title: Sequential Double "Clicks" toward Structurally Well-Defined HeterogeneousN-Glycoclusters: The Importance of Cluster Heterogeneity on Pattern Recognition In Vivo.
abstract: Structurally well-defined heterogeneousN-glycoclustersare prepared on albumin via a double click procedure. The number of glycan molecules present, in addition to the spatial arrangement of glycans in the heterogeneous glycoclusters, plays an important role in the in vivo kinetics and organ-selective accumulation through glycan pattern recognition mechanisms.
authors.affiliation: Biofunctional Synthetic Chemistry Laboratory RIKEN, Hirosawa Wako-shi, Saitama 351-0198 Japan; Biofunctional Chemistry Laboratory A. Butlerov Institute of Chemistry Kazan Federal University 18 Kremlyovskaya street Kazan 420008 Russia.
authors.forename: Liliya
authors.initials: L
authors.lastname: Latypova
authors.affiliation: Biofunctional Synthetic Chemistry Laboratory RIKEN, Hirosawa Wako-shi, Saitama 351-0198 Japan; Biofunctional Chemistry Laboratory A. Butlerov Institute of Chemistry Kazan Federal University 18 Kremlyovskaya street Kazan 420008 Russia.
authors.forename: Regina
authors.initials: R
authors.lastname: Sibgatullina
authors.affiliation: Biofunctional Synthetic Chemistry Laboratory RIKEN, Hirosawa Wako-shi, Saitama 351-0198 Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ogura
authors.affiliation: Biofunctional Synthetic Chemistry Laboratory RIKEN, Hirosawa Wako-shi, Saitama 351-0198 Japan.
authors.forename: Katsumasa
authors.initials: K
authors.lastname: Fujiki
authors.affiliation: Biofunctional Chemistry Laboratory A. Butlerov Institute of Chemistry Kazan Federal University 18 Kremlyovskaya street Kazan 420008 Russia.
authors.forename: Alsu
authors.initials: A
authors.lastname: Khabibrakhmanova
authors.affiliation: Center for Life Science Technologies RIKEN Minatojima-minamimachi, Chuo-ku Kobe, Hyogo 650-0047 Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tahara
authors.affiliation: Center for Life Science Technologies RIKEN Minatojima-minamimachi, Chuo-ku Kobe, Hyogo 650-0047 Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nozaki
authors.affiliation: Biofunctional Synthetic Chemistry Laboratory RIKEN, Hirosawa Wako-shi, Saitama 351-0198 Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Urano
authors.affiliation: Biofunctional Synthetic Chemistry Laboratory RIKEN, Hirosawa Wako-shi, Saitama 351-0198 Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Tsubokura
authors.affiliation: Center for Life Science Technologies RIKEN Minatojima-minamimachi, Chuo-ku Kobe, Hyogo 650-0047 Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Onoe
authors.affiliation: Center for Life Science Technologies RIKEN Minatojima-minamimachi, Chuo-ku Kobe, Hyogo 650-0047 Japan.
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Biofunctional Chemistry Laboratory A. Butlerov Institute of Chemistry Kazan Federal University 18 Kremlyovskaya street Kazan 420008 Russia.
authors.forename: Almira
authors.initials: A
authors.lastname: Kurbangalieva
authors.affiliation: Biofunctional Synthetic Chemistry Laboratory RIKEN, Hirosawa Wako-shi, Saitama 351-0198 Japan; Biofunctional Chemistry Laboratory A. Butlerov Institute of Chemistry Kazan Federal University 18 Kremlyovskaya street Kazan 420008 Russia; JST-PRESTO, Hirosawa Wako-shi, Saitama 351-0198 Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Tanaka
keywords: N‐glycoalbumin; biodistribution; heterogeneity; in vivo kinetics; noninvasive fluorescence imaging; pattern recognition