title: Applanation optical coherence elastography: noncontact measurement of intraocular pressure, corneal biomechanical properties, and corneal geometry with a single instrument.
abstract: Current clinical tools provide critical information about ocular health such as intraocular pressure (IOP). However, they lack the ability to quantify tissue material properties, which are potent markers for ocular tissue health and integrity. We describe a single instrument to measure the eye-globe IOP, quantify corneal biomechanical properties, and measure corneal geometry with a technique termed applanation optical coherence elastography (Appl-OCE). An ultrafast OCT system enabled visualization of corneal dynamics during noncontact applanation tonometry and direct measurement of micro air-pulse induced elastic wave propagation. Our preliminary results show that the proposed Appl-OCE system can be used to quantify IOP, corneal biomechanical properties, and corneal geometry, which builds a solid foundation for a unique device that can provide a more complete picture of ocular health.
authors.affiliation: University of Houston, Department of Biomedical Engineering, Houston, Texas, United States.
authors.forename: Manmohan
authors.initials: M
authors.lastname: Singh
authors.affiliation: University of Houston, Department of Biomedical Engineering, Houston, Texas, United States.
authors.forename: Zhaolong
authors.initials: Z
authors.lastname: Han
authors.affiliation: University of Houston, Department of Biomedical Engineering, Houston, Texas, United States.
authors.forename: Achuth
authors.initials: A
authors.lastname: Nair
authors.affiliation: University of Houston, Department of Biomedical Engineering, Houston, Texas, United States.
authors.forename: Alexander
authors.initials: A
authors.lastname: Schill
authors.affiliation: University of Alabama at Birmingham, School of Optometry, Birmingham, Alabama, United States.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Twa
authors.affiliation: University of Houston, Department of Biomedical Engineering, Houston, Texas, United StatescTomsk State University, Interdisciplinary Laboratory of Biophotonics, Tomsk, RussiadBaylor College of Medicine, Molecular Physiology and Biophysics, Houston, Texas, United States.
authors.forename: Kirill V
authors.initials: KV
authors.lastname: Larin
mesh_terms: D001696:Biomechanical Phenomena; D003315:Cornea / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology*; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation*; D054459:Elasticity Imaging Techniques; D005128:Eye Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D007429:Intraocular Pressure; D014065:Tonometry, Ocular / Q000295:instrumentation