title: Tumor-induced Osteomalacia Caused by a Parotid Tumor.
abstract: A 77-year-old man was suspected of having tumor-induced osteomalacia (TIO) because of hypophosphatemia (1.9 mg/dL) and elevated serum fibroblast growth factor 23 (FGF23) level (186.9 pg/mL). We detected a tumor in his left parotid gland, and the FGF23 level in the left external jugular vein indicated that the tumor overproduced FGF23. After the removal of the tumor, the serum FGF23 level rapidly decreased, and the serum phosphate normalized. This is the first case of TIO caused by a tumor in a parotid gland. This case indicates that the responsible tumors for TIO can be quite diverse.
authors.affiliation: Division of Nephrology and Endocrinology, The University of Tokyo Hospital, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takashi
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Ito
authors.forename: Manabu
authors.initials: M
authors.lastname: Taguchi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Naoya
authors.initials: N
authors.lastname: Egami
authors.forename: Shogo
authors.initials: S
authors.lastname: Tajima
authors.forename: Masaomi
authors.initials: M
authors.lastname: Nangaku
authors.forename: Seiji
authors.initials: S
authors.lastname: Fukumoto
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood; D006801:Humans; D017674:Hypophosphatemia / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009372:Neoplasms, Connective Tissue / Q000000981:diagnostic imaging / Q000209:etiology*; D010018:Osteomalacia; D010257:Paraneoplastic Syndromes / Q000000981:diagnostic imaging / Q000209:etiology; D010307:Parotid Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D000072078:Positron Emission Tomography Computed Tomography; D011877:Radionuclide Imaging
chemical_list: D014408:Biomarkers, Tumor; C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23