title: Evaluation of 18-F-fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) as a staging and monitoring tool for dogs with stage-2 splenic hemangiosarcoma - A pilot study.
abstract: Positron Emission Tomography-Computed Tomography (PET-CT) is routinely used for staging and monitoring of human cancer patients and is becoming increasingly available in veterinary medicine. In this study, 18-fluorodeoxyglucose (18FDG)-PET-CT was used in dogs with naturally occurring splenic hemangiosarcoma (HSA) to assess its utility as a staging and monitoring modality as compared to standard radiography and ultrasonography. Nine dogs with stage-2 HSA underwent 18FDG-PET-CT following splenectomy and prior to commencement of chemotherapy. Routine staging (thoracic radiography and abdominal ultrasonography) was performed prior to 18FDG-PET-CT in all dogs. When abnormalities not identified on routine tests were noted on 18FDG-PET-CT, owners were given the option to repeat a PET-CT following treatment with eBAT. A PET-CT scan was repeated on Day 21 in three dogs. Abnormalities not observed on conventional staging tools, and most consistent with malignant disease based on location, appearance, and outcome, were detected in two dogs and included a right atrial mass and a hepatic nodule, respectively. These lesions were larger and had higher metabolic activity on the second scans. 18FDG-PET-CT has potential to provide important prognostic information and influence treatment recommendations for dogs with stage-2 HSA. Additional studies will be needed to precisely define the value of this imaging tool for staging and therapy monitoring in dogs with this and other cancers.
authors.affiliation: Animal Cancer Care and Research (ACCR) Program, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America.|Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America.|Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America.
authors.forename: Antonella
authors.identifier: http://orcid.org/0000-0003-1939-0611
authors.initials: A
authors.lastname: Borgatti
authors.affiliation: Animal Cancer Care and Research (ACCR) Program, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America.|Clinical Investigation Center, College of Veterinary Medicine, St. Paul, Minnesota, United States of America.
authors.forename: Amber L
authors.initials: AL
authors.lastname: Winter
authors.affiliation: Animal Cancer Care and Research (ACCR) Program, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America.|Clinical Investigation Center, College of Veterinary Medicine, St. Paul, Minnesota, United States of America.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Stuebner
authors.affiliation: Clinical Investigation Center, College of Veterinary Medicine, St. Paul, Minnesota, United States of America.
authors.forename: Ruth
authors.initials: R
authors.lastname: Scott
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America.
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Ober
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America.
authors.forename: Kari L
authors.initials: KL
authors.lastname: Anderson
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Feeney
authors.affiliation: Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America.|Department of Therapeutic Radiology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Vallera
authors.affiliation: Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America.|Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Koopmeiners
authors.affiliation: Animal Cancer Care and Research (ACCR) Program, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America.|Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America.|Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America.
authors.forename: Jaime F
authors.initials: JF
authors.lastname: Modiano
authors.affiliation: Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America.|Center for Clinical Imaging Research (CCIR) in Diagnostic Radiology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America.
authors.forename: Jerry
authors.initials: J
authors.lastname: Froelich
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000601:surgery; D004285:Dogs; D005260:Female; D019788:Fluorodeoxyglucose F18; D006338:Heart Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary / Q000662:veterinary; D006394:Hemangiosarcoma / Q000000981:diagnostic imaging* / Q000556:secondary / Q000601:surgery / Q000662:veterinary*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary / Q000662:veterinary; D008297:Male; D009367:Neoplasm Staging / Q000379:methods / Q000662:veterinary*; D010865:Pilot Projects; D000072078:Positron Emission Tomography Computed Tomography / Q000662:veterinary*; D011379:Prognosis; D013902:Radiography, Thoracic; D019275:Radiopharmaceuticals; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery / Q000662:veterinary*; D014463:Ultrasonography
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18