title: Clinical study of transcatheter arterial chemoembolization combined with microwave ablation in the treatment of advanced hepatocellular carcinoma.
abstract: OBJECTIVE
  To evaluate the safety and efficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous microwave ablation (MWA) in the treatment of advanced hepatocellular carcinoma (HCC).
  
  
  METHODS
  Three thousand cases of advanced HCC patients were randomly divided into two groups: 1500 cases in the treatment group were treated with TACE combined with MWA and 1500 cases in the control group were treated with TACE.
  
  
  RESULTS
  The effective rate of the treatment group and control group was 71.4% and 42.8%, respectively, and the difference between the two groups was statistically significant (P < 0.05). During the follow-up period at 6, 12, 18, and 24 months postoperatively, the survival rates of the treatment group were 88.1%, 73.8%, 52.3%, and 33.3%, and the survival rates of the control group were 76.2%, 57.1%, 30.9%, and 9.5%, respectively. There was no significant difference in postoperative complications between the two groups.
  
  
  CONCLUSIONS
  It is safe and effective to use TACE combined with MWA in the treatment of advanced HCC, and the effect of combined treatment is better than that of TACE alone.
authors.affiliation: Department of Interventional Therapy and Vascular Surgery, Fourth Clinical Medical College, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Interventional Therapy and Vascular Surgery, Fourth Clinical Medical College, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Wenling
authors.initials: W
authors.lastname: Man
authors.affiliation: Department of Interventional Therapy and Vascular Surgery, Fourth Clinical Medical College, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Huanqing
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Interventional Therapy and Vascular Surgery, Fourth Clinical Medical College, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Po
authors.initials: P
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D016022:Case-Control Studies; D017115:Catheter Ablation / Q000379:methods; D016461:Chemoembolization, Therapeutic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged; D009367:Neoplasm Staging; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome