title: Necrotizing hepatitis associated withClostridium novyiin a pony in western Canada.
abstract: Severe icterus, peritoneal effusion, localized fibrinous peritonitis, and necrotizing hepatitis were found at necropsy of a 20-year-old female pony with a history of acute onset depression, inappetence, fever, and marked elevation in hepatic enzymes. Gross pathology, histopathology, and immunohistochemistry were compatible with a diagnosis of clostridial hepatitis caused byClostridium novyi-group bacteria. This is believed to be the first reported case of clostridial hepatitis in an equid in Canada, and only the third report of this rare disease in North America.
authors.affiliation: Diagnostic Services Unit (Davies) and Department of Veterinary Clinical and Diagnostic Sciences (Whitehead), University of Calgary Faculty of Veterinary Medicine, 11877 85th Street NW, Calgary, Alberta T3R 1J3; California Animal Health and Food Safety Laboratory, Faculty of Veterinary Medicine, University of California-Davis, 105 West Central Avenue, San Bernardino, California 92408, USA (Uzal).
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Davies
authors.affiliation: Diagnostic Services Unit (Davies) and Department of Veterinary Clinical and Diagnostic Sciences (Whitehead), University of Calgary Faculty of Veterinary Medicine, 11877 85th Street NW, Calgary, Alberta T3R 1J3; California Animal Health and Food Safety Laboratory, Faculty of Veterinary Medicine, University of California-Davis, 105 West Central Avenue, San Bernardino, California 92408, USA (Uzal).
authors.forename: Francesco A
authors.initials: FA
authors.lastname: Uzal
authors.affiliation: Diagnostic Services Unit (Davies) and Department of Veterinary Clinical and Diagnostic Sciences (Whitehead), University of Calgary Faculty of Veterinary Medicine, 11877 85th Street NW, Calgary, Alberta T3R 1J3; California Animal Health and Food Safety Laboratory, Faculty of Veterinary Medicine, University of California-Davis, 105 West Central Avenue, San Bernardino, California 92408, USA (Uzal).
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Whitehead
mesh_terms: D000818:Animals; D002170:Canada / Q000453:epidemiology; D003013:Clostridium / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D006520:Hepatitis, Animal / Q000453:epidemiology / Q000382:microbiology*; D006734:Horse Diseases / Q000382:microbiology*; D006736:Horses