title: [Contemporary aspects of using sildenafil].
abstract: Sildenafil has been thoroughly studied in 74 registered double-blind, placebo-controlled clinical trials assessing the efficacy and safety of the drug in a total of more than 16 000 men with erectile dysfunction (ED). However, practicing urologists have some questions regarding administering the drug in patients with multiple comorbidities. In this review, on a par with the now "classic" research, we outline the latest updates of meta-analyzes and comparative studies relating to the use of sildenafil in different groups of patients. We also discuss the problem of self-discontinuation of sildenafil therapy and the possible risks of using counterfeit phosphodiesterase type 5 inhibitors (PDE-5i).
authors.affiliation: Department of Andrology and Human Reproduction, N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology branch of NMRRC of Minzdrav of Russia, Moscow.
authors.forename: E A
authors.initials: EA
authors.lastname: Efremov
authors.affiliation: Department of Andrology and Human Reproduction, N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology branch of NMRRC of Minzdrav of Russia, Moscow.
authors.forename: E V
authors.initials: EV
authors.lastname: Kasatonova
authors.affiliation: Department of Andrology and Human Reproduction, N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology branch of NMRRC of Minzdrav of Russia, Moscow.
authors.forename: Ya I
authors.initials: YI
authors.lastname: Melnik
authors.affiliation: Department of Andrology and Human Reproduction, N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology branch of NMRRC of Minzdrav of Russia, Moscow.
authors.forename: V V
authors.initials: VV
authors.lastname: Simakov
mesh_terms: D058110:Counterfeit Drugs / Q000627:therapeutic use; D006801:Humans; D008297:Male; D055118:Medication Adherence; D015201:Meta-Analysis as Topic; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use*; D000068677:Sildenafil Citrate / Q000627:therapeutic use*
chemical_list: D058110:Counterfeit Drugs; D058986:Phosphodiesterase 5 Inhibitors; D000068677:Sildenafil Citrate
keywords: cardiovascular disease; chronic kidney disease; counterfeit medicines; diabetes mellitus; erectile dysfunction; melanoma; nerve-sparing radical prostatectomy; prostate cancer; sildenafil