title: Collapsing glomerulopathy in systemic lupus erythematosus.
abstract: Collapsing glomerulopathy (CG) is a rare disease that can be associated with multiple other disorders. It usually leads to poor prognosis with a high percentage of patients progressing to end-stage renal disease. In this article, we illustrate a clinical case of CG associated with systemic lupus erythematosus that had a prompt response to mycophenolate and prednisone. The condition started after sudden cessation of the already established mycophenolate treatment regimen. The patient then presented with acute kidney injury due to kidney biopsy-proven CG. In that circumstance, we hypothesised that mycophenolate may play a role in prevention and development of CG.
authors.affiliation: Department of Nephrology and Hypertension, Mayo Clinic Florida, Jacksonville, Florida, USA.
authors.forename: Kerolos
authors.initials: K
authors.lastname: Abadeer
authors.affiliation: Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA.
authors.forename: Ali A
authors.identifier: http://orcid.org/0000-0001-9143-5269
authors.initials: AA
authors.lastname: Alsaad
authors.affiliation: Department of Pathology and Laboratory Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA.
authors.forename: Xochiquetzal J
authors.initials: XJ
authors.lastname: Geiger
authors.affiliation: Department of Nephrology and Hypertension, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Ivan E
authors.initials: IE
authors.lastname: Porter
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D000328:Adult; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007678:Kidney Glomerulus; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D008181:Lupus Nephritis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D055118:Medication Adherence; D009173:Mycophenolic Acid / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid