title: Arginine Metabolism in Myeloid Cells Shapes Innate and Adaptive Immunity.
abstract: Arginine metabolism has been a key catabolic and anabolic process throughout the evolution of the immune response. Accruing evidence indicates that arginine-catabolizing enzymes, mainly nitric oxide synthases and arginases, are closely integrated with the control of immune response under physiological and pathological conditions. Myeloid cells are major players that exploit the regulators of arginine metabolism to mediate diverse, although often opposing, immunological and functional consequences. In this article, we focus on the importance of arginine catabolism by myeloid cells in regulating innate and adaptive immunity. Revisiting this matter could result in novel therapeutic approaches by which the immunoregulatory nodes instructed by arginine metabolism can be targeted.
authors.affiliation: Augusta University, Georgia Cancer Center , Augusta, GA , USA.
authors.forename: Paulo C
authors.initials: PC
authors.lastname: Rodriguez
authors.affiliation: Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
authors.forename: Augusto C
authors.initials: AC
authors.lastname: Ochoa
authors.affiliation: Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
authors.forename: Amir A
authors.initials: AA
authors.lastname: Al-Khami
keywords: M1 and M2; MDSC; arginase; arginine; dendritic cell; immune response; macrophage; nitric oxide synthase