title: Changes in Histidine Decarboxylase, Histamine N-Methyltransferase and Histamine Receptors in Neuropsychiatric Disorders.
abstract: Compared to other monoamine neurotransmitters, information on the association between the histaminergic system and neuropsychiatric disorders is scarce, resulting in a lack of histamine-related treatment for these disorders. The current chapter tries to combine information obtained from genetic studies, neuroimaging, post-mortem human brain studies and cerebrospinal fluid measurements with data from recent clinical trials on histamine receptor agonists and antagonists, with a view to determining the possible role of the histaminergic system in neuropsychiatric disorders and to pave the way for novel histamine-related therapeutic strategies.
authors.affiliation: Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China.|Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, University of Amsterdam, Meibergdreef 47, Amsterdam, 1105 BA, The Netherlands.
authors.forename: Ling
authors.initials: L
authors.lastname: Shan
authors.affiliation: Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China. baoaimin@zju.edu.cn.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Bao
authors.affiliation: Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, University of Amsterdam, Meibergdreef 47, Amsterdam, 1105 BA, The Netherlands. d.f.swaab@nin.knaw.nl.
authors.forename: Dick F
authors.initials: DF
authors.lastname: Swaab
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D006632:Histamine / Q000378:metabolism; D006637:Histamine N-Methyltransferase / Q000378:metabolism*; D006640:Histidine Decarboxylase / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000378:metabolism*; D058027:Neuropsychiatry / Q000379:methods; D011968:Receptors, Histamine / Q000378:metabolism*
chemical_list: D011968:Receptors, Histamine; D006632:Histamine; D006637:Histamine N-Methyltransferase; D006640:Histidine Decarboxylase
keywords: Histamine; Histamine N-methyltransferase; Histamine receptors; Histidine decarboxylase; Intellectual disability; Mood disorders; Neurodegenerative diseases