title: Non-HDL-cholesterol and C-reactive protein in children and adolescents with type 1 diabetes.
abstract: BACKGROUND
  To what extent high sensitivity C-reactive protein (hsCRP) is associated with known cardiovascular risk factors in children with type 1 diabetes (T1D) has not been fully explored.
  
  
  METHODS
  Forty-two T1D children (age: 12+/-1 years) without hypertension, retinopathy, hypothyroidism, albuminuria or other endocrine diseases and 20 controls were studied. Out of the 42 T1D patients studied 57% were prepubertal or early pubertal (Tanner I/II), 38% were pubertal (Tanner III/IV) and 5% post-pubertal (Tanner V).
  
  
  RESULTS
  Children with T1D showed higher hsCRP than controls [0.51 (0.31-1.71 vs. 0.20 (0.20-0.90) mg/L, p<0.05]. However, hsCRP levels were not different in subgroup analysis [hemoglobin A1c (HbA1c)>7.5% or disease duration>3 years] within the group of children with T1D. Conversely, non-high density lipoprotein (HDL)-cholesterol was different in the subgroup analysis. Moreover non-HDL-cholesterol was correlated with age (r=0.37, p<0.01), disease duration (r=0.36, p<0.01) and fasting glucose (r=0.55, p<0.0001).
  
  
  CONCLUSIONS
  Non-HDL-cholesterol might be more useful than hsCRP to evaluate future cardiovascular risk in children with T1D.
authors.forename: María Mercedes
authors.initials: MM
authors.lastname: Prado
authors.forename: Teresita
authors.initials: T
authors.lastname: Carrizo
authors.forename: Adela Victoria
authors.initials: AV
authors.lastname: Abregú
authors.forename: Tomás
authors.initials: T
authors.lastname: Meroño
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002097:C-Reactive Protein; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D014280:Triglycerides; C517652:hemoglobin A1c protein, human