title: Multidisciplinary consensus on the therapeutic recommendations for iatrogenic hyperprolactinemia secondary to antipsychotics.
abstract: Hyperprolactinemia is an underappreciated/unknown adverse effects of antipsychotics. The consequences of hyperprolactinemia compromise therapeutic adherence and can be serious. We present the consensus recommendations made by a group of experts regarding the management of antipsychotic-induced hyperprolactinemia. The current consensus was developed in 3 phases: 1, review of the scientific literature; 2, subsequent round table discussion to attempt to reach a consensus among the experts; and 3, review by all of the authors of the final conclusions until reaching a complete consensus. We include recommendations on the appropriate time to act after hyperprolactinemia detection and discuss the evidence on available options: decreasing the dose of the antipsychotic drug, switching antipsychotics, adding aripiprazole, adding dopaminergic agonists, and other type of treatment. The consensus also included recommendations for some specific populations such as patients with a first psychotic episode and the pediatric-youth population, bipolar disorder, personality disorders and the elderly population.
authors.affiliation: Neurosciences Area, Instituto de Biomedicina de Salamanca (IBSAL), University of Salamanca, Psychiatry Department, University Hospital of Salamanca, Salamanca, Spain. Electronic address: amontejo@usal.es.
authors.forename: Ángel L
authors.initials: ÁL
authors.lastname: Montejo
authors.affiliation: Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), IiSGM, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
authors.affiliation: Barcelona Clínic Schizophrenia Unit, Neuroscience Institute, Hospital Clínic of Barcelona, Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
authors.forename: Miquel
authors.initials: M
authors.lastname: Bernardo
authors.affiliation: Instituto de Investigación Sanitaria, Hospital Clínico San Carlos, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: Carrasco
authors.affiliation: Department of Medicine & Psychiatry, University Hospital Marqués de Valdecilla, IDIVAL, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Santander, Spain.
authors.forename: Benidicto
authors.initials: B
authors.lastname: Crespo-Facorro
authors.affiliation: Department of Medical Oncology, Instituto de Biomedicina de Salamanca (IBSAL), University of Salamanca, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Cruz
authors.affiliation: Internal Medicine Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Del Pino-Montes
authors.affiliation: Psychiatry Hospitalization Unit, Hospital General y Universitario de Elche, Elche, Spain.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: García-Escudero
authors.affiliation: Barcelona Clínic Schizophrenia Unit, Neuroscience Institute, Hospital Clínic of Barcelona, Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
authors.forename: Clemente
authors.initials: C
authors.lastname: García-Rizo
authors.affiliation: International Mood Disorders Research Centre, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Hospital Santiago Apóstol, University of the Basque Country, Vitoria, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: González-Pinto
authors.affiliation: FEA Psiquiatría, Red de Salud Mental de Guipúzcoa, San Sebastián, Spain.
authors.forename: Ana I
authors.initials: AI
authors.lastname: Hernández
authors.affiliation: Institute of Psychiatric Research, Mª Josefa Recio Foundation, Bilbao, Spain; Psychiatry Clinic Padre Menni, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Pamplona, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Martín-Carrasco
authors.affiliation: University Regional Hospital of Malaga, Biomedical Research Institute (IBIMA), Malaga, Spain.
authors.forename: Fermín
authors.initials: F
authors.lastname: Mayoral-Cleries
authors.affiliation: Sierrallana Hospital, Torrelavega, Cantabria, Spain.
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Mayoral-van Son
authors.affiliation: Endocrinology and Nutrition Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Mories
authors.affiliation: Bipolar Disorders Program, Psychiatry Department, Hospital Clinic, University of Barcelona, IDIBAPS, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
authors.forename: Isabella
authors.initials: I
authors.lastname: Pachiarotti
authors.affiliation: Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Jesús
authors.initials: J
authors.lastname: Pérez
authors.affiliation: International Institute of Applied Neurosciences, Barcelona, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Ros
authors.affiliation: Bipolar Disorders Program, Psychiatry Department, Hospital Clinic, University of Barcelona, IDIBAPS, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
authors.forename: Eduard
authors.initials: E
authors.lastname: Vieta
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D000068180:Aripiprazole / Q000627:therapeutic use*; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy*; D007049:Iatrogenic Disease / Q000517:prevention & control; D001523:Mental Disorders / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D000068180:Aripiprazole
keywords: Antipsychotic; Consensus; Hyperprolactinemia; Neuroleptic; Physical health