title: The treatment of vulval lichen sclerosus in prepubertal girls: a critically appraised topic.
abstract: Lichen sclerosus is one of the dermatoses that specifically affects the anogenital skin. It has peaks of incidence in prepubertal girls and postmenopausal women. The objective of this critical appraisal was to review systematically the evidence for efficacy and safety of different treatments. There are no randomized controlled studies of treatment in prepubertal girls and most studies are small case series or case reports. There is little focus on quality of life.
authors.affiliation: St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Mashayekhi
authors.affiliation: St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, U.K.
authors.forename: C
authors.initials: C
authors.lastname: Flohr
authors.affiliation: St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, U.K.
authors.forename: F M
authors.initials: FM
authors.lastname: Lewis
mesh_terms: D000287:Administration, Topical; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D018459:Lichen Sclerosus et Atrophicus / Q000188:drug therapy*; D009824:Ointments; D013256:Steroids / Q000008:administration & dosage* / Q000009:adverse effects; D016559:Tacrolimus / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome; D014845:Vulvar Diseases / Q000188:drug therapy*
chemical_list: D007166:Immunosuppressive Agents; D009824:Ointments; D013256:Steroids; D016559:Tacrolimus