title: Two new secolignans with in vitro anti-inflammatory activities from Urtica fissa rhizomes.
abstract: Two new secolignans, urticin A (1) and urticin B (2), were isolated from the ethanol extract of Urtica fissa rhizomes. Their structures were elucidated on the basis of extensive spectroscopic evidence (UV, IR, HR-ESI-MS, and NMR). Urticin A and urticin B possessed in vitro anti-inflammatory activities, which significantly inhibited the TNF-α and NO release induced by LPS in RAW 264.7 cells.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Xiaoru
authors.initials: X
authors.lastname: Feng
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. mywang@sjtu.edu.cn.
authors.forename: Mengyue
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Cheng
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. xbli@sjtu.edu.cn.|Enthomedicine Research Center, Yunnan Dali Research Academy of Shanghai Jiao Tong University, Dali, 671000, China. xbli@sjtu.edu.cn.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D000067996:RAW 264.7 Cells; D027343:Rhizome / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D027003:Urticaceae / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D017705:Lignans; D008070:Lipopolysaccharides; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; C000625108:uriticin A; C000625110:uriticin B; D009569:Nitric Oxide
keywords: Anti-inflammatory; Secolignan; Urtica fissa; Urticaceae