title: Lifestyle for Brain Health (LIBRA): a new model for dementia prevention.
abstract: OBJECTIVE
  Modifiable risk factors for dementia were recently identified and compiled in a systematic review. The 'Lifestyle for Brain Health' (LIBRA) score, reflecting someone's potential for dementia prevention, was studied in a large longitudinal population-based sample with respect to predicting cognitive change over an observation period of up to 16 years.
  
  
  METHODS
  Lifestyle for Brain Health was calculated at baseline for 949 participants aged 50-81 years from the Maastricht Ageing Study. The predictive value of LIBRA for incident dementia and cognitive impairment was examined by using Cox proportional hazard models and by testing its relation with cognitive decline.
  
  
  RESULTS
  Lifestyle for Brain Health predicted future risk of dementia, as well as risk of cognitive impairment. A one-point increase in LIBRA score related to 19% higher risk for dementia and 9% higher risk for cognitive impairment. LIBRA predicted rate of decline in processing speed, but not memory or executive functioning.
  
  
  CONCLUSIONS
  Lifestyle for Brain Health (LIBRA) may help in identifying and monitoring risk status in dementia-prevention programmes, by targeting modifiable, lifestyle-related risk factors. Copyright © 2017 John Wiley & Sons, Ltd.
authors.affiliation: School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
authors.forename: Olga J G
authors.initials: OJG
authors.lastname: Schiepers
authors.affiliation: School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Köhler
authors.affiliation: School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
authors.forename: Kay
authors.initials: K
authors.lastname: Deckers
authors.affiliation: School of Nursing and Human Sciences, Dublin City University, Dublin, Ireland.
authors.forename: Kate
authors.initials: K
authors.lastname: Irving
authors.affiliation: General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: O'Donnell
authors.affiliation: Department of General Practice, Maastricht University, Maastricht, The Netherlands.
authors.forename: Marjan
authors.initials: M
authors.lastname: van den Akker
authors.affiliation: School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
authors.forename: Frans R J
authors.initials: FRJ
authors.lastname: Verhey
authors.affiliation: School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
authors.forename: Stephanie J B
authors.initials: SJB
authors.lastname: Vos
authors.affiliation: School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
authors.forename: Marjolein E
authors.initials: ME
authors.lastname: de Vugt
authors.affiliation: School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
authors.forename: Martin P J
authors.initials: MPJ
authors.lastname: van Boxtel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain; D003072:Cognition Disorders / Q000453:epidemiology / Q000517:prevention & control*; D060825:Cognitive Dysfunction / Q000517:prevention & control; D015897:Comorbidity; D003704:Dementia / Q000453:epidemiology / Q000517:prevention & control*; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D015994:Incidence; D008019:Life Style; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012307:Risk Factors
keywords: ageing; cognitive function; dementia; lifestyle; prevention