title: Metabolic syndrome causes recognition impairments and reduced hippocampal neuronal plasticity in rats.
abstract: Metabolic syndrome (MS) is a serious public health problem, which can promote neuronal alterations in cognitive regions related to learning and memory processes, such as the hippocampus. However, up to now there has been information of a regional segregation of this damage. In this study, we evaluate the MS effect on the neuronal morphology of the hippocampus. Our results demonstrate that 90days of a high-calorie diet alters the metabolic energy markers causing the MS and causes memory impairments, evaluated by the recognition of novel objects test (NORT). In addition, MS animals showed significant differences in dendritic order, total dendritic length and density of dendritic spines in CA1, CA3 and the dentate gyrus (DG) of the hippocampal area, compared with rats fed with a normocaloric diet (vehicle group). Furthermore, the immunoreactivity to synaptophysin (Syp) decreased in the hippocampus of the MS animals compared to the vehicle group. These results indicate that metabolic alterations induced by the MS affect hippocampal plasticity and hippocampal dependent memory processes.
authors.affiliation: Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, Pue., Mexico.
authors.forename: Samuel
authors.initials: S
authors.lastname: Treviño
authors.affiliation: Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, Pue., Mexico.
authors.forename: Rubén A
authors.initials: RA
authors.lastname: Vázquez-Roque
authors.affiliation: Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, Pue., Mexico.
authors.forename: Gustavo
authors.initials: G
authors.lastname: López-López
authors.affiliation: Departamento de Farmacología, Centro de Investigaciones y Estudios Avanzados, CINVESTAV, Ciudad de México, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Perez-Cruz
authors.affiliation: Departamento de Biología y Toxicología de la Reproducción, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, Pue., Mexico.
authors.forename: Carolina
authors.initials: C
authors.lastname: Moran
authors.affiliation: Departamento de Biología y Toxicología de la Reproducción, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, Pue., Mexico.
authors.forename: Anabella
authors.initials: A
authors.lastname: Handal-Silva
authors.affiliation: Centro de Química, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, Pue., Mexico.
authors.forename: Enrique
authors.initials: E
authors.lastname: González-Vergara
authors.affiliation: Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, Pue., Mexico.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Flores
authors.affiliation: Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
authors.forename: Jorge
authors.initials: J
authors.lastname: Guevara
authors.affiliation: Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, Pue., Mexico. Electronic address: alfonso.diaz@correo.buap.mx.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Díaz
mesh_terms: D000818:Animals; D005106:Exploratory Behavior / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008569:Memory Disorders / Q000378:metabolism* / Q000473:pathology / Q000523:psychology; D024821:Metabolic Syndrome / Q000378:metabolism* / Q000473:pathology / Q000523:psychology; D009473:Neuronal Plasticity / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000502:physiology*
keywords: CA1-CA3; Dendrites; Dentate gyrus; High-calorie diet; Spines; Synaptophysin