title: Within-Host Sampling of a Natural Population Shows Signs of Selection on Pde1 during Bacterial Meningitis.
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
authors.forename: John A
authors.identifier: http://orcid.org/0000-0001-5360-1254
authors.initials: JA
authors.lastname: Lees
authors.affiliation: Department of Neurology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Matthijs
authors.identifier: http://orcid.org/0000-0001-7775-7843
authors.initials: M
authors.lastname: Brouwer
authors.affiliation: Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.|Netherlands Reference Laboratory for Bacterial Meningitis, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Arie
authors.initials: A
authors.lastname: van der Ende
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
authors.forename: Julian
authors.identifier: http://orcid.org/0000-0002-7069-5958
authors.initials: J
authors.lastname: Parkhill
authors.affiliation: Department of Neurology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Diederik
authors.initials: D
authors.lastname: van de Beek
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom sdb@sanger.ac.uk.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Bentley
mesh_terms: D000328:Adult; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1 / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D008586:Meningitis, Pneumococcal / Q000382:microbiology* / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000276:immunology; D000069456:Silent Mutation / Q000235:genetics; D013296:Streptococcus pneumoniae / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics
chemical_list: D022242:Pneumococcal Vaccines; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1
keywords: DHH family protein; bacterial meningitis; pde1; pneumococcal pathogenesis; selection