title: Anticipating hyperthermic efficiency of magnetic colloids using a semi-empirical model: a tool to help medical decisions.
abstract: Magnetic hyperthermia, a modality that uses radio frequency heating assisted with single-domain magnetic nanoparticles, is becoming established as a powerful oncological therapy. Much improvement in nanomaterials development, to enhance their heating efficiency by tuning the magnetic colloidal properties, has been achieved. However, methodological standardization to accurately and univocally determine the colloidal properties required to numerically reproduce a specific heating efficiency using analytical expressions still holds. Thus, anticipating the hyperthermic performances of magnetic colloids entails high complexity due to polydispersity, aggregation and dipolar interactions always present in real materials to a greater or lesser degree. Here, by numerically simulating the experimental results and using real biomedical aqueous colloids, we analyse and compare several approaches to reproduce experimental specific absorption rate values. Then, we show that the relaxation time, determined using a representative mean activation energy consistently derived from four independent experiments accurately reproduces experimental heating efficiencies. Moreover, the so-derived relaxation time can be used to extrapolate the heating performance of the magnetic nanoparticles to the other field conditions within the framework of the linear response theory. We thus present a practical tool that may truly aid the design of medical decisions.
authors.affiliation: Instituto de Física La Plata (IFLP-CONICET), Departamento de Física, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), c.c. 67, 1900 La Plata, Argentina. raap@fisica.unlp.edu.ar.
authors.forename: M B
authors.initials: MB
authors.lastname: Fernández van Raap
authors.affiliation: Instituto de Física La Plata (IFLP-CONICET), Departamento de Física, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), c.c. 67, 1900 La Plata, Argentina. raap@fisica.unlp.edu.ar.
authors.forename: D F
authors.identifier: http://orcid.org/0000-0001-7078-2368
authors.initials: DF
authors.lastname: Coral
authors.affiliation: Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193 Bellaterra, Catalonia, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Yu
authors.affiliation: Instituto de Física La Plata (IFLP-CONICET), Departamento de Física, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), c.c. 67, 1900 La Plata, Argentina. raap@fisica.unlp.edu.ar.
authors.forename: G A
authors.initials: GA
authors.lastname: Muñoz
authors.affiliation: Instituto de Física La Plata (IFLP-CONICET), Departamento de Física, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), c.c. 67, 1900 La Plata, Argentina. raap@fisica.unlp.edu.ar.
authors.forename: F H
authors.initials: FH
authors.lastname: Sánchez
authors.affiliation: Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193 Bellaterra, Catalonia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Roig