title: Lower respiratory tract viral infections: Diagnostic role of exfoliative cytology.
abstract: Viral lower respiratory tract infections (VLRTI) remain one of the most common causes of morbidity and mortality worldwide. For many years, the diagnosis of VLRTI was based on laboratory techniques such as viral isolation in cell culture, antigen detection by direct fluorescent antibody staining, and rapid enzyme immunoassay. Radiological imaging and morphology also play an important role in diagnosing these infections. Exfoliative cytology provides a simple, rapid, inexpensive, and valuable means to diagnose and manage VLRTI. Here we review viral-associated cytomorphological changes seen in exfoliated cells of the lower respiratory tract. Diagn. Cytopathol. 2017;45:614-620. © 2017 Wiley Periodicals, Inc.
authors.affiliation: INCLÍNICA Foundation for Clinical, Pneumological and Carcinogenic Research, Oviedo, 16. 33007, Spain.
authors.forename: Rafael
authors.identifier: http://orcid.org/0000-0002-8972-2434
authors.initials: R
authors.lastname: Martínez-Girón
authors.affiliation: Department of Pathology, UPMC Shadyside, UPMC Cancer Pavilion Suite 201, Pittsburgh, Pennsylvania.
authors.forename: Liron
authors.initials: L
authors.lastname: Pantanowitz
mesh_terms: D000911:Antibodies, Monoclonal / Q000737:chemistry; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D003588:Cytopathogenic Effect, Viral; D004801:Eosine Yellowish-(YS) / Q000737:chemistry; D015726:Giant Cells / Q000473:pathology / Q000821:virology*; D006416:Hematoxylin / Q000737:chemistry; D006651:Histocytochemistry / Q000379:methods*; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D012137:Respiratory System / Q000473:pathology / Q000821:virology; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D013183:Sputum / Q000166:cytology; D014777:Virus Diseases / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D014780:Viruses / Q000254:growth & development / Q000472:pathogenicity*
chemical_list: D000911:Antibodies, Monoclonal; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin
keywords: diagnosis; exfoliative cytology; lower respiratory tract infections; viruses