title: Combination therapy with vedolizumab and etanercept in a patient with pouchitis and spondylarthritis.
abstract: Inflammatory bowel disease is frequently associated with spondylarthritis (SpA). It has been discussed that α4/β7 expressing lymphocytes are involved in the aetiology of SpA. We report a case of a successful combination therapy of vedolizumab (VDZ) and etanercept (ETA) in a patient with ulcerative colitis with pouchitis and SpA. In our case VDZ was effective for pouchitis and ineffective for SpA. The combination with ETA might be a useful treatment strategy to control both diseases and first indications suggest that it is safe. α4/β7 Expressing lymphocytes are most likely not associated in the aetiology of SpA.
authors.affiliation: Medical Department I, Gastroenterology , University Medical Center, Schleswig Holstein, Campus Kiel , Kiel , Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Bethge
authors.affiliation: Medical Department I, Gastroenterology , University Medical Center, Schleswig Holstein, Campus Kiel , Kiel , Germany.
authors.forename: Silvia
authors.initials: S
authors.lastname: Meffert
authors.affiliation: Medical Department I, Gastroenterology , University Medical Center, Schleswig Holstein, Campus Kiel , Kiel , Germany.
authors.forename: Mark
authors.initials: M
authors.lastname: Ellrichmann
authors.affiliation: Medical Department I, Gastroenterology , University Medical Center, Schleswig Holstein, Campus Kiel , Kiel , Germany.
authors.forename: Claudio
authors.initials: C
authors.lastname: Conrad
authors.affiliation: Medical Department I, Gastroenterology , University Medical Center, Schleswig Holstein, Campus Kiel , Kiel , Germany.
authors.forename: Susanna
authors.initials: S
authors.lastname: Nikolaus
authors.affiliation: Medical Department I, Gastroenterology , University Medical Center, Schleswig Holstein, Campus Kiel , Kiel , Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Schreiber
keywords: INFLAMMATORY BOWEL DISEASE; INTEGRINS; SPONDYLOARTHROPATHY; TNF-ALPHA