title: Efficacy and Therapeutic Potential of Curcumin Against Sepsis-Induced Chronic Lung Injury in Male Albino Rats.
abstract: The present study investigates curcumin effect against sepsis-induced chronic lung injury (CLI) of male albino rats. Rats were grouped into four groups such rats undergoing a sham cecal ligature puncture (CLP), rats undergoing CLP, rats undergoing CLP and treated with saline and rats undergoing CLP and treated with curcumin (100 mg/kg bwt). After 45 days of treatment, bronchoalveolar fluid (BALF), blood and lung tissues were collected from the each animal. The total protein content, wet and dry (W/D) weight of lung tissues and some inflammatory cells in the BALF were measured. Histopathological analysis was carried out to investigate the alteration of the cellular architecture of lung tissues. Lipid peroxidation malondialdehyde (MDA), superoxide dismutase (SOD) and myeloperoxidase (MPO) levels were determined. Cytokines such as interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-a) and macrophage inhibitory factor (MIF) were measured in the BALF. Curcumin administration significantly reduced CLP-induced inflammation and pulmonary edema. Curcumin treatment is significantly reduced MPO activity, and inflammatory cell accumulation in the BALF and also protein level, MDA, SOD, and W/D ratio were significantly reduced in the lung tissues. Also, curcumin reduced the expression of IL-A, TNF-a and MIF levels in the lung tissues. Histopathological study revealed the significant reduction of CLP-induced CLI in the curcumin-treated male albino rats. Taking all these data together, it is concluded that curcumin can act as a suitable therapeutic agent against CLP-induced CLI of male albino rats.
authors.affiliation: Xiang-Dong Li, Emergency center, The Second Hospital of Dalian Medical University, NO.467 Zhongshan Road, ShaHekou District, Dalian, Liaoning 116023, China. E-mail: L_yf2013@163.com.
authors.forename: Y-F
authors.initials: YF
authors.lastname: Liu
authors.forename: C-W
authors.initials: CW
authors.lastname: Yang
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: S-G
authors.initials: SG
authors.lastname: Sui
authors.forename: X-D
authors.initials: XD
authors.lastname: Li
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001992:Bronchoalveolar Lavage Fluid; D002432:Cecum / Q000601:surgery; D003474:Curcumin / Q000494:pharmacology*; D016209:Interleukin-8 / Q000378:metabolism; D019746:Intramolecular Oxidoreductases / Q000378:metabolism; D015227:Lipid Peroxidation; D008168:Lung / Q000473:pathology; D055370:Lung Injury / Q000473:pathology* / Q000517:prevention & control*; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D018805:Sepsis / Q000473:pathology*; D013482:Superoxide Dismutase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; C508606:CXCL8 protein, human; D016209:Interleukin-8; D008263:Macrophage Migration-Inhibitory Factors; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D009195:Peroxidase; D013482:Superoxide Dismutase; D019746:Intramolecular Oxidoreductases; C515599:Mif protein, rat; D003474:Curcumin
keywords: Curcumin; chronic; inflammation; rats; sepsis