title: [Correlation of Th17 Cells and IL-17 Level in Multiple Myeloma Patients with Pathogenesis of Multiple Myeloma].
abstract: OBJECTIVE
  To explore the correlation of Th17 cell rate and IL-17 level with pathogenetis of multiple myeloma(MM).
  
  
  METHODS
  Forty-five cases of MM were enrolled in MM group, while 45 healthy volunteers were selected in control group. The rate of Th17 cells, levels of IL-17 and β2-microglobulin(β2-MG) in patients subgrouping according to ISS staging and treatment were detected by using flow cytometer and IL-17 assay kit. The correlation of Th17 cell rate and IL-17 level with MM was analyzed.
  
  
  RESULTS
  The rate of Th17 cells and level of IL-17 in MM group were higher than those in control group(P<0.05), the rate of Th17 cells and level of IL-17 in ISS III stage patients were higher than those in ISS I and II stage patients(P<0.05); the rate of Th17 cells and level of IL-17 in ISS I and ISS II stage patients were not significant difference (P>0.05); the rate of Th17 cells and level of IL-17 in firstly treated, retreated/refractory patients were significantly higher than those in patients with effective treatment(P<0.05), while the rate of Th17 cells and level of IL-17 between firstly treated patients and retreated/refractory patients were not significant difference (P>0.05). The Th17 rate and IL-17 level in MM patients positively correlated with β2-MG level (r=0.422, r=0.416, P<0.05).
  
  
  CONCLUSIONS
  The obvious increase of Th17 rate, IL-17 and β2-MG levels closely relates with pathogenesis of MM. The Th17 rate and IL-17 level may be used as important evidence for evaluation of ISS stage and therapeutic efficacy of MM.
authors.affiliation: Department of Hematology, The Center Hospital of Nanyang, Nanyang 473001, Henan Province, China.
authors.forename: Chao-Yang
authors.initials: CY
authors.lastname: DU
authors.affiliation: Department of Hematology, The Center Hospital of Nanyang, Nanyang 473001, Henan Province, China. E-mail: doctor681@163.com.
authors.forename: Ru-Yu
authors.initials: RY
authors.lastname: Yang
authors.affiliation: Department of Hematology, The Center Hospital of Nanyang, Nanyang 473001, Henan Province, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Hematology, The Center Hospital of Nanyang, Nanyang 473001, Henan Province, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Duan
mesh_terms: D005434:Flow Cytometry; D006801:Humans; D020381:Interleukin-17 / Q000032:analysis*; D009101:Multiple Myeloma / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D058504:Th17 Cells
chemical_list: D020381:Interleukin-17