title: Furanyl Cyclic Ethers: Single and Double Diastereoselectivity in the Synthesis of 2,4-Di and 2,4,5-Trisubstituted Tetrahydropyrans.
abstract: Combining the desymmetrization of a prochiral bis-hydroxymethyl group with the epimerization of a chiral furanyl ether in a single transformation, high levels of double diastereoselectivity have been achieved in a synthesis of 2,4,5-trisubstituted tetrahydropyrans, which proceeds under thermodynamic control.
authors.affiliation: Lennard-Jones Building, School of Chemical and Physical Sciences, Keele University , Borough of Newcastle-under-Lyme, Staffordshire ST5 5BG, U.K.
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Cooper
authors.affiliation: Lennard-Jones Building, School of Chemical and Physical Sciences, Keele University , Borough of Newcastle-under-Lyme, Staffordshire ST5 5BG, U.K.
authors.forename: Emma
authors.initials: E
authors.lastname: Robbins
authors.affiliation: National Crystallography Service, University of Southampton , Southampton SO17 1BJ, U.K.
authors.forename: Graham J
authors.initials: GJ
authors.lastname: Tizzard
authors.affiliation: National Crystallography Service, University of Southampton , Southampton SO17 1BJ, U.K.
authors.forename: Simon J
authors.identifier: 0000-0001-8414-9272
authors.initials: SJ
authors.lastname: Coles
authors.affiliation: Lennard-Jones Building, School of Chemical and Physical Sciences, Keele University , Borough of Newcastle-under-Lyme, Staffordshire ST5 5BG, U.K.
authors.forename: Matthew
authors.initials: M
authors.lastname: O'Brien