title: [A man's role in recurrent miscarriage in a spouse].
abstract: In a review article based on the published literature and their own research, the authors examine the role of a man in recurrent miscarriage and reproductive losses in a spouse. Detailed description is presented of the negative impact of elevated levels of sperm DNA fragmentation on the course of pregnancy, especially during the first trimester, on the occurrence of recurrent miscarriage or missed abortion, on the effectiveness of assisted reproductive technology (ART) programs. The etiology and pathogenesis of damage to sperm DNA are described. Outlined are positive effects of correcting adverse lifestyle factors, the role of varicocelectomy and antioxidant therapy, and advances in ART. The review specifies the role of different male karyotype abnormalities (translocations) in the pathogenesis of pregnancy loss. The implications of urologic surgery, preimplantation genetic diagnosis in solving this problem are discussed. New treatment strategies using correction of male disorders for couples with recurrent miscarriage are offered.
authors.affiliation: Department of Andrology and Urology FSBI Scientific Center for Obstetrics, Gynecology and Perinatology n.a. Academician V.I. Kulakov of RMPH.|Department of Obstetrics, Gynecology, Perinatology and Reproductology of the Institute of Professional Education SBEI HPE First Moscow State Medical University n.a. I.M. Sechenov of RMPH.
authors.forename: S I
authors.initials: SI
authors.lastname: Gamidov
authors.affiliation: Department of Andrology and Urology FSBI Scientific Center for Obstetrics, Gynecology and Perinatology n.a. Academician V.I. Kulakov of RMPH.
authors.forename: R I
authors.initials: RI
authors.lastname: Ovchinnikov
authors.affiliation: Department of Andrology and Urology FSBI Scientific Center for Obstetrics, Gynecology and Perinatology n.a. Academician V.I. Kulakov of RMPH.|Department of Obstetrics, Gynecology, Perinatology and Reproductology of the Institute of Professional Education SBEI HPE First Moscow State Medical University n.a. I.M. Sechenov of RMPH.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Popova
authors.affiliation: Department of Reproduction FSBI Scientific Center for Obstetrics, Gynecology and Perinatology n.a. Academician V.I. Kulakov of RMPH.
authors.forename: O N
authors.initials: ON
authors.lastname: Golubeva
authors.affiliation: Department of Reproduction FSBI Scientific Center for Obstetrics, Gynecology and Perinatology n.a. Academician V.I. Kulakov of RMPH.
authors.forename: I V
authors.initials: IV
authors.lastname: Ushakova
mesh_terms: D000022:Abortion, Spontaneous / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D012735:Sexual Dysfunction, Physiological / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy
keywords: antioxidant therapy; assisted reproductive technologies; male factor infertility; normal karyotype translocation; preimplantation genetic diagnosis; recurrent miscarriage; reproductive losses; sperm DNA fragmentation; varicocele