title: Genetic Variants in the ELOVL5 but not ELOVL2 Gene Associated with Polyunsaturated Fatty Acids in Han Chinese Breast Milk.
abstract: The present study was designed to examine the contributions of the fatty acid elongase (ELOVL) gene polymorphisms to the levels of polyunsaturated fatty acids (PUFAs) in breast milk. Two hundred and nine healthy Han Chinese mothers were included in the study. Carriers of minor alleles of SNPs (rs2397142 and rs9357760) in ELOVL5 were associated with higher levels of linoleic acid (LA), dihomo-γ-linolenic acid (DGLA), arachidonic acid (AA), docosatetraenoic acid (DTA), docosahexenoic acid (DHA), while in rs209512 of ELOVL5 the carriers of minor alleles had lower levels of DTA compared to major homozygote alleles (P ranged from 0.004-0.046), and genetically explained variability ranged from 3.2% for eicosapentaenoic acid (EPA) to 6.0% for LA. Our findings demonstrated that common variation in ELOVL5 gene encoding rate-limiting enzymes in the metabolism of PUFAs contribute to the PUFAs in breast milk.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin, China; Jilin Provincial Cancer Hospital, Changchun 130012, Jilin, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Experimental Center of Prevention, School of Public Health, Jilin University, Changchun 130021, Jilin, China.
authors.forename: Zhen Wei
authors.initials: ZW
authors.lastname: Gan
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin, China.
authors.forename: Yi Xia
authors.initials: YX
authors.lastname: Wu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin, China.
authors.forename: Xue Yan
authors.initials: XY
authors.lastname: Chen
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin, China.
authors.forename: Hui Min
authors.initials: HM
authors.lastname: Tian
authors.affiliation: Experimental Center of Prevention, School of Public Health, Jilin University, Changchun 130021, Jilin, China.
authors.forename: Guo Liang
authors.initials: GL
authors.lastname: Liu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin, China.
authors.forename: Ye Tong
authors.initials: YT
authors.lastname: Yang
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xie
mesh_terms: D000123:Acetyltransferases / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002681:China; D000081031:Fatty Acid Elongases; D005231:Fatty Acids, Unsaturated / Q000235:genetics*; D005260:Female; D006801:Humans; D008895:Milk, Human / Q000737:chemistry*; D020641:Polymorphism, Single Nucleotide
chemical_list: C000630967:ELOVL2 protein, human; C000630954:ELOVL5 protein, human; D005231:Fatty Acids, Unsaturated; D000123:Acetyltransferases; D000081031:Fatty Acid Elongases