title: Electromyography-guided hyaluronic acid injection laryngoplasty in early stage of unilateral vocal fold paralysis.
abstract: OBJECTIVE
  To assess the effectiveness of electromyography-guided hyaluronic acid injection laryngoplasty in the early stage of unilateral vocal fold paralysis in terms of patient recovery from dysphonia and quality of life.
  
  
  METHODS
  Between January and December 2014, 28 patients with unilateral vocal fold paralysis underwent electromyography and injection of hyaluronic acid in the thyroarytenoid muscle. We compared the voice handicap index, grade, roughness, breathiness, asthenia, strain scale (GRBAS), videostroboscopic parameters and maximum phonation time assessed before, 15 days and 6 months after the intervention, using the non-parametric Wilcoxon rank test.
  
  
  RESULTS
  Out of the 28 patients, 1 had a haematoma in the injected vocal fold (3.57%) and 6 required second injections. The maximum phonation time of the vowel /e/ increased from 6.07 to 12.14 sec. (15 days post-intervention) and subsequently 12.75 (6 months post-intervention). There was also a significant improvement in the grade, roughness, breathiness, asthenia, strain scale in parameters G, B and A both 15 days and 6 months after the intervention. The voice handicap index score decreased from 58.29 to 37.63 (15 days post-intervention) and 29.64 (6 months post-intervention).
  
  
  CONCLUSIONS
  Electromyography-guided hyaluronic injection laryngoplasty in unilateral vocal fold paralysis enables, in the same intervention, neuromuscular assessment and temporary treatment of glottic insufficiency with a low risk of complications and improvement in patient's quality of life. This may reduce the need for subsequent treatments, but further research is required to confirm these findings.
authors.affiliation: Servicio de Otorrinolaringología, Hospital Galdakao-Usansolo, Vizcaya, España. Electronic address: i.gotxierezuma@gmail.com.
authors.forename: Itziar
authors.initials: I
authors.lastname: Gotxi-Erezuma
authors.affiliation: Servicio de Neurofisiología Clínica, Hospital Galdakao-Usansolo, Vizcaya, España.
authors.forename: Mónica
authors.initials: M
authors.lastname: Ortega-Galán
authors.affiliation: Servicio de Otorrinolaringología, Hospital Galdakao-Usansolo, Vizcaya, España.
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Laso-Elguezabal
authors.affiliation: Servicio de Otorrinolaringología, Hospital Galdakao-Usansolo, Vizcaya, España.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Prieto Puga
authors.affiliation: Servicio de Otorrinolaringología, Hospital Galdakao-Usansolo, Vizcaya, España.
authors.forename: Carolina
authors.initials: C
authors.lastname: Bullido-Alonso
authors.affiliation: Unidad de Investigación, Hospital Galdakao-Usansolo, Vizcaya, España; REDISSEC- Red de Investigación en Servicios de Salud en Enfermedades Crónicas, España.
authors.forename: Susana
authors.initials: S
authors.lastname: García-Gutiérrez
authors.affiliation: Unidad de Investigación, Hospital Galdakao-Usansolo, Vizcaya, España.
authors.forename: Ane
authors.initials: A
authors.lastname: Anton-Ladislao
authors.affiliation: Servicio de Otorrinolaringología, Hospital Galdakao-Usansolo, Vizcaya, España.
authors.forename: Enrique
authors.initials: E
authors.lastname: Moreno-Alonso
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004576:Electromyography; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007267:Injections; D058753:Laryngoplasty / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014826:Vocal Cord Paralysis / Q000628:therapy*
chemical_list: D006820:Hyaluronic Acid
keywords: Electromiografía; Electromyography; Hyaluronic acid; Laringología; Laringoplastia; Laryngology; Laryngoplasty; Parálisis unilateral de cuerda vocal; Unilateral vocal cold paralysis; Ácido hialurónico