title: Prevalence of cardiovascular risk factors in people with epilepsy.
abstract: Epilepsy has been associated with cardiovascular comorbidity. This study aimed to assess the potential association between cardiovascular risk factors (CRFs), antiepileptic drugs (AEDs), and etiology.
  
  
  
  A single-center retrospective epilepsy cohort from the decade of 2004-2013 was assessed. Poisson regression models with robust variance were estimated to obtain CRF prevalence ratios (PR) according to AED prescription and etiology.
  
  
  
  After excluding patients in the monotherapy group with vascular etiology or previous cardiovascular events, in the remaining 400 patients, enzyme-inducer AEDs (EIAEDs), especially phenytoin (PHT), were associated with higher prevalence of dyslipidemia (PRa 1.77,p< .05), compared to valproic acid. No etiology was associated with higher prevalence of any CRF.
  
  
  
  Patients treated with EIAEDs, especially PHT, had higher prevalence of dyslipidemia.
authors.affiliation: Neurovascular Research Group Fundació Institut Mar d'Investigacions Mèdiques (FIMIM) Barcelona Spain; Universitat Autònoma de Barcelona (UAB) Barcelona Spain.
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Vivanco-Hidalgo
authors.affiliation: Neurology Department Parc de Salut Mar Barcelona Spain.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Gomez
authors.affiliation: Neurology Department Parc de Salut Mar Barcelona Spain.
authors.forename: Antia
authors.initials: A
authors.lastname: Moreira
authors.affiliation: Neurology Department Parc de Salut Mar Barcelona Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Díez
authors.affiliation: Cardiovascular Epidemiology and Genetics Research Group Fundació Institut Mar d'Investigacions Mèdiques (FIMIM) Barcelona Spain.
authors.forename: Roberto
authors.initials: R
authors.lastname: Elosua
authors.affiliation: Neurovascular Research Group Fundació Institut Mar d'Investigacions Mèdiques (FIMIM) Barcelona Spain; Universitat Autònoma de Barcelona (UAB) Barcelona Spain; Neurology Department Parc de Salut Mar Barcelona Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Roquer
mesh_terms: D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000453:epidemiology*; D015897:Comorbidity; D050171:Dyslipidemias / Q000139:chemically induced / Q000453:epidemiology*; D004827:Epilepsy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects*; D015995:Prevalence; D012042:Registries / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin
keywords: antiepileptic drugs; cardiovascular risk factors; comorbidity; epilepsy