title: Shift work and colorectal cancer risk in the MCC-Spain case-control study.
abstract: Objectives Shift work that involves circadian disruption has been associated with a higher cancer risk. Most epidemiological studies to date have focused on breast cancer risk and evidence for other common tumors is limited. We evaluated the risk for colorectal cancer (CRC) in relation to shift work history in a population-based case-control study in Spain. Methods This analysis included 1626 incident CRC cases and 3378 randomly selected population controls of both sexes, enrolled in 11 regions of Spain. Sociodemographic and lifestyle information was assessed in face-to-face interviews. Shift work was assessed in detail throughout lifetime occupational history. We estimated the risk of colon and rectal cancer associated with rotating and permanent shift work (ever, cumulative duration, age of first exposure) using unconditional logistic regression analysis adjusting for potential confounders. Results Having ever performed rotating shift work (morning, evening and/or night) was associated with an increased risk for CRC [odds ratio (OR) 1.22, 95% confidence interval (95% CI) 1.04-1.43], as compared to day workers. Having ever worked permanent night shifts (≥3 nights/month) was not associated with CRC risk (OR 0.79, 95% CI 0.62-1.00). OR increased with increasing lifetime cumulative duration of rotating shift work (P-value for trend 0.005) and were highest among subjects in the top quartiles of exposure (3rdquartile, 20-34 years, OR 1.38, 95%CI 1.06-1.81; 4thquartile, ≥35 years, OR 1.36, 95% CI 1.02-1.79). Conclusions These data suggest that rotating shift work may increase the risk of CRC especially after long-term exposures.
authors.affiliation: Department of Epidemiology, Medical University of Vienna, Kinderspitalgasse 15, 1090 Vienna Austria. kyriaki.papantoniou@meduniwien.ac.at.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Papantoniou
authors.forename: Gemma
authors.initials: G
authors.lastname: Castaño-Vinyals
authors.forename: Ana
authors.initials: A
authors.lastname: Espinosa
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Turner
authors.forename: Maria Henar
authors.initials: MH
authors.lastname: Alonso-Aguado
authors.forename: Vicente
authors.initials: V
authors.lastname: Martin
authors.forename: Nuria
authors.initials: N
authors.lastname: Aragonés
authors.forename: Beatriz
authors.initials: B
authors.lastname: Pérez-Gómez
authors.forename: Benito Mirón
authors.initials: BM
authors.lastname: Pozo
authors.forename: Inés
authors.initials: I
authors.lastname: Gómez-Acebo
authors.forename: Eva
authors.initials: E
authors.lastname: Ardanaz
authors.forename: Jone M
authors.initials: JM
authors.lastname: Altzibar
authors.forename: Rosana
authors.initials: R
authors.lastname: Peiro
authors.forename: Adonina
authors.initials: A
authors.lastname: Tardon
authors.forename: José Andrés
authors.initials: JA
authors.lastname: Lorca
authors.forename: Maria Dolores
authors.initials: MD
authors.lastname: Chirlaque
authors.forename: Andrés
authors.initials: A
authors.lastname: García-Palomo
authors.forename: Jose Juan
authors.initials: JJ
authors.lastname: Jimenez-Moleon
authors.forename: Trinidad
authors.initials: T
authors.lastname: Dierssen
authors.forename: Maria
authors.initials: M
authors.lastname: Ederra
authors.forename: Pilar
authors.initials: P
authors.lastname: Amiano
authors.forename: Marina
authors.initials: M
authors.lastname: Pollan
authors.forename: Victor
authors.initials: V
authors.lastname: Moreno
authors.forename: Manolis
authors.initials: M
authors.lastname: Kogevinas
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002940:Circadian Rhythm; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D016272:Occupational Health; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014940:Work Schedule Tolerance