title: Comparative analysis of curative effect of bone marrow mesenchymal stem cell and bone marrow mononuclear cell transplantation for spastic cerebral palsy.
abstract: Bone marrow mesenchymal stem cells (BMMSCs) and bone marrow mononuclear cells (BMMNCs) are both used to treat spastic cerebral palsy. However, the differences in therapeutic effect remain unknown.
  
  
  
  A total of 105 patients with spastic cerebral palsy were enrolled and randomly assigned to three groups: the BMMSC group, the BMMNC group and the control group. Patients in both transplantation groups received four intrathecal cell injections. Patients in the control group received Bobath therapy. The gross motor function measure (GMFM) and the fine motor function measure (FMFM) were used to evaluate the therapeutic efficacy before transplantation and 3, 6, and 12 months after transplantation.
  
  
  
  Three months after cell transplantation, scores in the A dimension of GMFM and the A and C dimensions of FMFM scores in the BMMSC group are all higher than those of the BMMNC and the control groups (P < 0.05). Six months after cell transplantation, scores in the A, B dimensions of GMFM and the A, B, C, D, and E dimensions of FMFM scores in the BMMSC group are higher than those of the BMMNC and the control groups (P < 0.05). Twelve months after cell transplantation, scores in the A, B, and C dimensions of GMFM and the A, B, C, D, and E dimensions of FMFM scores in the BMMSC group are all higher than those of the BMMNC and the control groups (P < 0.05). No obvious adverse effects were investigated during follow-up.
  
  
  
  BMMSC transplantation for the treatment of cerebral palsy is safe and feasible, and can improve gross motor and fine motor function significantly. In addition, compared with BMMNC, the motor function of children improved significantly in terms of gross motor and fine motor functions.
authors.affiliation: Department of Cell Transplantation, General Hospital of Chinese people's Armed Police Forces, Beijing, 100039, China.
authors.forename: Xuebin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Cell Transplantation, General Hospital of Chinese people's Armed Police Forces, Beijing, 100039, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Fu
authors.affiliation: Department of Cell Transplantation, General Hospital of Chinese people's Armed Police Forces, Beijing, 100039, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Dai
authors.affiliation: Department of Cell Transplantation, General Hospital of Chinese people's Armed Police Forces, Beijing, 100039, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cell Transplantation, General Hospital of Chinese people's Armed Police Forces, Beijing, 100039, China.
authors.forename: Zan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Cell Transplantation, General Hospital of Chinese people's Armed Police Forces, Beijing, 100039, China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Department of Cell Transplantation, General Hospital of Chinese people's Armed Police Forces, Beijing, 100039, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Zheng
authors.affiliation: Department of Cell Transplantation, General Hospital of Chinese people's Armed Police Forces, Beijing, 100039, China. doctoran2010@hotmail.com.
authors.forename: Yihua
authors.initials: Y
authors.lastname: An
mesh_terms: D002547:Cerebral Palsy / Q000503:physiopathology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007963:Leukocytes, Mononuclear / Q000637:transplantation*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D009043:Motor Activity
keywords: Bone marrow mesenchymal stem cells; Bone marrow mononuclear cells; Spastic cerebral palsy