title: Association of the FADS gene cluster with coronary artery disease and plasma lipid concentrations in the northern Chinese Han population.
abstract: We investigated the association of single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene cluster with coronary artery disease (CAD) in a case-control study and evaluated the possible influence of genetic variation on total cholesterol (TC) and triglyceride concentrations in the controls. In total, 497 CAD patients and 495 unrelated controls were genotyped for eight SNPs in the FADS gene cluster, and the blood lipid levels of subjects were measured. Three genetic models, including codominant, dominant and recessive, were used to analyze the genotypic relationship with CAD and plasma lipid levels. Single locus genotypic analysis revealed that rs1000778 in FADS3 under a recessive model (AA vs. GG-GA) was significantly associated with CAD adjusted for risk factors. The rs1000778 minor allele AA was associated with a lower risk of CAD (OR =0.37, 95% CI: 0.15-0.89, P=0.025). In the control group, there were significant differences in TC concentrations under a recessive genetic model for rs174575 (C/G) in FADS2 and for rs174450 (A/C) and rs7115739 (G/T) in FADS3 (P=0.053, 0.016 and 0.018, respectively). The rs1000778-G variant in FADS3 may contribute to the susceptibility of CAD, but the result needs to be further confirmed because of small sample size in our study. Genetic variations in FADS2 and FADS3 influence TC concentration in the northern Chinese Han population.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Chang Chun 130021, China.
authors.forename: Yixia
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Chang Chun 130021, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Chang Chun 130021, China.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Chang Chun 130021, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021,China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ye
authors.affiliation: Department of Cardiology, First Hospital, Jilin University, Changchun 130031, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
authors.affiliation: Department of Cardiology, First Hospital, Jilin University, Changchun 130031, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Chang Chun 130021, China. Electronic address: xielin@jlu.edu.cn.
authors.forename: Lin
authors.initials: L
authors.lastname: Xie
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D002784:Cholesterol / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D000090943:Delta-5 Fatty Acid Desaturase; D044943:Fatty Acid Desaturases / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood*
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; D014280:Triglycerides; D002784:Cholesterol; D044943:Fatty Acid Desaturases; C533241:FADS2 protein, human; C545859:FADS3 protein, human