title: Therapeutic effect ofLinum usitatissimumL. in STZ-nicotinamide induced diabetic nephropathy via inhibition of AGE's and oxidative stress.
abstract: The present study was aimed to evaluate the potential of petroleum ether and hydro-alcoholic extract ofLinum usitatissimum(FPE and FHE) in STZ-nicotinamide induced diabetic nephropathy. GC-MS analysis of FPE revealed the presence of different fatty acids, heterocyclic compounds etc. Moreover, chromatography of FHE isolated Secoisolariciresinol diglycoside. After 30 days of STZ-administration, 100, 200 and 400 mg/kg of FPE and FHE were administered for 45 days. FPE and FHE produced significant attenuation in the glycemic status, renal parameter, lipid profile and level of antioxidant enzymes proving efficacy in diabetic nephropathy. Moreover, FPE and FHE produced significant reduction in the formation of AGEs in kidney. The results indicated that via amelioration oxidative stress and formation of AGEs, FPE and FHE produced significant nephroprotective effect in STZ- induced diabetic nephropathy in rats.
authors.affiliation: M.M. College of Pharmacy, M.M. University, Mullana-Ambala, Haryana 133207 India.
authors.forename: Navpreet
authors.initials: N
authors.lastname: Kaur
authors.affiliation: M.M. College of Pharmacy, M.M. University, Mullana-Ambala, Haryana 133207 India.
authors.forename: Lalit
authors.initials: L
authors.lastname: Kishore
authors.affiliation: M.M. College of Pharmacy, M.M. University, Mullana-Ambala, Haryana 133207 India.
authors.forename: Randhir
authors.initials: R
authors.lastname: Singh
keywords: Advanced glycation end products; Hyperglycemia; Oxidative stress; Secoisolariciresinol diglycoside