title: Inhibition of Pancreatin-Induced Digestion of Cooked Rice Starch by Adzuki (Vigana angularis) Bean Flavonoids and the Possibility of a Decrease in the Inhibitory Effects in the Stomach.
abstract: Flavonoids of adzuki bean bind to starch when the beans are cooked with rice. The purpose of this study is to show that adzuki flavonoids can suppress pancreatin-induced digestion of cooked rice starch. The diethyl ether extract of water boiled with adzuki bean inhibited starch digestion, and quercetin and a cyanidin-catechin conjugate (vignacyanidin) but not taxifolin in the extract contributed to the inhibition. The order of their inhibitory effects (taxifolin < quercetin < vignacyanidin) suggested that the effects increased with an increase in their hydrophobicity. The diethyl ether extract also inhibited the starch digestion of cooked rice preincubated in artificial gastric juice, and the level of inhibition was decreased by nitrite. The decrease was due to nitrite-induced consumption of quercetin and vignacyanidin. Taking these results into account, we discuss mechanisms of quercetin- and vignacyanidin-dependent inhibition of starch digestion and the possibility of the decrease in their inhibitory effects by nitrite in the stomach.
authors.affiliation: Department of Health and Nutrition Care, Faculty of Allied Health Sciences, University of East Asia , Shimonoseki 751-8503, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Hirota
authors.affiliation: Department of Health and Nutrition Care, Faculty of Allied Health Sciences, University of East Asia , Shimonoseki 751-8503, Japan.
authors.forename: Umeo
authors.identifier: http://orcid.org/0000-0001-5773-605X
authors.initials: U
authors.lastname: Takahama
mesh_terms: D003296:Cooking; D004063:Digestion; D007887:Fabaceae / Q000737:chemistry / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D012275:Oryza / Q000737:chemistry / Q000378:metabolism*; D010194:Pancreatin / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism*; D012639:Seeds / Q000737:chemistry / Q000378:metabolism; D013213:Starch / Q000737:chemistry / Q000378:metabolism*
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; D010194:Pancreatin; D013213:Starch
keywords: flavonoid/starch complex; nitrite; quercetin; starch digestion; stomach; vignacyanidin