title: MicroRNAs in Lung Development and Disease.
abstract: MicroRNAs (miRNAs) are small (∼22 nucleotides), non-coding RNA molecules that regulate gene expression post-transcriptionally by inhibiting target mRNAs. Research into the roles of miRNAs in lung development and disease is at the early stages. In this review, we discuss the role of miRNAs in pediatric respiratory disease, including cystic fibrosis, asthma, and bronchopulmonary dysplasia.
authors.affiliation: Departments of Surgery, Pediatrics and Child Health and Physiology and Pathophysiology, University of Manitoba, and The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Dustin
authors.initials: D
authors.lastname: Ameis
authors.affiliation: Departments of Surgery, Pediatrics and Child Health and Physiology and Pathophysiology, University of Manitoba, and The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Khoshgoo
authors.affiliation: Departments of Surgery, Pediatrics and Child Health and Physiology and Pathophysiology, University of Manitoba, and The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Iwasiow
authors.affiliation: Departments of Surgery, Pediatrics and Child Health and Physiology and Pathophysiology, University of Manitoba, and The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Phillip
authors.initials: P
authors.lastname: Snarr
authors.affiliation: Departments of Surgery, Pediatrics and Child Health and Physiology and Pathophysiology, University of Manitoba, and The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: richardkeijzer@gmail.com.
authors.forename: Richard
authors.initials: R
authors.lastname: Keijzer
mesh_terms: D000818:Animals; D001249:Asthma / Q000235:genetics; D001997:Bronchopulmonary Dysplasia / Q000235:genetics; D003550:Cystic Fibrosis / Q000235:genetics; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008168:Lung / Q000196:embryology* / Q000254:growth & development; D008171:Lung Diseases / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: MicroRNAs; asthma; bronchopulmonary dysplasia; cystic fibrosis; gene expression; lung development