title: [Assessment of hematopoiesis and cytogenetics changes in interventional radiologists].
abstract: Objective:To investigate hematopoiesis and cytogenetics changes in staff of interventional radiology.Methods:A total of 121 intervention radiation workers, 245 common radiation workers and 100 medical personnel (healthy control) without exposure to radiation were enrolled in the study. The peripheral lymphocyte chromosomal aberrations and micronucleus were detected, and the result of white blood cells examination was analyzed.Results:Compared with common radiation group and healthy control group, decreases in white blood cells count, neutrophil ratio, and increase in lymphocyte ratio were observed in intervention radiation group (allP<0.05). Intervention radiation group had higher chromosome aberration rate and micronuclear rate than common radiation group and healthy control group (allP<0.05). Most common chromosome aberrations were dicentric chromosome, acentric ring, fragments and minute chromosome. Abnormal rates in chromosome aberration and micronucleus rates were increased with the rise of length of service, but no statistically significant difference was observed (P>0.05).Conclusion:Long term exposure to ionizing radiation may lead to changes in the human hematopoietic system and cause human chromosome aberration, and the severity of such injuries may be associated with the dose of ionizing radiation.
authors.affiliation: Hangzhou Prevention and Treatment Center for Occupational Diseases, Hangzhou 310014, China.
authors.forename: Qihong
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Hangzhou Prevention and Treatment Center for Occupational Diseases, Hangzhou 310014, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Yu
authors.affiliation: Hangzhou Prevention and Treatment Center for Occupational Diseases, Hangzhou 310014, China.
authors.forename: Fengyun
authors.initials: F
authors.lastname: Fu
authors.affiliation: Hangzhou Prevention and Treatment Center for Occupational Diseases, Hangzhou 310014, China.
authors.forename: Haipeng
authors.initials: H
authors.lastname: Ye
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006410:Hematopoiesis / Q000528:radiation effects*; D006801:Humans; D007958:Leukocyte Count / Q000706:statistics & numerical data*; D007962:Leukocytes / Q000473:pathology* / Q000528:radiation effects*; D008214:Lymphocytes / Q000473:pathology* / Q000528:radiation effects* / Q000648:ultrastructure*; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects*; D016273:Occupational Exposure / Q000009:adverse effects*; D000069079:Radiation Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D011839:Radiation, Ionizing; D000072177:Radiologists / Q000706:statistics & numerical data*; D013997:Time Factors