title: Theoretical and practical aspects of using fetal fibroblasts for skin regeneration.
abstract: Cutaneous wounding in late-gestational fetal or postnatal humans results in scar formation without any skin appendages. Early or mid- gestational skin healing in humans is characterized by the absence of scaring in a process resembling regeneration. Tremendous cellular and molecular mechanisms contribute to this distinction, and fibroblasts play critical roles in scar or scarless wound healing. This review discussed the different repair mechanisms involved in wound healing of fibroblasts at different developmental stages and further confirmed that fetal fibroblast transplantation resulted in reduced scar healing in vivo. We also discussed the possible problem in fetal fibroblast transplantation for wound repair. We proposed the use of small molecules to improve the regenerative potential of repairing cells in the wound given that remodeling of the wound microenvironment into a regenerative microenvironment in adults might improve skin regeneration.
authors.affiliation: Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, PR China; Trauma Treatment Center, Central Laboratory, Chinese PLA General Hospital Hainan branch, 9 Haitang Bay, sanya 572014, PR China; Chinese PLA General Hospital Hainan branch, 9 Haitang Bay, Sanya 572014, PR China.
authors.forename: Meirong
authors.initials: M
authors.lastname: Li
authors.affiliation: Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, PR China; Trauma Treatment Center, Central Laboratory, Chinese PLA General Hospital Hainan branch, 9 Haitang Bay, sanya 572014, PR China; Chinese PLA General Hospital Hainan branch, 9 Haitang Bay, Sanya 572014, PR China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, PR China.
authors.forename: Haojie
authors.initials: H
authors.lastname: Hao
authors.affiliation: Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, PR China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Han
authors.affiliation: Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, PR China. Electronic address: fuxiaobing@vip.sina.com.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Fu
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D053686:Fetal Stem Cells / Q000637:transplantation*; D005333:Fetus; D005347:Fibroblasts / Q000637:transplantation*; D006801:Humans; D011247:Pregnancy; D012038:Regeneration / Q000502:physiology*; D012879:Skin Physiological Phenomena; D033581:Stem Cell Transplantation / Q000379:methods / Q000639:trends; D014945:Wound Healing / Q000502:physiology
keywords: Fibroblasts; In situ regeneration; Skin regeneration; Small molecular