title: Development of imaging biomarkers and generation of big data.
abstract: Several image processing algorithms have emerged to cover unmet clinical needs but their application to radiological routine with a clear clinical impact is still not straightforward. Moving from local to big infrastructures, such as Medical Imaging Biobanks (millions of studies), or even more, Federations of Medical Imaging Biobanks (in some cases totaling to hundreds of millions of studies) require the integration of automated pipelines for fast analysis of pooled data to extract clinically relevant conclusions, not uniquely linked to medical imaging, but in combination to other information such as genetic profiling. A general strategy for the development of imaging biomarkers and their integration in the cloud for the quantitative management and exploitation in large databases is herein presented. The proposed platform has been successfully launched and is being validated nowadays among the early adopters' community of radiologists, clinicians, and medical imaging researchers.
authors.affiliation: Biomedical Imaging Research Group (GIBI230), La Fe Health Research Institute and La Fe Polytechnics and University Hospital, Tower E, Floor 0, GIBI230 Office, Av. Fernando Abril Martorell 106, 46026, Valencia, Spain. alberich_ang@gva.es.|QUIBIM SL, Valencia, Spain. alberich_ang@gva.es.
authors.forename: Ángel
authors.identifier: http://orcid.org/0000-0002-5932-2392
authors.initials: Á
authors.lastname: Alberich-Bayarri
authors.affiliation: QUIBIM SL, Valencia, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Hernández-Navarro
authors.affiliation: Biomedical Imaging Research Group (GIBI230), La Fe Health Research Institute and La Fe Polytechnics and University Hospital, Tower E, Floor 0, GIBI230 Office, Av. Fernando Abril Martorell 106, 46026, Valencia, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Ruiz-Martínez
authors.affiliation: QUIBIM SL, Valencia, Spain.
authors.forename: Fabio
authors.initials: F
authors.lastname: García-Castro
authors.affiliation: QUIBIM SL, Valencia, Spain.
authors.forename: David
authors.initials: D
authors.lastname: García-Juan
authors.affiliation: Biomedical Imaging Research Group (GIBI230), La Fe Health Research Institute and La Fe Polytechnics and University Hospital, Tower E, Floor 0, GIBI230 Office, Av. Fernando Abril Martorell 106, 46026, Valencia, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Martí-Bonmatí
mesh_terms: D015415:Biomarkers; D057225:Data Mining; D003952:Diagnostic Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted
chemical_list: D015415:Biomarkers
keywords: Big data; Cloud; Image processing; Imaging biomarkers; Radiology; Radiomics