title: [Specific microRNA expression profiles of lung adenocarcinoma in Xuanwei region and bioinformatic analysis for predicting their target genes and related signaling pathways].
abstract: OBJECTIVE
  To identify differentially expressed microRNAs (miRNAs) related to lung adenocarcinoma in Xuanwei region and predict their target genes and related signaling pathways based on bioinformatic analysis.
  
  
  METHODS
  High-throughput microarray assay was performed to detect miRNA expression profiles in 34 paired human lung adenocarcinoma and adjacent normal tissues (including 24 cases in Xuanwei region and 10 in other regions). Gene ontology and KEGG pathway analyses were used to predict the target genes and the regulatory signaling pathways.
  
  
  RESULTS
  Thirty-four miRNAs were differentially expressed in lung adenocarcinoma tissues in cases in Xuanwei region as compared with cases in other regions, including 23 upregulated and 11 downregulated miRNAs. The predicted target genes included GF, RTK, SOS, IRS1, BCAP, CYTOKINSR, ECM, ITGB, FAK and Gbeta;Y involving the PI3K/Alt, WNT and MAPK pathways.
  
  
  CONCLUSIONS
  The specific microRNA expression profiles of lung adenocarcinoma in cases found in Xuanwei region allow for a better understanding of the pathogenesis of lung adenocarcinoma in Xuanwei. The predicted target genes may involve the PI3K/Alt, WNT and MAPK pathways.
authors.affiliation: Department of Thoracic Surgery, Third Affiliated Hospital of Kunming Medical University/Tumor Hospital of Yunnan Province/Yunnan Key Laboratory of Lung Cancer Research, Kunming 650000, China a. E-mail: ady_2010@qq.com.
authors.forename: Shuai
authors.initials: S
authors.lastname: Chen
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Zhou
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Chen
authors.forename: Guang-Jian
authors.initials: GJ
authors.lastname: Li
authors.forename: Jia-Peng
authors.initials: JP
authors.lastname: Yang
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Lei
authors.forename: Guang-Qiang
authors.initials: GQ
authors.lastname: Zhao
authors.forename: Qiu-Bo
authors.initials: QB
authors.lastname: Huang
authors.forename: Chang-Shao
authors.initials: CS
authors.lastname: Yang
authors.forename: Ya-Xi
authors.initials: YX
authors.lastname: DU
authors.forename: Yun-Chao
authors.initials: YC
authors.lastname: Huang
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism*; D000077192:Adenocarcinoma of Lung; D019295:Computational Biology; D020869:Gene Expression Profiling; D006801:Humans; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs