title: Relation of Iliac Artery Calcium With Adiposity Measures and Peripheral Artery Disease.
abstract: Arterial calcification is associated with cardiovascular morbidity and mortality. To improve the understanding of the pathogenesis involved with iliac artery calcium (IAC), we sought to examine the associations between the burden of IAC with adiposity measures and peripheral artery disease (PAD). Participants (n = 1,236, 52% women, mean age 60 years) were drawn from the Framingham Heart Study Offspring cohort who underwent multidetector computed tomography. The extent of IAC was quantified based on calcified atherosclerotic plaques detected in the iliac arteries. High IAC was defined based on gender-specific 90th percentile cut-off points from a healthy referent subsample. PAD is defined as an ankle-brachial index < 0.9, intermittent claudication, and/or history of lower extremity revascularization. The association between PAD and IAC was assessed using multivariable-adjusted logistic regression models. The burden of high IAC was 20.5% in women and 25.5% in men. High IAC was not associated with generalized (body mass index) or area-specific (waist circumference, and volumes of thoracic periaortic, abdominal subcutaneous, and visceral adipose tissue) adiposity measures (all p ≥0.22). High IAC was associated with increased odds of PAD (odds ratio 10.36, 95% confidence interval 4.28 to 25.09). This association persisted even after additionally adjusting for coronary artery calcium (odds ratio 11.25, 95% confidence interval 4.29 to 29.53). Burden of IAC was associated with an increased risk of PAD.
authors.affiliation: Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.
authors.forename: Jane J
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.
authors.forename: Alison
authors.initials: A
authors.lastname: Pedley
authors.affiliation: Division of Cardiology, Fireman Vascular Center and the Vascular Medicine Section, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Ido
authors.initials: I
authors.lastname: Weinberg
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Britton
authors.affiliation: Department of Biostatistics, Boston University, Boston, Massachusetts.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Massaro
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Udo
authors.initials: U
authors.lastname: Hoffmann
authors.affiliation: Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.
authors.forename: Emily
authors.initials: E
authors.lastname: Manders
authors.affiliation: Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts; Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Caroline S
authors.initials: CS
authors.lastname: Fox
authors.affiliation: Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts; Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts. Electronic address: Murabito@bu.edu.
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Murabito
mesh_terms: D050218:Body Fat Distribution; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007083:Iliac Artery / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D058729:Peripheral Arterial Disease / Q000150:complications*; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging; D061205:Vascular Calcification / Q000150:complications / Q000000981:diagnostic imaging*; D055105:Waist Circumference