title: Positive association between metabolic syndrome and serum uric acid in Wuhan.
abstract: OBJECTIVE
  The objective was to determine whether serum uric acid concentrations were associated with metabolic syndrome in a population from Wuhan.
  
  
  METHODS
  5,628 subjects (2,838 men, 2,790 women) aged 18-80 years were recruited in Wuhan, China. Biochemical parameters of venous blood were measured by standard methods and metabolic syndrome was defined by Chinese Diabetes Society criteria. Association analysis was performed by logistic regression.
  
  
  RESULTS
  8.2% of the included subjects were confirmed as having metabolic syndrome and 14.4% were confirmed as having hyperuricemia. After multivariable adjustment, logistic regression showed the odds ratios of metabolic syndrome for subjects in the highest quartile of serum uric acid concentration was 2.84 (95% CI: 2.09-3.86) compared with those in the lowest quartile and no gender difference was found. For each component of metabolic syndrome, subjects in the highest quartile of serum uric acid concentrations had increased multivariable odds ratios for high BMI (OR: 3.29, 95% CI: 2.71-3.98), for hypertension (OR: 3.54, 95% CI: 2.93-3.86), for dyslipidemia (OR: 2.49, 95% CI: 1.98-3.14), but not for hyperglycemia (OR: 1.21, 95% CI: 0.87-1.67).
  
  
  CONCLUSIONS
  Odd ratio of metabolic syndrome was significantly positively associated with serum uric acid concentration among the present sample of 5,628 subjects in Wuhan.
authors.affiliation: Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.|Department of Maternal and Infant Nutrition, Beingmate Food Research Institute Co., Ltd, Hangzhou, China.
authors.forename: Yuan-Qing
authors.initials: YQ
authors.lastname: Fu
authors.affiliation: Wuhan Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.
authors.forename: Ju-Sheng
authors.initials: JS
authors.lastname: Zheng
authors.affiliation: Wuhan Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Zeng
authors.affiliation: Wuhan Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zeng
authors.affiliation: Wuhan Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Zhi-Fen
authors.initials: ZF
authors.lastname: Fan
authors.affiliation: Wuhan Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. Email: duoli@zju.edu.cn.
authors.forename: Duo
authors.initials: D
authors.lastname: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D033461:Hyperuricemia / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D014527:Uric Acid / Q000097:blood*
chemical_list: D008078:Cholesterol, LDL; D014527:Uric Acid