title: CXCR4: A New Player in an Old Scene?
abstract: Transmembrane C-X-C chemokine receptor 4 (CXCR4) and its ligand C-X-C motif chemokine 12 (CXCL12) came into focus in many solid cancers, allowing a more fundamental diagnostic and therapeutic approach by modulating the immune response against cancer cells. CXCR4 and CXCL12 mediate cell proliferation, migration, and metastatic outgrowth in head and neck squamous cell carcinoma (HNSCC) and are strongly associated with cancer recurrence and patient survival. Despite recent advances in molecular imaging and cancer therapy in lymphoma using CXCL12 analogues, clinical trials evaluating the diagnostic and therapeutic impact on HNSCC are missing.
authors.affiliation: Hals-Nasen-Ohrenklinik und Poliklinik, Technische Universität München, Munich, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Knopf
authors.forename: Marie Kristin
authors.initials: MK
authors.lastname: Fritsche
authors.forename: Yin
authors.initials: Y
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D016923:Cell Death / Q000235:genetics; D054377:Chemokine CXCL12 / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D012313:RNA / Q000235:genetics; D019718:Receptors, CXCR4 / Q000235:genetics*; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D015398:Signal Transduction / Q000235:genetics; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019718:Receptors, CXCR4; D012313:RNA