title: Enhancement of visual chiral sensing via an anion-binding approach: Novel ionic liquids as the chiral selectors.
abstract: Novel task-specific ionic liquids derived from (S)-phenyl amino acid were prepared as a chiral sensor for the first time. It was found that the ionic liquids exhibited different chiral visual responses to the enantiomers. When (S)-tryptophan was treated with the sensor and Cu(II) in water, the clear solution would change to a sapphire suspension. Differently, another enantiomer could not produce the precipitate. Furthermore, the enantiomers could generate different colors in DMSO under the same conditions. The substantial difference contributes to the easy discrimination with visual determination. Four racemates were successfully tested with this strategy. The precipitation was isolated in the range of 90-94% yields after complete formation of the coordinative bonds, which could be as a simple way for enantioseparation. The responsive mechanism of the sensor was studied by NMR spectroscopy, FTIR and SEM. UV-vis spectrophotometer was used to monitor the colorimetric signal of the racemate with different e.e.
  
  
  METHODS
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Datong
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Yin
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Cai
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou, 310027, China. Electronic address: panyuanjiang@zju.edu.cn.
authors.forename: Yuanjiang
authors.initials: Y
authors.lastname: Pan
keywords: Chiral sensing; Color changes; Ionic liquids; Precipitate formation