title: Correlation between periodontal disease and oral cancer risk: A meta-analysis.
abstract: OBJECTIVE
  The purpose of this study is to investigate the correlation between periodontal disease and oral cancer risk by meta-analysis.
  
  
  METHODS
  We searched the electronic databases of PubMed and Wanfang to include the articles related to periodontal disease and oral cancer risk. The association between periodontal disease and oral cancer risk was assessed by odds ratio (OR) and its corresponding 95% confidence interval (95% CI). The publication bias was evaluated by Begg's funnel plot and Egger's line regression test. All the data analysis was done by STATA12.0 software (Stata Corporation, College Station, TX, USA).
  
  
  RESULTS
  Eleven case-control studies were included in our present meta-analysis. We found significant statistical heterogeneity was existed in our present meta-analysis (I2 = 99.8%, P < 0.05). Hence, the data were pooled by random effect model. The pooled results indicated a significant correlation between periodontal disease and oral cancer risk was found with OR = 3.21 and the 95% CI = 2.25-4.16 (P < 0.05). The Begg's funnel plot was obvious asymmetric indicating significant publication bias. Moreover, further Egger's line regression test also indicated significant publications (t = 3.35, P < 0.05).
  
  
  CONCLUSIONS
  Our present meta-analysis indicated that periodontal disease can increase the oral cancer risk by nearly 2-fold.
authors.affiliation: Department of Stomatology, Lishui People's Hospital, The 6th Affiliated Hospital of Wenzhou Medical University, Zhejiang, Lishui 323000, PR China.
authors.forename: Lili
authors.initials: L
authors.lastname: Ye
authors.affiliation: Department of Stomatology, Lishui People's Hospital, The 6th Affiliated Hospital of Wenzhou Medical University, Zhejiang, Lishui 323000, PR China.
authors.forename: Yinhua
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Stomatology, Lishui People's Hospital, The 6th Affiliated Hospital of Wenzhou Medical University, Zhejiang, Lishui 323000, PR China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Stomatology, Lishui People's Hospital, The 6th Affiliated Hospital of Wenzhou Medical University, Zhejiang, Lishui 323000, PR China.
authors.forename: HaiBiao
authors.initials: H
authors.lastname: Tao
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D004198:Disease Susceptibility; D006801:Humans; D009062:Mouth Neoplasms / Q000150:complications* / Q000453:epidemiology*; D016017:Odds Ratio; D010510:Periodontal Diseases / Q000150:complications* / Q000453:epidemiology*; D017594:Publication Bias; D012306:Risk