title: Forensic characteristics and phylogenetic analyses of the Chinese Yi population via 19 X-chromosomal STR loci.
abstract: The demographic characteristics and genetic polymorphism data of 56 Chinese nationalities or 31 administrative divisions in Chinese mainland have repeatedly been the genetic research hotspots. While most genetic studies focused on some particular Chinese populations based on autosomal or Y-chromosomal genetic markers, the forensic characteristics and phylogenetic analyses of the seventh largest Chinese population (Yi ethnicity) on the X-chromosomal genetic markers are scarce. Here, allele frequencies and forensic statistical parameters for 19 X-chromosomal short tandem repeat loci (DXS7424-DXS101, DXS6789-DXS6809, DXS7423-DXS10134, DXS10103-HPRTB-DXS10101, DXS10159-DXS10162-DXS10164, DXS10148-DXS10135-DXS8378, and DXS7132-DXS10079-DXS10074-DXS10075) of 331 Chinese Yi individuals were obtained. All 19 X-chromosomal short tandem repeat (STR) loci in females were consistent with the Hardy-Weinberg equilibrium test. A total of 214 alleles were identified with the corresponding allele frequencies spanned from 0.0019 to 0.6106. The combined PE, PDF, and PDM were 0.9999999214, 0.9999999999999999999993, and 0.9999999999998, respectively. The high combined MECKrüger, MECKishida, MECDesmarais, and MECDesmarais Duowere achieved as 0.9999999617638, 0.9999999999971, 0.9999999999971, and 0.9999999931538, respectively. The findings suggested that the panel of 19 X-STR loci is highly polymorphic and informative in the Yi ethnic population and can be considered to be a powerful tool in forensic complex kinship identification. Population differentiation analyses among 12 populations indicated that significant differences in genetic structure were observed in between the Yi ethnicity and the Chinese Uyghur as well as Kazakh, and genetic homogeneity existed in similar ethno-origin or geographic origin populations.
authors.affiliation: Department of Forensic Genetics, West China School of Preclinical and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu, Sichuan, 610041, China.
authors.forename: GuangLin
authors.initials: G
authors.lastname: He
authors.affiliation: Department of Forensic Genetics, West China School of Preclinical and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu, Sichuan, 610041, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Zou
authors.affiliation: Department of Forensic Genetics, Institute of Forensic Science, Guangzhou Public Security Bureau, Guangzhou, Guangdong, 510000, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563099, China.|Department of Forensic Medicine, Zunyi Medical University, Zunyi, Guizhou, 563099, China.
authors.forename: PengYu
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Forensic Genetics, West China School of Preclinical and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu, Sichuan, 610041, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Song
authors.affiliation: Department of Forensic Genetics, West China School of Preclinical and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu, Sichuan, 610041, China.
authors.forename: Tianzhen
authors.initials: T
authors.lastname: Gao
authors.affiliation: Department of Forensic Genetics, West China School of Preclinical and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu, Sichuan, 610041, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Liao
authors.affiliation: Department of Forensic Genetics, West China School of Preclinical and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu, Sichuan, 610041, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Forensic Genetics, West China School of Preclinical and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu, Sichuan, 610041, China. Wujin2028@163.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Wu
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D041321:Chromosomes, Human, X; D016172:DNA Fingerprinting; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D018895:Microsatellite Repeats; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
keywords: Forensic science; Genetic polymorphisms; Phylogenetic analyses; X-chromosomal STR; Yi ethnicity