title: The correlation between transcutaneous oxygen tension and microvascular complications in type 2 diabetic patients.
abstract: OBJECTIVE
  This study aimed to assess whether transcutaneous oxygen tension (TcPO2) was associated with the presence of microvascular complications in type 2 diabetic (T2D) patients and whether TcPO2could act as an independent risk factor for predicting the occurrence of microvascular events in these patients.
  
  
  METHODS
  We recruited 436 patients with T2D. Based on the presence of diabetic kidney disease, diabetic retinopathy, and/or diabetic peripheral neuropathy, the patients were divided into groups with and without microvascular complications. The differences between these 2 groups were examined using the chi-square test and the t test. The influencing factors of diabetic microangiopathy were studied using a logistic regression analysis.
  
  
  RESULTS
  The results showed that sex, diabetes duration, smoking history, TcPO2, and HbA1c were independent risk factors for the occurrence of diabetic microvascular events (P<0.05). In particular, the risk of developing microvascular complications was 10.16 times higher in patients with low TcPO2than that in those with high TcPO2(OR=10.157, 95% CI: 4.602-22.418).
  
  
  CONCLUSIONS
  This study showed that TcPO2was significantly negatively associated with the occurrence of microvascular events in type 2 diabetic patients and that TcPO2may be an independent risk factor for predicting the occurrence of microvascular complications in these patients. These results suggest that for type 2 diabetes mellitus with clinically reduced TcPO2, we should pay close attention to the occurrence of microvascular complications and engage in early prevention.
authors.affiliation: The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China, 471003.
authors.forename: Ke
authors.initials: K
authors.lastname: Huang
authors.affiliation: The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China, 471003.
authors.forename: Yujin
authors.initials: Y
authors.lastname: Ma
authors.affiliation: The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China, 471003.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: The 150th Central Hospital of PLA, Luoyang, China.
authors.forename: Shousen
authors.initials: S
authors.lastname: Shi
authors.affiliation: The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China, 471003.
authors.forename: Liujun
authors.initials: L
authors.lastname: Fu
authors.affiliation: The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China, 471003.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China, 471003.
authors.forename: Liping
authors.initials: L
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China, 471003.
authors.forename: Haibo
authors.initials: H
authors.lastname: Lu
authors.affiliation: The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China, 471003.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liang
authors.affiliation: The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China, 471003.
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China, 471003. Electronic address: jianghw@haust.edu.cn.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D001785:Blood Gas Monitoring, Transcutaneous; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D000860:Hypoxia / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D015994:Incidence; D016015:Logistic Models; D008297:Male; D055806:Microvessels / Q000503:physiopathology*; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012737:Sex Factors; D000073869:Tobacco Smoking / Q000009:adverse effects
keywords: Microvascular complications; Risk factors; Toe-brachial index; Transcutaneous oxygen tension; Type 2 diabetes