title: TNF-Alpha in Peripheral Neuropathy Patients with Impaired Glucose Regulation.
abstract: Impaired glucose regulation (IGR) is the prestate of diabetes; about 1/3 of IGR patients will develop to diabetes finally. In this study, we investigated the serum tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels in peripheral neuropathy impaired patients with impaired glucose regulation (IGR). A total of 70 IGR patients received the conventional nerve conduction test, including 30 patients with peripheral neuropathy (PN) and 40 patients without peripheral neuropathy (NPN). The other 40 healthy individuals were recruited as controls. The serum TNF-αand IL-6 in IGR patients were higher than in control group, and serum TNF-αand IL-6 levels in IGR-PN group were higher than in IGR-NPN group (27.7 ± 17.8 versus 13.1 ± 6.7 pg/mL and 18.1 ± 17.7 versus 6.4 ± 3.7 pg/mL, resp., bothp< 0.05). Multifactors logistic regression analysis showed that TNF-α(OR = 0.893;p= 0.009) was an independent factor affecting whether IGR could combine with peripheral neuropathy. TNF-αand IL-6 could aggregate peripheral neuropathy in impaired glucose regulation patients; TNF-αmight be independent risk factor for peripheral neuropathy in glucose regulation impaired patients.
authors.affiliation: The Third Central Clinical College of Tianjin Medical University, Tianjin, China; Department of Neurology, Tianjin Third Central Hospital, Tianjin, China; Tianjin Key Laboratory of Artificial Cell, Tianjin, China.
authors.forename: Xia
authors.identifier: 0000-0002-6848-8626
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Neurology, Tianjin Third Central Hospital, Tianjin, China; Tianjin Key Laboratory of Artificial Cell, Tianjin, China.
authors.forename: Ju
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Tianjin Third Central Hospital, Tianjin, China; Tianjin Key Laboratory of Artificial Cell, Tianjin, China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: Department of Neurology, Tianjin Third Central Hospital, Tianjin, China; Tianjin Key Laboratory of Artificial Cell, Tianjin, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurology, Tianjin Third Central Hospital, Tianjin, China; Tianjin Key Laboratory of Artificial Cell, Tianjin, China.
authors.forename: Zhecheng
authors.identifier: 0000-0002-0066-3897
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000097:blood* / Q000503:physiopathology; D005260:Female; D018149:Glucose Intolerance / Q000097:blood* / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D010523:Peripheral Nervous System Diseases / Q000097:blood* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha