title: Comparison of intra-articular injection of plasma rich in growth factors versus hyaluronic acid following arthroscopy in the treatment of temporomandibular dysfunction: A randomised prospective study.
abstract: OBJECTIVE
  The main objective of our study was to evaluate the effectiveness of the injection of plasma rich in platelet-derived growth factors (PRGF) versus hyaluronic acid (HA) following arthroscopic surgery in patients diagnosed with internal derangement of the temporomandibular joint (TMJ) with osteoarthritis (OA).
  
  
  METHODS
  A total of 100 patients were randomised into two study groups. Group A (n = 50) received an injection of PRGF, and Group B (n = 50) received an injection of HA. The mean age was 35.5 years (range 18-77 years), and 88% of the patients were women. The pain intensity (visual analogue scale) and the extent of maximum mouth opening before and after the procedure were statistically analysed.
  
  
  RESULTS
  Better results were observed in the group treated with PRGF, with a significant reduction in pain at 18 months, compared with HA treatment. Regarding mouth opening, an increase was observed in both groups, with no significant difference.
  
  
  CONCLUSIONS
  The injection of PRGF following arthroscopy is more effective than the injection of HA with respect to pain in patients with advanced internal derangement of the TMJ.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hospital Povisa, Vigo, Spain. Electronic address: mfernandezf@povisa.es.
authors.forename: Martín
authors.initials: M
authors.lastname: Fernández-Ferro
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hospital Povisa, Vigo, Spain.
authors.forename: Jacinto
authors.initials: J
authors.lastname: Fernández-Sanromán
authors.affiliation: School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Andrés
authors.initials: A
authors.lastname: Blanco-Carrión
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hospital Povisa, Vigo, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Costas-López
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hospital Povisa, Vigo, Spain.
authors.forename: Annahys
authors.initials: A
authors.lastname: López-Betancourt
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hospital Povisa, Vigo, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Arenaz-Bua
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hospital Povisa, Vigo, Spain.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Stavaru Marinescu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001182:Arthroscopy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010949:Plasma; D011446:Prospective Studies; D013705:Temporomandibular Joint Disorders / Q000188:drug therapy* / Q000601:surgery*; D055815:Young Adult
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D006820:Hyaluronic Acid
keywords: Arthroscopy; Hyaluronic acid; Internal derangement; Osteoarthritis; Plasma rich in platelet-derived growth factors; Temporomandibular disorder