title: The Association Between Leukoaraiosis and Poor Outcome in Intracerebral Hemorrhage Is Not Mediated by Hematoma Growth.
abstract: BACKGROUND
  The significance of white matter lesions (WMLs) in intracerebral hemorrhage (ICH) remains unclear. We investigated the effects of WML on initial hematoma volume, hematoma growth, intraventricular extension, and clinical outcome in patients with spontaneous ICH.
  
  
  METHODS
  Computed tomography scans of 262 patients included in a placebo arm of a prospective, multicenter trial were used for a semi-quantitative analysis of white matter changes. A logistic regression analysis was used to explore the effects on hematoma volume, volume changes, intraventricular hemorrhage, and clinical outcome after 90 days.
  
  
  RESULTS
  The degree of WML was not associated with initial hematoma volume, absolute and relative hematoma growth, hematoma growth >33% or >6 mL, or with intraventricular extension. WML significantly increased the odds for poor outcome after 90 days (adjusted OR 1.4, 95% CI 1.1-1.8, P = .02).
  
  
  CONCLUSIONS
  WMLs were not associated with initial hematoma volume, hematoma growth, or intraventricular extension. WMLs were associated with poor outcome independently.
authors.affiliation: Department of Neurology, Heidelberg University, Germany; Department of Neurocritical Care, Sigmund Freud Privatuniversität, Vienna, Austria. Electronic address: mareksykora@yahoo.com.
authors.forename: Marek
authors.initials: M
authors.lastname: Sykora
authors.affiliation: Department of Neuroradiology, Heidelberg University, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Herweh
authors.affiliation: Department of Neurocritical Care, Sigmund Freud Privatuniversität, Vienna, Austria; Department of Neurology, Klinikum Frankfurt Höchst, Frankfurt, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Steiner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging* / Q000628:therapy; D018450:Disease Progression; D005260:Female; D006801:Humans; D049292:Leukoaraiosis / Q000000981:diagnostic imaging*; D056784:Leukoencephalopathies / Q000000981:diagnostic imaging*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D014057:Tomography, X-Ray Computed
keywords: Intracerebral hemorrhage; hemorrhage growth; leukoaraiosis; outcome; small vessel disease; white matter lesions