title: Comparison of Carotid-Femoral and Brachial-Ankle Pulse-Wave Velocity in Association With Target Organ Damage in the Community-Dwelling Elderly Chinese: The Northern Shanghai Study.
abstract: Carotid-femoral pulse-wave velocity (cf-PWV) and brachial-ankle PWV (ba-PWV) are the 2 most frequently applied PWV measurements. However, little is known about the comparison of hypertensive target organ damage (TOD) with cf-PWV and ba-PWV.
  
  
  
  A total of 1599 community-dwelling elderly subjects (age >65 years) in northern Shanghai were recruited from June 2014 to August 2015. Both cf-PWV and ba-PWV were measured using SphygmoCor and VP1000 systems, respectively. Within the framework of comprehensive cardiovascular examinations, risk factors were assessed, and asymptomatic TOD, including left ventricular mass index, peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity (E/Ea), carotid intima-media thickness, arterial plaque, creatinine clearance rate, and urinary albumin-creatinine ratio were all evaluated. Both PWVs were significantly associated with male sex, age, waist/hip circumference, fasting plasma glucose, and systolic blood pressure, and ba-PWV was also significantly related to body mass index. Both PWVs were significantly correlated with most TOD. When cf-PWV and ba-PWV were both or separately put into the stepwise linear regression model together with cardiovascular risk factors and treatment, only cf-PWV, but not ba-PWV, was significantly associated with carotid intima-media thickness and creatinine clearance rate (P<0.05). When cf-PWV and ba-PWV were both or separately put into the same full-mode model after adjustment for confounders, only cf-PWV, but not ba-PWV, showed significant association with carotid intima-media thickness and creatinine clearance rate (P<0.05). Similar results were observed in logistic regression analysis.
  
  
  
  Taken together, in the community-dwelling elderly Chinese, cf-PWV seems to be more closely associated with hypertensive TOD, especially vascular and renal TOD, as compared with ba-PWV.
  
  
  
  URL: http://www.clinicaltrials.gov. Unique identifier: NCT02368938.
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Mengyun
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Bai
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chi
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Shikai
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Jiadela
authors.initials: J
authors.lastname: Teliewubai
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Henry
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xiong
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Yiwu
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Ji
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Ximin
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Xuejing
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Prevention, Tongji University School of Medicine, Shanghai, China.|Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, Shanghai, China.
authors.forename: Jue
authors.initials: J
authors.lastname: Li
authors.affiliation: Diagnosis and Therapeutic Center, Hôtel-Dieu, AP-HP, Paris Descartes University, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Blacher
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China yizshcn@gmail.com xuyawei@tongji.edu.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China yizshcn@gmail.com xuyawei@tongji.edu.cn.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index / Q000379:methods*; D001794:Blood Pressure / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D057187:Independent Living / Q000706:statistics & numerical data*; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D011673:Pulsatile Flow / Q000502:physiology*; D063177:Pulse Wave Analysis / Q000379:methods*; D012307:Risk Factors
keywords: brachial‐ankle pulse‐wave velocity; cardiovascular disease risk factors; carotid‐femoral pulse‐wave velocity; target organ damage