title: The effects of a topical lipid complex therapy on dogs with atopic dermatitis: a double blind, randomized, placebo-controlled study.
abstract: BACKGROUND
  Canine atopic dermatitis is a common clinical presentation. The skin barrier seems to play a fundamental role in the pathogenesis. Therefore a topical spot-on product containing a mixture of lipids may improve clinical signs without adverse effects if it were to improve stratum corneum barrier function.
  
  
  METHODS
  Twenty six privately owned atopic dogs of different breed, age, gender and weight were included in a double blind, randomized, placebo-controlled study.
  
  
  OBJECTIVE
  To evaluate potential clinical benefits and influence on skin barrier function of a topical lipid-containing product applied to the skin of atopic dogs.
  
  
  RESULTS
  Atopic dermatitis was diagnosed by adequate testing and the exclusion of other possible pruritic diseases. Dogs were randomly allocated to two treatment groups. A spot-on product containing different types of lipids was applied twice weekly to predisposed and affected areas. The placebo preparation contained only the excipients. The clinical effects were regularly verified with a Visual Analog Score and the Canine Atopic Dermatitis Extent and Severity Index. A medication score was calculated and barrier function was evaluated by means of transepidermal water loss and pH measurements. Twenty three dogs completed the study. There were no significant differences between the groups for any of the evaluated parameters. Adverse effects were not noted.
  
  
  CONCLUSIONS
  This study could not confirm significant clinical improvement when using the product compared to the placebo, although its use was not associated with adverse effects.
authors.affiliation: Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinaerstraße 13, 80539, Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Hobi
authors.affiliation: Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinaerstraße 13, 80539, Munich, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Klinger
authors.affiliation: Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinaerstraße 13, 80539, Munich, Germany.
authors.forename: Janine
authors.initials: J
authors.lastname: Classen
authors.affiliation: Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinaerstraße 13, 80539, Munich, Germany.
authors.forename: Ralf S
authors.initials: RS
authors.lastname: Mueller
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004311:Double-Blind Method; D005260:Female; D008055:Lipids / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D012867:Skin / Q000187:drug effects
chemical_list: D008055:Lipids