title: The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex.
abstract: Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in depression. The changes in neural plasticity induced by stress and other negative stimuli play a significant role in the onset and development of depression. Antidepressant treatments have also been found to exert their antidepressant effects through regulatory effects on neural plasticity. However, the detailed mechanisms of neural plasticity in depression still remain unclear. Therefore, in this review, we summarize the recent literature to elaborate the possible mechanistic role of neural plasticity in depression. Taken together, these findings may pave the way for future progress in neural plasticity studies.
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China; Anesthesiology Department, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Wei
authors.identifier: 0000-0003-0894-4930
authors.initials: W
authors.lastname: Liu
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Tongtong
authors.identifier: 0000-0002-4559-213X
authors.initials: T
authors.lastname: Ge
authors.affiliation: Anesthesiology Department, The Third Hospital of Jilin University, 126 Xiantai Street, Changchun 130033, China.
authors.forename: Yashu
authors.identifier: 0000-0002-4615-0317
authors.initials: Y
authors.lastname: Leng
authors.affiliation: Anesthesiology Department, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Zhenxiang
authors.initials: Z
authors.lastname: Pan
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Jie
authors.identifier: 0000-0002-8461-6093
authors.initials: J
authors.lastname: Fan
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Wei
authors.identifier: 0000-0002-3944-4536
authors.initials: W
authors.lastname: Yang
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Ranji
authors.identifier: 0000-0002-1129-3772
authors.initials: R
authors.lastname: Cui
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000503:physiopathology; D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology*; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology*; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D055495:Neurogenesis / Q000187:drug effects; D009473:Neuronal Plasticity / Q000187:drug effects; D017397:Prefrontal Cortex / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D000928:Antidepressive Agents