title: The use of nanoscaffolds and dendrimers in tissue engineering.
abstract: To avoid tissue rejection during organ transplantation, research has focused on the use of tissue engineering to regenerate required tissues or organs for patients. The biomedical applications of hyperbranched, multivalent, structurally uniform, biocompatible dendrimers in tissue engineering include the mimicking of natural extracellular matrices (ECMs) in the 3D microenvironment. Dendrimers are unimolecular architects that can incorporate a variety of biological and/or chemical substances in a 3D architecture to actively support the scaffold microenvironment during cell growth. Here, we review the use of dendritic delivery systems in tissue engineering. We discuss the available literature, highlighting the 3D architecture and preparation of these nanoscaffolds, and also review challenges to, and advances in, the use dendrimers in tissue engineering. Advances in the manufacturing of dendritic nanoparticles and scaffold architectures have resulted in the successful incorporation of dendritic scaffolds in tissue engineering.
authors.affiliation: Faculty of Pharmacy, Lincoln University College, Kuala Lumpur, Malaysia.
authors.forename: Bapi
authors.initials: B
authors.lastname: Gorain
authors.affiliation: TIT College of Pharmacy, Technocrats Institute of Technology, Anand Nagar, Bhopal, MP 462021, India.
authors.forename: Muktika
authors.initials: M
authors.lastname: Tekade
authors.affiliation: The International Medical University, School of Pharmacy, Department of Pharmaceutical Technology, Jalan Jalil Perkasa 19, 57000 Kuala Lumpur, Malaysia.
authors.forename: Prashant
authors.initials: P
authors.lastname: Kesharwani
authors.affiliation: Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Iyer
authors.affiliation: National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, Palaj, Opposite Air Force Station, Gandhinagar 382355, Gujarat, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Kalia
authors.affiliation: National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, Palaj, Opposite Air Force Station, Gandhinagar 382355, Gujarat, India. Electronic address: rakeshtekade@gmail.com.
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Tekade
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage; D050091:Dendrimers / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage*; D012038:Regeneration / Q000187:drug effects; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D050091:Dendrimers