title: Disaggregation of human islet amyloid polypeptide fibril formation by ruthenium polypyridyl complexes.
abstract: The toxicity of amyloid proteins is associated with many degenerative and systematic diseases. The aggregation of human islet amyloid polypeptide may induce pancreatic β-cell death, which is linked to type II diabetes. Ruthenium complexes are inhibitors of various proteins and potential anticancer metallodrugs, which can also be used to disaggregate amyloid proteins. This work reported that several ruthenium polypyridyl complexes remarkably affected the peptide aggregation by predominant hydrophobic interaction and metal coordination, as reflected by thermodynamic parameters and mass spectrometry analysis. Morphology and particle size analysis showed that the amyloid fibrils were disaggregated from long fibrils into small nano particles. Addition of these complexes also decreased the cytotoxicity induced by the peptide. The results indicated that ruthenium polypyridyl complexes may be potential metallodrugs to treat amyloidosis.
authors.affiliation: Department of Chemistry, Renmin University of China, Beijing, China.
authors.forename: Dengsen
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Department of Chemistry, Renmin University of China, Beijing, China.
authors.forename: Gehui
authors.initials: G
authors.lastname: Gong
authors.affiliation: Department of Chemistry, Renmin University of China, Beijing, China.
authors.forename: Wenji
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Renmin University of China, Beijing, China. Electronic address: whdu@ruc.edu.cn.
authors.forename: Weihong
authors.initials: W
authors.lastname: Du
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D006801:Humans; D058228:Islet Amyloid Polypeptide / Q000737:chemistry*; D066329:Protein Aggregates; D011725:Pyridines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D058228:Islet Amyloid Polypeptide; D066329:Protein Aggregates; D011725:Pyridines; D012428:Ruthenium
keywords: Disaggregation; Interaction; Ru polypyridyl complex; hIAPP