title: Orthogonal near-infrared upconversion co-regulated site-specific O2delivery and photodynamic therapy for hypoxia tumor by using red blood cell microcarriers.
abstract: Pre-existing hypoxia in tumors can result in an inadequate oxygen supply during photodynamic therapy (PDT), which in turn hampers photodynamic efficacy. To overcome this problem, we developed an orthogonal near-infrared upconversion controlled red blood cell (RBC) microcarriers to selectively deliver O2in hypoxia area. Moreover, this RBC microcarriers are able to overcome a series of complex biological barriers which include transporting across the inflamed endothelium, evading mononuclear phagocyte system, reducing reticuloendothelial system uptake. Based on these abilities, RBC microcarriers have efficient tumors accumulation and are capable of delivery a large amount of O2for PDT under near-infrared (NIR) irradiation to realize effective solid tumor eradication.
authors.affiliation: Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China.
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China.
authors.forename: Chi
authors.initials: C
authors.lastname: Yao
authors.affiliation: Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China.
authors.forename: Wenxing
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China.
authors.forename: Mengyao
authors.initials: M
authors.lastname: Zhao
authors.affiliation: King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, 11451, Saudi Arabia; Central Metallurgical Research and Development Institute, CMRDI, Helwan, 11421, Cairo, Egypt.
authors.forename: Ahmed Mohamed
authors.initials: AM
authors.lastname: El-Toni
authors.affiliation: Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China. Electronic address: zhang_fan@fudan.edu.cn.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002214:Capsules / Q000737:chemistry / Q000528:radiation effects; D003131:Combined Modality Therapy / Q000379:methods; D003692:Delayed-Action Preparations / Q000008:administration & dosage*; D017707:Erythrocyte Transfusion / Q000379:methods*; D004912:Erythrocytes / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D007259:Infrared Rays; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D010100:Oxygen / Q000008:administration & dosage* / Q000097:blood; D010778:Photochemotherapy / Q000379:methods*; D016896:Treatment Outcome; D000072258:Tumor Hypoxia / Q000187:drug effects*
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D010100:Oxygen
keywords: Biological barriers; Hypoxia; Photodynamic therapy; Upconversion