title: New arbutin derivatives from the leaves of Heliciopsis lobata with cytotoxicity.
abstract: Heliciopsis lobata is a medicinal plant, which is exclusively used to treat tumor in Li folk region. Two new arbutin derivatives, 6'-((E)2-methoxy-5-hydroxycinnamoyl) arbutin (1) and 2'-((E)2, 5-dihydroxycinnamoyl) arbutin (2) along with five known compounds (3-7), were isolated from the leaves of Heliciopsis lobata. Their structures were elucidated on the basis of extensive spectroscopic interpretations. They were evaluated for their potential anticancer activity. Compounds 6 and 7 exhibited cytotoxicity against MGC-803 cells with IC50values being 44.1 and 11.3 μg·mL-1, respectively. Additionally, compounds 1, 2 and 5-7 exhibited a moderate inhibition of MGC-803 cells invasion; compound 2 at 20 μg·mL-1inhibited the invasion of MGC-803 cells by 43.0%, compared with the controls.
authors.affiliation: Department of Marine Pharmacy, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Wei-Yan
authors.initials: WY
authors.lastname: Qi
authors.affiliation: Department of Marine Pharmacy, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Na
authors.initials: N
authors.lastname: Ou
authors.affiliation: Department of Marine Pharmacy, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Wu
authors.affiliation: Department of Marine Pharmacy, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: 13913925346@126.com.
authors.forename: Han-Mei
authors.initials: HM
authors.lastname: Xu
mesh_terms: D001104:Arbutin / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D039105:Proteaceae / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D001104:Arbutin
keywords: Anticancer effects; Arbutin; Heliciopsis lobata; Invasion