title: Immune Complex Membranoproliferative Glomerulonephritis Associated with Transjugular Intrahepatic Portosystemic Shunts in Alcoholic Cirrhosis: Two Case Reports.
abstract: OBJECTIVE
  To report on 2 patients with alcoholic cirrhosis who were treated with transjugular intrahepatic portosystemic shunt (TIPS) placement.
  
  
  METHODS
  The 2 patients had a history of alcoholic cirrhosis, and TIPS surgery was performed on them. In both cases, 4 months after TIPS placement, proteinuria was observed along with histological alterations characteristic of immune complex membranoproliferative glomerulonephritis (MPGN).
  
  
  CONCLUSIONS
  The TIPS in one patient was successful without immediate complications, while the other patient was referred for a combined liver-kidney transplant. In both cases, immune complex MPGN might have developed after TIPS placement probably due to a reduced immune complex clearance.
authors.affiliation: Servicio de Nefrología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
authors.forename: Julio
authors.initials: J
authors.lastname: Hernández-Jaras
authors.forename: Jordi
authors.initials: J
authors.lastname: Espí-Reig
authors.forename: Rafael
authors.initials: R
authors.lastname: Alis
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: García-Martínez
authors.forename: Diego
authors.initials: D
authors.lastname: Rodríguez-Ortega
authors.forename: Lourdes
authors.initials: L
authors.lastname: Roca-Argente
authors.forename: Jose-Luis
authors.initials: JL
authors.lastname: Moll-Guillen
mesh_terms: D000936:Antigen-Antibody Complex / Q000276:immunology; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology* / Q000276:immunology; D008104:Liver Cirrhosis, Alcoholic / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000009:adverse effects*
chemical_list: D000936:Antigen-Antibody Complex
keywords: Hepatic cirrhosis; Membranoproliferative glomerulonephritis; Membranous glomerulonephritis; Portosystemic shunt; Transjugular intrahepatic portosystemic shunt