title: Therapeutic journey of 2,4-thiazolidinediones as a versatile scaffold: An insight into structure activity relationship.
abstract: Thiazolidinedione is an important heterocyclic ring system, a pharmacophore and a privileged scaffold in medicinal chemistry; is a derivative of thiazolidine ring which came into existence for its role as antihyperglycemic agent and a specific ligand of PPAR's (Peroxisome proliferator activated receptor). Exhaustive research has led to determination of its vast biological profile with wide range of therapeutic applications. This review covers recent pharmacological advancements of thiazolidinedione moiety along with structure activity relationship so as to provide better correlation among different structures and their receptor interactions.
authors.affiliation: Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India.
authors.forename: Mohd Javed
authors.initials: MJ
authors.lastname: Naim
authors.affiliation: Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India.
authors.forename: Md Jahangir
authors.initials: MJ
authors.lastname: Alam
authors.affiliation: Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India.
authors.forename: Shujauddin
authors.initials: S
authors.lastname: Ahmad
authors.affiliation: Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India.
authors.forename: Farah
authors.initials: F
authors.lastname: Nawaz
authors.affiliation: Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India.
authors.forename: Neelima
authors.initials: N
authors.lastname: Shrivastava
authors.affiliation: Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India.
authors.forename: Meeta
authors.initials: M
authors.lastname: Sahu
authors.affiliation: Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India. Electronic address: dr.ozairalam@gmail.com.
authors.forename: Ozair
authors.initials: O
authors.lastname: Alam
mesh_terms: D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D013329:Structure-Activity Relationship; D045162:Thiazolidinediones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D007004:Hypoglycemic Agents; D047492:Peroxisome Proliferator-Activated Receptors; D045162:Thiazolidinediones; C089946:2,4-thiazolidinedione
keywords: Anticancer; Antihyperglycemic; Antimicrobial; PPARγ; Thiazolidinedione