title: Impairment of Energy-Dependent Processes in the Muscle Tissue as a Pathogenetic Mechanism of Statin-Induced Myopathy.
abstract: Administration of simvastatin was followed by a decrease in activities of superoxide dismutase and cytochrome oxidase in rat mitochondria, which attested to dysfunction of the respiratory chain. The decrease in total ATPase and Ca2+-ATPase activities in muscle tissue homogenates reflected impaired transport of active cations essential for muscle contraction. We conclude that abnormal relationships in the system of energy synthetic and energy-dependent processes in myocytes serve as the molecular basis for the formation of statin-induced degenerative changes.
authors.affiliation: Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
authors.forename: Z I
authors.initials: ZI
authors.lastname: Mikashinovich
authors.affiliation: Department of Pharmaceutical Chemistry and Pharmacognosy, Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia. belousovalena@mail.ru.
authors.forename: E S
authors.initials: ES
authors.lastname: Belousova
authors.affiliation: Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
authors.forename: O G
authors.initials: OG
authors.lastname: Sarkisyan
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D000924:Anticholesteremic Agents / Q000009:adverse effects*; D004579:Electron Transport / Q000187:drug effects; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009135:Muscular Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D051381:Rats; D019821:Simvastatin / Q000009:adverse effects*; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000924:Anticholesteremic Agents; D019821:Simvastatin; D013482:Superoxide Dismutase; D003576:Electron Transport Complex IV
keywords: simvastatin; skeletal muscles; statin-induced myopathy; statins