title: G1 cyclins protect pluripotency.
abstract: G1 cyclins are considered essential for DNA replication and cell division. A recent report now shows that some cells can cycle in the absence of G1 cyclins. In embryonic stem cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency.
authors.affiliation: Stanford University Medical Center, Departments of Pediatrics and Genetics, Stanford Medical School, SIM1 Building, 265 Campus Drive, Stanford, California 94305, USA.
authors.forename: Julia
authors.initials: J
authors.lastname: Arand
authors.affiliation: Stanford University Medical Center, Departments of Pediatrics and Genetics, Stanford Medical School, SIM1 Building, 265 Campus Drive, Stanford, California 94305, USA.
authors.forename: Julien
authors.initials: J
authors.lastname: Sage
mesh_terms: D000818:Animals; D002453:Cell Cycle; D056766:Cyclin G1 / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D019610:Cytoprotection; D051379:Mice; D008954:Models, Biological; D000066450:Mouse Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism*
chemical_list: D056766:Cyclin G1; D018844:Cyclin-Dependent Kinases