title: HER2-Positive Neuroendocrine Breast Cancer: Case Report and Review of Literature.
abstract: BACKGROUND
  Neuroendocrine carcinoma is an uncommon histology for breast cancer.
  
  
  METHODS
  Our patient underwent right quadrantectomy for a neuroendocrine carcinoma in 1984 and had a bone relapse 30 years later. After thorough pathological and immunohistochemical analysis the diagnosis was confirmed and HER2 amplification was observed. Here we discuss the management, rationale and results of HER2-targeted therapy in advanced neuroendocrine breast carcinoma.
authors.affiliation: Department of Medical Oncology, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: Arpine
authors.initials: A
authors.lastname: Gevorgyan
authors.affiliation: Medical Oncology Unit 1, IRCCS AOU San Martino-IST, Genoa, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Bregni
authors.affiliation: Department of Medical Oncology, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Galli
authors.affiliation: Medical Oncology Unit 1, IRCCS AOU San Martino-IST, Genoa, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Zanardi
authors.affiliation: Department of Medical Oncology, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: de Braud
authors.affiliation: Department of Medical Oncology, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Di Cosimo
keywords: Breast carcinoma; Neuroendocrine carcinoma; Trastuzumab