title: Effect of pelvic organ prolapse repair on detrusor overactivity in women following incontinence surgery: A multivariate analysis.
abstract: OBJECTIVE
  To determine the effect of pelvic organ prolapse (POP) repair on post-operative detrusor overactivity (DO) in women who have underwent incontinence surgery, using multivariate analysis.
  
  
  METHODS
  A retrospective study was carried out on a cohort of 105 women who underwent incontinence surgery. In 39 of the patients this surgery was associated with pelvic organ prolapse repair. Clinical and urodynamic data were collected pre- and 3 months post-operatively. A multivariate statistical analysis was performed to detect confounding factors which could influence on the risk factors associated with post-operative detrusor overactivity.
  
  
  RESULTS
  On univariate analysis, the following pre-operative factors were associated with post-operative detrusor overactivity: symptomatic mixed urinary incontinence, rectocele, detrusor overactivity, voided volume on free uroflowmetry, maximum cystomanometric capacity, and performing concomitant pelvic organ prolapse repair. Multivariate analysis, by means of confounding factors elimination, revealed that only pre-operative rectocele and detrusor overactivity were independent risk factors.
  
  
  CONCLUSIONS
  The pelvic organ prolapse repair acts as a confounding factor. Women with a pre-operative rectocele and detrusor overactivity are on a greater risk to develop post-operative detrusor overactivity and, therefore, they should be informed.
authors.affiliation: Department of Urology, Hospital Nacional de Parapléjicos, Toledo, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Virseda-Chamorro
authors.affiliation: Department of Urology, Hospital Clínico de San Carlos, Complutense University, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Salinas-Casado
authors.affiliation: Department of Urology, Hospital Clínico de San Carlos, Complutense University, Madrid, Spain.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Tapia-Herrero
authors.affiliation: Department of Urology, Hospital Clínico de San Carlos, Complutense University, Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Pesquera
authors.affiliation: Department of Urology, Hospital Sanitas La moraleja, Madrid, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Méndez-Rubio
authors.affiliation: Department of Urology, Hospital Nacional de Parapléjicos, Toledo, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Esteban-Fuertes
authors.affiliation: Department of Urology, Hospital Clínico de San Carlos, Complutense University, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Resel-Forskelma
authors.affiliation: Department of Urology, Hospital Clínico de San Carlos, Complutense University, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Moreno-Sierra
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D056887:Pelvic Organ Prolapse / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D053201:Urinary Bladder, Overactive / Q000453:epidemiology*; D014549:Urinary Incontinence / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery*; D014550:Urinary Incontinence, Stress / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D053202:Urinary Incontinence, Urge / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D014563:Urodynamics; D013520:Urologic Surgical Procedures
keywords: overactive detrusor; pelvic organ prolapse; stress urinary incontinence; suburethral slings; urodynamics