title: A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy.
abstract: A mitochondria-targeting supramolecular photosensitizer system TPP-QAS/WP5/DTAB was constructed based on a host-guest inclusion complex. The supramolecular system could efficiently release and activate TPP-QASs in an acidic environment, which have been demonstrated to preferentially accumulate in mitochondria. Singlet oxygen (1O2) could be in situ generated in mitochondria under light irradiation, further enhancing the PDT efficacy.
authors.affiliation: Shanghai Key Laboratory of Advanced Polymeric Materials, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. wazhang@ecust.edu.cn.
authors.forename: Leilei
authors.initials: L
authors.lastname: Rui
authors.affiliation: Shanghai Key Laboratory of Advanced Polymeric Materials, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. wazhang@ecust.edu.cn.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Xue
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing 210009, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Advanced Polymeric Materials, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. wazhang@ecust.edu.cn.
authors.forename: Yun
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Shanghai Key Laboratory of Advanced Polymeric Materials, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. wazhang@ecust.edu.cn.
authors.forename: Weian
authors.initials: W
authors.lastname: Zhang
mesh_terms: D047250:Calixarenes; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism*; D015394:Molecular Structure; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D046911:Macromolecular Substances; D017319:Photosensitizing Agents; D000644:Quaternary Ammonium Compounds; C570642:pillar(5)arene; D047250:Calixarenes