title: Hippocampal Damage and Atrophy Secondary to Status Epilepticus in a Patient with Schizophrenia.
abstract: A 59-year-old man was admitted with respiratory tract infection, compromised conscience and generalized tonic-clonic seizures. His medical history included schizophrenia diagnosis, for which he had been being treated since he was 27 years old. EEG disclosed non-convulsive status epilepticus. A magnetic resonance image (MRI) acquired 3 days later showed increased left hippocampal volume with hyperintensity on T2-weighted and FLAIR sequences. After being treated with antibiotics and antiepileptic medications, the patient's condition improved. A follow-up MRI showed reduction of the left hippocampus. The relationship between epilepsy and schizophrenia is not yet clear. This case illustrates this interaction. Hippocampal atrophy may have been caused by environmental aggression in the present patient with schizophrenia, perhaps in association with a predisposing genotype.
authors.affiliation: Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP) , Botucatu , Brazil.
authors.forename: Elaine Keiko
authors.initials: EK
authors.lastname: Fujisao
authors.affiliation: Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP) , Botucatu , Brazil.
authors.forename: Nathalia Raquel
authors.initials: NR
authors.lastname: Cristaldo
authors.affiliation: Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP) , Botucatu , Brazil.
authors.forename: Aline Marques
authors.initials: AM
authors.lastname: da Silva Braga
authors.affiliation: Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP) , Botucatu , Brazil.
authors.forename: Paulina Rodrigues
authors.initials: PR
authors.lastname: Cunha
authors.affiliation: Departamento de Doenças Tropicais e Diagnósticos por Imagem, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP) , Botucatu , Brazil.
authors.forename: Seizo
authors.initials: S
authors.lastname: Yamashita
authors.affiliation: Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP) , Botucatu , Brazil.
authors.forename: Luiz Eduardo
authors.initials: LE
authors.lastname: Betting
keywords: EEG; hippocampal sclerosis; neuroimaging; schizophrenia; temporal lobe epilepsy