title: [Differences Between Self- and Proxy-Assessment of Health-Related Quality of Life in Patients with Mild Cognitive Impairment and Alzheimer's Disease].
abstract: The self-assessment of health-related quality of life (HrQoL) in patients with Alzheimer's disease (AD) and mild cognitive impairment is commonly higher than the proxy-assessment by caregivers. This study aims at evaluating sociodemographic and clinical factors to explain this difference.
  
  
  
  HrQoL of 241 community-dwelling patients was analysed using the dementia-specific Quality of Life-Alzheimer's Disease questionnaire (QoL-AD). Behavioural and psychological symptoms and functional capacity were evaluated using the Geriatric Depression Scale (GDS), the Neuropsychiatric Inventory (NPI) and the Alzheimer's Disease Cooperative Study-Activities of Daily Living scale (ADCS-ADL).
  
  
  
  The self-assessment of patients' HrQoL was significantly higher than the caregiver-ratings (mean difference: 7.4 ± 5.6, p < 0.001). Considerable influencing factors were the extent of depressive symptoms (GDS), the degree of impairment in functional performance (ADCS-ADL) and the relationship between patients and caregivers.
  
  
  
  Independent variables explained 23 % of the variance in the difference between self- and proxy-assessment of HrQoL. Future studies should include further influencing factors such as caregivers' mental health.
authors.affiliation: Klinik für Neurologie, Philipps-Universität Marburg.|Klinik für Psychiatrie und Psychotherapie, Universitätsmedizin Göttingen.
authors.forename: Philipp
authors.initials: P
authors.lastname: Heßmann
authors.affiliation: Institut für Epidemiologie, Sozialmedizin und Gesundheitssystemforschung, Medizinische Hochschule Hannover.
authors.forename: Maren
authors.initials: M
authors.lastname: Dreier
authors.affiliation: Institut für Epidemiologie, Sozialmedizin und Gesundheitssystemforschung, Medizinische Hochschule Hannover.
authors.forename: Iris
authors.initials: I
authors.lastname: Brandes
authors.affiliation: Klinik für Neurologie, Philipps-Universität Marburg.
authors.forename: Richard
authors.initials: R
authors.lastname: Dodel
authors.affiliation: Abteilung für Allgemeinmedizin, Präventive und Rehabilitative Medizin, Philipps-Universität Marburg.
authors.forename: Erika
authors.initials: E
authors.lastname: Baum
authors.affiliation: Vitos Klinikum für Psychiatrie und Psychotherapie Gießen-Marburg und Justus-Liebig-Universität Gießen.
authors.forename: Matthias J
authors.initials: MJ
authors.lastname: Müller
authors.affiliation: Klinik für Neurologie, Philipps-Universität Marburg.
authors.forename: Monika
authors.initials: M
authors.lastname: Balzer-Geldsetzer
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000523:psychology; D017028:Caregivers; D060825:Cognitive Dysfunction; D005858:Germany; D006801:Humans; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life