title: The effect of oxidized phospholipids on phenotypic polarization and function of macrophages.
abstract: Oxidized phospholipids are products of lipid oxidation that are found on oxidized low-density lipoproteins and apoptotic cell membranes. These biologically active lipids were shown to affect a variety of cell types and attributed pro-as well as anti-inflammatory effects. In particular, macrophages exposed to oxidized phospholipids drastically change their gene expression pattern and function. These 'Mox,'macrophages were identified in atherosclerotic lesions, however, it remains unclear how lipid oxidation products are sensed by macrophages and how they influence their biological function. Here, we review recent developments in the field that provide insight into the structure, recognition, and downstream signaling of oxidized phospholipids in macrophages.
authors.affiliation: Robert M. Berne Cardiovascular Research Center and Department of Pharmacology, University of Virginia, USA.
authors.forename: Vlad
authors.initials: V
authors.lastname: Serbulea
authors.affiliation: Robert M. Berne Cardiovascular Research Center and Department of Pharmacology, University of Virginia, USA.
authors.forename: Dory
authors.initials: D
authors.lastname: DeWeese
authors.affiliation: Robert M. Berne Cardiovascular Research Center and Department of Pharmacology, University of Virginia, USA.
authors.forename: Norbert
authors.initials: N
authors.lastname: Leitinger
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D006801:Humans; D008077:Lipoproteins, LDL / Q000276:immunology / Q000378:metabolism*; D051218:Lymphocyte Antigen 96 / Q000235:genetics / Q000276:immunology; D008264:Macrophages / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D010084:Oxidation-Reduction; D010641:Phenotype; D010743:Phospholipids / Q000276:immunology / Q000378:metabolism*; D058226:Plaque, Atherosclerotic / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000235:genetics / Q000276:immunology
chemical_list: D015703:Antigens, CD; C495377:LY96 protein, human; D008077:Lipoproteins, LDL; D051218:Lymphocyte Antigen 96; D010743:Phospholipids; D051193:Toll-Like Receptors; C099252:oxidized low density lipoprotein
keywords: Inflammation; Macrophages; Oxidized phospholipids