title: Dermal absorption of semivolatile organic compounds from the gas phase: Sensitivity of exposure assessment by steady state modeling to key parameters.
abstract: Recent research has demonstrated the importance of dermal exposure for some semivolatile organic compounds (SVOCs) present in the gas phase of indoor air. Though models for estimating dermal intake from gaseous SVOCs exist, their predictions can be subject to variations in input parameters, which can lead to large variation in exposure estimations. In this sensitivity analysis for a steady state model, we aimed to assess these variations and their determinants using probabilistic Monte Carlo sampling for 8 SVOCs from different chemical families: phthalates, bisphenols, polycyclic aromatic hydrocarbons (PAHs), organophosphorus (OPs), organochlorines (OCs), synthetic musks, polychlorinated biphenyls (PCBs) and polybromodiphenylethers (PBDEs). Indoor SVOC concentrations were found to be the most influential parameters. Both Henry's law constant (H) and octanol/water partition coefficient (Kow) uncertainty also had significant influence. While exposure media properties such as volume fraction of organic matter in the particle phase (fom-part), particle density (ρpart), concentration ([TSP]) and transport coefficient (ɣd) had a slight influence for some compounds, human parameters such as body weight (W), body surface area (A) and daily exposure (t) make a marginal or null contribution to the variance of dermal intake for a given age group. Inclusion of a parameter sensitivity analysis appears essential to reporting uncertainties in dermal exposure assessment.
authors.affiliation: EHESP-School of Public Health, Sorbonne Paris Cité, Rennes, France; INSERM-U1085, Irset-Research Institute for Environmental and Occupational Health, Rennes, France.
authors.forename: Maud
authors.initials: M
authors.lastname: Pelletier
authors.affiliation: EHESP-School of Public Health, Sorbonne Paris Cité, Rennes, France; INSERM-U1085, Irset-Research Institute for Environmental and Occupational Health, Rennes, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bonvallot
authors.affiliation: University of Paris-Est, Scientific and Technical Center for Building (CSTB), Health and Comfort Department, French Indoor Air Quality Observatory (OQAI), 84 Avenue Jean Jaurès, Champs sur Marne, 77447 Marne la Vallée Cedex 2, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Ramalho
authors.affiliation: EHESP-School of Public Health, Sorbonne Paris Cité, Rennes, France; INSERM-U1085, Irset-Research Institute for Environmental and Occupational Health, Rennes, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Blanchard
authors.affiliation: EHESP-School of Public Health, Sorbonne Paris Cité, Rennes, France; INSERM-U1085, Irset-Research Institute for Environmental and Occupational Health, Rennes, France; LERES-Environment and Health Research Laboratory (Irset and EHESP Technologic Platform), Rennes, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Mercier
authors.affiliation: INSERM-U1085, Irset-Research Institute for Environmental and Occupational Health, Rennes, France; University of Paris-Est, Scientific and Technical Center for Building (CSTB), Health and Comfort Department, French Indoor Air Quality Observatory (OQAI), 84 Avenue Jean Jaurès, Champs sur Marne, 77447 Marne la Vallée Cedex 2, France; LERES-Environment and Health Research Laboratory (Irset and EHESP Technologic Platform), Rennes, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Mandin
authors.affiliation: EHESP-School of Public Health, Sorbonne Paris Cité, Rennes, France; INSERM-U1085, Irset-Research Institute for Environmental and Occupational Health, Rennes, France; LERES-Environment and Health Research Laboratory (Irset and EHESP Technologic Platform), Rennes, France.
authors.forename: Barbara
authors.initials: B
authors.lastname: Le Bot
authors.affiliation: EHESP-School of Public Health, Sorbonne Paris Cité, Rennes, France; INSERM-U1085, Irset-Research Institute for Environmental and Occupational Health, Rennes, France. Electronic address: philippe.glorennec@ehesp.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Glorennec
mesh_terms: D000393:Air Pollutants / Q000378:metabolism*; D016902:Air Pollution, Indoor / Q000032:analysis*; D005740:Gases / Q000378:metabolism*; D006801:Humans; D008962:Models, Theoretical; D009010:Monte Carlo Method; D012869:Skin Absorption; D055549:Volatile Organic Compounds / Q000378:metabolism*
chemical_list: D000393:Air Pollutants; D005740:Gases; D055549:Volatile Organic Compounds
keywords: Chemical; Contact; Indoor air; Monte Carlo; Percutaneous; Sensitivity analysis