title: Bidirectional Crosstalk between Lymphatic Endothelial Cell and T Cell and Its Implications in Tumor Immunity.
abstract: Lymphatic vessels have been traditionally considered as passive transporters of fluid and lipids. However, it is apparent from recent literature that the function of lymphatic vessels is not only restricted to fluid balance homeostasis but also extends to regulation of immune cell trafficking, antigen presentation, tolerance, and immunity, all which may impact the progression of inflammatory responses and diseases such as cancer. The lymphatic system and the immune system are intimately connected, and there is emergent evidence for a crosstalk between T cell and lymphatic endothelial cell (LEC). This review describes how LECs in lymph nodes can affect multiple functional properties of T cells and the impact of these LEC-driven effects on adaptive immunity and, conversely, how T cells can modulate LEC growth. The significance of such crosstalk between T cells and LECs in cancer will also be discussed.
authors.affiliation: Immunology Programme, Department of Microbiology and Immunology, Yoon Loo Lin School of Medicine, Life Science Institute, National University of Singapore , Singapore , Singapore.
authors.forename: Kim Pin
authors.initials: KP
authors.lastname: Yeo
authors.affiliation: Immunology Programme, Department of Microbiology and Immunology, Yoon Loo Lin School of Medicine, Life Science Institute, National University of Singapore , Singapore , Singapore.
authors.forename: Veronique
authors.initials: V
authors.lastname: Angeli
keywords: T cell; cancer; cytokine; inflammation; lymph node; lymphatic endothelial cells; tolerance