title: Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population.
abstract: Left ventricular remodeling is an essential risk factor contributing to the pathogenesis of chronic heart failure (CHF). Basigin (BSG) promotes cardiovascular inflammation and myocardial remodeling processes by induction of extracellular matrix metalloproteinases and inflammatory cytokines.BSGrs8259 polymorphism was associated with BSG expression and risk of acute coronary syndrome. Therefore, we investigated whether rs8259 polymorphism contributes to risk and prognosis of CHF in Chinese patients. In total 922 adult patients with CHF and 1107 matched healthy controls were enrolled.BSGrs8259 polymorphism was genotyped using PCR-restriction fragment length polymorphism. Whole bloodBSGmRNA expression data from Genotype-Tissue Expression project was accessed. Evaluation of follow-up data was performed in only 15.2% (140) of the patients with CHF.BSGrs8259 TT genotype was associated with a decreased risk of CHF (OR = 0.83, 95% CI = 0.72-0.96,p= 0.010), especially in patients with hypertension (OR = 0.80, 95% CI = 0.68-0.95,p= 0.011) and coronary heart disease (OR = 0.81, 95% CI = 0.69-0.96,p= 0.013) after adjustment for multiple cardiovascular risk factors. Rs8259 T allele was associated with decreasedBSGmRNA in whole blood from 338 healthy normal donors (p= 1.31 × 10-6). However, rs8259 polymorphism failed to exhibit an association with cardiovascular mortality (p= 0.283).BSGrs8259 polymorphism may contribute to decreased risk of CHF in a Chinese Han population.
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. elskesunny@163.com.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China. elskesunny@163.com.
authors.forename: Mu-Peng
authors.initials: MP
authors.lastname: Li
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. huxiaolei66@126.com.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China. huxiaolei66@126.com.
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Hu
authors.affiliation: Haikou People's Hospital and Affiliated Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570311, China. yyl0756@yeah.net.
authors.forename: Yong-Long
authors.initials: YL
authors.lastname: Yang
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. zhangyj287112687@163.com.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China. zhangyj287112687@163.com.
authors.forename: Yan-Jiao
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. zhoujipeng0506@163.com.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China. zhoujipeng0506@163.com.
authors.forename: Ji-Peng
authors.initials: JP
authors.lastname: Zhou
authors.affiliation: Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. hsogin@aliyun.com.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Peng
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. chenxp74@hotmail.com.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China. chenxp74@hotmail.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. jietang@csu.edu.cn.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China. jietang@csu.edu.cn.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics; D051926:Basigin / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002908:Chronic Disease; D005260:Female; D005838:Genotype; D006333:Heart Failure / Q000208:ethnology / Q000235:genetics* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000096:biosynthesis; D012307:Risk Factors; D055815:Young Adult
chemical_list: D012333:RNA, Messenger; D051926:Basigin
keywords: Basigin; chronic heart failure; polymorphism; prognosis