title: Thyroid nodule sizes influence the diagnostic performance of TIRADS and ultrasound patterns of 2015 ATA guidelines: a multicenter retrospective study.
abstract: To evaluate the impact of thyroid nodule sizes on the diagnostic performance of thyroid imaging reporting and data system (TIRADS) and ultrasound patterns of 2015 American Thyroid Association (ATA) guidelines. Total 734 patients with 962 thyroid nodules were recruited in this retrospective study. All nodules were divided into three groups according to the maximal diameter (d < 10 mm, d = 10-20 mm and d > 20 mm). The ultrasound images were categorized based on TIRADS and ATA ultrasound patterns, respectively. A total of 931 (96.8%) and 906 (94.2%) patterns met the criteria for TIRADS and ATA ultrasound patterns. The AUC (0.849) and sensitivity (85.3%) of TIRADS were highest in d = 10-20 mm group. However, ATA had highest AUC (0.839) and specificity (89.8%) in d > 20 mm group. ATA ultrasound patterns had higher specificity (P = 0.04), while TI-RADS had higher sensitivity (P = 0.02). In nodules d > 20 mm, the specificity of ATA patterns was higher than TIRADS (P = 0.003). Our results indicated that nodule sizes may influence the diagnostic performance of TIRADS and ATA ultrasound patterns. The ATA patterns may yield higher specificity than TIRADS, especially in nodules larger than 20 mm.
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.|Department of Endocrinology, Jiangsu Province Official Hospital, Nanjing, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Gu
authors.affiliation: Department of Ultrasound, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Ye
authors.affiliation: Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
authors.forename: Shu-Hang
authors.initials: SH
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Shao
authors.affiliation: Department of Endocrinology, Huai'an First People's Hospital, Huai'an, China.
authors.forename: De-Zhen
authors.initials: DZ
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Huai'an First People's Hospital, Huai'an, China.
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Hua
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Bi-Min
authors.initials: BM
authors.lastname: Shi
authors.affiliation: Department of Endocrinology, The Central Hospital of Xuzhou Affiliated to Xuzhou Medical College, Xuzhou, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Endocrinology, WuXi People's Hospital, Wuxi, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Jiangsu Province Official Hospital, Nanjing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Wu
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods* / Q000592:standards; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013961:Thyroid Gland / Q000033:anatomy & histology* / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging*; D014463:Ultrasonography / Q000379:methods* / Q000592:standards