title: Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities.
abstract: Bioassay-guided phytochemical investigation of the EtOAc fraction (ST-EtOAc) from the roots of Sophora tonkinensis resulted in the isolation of a new compound 6aR,11aR-1-hydroxy-4-isoprenyl-maackiain (1), along with 12 known compounds (2-13). The structure of the new compound was established by 1D and 2D NMR, MS data and circular dichroism analysis. Polyprenylated flavonoids 6-9 and 11-13 increased GLUT-4 translocation by the range of 1.35-2.75 folds. Sophoranone (8) exerted the strongest activity with 2.75 folds GLUT-4 translocation enhancement at the concentration of 10μM. This is the first report of the GLUT-4 translocation activity of the plant Sophora tonkinensis.
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Xinzhou
authors.initials: X
authors.lastname: Yang
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Shihao
authors.initials: S
authors.lastname: Deng
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Mi
authors.initials: M
authors.lastname: Huang
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Jialin
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Mingrui
authors.initials: M
authors.lastname: Xiong
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Sijiang
authors.initials: S
authors.lastname: Zheng
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Ma
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. Electronic address: p.zhao@scuec.edu.cn.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.affiliation: Eskitis Institute, School of Natural Sciences, Griffith University, Brisbane, QLD 4111, Australia. Electronic address: y.feng@griffith.edu.au.
authors.forename: Yunjiang
authors.initials: Y
authors.lastname: Feng
mesh_terms: D002942:Circular Dichroism; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D029909:Sophora / Q000737:chemistry*
chemical_list: D051275:Glucose Transporter Type 4
keywords: Antidiabetic; Flavone; Flavonoids; GLUT-4; Polyprenylated flavonoids; Traditional Chinese Medicine