title: CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study.
abstract: OBJECTIVE
  To understand the relationships between CDH13 (T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors.
  
  
  METHODS
  We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight (HMW) adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model.
  
  
  RESULTS
  In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels (per T: Coef = -0.257, P = 0.001). CDH13 rs7193788 was associated with total adiponectin levels (per A: Coef = -0.221, P = 0.001) and HMW adiponectin levels (per A: Coef = -0.163, P = 0.003). rs7193788 was significantly associated with ischemic stroke (GA/AA vs. GG: OR = 1.55, 95% CI: 1.07 to 2.24, P = 0.020) after Bonferroni correction (α = 0.025). There was an interaction between rs7193788 and diabetes (P = 0.036). Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke (OR = 2.64, 95% CI: 1.58-4.40, P < 0.001).
  
  
  CONCLUSIONS
  CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke.
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Ke Xin
authors.initials: KX
authors.lastname: Sun
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Juan
authors.affiliation: Beijing Center for Disease Prevention and Control, Beijing 100013, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Fang
authors.affiliation: Department of Epidemiology & Biostatistics, Capital Medical University, Beijing 100069, China.
authors.forename: Kuo
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Xue Yin
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Pingshan New District Center for Disease Control and Prevention, Shenzhen 518118, Guangdong, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.affiliation: Shilou Township Hospital, Beijing 102422, China.
authors.forename: Xiao Qiang
authors.initials: XQ
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Yi Qun
authors.initials: YQ
authors.lastname: Wu
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Xue Ying
authors.initials: XY
authors.lastname: Qin
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Da Fang
authors.initials: DF
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Yong Hua
authors.initials: YH
authors.lastname: Hu
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D002545:Brain Ischemia / Q000097:blood / Q000235:genetics*; D015820:Cadherins / Q000235:genetics*; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000235:genetics*
chemical_list: D052242:Adiponectin; D015820:Cadherins; C099972:H-cadherin
keywords: Adiponectin; CDH13; Genetic polymorphisms; Ischemic stroke; Sib pair