title: Semitendinosus myopathy and treatment with adipose-derived stem cells in working German shepherd police dogs.
abstract: Semitendinosus myopathy has been treated with numerous surgical and non-surgical therapies resulting in recurrence of lameness within 2 to 9 months. Eleven cases of semitendinosus myopathy diagnosed in 8 working police dogs that were treated with adipose-derived mesenchymal stem cells were retrospectively evaluated. At short-term follow-up < 6 mo, ultrasound and gait evaluations revealed a mean reduction in the overall intramuscular lesion size of 54.82% (SD +/- 18.02; range: 30.5% to 82.7%) and reduction in the Visual Assessment Score (VAS) of 1 to 3 points. At long-term follow-up > 1 y, in 8 cases the dogs had a normal gait and in 3 cases the dogs had an improved gait compared with initial examination, and all 8 dogs returned to active police work. Fisher's exact test resulted inP= 0.000008 when comparing published historical reports and these 11 cases for resolution of lameness and return to active duty.
authors.affiliation: Pennsylvania Veterinary Specialty and Emergency Associates at Hickory Veterinary Hospital, 2303 Hickory Road, Plymouth Meeting, Pennsylvania 19403, USA (Gibson, N.O. Brown); Veterinary Orthopedic Surgery Service, 1618 Washington Blvd, Fremont, California 94539, USA (S.G. Brown).
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Gibson
authors.affiliation: Pennsylvania Veterinary Specialty and Emergency Associates at Hickory Veterinary Hospital, 2303 Hickory Road, Plymouth Meeting, Pennsylvania 19403, USA (Gibson, N.O. Brown); Veterinary Orthopedic Surgery Service, 1618 Washington Blvd, Fremont, California 94539, USA (S.G. Brown).
authors.forename: S Gary
authors.initials: SG
authors.lastname: Brown
authors.affiliation: Pennsylvania Veterinary Specialty and Emergency Associates at Hickory Veterinary Hospital, 2303 Hickory Road, Plymouth Meeting, Pennsylvania 19403, USA (Gibson, N.O. Brown); Veterinary Orthopedic Surgery Service, 1618 Washington Blvd, Fremont, California 94539, USA (S.G. Brown).
authors.forename: Nancy O
authors.initials: NO
authors.lastname: Brown
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D004283:Dog Diseases / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D004285:Dogs; D000070633:Hamstring Muscles / Q000473:pathology*; D007794:Lameness, Animal / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D009135:Muscular Diseases / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D012189:Retrospective Studies; D033581:Stem Cell Transplantation / Q000662:veterinary*; D016896:Treatment Outcome