title: Association between Lp-PLA2 and coronary heart disease in Chinese patients.
abstract: Objective To evaluate the association between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2; known to release inflammatory mediators that promote atherosclerosis) and coronary heart disease (CHD) in Chinese patients. Methods This observational, cross-sectional study included a patient cohort who were assessed by coronary angiography and divided into patients with coronary heart disease and patients with normal coronary angiography (controls). Data for several biochemical indicators were collected. Plasma Lp-PLA2 concentrations were measured by enzyme-linked immunosorbent assay. Univariate and multivariate logistic regression were used to analyse the association between Lp-PLA2 concentration and CHD. Results A total of 531 patients were included, comprising 391 with CHD and 140 with normal coronary angiography (controls). Plasma Lp-PLA2 concentration was significantly higher in patients with CHD versus controls (median, 251 µg/l versus 219 µg/l, respectively), and particularly among patients with acute myocardial infarction and stable angina pectoris (249 µg/l and 266 µg/l, respectively). Multivariate analysis showed that Lp-PLA2 ≥ 292 µg/l (upper quartile of the whole cohort) was independently associated with CHD (odds ratio 2.814, 95% confidence interval 1.519, 5.214). Conclusion Plasma Lp-PLA2 concentration was independently associated with CHD in Chinese patients.
authors.affiliation: 1 Department of Cardiology, Thoracic Clinical College, Tianjin Medical University, Tianjin, China.|2 Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.affiliation: 2 Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: 2 Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
authors.forename: Shufeng
authors.initials: S
authors.lastname: Wang
authors.affiliation: 3 Tianjin Cardiovascular Institute, Tianjin Chest Hospital, Tianjin, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.affiliation: 1 Department of Cardiology, Thoracic Clinical College, Tianjin Medical University, Tianjin, China.|2 Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Cong
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood* / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060050:Angina, Stable / Q000097:blood* / Q000000981:diagnostic imaging / Q000208:ethnology / Q000503:physiopathology; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000208:ethnology / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D015870:Gene Expression; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging / Q000208:ethnology / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C526684:PLA2G7 protein, human
keywords: Lipoprotein-associated phospholipase A2; atherosclerosis; coronary heart disease