title: Assessment of Toxicity and Beneficiary Effects ofGarcinia pedunculataon the Hematological, Biochemical, and Histological Homeostasis in Rats.
abstract: This study was undertaken to investigate the toxicological profile of a methanolic extract ofGarcinia pedunculatafruit in rats by conducting hematological, biochemical, and histopathological examinations. Long Evans rats were divided into four groups, each with 6 animals, and were treated with three oral doses (250, 500, and 1000 mg/kg) once daily for 21 days. The extract did not cause significant changes in body and relative organ weight, percent water content, or hematological parameters at any administered doses. However, a significant dose-dependent positive effect in serum lipid profile and all atherogenic indices including the cardiac risk ratio, Castelli's risk index-2, and the atherogenic coefficient were observed. Significant increases in the levels of iron and decreases in serum alkaline phosphatase, alanine transaminase, and lactate dehydrogenase activities and the levels of serum glucose were noted when the extract was administered at the highest dose (1000 mg/kg). Histopathological examination of the target tissues further confirmed that the extract was safe and had no observed toxicological features. Our study indicates thatG. pedunculatafruit is nontoxic, has the potential to be effective against atherosclerosis, and may be used as a hepatoprotectant. The fruit extract is also beneficial to those with iron deficiency and hyperglycemia.
authors.affiliation: Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors.forename: Sudip
authors.identifier: 0000-0003-1448-2269
authors.initials: S
authors.lastname: Paul
authors.affiliation: Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors.forename: Md Yousuf
authors.initials: MY
authors.lastname: Ali
authors.affiliation: Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors.forename: Nur-E-Noushin
authors.initials: NE
authors.lastname: Rumpa
authors.affiliation: Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh; Veterinary Drug Residue Analysis Division, Institute of Food & Radiation Biology, Atomic Energy Research Establishment, Savar, Dhaka 1349, Bangladesh.
authors.forename: E M
authors.identifier: 0000-0001-5867-7004
authors.initials: EM
authors.lastname: Tanvir
authors.affiliation: Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors.forename: Md Sakib
authors.initials: MS
authors.lastname: Hossen
authors.affiliation: Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors.forename: Moumoni
authors.initials: M
authors.lastname: Saha
authors.affiliation: Wazed Miah Science Research Center, Jahangirnagar University, Dhaka 1342, Bangladesh.
authors.forename: Nikhil Chandra
authors.initials: NC
authors.lastname: Bhoumik
authors.affiliation: Human Genome Center, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
authors.forename: Siew Hua
authors.identifier: 0000-0001-6470-3651
authors.initials: SH
authors.lastname: Gan
authors.affiliation: Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh; Human Genome Center, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
authors.forename: Md Ibrahim
authors.identifier: 0000-0002-8358-0252
authors.initials: MI
authors.lastname: Khalil