title: [Treatment effects analysis of preoperative long-acting somatostatin analogs combined trans-sphenoidal endoscopic surgery for patients with growth hormone secreting pituitary macroadenomas].
abstract: Objective:To evaluate the treatment effects of preoperative long-acting somatostatin analogue (SSA) combined trans-sphenoidal endoscopic surgery for patients with growth hormone (GH)-secreting pituitary macroadenomas.Methods:Retrospective analysis was carried out on 20 patients with GH-secreting pituitary macroadenomas who were treated with preoperative SSA and trans-sphenoidal endoscopic surgery in our apartment from January 2010 to January 2016. We also selected 20 patients with only trans-sphenoidal endoscopic surgery treatment and 20 patients with preoperative SSA and non-trans-sphenoidal endoscopic surgery treatment. The changes of tumor imaging, endocrine and blood pressure before and after treatment were analysed.Results:The Gross total resection (GTR) rate of invasive GH-secreting pituitary macroadenomas of preoperative SSA combined trans-sphenoidal endoscopic surgery group (8/13) were higher than that if only trans-sphenoidal endoscopic surgery group (4/16) and preoperative SSA combined non endoscopic surgery group (1/8) (P<0.05). Meanwhile, preoperative SSA combined trans-sphenoidal endoscopic surgery group had significantly improved the GH levels, blood glucose, lipid metabolism and blood pressure levels (P<0.05).Conclusion:The trans-sphenoidal endoscopic surgery on patients with GH-secreting pituitary macroadenomas has a significant improvement on GH levels, blood glucose, lipid metabolism and blood pressure levels. Through the treatment of preoperative long-acting SSA, the gross total resection rate is higher than other two groups.
authors.affiliation: Department of neurosurgery and Endocrinology, Peking Union Medical College Hospital, Beijing 100730, China.
authors.forename: L Y
authors.initials: LY
authors.lastname: Zhang
authors.forename: K
authors.initials: K
authors.lastname: Deng
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Yao
authors.forename: H J
authors.initials: HJ
authors.lastname: Zhu
authors.forename: Z M
authors.initials: ZM
authors.lastname: Jin
authors.forename: H
authors.initials: H
authors.lastname: Pan
mesh_terms: D000236:Adenoma; D004724:Endoscopy; D013006:Growth Hormone; D006801:Humans; D010911:Pituitary Neoplasms; D012189:Retrospective Studies; D013004:Somatostatin
chemical_list: D013004:Somatostatin; D013006:Growth Hormone
keywords: Neuroendoscopy; Pituitary adenoma; Somatostatin; Treatment outcome