title: Comparison of perioperative outcomes between laparoscopic and open surgery for mid-low rectal cancer with total mesorectal excision following neoadjuvant chemoradiotherapy.
abstract: OBJECTIVE
  The objective of our study was to determine the feasibility and safety of laparoscopic total mesorectal excision (TME) for mid-low rectal cancer following neoadjuvant chemoradiotherapy (nCRT).
  
  
  METHODS
  We retrospectively reviewed the records of 172 patients with locally advanced rectal cancer who underwent laparoscopic (n = 75) or conventional open (n = 97) surgery with TME following nCRT from June 2009 to October 2015. Perioperative outcomes and related clinical variables were collected and statistically analyzed.
  
  
  RESULTS
  Our results showed that patients who underwent laparoscopic surgery had significantly less blood loss and shorter time to pass first flatus and to start a liquid diet compared to those on open surgery. However, other perioperative outcomes, including operative times, postoperative morbidity rates, number of lymph nodes harvested, and sphincter preservation rates, were not significantly different between the two groups. After controlling for surgical approaches, we found that age, gender, tumor stages, and tumor distance to anal verge were significantly correlated with operative times in both groups. Likewise, age, body mass index, tumor T stages, and tumor distance to anal verge were predictors for postoperative morbidity in both groups.
  
  
  CONCLUSIONS
  We concluded that laparoscopic TME following nCRT is feasible and safe for patients with mid-low rectal cancer. Furthermore, tumor distance to anal verge and age are two important determinants of both operative times and postoperative morbidity, regardless of surgical option.
authors.affiliation: Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
authors.forename: Qiken
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
authors.forename: Pengnian
authors.initials: P
authors.lastname: Qiu
authors.affiliation: Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
authors.forename: Lai
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
authors.forename: Zhixuan
authors.initials: Z
authors.lastname: Fu
authors.affiliation: Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
authors.forename: Yongtian
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
authors.forename: Dechuan
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Radiology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
authors.forename: Lilong
authors.initials: L
authors.lastname: Tang
mesh_terms: D000328:Adult; D000368:Aged; D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000473:pathology* / Q000601:surgery* / Q000628:therapy; D016896:Treatment Outcome