title: The role of IL-1 gene polymorphisms (IL1A, IL1B, and IL1RN) as a risk factor in unsuccessful implants retaining overdentures.
abstract: OBJECTIVE
  Implant-supported overdentures are an alternative predictable rehabilitation method that has a high impact on improving the patient's quality of life. However, some biological complications may interfere with the maintenance and survival of these overdenture implants. The goal of this article was to assess the factors that affect peri-implant success, through a hypothetical prediction model for biological complications of implant overdentures.
  
  
  METHODS
  A retrospective observational, prevalence study was conducted in 58 edentulous Caucasian patients rehabilitated with implant overdentures. A total of 229 implants were included in the study. Anamnestic, clinical, and implant-related parameters were collected and recorded in a single database. "Patient" was chosen as the unit of analysis, and a complete screening protocol was established. The data analytical study included assessing the odds ratio, concerning the presence or absence of a particular risk factor, by using binary logistic regression modeling. Probability values (p values) inferior to 0.05 were considered as representing statistically significant evidence.
  
  
  RESULTS
  The performed prediction model included the following variables: mean probing depth, metal exposure, IL1B_allele2, maxillary edentulousness, and Fusobacterium nucleatum. The F. nucleatum showed significant association with the outcome. Introducing a negative coefficient appeared to prevent complications or even boost the biological defense when associated with other factors.
  
  
  CONCLUSIONS
  The prediction model developed in this study could serve as a basis for further improved models that would assist clinicians in the daily diagnosis and treatment planning practice of oral rehabilitation with implant overdentures.
authors.affiliation: Department of Removable Prosthesis, Faculty of Dental Medicine of the University of Porto, Portugal. Electronic address: mfernandes@fmd.up.pt.
authors.forename: Margarida
authors.initials: M
authors.lastname: Sampaio Fernandes
authors.affiliation: Department of Orofacial Genetics, Faculty of Dental Medicine of the University of Porto, Portugal. Electronic address: pvaz@fmd.up.pt.
authors.forename: Paula
authors.initials: P
authors.lastname: Vaz
authors.affiliation: Department of Production and Systems Engineering-Algoritmi Centre, University of Minho, Braga, Portugal. Electronic address: acb@dps.uminho.pt.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Braga
authors.affiliation: Department of Fixed Prosthesis, Faculty of Dental Medicine of the University of Porto, Portugal. Electronic address: jfernandes@fmd.up.pt.
authors.forename: João Carlos
authors.initials: JC
authors.lastname: Sampaio Fernandes
authors.affiliation: Department of Removable Prosthesis, Faculty of Dental Medicine of the University of Porto, Portugal. Electronic address: mhsilva@fmd.up.pt.
authors.forename: Maria Helena
authors.initials: MH
authors.lastname: Figueiral
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015921:Dental Implants / Q000009:adverse effects; D019094:Dental Prosthesis, Implant-Supported / Q000009:adverse effects; D019232:Dental Restoration Failure; D003828:Denture, Overlay / Q000009:adverse effects; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011110:Polymorphism, Genetic; D011541:Pseudallescheria; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D015921:Dental Implants; D007375:Interleukin-1
keywords: Dental implants; Gene polymorphism; Overdentures; Risk factor; Unsuccessful