title: Proteasomes, caught in the act.
abstract: Although energy-dependent protein destruction by the proteasome has been known for over 30 years, how this intricate molecular machine uses ATP to power protein degradation has remained very poorly understood. In a recently published paper, Ding et al. present a snapshot of the proteasome mid-catalysis, yielding new and unexpected insights into the catalytic mechanism of this ATP-powered multisubunit machine.
authors.affiliation: Department of Biomedical Sciences, Florida State University College of Medicine, 1115 W. Call Street, Tallahassee, FL 32306, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Tomko
mesh_terms: D000244:Adenosine Diphosphate; D020285:Cryoelectron Microscopy; D003593:Cytoplasm; D046988:Proteasome Endopeptidase Complex; D059748:Proteolysis
chemical_list: D000244:Adenosine Diphosphate; D046988:Proteasome Endopeptidase Complex