title: Electrospinning of Bioactive Wound-Healing Nets.
abstract: The availability of appropriate dressings for treatment of wounds, in particular chronic wounds, is a task that still awaits better solutions than provided by currently applied materials. The method of electrospinning enables the fabrication of novel materials for wound dressings due to the high surface area and porosity of the electrospun meshes and the possibility to include bioactive ingredients. Recent results show that the incorporation of biologically active inorganic polyphosphate microparticles and microspheres and synergistically acting retinoids into electrospun polymer fibers yields biocompatible and antibacterial mats for potential dressings with improved wound-healing properties. The underlying principles and the mechanism of these new approaches in the therapy wounds, in particular wounds showing impaired healing, as well as for further applications in skin regeneration/repair, are summarized.
authors.affiliation: ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128, Mainz, Germany. hschroed@uni-mainz.de.|NanotecMARIN GmbH, Duesbergweg 6, 55128, Mainz, Germany. hschroed@uni-mainz.de.
authors.forename: Heinz C
authors.initials: HC
authors.lastname: Schröder
authors.affiliation: ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128, Mainz, Germany.
authors.forename: Emad
authors.initials: E
authors.lastname: Tolba
authors.affiliation: ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128, Mainz, Germany.|NanotecMARIN GmbH, Duesbergweg 6, 55128, Mainz, Germany.
authors.forename: Bärbel
authors.initials: B
authors.lastname: Diehl-Seifert
authors.affiliation: ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128, Mainz, Germany.|NanotecMARIN GmbH, Duesbergweg 6, 55128, Mainz, Germany.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wang
authors.affiliation: ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128, Mainz, Germany. wmueller@uni-mainz.de.|NanotecMARIN GmbH, Duesbergweg 6, 55128, Mainz, Germany. wmueller@uni-mainz.de.
authors.forename: Werner E G
authors.initials: WE
authors.lastname: Müller
mesh_terms: D001458:Bandages; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000494:pharmacology; D004595:Electroplating / Q000379:methods*; D006801:Humans; D008422:Materials Testing; D066330:Printing, Three-Dimensional; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations