title: Dietary fat quantity and quality modifies advanced glycation end products metabolism in patients with metabolic syndrome.
abstract: Advanced glycation end products (AGEs) increase in dysmetabolic conditions. Lifestyle, including diet, has shown be effective in preventing the development of metabolic syndrome (MetS). We investigated whether AGE metabolism is affected by diets with different fat quantity and quality in MetS patients.
  
  
  
  A randomized, controlled trial assigned 75 MetS patients to one of four diets: high SFA (HSFA), high MUFA (HMUFA), and two low-fat, high-complex carbohydrate diets (LFHCC) supplemented with long-chain n-3 PUFA or placebo for 12-weeks each. Dietary and serum AGE [methylglyoxal (MG: lysine-MG-H1) and N-carboxymethyllysine] levels and gene expression related to AGE metabolism in peripheral blood mononuclear cells (AGER1, RAGE, GloxI, and Sirt1 mRNA) were determined. HMUFA diet reduced serum AGE (sAGE) and RAGE mRNA, increased AGER1 and GloxI mRNA levels compared to the other diets. LFHCC n-3 diet reduced sAGE levels and increased AGER1 mRNA levels compared to LFHCC and HSFA diets. Multiple regression analyses showed that sMG and AGER1 mRNA appeared as significant predictors of oxidative stress/inflammation-related parameters.
  
  
  
  Low AGE content in HMUFA diet reduces sAGEs and modulates the gene expression related to AGE metabolism in MetS patients, which may be used as a therapeutic approach to reduce the incidence of MetS and related chronic diseases.
authors.affiliation: Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain.|CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Lopez-Moreno
authors.affiliation: Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain.|CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Spain.
authors.forename: Gracia M
authors.initials: GM
authors.lastname: Quintana-Navarro
authors.affiliation: Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain.|CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Camargo
authors.affiliation: Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain.|CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Jimenez-Lucena
authors.affiliation: Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain.|CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Delgado-Lista
authors.affiliation: Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain.|CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Marin
authors.affiliation: CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Spain.|Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria Hospital, University of Malaga, Malaga, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Tinahones
authors.affiliation: Division of Experimental Diabetes and Aging, Department of Geriatrics, Divisions of Icahn School of Medicine at Mount Sinai, New York, USA.
authors.forename: Gary E
authors.initials: GE
authors.lastname: Striker
authors.affiliation: Nutrigenomics Research Group, UCD Conway Institute/UCD Institute of Food and Health, School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Roche
authors.affiliation: Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain.|CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Perez-Martinez
authors.affiliation: Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain.|CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Lopez-Miranda
authors.affiliation: Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain.|CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Spain.
authors.forename: Elena M
authors.initials: EM
authors.lastname: Yubero-Serrano
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics; D004041:Dietary Fats / Q000032:analysis / Q000494:pharmacology*; D005260:Female; D005786:Gene Expression Regulation; D017127:Glycation End Products, Advanced / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000178:diet therapy* / Q000378:metabolism* / Q000517:prevention & control; D008875:Middle Aged; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics; D018384:Oxidative Stress; D012307:Risk Factors; D056564:Sirtuin 1 / Q000235:genetics
chemical_list: D000951:Antigens, Neoplasm; D004041:Dietary Fats; D017127:Glycation End Products, Advanced; C498978:MOK protein, human; D020928:Mitogen-Activated Protein Kinases; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Advanced glycation end products; Dietary fat; Inflammation; Metabolic syndrome; Oxidative stress