title: Computational Analysis of Intra-Ventricular Flow Pattern Under Partial and Full Support of BJUT-II VAD.
abstract: BACKGROUND Partial support, as a novel support mode, has been widely applied in clinical practice and widely studied. However, the precise mechanism of partial support of LVAD in the intra-ventricular flow pattern is unclear. MATERIAL AND METHODS In this study, a patient-specific left ventricular geometric model was reconstructed based on CT data. The intra-ventricular flow pattern under 3 simulated conditions - "heart failure", "partial support", and "full support" - were simulated by using fluid-structure interaction (FSI). The blood flow pattern, wall shear stress (WSS), time-average wall shear stress (TAWSS), oscillatory shear index (OSI), and relative residence time (RRT) were calculated to evaluate the hemodynamic effects. RESULTS The results demonstrate that the intra-ventricular flow pattern is significantly changed by the support level of BJUT-II VAD. The intra-ventricular vortex was enhanced under partial support and was eliminated under full support, and the high OSI and RRT regions changed from the septum wall to the cardiac apex. CONCLUSIONS In brief, the support level of the BJUT-II VAD has significant effects on the intra-ventricular flow pattern. The partial support mode of BJUT-II VAD can enhance the intra-ventricular vortex, while the distribution of high OSI and RRT moved from the septum wall to the cardiac apex. Hence, the partial support mode of BJUT-II VAD can provide more benefit for intra-ventricular flow pattern.
authors.affiliation: School of Life Sciences and BioEngineering, Beijing University of Technology, Beijing, China (mainland).
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Life Science and BioEngineering, Beijing University of Technology, Beijing, China (mainland).
authors.forename: Bin
authors.initials: B
authors.lastname: Gao
authors.affiliation: School of Life Science and BioEngineering, Beijing University of Technology, Beijing, China (mainland).
authors.forename: Yu
authors.initials: Y
authors.lastname: Chang
mesh_terms: D003198:Computer Simulation; D006321:Heart / Q000033:anatomy & histology* / Q000503:physiopathology*; D006352:Heart Ventricles / Q000033:anatomy & histology / Q000503:physiopathology; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D008955:Models, Cardiovascular; D016277:Ventricular Function, Left / Q000502:physiology