title: Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-Related Macular Degeneration.
abstract: Purpose.To compare serum levels of malondialdehyde (MDA) in patients with wet age-related macular degeneration (wAMD), patients with dry AMD (dAMD), and patients without AMD and to evaluate the efficacy of nutritional supplementation for treating elevated serum MDA in patients with wAMD.Methods.MDA levels were measured in sera from 20 patients with wAMD, 20 with dAMD, and 24 without AMD. Patients with wAMD were randomized to receive or not receive nutritional supplementation (10 patients in each group), and MDA levels were measured after 3 months of treatment.Results.MDA levels in patients with wAMD were significantly greater compared with patients without AMD. In eyes with wAMD, there was a significant correlation between MDA levels and choroidal neovascularization lesion area. Serum MDA levels decreased in most patients that received supplementation and significantly increased in those who did not.Conclusion.Baseline serum MDA levels were elevated in patients with wAMD, and MDA levels were directly correlated with choroidal neovascularization lesion area. In addition, nutritional supplementation appeared to exert a protective effect against oxidative stress in patients with wAMD.
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Toshiyuki
authors.identifier: 0000-0003-1803-835X
authors.initials: T
authors.lastname: Matsuura
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Kei
authors.identifier: 0000-0002-1477-9014
authors.initials: K
authors.lastname: Takayama
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Hiroki
authors.identifier: 0000-0003-0731-6465
authors.initials: H
authors.lastname: Kaneko
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan; Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
authors.forename: Fuxiang
authors.identifier: 0000-0003-2550-2173
authors.initials: F
authors.lastname: Ye
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukukita
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Tsunekawa
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Kataoka
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan; Laboratory of Bell Research Center-Department of Obstetrics and Gynecology Collaborative Research, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Shiang-Jyi
authors.initials: SJ
authors.lastname: Hwang
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nagasaka
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Ito
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Terasaki
mesh_terms: D000368:Aged; D020256:Choroidal Neovascularization / Q000097:blood / Q000178:diet therapy* / Q000473:pathology; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000097:blood / Q000178:diet therapy* / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D057135:Wet Macular Degeneration / Q000097:blood / Q000178:diet therapy* / Q000473:pathology
chemical_list: D008315:Malondialdehyde