title: General Characteristics and Cytotoxic Effects of Nano-Poly (Butyl Cyanoacrylate) Containing Carboplatin on Ovarian Cancer Cells
abstract: The initial response to treatment and subsequent development of resistance to carboplatin are very important
  challenges. Use of nano drug delivery is a new method to replace standard chemotherapy. In this research, both
  non-PEGylated and PEGylated nanoparticles (NPs) were prepared by mini-emulsion polymerization of poly (butyl
  cyanoacrylate) (PBCA) NPs. Characteristics such as size, polydispersity index (PDI), zeta potential, drug release,
  and stability were examined. In addition, infrared spectroscopy was used for description of the produced NPs. Then,
  cytotoxicity effects of both formulations were studied on the A2780CIS ovarian cancer cell line with incubation for
  24, 48, and 72h. Examination of characteristics of loaded carboplatin on the PBCA NPs under suitable laboratory
  conditions showed a positive effect of PEG on their properties. Cytotoxicity studies demonstrated greater toxicity with
  both formulations of nano-drugs than the free drug. The results indicated that PBCA NPs can be considered as suitable
  candidates for nano-drugs in chemotherapy.
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Islamic Azad University, Shahreza Branch, Shahreza, Iran. Email:ebrahimifar67@gmail.com
authors.forename: Leila
authors.initials: L
authors.lastname: Kanaani
authors.forename: Meysam
authors.initials: M
authors.lastname: Ebrahimi Far
authors.forename: S Maryam
authors.initials: SM
authors.lastname: Kazemi
authors.forename: Edris
authors.initials: E
authors.lastname: Choupani
authors.forename: Maral
authors.initials: M
authors.lastname: Mazloumi Tabrizi
authors.forename: Hasan
authors.initials: H
authors.lastname: Ebrahimi Shahmabadi
authors.forename: Azim
authors.initials: A
authors.lastname: Akbarzadeh Khiyavi
keywords: Ovarian cancer; carboplatin; poly (butyl Cyanoacrylate) nanoparticle; nano-drug delivery