title: Mannose-Binding Lectin: Biologic Characteristics and Role in the Susceptibility to Infections and Ischemia-Reperfusion Related Injury in Critically Ill Neonates.
abstract: The mannose-binding lectin (MBL) is a member of the collectin family, belonging to the innate immunity system. Genetic, biologic, and clinical properties of MBL have been widely investigated throughout the last decades, although some interesting aspects of its potential clinical relevance are still poorly understood. Low circulating concentrations of MBL have been associated with increased risk of infection and poor neurologic outcome in neonates. On the other hand, an excessive and uncontrolled inflammatory response by the neonatal intestine after the exposure to luminal bacteria, leading to an increased production of MBL, may be involved in the onset of necrotizing enterocolitis. The purpose of the present review is to summarize the current knowledge about genetic and biologic characteristics of MBL and its role in the susceptibility to infections and to ischemia-reperfusion related tissue injuries to better explore its clinical relevance during the perinatal period and the possible future therapeutic applications.
authors.affiliation: Department of Medical and Surgical Neonatology, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio 4, 00165 Rome, Italy.
authors.forename: Cinzia
authors.identifier: 0000-0001-9820-6557
authors.initials: C
authors.lastname: Auriti
authors.affiliation: Department of Laboratories, Laboratory of Rheumatology, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio 4, 00165 Rome, Italy.
authors.forename: Giusi
authors.identifier: 0000-0003-1152-9041
authors.initials: G
authors.lastname: Prencipe
authors.affiliation: Department of Pediatrics, Anna Meyer Children's University Hospital, Viale Gaetano Pieraccini 24, 50139 Florence, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Moriondo
authors.affiliation: Department of Medical and Surgical Neonatology, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio 4, 00165 Rome, Italy.
authors.forename: Iliana
authors.identifier: 0000-0002-3020-2274
authors.initials: I
authors.lastname: Bersani
authors.affiliation: Department of Medical and Surgical Neonatology, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio 4, 00165 Rome, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Bertaina
authors.affiliation: Department of Medical and Surgical Neonatology, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio 4, 00165 Rome, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Mondì
authors.affiliation: Department of Laboratories, Laboratory of Chemical Chemistry, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio 4, 00165 Rome, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Inglese
mesh_terms: D016638:Critical Illness; D004198:Disease Susceptibility; D020345:Enterocolitis, Necrotizing / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007113:Immunity, Innate; D007231:Infant, Newborn; D007234:Infant, Premature; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D011110:Polymorphism, Genetic; D015427:Reperfusion Injury / Q000209:etiology* / Q000276:immunology
chemical_list: D037601:Mannose-Binding Lectin