title: Timing of Surgical Resection for Curative Colorectal Cancer with Liver Metastasis.
abstract: OBJECTIVE
  Optimal surgical strategy for resectable synchronous colorectal cancer with liver metastasis (SCRLM) remains a therapeutic dilemma. Multiple retrospective studies including several meta-analyses have been published since 2001 to help facilitate the decision making process and identify the optimal surgical approach. Controversy limits the generalization of available data to draw conclusions. A review of available literature on appropriate surgical timing may alleviate confusion among physicians and promote a more evidence based approach.
  
  
  CONCLUSIONS
  Current evidence supports the feasibility, safety, and equivalent oncological outcomes of simultaneous curative resection of stage IV colorectal cancer with liver metastasis in appropriately selected patients.
authors.affiliation: Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, 55905, USA.|Division of Surgical Oncology, Ohio State University Wexner Medical Center, Columbus, OH, USA.|Colon and Rectal Surgery, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.|The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77230-1402, USA.|College of Medicine, University of Central Florida, 2501 North Orange Avenue, Orlando, FL, USA.
authors.forename: Shahzad M
authors.initials: SM
authors.lastname: Ali
authors.affiliation: Division of Surgical Oncology, Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Pawlik
authors.affiliation: The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77230-1402, USA.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Rodriguez-Bigas
authors.affiliation: College of Medicine, University of Central Florida, 2501 North Orange Avenue, Orlando, FL, USA.
authors.forename: John R T
authors.initials: JRT
authors.lastname: Monson
authors.affiliation: Colon and Rectal Surgery, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: George J
authors.initials: GJ
authors.lastname: Chang
authors.affiliation: College of Medicine, University of Central Florida, 2501 North Orange Avenue, Orlando, FL, USA. larson.david2@mayo.edu.
authors.forename: David W
authors.initials: DW
authors.lastname: Larson
mesh_terms: D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D013505:Digestive System Surgical Procedures / Q000009:adverse effects / Q000401:mortality; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery*; D059146:Metastasectomy / Q000009:adverse effects / Q000401:mortality; D011183:Postoperative Complications / Q000209:etiology; D015996:Survival Rate; D013997:Time Factors