title: Fibromyalgia prevalence and associated factors in primary Sjögren's syndrome patients in a large cohort from the Spanish Society of Rheumatology registry (SJOGRENSER).
abstract: OBJECTIVE
  To assess fibromyalgia (FM) prevalence in a large cohort of primary Sjögren's syndrome patients (pSS) from a National Database.
  
  
  METHODS
  Data included in the national retrospective register of pSS patients of the Spanish Society of Rheumatology (SJOGRENSER) were analysed.
  
  
  RESULTS
  437 pSS patients were included and a 14.6% of FM prevalence was found. FM-pSS patients significantly showed more constitutional, fatigue and arthralgia symptoms, splenomegaly, genital, skin and ear involvement and dyslipidaemia (p<0.05), as well as higher ESSPRI and SSDAI scores (p<0.01). Several symptomatic treatments were more frequently used in FM-pSS patients. No differences were observed in laboratory markers, imaging techniques or histologic inflammatory findings. Patients with FM showed statistically more fatigue than pSS without FM. In the multivariate logistic regression analysis several features were associated to pSS-FM patients.
  
  
  CONCLUSIONS
  We show data on a reliable prevalence of FM in pSS patients and its multiple associated factors along with the presence of higher disease activity scores than patients who did not show FM. The presence of fatigue, arthralgia, constitutional symptoms and dyslipidaemia were more likely to coexist in pSS-FM patients.
authors.affiliation: Rheumatology Department, Hospital General Hospitalet-Moisès Broggi, Barcelona, Spain. vtorrente@hsjdbcn.org.
authors.forename: Vicenç
authors.initials: V
authors.lastname: Torrente-Segarra
authors.affiliation: Rheumatology Department, Hospital General Hospitalet-Moisès Broggi, Barcelona, Spain.
authors.forename: Hèctor
authors.initials: H
authors.lastname: Corominas
authors.affiliation: Research Unit, Spanish Society of Rheumatology, Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Sánchez-Piedra
authors.affiliation: Rheumatology Department, Hospital Infanta Sofía, San Sebastián de los Reyes, Madrid,Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: Fernández-Castro
authors.affiliation: Rheumatology Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Andreu
authors.affiliation: Rheumatology Department, Hospital Marqués de Valdecilla, Santander, Spain.
authors.forename: Víctor Manuel
authors.initials: VM
authors.lastname: Martínez-Taboada
authors.affiliation: Rheumatology Department, Hospital Germans Trias i Pujol, Badalona, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Olivé
authors.affiliation: Rheumatology Department, Hospital Marina Baixa, Alicante, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Rosas
authors.affiliation: Research Unit, Spanish Society of Rheumatology, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Sánchez-Alonso
mesh_terms: D000328:Adult; D000368:Aged; D018771:Arthralgia / Q000453:epidemiology / Q000209:etiology; D050171:Dyslipidemias / Q000453:epidemiology / Q000209:etiology; D005221:Fatigue / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005356:Fibromyalgia / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D012042:Registries; D012189:Retrospective Studies; D012219:Rheumatology; D012307:Risk Factors; D012859:Sjogren's Syndrome / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D012871:Skin Diseases / Q000453:epidemiology / Q000209:etiology; D012955:Societies, Medical; D013030:Spain / Q000453:epidemiology; D013163:Splenomegaly / Q000453:epidemiology / Q000209:etiology