title: Risk factors for visual field progression of normal-tension glaucoma in patients with myopia.
abstract: OBJECTIVE
  To identify risk factors for visual field progression of normal-tension glaucoma (NTG) in patients with myopia.
  
  
  METHODS
  Longitudinal, observational study.
  
  
  METHODS
  Fifty-one eyes of 51 NTG patients with myopia (less than -0.75D based on spherical equivalence) who had undergone visual field (VF) testing at least once per year for ≥6 years between November 2005 and December 2013.
  
  
  METHODS
  Progression was defined using event-based guided progression analysis. Risk factors were analyzed using the Cox proportional hazards model and further tested for independence in a multivariate model.
  
  
  RESULTS
  The mean observation period was 7.0 ± 1.3 years, and 16 of 51 subjects showed progression. In the univariate analysis, abnormal retinal nerve fibre layer (RNFL) colour codes (yellow or red sector) at the 11, 10, and 7 o'clock positions on optical coherence tomography showed significant associations with the VF progression (p = 0.03, 0.03, and 0.01, respectively). In the final multivariate models, the abnormal RNFL colour code of the 7 o'clock sector (inferotemporal sector) was the only significant risk factor for progression (hazard ratio = 4.07 and 4.37; 95% CI, 1.11-14.92 and 1.27-15.04; p = 0.03 and 0.02, respectively).
  
  
  CONCLUSIONS
  Inferotemporal RNFL thinning could be a risk factor for progression in NTG patients with myopia.
authors.affiliation: Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hyoung Won
authors.initials: HW
authors.lastname: Bae
authors.affiliation: Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Sang Jin
authors.initials: SJ
authors.lastname: Seo
authors.affiliation: Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Sang Yeop
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Yun Ha
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Samin
authors.initials: S
authors.lastname: Hong
authors.affiliation: Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Gong Je
authors.initials: GJ
authors.lastname: Seong
authors.affiliation: Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea.. Electronic address: kcyeye@yuhs.ac.
authors.forename: Chan Yun
authors.initials: CY
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D057066:Low Tension Glaucoma / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors; D012607:Scotoma / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult