title: Gastro-oesophageal reflux disease in 20 dogs (2012 to 2014).
abstract: OBJECTIVE
  To describe the clinical features of canine gastro-oesophageal reflux disease.
  
  
  METHODS
  A search of our medical records produced 20 dogs with clinical signs attributable to oesophageal disease, hyper-regeneratory oesophagopathy and no other oesophageal disorders. The clinical, endoscopic and histological findings of the dogs were analysed.
  
  
  RESULTS
  The 3-year incidence of gastro-oesophageal reflux disease was 0·9% of our referral dog population. Main clinical signs were regurgitation, discomfort or pain (each, 20/20 dogs) and ptyalism (18/20 dogs). Oesophagoscopy showed no (5/20 dogs) or minimal (13/20 dogs) mucosal lesions. In oesophageal mucosal biopsy specimens, there were hyperplastic changes of the basal cell layer (13/20 dogs), stromal papillae (14/20 dogs) and entire epithelium (9/20 dogs). Eleven dogs received omeprazole or pantoprazole and regurgitation and ptyalism improved in eight and pain diminished in six of these dogs within three to six weeks.
  
  
  CONCLUSIONS
  Our findings suggest that canine gastro-oesophageal reflux disease is a more common clinical problem than hitherto suspected.
authors.affiliation: Tieraerztliche Gemeinschaftspraxis Dr. Hoerauf & Dr. Muenster, Cologne 51069, Germany.
authors.forename: M
authors.identifier: http://orcid.org/0000-0001-7977-2625
authors.initials: M
authors.lastname: Muenster
authors.affiliation: Tieraerztliche Gemeinschaftspraxis Dr. Hoerauf & Dr. Muenster, Cologne 51069, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Hoerauf
authors.affiliation: Institute of Pathology, Klinikum Bayreuth GmbH, Bayreuth, 95445, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Vieth
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000453:epidemiology* / Q000473:pathology; D004285:Dogs; D004945:Esophagoscopy / Q000662:veterinary*; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use
chemical_list: D009853:Omeprazole