title: C60Fullerene as Promising Therapeutic Agent for the Prevention and Correction of Skeletal Muscle Functioning at Ischemic Injury.
abstract: The therapeutic effect of pristine C60fullerene aqueous colloid solution (C60FAS) on the functioning of the rat soleus muscle at ischemic injury depending on the time of the general pathogenesis of muscular system and method of administration C60FAS in vivo was investigated. It was found that intravenous administration of C60FAS is the optimal for correction of speed macroparameters of contraction for ischemic muscle damage. At the same time, intramuscular administration of C60FAS shows pronounced protective effect in movements associated with the generation of maximum force responses or prolonged contractions, which increase the muscle fatigue level. Analysis of content concentration of creatine phosphokinase and lactate dehydrogenase enzymes in the blood of experimental animals indicates directly that C60FAS may be a promising therapeutic agent for the prevention and correction of ischemic-damaged skeletal muscle function.
authors.affiliation: ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, 64 Volodymyrska St., Kyiv, 01601, Ukraine.
authors.forename: D M
authors.initials: DM
authors.lastname: Nozdrenko
authors.affiliation: ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, 64 Volodymyrska St., Kyiv, 01601, Ukraine. danilozavodovskiy@gmail.com.
authors.forename: D O
authors.initials: DO
authors.lastname: Zavodovskyi
authors.affiliation: ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, 64 Volodymyrska St., Kyiv, 01601, Ukraine.
authors.forename: T Yu
authors.initials: TY
authors.lastname: Matvienko
authors.affiliation: Lesya Ukrainka Eastern European National University, 13 Volya Av., 43025, Lutsk, Ukraine.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Zay
authors.affiliation: ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, 64 Volodymyrska St., Kyiv, 01601, Ukraine.
authors.forename: K I
authors.initials: KI
authors.lastname: Bogutska
authors.affiliation: ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, 64 Volodymyrska St., Kyiv, 01601, Ukraine. prylut@ukr.net.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Prylutskyy
authors.affiliation: Institute of Chemistry and Biotechnology, Technical University of Ilmenau, 25 Weimarer St., 98693, Ilmenau, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Ritter
authors.affiliation: Institute of Chemistry and Biotechnology, Technical University of Ilmenau, 25 Weimarer St., 98693, Ilmenau, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Scharff
keywords: Biochemical analysis; C60 fullerene; Ischemia; Muscle contraction dynamics; Skeletal muscle