title: [New data on the effectiveness of Tadalafil alone and in combination with NeyroDoz in treating erectile dysfunction associated with secondary premature ejaculation].
abstract: OBJECTIVE
  To compare the effectiveness of the phosphodiesterase type 5 inhibitor (PDE-5i) tadalafil alone and in combination with a biologically active dietary supplement (BADS) NeyroDoz, containing the precursors of serotonin in patients with erectile dysfunction (ED) associated with secondary premature ejaculation (SPE).
  
  
  METHODS
  105 patients (mean age 36.2+/-9.1 years) with concomitant ED and SPE were included in a prospective study and divided into 2 groups. The patients of group 1 (n=47) received PDE-5i 5 mg daily for 1 month. In patients of group 2 (n=58) PDE-5i was co-administered with BADS 2 capsules twice daily. Treatment efficacy was evaluated using "Criteria for premature ejaculation" (CriPE) and IIEF-5 questionnaires at baseline and on completion of the treatment course. Besides, a polymorphism in the serotonin transporter gene (5-HTTLPR) was tested.
  
  
  RESULTS
  The treatment was effective in 35 (74.5%) and 48 (82.7%) patients of group 1 and 2, respectively (p<0.0001) with similar statistically significant (p<0.001) improvement in erectile function. According to CriPE scores, 6.4, 8.5, 23.4, 10.6 and 12.8% patients of group 1 and 10.3, 1.7, 40.0, 25.9, 10.3 and 31.0% patients of group 2 with LaLa, LaLg, LgLg, Sla, SLg, SS genotypes were rendered free of SPE, respectively.
  
  
  CONCLUSIONS
  Treating ED-associated SPE with the combination of serotonin precursors and tadalafil can better improve ejaculatory function recovery compared with PDE-5i monotherapy.
authors.affiliation: Research Institute for Uronephrology and Human Reproductive Health, I.M. Sechenov First MSMU.
authors.forename: N D
authors.initials: ND
authors.lastname: Akhvlediani
authors.affiliation: Research Institute for Uronephrology and Human Reproductive Health, I.M. Sechenov First MSMU.
authors.forename: I P
authors.initials: IP
authors.lastname: Matyukhov
mesh_terms: D000328:Adult; D001688:Biological Products / Q000627:therapeutic use*; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000150:complications / Q000188:drug therapy*; D005973:Glutamine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use*; D061686:Premature Ejaculation / Q000150:complications / Q000188:drug therapy*; D011446:Prospective Studies; D000068581:Tadalafil / Q000627:therapeutic use*; D014364:Tryptophan / Q000627:therapeutic use*
chemical_list: D001688:Biological Products; D004338:Drug Combinations; D058986:Phosphodiesterase 5 Inhibitors; D005973:Glutamine; D000068581:Tadalafil; D014364:Tryptophan
keywords: NeyroDoz; erectile dysfunction; premature ejaculation; serotonin