title: Association ofMTRRA66G polymorphism with cancer susceptibility: Evidence from 85 studies.
abstract: Methionine synthase reductase (MTRR) is a key regulatory enzyme involved in the folate metabolic pathway. Previous studies investigating the association ofMTRRA66G polymorphism with cancer susceptibility reported inconclusive results. We performed the current meta-analysis to obtain a more precise estimation of the possible association. Published literatures were identified from PubMed, Embase and CBM databases up to October 2016. The strength of the association between theMTRRA66G polymorphism and cancer susceptibility was assessed using odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Eighty five published studies with 32,272 cases and 37,427 controls were included in this meta-analysis. Pooled results indicated that theMTRRA66G polymorphism was associated with an increased overall cancer risk (homozygous model: OR = 1.08, 95% CI = 1.02-1.15,P= 0.009; recessive model: OR = 1.06, 95% CI = 1.00-1.12,P< 0.001 and allele comparison: OR = 1.03, 95% CI = 1.00-1.06,P< 0.001). Stratification analysis further indicated significant associations in head and neck cancer, Caucasians, Africans, and high quality studies. However, to avoid the "false-positive report", the significant findings were assessed by the false-positive report probability (FPRP) test. Interestingly, the results of FPRP test revealed that the increased risk forMTRRA66G polymorphism among Africans need further validation due to the high probabilities of false-positive results. This meta-analysis suggests that theMTRRA66G polymorphism is associated with significantly increased cancer risk, a finding that needs to be confirmed in single large studies.
authors.affiliation: The Key Laboratory of Pharmacology and Medical Molecular Biology, Medical College, Henan University of Science and Technology, Luoyang 471023, Henan, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: The Molecular Medicine Key Laboratory of Liver Injury and Repair, Medical College, Henan University of Science and Technology, Luoyang 471023, Henan, China.
authors.forename: Sanqiang
authors.initials: S
authors.lastname: Li
authors.affiliation: The Key Laboratory of Pharmacology and Medical Molecular Biology, Medical College, Henan University of Science and Technology, Luoyang 471023, Henan, China.
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.affiliation: The Key Laboratory of Pharmacology and Medical Molecular Biology, Medical College, Henan University of Science and Technology, Luoyang 471023, Henan, China.
authors.forename: Shoumin
authors.initials: S
authors.lastname: Xi
keywords: Methionine synthase reductase (MTRR); meta-analysis.; polymorphism; susceptibility