title: Local targeting NF-κB in the lung tissue of TB-infected mice diminishes the level of pathology.
abstract: Mice of the genetically TB-susceptible strain I/St were infected with ∼100 CFU of Mycobacterium tuberculosis strain H37Rv, and after week 3 post-infection treated by inhalations of the NBD peptide selectively blocking NF-κB activation pathway. This therapy resulted in a pronounced attenuation of lung pathology and down-regulation of the expression of several genes encoding major inflammatory molecules, but did not diminish the level of mycobacterial multiplication in the lungs.
authors.affiliation: Department of Immunology, Central Institute for Tuberculosis, Moscow, Russia.
authors.forename: Galena
authors.initials: G
authors.lastname: Shepelkova
authors.affiliation: Department of Immunology, Central Institute for Tuberculosis, Moscow, Russia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Evstifeev
authors.affiliation: Department of Immunology, Central Institute for Tuberculosis, Moscow, Russia.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Kondratieva
authors.affiliation: Department of Immunology, Central Institute for Tuberculosis, Moscow, Russia.
authors.forename: Irina
authors.initials: I
authors.lastname: Bocharova
authors.affiliation: Department of Immunology, Central Institute for Tuberculosis, Moscow, Russia.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Averbakh
authors.affiliation: Department of Immunology, Central Institute for Tuberculosis, Moscow, Russia; Department of Immunology, School of Biology, Moscow State University, Russia. Electronic address: asapt@aha.ru.
authors.forename: Alexander
authors.initials: A
authors.lastname: Apt
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000472:pathogenicity*; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010446:Peptide Fragments / Q000008:administration & dosage*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D016328:NF-kappa B; D010446:Peptide Fragments
keywords: Lung pathology; NBD peptide; NF-κB; TB inflammation