title: Involvement of Glucagon-Like Peptide-1 in the Regulation of Selective Excretion of Sodium or Chloride Ions by the Kidneys.
abstract: An increase of total glucagon-like peptide-1 (GLP-1) concentration in the plasma in rats was revealed 5 min after oral, but not intraperitoneal administration of NaCl or Trizma HCl solutions. The increase in GLP-1 level was similar to that after oral glucose administration. After intraperitoneal administration of 2.5% NaCl, GLP-1 mimetic exenatide accelerated natriuresis and urinary chloride excretion. Under conditions of normonatriemia and hyperchloremia induced by injection of 6.7% Trizma HCl, exenatide stimulated chloride excretion and reabsorption of sodium ions in the kidneys. These findings suggest that GLP-1 participates in selective regulation of the balance of sodium and chloride ions.
authors.affiliation: I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia. annamarina@bk.ru.
authors.forename: A S
authors.initials: AS
authors.lastname: Marina
authors.affiliation: I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kutina
authors.affiliation: I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Shakhmatoba
authors.affiliation: I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Natochin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002712:Chlorides / Q000652:urine*; D000077270:Exenatide; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007477:Ions; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000652:urine*; D012965:Sodium Chloride / Q000494:pharmacology; D014325:Tromethamine / Q000494:pharmacology; D014688:Venoms / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D002712:Chlorides; D007004:Hypoglycemic Agents; D007477:Ions; D010455:Peptides; D014688:Venoms; D014325:Tromethamine; D012965:Sodium Chloride; D052216:Glucagon-Like Peptide 1; D012964:Sodium; D000077270:Exenatide; D005947:Glucose
keywords: chloride ion excretion; exenatide; glucagon-like peptide-1; kidneys; sodium ion excretion