title: Relationship between the Level of Circulating CD45+Platelets and Development of Restenosis after Implantation of Drug-Eluting Stents to Patients with Coronary Heart Disease.
abstract: The study was carried out in 126 patients with stable angina pectoris, who underwent elective coronary artery stenting with drug-eluting stents and follow-up angiography within 6-12 months thereafter. Five significant risk factors of restenosis were identified by binary comparisons of different variables. The logistic regression equation that included the level of CD45-positive platelets, diabetes, small vessel stenting, number of simultaneously implanted stents in one patient, and lesion length demonstrates the highest level of prediction of in-stent restenosis (OR=22.8; p<0.001). ROC-analysis demonstrated high prognostic value of the logit model (area under ROC curve 0.87, p<0.001). The data suggest that a close relationship exists between the development of restenosis and the level of circulating CD45+platelets.
authors.affiliation: Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia. zufargabbasov@yandex.ru.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Gabbasov
authors.affiliation: Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: S G
authors.initials: SG
authors.lastname: Kozlov
authors.affiliation: Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Byazrova
authors.affiliation: Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: I S
authors.initials: IS
authors.lastname: Mel'nikov
authors.affiliation: Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Saburova
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology*; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003331:Coronary Vessels / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D003920:Diabetes Mellitus / Q000503:physiopathology; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005260:Female; D015870:Gene Expression; D006801:Humans; D017493:Leukocyte Common Antigens / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D017493:Leukocyte Common Antigens
keywords: CD45 + platelets; coronary heart disease; drug-eluting stents; restenosis