title: Ventricular arrhythmias and sudden death in tetralogy of Fallot.
abstract: Malignant ventricular arrhythmias and sudden cardiac death may late happen in repaired tetralogy of Fallot, although probably less frequently than previously thought, especially with the advent of new surgical techniques/management. Ventricular tachycardias are caused by reentry around the surgical scars/patches and valves. Many predictive factors have been proposed, which suffer from poor accuracy. There is currently no recommended indication for prophylactic implantable cardioverter defibrillator implantation-except maybe in the case of multiple risk factors-while radiofrequncy ablation may be proposed in secondary prevention with or even without a back-up implantable cardioverter defibrillator in selected cases. Repeated cardiological investigations and monitoring should be proposed for every operated patient.
authors.affiliation: University Hospital Rangueil, 31059 Toulouse cedex 09, France; Unité Inserm U1048, Toulouse, France. Electronic address: mauryjphil@hotmail.com.
authors.forename: Philippe
authors.initials: P
authors.lastname: Maury
authors.affiliation: Inserm 1045, LIRYC Institute, Bordeaux University Hospital, Bordeaux, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Sacher
authors.affiliation: University Hospital Rangueil, 31059 Toulouse cedex 09, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Rollin
authors.affiliation: University Hospital Rangueil, 31059 Toulouse cedex 09, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Mondoly
authors.affiliation: University Hospital Rangueil, 31059 Toulouse cedex 09, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Duparc
authors.affiliation: Department of Cardiology, C5-P, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: Katja
authors.initials: K
authors.lastname: Zeppenfeld
authors.affiliation: University Children Hospital, Toulouse, France; Marie-Lannelongue Hospital, Department of Congenital Heart Diseases, Le Plessis-Robinson, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Hascoet
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D017115:Catheter Ablation; D016757:Death, Sudden, Cardiac / Q000209:etiology* / Q000517:prevention & control; D017147:Defibrillators, Implantable; D004554:Electric Countershock / Q000295:instrumentation; D006801:Humans; D011314:Preventive Health Services; D018570:Risk Assessment; D012307:Risk Factors; D017180:Tachycardia, Ventricular / Q000209:etiology / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy; D013771:Tetralogy of Fallot / Q000150:complications / Q000401:mortality*; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents
keywords: Ablation; Arythmies ventriculaires; Cardiopathie congénitale de l’adulte; GUCH; Mort subite; Sudden death; Tetralogy of Fallot; Tétralogie de Fallot; Ventricular tachycardia