title: Neural correlates of an attentional bias to health-threatening stimuli in individuals with pathological health anxiety.
abstract: An attentional bias to health-threat stimuli is assumed to represent the primary pathogenetic factor for the development and maintenance of pathological health anxiety (PHA; formerly termed "hypochondriasis"). However, little is known about the neural basis of this attentional bias in individuals with PHA.
  
  
  
  A group of patients with PHA, a group of depressed patients and a healthy control group completed an emotional Stroop task with health-threat (body symptom and illness) words and neutral control words while undergoing functional MRI.
  
  
  
  We included 33 patients with PHA, 28 depressed patients and 31 controls in our analyses. As reflected in reaction times, patients with PHA showed a significantly stronger attentional bias to health-threat words than both control groups. In addition, patients with PHA showed increased amygdala and rostral anterior cingulate cortex activation for body symptom, but not for illness words. Moreover, only in patients with PHA amygdala activation in response to symptom words was positively associated with higher arousal and more negative valence ratings of the body symptom word material.
  
  
  
  A control group of patients with an anxiety disorder but without PHA would have helped to define the specificity of the results for PHA.
  
  
  
  The attentional bias observed in patients with PHA is associated with hyperactivation in response to body symptom words in brain regions that are crucial for an arousal-related fear response (e.g., the amygdala) and for resolving emotional interference (e.g., the rostral anterior cingulate cortex). The findings have important implications for the nosological classification of PHA and suggest the application of innovative exposure-based interventions for the treatment of PHA.
authors.affiliation: From the Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany (Mier, Bailer, Ofer, Kerstner, Zamoscik, Diener); the University of Münster, Münster, Germany (Rist); the Johannes Gutenberg University, Mainz, Germany (Witthöft); and the SRH University of Applied Sciences Heidelberg, Germany (Diener).
authors.forename: Daniela
authors.initials: D
authors.lastname: Mier
authors.affiliation: From the Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany (Mier, Bailer, Ofer, Kerstner, Zamoscik, Diener); the University of Münster, Münster, Germany (Rist); the Johannes Gutenberg University, Mainz, Germany (Witthöft); and the SRH University of Applied Sciences Heidelberg, Germany (Diener).
authors.forename: Josef
authors.initials: J
authors.lastname: Bailer
authors.affiliation: From the Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany (Mier, Bailer, Ofer, Kerstner, Zamoscik, Diener); the University of Münster, Münster, Germany (Rist); the Johannes Gutenberg University, Mainz, Germany (Witthöft); and the SRH University of Applied Sciences Heidelberg, Germany (Diener).
authors.forename: Julia
authors.initials: J
authors.lastname: Ofer
authors.affiliation: From the Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany (Mier, Bailer, Ofer, Kerstner, Zamoscik, Diener); the University of Münster, Münster, Germany (Rist); the Johannes Gutenberg University, Mainz, Germany (Witthöft); and the SRH University of Applied Sciences Heidelberg, Germany (Diener).
authors.forename: Tobias
authors.initials: T
authors.lastname: Kerstner
authors.affiliation: From the Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany (Mier, Bailer, Ofer, Kerstner, Zamoscik, Diener); the University of Münster, Münster, Germany (Rist); the Johannes Gutenberg University, Mainz, Germany (Witthöft); and the SRH University of Applied Sciences Heidelberg, Germany (Diener).
authors.forename: Vera
authors.initials: V
authors.lastname: Zamoscik
authors.affiliation: From the Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany (Mier, Bailer, Ofer, Kerstner, Zamoscik, Diener); the University of Münster, Münster, Germany (Rist); the Johannes Gutenberg University, Mainz, Germany (Witthöft); and the SRH University of Applied Sciences Heidelberg, Germany (Diener).
authors.forename: Fred
authors.initials: F
authors.lastname: Rist
authors.affiliation: From the Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany (Mier, Bailer, Ofer, Kerstner, Zamoscik, Diener); the University of Münster, Münster, Germany (Rist); the Johannes Gutenberg University, Mainz, Germany (Witthöft); and the SRH University of Applied Sciences Heidelberg, Germany (Diener).
authors.forename: Michael
authors.initials: M
authors.lastname: Witthöft
authors.affiliation: From the Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany (Mier, Bailer, Ofer, Kerstner, Zamoscik, Diener); the University of Münster, Münster, Germany (Rist); the Johannes Gutenberg University, Mainz, Germany (Witthöft); and the SRH University of Applied Sciences Heidelberg, Germany (Diener).
authors.forename: Carsten
authors.initials: C
authors.lastname: Diener
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000503:physiopathology*; D000070379:Attentional Bias / Q000502:physiology*; D001294:Attitude to Health; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004644:Emotions; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011930:Reaction Time; D011932:Reading; D057190:Stroop Test; D014796:Visual Perception