title: [MicroRNAs as potential noninvasive markers in the diagnosis of urological malignancies].
abstract: Small non-coding RNAs (microRNAs) are involved in almost all biological mechanisms of carcinogenesis. Due to their stability in biological fluids microRNAs may serve a perspective biomarker for diagnosis and prognosis of oncological diseases. The review is dedicated to the analysis of microRNAs, as potential diagnostic markers of urological malignancies. Recent advances in the knowledge of miRNAs origin in body fluids, their stability and application as a potentially new class of biomarkers in medicine are summarized and discussed in the article.
authors.affiliation: Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences.
authors.forename: I R
authors.initials: IR
authors.lastname: Gilyazova
authors.affiliation: Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences.
authors.forename: E A
authors.initials: EA
authors.lastname: Klimentova
authors.affiliation: Bashkir State Medical University, Department of Urology, Ufa.
authors.forename: V N
authors.initials: VN
authors.lastname: Pavlov
authors.affiliation: Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences.|Bashkir State University, Department of Genetics and Fundamental Medicine.
authors.forename: E K
authors.initials: EK
authors.lastname: Khusnutdinova
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000378:metabolism*; D014571:Urologic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D012334:RNA, Neoplasm
keywords: microRNA; non-invasive diagnostics; prostate cancer; renal cell carcinoma; secretory microRNA; urothelial carcinoma