title: GGNBP2 Suppresses the Proliferation, Invasion, and Migration of Human Glioma Cells.
abstract: Gliomas are the most common and aggressive type of primary adult brain tumors. Although GGNBP2 has previously been considered to be a tumor suppressor gene, little is known about the association between GGNBP2 and glioma. In this study, we clearly demonstrated that GGNBP2 was downexpressed in glioma tissues, and its downexpression is related to the pathological grade and overall survival of patients with gliomas. Overexpression of GGNBP2 suppressed the proliferation, migration, and invasion of glioma cells. Mechanistically, we demonstrated that the PI3K/Akt and Wnt/β-catenin signaling pathways were suppressed by GGNBP2 overexpression. In contrast, knockdown of GGNBP2 has precisely the opposite effect. Collectively, these data indicate that GGNBP2 shows tumor suppressive activity in human glioma cells and may stand out as a potential therapeutic target for glioma.
authors.forename: Ao
authors.initials: A
authors.lastname: Zhan
authors.forename: Bo
authors.initials: B
authors.lastname: Lei
authors.forename: Honggang
authors.initials: H
authors.lastname: Wu
authors.forename: YueTao
authors.initials: Y
authors.lastname: Wen
authors.forename: Liandong
authors.initials: L
authors.lastname: Zheng
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Wan
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Wei
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D015870:Gene Expression; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D060449:Wnt Signaling Pathway
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D025521:Tumor Suppressor Proteins; C487856:GGNBP2 protein, human