title: Efficient Enantioselective Syntheses of (+)-Dalesconol A and B.
abstract: We herein report the first enantioselective syntheses of immunosuppressants (+)-dalesconol A and B in a highly efficient and concise manner, which features an efficient palladium-catalyzed enantioselective dearomative cyclization-kinetic resolution cascade to install the chiral all-carbon quaternary center, an effective sterically hindered Stille coupling, a powerful 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) oxidation to furnish all requisite unsaturation, and a tandem hydrolysis-ring closure sequence.
authors.affiliation: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Ling Ling Road, Shanghai 200032, China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Ling Ling Road, Shanghai 200032, China.
authors.forename: Guangqing
authors.initials: G
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Ling Ling Road, Shanghai 200032, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Qian
authors.affiliation: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Ling Ling Road, Shanghai 200032, China.
authors.forename: Wenjun
authors.identifier: 0000-0002-8209-4156
authors.initials: W
authors.lastname: Tang
mesh_terms: D003500:Cyclization; D007700:Kinetics; D015394:Molecular Structure; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; C552720:dalesconol A; C552721:dalesconol B