title: The feasibility of NBI in patients with suspected upper airway lesions: A multicenter study.
abstract: Narrow band imaging (NBI) improves diagnosis of laryngopharyngeal cancer, but most reported NBI studies are from experienced centers. Feasibility reports on use at everyday outpatient departments are needed.
  
  
  
  Researcher-initiated, prospective, multicenter.
  
  
  
  Participating physicians were instructed in NBI technique during a 4-hour meeting. Patients underwent an examination that included endoscopy with white light (WL) high-definition (HD) TV and NBI filter in the selected time period. All suspicious lesions were biopsied. The medical records of patients with NBI negative findings were evaluated 6 months after the visit to detect all possible malignant lesions coming into view at mucosal sites. These were considered as false-negative cases, enabling long-term assess to the positive predictive value (NPV) of the protocol.
  
  
  
  We enrolled 125 patients. Of those, 84 (67.2%) were males and the median age was 65 years (range, 35-91). In analysis of the accuracy of WL HD TV and NBI against biopsy, the sensitivity and specificity of WL HD TV were 62% and 81%, respectively; and the sensitivity and specificity of NBI were 100% and 84%, respectively. The diagnostic accuracy of NBI was significantly better (P < 0.05). When analyzing medical records 6 months after the initial examination, we found three patients who had been diagnosed with a malignant lesion (NPV of NBI of 96.8%).
  
  
  
  Narrow band imaging is readily implemented in an everyday outpatient practice, and there seems to be better detection rates of dysplastic/carcinoma lesions with HD NBI compared to HD WL.
  
  
  
  2b. Laryngoscope, 127:1821-1825, 2017.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.
authors.forename: Leif J J
authors.initials: LJJ
authors.lastname: Bäck
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Turku University Hospital, Turku.
authors.forename: Jami
authors.initials: J
authors.lastname: Rekola
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Tampere University Hospital, Tampere.
authors.forename: Lassi
authors.initials: L
authors.lastname: Raittinen
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Tampere University Hospital, Tampere.
authors.forename: Elina
authors.initials: E
authors.lastname: Halme
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.
authors.forename: Petra
authors.initials: P
authors.lastname: Pietarinen
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.
authors.forename: Harri
authors.initials: H
authors.lastname: Keski-Säntti
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.
authors.forename: Leena-Maija
authors.initials: LM
authors.lastname: Aaltonen
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.
authors.forename: Antti A
authors.initials: AA
authors.lastname: Mäkitie
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Oulu University Hospital, Oulu, Finland.
authors.forename: Antti
authors.initials: A
authors.lastname: Raappana
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Oulu University Hospital, Oulu, Finland.
authors.forename: Jukka
authors.initials: J
authors.lastname: Tikanto
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Turku University Hospital, Turku.
authors.forename: Aleksi
authors.initials: A
authors.lastname: Schrey
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Turku University Hospital, Turku.
authors.forename: Reidar
authors.initials: R
authors.lastname: Grenman
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Tampere University Hospital, Tampere.
authors.forename: Jussi
authors.initials: J
authors.lastname: Laranne
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Oulu University Hospital, Oulu, Finland.
authors.forename: Petri
authors.initials: P
authors.lastname: Koivunen
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Turku University Hospital, Turku.
authors.forename: Heikki
authors.initials: H
authors.lastname: Irjala
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D062048:Narrow Band Imaging; D010610:Pharyngeal Neoplasms / Q000000981:diagnostic imaging*; D011446:Prospective Studies
keywords: Head and neck; narrow band imaging; outpatient