title: Mangiferin antagonizes TNF-α-mediated inflammatory reaction and protects against dermatitis in a mice model.
abstract: This study aimed to investigate whether mangiferin played a protective role in a well-established dermatitis mouse model and tumor necrosis factor alpha (TNF-α)-induced RAW264.7 macrophages. Contact dermatitis is an inflammatory skin disease in the clinic, while its underlying mechanism still remains to be elucidated. Mangiferin, 1,3,6,7-tetrahydroxyxanthone-C2-β-d-glucoside (C-glucosyl xanthone), a natural antioxidant that was reported to inhibit inflammatory reactions, has been recently proved to be a potential therapy for inflammation. As a result, the oxazolone-induced dermatitis mice models were established to explore whether mangiferin has an anti-inflammatory role in vivo. The phosphate-buffered saline treatment groups showed emblematic skin inflammation, whereas the administration of mangiferin obviously inhibited dermatitis in the mice models. Furthermore, exogenous mangiferin alleviated the inflammatory reaction in TNF-α-induced macrophages by suppressing the production of inflammation- and oxidative stress-associated molecules. Also, mangiferin treatment repressed the activation of nuclear factor-kappaB signaling pathway. To sum up, mangiferin could provide a new target for the therapy and prevention of skin inflammation.
authors.affiliation: Department of Orthopaedics, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: School of Medcine, Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Wenhan
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Gynaecology and Obstetrics, Jinan Central Hospital, Shandong University, Jinan, Shandong, 250012, PR China.
authors.forename: Xihai
authors.initials: X
authors.lastname: Wu
authors.affiliation: School of Medcine, Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Ma
authors.affiliation: School of Medcine, Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Ruize
authors.initials: R
authors.lastname: Qu
authors.affiliation: School of Medcine, Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Chen
authors.affiliation: School of Medcine, Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Chenghao
authors.initials: C
authors.lastname: Liu
authors.affiliation: School of Medcine, Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Yaoge
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Medcine, Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Xiaokai
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Medcine, Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Yan
authors.affiliation: School of Medcine, Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Medcine, Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Jingrui
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of Pathology, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, PR China. Electronic address: miraculously2008@163.com.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Li
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003877:Dermatitis, Contact / Q000188:drug therapy*; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010081:Oxazolone; D000067996:RAW 264.7 Cells; D015398:Signal Transduction / Q000187:drug effects; D012867:Skin / Q000187:drug effects* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D044004:Xanthones / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D014409:Tumor Necrosis Factor-alpha; D044004:Xanthones; D010081:Oxazolone; C013592:mangiferin
keywords: Dermatitis; Inflammation; Mangiferin; NF-κB signaling pathway; RAW264.7 macrophage; TNF-α