenols 1-8 were evaluated for their anti-pancreatitic activities on sodium taurocholate (NaT)-induced pancreatic acinars necrosis. Notably, 0.5mM of compound 6 exhibited comparable inhibitory effect with 5mM of caffeine. Furthermore, compound 6 prevented the ATP depletion and excessive ROS production which could be also involved in mitochondria-mediated injuries in acute pancreatitis. As a result, compound 6 has been demonstrated to be a potential candidate for mediating mitochondrial dysfunction to prevent pancreatic necrosis. This study is also the first report on the isolation of bibenzyls and diarylheptanoids from this plant.
authors.affiliation: West China-Washington Mitochondria and Metabolism Center, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China. Electronic address: dudan1520@163.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Du
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jin
authors.affiliation: Laboratory of Ethnopharmacology, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: West China-Washington Mitochondria and Metabolism Center, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Hu
authors.affiliation: Laboratory of Ethnopharmacology, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Xing
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: Na
authors.initials: N
authors.lastname: Shi
authors.affiliation: Laboratory of Ethnopharmacology, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.affiliation: West China-Washington Mitochondria and Metabolism Center, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China. Electronic address: gongmeng@scu.edu.cn.
authors.forename: Meng
authors.initials: M
authors.lastname: Gong
mesh_terms: D061354:Acinar Cells / Q000187:drug effects*; D027742:Dioscorea / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010179:Pancreas / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D010636:Phenols; D017382:Reactive Oxygen Species
keywords: Acinar cell; Bibenzyl; Diarylheptanoid; Necrosis; Pancreatitis; Phenol