title: N-Hydroxyimide Ugi Reaction toward α-Hydrazino Amides.
abstract: The Ugi four-component reaction (U-4CR) with N-hydroxyimides as a novel carboxylic acid isostere has been reported. This reaction provides straightforward access to α-hydrazino amides. A broad range of aldehydes, amines, isocyanides and N-hydroxyimides were employed to give products in moderate to high yields. This reaction displays N-N bond formation by cyclic imide migration in the Ugi reaction. Thus, N-hydroxyimide is added as a new acid component in the Ugi reaction and broadens the scaffold diversity.
authors.affiliation: Department of Drug Design, University of Groningen , Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: Ajay L
authors.identifier: 0000-0001-8236-9626
authors.initials: AL
authors.lastname: Chandgude
authors.affiliation: Department of Drug Design, University of Groningen , Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: Alexander
authors.identifier: 0000-0002-9923-8873
authors.initials: A
authors.lastname: Dömling