title: Case of a cerebral abscess caused byPorphyromonas gingivalisin a subject with periodontitis.
abstract: We report the case of a 65-year-old man presenting with generalised seizures after developing a right frontal brain abscess. Stereotactic aspiration and subsequent matrix assisted laser desorption/ionisation time-of-flight analyzer (MALDI-TOF) spectrometry revealedPorphyromonas gingivalisas the only causative anaerobe microorganism. Secondary incision and drainage was required due to neurological deterioration with increased dimensions of the abscess, intracranial pressure and formation of a subdural occipitoparietal empyema. Oral imaging was positive for apical periodontitis of multiple elements; therefore, the remaining dentition was removed. Targeted antibiotic treatment included intravenous ceftriaxone and ornidazole. The patient was discharged to our revalidation unit 59 days after admission to make a full recovery. To the best of our knowledge, this is the sixth reported case ofP. gingivaliscausing an intracranial abscess and the third case of a true intracerebral parenchymal abscess caused by this bacterium.
authors.affiliation: OMFS-IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium.
authors.forename: Frederic
authors.identifier: http://orcid.org/0000-0002-6888-9219
authors.initials: F
authors.lastname: Van der Cruyssen
authors.affiliation: OMFS-IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium.
authors.forename: Koenraad
authors.initials: K
authors.lastname: Grisar
authors.affiliation: OMFS-IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium.
authors.forename: Honorine
authors.initials: H
authors.lastname: Maes
authors.affiliation: OMFS-IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium.
authors.forename: Constantinus
authors.initials: C
authors.lastname: Politis
mesh_terms: D000368:Aged; D016866:Bacteroidaceae Infections / Q000150:complications*; D001922:Brain Abscess / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010518:Periodontitis / Q000150:complications* / Q000628:therapy; D016966:Porphyromonas gingivalis