title: Effectiveness of Bronchofiberoscopy in Diagnosis of Lung Lesions.
abstract: Lung cancer is the most common cause of cancer-related deaths. A short survival rate often results from belated diagnosis made in advanced stages. Therapy individualization requires the collection of a viable material for histopathological examination, which often brings difficulties. This study was performed in a group of 110 patients suspected of malignancy in chest computed tomography. All subjects underwent bronchofiberoscopy. Bronchoalveolar lavage (BAL) and endobronchial brushing were performed in all cases, whereas forceps tissue biopsy was taken if mucous membrane abnormalities were observed. In case of a negative result of bronchofiberoscopy invasive methods were implemented. A malignant neoplasm was diagnosed in 106 cases. Overall, cancer cells (positive result) were found in 45 patients (42.0%) subjected to bronchofiberoscopy. Cytology was positive in 38 (35.8%) and histopathological examination in 30 (28.3%) specimens. Eleven samples of BAL (10.3%) were positive. Endobronchial brushing was more effective, with 27 positive samples (25.5%). Forceps tissue biopsy was performed in 33 cases with 90% sensitivity. The most frequent cancer subtype found was squamous cell carcinoma. No severe complications of bronchofiberoscopy were observed. We conclude that bronchofiberosocpy is a safe diagnostic procedure for lung lesions, but its sensitivity and specificity are low. Only when there are mucous macroscopic changes observed, a precise diagnosis is possible.
authors.affiliation: Division of Pneumology, Department of Internal Medicine, Fourth Military Teaching Hospital, 5 Weigla Street, 50-981, Wroclaw, Poland. a.nahorecki@gmail.com.|Department of Angiology, Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, 51-618, Wroclaw, Poland. a.nahorecki@gmail.com.
authors.forename: Artur
authors.initials: A
authors.lastname: Nahorecki
authors.affiliation: Division of Pneumology, Department of Internal Medicine, Fourth Military Teaching Hospital, 5 Weigla Street, 50-981, Wroclaw, Poland.|Department of Angiology, Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, 51-618, Wroclaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Postrzech-Adamczyk
authors.affiliation: Department of Rheumatology and Internal Medicine, Wroclaw Medical University, 213 Borowska Street, 50-556, Wroclaw, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Straszak
authors.affiliation: Division of Pneumology, Department of Internal Medicine, Fourth Military Teaching Hospital, 5 Weigla Street, 50-981, Wroclaw, Poland.|Department of Angiology, Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, 51-618, Wroclaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Szuba
authors.affiliation: Division of Surgical Procedures, Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, 51-618, Wroclaw, Poland.|Department of Surgery, Fourth Military Teaching Hospital, 5 Weigla Street, 50-981, Wroclaw, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Janczak
authors.affiliation: Division of Surgical Procedures, Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, 51-618, Wroclaw, Poland.|Department of Surgery, Fourth Military Teaching Hospital, 5 Weigla Street, 50-981, Wroclaw, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Chabowski
mesh_terms: D000368:Aged; D001706:Biopsy / Q000379:methods; D018893:Bronchoalveolar Lavage / Q000379:methods; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D001999:Bronchoscopy / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D012680:Sensitivity and Specificity
keywords: Bronchoalveolar lavage; Bronchofiberoscopy; Cancer cells; Endobronchial brushing; Lung cancer; Squamous cell carcinoma; Tissue biopsy