title: Individual Biomarkers Using Molecular Personalized Medicine Approaches.
abstract: Molecular personalized medicine tries to generate individual predictive biomarkers to assist doctors in their decision making. These are thought to improve the efficacy and lower the toxicity of a treatment. The molecular basis of the desired high-precision prediction is modern "omex" technologies providing high-throughput bioanalytical methods. These include genomics and epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, imaging, and functional analyses. In most cases, producing big data also requires a complex biomathematical analysis. Using molecular personalized medicine, the conventional physician's check of biomarker results may no longer be sufficient. By contrast, the physician may need to cooperate with the biomathematician to achieve the desired prediction on the basis of the analysis of individual big data typically produced by omex technologies. Identification of individual biomarkers using molecular personalized medicine approaches is thought to allow a decision-making for the precise use of a targeted therapy, selecting the successful therapeutic tool from a panel of preexisting drugs or medical products. This should avoid the treatment of nonresponders and responders that produces intolerable unwanted effects.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen, Germany.
authors.forename: Hans P
authors.initials: HP
authors.lastname: Zenner
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D000066491:Clinical Decision-Making; D005260:Female; D005544:Forecasting; D005858:Germany; D006801:Humans; D008297:Male; D055432:Metabolomics / Q000379:methods; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D040901:Proteomics; D016032:Randomized Controlled Trials as Topic; D006113:United Kingdom; D014481:United States
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D011505:Protein-Tyrosine Kinases