title: Overexpression of junctional adhesion molecule-A and EphB2 predicts poor survival in lung adenocarcinoma patients.
abstract: Junctional adhesion molecules are important components of tight junctions, and Eph/ephrin proteins constitute the largest family of receptor tyrosine kinases. Both junctional adhesion molecules and Eph/ephrin are involved in normal tissue development and cancer progression. However, the expression levels and clinical significances of junctional adhesion molecule-A, a member of junctional adhesion molecules, and EphB2, a member of Eph/ephrin family, in lung adenocarcinoma patients are unclear. Therefore, in this study, we aimed to identify the expression and prognostic values of junctional adhesion molecule-A and EphB2 in lung adenocarcinoma patients' cohort. In our study, 70 (55.6%) showed high expression of junctional adhesion molecule-A protein and 51 (40.5%) showed high expression of EphB2 protein in 126 lung adenocarcinoma tissues. Junctional adhesion molecule-A and EphB2 expressions were both significantly increased in tumor tissues compared with noncancerous lung tissues. Kaplan-Meier analysis and log-rank test indicated that low expression of junctional adhesion molecule-A and EphB2 proteins can predict better survival and low mortality rate of lung adenocarcinomas. In univariate analysis, high expression levels of junctional adhesion molecule-A and EphB2 were both found to be significantly correlated with poor overall survival of lung adenocarcinoma patients (hazard ratio = 1.791, 95% confidence interval = 1.041-3.084, p = 0.035; hazard ratio = 1.762, 95% confidence interval = 1.038-2.992, p = 0.036, respectively). The multivariate Cox proportional hazard model demonstrated that EphB2 expression is an independent prognosis parameter in lung adenocarcinoma patients (hazard ratio = 1.738, 95% confidence interval = 1.023-2.952, p = 0.016). Taken together, high expression of junctional adhesion molecule-A and EphB2 can predict poor overall survival and high mortality rate, and EphB2 is an independent prognostic biomarker in lung adenocarcinoma patients.
authors.affiliation: 1 Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P.R. China.|2 Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, P.R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhao
authors.affiliation: 3 Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China.
authors.forename: Aili
authors.initials: A
authors.lastname: Wang
authors.affiliation: 1 Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P.R. China.
authors.forename: Funian
authors.initials: F
authors.lastname: Lu
authors.affiliation: 1 Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P.R. China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Chen
authors.affiliation: 1 Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P.R. China.
authors.forename: Pin
authors.initials: P
authors.lastname: Fu
authors.affiliation: 1 Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P.R. China.
authors.forename: Xianda
authors.initials: X
authors.lastname: Zhao
authors.affiliation: 1 Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P.R. China.
authors.forename: Honglei
authors.initials: H
authors.lastname: Chen
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D036183:Receptor, EphB2 / Q000096:biosynthesis*; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C407243:F11R protein, human; D011956:Receptors, Cell Surface; C586310:EPHB2 protein, human; D036183:Receptor, EphB2
keywords: B-type Eph receptor 2; Lung adenocarcinoma; junctional adhesion molecule-A; prognosis; quantum dots