title: Spontaneous bone formation after mandible segmental resection in "krokodil" drug-related jaw osteonecrosis patient: case report.
abstract: We report a case of a 48-year-old male patient with "krokodil" drug-related osteonecrosis of both jaws. Patient history included 1.5 years of "krokodil" use, with 8-month drug withdrawal prior to surgery. The patient was HCV positive. On the maxilla, sequestrectomy was performed. On the mandible, sequestrectomy was combined with bone resection. From ramus to ramus, segmental defect was formed, which was not reconstructed with any method. Post-operative follow-up period was 3 years and no disease recurrence was noted. On 3-year post-operative orthopantomogram, newly formed mandibular bone was found. This phenomenon shows that spontaneous bone formation is possible after mandible segmental resection in osteonecrosis patients.
authors.affiliation: Department of Maxillofacial Surgery of "Kanaker-Zeytun" m/c, 7 H Nersisyan Str., 0014, Yerevan, Armenia. hakobyankoryun@yandex.ru.
authors.forename: Koryun
authors.initials: K
authors.lastname: Hakobyan
authors.affiliation: Chair of Postgraduate Maxillofacial Surgery, Yerevan State Medical University, 2 Koryun Str, 0025, Yerevan, Armenia.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Poghosyan
mesh_terms: D000701:Analgesics, Opioid / Q000633:toxicity; D001136:Armenia; D001861:Bone Regeneration / Q000502:physiology*; D003061:Codeine / Q000031:analogs & derivatives* / Q000633:toxicity; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D008336:Mandibular Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D008437:Maxilla / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D008439:Maxillary Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D008875:Middle Aged; D009294:Narcotics / Q000009:adverse effects; D010020:Osteonecrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D011862:Radiography, Panoramic
chemical_list: D000701:Analgesics, Opioid; D009294:Narcotics; C000599494:desomorphine; D003061:Codeine
keywords: Bone formation; Jaw osteonecrosis; Jaw resection; “Krokodil” drug