title: Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals.
abstract: Punch sticking is a frequently occurring problem that challenges successful tablet manufacturing. A mechanistic understanding of the punch sticking phenomenon facilitates the design of effective strategies to solve punch sticking problems of a drug. The first step in this effort is to identify process parameters and particle properties that can profoundly affect sticking performance. This work was aimed at elucidating the key material properties and compaction parameters that influence punch sticking by statistically analyzing punch sticking data of 24 chemically diverse compounds obtained using a set of tooling with removable upper punch tip. Partial least square (PLS) analysis of the data revealed that particle surface area and tablet tensile strength are the most significant factors attributed to punch sticking. Die-wall pressure, ejection force, and take-off force also correlate with sticking, but to a lesser extent.
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127 B Weaver-Densford Hall,308 Harvard Street S.E., Minneapolis, MN 55455, United States.
authors.forename: Shubhajit
authors.initials: S
authors.lastname: Paul
authors.affiliation: Pfizer Worldwide Research & Development,Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom.
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Taylor
authors.affiliation: Pfizer Worldwide Research & Development, Groton, CT, 06340, United States.
authors.forename: Brendan
authors.initials: B
authors.lastname: Murphy
authors.affiliation: Pfizer Worldwide Research & Development, Groton, CT, 06340, United States.
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Krzyzaniak
authors.affiliation: Pfizer Worldwide Research & Development,Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom.
authors.forename: Neil
authors.initials: N
authors.lastname: Dawson
authors.affiliation: Pfizer Worldwide Research & Development, Groton, CT, 06340, United States.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Mullarney
authors.affiliation: Pfizer Worldwide Research & Development, Groton, CT, 06340, United States.
authors.forename: Paul
authors.initials: P
authors.lastname: Meenan
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127 B Weaver-Densford Hall,308 Harvard Street S.E., Minneapolis, MN 55455, United States. Electronic address: sunx0053@umn.edu.
authors.forename: Changquan Calvin
authors.initials: CC
authors.lastname: Sun
mesh_terms: D016018:Least-Squares Analysis; D010316:Particle Size; D016062:Porosity; D011208:Powders; D013499:Surface Properties; D013607:Tablets; D013678:Technology, Pharmaceutical; D013718:Tensile Strength
chemical_list: D011208:Powders; D013607:Tablets
keywords: Linear regression; PLS analysis; Powder compaction; Sticking; Surface area; Tensile strength