title: Safety and efficiency of flow diverters for treating small intracranial aneurysms: A systematic review and meta-analysis.
abstract: Background We evaluated the safety and efficiency of flow diverters (FDs) in treating small intracranial aneurysms (IAs). Materials and Methods We reviewed the literature published in PubMed and EMBASE. R for Project software was used to calculate the complete aneurysm occlusion rates, procedure-related neurologic mortality, procedure-related neurologic morbidity and procedure-related permanent morbidity. Results Ten observational studies were included in this analysis. The complete aneurysm occlusion rate was 84.23% (80.34%-87.76%), the procedure-related neurologic mortality was 0.87% (0.29%-1.74%), the procedure-related neurologic morbidity rate was 5.22% (3.62%-7.1%), the intracerebral haemorrhage rate was 1.42% (0.64%-2.49%), the ischemic rate was 2.35% (1.31%-3.68%), the subarachnoid haemorrhage rate was 0.03% (0%-0.32%) and the procedure-related permanent morbidity was 2.41% (0.81%-4.83%). Conclusions Treatment of small IAs with FDs may be correlated with high complete occlusion rates and low complication rates. Future long-term follow-up randomized trials will determine the optimal treatment for small IAs.
authors.affiliation: 1 Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Xiyang
authors.initials: X
authors.lastname: Yao
authors.affiliation: 1 Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.|2 Department of Neurosurgery, Suzhou Kowloon Hospital Affiliated with Shanghai Jiao Tong University, Suzhou, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Ma
authors.affiliation: 1 Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Li
authors.affiliation: 1 Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Shen
authors.affiliation: 3 Department of Neurosurgery, Taicang First People's Hospital, Taicang, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Lu
authors.affiliation: 1 Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D057510:Endovascular Procedures / Q000295:instrumentation; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000401:mortality / Q000601:surgery*; D020766:Intracranial Embolism / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D061214:Patient Safety; D011446:Prospective Studies; D012189:Retrospective Studies; D013345:Subarachnoid Hemorrhage / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: SILK; flow diverters; meta-analysis; pipeline; small intracranial aneurysms; systematic review