title: DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential.
abstract: Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine quartets. There has been considerable recent progress in the detection and mapping of G4 structures in the human genome and in biologically relevant contexts. These advancements, many of which align with predictions made previously in computational studies, provide important new insights into the functions of G4 structures in, for example, the regulation of transcription and genome stability, and uncover their potential relevance for cancer therapy.
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Hänsel-Hertsch
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.|Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
authors.forename: Marco
authors.initials: M
authors.lastname: Di Antonio
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.|Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.|School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.
authors.forename: Shankar
authors.initials: S
authors.lastname: Balasubramanian
mesh_terms: D000818:Animals; D004261:DNA Replication; D004277:DNA, Single-Stranded / Q000737:chemistry; D054856:G-Quadruplexes; D005786:Gene Expression Regulation; D015894:Genome, Human; D042822:Genomic Instability; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D009841:Oligonucleotides; D014158:Transcription, Genetic
chemical_list: D004277:DNA, Single-Stranded; D009841:Oligonucleotides