title: Prognostic Evaluation of Neutrophil/Lymphocyte Ratio in Patients with Mycosis Fungoides.
abstract: BACKGROUND
  The role of inflammation has been established in cancer biology and the neutrophil to lymphocyte ratio postulated as a marker of systemic inflammatory response. The prognostic significance of neutrophil to lymphocyte ratio has never been explored in patients with mycosis fungoides.
  
  
  METHODS
  Data from 119 mycosis fungoides (MF) patients, diagnosed between 1998 and 2015 at a single centre, were evaluated retrospectively. The prognostic influence of the neutrophil to lymphocyte ratio and other clinico-pathological factors including age, lactate dehydrogenase, stage of disease, beta-2-microglobulin levels, and total IgE levels were evaluated.
  
  
  RESULTS
  The mean value of absolute neutrophil count and absolute lymphocyte count (ANC/ALC) ratio was 2.07±1.17 in the patient group, whereas it was 1.76±0.53 in the control group (P<0.05). An ANC/ALC value of 2.85 corresponded to the maximum combined sensitivity and specificity on the ROC curve. ANC/ALC ratios of 2.85 or higher at diagnosis were positively correlated with elevated Beta-2-microglobulin (P=0.026), advanced disease stage, and disease progression (P=0.026, r=0.204) (P=0 .006, r=0.251) (P=0 .018, r=0.216).
  
  
  CONCLUSIONS
  In the present study, we showed that a high ANC/ALC ratio at diagnosis of MF represents a simple, poor prognostic factor for identifying high-risk patients with MF.
authors.affiliation: Department of Dermatoveneorology, Bezmialem Vakif University, Bezmialem Vakif University Hospital, Istanbul, Turkey fpelinozgen@hotmail.com.
authors.forename: Fatma Pelin
authors.initials: FP
authors.lastname: Cengiz
authors.affiliation: Department of Dermatoveneorology, Bezmialem Vakif University, Bezmialem Vakif University Hospital, Istanbul, Turkey.
authors.forename: Nazan
authors.initials: N
authors.lastname: Emiroglu
authors.affiliation: Department of Dermatoveneorology, Bezmialem Vakif University, Bezmialem Vakif University Hospital, Istanbul, Turkey.
authors.forename: Dilek Biyik
authors.initials: DB
authors.lastname: Ozkaya
authors.affiliation: Department of Dermatoveneorology, Bezmialem Vakif University, Bezmialem Vakif University Hospital, Istanbul, Turkey.
authors.forename: Anil Gulsel
authors.initials: AG
authors.lastname: Bahali
authors.affiliation: Department of Dermatoveneorology, Bezmialem Vakif University, Bezmialem Vakif University Hospital, Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Su
authors.affiliation: Department of Dermatoveneorology, Bezmialem Vakif University, Bezmialem Vakif University Hospital, Istanbul, Turkey.
authors.forename: Nahide
authors.initials: N
authors.lastname: Onsun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000276:immunology* / Q000473:pathology; D009504:Neutrophils / Q000276:immunology*; D011379:Prognosis; D055815:Young Adult
keywords: Lymphocyte; Mycosis Fungoides; Neutrophil; Prognosis; Ratio