title: Statin Use and 25-Hydroxyvitamin D Blood Level Response to Vitamin D Treatment of Older Adults.
abstract: OBJECTIVE
  To determine whether statin use alters response of 25-hydroxyvitamin D (25(OH)D) level to vitamin D treatment.
  
  
  METHODS
  Pooled analysis.
  
  
  METHODS
  Three double-blind randomized controlled trials that tested different doses of vitamin D.
  
  
  METHODS
  Participants of three trials (N = 646; mean age 76.3 ± 8.4, 65% female).
  
  
  METHODS
  In all three trials, 25(OH)D status and statin use were assessed repeatedly over time (baseline, 6 and 12 months). Repeated-measures analysis was used to compare 25(OH)D response to vitamin D treatment at baseline and 6 and 12 months of statin users and nonusers, controlling for age, sex, body mass index, Charlson Comorbidity Index, vitamin D dose, trial, and season.
  
  
  RESULTS
  At baseline, 17.5% were statin users, and 65% were vitamin D deficient (25(OH)D < 20 ng/mL). Baseline 25(OH)D levels did not differ significantly between groups at baseline (18.8 for statin users, 17.2 ng/mL for nonusers, P = .07), but according to the longitudinal analyses, the total increase over 12 months in 25(OH)D concentration was significantly lower in statin users (13.1 ng/L) than nonusers (15.9 ng/mL; 21.4% difference; P = .009).
  
  
  CONCLUSIONS
  Of persons aged 60 and older at high risk of vitamin D deficiency, statin users had a 21.4% smaller increase in 25(OH)D serum concentrations over time than nonusers, independent of vitamin D dose and other covariates.
authors.affiliation: Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.|Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.
authors.forename: Heike A
authors.initials: HA
authors.lastname: Bischoff-Ferrari
authors.affiliation: Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.|Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.
authors.forename: Karina
authors.initials: K
authors.lastname: Fischer
authors.affiliation: Department of Biostatistics, School of Public Health, Harvard University, Boston, Massachusetts.
authors.forename: Endel J
authors.initials: EJ
authors.lastname: Orav
authors.affiliation: U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.
authors.forename: Bess
authors.initials: B
authors.lastname: Dawson-Hughes
authors.affiliation: Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.|Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.
authors.forename: Ursina
authors.initials: U
authors.lastname: Meyer
authors.affiliation: Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.|Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.
authors.forename: Patricia O
authors.initials: PO
authors.lastname: Chocano-Bedoya
authors.affiliation: Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.|Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.
authors.forename: Otto W
authors.initials: OW
authors.lastname: Meyer
authors.affiliation: Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.|Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.
authors.forename: Rahel
authors.initials: R
authors.lastname: Ernst
authors.affiliation: Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.|Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.
authors.forename: Simeon
authors.initials: S
authors.lastname: Schietzel
authors.affiliation: Department of Cardiology, Triemli City Hospital, Zurich, Switzerland.
authors.forename: Franz
authors.initials: F
authors.lastname: Eberli
authors.affiliation: Department of Geriatrics, University of Basel, Basel, Switzerland.
authors.forename: Hannes B
authors.initials: HB
authors.lastname: Staehelin
authors.affiliation: Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.|Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.
authors.forename: Gregor
authors.initials: G
authors.lastname: Freystätter
authors.affiliation: Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Susanne
authors.initials: S
authors.lastname: Roas
authors.affiliation: Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.|Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.
authors.forename: Robert
authors.initials: R
authors.lastname: Theiler
authors.affiliation: Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.|Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Egli
authors.affiliation: Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.|Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.
authors.forename: Nicholas M
authors.initials: NM
authors.lastname: Wilson
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014808:Vitamin D Deficiency / Q000188:drug therapy*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25-hydroxyvitamin D; older adults; statin use; vitamin D treatment