title: Transoral robotic surgery for management of cervical unknown primary squamous cell carcinoma: Updates on efficacy, surgical technique and margin status.
abstract: Management of cervical unknown primary squamous cell carcinoma (CUP) has evolved with the introduction of transoral robotic surgery (TORS).
  
  
  
  1. To describe the efficacy of TORS lingual and palatine tonsillectomy in identifying the primary site of malignancy. 2. To explore how the extent of surgery affects diagnostic yield. 3. To report margin status of TORS resections.
  
  
  
  A retrospective, single-center cohort study utilizing a prospectively collected database of CUP patients in a high-volume tertiary referral center. Patient underwent operative laryngoscopy plus TORS as clinically indicated.
  
  
  
  Primary end point was successful identification of the primary. The extent of surgery and margin status were also examined.
  
  
  
  From 2010-2016, 64 patients with CUP were treated. The primary tumor was found in 51 patients (80%). Fourteen patients (22%) were identified with operative laryngoscopy alone. Fifty patients underwent TORS lingual tonsillectomy ± palatine tonsillectomy with 37 primary tumors identified (74%). The primary was located in the lingual tonsil in 32 patients (86%) and palatine tonsil in 5 patients (10%, p<0.001). Negative margins were achieved in 19 patients (51%). The deep margin was the most commonly positive margin (47%, p=0.049).
  
  
  
  Operative laryngoscopy with TORS is efficacious, localizing the primary in 80% of patients. If a margin was positive, it was most commonly the deep margin. This study provides valuable information that can help standardize surgical technique, further increasing the diagnostic yield and decreasing the negative margin rate of TORS for CUP.
authors.affiliation: UPMC Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Mathew
authors.initials: M
authors.lastname: Geltzeiler
authors.affiliation: UPMC Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Doerfler
authors.affiliation: UPMC Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Meghan
authors.initials: M
authors.lastname: Turner
authors.affiliation: UPMC Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: William Greer
authors.initials: WG
authors.lastname: Albergotti
authors.affiliation: UPMC Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Kubik
authors.affiliation: UPMC Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Seungwon
authors.initials: S
authors.lastname: Kim
authors.affiliation: UPMC Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Ferris
authors.affiliation: UPMC Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address: duvuriu@upmc.edu.
authors.forename: Umamaheswar
authors.initials: U
authors.lastname: Duvvuri
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D005260:Female; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009333:Neck; D065287:Robotic Surgical Procedures; D000077195:Squamous Cell Carcinoma of Head and Neck; D016896:Treatment Outcome
keywords: Carcinoma of unknown primary; Head and neck cancer; Head and neck pathology; Head and neck radiotherapy; Human papilloma virus; Oropharyngeal cancer; Radiation oncology; Robotic surgery; Squamous cell carcinoma; Squamous cell carcinoma of unknown primary; Transoral robotic surgery; Unknown primary squamous cell carcinoma