title: Endovascular treatment of intracranial aneurysms with the p64 flow diverter stent: mid-term results in 35 patients with 41 intracranial aneurysms.
abstract: BACKGROUND
  The p64 flow diverter (FD) device is a fully resheathable and detachable stent dedicated for endovascular treatment (EVT) of intracranial aneurysms (IAs). We report our mid-term experience with this device.
  
  
  METHODS
  Between January 2015 and February 2016, we retrospectively identified, in our prospectively maintained database, all patients treated with p64 FDs in two institutions. Independent clinical follow-up was performed by a vascular neurologist. Imaging follow-up included a digitalized subtraction angiography (DSA) at 3, 6, and 12 months and a magnetic resonance angiography (MRA) at 12 months.
  
  
  RESULTS
  Thirty-nine patients (22 women/17 men; median age 54 years) with 48 IAs (median aneurysm size 6.2 mm; mean neck size 3.4 mm) were identified. All IAs were saccular and unruptured. Failure of safe stent delivery occurred in 15% of cases (7/48 IAs) which were excluded. Transient neurological morbidity occurred in 2/35 patients (5.7%) including one delayed thromboembolic complication. No permanent morbidity or mortality was encountered. Complete aneurysmal occlusion at 3, 6, and 12 months was 20/30 (66.6%), 18/27 (66.6%), and 24/28 (85.7%), respectively. Intra-stent stenosis was observed in 9/29 patients (31%) and classified as moderate in 4/29 (13.7%) and mild in 5/29 patients (17.2%). These stenoses gradually improved over time, with only mild stenoses being identified at 6 months and at 12 months.
  
  
  CONCLUSIONS
  In our small case series, the p64 FD stent appears safe and effective for EVT of IAs. A high occlusion rate and a low morbidity rate were observed.
authors.affiliation: Cliniques Universitaires de Bruxelles, Erasme University Hospital, Imagerie médicale - Clinique de Neuroradiologie, Route de Lennik 808 - B, Bruxelles, Belgium. ricardofelixmorais@gmail.com.|Medical Imaging Department, Coimbra University and Hospital Centre, Coimbra, Portugal. ricardofelixmorais@gmail.com.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Morais
authors.affiliation: Cliniques Universitaires de Bruxelles, Erasme University Hospital, Imagerie médicale - Clinique de Neuroradiologie, Route de Lennik 808 - B, Bruxelles, Belgium.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Mine
authors.affiliation: Cliniques Universitaires de Bruxelles, Erasme University Hospital, Imagerie médicale - Clinique de Neuroradiologie, Route de Lennik 808 - B, Bruxelles, Belgium.|Department of Radiology, Centre Hospitalier Régional Citadelle, Radiology, Liège, Belgium.
authors.forename: Pierre Julien
authors.initials: PJ
authors.lastname: Bruyère
authors.affiliation: Department of Neurology, Erasme University Hospital, Brussels, Belgium.
authors.forename: Gilles
authors.initials: G
authors.lastname: Naeije
authors.affiliation: Cliniques Universitaires de Bruxelles, Erasme University Hospital, Imagerie médicale - Clinique de Neuroradiologie, Route de Lennik 808 - B, Bruxelles, Belgium.
authors.forename: Boris
authors.initials: B
authors.lastname: Lubicz
mesh_terms: D015901:Angiography, Digital Subtraction; D002533:Cerebral Angiography; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015607:Stents; D016896:Treatment Outcome
keywords: Flow diverter; Intracranial aneurysm; Neuroradiology; p64