title: Post translational modification of Parkin.
abstract: Mutations in the gene encoding for the E3 ubiquitin ligase Parkin are associated to a rare form of familiar autosomal recessive Parkinsonism. Despite decades of research on the Parkin protein, whose structure has been recently solved, little is known about the specific signalling pathways that lead to Parkin activation. Parkin activity spans from mitochondria quality control to tumor suppression and stress protection; it is thus tempting to hypothesize that the broad impact of Parkin on cellular physiology might be the result of different post translational modifications that can be controlled by balanced opposing events. Sequence alignment of Parkin from different species indicates high homology between domains across Parkin orthologs and identifies highly conserved amino acid residues that, if modified, impinge on Parkin functions. In this review, we summarize findings on post translational modifications that have been shown to affect Parkin activity and stability.
  
  
  
  This article was reviewed by Prof. Dr. Konstanze F. Winklhofer and by Prof. Thomas Simmen. Both reviewers have been nominated by Professor Luca Pellegrini.
authors.affiliation: Department of Biology, University of Padova, Via Ugo Bassi 58b, 35131, Padova, Italy.
authors.forename: Joy
authors.initials: J
authors.lastname: Chakraborty
authors.affiliation: Department of Biology, University of Padova, Via Ugo Bassi 58b, 35131, Padova, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Basso
authors.affiliation: Department of Biology, University of Padova, Via Ugo Bassi 58b, 35131, Padova, Italy. elena.ziviani@unipd.it.|Istituto IRCCS San Camillo, Lido di Venezia, Venezia,, Italy. elena.ziviani@unipd.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Ziviani
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D055550:Protein Stability; D016415:Sequence Alignment; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D044767:Ubiquitin-Protein Ligases; C111567:parkin protein
keywords: Parkin; Parkinson’s disease; Phosphorylation; Post translational modifications; Ubiquitination