title: Two Cases of Oral Somatic Delusions Ameliorated With Brain Perfusion Asymmetry: A Case Report.
abstract: BACKGROUND
  Oral cenesthopathy is the complaint of abnormal oral sensation where no underlying organic cause can be identified. It is also called oral dysesthesia or oral somatic delusion and classified as delusional disorder, somatic type. The patients with oral cenesthopathy show right > left asymmetric regional cerebral blood flow (rCBF) in the broad brain region. However, the studies scrutinizing the rCBF change before and after the successful treatment are still a few so far.
  
  
  METHODS
  We present 2 cases of oral cenesthopathy, who responded well to aripiprazole. The asymmetric rCBF patterns were attenuated after successful treatment in both cases.
  
  
  CONCLUSIONS
  We found a marked improvement of oral cenesthopathy with aripiprazole. It is suggested that right > left rCBF asymmetry in the frontal and temporal lobes and thalamus, and the dopaminergic and serotonergic dysfunctions are involved in the pathology of oral cenesthopathy.
authors.affiliation: *Psychosomatic Dentistry Clinic, Dental Hospital and Departments of †Psychiatry and Behavioral Sciences, ‡Diagnostic Radiology and Nuclear Medicine, and §Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Umezaki
authors.forename: Akihito
authors.initials: A
authors.lastname: Uezato
authors.forename: Akira
authors.initials: A
authors.lastname: Toriihara
authors.forename: Toru
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Akira
authors.initials: A
authors.lastname: Toyofuku
mesh_terms: D000368:Aged; D000068180:Aripiprazole / Q000627:therapeutic use*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003702:Delusions / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D000071896:Medically Unexplained Symptoms; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000068180:Aripiprazole