title: Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study.
abstract: Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone formation and BMSC differentiation into osteoblasts/osteocytes, and in osteoprogenitor cell survival. The objective of this study was to examine the association of plasma SDF-1 in participants in the cardiovascular health study (CHS) with bone mineral density (BMD), body composition, and incident hip fractures. In 1536 CHS participants, SDF-1 plasma levels were significantly associated with increasing age (p < 0.01) and male gender (p = 0.04), but not with race (p = 0.63). In multivariable-adjusted models, higher SDF-1 levels were associated with lower total hip BMD (p = 0.02). However, there was no significant association of SDF-1 with hip fractures (p = 0.53). In summary, circulating plasma levels of SDF-1 are associated with increasing age and independently associated with lower total hip BMD in both men and women. These findings suggest that SDF-1 levels are linked to bone homeostasis.
authors.affiliation: Charlie Norwood Veterans Affairs Medical Center, Augusta, GA, USA.|Department of Medicine, Medical College of Georgia, Augusta University (formerly Georgia Regents University and Georgia Health Sciences University), Augusta, GA, USA.
authors.forename: Laura D
authors.initials: LD
authors.lastname: Carbone
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, WA, USA.
authors.forename: Petra
authors.initials: P
authors.lastname: Bůžková
authors.affiliation: Veterans Affairs Health Care System, Geriatric Research Education & Clinical Center, Minneapolis, MN, USA.|Veterans Affairs Health Care System, Center for Chronic Disease Outcomes Research, Minneapolis, MN, USA.|Department of Medicine, University of Minnesota, Minneapolis, MN, USA.|Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Howard A
authors.initials: HA
authors.lastname: Fink
authors.affiliation: Department of Medicine, University of California - Davis, Sacramento, CA, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Robbins
authors.affiliation: Charlie Norwood Veterans Affairs Medical Center, Augusta, GA, USA.|Department of Medicine, Medical College of Georgia, Augusta University (formerly Georgia Regents University and Georgia Health Sciences University), Augusta, GA, USA.
authors.forename: Monique
authors.initials: M
authors.lastname: Bethel
authors.affiliation: Institute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University (formerly Georgia Regents University and Georgia Health Sciences University), Augusta, GA, USA.|Department of Orthopaedic Surgery, Augusta University (formerly Georgia Regents University and Georgia Health Sciences University), Augusta, GA, USA.|Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University (formerly Georgia Regents University and Georgia Health Sciences University), Augusta, GA, USA.|Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University (formerly Georgia Regents University and Georgia Health Sciences University), Sanders Research Building, CB1119 1459 Laney-Walker Blvd., Augusta, Georgia, 30912-2000, USA.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Hamrick
authors.affiliation: Charlie Norwood Veterans Affairs Medical Center, Augusta, GA, USA. whill@augusta.edu.|Institute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University (formerly Georgia Regents University and Georgia Health Sciences University), Augusta, GA, USA. whill@augusta.edu.|Department of Orthopaedic Surgery, Augusta University (formerly Georgia Regents University and Georgia Health Sciences University), Augusta, GA, USA. whill@augusta.edu.|Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University (formerly Georgia Regents University and Georgia Health Sciences University), Sanders Research Building, CB1119 1459 Laney-Walker Blvd., Augusta, Georgia, 30912-2000, USA. whill@augusta.edu.
authors.forename: William D
authors.identifier: 0000-0002-8033-1605
authors.initials: WD
authors.lastname: Hill
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001823:Body Composition / Q000502:physiology*; D015519:Bone Density / Q000276:immunology* / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism; D002318:Cardiovascular Diseases; D054377:Chemokine CXCL12 / Q000097:blood*; D005260:Female; D006620:Hip Fractures / Q000097:blood*; D006801:Humans; D008297:Male; D010010:Osteoclasts / Q000378:metabolism; D012307:Risk Factors; D012737:Sex Factors
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12
keywords: Aging; Body composition; Cytokines; DXA; Epidemiology; Osteoporosis