title: A new and potentially prebiotic α-cytidine derivative.
abstract: A new α-cytidine derivative was synthesised from the prebiotic reaction of ribose aminooxazoline and dicyanoacetylene. The tetracyclic structure of the product was confirmed by X-ray diffraction and then an alternative 6-step synthetic pathway to the product was found which was suitable for large-scale synthesis.
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, CB2 0QH, UK. johns@mrc-lmb.cam.ac.uk.
authors.forename: Maria
authors.identifier: http://orcid.org/0000-0001-9103-991X
authors.initials: M
authors.lastname: Tsanakopoulou
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, CB2 0QH, UK. johns@mrc-lmb.cam.ac.uk.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Bond
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, CB2 0QH, UK. johns@mrc-lmb.cam.ac.uk.
authors.forename: John D
authors.initials: JD
authors.lastname: Sutherland