title: Effect of alcohol and its metabolites in lung cancer: CAPUA study.
abstract: OBJECTIVE
  Alcohol and its metabolites play an important role in carcinogenesis. This effect could be modulated by polymorphisms in genes encoding enzymes involved in the metabolism of alcohol and folate. Therefore, we analyzed the effect of alcohol consumption and ADH1B Arg48His, ADH1B Arg370Cys, ADH1C Ile349Val, ALDH2 Glu540Lys, CYP2E1 RsaI, CYP2E1 DraI, CYP2E1 TaqI and MTHFR C677T polymorphisms on the risk of developing lung cancer.
  
  
  METHODS
  We included 876 lung cancer cases and 840 controls of the CAPUA hospital-based case-control study. Genotyping was performed using the Sequenom MassArray (iPLEX GOLD) technology.
  
  
  RESULTS
  An alcohol consumption of 0.1-9.9g/day decreased lung cancer risk (ORadjusted=0.71; 95% CI 0.48-1.05), although statistical significance was not achieved. A consumption≥30g/day of alcohol and≥36PY of tobacco increases lung cancer risk (ORadjusted=26.68; 95% CI 12.69-56.10). On the other hand, a high consumption of vegetables (≥116.65g/day) and fruits (≥233.13g/day) decreases lung cancer risk with an alcohol consumption of 0.1-9.9g/day (ORadjusted=0.52; 95% CI 0.30-0.89; ORadjusted=0.58; 95% CI 0.33-1.03, respectively). An alcohol consumption of 10-29.9g/day in ADH1B 48His allele-carriers increases lung cancer risk (ORadjusted=3.32; 95% CI 1.03-10.70).
  
  
  CONCLUSIONS
  Alcohol and polymorphisms in genes involved in the metabolism of alcohol and folate are related to the onset of lung cancer.
authors.affiliation: Unidad de Epidemiología Molecular del Cáncer, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Departamento de Medicina, Universidad de Oviedo, Oviedo, Asturias, España; Consorcio de Investigación Biomédica Español en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, España.
authors.forename: Sara M
authors.initials: SM
authors.lastname: Álvarez-Avellón
authors.affiliation: Unidad de Epidemiología Molecular del Cáncer, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Departamento de Medicina, Universidad de Oviedo, Oviedo, Asturias, España; Consorcio de Investigación Biomédica Español en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, España. Electronic address: fernandezsana@uniovi.es.
authors.forename: Ana
authors.initials: A
authors.lastname: Fernández-Somoano
authors.affiliation: Consorcio de Investigación Biomédica Español en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, España; Departamento de Salud Pública, Universidad Miguel Hernández, San Juan de Alicante, Alicante, España.
authors.forename: Eva M
authors.initials: EM
authors.lastname: Navarrete-Muñoz
authors.affiliation: Consorcio de Investigación Biomédica Español en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, España; Departamento de Salud Pública, Universidad Miguel Hernández, San Juan de Alicante, Alicante, España.
authors.forename: Jesús
authors.initials: J
authors.lastname: Vioque
authors.affiliation: Unidad de Epidemiología Molecular del Cáncer, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Departamento de Medicina, Universidad de Oviedo, Oviedo, Asturias, España; Consorcio de Investigación Biomédica Español en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, España.
authors.forename: Adonina
authors.initials: A
authors.lastname: Tardón
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D005819:Genetic Markers
keywords: Acetaldehyde; Acetaldehído; Alcohol; Cáncer de pulmón; Folate; Folato; Lung cancer; Polimorfismos; Polymorphisms