title: Capillary Index Score and Correlation with Outcomes in Acute Ischemic Stroke: A Meta-analysis.
abstract: OBJECTIVE
  The capillary index score (CIS) has been recently introduced as a metric for rating the collateral circulation of ischemic stroke patients. Multiple studies in the last five years have evaluated the correlation of good CIS with clinical outcomes and suggested the use of CIS in selecting patients for endovascular treatment. We performed a meta-analysis of these studies comparing CIS with clinical outcomes.
  
  
  METHODS
  We conducted a computerized search of three databases from January 2011 to November 2015 for studies related to CIS and outcomes. A CIS = 0 or 1 is considered poor (pCIS) and a CIS = 2 or 3 is considered favorable (fCIS). Using random-effect meta-analysis, we evaluated the relationship of CIS to neurological outcome (modified Rankin scale score ≤ 2), recanalization, and post-treatment hemorrhage. Meta-regression analysis of good neurological outcome was performed for adjusting baseline National Institutes of Health Stroke Scale (NIHSS) between groups.
  
  
  RESULTS
  Six studies totaling 338 patients (212 with fCISs and 126 with pCISs) were included in the analysis. Patients with fCIS had higher likelihood of good neurological outcome [relative risk (RR) = 3.03; confidence interval (CI) = 95%, 2.05-4.47;p< 0.001] and lower risk of post-treatment hemorrhage (RR = 0.38; CI = 95%, 0.19-0.93;p= 0.04) as compared with patients in the pCIS group. When adjusting for baseline NIHSS, patients with fCIS had higher RR of good neurological outcome when compared with those with pCIS (RR = 2.94; CI = 95%, 1.23-7,p< 0.0001). Favorable CIS was not associated with higher rates of recanalization.
  
  
  CONCLUSIONS
  Observational evidence suggests that acute ischemic stroke patients with fCIS may have higher rates of good neurological outcomes compared with patients with pCIS, independent of baseline NIHSS. CIS may be used as another tool to select patients for endovascular treatment of acute ischemic stroke.
authors.forename: Manoj
authors.initials: M
authors.lastname: Jagani
authors.forename: Waleed
authors.initials: W
authors.lastname: Brinjikji
authors.forename: Mohammad H
authors.initials: MH
authors.lastname: Murad
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Rabinstein
authors.forename: Harry J
authors.initials: HJ
authors.lastname: Cloft
authors.forename: David F
authors.initials: DF
authors.lastname: Kallmes