title: Abnormal resting-state brain activities in patients with first-episode obsessive-compulsive disorder.
abstract: OBJECTIVE
  This paper attempts to explore the brain activity of patients with obsessive-compulsive disorder (OCD) and its correlation with the disease at resting duration in patients with first-episode OCD, providing a forceful imaging basis for clinic diagnosis and pathogenesis of OCD.
  
  
  METHODS
  Twenty-six patients with first-episode OCD and 25 healthy controls (HC group; matched for age, sex, and education level) underwent functional magnetic resonance imaging (fMRI) scanning at resting state. Statistical parametric mapping 8, data processing assistant for resting-state fMRI analysis toolkit, and resting state fMRI data analysis toolkit packages were used to process the fMRI data on Matlab 2012a platform, and the difference of regional homogeneity (ReHo) values between the OCD group and HC group was detected with independent two-samplet-test. With age as a concomitant variable, the Pearson correlation analysis was adopted to study the correlation between the disease duration and ReHo value of whole brain.
  
  
  RESULTS
  Compared with HC group, the ReHo values in OCD group were decreased in brain regions, including left thalamus, right thalamus, right paracentral lobule, right postcentral gyrus, and the ReHo value was increased in the left angular gyrus region. There was a negative correlation between disease duration and ReHo value in the bilateral orbitofrontal cortex (OFC).
  
  
  CONCLUSIONS
  OCD is a multifactorial disease generally caused by abnormal activities of many brain regions at resting state. Worse brain activity of the OFC is related to the OCD duration, which provides a new insight to the pathogenesis of OCD.
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Qihui
authors.initials: Q
authors.lastname: Niu
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Song
authors.affiliation: Brainnetome Certer, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Congying
authors.initials: C
authors.lastname: Chu
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Lifang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Jingliang
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
authors.forename: Youhui
authors.initials: Y
authors.lastname: Li
keywords: OCD; functional MRI; regional homogeneity; resting state