title: Clinical Perspectives of Genetic Analyses on Dyslipidemia and Coronary Artery Disease.
abstract: We have learned that low-density lipoprotein (LDL) cholesterol is the cause of atherosclerosis from various aspects, including a single case with familial hypercholesterolemia, other cases with different types of Mendelian dyslipidemias, large-scale randomized controlled trials using LDL cholesterol lowering therapies, and Mendelian randomization studies using common as well as rare variants associated with LDL cholesterol levels. There is no doubt that determinations of genotypes in lipid-associated genes have contributed not only to the genetic diagnosis for Mendelian dyslipidemias but also to the discoveries of novel therapeutic targets. Furthermore, recent studies have shown that such genetic information could provide useful clues for the risk prediction as well as risk stratification in general and in particular population. We provide the current understanding of genetic analyses relating to plasma lipids and coronary artery disease.
authors.affiliation: Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine.
authors.forename: Hayato
authors.initials: H
authors.lastname: Tada
authors.affiliation: Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine.
authors.forename: Masa-Aki
authors.initials: MA
authors.lastname: Kawashiri
authors.affiliation: Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamagishi
mesh_terms: D003324:Coronary Artery Disease / Q000235:genetics* / Q000473:pathology*; D050171:Dyslipidemias / Q000235:genetics* / Q000473:pathology*; D006801:Humans
keywords: Coronary artery disease; Dyslipidemia; Familial hypercholesterolemia; PCSK9