title: The Interplay of LncRNA-H19 and Its Binding Partners in Physiological Process and Gastric Carcinogenesis.
abstract: Long non-coding RNA (lncRNA), a novel and effective modulator in carcinogenesis, has become a study hotspot in recent years. The imprinted oncofetal lncRNA H19 is one of the first identified imprinted lncRNAs with a high expression level in embryogenesis but is barely detectable in most tissues after birth. Aberrant alterations of H19 expression have been demonstrated in various tumors, including gastric cancer (GC), implicating a crucial role of H19 in cancer progression. As one of the top malignancies in the world, GC has already become a serious concern to public health with poor prognosis. The regulatory roles of H19 in gastric carcinogenesis have been explored by various research groups, which leads to the development of GC therapy. This review comprehensively summarizes the current knowledge of H19 in tumorigenesis, especially in GC pathogenesis, with emphasis on the underneath molecular mechanisms depicted from its functional partners. Furthermore, the accumulated knowledge of H19 will provide better understanding on targeted therapy of GC.
authors.affiliation: Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. li.3.zhang@uconn.edu.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. zyhjoe@gmail.com.|Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. zyhjoe@gmail.com.|Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, China. zyhjoe@gmail.com.|Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. zyhjoe@gmail.com.
authors.forename: Yuhang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. huangtingting0531@gmail.com.|Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. huangtingting0531@gmail.com.|Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, China. huangtingting0531@gmail.com.|Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. huangtingting0531@gmail.com.
authors.forename: Tingting
authors.initials: T
authors.lastname: Huang
authors.affiliation: Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. alfredcheng@cuhk.edu.hk.|Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. alfredcheng@cuhk.edu.hk.|School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China. alfredcheng@cuhk.edu.hk.
authors.forename: Alfred S L
authors.initials: AS
authors.lastname: Cheng
authors.affiliation: Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. junyu@cuhk.edu.hk.|Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. junyu@cuhk.edu.hk.|Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. junyu@cuhk.edu.hk.
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. weikang@cuhk.edu.hk.|Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. weikang@cuhk.edu.hk.|Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, China. weikang@cuhk.edu.hk.|Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. weikang@cuhk.edu.hk.
authors.forename: Wei
authors.initials: W
authors.lastname: Kang
authors.affiliation: Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. kfto@cuhk.edu.hk.|Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. kfto@cuhk.edu.hk.|Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, China. kfto@cuhk.edu.hk.|Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. kfto@cuhk.edu.hk.
authors.forename: Ka Fai
authors.initials: KF
authors.lastname: To
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism; D019175:DNA Methylation; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism
chemical_list: C094335:H19 long non-coding RNA; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D016601:RNA-Binding Proteins
keywords: H19; gastric cancer; lncRNA