title: MRI Study for the Features of Brain Conduction Pathways in Patients with an Ultra-High Risk of Endogenous Psychoses.
abstract: Diffusion parameters of brain tracts (n=18) were studied in 27 men with ultra-high risk of endogenous attack-like psychoses and 27 mentally healthy men of the same age group (fractional anisotropy; and average, radial, and axial diffusion). Correlation analysis was performed between these parameters and severity of mental disorders (SOPS scale). The indexes of radial diffusion and axial diffusion were shown to change in the left anterior thalamic radiation and right posterior cingulum bundle, respectively. Our results are consistent with published data that disturbances in the frontal and temporal lobes play an important role in the pathogenesis of schizophrenia. The degree of mental disorders correlated with diffusion parameters in the left and right anterior cingulum bundle.
authors.affiliation: Mental Health Research Center, Moscow, Russia. alexander.tomyshev@gmail.com.
authors.forename: A S
authors.initials: AS
authors.lastname: Tomyshev
authors.affiliation: Mental Health Research Center, Moscow, Russia.
authors.forename: I S
authors.initials: IS
authors.lastname: Lebedeva
authors.affiliation: Emergency Children's Surgery and Traumatology Research Institute, Moscow, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Akhadov
authors.affiliation: Mental Health Research Center, Moscow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Omel'chenko
authors.affiliation: Emergency Children's Surgery and Traumatology Research Institute, Moscow, Russia.|N. M. Emanuel Institute of Biochemical Physics, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Ublinskii
authors.affiliation: Emergency Children's Surgery and Traumatology Research Institute, Moscow, Russia.|N. M. Emanuel Institute of Biochemical Physics, Moscow, Russia.|N. N. Semenov Institute of Chemical Physics, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Semenova
authors.affiliation: Mental Health Research Center, Moscow, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Kaleda
mesh_terms: D000293:Adolescent; D000328:Adult; D016880:Anisotropy; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000473:pathology* / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D005625:Frontal Lobe / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D012559:Schizophrenia / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000473:pathology* / Q000503:physiopathology; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology; D066127:White Matter / Q000473:pathology* / Q000503:physiopathology
keywords: frontal lobes; magnetic resonance imaging (MRI); schizophrenia; tractography; ultra-high risk