title: Effects of Afobazole on Postnatal Development of Rat Offspring.
abstract: Physical development, development of sensory and motor reflexes, behavioral and mnestic patterns were studied infantile and juvenile rat pups born by female rats receiving Afobazole during pregnancy. Physical development and development of sensory and motor reflexes in rats were completed without pathologies by the age of 2 months. During the infantile period, the rat pups demonstrated reduced body weight gain, delayed eye opening and pupillary response formation, decreased muscle force, and suppressed motor behavior. During the juvenile period, body weight gain and development of motor behavior were intensified. Females demonstrated later vagina opening and poorer mnestic responses. In males, the terms of sexual maturation were unchanged and processes of learning and memory retrieval were not impaired.
authors.affiliation: Research Institute of Pharmacology, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia. lb.bugaeva@rambler.ru.
authors.forename: L I
authors.initials: LI
authors.lastname: Bugaeva
authors.affiliation: Research Institute of Pharmacology, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: T D
authors.initials: TD
authors.lastname: Denisova
authors.affiliation: Research Institute of Pharmacology, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.affiliation: Research Institute of Pharmacology, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Morozova
authors.affiliation: Research Institute of Pharmacology, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Kharlamov
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001562:Benzimidazoles / Q000009:adverse effects*; D005260:Female; D018811:Maternal Exposure / Q000009:adverse effects*; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D009025:Morpholines / Q000009:adverse effects*; D009043:Motor Activity / Q000187:drug effects; D053580:Muscle Strength / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects / Q000254:growth & development; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology* / Q000503:physiopathology; D051381:Rats; D012025:Reflex, Pupillary / Q000187:drug effects; D012741:Sexual Maturation / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines
keywords: Afobazole; ontogenesis; physical development; rat offspring