title: Inheritance of protection from osmotic stress.
abstract: Exposure of mother worms to mild osmotic stress induces gene expression changes in offspring that protect them from strong osmotic stress. Inheritance of protection is now shown to depend on altered insulin-like signalling in the maternal germline, which confers protection through increased expression of zygotic gpdh-2, a rate-limiting enzyme in glycerol biosynthesis.
authors.affiliation: Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA.
authors.forename: Kiyomi R
authors.initials: KR
authors.lastname: Kaneshiro
authors.affiliation: Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Strome
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000235:genetics* / Q000502:physiology*; D019610:Cytoprotection / Q000187:drug effects / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000187:drug effects; D040582:Inheritance Patterns / Q000187:drug effects / Q000235:genetics*; D007814:Larva / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D009997:Osmotic Pressure / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology; D013312:Stress, Physiological / Q000187:drug effects
chemical_list: D012965:Sodium Chloride