title: Role of the pretreatment18F-fluorodeoxyglucose positron emission tomography maximal standardized uptake value in predicting outcomes of colon liver metastases and that value's association with Beclin-1 expression.
abstract: The current study sought to evaluate the predictive and prognostic performance of the maximum standardized uptake value (SUVmax) prior to treatment in 43 patients with colon cancer and unresectable liver metastases. Patients with colon cancer who underwent18F-FDG-PET/computed tomography (CT) scans for staging before the start of first-line 5-fluorouracil-based chemotherapy were retrospectively analyzed. Expression of Beclin-1 in cancer cells was evaluated in primary tumors using immunohistochemical staining. The pretreatment SUVmaxfor liver metastases was not able to predict progression-free survival but was significantly associated with poorer overall survival, with a hazard ratio of 2.05 (95 % CI, 1.016-4.155). Moreover, a negative correlation was noted between SUVmaxand expression of a marker of autophagy - Beclin-1 (rho = -0.42, p = 0.006). This suggests that the pretreatment SUVmaxin18F-FDG PET/CT is a useful tool to help predict survival outcome in patients with colon cancer and unresectable liver metastases and may significantly distinguish between patients with low and high levels of Beclin-1 expression (AUC = 0.809, 95% CI: 0.670-0.948, p = 0.001).
authors.affiliation: Clinic of Medical Oncology, UMHAT "St. Marina".|Department of Propedeutics of Internal Diseases, Medical University of Varna.
authors.forename: Eleonora G
authors.initials: EG
authors.lastname: Dimitrova
authors.affiliation: Department of Nuclear Medicine, UMHAT "St. Marina".
authors.forename: Borislav G
authors.initials: BG
authors.lastname: Chaushev
authors.affiliation: Clinic of Medical Oncology, UMHAT "St. Marina".|Department of Propedeutics of Internal Diseases, Medical University of Varna.
authors.forename: Nikolay V
authors.initials: NV
authors.lastname: Conev
authors.affiliation: Department of Propedeutics of Internal Diseases, Medical University of Varna.
authors.forename: Javor K
authors.initials: JK
authors.lastname: Kashlov
authors.affiliation: Clinic of Surgery, UMHAT "St. Marina".|Department of General and Operative Surgery, Medical University of Varna.
authors.forename: Aleksandar K
authors.initials: AK
authors.lastname: Zlatarov
authors.affiliation: Clinic of Surgery, UMHAT "St. Marina".|Department of General and Operative Surgery, Medical University of Varna.
authors.forename: Dilyan P
authors.initials: DP
authors.lastname: Petrov
authors.affiliation: Centre of Clinical Pathology, UMHAT "St. Marina".
authors.forename: Hristo B
authors.initials: HB
authors.lastname: Popov
authors.affiliation: Centre of Clinical Pathology, UMHAT "St. Marina".
authors.forename: Nadezhda T
authors.initials: NT
authors.lastname: Stefanova
authors.affiliation: Department of Nuclear Medicine, UMHAT "St. Marina".
authors.forename: Anelia D
authors.initials: AD
authors.lastname: Klisarova
authors.affiliation: Division of Pathophysiology, Medical University of Varna.
authors.forename: Kameliya Z
authors.initials: KZ
authors.lastname: Bratoeva
authors.affiliation: Clinic of Medical Oncology, UMHAT "St. Marina".|Department of Propedeutics of Internal Diseases, Medical University of Varna.
authors.forename: Ivan S
authors.initials: IS
authors.lastname: Donev
mesh_terms: D000328:Adult; D000368:Aged; D000071186:Beclin-1 / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000032:analysis*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000401:mortality / Q000556:secondary; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D000071186:Beclin-1; D019788:Fluorodeoxyglucose F18
keywords: Beclin-1; Maximum standardized uptake value (SUVmax); colon cancer