title: Dermal morphological changes following salicylic acid peeling and microdermabrasion.
abstract: BACKGROUND
  Microdermabrasion and chemical peeling are popular, inexpensive, and safe methods for treatment of some skin disorders and to rejuvenate skin.
  
  
  OBJECTIVE
  To study the alterations of the dermal connective tissue following salicylic acid peeling and microdermabrasion.
  
  
  METHODS
  Twenty patients were participated in our study. All participants underwent facial salicylic acid 30% peel or microdermabrasion (10 cases in each group) weekly for 6 weeks. Punch biopsies were obtained from the clinically normal skin of the right postauricular region 1 week before treatment (control group). Other punch skin biopsies were obtained 1 week after the end of the treatments from the left postauricular area. This region was treated in a similar way to the adjacent lesional skin (treated group). We used routine histological techniques (H&E stain), special stains (Masson trichrome and orcein stains), and image analyzer to study the alterations of the dermal connective tissues.
  
  
  RESULTS
  Our study demonstrates variations in the morphological changes between the control and the treated groups, and between chemical peels and microdermabrasion. Both salicylic acid 30% and microdermabrasion were associated with thickened epidermal layer, shallow dermal papillae, dense collagen, and elastic fibers. There was a significant increase among those treated sites vs control regarding epidermal thickness and collagen thickness. Also, there was a highly statistically significant increase among those treated with salicylic acid vs microdermabrasion regarding the epidermal, collagen, and elastin thickness.
  
  
  CONCLUSIONS
  Both methods stimulate the repair process. The mechanisms underlying these variations are open for further investigations.
authors.affiliation: Faculty of Medicine, Department of Dermatology, Venereology and Andrology, Assiut University, Assiut, Egypt.
authors.forename: Amira A
authors.initials: AA
authors.lastname: Abdel-Motaleb
authors.affiliation: Faculty of Medicine, Department of Histology, Sohag University, Sohag, Egypt.
authors.forename: Eman E
authors.initials: EE
authors.lastname: Abu-Dief
authors.affiliation: Faculty of Medicine, Department of Pathology, Assiut University, Assiut, Egypt.
authors.forename: Mahmoud Ra
authors.initials: MR
authors.lastname: Hussein
mesh_terms: D001706:Biopsy; D002615:Chemexfoliation; D003094:Collagen / Q000648:ultrastructure; D003869:Dermabrasion; D020405:Dermis / Q000473:pathology*; D004547:Elastic Tissue / Q000473:pathology; D004549:Elastin / Q000648:ultrastructure; D004817:Epidermis / Q000473:pathology*; D005145:Face; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D020156:Salicylic Acid / Q000627:therapeutic use*
chemical_list: D007641:Keratolytic Agents; D003094:Collagen; D004549:Elastin; D020156:Salicylic Acid
keywords: chemical peeling; collagen fibers; elastic fibers; microdermabrasion; salicylic acid peel