title: A novel model to estimate lymph node metastasis in endometrial cancer patients.
abstract: To evaluate the postoperative pathological characteristics of hysterectomy specimens, preoperative cancer antigen (CA)-125 levels and imaging modalities in patients with endometrial cancer and to build a risk matrix model to identify and recruit patients for retroperitoneal lymphadenectomy.
  A total of 405 patients undergoing surgical treatment for endometrial cancer were retrospectively reviewed and analyzed. Clinical (age and body mass index), laboratory (CA-125), radiological (lymph node evaluation), and pathological (tumour size, grade, lymphovascular space invasion, lymph node metastasis, and myometrial invasion) parameters were used to test the ability to predict lymph node metastasis. Four parameters were selected by logistic regression to create a risk matrix for nodal metastasis.
  Of the 405 patients, 236 (58.3%) underwent complete pelvic and para-aortic lymphadenectomy, 96 (23.7%) underwent nodal sampling, and 73 (18%) had no surgical lymph node assessment. The parameters predicting nodal involvement obtained through logistic regression were myometrial infiltration >50%, lymphovascular space involvement, pelvic lymph node involvement by imaging, and a CA-125 value >21.5 U/mL. According to our risk matrix, the absence of these four parameters implied a risk of lymph node metastasis of 2.7%, whereas in the presence of all four parameters the risk was 82.3%.
  Patients without deep myometrial invasion and lymphovascular space involvement on the final pathological examination and with normal CA-125 values and lymph node radiological examinations have a relatively low risk of lymph node involvement. This risk assessment matrix may be able to refer patients with high-risk parameters necessitating lymphadenectomy and to decide the risks and benefits of lymphadenectomy.
authors.affiliation: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Instituto do Câncer do Estado de São Paulo - ICESP, Departamento de Ginecologia e Obstetrícia, São Paulo/SP, Brazil.
authors.forename: Cristina
authors.initials: C
authors.lastname: Anton
authors.affiliation: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Instituto do Câncer do Estado de São Paulo - ICESP, Departamento de Ginecologia e Obstetrícia, São Paulo/SP, Brazil.
authors.forename: Alexandre Silva
authors.initials: AS
authors.lastname: E Silva
authors.affiliation: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Instituto do Câncer do Estado de São Paulo - ICESP, Departamento de Ginecologia e Obstetrícia, São Paulo/SP, Brazil.
authors.forename: Edmund Chada
authors.initials: EC
authors.lastname: Baracat
authors.affiliation: Asklepios Hospital Hamburg, Department of Advanced Operative and Oncologic Gynecology, Germany.|Akdeniz University, Department of Obstetrics and Gynecology, Antalya, Turkey.
authors.forename: Nasuh Utku
authors.initials: NU
authors.lastname: Dogan
authors.affiliation: Asklepios Hospital Hamburg, Department of Advanced Operative and Oncologic Gynecology, Germany.
authors.forename: Christhardt
authors.initials: C
authors.lastname: Köhler
authors.affiliation: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Instituto do Câncer do Estado de São Paulo - ICESP, Departamento de Ginecologia e Obstetrícia, São Paulo/SP, Brazil.
authors.forename: Jesus Paula
authors.initials: JP
authors.lastname: Carvalho
authors.affiliation: Asklepios Hospital Hamburg, Department of Advanced Operative and Oncologic Gynecology, Germany.
authors.forename: Giovanni Mastrantonio
authors.initials: GM
authors.lastname: di Favero
mesh_terms: D000328:Adult; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood*; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000175:diagnosis* / Q000517:prevention & control; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D018394:CA-125 Antigen