title: Dengue-associated hemophagocytic lymphohistiocytosis in an adult: A case report and literature review.
abstract: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand.
  
  
  
  A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized.
  
  
  
  It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.
authors.affiliation: Division of Infectious Disease, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul Department of Internal Medicine, Konyang University College of Medicine, Daejeon Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
authors.forename: Sang Mi
authors.initials: SM
authors.lastname: Chung
authors.forename: Joon Young
authors.initials: JY
authors.lastname: Song
authors.forename: Wonshik
authors.initials: W
authors.lastname: Kim
authors.forename: Min Joo
authors.initials: MJ
authors.lastname: Choi
authors.forename: Ji Ho
authors.initials: JH
authors.lastname: Jeon
authors.forename: Seonghui
authors.initials: S
authors.lastname: Kang
authors.forename: Eunju
authors.initials: E
authors.lastname: Jung
authors.forename: Ji Yun
authors.initials: JY
authors.lastname: Noh
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Cheong
authors.forename: Woo Joo
authors.initials: WJ
authors.lastname: Kim
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D019595:Severe Dengue / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones