title: Predicting risk for portal vein thrombosis in acute pancreatitis patients: A comparison of radical basis function artificial neural network and logistic regression models.
abstract: To construct a radical basis function (RBF) artificial neural networks (ANNs) model to predict the incidence of acute pancreatitis (AP)-induced portal vein thrombosis.
  
  
  
  The analysis included 353 patients with AP who had admitted between January 2011 and December 2015. RBF ANNs model and logistic regression model were constructed based on eleven factors relevant to AP respectively. Statistical indexes were used to evaluate the value of the prediction in two models.
  
  
  
  The predict sensitivity, specificity, positive predictive value, negative predictive value and accuracy by RBF ANNs model for PVT were 73.3%, 91.4%, 68.8%, 93.0% and 87.7%, respectively. There were significant differences between the RBF ANNs and logistic regression models in these parameters (P<0.05). In addition, a comparison of the area under receiver operating characteristic curves of the two models showed a statistically significant difference (P<0.05).
  
  
  
  The RBF ANNs model is more likely to predict the occurrence of PVT induced by AP than logistic regression model. D-dimer, AMY, Hct and PT were important prediction factors of approval for AP-induced PVT.
authors.affiliation: Surgical Intensive Care Unit (SICU), Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Fei
authors.affiliation: School of mechanical engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Hu
authors.affiliation: Surgical Intensive Care Unit (SICU), Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
authors.affiliation: Surgical Intensive Care Unit (SICU), Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Tu
authors.affiliation: Surgical Intensive Care Unit (SICU), Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China. Electronic address: chamskuler@163.com.
authors.forename: Wei-Qin
authors.initials: WQ
authors.lastname: Li
authors.affiliation: Department of General Surgery, Bayi Hospital Affiliated Nanjing University of Chinese Medicine/The 81st Hospital of P.L.A., Nanjing 210002, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000502:physiology; D010195:Pancreatitis / Q000150:complications*; D011169:Portal Vein; D012372:ROC Curve; D012044:Regression Analysis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D020246:Venous Thrombosis / Q000209:etiology*
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D
keywords: Logistic regression; Neural network; Pancreatitis; Radical basis function; Thrombosis