title: Pharmacological Analysis of the Therapeutic Effect of Radioprotectors Cystamine and Indralin in the Capacity of Radiomitigators.
abstract: The therapeutic radiomitigating effect of cystamine and indralin was studied in experiments on mice and rats and pharmacological analysis of these drugs was carried out. The animals were subjected to whole-body60Co γ-irradiation. The mice were exposed to single (9-10 Gy) or double (8 Gy) irradiation with an interval of 1 month. The rats were exposed to 10 Gy with partial shielding of the upper quarter of the abdomen. In experiments on mice, pretreatment with reserpine abolished the therapeutic effect of cystamine administered repeatedly every 15 min over 1 h after irradiation. Moreover, summation of the radioprotective and therapeutic effects of the radioprotector was revealed under these conditions. In mice and rats, α1-adrenoreceptor blocker terazosin did not abolish the therapeutic effect of indralin administrated after irradiation, but blocked the radioprotective effect of indralin applied prior to irradiation. At the same time, 5-HT2serotonin receptor blocker tropoxin abolished the therapeutic effect of indralin without affecting its radioprotective activity.
authors.affiliation: Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow, Russia. mikhail-vvasin@yandex.ru.
authors.forename: M V
authors.initials: MV
authors.lastname: Vasin
authors.affiliation: Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Ushakov
authors.affiliation: Research and Development Center "Farmzaschita", the Federal Medical-Biological Agency of Russia, Khimki, Moscow Region, Russia.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Kovtun
authors.affiliation: Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow, Russia.
authors.forename: S N
authors.initials: SN
authors.lastname: Komarova
authors.affiliation: Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Semenova
authors.affiliation: Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Galkin
authors.affiliation: Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow, Russia.
authors.forename: R V
authors.initials: RV
authors.lastname: Afanas'ev
authors.affiliation: Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Bukhtiyarov
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000494:pharmacology; D000818:Animals; D001372:Aza Compounds / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology; D003538:Cystamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D004334:Drug Administration Schedule; D005260:Female; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010636:Phenols / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011224:Prazosin / Q000031:analogs & derivatives / Q000494:pharmacology; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism; D044348:Receptors, Serotonin, 5-HT2 / Q000378:metabolism; D012110:Reserpine / Q000494:pharmacology; D014916:Whole-Body Irradiation
chemical_list: C114333:3-(3,4,5-trimethoxybenzoyloximino)-8-methyl-8-azabicyclo(3,2,1)octane; D058668:Adrenergic alpha-1 Receptor Antagonists; D001372:Aza Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D010636:Phenols; D011837:Radiation-Protective Agents; D018340:Receptors, Adrenergic, alpha-1; D044348:Receptors, Serotonin, 5-HT2; C086896:indralin; D012110:Reserpine; C041226:Terazosin; D003538:Cystamine; D011224:Prazosin
keywords: cystamine; indralin; shielding; terazosin; tropoxin