title: Evaluation of renal function in a specific population of living kidney donors.
abstract: BACKGROUND
  The increase in candidates for kidney transplant has led to growth in the number of living donor transplants. Therefore, studies that adequately evaluate the possible long-term consequences of elective transplant nephrectomy are needed.
  
  
  OBJECTIVE
  To evaluate the possible long-term adverse effects of transplant nephrectomy on the renal function of living kidney donors.
  
  
  METHODS
  A cross-sectional study.
  
  
  METHODS
  Thirty-three living kidney donors registered in the transplant programme of a centre in Alagoas, Brazil.
  
  
  METHODS
  Demographic characteristics, anthropometric measures, clinical data and biomarkers (creatinine, eGFR, microalbuminuria, cholesterol and triglycerides) were measured. Creatinine clearance was calculated using the Cockcroft-Gault and Modification of Diet in Renal Disease formulae.
  
  
  RESULTS
  Of the 33 individuals, 63.63% were female, and the median age was 45 years. Additionally, 24.24% of these individuals had altered blood pressure, 39.39% had altered abdominal circumference (AC) and 36.36% were obese, with a body mass index ≥30. Furthermore, 33.33% of these individuals had elevated triglyceride levels. The average eGFR was 97.33 (33.03-175.9) ml/min/1.73 m2(CG) and 84.14 (29.4-131) ml/min/1.73 m2(MDRD). The microalbuminuria level was altered in 12.12% patients.
  
  
  CONCLUSIONS
  Kidney donation is unquestionably a safe procedure. However, a better understanding of the long-term consequences of living donor kidney transplantation is still needed. This knowledge may have important implications for the follow-up of these patients. Our study has demonstrated a non-negligible presence of an early marker of glomerular injury and a decrease in the GFR of some patients, thereby reinforcing the proposal for long-term follow-up of living kidney donors.
authors.affiliation: Alagoas State University of Health Science, Maceió, Alagoas, Brazil.
authors.forename: Thalyta
authors.initials: T
authors.lastname: de Souza Rodrigues
authors.affiliation: School of Medicine, Federal University of Alagoas, Maceió, Alagoas, Brazil.
authors.forename: Ana Letícia
authors.initials: AL
authors.lastname: Amorim de Albuquerque
authors.affiliation: School of Medicine, Federal University of Alagoas, Maceió, Alagoas, Brazil.
authors.forename: Fillipe Agra
authors.initials: FA
authors.lastname: de Oliveira Cosme
authors.affiliation: Alagoas State University of Health Science, Maceió, Alagoas, Brazil.
authors.forename: José Ayrton Macedo Guimarães
authors.initials: JAMG
authors.lastname: de Oliveira
authors.affiliation: Manoel André Hospital Complex, Alagoas, Brazil.
authors.forename: Indalécio
authors.initials: I
authors.lastname: Magalhães
authors.affiliation: Alagoas State University of Health Science, Maceió, Alagoas, Brazil.|School of Medicine, Federal University of Alagoas, Maceió, Alagoas, Brazil.
authors.forename: Flávio
authors.initials: F
authors.lastname: Teles
authors.affiliation: Alagoas State University of Health Science, Maceió, Alagoas, Brazil.|School of Medicine, Federal University of Alagoas, Maceió, Alagoas, Brazil.
authors.forename: André Falcão
authors.initials: AF
authors.lastname: Pedrosa
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000652:urine; D001794:Blood Pressure; D015992:Body Mass Index; D001938:Brazil; D003404:Creatinine / Q000032:analysis / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D019520:Living Donors / Q000706:statistics & numerical data*; D000069451:Long Term Adverse Effects; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000534:rehabilitation / Q000592:standards; D020858:Tissue and Organ Harvesting / Q000009:adverse effects
chemical_list: D003404:Creatinine
keywords: Chronic kidney disease; Kidney transplantation; Living donors