title: Molecular epigenetic approach activates silent gene cluster producing dimeric bis-spiro-azaphilones in Chaetomium globosum CBS148.51.
authors.affiliation: Department of Natural Medicinal Chemistry, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Meng-Hua
authors.initials: MH
authors.lastname: Wang
authors.affiliation: Department of Natural Medicinal Chemistry, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Natural Medicinal Chemistry, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Ding
authors.affiliation: Deparment of Pharmacy, School of Biological Medicine, Beijing City University, Beijing, China.
authors.forename: Shu-Bin
authors.initials: SB
authors.lastname: Niu
authors.affiliation: Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Institute of Microbiology, Beijing, China.
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Wang
authors.affiliation: Department of Natural Medicinal Chemistry, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Yu
authors.affiliation: Syngenta, Jealott's Hill International Research Centre, Berkshire, UK.
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Gu
authors.affiliation: Department of Natural Medicinal Chemistry, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Qiu-Bo
authors.initials: QB
authors.lastname: Zhang
authors.affiliation: Department of Natural Medicinal Chemistry, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Jia-Huan
authors.initials: JH
authors.lastname: Chen
authors.affiliation: Department of Natural Medicinal Chemistry, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Jia
authors.affiliation: Department of Natural Medicinal Chemistry, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Zhong-Mei
authors.initials: ZM
authors.lastname: Zou
mesh_terms: D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002597:Chaetomium / Q000235:genetics* / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D005810:Multigene Family; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D064210:Secondary Metabolism
chemical_list: D001578:Benzopyrans; D010860:Pigments, Biological; C494154:azaphilone