title: [Clinical features and prognosis in CD10(-) pre-B acute lymphoblastic leukemia].
abstract: Objective:To analyze the clinical features and prognosis of acute lymphoblastic leukemia patients with immunophenotype of CD10(-)pre-B (CD10(-) pre B-ALL) .Methods:6 adult cases with CD10(-) pre B-ALL immunophenotypes were analyzed retrospectively, related literatures were reviewed to clarify these kind of patients' clinical features and prognosis.Results:CD10(-) pre B-ALL occurred in 1.5% of ALL, 1.8% of B-ALL and 11.5% of pre B-ALL respectively. All the 6 patients were male with the median age as 33.5 years old, the median white blood cells was 101.78×10(9)/L, MLL-AF4 fusion transcripts were evident in all cases. Complete remission (CR) was achieved in 5 patients after first induction chemotherapy, 1 patient failed to respond to induction therapy, and got CR after 3 courses of chemotherapy. 2 patients underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) in CR(1), 1 patient relapsed in the short term and underwent allo-HSCT in CR(2). 1 patient was still waiting for allo-HSCT. Of the 2 patients who didn't receive transplantation, 1 died following a relapse, the other remained to be in CR.Conclusions:CD10(-) pre B-ALL was a rare but distinct subtype in adult ALL characterized by male dominance, high onset white blood cells and MLL rearrangement rate. Conventional chemotherapy produced a high response rate but more likely relapse, allo-HSCT may have the potential to improve the prognosis of these patients.
authors.affiliation: Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Gong
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: B C
authors.initials: BC
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Wei
authors.forename: C L
authors.initials: CL
authors.lastname: Zhou
authors.forename: D
authors.initials: D
authors.lastname: Lin
authors.forename: K Q
authors.initials: KQ
authors.lastname: Liu
authors.forename: S N
authors.initials: SN
authors.lastname: Wei
authors.forename: B F
authors.initials: BF
authors.lastname: Gong
authors.forename: G J
authors.initials: GJ
authors.lastname: Zhang
authors.forename: Y T
authors.initials: YT
authors.lastname: Liu
authors.forename: X L
authors.initials: XL
authors.lastname: Zhao
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: R X
authors.initials: RX
authors.lastname: Gu
authors.forename: S W
authors.initials: SW
authors.lastname: Qiu
authors.forename: Y C
authors.initials: YC
authors.lastname: Mi
authors.forename: J X
authors.initials: JX
authors.lastname: Wang
mesh_terms: D000208:Acute Disease; D000328:Adult; D002452:Cell Count; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016130:Immunophenotyping; D060828:Induction Chemotherapy; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies
keywords: Gene rearrangement, MLL; Leukemia, lymphoid; Neprilysin; Prognosis