title: Binding of11C-Pittsburgh compound-B correlated with white matter injury in hypertensive small vessel disease.
abstract: OBJECTIVE
  11C-Pittsburgh compound-B (11C-PIB) positron emission tomography (PET) is used to visualize and quantify amyloid deposition in the brain cortex in pathological conditions such as Alzheimer's disease (AD). Intense11C-PIB retention is also observed in the white matter (WM) of both healthy individuals and AD patients. However, the clinical implications of this retention in brain WM have not been clarified. We investigated the relationship between the extent of white matter lesions (WMLs) and the binding potential of11C-PIB (BPND) in the WM in patients with hypertensive small vessel disease. We further examined the relationship between the extent of WMLs and BPNDin WML and in normal-appearing white matter (NAWM).
  
  
  METHODS
  Twenty-one hypertensive vasculopathy patients, without AD and major cerebral arterial stenosis and/or occlusion, were enrolled (9 women, 68 ± 7 years). Regions of WML and NAWM were extracted using magnetization-prepared rapid gradient-echo and fluid-attenuated inversion recovery of magnetic resonance images. Volumes of interest (VOIs) were set in the cortex-subcortex, basal ganglia, and centrum semiovale (CS). BPNDin the cortex-subcortex, basal ganglia, CS, WML, and NAWM were estimated on11C-PIB PET using Logan graphical analysis with cerebellar regions as references. The relationships between WML volume and BPNDin each region were examined by linear regression analysis.
  
  
  RESULTS
  BPNDwas higher in the CS and basal ganglia than in the cortex-subcortex regions. WML volume had a significant inverse correlation with BPNDin the CS (Slope = -0.0042, R2= 0.44, P < 0.01). For intra WM comparison, BPNDin NAWM was significantly higher than that in WML. In addition, although there were no correlations between WML volume and BPNDin WML, WML volume was significantly correlated inversely with BPNDin NAWM (Slope = -0.0017, R2= 0.26, P = 0.02).
  
  
  CONCLUSIONS
  11C-PIB could be a marker of not only cortical amyloid-β deposition but also WM injury accompanying the development of WMLs in hypertensive small vessel disease.
authors.affiliation: Department of Cerebrovascular medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hashimoto
authors.affiliation: Department of Cerebrovascular medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan. cyokota@ncvc.go.jp.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Yokota
authors.affiliation: Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Koshino
authors.affiliation: Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Temma
authors.affiliation: Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Yamazaki
authors.affiliation: Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iguchi
authors.affiliation: Department of Cerebrovascular medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Shimomura
authors.affiliation: Department of Cerebrovascular medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Uehara
authors.affiliation: Department of Cerebrovascular medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Funatsu
authors.affiliation: Department of Cerebrovascular medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
authors.forename: Tenyu
authors.initials: T
authors.lastname: Hino
authors.affiliation: Department of Cerebrovascular medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Minematsu
authors.affiliation: Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Iida
authors.affiliation: Department of Cerebrovascular medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Toyoda
mesh_terms: D000368:Aged; D000814:Aniline Compounds; D052160:Benzothiazoles; D001921:Brain / Q000378:metabolism; D001927:Brain Diseases / Q000000981:diagnostic imaging*; D001931:Brain Mapping / Q000379:methods; D002250:Carbon Radioisotopes / Q000737:chemistry; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010104:Oxygen Radioisotopes / Q000737:chemistry; D049268:Positron-Emission Tomography; D013844:Thiazoles; D066127:White Matter / Q000000981:diagnostic imaging* / Q000293:injuries*
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D052160:Benzothiazoles; D002250:Carbon Radioisotopes; D010104:Oxygen Radioisotopes; D013844:Thiazoles
keywords: 11C-Pittsburgh compound-B; Binding potential; Positron emission tomography; Small vessel disease; White matter lesion