title: The Use of Chinese Herbal Medicine in the Treatment of Chronic Obstructive Pulmonary Disease (COPD).
abstract: In Oriental countries, combinations of Chinese herbal products (CHPs) are often utilized as therapeutic agents for chronic obstructive pulmonary disease (COPD). The effects of CHPs on COPD have been previously reported. This study aimed to analyze the frequency of prescription and usage of CHPs in patients with COPD in Taiwan. In this nationwide population-based cross-sectional study, 19,142 patients from a random sample of one million individuals in the Longitudinal Health Insurance Database 2000 (LHID 2000) of the National Health Insurance Research Database (NHIRD) were enrolled from 2000 to 2011. The multiple logistic regression method was used to evaluate the adjusted odds ratios for the utilization of CHPs. For patients with COPD, there was an average of 6.31 CHPs in a single prescription. The most frequently prescribed CHP for COPD was Xiao-Qing-Long-Tang (XQLT) (2.6%), and the most commonly used combination of two formula CHPs was XQLT with Ma-Xing-Gan-Shi-Tang (MXGST) (1.28%). The most commonly used single CHP for COPD was Bulbus Fritillariae (3.65%), and the most commonly used combination of two single CHPs was Bulbus Fritillariae with Puerariae Lobatae (1.09%). These results provide information regarding personalized therapies and may promote further clinical experiments and pharmacologic research on the use of CHPs for the management of COPD. Furthermore, we found that TCM usage was more prevalent among men, younger, manual workers, residents of Northern Taiwan, and patients with chronic bronchitis and asthma. This information on the distribution of TCM usage around the country is valuable to public health policymakers and clinicians.
authors.affiliation: * Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and School of Traditional Chinese Medicine Chang Gung, University College of Medicine, Kaohsiung, No. 123, Dapi Road, Niaosong District, Kaohsiung 833, Taiwan.
authors.forename: Yen-Nung
authors.initials: YN
authors.lastname: Liao
authors.affiliation: * Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and School of Traditional Chinese Medicine Chang Gung, University College of Medicine, Kaohsiung, No. 123, Dapi Road, Niaosong District, Kaohsiung 833, Taiwan.|† Kaohsiung Medical University College of Medicine, Kaohsiung, Taiwan No. 100, Shihcyuan 1st Road, Sanmin District, Kaohsiung, Taiwan.|‡ Fooyin University College of Nursing Kaohsiung, Taiwan No. 151, Chinhsueh Rd., Ta-liao District, Kaohsiung 831, Taiwan.
authors.forename: Wen-Long
authors.initials: WL
authors.lastname: Hu
authors.affiliation: § Management Office for Health Data, China Medical University Hospital, Taichung, No. 2, Yuh-Der Road, Taichung 40447, Taiwan.|¶ College of Medicine, China Medical University, Taichung, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan.
authors.forename: Hsuan-Ju
authors.initials: HJ
authors.lastname: Chen
authors.affiliation: * Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and School of Traditional Chinese Medicine Chang Gung, University College of Medicine, Kaohsiung, No. 123, Dapi Road, Niaosong District, Kaohsiung 833, Taiwan.|∥ School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, No. 1, Sec. 1, Syuecheng Road, Dashu District, Kaohsiung 84001, Taiwan.
authors.forename: Yu-Chiang
authors.initials: YC
authors.lastname: Hung
mesh_terms: D000328:Adult; D000367:Age Factors; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D004359:Drug Therapy, Combination; D004363:Drug Utilization / Q000706:statistics & numerical data*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D055656:Prescriptions / Q000706:statistics & numerical data*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D012737:Sex Factors; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal; C000591856:ma-xing-shi-gan-tang; C090832:sho-seiryu-to
keywords: Chinese Herbal Products; Chronic Obstructive Pulmonary Disease; Couplet Medicinal; Pharmacoepidemiology; Prescription Pattern