title: Biomarkers in Allergic Airway Disease: Simply Complex.
abstract: Clinical diagnoses of allergic airway disease need confirmation of a relevant sensitization to allergens. Serum-based component-resolved diagnosis has become increasingly popular and allows the precise assessment of specific IgE to molecular allergens. Molecular allergen diagnosis has improved our understanding of disease phenotypes in allergic patients, including cross-reactive patterns and food allergy. Beyond sensitization profiles, characterization of the (endo-)type and severity of a local allergic disease is useful for targeted therapy with biologics in advanced allergic airway disease. Surrogate markers of treatment efficacy are increasingly under validation. Prognostic and predictive biomarkers will represent a promising option for stratified prevention strategies.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Medical School, Technical University of Munich, Munich, Germany.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Chaker
authors.forename: Ulrich M
authors.initials: UM
authors.lastname: Zissler
authors.forename: Martin
authors.initials: M
authors.lastname: Wagenmann
authors.forename: Carsten
authors.initials: C
authors.lastname: Schmidt-Weber
mesh_terms: D000485:Allergens / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D011379:Prognosis; D012130:Respiratory Hypersensitivity / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D018570:Risk Assessment
chemical_list: D000485:Allergens; D015415:Biomarkers