title: The development and characterization of a novel yet simple 3D printed tool to facilitate phantom imaging of photoacoustic contrast agents.
abstract: We report a new approach to preparing phantoms using 3D printing. This device supports plastic tubing containing the contrast agent and is immersed in a solution with absorption or scattering properties that mimic tissue. Up to 12 tubing samples could be placed in the device with sample-to-sample spacing as low as 0.3 mm and at a constant distance from the transducer (±0.16 mm), which is critical in validating photoacoustic contrast agents. We also studied different types of tubing and found that tubing with a larger outside diameter has more inherent signal. Both 40% India Ink and lipids in the immersion media modulated the signal. Finally, we created a depth phantom and found that signal decayed following a linear relationship (R2= 0.997) with respect to distance from the focal point. We include computer-assisted drafting code the community can use to print this phantom or customized versions of this phantom.
authors.affiliation: Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92092, USA.
authors.forename: Santiago J
authors.initials: SJ
authors.lastname: Arconada-Alvarez
authors.affiliation: Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92092, USA.
authors.forename: Jeanne E
authors.initials: JE
authors.lastname: Lemaster
authors.affiliation: Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92092, USA.
authors.forename: Junxin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92092, USA.
authors.forename: Jesse V
authors.initials: JV
authors.lastname: Jokerst
keywords: 3D printing; Optoacoustic imaging; Phantom; Photoacoustic imaging