title: Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts ofPterocarpus soyauxiiTaub (Papilionaceae) on Streptozotocin-induced Diabetic Rats.
abstract: OBJECTIVE
  The aim is to evaluate the hypoglycemic and antidiabetic effects of aqueous and CH2Cl2/CH3OH stem bark extracts ofPterocarpus soyauxiiTaub in normal and diabetic rats.
  
  
  METHODS
  Streptozotocin (STZ)-induced diabetic and normal adult Wistar rats were orally administered with aqueous and CH2Cl2/CH3OH plant extracts ofP. soyauxiiat various doses (38-300 mg/kg) in a single administration. In addition, STZ-induced diabetic rats received prolonged daily administration for 14 days. Glibenclamide (GB) (10 mg/kg) was used as reference treatment. In acute test, fasting blood glucose was followed for 5 h. In subacute test, body weight, food and water intakes, and blood glucose were followed weekly and serum biochemical parameters evaluated after 14 days treatment.
  
  
  RESULTS
  Acute administration of aqueous and CH2Cl2/CH3OH stem bark extracts moderately decreased fasting blood glucose compared to GB, significantly in normal rats (P< 0.05 toP< 0.01) but, as GB, not significantly in diabetic rats. Prolonged treatments in diabetic rats with aqueous and CH2Cl2/CH3OH extracts reduced blood glucose to an extent, respectively, superior or similar to GB. Moreover,P. soyauxiialso significantly (P< 0.01) reduced weight loss, and diabetes increased serum triglycerides, total cholesterol, and transaminases (alanine aminotransferase/aspartate aminotransferase) elevations.
  
  
  CONCLUSIONS
  P. soyauxiiTaub stem bark extracts have possible value for antidiabetic oral medication.
  
  
  CONCLUSIONS
  Aqueous and Dichloromethane/Methanol stem bark extracts ofPterocarpus soyauxiiTaub have potent (compared to Glibenclamide) antidiabetic effects in STZ-diabetic rats, with specific kinetics and dose-responses.Moderate hypoglycemia effects upon acuteP. soyauxiiadministration.Potent anti-hyperglycemic effects of sub-acuteP. soyauxiiadministration in STZ-diabetic rats.Potent anti-hyperlipidemic effects of sub-acuteP. soyauxiiadministration in STZ-diabetic rats.Improved hepatic and renal serum parameters after sub-acuteP. soyauxiiadministration in STZ-diabetic rats.P. soyauxiiextracts may be useful for oral treatment of diabetes and related metabolic disorders.Abbreviations Used: CH2Cl2/CH3OH: Dichloromethane/Methanol; STZ: Streptozotocin; GB: Glibenclamide; AE: Aqueous extract; OE: Organic extract; FeCl3: Iron (III) chloride; NaCl: Sodium chloride; K3Fe(CN)6: Potassium ferricyanide; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; H: Hour; BW: Body weight, W1 and W2: Weeks 1 and 2; CHOD: Cholesterol oxidase; GPO: Glycerol-3 Phosphate oxidase; PAP: Phenol + Aminophenazone.
authors.affiliation: Department of Animal Biology Organisms, Faculty of Science, University of Douala, 24157, Douala, Cameroon; Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, Cameroon; INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, France.
authors.forename: Marie Claire
authors.initials: MC
authors.lastname: Tchamadeu
authors.affiliation: Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, Cameroon.
authors.forename: Paul Désiré Djomeni
authors.initials: PD
authors.lastname: Dzeufiet
authors.affiliation: INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, France.
authors.forename: Nelly
authors.initials: N
authors.lastname: Blaes
authors.affiliation: INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Girolami
authors.affiliation: Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, Cameroon.
authors.forename: Pierre
authors.initials: P
authors.lastname: Kamtchouing
authors.affiliation: Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, Cameroon.
authors.forename: Théophile
authors.initials: T
authors.lastname: Dimo
keywords: Antihyperglycemic; Pterocarpus soyauxii Taub; diabetes mellitus; phytotherapy; rats; streptozotocin