title: Evaluation of oxidative stress in chronic periodontitis patients following systemic antioxidant supplementation: A clinical and biochemical study.
abstract: BACKGROUND
  Oxidative stress is associated with the pathogenesis of many systemic diseases including chronic periodontitis. Periodontal pathogen activated neutrophils liberate the reactive oxygen species (ROS), which causes the destruction of periodontal tissues. Antioxidants modulate the ROS production and inhibit the tissue destruction.
  
  
  OBJECTIVE
  We aimed to evaluate the oxidative stress marker malondialdehyde (MDA) in chronic periodontitis patients following scaling and root planing (SRP) after systemic lycopene supplementation.
  
  
  METHODS
  This was an interventional single arm study. Twenty systemically healthy patients with chronic periodontitis were recruited. Clinical parameters modified gingival index, probing depth, clinical attachment loss were recorded, and serum MDA levels were assessed by thiobarbituric acid reactive substances assay. Patients were supplemented with 8 mg lycopene daily for 2 months following SRP treatment. All the parameters were assessed at pretreatment and 2 months and 6 months posttreatment.
  
  
  RESULTS
  From pretreatment to posttreatment at 2 months, the mean values of all parameters were reduced. While from 2 to 6 months when lycopene was not administered, an increase in the mean values of all the parameters was observed; however, these values were still below baseline values.
  
  
  CONCLUSIONS
  There was a reduction in oxidative stress and improvement in clinical parameters following systemic antioxidant therapy along with SRP, which was maintained up to 4 months after discontinuation of lycopene treatment.
authors.affiliation: Department of Periodontology, Panineeya Mahavidyalaya Institute of Dental Sciences, Hyderabad, Telangana, India.
authors.forename: Manasa
authors.initials: M
authors.lastname: Ambati
authors.affiliation: Department of Periodontology, Panineeya Mahavidyalaya Institute of Dental Sciences, Hyderabad, Telangana, India.
authors.forename: Koduganti Rekha
authors.initials: KR
authors.lastname: Rani
authors.affiliation: Department of Periodontology, Panineeya Mahavidyalaya Institute of Dental Sciences, Hyderabad, Telangana, India.
authors.forename: Panthula Veerendranath
authors.initials: PV
authors.lastname: Reddy
authors.affiliation: Department of Periodontology, Panineeya Mahavidyalaya Institute of Dental Sciences, Hyderabad, Telangana, India.
authors.forename: Jammula
authors.initials: J
authors.lastname: Suryaprasanna
authors.affiliation: Department of Periodontology, Panineeya Mahavidyalaya Institute of Dental Sciences, Hyderabad, Telangana, India.
authors.forename: Rajashree
authors.initials: R
authors.lastname: Dasari
authors.affiliation: Department of Periodontology, Panineeya Mahavidyalaya Institute of Dental Sciences, Hyderabad, Telangana, India.
authors.forename: Himabindu
authors.initials: H
authors.lastname: Gireddy
keywords: Antioxidant therapy; chronic periodontitis; malondialdehyde; oxidative stress