title: Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels.
abstract: Despite the effects of CD4+ T cell dysfunction on cognitive and behavioral impairment are well established, the effects of Th2 cytokines on the adult hippocampal neurogenesis and cognitive function in restricted CD4+ T cell receptor (TCR) repertoire model have not been fully elucidate. We found that mice with restricted CD4+ repertoire TCR showed decreased adult hippocampal neurogenesis using OT-II mice. Moreover, we demonstrated that OT-II mice showed increased Th2 cytokine levels in peripheral organs and IL-4 levels in brain. Taken together, altered Th2 cytokine levels may impact learning and memory via impaired adult neurogenesis in restricted CD4+ repertoire TCR mice.
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University , Daejeon, Republic of Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Song
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University , Daejeon, Republic of Korea.
authors.forename: Seong Gak
authors.initials: SG
authors.lastname: Jeon
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University , Daejeon, Republic of Korea.
authors.forename: Kyoung Ah
authors.initials: KA
authors.lastname: Kim
authors.affiliation: Department of Nursing, College of Nursing, Jeju National University , Jeju-si, Republic of Korea.
authors.forename: Jin-Il
authors.initials: JI
authors.lastname: Kim
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University , Daejeon, Republic of Korea.
authors.forename: Minho
authors.initials: M
authors.lastname: Moon
keywords: CD4+ T cells; OT-II mice; Th2 cytokines; adult neurogenesis; learning and memory