title: Uric acid is associated with vascular dementia in Chinese population.
abstract: Mounting evidence suggests that oxidative stress is involved in the pathogenesis of vascular dementia (VD). Uric acid (UA) has long been implicated as a critical cause of cardiovascular disease. Nevertheless, UA was also expected to play an important role in antioxidant and neuroprotection recently. We hypothesized that UA may have a protective role against VD. The aim of this study was to investigate the link between serum UA and cognitive dysfunction in VD.
  
  
  
  There were altogether 127 VD subjects and 81 nondemented controls enrolled in our study. Serum UA, demographic, and clinical characteristics were recorded at baseline, and all participants underwent Mini-Mental State Examination (MMSE) at the beginning of the trial.
  
  
  
  The VD group showed lower MMSE scores and serum UA levels than nondemented controls and there was significant statistical difference between the two groups (p< .05). Demographic and clinical characteristics such as age, gender, education, body mass index (BMI), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), blood urea nitrogen (BUN), and serum creatinine (Scr) did not differ dramatically between groups (p> .05). In VD subjects, there was a positive correlation between serum UA and MMSE scores (r= .32,p<.05), and this correlation was independent of demographic and clinical characteristics (β = .272,p<.05).
  
  
  
  VD subjects have dramatically lower serum UA levels in comparison to nondemented controls. Lower serum UA levels are linked to cognitive dysfunction and could serve as a potential predictor for VD.
authors.affiliation: Department of Neurology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Central Laboratory Taishan Medical University Affiliated Taishan Hospital Taian Shandong Province China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Neurology Taishan Medical University Affiliated Taishan Hospital Taian Shandong Province China.
authors.forename: Ruiting
authors.initials: R
authors.lastname: Cui
authors.affiliation: Department of Neurology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.
authors.forename: Kaili
authors.initials: K
authors.lastname: Lu
authors.affiliation: Department of Neurology Taishan Medical University Affiliated Taishan Hospital Taian Shandong Province China.
authors.forename: Yunlin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.
authors.forename: Yuwu
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000368:Aged; D002681:China / Q000453:epidemiology; D060825:Cognitive Dysfunction / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology*; D015140:Dementia, Vascular / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D065840:Protective Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: oxidative stress; uric acid; vascular dementia