title: FHL2 Regulates Natural Killer Cell Development and Activation duringStreptococcus pneumoniaeInfection.
abstract: Recentin silicostudies suggested that the transcription cofactor LIM-only protein FHL2 is a major transcriptional regulator of mouse natural killer (NK) cells. However, the expression and role of FHL2 in NK cell biology are unknown. Here, we confirm that FHL2 is expressed in both mouse and human NK cells. Using FHL2-/-mice, we found that FHL2 controls NK cell development in the bone marrow and maturation in peripheral organs. To evaluate the importance of FHL2 in NK cell activation, FHL2-/-mice were infected withStreptococcus pneumoniae. FHL2-/-mice are highly susceptible to this infection. The activation of lung NK cells is altered in FHL2-/-mice, leading to decreased IFNγ production and a loss of control of bacterial burden. Collectively, our data reveal that FHL2 is a new transcription cofactor implicated in NK cell development and activation during pulmonary bacterial infection.
authors.affiliation: INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université François Rabelais, Tours, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Baranek
authors.affiliation: INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université François Rabelais, Tours, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Morello
authors.affiliation: INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université François Rabelais, Tours, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Valayer
authors.affiliation: INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université François Rabelais, Tours, France.
authors.forename: Rose-France
authors.initials: RF
authors.lastname: Aimar
authors.affiliation: INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université François Rabelais, Tours, France.
authors.forename: Déborah
authors.initials: D
authors.lastname: Bréa
authors.affiliation: INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université François Rabelais, Tours, France.
authors.forename: Clemence
authors.initials: C
authors.lastname: Henry
authors.affiliation: INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université François Rabelais, Tours, France.
authors.forename: Anne-Gaelle
authors.initials: AG
authors.lastname: Besnard
authors.affiliation: INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université François Rabelais, Tours, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Dalloneau
authors.affiliation: INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université François Rabelais, Tours, France; Service de Réanimation Polyvalente, Centre Hospitalier Régional Universitaire, Tours, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Guillon
authors.affiliation: INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université François Rabelais, Tours, France; Service de Réanimation Polyvalente, Centre Hospitalier Régional Universitaire, Tours, France.
authors.forename: Pierre-François
authors.initials: PF
authors.lastname: Dequin
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS , Marseille , France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Narni-Mancinelli
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France; Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Vivier
authors.affiliation: ISP, INRA, Université Tours , Nouzilly , France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Laurent
authors.affiliation: Hépacivirus et immunité innée, Institut Pasteur , Paris , France.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wei
authors.affiliation: INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université François Rabelais, Tours, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Paget
authors.affiliation: INSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université François Rabelais, Tours, France.
authors.forename: Mustapha
authors.initials: M
authors.lastname: Si-Tahar
keywords: FHL2; NK cell; maturation; mouse models; pneumococcal infections; transcriptional factor