title: Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies.
abstract: OBJECTIVE
  To describe new technologies (biomarkers and tests) used to assess and monitor the severity and progression of multiple organ dysfunction syndrome in children as discussed as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop (March 26-27, 2015).
  
  
  METHODS
  Literature review, research data, and expert opinion.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Moderated by an experienced expert from the field, investigators developing and assessing new technologies to improve the care and understanding of critical illness presented their research and the relevant literature.
  
  
  RESULTS
  Summary of presentations and discussion supported and supplemented by relevant literature.
  
  
  CONCLUSIONS
  There are many innovative tools and techniques with the potential application for the assessment and monitoring of severity of multiple organ dysfunction syndrome. If the reliability and added value of these candidate technologies can be established, they hold promise to enhance the understanding, monitoring, and perhaps, treatment of multiple organ dysfunction syndrome in children.
authors.affiliation: 1Department of Pediatrics and the Steele Children's Research Center, University of Arizona College of Medicine-Tucson, Tucson, AZ. 2Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH. 3Biomedical Engineering Department, Viterbi School of Engineering, University of Southern California, Los Angeles, CA. 4Department of Pediatrics and Communicable Diseases, C.S. Mott Children's Hospital, and Department of Biomedical Engineering, Michigan Center for Integrated Research in Critical Care, University of Michigan, Ann Arbor, MI. 5Division of Thoracic Surgery and Critical Care Medicine, Department of Surgery, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada. 6Division of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte-Justine Hospital, Université de Montréal, Montréal, QC, Canada.
authors.forename: Katri V
authors.initials: KV
authors.lastname: Typpo
authors.forename: Hector R
authors.initials: HR
authors.lastname: Wong
authors.forename: Stacey D
authors.initials: SD
authors.lastname: Finley
authors.forename: Rodney C
authors.initials: RC
authors.lastname: Daniels
authors.forename: Andrew J E
authors.initials: AJ
authors.lastname: Seely
authors.forename: Jacques
authors.initials: J
authors.lastname: Lacroix
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002648:Child; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness; D018450:Disease Progression; D006801:Humans; D008954:Models, Biological; D008991:Monitoring, Physiologic; D009102:Multiple Organ Failure / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D010372:Pediatrics; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers