title: Catalytic Asymmetric Chlorocyclization of 2-Vinylphenylcarbamates for Synthesis of 1,4-Dihydro-2H-3,1-benzoxazin-2-one Derivatives.
abstract: A facile synthetic approach to a series of chiral 4-chloromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one derivatives has been described. This transformation is achieved through the catalytic asymmetric chlorocyclization of 2-vinylphenylcarbamates using a newly developed organocatalyst. Furthermore, the resulting products can be easily converted into diverse bioactive agents.
authors.affiliation: School of Pharmaceutical Science and Technology, Key Laboratory for Modern Drug Delivery & High-Efficiency, Tianjin University , Tianjin 300072, China.
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Yu
authors.affiliation: School of Pharmaceutical Science and Technology, Key Laboratory for Modern Drug Delivery & High-Efficiency, Tianjin University , Tianjin 300072, China.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Huang
authors.affiliation: School of Pharmaceutical Science and Technology, Key Laboratory for Modern Drug Delivery & High-Efficiency, Tianjin University , Tianjin 300072, China.|School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, China.
authors.forename: Jun
authors.identifier: 0000-0002-6547-0244
authors.initials: J
authors.lastname: Deng