title: Facile synthesis and application of teicoplanin-modified magnetic microparticles for enantioseparation.
abstract: A facile, mild method for the preparation of teicoplanin (TE) modified Fe3O4microparticles (MPs) employing polydopamine (PDA) layer as a versatile secondary reaction platform was developed. The synthesized magnetic MPs (Fe3O4@PDA@TE) were characterized by various characterization techniques, such as TEM, zeta potential etc, to affirm the successful modification of TE to magnetic Fe3O4MPs. Using the as-synthesized materials as chiral adsorbents, efficient chiral separation of representative racemic compounds was successfully achieved. Due to the magnetic responsivity, the materials were easily isolated from the racemic solutions under an external magnetic field and could be readily reused for at least three times. Thus, the well-prepared functional magnetic MPs have great potential in preparative chiral separation.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P.R. China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P.R. China.
authors.forename: Xuehan
authors.initials: X
authors.lastname: An
authors.affiliation: Analysis Center, Tianjin University, Tianjin, P.R. China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Deng
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P.R. China.|Analysis Center, Tianjin University, Tianjin, P.R. China.|State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin, P.R. China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Ding
mesh_terms: D000327:Adsorption; D019075:Electrophoresis, Capillary / Q000379:methods*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D008863:Microspheres; D011108:Polymers / Q000737:chemistry*; D013237:Stereoisomerism; D017334:Teicoplanin / Q000737:chemistry*
chemical_list: D007211:Indoles; D011108:Polymers; C568283:polydopamine; D017334:Teicoplanin; D052203:Ferrosoferric Oxide
keywords: Chiral separation; Magnetic microparticles; Polydopamine; Teicoplanin