title: Preparation of Magnetic Nanoparticles for Biomedical Applications.
abstract: Magnetic nanoparticles have obtained great attention in the field of biomedicine in recent years owing to their excellent biocompatibility, unique magnetic properties, and ease of functionalization. Potential applications for functionalized magnetic nanoparticles span biomedical imaging, treatment via magnetic hyperthermia, drug delivery, and biosensing. This chapter provides detailed procedures for the synthesis, PEGylation, and bioconjugation of monodispersed Fe3O4nanoparticles, hollow Fe3O4nanoparticles, porous hollow Fe3O4nanoparticles, and dumbbell-like Au-Fe3O4nanoparticles. We hope this article can help readers design and reproducibly prepare high-quality magnetic nanoparticles with their specific goals in mind.
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 261005, China.
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Chemistry, Brown University, Box H, 324 Brooke Street, Providence, RI, 02912, USA. shouheng_sun@brown.edu.
authors.forename: Shouheng
authors.initials: S
authors.lastname: Sun
mesh_terms: D060326:Chemistry Techniques, Synthetic; D004298:Dopamine / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D018796:Immunoconjugates; D007074:Immunoglobulin G; D008024:Ligands; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010743:Phospholipids / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D016062:Porosity; D013499:Surface Properties
chemical_list: D005290:Ferric Compounds; D018796:Immunoconjugates; D007074:Immunoglobulin G; D008024:Ligands; D058185:Magnetite Nanoparticles; D010743:Phospholipids; C000499:ferric oxide; D011092:Polyethylene Glycols; D004298:Dopamine
keywords: EDC/NHS coupling; IgG; Iron oxide nanoparticles; Organic phase synthesis; PEGylation