title: Fabrication and in vitro biological properties of piezoelectric bioceramics for bone regeneration.
abstract: The piezoelectric effect of biological piezoelectric materials promotes bone growth. However, the material should be subjected to stress before it can produce an electric charge that promotes bone repair and reconstruction conducive to fracture healing. A novel method for in vitro experimentation of biological piezoelectric materials with physiological load is presented. A dynamic loading device that can simulate the force of human motion and provide periodic load to piezoelectric materials when co-cultured with cells was designed to obtain a realistic expression of piezoelectric effect on bone repair. Hydroxyapatite (HA)/barium titanate (BaTiO3) composite materials were fabricated by slip casting, and their piezoelectric properties were obtained by polarization. The d33of HA/BaTiO3piezoelectric ceramics after polarization was 1.3 pC/N to 6.8 pC/N with BaTiO3content ranging from 80% to 100%. The in vitro biological properties of piezoelectric bioceramics with and without cycle loading were investigated. When HA/BaTiO3piezoelectric bioceramics were affected by cycle loading, the piezoelectric effect of BaTiO3promoted the growth of osteoblasts and interaction with HA, which was better than the effect of HA alone. The best biocompatibility and bone-inducing activity were demonstrated by the 10%HA/90%BaTiO3piezoelectric ceramics.
authors.affiliation: Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an 710048, PR China.
authors.forename: Yufei
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an 710048, PR China.
authors.forename: Cong
authors.initials: C
authors.lastname: Wu
authors.affiliation: Institute of Orthopaedics, Xi'jing Hospital, The Fourth Military Medical University, Xi'an 710032, PR China.
authors.forename: Zixiang
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an 710048, PR China.
authors.forename: Long
authors.initials: L
authors.lastname: Hu
authors.affiliation: Institute of Orthopaedics, Xi'jing Hospital, The Fourth Military Medical University, Xi'an 710032, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an 710048, PR China.
authors.forename: Kang
authors.initials: K
authors.lastname: Zhao
mesh_terms: D017609:Barium Compounds / Q000737:chemistry / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D001696:Biomechanical Phenomena; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology*; D001842:Bone and Bones / Q000293:injuries; D002460:Cell Line; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology*; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology*; D004560:Electricity; D055664:Electrochemical Techniques; D006801:Humans; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D017609:Barium Compounds; D001672:Biocompatible Materials; D018786:Bone Substitutes; C024547:barium titanate(IV); D017886:Durapatite; D014025:Titanium