title: Predictors of Obstructive Sleep Apnea Severity in Adolescents.
abstract: Untreated obstructive sleep apnea has severe health consequences, yet little is known about predictors of sleep apnea severity in the adolescent population.
  
  
  
  To evaluate clinical and demographic factors associated with obstructive sleep apnea severity in adolescents.
  
  
  
  A retrospective case series of 224 children (53% male), ages 12 to 17 years who underwent polysomnography from January 1, 2013, to June 4, 2015. The study was carried out in a large tertiary referral children's hospital associated with an academic medical center in Dallas, Texas. Children were excluded if they were missing clinical data (eg, tonsil size), had major comorbidities (eg, chromosomal abnormalities), or had previously undergone tonsillectomy and adenoidectomy. The mean (SD) age was 14.6 (1.7) years (range, 12.0-17.9 years), and the patients were 55% Hispanic, 30% African American, 13% white, and 2% other.
  
  
  
  Electronic medical records were reviewed for demographic, clinical, and polysomnographic parameters.
  
  
  
  Correlation between demographic and clinical characteristics and the apnea hypopnea index.
  
  
  
  In 224 adolescents (53% male) aged 12 to 17 years, the mean (SD) apnea hypopnea index was 14.9 (28.7) (range, 0.0-187.7) and was positively correlated with CDC-defined weight categories (P = .04) and tonsillar hypertrophy (P < .001). Sex, ethnicity, and age were not associated with the apnea hypopnea index. Severe obstructive sleep apnea (apnea hypopnea index >10) was more common in males (OR, 1.8; 95% CI, 1.0-3.2), patients with tonsillar hypertrophy (OR, 3.2; 95% CI, 1.8-5.8), and patients in a heavier CDC weight class (OR, 2.0; 95% CI, 1.3-3.2). Age and ethnicity did not predict severe obstructive sleep apnea.
  
  
  
  Obstructive sleep apnea in adolescents is associated with obesity and tonsillar hypertrophy in this study. Severe obstructive sleep apnea is more likely in adolescents who are male or obese, or who have tonsillar hypertrophy. This study supports routine polysomnography in obese male adolescents with tonsillar hypertrophy and symptoms of sleep-disordered breathing to screen for and treat severe obstructive sleep apnea.
authors.affiliation: University of Texas Southwestern Medical Center, Dallas.
authors.forename: Mark
authors.initials: M
authors.lastname: Baker
authors.affiliation: University of Texas Southwestern Medical Center, Dallas.
authors.forename: Brian
authors.initials: B
authors.lastname: Scott
authors.affiliation: University of Texas Southwestern Medical Center, Dallas2Children's Health, Children's Medical Center Dallas, Dallas, Texas.
authors.forename: Romaine F
authors.initials: RF
authors.lastname: Johnson
authors.affiliation: University of Texas Southwestern Medical Center, Dallas2Children's Health, Children's Medical Center Dallas, Dallas, Texas.
authors.forename: Ron B
authors.initials: RB
authors.lastname: Mitchell
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D014066:Palatine Tonsil / Q000473:pathology; D017286:Polysomnography; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000453:epidemiology; D013781:Texas / Q000453:epidemiology