title: Muscle Stem Cells: A Model System for Adult Stem Cell Biology.
abstract: Skeletal muscle stem cells, originally termed satellite cells for their position adjacent to differentiated muscle fibers, are absolutely required for the process of skeletal muscle repair and regeneration. In the last decade, satellite cells have become one of the most studied adult stem cell systems and have emerged as a standard model not only in the field of stem cell-driven tissue regeneration but also in stem cell dysfunction and aging. Here, we provide background in the field and discuss recent advances in our understanding of muscle stem cell function and dysfunction, particularly in the case of aging, and the potential involvement of muscle stem cells in genetic diseases such as the muscular dystrophies.
authors.affiliation: Division of Biological Sciences and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, USA. cornelisond@missouri.edu.
authors.forename: Ddw
authors.initials: D
authors.lastname: Cornelison
authors.affiliation: Cell Biology Group, Department of Experimental and Health Sciences (DCEXS), Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), 08003, Barcelona, Spain. eusebio.perdiguero@upf.edu.
authors.forename: Eusebio
authors.initials: E
authors.lastname: Perdiguero
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000502:physiology; D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation; D016922:Cellular Senescence / Q000235:genetics; D006801:Humans; D018482:Muscle, Skeletal / Q000166:cytology*; D009136:Muscular Dystrophies / Q000209:etiology / Q000378:metabolism; D010641:Phenotype; D012038:Regeneration; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*
chemical_list: D015415:Biomarkers
keywords: Aging; Heterogeneity; Muscle regeneration; Muscular dystrophies; Skeletal muscle; Stem cells