title: Effect of Surgical Intraocular Pressure Lowering on Peripapillary and Macular Vessel Density in Glaucoma Patients: An Optical Coherence Tomography Angiography Study.
abstract: OBJECTIVE
  To measure the influence of surgically induced intraocular pressure lowering on peripapillary and macular vessel density in glaucoma patients using optical coherence tomography angiography.
  
  
  METHODS
  Twenty-one eyes of 21 patients with open-angle glaucoma scheduled for filtering surgery were enrolled prospectively. Using optical coherence tomography angiography, vessel density was quantified within the peripapillary and macular regions, before and 1 month after filtering surgery. Change in vessel density was calculated for all analyzed areas.
  
  
  RESULTS
  One month after surgery, the mean intraocular pressure reduction was 44.2%±4.8% (range, 15.2% to 77.1%). The mean change in vessel density for the whole peripapillary area was 0.065±0.88% (P=0.788). In the macular region, the mean change in vessel density was -0.022%±0.691% (P=0.405) with significant changes only within the inferotemporal area of patients with predominantly superior visual field defects (-1.86%±1.43%, P=0.024).
  
  
  CONCLUSIONS
  Optical coherence tomography angiography allowed very limited measurement of intraocular pressure lowering-induced changes on the vessel density of the peripapillary and macular regions in glaucoma patients.
authors.affiliation: *Department of Ophthalmology III, Quinze-Vingts Hospital †Quinze-Vingts Hospital, DHU Sight Restore, INSERM-DHOS CIC §INSERM, U968 ∥Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Institut de la Vision ¶CNRS, UMR_7210 #Department of Ophthalmology, Ambroise Paré Hospital, APHP, University of Paris Saclay, Saclay, France ‡Department of Clinical Sciences, Ophthalmology Institute, University of Turin, Turin, Italy.
authors.forename: Pierre
authors.initials: P
authors.lastname: Zéboulon
authors.forename: Pierre-Maxime
authors.initials: PM
authors.lastname: Lévêque
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Brasnu
authors.forename: Vittoria
authors.initials: V
authors.lastname: Aragno
authors.forename: Pascale
authors.initials: P
authors.lastname: Hamard
authors.forename: Christophe
authors.initials: C
authors.lastname: Baudouin
authors.forename: Antoine
authors.initials: A
authors.lastname: Labbé
mesh_terms: D000368:Aged; D000072226:Computed Tomography Angiography; D005260:Female; D018463:Filtering Surgery; D005902:Glaucoma, Open-Angle / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000098:blood supply*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology; D012171:Retinal Vessels / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014794:Visual Fields / Q000502:physiology