title: Recent Advances in Synthesis and Identification of Cyclic Peptides for Bioapplications.
abstract: Cyclic peptides, owing to their good stability, high resistance to exo- and to some extent endo-peptidases, enhanced binding affinity and selectivity towards target biomolecules, are actively investigated as biochemical tools and therapeutic agents. In this review, we discuss various commonly utilized synthetic strategies for cyclic peptides and peptoids (peptidomimetics), their important screening methods to identify the bioactive cyclic peptides and peptoids such as combinatorial beadbased peptide library, phage display, mRNA display etc. and recent advances in their applications as bioactive compounds. Lastly, we also make a summary and provide an outlook of the research area.
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
authors.forename: Yong Siang
authors.initials: YS
authors.lastname: Ong
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
authors.forename: Liqian
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Chemical Engineering, Imperial College London, South Kensington Campus, London - SW7 2AZ, United Kingdom.
authors.forename: Karunakaran A
authors.initials: KA
authors.lastname: Kalesh
authors.affiliation: School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Yu
authors.affiliation: College of Life Sciences, The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China.
authors.forename: Jigang
authors.initials: J
authors.lastname: Wang
authors.affiliation: Bioprocessing Technology Institute, 20 Biopolis Way, #06-01 Centros, Singapore 138668, Singapore.
authors.forename: Chengcheng
authors.initials: C
authors.lastname: Liu
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Sun
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
authors.forename: Su Seong
authors.initials: SS
authors.lastname: Lee
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D019151:Peptide Library; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D057786:Peptidomimetics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D019151:Peptide Library; D010456:Peptides, Cyclic; D057786:Peptidomimetics
keywords: Bead-based library; Computational; Cyclic peptide; Cyclization; Phage display; mRNA display