title: Construction of Supramolecular Nanoassembly for Responsive Bacterial Elimination and Effective Bacterial Detection.
abstract: There is an urgent need for developing novel strategies for bacterial detection and inhibition. Herein, a multifunctional nanomaterial based on mesoporous silica nanoparticles (MSNs) is designed, loaded with amoxicillin (AMO), and surface-coated with 1,2-ethanediamine (EDA)-modified polyglycerol methacrylate (PGEDA), cucurbit[7]uril (CB[7]), and tetraphenylethylene carboxylate derivatives (TPE-(COOH)4) by the layer-by-layer (LbL) self-assembly technique. When bacteria contacts with this nanoassembly, the binding of anionic bacterial surface toward the cationic PGEDA layer of this material can reduce or break the interactions between PGEDA layer and TPE-(COOH)4layer, leading to attenuated TPE-(COOH)4emission due to the weakening of aggregation-induced emission (AIE) effect. Furthermore, upon adding adamantaneamine (AD), the more stable AD⊂CB[7] complex forms and PGEDA is liberated through competitive replacement, thus leading to the release of AMO and resulting in much higher antibacterial ability of this nanomaterial. This newly designed nanomaterial possesses dual functions of controllable antibacterial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, and bacterial detection ability in aqueous media, suggesting that the design of this multifunctional antibacterial material will provide a simple, effective, and rapid way to control the activity of antimicrobial and open up an alternative new avenue for bacterial detection and elimination.
authors.affiliation: School of Chemistry and Chemical Engineering, School of Material Science and Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology , No. 391, West Binshui Road, Tianjin 300384, China.
authors.forename: Qiaoying
authors.initials: Q
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, School of Material Science and Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology , No. 391, West Binshui Road, Tianjin 300384, China.
authors.forename: Yuanhao
authors.initials: Y
authors.lastname: Wu
authors.affiliation: School of Chemistry and Chemical Engineering, School of Material Science and Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology , No. 391, West Binshui Road, Tianjin 300384, China.
authors.forename: Hongguang
authors.initials: H
authors.lastname: Lu
authors.affiliation: School of Chemistry and Chemical Engineering, School of Material Science and Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology , No. 391, West Binshui Road, Tianjin 300384, China.
authors.forename: Xinshi
authors.initials: X
authors.lastname: Wu
authors.affiliation: School of Chemistry and Chemical Engineering, School of Material Science and Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology , No. 391, West Binshui Road, Tianjin 300384, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Chen
authors.affiliation: International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), College of Chemistry, Jilin University , 2699 Qianjin Street, Changchun 130012, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Song
authors.affiliation: International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), College of Chemistry, Jilin University , 2699 Qianjin Street, Changchun 130012, China.
authors.forename: Ying-Wei
authors.initials: YW
authors.lastname: Yang
authors.affiliation: School of Chemistry and Chemical Engineering, School of Material Science and Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology , No. 391, West Binshui Road, Tianjin 300384, China.
authors.forename: Hui
authors.identifier: http://orcid.org/0000-0002-5009-9999
authors.initials: H
authors.lastname: Gao
mesh_terms: D000658:Amoxicillin; D000900:Anti-Bacterial Agents; D001419:Bacteria; D049329:Nanostructures; D012822:Silicon Dioxide
chemical_list: D000900:Anti-Bacterial Agents; D012822:Silicon Dioxide; D000658:Amoxicillin
keywords: aggregation-induced emission; antibacterial materials; bacterial detection; controllable antibacterial activity; supramolecular nanoassembly