title: Nerve-associated neural crest: peripheral glial cells generate multiple fates in the body.
abstract: Recent studies demonstrated that neural crest-derived Schwann cell precursors (SCPs) dwelling in the nerves are multipotent and can be recruited in the local tissue to provide building blocks of neural crest-derived nature. The variety of fates produced by SCPs is widening with every year and currently includes melanocytes/melanophores, parasympathetic and enteric neurons, endoneural fibroblast, mesenchymal stem cells and, of course, mature Schwann cells of different subtypes. However, it is still unclear if SCPs are, in fact, nerve-dwelling population of the neural crest or they are rather a different, more specialized, cell type. This review outlines the field and focuses on the capacity of nerve-associated glial progenitors to contribute to the development and regeneration of numerous tissues in various groups of vertebrates.
authors.affiliation: Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.
authors.forename: Julian
authors.initials: J
authors.lastname: Petersen
authors.affiliation: Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria; Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden. Electronic address: igor.adameyko@ki.se.
authors.forename: Igor
authors.initials: I
authors.lastname: Adameyko
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002454:Cell Differentiation; D009432:Neural Crest / Q000166:cytology* / Q000502:physiology; D009457:Neuroglia / Q000166:cytology* / Q000502:physiology; D009473:Neuronal Plasticity; D009474:Neurons / Q000166:cytology / Q000502:physiology; D010525:Peripheral Nerves / Q000166:cytology* / Q000502:physiology; D012583:Schwann Cells / Q000166:cytology* / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology