title: Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm.
abstract: BACKGROUND
  Burns are common event and associated with a high incidence of death, disability, and high costs. Centella asiatica (L.) is a medicinal herb, commonly growing in humid areas in several tropical countries that improve wound healing. On the basis of previous studies, we compared the efficacy of Centiderm versus silver sulfadiazine (SSD) in partial thickness burning patients.
  
  
  METHODS
  Study population comprised burn victims referred to Velayat Burning Hospital at Rasht, Iran. The intervention group received Centiderm and control group SSD cream. Burn wounds were treated once daily at home. All of the wounds were evaluated till complete healing occurred and at the admission, days 3, 7, 14 objective signs; visual acuity score (VAS) and subjective signs were recorded. Re-epithelialization time and complete healing days were recorded. We used random fixed block for randomization. The randomization sequence was created using the computer. Patients and burning specialist physician were blinded.
  
  
  RESULTS
  Seventy-five patients randomized into 2 groups; (40 patients: Centiderm group; 35 patients: SSD group). The mean age of them was 30.67 ± 9.91 years and 19 of them were male (31.7%). Thirty patients in Centiderm and 30 patients in SSD group were analyzed. All of objective and subjective signs and mean of re-epithelialization and complete healing were significantly better in Centiderm group rather than SSD group (P < 0.05). There was no infection in Centiderm group.
  
  
  CONCLUSIONS
  We showed that use of Centiderm ointment not only improved the objective and subjective signs in less than 3 days, but also the re-epithelialization and complete healing rather than SSD without any infection in the subjects.
authors.affiliation: Medicinal Plants Research Center of Student Basij, Guilan University of Medical Sciences, Rasht Cardiology Department & Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad Pharmacognosy Department and Research and Development Center of Plants and Medicinal Chemistry Fellowship of Burn Surgery, Velayat Hospital Social Medicine Department Dermatology Department, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Amin
authors.initials: A
authors.lastname: Saeidinia
authors.forename: Faeze
authors.initials: F
authors.lastname: Keihanian
authors.forename: Ardalan Pasdaran
authors.initials: AP
authors.lastname: Lashkari
authors.forename: Hossein Ghavvami
authors.initials: HG
authors.lastname: Lahiji
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Mobayyen
authors.forename: Abtin
authors.initials: A
authors.lastname: Heidarzade
authors.forename: Javad
authors.initials: J
authors.lastname: Golchai
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000494:pharmacology / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy*; D028041:Centella; D005260:Female; D006801:Humans; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts; D062326:Re-Epithelialization / Q000187:drug effects*; D012837:Silver Sulfadiazine / Q000494:pharmacology / Q000627:therapeutic use*; D014315:Triterpenes / Q000494:pharmacology / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; C526146:Centella asiatica extract; D010936:Plant Extracts; D014315:Triterpenes; D012837:Silver Sulfadiazine