title: Marine Drugs: A Hidden Wealth and a New Epoch for Cancer Management.
abstract: BACKGROUND
  Malignant tumors are the leading cause of death in humans. Due to the tedious efforts and investigations made in the field of marine drug discovery, there is now a scientific bridge between marine and pharmaceutical sciences. However, currently only few marine drugs have been lined towards anticancer direction yet many more to are be established in future as well.
  
  
  METHODS
  This review gives an overview of present status of marine natural products MNPs both at the level of research and clinical stages. The authors haved summarized the detail information of diverse marine organisms that were reportedto be active or potentially active in cancer treatment in the last two decades. Interstingly, marine organisms are abundant producer of plenty of structurally incomparable bioactive metabolites that have unusual mode of actions and diverse biosynthetic pathways.
  
  
  RESULTS
  This review summarizes the associated anticancer properties of different classes of marine natural compounds based on their structural diversity, biological activity, and the molecular mechanisms of action. Emphasis has also be given to recent advances in clinical development of marine agents used in clinical trials.
  
  
  CONCLUSIONS
  The present review is summarising the various sources of marine chemicals and their exploration of anticancerous potential. There is justified hope for the discovery and development of new anticancer agents from the marine environment.
authors.affiliation: Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University Lucknow, Uttar Pradesh, India.|Department of Bioengineering, Faculty of Engineering, Integral University Lucknow, Uttar Pradesh, India.
authors.forename: Eram
authors.initials: E
authors.lastname: Shakeel
authors.affiliation: Department of Bioengineering, Faculty of Engineering, Integral University Lucknow, Uttar Pradesh, India.|Environmental Carcinogenesis & Proteomics Laboratory, Food, Drug & Chemical Toxicology Group, Vishvigyan Bhawan 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, India.
authors.forename: Deepika
authors.initials: D
authors.lastname: Arora
authors.affiliation: Department of Health Information Management, College of Applied Medical Sciences, Buraydah Colleges, Al-Qassim, Saudi Arabia.
authors.forename: Qazi Mohammad Sajid
authors.initials: QMS
authors.lastname: Jamal
authors.affiliation: Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University Lucknow, Uttar Pradesh, India.|Department of Bioengineering, Faculty of Engineering, Integral University Lucknow, Uttar Pradesh, India.
authors.forename: Salman
authors.initials: S
authors.lastname: Akhtar
authors.affiliation: Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University Lucknow, Uttar Pradesh, India.|Department of Bioengineering, Faculty of Engineering, Integral University Lucknow, Uttar Pradesh, India.
authors.forename: Mohd Kalim Ahmad
authors.initials: MKA
authors.lastname: Khan
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.|Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770, Australia.|Novel Global Community Educational Foundation, 7 Peterlee Place, Hebersham, NSW 2770, Australia.
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Kamal
authors.affiliation: Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University Lucknow, Uttar Pradesh, India.|Department of Bioengineering, Faculty of Engineering, Integral University Lucknow, Uttar Pradesh, India.
authors.forename: Mohd Haris
authors.initials: MH
authors.lastname: Siddiqui
authors.affiliation: Department of Biosciences, Integral University Lucknow, Uttar Pradesh, India.
authors.forename: Mohtashim
authors.initials: M
authors.lastname: Lohani
authors.affiliation: Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University Lucknow, Uttar Pradesh, India.|Department of Biosciences, Integral University Lucknow, Uttar Pradesh, India.
authors.forename: Jamal M
authors.initials: JM
authors.lastname: Arif
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D059001:Aquatic Organisms; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products
keywords: Anticancer activity; apoptosis; marine chemicals; marine environment; marine organisms; therapeutic agents.