title: Association of IGF1 gene polymorphism with Parkinson's disease in a Han Chinese population.
abstract: BACKGROUND
  Accumulating evidence suggests that insulin-like growth factor 1 (IGF1) plays an important role in Parkinson's disease (PD) pathogenesis. However, it is not clear whether IGF1 polymorphism contributes to PD risk.
  
  
  METHODS
  We performed a case-control study in a Han Chinese population that included 512 sporadic PD cases and 535 matched controls. All participants were genotyped for rs972936 using the Sequenom MassARRAY iPLEX platform. Serum IGF1 levels of 61 de novo, drug-naïve PD patients and 55 age- and sex-matched controls were also measured using an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Genotype frequency of rs972936-CC was significantly associated with an increased PD risk (p = 0.009), especially in males (p = 0.024) and late-onset patients (p = 0.013). Serum IGF1 levels were significantly increased in de novo, drug-naïve PD patients compared to controls (p = 0.036), although they were not correlated with motor dysfunction in PD patients (p = 0.220).
  
  
  CONCLUSIONS
  The present study shows that rs972936 polymorphism may increase susceptibility to PD, especially in males and late-onset patients. Furthermore, high serum IGF1 levels may be a potential diagnostic biomarker for PD in the Han Chinese population, although they do not correlate with a more severe motor dysfunction.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.|Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Yousheng
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.|Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Luan
authors.initials: L
authors.lastname: Cen
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.|Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Mingshu
authors.initials: M
authors.lastname: Mo
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Shuxuan
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wei
authors.affiliation: Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Shaomin
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Xinling
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Blood Transfusion, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Shaogang
authors.initials: S
authors.lastname: Qu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Pei
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.|Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Pingyi
authors.initials: P
authors.lastname: Xu
mesh_terms: D017668:Age of Onset; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D015415:Biomarkers; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011159:Population Surveillance
chemical_list: D015415:Biomarkers; D007334:Insulin-Like Growth Factor I
keywords: Parkinson's disease; gene polymorphism; insulin-like growth factor 1; rs972936