title: Protective effect of curcumin against myocardium injury in ischemia reperfusion rats.
abstract: BACKGROUND
  Curcumin has long been used as a condiment and a traditional medicine worldwide.
  
  
  OBJECTIVE
  The current study investigates the possible protective effect of curcumin on heart function in myocardium ischemia-reperfusion (MIR) rats.
  
  
  METHODS
  We fed Sprague-Dawley (SD) rats (10 in each group) either curcumin (10, 20 or 30 mg/kg/d) or saline. Twenty days later, the rats were subjected to myocardial injuries by ligating the left anterior descending coronary artery (60 min), and subsequently, the heart (3 h) reperfused by releasing the ligation. Then, lipid profile, lipid peroxidation products, antioxidant enzymes and gene expression were assessed in myocardium tissue.
  
  
  RESULTS
  Only the rats that were supplemented with curcumin (10, 20 or 30 mg/kg/d) showed significant (p < 0.05) reductions in oxidative stress (3-fold), infarct size (2.5-fold), which was smaller than that of the control group. The percentage of infarct size in MIR rats with curcumin at 10, 20 or 30 mg/kg/d decreased (from 49.1% to 18.3%) compared to ischemia-reperfusion (I/R). The enhanced phosphorylation of STAT3 was further strengthened by curcumin (10, 20 or 30 mg/kg/d) in a dose-dependent manner.
  
  
  CONCLUSIONS
  Curcumin intake might reduce the risk of coronary heart disease by stimulating JAK2/STAT3 signal pathway, decreasing oxidative damage and inhibiting myocardium apoptosis.
authors.affiliation: a Shanghai Tenth Clinical Medical School of Nanjing Medical University , Shanghai , China.
authors.forename: HuaJin
authors.initials: H
authors.lastname: Liu
authors.affiliation: b Tengzhou Central People?s Hospital , Tengzhou , China.
authors.forename: ChangHua
authors.initials: C
authors.lastname: Wang
authors.affiliation: a Shanghai Tenth Clinical Medical School of Nanjing Medical University , Shanghai , China.
authors.forename: Zengyong
authors.initials: Z
authors.lastname: Qiao
authors.affiliation: a Shanghai Tenth Clinical Medical School of Nanjing Medical University , Shanghai , China.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D003474:Curcumin / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D053614:Janus Kinase 2 / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D018384:Oxidative Stress / Q000187:drug effects; D010766:Phosphorylation; D017207:Rats, Sprague-Dawley; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D016277:Ventricular Function, Left; D017725:Ventricular Pressure / Q000187:drug effects
chemical_list: D000975:Antioxidants; D051017:Apoptosis Regulatory Proteins; D050796:STAT3 Transcription Factor; C494088:Stat3 protein, rat; C507927:Jak2 protein, rat; D053614:Janus Kinase 2; D003474:Curcumin
keywords: Blood lipid; antioxidant; immunity; signal pathway