title: Effects of Therapeutic Hypothermia for Neuroprotection from the Viewpoint of Redox Regulation.
abstract: Redox regulation has recently been recognized as an important factor in acute illnesses as well as in chronic diseases. It has also become a target for neuroprotection in acute intensive care. Despite its well-known therapeutic effects, therapeutic hypothermia has recently been re-evaluated for its potential use in emergency and critical care medicine. Hypothermia is an undesirable physiological condition that can increase oxidative stress and decrease anti-oxidative potency. However, many studies have shown that under ischemia/reperfusion conditions, therapeutic hypothermia actually suppresses enhanced oxidative stress and maintains or increases anti-oxidative potency. This review provides an overview and outlook for the future of therapeutic hypothermia for neuroprotection from the perspective of redox regulation in patients with post-cardiac arrest syndrome and traumatic brain injury.
authors.affiliation: Department of Pediatrics, Okayama University School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.pv702xz5@s.okayama-u.ac.jp.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Nosaka
authors.forename: Ayumi
authors.initials: A
authors.lastname: Okada
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tsukahara
mesh_terms: D000818:Animals; D000070642:Brain Injuries, Traumatic / Q000628:therapy; D002545:Brain Ischemia / Q000628:therapy; D003422:Critical Care / Q000379:methods*; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods; D006323:Heart Arrest / Q000628:therapy; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D015227:Lipid Peroxidation; D015425:Myocardial Reperfusion / Q000009:adverse effects; D000066829:Neuroprotection / Q000502:physiology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*
keywords: intensive care; oxidative stress; post-cardiac arrest syndrome; therapeutic hypothermia; traumatic brain injury