title: Harmful Effects of Hyperoxia in Postcardiac Arrest, Sepsis, Traumatic Brain Injury, or Stroke: The Importance of Individualized Oxygen Therapy in Critically Ill Patients.
abstract: The beneficial effects of oxygen are widely known, but the potentially harmful effects of high oxygenation concentrations in blood and tissues have been less widely discussed. Providing supplementary oxygen can increase oxygen delivery in hypoxaemic patients, thus supporting cell function and metabolism and limiting organ dysfunction, but, in patients who are not hypoxaemic, supplemental oxygen will increase oxygen concentrations into nonphysiological hyperoxaemic ranges and may be associated with harmful effects. Here, we discuss the potentially harmful effects of hyperoxaemia in various groups of critically ill patients, including postcardiac arrest, traumatic brain injury or stroke, and sepsis. In all these groups, there is evidence that hyperoxia can be harmful and that oxygen prescription should be individualized according to repeated assessment of ongoing oxygen requirements.
authors.affiliation: Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium.
authors.forename: Jean-Louis
authors.identifier: 0000-0001-6011-6951
authors.initials: JL
authors.lastname: Vincent
authors.affiliation: Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium.
authors.forename: Fabio Silvio
authors.identifier: 0000-0003-0830-1628
authors.initials: FS
authors.lastname: Taccone
authors.affiliation: Department of Intensive Care, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Xinrong
authors.initials: X
authors.lastname: He
mesh_terms: D000070642:Brain Injuries, Traumatic / Q000150:complications*; D003422:Critical Care; D016638:Critical Illness; D006801:Humans; D018496:Hyperoxia / Q000150:complications*; D010100:Oxygen / Q000008:administration & dosage / Q000009:adverse effects*; D057285:Precision Medicine; D018805:Sepsis / Q000150:complications*; D020521:Stroke / Q000150:complications*
chemical_list: D010100:Oxygen