title: Expression of erythropoietin and neuroendocrine markers in clear cell renal cell carcinoma.
abstract: The aim of the study was to investigate the expression of erythropoietin and neuroendocrine markers in clear cell renal cell carcinoma (CCRCC). We retrospectively reviewed the medical records and re-evaluated histopathological specimens of 33 patients with CCRCC and compared with those of 11 cases of non-CCRCC. All patients were treated with a partial or radical nephrectomy at St. Olavs Hospital, Trondheim University Hospital, between 2010 and 2016. Thirty-three patients who were diagnosed with CCRCC had a total of 35 tumours, where 34 of the tumours were CCRCC and one was papillary adenoma. Thirty-three (97%) of 34 CCRCCs were positive for erythropoietin, and the same 33 (97%) tumours demonstrated strong expression for neuron-specific enolase (NSE). Two (6%) of 34 CCRCCs had a positive reaction for synaptophysin, and three (9%) of 34 were positive for CD56. Erythropoietin and NSE were negative in non-CCRCCs, and chromogranin A was negative in all tumours. The above findings suggest that there is a strong association between CCRCC and the expression of erythropoietin and NSE.
authors.affiliation: Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.|Department of Pathology and Medical Genetics, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Patricia G
authors.initials: PG
authors.lastname: Mjønes
authors.affiliation: Department of Pathology and Medical Genetics, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.|Department of Laboratory Medicine, Children's and Woman's Health, NTNU, Trondheim, Norway.
authors.forename: Ivar S
authors.initials: IS
authors.lastname: Nordrum
authors.affiliation: Department of Gastroenterology and Hepatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Qvigstad
authors.affiliation: Department of Gastroenterology and Hepatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Øystein
authors.initials: Ø
authors.lastname: Sørdal
authors.affiliation: Department of Urology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Liselotte Linnea Mårtensson
authors.initials: LL
authors.lastname: Rian
authors.affiliation: Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.|Department of Gastroenterology and Hepatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Helge L
authors.initials: HL
authors.lastname: Waldum
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D019002:CD56 Antigen / Q000032:analysis / Q000096:biosynthesis; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology*; D004921:Erythropoietin / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis / Q000096:biosynthesis; D012189:Retrospective Studies; D016708:Synaptophysin / Q000032:analysis / Q000096:biosynthesis
chemical_list: D014408:Biomarkers, Tumor; D019002:CD56 Antigen; C554270:EPO protein, human; C522918:NCAM1 protein, human; C569014:SYP protein, human; D016708:Synaptophysin; D004921:Erythropoietin; D010751:Phosphopyruvate Hydratase
keywords: Erythropoietin; chromogranin; clear cell renal cell carcinoma; neuron-specific enolase; synaptophysin