title: I2-Mediated Intramolecular C-H Amidation for the Synthesis of N-Substituted Benzimidazoles.
abstract: A practical intramolecular C-H amidation methodology has been developed using molecular iodine under basic conditions. The required imine substrates were readily obtained by condensation of simple o-phenylenediamine derivatives and aldehydes. The transition-metal-free cyclization reaction described here works well with crude imines and allows for the sequential synthesis of N-protected benzimidazoles without purification of the less stable condensation intermediates. This operationally simple synthetic approach is broadly applicable to a variety of aromatic, aliphatic, and cinnamic aldehydes to produce diverse 1,2-disubstituted benzimidazole derivatives in an efficient and scalable fashion.
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan Province 450001, People's Republic of China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Hu
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan Province 450001, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan Province 450001, People's Republic of China.
authors.forename: Manman
authors.initials: M
authors.lastname: Wang
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan Province 450001, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan Province 450001, People's Republic of China.
authors.forename: Wenquan
authors.identifier: 0000-0002-3711-0006
authors.initials: W
authors.lastname: Yu
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan Province 450001, People's Republic of China.
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang