title: Four-Week Consumption of Malaysian Honey Reduces Excess Weight Gain and Improves Obesity-Related Parameters in High Fat Diet Induced Obese Rats.
abstract: Many studies revealed the potential of honey consumption in controlling obesity. However, no study has been conducted using Malaysian honey. In this study, we investigated the efficacy of two local Malaysian honey types: Gelam and Acacia honey in reducing excess weight gain and other parameters related to obesity. The quality of both honey types was determined through physicochemical analysis and contents of phenolic and flavonoid. Male Sprague-Dawley rats were induced to become obese using high fat diet (HFD) prior to introduction with/without honey or orlistat for four weeks. Significant reductions in excess weight gain and adiposity index were observed in rats fed with Gelam honey compared to HFD rats. Moreover, levels of plasma glucose, triglycerides, and cholesterol, plasma leptin and resistin, liver enzymes, renal function test, and relative organ weight in Gelam and Acacia honey treated groups were reduced significantly when compared to rats fed with HFD only. Similar results were also displayed in rats treated with orlistat, but with hepatotoxicity effects. In conclusion, consumption of honey can be used to control obesity by regulating lipid metabolism and appears to be more effective than orlistat.
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia; Clinical BioPharmaceutics Research Group (CBRG), Pharmaceutical Sciences Core, UiTM, 40450 Shah Alam, Selangor, Malaysia.
authors.forename: Suhana
authors.identifier: 0000-0001-5042-5240
authors.initials: S
authors.lastname: Samat
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia; Clinical BioPharmaceutics Research Group (CBRG), Pharmaceutical Sciences Core, UiTM, 40450 Shah Alam, Selangor, Malaysia.
authors.forename: Francis
authors.initials: F
authors.lastname: Kanyan Enchang
authors.affiliation: Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia.
authors.forename: Fuzina
authors.initials: F
authors.lastname: Nor Hussein
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia; Clinical BioPharmaceutics Research Group (CBRG), Pharmaceutical Sciences Core, UiTM, 40450 Shah Alam, Selangor, Malaysia; School of Fundamental Science, Universiti Malaysia Terengganu (UMT), 21030 Kuala Nerus, Terengganu, Malaysia.
authors.forename: Wan Iryani
authors.identifier: 0000-0001-8069-2278
authors.initials: WI
authors.lastname: Wan Ismail