title: An unusual cause of food-induced anaphylaxis in mothers.
abstract: BACKGROUND
  Galacto-oligosaccharides (GOS) are prebiotics added to commercial milk formula of infants and mothers. In recent years, cases of allergy related to GOS in atopic children have been reported in the South East Asian region.
  
  
  METHODS
  We describe a series of pregnant (n= 4) and lactating mothers (n= 2) who developed anaphylactic reactions after consumption of maternal milk formula containing GOS. All six subjects had pre-existing atopy and a positive skin prick test to GOS and 5/5 of the subjects who were tested had positive basophil activation tests to GOS. All of the mothers and their babies had normal neonatal outcomes after the reactions.
  
  
  CONCLUSIONS
  The supplementation of GOS into milk and beverages in the Asian region should take into account the rare chance of allergenicity of GOS in the atopic population.
authors.affiliation: Department of Paediatrics, National University Hospital, Tower Block Level 12, 1E Kent Ridge Road, Singapore, 119228 Singapore ; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
authors.forename: J Y
authors.identifier: 0000-0002-6135-9434
authors.initials: JY
authors.lastname: Soh
authors.affiliation: Department of Paediatrics, Kandang Kerbau Women's and Children's Hospital, Singapore, Singapore.
authors.forename: W C
authors.initials: WC
authors.lastname: Chiang
authors.affiliation: Department of Paediatrics, National University Hospital, Tower Block Level 12, 1E Kent Ridge Road, Singapore, 119228 Singapore ; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
authors.forename: C H
authors.initials: CH
authors.lastname: Huang
authors.affiliation: Department of Medicine, Gleneagles Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
authors.forename: C K
authors.initials: CK
authors.lastname: Woo
authors.affiliation: Emergency Medicine Department, National University Hospital, National University Health System, Singapore, Singapore ; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
authors.forename: I
authors.initials: I
authors.lastname: Ibrahim
authors.affiliation: Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore ; Emergency Department, Tan Tock Seng Hospital, Singapore, Singapore.
authors.forename: K
authors.initials: K
authors.lastname: Heng
authors.affiliation: Department of Obstetrics and Gynaecology, Kandang Kerbau Women's and Children's Hospital, Singapore, Singapore.
authors.forename: A
authors.initials: A
authors.lastname: Pramanick
authors.affiliation: Department of Paediatrics, National University Hospital, Tower Block Level 12, 1E Kent Ridge Road, Singapore, 119228 Singapore ; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
authors.forename: B W
authors.initials: BW
authors.lastname: Lee
keywords: Anaphylaxis; Galacto-Oligosaccharide; Pregnancy