title: Myocardial homing of mesenchymal stem cells following intrapericardial application and amplification by inflammation - an experimental pilot study.
abstract: Recent studies demonstrated potential effects of stem cells on cardiac function in heart failure. However, influences of the technique of application remained undetermined. In the present study, the pericardial sac was used as depot for fluorescent-labeled mesenchymal stem cells in rats. To evaluate influences of inflammation on cell homing, a sterile pericarditis was induced by talc. It is shown that intrapericardial stem cell application is sufficient to provide myocardial penetration. The extent of homing was amplified by inflammation in a talc-induced pericarditis.
authors.affiliation: a Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University, Marburg, Germany.
authors.forename: Nina
authors.initials: N
authors.lastname: Jung
authors.affiliation: b Department of Medicine, Cardiology, Philipps University, Marburg, Germany.
authors.forename: Heinz
authors.initials: H
authors.lastname: Rupp
authors.affiliation: a Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University, Marburg, Germany.
authors.forename: A Rembert
authors.initials: AR
authors.lastname: Koczulla
authors.affiliation: a Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University, Marburg, Germany.
authors.forename: Claus F
authors.initials: CF
authors.lastname: Vogelmeier
authors.affiliation: a Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University, Marburg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Alter
mesh_terms: D000818:Animals; D002460:Cell Line; D007249:Inflammation / Q000473:pathology; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010496:Pericardium / Q000473:pathology*; D010865:Pilot Projects; D051381:Rats; D017208:Rats, Wistar
keywords: cellules souches; heart failure; inflammation; insuffisance cardiaque; myocardial homing; pericarditis; pericardium; péricarde; péricardite; stem cells; « homing » myocardique