title: Enantioselective Terminal Addition to Allenes by Dual Chiral Primary Amine/Palladium Catalysis.
abstract: We herein describe a synergistic chiral primary amine/achiral palladium catalyzed enantioselective terminal addition to allenes with α-branched β-ketocarbonyls and aldehydes. The reactions afford allylic adducts bearing acyclic all-carbon quaternary centers with high regio- and enantioselectivity. A wide range of allenes including those aliphatic or 1,1'-disubstituted could be employed, thus expanding the scope of typical asymmetric allylic alkylation reactions.
authors.affiliation: Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|Department of Chemistry, University of Chinese Academy of Sciences , Beijing, 100049, China.|Collaborative Innovation Center of Chemical Science and Engineering , Tianjin, 300071, China.
authors.forename: Han
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|Department of Chemistry, University of Chinese Academy of Sciences , Beijing, 100049, China.|Collaborative Innovation Center of Chemical Science and Engineering , Tianjin, 300071, China.
authors.forename: Yaning
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|Department of Chemistry, University of Chinese Academy of Sciences , Beijing, 100049, China.|Collaborative Innovation Center of Chemical Science and Engineering , Tianjin, 300071, China.
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|Department of Chemistry, University of Chinese Academy of Sciences , Beijing, 100049, China.|Collaborative Innovation Center of Chemical Science and Engineering , Tianjin, 300071, China.
authors.forename: Mao
authors.initials: M
authors.lastname: Cai
authors.affiliation: Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|Department of Chemistry, University of Chinese Academy of Sciences , Beijing, 100049, China.|Collaborative Innovation Center of Chemical Science and Engineering , Tianjin, 300071, China.
authors.forename: Sanzhong
authors.identifier: 0000-0001-8714-4047
authors.initials: S
authors.lastname: Luo