title: Challenges and prospects of xylitol production with whole cell bio-catalysis: A review.
abstract: Xylitol, as an alternative low calorie sweetener is well accepted in formulations of various confectioneries and healthcare products. Worldwide it is industrially produced by catalytic hydrogenation of pure d-xylose solution under high temperature and pressure. Biotechnological xylitol production is a potentially attractive replacement for chemical process, as it occurs under much milder process conditions and can be based on sugar mixtures derived from low-cost industrial and agri-waste. However, microbial fermentation route of xylitol production is not so far practiced industrially. This review highlights the challenges and prospects of biotechnological xylitol production considering possible genetic modifications of fermenting microorganisms and various aspects of industrial bioprocessing and product downstreaming.
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), Biotechnology Conversion Area, Bio Fuels Division, CSIR-Indian Institute of Petroleum, Dehradun, Uttarakhand 248 005, India.
authors.forename: Diptarka
authors.initials: D
authors.lastname: Dasgupta
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), Biotechnology Conversion Area, Bio Fuels Division, CSIR-Indian Institute of Petroleum, Dehradun, Uttarakhand 248 005, India.
authors.forename: Sheetal
authors.initials: S
authors.lastname: Bandhu
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), Biotechnology Conversion Area, Bio Fuels Division, CSIR-Indian Institute of Petroleum, Dehradun, Uttarakhand 248 005, India.
authors.forename: Dilip K
authors.initials: DK
authors.lastname: Adhikari
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), Biotechnology Conversion Area, Bio Fuels Division, CSIR-Indian Institute of Petroleum, Dehradun, Uttarakhand 248 005, India. Electronic address: dghosh@iip.res.in.
authors.forename: Debashish
authors.initials: D
authors.lastname: Ghosh
mesh_terms: D055162:Biocatalysis; D001709:Biotechnology / Q000379:methods; D005285:Fermentation; D005524:Food Technology / Q000379:methods; D005818:Genetic Engineering / Q000379:methods; D007218:Industrial Microbiology / Q000379:methods; D013549:Sweetening Agents / Q000737:chemistry / Q000378:metabolism; D014993:Xylitol / Q000096:biosynthesis* / Q000737:chemistry; D014994:Xylose / Q000737:chemistry / Q000378:metabolism
chemical_list: D013549:Sweetening Agents; D014994:Xylose; D014993:Xylitol
keywords: Bioprocess; Co-factor; Gene modification; Xylitol; Yeast