title: Nephroprotective effect of Rudgea viburnoides (Cham.) Benth leaves on gentamicin-induced nephrotoxicity in rats.
abstract: CONCLUSIONS
  Rudgea viburnoides, popularly known as "congonha-de-bugre" or "erva de bugre", is used in folk medicine as hypotensive, blood depurative, anti-rheumatic, diuretic and in the treatment of kidney and bladder pain.
  
  
  OBJECTIVE
  Based on the popularly acclaimed nephron-protective effect of R. viburnoides, we investigated, using rats, the protective effect of this plant extract on gentamicin-induced kidney injury.
  
  
  METHODS
  Urinary volume, water and food intakes were assessed in adult male Wistar rats (naive or gentamicin-induced model of nephrotoxicity) treated with R. viburnoides extract. Also blood and kidney samples were collected for further laboratory and histological analyses.
  
  
  RESULTS
  R. viburnoides leaves extract improved renal function. It also improved the renal function impairments caused by gentamicin-induced nephrotoxicity, as revealed by glomerular filtration rate, urine output and proteinuria.
  
  
  CONCLUSIONS
  R. viburnoides exert renoprotective effect, which may support its popular use for renal diseases treatment.
authors.affiliation: Laboratório de Farmacologia de Produtos Naturais, ICB, UFG, Goiânia, GO, Brazil.
authors.forename: Pablinny
authors.initials: P
authors.lastname: Moreira Galdino
authors.affiliation: Laboratório de Fisiologia e Terapêutica Cardiovascular, ICB, UFG, Goiânia, GO, Brazil.
authors.forename: Layse
authors.initials: L
authors.lastname: Nunes Alexandre
authors.affiliation: Escola Superior de Educação Física e Fisioterapia/UEG, Goiânia, GO, Brazil.
authors.forename: Lílian
authors.initials: L
authors.lastname: Fernanda Pacheco
authors.affiliation: Instituto de Patologia Tropical e Saúde Pública/ UFG, Goiânia, GO, Brazil.
authors.forename: Ruy
authors.initials: R
authors.lastname: de Souza Lino Junior
authors.affiliation: Laboratório de Pesquisa em Produtos Naturais, FF, UFG, Goiânia, GO, Brazil.
authors.forename: José Realino
authors.initials: JR
authors.lastname: de Paula
authors.affiliation: Centro de Pesquisas em Neurociência e Fisiologia Cardiovascular, ICB, UFG, Goiânia, GO, Brazil.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Rodrigues Pedrino
authors.affiliation: Laboratório de Fisiologia e Terapêutica Cardiovascular, ICB, UFG, Goiânia, GO, Brazil.
authors.forename: Carlos
authors.initials: C
authors.lastname: Henrique Xavier
authors.affiliation: Laboratório de Fisiologia e Terapêutica Cardiovascular, ICB, UFG, Goiânia, GO, Brazil. Electronic address: patferri@hotmail.com.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Maria Ferreira
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D000900:Anti-Bacterial Agents; D003404:Creatinine / Q000097:blood; D005839:Gentamicins; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D011188:Potassium / Q000097:blood; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D019666:Rubiaceae; D012964:Sodium / Q000097:blood
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010936:Plant Extracts; D020011:Protective Agents; D012964:Sodium; D003404:Creatinine; D011188:Potassium
keywords: Gentamicin; Medicinal plants; Nephrotoxicity; Rudgea viburnoides