title: Curcumin inhibits cancer progression through regulating expression of microRNAs.
abstract: Curcumin, a major yellow pigment and spice in turmeric and curry, is a powerful anti-cancer agent. The anti-tumor activities of curcumin include inhibition of tumor proliferation, angiogenesis, invasion and metastasis, induction of tumor apoptosis, increase of chemotherapy sensitivity, and regulation of cell cycle and cancer stem cell, indicating that curcumin maybe a strong therapeutic potential through modulating various cancer progression. It has been reported that microRNAs as small noncoding RNA molecules are related to cancer progression, which can be regulated by curcumin. Dysregulated microRNAs play vital roles in tumor biology via regulating expressions of target genes and then influencing multiple cancer-related signaling pathways. In this review, we focused on the inhibition effect of curcumin on various cancer progression by regulating expression of multiple microRNAs. Curcumin-induced dysregulation of microRNAs may activate or inactivate a set of signaling pathways, such as Akt, Bcl-2, PTEN, p53, Notch, and Erbb signaling pathways. A better understanding of the relation between curcumin and microRNAs may provide a potential therapeutic target for various cancers.
authors.affiliation: 1 The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, China.|2 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China.
authors.forename: Siying
authors.initials: S
authors.lastname: Zhou
authors.affiliation: 3 Department of Breath Internal Medicine, Suzhou Hospital of Traditional Chinese Medicine, Suzhou, China.
authors.forename: Sijie
authors.initials: S
authors.lastname: Zhang
authors.affiliation: 2 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China.|4 The Fourth Clinical School of Nanjing Medical University, Nanjing, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Shen
authors.affiliation: 5 Graduate School, Xuzhou Medical College, Xuzhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: 1 The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, China.|6 Department of Radiotherapy, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China.
authors.forename: Hanzi
authors.initials: H
authors.lastname: Xu
authors.affiliation: 2 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China.|4 The Fourth Clinical School of Nanjing Medical University, Nanjing, China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Chen
authors.affiliation: 2 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Sun
authors.affiliation: 7 Center of Clinical Laboratory Science, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, China.
authors.forename: Shanliang
authors.initials: S
authors.lastname: Zhong
authors.affiliation: 7 Center of Clinical Laboratory Science, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhao
authors.affiliation: 1 The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, China.|2 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China.|8 Jiangsu Province Hospital, Nanjing, China.
authors.forename: Jinhai
authors.initials: J
authors.lastname: Tang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D003474:Curcumin / Q000494:pharmacology* / Q000627:therapeutic use; D018450:Disease Progression; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D016032:Randomized Controlled Trials as Topic
chemical_list: D000970:Antineoplastic Agents; D035683:MicroRNAs; D003474:Curcumin
keywords: Curcumin; cancer; microRNA; signaling pathway; therapy