title: Novel pre-therapeutic scoring system using patient and haematological data to predict facial palsy prognosis.
abstract: OBJECTIVE
  We describe a novel scoring system, the facial Palsy Prognosis Prediction score (PPP score), which we test for reliability in predicting pre-therapeutic prognosis of facial palsy. We aimed to use readily available patient data that all clinicians have access to before starting treatment.
  
  
  METHODS
  Multicenter case series with chart review.
  
  
  METHODS
  Three tertiary care hospitals.
  
  
  METHODS
  We obtained haematological and demographic data from 468 facial palsy patients who were treated between 2010 and 2014 in three tertiary care hospitals. Patients were categorised as having Bell's palsy or Ramsey Hunt's palsy.
  
  
  METHODS
  We compared the data of recovered and unrecovered patients. PPP scores consisted of combinatorial threshold values of continuous patient data (eg platelet count) and categorical variables (eg gender) that best predicted recovery. We created separate PPP scores for Bell's palsy patients (PPP-B) and for Ramsey Hunt's palsy patients (PPP-H).
  
  
  RESULTS
  The PPP-B score included age (≥65 years), gender (male) and neutrophil-to-lymphocyte ratio (≥2.9). The PPP-H score included age (≥50 years), monocyte rate (≥6.0%), mean corpuscular volume (≥95 fl) and platelet count (≤200 000 /μL). Patient recovery rate significantly decreased with increasing PPP scores (both PPP-B and PPP-H) in a step-wise manner. PPP scores (ie PPP-B score and PPP-H score) ≥2 were associated with worse than average prognosis.
  
  
  CONCLUSIONS
  Palsy Prognosis Prediction scores are useful for predicting prognosis of facial palsy before beginning treatment.
authors.affiliation: Department of Otolaryngology, Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan.|Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.|Department of Otolaryngology - Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: K
authors.identifier: http://orcid.org/0000-0001-7335-3622
authors.initials: K
authors.lastname: Wasano
authors.affiliation: Department of Otolaryngology, Nippon Koukan Hospital, Kanagawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.affiliation: Department of Otolaryngology, Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kawasaki
authors.affiliation: Department of Otolaryngology, Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.affiliation: Department of Otolaryngology, Nippon Koukan Hospital, Kanagawa, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tomisato
authors.affiliation: Department of Otolaryngology, Saiseikai Utsunomiya Hospital, Tochigi, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shinden
authors.affiliation: Department of Otolaryngology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Minami
authors.affiliation: Department of Otolaryngology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Wakabayashi
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D020330:Bell Palsy / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D001772:Blood Cell Count; D005158:Facial Paralysis / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D016697:Herpes Zoster Oticus / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D020127:Recovery of Function; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D015415:Biomarkers