title: An Asymmetric Organocatalysis Approach to the Prenylated Alkaloid Family.
abstract: Michael addition of a proline-derived triketopiperazine (TKP) to β-substituted enones and acrylamides, mediated by a cinchona alkaloid catalyst, delivers products possessing a bicyclo[2.2.2]diazaoctane structure in high yield and enantiomeric ratio (er). Further modification of the amide products toward polycyclic scaffolds resembling members of the prenylated alkaloid family is also demonstrated.
authors.affiliation: School of Chemistry, University of Birmingham , Edgbaston, Birmingham, B15 2TT, U.K.
authors.forename: Matthew
authors.initials: M
authors.lastname: Rees
authors.affiliation: School of Chemistry, University of Birmingham , Edgbaston, Birmingham, B15 2TT, U.K.
authors.forename: Nigel S
authors.identifier: 0000-0001-7483-0742
authors.initials: NS
authors.lastname: Simpkins
authors.affiliation: School of Chemistry, University of Birmingham , Edgbaston, Birmingham, B15 2TT, U.K.
authors.forename: Louise
authors.initials: L
authors.lastname: Male