title: Conceptual Foundations of Systems Biology Explaining Complex Cardiac Diseases.
abstract: Systems biology is an important concept that connects molecular biology and genomics with computing science, mathematics and engineering. An endeavor is made in this paper to associate basic conceptual ideas of systems biology with clinical medicine. Complex cardiac diseases are clinical phenotypes generated by integration of genetic, molecular and environmental factors. Basic concepts of systems biology like network construction, modular thinking, biological constraints (downward biological direction) and emergence (upward biological direction) could be applied to clinical medicine. Especially, in the field of cardiology, these concepts can be used to explain complex clinical cardiac phenotypes like chronic heart failure and coronary artery disease. Cardiac diseases are biological complex entities which like other biological phenomena can be explained by a systems biology approach. The above powerful biological tools of systems biology can explain robustness growth and stability during disease process from modulation to phenotype. The purpose of the present review paper is to implement systems biology strategy and incorporate some conceptual issues raised by this approach into the clinical field of complex cardiac diseases. Cardiac disease process and progression can be addressed by the holistic realistic approach of systems biology in order to define in better terms earlier diagnosis and more effective therapy.
authors.affiliation: Department of Cardiology, Aristotle University, Thessaloniki 54124, Greece. louridasg@gmail.com.
authors.forename: George E
authors.initials: GE
authors.lastname: Louridas
authors.affiliation: Department of Cardiology, Aristotle University, Thessaloniki 54124, Greece. katerina.lourida@gmail.com.
authors.forename: Katerina G
authors.initials: KG
authors.lastname: Lourida
keywords: complex diseases; constraints; coronary artery disease; emergence; heart failure; systems biology