title: Comparison of oral dexmedetomidine versus oral midazolam as premedication to prevent emergence agitation after sevoflurane anaesthesia in paediatric patients.
abstract: OBJECTIVE
  Sevoflurane is the most often used inhalational agent in paediatric anaesthesia, but emergence agitation (EA) remains a major concern. Oral midazolam and parenteral dexmedetomidine are known to be effective in controlling EA. We attempted to elucidate whether oral dexmedetomidine is better than midazolam in controlling EA.
  
  
  METHODS
  Prospective double-blinded study involving ninety patients aged 1-10 years, undergoing elective surgeries of <2 h of expected duration under sevoflurane general anaesthesia, randomised to receive either midazolam (Group A) or dexmedetomidine (Group B) as oral premedication was carried out to record level of sedation before induction, haemodynamic parameters and recovery time. Incidence and severity of EA, post-operative pain and requirement of rescue analgesic were assessed at 0, 5, 15, 30 and 60 min postoperatively.
  
  
  RESULTS
  Data were analysed applying Student'st-test and Chi-square test using SPSS software. Mask acceptance was better in Group B (97.8% vs. 73.4%,P< 0.001). Mean arterial pressure was lower in Group B (P< 0.001) though clinically not significant. More rescue analgesic was required in Group A (5.6% vs. 0%). There was no significant difference in adverse effects. Although there was a higher incidence of EA in Group A (Aono's score 3 and 4; 40% vs. 4.4%), none of them required intervention (paediatric anaesthesia emergence delirium score >10; 0 vs. 0).
  
  
  CONCLUSIONS
  Premedication with oral dexmedetomidine provides smooth induction and recovery, reduces the EA and provides better analgesia and sedation as compared to oral midazolam.
authors.affiliation: Department of Anaesthesiology and Critical Care, K. S. Hegde Medical Academy, Nitte University, Mangaluru, Karnataka, India.
authors.forename: M Kavya
authors.initials: MK
authors.lastname: Prabhu
authors.affiliation: Department of Anaesthesiology and Critical Care, K. S. Hegde Medical Academy, Nitte University, Mangaluru, Karnataka, India.
authors.forename: Sripada G
authors.initials: SG
authors.lastname: Mehandale
keywords: Dexmedetomidine; emergence agitation; midazolam; oral premedication; sevoflurane