title: Cannabidiol: State of the art and new challenges for therapeutic applications.
abstract: Over the past years, several lines of evidence support a therapeutic potential of Cannabis derivatives and in particular phytocannabinoids. Δ9-THC and cannabidiol (CBD) are the most abundant phytocannabinoids in Cannabis plants and therapeutic application for both compounds have been suggested. However, CBD is recently emerging as a therapeutic agent in numerous pathological conditions since devoid of the psychoactive side effects exhibited instead by Δ9-THC. In this review, we highlight the pharmacological activities of CBD, its cannabinoid receptor-dependent and -independent action, its biological effects focusing on immunomodulation, angiogenetic properties, and modulation of neuronal and cardiovascular function. Furthermore, the therapeutic potential of cannabidiol is also highlighted, in particular in nuerological diseases and cancer.
authors.affiliation: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy. Electronic address: spisanti@unisa.it.
authors.forename: Simona
authors.initials: S
authors.lastname: Pisanti
authors.affiliation: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Malfitano
authors.affiliation: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Ciaglia
authors.affiliation: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Lamberti
authors.affiliation: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Ranieri
authors.affiliation: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy.
authors.forename: Gaia
authors.initials: G
authors.lastname: Cuomo
authors.affiliation: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Abate
authors.affiliation: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Faggiana
authors.affiliation: Department of Pharmacy, University of Salerno, Italy.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Proto
authors.affiliation: Department of Pharmacy, University of Salerno, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Fiore
authors.affiliation: IEOS CNR Naples, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Laezza
authors.affiliation: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy; Corporea, Fondazione Idis-Città della Scienza, Naples, Italy. Electronic address: mbifulco@unisa.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bifulco
mesh_terms: D000818:Animals; D002185:Cannabidiol / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009422:Nervous System Diseases / Q000188:drug therapy
chemical_list: D002185:Cannabidiol
keywords: Cancer; Cannabidiol; Cannabis; Endocannabinoid system; Neurological diseases