title: Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives.
abstract: Artemisinin and its derivatives have been reported to be experimentally effective for the treatment of highly aggressive cancers without developing drug resistance, they are useful for the treatment of malaria, other protozoal infections and they exhibit antiviral activity. However, they are limited pharmacologically by their poor bioavailability, short half-life in vivo, poor water solubility and long term usage results in toxicity. They are also expensive for the treatment of malaria when compared to other antimalarials. In order to enhance their therapeutic efficacy, they are incorporated onto different drug delivery systems, thus yielding improved biological outcomes. This review article is focused on the currently synthesized derivatives of artemisinin and different delivery systems used for the incorporation of artemisinin and its derivatives.
authors.affiliation: Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa. blessingaderibigbe@gmail.com.
authors.forename: Blessing Atim
authors.initials: BA
authors.lastname: Aderibigbe
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D037621:Artemisinins / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D004333:Drug Administration Routes; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004337:Drug Carriers
keywords: arteether; artemether; artemisinin; artesunate; drug delivery systems