title: Effect of a polysaccharide-rich hydrolysate from Saccharomyces cerevisiae (LipiGo®) in body weight loss: randomised, double-blind, placebo-controlled clinical trial in overweight and obese adults.
abstract: BACKGROUND
  In the present study we evaluated the weight loss effect of a polysaccharide-rich food supplement, LipiGo®, comprising a specific β-glucan-chitin-chitosan fraction (BGCC) obtained from the chemical hydrolysis of Saccharomyces cerevisiae, resulting as a by-product of the brewing process.
  
  
  RESULTS
  A randomised, double-blind, placebo-controlled clinical trial was performed enrolling 56 overweight and obese subjects (body mass index, BMI, 25-35 kg m-2) who were not following any specific diet, and were given placebo or BGCC (3 g d-1) for 12 weeks. Results were analysed by intention-to-treat (ITT) and per-protocol (PP) methods. Body weight increased in the placebo group compared to baseline (ITT: 1.0 kg, P < 0.001; PP: 1.5 kg, P = 0.003), while it was slightly lowered in the BGCC group (ITT: -0.8 kg, P = 0.210; PP: -1.1 kg, P = 0.182). BGCC, but not the consumption of placebo, also resulted in a reduction of waist circumference and body fat compared to baseline.
  
  
  CONCLUSIONS
  Results suggest that daily supplementation of BGCC may be useful for improving body weight and waist circumference in overweight and obese subjects, without relevant adverse effects. © 2017 Society of Chemical Industry.
authors.affiliation: AB-Biotics, Sant Cugat del Vallès, Barcelona, Spain.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Santas
authors.affiliation: AB-Biotics, Sant Cugat del Vallès, Barcelona, Spain.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Lázaro
authors.affiliation: AB-Biotics, Sant Cugat del Vallès, Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Cuñé
mesh_terms: D000328:Adult; D000368:Aged; D019440:Anti-Obesity Agents / Q000008:administration & dosage* / Q000378:metabolism; D015992:Body Mass Index; D019587:Dietary Supplements / Q000032:analysis; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D050177:Overweight / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D011134:Polysaccharides / Q000008:administration & dosage* / Q000737:chemistry; D011446:Prospective Studies; D012441:Saccharomyces cerevisiae / Q000737:chemistry*; D014866:Waste Products / Q000032:analysis; D015431:Weight Loss / Q000187:drug effects; D055815:Young Adult
chemical_list: D019440:Anti-Obesity Agents; D011134:Polysaccharides; D014866:Waste Products
keywords: Saccharomyces cerevisiae; body weight; chitosan; obesity; β-glucan