title: Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)-The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules.
abstract: Several novel methods, catalysts and reagents have been developed to improve organic synthesis. Synergistic effects between reactions, reagents and catalysts can lead to minor heats of reaction and occur as an inherent result of multicomponent reactions (MCRs) and their extensions. They enable syntheses to be performed at a low energy level and the number of synthesis steps to be drastically reduced in comparison with 'classical' two-component reactions, fulfilling the rules ofGreen Chemistry. The very high potential for variability, diversity and complexity of MCRs additionally generates an extremely diverse range of products, thus bringing us closer to the aim of being able to produce tailor-madeandextremely low-cost materials, drugs and compound libraries.
authors.affiliation: Department Chemie, Technische Universität München, Lichtenbergstr. 4, Garching 85747, Germany. eckert@tum.de.
authors.forename: Heiner
authors.initials: H
authors.lastname: Eckert
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009930:Organic Chemicals; D004364:Pharmaceutical Preparations
keywords: MCR; MFCR; complexity; diversity; efficiency of synthesis; multicomponents; multifunction catalysis; post condensation modification/cyclisation PCM/PCC; variability