title: Correlation of enhanced oxidative stress with altered thyroid profile: Probable role in spontaneous abortion.
abstract: BACKGROUND
  Spontaneous abortion or miscarriage is defined as the loss of a clinically recognized pregnancy that occurs before 20 weeks of gestational age. Changes in thyroid function can impact greatly on reproductive function before, during, and after conception. Oxidative stress affects both implantation and early embryo development by modifying the key of transcription. Malondialdehyde (MDA) is a major breakdown product of split off from lipid peroxidation. Superoxide dismutase (SOD) is responsible for detoxification of superoxide anion and required for normal health and reproduction.
  
  
  OBJECTIVE
  The aim of this study was to define the involvement of thyroid hormones, MDA and SOD levels and to establish MDA levels as an index of lipid peroxidation in women with spontaneous abortion by comparing the results with healthy pregnant females as controls.
  
  
  METHODS
  A cross-sectional case-control study was designed with two groups of women with 30 each in healthy pregnancy and with spontaneous abortion.
  
  
  RESULTS
  Demographic characteristics such as maternal age, paternal age, gestational age, body mass index, waist-hip ratio as well as biochemical parameters such as blood pressure, hemoglobin (Hb), sugar levels were found to be similar in both the participating groups. Characteristics like gravida and parity were found to be higher in the study group and differ significantly from control group. Spontaneous abortion before 24 weeks of gestational age was found to be associated with significant increase in mean serum thyroid stimulating hormone (TSH) (P= 0.0115) and MDA (P= 0.0001) levels and a significant decrease in mean serum T3 (P= 0.0003) and SOD (P= 0.0005) levels. The linear (Pearson) correlation analysis demonstrated a significant positive correlation of TSH with MDA and negative correlation with SOD in women with spontaneous abortion.
  
  
  CONCLUSIONS
  The study demonstrates that altered thyroid profile, increased lipid peroxidation in terms of increased MDA levels and decreased SOD levels might be involved in the termination of otherwise wanted pregnancy.
authors.affiliation: Centre for Interdisciplinary Biomedical Research, Adesh University, Bathinda, Punjab, India.
authors.forename: Kaur
authors.initials: K
authors.lastname: Ramandeep
authors.affiliation: Department of Biochemistry, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Gupta
authors.initials: G
authors.lastname: Kapil
authors.affiliation: Department of Obstetrics and Gynecology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Kaur
authors.initials: K
authors.lastname: Harkiran
keywords: Malondialdehyde; oxidative stress; spontaneous abortion; superoxide dismutase; thyroid hormones