title: Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome.
abstract: Postfinasteride syndrome (PFS) is a term recently coined to characterize a constellation of reported undesirable side effects described in postmarketing reports and small uncontrolled studies that developed during or after stopping finasteride treatment, and persisted after drug discontinuation. Symptoms included decreased libido, erectile dysfunction, sexual anhedonia, decreased sperm count, gynecomastia, skin changes, cognitive impairment, fatigue, anxiety, depression, and suicidal ideation. The aim of this study is to review the existing medical literature for evidence-based research of permanent sexual dysfunction and mood changes during treatment with 5-alpha-reductase inhibitors including finasteride and dutasteride.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Fla, USA.
authors.forename: Raymond
authors.initials: R
authors.lastname: Fertig
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, N.Y., USA.
authors.forename: Jerry
authors.initials: J
authors.lastname: Shapiro
authors.affiliation: Departments of Dermatopathology Fellowship, Cleveland Clinic, Cleveland, Ohio, USA; Departments of Pathology, Dermatopathology Fellowship, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Wilma
authors.initials: W
authors.lastname: Bergfeld
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Fla, USA.
authors.forename: Antonella
authors.initials: A
authors.lastname: Tosti
keywords: Dutasteride; Finasteride; Permanent sexual dysfunction; Physical adverse effects; Psyche; Psychiatric adverse effects; Side effects