title: COMPARISON BETWEEN SEDATION AND GENERAL ANESTHESIA FOR HIGH RESOLUTION COMPUTED TOMOGRAPHIC CHARACTERIZATION OF CANINE IDIOPATHIC PULMONARY FIBROSIS IN WEST HIGHLAND WHITE TERRIERS.
abstract: Canine idiopathic pulmonary fibrosis is a progressive interstitial lung disease mainly affecting West Highland white terriers. Thoracic high-resolution computed tomographic (T-HRCT) findings for Canine idiopathic pulmonary fibrosis acquired under general anesthesia have been described previously. However, the use of general anesthesia may be contraindicated for some affected dogs. Sedation may allow improved speed and safety, but it is unknown whether sedation would yield similar results in identification and grading of Canine idiopathic pulmonary fibrosis lesions. The aim of this prospective, observational, method-comparison, case-control study was to compare findings from T-HRCT images acquired under sedation versus general anesthesia for West Highland white terriers affected with Canine idiopathic pulmonary fibrosis (n = 11) and age-matched controls (n = 9), using the glossary of terms of the Fleischner Society and a scoring system. Ground-glass opacity was identified in all affected West Highland white terriers for both sedation and general anesthesia acquisitions, although the Ground-glass opacity extent varied significantly between the two acquisitions (P < 0.001). Ground-glass opacity was the sole lesion observed in control dogs (n = 6), but was less extensive compared with affected West Highland white terriers. Identification and grading of a mosaic attenuation pattern differed significantly between acquisitions (P < 0.001). Identification of lesions such as consolidations, nodules, parenchymal and subpleural bands, bronchial wall thickening, and bronchiectasis did not differ between acquisitions. The present study demonstrated that T-HRCT obtained under sedation may provide different information than T-HRCT obtained under general anesthesia for identification and grading of some Canine idiopathic pulmonary fibrosis lesions, but not all of them. These differences should be taken into consideration when general anesthesia is contraindicated and sedation is necessary for evaluating West Highland white terriers with Canine idiopathic pulmonary fibrosis.
authors.affiliation: Department of Clinical Sciences, Fundamental and Applied Research for Animals & Health (FARAH), University of Liège, 4000, Liège, Belgium.
authors.forename: Elodie
authors.initials: E
authors.lastname: Roels
authors.affiliation: Department of Radiology, Christian Hospital Center Liège, Belgium.
authors.forename: Thierry
authors.initials: T
authors.lastname: Couvreur
authors.affiliation: Department of Biostatistics and Bioinformatics applied to Veterinary Sciences, Faculty of Veterinary Medicine, Fundamental and Applied Research for Animals & Health (FARAH), University of Liège, 4000, Liège, Belgium.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Farnir
authors.affiliation: Department of Clinical Sciences, Fundamental and Applied Research for Animals & Health (FARAH), University of Liège, 4000, Liège, Belgium.
authors.forename: Cécile
authors.initials: C
authors.lastname: Clercx
authors.affiliation: Department of Radiology, Faculty of Medicine, University Clinic Leuven, 3000, Leuven, Belgium.
authors.forename: Johny
authors.initials: J
authors.lastname: Verschakelen
authors.affiliation: Department of Clinical Sciences, Fundamental and Applied Research for Animals & Health (FARAH), University of Liège, 4000, Liège, Belgium.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Bolen
mesh_terms: D000768:Anesthesia, General / Q000662:veterinary*; D000818:Animals; D001530:Belgium; D016022:Case-Control Studies; D016292:Procedural Sedation / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging*; D004285:Dogs; D005260:Female; D054990:Idiopathic Pulmonary Fibrosis / Q000000981:diagnostic imaging / Q000662:veterinary*; D008297:Male; D011446:Prospective Studies; D013045:Species Specificity; D014057:Tomography, X-Ray Computed / Q000662:veterinary
keywords: bronchial disease; consolidation; ground glass opacity; mosaic attenuation pattern