title: Effect of Polypeptides on Cell Proliferation and Apoptosis during Aging.
abstract: Polypeptide complexes derived from the bronchi, blood vessels, muscles, kidneys, ovaries, testes, and retina stimulated the processes of cell renewal in organotypic cultures of the corresponding organs of young and old animals. A correlation between the intensity of regeneration and animal' age was revealed. The polypeptide complexes reduced the expression of apoptotic factors p53 and caspase 3 and increased the expression of proliferation protein Ki-67. These results provide the basis for further study of the polypeptide complexes as stimulators of regenerative processes in different tissues during ageing.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
authors.forename: A P
authors.initials: AP
authors.lastname: Ryzhak
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.|I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Chalisova
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. miayy@yandex.ru.|I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. miayy@yandex.ru.|Peter the Great St.Petersburg Polytechnic University, St. Petersburg, Russia. miayy@yandex.ru.
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: T E
authors.initials: TE
authors.lastname: Nichik
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Dudkov
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Kolchina
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
authors.forename: G A
authors.initials: GA
authors.lastname: Ryzhak
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
authors.forename: R I
authors.initials: RI
authors.lastname: Khalimov
mesh_terms: D000375:Aging / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001808:Blood Vessels / Q000737:chemistry / Q000166:cytology; D001980:Bronchi / Q000737:chemistry / Q000166:cytology; D053148:Caspase 3 / Q000235:genetics / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D005786:Gene Expression Regulation; D019394:Ki-67 Antigen / Q000235:genetics / Q000378:metabolism; D007668:Kidney / Q000737:chemistry / Q000166:cytology; D008297:Male; D009132:Muscles / Q000737:chemistry / Q000166:cytology; D009928:Organ Specificity; D010053:Ovary / Q000737:chemistry / Q000166:cytology; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000737:chemistry / Q000166:cytology; D013737:Testis / Q000737:chemistry / Q000166:cytology; D046509:Tissue Culture Techniques; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D019394:Ki-67 Antigen; D010455:Peptides; D016159:Tumor Suppressor Protein p53; C505407:CASP3 protein, human; D053148:Caspase 3
keywords: aging; immunocitochemistry; organotypic culture; polypeptide complex