title: Positron emission tomography-CT prediction of occult nodal metastasis in recurrent laryngeal cancer.
abstract: The purpose of this study was to evaluate the predictive value of positron emission tomography (PET)-CT in identifying occult nodal metastasis in clinically and radiographically N0 patients with recurrent laryngeal cancer undergoing salvage laryngectomy.
  
  
  
  Retrospective review of 46 clinically and radiographically N0 patients with recurrent laryngeal cancer who underwent a PET-CT examination before salvage laryngectomy with neck dissection from January 1, 2002, to December 31, 2014, was performed.
  
  
  
  Two patients (16.7%) had true-positive PET-CT results, whereas 10 patients (83.3%) had false-negative scans, 1 patient (2.9%) had a false-positive result and 33 patients (97.1%) had a true-negative PET-CT. The sensitivity of PET-CT was 16.7% (95% confidence interval [CI], 3.5% to 46.0%) with a specificity of 97.1% (95% CI, 83.8% to 99.9%), positive predictive value (PPV) of 66.7% (95% CI, 20.2% to 94.4%), and negative predictive value (NPV) of 76.7% (95% CI, 62.1% to 87.0%).
  
  
  
  PET-CT has poor sensitivity and NPV making PET-CT an imperfect predictor of nodal disease in recurrent laryngeal cancer. © 2017 Wiley Periodicals, Inc. Head Neck 39: 980-987, 2017.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Michigan Health Center, Ann Arbor, Michigan.
authors.forename: Andrew
authors.initials: A
authors.lastname: Rosko
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Michigan Health Center, Ann Arbor, Michigan.
authors.forename: Andrew
authors.initials: A
authors.lastname: Birkeland
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Michigan Health Center, Ann Arbor, Michigan.
authors.forename: Andrew
authors.initials: A
authors.lastname: Shuman
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Michigan Health Center, Ann Arbor, Michigan.
authors.forename: Mark
authors.initials: M
authors.lastname: Prince
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Michigan Health Center, Ann Arbor, Michigan.
authors.forename: Carol
authors.initials: C
authors.lastname: Bradford
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Michigan Health Center, Ann Arbor, Michigan.
authors.forename: Gregory
authors.initials: G
authors.lastname: Wolf
authors.affiliation: Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Francis
authors.initials: F
authors.lastname: Worden
authors.affiliation: Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Avraham
authors.initials: A
authors.lastname: Eisbruch
authors.affiliation: Department of Radiology, Division of Neuroradiology, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Ashok
authors.initials: A
authors.lastname: Srinivasan
authors.affiliation: Department of Radiology, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Ka Kit
authors.initials: KK
authors.lastname: Wong
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Michigan Health Center, Ann Arbor, Michigan.
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Spector
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000556:secondary* / Q000628:therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D016879:Salvage Therapy
keywords: laryngeal squamous cell carcinoma; occult nodal metastasis; positron emission tomography (PET)-CT; recurrent laryngeal cancer; salvage laryngectomy