title: The intellectual developmental disorders Mexico study: situational diagnosis, burden, genomics and intervention proposal.
abstract: This study aims to generate evidence on intellectual development disorders (IDD) in Mexico.
  IDD disease burden will be estimated with a probabilistic model, using population-based surveys. Direct and indirect costs of catastrophic expenses of families with a member with an IDD will be evaluated. Genomic characterization of IDD will include: sequencing participant exomes and performing bioinformatics analyses to identify de novo or inherited variants through trio analysis; identifying genetic variants associated with IDD, and validating randomly selected variants by polymerase chain reaction (PCR) and sequencing or real-time quantitative PCR (qPCR). Delphi surveys will be done on best practices for IDD diagnosis and management. An external evaluation will employ qualitative case studies of two social and labor inclusion programs for people with IDD.
  The results will constitute scientific evidence for the design, promotion and evaluation of public policies, which are currently absent on IDD.
authors.affiliation: Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, México.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Lazcano-Ponce
authors.affiliation: Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, México.|Departamento de Salud Mental, Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, México.
authors.forename: Gregorio
authors.initials: G
authors.lastname: Katz
authors.affiliation: Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, México.
authors.forename: Rocío
authors.initials: R
authors.lastname: Rodríguez-Valentín
authors.affiliation: Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, México.
authors.forename: Filipa de
authors.initials: F
authors.lastname: Castro
authors.affiliation: Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, México.
authors.forename: Betania
authors.initials: B
authors.lastname: Allen-Leigh
authors.affiliation: Hospital Psiquiátrico Infantil Dr. Juan N. Navarro. Ciudad de México, México.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Márquez-Caraveo
authors.affiliation: Hospital Psiquiátrico Infantil Dr. Juan N. Navarro. Ciudad de México, México.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Ramírez-García
authors.affiliation: Hospital Psiquiátrico Infantil Dr. Juan N. Navarro. Ciudad de México, México.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Arroyo-García
authors.affiliation: Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz. Ciudad de México, México.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Medina-Mora
authors.affiliation: Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill. North Carolina, USA.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Ángeles
authors.affiliation: Dirección de Indicadores y Análisis de Información Gubernamental, Instituto Nacional de Estadística y Geografía (Inegi). Ciudad de México, México.
authors.forename: José Edmundo
authors.initials: JE
authors.lastname: Urquieta-Salomón
authors.affiliation: Brain and Mind Centre, The University of Sydney. Sydney, Australia.
authors.forename: Luis
authors.initials: L
authors.lastname: Salvador-Carulla
mesh_terms: D019958:Attention Deficit and Disruptive Behavior Disorders / Q000175:diagnosis / Q000191:economics / Q000235:genetics / Q000628:therapy; D000067877:Autism Spectrum Disorder / Q000175:diagnosis / Q000191:economics / Q000235:genetics / Q000628:therapy; D002388:Catastrophic Illness / Q000191:economics; D017281:Cost of Illness; D003365:Costs and Cost Analysis; D014644:Genetic Variation; D023281:Genomics; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000191:economics / Q000235:genetics / Q000628:therapy; D008800:Mexico; D063766:Pediatric Obesity / Q000175:diagnosis / Q000191:economics / Q000235:genetics / Q000628:therapy; D011795:Surveys and Questionnaires