title: The microbial etiology and antimicrobial susceptibility of bloodstream infections in patients with cancer at a private tertiary care hospital in Mumbai, India.
abstract: BACKGROUND
  Knowledge of the etiology and antimicrobial susceptibility of blood stream infections in patients with cancer is crucial to design empirical therapy regimes.
  
  
  METHODS
  This is a prospective observational study at a tertiary care private hospital in Mumbai, India from Nov 2009 - Dec 2014.
  
  
  RESULTS
  A total of 62 episodes of blood stream infections in 57 patients with cancer were recorded during the study period. Analysis was limited to 52 isolates from 49 episodes in 45 patients. Gram negative pathogens caused 77% of these infections; commonest pathogens were E. coli and Klebsiella. High prevalence of antimicrobial resistance was noted. Susceptibility in E. coli, Klebsiella, Acinetobacter and Pseudomonas to 3rd generation cephalosporins, beta lactam beta lactamase inhibitor combinations, carbapenems and amikacin was 4%, 56.5%, 70% and 86% respectively.
  
  
  CONCLUSIONS
  The high rates of antimicrobial resistance in gram negative isolates is alarming.
authors.affiliation: Department of Infection Prevention and Control, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, Maharashtra, India.
authors.forename: T
authors.initials: T
authors.lastname: Singhal
authors.affiliation: Department of Infection Prevention and Control, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, Maharashtra, India.
authors.forename: S
authors.initials: S
authors.lastname: Shah
authors.affiliation: Department of Infection Prevention and Control, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, Maharashtra, India.
authors.forename: R
authors.initials: R
authors.lastname: Naik
mesh_terms: D000150:Acinetobacter / Q000187:drug effects / Q000302:isolation & purification; D000890:Anti-Infective Agents / Q000494:pharmacology; D016470:Bacteremia / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D015331:Cohort Studies; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007709:Klebsiella / Q000187:drug effects / Q000302:isolation & purification; D008297:Male; D008826:Microbial Sensitivity Tests; D009369:Neoplasms / Q000453:epidemiology / Q000382:microbiology*; D011446:Prospective Studies; D011549:Pseudomonas / Q000187:drug effects / Q000302:isolation & purification; D062606:Tertiary Care Centers
chemical_list: D000890:Anti-Infective Agents