title: [Extracorporeal photochemotherapy as prevention of graft rejection, coupled with declining infectious complications rates in urological patients].
abstract: This study presents results of extracorporeal photochemotherapy (EPCT) application in 24 renal allograft recipients (RAR), who suffered chronic kidney disease (CKD) caused by urological diseases. The comparison group treated only with chemical immunosuppression comprised 24 recipients who received transplants from the same donors as intervention group patients. It was found that EPCT reduces not only the number of RAR rejections, but also the incidence of infectious complications. The effectiveness of EFHT was confirmed by clinical, laboratory and immunological data, and by protocol biopsy results. Possible mechanisms of preservation of anti-infectious protection in the setting of chemical immunosuppression when using EPCT are discussed.
authors.affiliation: Department of Transplantation, Nephrology and Surgical Hemocorrection, MRRCI n.a. M.F. Vladimirskiy, Moscow.
authors.forename: V A
authors.initials: VA
authors.lastname: Fedulkina
authors.affiliation: Department of Transplantation, Nephrology and Surgical Hemocorrection, MRRCI n.a. M.F. Vladimirskiy, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Vatazin
authors.affiliation: Department of Transplantation, Nephrology and Surgical Hemocorrection, MRRCI n.a. M.F. Vladimirskiy, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Kil'dyushevskiy
authors.affiliation: Department of Transplantation, Nephrology and Surgical Hemocorrection, MRRCI n.a. M.F. Vladimirskiy, Moscow.
authors.forename: A B
authors.initials: AB
authors.lastname: Zul'karnaev
authors.affiliation: Department of Transplantation, Nephrology and Surgical Hemocorrection, MRRCI n.a. M.F. Vladimirskiy, Moscow.
authors.forename: R O
authors.initials: RO
authors.lastname: Kantariya
mesh_terms: D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D017893:Photopheresis; D014019:Tissue Donors
keywords: acute rejection; extracorporeal photochemotherapy; photopheresis; renal transplantation; urinary tract infection; urology