title: MRI-guided and ultrasound-triggered release of NO by advanced nanomedicine.
abstract: Nitric oxide (NO) has been well identified as a specific free radical molecule possessing wide-ranging therapeutic effects. Targeted delivery and controlled release of NO are highly desired to realize precision gas therapy, but are still challenging owing to the non-targetability and uncontrollability of NO itself. Herein, we propose a new concept of MRI-guided and ultrasound-triggered gas release for precision gas therapy. Based on this concept, we develop a novel ultrasound-responsive BNN-type NO-releasing molecule (NORM) and an advanced rattle-type nano-carrier of superparamagnetic iron oxide-encapsulated mesoporous silica nanoparticles (SPION@hMSN), and use them to construct a new intelligent nanomedicine (BNN6-SPION@hMSN) for the first time. The BNN6-SPION@hMSN nanomedicine exhibits excellent passive tumor-targeting capability, high MRI-guided tumor localization performance and a unique ultrasound-triggered NO release profile. The tumor-targeted, MRI-guided and ultrasound-triggered release profiles of the developed nanomedicine enable the tumor site-specific controlled release of NO in favor of high-efficacy and safe NO gas therapy of tumor.
authors.affiliation: National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen 518060, Guangdong, P. R. China. nanoflower@126.com.
authors.forename: Zhaokui
authors.initials: Z
authors.lastname: Jin
authors.affiliation: National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen 518060, Guangdong, P. R. China. nanoflower@126.com.
authors.forename: Yanyuan
authors.initials: Y
authors.lastname: Wen
authors.affiliation: National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen 518060, Guangdong, P. R. China. nanoflower@126.com.
authors.forename: Yaxin
authors.initials: Y
authors.lastname: Hu
authors.affiliation: National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen 518060, Guangdong, P. R. China. nanoflower@126.com.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China.
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, P. R. China.
authors.forename: Weisheng
authors.initials: W
authors.lastname: Guo
authors.affiliation: National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen 518060, Guangdong, P. R. China. nanoflower@126.com.
authors.forename: Tianfu
authors.initials: T
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
authors.forename: Zhiyong
authors.identifier: http://orcid.org/0000-0003-2992-6424
authors.initials: Z
authors.lastname: Qian
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China.
authors.forename: Bao-Lian
authors.initials: BL
authors.lastname: Su
authors.affiliation: National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen 518060, Guangdong, P. R. China. nanoflower@126.com.
authors.forename: Qianjun
authors.identifier: http://orcid.org/0000-0003-0689-8838
authors.initials: Q
authors.lastname: He
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D053758:Nanoparticles; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009569:Nitric Oxide / Q000032:analysis*; D014463:Ultrasonography
chemical_list: D009569:Nitric Oxide