title: [Comparison of age-based clinical and abnormal immune parameters in patients with Henoch-Schönlein purpura].
abstract: Objective:To explore age-based clinical and immune parameters in Henoch-Schönlein purpura (HSP) to determine clinically useful markers reflecting disease characteristic.Methods:A cohort of 502 patients with HSP were enrolled into this retrospective study to evaluate their clinical and immune data.Results:Majority HSP cases occurred at age ≤14 years and showed significant immune imbalances of ESR, CD3(+) cells, CD4(+) cells, CD3(-)CD16(+)CD56(+) cells, CD4(+)/CD8(+) cells, IgG, IgA, IgM, IgE, complements C3/C4 and ASO in the acute phase. Compared to patients aged >14 years, symptoms of joint were more frequent at disease onset in patients aged ≤14 years (20.8%vs7.6%,χ(2)=13.547,P<0.001) , and involvement of digestive tract and joint were also more frequent (57.4%vs33.8%,χ(2)=24.106,P<0.001; 55.9%vs32.5%,χ(2)=23.768,P<0.001, respectively) , but not for involvement of kidney (21.4%vs51.3%,χ(2)=42.440,P<0.001) . The patients aged ≤14 years had distinct immune state, reductions of CD3(+) cells, CD4(+) cells and IgG were more frequent than patients aged >14 years, also increase of ASO (33.1%vs20.0%,χ(2)=6.656,P=0.010) , but not increase of IgA (2.6%vs39.4%,χ(2)=15.582,P<0.001) . In addition, reduction of IgG and increase of IgE were positively associated with digestive tract involvement (P<0.001,P=0.001, respectively) , reduction of CD3(+)CD4(+) cells and normal IgM were positively associated with joint involvement (P=0.004,P=0.003, respectively) , increase of CD3(+)CD8(+) cells and normal CD3(+) cells were positively associated with kidney involvement (P=0.032,P=0.014, respectively) .Conclusion:HSP showed significant immune imbalance in the acute phase, patients between aged ≤14 and >14 years had distinct clinical and immune characteristic, and abnormal immune parameters were significantly associated with organ involvements.
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.forename: P J
authors.initials: PJ
authors.lastname: Guo
authors.forename: P L
authors.initials: PL
authors.lastname: Liu
authors.forename: H R
authors.initials: HR
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Xiao
authors.forename: X P
authors.initials: XP
authors.lastname: Li
authors.forename: J B
authors.initials: JB
authors.lastname: Huang
authors.affiliation: Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Zheng
mesh_terms: D000293:Adolescent; D002452:Cell Count; D002648:Child; D006801:Humans; D011695:IgA Vasculitis; D007070:Immunoglobulin A; D007668:Kidney; D012189:Retrospective Studies
chemical_list: D007070:Immunoglobulin A
keywords: Complement C3; Complement C4; Immunoglobulin; Lymphocyte subset; Purpura, Schoenlein-Henoch