title: CRH Receptors in Human Reproduction.
abstract: Corticotropin releasing hormone (CRH), the main peptide-mediator of stress, has been found in the female reproductive system.
  
  
  
  Herein, the role of CRH receptors in the female reproductive system is presented.
  
  
  
  It is clear that CRH receptors are involved in the regulation of the hypothalamic-pituitaryovarian axis, while locally are associated with decidualization, embryonic implantation, early fetal development and triggering of parturition.
  
  
  
  Abnormal CRH signaling may contribute to obstetrical pathophysiology, such as preeclampsia, abnormal placenta invasion, endometrial growth retardation and preterm delivery.
authors.affiliation: Department of Obstetrics and Gynecology, Medical School, University of Crete, Heraklion. Greece.
authors.forename: Antonis
authors.initials: A
authors.lastname: Makrigiannakis
authors.affiliation: Department of Obstetrics and Gynecology, Medical School, University of Ioannina, Ioannina. Greece.
authors.forename: Thomas
authors.initials: T
authors.lastname: Vrekoussis
authors.affiliation: 1st Department of Pediatrics and Choremion Laboratory, Medical School, University of Athens, Athens. Greece.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Zoumakis
authors.affiliation: Department of Obstetrics and Gynecology, Medical School, University of Ioannina, Ioannina. Greece.
authors.forename: Iordanis
authors.initials: I
authors.lastname: Navrozoglou
authors.affiliation: 2nd Department of Obstetrics and Gynecology, Medical School, University of Athens, Athens. Greece.
authors.forename: Sophia N
authors.initials: SN
authors.lastname: Kalantaridou
mesh_terms: D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D010064:Embryo Implantation; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D036801:Parturition / Q000378:metabolism; D011247:Pregnancy; D018019:Receptors, Corticotropin-Releasing Hormone / Q000378:metabolism*; D012098:Reproduction
chemical_list: D018019:Receptors, Corticotropin-Releasing Hormone; D003346:Corticotropin-Releasing Hormone
keywords: CRH receptors; fetal immunotolerance; implantation; ovary; parturition; receptivity