title: Endometriosis and Ovarian Cancer: an Integrative Review (Endometriosis and Ovarian Cancer)
abstract: Despite being initially considered a benign disease, it is widely thought nowadays that endometriosis and especially
  ovarian endometriomas are neoplastic conditions with the potential to become malignant. This review was conducted to
  summarize, in a concise and systematic manner, the available scientific data relating endometriosis to ovarian cancer,
  published in the past five years. After reading abstracts and applying our predefined inclusion and exclusion criteria,
  a final list of 11 scientific papers was obtained and subjected to review. Endometriosis is associated with an increased
  risk of developing epithelial ovarian cancer (EOC), mainly of endometrioid and clear cell subtypes. This might be
  by virtue of the high estrogen concentration with the disease, which leads to malignant proliferation of endometriotic
  cysts, or be due to mutations in the ARID1A gene and consequent loss of BAF250a expression. The iron produced in
  the fluid of endometriotic cysts promotes oxidative stress, which in turn may cause genetic mutations and malignant
  progression of ovarian cysts.
authors.affiliation: University of Fortaleza (UNIFOR) Medical School. 1321 Washington Soares Ave, Edson Queiroz, Fortaleza - CE, Unit S, Hall S1. Zip code: 60811-905. E-mail: alineveras@unifor.br
authors.forename: Aline Veras Morais
authors.initials: AV
authors.lastname: Brilhante
authors.forename: Kathiane Lustosa
authors.initials: KL
authors.lastname: Augusto
authors.forename: Manuela Cavalcante
authors.initials: MC
authors.lastname: Portela
authors.forename: Luiz Carlos Gabriele
authors.initials: LC
authors.lastname: Sucupira
authors.forename: Luiz Adriano Freitas
authors.initials: LA
authors.lastname: Oliveira
authors.forename: Ana Juariana Magalhães Veríssimo
authors.initials: AJ
authors.lastname: Pouchaim
authors.forename: Lívia Rocha Mesquita
authors.initials: LR
authors.lastname: Nóbrega
authors.forename: Thaís Fontes de
authors.initials: TF
authors.lastname: Magalhães
authors.forename: Leonardo Robson Pinheiro
authors.initials: LR
authors.lastname: Sobreira
keywords: Endometriosis; neoplasm; ovarian cancer; review