title: Reset Osmostat: The Result of Chronic Desmopressin Abuse?
abstract: A reset osmostat as a cause of hyponatremia can be found in a variety of clinical settings, including pulmonary and neurologic diseases, as well as in physiologic circumstances such as pregnancy. This teaching case describes a 72-year-old white man with a long-standing history of self-medicating with desmopressin acetate (DDAVP) who presented with profound hyponatremia. On discontinuation of DDAVP treatment, he was found to have a reset osmostat. The mild hyponatremia persisted on follow-up. We theorize that the reset osmostat may have developed secondary to long-standing DDAVP use.
authors.affiliation: Section of Nephrology, Division of Nephrology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Andreoli
authors.affiliation: Section of Nephrology, Division of Nephrology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL. Electronic address: william_whittier@rush.edu.
authors.forename: William L
authors.initials: WL
authors.lastname: Whittier
mesh_terms: D000368:Aged; D050034:Antidiuretic Agents / Q000009:adverse effects*; D001281:Atrial Fibrillation; D003894:Deamino Arginine Vasopressin / Q000009:adverse effects*; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D007031:Hypothalamus; D008297:Male; D009994:Osmolar Concentration; D011141:Polyuria / Q000188:drug therapy*; D012651:Self Medication; D016482:Urinalysis
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin
keywords: Reset osmostat; desmopressin acetate (DDAVP); hyponatremia; osmolality; osmolality homeostasis; serum sodium; vasopressin