title: The Horizon of Materiobiology: A Perspective on Material-Guided Cell Behaviors and Tissue Engineering.
abstract: Although the biological functions of cell and tissue can be regulated by biochemical factors (e.g., growth factors, hormones), the biophysical effects of materials on the regulation of biological activity are receiving more attention. In this Review, we systematically summarize the recent progress on how biomaterials with controllable properties (e.g., compositional/degradable dynamics, mechanical properties, 2D topography, and 3D geometry) can regulate cell behaviors (e.g., cell adhesion, spreading, proliferation, cell alignment, and the differentiation or self-maintenance of stem cells) and tissue/organ functions. How the biophysical features of materials influence tissue/organ regeneration have been elucidated. Current challenges and a perspective on the development of novel materials that can modulate specific biological functions are discussed. The interdependent relationship between biomaterials and biology leads us to propose the concept of "materiobiology", which is a scientific discipline that studies the biological effects of the properties of biomaterials on biological functions at cell, tissue, organ, and the whole organism levels. This Review highlights that it is more important to develop ECM-mimicking biomaterials having a self-regenerative capacity to stimulate tissue regeneration, instead of attempting to recreate the complexity of living tissues or tissue constructs ex vivo. The principles of materiobiology may benefit the development of novel biomaterials providing combinative bioactive cues to activate the migration of stem cells from endogenous reservoirs (i.e., cell niches), stimulate robust and scalable self-healing mechanisms, and unlock the body's innate powers of regeneration.
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, People's Republic of China.
authors.forename: Yulin
authors.identifier: http://orcid.org/0000-0001-5569-1038
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology , Kelvin Grove, Brisbane, Queensland 4059, Australia.
authors.forename: Yin
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, People's Republic of China.
authors.forename: Changsheng
authors.initials: C
authors.lastname: Liu
mesh_terms: D001672:Biocompatible Materials; D002448:Cell Adhesion; D019070:Cell Lineage; D002465:Cell Movement; D002477:Cells; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials