title: Innate Immune Activity in Glomerular Podocytes.
abstract: Glomerular podocytes are specialized in structure and play an essential role in glomerular filtration. In addition, podocyte stress can initiate glomerular damage by inducing the injury of other glomerular cell types. Studies have shown that podocytes possess the property of immune cells and may be involved in adaptive immunity. Emerging studies have also shown that podocytes possess signaling pathways of innate immune responses and that innate immune responses often result in podocyte injury. More recently, mitochondrial-derived damage-associated molecular patterns (mtDAMPs) have been shown to play a critical role in a variety of pathological processes in cells. In the present mini-review, we summarize the recent advances in the studies of innate immunity and its pathogenic role in podocytes, particularly, from the perspective of mtDAMPs.
authors.affiliation: National Clinical Research Center for Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China; Department of Nephrology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Xia
authors.affiliation: National Clinical Research Center for Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine , Nanjing , China.
authors.forename: Wenduona
authors.initials: W
authors.lastname: Bao
authors.affiliation: National Clinical Research Center for Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine , Nanjing , China.
authors.forename: Shaolin
authors.initials: S
authors.lastname: Shi
keywords: apoptosis; innate immunity; lupus nephropathy; mitochondrial DAMPs; podocyte injury