title: Candidate Gene Association Studies of Anthracycline-induced Cardiotoxicity: A Systematic Review and Meta-analysis.
abstract: Anthracyclines play an important role in the management of patients with cancer but the development of anthracycline-induced cardiotoxicity (ACT) remains a significant concern for most clinicians. Recently, genetic approach has been used to identify patients at increased risk of ACT. This systematic review assessed the association between genomic markers and ACT. A systematic literature search was performed in Medline, PubMed, Cochrane Central Register of Controlled Studies, CINAHL Plus, AMED, EMBASE and HuGE Navigator from inception until May 2016. Twenty-eight studies examining the association of genetic variants and ACT were identified. These studies examined 84 different genes and 147 single nucleotide polymorphisms. Meta-analyses showed 3 risk variants significantly increased the risk for ACT; namely ABCC2 rs8187710 (pooled odds ratio: 2.20; 95% CI: 1.36-3.54), CYBA rs4673 (1.55; 1.05-2.30) and RAC2 rs13058338 (1.79; 1.27-2.52). The current evidence remains unclear on the potential role of pharmacogenomic screening prior to anthracycline therapy. Further research is needed to improve the diagnostic and prognostic role in predicting ACT.
authors.affiliation: School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 46150, Selangor, Malaysia.|Faculty of Pharmacy, Cyberjaya University College of Medical Sciences, Cyberjaya, 63000, Selangor, Malaysia.
authors.forename: Siew Lian
authors.identifier: 0000-0002-2254-9358
authors.initials: SL
authors.lastname: Leong
authors.affiliation: School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 46150, Selangor, Malaysia.|Center of Pharmaceutical Outcomes Research (CPOR), Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.|School of Pharmacy, University of Wisconsin, Madison, USA.|School of Population Health, University of Queensland, Brisbane, Australia.
authors.forename: Nathorn
authors.initials: N
authors.lastname: Chaiyakunapruk
authors.affiliation: School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 46150, Selangor, Malaysia. shaun.lee@monash.edu.
authors.forename: Shaun Wen Huey
authors.identifier: 0000-0001-7361-6576
authors.initials: SW
authors.lastname: Lee
mesh_terms: D018943:Anthracyclines / Q000009:adverse effects*; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D066126:Cardiotoxicity / Q000453:epidemiology*; D056726:Genetic Association Studies; D006801:Humans; D000089762:Multidrug Resistance-Associated Protein 2; D000071185:Pharmacogenomic Testing; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C000715087:ABCC2 protein, human; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000089762:Multidrug Resistance-Associated Protein 2