title: Differential Clinicopathological Features in Spontaneous Regression of Melanomas and Melanocytic Naevi.
abstract: The aim of this study was to determine the clinical, histological and/or immunohistochemical features that enable differential diagnosis of regression of melanocytic naevi from regression of melanomas. All melanocytic neoplasms with histologically-confirmed regression diagnosed in our hospital between 2002 and 2009 were reviewed retrospectively. Lamellar and delicate fibrosis were associated with melanocytic naevi (p <0.0001 and p = 0.021, respectively). Compact fibrosis, high vessel density and higher number of granzyme B+ lymphocytes were associated with malignant melanoma (p = 0.011, p = 0.005 and p = 0.013, respectively). Density of inflammatory infiltrate (p = 0.016), vascular proliferation (p = 0.005), epidermal atrophy (p = 0.009), rate of apoptosis (p = 0.046) and granzyme B immunoreactivity (p = 0.013) was more common in severe-dysplastic naevi and melanomas than in the remaining melanocytic naevi. Logistic regression demonstrates that 5 variables (age, lamellar fibrosis, melanophages, vessel density, and granzyme B immunostaining) would serve to classify appropriately 87% of melanomas among melanocytic lesions with complete regression.
authors.affiliation: Department of Dermatology, Hospital Clínico Universitario Avda. Blasco Ibáñez 17, ES-46010 Valencia, Spain. Martin.josemaria@gmail.com.
authors.forename: José M
authors.initials: JM
authors.lastname: Martín
authors.forename: Isabel
authors.initials: I
authors.lastname: Pinazo
authors.forename: Esperanza
authors.initials: E
authors.lastname: Jordá
authors.forename: Carlos
authors.initials: C
authors.lastname: Monteagudo
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D001284:Atrophy; D014408:Biomarkers, Tumor / Q000032:analysis; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis; D053804:Granzymes / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D016015:Logistic Models; D008297:Male; D008545:Melanoma / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous; D009389:Neovascularization, Pathologic; D009508:Nevus, Pigmented / Q000737:chemistry / Q000473:pathology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C509213:GZMB protein, human; D053804:Granzymes