title: [Hypofractionated radiation therapy for localized prostate cancer (first experience)].
abstract: This paper presents a study of 74 prostate cancer patients divided into 2 groups (study group and comparison group). The comparison group patients (n=50) were treated with radiation therapy in standard fractionated mode, while study group patients (n=24) underwent hypofractionated radiation therapy (STD 7.5 Gy; TTD 37.5 Gy). Early radiation-induced complications occurred only in the comparison group patients. Late radiation-induced complications were observed in 4 and 8 patients in the study group and the comparison group, respectively. Significant statistic differences in quality of life between groups were found in patients with excellent (FET; p=0.0145) and satisfactory (FET; p=0.03) well-being. Hypofractionated radiation therapy is safe given that the necessary technical and clinical conditions are observed. It significantly reduces treatment time and enables quickly bringing a course of radiation therapy to radical doses. This is a noninvasive treatment that significantly reduces risks and cost of procedures.
authors.affiliation: Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Center of Oncology and Radiotherapy.
authors.forename: T G
authors.initials: TG
authors.lastname: Vorob'eva
authors.affiliation: Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Center of Oncology and Radiotherapy.
authors.forename: I V
authors.initials: IV
authors.lastname: Bednyj
authors.affiliation: Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Center of Oncology and Radiotherapy.|Novosibirsk State Medical University.
authors.forename: E A
authors.initials: EA
authors.lastname: Drobjazgin
authors.affiliation: Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Center of Oncology and Radiotherapy.
authors.forename: E S
authors.initials: ES
authors.lastname: Polovnikov
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019583:Dose Fractionation, Radiation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*
keywords: hypofractionated mode; prostate cancer; radiation therapy