title: Capsular serotypes, virulence-associated genes and antimicrobial susceptibility of Streptococcus suis isolates from pigs in Korea.
abstract: Streptococcus suis is an important pig pathogen with potential for human transmission. The serotype distributions and phenotypic characteristics vary over time and among regions; however, little is known about the characteristics of S. suis isolates in Korea. In this study, 240 S. suis isolates collected from pigs in Korea in 2009-2010 were serotyped by coagglutination tests, subsequently screened for three virulence-associated genes (mrp, epf and sly) and tested for antimicrobial susceptibility. As for 80 isolates, the serotypes of which were relevant to human infections, clonal complexes (CCs) were further identified by PCR. Serotype 3 was the most prevalent (15.8%), followed by serotype 2 (15.0%), with geographical variation for each serotype. Overall, 55.4% of the isolates carried mrp, whereas only 3.8% carried epf. CC25 was the most prevalent (41.3%) and was related to serotypes 2 and 9. The isolates showed higher susceptibility to ampicillin (93.4%) and ceftiofur (90.8%) than to the other antimicrobial agents tested. The highest resistance rate was observed to tetracycline (98.0%), followed by erythromycin (88.8%). In addition, the resistance to certain antimicrobials was significantly associated, in part, with virulence-associated genes or serotypes. Therefore, continuous characterization of S. suis is essential for the benefit of veterinary and human medicine.
authors.affiliation: Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon, 39660, Korea.|College of Veterinary Medicine, Chonbuk National University, 79 Gobong-ro, Iksan, 54596, Korea.
authors.forename: Sang-Ik
authors.initials: SI
authors.lastname: Oh
authors.affiliation: Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon, 39660, Korea.
authors.forename: Albert Byungyun
authors.initials: AB
authors.lastname: Jeon
authors.affiliation: Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon, 39660, Korea.
authors.forename: Byeong-Yeal
authors.initials: BY
authors.lastname: Jung
authors.affiliation: Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon, 39660, Korea.
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Byun
authors.affiliation: Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montréal, St-Hyacinthe, Québec, J2S 2M2, Canada.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Gottschalk
authors.affiliation: Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon, 39660, Korea.
authors.forename: Aeran
authors.initials: A
authors.lastname: Kim
authors.affiliation: Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon, 39660, Korea.
authors.forename: Jong Wan
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon, 39660, Korea.
authors.forename: Ha-Young
authors.initials: HY
authors.lastname: Kim
mesh_terms: D000003:Abattoirs; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016667:Bacterial Capsules / Q000276:immunology*; D024881:Drug Resistance, Bacterial; D005798:Genes, Bacterial; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D056910:Republic of Korea; D012703:Serotyping; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D017011:Streptococcus suis / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000382:microbiology*; D014774:Virulence / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents
keywords: Streptococcus suis; antimicrobial susceptibility; clonal complex; serotype; virulence-associated gene