title: Clinical Evidence of Increase in Hair Growth and Decrease in Hair Loss without Adverse Reactions Promoted by the Commercial Lotion ECOHAIR®.
abstract: OBJECTIVE
  Hair exerts protection, sensory functions, thermoregulation, and sexual attractiveness. Hair loss (alopecia) is caused by several diseases, drug intake, hormone imbalance, stress, and infections (Malassesia furfur). Drugs usually used in alopecia produce irreversible systemic and local side effects. An association of extracts of Coffea arabica and Larrea divaricata (ECOHAIR®) is successfully being commercialized in Argentina for hair growth. The aim of this study was to provide scientific support for the efficacy and innocuousness of ECOHAIR® in patients with noncicatricial alopecia during a 3-month treatment.
  
  
  METHODS
  The efficacy was determined through the assessment of an increase in hair volume, improvement in hair looks, growth of new hair, and a decrease in hair loss by the test of hair count and hair traction. The capacity to decrease the amount of dandruff was also evaluated as well as the adverse local effects caused by the treatment.
  
  
  RESULTS
  ECOHAIR® spray improved the overall hair volume and appearance; it increased its thickness, induced hair growth, and decreased hair loss. Besides, no adverse local reactions were observed upon treatment with the product.
  
  
  CONCLUSIONS
  This study provides scientific support for the clinical use of ECOHAIR® as a treatment to be used in noncicatricial alopecia.
authors.affiliation: Facultad de Farmacia y Bioquímica, Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Buenos Aires, Argentina.
authors.forename: María Rosario
authors.initials: MR
authors.lastname: Alonso
authors.forename: Claudia
authors.initials: C
authors.lastname: Anesini
mesh_terms: D000328:Adult; D000368:Aged; D000505:Alopecia / Q000188:drug therapy*; D040503:Coffea; D005260:Female; D006197:Hair / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D032442:Larrea; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D010936:Plant Extracts