title: Circulating miRNA associated with posttraumatic stress disorder in a cohort of military combat veterans.
abstract: Posttraumatic stress disorder (PTSD) affects many returning combat veterans, but underlying biological mechanisms remain unclear. In order to compare circulating micro RNA (miRNA) of combat veterans with and without PTSD, peripheral blood from 24 subjects was collected following deployment, and isolated miRNA was sequenced. PTSD was associated with 8 differentially expressed miRNA. Pathway analysis shows that PTSD is related to the axon guidance and Wnt signaling pathways, which work together to support neuronal development through regulation of growth cones. PTSD is associated with miRNAs that regulate biological functions including neuronal activities, suggesting that they play a role in PTSD symptomatology.
authors.affiliation: National Institutes of Nursing Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: martinc2@nih.gov.
authors.forename: Christiana G
authors.initials: CG
authors.lastname: Martin
authors.affiliation: National Institutes of Nursing Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
authors.forename: Hyungsuk
authors.initials: H
authors.lastname: Kim
authors.affiliation: Yotta Biomed, Potomac, MD 20854, USA.
authors.forename: Sijung
authors.initials: S
authors.lastname: Yun
authors.affiliation: National Institutes of Nursing Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
authors.forename: Whitney
authors.initials: W
authors.lastname: Livingston
authors.affiliation: National Institutes of Nursing Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Fetta
authors.affiliation: Madigan Army Medical Center, 9040A Fitzsimmons Avenue, Tacoma, WA 98431, USA.
authors.forename: Vincent
authors.initials: V
authors.lastname: Mysliwiec
authors.affiliation: Madigan Army Medical Center, 9040A Fitzsimmons Avenue, Tacoma, WA 98431, USA.
authors.forename: Tristin
authors.initials: T
authors.lastname: Baxter
authors.affiliation: National Institutes of Nursing Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: gillj@mail.nih.gov.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Gill
mesh_terms: D000328:Adult; D000071437:Axon Guidance / Q000235:genetics; D000074166:Circulating MicroRNA / Q000235:genetics*; D015331:Cohort Studies; D003130:Combat Disorders / Q000235:genetics* / Q000523:psychology*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020439:Growth Cones / Q000502:physiology; D006801:Humans; D008297:Male; D012307:Risk Factors; D017423:Sequence Analysis, RNA; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics* / Q000523:psychology*; D014728:Veterans / Q000523:psychology*; D060449:Wnt Signaling Pathway / Q000235:genetics
chemical_list: D000074166:Circulating MicroRNA; D005819:Genetic Markers
keywords: Biomarker; Micro RNA; PTSD