title: Concomitant Use of Panobinostat and Reirradiation in Progressive DIPG: Report of 2 Cases.
abstract: Diffuse intrinsic pontine glioma (DIPG) remains a devastating disease. Panobinostat has been shown to have therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models; however, clinical data in patients with DIPG are lacking. We present 2 cases of DIPG, who were treated with panobinostat at 22 to 25 mg/m/dose, 3 times weekly for 2 weeks in 3-week cycles and concomitant reirradiation after disease progression. Two episodes of asymptomatic thrombocytopenia were observed in 1 patient. Hyperacetylation of histone H4 of peripheral blood mononuclear cells was evident following treatment. In our experience, panobinostat administered with reirradiation was well tolerated at a relatively higher dose than that used in adult studies.
authors.affiliation: Departments of *Pediatrics, Division of Pediatric Hematology Oncology †Oncology, Molecular Therapeutics Program ‡Radiology §Pathology ∥Neurosurgery, Children's Hospital of Michigan #Radiation Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI ¶Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA.
authors.forename: Zhihong J
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Yubin
authors.initials: Y
authors.lastname: Ge
authors.forename: Deniz
authors.initials: D
authors.lastname: Altinok
authors.forename: Janet
authors.initials: J
authors.lastname: Poulik
authors.forename: Sandeep
authors.initials: S
authors.lastname: Sood
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Taub
authors.forename: Holly
authors.initials: H
authors.lastname: Edwards
authors.forename: Mark W
authors.initials: MW
authors.lastname: Kieran
authors.forename: Miller
authors.initials: M
authors.lastname: Steven
mesh_terms: D000107:Acetylation; D002675:Child, Preschool; D003131:Combined Modality Therapy; D018450:Disease Progression; D004334:Drug Administration Schedule; D005260:Female; D005910:Glioma / Q000188:drug therapy* / Q000532:radiotherapy*; D006657:Histones / Q000378:metabolism; D006801:Humans; D006877:Hydroxamic Acids / Q000008:administration & dosage*; D007211:Indoles / Q000008:administration & dosage*; D000077767:Panobinostat; D000069475:Re-Irradiation; D013921:Thrombocytopenia / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D006657:Histones; D006877:Hydroxamic Acids; D007211:Indoles; D000077767:Panobinostat