title: Histologic transformation of EGFR mutant lung adenocarcinoma without exposure to EGFR inhibition.
abstract: Resistance to EGFR kinase inhibitors appears to be invariable in the treatment of non-small cell lung cancer. Several mechanisms have been described. Here, we report the first case of histologic transformation of EGFR mutant lung adenocarcinoma without prior exposure to EGFR inhibition.
authors.affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
authors.forename: Tri
authors.initials: T
authors.lastname: Le
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
authors.forename: Joseph
authors.initials: J
authors.lastname: Sailors
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States; The Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
authors.forename: Dwight H
authors.initials: DH
authors.lastname: Oliver
authors.affiliation: The Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
authors.forename: Melissa
authors.initials: M
authors.lastname: Mayer
authors.affiliation: The Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
authors.forename: Sharon
authors.initials: S
authors.lastname: Hoskin
authors.affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States; The Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, United States. Electronic address: david.gerber@utsouthwestern.edu.
authors.forename: David E
authors.initials: DE
authors.lastname: Gerber
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D000077192:Adenocarcinoma of Lung; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000235:genetics; D059248:Chemoradiotherapy; D018450:Disease Progression; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D009154:Mutation; D017384:Sequence Deletion; D019616:Thoracic Surgical Procedures
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: Adenocarcinoma NSCLC; EGFR; Squamous NSCLC