title: Vaccine nanoparticles for protection against HIV infection.
abstract: The development of a successful vaccine against HIV is a major global challenge. Antiretroviral therapy is the standard treatment against HIV-1 infection. However, only 46% of the eligible people received the therapy in 2015. Furthermore, suboptimal adherence poses additional obstacles. Therefore, there is an urgent need for an HIV-1 vaccine. The most promising clinical trial to date is Phase III RV144, which for the first time demonstrated the feasibility of vaccine-mediated immune protection against HIV-1. Nevertheless, its 31% efficacy and limited durability underscore major hurdles. Here, we discuss recent progress in HIV-1 vaccine development with a special emphasis on nanovaccines, which are at the forefront of efforts to develop a successful HIV-1 vaccine.
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.|Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Marisa E
authors.initials: ME
authors.lastname: Aikins
authors.affiliation: Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Bazzill
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.|Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: James J
authors.initials: JJ
authors.lastname: Moon
mesh_terms: D016915:AIDS Vaccines / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D015658:HIV Infections / Q000517:prevention & control* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D016915:AIDS Vaccines
keywords: HIV; broadly neutralizing antibody; liposome; nanoparticle; vaccine