title: Seafood intake, polyunsaturated fatty acids, blood mercury, and serum C-reactive protein in US National Health and Nutrition Examination Survey (2005-2006).
abstract: We examined the association between seafood consumption, mercury concentration, polyunsaturated fatty acids, selenium, and Vitamin D in relation to C-reactive protein using the cross-sectional US National Health and Nutrition Examination Survey 2005-2006. We hypothesized that seafood consumption and fatty acids will be negatively associated, and mercury will be positively associated with C-reactive protein, and that statistical adjustment for these factors will alleviate confounding thereby making these associations more apparent. The study sample included 1217 participants (706 males, 511 females) aged 16-49. Sex-stratified sample weighted multiple linear regression models revealed no associations of mercury, polyunsaturated fatty acids, fish intake, selenium, or vitamin D with serum C-reactive protein. However, when all variables were included together in one model, fish intake was associated with lower levels of CRP in females suggesting confounding in models that do not mutually adjust for seafood contaminants and nutrients. Prospective studies are needed to confirm these findings.
authors.affiliation: a Program in Public Health , Health Sciences Center, Stony Brook University , Stony Brook , NY , USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Emanuele
authors.affiliation: a Program in Public Health , Health Sciences Center, Stony Brook University , Stony Brook , NY , USA.|b Department of Family, Population and Preventive Medicine , Health Sciences Center, Stony Brook University , Stony Brook , NY , USA.
authors.forename: Jaymie
authors.initials: J
authors.lastname: Meliker
mesh_terms: D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008628:Mercury / Q000097:blood*; D008875:Middle Aged; D009749:Nutrition Surveys; D017747:Seafood / Q000032:analysis*; D012643:Selenium / Q000378:metabolism*; D014481:United States; D014807:Vitamin D / Q000378:metabolism*; D055815:Young Adult
chemical_list: D005231:Fatty Acids, Unsaturated; D014807:Vitamin D; D002097:C-Reactive Protein; D008628:Mercury; D012643:Selenium
keywords: Heart disease; PUFA; fish consumption; methylmercury; omega-3 fatty acids