title: Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns.
abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder that affects as many as 400 million people worldwide, making it the most common enzymatic defect. Subjects with G6PD deficiency are more likely to develop neonatal hyperbilirubinemia potentially leading to kernicterus and are at increased risk for acute hemolytic anemia when exposed to pro-oxidant compounds such as anti-malarial drugs. We collected umbilical cord blood from 300 males born in Uganda to assess for novel markers of systemic oxidative stress. We determined that 10.7% of the samples collected were G6PD A- deficient (G202A/A376G) and when these were compared with unaffected controls, there was significantly higher 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentration, elevated ferritin, increased leukocyte count and higher small molecule antioxidant capacity. These data suggest increased baseline oxidative stress and an elevated antioxidant response in umbilical cord blood of patients with G6PD deficiency.
authors.affiliation: Mayo Clinic School of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Stadem
authors.affiliation: Division of Global Health, Department of Pediatrics, University of Minnesota University, Minneapolis, Minnesota, United States of America.
authors.forename: Megan V
authors.initials: MV
authors.lastname: Hilgers
authors.affiliation: Department of Hematology, Mulago Hospital, Kampala, Uganda.
authors.forename: Derrick
authors.initials: D
authors.lastname: Bengo
authors.affiliation: Division of Global Health, Department of Pediatrics, University of Minnesota University, Minneapolis, Minnesota, United States of America.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Cusick
authors.affiliation: Department of Hematology, Mulago Hospital, Kampala, Uganda.
authors.forename: Susan
authors.initials: S
authors.lastname: Ndidde
authors.affiliation: Division of Global Health, Department of Pediatrics, University of Minnesota University, Minneapolis, Minnesota, United States of America.
authors.forename: Tina M
authors.initials: TM
authors.lastname: Slusher
authors.affiliation: Division of Global Health, Department of Pediatrics, University of Minnesota University, Minneapolis, Minnesota, United States of America.
authors.forename: Troy C
authors.identifier: http://orcid.org/0000-0001-9174-8919
authors.initials: TC
authors.lastname: Lund
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005312:Fetal Blood / Q000378:metabolism*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018384:Oxidative Stress; D014454:Uganda
chemical_list: D015415:Biomarkers