title: Short-duration transient visual evoked potentials and color reflectivity discretization analysis in glaucoma patients and suspects.
abstract: OBJECTIVE
  To evaluate the use of short-duration transient visual evoked potentials (VEP) and color reflectivity discretization analysis (CORDA) in glaucomatous eyes, eyes suspected of having glaucoma, and healthy eyes.
  
  
  METHODS
  The study included 136 eyes from 136 subjects: 49 eyes with glaucoma, 45 glaucoma suspect eyes, and 42 healthy eyes. Subjects underwent Humphrey visual field (VF) testing, VEP testing, as well as peripapillary retinal nerve fiber layer optical coherence tomography imaging studies with post-acquisition CORDA applied. Statistical analysis was performed using means and ranges, ANOVA, post-hoc comparisons using Turkey's adjustment, Fisher's Exact test, area under the curve, and Spearman correlation coefficients.
  
  
  RESULTS
  Parameters from VEP and CORDA correlated significantly with VF mean deviation (MD) (P<0.05). In distinguishing glaucomatous eyes from controls, VEP demonstrated area under the curve (AUC) values of 0.64-0.75 for amplitude and 0.67-0.81 for latency. The CORDA HR1 parameter was highly discriminative for glaucomatous eyesvscontrols (AUC=0.94).
  
  
  CONCLUSIONS
  Significant correlations are found between MD and parameters of short-duration transient VEP and CORDA, diagnostic modalities which warrant further consideration in identifying glaucoma characteristics.
authors.affiliation: Wills EyeHospital Glaucoma Research Center, Philadelphia, PA 19107, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Waisbourd
authors.affiliation: Wills EyeHospital Glaucoma Research Center, Philadelphia, PA 19107, USA.
authors.forename: Rebekah H
authors.initials: RH
authors.lastname: Gensure
authors.affiliation: Wills EyeHospital Glaucoma Research Center, Philadelphia, PA 19107, USA.
authors.forename: Ardalan
authors.initials: A
authors.lastname: Aminlari
authors.affiliation: Wills EyeHospital Glaucoma Research Center, Philadelphia, PA 19107, USA.
authors.forename: Sonya B
authors.initials: SB
authors.lastname: Shah
authors.affiliation: Wills EyeHospital Glaucoma Research Center, Philadelphia, PA 19107, USA.
authors.forename: Nitasha
authors.initials: N
authors.lastname: Khanna
authors.affiliation: Wills EyeHospital Glaucoma Research Center, Philadelphia, PA 19107, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Sood
authors.affiliation: Wills EyeHospital Glaucoma Research Center, Philadelphia, PA 19107, USA.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Molineaux
authors.affiliation: Diopsys Inc., Pine Brook, NJ 07058, USA.
authors.forename: Alberto
authors.initials: A
authors.lastname: Gonzalez
authors.affiliation: Wills EyeHospital Glaucoma Research Center, Philadelphia, PA 19107, USA.
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Myers
authors.affiliation: Wills EyeHospital Glaucoma Research Center, Philadelphia, PA 19107, USA.
authors.forename: L Jay
authors.initials: LJ
authors.lastname: Katz
keywords: color reflectivity discretization analysis; glaucoma; optical coherence tomography; short-duration transient visual evoked potentials