title: Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL.
abstract: Lipoproteins modulate innate and adaptive immune responses. In the chronic inflammatory disease multiple sclerosis (MS), reports on lipoprotein level alterations are inconsistent and it is unclear whether lipoprotein function is affected. Using nuclear magnetic resonance (NMR) spectroscopy, we analysed the lipoprotein profile of relapsing-remitting (RR) MS patients, progressive MS patients and healthy controls (HC). We observed smaller LDL in RRMS patients compared to healthy controls and to progressive MS patients. Furthermore, low-BMI (BMI ≤ 23 kg/m2) RRMS patients show increased levels of small HDL (sHDL), accompanied by larger, triglyceride (TG)-rich VLDL, and a higher lipoprotein insulin resistance (LP-IR) index. These alterations coincide with a reduced serum capacity to accept cholesterol via ATP-binding cassette (ABC) transporter G1, an impaired ability of HDL3to suppress inflammatory activity of human monocytes, and modifications of HDL3's main protein component ApoA-I. In summary, lipoprotein levels and function are altered in RRMS patients, especially in low-BMI patients, which may contribute to disease progression in these patients.
authors.affiliation: Hasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
authors.forename: Winde
authors.initials: W
authors.lastname: Jorissen
authors.affiliation: Hasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
authors.forename: Elien
authors.initials: E
authors.lastname: Wouters
authors.affiliation: Hasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
authors.forename: Jeroen F
authors.initials: JF
authors.lastname: Bogie
authors.affiliation: Hasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
authors.forename: Tim
authors.initials: T
authors.lastname: Vanmierlo
authors.affiliation: Hasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Noben
authors.affiliation: NIH, Dept. of Laboratory Medicine, Clinical Center, Bethesda, United States.
authors.forename: Denis
authors.initials: D
authors.lastname: Sviridov
authors.affiliation: Hasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
authors.forename: Niels
authors.initials: N
authors.lastname: Hellings
authors.affiliation: Hasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
authors.forename: Veerle
authors.initials: V
authors.lastname: Somers
authors.affiliation: Hasselt University, Faculty of Sciences, Molecular and Physical Plant Physiology, Diepenbeek, Belgium.
authors.forename: Roland
authors.initials: R
authors.lastname: Valcke
authors.affiliation: Revalidation and MS Center, Overpelt, Belgium.
authors.forename: Bart
authors.initials: B
authors.lastname: Vanwijmeersch
authors.affiliation: Hasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
authors.forename: Piet
authors.initials: P
authors.lastname: Stinissen
authors.affiliation: Erasmus MC, Dept. of Vasc. and Met. diseases, Rotterdam, the Netherlands.
authors.forename: Monique T
authors.initials: MT
authors.lastname: Mulder
authors.affiliation: NIH, Dept. of Laboratory Medicine, Clinical Center, Bethesda, United States.
authors.forename: Alan T
authors.initials: AT
authors.lastname: Remaley
authors.affiliation: Hasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
authors.forename: Jerome J A
authors.initials: JJ
authors.lastname: Hendriks
mesh_terms: D000070998:ATP Binding Cassette Transporter, Subfamily G, Member 1 / Q000097:blood* / Q000235:genetics; D056704:Adaptive Immunity; D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood* / Q000235:genetics; D015992:Body Mass Index; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D006801:Humans; D007113:Immunity, Innate; D007333:Insulin Resistance; D008075:Lipoproteins, HDL / Q000097:blood* / Q000145:classification / Q000235:genetics; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology* / Q000473:pathology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D014280:Triglycerides / Q000097:blood
chemical_list: C505693:APOA1 protein, human; D000070998:ATP Binding Cassette Transporter, Subfamily G, Member 1; D016632:Apolipoprotein A-I; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008075:Lipoproteins, HDL; D014280:Triglycerides