title: Surfactant-stripped naphthalocyanines for multimodal tumor theranostics with upconversion guidance cream.
abstract: Surfactant-stripped, nanoformulated naphthalocyanines (nanonaps) can be formed with Pluronic F127 and low temperature membrane processing, resulting in dispersed frozen micelles with extreme contrast in the near infrared region. Here, we demonstrate that nanonaps can be used for multifunctional cancer theranostics. This includes lymphatic mapping and whole tumor photoacoustic imaging following intradermal or intravenous injection in rodents. Without further modification, pre-formed nanonaps were used for positron emission tomography and passively accumulated in subcutaneous murine tumors. Because the nanonaps used absorb light beyond the visible range, a topical upconversion skin cream was developed for anti-tumor photothermal therapy with laser placement that can be guided by the naked eye.
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu and Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
authors.forename: Yumiao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center for Molecular Imaging, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Hao
authors.initials: H
authors.lastname: Hong
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu and Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
authors.forename: Boyang
authors.initials: B
authors.lastname: Sun
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu.
authors.forename: Kevin
authors.initials: K
authors.lastname: Carter
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu.
authors.forename: Yiru
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Institute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu.
authors.forename: Depeng
authors.initials: D
authors.lastname: Wang
authors.affiliation: School of Electronics Engineering, College of IT Engineering, Kyungpook National University, 702701, Korea.
authors.forename: Mansik
authors.initials: M
authors.lastname: Jeon
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu.
authors.forename: Jumin
authors.initials: J
authors.lastname: Geng
authors.affiliation: Department of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Nickles
authors.affiliation: Institute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA and School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150001, People's Republic of China.
authors.forename: Guanying
authors.identifier: http://orcid.org/0000-0002-4789-1176
authors.initials: G
authors.lastname: Chen
authors.affiliation: Institute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
authors.forename: Paras N
authors.initials: PN
authors.lastname: Prasad
authors.affiliation: Creative IT Engineering, Pohang University of Science and Technology, 790784, Korea.
authors.forename: Chulhong
authors.initials: C
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu.
authors.forename: Jun
authors.initials: J
authors.lastname: Xia
authors.affiliation: Department of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
authors.forename: Weibo
authors.initials: W
authors.lastname: Cai
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu and Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
authors.forename: Jonathan F
authors.identifier: http://orcid.org/0000-0002-9052-884X
authors.initials: JF
authors.lastname: Lovell
mesh_terms: D000818:Animals; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D053758:Nanoparticles; D009374:Neoplasms, Experimental / Q000628:therapy*; D010789:Phototherapy; D013501:Surface-Active Agents; D000068936:Theranostic Nanomedicine; D014018:Tissue Distribution
chemical_list: D013501:Surface-Active Agents