title: Positive Minimal Residual Disease of FLT3-ITD before Hematopoietic Stem Cell Transplantation Resulted in a Poor Prognosis of an Acute Myeloid Leukemia.
abstract: Acute myeloid leukemia (AML) patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) often have a poor prognosis, even after hematopoietic stem cell transplantation (HSCT). We report a case of AML with FLT3-ITD identified upon initial diagnosis, who received HSCT at complete remission after 3 consecutive chemotherapies. However, the patient relapsed when the same FLT3-ITD clone emerged, and finally died. Retrospective analysis revealed an allelic ratio of FLT3-ITD/wild type of 1.1 and 0.0096 upon initial diagnosis and before HSCT, respectively. The detection of any minimal residual FLT3-ITD clone before HSCT is useful in the treatment of AML with FLT3-ITD.
authors.affiliation: Department of Pediatrics, Kochi Health Sciences Center, Kochi 781-8555, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Rituo
authors.initials: R
authors.lastname: Nishiuchi
authors.forename: Michinori
authors.initials: M
authors.lastname: Aoe
authors.forename: Takahide
authors.initials: T
authors.lastname: Takahashi
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Watanabe
authors.forename: Chiho
authors.initials: C
authors.lastname: Tokorotani
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kikkawa
authors.forename: Akira
authors.initials: A
authors.lastname: Shimada
mesh_terms: D002648:Child; D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy; D018365:Neoplasm, Residual; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012008:Recurrence; D019172:Transplantation Conditioning; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
chemical_list: C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3
keywords: FLT3-ITD; HSCT; acute myeloid leukemia; minimal residual disease; relapse