title: Physical Activity: A Viable Way to Reduce the Risks of Mild Cognitive Impairment, Alzheimer's Disease, and Vascular Dementia in Older Adults.
abstract: A recent alarming rise of neurodegenerative diseases in the developed world is one of the major medical issues affecting older adults. In this review, we provide information about the associations of physical activity (PA) with major age-related neurodegenerative diseases and syndromes, including Alzheimer's disease, vascular dementia, and mild cognitive impairment. We also provide evidence of PA's role in reducing the risks of these diseases and helping to improve cognitive outcomes in older adults. Finally, we describe some potential mechanisms by which this protective effect occurs, providing guidelines for future research.
authors.affiliation: Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721-0038, USA. gallaway@email.arizona.edu.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Gallaway
authors.affiliation: Nishinomiya Kyoritsu Neurosurgical Hospital, Hyogo 663-8211, Japan. miyake@nk-hospital.or.jp.
authors.forename: Hiroji
authors.initials: H
authors.lastname: Miyake
authors.affiliation: Department of Medicine, Vanderbilt University, Nashville, TN 37232-5280, USA. maciej.buchowski@vanderbilt.edu.
authors.forename: Maciej S
authors.initials: MS
authors.lastname: Buchowski
authors.affiliation: Chiba Prefectural University of Health Sciences, Chiba 261-0014, Japan. mieko.shimada@cpuhs.ac.jp.
authors.forename: Mieko
authors.initials: M
authors.lastname: Shimada
authors.affiliation: National Institute of Fitness & Sport in Kanoya, Kagoshima 891-2311, Japan. yositake@nifs-k.ac.jp.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshitake
authors.affiliation: Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721-0038, USA. ask1@email.arizona.edu.
authors.forename: Angela S
authors.initials: AS
authors.lastname: Kim
authors.affiliation: Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721-0038, USA. hongu@email.arizona.edu.
authors.forename: Nobuko
authors.initials: N
authors.lastname: Hongu
keywords: Alzheimer’s disease; aging; cognitive decline; dementia; health; mild cognitive impairment; physical activity