title: Incidence of and risk factors for hospitalisations due to vascular complications: A population-based type 1 diabetes cohort (n=1316) followed into early adulthood.
abstract: OBJECTIVE
  To determine the incidence of hospitalisations and risk factors for vascular complications experienced during early adulthood in patients with childhood onset type 1 diabetes.
  
  
  METHODS
  A population-based childhood onset type 1 diabetes cohort was identified from a statewide register (1992-2012). Data linkage was used to identify a matched comparison cohort. Hospital admissions data were extracted to follow up both cohorts into early adulthood (1975-2012).
  
  
  RESULTS
  The type 1 diabetes cohort (n=1316) had a mean age of diagnosis of 9.5years, 49.5% were women and mean age at the end of follow-up was 26.3years (range 18-38). Within the type 1 diabetes cohort 32 (2.4%) were hospitalised with a vascular complication during early adulthood. Poor glycaemic control during paediatric management was associated with a significant increase in risk for ophthalmic complication with 19.4% (n=12/62) of those with a mean HbA1c >12% (108mmol/mol) diagnosed compared to 0.72% (n=5/696) of those with mean HbA1c <9% (75mmol/mol), adjusted hazard ratio 8.4 (95% CI 2.0, 34.7).
  
  
  CONCLUSIONS
  Severe vascular complications requiring hospital admission continue to be observed during early adulthood. Both women and those with poor glycaemic control are at increased risk of requiring a hospital admission for these complications during early adulthood.
authors.affiliation: Telethon Kids Institute, The University of Western Australia, Perth, Australia.
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Cooper
authors.affiliation: Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Western Australia, Australia.
authors.forename: Martin I
authors.initials: MI
authors.lastname: de Bock
authors.affiliation: Telethon Kids Institute, The University of Western Australia, Perth, Australia.
authors.forename: Kim W
authors.initials: KW
authors.lastname: Carter
authors.affiliation: Telethon Kids Institute, The University of Western Australia, Perth, Australia; The School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: de Klerk
authors.affiliation: Telethon Kids Institute, The University of Western Australia, Perth, Australia; Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Western Australia, Australia; The School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Jones
authors.affiliation: Telethon Kids Institute, The University of Western Australia, Perth, Australia; Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Western Australia, Australia; The School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia. Electronic address: Elizabeth.Davis@health.wa.gov.au.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Davis
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000628:therapy; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D003930:Diabetic Retinopathy / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D018450:Disease Progression; D006442:Glycated Hemoglobin / Q000032:analysis; D006760:Hospitalization; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control*; D007003:Hypoglycemia / Q000517:prevention & control*; D015994:Incidence; D008137:Longitudinal Studies; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D012720:Severity of Illness Index; D014904:Western Australia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Glycemic control; Hospitalization; Macrovascular complications; Microvascular complications; Type 1 diabetes mellitus