title: Glomerular Diseases and Renal Transplantation: Pathogenic Pathways and Evolution of Therapeutic Interventions.
abstract: Glomerular diseases and renal transplantation are the main fields of nephrology in which the immune system plays a prevalent role. Glomerular diseases have traditionally been attributed to auto-immune conditions, whereas allograft rejection has been considered an allo-immune response. However, common immunopathologic mechanisms that include Toll-like receptors, complement and B-cell activation, as well as genetic and infectious factors appear to be involved in the pathogenesis of both entities. Novel therapeutic regimens directed against specific targets of the immune system show promising results in glomerulopathies as well as in renal transplantation.
authors.affiliation: Nephrology Department and Renal Transplantation Unit, Laiko Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Marinaki
authors.affiliation: Nephrology Department and Renal Transplantation Unit, Laiko Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Skalioti
authors.affiliation: Nephrology Department and Renal Transplantation Unit, Laiko Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: laikneph@laiko.gr.
authors.forename: J
authors.initials: J
authors.lastname: Boletis
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology* / Q000601:surgery; D001402:B-Lymphocytes / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000502:physiology; D007674:Kidney Diseases / Q000276:immunology / Q000601:surgery*; D007678:Kidney Glomerulus / Q000276:immunology*; D016030:Kidney Transplantation; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D051193:Toll-Like Receptors; D003165:Complement System Proteins