title: Brain Perfusion Before and After Surgical Treatment of Moyamoya Disease.
abstract: Moyamoya disease is characterized by bilateral progressive terminal internal carotid arteries steno-occlusion. In this patient, the disease affected middle cerebral arteries and was disclosed after a left frontal cerebral infarction. Brain HMPAO perfusion scintigraphy with acetazolamide challenge, obtained before surgical treatment, demonstrates an extended bilateral frontal hypoperfusion with a vascular steal phenomenon. The same examination obtained after surgical treatment demonstrates a frank improvement in basal brain vascularization, with nearly complete correction of vascular steal phenomenon. HMPAO brain scintigraphy is a very useful tool in the assessment of moyamoya disease severity before surgery and for the evaluation of treatment efficiency.
authors.affiliation: From the *Department of Nuclear Medicine, University Hospital Jean Minjoz, Besançon; †University of Bourgogne Franche-Comté; ‡EA 4662-Nanomedicine Lab, Imagery and Therapeutics; and §Department of Neurosurgery, University Hospital Jean Minjoz, Besançon, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Drouet
authors.forename: Olivier
authors.initials: O
authors.lastname: Morel
authors.forename: Laurent
authors.initials: L
authors.lastname: Thines
authors.forename: Clémence
authors.initials: C
authors.lastname: Porot
authors.forename: Hatem
authors.initials: H
authors.lastname: Boulahdour
mesh_terms: D000086:Acetazolamide; D001921:Brain / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000209:etiology*; D009072:Moyamoya Disease / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D011877:Radionuclide Imaging
chemical_list: D000086:Acetazolamide