title: Immunogenesis in White Mice Infected with Yersinia pestis with Different Plasmid Composition.
abstract: Morphological changes in the immunocompetent organs of white mice with experimental plague infection manifested in activation of the immune response of different degree and pathological process of different severity that depended on the plasmid composition of Y. pestis. Widening of the T-dependent zones in the immune organs of white mice infected with isogenic strains of Y. pestis with different plasmid composition attests to activation of cellular immunity. Our findings allow considering Y. pestis subsp. altaica I-2948/3, Y. pestis subsp. pestis I-3479 and Y. pestis subsp. pestis I-3480 as promising candidates for vaccine strains.
authors.affiliation: Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers' Rights Protection and Human Welfare, Irkutsk, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Balakhonov
authors.affiliation: Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers' Rights Protection and Human Welfare, Irkutsk, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Vityazeva
authors.affiliation: Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers' Rights Protection and Human Welfare, Irkutsk, Russia. dubrovina-valya@mail.ru.
authors.forename: V I
authors.initials: VI
authors.lastname: Dubrovina
authors.affiliation: Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers' Rights Protection and Human Welfare, Irkutsk, Russia.
authors.forename: T P
authors.initials: TP
authors.lastname: Starovoitova
authors.affiliation: Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers' Rights Protection and Human Welfare, Irkutsk, Russia.
authors.forename: G B
authors.initials: GB
authors.lastname: Mukhturgin
authors.affiliation: Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers' Rights Protection and Human Welfare, Irkutsk, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Ivanova
authors.affiliation: Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers' Rights Protection and Human Welfare, Irkutsk, Russia.
authors.forename: K M
authors.initials: KM
authors.lastname: Korytov
authors.affiliation: Research Center of Family Health Problems and Human Reproduction, Irkutsk, Russia.
authors.forename: S I
authors.initials: SI
authors.lastname: Kolesnikov
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D008198:Lymph Nodes / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D051379:Mice; D010930:Plague / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D010950:Plasma Cells / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D010957:Plasmids / Q000276:immunology* / Q000378:metabolism; D013045:Species Specificity; D013154:Spleen / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D014774:Virulence; D015010:Yersinia pestis / Q000276:immunology / Q000472:pathogenicity*
keywords: Yersinia pestis; experimental animals; immunocompetent organs; plasmids