title: Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome.
abstract: Electric conductivity in plasma is the balance between oxidized and reduced molecules (static Oxidation-Reduction Potential, sORP) and the amount of readily oxidizable molecules (capacity ORP, cORP). Adults with metabolic syndrome (MetS) have increased inflammation, dyslipidemia and oxidative stress; therefore, participants with MetS were hypothesized to have higher plasma sORP and lower cORP than those measures in healthy adults. Heparin-anticoagulated plasma from healthy and age- and gender-matched individuals with MetS (BMI: 22.6±0.7 vs. 37.7±3.0kg/m2, respectively) was collected in the fasting state at 0, 24, 48, and 72h during each of four separate interventions in a clinical trial. At baseline, plasma sORP was 12.4% higher (P=0.007), while cORP values were less than half (41.1%, P=0.001) in those with MetS compared with healthy participants. An sORP >140mV detected MetS with 90% sensitivity and 80% specificity, while a cORP <0.50μC detected MetS with 80% sensitivity and 100% specificity. sORP and cORP values in participants with MetS compared with healthy adults were linked to differences in waist circumference and BMI; in plasma markers of dyslipidemia (triglycerides, HDL-cholesterol, and oxidized LDL-cholesterol) and inflammation (C-reactive protein, IL-10); as well as with urinary markers of lipid peroxidation (e.g., 2,3-dinor-5,6-dihydro-8-iso-PGF2α; 2,3-dinor-8-iso-PGF2α). Higher sORP values are a robust indicator of metabolic stress, while lower cORP values act as an indicator of decreased metabolic resilience.
authors.affiliation: Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, United States.
authors.forename: Gerd
authors.initials: G
authors.lastname: Bobe
authors.affiliation: Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, United States.
authors.forename: Tora J
authors.initials: TJ
authors.lastname: Cobb
authors.affiliation: Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, United States.
authors.forename: Scott W
authors.initials: SW
authors.lastname: Leonard
authors.affiliation: Department of Chemistry, Oregon State University, Corvallis, OR 97331, United States.
authors.forename: Savinda
authors.initials: S
authors.lastname: Aponso
authors.affiliation: Department of Chemistry, Oregon State University, Corvallis, OR 97331, United States.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Bahro
authors.affiliation: Department of Chemistry, Oregon State University, Corvallis, OR 97331, United States.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Koley
authors.affiliation: Biofortis, Inc., Addison, IL, United States.
authors.forename: Eunice
authors.initials: E
authors.lastname: Mah
authors.affiliation: Human Nutrition Program, The Ohio State University, Columbus, OH 43210, United States.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Bruno
authors.affiliation: Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, United States. Electronic address: maret.traber@oregonstate.edu.
authors.forename: Maret G
authors.initials: MG
authors.lastname: Traber
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D010084:Oxidation-Reduction; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; C508609:IL10 protein, human; D008077:Lipoproteins, LDL; D014280:Triglycerides; D016753:Interleukin-10; D002097:C-Reactive Protein
keywords: Dyslipidemia; Inflammation; Isoprostanes; Lipid peroxidation; Metabolic syndrome; Obesity; Oxidation-reduction potential