title: Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel.
abstract: The novel property of reversible regulation of parallel type G-quadruplexes with moderate temperature changes was discovered in thermoresponsive hydrogels using a universal chiroptical spectrophotometer 1 (UCS-1). This study is the first to report the regulation of the ssDNA steric structure by using a poly(N-isopropylacrylamide) (PNIPAAm) gel.
authors.affiliation: Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. akimoto@cross.t.u-tokyo.ac.jp ryo@cross.t.u-toyo.ac.jp and Faculty of Pharmacy, Keio University, Tokyo, Japan.
authors.forename: Erika
authors.initials: E
authors.lastname: Hasuike
authors.affiliation: Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. akimoto@cross.t.u-tokyo.ac.jp ryo@cross.t.u-toyo.ac.jp.
authors.forename: Aya Mizutani
authors.initials: AM
authors.lastname: Akimoto
authors.affiliation: Research Institute for Science and Technology, Tokyo University of Science, Chiba, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Kuroda
authors.affiliation: Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. akimoto@cross.t.u-tokyo.ac.jp ryo@cross.t.u-toyo.ac.jp.
authors.forename: Ko
authors.initials: K
authors.lastname: Matsukawa
authors.affiliation: Faculty of Pharmacy, Keio University, Tokyo, Japan.
authors.forename: Yuki
authors.identifier: http://orcid.org/0000-0001-7303-4189
authors.initials: Y
authors.lastname: Hiruta
authors.affiliation: Faculty of Pharmacy, Keio University, Tokyo, Japan.
authors.forename: Hideko
authors.initials: H
authors.lastname: Kanazawa
authors.affiliation: Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. akimoto@cross.t.u-tokyo.ac.jp ryo@cross.t.u-toyo.ac.jp.
authors.forename: Ryo
authors.identifier: http://orcid.org/0000-0002-0558-2922
authors.initials: R
authors.lastname: Yoshida