title: Is a split-dose regimen of 2 L polyethylene glycol plus ascorbic acid tolerable for colonoscopy in an early morning visit to a comprehensive medical check-up?
abstract: OBJECTIVE
  To evaluate the effectiveness and tolerability of a split-dose 2 L polyethylene glycol (PEG)/ascorbic acid (AA) regimen for healthy examinees who visited for comprehensive medical check-up in the early morning.
  
  
  METHODS
  From February 2015 to March 2015, examinees of average risk who were scheduled for a colonoscopy in the morning were retrospectively enrolled.
  
  
  RESULTS
  The 189 examinees were divided into split-dose and non-split-dose groups. The adequacy of bowel preparation for the split-dose groupvsthe non-split-dose group was 96.8%vs85.2%, respectively,P< 0.001, and the compliance of the last meal restriction was 74.6%vs58.2%, respectively,P< 0.001. The sleep disturbance (P< 0.001) was more prevalent in the split-dose group, however the willingness to repeat the same preparation method (P= 0.243) was not different in both groups. The split-dose regimen was the most important factor influencing adequate bowel preparation in multivariate analysis (HR = 10.89, 95%CI: 6.53-18.17,P< 0.001).
  
  
  CONCLUSIONS
  A split-dose regimen of 2 L PEG/AA for an early morning colonoscopy was more effective and showed better compliance for diet restriction without any difference in satisfaction and discomfort. Introducing a split-dose regimen of 2 L PEG/AA to morning colonoscopy examinees is effective and tolerable in a comprehensive medical check-up setting.
authors.affiliation: Ji Yeon Seo, Changhyun Lee, Eun Hyo Jin, Joo Hyun Lim, Hae Yeon Kang, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim, Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, South Korea.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Seo
authors.affiliation: Ji Yeon Seo, Changhyun Lee, Eun Hyo Jin, Joo Hyun Lim, Hae Yeon Kang, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim, Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, South Korea.
authors.forename: Changhyun
authors.initials: C
authors.lastname: Lee
authors.affiliation: Ji Yeon Seo, Changhyun Lee, Eun Hyo Jin, Joo Hyun Lim, Hae Yeon Kang, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim, Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, South Korea.
authors.forename: Eun Hyo
authors.initials: EH
authors.lastname: Jin
authors.affiliation: Ji Yeon Seo, Changhyun Lee, Eun Hyo Jin, Joo Hyun Lim, Hae Yeon Kang, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim, Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, South Korea.
authors.forename: Mi Hyun
authors.initials: MH
authors.lastname: Yun
authors.affiliation: Ji Yeon Seo, Changhyun Lee, Eun Hyo Jin, Joo Hyun Lim, Hae Yeon Kang, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim, Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, South Korea.
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Lim
authors.affiliation: Ji Yeon Seo, Changhyun Lee, Eun Hyo Jin, Joo Hyun Lim, Hae Yeon Kang, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim, Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, South Korea.
authors.forename: Hae Yeon
authors.initials: HY
authors.lastname: Kang
authors.affiliation: Ji Yeon Seo, Changhyun Lee, Eun Hyo Jin, Joo Hyun Lim, Hae Yeon Kang, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim, Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, South Korea.
authors.forename: Jong In
authors.initials: JI
authors.lastname: Yang
authors.affiliation: Ji Yeon Seo, Changhyun Lee, Eun Hyo Jin, Joo Hyun Lim, Hae Yeon Kang, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim, Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, South Korea.
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Chung
authors.affiliation: Ji Yeon Seo, Changhyun Lee, Eun Hyo Jin, Joo Hyun Lim, Hae Yeon Kang, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim, Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, South Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Yang
authors.affiliation: Ji Yeon Seo, Changhyun Lee, Eun Hyo Jin, Joo Hyun Lim, Hae Yeon Kang, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim, Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, South Korea.
authors.forename: Joo Sung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D002400:Cathartics / Q000008:administration & dosage* / Q000009:adverse effects; D003113:Colonoscopy / Q000379:methods*; D003191:Comprehensive Health Care; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D017060:Patient Satisfaction; D010808:Physical Examination; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D002400:Cathartics; D011092:Polyethylene Glycols; D001205:Ascorbic Acid
keywords: Compliance; Early morning colonoscopy; Effectiveness; Split-dose regimen; Tolerability