title: Zika Virus Disease and Associated Neurologic Complications.
abstract: OBJECTIVE
  The purpose of this article is to review what is currently known about Zika virus (ZIKV) disease and associated neurologic complications.
  
  
  RESULTS
  ZIKV is a mosquito-borne or sexually transmitted flavivirus rapidly spreading throughout the Americas. While ZIKV infection is usually asymptomatic, it may cause a non-specific illness with fever, rash, myalgia, headache, and/or non-purulent conjunctivitis. Additionally, ZIKV has been associated with a number of neurologic complications including microcephaly and other birth defects, Guillain-Barré syndrome, meningoencephalitis, myelitis, and various ophthalmologic abnormalities. Treatment for ZIKV disease is supportive. Those in ZIKV endemic areas should protect themselves from mosquito bites by wearing insect repellent, wearing long-sleeved shirts and pants when outdoors, and/or using air conditioning or window screens when indoors. Furthermore, unprotected sexual intercourse should be temporarily avoided by those who recently traveled to endemic areas. Suspected ZIKV disease cases should be reported to local, state, or territorial health departments.
authors.affiliation: Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA.
authors.forename: Lindsey M
authors.initials: LM
authors.lastname: Duca
authors.affiliation: Neuro-Infectious Diseases Group, Department of Neurology and Division of Infectious Diseases, University of Colorado Denver, Aurora, CO, USA.
authors.forename: J David
authors.initials: JD
authors.lastname: Beckham
authors.affiliation: Neuro-Infectious Diseases Group, Department of Neurology and Division of Infectious Diseases, University of Colorado Denver, Aurora, CO, USA.
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Tyler
authors.affiliation: Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA. Daniel.Pastula@ucdenver.edu.|Neuro-Infectious Diseases Group, Department of Neurology and Division of Infectious Diseases, University of Colorado Denver, Aurora, CO, USA. Daniel.Pastula@ucdenver.edu.|University of Colorado School of Medicine, 12401 East 17th Avenue, Room 486, Mailstop L950, Aurora, CO, 80045, USA. Daniel.Pastula@ucdenver.edu.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Pastula
keywords: Arbovirus; Flavivirus; Guillain-Barré syndrome; Neurologic; Zika; Zika virus