title: Status of HBsAg seroprevalence in 15 million rural couples in China: a cross-sectional study.
abstract: A cross-sectional analysis of prevalence of hepatitis B virus infection (HBV) among rural couples was conducted between 2010 and 2014. Serologic HBV markers, including hepatitis B surface antigen (HBsAg) and e antigen (HBeAg), were tested. Primary outcome of interest comprised HBsAg positivity in couples (both positive: F+M+, only wife positive: F+M-, only husband positive: F-M+), and secondary outcome consisted of prevalence and risk factors of HBsAg positivity among husbands or wives. Of 14,816,300 couples included, 0.7% were F+M+; 6.3% were F-M+; 4.4% were F+M-, resulting in the overall seroprevalence of 11.4%. Individually, 6.1% were HBsAg positive with a higher rate seen in husbands (7.0%) than in wives (5.2%). Wife's HBeAg(+)/HBsAg (+) (AOR = 2.61), HBeAg(-)/HBsAg (+) (AOR = 2.23), positivity of syphilis (AOR = 1.50), living in a high-risk region (AOR = 1.46) were significantly predictors of HBsAg positivity in husbands. Prevalence and predictors of HBsAg positivity in wives had similar results. Our data show a high burden and discordant pattern of HBV infection in rural couples, and partner's double positivity of HBeAg and HBsAg was the most significant factor of HBV infection in couples. A comprehensive strategy that emphasizes vaccination and education is needed.
authors.affiliation: Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.|Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.|National Research Institute for Family Planning, Beijing, China.|Graduate School of Peking Union Medical College, Beijing, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Wang
authors.affiliation: Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.|Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.
authors.forename: Yan-Jie
authors.initials: YJ
authors.lastname: Huang
authors.affiliation: Department of Maternal and Child Health, National Health and Family Planning Commission of the PRC, Beijing, China.
authors.forename: Qiao-Mei
authors.initials: QM
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.
authors.forename: Kenrad E
authors.initials: KE
authors.lastname: Nelson
authors.affiliation: Department of Child, Adolescent and Women's Health, School of Public Health, Peking University, Beijing, China.
authors.forename: An-Qi
authors.initials: AQ
authors.lastname: Wang
authors.affiliation: Department of Maternal and Child Health, National Health and Family Planning Commission of the PRC, Beijing, China.
authors.forename: Hai-Ping
authors.initials: HP
authors.lastname: Shen
authors.affiliation: Department of Child, Adolescent and Women's Health, School of Public Health, Peking University, Beijing, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Liu
authors.affiliation: Department of Maternal and Child Health, National Health and Family Planning Commission of the PRC, Beijing, China.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Zhang
authors.affiliation: Department of Maternal and Child Health, National Health and Family Planning Commission of the PRC, Beijing, China.
authors.forename: Dong-Hai
authors.initials: DH
authors.lastname: Yan
authors.affiliation: National Research Institute for Family Planning, Beijing, China.
authors.forename: Zuo-Qi
authors.initials: ZQ
authors.lastname: Peng
authors.affiliation: National Research Institute for Family Planning, Beijing, China.
authors.forename: Hong-Guang
authors.initials: HG
authors.lastname: Zhang
authors.affiliation: National Research Institute for Family Planning, Beijing, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: National Research Institute for Family Planning, Beijing, China.|Graduate School of Peking Union Medical College, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: National Research Institute for Family Planning, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: National Research Institute for Family Planning, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.affiliation: National Research Institute for Family Planning, Beijing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: He
authors.affiliation: National Research Institute for Family Planning, Beijing, China.
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Xu
authors.affiliation: National Research Institute for Family Planning, Beijing, China.|Graduate School of Peking Union Medical College, Beijing, China.
authors.forename: Du-Jia
authors.initials: DJ
authors.lastname: Liu
authors.affiliation: National Research Institute for Family Planning, Beijing, China.|Graduate School of Peking Union Medical College, Beijing, China.
authors.forename: Tong-Jun
authors.initials: TJ
authors.lastname: Guo
authors.affiliation: National Research Institute for Family Planning, Beijing, China.|Graduate School of Peking Union Medical College, Beijing, China.
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Xin
authors.affiliation: Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.|Department of Child, Adolescent and Women's Health, School of Public Health, Peking University, Beijing, China.|Key Laboratory of Reproductive Health, Ministry of Health, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.|National Research Institute for Family Planning, Beijing, China.|Graduate School of Peking Union Medical College, Beijing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005191:Family Characteristics; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis* / Q000453:epidemiology; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006513:Hepatitis B e Antigens / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012424:Rural Population; D013587:Syphilis / Q000175:diagnosis / Q000453:epidemiology; D055815:Young Adult
chemical_list: D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens