title: Sinusoidal endotheliitis as a histological parameter for diagnosing acute liver allograft rejection.
abstract: To investigated the feasibility of using sinusoidal endotheliitis (SE) as a histological marker for liver allograft rejection.
  
  
  
  We compared the histological features of 88 liver allograft biopsies with acute cellular rejection (ACR) and 59 cases with no evidence of ACR. SE was scored as: (1) focal linear lifting up of the endothelial cells by lymphocytes with no obvious damage to adjacent hepatocytes; (2) focal disruption of the endothelial lining by a cluster of subendothelial lymphocytes (a group of > 3 lymphocytes); and (3) severe confluent endotheliitis with hemorrhage and adjacent hepatocyte loss.
  
  
  
  The sensitivity and specificity of SE was 81% and 85%, respectively. Using SE as the only parameter, the positive predictive value for ACR (PPV) was 0.89, whereas the negative predictive value for ACR (NPV) was 0.75. The correlation between RAI and SE was moderate (R = 0.44,P< 0.001) (Figure 3A), whereas it became strong (R = 0.65,P< 0.001) when correlating SE with the venous endotheliitis activity index only.
  
  
  
  Our data suggest that SE scoring could be a reliable and reproducible supplemental parameter to the existing Banff schema for diagnosing acute liver allograft rejection.
authors.affiliation: Department of Pathology, McGill University, Montreal, Quebec QCH3A0G4, Canada.|Department of Laboratory Medicine, Dr. Everett Chalmers Regional Hospital, Horizon Health Network, Fredericton, New Brunswick E3B 5N5, Canada.
authors.forename: Yu
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Pathology, Beijing YouAn Hospital, Capital Medical University, Beijing 100054, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Dong
authors.affiliation: Department of Traditional and Western Medical Hepatology, The Third Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
authors.forename: Yu-Guo
authors.initials: YG
authors.lastname: Zhang
authors.affiliation: Department of Pathology, McGill University, Montreal, Quebec QCH3A0G4, Canada.
authors.forename: René P
authors.initials: RP
authors.lastname: Michel
authors.affiliation: Department of Pathology, McGill University, Montreal, Quebec QCH3A0G4, Canada.
authors.forename: Victoria
authors.initials: V
authors.lastname: Marcus
authors.affiliation: Department of Pathology, McGill University, Montreal, Quebec QCH3A0G4, Canada.
authors.forename: Yu-Yue
authors.initials: YY
authors.lastname: Wang
authors.affiliation: Department of Laboratory Medicine, Dr. Everett Chalmers Regional Hospital, Horizon Health Network, Fredericton, New Brunswick E3B 5N5, Canada.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pathology, McGill University, Montreal, Quebec QCH3A0G4, Canada.
authors.forename: Zu-Hua
authors.initials: ZH
authors.lastname: Gao
mesh_terms: D000208:Acute Disease; D064591:Allografts; D016022:Case-Control Studies; D004727:Endothelium / Q000473:pathology; D006084:Graft Rejection / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000473:pathology*; D016031:Liver Transplantation / Q000009:adverse effects*
keywords: Acute cellular rejection; Liver transplantation; Sinusoidal endotheliitis