title: Association between C1q gene polymorphisms and autoimmune thyroid diseases.
abstract: OBJECTIVE
  In the present study, we aimed to assess the associations of C1q gene polymorphisms with autoimmune thyroid diseases (AITD) susceptibility.
  
  
  METHODS
  A set of 1,003 AITD patients (661 with Graves' disease and 342 with Hashimoto's thyroiditis) and 880 ethnically- and geographically-matched controls from Chinese Han population were included. Five common single nucleotide polymorphisms (SNPs) (rs294185, rs292001, rs682658, rs665691 and rs294179) in C1q gene locus were genotyped. Frequencies of genotypes and alleles were compared between patients and controls, and haplotype analysis was also performed.
  
  
  RESULTS
  There was no statistically significant difference between AITD patients and controls in the frequencies of alleles of rs294185 (P = 0.41), rs292001 (P = 0.71), rs682658 (P = 0.68), rs665691 (P = 0.68) and rs294179 (P = 0.69). There was also no statistically significant difference between AITD patients and controls in the frequencies of genotypes of rs294185 (P = 0.72), rs292001 (P = 0.89), rs682658 (P = 0.83), rs665691 (P = 0.90) and rs294179 (P = 0.43). Stratified analyses showed that none of those five SNPs in C1q gene were associated with Graves' disease or Hashimoto's thyroiditis (all P values > 0.05). Haplotype analysis revealed that there were no obvious genetic associations of C1q gene polymorphisms with AITD susceptibility.
  
  
  CONCLUSIONS
  We, for the first time, identified the associations between C1q gene SNPs and AITD, and our findings suggested that five common SNPs in C1q gene were not associated with AITD susceptibility in Chinese Han population.
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: Qiuming
authors.initials: Q
authors.lastname: Yao
authors.affiliation: Department of Nephrology, Xi'an Central Hospital, Xi'an, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: An
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Qin
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Song
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: Ni
authors.initials: N
authors.lastname: Yan
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: Danfeng
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: Liangfeng
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: Jin-An
authors.initials: JA
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D015922:Complement C1q / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006111:Graves Disease / Q000235:genetics*; D050031:Hashimoto Disease / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D015922:Complement C1q