title: [Stevens-Johnson syndrome/toxic epidermal necrolysis after initiation of carbamazepine in a HLA-B*15:02 gene carrier – screening in risk patients is recommended].
abstract: Stevens-Johnson syndrome/toxic epidermal necrolysis after initiation of carbamazepine in a HLA-B*15:02 gene carrier - screening in risk patients is recommended A 32-year-old woman, adopted from Indonesia, developed Stevens-Johnsons syndrome (SJS)/toxic epidermal necrolysis (TEN) after initiating carbamazepine treatment for epilepsy. SJS and TEN are rare but life-threatening adverse effects of carbamazepine, with a 72-100% risk of occurrence in patients carrying the HLA-B*15:02 allele. The HLA-B*15:02 allele is common in several Asian groups but less prevalent in European populations. Screening for HLA-B*15:02, or choice of medication other than aromatic anticonvulsants in patients with Asian ancestry, is recommended when treatment with carbamazepine is considered.
authors.affiliation: Astrid Lindgrens Barnsjukhuset, Karolinska Universitetssjukhuset Solna - Neuropediatriken, Q2:02 Stockholm, Sweden Astrid Lindgrens Barnsjukhuset, Karolinska Universitetssjukhuset Solna - Neuropediatriken, Q2:02 Stockholm, Sweden.
authors.forename: Stavroula
authors.initials: S
authors.lastname: Anastasopoulou
authors.affiliation: Hudkliniken, Gävle Sjukhus - Gävle, Sweden Hudkliniken, Gävle Sjukhus - Gävle, Sweden.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Komuda
authors.affiliation: Plastikkirurgi och Brännskadeintensivvårdsavdelning, Akademiska  Universitetssjukhus - Uppsala, Sweden Plastikkirurgi och Brännskadeintensivvårdsavdelning, Akademiska  Universitetssjukhus - Uppsala, Sweden.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Presman
authors.affiliation: Hudkliniken, Karolinska Universitetssjukhuset Solna - Stockholm, Sweden Hudkliniken, Karolinska Universitetssjukhuset Solna - Stockholm, Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Karlsson
authors.affiliation: Karolinska Universitetssjukhuset Neurologiska kliniken - Stockholm, Sweden Karolinska Universitetssjukhuset Neurologiska kliniken - Stockholm, Sweden.
authors.forename: Torbjörn
authors.initials: T
authors.lastname: Tomson
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D044466:Asian People / Q000235:genetics; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D004829:Epilepsy, Generalized / Q000188:drug therapy; D005260:Female; D059910:HLA-B15 Antigen / Q000235:genetics; D006801:Humans; D007214:Indonesia / Q000208:ethnology; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D013548:Sweden
chemical_list: D000927:Anticonvulsants; C483536:HLA-B*15:02 antigen; D059910:HLA-B15 Antigen; D002220:Carbamazepine