title: Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases.
abstract: Advanced glycation end products (AGEs) and their receptor have been implicated in the progressions of many intractable diseases, such as diabetes and atherosclerosis, and are also critical for pathologic changes in chronic degenerative diseases, such as Alzheimer's disease, Parkinson's disease, and alcoholic brain damage. Recently activated macrophages were found to be a source of AGEs, and the most abundant form of AGEs, AGE-albumin excreted by macrophages has been implicated in these diseases and to act through common pathways. AGEs inhibition has been shown to prevent the pathogenesis of AGEs-related diseases in human, and therapeutic advances have resulted in several agents that prevent their adverse effects. Recently, anti-inflammatory molecules that inhibit AGEs have been shown to be good candidates for ameliorating diabetic complications as well as degenerative diseases. This review was undertaken to present, discuss, and clarify current understanding regarding AGEs formation in association with macrophages, different diseases, therapeutic and diagnostic strategy and links with RAGE inhibition.
authors.affiliation: Center for Genomics and Proteomics, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Republic of Korea; Department of Anatomy and Cell Biology, Gachon University Graduate School of Medicine, Incheon 406-799, Republic of Korea.
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Byun
authors.affiliation: Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon 305-811, Republic of Korea.
authors.forename: YongCheol
authors.initials: Y
authors.lastname: Yoo
authors.affiliation: Department of Anatomy and Cell Biology, Gachon University Graduate School of Medicine, Incheon 406-799, Republic of Korea.
authors.forename: Myeongjoo
authors.initials: M
authors.lastname: Son
authors.affiliation: Center for Genomics and Proteomics, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Republic of Korea.
authors.forename: Jaesuk
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Anatomy and Cell Biology, Gachon University Graduate School of Medicine, Incheon 406-799, Republic of Korea.
authors.forename: Goo-Bo
authors.initials: GB
authors.lastname: Jeong
authors.affiliation: Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon 305-811, Republic of Korea. Electronic address: ympark@kbsi.re.kr.
authors.forename: Young Mok
authors.initials: YM
authors.lastname: Park
authors.affiliation: Department of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address: Salekdeh@royaninstitute.org.
authors.forename: Ghasem Hosseini
authors.initials: GH
authors.lastname: Salekdeh
authors.affiliation: Center for Genomics and Proteomics, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Republic of Korea; Department of Anatomy and Cell Biology, Gachon University Graduate School of Medicine, Incheon 406-799, Republic of Korea. Electronic address: bhlee@gachon.ac.kr.
authors.forename: Bonghee
authors.initials: B
authors.lastname: Lee
mesh_terms: D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products
keywords: Advanced glycation end products (AGEs); Degenerative diseases; Inflammation; Macrophage; Receptor for AGEs (RAGE)