title: Differential Regional Distribution of Juxtacortical White Matter Signal Abnormalities in Aging and Alzheimer's Disease.
abstract: White matter signal abnormalities (WMSA) (also known as 'hyperintensities') on MRI are commonly seen in normal aging and increases have been noted in Alzheimer's disease (AD), but whether there is a spatial specificity to these increases is unknown.
  
  
  
  To discern whether or not there is a spatial pattern of WMSA in the brains of individuals with AD that differs from those who exhibit cognitively healthy aging.
  
  
  
  Structural MRI data from the Alzheimer's Disease Neuroimaging Initiative public database were used to quantify WMSA in 35 regions of interest (ROIs). Regional measures were compared between cognitively healthy older controls (OC; n = 107) and individuals with a clinical diagnosis of AD (n = 127). Regional WMSA volume was also assessed in individuals with mild cognitive impairment (MCI; n = 74) who were 6, 12, and 24 months away from AD conversion.
  
  
  
  WMSA volume was significantly greater in AD compared to OC in 24 out of 35 ROIs after controlling for age, and nine were significantly higher after normalizing for total WMSA. Regions with greater WMSA volume in AD included rostral frontal, inferior temporal, and inferior parietal WM. In MCI, frontal and temporal regions demonstrated significantly greater WMSA volume with decreasing time-to-AD-conversion.
  
  
  
  Individuals with AD have greater regional volume of WMSA compared to OC regardless of age or total WMSA volume. Accumulation of regional WMSA is linked to time to AD conversion in individuals with MCI. These findings indicate WMSA is an important pathological component of AD development.
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.|Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.|Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Emily R
authors.initials: ER
authors.lastname: Lindemer
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.|Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Douglas N
authors.initials: DN
authors.lastname: Greve
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.|Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.|Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.|Computer Science and Artificial Intelligence Laboratory (CSAIL), Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
authors.forename: Bruce
authors.initials: B
authors.lastname: Fischl
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.|Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Jean C
authors.initials: JC
authors.lastname: Augustinack
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.|Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.|Neuroimaging Research for Veterans (NeRVe) Center, VA Boston Healthcare System, Boston, MA, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Salat
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D000073656:Healthy Aging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D066127:White Matter / Q000000981:diagnostic imaging*
keywords: Aging; Alzheimer’s disease; cerebrovascular; hyperintensities; magnetic resonance imaging; mild cognitive impairment; white matter