title: New phenylpropanoid and 6H-dibenzo[b,d]pyran-6-one derivatives from the stems of Dasymaschalon rostratum.
abstract: Three new phenylpropanoid derivatives, dasymaroacid A (1), dasymaroesters B and C (2 and 3), and one new polyoxygenated 6H-dibenzo[b,d]pyran-6-one derivative dasymarolactone D (4), together with seven known compounds (5-11), were isolated from the stems of Dasymaschalon rostratum Merr. Compounds 1 and 2 are unusual phenylpropanoid derivatives with a polymethyl substituted cyclopentene conjugated diketone as a substituent, and 3 is a unique cinnamic acid detective with a polymethyl substituted cyclohexene conjugated triketone as a substituent. Their structures were elucidated by extensive spectroscopic methods and chemical method, and 4 was further confirmed by the single crystal X-ray diffraction method. Compounds 1-4 and 7 showed weak anti-HIV-1 activities with EC50values ranged from 16.44 to 25.91μM.
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
authors.forename: Zhang-Xin
authors.initials: ZX
authors.lastname: Yu
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Niu
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
authors.forename: Xiao-Bao
authors.initials: XB
authors.lastname: Li
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
authors.forename: Cai-Juan
authors.initials: CJ
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
authors.forename: Xin-Ming
authors.initials: XM
authors.lastname: Song
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Chen
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Electronic address: sxp628@126.com.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Song
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China; Hainan Institute of Science and Technology, Haikou 571126, PR China. Electronic address: hchr116@126.com.
authors.forename: Chang-Ri
authors.initials: CR
authors.lastname: Han
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
authors.forename: Shu-Xian
authors.initials: SX
authors.lastname: Wu
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification; D015497:HIV-1 / Q000187:drug effects*; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D007783:Lactones; D010616:Phenanthrenes; C073118:6H-dibenzo-(b,d)-pyran-6-one
keywords: 6H-dibenzo[b,d]pyran-6-one; Anti-HIV-1 activity; Dasymaschalon rostratum; Phenylpropanoid