title: Pulling cells out of tumours.
abstract: Tumours are highly complex and contain multiple cell types. Cancer-associated fibroblasts are now shown to have a critical role in directly leading cancer cell invasion. This intercellular interaction relies on a mechanically active cadherin-based junction, and CAF-led invasion is demonstrated to require E-cadherin in the cancer cell.
authors.affiliation: Departments of Cell Biology and Oncology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, 855 North Wolfe Street, Baltimore, Maryland 21205, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Ewald
mesh_terms: D000818:Animals; D015820:Cadherins / Q000378:metabolism; D000072645:Cancer-Associated Fibroblasts / Q000473:pathology*; D002465:Cell Movement; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000473:pathology*
chemical_list: D015820:Cadherins