title: Porous Inorganic Drug Delivery Systems-a Review.
abstract: Innovative methods and materials have been developed to overcome limitations associated with current drug delivery systems. Significant developments have led to the use of a variety of materials (as excipients) such as inorganic and metallic structures, marking a transition from conventional polymers. Inorganic materials, especially those possessing significant porosity, are emerging as good candidates for the delivery of a range of drugs (antibiotics, anticancer and anti-inflammatories), providing several advantages in formulation and engineering (encapsulation of drug in amorphous form, controlled delivery and improved targeting). This review focuses on key selected developments in porous drug delivery systems. The review provides a short broad overview of porous polymeric materials for drug delivery before focusing on porous inorganic materials (e.g. Santa Barbara Amorphous (SBA) and Mobil Composition of Matter (MCM)) and their utilisation in drug dosage form development. Methods for their preparation and drug loading thereafter are detailed. Several examples of porous inorganic materials, drugs used and outcomes are discussed providing the reader with an understanding of advances in the field and realistic opportunities.
authors.affiliation: Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK.|Department of Pharmaceutical Technology, Faculty of Pharmacy, Minia University, Minia, Egypt.
authors.forename: E
authors.initials: E
authors.lastname: Sayed
authors.affiliation: Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK.
authors.forename: R
authors.initials: R
authors.lastname: Haj-Ahmad
authors.affiliation: Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK.
authors.forename: K
authors.initials: K
authors.lastname: Ruparelia
authors.affiliation: Department of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan.
authors.forename: M S
authors.initials: MS
authors.lastname: Arshad
authors.affiliation: College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, 310027, China.|Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, 310027, China.
authors.forename: M-W
authors.initials: MW
authors.lastname: Chang
authors.affiliation: Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK. zahmad@dmu.ac.uk.
authors.forename: Z
authors.initials: Z
authors.lastname: Ahmad
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007287:Inorganic Chemicals / Q000737:chemistry / Q000494:pharmacology; D000073396:Metal-Organic Frameworks / Q000737:chemistry / Q000494:pharmacology; D053758:Nanoparticles; D016062:Porosity
chemical_list: D007287:Inorganic Chemicals; D000073396:Metal-Organic Frameworks
keywords: drug delivery; inorganic; mesoporous; nanoparticles; porous materials