title: Quantitative cognitive-test characterization of reconnectable implantable fiber-optic neurointerfaces for optogenetic neurostimulation.
abstract: Cognitive tests on representative groups of freely behaving transgenic mice are shown to enable a quantitative characterization of reconnectable implantable fiber-optic neurointerfaces for optogenetic neurostimulation. A systematic analysis of such tests provides a robust quantitative measure for the cognitive effects induced by fiber-optic neurostimulation, validating the performance of fiber-optic neurointerfaces for long-term optogenetic brain stimulations and showing no statistically significant artifacts in the behavior of transgenic mice due to interface implantation.
authors.affiliation: Physics Department, International Laser Center, M. V. Lomonosov Moscow State University, Moscow, 119992, Russia.|Department of Physics and Astronomy, Texas A&M University, College Station, TX, 77843, USA.|Russian Quantum Center, ul. Novaya 100, Skolkovo, Moscow Region, 143025, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Fedotov
authors.affiliation: Russian Quantum Center, ul. Novaya 100, Skolkovo, Moscow Region, 143025, Russia.|Kurchatov Institute National Research Center, pl. akad. Kurchatova 1, Moscow, 123182, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Ivashkina
authors.affiliation: Russian Quantum Center, ul. Novaya 100, Skolkovo, Moscow Region, 143025, Russia.|Kurchatov Institute National Research Center, pl. akad. Kurchatova 1, Moscow, 123182, Russia.
authors.forename: M S
authors.initials: MS
authors.lastname: Pochechuev
authors.affiliation: Russian Quantum Center, ul. Novaya 100, Skolkovo, Moscow Region, 143025, Russia.|Kurchatov Institute National Research Center, pl. akad. Kurchatova 1, Moscow, 123182, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Roshchina
authors.affiliation: Russian Quantum Center, ul. Novaya 100, Skolkovo, Moscow Region, 143025, Russia.|Kurchatov Institute National Research Center, pl. akad. Kurchatova 1, Moscow, 123182, Russia.
authors.forename: K A
authors.initials: KA
authors.lastname: Toropova
authors.affiliation: Physics Department, International Laser Center, M. V. Lomonosov Moscow State University, Moscow, 119992, Russia.|Russian Quantum Center, ul. Novaya 100, Skolkovo, Moscow Region, 143025, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Fedotov
authors.affiliation: Kurchatov Institute National Research Center, pl. akad. Kurchatova 1, Moscow, 123182, Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Anokhin
authors.affiliation: Physics Department, International Laser Center, M. V. Lomonosov Moscow State University, Moscow, 119992, Russia.|Department of Physics and Astronomy, Texas A&M University, College Station, TX, 77843, USA.|Russian Quantum Center, ul. Novaya 100, Skolkovo, Moscow Region, 143025, Russia.|Kurchatov Institute National Research Center, pl. akad. Kurchatova 1, Moscow, 123182, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Zheltikov
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D003071:Cognition; D058542:Implantable Neurostimulators; D051379:Mice; D008822:Mice, Transgenic; D055100:Optical Fibers; D062308:Optogenetics / Q000295:instrumentation*; D019736:Prostheses and Implants
keywords: Neurophotonics; fiber-optic neurointerfaces