title: Iodobenzene-Catalyzed Synthesis of Phenanthridinones via Oxidative C-H Amidation.
abstract: We report a novel synthesis of phenanthridinones from N-methoxybenzamides using an oxidative C-H amidation reaction at room temperature in open air with modest to excellent yields. This method demonstrated unprecedented substrate scope. In particular, it solved the long-standing challenge in the synthesis of phenanthridinones with sterically demanding substitutions.
authors.affiliation: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy , 20 Penn Street, Baltimore, Maryland 21201, United States.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Liang
authors.affiliation: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy , 20 Penn Street, Baltimore, Maryland 21201, United States.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy , 20 Penn Street, Baltimore, Maryland 21201, United States.
authors.forename: Nam
authors.identifier: 0000-0001-9147-6300
authors.initials: N
authors.lastname: Nguyen
authors.affiliation: Naval Research Laboratory , Code 6930, 4555 Overlook Avenue, Washington, D.C. 20375, United States.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Deschamps
authors.affiliation: Naval Research Laboratory , Code 6930, 4555 Overlook Avenue, Washington, D.C. 20375, United States.
authors.forename: Gregory H
authors.initials: GH
authors.lastname: Imler
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland College Park , College Park, Maryland 20740, United States.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy , 20 Penn Street, Baltimore, Maryland 21201, United States.
authors.forename: Alexander D
authors.initials: AD
authors.lastname: MacKerell
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemical Engineering, Nanjing University of Science and Technology , Nanjing, Jiangsu 210094, China.
authors.forename: Chao
authors.identifier: 0000-0002-9228-1924
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy , 20 Penn Street, Baltimore, Maryland 21201, United States.
authors.forename: Fengtian
authors.identifier: 0000-0002-4132-9887
authors.initials: F
authors.lastname: Xue
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D007462:Iodobenzenes / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D007462:Iodobenzenes; D010617:Phenanthridines; C031905:iodobenzene