title: Circulating microRNAs and extracellular vesicles as potential cancer biomarkers: a systematic review.
abstract: Circulating non-coding RNAs, including microRNAs and long non-coding RNAs, and the protein components of extracellular vesicles are promising biomarkers for the non-invasive detection of cancer at an early stage. This systematic review discusses the increasing number of well-designed cancer biomarker-related studies that have been published worldwide. In many of these studies, high diagnostic accuracy, which is represented as the area under the receiver operating characteristic curve being >0.8, could be achieved using combinations of circulating microRNAs. In addition, similar diagnostic accuracies were reported using long non-coding RNAs or proteins present in extracellular vesicles, although these evidences were based on a limited number of studies.
authors.affiliation: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors.forename: Juntaro
authors.identifier: http://orcid.org/0000-0002-3204-5049
authors.initials: J
authors.lastname: Matsuzaki
authors.affiliation: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. tochiya@ncc.go.jp.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ochiya
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D000067128:Extracellular Vesicles / Q000235:genetics / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000032:analysis* / Q000097:blood; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000032:analysis / Q000097:blood; D012372:ROC Curve
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D062085:RNA, Long Noncoding
keywords: Cancer; Extracellular vesicle; Liquid biopsy; Long non-coding RNA; MicroRNA