title: Trajectories of Depression in Late Life: A 1-Year Follow-Up Study.
abstract: To investigate the prognosis of depression in late life (DLL) in terms of the course of depression over 1 year and assess clinical factors related to the prognosis.
  
  
  
  We performed an observational, multicenter, longitudinal study of 160 patients aged ≥60 years who were admitted to inward treatment of DLL. The patients were followed with 3 assessments: at inclusion (T0), at discharge from the hospital (T1), and after 1 year (T2). Growth mixture modeling was applied to identify patient classes following distinct trajectories of the Montgomery-Åsberg Depression Rating Scale (MADRS) score. Two regression models were estimated to assess clinical factors for the trajectories and for a clinical assessment of the depression course between T1 and T2.
  
  
  
  Two trajectory classes were identified: one with higher and one with lower MADRS scores. Not being in remission at T1 and a longer hospital stay were associated with higher odds of being in the trajectory class with more severe depression. Early-onset depression (EOD) was associated with higher odds of being in a group with a poorer clinical course between T1 and T2.
  
  
  
  EOD and not being in remission at discharge were important negative prognostic factors for DLL.
authors.affiliation: Center for Old Age Psychiatric Research, Innlandet Hospital Trust, Ottestad, Norway.
authors.forename: Tom
authors.initials: T
authors.lastname: Borza
authors.forename: Knut
authors.initials: K
authors.lastname: Engedal
authors.forename: Sverre
authors.initials: S
authors.lastname: Bergh
authors.forename: Jūratė Šaltytė
authors.initials: JŠ
authors.lastname: Benth
authors.forename: Geir
authors.initials: G
authors.lastname: Selbæk
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology / Q000628:therapy; D004565:Electroconvulsive Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000067562:Late Onset Disorders; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D010043:Outcome and Process Assessment, Health Care; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D011613:Psychotherapy / Q000379:methods*; D012074:Remission Induction
chemical_list: D000928:Antidepressive Agents