title: Epidemiology of Invasive Haemophilus influenzae Disease, Europe, 2007-2014.
abstract: We describe the epidemiology of invasive Haemophilus influenzae disease during 2007-2014 in 12 European countries and assess overall H. influenzae disease trends by serotype and patient age. Mean annual notification rate was 0.6 cases/100,000 population, with an increasing annual trend of 3.3% (95% CI 2.3% to 4.3%). The notification rate was highest for patients <1 month of age (23.4 cases/100,000 population). Nontypeable H. influenzae (NTHi) caused 78% of all cases and showed increasing trends among persons <1 month and >20 years of age. Serotype f cases showed an increasing trend among persons >60 years of age. Serotype b cases showed decreasing trends among persons 1-5 months, 1-4 years, and >40 years of age. Sustained success of routine H. influenzae serotype b vaccination is evident. Surveillance systems must adopt a broad focus for invasive H. influenzae disease. Increasing reports of NTHi, particularly among neonates, highlight the potential benefit of a vaccine against NTHi.
authors.forename: Robert
authors.initials: R
authors.lastname: Whittaker
authors.forename: Assimoula
authors.initials: A
authors.lastname: Economopoulou
authors.forename: Joana Gomes
authors.initials: JG
authors.lastname: Dias
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Bancroft
authors.forename: Miriam
authors.initials: M
authors.lastname: Ramliden
authors.forename: Lucia Pastore
authors.initials: LP
authors.lastname: Celentano
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005060:Europe / Q000453:epidemiology; D006192:Haemophilus Infections / Q000453:epidemiology* / Q000382:microbiology*; D006193:Haemophilus influenzae / Q000145:classification / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D008875:Middle Aged; D012189:Retrospective Studies; D065288:Serogroup; D055815:Young Adult
keywords: Europe; bacteria; coccobacillus; epidemiology; invasive Haemophilus influenzae disease; invasive disease; invasive pathogen; serotype; surveillance; temporal trends; vaccine