title: [High doses of trospium chloride in patients with idiopathic overactive bladder. Data of large-scale, multicenter observational program Resource].
abstract: OBJECTIVE
  Evaluation of the efficacy and safety of different doses of trospium chloride in patients with idiopathic overactive bladder.
  
  
  METHODS
  Large-scale observational program "Resource" included 669 patients with idiopathic OAB - 359 women and 310 men. At the first visit, all patients were assigned to use of trospium chloride at a standard dose of 45 mg per day. The results of treatment were evaluated during follow-up visits at 3, 6, 9 and 12 weeks. Depending on the results of examination, the dose was reduced in the presence of adverse events and increased in case of insufficient treatment effects.
  
  
  RESULTS
  After 12 weeks, 102 patients have been receiving the drug at a dose of 30 mg/day, 241 - at a dose of 45 mg/day, 257 - at a dose of 60 mg/day, and 22 - at a dose of 75 mg/day.
  
  
  CONCLUSIONS
  Individual approach to the selection of doses of trospium chloride in patients with idiopathic OAB can be quite effective and safe measure to achieve optimal clinical outcome with a good safety profile.
authors.affiliation: Department of Faculty Surgery, Urology of the Medical Faculty RNSMU n.a. N.I. Pirogov, RCRC of Gerontology.
authors.forename: G G
authors.initials: GG
authors.lastname: Krivoborodov
authors.affiliation: Department of Faculty Surgery, Urology of the Medical Faculty RNSMU n.a. N.I. Pirogov, RCRC of Gerontology.
authors.forename: E I
authors.initials: EI
authors.lastname: Tur
authors.affiliation: Department of Faculty Surgery, Urology of the Medical Faculty RNSMU n.a. N.I. Pirogov, RCRC of Gerontology.
authors.forename: N S
authors.initials: NS
authors.lastname: Efremov
authors.affiliation: Department of Faculty Surgery, Urology of the Medical Faculty RNSMU n.a. N.I. Pirogov, RCRC of Gerontology.
authors.forename: M E
authors.initials: ME
authors.lastname: Shkolnikov
mesh_terms: D001561:Benzilates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018680:Cholinergic Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009662:Nortropanes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011788:Quality of Life; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000523:psychology
chemical_list: D001561:Benzilates; D018680:Cholinergic Antagonists; D009662:Nortropanes; C003330:trospium chloride
keywords: idiopathic detrusor overactivity; overactive bladder; trospium chloride