title: Therapeutic Application of Adult Stem Cells in the Heart.
abstract: Cell therapies have been explored as a potential treatment avenue to treat heart diseases, such as myocardial infarction, doxorubicin-induced cardiomyopathy, and heart failure. Embryonic and adult stem cells (ASCs) have been examined in animal and clinical settings. Unlike embryonic and induced pluripotent stem cells, ASCs do not pose a threat to form teratomas, nor do they have immune system concerns, making them ideal for therapeutic use in humans. In this review, we will investigate different characteristics and sources of adult stem cells and progenitor cells, as well as determine their efficacy in cell transplantation in experimental and clinical trials. In addition, we will propose other research avenues that may promote further understanding and use of ASCs in therapeutic designs.
authors.affiliation: Division of Metabolic and Cardiovascular Sciences, Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., Orlando, FL, USA.
authors.forename: Taylor A
authors.initials: TA
authors.lastname: Johnson
authors.affiliation: Division of Metabolic and Cardiovascular Sciences, Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., Orlando, FL, USA. dsingla@ucf.edu.
authors.forename: Dinender K
authors.initials: DK
authors.lastname: Singla
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology* / Q000378:metabolism; D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006331:Heart Diseases / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D009928:Organ Specificity; D012038:Regeneration; D044968:Regenerative Medicine; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D013552:Swine; D016896:Treatment Outcome
keywords: Adult stem cells; Cardiovascular diseases; Progenitor cells