title: Picking the Survivor! CRISPR Reveals HIV Dependency Factors.
abstract: A new study employs genome-wide loss-of-function CRISPR/Cas9 screening to identify three novel factors for HIV-1 entry. The factors represent promising targets for therapeutics as they are essential for HIV-1 infection, but dispensable for cell survival. The involved pathways were validated in primary CD4+T cells, target cells for HIV-1.
authors.affiliation: Host-Pathogen Interactions, Paul-Ehrlich-Institut, 63225 Langen, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Schott
authors.affiliation: Host-Pathogen Interactions, Paul-Ehrlich-Institut, 63225 Langen, Germany; Immunity and Pathogenesis Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; German Center for Infection Research (DZIF), 63225 Langen, Germany. Electronic address: Renate.Koenig@pei.de.
authors.forename: Renate
authors.initials: R
authors.lastname: König
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D064113:CRISPR-Cas Systems / Q000235:genetics*; D064112:Clustered Regularly Interspaced Short Palindromic Repeats / Q000235:genetics*; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000254:growth & development*; D058605:Host-Derived Cellular Factors / Q000235:genetics*; D006801:Humans; D053586:Virus Internalization; D014779:Virus Replication / Q000235:genetics*
chemical_list: D058605:Host-Derived Cellular Factors
keywords: CRISPR/Cas9 screening; HIV-1; dependency factors