title: Relationship of physical activity with physical function and health-related quality of life in patients having undergone allogeneic haematopoietic stem-cell transplantation.
abstract: In this study, we investigated the differences in physical activity before and after transplantation, and the relationship between physical activity and physical function and health-related quality of life (QOL) in 30 patients who underwent allogeneic haematopoietic stem cell transplantation (allo-HSCT). Duration and intensity of physical activity were quantified using a three-dimensional accelerometer. Physical function was quantified by handgrip and knee-extensor strength, with the 6-minute walk test (6MWT) used as a measure of exercise capacity. Health-related QOL was assessed using the 36-item Short-Form Health Survey. The proportion of daily activities performed at an intensity >3.0 metabolic equivalents (METs) increased significantly after allo-HSCT (p < .05). Daily activity time performed at an intensity of 1.6-2.9 METs significantly correlated only with left knee strength (p < .05). In contrast, the total number of daily steps and the proportion of activity performed at 1.6-2.9 METs and >3.0 METs were positively correlated with the 6MWT (p < .05). Additionally, physical functioning and general health subscales in health-related QOL positively correlated with daily activities performed at >3.0 METs (p < .05). Physical activity was associated with 6MWT and health-related QOL. These findings have implications for rehabilitation planning for patients undergoing allo-HSCT.
authors.affiliation: Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.|Department of Rehabilitation Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: S
authors.identifier: http://orcid.org/0000-0002-4841-948X
authors.initials: S
authors.lastname: Morishita
authors.affiliation: Division of Haematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kaida
authors.affiliation: Department of Rehabilitation, Hyogo College of Medicine Hospital, Nishinomiya, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamauchi
authors.affiliation: Department of Rehabilitation, Hyogo College of Medicine Hospital, Nishinomiya, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Wakasugi
authors.affiliation: Division of Haematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ikegame
authors.affiliation: Division of Haematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
authors.affiliation: Department of Rehabilitation Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Domen
mesh_terms: D000328:Adult; D015444:Exercise / Q000502:physiology*; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006304:Health Status; D019337:Hematologic Neoplasms / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000502:physiology; D026741:Physical Therapy Modalities; D011446:Prospective Studies; D011788:Quality of Life; D014184:Transplantation, Homologous
keywords: allogeneic haematopoietic stem cell transplantation; cancer; health-related quality of life; physical activity; physical function