title: Central Control of Feeding Behavior by the Secretin, PACAP, and Glucagon Family of Peptides.
abstract: Constituting a group of structurally related brain-gut peptides, secretin (SCT), pituitary adenylate cyclase-activating peptide (PACAP), and glucagon (GCG) family of peptide hormones exert their functionsviainteractions with the class B1 G protein-coupled receptors. In recent years, the roles of these peptides in neuroendocrine control of feeding behavior have been a specific area of research focus for development of potential therapeutic drug targets to combat obesity and metabolic disorders. As a result, some members in the family and their analogs have already been utilized as therapeutic agents in clinical application. This review aims to provide an overview of the current understanding on the important role of SCT, PACAP, and GCG family of peptides in central control of feeding behavior.
authors.affiliation: School of Biological Sciences, The University of Hong Kong , Hong Kong , China.
authors.forename: Revathi
authors.initials: R
authors.lastname: Sekar
authors.affiliation: School of Biological Sciences, The University of Hong Kong , Hong Kong , China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Biological Sciences, The University of Hong Kong , Hong Kong , China.
authors.forename: Billy Kwok Chong
authors.initials: BK
authors.lastname: Chow
keywords: PACAP; and glucagon family peptides; energy homeostasis; feeding behavior; hypothalamus; metabolic diseases; secretin