title: Effectiveness of pre-treatment with chlorhexidine in restoration retention: A 36-month follow-up randomized clinical trial.
abstract: OBJECTIVE
  This study evaluated the effect of the pre-treatment with 2% chlorhexidine digluconate (CHX) as coadjutant in restoration retention of noncarious cervical lesions (NCCL), after 36 months of follow-up.
  
  
  METHODS
  A randomized controlled split-mouth and triple-blind (operators, patients and evaluator) trial was carried out. Patients (n=42) with at least two non-carious cervical lesions were included. The teeth with NCCL were randomly assigned to two treatment groups: application of 2% CHX (experimental group) or a placebo solution (control group) for 60s after acid etching and before the adhesive application. A trained and calibrated examiner evaluated the restorations at baseline (1 week) and at each recall (6, 12, 24 and 36 months) using the FDI criteria. A total of 225 restorations were evaluated after 36-month follow-up. Data were subjected to survival analysis using the Kaplan-Meier method, and the log-rank test was used to evaluate the existence of differences between the survival curves (α=0.05).
  
  
  RESULTS
  The restorations survival rate after 36 months of follow-up was 76.1%. There was no difference in the retention and failure rates between the experimental and the control group (p=0.968). There was an increased failure trend when restorations were located subgingival compared to those at the gingival level or supragingival.
  
  
  CONCLUSIONS
  The pre-treatment with 2% chlorhexidine digluconate did not promote further restoration retention of noncarious cervical lesions.
  
  
  CONCLUSIONS
  The cavity pre-treatment with chlorhexidine for inhibition of hybrid layer degradation does not add any beneficial effect to the clinical performance of restorations.
authors.affiliation: Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Brazil.
authors.forename: Morgana
authors.initials: M
authors.lastname: Favetti
authors.affiliation: Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Brazil.
authors.forename: Thaiane
authors.initials: T
authors.lastname: Schroeder
authors.affiliation: Graduate Program in Dentistry, School of Dentistry, Federal University of Santa Maria, Brazil.
authors.forename: Anelise Fernandes
authors.initials: AF
authors.lastname: Montagner
authors.affiliation: Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Brazil.
authors.forename: Marcos Britto
authors.initials: MB
authors.lastname: Correa
authors.affiliation: Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Brazil.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Pereira-Cenci
authors.affiliation: Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Brazil. Electronic address: cencims@gmail.com.
authors.forename: Maximiliano Sergio
authors.initials: MS
authors.lastname: Cenci
mesh_terms: D002710:Chlorhexidine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003188:Composite Resins / Q000627:therapeutic use*; D001840:Dental Bonding / Q000379:methods; D003738:Dental Cements; D003764:Dental Materials / Q000627:therapeutic use; D019232:Dental Restoration Failure; D003793:Dental Restoration, Permanent / Q000145:classification; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010919:Placebos; D013997:Time Factors; D019237:Tooth Cervix / Q000473:pathology; D057085:Tooth Wear / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D003188:Composite Resins; D003738:Dental Cements; D003764:Dental Materials; D010919:Placebos; C010882:chlorhexidine gluconate; D002710:Chlorhexidine
keywords: Adhesive system; Chlorhexidine; Dental restoration; MMP inhibitor; Noncarious cervical lesions; Randomized controlled trial