title: ACR Appropriateness Criteria® Resectable Pancreatic Cancer.
abstract: Management of resectable pancreatic adenocarcinoma continues to present a challenge due to a paucity of high-quality randomized studies. Administration of adjuvant chemotherapy is widely accepted due to the high risk of systemic spread associated with pancreatic adenocarcinoma, but the role of radiation therapy is less clear. This paper reviews literature associated with resectable pancreatic cancer to include prognostic factors to aid in the selection of patients appropriate for adjuvant therapies. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.
authors.affiliation: *University of Texas Health Science Center at San Antonio, San Antonio ¶University of Texas MD Anderson Cancer Center, Houston, TX †Cancer Center of Santa Barbara, Santa Barbara §§Stanford Cancer Institute, Stanford ¶¶University of California Los Angeles, Los Angeles, CA ‡Cleveland Clinic, Cleveland, OH ***Stritch School of Medicine Loyola University Chicago, Maywood §Rush University Medical Center, Chicago, IL ∥Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, American Society of Clinical Oncology †††Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University ##Johns Hopkins University, Baltimore, MD, American College of Surgeons #Henry Ford Hospital, Detroit, MI **University of Colorado School of Medicine Anschutz Medical Campus, Aurora, CO ††Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ ‡‡University of Pennsylvania, The Chester County Hospital, West Chester, PA ∥∥Banner MD Anderson Cancer Center, Gilbert, AZ.
authors.forename: William E
authors.initials: WE
authors.lastname: Jones
authors.forename: W Waren
authors.initials: WW
authors.lastname: Suh
authors.forename: May
authors.initials: M
authors.lastname: Abdel-Wahab
authors.forename: Ross A
authors.initials: RA
authors.lastname: Abrams
authors.forename: Nilofer
authors.initials: N
authors.lastname: Azad
authors.forename: Prajnan
authors.initials: P
authors.lastname: Das
authors.forename: Jadranka
authors.initials: J
authors.lastname: Dragovic
authors.forename: Karyn A
authors.initials: KA
authors.lastname: Goodman
authors.forename: Salma K
authors.initials: SK
authors.lastname: Jabbour
authors.forename: Andre A
authors.initials: AA
authors.lastname: Konski
authors.forename: Albert C
authors.initials: AC
authors.lastname: Koong
authors.forename: Rachit
authors.initials: R
authors.lastname: Kumar
authors.forename: Percy
authors.initials: P
authors.lastname: Lee
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Pawlik
authors.forename: William
authors.initials: W
authors.lastname: Small
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Herman
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery / Q000628:therapy*; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000601:surgery / Q000628:therapy*; D018579:Patient Selection; D017410:Practice Guidelines as Topic