title: [Influence of n-hexane on vascular endothelial active substances in brain tissue in mice].
abstract: Objective:To investigate the influence of n-hexane on vascular endothelial active substances in brain tissue in mice and its significance.Methods:A total of 48 healthy Kunming mice were randomly divided into high-dose exposure group, middle-dose exposure group, low-dose exposure group, and control group, with 12 mice in each group. All groups except the control group were exposed to n-hexane via static inhalation (0.035 g/L, 0.018 g/L, and 0.009 g/L for the high-, middle-, and low-dose exposure groups, respectively) 4 hours a day for 21 days. the mice in the control groups were not exposed to n-hexane. After the exposure, the lev-els of endothelin-1 (ET-1) , nitric oxide (NO) , and angiotensin II (Ang II) in brain tissue were measured in all groups.Results:There were significant differences in the levels of ET-1, NO, and Ang II between the three ex-posure groups and the control group (P<0.05). Compared with the control group, the high-and middle-dose expo-sure group had significant increases in the levels of ET-1 and Ang II and the high-dose exposure group had a sig-nificant reduction in the level of NO (P<0.05 orP<0.01).Conclusion:n-Hexane can affect the vascular endothe-lial active substances in brain tissue in mice, and the changes and imbalance in vascular endothelial active sub-stances may be one of the reasons for central nervous system impairment caused by n-hexane.
authors.affiliation: Key Laboratory of Occupational Health & Environmental Medicine, School of Public Health, Jining Medical University, Jining 272067, China.
authors.forename: L
authors.initials: L
authors.lastname: Lin
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Zhang
authors.forename: C Z
authors.initials: CZ
authors.lastname: Zhang
mesh_terms: D000804:Angiotensin II; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D006586:Hexanes / Q000494:pharmacology*; D051379:Mice
chemical_list: D006586:Hexanes; D000804:Angiotensin II; C026385:n-hexane
keywords: AngiotenisnⅡ; Mice; n-hexane