title: Chronic Deep Brain Stimulation Decreases Blood Pressure and Sympathetic Nerve Activity in a Drug- and Device-Resistant Hypertensive Patient.
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Erin L
authors.initials: EL
authors.lastname: O'Callaghan
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Emma C
authors.initials: EC
authors.lastname: Hart
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Hugh
authors.initials: H
authors.lastname: Sims-Williams
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Shazia
authors.initials: S
authors.lastname: Javed
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Amy E
authors.initials: AE
authors.lastname: Burchell
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Mark
authors.initials: M
authors.lastname: Papouchado
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Jens
authors.initials: J
authors.lastname: Tank
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Karsten
authors.initials: K
authors.lastname: Heusser
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Jens
authors.initials: J
authors.lastname: Jordan
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Jan
authors.initials: J
authors.lastname: Menne
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Hermann
authors.initials: H
authors.lastname: Haller
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Angus K
authors.initials: AK
authors.lastname: Nightingale
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).
authors.forename: Julian F R
authors.initials: JF
authors.lastname: Paton
authors.affiliation: From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.). Nik.Patel@nbt.nhs.uk.
authors.forename: Nikunj K
authors.initials: NK
authors.lastname: Patel
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D008875:Middle Aged; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D016896:Treatment Outcome