title: Nutritional Recovery after Open and Laparoscopic Distal Gastrectomy for Early Gastric Cancer: A Prospective Multicenter Comparative Trial (CCOG1204).
abstract: BACKGROUND
  Little information from prospective clinical trials is available on the influences of surgical approaches on postoperative body compositions and nutritional status. We designed a prospective non-randomized trial to compare postoperative chronological changes in body composition and nutritional status between laparoscopic and open distal gastrectomy for stage I gastric cancer (GC).
  
  
  METHODS
  Body compositions and nutritional indicators in blood tests were measured at the baseline and at the 1st, 3rd, 6th, and 12th postoperative months (POM). The primary end point was the decrease relative to the baseline in the body muscle mass at POM 6.
  
  
  RESULTS
  Ninety-six patients for the laparoscopic group and 52 for the open group were eligible for data analysis. No significant differences were found in any baseline demographics, body compositions, and nutritional indicators between the groups. The changes of body muscle mass at POM 6 were similar in both groups. Overall, no significant differences between the groups were observed in any of the body composition and nutritional indicators during the first year after surgery.
  
  
  CONCLUSIONS
  Postoperative body compositions and nutritional status were not affected by surgical approaches during the first 12 months after surgery in patients who underwent distal gastrectomy for stage I GC.
authors.affiliation: Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Matsushita
authors.forename: Chie
authors.initials: C
authors.lastname: Tanaka
authors.forename: Kenta
authors.initials: K
authors.lastname: Murotani
authors.forename: Kazunari
authors.initials: K
authors.lastname: Misawa
authors.forename: Seiji
authors.initials: S
authors.lastname: Ito
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ito
authors.forename: Mitsuro
authors.initials: M
authors.lastname: Kanda
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Mochizuki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ishigure
authors.forename: Toyohisa
authors.initials: T
authors.lastname: Yaguchi
authors.forename: Jin
authors.initials: J
authors.lastname: Teramoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakayama
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kawase
authors.forename: Michitaka
authors.initials: M
authors.lastname: Fujiwara
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kodera
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D000368:Aged; D001823:Body Composition; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011184:Postoperative Period; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000601:surgery*; D016896:Treatment Outcome
keywords: Body composition; Distal gastrectomy; Gastric cancer; Laparoscopic surgery; Nutritional status