title: Timing and outcome of stoma closure in very low birth weight infants with surgical intestinal disorders.
abstract: OBJECTIVE
  Very low birth weight infants (VLBWIs) are at risk of surgical intestinal disorders including necrotizing enterocolitis (NEC), focal intestinal perforation (FIP), and meconium-related ileus (MRI). We conducted this study to verify whether the timing of stoma closure and that of enteral nutrition establishment after stoma closure in VLBWIs differ among the most common disorders.
  
  
  METHODS
  A retrospective multicenter study was conducted at 11 institutes. We reviewed the timing of stoma closure and enteral nutrition establishment in VLBWIs who underwent stoma creation for intestinal disorders.
  
  
  RESULTS
  We reviewed the medical records of 73 infants: 21 with NEC, 24 with FIP, and 25 with MRI. The postnatal age at stoma closure was 107 (28-359) days for NEC, 97 (25-302) days for FIP, and 101 (15-264) days for MRI (p = 0.793), and the postnatal age at establishment of enteral nutrition was 129 (42-381) days for NEC, 117 (41-325) days for FIP, and 128 (25-308) days for MRI (p = 0.855). The body weights at stoma closure were 1768 (620-3869) g for NEC, 1669 (1100-3040) g for FIP, and 1632 (940-3776) g (p = 0.614) for MRI. There were no significant differences among the three groups.
  
  
  CONCLUSIONS
  The present study revealed that the time and body weights at stoma closure and the postoperative restoration of bowel function in VLBWIs did not differ among the three diseases.
authors.affiliation: Department of Surgery, Kanagawa Children's Medical Center, 2-138-4 Mutsukawa, Minami-ku, Yokohama, 232-0066, Japan. kmochizuki@kcmc.jp.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Mochizuki
authors.affiliation: Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hayakawa
authors.affiliation: Department of Pediatric Surgery, Shizuoka Children's Hospital, Shizuoka, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Urushihara
authors.affiliation: Department of Pediatric Surgery, Shizuoka Children's Hospital, Shizuoka, Japan.
authors.forename: Hiromu
authors.initials: H
authors.lastname: Miyake
authors.affiliation: Department of Pediatric Surgery, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Yokoi
authors.affiliation: Department of Neonatology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Shiraishi
authors.affiliation: Division of Neonatology, Center for Maternal-Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Hideshi
authors.initials: H
authors.lastname: Fujinaga
authors.affiliation: Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Ohashi
authors.affiliation: Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Genshiro
authors.initials: G
authors.lastname: Esumi
authors.affiliation: Department of Public Health, Osaka University Faculty of Medicine, Osaka, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Ohfuji
authors.affiliation: Department of Pediatric Surgery, Miyagi Children's Hospital, Sendai, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Amae
authors.affiliation: Department of Pediatric Surgery, Ibaraki Children's Hospital, Mito, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Yanai
authors.affiliation: Department of Pediatric Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Taizo
authors.initials: T
authors.lastname: Furukawa
authors.affiliation: Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tazuke
authors.affiliation: Department of Pediatrics, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Minagawa
authors.affiliation: Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Hiroomi
authors.initials: H
authors.lastname: Okuyama
mesh_terms: D000367:Age Factors; D001835:Body Weight; D004750:Enteral Nutrition; D020345:Enterocolitis, Necrotizing / Q000601:surgery*; D005260:Female; D006801:Humans; D045823:Ileus / Q000601:surgery*; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007416:Intestinal Perforation / Q000601:surgery*; D008297:Male; D008470:Meconium; D015337:Multicenter Studies as Topic; D012189:Retrospective Studies; D012306:Risk; D054047:Surgical Stomas; D013997:Time Factors; D016896:Treatment Outcome
keywords: Focal intestinal perforation; Meconium-related ileus; Necrotizing enterocolitis; Stoma closure; Very low birth weight infants