title: The protective effects of resveratrol, H2S and thermotherapy on the cell apoptosis induced by CdTe quantum dots.
abstract: Quantum dots (QDs) could be used in the field of biology and medicine as excellent nano-scale fluorescent probes due to their unique optical properties, but the adverse effects of QDs are always the obstruction for its usage in living organisms. In this study, we observed that CdTe QDs exposure decreased the cell viability while increased the apoptosis rates in the L929 cells. Apart from QD-induced oxidative stress indicated by excessive ROS generation, three signal transductions, including Akt, p38 and JNK, played important roles on the regulation of cell apoptosis by CdTe QDs exposure as well. In order to reduce the toxicity of CdTe QDs, we explored the protective effects of three treatments, i.e. resveratrol, H2S and thermotherapy at 43°C, against the cell apoptosis elicited by CdTe QDs. The results showed that resveratrol, H2S and thermotherapy at 43°C were capable of attenuating cell apoptosis and intercellular ROS production through inhibiting signal pathways of Akt, p38 and JNK, respectively. As there is only limited number of exogenous treatments reported to diminish the toxicity of QDs, our findings will provide a novel insight for researchers who try to reduce or even eliminate the adverse health effects of QDs.
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
authors.forename: Tianshu
authors.initials: T
authors.lastname: Wu
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
authors.forename: Qingling
authors.initials: Q
authors.lastname: Zhan
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
authors.forename: Shengjun
authors.initials: S
authors.lastname: Ang
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Ying
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
authors.forename: Keyu
authors.initials: K
authors.lastname: He
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
authors.forename: Shihan
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China. Electronic address: tm@seu.edu.cn.
authors.forename: Meng
authors.initials: M
authors.lastname: Tang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D019187:Cadmium Compounds / Q000633:toxicity*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006862:Hydrogen Sulfide / Q000494:pharmacology*; D006979:Hyperthermia, Induced; D048670:MAP Kinase Kinase 4 / Q000378:metabolism; D051379:Mice; D020011:Protective Agents / Q000494:pharmacology*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D045663:Quantum Dots / Q000633:toxicity*; D017382:Reactive Oxygen Species / Q000378:metabolism; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology*; D013691:Tellurium / Q000633:toxicity*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D019187:Cadmium Compounds; D020011:Protective Agents; D017382:Reactive Oxygen Species; D013267:Stilbenes; D051057:Proto-Oncogene Proteins c-akt; D048051:p38 Mitogen-Activated Protein Kinases; D048670:MAP Kinase Kinase 4; D013691:Tellurium; D000077185:Resveratrol; C028337:cadmium telluride; D006862:Hydrogen Sulfide
keywords: Apoptosis; H(2)S; Quantum dots; ROS; Resveratrol; Thermotherapy