title: Association of a common variant of SYNPO2 gene with increased risk of serous epithelial ovarian cancer.
abstract: In China, the majority of ovarian cancer patients (80%-90%) are women who are diagnosed with epithelial ovarian cancer. The SYNPO2 gene has recently been reported to be associated with epithelial ovarian cancer in Europeans. To investigate the association of common variants of SYNPO2 gene with epithelial ovarian cancer in Han Chinese individuals, we designed a case-control study with 719 epithelial ovarian cancer patients and 1568 unrelated healthy controls of Han Chinese descent. A total of 49 tagging single-nucleotide polymorphisms were genotyped; single-single-nucleotide polymorphism association, imputation, and haplotypic association analyses were performed. The single-nucleotide polymorphism rs17329882 was found to be strongly associated with serous epithelial ovarian cancer and with ages ≤49 years, consistent with the pre-menopausal status of analyzed epithelial ovarian cancer cases. Odds ratios and 95% confidence intervals provided evidence of the risk effects of the C allele of the single-nucleotide polymorphism on epithelial ovarian cancer. Imputation analyses also confirmed the results with a similar pattern. Additionally, haplotype analyses indicated that the haplotype block that contained rs17329882 was significantly associated with epithelial ovarian cancer risk, specifically with the serous epithelial ovarian cancer subtype. In conclusion, our results show that SYNPO2 gene plays an important role in the etiology of epithelial ovarian cancer, suggesting that this gene may be a potential genetic modifier for developing epithelial ovarian cancer.
authors.affiliation: 1 Department of Pathology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.affiliation: 2 Department of Scientific Research, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: 3 Department of Oncology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
authors.forename: Zhaoli
authors.initials: Z
authors.lastname: Ding
authors.affiliation: 4 Department of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, Saint Louis, MO, USA.
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Wu
authors.affiliation: 1 Department of Pathology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yaofeng
authors.initials: Y
authors.lastname: Jin
authors.affiliation: 5 Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Na
authors.initials: N
authors.lastname: Jiang
authors.affiliation: 6 Department of Pathology, Maternity and Children Hospital of Shaanxi Province, Xi'an, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Du
authors.affiliation: 7 Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Dongge
authors.initials: D
authors.lastname: Cai
authors.affiliation: 1 Department of Pathology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Li
authors.initials: L
authors.lastname: Miao
authors.affiliation: 1 Department of Pathology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Chen
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D000077216:Carcinoma, Ovarian Epithelial; D016022:Case-Control Studies; D018284:Cystadenocarcinoma, Serous / Q000235:genetics* / Q000473:pathology; D005006:Ethnicity / Q000235:genetics; D005260:Female; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide
chemical_list: D008840:Microfilament Proteins; C503979:SYNPO2 protein, human
keywords: Epithelial ovarian cancer; Han Chinese; SYNPO2; common variants; susceptibility