title: Recent advances in hemophilia B therapy.
abstract: Hemophilia B is a hereditary bleeding disorder caused by the deficiency in coagulation factor IX. Understanding coagulation and the role of factor IX as well as patient population and diagnosis are all critical factors in developing treatment strategies and regimens for hemophilia B patients. Current treatment options rely on protein replacement therapy by intravenous injection, which have markedly improved patient lifespan and quality of life. However, issues with current options include lack of patient compliance due to needle-based administration, high expenses, and potential other complications (e.g., surgical procedures, inhibitor formation). As a result, these treatment options are also limited to developed countries. Recent advantages in hemophilia B treatment have focused on addressing these pain points. Emerging commercial products based on modified factor IX aim to reduce injection frequency. Exploratory research efforts have focused on novel drug delivery systems for orally administered treatment and gene therapy as a potential cure. Such alternative treatment methods are promising options for hemophilia B patients worldwide.
authors.affiliation: McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.|Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA.
authors.forename: Sarena D
authors.initials: SD
authors.lastname: Horava
authors.affiliation: McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA. peppas@che.utexas.edu.|Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA. peppas@che.utexas.edu.|Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA. peppas@che.utexas.edu.|Department of Surgery and Perioperative Care, Dell Medical School, The University of Texas at Austin, Austin, TX, USA. peppas@che.utexas.edu.|Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712-1589, USA. peppas@che.utexas.edu.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Peppas
mesh_terms: D000818:Animals; D005164:Factor IX / Q000627:therapeutic use; D002836:Hemophilia B / Q000188:drug therapy / Q000517:prevention & control / Q000628:therapy*; D006487:Hemostasis; D006801:Humans
chemical_list: D005164:Factor IX
keywords: Bioencapsulation; Coagulation; Gene therapy; Hemophilia B; Oral drug delivery