title: Fast Electrocatalytic Determination of Methimazole at an Activated Glassy Carbon Electrode.
abstract: A fast and simple voltammetric method for the determination of methimazole in pharmaceutical products was reported. A glassy carbon electrode was pretreated by anodization at +1.75 V (vs. SCE) for 5 min, followed by potential cycling in the range of 0.3-1.3 V (20 cycles). The pretreated electrode showed an excellent electrocatalytic effect on the oxidation of methimazole. Compared with untreated electrode, a large decrease (~300 mV) in the oxidation peak of methimazole was observed. The oxidation peak current at the new potential (0.4 V vs. SCE) was linearly dependent on the concentration of methimazole in the range of 7.0 - 130 μM with a detection limit of 3.7 μM (S/N = 3). The method was successfully used in the determination of methimazole in thyramozol tablets. Due to the simple and fast electrode preparation, there is no need for electrode cleaning or storage.
authors.affiliation: Department of Chemistry, Faculty of Science, Razi University, 67346, Kermanshah, Iran.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Jalali
authors.affiliation: Department of Chemistry, Faculty of Science, Razi University, 67346, Kermanshah, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Hatami
keywords: Methimazole; Pretreated glassy carbon electrode; Square wave voltammetry; Tablets