title: Effects of Roux-en-Y gastric bypass on insulin secretion and sensitivity, glucose homeostasis, and diabetic control: A prospective cohort study in Chinese patients.
abstract: To report on the effects of Roux-en-Y gastric bypass operation for obesity on measures of adiposity, insulin secretion and sensitivity, glucose homeostasis, and improvement in diabetic control in Chinese patients.
  
  
  
  This was a prospective cohort study of 152 participants (81% with diabetes) who were recruited for bariatric operation.
  
  
  
  Mean body mass index was decreased by 18.1% from 30.31 ± 5.38 kg/m2at baseline to 24.45 ± 3.79 kg/m2at 2 years (P < .001). Indices of insulin secretion, including serum c-peptide (both fasted and at various time points during an oral glucose tolerance test) improved at the 3-year follow-up, with a significant improvement in insulin sensitivity and glucose homeostasis.
  
  
  
  The effects of Roux-en-Y gastric bypass 3 years postoperative on adiposity were paralleled by a significant improvement in insulin secretion and sensitivity, and glucose tolerance.
authors.affiliation: Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing, China; Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science (IC-UCAS), Chaoyang, China. Electronic address: moshen@genetics.ac.cn.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Mazidi
authors.affiliation: Department of General Surgery, the General Hospital of Chinese People's Armed Police Forces, Beijing, China.
authors.forename: Hong-Kai
authors.initials: HK
authors.lastname: Gao
authors.affiliation: Department of General Surgery, the General Hospital of Chinese People's Armed Police Forces, Beijing, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of General Surgery, the General Hospital of Chinese People's Armed Police Forces, Beijing, China.
authors.forename: Han
authors.initials: H
authors.lastname: Hui
authors.affiliation: Department of General Surgery, the General Hospital of Chinese People's Armed Police Forces, Beijing, China.
authors.lastname: Zhang Ye
mesh_terms: D050154:Adiposity; D044466:Asian People; D001786:Blood Glucose; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000208:ethnology / Q000378:metabolism* / Q000601:surgery*; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose