title: Synthesis of Arylated Nucleobases by Visible Light Photoredox Catalysis.
abstract: Arylated nucleobases were synthesized by visible light photocatalysis using rhodamine 6G as photoredox catalyst and N,N-diisopropylethylamine as sacrificial electron donor. The high redox potential of this catalyst system is achieved by a consecutive photoinduced electron transfer process (conPET) and allows the room temperature conversion of brominated and chlorinated nucleobases or nucleobase precursors as starting materials. In contrast to many transition-metal-based syntheses, a direct C-H arylation of nitrogen-containing halogenated heterocycles is possible without protection of the N-H groups. The method provides a simple, metal-free alternative for the synthesis of biologically interesting arylated heterocycles under mild conditions.
authors.affiliation: Institut für Organische Chemie, Universität Regensburg , Universitätsstrasse 31, D-93053 Regensburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Graml
authors.affiliation: Institut für Organische Chemie, Universität Regensburg , Universitätsstrasse 31, D-93053 Regensburg, Germany.
authors.forename: Indrajit
authors.initials: I
authors.lastname: Ghosh
authors.affiliation: Institut für Organische Chemie, Universität Regensburg , Universitätsstrasse 31, D-93053 Regensburg, Germany.
authors.forename: Burkhard
authors.identifier: 0000-0002-6131-4850
authors.initials: B
authors.lastname: König