title: The use of mesenchymal stromal cells in treatment of lung disorders.
abstract: The therapeutic use of mesenchymal stromal cells (MSCs) represents a promising alternative clinical strategy for treating acute and chronic lung disorders. Several preclinical reports demonstrated that MSCs can secrete multiple paracrine factors and that their immunomodulatory properties can support endothelial and epithelial regeneration, modulate the inflammatory cascade and protect lungs from damage. The effects of MSC transplantation into patients suffering from lung diseases should be fully evaluated through careful assessment of safety and associated risks, which is a prerequisite for translation of preclinical research into clinical practice. In this article, we summarize the current status of preclinical research and review initial MSC-based clinical trials for treating lung injuries and lung disorders.
authors.affiliation: Regenerative Medicine Cluster, Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Bandar Putra Bertam, 13200 Kepala Batas, Pulau Pinang, Malaysia.
authors.forename: Egi
authors.initials: E
authors.lastname: Kardia
authors.affiliation: Regenerative Medicine Cluster, Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Bandar Putra Bertam, 13200 Kepala Batas, Pulau Pinang, Malaysia.
authors.forename: Norashikin
authors.initials: N
authors.lastname: Zakaria
authors.affiliation: Regenerative Medicine Cluster, Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Bandar Putra Bertam, 13200 Kepala Batas, Pulau Pinang, Malaysia.
authors.forename: Nur Shuhaidatul
authors.initials: NS
authors.lastname: Sarmiza Abdul Halim
authors.affiliation: Stem Cell Biology & Regenerative Medicine, School of Pharmacy, University of Reading, Whiteknights, RG6 6UB Reading, UK.
authors.forename: Darius
authors.initials: D
authors.lastname: Widera
authors.affiliation: Regenerative Medicine Cluster, Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Bandar Putra Bertam, 13200 Kepala Batas, Pulau Pinang, Malaysia.
authors.forename: Badrul Hisham
authors.initials: BH
authors.lastname: Yahaya
mesh_terms: D000818:Animals; D006801:Humans; D008171:Lung Diseases / Q000628:therapy*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D012038:Regeneration / Q000502:physiology*
keywords: cell-based therapy; lung disorders; mesenchymal stem cells; mesenchymal stromal cells; safety assessment