title: Breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression.
abstract: Breviscapine, extracted from the herbErigeron breviscapus, is widely used for the treatment of cardiovascular diseases, cerebral infarct, and stroke, but its mechanism of action remains unclear. This study established a rat model of traumatic brain injury induced by controlled cortical impact, and injected 75 μg breviscapineviathe right lateral ventricle. We found that breviscapine significantly improved neurobehavioral dysfunction at 6 and 9 days after injection. Meanwhile, interleukin-6 expression was markedly down-regulated following breviscapine treatment. Our results suggest that breviscapine is effective in promoting neurological behavior after traumatic brain injury and the underlying molecular mechanism may be associated with the suppression of interleukin-6.
authors.affiliation: Institute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Ling
authors.identifier: 0000-0001-7135-2925
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Institute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Institute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: He
authors.affiliation: Institute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lv
authors.affiliation: Institute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Ting-Hua
authors.initials: TH
authors.lastname: Wang
authors.affiliation: Institute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Qing-Jie
authors.initials: QJ
authors.lastname: Xia
keywords: breviscapine; interleukin-6; nerve regeneration; neural regeneration; neuroprotective effect; traumatic brain injury