title: Further Evidence of Sebaceous Differentiation Uniqueness: Holocrine Secretion of Sebocytes Is a Multistep, Cell-Specific Lysosomal DNase2-Mediated Mode of Programmed Cell Death.
abstract: Holocrine secretion by sebocytes does not occur via increased cell volume, but rather from programmed DNA fragmentation and death, which differs from apoptosis. Moreover, it can be enhanced with increased rates of induced terminal sebocyte differentiation. Fischer et al. address the mode of holocrine sebocyte secretion, and they demonstrate that its mechanism differs from that of apoptosis, necroptosis, and cornification, being a multistep, cell-specific lysosomal DNase2-mediated mode of programmed cell death.
authors.affiliation: Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany. Electronic address: christos.zouboulis@klinikum-dessau.de.
authors.forename: Christos C
authors.initials: CC
authors.lastname: Zouboulis
mesh_terms: D017209:Apoptosis; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000166:cytology; D012627:Sebaceous Glands / Q000166:cytology*