title: Serum uric acid and the relationship with subclinical organ damage in adults.
abstract: Elevated serum uric acid (SUA) is often present in conditions associated with increased cardiovascular risk yet it is not recognized as a marker of risk. We evaluated whether SUA was associated with evidence of early markers of cardiovascular risk factor including subclinical early organ damage, sympathetic tone and metabolic profile in a healthy population with a high prevalence of obesity.
  
  
  
  Data from 281 patients (175 women and 106 men, mean age: 35.5 ± 0.8 years, mean BMI: 33.2 ± 0.5 kg/m) were retrieved from a database. All participants were healthy, nonsmoker and free of medication. Available data included metabolic profile, muscle sympathetic nervous activity (MSNA, microneurography), endothelial function (pulse amplitude tonometry, augmentation index), estimated glomerular filtration rate (eGFR) and echocardiography.
  
  
  
  With participants grouped into sex-adjusted tertiles of SUA, those in the third tertile of SUA had increased waist circumference, worse metabolic profile (fasting glucose, total cholesterol, triglycerides and HDL), elevated MSNA, decreased endothelial function, increased augmentation index and decreased eGFR compared with those in the first tertile of SUA. In multiple regression analysis adjusted for age, sex, BMI and ethnicity, SUA was independently associated with waist circumference, low-density lipoprotein, triglycerides, augmentation index, MSNA and eGFR, providing a combined adjusted R = 0.599 or 60% of the overall variance.
  
  
  
  In a healthy population with a high proportion of obesity, SUA is associated with measures of metabolic, end-organ damage and sympathetic tone indicating the potential value of SUA as a marker of early cardiovascular disease development.
authors.affiliation: aHuman Neurotransmitters Laboratory, Baker IDI Heart & Diabetes Institute bDepartment of Physiology, Monash University, Melbourne, Victoria cRoyal Perth Hospital Unit, School of Medicine and Pharmacology, Perth, Western Australia dFaculty of Medicine, Nursing and Health Sciences eDepartment of General Practice, Monash University, Melbourne, Victoria, Australia.
authors.forename: Elisabeth A
authors.initials: EA
authors.lastname: Lambert
authors.forename: Mariam
authors.initials: M
authors.lastname: Hachem
authors.forename: Robyn
authors.initials: R
authors.lastname: Hemmes
authors.forename: Nora E
authors.initials: NE
authors.lastname: Straznicky
authors.forename: Nina
authors.initials: N
authors.lastname: Eikelis
authors.forename: Carolina I
authors.initials: CI
authors.lastname: Sari
authors.forename: Markus P
authors.initials: MP
authors.lastname: Schlaich
authors.forename: Gavin W
authors.initials: GW
authors.lastname: Lambert
authors.forename: John B
authors.initials: JB
authors.lastname: Dixon
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D014280:Triglycerides; D014527:Uric Acid; D002784:Cholesterol