title: The discovery of fluazaindolizine: A new product for the control of plant parasitic nematodes.
abstract: Fluazaindolizine is a new highly effective and selective product for the control of plant parasitic nematodes. Specificity for nematodes coupled with absence of activity against the target sites of commercial nematicides suggests that fluazaindolizine has a novel mode of action. The discovery, structure-activity development and biological properties for this new class of nematicides are presented.
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1090 Elkton Rd., Newark, DE 19714, USA. Electronic address: george.p.lahm@dupont.com.
authors.forename: George P
authors.initials: GP
authors.lastname: Lahm
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1090 Elkton Rd., Newark, DE 19714, USA.
authors.forename: Johan
authors.initials: J
authors.lastname: Desaeger
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1090 Elkton Rd., Newark, DE 19714, USA.
authors.forename: Ben K
authors.initials: BK
authors.lastname: Smith
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1090 Elkton Rd., Newark, DE 19714, USA.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Pahutski
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1090 Elkton Rd., Newark, DE 19714, USA.
authors.forename: Michel A
authors.initials: MA
authors.lastname: Rivera
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1090 Elkton Rd., Newark, DE 19714, USA.
authors.forename: Tony
authors.initials: T
authors.lastname: Meloro
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1090 Elkton Rd., Newark, DE 19714, USA.
authors.forename: Roman
authors.initials: R
authors.lastname: Kucharczyk
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1090 Elkton Rd., Newark, DE 19714, USA.
authors.forename: Renee M
authors.initials: RM
authors.lastname: Lett
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1090 Elkton Rd., Newark, DE 19714, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Daly
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1090 Elkton Rd., Newark, DE 19714, USA.
authors.forename: Brenton T
authors.initials: BT
authors.lastname: Smith
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1090 Elkton Rd., Newark, DE 19714, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Cordova
authors.affiliation: DuPont de Nemours (France) S.A.S., European Research Center, 68740 Nambsheim, France.
authors.forename: Tim
authors.initials: T
authors.lastname: Thoden
authors.affiliation: DuPont (U.K.) Limited, 4th Floor, Kings Court, London Road, Stevenage SG1 2NG, United Kingdom.
authors.forename: John A
authors.initials: JA
authors.lastname: Wiles
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects; D018556:Crops, Agricultural / Q000469:parasitology; D004331:Drosophila melanogaster / Q000187:drug effects; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D007212:Indolizines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D010575:Pesticides / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D018517:Plant Roots / Q000469:parasitology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D014431:Tylenchoidea / Q000187:drug effects
chemical_list: D006574:Heterocyclic Compounds, 2-Ring; D007212:Indolizines; D010575:Pesticides; D013449:Sulfonamides; C000621530:fluazaindolizine
keywords: Fluazaindolizine; Nematicide; Plant parasitic nematodes; Structure-activity relationships