title: Triticale Bran Alkylresorcinols Enhance Resistance to Oxidative Stress in Mice Fed a High-Fat Diet.
abstract: Triticale (×TriticosecaleWhitm.) is a cereal grain with high levels of alkyresorcinols (AR) concentrated in the bran. These phenolic lipids have been shown to reduce or inhibit triglyceride accumulation and protect against oxidation; however, their biological effects have yet to be evaluatedin vivo. The purpose of this study was to determine the effects of ARs extracted from triticale bran (TB) added to a high-fat diet on the development of obesity and oxidative stress. CF-1 mice were fed a standard low-fat (LF) diet, a 60% high-fat diet (HF) and HF diets containing either 0.5% AR extract (HF-AR), 10% TB (HF-TB), or 0.5% vitamin E (HF-VE). Energy intake, weight gain, glucose tolerance, fasting blood glucose (FBG) levels, and body composition were determined. Oxygen radical absorbance capacity (ORAC), superoxide dismutase (SOD) activity, and glutathione (GSH) assays were performed on mice liver and heart tissues. The findings suggest that ARs may serve as a preventative measure against risks of oxidative damage associated with high-fat diets and obesity through their application as functional foods and neutraceuticals. Future studies aim to identify thein vivomechanisms of action of ARs and the individual homologs involved in their favorable biological effects.
authors.affiliation: Food Science & Nutrition Program, Department of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada. Rania_agil@carleton.ca.
authors.forename: Rania
authors.initials: R
authors.lastname: Agil
authors.affiliation: Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada. zack.patterson@gmail.com.
authors.forename: Zachary R
authors.initials: ZR
authors.lastname: Patterson
authors.affiliation: Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada. harry.m@gmail.com.
authors.forename: Harry
authors.initials: H
authors.lastname: Mackay
authors.affiliation: Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada. Alfonso.AbizaidBucio@carleton.ca.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Abizaid
authors.affiliation: Food Science & Nutrition Program, Department of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada. farah_hosseinian@carleton.ca.|Institute of Biochemistry, Carleton University, Ottawa, ON K1S 5B6, Canada. farah_hosseinian@carleton.ca.
authors.forename: Farah
authors.initials: F
authors.lastname: Hosseinian
keywords: Triticosecale; alkylresorcinols; antioxidant activity; body composition; glucose tolerance; magnetic resonance imaging (MRI); obesity; oxidative stress; triticale bran