title: DNA methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells.
abstract: Previous studies revealed that some bioactive food components have anti-cancer effects. However epigenetic effects of dietary compound resveratrol are largely unknown in breast cancer cells (M.A. Dawson, T. Kouzarides, 2012) [1]. Here we provide novel data and comparisons of DNA methylation status of promoter gene regions in response to resveratrol treatment at 24 h and 48 h versus untreated MDA-MB-231 breast cancer cells. DNA methylation changes were measured using Array-PRIMES method (aPRIMES) followed by whole-genome hybridization using human DNA methylation promoter microarray NimbleGen HG18 Refseq Promoter 3×720 K array. Our data were associated to corresponding changes in mRNA expression in a set of cancer-related genes. Using gene ontology analysis we also identify cancer-related cellular processes and pathways that can be epigenetically reprogramed by resveratrol. Data in this article are associated to the research articles "Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol". Medina Aguilar et al., PLoS ONE 11(6): e0157866. doi:10.1371/journal.pone.0157866 2016 (A.R. Medina, P.C. Pérez, L.A. Marchat, P. Gariglio, M.J. García, C.S. Rodríguez, G.E. Ruíz, et al., 2016) [2]; and "Resveratrol inhibits cell cycle progression by targeting Aurora kinase A and Polo-like kinase 1 in breast cancer cells" in Oncology Reports. Medina Aguilar et al., 2016 Jun; 35(6):3696-704. doi: 10.3892/or.2016.4728 (A.R. Medina, P. Gariglio, M.J. García, O.E. Arechaga, S.N. Villegas, C.M. Martínez et al., 2016) [3].
authors.affiliation: Departmento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), México City, México.
authors.forename: Rubiceli
authors.initials: R
authors.lastname: Medina-Aguilar
authors.affiliation: Unidad de Biomedicina, FES-Iztacala UNAM, Tlalnepantla, Estado de México, México.
authors.forename: Carlos
authors.initials: C
authors.lastname: Pérez-Plasencia
authors.affiliation: Departmento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), México City, México.
authors.forename: Patricio
authors.initials: P
authors.lastname: Gariglio
authors.affiliation: Escuela Nacional de Medicina y Homeopatía. Red de Biotecnología. Instituto Politécnico Nacional, México City, México.
authors.forename: Laurence A
authors.initials: LA
authors.lastname: Marchat
authors.affiliation: Laboratorio de Oncogenómica y Proteómica del Cáncer, Universidad Autónoma de la Ciudad de México, México City, México.
authors.forename: Ali
authors.initials: A
authors.lastname: Flores-Pérez
authors.affiliation: Laboratorio de Oncogenómica y Proteómica del Cáncer, Universidad Autónoma de la Ciudad de México, México City, México.
authors.forename: César
authors.initials: C
authors.lastname: López-Camarillo
authors.affiliation: Departmento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), México City, México.
authors.forename: Jaime
authors.initials: J
authors.lastname: García Mena
keywords: Breast cancer; DNA methylation; Genome-wide methylome; Oncogenes; Resveratrol; Tumor suppressor genes