title: Enhanced site-selectivity in acylation reactions with substrate-optimized catalysts on solid supports.
abstract: A concept for site selective acylation of poly-hydroxylated substrates is presented where polymer-supported catalysts are employed: catalytically active DMAP units were combined with a library of small molecule peptides attached to the solid phase with the goal to identify substrate-optimized catalysts through library screening. For selected examples, we demonstrate how the optimized catalysts can convert "their" substrate with a markedly enhanced site-selectivity, compared to only DMAP. Due to the solid support, product purification is significantly simplified, and the peptidic catalysts can be easily reused in multiple cycles while conserving its efficiency.
authors.affiliation: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany. sfkirsch@uni-wuppertal.de.
authors.forename: My Linh
authors.initials: ML
authors.lastname: Tong
authors.affiliation: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany. sfkirsch@uni-wuppertal.de.
authors.forename: Florian
authors.initials: F
authors.lastname: Huber
authors.affiliation: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany. sfkirsch@uni-wuppertal.de.
authors.forename: Estelle S
authors.initials: ES
authors.lastname: Taghuo Kaptouom
authors.affiliation: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany. sfkirsch@uni-wuppertal.de.
authors.forename: Torsten
authors.initials: T
authors.lastname: Cellnik
authors.affiliation: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany. sfkirsch@uni-wuppertal.de.
authors.forename: Stefan F
authors.identifier: http://orcid.org/0000-0003-2628-8703
authors.initials: SF
authors.lastname: Kirsch