title: Fragile phagocytes: FMRP positively regulates engulfment activity.
abstract: Defective immune system function is implicated in autism spectrum disorders, including Fragile X syndrome. In this issue, O'Connor et al. (2017.J. Cell Biol.https://doi.org/10.1083/jcb.201607093) demonstrate that phagocytic activity of systemic immune cells is compromised in aDrosophila melanogastermodel of Fragile X, highlighting intriguing new mechanistic connections between FMRP, innate immunity, and abnormal development.
authors.affiliation: Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health and Science University, Portland, OR 97239 loganm@ohsu.edu.
authors.forename: Mary A
authors.identifier: 0000-0001-6577-4574
authors.initials: MA
authors.lastname: Logan
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000276:immunology / Q000378:metabolism; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000378:metabolism*; D005600:Fragile X Syndrome / Q000276:immunology* / Q000378:metabolism*; D007113:Immunity, Innate / Q000276:immunology*; D010586:Phagocytes / Q000276:immunology* / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D051860:Fragile X Messenger Ribonucleoprotein 1