title: FKBP5 genotype and early life stress exposure predict neurobehavioral outcomes for preterm infants.
abstract: This study evaluated the relationship between stressful early life neonatal intensive care unit (NICU) experiences, genetic variation of a stress response-associated gene (FKBP5), and neurobehavioral outcomes.
  
  
  
  The impact of genetic variation and stress experience on neurobehavioral outcomes was examined for 41 preterm infants. Statistical analyses explored the main effects of FKBP5 genotype and NICU stress experience, as well as their interaction on infant neurobehavioral development prior to discharge.
  
  
  
  Statistical analyses demonstrated a relationship between both FKPB5 genotype and stress related to NICU care that were independently associated with neurobehavioral outcomes; indicating a main effect of genotype and a main effect of stress on neurodevelopment. Additionally, we found an interaction between the minor allele genotype and NICU stress potentially associated with less favorable developmental progress at discharge.
  
  
  
  Evidence of genetic and environmental risk factors for neurodevelopmental impairment suggests the need for improved evidence-based practice initiatives to protect those most vulnerable to the combination of genetic susceptibility to stress and medical fragility.
authors.affiliation: School of Nursing, University of Connecticut, Storrs, Connecticut.|College of Nursing, University of South Florida, Tampa, Florida.
authors.forename: Amy L
authors.identifier: 0000-0002-9536-950X
authors.initials: AL
authors.lastname: D'Agata
authors.affiliation: School of Nursing, University of Connecticut, Storrs, Connecticut.
authors.forename: Stephen
authors.initials: S
authors.lastname: Walsh
authors.affiliation: School of Nursing, University of Connecticut, Storrs, Connecticut.|Division of Quality Management, Connecticut Department of Developmental Services, Hartford, Connecticut.
authors.forename: Dorothy
authors.initials: D
authors.lastname: Vittner
authors.affiliation: School of Nursing, University of Connecticut, Storrs, Connecticut.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Cong
authors.affiliation: School of Nursing, University of Connecticut, Storrs, Connecticut.|Connecticut Children's Medical Center, Hartford, Connecticut.
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: McGrath
authors.affiliation: School of Nursing, University of Connecticut, Storrs, Connecticut.|Institute for Systems Genomics, University of Connecticut, Storrs, Connecticut.|School of Medicine, Genetics and Genome Sciences, University of Connecticut, Farmington, Connecticut.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Young
mesh_terms: D002657:Child Development / Q000502:physiology*; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D018730:Infant Behavior / Q000502:physiology*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007363:Intensive Care Units, Neonatal; D008297:Male; D013315:Stress, Psychological; D022021:Tacrolimus Binding Proteins / Q000235:genetics*; D000099159:Tacrolimus Binding Protein 5
chemical_list: D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5
keywords: FKBP5; NICU; early life experience; genotype; neurodevelopment; prematurity; stress