title: Shortened preoperative fasting for prevention of complications associated with laparoscopic cholecystectomy: a meta-analysis.
abstract: Objective Routine fasting (12 h) is always applied before laparoscopic cholecystectomy, but prolonged preoperative fasting causes thirst, hunger, and irritability as well as dehydration, low blood glucose, insulin resistance and other adverse reactions. We assessed the safety and efficacy of a shortened preoperative fasting period in patients undergoing laparoscopic cholecystectomy. Methods We searched PubMed, Embase and Cochrane Central Register of Controlled Trials up to 20 November 2015 and selected controlled trials with a shortened fasting time before laparoscopic cholecystectomy. We assessed the results by performing a meta-analysis using a variety of outcome measures and investigated the heterogeneity by subgroup analysis. Results Eleven trials were included. Forest plots showed that a shortened fasting time reduced the operative risk and patient discomfort. A shortened fasting time also reduced postoperative nausea and vomiting as well as operative vomiting. With respect to glucose metabolism, a shortened fasting time significantly reduced abnormalities in the ratio of insulin sensitivity. The C-reactive protein concentration was also reduced by a shortened fasting time. Conclusions A shortened preoperative fasting time increases patients' postoperative comfort, improves insulin resistance, and reduces stress responses. This evidence supports the clinical application of a shortened fasting time before laparoscopic cholecystectomy.
authors.affiliation: 1 The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Duo
authors.initials: D
authors.lastname: Xu
authors.affiliation: 2 Hangzhou Normal University, Hangzhou, China.
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Zhu
authors.affiliation: 3 The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: 1 The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Liqing
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000704:Analysis of Variance; D002097:C-Reactive Protein / Q000378:metabolism; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects* / Q000523:psychology; D003681:Dehydration / Q000097:blood / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology; D005215:Fasting / Q000009:adverse effects* / Q000097:blood / Q000523:psychology; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology; D007333:Insulin Resistance; D020250:Postoperative Nausea and Vomiting / Q000097:blood / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology; D011300:Preoperative Care / Q000379:methods; D057234:Preoperative Period; D013312:Stress, Physiological; D013997:Time Factors
chemical_list: D002097:C-Reactive Protein
keywords: Shortened preoperative fasting; complications; laparoscopic cholecystectomy; meta-analysis