title: Synthesis and Antibacterial Activity of Novel Hydroxy Semicarbazone Derivatives.
abstract: A series of hydroxyl semicarbazone derivatives of substituted diaryl ketones and acetophenones were synthesized and their structures were confirmed by analytical and spectroscopic methods including elemental analysis, infrared and nuclear magnetic resonance spectroscopy. The derivatives were prepared by a condensation reaction betweenN-hydroxy semicarbazide and substituted diaryl ketones or acetophenones leading to the desired hydroxysemicarbazones with excellent purity. The synthesized hydrazones were then evaluated for their inhibitory activity against bacterial strains includingS. aureus,E. Coli,P. aeruginosa,K. pneumoniaandM. luteus. Among the tested derivatives, compounds 2, 6 and 7 exhibited the highest bioactivity. Analysis of the activity data suggests that hydrophilicity is an important factor for the bioactivity of compounds 2 and 6 and also their selectivity over the gram-negative bacteria.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Hariri
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Mahboubi
authors.affiliation: Department of Anestesiology, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Fathi
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Rahmani
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Kamaleddin
authors.initials: K
authors.lastname: Haj Mohammad Ebrahim Tehrani
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Babaeian
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Vida
authors.initials: V
authors.lastname: Mashayekhi
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Iran.
authors.forename: Farzad
authors.initials: F
authors.lastname: Kobarfard
keywords: Antibacterial; Broth microdilution assay; Hydrophilicity; Ketones; N-hydroxy semicarbazone