title: Prenatal Stress Impairs Spatial Learning and Memory Associated with Lower mRNA Level of the CAMKII and CREB in the Adult Female Rat Hippocampus.
abstract: Prenatal stress (PS) results in various behavioral and emotional alterations observed in later life. In particular, PS impairs spatial learning and memory processes but the underlying mechanism involved in this pathogenesis still remains unknown. Here, we reported that PS lowered the body weight in offspring rats, particularly in female rats, and impaired spatial learning and memory of female offspring rats in the Morris water maze. Correspondingly, the decreased CaMKII and CREB mRNA in the hippocampus were detected in prenatally stressed female offspring, which partially explained the effect of PS on the spatial learning and memory. Our findings suggested that CaMKII and CREB may be involved in spatial learning and memory processes in the prenatally stressed adult female offspring.
authors.affiliation: Shaanxi Institute of Pediatric Diseases, Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 86-710003, People's Republic of China.|Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 86-710061, People's Republic of China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of PICU, Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 86-710003, People's Republic of China.
authors.forename: Haibin
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Neonatology, Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 86-710003, People's Republic of China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 86-710061, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wen
authors.affiliation: College of Life Sciences, Shaanxi Province Biomedicine Key Laboratory, Northwest University, Shaanxi, 86-710069, People's Republic of China.
authors.forename: Zhongliang
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Neonatology, Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 86-710003, People's Republic of China. huili@mail.xjtu.edu.cn.|Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 86-710061, People's Republic of China. huili@mail.xjtu.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
mesh_terms: D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology / Q000378:metabolism* / Q000523:psychology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism* / Q000523:psychology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D065853:Spatial Learning / Q000502:physiology*; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism* / Q000523:psychology
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D012333:RNA, Messenger; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2
keywords: CAMKII; CREB; Learning and memory; Offspring; Prenatal stress