title: Leukocyte telomere length in Hispanic schizophrenia patients under treatment with olanzapine.
abstract: Different lines of evidence indicate that patients with schizophrenia (SZ) exhibit accelerated aging. Leukocyte telomere length (TL), an aging marker, is associated with age-related and chronic pathologies, including schizophrenia. We analyzed leukocyte TL in 170 SZ patients of Hispanic ancestry grouped based on antipsychotic treatment, compared to 126 matched controls. The group under treatment with atypical antipsychotics was further subdivided according to the risk of medication to cause metabolic syndrome (MetS). Our results show significant erosion in the TL of SZ patients under treatment with the atypical antipsychotics clozapine and olanzapine, which cause high-risk for MetS, compared to healthy controls and patients under treatment with medium and low-risk antipsychotics. However, when the analysis was done separately for clozapine and olanzapine, a significant difference remained only for olanzapine. These findings suggest that atypical antipsychotics that cause high-risk for MetS, particularly olanzapine, may modulate leukocyte TL in SZ patients. Future research is required to elucidate if in fact atypical antipsychotics are involved in TL maintenance in SZ subjects and the mechanism by which this occurs.
authors.affiliation: Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Department of Genetics, National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez. Insurgentes Sur 3877 Col. La Fama, Tlalpan, C. P. 14269 Mexico city, Mexico. Electronic address: Nancy.MonroyJaramillo@uth.tmc.edu.
authors.forename: Nancy
authors.initials: N
authors.lastname: Monroy-Jaramillo
authors.affiliation: Department of Neuropsychology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez. Insurgentes Sur 3877 Col. La Fama, Tlalpan, C. P. 14269 Mexico city, Mexico. Electronic address: yaneth_r@hotnail.com.
authors.forename: Yaneth
authors.initials: Y
authors.lastname: Rodríguez-Agudelo
authors.affiliation: Department of Psychiatry, National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez. Insurgentes Sur 3877 Col. La Fama, Tlalpan, C. P. 14269 Mexico city, Mexico. Electronic address: karloz2@hotmail.com.
authors.forename: Luis Carlos
authors.initials: LC
authors.lastname: Aviña-Cervantes
authors.affiliation: Department of Psychiatry, Division of Schizophrenia and Related Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Electronic address: robertsd5@uthscsa.edu.
authors.forename: David L
authors.initials: DL
authors.lastname: Roberts
authors.affiliation: Department of Psychiatry, Division of Schizophrenia and Related Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Electronic address: velligand@uthscsa.edu.
authors.forename: Dawn I
authors.initials: DI
authors.lastname: Velligan
authors.affiliation: Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA. Electronic address: Consuelo.WalssBass@uth.tmc.edu.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Walss-Bass
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007962:Leukocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010045:Outpatients; D012559:Schizophrenia / Q000188:drug therapy* / Q000208:ethnology / Q000235:genetics*; D016615:Telomere / Q000187:drug effects* / Q000235:genetics; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine
keywords: Atypical antipsychotics; Metabolic syndrome; Olanzapine; Schizophrenia; Telomere length