title: Chronic tophaceous gout in patients with psoriasis.
abstract: Psoriasis is a chronic inflammatory disease of multifactorial etiology influenced by genetic, immunological, and environmental factors. We report the case of a patient with psoriasis for more than 25 years who developed hyperuricemia and chronic tophaceous gout with unusual appearance. In psoriasis, hyperuricemia may occur by increased epidermal cell turnover, which accelerates purine metabolism and has uric acid as the product of its catabolism. The association of psoriasis with hyperuricemia can trigger the onset of gouty arthritis, and pose a greater risk of developing other inflammatory comorbidities. Therefore, it is important to periodically investigate uric acid levels in order to treat changes triggered by hyperuricemia.
authors.affiliation: Private Clinic - Manaus (AM), Brazil.
authors.forename: Laís Cruz
authors.initials: LC
authors.lastname: Lobato
authors.affiliation: Private Clinic - Manaus (AM), Brazil.
authors.forename: Jéssica Castiel
authors.initials: JC
authors.lastname: Coutinho
authors.affiliation: Department of Mycology - School of Pharmaceutical Sciences - Universidade Federal do Amazonas (UFAM) - Manaus (AM), Brazil.
authors.forename: Maria Zeli Moreira
authors.initials: MZ
authors.lastname: Frota
authors.affiliation: Department of Dermatopathology - Fundação Alfredo da Matta (FUAM) - Manaus (AM), Brazil.
authors.forename: Antonio Pedro Mendes
authors.initials: AP
authors.lastname: Schettini
authors.affiliation: Department of Psoriasis - Fundação Alfredo da Matta (FUAM) - Manaus (AM), Brazil.|School of Medicine - Universidade do Estado do Amazonas (UEA) - Manaus (AM), Brazil.
authors.forename: Mônica
authors.initials: M
authors.lastname: Santos
mesh_terms: D002908:Chronic Disease; D006073:Gout / Q000209:etiology* / Q000473:pathology; D006801:Humans; D033461:Hyperuricemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications*