title: Numerical and experimental investigations of the flow-pressure relation in multiple sequential stenoses coronary artery.
abstract: Virtual fractional flow reserve (vFFR) has been evaluated as an adjunct to invasive fractional flow reserve (FFR) in the light of its operational and economic benefits. The accuracy of vFFR and the complexity of hyperemic flow simulation are still not clearly understood. This study investigates the flow-pressure relation in an idealised multiple sequential stenoses coronary artery model via numerical and experimental approaches. Pressure drop is linearly correlated with flow rate irrespective of the number of stenosis. Computational fluid dynamics results are in good agreement with the experimental data, demonstrating reasonable accuracy of vFFR. It was also found that the difference between data obtained with steady and pulsatile flows is negligible, indicating the steady flow may be used instead of pulsatile flow conditions in vFFR computation. This study adds to the current understanding of vFFR and may improve its clinical applicability as an adjunct to invasively determined FFR.
authors.affiliation: Department of Mechanical Engineering, Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Mechanical Engineering, The University of Adelaide, Adelaide, SA, Australia.
authors.forename: Cheng
authors.initials: C
authors.lastname: Chin
authors.affiliation: Department of Medicine, Faculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Vikas
authors.initials: V
authors.lastname: Thondapu
authors.affiliation: Department of Mechanical Engineering, Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Eric K W
authors.initials: EKW
authors.lastname: Poon
authors.affiliation: Department of Mechanical Engineering, Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Jason P
authors.initials: JP
authors.lastname: Monty
authors.affiliation: Division of Image Processing, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. yingguangli133@gmail.com.
authors.forename: Yingguang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Mechanical Engineering, Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Andrew S H
authors.initials: ASH
authors.lastname: Ooi
authors.affiliation: School of Biomedical Engineering, Biomedical Instrument Institute, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Shengxian
authors.initials: S
authors.lastname: Tu
authors.affiliation: Department of Mechanical Engineering, Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia.|Department of Medicine, Faculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Barlis
mesh_terms: D062186:Arterial Pressure; D001783:Blood Flow Velocity; D003198:Computer Simulation; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000503:physiopathology; D003331:Coronary Vessels / Q000503:physiopathology*; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D057446:Hydrodynamics; D006940:Hyperemia / Q000503:physiopathology; D016014:Linear Models; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D009716:Numerical Analysis, Computer-Assisted; D011237:Predictive Value of Tests; D011379:Prognosis; D011673:Pulsatile Flow; D012720:Severity of Illness Index
keywords: Computational fluid dynamics; Flow–pressure relation; Fractional flow reserve