title: Modulation of hepatic stellate cells and reversibility of hepatic fibrosis.
abstract: Hepatic fibrosis (HF) is the pathological component of a variety of chronic liver diseases. Hepatic stellate cells (HSC) are the main collagen-producing cells in the liver and their activation promotes HF. If HSC activation and proliferation can be inhibited, HF occurrence and development can theoretically be reduced and even reversed. Over the past ten years, a number of studies have addressed this process, and here we present a review of HSC modulation and HF reversal.
authors.affiliation: Faculty of Graduate Studies of Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, PR China. Electronic address: 1293363632@QQ.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 East China Road, Nanning 530011, Guangxi Zhuang Autonomous Region, PR China. Electronic address: Hendly@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Deng
authors.affiliation: Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, PR China. Electronic address: lj99669@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Liang
mesh_terms: D000818:Animals; D017209:Apoptosis; D055166:Hepatic Stellate Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology
chemical_list: D007155:Immunologic Factors
keywords: Hepatic fibrosis; Hepatic stellate cells; Mechanism; Modulation; Reversibility