title: Association between beat-to-beat blood pressure variability and vascular elasticity in normal young adults during the cold pressor test.
abstract: The beat-to-beat blood pressure (BP) monitoring parameters, such as average beat-to-beat BP, BP variability (BPV), could have an influence on the vascular elasticity. This study hypothesized that the elevated beat-to-beat BPV could evoke the reduction of the vascular elasticity independent of BP levels. We measured the beat-to-beat BP recordings and total arterial compliance (TAC), which was used to assess the vascular elasticity, in 80 young healthy adults during the cold pressor test (CPT). The CPT included 3 phases: baseline phase, cold stimulus phase, recovery phase. Six parameters were used to estimate BPV. In bivariate correlation analysis, TAC showed a significant correlation with systolic BP (SBP) and diastolic BP (DBP) in the cold stimulus phase; and 4 indices of SBP variability (SBPV) were associated with TAC (r = 0.271∼0.331, P ≤ 0.015) in the recovery phase; similarly, 2 indices of DBP variability (DBPV) were also correlated with TAC (r = 0.221∼0.285, P ≤ 0.048) in the recovery phase. In multivariate regression analysis, DBPV (β = 0.229, P = 0.001) was a determinant of TAC independent of average DBP, sex, and weight. In addition, both beat-to-beat BP and BPV values increased in the cold stimulus phase (P < 0.01); whereas, the TAC decreased in the cold stimulus phase (P < 0.01). In conclusion, these data suggest that the beat-to-beat DBPV shows an independent association with the vascular elasticity in young normal adults during the CPT.
authors.affiliation: Research Center for Biomedical Information Technology, Shenzhen Institute of Advance Technology, Chinese Academic of Science Shenzhen Children Hospital Department of Neurology, Shenzhen Second People's Hospital, Futian District Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences,Shenzhen University Town, Shenzhen, China.
authors.forename: Yufa
authors.initials: Y
authors.lastname: Xia
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.forename: Zhifan
authors.initials: Z
authors.lastname: Gao
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.forename: Lijie
authors.initials: L
authors.lastname: Ren
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001158:Arteries / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination; D003080:Cold Temperature; D003430:Cross-Sectional Studies; D004548:Elasticity; D005260:Female; D006801:Humans; D008297:Male; D010812:Physical Stimulation; D013564:Sympathetic Nervous System / Q000502:physiology; D059289:Vascular Stiffness; D055815:Young Adult