title: A two-photon fluorescent probe for real-time monitoring of autophagy by ultrasensitive detection of the change in lysosomal polarity.
abstract: The first two-photon probe, Lyso-OC, was proposed for use in monitoring cell autophagy by detection of the change in the lysosomal polarity during the membrane fusion process of autophagy. The Lyso-OC probe exhibited desirable optical properties and a detection signal that was selective to the polarity change. More importantly, Lyso-OC displayed real-time monitoring of autophagy in living cells.
authors.affiliation: Department of Chemistry, Anhui University, Hefei, Anhui 230601, China. mengxm@ahu.edu.cn.
authors.forename: Jiacheng
authors.initials: J
authors.lastname: Jiang
authors.affiliation: School of Life Sciences, Anhui University, Hefei, Anhui 230601, China.
authors.forename: Xiaohe
authors.identifier: http://orcid.org/0000-0002-2294-3945
authors.initials: X
authors.lastname: Tian
authors.affiliation: Institute of Health Sciences, Anhui University, Hefei, Anhui 230601, China.
authors.forename: Changzhi
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Chemistry, Anhui University, Hefei, Anhui 230601, China. mengxm@ahu.edu.cn.
authors.forename: Shuxin
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Anhui University, Hefei, Anhui 230601, China. mengxm@ahu.edu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Chemistry, Anhui University, Hefei, Anhui 230601, China. mengxm@ahu.edu.cn.
authors.forename: Man
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Anhui University, Hefei, Anhui 230601, China. mengxm@ahu.edu.cn.
authors.forename: Haizhu
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Chemistry, Anhui University, Hefei, Anhui 230601, China. mengxm@ahu.edu.cn.
authors.forename: Manzhou
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of Chemistry, Anhui University, Hefei, Anhui 230601, China. mengxm@ahu.edu.cn.
authors.forename: Xiangming
authors.identifier: http://orcid.org/0000-0003-3379-1868
authors.initials: X
authors.lastname: Meng