title: Activity associated with speech articulation measured through direct cortical recordings.
abstract: The insula has been credited with a role in a number of functions, including speech production. Here, we recorded electrocorticography (ECoG) signals from the left insula during pseudoword articulation in two patients undergoing pre-surgical monitoring for the management of medically-intractable epilepsy. Event-related band power (ERBP) activity from electrodes implanted in the superior precentral gyrus of the insula (SPGI) was compared to that of other left hemisphere regions implicated in speech production. Results showed that SPGI contacts demonstrated significantly greater ERBP within the high-gamma frequency range (75-150Hz) during articulation compared to a listening condition. However, frontal and post-central regions demonstrated significantly greater responses to the articulation task compared to the SPGI. Results suggest the SPGI is active during articulation, but frontal and post-central regions demonstrate significantly more robust responses. Given the small sample size, and number of electrodes implanted in the SPGI, further study is warranted to confirm these findings.
authors.affiliation: Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, United States.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Basilakos
authors.affiliation: Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, United States.
authors.forename: Julius
authors.initials: J
authors.lastname: Fridriksson
authors.affiliation: Department of Psychology, University of South Carolina, Columbia, SC 29208, United States.
authors.forename: Chris
authors.initials: C
authors.lastname: Rorden
authors.affiliation: Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, United States.
authors.forename: Roozbeh
authors.initials: R
authors.lastname: Behroozmand
authors.affiliation: Department of Psychology, University of South Carolina, Columbia, SC 29208, United States.
authors.forename: Taylor
authors.initials: T
authors.lastname: Hanayik
authors.affiliation: Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, United States.
authors.forename: Thomas
authors.initials: T
authors.lastname: Naselaris
authors.affiliation: Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, United States.
authors.forename: John
authors.initials: J
authors.lastname: Del Gaizo
authors.affiliation: Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, United States.
authors.forename: Jesse
authors.initials: J
authors.lastname: Breedlove
authors.affiliation: Department of Neurosurgery, Medical University of South Carolina, Charleston, SC 29425, United States.
authors.forename: W A
authors.initials: WA
authors.lastname: Vandergrift
authors.affiliation: Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, United States. Electronic address: bonilha@musc.edu.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Bonilha
mesh_terms: D000328:Adult; D001307:Auditory Perception / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D006801:Humans; D018401:Sample Size; D013060:Speech / Q000502:physiology*
keywords: Articulation; Electrocorticography; Insula; Speech production