title: Reduced White Matter Integrity in Antisocial Personality Disorder: A Diffusion Tensor Imaging Study.
abstract: Emerging neuroimaging research suggests that antisocial personality disorder (ASPD) may be linked to abnormal brain anatomy, but little is known about possible impairments of white matter microstructure in ASPD, as well as their relationship with impulsivity or risky behaviors. In this study, we systematically investigated white matter abnormalities of ASPD using diffusion tensor imaging (DTI) measures: fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD). Then, we further investigated their correlations with the scores of impulsivity or risky behaviors. ASPD patients showed decreased FA in multiple major white matter fiber bundles, which connect the fronto-parietal control network and the fronto-temporal network. We also found AD/RD deficits in some additional white matter tracts that were not detected by FA. More interestingly, several regions were found correlated with impulsivity or risky behaviors in AD and RD values, although not in FA values, including the splenium of corpus callosum, left posterior corona radiate/posterior thalamic radiate, right superior longitudinal fasciculus, and left inferior longitudinal fasciculus. These regions can be the potential biomarkers, which would be of great interest in further understanding the pathomechanism of ASPD.
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.|Department of Information Science and Engineering, Hunan First Normal University, Changsha, Hunan 410205, China.|Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA.|College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China.
authors.forename: Weixiong
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Huasheng
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Zhongxiang
authors.initials: Z
authors.lastname: Ding
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Celina
authors.initials: C
authors.lastname: Shen
authors.affiliation: Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea.
authors.forename: Seong-Whan
authors.initials: SW
authors.lastname: Lee
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China.
authors.forename: Dewen
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA.|Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea.
authors.forename: Dinggang
authors.initials: D
authors.lastname: Shen
mesh_terms: D000328:Adult; D000987:Antisocial Personality Disorder / Q000175:diagnosis*; D001931:Brain Mapping; D016022:Case-Control Studies; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009483:Neuropsychological Tests; D066127:White Matter / Q000000981:diagnostic imaging* / Q000502:physiology; D055815:Young Adult