title: Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation.
abstract: Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.
authors.affiliation: College of Health Science & Nursing, Wuhan Polytechnic University, Wuhan, Hubei, China; Cardiovascular Research Institute, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Chang
authors.identifier: 0000-0002-7922-2823
authors.initials: C
authors.lastname: Xia
authors.affiliation: Cardiovascular Research Institute, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Rao
authors.affiliation: Cardiovascular Research Institute, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Jixin
authors.identifier: 0000-0002-3534-7480
authors.initials: J
authors.lastname: Zhong
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007333:Insulin Resistance / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*