title: Reduced E-cadherin facilitates renal cell carcinoma progression by WNT/β-catenin signaling activation.
abstract: Reduced expression of E-cadherin was observed in renal cell carcinoma (RCC). However, its potential clinical value and correlation with WNT/β-catenin signaling in RCC progression was still unclear. Immunohistochemical staining was performed in RCC tissue microarray to examine the expression status and prognosis value of E-cadherin and β-catenin. The potential role of E-cadherin in β-catenin translocation was analyzed with immunobloting assays. A significant negative correlation was observed between E-cadherin and β-catenin expression in RCC tissues. E-cadherin inhibits β-catenin translocation from membrane to cytoplasm in RCC tissues, which was an important step for WNT/β-catenin signaling. Reduced E-cadherin expression was associated with poor prognosis. More importantly, E-cadherin-/β-catenin+ was an independent detrimental factor for survival estimation of RCC patients. Reduced E-cadherin expression in RCC promoted cancer progression via WNT/β-catenin signaling pathway activation. E-cadherin/β-catenin provides a valuable prognosis marker for RCC, which may be an effective target for RCC therapy.
authors.affiliation: Emergency Department, General Hospital of Jinan Military Area, Jinan, Shandong, 250031, China.
authors.forename: Xinqi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Urology, Guizhou Provincial People's Hospital Affiliated to Guizhou Medical University, Guiyang, Guizhou, 550002, China.
authors.forename: Mingxi
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Urology, Guizhou Provincial People's Hospital Affiliated to Guizhou Medical University, Guiyang, Guizhou, 550002, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Shi
authors.affiliation: Department of Urology, Guizhou Provincial People's Hospital Affiliated to Guizhou Medical University, Guiyang, Guizhou, 550002, China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Urology, Guizhou Provincial People's Hospital Affiliated to Guizhou Medical University, Guiyang, Guizhou, 550002, China.
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Urology, Guizhou Provincial People's Hospital Affiliated to Guizhou Medical University, Guiyang, Guizhou, 550002, China.
authors.forename: Zhaolin
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Urology, Guizhou Provincial People's Hospital Affiliated to Guizhou Medical University, Guiyang, Guizhou, 550002, China.
authors.forename: Shuxiong
authors.initials: S
authors.lastname: Xu
mesh_terms: D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism*; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; D015820:Cadherins; D051153:Wnt Proteins; D051176:beta Catenin
keywords: E-cadherin; immunohistochemistry (IHC); renal cell carcinoma; β-catenin