title: Glucose-Responsive Insulin Delivery by Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles.
abstract: In this chapter, we describe the preparation of glucose-responsive vesicles (GRVs) and the fabrication of GRV-loaded microneedle-array patches for insulin delivery. The GRVs were formed of hypoxia-sensitive hyaluronic acid (HS-HA), the synthesis of which is presented in detail. We also describe the procedure to evaluate the in vivo efficacy of this smart patch in a mouse model of chemically induced type 1 diabetes through transcutaneous administration.
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.|North Carolina State University, 911 Oval Dr., Campus Mailbox 7115, Raleigh, NC, 27695, USA.|Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
authors.forename: Jicheng
authors.initials: J
authors.lastname: Yu
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.|North Carolina State University, 911 Oval Dr., Campus Mailbox 7115, Raleigh, NC, 27695, USA.|Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. zgu@email.unc.edu.|North Carolina State University, 911 Oval Dr., Campus Mailbox 7115, Raleigh, NC, 27695, USA. zgu@email.unc.edu.|Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. zgu@email.unc.edu.|Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. zgu@email.unc.edu.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy; D016503:Drug Delivery Systems / Q000379:methods*; D005947:Glucose / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000138:chemical synthesis / Q000737:chemistry; D000860:Hypoxia; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008845:Microinjections / Q000379:methods*; D053835:Unilamellar Liposomes
chemical_list: D001786:Blood Glucose; D007328:Insulin; D053835:Unilamellar Liposomes; D006820:Hyaluronic Acid; D005947:Glucose
keywords: Diabetes; Drug delivery; Glucose-responsive; Hypoxia-sensitive; Microneedle