title: Designing Hybrid Antibiotic Peptide Conjugates To Cross Bacterial Membranes.
abstract: We design hybrid antibiotic peptide conjugates that can permeate membranes. Integration of multiple components with different functions into a single molecule is often problematic, due to competing chemical requirements for different functions and to mutual interference. By examining the structure of antimicrobial peptides (AMPs), we show that it is possible to design and synthesize membrane active antibiotic peptide conjugates (MAAPCs) that synergistically combine multiple forms of antimicrobial activity, resulting in unusually strong activity against persistent bacterial strains.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Deshayes
authors.forename: Wujing
authors.initials: W
authors.lastname: Xian
authors.affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco , 555 Mission Bay Boulevard South, San Francisco, California 94158, United States.
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Schmidt
authors.forename: Shadi
authors.initials: S
authors.lastname: Kordbacheh
authors.forename: Juelline
authors.initials: J
authors.lastname: Lieng
authors.forename: Jennifer
authors.initials: J
authors.lastname: Wang
authors.forename: Sandra
authors.initials: S
authors.lastname: Zarmer
authors.forename: Samantha St
authors.initials: SS
authors.lastname: Germain
authors.forename: Laura
authors.initials: L
authors.lastname: Voyen
authors.forename: Julia
authors.initials: J
authors.lastname: Thulin
authors.forename: Gerard C L
authors.initials: GC
authors.lastname: Wong
authors.forename: Andrea M
authors.identifier: 0000-0003-2355-6258
authors.initials: AM
authors.lastname: Kasko
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D004927:Escherichia coli Infections / Q000188:drug therapy; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D010539:Permeability; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides