title: Use of oral fluralaner for the treatment of Psoroptes cuniculi in 15 naturally infested rabbits.
abstract: BACKGROUND
  Psoroptes cuniculi, a nonburrowing ear mite, is a common ectoparasite of rabbits. Constant irritation of the auditory canal by the presence of this mite can lead to otitis externa or otoacariasis.
  
  
  OBJECTIVE
  The goal of this study was to evaluate the effect of fluralaner on rabbits naturally infested with P. cuniculi and exhibiting clinical signs.
  
  
  METHODS
  Fifteen female New Zealand domestic rabbits with otitis due to naturally occurring infestation with P. cuniculi.
  
  
  METHODS
  The external ears and ear canals of each individual were examined; samples of otic exudate were extracted with cotton swabs and examined microscopically for identification of the ectoparasite. Each animal was treated with a single 25 mg/kg oral dose of fluralaner. The amount of otic exudate/cerumen was assessed and samples were obtained from the ears to evaluate for presence or absence of mites at 4, 8, 12, 16, 20, 40 and 90 days after receiving treatment.
  
  
  RESULTS
  Post-treatment, the amount of otic exudate decreased rapidly in all animals; by Day 12 and until the end of the study all rabbits were judged to have low amount of exudate with normally visible canals. The percentage of ears positive for P. cuniculi decreased to 13.3% of ears sampled by Day 4, and by Day 12 all rabbits were negative for the parasite.
  
  
  CONCLUSIONS
  Administration of a single oral dose of fluralaner was effective for the treatment of naturally occurring P. cuniculi infestation in rabbits during a 90 day period.
authors.affiliation: Centro Veterinario México, Calle Cincinnati #22, Benito Juárez, Cd de los Deportes, 03710, Ciudad de México, México.
authors.forename: Galia
authors.initials: G
authors.lastname: Sheinberg
authors.affiliation: Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Km. 2.5 Carretera Amecameca-Ayapango, 56900, Amecameca de Juárez, Estado de México, México.
authors.forename: Camilo
authors.initials: C
authors.lastname: Romero
authors.affiliation: Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Km. 2.5 Carretera Amecameca-Ayapango, 56900, Amecameca de Juárez, Estado de México, México.
authors.forename: Rafael
authors.initials: R
authors.lastname: Heredia
authors.affiliation: Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Km. 2.5 Carretera Amecameca-Ayapango, 56900, Amecameca de Juárez, Estado de México, México.
authors.forename: Miguel
authors.initials: M
authors.lastname: Capulin
authors.affiliation: Centro Veterinario México, Calle Cincinnati #22, Benito Juárez, Cd de los Deportes, 03710, Ciudad de México, México.
authors.forename: Enrique
authors.initials: E
authors.lastname: Yarto
authors.affiliation: Departamento de Parasitología, Instituto de Diagnóstico y Referencia Epidemiológicos, Francisco de P. Miranda #177, Col. Unidad Lomas de Plateros Delegación, Alvaro Obregón, Ciudad de México, CP. 01480, México.
authors.forename: Juan
authors.initials: J
authors.lastname: Carpio
mesh_terms: D056810:Acaricides / Q000008:administration & dosage / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D004427:Ear Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D005260:Female; D007555:Isoxazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D040042:Psoroptidae; D011817:Rabbits / Q000469:parasitology*
chemical_list: C000591860:A1443 compound; D056810:Acaricides; D007555:Isoxazoles