title: Signaling Networks in Epithelial Tube Formation.
abstract: Epithelial tubes are crucial to the function of organ systems including the excretory, gastrointestinal, cardiovascular, and pulmonary. Studies in the last two decades using in vitro organotypic systems and a variety of animal models have substantiated a large number of the morphogenetic mechanisms required to form epithelial tubes in development and regeneration. Many of these mechanisms modulate the differentiation and proliferation events necessary for generating the cell movements and changes in cell shape to delineate the wide variety of epithelial tube sizes, lengths, and conformations. For instance, when coupled with oriented cell division, proliferation itself plays a role in changes in tube shape and their directed expansion. Most of these processes are regulated in response to signaling inputs from adjacent cells or soluble factors from the environment. Despite the great deal of recent investigation in this direction, the knowledge we have about the signaling pathways associated with all epithelial tubulogenesis in development and regeneration is still very limited.
authors.affiliation: Department of Development and Regeneration, Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid 28049, Spain.
authors.forename: Ilenia
authors.initials: I
authors.lastname: Bernascone
authors.affiliation: Department of Development and Regeneration, Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid 28049, Spain.
authors.forename: Mariam
authors.initials: M
authors.lastname: Hachimi
authors.affiliation: Department of Development and Regeneration, Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid 28049, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Martin-Belmonte
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D016764:Cell Polarity; D049109:Cell Proliferation; D004285:Dogs; D004330:Drosophila; D004847:Epithelial Cells / Q000166:cytology; D004848:Epithelium / Q000196:embryology / Q000378:metabolism*; D006801:Humans; D021621:Imaging, Three-Dimensional; D051379:Mice; D018345:Mice, Knockout; D008938:Mitosis; D009024:Morphogenesis; D054259:Neural Tube / Q000378:metabolism; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism; D014981:Xenopus; D015027:Zebrafish
chemical_list: D051153:Wnt Proteins