title: African Ancestry Gradient Is Associated with Lower Systemic F2-Isoprostane Levels.
abstract: Context. Low levels of systemic F2-isoprostanes (F2-IsoP) increase the risk of diabetes and weight gain and were found in African Americans. Low F2-IsoPs could reflect an unfavorable metabolic characteristic, namely, slow mitochondrial metabolism in individuals with African ancestry.Objective. To examine differences in plasma F2-IsoPs in three groups with a priori different proportion of African ancestry: non-Hispanic Whites (NHWs), US-born African Americans (AAs), and West African immigrants (WAI).Design. Cross-sectional study.Setting. Georgia residents recruited from church communities.Participants. 218 males and females 25-74 years of age, who are self-identified as NHW (n= 83), AA (n= 56), or WAI (n= 79).Main Outcome Measure(s). Plasma F2-IsoPs quantified by gas chromatography-mass spectrometry.Results. After adjustment for age, gender, obesity, and other comorbidities, WAI had lower levels of plasma F2-IsoP than AA (beta-coefficient = -9.8,p< 0.001) and AA had lower levels than NHW (beta-coefficient = -30.3,p< 0.001). Similarly, among healthy nonobese participants, F2-IsoP levels were lowest among WAI, followed by AA, and the highest levels were among NHW.Conclusion. Plasma F2-IsoPs are inversely associated with African ancestry gradient. Additional studies are required to test whether optimization of systemic F2-IsoP levels can serve as means to improve race-specific lifestyle and pharmacological intervention targeted to obesity prevention and treatment.
authors.affiliation: Division of Epidemiology and Biostatistics, School of Public Health, Georgia State University, One Park Place, Suite 630, Atlanta, GA 30303, USA.
authors.forename: Francis
authors.initials: F
authors.lastname: Annor
authors.affiliation: Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA.
authors.forename: Michael
authors.identifier: 0000-0001-6956-6879
authors.initials: M
authors.lastname: Goodman
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware St SE b435, Minneapolis, MN 55455, USA.
authors.forename: Bharat
authors.identifier: 0000-0001-6968-6985
authors.initials: B
authors.lastname: Thyagarajan
authors.affiliation: Division of Epidemiology and Biostatistics, School of Public Health, Georgia State University, One Park Place, Suite 630, Atlanta, GA 30303, USA.
authors.forename: Ike
authors.initials: I
authors.lastname: Okosun
authors.affiliation: Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, MD 20892, USA.
authors.forename: Ayo
authors.identifier: 0000-0001-9494-7710
authors.initials: A
authors.lastname: Doumatey
authors.affiliation: Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd., Birmingham, AL 35294, USA.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Gower
authors.affiliation: Division of Epidemiology and Biostatistics, School of Public Health, Georgia State University, One Park Place, Suite 630, Atlanta, GA 30303, USA.
authors.forename: Dora
authors.identifier: 0000-0003-4290-6794
authors.initials: D
authors.lastname: Il'yasova
mesh_terms: D000328:Adult; D000354:Africa, Western / Q000208:ethnology; D001741:Black or African American / Q000208:ethnology; D000368:Aged; D015415:Biomarkers / Q000097:blood; D044383:Black People / Q000145:classification / Q000208:ethnology; D003430:Cross-Sectional Studies; D028441:F2-Isoprostanes / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000208:ethnology; D018384:Oxidative Stress; D044465:White People
chemical_list: D015415:Biomarkers; D028441:F2-Isoprostanes