title: Clinical association between Kikuchi׳s disease and systemic lupus erythematosus: A systematic literature review.
abstract: To perform a systematic review of all cases of the association between Kikuchi's disease (KD) and systemic lupus erythematosus (SLE), and to ascertain the clinical and laboratory characteristics of this association (KD-SLE).
  
  
  
  We conducted a systematic search of the scientific literature until 31 January 2016. For study purposes, only patients aged >14 years, with histologically proven KD, definite SLE and adequate clinical data were included. To compare KD-SLE against isolated KD and SLE, we selected 2 large series of patients with KD and 4 series of SLE patients.
  
  
  
  The search found 158 adults with proven KD-SLE. Of these, 113 with sufficient clinical information were included; 86 were women (female:male ratio = 5.0); mean age at diagnosis was 34 years (range: 14-56 years); and an ethnic distribution of 50.5% Asian, 34% Caucasian, and 15% other. KD-SLE patients differed significantly from patients with isolated KD, presenting with a higher frequency of high fever (90%), severe KD (88%), and extranodal manifestations. When compared to patients with SLE, those with KD-SLE presented with a higher frequency of fever and systemic symptoms and a lower frequency of lupus nephritis (22%). SLE had been diagnosed before KD in 18% of cases, simultaneously in 51%, and after KD in 31%. No significant differences were found in terms of time of diagnosis.
  
  
  
  While KD-SLE patients share many clinical and laboratory manifestations with SLE, they differ in a lower frequency of lupus nephritis. The relative time of diagnosis of each disease did not affect the clinical expression of KD-SLE.
authors.affiliation: Departamento de Medicina Interna, Hospital Clínico Universitario, Complexo Hospitalario Universitario de Santiago de Compostela, A Coruña 15706, Spain; Departamento de Medicina, Facultad de Medicina, Universidad de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain. Electronic address: bsopena@gmail.com.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Sopeña
authors.affiliation: Thrombosis and Vasculitis Unit, Complexo Hospitalario Universitario de Vigo, Vigo, Pontevedra, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Rivera
authors.affiliation: Department of Medicine, Facultad de Medicina, Hospital Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Chamorro
authors.affiliation: Thrombosis and Vasculitis Unit, Complexo Hospitalario Universitario de Vigo, Vigo, Pontevedra, Spain.
authors.forename: Mayka
authors.initials: M
authors.lastname: Freire
authors.affiliation: Departamento de Medicina Interna, Hospital Clínico Universitario, Complexo Hospitalario Universitario de Santiago de Compostela, A Coruña 15706, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Alende
authors.affiliation: Department of Medicine, Facultad de Medicina, Hospital Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Seco
authors.affiliation: Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Facultad de Medicina Universidad de Cantabria, Santander, Spain.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: González-Gay
authors.affiliation: Departamento de Medicina Interna, Hospital Clínico Universitario, Complexo Hospitalario Universitario de Santiago de Compostela, A Coruña 15706, Spain; Departamento de Medicina, Facultad de Medicina, Universidad de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.
authors.forename: Arturo
authors.initials: A
authors.lastname: González-Quintela
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D008181:Lupus Nephritis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D055815:Young Adult
keywords: Histiocytic necrotizing Lymphadenitis; Kikuchi’s disease; Systemic lupus erythematosus