title: Isoafricanol synthase from Streptomyces malaysiensis.
abstract: Genome sequencing of Streptomyces malaysiensis DSM 4137 revealed the presence of four terpene cyclase genes, one of which was characterised as (+)-isoafricanol synthase. Its cyclisation mechanism was extensively studied using isotopically labelled precursors. Several enzymes with high homology that likely also function as (+)-isoafricanol synthases are encoded in a number of other genome sequenced streptomycetes.
authors.affiliation: Kekulé-Institut für Organische Chemie und Biochemie, Rheinische Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Straße 1, 53121 Bonn, Germany. dickschat@uni-bonn.de.
authors.forename: Patrick
authors.initials: P
authors.lastname: Rabe
authors.forename: Markiyan
authors.initials: M
authors.lastname: Samborskyy
authors.forename: Peter F
authors.initials: PF
authors.lastname: Leadlay
authors.forename: Jeroen S
authors.initials: JS
authors.lastname: Dickschat
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000235:genetics / Q000378:metabolism*; D008968:Molecular Conformation; D013302:Streptomyces / Q000201:enzymology*
chemical_list: D019883:Alkyl and Aryl Transferases