title: Green Neutrophilic Inclusions and Acute Hepatic Failure: Clinical Significance and Brief Review of the Literature.
abstract: Medical literature has documented an association between acute hepatic failure and coarse, bright-green neutrophilic inclusions. Upon identification of these unique inclusions patients have been reported to have poor outcomes and usually die within 24-72 hours. The exact nature of these inclusions has yet to be determined; it is postulated that they arise from lipofusion-like substance. Here, we describe five cases of acute hepatic failure, with associated bright-green neutrophilic inclusions, where four patients survived beyond the ominous 72-hour window period.
authors.affiliation: Department of Clinical Pathology, Beaumont Health System, Royal Oak, Michigan, USA kristle.haberichter@beaumont.org.
authors.forename: Kristle L
authors.initials: KL
authors.lastname: Haberichter
authors.affiliation: Department of Clinical Pathology, Beaumont Health System, Royal Oak, Michigan, USA.
authors.forename: Domnita
authors.initials: D
authors.lastname: Crisan
mesh_terms: D000328:Adult; D000368:Aged; D003710:Demography; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology*; D008099:Liver / Q000473:pathology; D017114:Liver Failure, Acute / Q000473:pathology*; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology*; D013194:Staining and Labeling