title: A novel dimorphic pathogen, Emergomyces orientalis (Onygenales), agent of disseminated infection.
abstract: A novel dimorphic fungus, Emergomyces orientalis sp. nov. a close relative of systemic pathogens in the family Ajellomycetaceae (Blastomyces, Histoplasma). The fungus is reported in a 64-year-old male from Shanxi, China. The patient developed disseminated skin lesions, productive cough with fever and showed nodular opacities in his left lung on chest radiography. The patient had no identified cause of immunodeficiency apart from type-2 diabetes mellitus. Clinical, histopathological and mycological characteristics of the agent are given, and its phylogenetic position is determined with multilocus sequence data.
authors.affiliation: Division of Clinical Microbiology, P.U.M.C.H., Beijing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Sexually Transmitted Infection Unit, Institute of Tropical Medicine, Antwerp, Belgium.
authors.forename: Chris
authors.initials: C
authors.lastname: Kenyon
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
authors.forename: Sybren
authors.initials: S
authors.lastname: de Hoog
authors.affiliation: Division of Clinical Microbiology, P.U.M.C.H., Beijing, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Guo
authors.affiliation: Division of Internal Medicine, P.U.M.C.H., Beijing, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Fan
authors.affiliation: Division of Pathology, P.U.M.C.H., Beijing, China.
authors.forename: Hongrui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Division of Bioinformatics, Academy of Military Medical Science, Beijing Institute of Radiation Medicine, Beijing, China.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Li
authors.affiliation: Division of Internal Medicine, P.U.M.C.H., Beijing, China.
authors.forename: Ruiyuan
authors.initials: R
authors.lastname: Sheng
authors.affiliation: Division of Fungi, Academy of Military Medical Science, Beijing Institute of Radiation Medicine, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.|Department of Dermatology, The Affiliated Hospital, Guizhou Medical University, Guiyang, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Division of Clinical Microbiology, P.U.M.C.H., Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Division of Clinical Microbiology, P.U.M.C.H., Beijing, China.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Xu
mesh_terms: D001758:Blastomyces / Q000235:genetics; D002681:China; D004275:DNA, Ribosomal; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000382:microbiology; D005334:Fever / Q000209:etiology / Q000382:microbiology; D006658:Histoplasma / Q000235:genetics; D006801:Humans; D000072742:Invasive Fungal Infections / Q000175:diagnosis* / Q000382:microbiology*; D008168:Lung / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D020036:Onygenales / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity*; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D012867:Skin / Q000382:microbiology / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D004275:DNA, Ribosomal
keywords: 
  Emergomyces
  ; 
  Emmonsia
  ; AIDS-related mycosis; diabetes; dimorphic fungi; endemic mycosis