title: VDRmRNA overexpression is associated with worse prognostic factors in papillary thyroid carcinoma.
abstract: The purpose of this study was to assess the relationship between vitamin D receptor gene (VDR) expression and prognostic factors in papillary thyroid cancer (PTC). mRNA sequencing and somatic mutation data from The Cancer Genome Atlas (TCGA) were analyzed.VDRmRNA expression was compared to clinicopathologic variables by linear regression. Tree-based classification was applied to find cutoff and patients were split into low and highVDRgroup. Logistic regression, Kaplan-Meier analysis, differentially expressed gene (DEG) test and pathway analysis were performed to assess the differences between twoVDRgroups.VDRmRNA expression was elevated in PTC than that in normal thyroid tissue.VDRexpressions were high in classic and tall-cell variant PTC and lateral neck node metastasis was present. HighVDRgroup was also associated with classic and tall cell subtype, AJCC stage IV and lower recurrence-free survival. DEG test reveals that 545 genes were upregulated in highVDRgroup. Thyroid cancer-related pathways were enriched in highVDRgroup in pathway analyses.VDRmRNA overexpression was correlated with worse prognostic factors such as subtypes of papillary thyroid carcinoma that are known to be worse prognosis, lateral neck node metastasis, advanced stage and recurrence-free survival.
authors.affiliation: Department of SurgerySeoul National University Bundang Hospital, Seongnam-si, Korea.
authors.forename: June Young
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Department of SurgerySeoul National University Hospital and College of Medicine, Seoul, Korea.
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Yi
authors.affiliation: Department of SurgerySeoul National University Hospital and College of Medicine, Seoul, Korea.
authors.forename: Jun Hyup
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of SurgerySeoul National University Hospital and College of Medicine, Seoul, Korea.
authors.forename: Ra-Yeong
authors.initials: RY
authors.lastname: Song
authors.affiliation: Department of SurgerySeoul National University Bundang Hospital, Seongnam-si, Korea.
authors.forename: Hyeongwon
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of SurgerySeoul National University Hospital and College of Medicine, Seoul, Korea.
authors.forename: Hyungju
authors.initials: H
authors.lastname: Kwon
authors.affiliation: Department of SurgerySeoul National University Boramae Hospital, Seoul, Korea.
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Chai
authors.affiliation: Department of SurgerySeoul National University Hospital and College of Medicine, Seoul, Korea.
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of SurgerySeoul National University Hospital and College of Medicine, Seoul, Korea kyueunlee@snu.ac.kr.
authors.forename: Kyu Eun
authors.initials: KE
authors.lastname: Lee
keywords: TCGA data; VDR mRNA; papillary thyroid carcinoma; vitamin D