title: Characteristics of type 1 and 2 CNV in exudative AMD in OCT-Angiography.
abstract: BACKGROUND
  With FA and SD-OCT, different types of CNV in exudative AMD may be differentiated: type 1 CNV (within the sub-RPE space, typically corresponding to angiographically occult CNV), type 2 CNV (within the subretinal space, typically corresponding to angiographically classic CNV) and type 3 NV (intraretinal retinal angiomatous proliferation). OCT-angiography (OCT-A) is a new method to visualize vasculature based on flow characteristics. A correlation of type 1 and 2 CNV was performed.
  
  
  METHODS
  Thirty-six eyes (17 type 1 CNV, 9 combined type 1 and 2 CNV, and 10 type 2 CNV) of 36 patients were examined by FA, SD-OCT and OCT-A. Standardized OCT-A segmentations were performed at the level of mid-choroid, choriocapillaris (CC), RPE and outer retina. On these images the size and demarcation of CNV lesions were classified: "not distinguishable", "minor" or "sharp" demarcation. Furthermore, the size of the different CNV subtypes was determined and compared.
  
  
  RESULTS
  Both types of CNV were visible in OCT-A. They could be detected on the slabs "mid-choroid", "CC" and "RPE". While type 1 CNV showed most often a minor demarcation from the surrounding vasculature, type 2 CNV showed nearly always a sharp demarcation. In addition, type 2 CNV extended into the slab "outer retina" and were much smaller than type 1 CNV.
  
  
  CONCLUSIONS
  Different types of CNV in exudative AMD can be visualized and differentiated with OCT-A. Type 1 CNV were larger with minor demarcation from the surrounding vasculature and were visible on the slab "mid-choroid", "CC" and "RPE". In contrast, type 2 CNV demonstrated a sharp demarcation from the surrounding vasculature reaching the slab "outer retina".
authors.affiliation: Department of Opthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany.
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Farecki
authors.affiliation: Department of Opthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Gutfleisch
authors.affiliation: Department of Opthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany.
authors.forename: Henrik
authors.initials: H
authors.lastname: Faatz
authors.affiliation: Department of Opthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Rothaus
authors.affiliation: Department of Opthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany.
authors.forename: Britta
authors.initials: B
authors.lastname: Heimes
authors.affiliation: Department of Opthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Spital
authors.affiliation: Department of Opthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany.
authors.forename: Albrecht
authors.initials: A
authors.lastname: Lommatzsch
authors.affiliation: Department of Opthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany. dapauleikhoff@muenster.d.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pauleikhoff
mesh_terms: D000368:Aged; D002829:Choroid / Q000098:blood supply* / Q000473:pathology; D020256:Choroidal Neovascularization / Q000175:diagnosis* / Q000209:etiology; D005122:Exudates and Transudates; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D011446:Prospective Studies; D012171:Retinal Vessels / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: Choroidal neovascularisation; Exudative AMD; FA; Imaging analysis; OCT- angiography; Type 1 choroidal neovascularisation; Type 2 choroidal neovascularisation