title: Clinical effect of intratympanic dexamethasone injection in acute unilateral tinnitus: A prospective, placebo-controlled, multicenter study.
abstract: The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection (ITDI) in acute tinnitus of presumed cochlear origin.
  
  
  
  A prospective, randomized, placebo-controlled, double-blinded, multicenter study.
  
  
  
  Between August 2013 and December 2015, 54 patients with unilateral tinnitus were enrolled at four different centers. Patients were assigned either to an ITDI (n = 27) or an intratympanic normal saline injection (ITNI; n = 27) group through block randomization. Intratympanic injections were administered four times over 2 weeks. At 4 weeks after initial injection, we analyzed the improvement rates of tinnitus using the tinnitus handicap Inventory (THI) and visual analogue scale (VAS) for loudness, awareness, and annoyance. We defined improvement as the reduction of more than 7 points or of more than 20% in the final THI score compared to the initial THI score.
  
  
  
  The initial mean hearing thresholds and VAS and THI scores of the two groups did not differ significantly. At 4 weeks after initial injection, the mean VAS and THI scores of both groups had significantly reduced. However, the improvement rate did not differ significantly between the groups (ITDI, 51.9%; ITNI, 59.3%).
  
  
  
  The results indicate that ITDI might not be more effective than ITNI for the treatment of acute unilateral tinnitus. Therefore, ITDI should not be considered as the main treatment for patients presenting with acute tinnitus as the primary symptom.
  
  
  
  1b. Laryngoscope, 128:184-188, 2018.
authors.affiliation: Department of Otorhinolaryngology, Gyeongsang National University Changwon Hospital, Changwon, Korea.
authors.forename: Hyun-Jin
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Min-Beom
authors.initials: MB
authors.lastname: Kim
authors.affiliation: Ear and Hearing, Myung Dong Clinic, Seoul, Korea.
authors.forename: Shin-Young
authors.initials: SY
authors.lastname: Yoo
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Shi Nae
authors.initials: SN
authors.lastname: Park
authors.affiliation: Department of Otolaryngology, Kangwon National University, School of Medicine, Chuncheon, Korea.
authors.forename: Eui-Cheol
authors.initials: EC
authors.lastname: Nam
authors.affiliation: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: In Seok
authors.initials: IS
authors.lastname: Moon
authors.affiliation: Soree Ear Clinic, Seoul, Korea.
authors.forename: Ho-Ki
authors.initials: HK
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003907:Dexamethasone / Q000008:administration & dosage*; D004185:Disability Evaluation; D004311:Double-Blind Method; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D000069555:Injection, Intratympanic; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D056910:Republic of Korea; D014012:Tinnitus / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone
keywords: Intratympanic dexamethasone injection; tinnitus