title: Synthesis of Indolines by a Zn-Mediated Mannich Reaction/Pd-Catalyzed Amination Sequence.
abstract: 1,2-Disubstituted indolines have been prepared in fair to good yields by a Zn-mediated organometallic Mannich reaction, followed by an intramolecular Pd-catalyzed aromatic amination. The reactions are easy to set up and compatible with a large variety of simple or commercially available reagents. The method was further extended to the preparation of a 1,2,3-trisubstituted indoline.
authors.affiliation: Électrochimie et Synthèse Organique, Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC , 2-8 rue Henri Dunant, F-94320 Thiais, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Presset
authors.affiliation: Électrochimie et Synthèse Organique, Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC , 2-8 rue Henri Dunant, F-94320 Thiais, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Pignon
authors.affiliation: Électrochimie et Synthèse Organique, Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC , 2-8 rue Henri Dunant, F-94320 Thiais, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Paul
authors.affiliation: Électrochimie et Synthèse Organique, Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC , 2-8 rue Henri Dunant, F-94320 Thiais, France.
authors.forename: Erwan
authors.identifier: 0000-0002-8972-3971
authors.initials: E
authors.lastname: Le Gall
authors.affiliation: Électrochimie et Synthèse Organique, Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC , 2-8 rue Henri Dunant, F-94320 Thiais, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Léonel
authors.affiliation: Électrochimie et Synthèse Organique, Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC , 2-8 rue Henri Dunant, F-94320 Thiais, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Martens