title: Serum uric acid levels in non-alcoholic steatosis patients: a meta-analysis.
abstract: OBJECTIVE
  Experimental and observational studies suggest a role for increased uric acid in non-alcoholic fatty liver disease (NAFLD). This study aimed to systematically review the association between serum uric acid (SUA) levels and NAFLD. Method and Study Design: We used PubMed, and the EMBASE data-base to identify all applicable studies through November 2015. We used the weighted mean difference (WMD) to demonstrate the differences between the control and NAFLD groups in continuous data. We calculated the odds ratios (ORs) for dichotomous data using the Mantel-Haenszel method. A total of 16 observational studies were identified and used for the analysis of continuous data, and 4 studies were analyzed for dichotomous data.
  
  
  RESULTS
  The WMD was 52.3 (95% CI: 39.0, 65.5, p<0.00001). The pooled OR in observational studies was 2.08 (95% CI: 1.93-2.24, p<0.00001). The results were heterogeneous for the comparison of continuous data and homogeneous for the comparison of dichotomous data. The SUA cutoff value for the occurrence of NAFLD was 308, with a sensitivity of 94.12% [71.3-99.9] and specificity of 70.6% [44.0-89.7].
  
  
  CONCLUSIONS
  We observed a positive association between increased SUA levels and the diagnosis of NAFLD in all analyses. Our results suggest that SUA is upregulated in patients with NAFLD and might be related to the pathogenesis of NAFLD.
authors.affiliation: Department of Hepatobiliary Surgery of the First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Huang
authors.affiliation: Experimental Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Anding
authors.initials: A
authors.lastname: Liu
authors.affiliation: Department of Pathophysiology, Anhui Medical University, Hefei, China.
authors.forename: Haoshu
authors.initials: H
authors.lastname: Fang
authors.affiliation: Department of Hepatobiliary Surgery of the First Affiliated Hospital of Anhui Medical University, Hefei, China. Email: xp_geng@163.net.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Geng
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood*; D016017:Odds Ratio; D012680:Sensitivity and Specificity; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid