title: The aplication of cyanoacrilate surgical glue on skin suture in rats.
abstract: To compare the use of a new cyanoacrylate-based surgical glue and suture with sepa-rate points in skin wounds closure.
  Thirty-six rats were subjected to a 4cm dorsal longitudinal incision. Twelve were sub-jected to simple suture with polyamide 6-0, 12 rats underwent wall synthesis using Dermabond(r) and 12 was performed cutaneous synthesis with N-2-Butyl-Cyanoacrylate. Twelve of each group was euthanized on the seventh postoperative day, their blood was taken to biochemical tests and a layer of skin and subcutaneous tissue surrounding the surgical scar was randomly divided in two segments, to the submission of tension tests and to histological study.
  There were no significant difference between groups (p>0.05). In the soft dermis there was more type I collagen production in group I (p<0.05), group II and III was similar re-sults (p>0.05). In the compact dermis, all 3 groups showed similar results (p>0.05). The biomechanical study was similarity between the glue groups (p>0.05) but the group III proved to be different from the others having a higher resistance (p>0.05) .
  This glue does not cause any inflammation or kidney and hepatic toxicity. Polyamide sutures are more resistant and the glue should be used alone only in less tension are-as.
authors.affiliation: Fellow PhD degree, Postgraduate Program in Health and Development, Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande-MS, Brazil. Analysis and interpretation of data, manuscript writing.
authors.forename: João
authors.initials: J
authors.lastname: Ilgenfritz
authors.affiliation: PhD, Associate Professor, Department of Surgery, UFMS, Campo Grande-MS, Brazil. Guid-ance and experimental design.
authors.forename: Ricardo Dutra
authors.initials: RD
authors.lastname: Aydos
authors.affiliation: PhD, Associate Professor, Department of Surgery, UFMS, Campo Grande-MS, Brazil. Tech-nical procedures.
authors.forename: Iandara Schettert
authors.initials: IS
authors.lastname: Silva
authors.affiliation: PhD, Postgraduate Program in Health and Development, UFMS, Campo Grande-MS, Brazil. Technical procedures.
authors.forename: Rondon Tosta
authors.initials: RT
authors.lastname: Ramalho
authors.affiliation: MD, Universidade Federal do Rio Grande do Sul (UFRS), Porto Alegre-RS, Brazil. Analysis and interpretation of data, technical procedures, manuscript writing.
authors.forename: João
authors.initials: J
authors.lastname: Ilgenfritz
authors.affiliation: MD, UFMS, Campo Grande-MS, Brazil. Anesthesia procedures.
authors.forename: Gerson Gattats Orro de
authors.initials: GG
authors.lastname: Campos
authors.affiliation: MD, UFMS, Campo Grande-MS, Brazil. Anesthesia procedures.
authors.forename: Ricardo Kenithi
authors.initials: RK
authors.lastname: Nakamura
authors.affiliation: PhD, Associate Professor, UFMS, Campo Grande-MS, Brazil. Statistical analysis.
authors.forename: Danilo M Zanello
authors.initials: DM
authors.lastname: Guerisoli
authors.affiliation: PhD, Associate Professor, Department of Surgery, UFMS, Campo Grande-MS, Brazil. Critical revision, supervision all phases of the study.
authors.forename: Wilson de Barros
authors.initials: WB
authors.lastname: Cantero
mesh_terms: D000818:Animals; D003487:Cyanoacrylates / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D013536:Suture Techniques; D013997:Time Factors; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014945:Wound Healing
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives