title: New triterpenoidal saponins fromKoelreuteria paniculata.
abstract: Bioassay guided fractionation and chemical investigation of the ethanolic extract of the aerial parts ofKoelreuteria paniculataLaxm. (Sapindaceae), resulted in the isolation and identification of three new triterpenoid saponins1-3named Paniculatosoid A-C, along with eleven known compounds. The structures of the isolated compounds were elucidated using 1D and 2D NMR experiments, HRESIMS, and comparison with literature data. The occurrence of tridesmosidic saponin is reported for the first time from family Sapindaceae, as well as it is rarely found in natural saponins. Compounds4-13were evaluated for their antibacterial, antifungal, antimalarial and antileishmanial activities. Compound 12 showed weak antibacterial activity againstEscherichia coliwith an IC50value of 101 μM. Compounds12and13showed antimalarial activity against chloroquine-sensitive (D6)Plasmodium falciparumprotozoan with IC50values of 6.46 and 6.95 μM, and against chloroquine-resistant (W2)Plasmodium falciparumprotozoan with IC50values of 9.34 and 4.18 μM.
authors.affiliation: National Center for Natural Products Research, The University of Mississippi, University, MS 38677, USA; Department of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo 11371, Egypt.
authors.forename: Ahmad E
authors.initials: AE
authors.lastname: Mostafa
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo 11371, Egypt.
authors.forename: Atef A
authors.initials: AA
authors.lastname: El-Hela
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo 11371, Egypt.
authors.forename: Abd-Elsalam I
authors.initials: AI
authors.lastname: Mohammad
authors.affiliation: Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Cutler
authors.affiliation: National Center for Natural Products Research, The University of Mississippi, University, MS 38677, USA; Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Samir A
authors.initials: SA
authors.lastname: Ross
keywords: Antimalarial; Koelreuteria paniculata; Sapindaceae; Tridesmosidic saponin; Triterpenes