title: p53 switches off pluripotency on differentiation.
abstract: The role of p53 as "a guardian of the genome" has been well established in somatic cells. However, its role in pluripotent stem cells remains much more elusive. Here, we discuss research progress in understanding the role of p53 in pluripotent stem cells and in pluripotent stem cell-like cancer stem cells. The p53 protein, which plays a key role in embryonic stem cells, was first discovered in 2005. Landmark studies of p53-related reprogramming elucidated this protein's importance in induced pluripotent stem cells in 2009. The p53-related safety concerns in pluripotent stem cells have been raised in stem cell-based therapy although the use of iPSCs in therapeutic application is promising. Because cancer stem cells have profiles similar to those of pluripotent stem cells, we also describe potential strategies for studies in cancer stem cells and cancer treatments. The new discoveries of p53 family proteins in pluripotent stem cells have made possible stable progress in stem cell transplantation efficiency and safety, as well as treatment strategies targeting cancer stem cells based on pluripotent stem cell technology.
authors.affiliation: Stem Cell Research Center, College of Bee Science, Fujian Agriculture and Forestry University, 15 ShangXiaDian Rd, Fuzhou, Fujian, 350002, China. lintx69@163.com.|Center for Regenerative and Translational Medicine, The Second Affiliated Hospital (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou University of Chinese Medicine, 111 Dade Rd, Guangzhou, Guangdong, 510120, China. lintx69@163.com.
authors.forename: Tongxiang
authors.identifier: 0000-0001-7033-6982
authors.initials: T
authors.lastname: Lin
authors.affiliation: Stem Cell Research Center, College of Bee Science, Fujian Agriculture and Forestry University, 15 ShangXiaDian Rd, Fuzhou, Fujian, 350002, China. lin_yi_1@yahoo.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D064987:Cell- and Tissue-Based Therapy; D053595:Embryonic Stem Cells; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D014411:Neoplastic Stem Cells; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism*; D015398:Signal Transduction; D033581:Stem Cell Transplantation; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53
keywords: Cancer stem cells; Embryonic stem cells (ESCs); Induced pluripotent stem cells (iPSCs); P53