title: Maternal and cord blood fatty acid patterns with excessive gestational weight gain and neonatal macrosomia.
abstract: OBJECTIVE
  This study evaluated the association of maternal excessive gestational weight gain with saturated and polyunsaturated fatty acid concentrations in maternal and cord serum.
  
  
  METHODS
  We included 77 pairs of women and their newborns and classified them into three groups as follows: mothers with normal gestational weight gain and their babies with normal birth weight in group I (30 pairs), mothers with excessive gestational weight gain and their babies with normal birth weight in group II (30 pairs), and mothers with excessive gestational weight gain and their macrosomic babies in group III (17 pairs). Serum fatty acid concentrations were determined through gas chromatography-mass spectrometry.
  
  
  RESULTS
  No remarkable difference in maternal dietary intake was observed among the three groups. C16:0, C18:0, eicosapentaenoic acid, and docosahexaenoic acid concentrations were significantly higher in group III mothers than in group I mothers. Compared with group I neonates, total saturated and polyunsaturated fatty acid concentrations were significantly lower but total n-3 polyunsaturated fatty acid and docosahexaenoic acid concentrations were significantly higher in group II neonates (p<0.05). The n-6: n-3 ratio in maternal and cord serum was approximately 10:1 and 1.5:1, respectively.
  
  
  CONCLUSIONS
  Women with excessive gestational weight gain who deliver a macrocosmic neonate tend to have higher total saturated fatty acid concentrations but lower docosahexaenoic acid concentrations in their neonate cord serum. Fatty acid concentrations in maternal and cord serum are not associated with maternal dietary pattern.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China.
authors.forename: Kaiyong
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China.
authors.forename: Kui
authors.initials: K
authors.lastname: Ye
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Han
authors.affiliation: Auhui Provincial Laboratory of Population Health and Eugenics, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Auhui Provincial Laboratory of Population Health and Eugenics, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China.
authors.forename: Zhongxiu
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China.
authors.forename: Qinli
authors.initials: Q
authors.lastname: Bo
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China.
authors.forename: Chunqiu
authors.initials: C
authors.lastname: Hu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China.
authors.forename: Chuanlai
authors.initials: C
authors.lastname: Hu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China. Email: kyliu@ahmu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D000328:Adult; D004032:Diet; D004281:Docosahexaenoic Acids / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000097:blood; D005227:Fatty Acids / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005320:Fetal Macrosomia / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D015430:Weight Gain
chemical_list: D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid