title: Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment.
abstract: Most cognitive functions decline with age. Prior studies suggest that testosterone treatment may improve these functions.
  
  
  
  To determine if testosterone treatment compared with placebo is associated with improved verbal memory and other cognitive functions in older men with low testosterone and age-associated memory impairment (AAMI).
  
  
  
  The Testosterone Trials (TTrials) were 7 trials to assess the efficacy of testosterone treatment in older men with low testosterone levels. The Cognitive Function Trial evaluated cognitive function in all TTrials participants. In 12 US academic medical centers, 788 men who were 65 years or older with a serum testosterone level less than 275 ng/mL and impaired sexual function, physical function, or vitality were allocated to testosterone treatment (n = 394) or placebo (n = 394). A subgroup of 493 men met criteria for AAMI based on baseline subjective memory complaints and objective memory performance. Enrollment in the TTrials began June 24, 2010; the final participant completed treatment and assessment in June 2014.
  
  
  
  Testosterone gel (adjusted to maintain the testosterone level within the normal range for young men) or placebo gel for 1 year.
  
  
  
  The primary outcome was the mean change from baseline to 6 months and 12 months for delayed paragraph recall (score range, 0 to 50) among men with AAMI. Secondary outcomes were mean changes in visual memory (Benton Visual Retention Test; score range, 0 to -26), executive function (Trail-Making Test B minus A; range, -290 to 290), and spatial ability (Card Rotation Test; score range, -80 to 80) among men with AAMI. Tests were administered at baseline, 6 months, and 12 months.
  
  
  
  Among the 493 men with AAMI (mean age, 72.3 years [SD, 5.8]; mean baseline testosterone, 234 ng/dL [SD, 65.1]), 247 were assigned to receive testosterone and 246 to receive placebo. Of these groups, 247 men in the testosterone group and 245 men in the placebo completed the memory study. There was no significant mean change from baseline to 6 and 12 months in delayed paragraph recall score among men with AAMI in the testosterone and placebo groups (adjusted estimated difference, -0.07 [95% CI, -0.92 to 0.79]; P = .88). Mean scores for delayed paragraph recall were 14.0 at baseline, 16.0 at 6 months, and 16.2 at 12 months in the testosterone group and 14.4 at baseline, 16.0 at 6 months, and 16.5 at 12 months in the placebo group. Testosterone was also not associated with significant differences in visual memory (-0.28 [95% CI, -0.76 to 0.19]; P = .24), executive function (-5.51 [95% CI, -12.91 to 1.88]; P = .14), or spatial ability (-0.12 [95% CI, -1.89 to 1.65]; P = .89).
  
  
  
  Among older men with low testosterone and age-associated memory impairment, treatment with testosterone for 1 year compared with placebo was not associated with improved memory or other cognitive functions.
  
  
  
  clinicaltrials.gov Identifier: NCT00799617.
authors.affiliation: Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Resnick
authors.affiliation: Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Puget Sound Health Care System, Seattle, Washington3Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, University of Washington School of Medicine, Seattle.
authors.forename: Alvin M
authors.initials: AM
authors.lastname: Matsumoto
authors.affiliation: Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia.
authors.forename: Alisa J
authors.initials: AJ
authors.lastname: Stephens-Shields
authors.affiliation: Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia.
authors.forename: Susan S
authors.initials: SS
authors.lastname: Ellenberg
authors.affiliation: Division of Geriatric Medicine, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Gill
authors.affiliation: Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors.forename: Sally A
authors.initials: SA
authors.lastname: Shumaker
authors.affiliation: Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors.forename: Debbie D
authors.initials: DD
authors.lastname: Pleasants
authors.affiliation: Department of Internal Medicine and Division of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego School of Medicine, La Jolla.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Barrett-Connor
authors.affiliation: Research Program in Men's Health, Aging, and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Shalender
authors.initials: S
authors.lastname: Bhasin
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Jane A
authors.initials: JA
authors.lastname: Cauley
authors.affiliation: Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: David
authors.initials: D
authors.lastname: Cella
authors.affiliation: Divisions of Endocrinology and Geriatrics, Albert Einstein College of Medicine, Bronx, New York.
authors.forename: Jill P
authors.initials: JP
authors.lastname: Crandall
authors.affiliation: Departments of Medicine and Molecular and Cellular Biology, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, Texas13Baylor St Luke's Medical Center, Houston, Texas14Department of Medicine, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis.
authors.forename: Glenn R
authors.initials: GR
authors.lastname: Cunningham
authors.affiliation: Department of Medicine, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis15Minneapolis Veterans Affairs Health Care System. Minneapolis, Minnesota.
authors.forename: Kristine E
authors.initials: KE
authors.lastname: Ensrud
authors.affiliation: Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia.
authors.forename: John T
authors.initials: JT
authors.lastname: Farrar
authors.affiliation: Division of Preventive Medicine, University of Alabama at Birmingham.
authors.forename: Cora E
authors.initials: CE
authors.lastname: Lewis
authors.affiliation: Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Molitch
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville.
authors.forename: Marco
authors.initials: M
authors.lastname: Pahor
authors.affiliation: Division of Endocrinology, Harbor-University of California at Los Angeles Medical Center, Torrance21Los Angeles Biomedical Research Institute, Torrance, California.
authors.forename: Ronald S
authors.initials: RS
authors.lastname: Swerdloff
authors.affiliation: Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia.
authors.forename: Denise
authors.initials: D
authors.lastname: Cifelli
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville.
authors.forename: Stephen
authors.initials: S
authors.lastname: Anton
authors.affiliation: Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors.forename: Shehzad
authors.initials: S
authors.lastname: Basaria
authors.affiliation: Department of Medicine, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Diem
authors.affiliation: Division of Endocrinology, Harbor-University of California at Los Angeles Medical Center, Torrance21Los Angeles Biomedical Research Institute, Torrance, California.
authors.forename: Christina
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Hou
authors.affiliation: Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Snyder
mesh_terms: D000368:Aged; D000728:Androgens / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects / Q000502:physiology; D004311:Double-Blind Method; D056344:Executive Function / Q000187:drug effects / Q000502:physiology; D005782:Gels; D006801:Humans; D057194:Intention to Treat Analysis; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D008569:Memory Disorders / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology; D012016:Reference Values; D013739:Testosterone / Q000097:blood / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000728:Androgens; D005782:Gels; D013739:Testosterone