title: Muscle Interstitial Cells: A Brief Field Guide to Non-satellite Cell Populations in Skeletal Muscle.
abstract: Skeletal muscle regeneration is mainly enabled by a population of adult stem cells known as satellite cells. Satellite cells have been shown to be indispensable for adult skeletal muscle repair and regeneration. In the last two decades, other stem/progenitor cell populations resident in the skeletal muscle interstitium have been identified as "collaborators" of satellite cells during regeneration. They also appear to have a key role in replacing skeletal muscle with adipose, fibrous, or bone tissue in pathological conditions. Here, we review the role and known functions of these different interstitial skeletal muscle cell types and discuss their role in skeletal muscle tissue homeostasis, regeneration, and disease, including their therapeutic potential for cell transplantation protocols.
authors.affiliation: Department of Cell and Developmental Biology, University College London, Gower Street, WC1E 6DE, London, UK. f.s.tedesco@ucl.ac.uk.
authors.forename: Francesco Saverio
authors.initials: FS
authors.lastname: Tedesco
authors.affiliation: Department of Cell and Developmental Biology, University College London, Gower Street, WC1E 6DE, London, UK.
authors.forename: Louise A
authors.initials: LA
authors.lastname: Moyle
authors.affiliation: Cell Biology Group, Department of Experimental and Health Sciences (DCEXS), Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), 08003, Barcelona, Spain. eusebio.perdiguero@upf.edu.
authors.forename: Eusebio
authors.initials: E
authors.lastname: Perdiguero
mesh_terms: D000071916:AC133 Antigen / Q000378:metabolism; D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D018482:Muscle, Skeletal / Q000166:cytology*; D020286:Pericytes / Q000166:cytology / Q000378:metabolism; D010641:Phenotype; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*
chemical_list: D000071916:AC133 Antigen; D015415:Biomarkers; D051741:Kruppel-Like Transcription Factors
keywords: Fibro-adipogenic progenitors; Interstitial cells; Mesenchymal progenitors; Mesoangioblasts; Muscle regeneration; Pericytes; Pw1; Skeletal muscle; Stem cells