title: The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy.
abstract: Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out. The area of the cortical matter in the thymus decreased 6 months after carcinogenesis induction, the percentage of connective tissue elements and glandular tissue and the counts of immunoblasts and cells with pyknotic nuclei increased, this indicating the development of accidental involution of the thymus. Animals of the experimental tumor+chemotherapy group exhibited morphological signs of lymphocyte migration from the thymus and suppressed activities of the lymphoid and epithelial components (lesser area of connective tissue elements and glandular tissue, lesser density of parenchymatous cell elements, lesser counts of immunoblasts and small lymphocytes, and larger area of the medulla) in comparison with animals without chemotherapy.
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia. kazakoff_oleg@mail.ru.
authors.forename: O V
authors.initials: OV
authors.lastname: Kazakov
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kabakov
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Ishchenko
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: A F
authors.initials: AF
authors.lastname: Poveshchenko
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Raiter
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: D N
authors.initials: DN
authors.lastname: Strunkin
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Michurina
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Konenkov
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D063646:Carcinogenesis / Q000187:drug effects*; D002273:Carcinogens / Q000633:toxicity; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology; D008264:Macrophages / Q000187:drug effects / Q000473:pathology; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000473:pathology; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008727:Methotrexate / Q000008:administration & dosage; D008770:Methylnitrosourea / Q000633:toxicity; D017208:Rats, Wistar; D013950:Thymus Gland / Q000187:drug effects* / Q000473:pathology; D013953:Thymus Neoplasms / Q000188:drug therapy* / Q000556:secondary
chemical_list: D002273:Carcinogens; D008770:Methylnitrosourea; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
keywords: lymphocytes; mammary tumor; thymus