title: NPY1Receptors Participate in the Regulation of Myocardial Contractility in Rats.
abstract: Selective agonist (Leu(31)Pro(34)NPY) and blocker (BIBP-3226) of NPY1 receptors were used to determine the type of NPY receptors involved in myocardial contraction. Experiments with isometric contraction of myocardial strips from mature rats showed that the agonist produced the most potent effect in a concentration of 10-7M. In this concentration, Leu(31)Pro(34)NPY showed the greatest positive inotropic effect on the contraction of the atria and ventricles. In contrast, selective blocker BIBP-3226 reduced the force of myocardial contractions. Pretreatment of myocardial strips with this blocker abolished the positive inotropic effect of Leu(31)Pro(34)NPY, which attested to important role of NPY1receptors in myocardial contraction.
authors.affiliation: Department of Normal Physiology and Biophysics, Yaroslavl State Medical University, Yaroslavl, Russia.
authors.forename: P M
authors.initials: PM
authors.lastname: Masliuko
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Anikina
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia. alekcei5@rambler.ru.
authors.forename: A A
authors.initials: AA
authors.lastname: Zverev
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Krylova
authors.affiliation: Department of Normal Physiology and Biophysics, Yaroslavl State Medical University, Yaroslavl, Russia.
authors.forename: K Yu
authors.initials: KY
authors.lastname: Moiseev
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia.
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism; D007537:Isometric Contraction / Q000187:drug effects* / Q000502:physiology; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D009478:Neuropeptide Y / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018013:Receptors, Neuropeptide / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D046509:Tissue Culture Techniques
chemical_list: C092926:BIBP 3226; D002316:Cardiotonic Agents; D009478:Neuropeptide Y; C066211:Npy1r protein, rat; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide; C062259:neuropeptide Y, Leu(31)-Pro(34)-; D001120:Arginine
keywords: myocardial contractility; neuropeptide Y; rat; types of NPY receptors