title: Two Cases of Primary Sclerosing Cholangitis Overlapping with Autoimmune Hepatitis in Adults.
abstract: Overlap syndrome between primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) is extremely rare in Japan. We herein report two adult patients with PSC-AIH overlap syndrome. They were diagnosed with PSC-AIH overlap syndrome based on the findings of endoscopic retrograde cholangiography and liver biopsy, and using the International Autoimmune Hepatitis Group scoring system. In both cases, PSC preceded AIH, and combination therapy with steroid and ursodeoxycholic acid was effective. Because there are few reported cases in Japan, it is important to study more cases to shed light on the clinical and pathological features of PSC-AIH overlap syndrome.
authors.affiliation: Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine, Japan.
authors.forename: Go
authors.initials: G
authors.lastname: Igarashi
authors.forename: Tetsu
authors.initials: T
authors.lastname: Endo
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Mikami
authors.forename: Naoya
authors.initials: N
authors.lastname: Sawada
authors.forename: Ryu
authors.initials: R
authors.lastname: Satake
authors.forename: Rie
authors.initials: R
authors.lastname: Ohta
authors.forename: Juichi
authors.initials: J
authors.lastname: Sakamoto
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Akira
authors.initials: A
authors.lastname: Kurose
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kijima
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Fukuda
mesh_terms: D001706:Biopsy; D002758:Cholangiography; D015209:Cholangitis, Sclerosing / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000627:therapeutic use; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014057:Tomography, X-Ray Computed; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D014580:Ursodeoxycholic Acid