title: Petroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damage.
abstract: Oxidative stress has been shown to play a principal role in the pathogenesis of stress-induced gastric injury. Parsley(Petroselinum crispum)contains many antioxidants such as flavanoids, carotenoids and ascorbic acid.
  
  
  
  In this study, the histopathological and biochemical results of nutrition with a parsley-rich diet in terms of eliminating stress-induced oxidative gastric injury were evaluated.
  
  
  
  Animal experimentation.
  
  
  
  Forty male Wistar albino rats were divided into five groups: control, stress, stress + standard diet, stress + parsley-added diet and stress + lansoprazole (LPZ) groups. Subjects were exposed to 72 hours of fasting and later immobilized and exposed to the cold at +4 degrees for 8 hours to create a severe stress condition. Samples from the animals' stomachs were arranged for microscopic and biochemical examinations.
  
  
  
  Gastric mucosal injury was obvious in rats exposed to stress. The histopathologic damage score of the stress group (7.00±0.57) was higher than that of the control group (1.50±0.22) (p<0.05). Significant differences in histopathologic damage score were found between the stress and stress + parsley-added diet groups (p<0.05), the stress and stress + standard diet groups (p<0.05), and the stress and stress + LPZ groups (p<0.05). The mean tissue malondialdehyde levels of the stress + parsley-added group and the stress + LPZ group were lower than that of the stress group (p<0.05). Parsley supported the cellular antioxidant system by increasing the mean tissue glutathione level (53.31±9.50) and superoxide dismutase (15.18±1.05) and catalase (16.68±2.29) activities.
  
  
  
  Oral administration of parsley is effective in reducing stress-induced gastric injury by supporting the cellular antioxidant defence system.
authors.affiliation: Doğu Fertil IVF Center, Malatya, Turkey.
authors.forename: Ayşin
authors.initials: A
authors.lastname: Akıncı
authors.affiliation: Department of Histology and Embryology, Bezmialem Vakıf University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Mukaddes
authors.initials: M
authors.lastname: Eşrefoğlu
authors.affiliation: Department of Histology and Embryology, Bezmialem Vakıf University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Taşlıdere
authors.affiliation: Department of Chemistry, İnönü University Faculty of Science and Art, Malatya, Turkey.
authors.forename: Burhan
authors.initials: B
authors.lastname: Ateş
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D028528:Petroselinum / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar / Q000378:metabolism; D013272:Stomach Diseases / Q000188:drug therapy / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications* / Q000523:psychology
chemical_list: D000975:Antioxidants; D010936:Plant Extracts
keywords: Lansoprazole; gastric oxidative damages; parsley