title: Protein Turnover Provides Pancreatic Cancer Target.
abstract: Decreased activity of the chromatin remodeling factor geneSMARCB1drives a switch in pancreatic cancer cells toward a more aggressive, mesenchymal state. This change makes the tumors more susceptible to drugs that target protein metabolism and associated stress responses.
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics; D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000071796:SMARCB1 Protein / Q000235:genetics* / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D002843:Chromatin; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human