title: Genomic analysis of aStreptococcus pyogenesstrain causing endocarditis in a child.
abstract: We sequenced the genome ofStreptococcus pyogenesstrain G773 that caused an infective endocarditis in a 4-year-old boy suffering from acute endocarditis. The 1.9-Mb genome exhibited a specific combination of virulence factors including a complete integrative and conjugative element, sp2905, previously described as incomplete inS.pyogenes, and five bacteriocin-coding genes. However, strain G773 lacked a CRISPR-Cas system.
authors.affiliation: URMITE, UM63, CNRS7278, IRD198, Inserm1095, Institut Hospitalo-Universitaire Méditerranée-infection, Aix-Marseille Université, Faculté de Médecine, Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Beye
authors.affiliation: URMITE, UM63, CNRS7278, IRD198, Inserm1095, Institut Hospitalo-Universitaire Méditerranée-infection, Aix-Marseille Université, Faculté de Médecine, Marseille, France.
authors.forename: K
authors.initials: K
authors.lastname: El Karkouri
authors.affiliation: URMITE, UM63, CNRS7278, IRD198, Inserm1095, Institut Hospitalo-Universitaire Méditerranée-infection, Aix-Marseille Université, Faculté de Médecine, Marseille, France.
authors.forename: N
authors.initials: N
authors.lastname: Labas
authors.affiliation: URMITE, UM63, CNRS7278, IRD198, Inserm1095, Institut Hospitalo-Universitaire Méditerranée-infection, Aix-Marseille Université, Faculté de Médecine, Marseille, France; Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdul Aziz University, Jeddah, Saudi Arabia.
authors.forename: D
authors.initials: D
authors.lastname: Raoult
authors.affiliation: URMITE, UM63, CNRS7278, IRD198, Inserm1095, Institut Hospitalo-Universitaire Méditerranée-infection, Aix-Marseille Université, Faculté de Médecine, Marseille, France.
authors.forename: P-E
authors.initials: PE
authors.lastname: Fournier
keywords: Endocarditis; Streptococcus pyogenes; genome comparison; real-time genome sequencing; virulence