title: Nordic walking training attenuation of oxidative stress in association with a drop in body iron stores in elderly women.
abstract: Excess body iron accumulation and oxidative stress has been associated with ageing. Regular exercise has been shown to reduce oxidative stress and induce some changes in iron metabolism. However, the effects of exercise on both of these parameters have been poorly investigated. In our study, 35 elderly women participated in 12 weeks of Nordic walking (NW) training (three times a week). We demonstrated that the training caused a significant reduction in malondialdehyde advanced oxidation protein products-markers of oxidative stress but had no effects on paraoxonase 1 activity. These changes were associated with the decrease of blood ferritin (99.4 ± 62.7 vs. 81.4 ± 61.7 ng/ml p < 0.05). Measurement of physical fitness revealed that the training caused a significant improvement in performance and a negative correlation between the blood ferritin and endurance test was recorded (r = -0.34, p = 0.03). In addition, a significant correlation between blood ferritin and fasting glucose level was noted. The training induced a rise of HDL cholesterol from 70.8 ± 19.3-75.3 ± 21.1, p < 0.05, whereas other lipid parameters remained unchanged. In conclusion, NW training reduced body iron stores and it was associated with lower oxidative stress and better endurance.
authors.affiliation: Department of Recreation and Qualify Tourism, Gdansk University of Physical Education and Sport, Kazimierza Górskiego 1, 80-336, Gdansk, Poland. jakub.kortas@awf.gda.pl.
authors.forename: Jakub
authors.initials: J
authors.lastname: Kortas
authors.affiliation: Department of Clinical Chemistry, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kuchta
authors.affiliation: Department of Recreation and Qualify Tourism, Gdansk University of Physical Education and Sport, Kazimierza Górskiego 1, 80-336, Gdansk, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Prusik
authors.affiliation: Department of Biomedical Basis of Health, Gdansk University of Physical Education and Sport, Gdansk, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Prusik
authors.affiliation: Department of Physiology and Pharmacology, Gdansk University of Physical Education and Sport, Gdansk, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Ziemann
authors.affiliation: Department of Clinical Chemistry, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Sandra
authors.initials: S
authors.lastname: Labudda
authors.affiliation: Department of Clinical Chemistry, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Ćwiklińska
authors.affiliation: Department of Clinical Chemistry, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Wieczorek
authors.affiliation: Department of Clinical Chemistry, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Jankowski
authors.affiliation: Department of Biochemistry, Gdansk University of Physical Education and Sport, Gdansk, Poland.
authors.forename: Jedrzej
authors.initials: J
authors.lastname: Antosiewicz
mesh_terms: D062107:Advanced Oxidation Protein Products / Q000097:blood; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D005081:Exercise Therapy / Q000379:methods*; D017079:Exercise Tolerance; D005260:Female; D005293:Ferritins / Q000097:blood; D015577:Geriatric Assessment; D000073656:Healthy Aging / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood*; D008055:Lipids / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D012737:Sex Factors; D013997:Time Factors; D016896:Treatment Outcome; D016138:Walking
chemical_list: D062107:Advanced Oxidation Protein Products; D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids; D008315:Malondialdehyde; D005293:Ferritins; D007501:Iron
keywords: Exercise; Healthy lifestyle; Iron metabolism; Lipid peroxidation; Physical activity