title: [Research progress of peripheral blood count test in the evaluation of prognosis of gastric cancer].
abstract: Gastric cancer (GC) is one of the most common tumor in the world, and remains a major public health problem and one of the leading causes of death. Recently many researches have demonstrated that systemic inflammatory response is associated with prognosis and response to therapy in gastric cancer, and the peripheral blood count test can partly reflect the systemic inflammatory response. Based on the peripheral blood count test, there are a lot of research regarding the relation between the platelet count (PLT), neutrophil, lymphocyte, white blood cell (WBC), neutrophil to lymphocyte ratio(NLR), platelet to lymphocyte ratio (PLR) with their prognostic role in gastric cancer. A high PLT and preoperative lymphocytopenia are both associated with increased lymph node metastasis, stage (III(+IIII(), serosal invasion (T3+T4) risk and poorer overall survival. Besides above, platelet monitoring following surgery can be applied to predict the recurrence for patients with GC that suffer preoperative high PLT but have restored PLT levels following resection. Moreover systemic inflammatory factors based on blood parameters, such as PLR, NLR and so on, have relation with the poor prognosis of patients with GC. Among them, high NLR is a negative predictor of prognosis in GC patients. However PLR remains inconsistent, while most researches demonstrated high PLR may be useful prognostic factor rather than independent prognostic factor. There are still some limitations which include various cut-off values, little of clinician attention, the uncertain mechanism, etc. Here we review the research progress in the prognostic role of the blood count test in gastric cancer.
authors.forename: Zhengshui
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Gastrointestinal Surgery, The Second Affiliated hospital to Nanchang University, Nanchang 330006, China. chenghuadoctor@163.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Cheng
mesh_terms: D001772:Blood Cell Count / Q000379:methods* / Q000706:statistics & numerical data; D001792:Blood Platelets / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D007958:Leukocyte Count / Q000706:statistics & numerical data; D008207:Lymphatic Metastasis / Q000175:diagnosis* / Q000276:immunology; D018655:Lymphocyte Count / Q000706:statistics & numerical data; D008231:Lymphopenia / Q000097:blood / Q000503:physiopathology; D009361:Neoplasm Invasiveness / Q000276:immunology; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000175:diagnosis*; D009367:Neoplasm Staging / Q000706:statistics & numerical data; D009504:Neutrophils / Q000276:immunology; D010976:Platelet Count / Q000706:statistics & numerical data; D011379:Prognosis; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology / Q000401:mortality*; D016896:Treatment Outcome