title: MAGUKs: multifaceted synaptic organizers.
abstract: The PSD-95 family of proteins, known as MAGUKs, have long been recognized to be central building blocks of the PSD. They are categorized as scaffolding proteins, which link surface-expressed receptors to the intracellular signaling molecules. Although the four members of the PSD-95 family (PSD-95, PSD-93, SAP102, and SAP97) have many shared roles in regulating synaptic function, recent studies have begun to delineate specific binding partners and roles in plasticity. In the current review, we will highlight the conserved and unique roles of these proteins.
authors.affiliation: Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, United States.
authors.forename: Sehoon
authors.initials: S
authors.lastname: Won
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, United States.
authors.forename: Jon M
authors.initials: JM
authors.lastname: Levy
authors.affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, United States; Department of Physiology, University of California, San Francisco, CA 94158, United States.
authors.forename: Roger A
authors.initials: RA
authors.lastname: Nicoll
authors.affiliation: Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address: rochek@ninds.nih.gov.
authors.forename: Katherine W
authors.initials: KW
authors.lastname: Roche
mesh_terms: D000076122:Disks Large Homolog 4 Protein / Q000378:metabolism; D051528:Guanylate Kinases / Q000378:metabolism*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
chemical_list: D000076122:Disks Large Homolog 4 Protein; D009419:Nerve Tissue Proteins; D051528:Guanylate Kinases