title: Increased Local Sympathetic Nerve Activity During Pathogenesis of Ventricular Arrhythmias Originating from the Right Ventricular Outflow Tract.
abstract: BACKGROUND The contribution of local sympathetic nerves to ventricular arrhythmia (VA) originating from the right ventricular outflow tract (RVOT) has not been elucidated. This study used a canine model to investigate the anatomical changes of the RVOT associated with VA, and the distribution of local sympathetic nerves. MATERIAL AND METHODS The RVOT-VA canine model (6 dogs) was induced with a circular catheter and high-frequency stimulation (100 Hz) in the middle of the pulmonary artery trunk. Six dogs who were not given stimulation served as the control group. The serum levels of neurotransmitters, the extent of myocardial extension, and the sympathetic nerve density of the RVOT were also analyzed. RESULTS Ventricular arrhythmias, including premature ventricular contractions, were induced in the experimental group after high-frequency stimulation. Dogs from the RVOT-VA group showed enhanced myocardial extension and sympathetic nerve density in the septal wall as compared with those of the free wall of the RVOT. In the RVOT-VA dogs, serum norepinephrine and neuropeptide Y and the sympathetic nerve density were significantly higher compared with the control group. CONCLUSIONS Stimulation of the pulmonary artery could activate local sympathetic nerves and enhance myocardial extension, which may be the foundation of RVOT-VA. The RVOT voltage transitional zone positively correlated with myocardial extension, which may serve as an important target for the radiofrequency catheter ablation of RVOT-VA clinically.
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Zefeng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Huikuan
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Ruiqing
authors.initials: R
authors.lastname: Dong
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Can
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Tianyu
authors.initials: T
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Hui
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D053840:Brugada Syndrome / Q000503:physiopathology; D000075224:Cardiac Conduction System Disease; D017115:Catheter Ablation / Q000379:methods; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D006352:Heart Ventricles / Q000294:innervation / Q000503:physiopathology; D011651:Pulmonary Artery / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D017180:Tachycardia, Ventricular / Q000503:physiopathology; D014694:Ventricular Outflow Obstruction / Q000503:physiopathology*