title: RETRACTED: Downregulation of miR-204 expression correlates with poor clinical outcome of glioma patients.
abstract: Glioma is the most common type of malignant neoplasm in the central nervous system, with high incidence and mortality rate. MicroRNAs, as a class of small noncoding RNAs, play an important role in carcinogenesis and correlate with glioma diagnosis and prognosis. In this study, we investigated the microRNA-204 (miR-204) concentration in glioma tissues and its relation to the expression of ezrin and bcl-2 mRNA, as well as its potential predictive and prognostic values in glioma. The concentrations of miR-204 were significantly lower in glioma tissues than in nontumor brain tissues and also were lower in high-grade than in low-grade gliomas (World Health Organization grades III and IV versus grades I and II). The miR-204 concentration was inversely correlated with the ezrin and bcl-2 concentrations. The miR-204 concentration was classified as high or low according to the median value, and low miR-204 correlated with higher World Health Organization grade, larger tumor, and worse Karnofsky performance score. Kaplan-Meier survival analysis demonstrated that patients with low miR-204 expression had shorter progression-free survival and overall survival than patients with high miR-204 expression. In addition, univariate and multivariate analyses showed that miR-204 expression was an independent prognostic feature of overall survival and progression-free survival. In conclusion, our study indicates that miR-204 is downregulated in glioma and may be a biomarker of poor prognosis in patients with this cancer.
authors.affiliation: Department of Neurosurgery, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, Guangdong Province, China; Department of Neurosurgery, Jinling Hospital, Clinical Medical College of Southern Medical University (Guangzhou), Nanjing 210002, Jiangsu Province, China.
authors.forename: Zhen-Nan
authors.initials: ZN
authors.lastname: Ye
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Clinical Medical College of Southern Medical University (Guangzhou), Nanjing 210002, Jiangsu Province, China.
authors.forename: Jing-Peng
authors.initials: JP
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors.forename: Ling-Yun
authors.initials: LY
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors.forename: Xiang-Sheng
authors.initials: XS
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors.forename: Zong
authors.initials: Z
authors.lastname: Zhuang
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Clinical Medical College of Southern Medical University (Guangzhou), Nanjing 210002, Jiangsu Province, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Neurosurgery of the First Affiliated Hospital, Wannan Medical College, Wuhu 241001, Anhui Province, China.
authors.forename: Ce-Gang
authors.initials: CG
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Zhongdu Hospital, Bengbu 233000, Anhui Province, China.
authors.forename: Zi-Huan
authors.initials: ZH
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors.forename: Hua-Sheng
authors.initials: HS
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Clinical Medical College of Southern Medical University (Guangzhou), Nanjing 210002, Jiangsu Province, China.
authors.forename: Wen-Zhong
authors.initials: WZ
authors.lastname: Hou
authors.affiliation: Department of Neurosurgery, Jinling Hospital, Clinical Medical College of Southern Medical University (Guangzhou), Nanjing 210002, Jiangsu Province, China. Electronic address: hang_neurosurgery@163.com.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Hang
keywords: Biomarkers; Glioma; Overall survival; Prognosis; Progression-free survival; miR-204