title: Frequency-selective alteration in the resting-state corticostriatal-thalamo-cortical circuit correlates with symptoms severity in first-episode drug-naive patients with schizophrenia.
abstract: Schizophrenia is a prototypical disorder of brain connectivity with altered neural activity in regions extending throughout the brain. Regions, including the subcortex and cortex, present activity mainly within a specific frequency band in resting-state. Whether these altered resting-state functional connections also present frequency specificity is unknown. In the present study, empirical mode decomposition, which is a pure data-driven method suitable for nonlinear and nonstationary signals, was used to decompose blood-oxygen-level-dependent (BOLD) signals into different intrinsic frequency bands. Our study included 42 first-episode drug-naive patients with schizophrenia and 38 controls. Significant aberration in functional connectivity was observed only at a higher frequency range (the peak spectral density power was 0.06Hz). In this frequency band, patients with schizophrenia showed significantly increased functional connections between the bilateral cuneus and right supplementary motor area, reduced connections within the basal ganglia, and reduced connections between the dorsal striatum and left supplementary motor area. The dysfunction of the frontal gyrus significantly correlated with the dysfunction of the basal ganglia. Notably, these altered connections were significantly correlated with symptom severity. Our results demonstrate that frequency-selective altered corticostriatal-thalamo-cortical circuits in patients with schizophrenia are associated with symptoms severity.
authors.affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Shaoqiang
authors.initials: S
authors.lastname: Han
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.
authors.forename: X
authors.initials: X
authors.lastname: Zong
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.
authors.forename: M
authors.initials: M
authors.lastname: Hu
authors.affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Long
authors.affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China; The China National Clinical Research Center for Mental Health Disorders, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China; National Technology Institute of Psychiatry, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, 139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China. Electronic address: chenhf@uestc.edu.cn.
authors.forename: Huafu
authors.initials: H
authors.lastname: Chen
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging* / Q000502:physiology; D010100:Oxygen / Q000097:blood; D012146:Rest; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000473:pathology; D013788:Thalamus / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Drug-naive; First-episode; Frequency-selective; Resting state; Schizophrenia