title: The Role of Body Weight on Bone in Anorexia Nervosa: A HR-pQCT Study.
abstract: Anorexia nervosa (AN) is associated with decreased bone mineral density and increased risk of fracture. The aim of this study was to assess bone geometry, volumetric bone mineral density (vBMD), trabecular microarchitecture and estimated failure load in weight-bearing vs. non-weight-bearing bones in AN. We included twenty-five females with AN, and twenty-five female controls matched on age and height. Bone geometry, vBMD and trabecular microarchitecture were assessed using high-resolution peripheral quantitative computed tomography of the distal radius and tibia. At both sites, cortical perimeter and total bone area were similar in patients and controls. Total vBMD was lower in the AN group in the tibia (p < 0.0005) but not in the radius. In the tibia, cortical thickness was approximately 25% lower (p < 0.0005) in the AN group, whereas there was no significant difference in the radius. In terms of trabecular microarchitecture, all indices [bone volume/tissue volume (BV/TV); trabecular thickness (Tb.Th.), trabecular number (Tb.N) and trabecular spacing (Tb.Sp.)] were impaired in AN in the tibia (p values range < 0.01-0.0001). In the radius, BV/TV and Tb.N were lower (p < 0.05 and p < 0.001, respectively); Tb.Sp. was higher (p < 0.001), whereas Tb.Th. did not differ, compared to controls. Estimated failure load was lower in patients in both the radius and the tibia (p < 0.0005 and p < 0.0001, respectively), most pronounced in the tibia. In conclusion, the impairment of cortical thickness and estimated failure load were significantly more pronounced in the weight-bearing tibia, compared to the non-weight-bearing radius, implying a direct effect of low body weight on bone loss in AN.
authors.affiliation: Centre for Eating Disorders, Department of Endocrinology, Odense University Hospital & Psychiatry of Region Southern Denmark, University of Southern Denmark, Odense, Denmark. Jacob.froelich@rsyd.dk.|Department of Endocrinology, Odense University Hospital, Odense, Denmark. Jacob.froelich@rsyd.dk.|Centre of Eating Disorders and Department of Endocrinology, Odense University Hospital, Kloevervaenget 10, 6th floor, 5000, Odense C, Denmark. Jacob.froelich@rsyd.dk.
authors.forename: Jacob
authors.identifier: 0000-0001-8156-2424
authors.initials: J
authors.lastname: Frølich
authors.affiliation: Department of Endocrinology, Odense University Hospital, Odense, Denmark.
authors.forename: Stinus
authors.initials: S
authors.lastname: Hansen
authors.affiliation: Centre for Eating Disorders, Department of Endocrinology, Odense University Hospital & Psychiatry of Region Southern Denmark, University of Southern Denmark, Odense, Denmark.|Department of Endocrinology, Odense University Hospital, Odense, Denmark.
authors.forename: Laura Al-Dakhiel
authors.initials: LA
authors.lastname: Winkler
authors.affiliation: Center for Spine Surgery and Research, Region of Southern Denmark, Middelfart, Denmark.
authors.forename: Andreas K
authors.initials: AK
authors.lastname: Andresen
authors.affiliation: Department of Endocrinology, Odense University Hospital, Odense, Denmark.
authors.forename: Anne Pernille
authors.initials: AP
authors.lastname: Hermann
authors.affiliation: Centre for Eating Disorders, Department of Endocrinology, Odense University Hospital & Psychiatry of Region Southern Denmark, University of Southern Denmark, Odense, Denmark.|Department of Endocrinology, Odense University Hospital, Odense, Denmark.
authors.forename: René K
authors.initials: RK
authors.lastname: Støving
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000856:Anorexia Nervosa / Q000473:pathology*; D001835:Body Weight; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: Anorexia nervosa; Bone geometry; Bone microarchitecture; High-resolution peripheral quantitative computed tomography; Mechanical loading