title: [New tools in cystic fibrosis].
abstract: The use of 3 novel tools available for the diagnosis and treatment in cystic fibrosis are described here. 1) The lung clearance index is a sensitive method which can detect functional impairment in the first months after birth. 2) Detailed morphological analyses of the lung can be performed with the new MRI sequences, without any contrast medium or risk of radiation. The analysis of functional MRI data (perfusion, diffusion, ventilation, inflammation) will be possible, and these data will be correlated to morphological data. The exploration of other organs such as the sinuses, liver and abdomen during the same examination represents another definite advantage. 3) Organoïds are a good example of personalized medicine. This tool explores CFTR function and treatment response in each of the 2000 or so known CFTR mutations. These tests are limited to specialized centers, mostly within a research context. However, their generalization after standardization is expected in the near future.
authors.affiliation: Université de Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, CIC 1401, F-33000 Bordeaux, France; CHU de Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service d'Exploration Fonctionnelle Respiratoire, CIC 1401, F-33600 Pessac, France.
authors.forename: G
authors.initials: G
authors.lastname: Dournes
authors.affiliation: Pediatric Pulmonology and Stem Cell Institute Leuven (SCIL), University of Leuven, Leuven, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: De Boeck
authors.affiliation: CHU de Bordeaux, CRCM pédiatrique, Centre d'Investigation Clinique (CIC 1401), F-33076 Bordeaux, France.
authors.forename: S
authors.initials: S
authors.lastname: Bui
authors.affiliation: Pediatric Pulmonology and Stem Cell Institute Leuven (SCIL), University of Leuven, Leuven, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Vermeulen
authors.affiliation: Pediatric Pulmonology and Stem Cell Institute Leuven (SCIL), University of Leuven, Leuven, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Ramalho
authors.affiliation: CHU de Bordeaux, Service d'Imagerie de la Femme et de l'Enfant, F-33000 Bordeaux, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Chateil
authors.affiliation: Université de Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, CIC 1401, F-33000 Bordeaux, France; CHU de Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service d'Exploration Fonctionnelle Respiratoire, CIC 1401, F-33600 Pessac, France.
authors.forename: F
authors.initials: F
authors.lastname: Laurent
authors.affiliation: Université de Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, CIC 1401, F-33000 Bordeaux, France; CHU de Bordeaux, CRCM pédiatrique, Centre d'Investigation Clinique (CIC 1401), F-33076 Bordeaux, France. Electronic address: michael.fayon@chu-bordeaux.fr.
authors.forename: M
authors.initials: M
authors.lastname: Fayon
mesh_terms: D002648:Child; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics*; D004252:DNA Mutational Analysis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D011379:Prognosis; D012129:Respiratory Function Tests
chemical_list: C505032:CFTR protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator