title: Theiler's murine encephalomyelitis virus infection of SJL/J and C57BL/6J mice: Models for multiple sclerosis and epilepsy.
abstract: Mouse models are great tools to study the mechanisms of disease development. Theiler's murine encephalomyelitis virus is used in two distinct viral infection mouse models to study the human diseases multiple sclerosis (MS) and epilepsy. Intracerebral (i.c.) infection of the SJL/J mouse strain results in persistent viral infection of the central nervous system and a MS-like disease, while i.c. infection of the C57BL/6J mouse strain results in acute seizures and epilepsy. Our understanding of how the immune system contributes to the development of two disparate diseases caused by the same virus is presented.
authors.affiliation: Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.
authors.forename: Ana Beatriz
authors.initials: AB
authors.lastname: DePaula-Silva
authors.affiliation: Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.
authors.forename: Tyler J
authors.initials: TJ
authors.lastname: Hanak
authors.affiliation: Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Libbey
authors.affiliation: Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA. Electronic address: Robert.Fujinami@hsc.utah.edu.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Fujinami
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001402:B-Lymphocytes / Q000473:pathology / Q000821:virology; D004195:Disease Models, Animal; D018450:Disease Progression; D004827:Epilepsy / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000821:virology; D008264:Macrophages / Q000473:pathology / Q000821:virology; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D017628:Microglia / Q000473:pathology / Q000821:virology; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000821:virology; D011051:Poliomyelitis / Q000150:complications*; D013601:T-Lymphocytes / Q000473:pathology / Q000821:virology; D017945:Theilovirus / Q000472:pathogenicity*
chemical_list: D015703:Antigens, CD
keywords: Epilepsy; Immune response; Mouse model; Multiple sclerosis (MS); Seizures; Theiler's murine encephalomyelitis virus (TMEV)