title: [Research Progress of Novel Small Molecule Drugs in the Treatment of Chronic Lymphocytic Leukemia -Review].
abstract: Chronic lymphocytic leukemia (CLL), the most frequent adult leukemia in Western population, is characterized by accumulation of mature-looking CD5+/19+/23+B cells in peripheral blood, bone marrow, and lymphatic organs. Over the last 20 years, there has been a dramatic change in therapy for CLL, the complete response rate increased from the initial <5% to the current 40%-50%, this remarkable improvement has been attributable to combination of chemoimmunotherapy agents that have contributed to the backbone of therapy for patients with CLL. Especially over the past 5 years, there has been an explosion of new active agents that provide a very effective solution for patients with recurrent/refractory disease as well as those who harbor poor cytogenetic abnormalities. This review focuses on some of the novel small molecule drugs that have either been approved or are at the forefront of clinical development in the treatment of patients with CLL, including tyrosine kinase inhibitior ibrutinib, PI3K inhibitor idelalisib, Syk inhibitor, BCL-2 inhibitor and so on.
authors.affiliation: Hematology Center, Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
authors.forename: Jing-Qiao
authors.initials: JQ
authors.lastname: Qiao
authors.affiliation: Hematology Center, Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
authors.forename: Miao
authors.initials: M
authors.lastname: He
authors.affiliation: Hematology Center, Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
authors.forename: Shu-Ting
authors.initials: ST
authors.lastname: Zhang
authors.affiliation: Hematology Center, Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China. E-mial: baihai98@tom.com.
authors.forename: Hai
authors.initials: H
authors.lastname: Bai
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D006801:Humans; D007167:Immunotherapy; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy*; D019869:Phosphatidylinositol 3-Kinases; D011505:Protein-Tyrosine Kinases; D012074:Remission Induction
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D011505:Protein-Tyrosine Kinases