title: The usefulness of 18F-fluorocholine PET/CT in the detection of recurrence of central nervous system primary neoplasms.
abstract: OBJECTIVE
  To study the usefulness of18F-fluorocholine (FCH) in detecting the recurrence of primary brain tumours.
  
  
  METHODS
  A prospective study was conducted on brain PET/CT with FCH for compassionate use in 21 patients with suspected recurrence of a primary brain tumour. The distribution by pathology was: three grade ii astrocytomas, three grade iii astrocytomas, one grade ii oligodendroglioma, three grade iii oligodendrogliomas, one grade iii oligoastrocytoma, four glioblastoma multiform, one gliomatosis cerebri, and five meningiomas. Studies in which there was a visually significant uptake in the brain parenchyma were classified as positive.
  
  
  RESULTS
  A total of 17 patients were classified as positive, with the results being confirmed by histology (10 cases) or clinical follow-up and imaging, with no false positives or negatives. The mean SUVmax for positive patients was 8.02 and 0.94 for the negative ones, which was significantly different (P=.003) CONCLUSION: PET/CT with FCH shows encouraging results in the evaluation of patients with suspected recurrence of primary brain neoplasms.
authors.affiliation: Servicio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Barcelona, España. Electronic address: amontegr7@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Montes
authors.affiliation: Servicio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: A
authors.initials: A
authors.lastname: Fernández
authors.affiliation: Servicio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: V
authors.initials: V
authors.lastname: Camacho
authors.affiliation: Servicio de Neurocirugía, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: C
authors.initials: C
authors.lastname: de Quintana
authors.affiliation: Servicio de Oncología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: O
authors.initials: O
authors.lastname: Gallego
authors.affiliation: Servicio de Oncología Radioterápica, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Craven-Bartle
authors.affiliation: Servicio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: D
authors.initials: D
authors.lastname: López
authors.affiliation: Servicio de Neurocirugía, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Molet
authors.affiliation: Servicio de Radiología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: B
authors.initials: B
authors.lastname: Gómez-Ansón
authors.affiliation: Servicio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: I
authors.initials: I
authors.lastname: Carrió
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D002454:Cell Differentiation; D002794:Choline / Q000031:analogs & derivatives*; D005260:Female; D005462:Fluorine Radioisotopes; D005910:Glioma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging*; D008579:Meningioma / Q000000981:diagnostic imaging*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D009485:Neuroradiography; D000072078:Positron Emission Tomography Computed Tomography; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D014018:Tissue Distribution
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; C514960:fluorocholine; D002794:Choline
keywords: (18)F-fluorocholine; (18)F-fluorocolina; Brain PET/CT; Brain tumour; Neuro-oncology; Neurooncología; PET/TC cerebral; Recidiva; Recurrence; Tumor cerebral