title: Systems biology of oxygen homeostasis.
abstract: Metazoan species maintain oxygen homeostasis through the activity of hypoxia-inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O2supply and demand. Here, we review the involvement of hypoxia-inducible factors in the molecular physiology and pathophysiology of cellular O2sensing, O2delivery, O2utilization, and systemic O2sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1002/wsbm.1382 For further resources related to this article, please visit the WIREs website.
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.|Johns Hopkins Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Debangshu
authors.initials: D
authors.lastname: Samanta
authors.affiliation: Institute for Integrative Physiology, Biological Sciences Division, University of Chicago, Chicago, IL, USA.|Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, IL, USA.
authors.forename: Nanduri R
authors.initials: NR
authors.lastname: Prabhakar
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.|Johns Hopkins Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.|Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.|Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.|Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.|Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.|Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Gregg L
authors.identifier: 0000-0002-0913-211X
authors.initials: GL
authors.lastname: Semenza
mesh_terms: D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D010100:Oxygen / Q000378:metabolism*; D049490:Systems Biology
chemical_list: D010100:Oxygen