title: Effect of Successive Administration of Vancomycin and Amikacin on Auditory Function of Immature Animals.
abstract: Effect of successive administration vancomycin and amikacin in therapeutic doses on immature auditory organ was compared to single administration of the same drugs in chronic experiments on immature rabbits by recording of short-latency auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). Drug administration always increased significantly the ABR peak I threshold. Ototoxic antibiotics did not change DPOAE, but selectively affected activity of outer hair cells. No enhancement of the ototoxic effects was observed after successive administration of the two antibiotics.
authors.affiliation: N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: D'yakonova
authors.affiliation: N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Kamkina
authors.affiliation: N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Rakhmanova
authors.affiliation: N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russia.
authors.forename: Yu S
authors.initials: YS
authors.lastname: Ishanova
authors.affiliation: N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russia. 5342748@mail.ru.
authors.forename: D S
authors.initials: DS
authors.lastname: Burmistrova
mesh_terms: D000583:Amikacin / Q000009:adverse effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects* / Q000502:physiology; D018072:Hair Cells, Auditory, Outer / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D013997:Time Factors; D014640:Vancomycin / Q000009:adverse effects*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D000583:Amikacin
keywords: amikacin; immature auditory analyzer; rabbits; short-latency auditory brainstem response; vancomycin