title: Diels-Alder reactions of myrcene using intensified continuous-flow reactors.
abstract: This work describes the Diels-Alder reaction of the naturally occurring substituted butadiene, myrcene, with a range of different naturally occurring and synthetic dienophiles. The synthesis of the Diels-Alder adduct from myrcene and acrylic acid, containing surfactant properties, was scaled-up in a plate-type continuous-flow reactor with a volume of 105 mL to a throughput of 2.79 kg of the final product per day. This continuous-flow approach provides a facile alternative scale-up route to conventional batch processing, and it helps to intensify the synthesis protocol by applying higher reaction temperatures and shorter reaction times.
authors.affiliation: CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia.
authors.forename: Christian H
authors.initials: CH
authors.lastname: Hornung
authors.affiliation: CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia.
authors.forename: Miguel Á
authors.initials: MÁ
authors.lastname: Álvarez-Diéguez
authors.affiliation: CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Kohl
authors.affiliation: CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Tsanaktsidis
keywords: continuous processing; flow chemistry; renewable feedstock; surfactant