title: [Impact and changes of maternal hemoglobin on birth weight in pregnant women of Zhuang Nationality, in Guangxi].
abstract: Objective:To investigate the hemoglobin (Hb) levels during pregnancy and Hb changes from early pregnancy and association with birth weight on infants.Methods:Mothers of Zhuang Nationality who participated in the pregnancy care program and delivered at the Pingguo County Hospital from May 2013 to May 2015 were included in this study. Retrospective analysis was applied to collect data of health care and pregnancy outcomes. Multiple regression analysis and unconditional logistic regression model were used for data analysis.Results:The mean birth weight appeared as (313 5.92±435.84) grams. The Hb levels at early pregnancy showed significantly positive association with birth weight. Results from our study demonstrated that when Hb levels increased + 1 g/dl at early pregnancy, birth weight would increase 17.61(95% CI: 0.60-34.67) grams, in the adjusted model. The Hb levels at late pregnancy were significantly inversely associated with birth weight. Our findings suggested that when Hb levels increased + 1 g/dl at late pregnancy, birth weight would reduce 19.61(95% CI: -37.53 --1.70) grams in the adjusted model. Changes in Hb from early pregnancy stages were significantly inversely associated with birth weight after adjusting for confounders and Hb levels in the early pregnancy stages. The results also indicated that when Hb levels increased a + 1 g/dl from early to late pregnancy, the birth weight would decrease 32.63 g(95% CI: -48.93--16.32). Compared to the non-anemia group, the anemia group showed significantly increase of small-for-gestational-age (SGA)(OR=1.58, 95%CI: 1.08-2.32) in early pregnancy. Compared to women under the most reduction status, women with the least reduction had a significantly increase of SGA (OR= 1.87, 95% CI:1.24-2.81) among their infants. With the magnitude of reduction on Hb concentration during pregnancy, the risk of delivering babies with SGA showed a gradual trends of increase.Conclusion:Hb levels at early pregnancy were positively associated with birth weight, but the changes of Hb were inversely associated with birth weight at late pregnancy, in women of Zhuang Nationality. Anemia in early pregnancy and the low amplitude of decreased Hb concentration during pregnancy were both risk factors for newborns under less gestational ages.
authors.affiliation: Department of Epidemiology and Health Statistic, School of Public Health, Guangxi Medical University, Nanning 530021, China.
authors.forename: J H
authors.initials: JH
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Health Statistic, School of Public Health, Guangxi Medical University, Nanning 530021, China.
authors.forename: X F
authors.initials: XF
authors.lastname: Guo
authors.affiliation: Department of Epidemiology and Health Statistic, School of Public Health, Guangxi Medical University, Nanning 530021, China.
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Health Statistic, School of Public Health, Guangxi Medical University, Nanning 530021, China.
authors.forename: J H
authors.initials: JH
authors.lastname: Long
authors.affiliation: Department of Epidemiology and Health Statistic, School of Public Health, Guangxi Medical University, Nanning 530021, China.
authors.forename: G Q
authors.initials: GQ
authors.lastname: Zhang
authors.affiliation: Department of maternity, Pingguo County Child Health, Baise 531400, China.
authors.forename: M C
authors.initials: MC
authors.lastname: Huang
authors.affiliation: Department of Epidemiology and Health Statistic, School of Public Health, Guangxi Medical University, Nanning 530021, China.
authors.forename: X Q
authors.initials: XQ
authors.lastname: Qiu
mesh_terms: D000328:Adult; D000740:Anemia / Q000150:complications* / Q000175:diagnosis / Q000208:ethnology; D001724:Birth Weight; D002681:China / Q000453:epidemiology; D036861:Delivery, Obstetric; D005006:Ethnicity; D005260:Female; D005865:Gestational Age; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000208:ethnology*; D011256:Pregnancy Outcome / Q000453:epidemiology; D011264:Pregnancy Trimesters / Q000097:blood*; D047928:Premature Birth / Q000097:blood* / Q000208:ethnology; D011295:Prenatal Care; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D006454:Hemoglobins
keywords: Birth weight; Hemoglobin; Pregnancy