title: [Clinical application value of prognostic nutritional index for predicting survival in patients with advanced non-small cell lung cancer].
abstract: Objective:To explore the clinical application value of prognostic nutritional index(PNI) for predicting overall survival(OS) in patients with advanced non-small cell lung cancer (NSCLC).Methods:123 patients with histologically confirmed non-small cell lung cancer were enrolled in this study, and their clinical and laboratory data were reviewed. The PNI was calculated as 10×serum albumin value+ 5×total lymphocyte countin peripheral blood.Univariate and multivariate analyses were used to identify the potential prognostic factors for advanced NSCLC.Results:PNI of the 123 NSCLC patients was 46.24±6.56. PNI was significantly associated with age, weight loss and pleural effusion (P<0.05). However, it showed no relationship with sex, smoking, hemoptysis, chest pain, dyspnea, histological type, clinical stage, and administration of chemotherapy (P>0.05). The median OS of the 123 patients was 19.5 months. The median OS in the higher PNI group (PNI≥46.24) and lower PNI group(PNI<46.24) were 25.2 months and 16.4 months, respectively.The 1-year survival rates were 80.6% and 63.9%, and 2-year survival rates were 54.8% and 19.6%, respectively (P<0.01). Univariate analysis showed that PNI, age, dyspnea, and weight loss were related to the OS of the advanced NSCLC patients (P<0.05). Multivariate analysis identified PNI as an independent prognostic factor for OS of advanced NSCLC (P<0.001).Conclusion:PNI can be easily calculated, and may be used as a relatively new prognostic indicator for advanced NSCLC in clinical practice.
authors.affiliation: Taishan Medical University, Tai'an 271000, China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Xu
authors.affiliation: Department of Respiratory Medicine, Qianfoshan Hospital of Shandong Province, Shandong University, Jinan 250014, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Kang
authors.affiliation: Department of Respiratory Medicine, Qianfoshan Hospital of Shandong Province, Shandong University, Jinan 250014, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Medicine, Qianfoshan Hospital of Shandong Province, Shandong University, Jinan 250014, China.
authors.forename: F F
authors.initials: FF
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, Qianfoshan Hospital of Shandong Province, Shandong University, Jinan 250014, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Song
authors.affiliation: Department of Respiratory Medicine, Qianfoshan Hospital of Shandong Province, Shandong University, Jinan 250014, China.
authors.forename: C Q
authors.initials: CQ
authors.lastname: Zhang
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000401:mortality*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000401:mortality*; D018655:Lymphocyte Count; D008297:Male; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D015596:Nutrition Assessment; D009752:Nutritional Status; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis; D015996:Survival Rate
chemical_list: D012709:Serum Albumin
keywords: Carcinoma, non-small-cell lung; Prognosis; Prognostic nutritional index