title: How Do Mesenchymal Stem Cells Influence or Are Influenced by Microenvironment through Extracellular Vesicles Communication?
abstract: Mesenchymal stem cells (MSCs) are widely used in cell therapy and tissue engineering thanks to their self-renewal, their multipotency, and their immunomodulatory properties that make them an attractive tool for regenerative medicine. A large part of MSCs positive effects is due to their secretion products which participate in creating a favorable microenvironment and closely relate these cells to other cell types. Extracellular vesicles (EVs) belong to cellular secretions. They are produced by cells continuously or after stimulation (e.g., calcium flux, cellular stress) and act in tissue homeostasis and intercellular communication. The understanding of the role of EVs is growing, more particularly their impact on cell migration, differentiation, or immunomodulation. EVs derived from MSCs show these interesting properties that may be considered in therapeutics, although they can have adverse effects by facilitating cancer propagation. Moreover, MSC behavior may also be influenced (proliferation, differentiation) by EVs derived from other donor cells. The aim of this mini review is to summarize the two-way communication between MSCs and other cell types, and how they can affect each other with their microenvironment through EVs. On the one hand, the manuscript presents the influence of MSC-derived EVs on diverse recipient cells and on the other hand, the effects of EVs derived from various donor cells on MSCs. The discrepancies between cancer cells and MSCs communication according to the sources of MSCs but also the tumor origins are also mentioned.
authors.affiliation: Laboratoire d'Ingénierie Moléculaire et Physiopathologie Articulaire, UMR 7365 Centre National de la Recherche Scientifique - Université de Lorraine, Biopôle de l'Université de Lorraine Vandœuvre-lès-Nancy, France.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Dostert
authors.affiliation: Laboratoire d'Ingénierie Moléculaire et Physiopathologie Articulaire, UMR 7365 Centre National de la Recherche Scientifique - Université de Lorraine, Biopôle de l'Université de Lorraine Vandœuvre-lès-Nancy, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Mesure
authors.affiliation: Laboratoire d'Ingénierie Moléculaire et Physiopathologie Articulaire, UMR 7365 Centre National de la Recherche Scientifique - Université de Lorraine, Biopôle de l'Université de LorraineVandœuvre-lès-Nancy, France; Faculté de Pharmacie, Université de LorraineVandœuvre-lès-Nancy, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Menu
authors.affiliation: Laboratoire d'Ingénierie Moléculaire et Physiopathologie Articulaire, UMR 7365 Centre National de la Recherche Scientifique - Université de Lorraine, Biopôle de l'Université de LorraineVandœuvre-lès-Nancy, France; Faculté de Pharmacie, Université de LorraineVandœuvre-lès-Nancy, France.
authors.forename: Émilie
authors.initials: É
authors.lastname: Velot
keywords: extracellular vesicles (EVs); intercellular communication; mesenchymal stem cells (MSCs); microenvironment; recipient/donor cells