title: Serological evidence for exposure to avian influenza viruses within poultry workers in southern China.
abstract: The risk of infection with avian influenza viruses for poultry workers is relatively unknown in China, and study results are often biased by the notification of only the severe human cases. Protein microarray was used to detect binding antibodies to 13 different haemagglutinin (HA1-part) antigens of avian influenza A(H5N1), A(H7N7), A(H7N9) and A(H9N2) viruses, in serum samples from poultry workers and healthy blood donors collected in the course of 3 years in Guangdong Province, China. Significantly higher antibody titre levels were detected in poultry workers when compared to blood donors for the most recent H5 and H9 strains tested. These differences were most pronounced in younger age groups for antigens from older strains, but were observed in all age groups for the recent H5 and H9 antigens. For the H7 strains tested, only poultry workers from two retail live poultry markets had significantly higher antibody titres compared to blood donors.
authors.affiliation: Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.|Laboratory for Infectious Diseases and Perinatal Screening, Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
authors.forename: E
authors.identifier: 0000-0003-0826-5102
authors.initials: E
authors.lastname: de Bruin
authors.affiliation: Guangdong Province Center for Disease Control and Prevention, Panyu District, Guangzhou, Guangdong, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Guangdong Province Center for Disease Control and Prevention, Panyu District, Guangzhou, Guangdong, China.
authors.forename: C
authors.initials: C
authors.lastname: Ke
authors.affiliation: Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.|Laboratory for Infectious Diseases and Perinatal Screening, Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Sikkema
authors.affiliation: Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.|Laboratory for Infectious Diseases and Perinatal Screening, Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Koopmans
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001782:Blood Donors; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D009980:Influenza A virus / Q000302:isolation & purification*; D005585:Influenza in Birds / Q000453:epidemiology / Q000821:virology*; D007251:Influenza, Human / Q000097:blood / Q000453:epidemiology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011200:Poultry; D040081:Protein Array Analysis; D012307:Risk Factors; D014764:Viral Proteins / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D014764:Viral Proteins
keywords: China; H5N1 virus; H7N9 virus; H9N2 virus; protein microarrays; seroprevalence