title: Chylothorax and central vein thrombosis, an under-recognized association: a case series.
abstract: Chylothorax is defined as the presence of chyle in the pleural cavity. Central vein thrombosis is an under-recognized cause of chylothorax in the adult population and is commonly related to central venous catheterization. Case 1 illustrates a patient with AIDS and disseminated tuberculosis with left chylothorax and central vein thrombosis after a month of antituberculosis therapy. Case 2 was a patient with advanced seminoma who presented with left chylothorax and central vein thrombosis while on chemotherapy. Chylothorax resolved with anticoagulation for both cases. Case 3 was a lymphoma patient with central vein thrombosis who developed chylothorax during chemotherapy. Chylothorax resolved with the continuation of anticoagulation and did not recur despite his progressive underlying lymphoma. There was no central venous catheterization in any of these three cases. These cases illustrate the unique association of central vein thrombosis and chylothorax and the importance of anticoagulation in its management.
authors.affiliation: Respiratory Medicine Unit, Department of Medicine Sarawak General Hospital Kuching Malaysia.
authors.forename: Sze Shyang
authors.identifier: 0000-0002-1457-9231
authors.initials: SS
authors.lastname: Kho
authors.affiliation: Respiratory Medicine Unit, Department of Medicine Sarawak General Hospital Kuching Malaysia.
authors.forename: Siew Teck
authors.initials: ST
authors.lastname: Tie
authors.affiliation: Respiratory Medicine Unit, Department of Medicine Sarawak General Hospital Kuching Malaysia.
authors.forename: Swee Kim
authors.initials: SK
authors.lastname: Chan
authors.affiliation: Respiratory Medicine Unit, Department of Medicine Sarawak General Hospital Kuching Malaysia.
authors.forename: Mei Ching
authors.initials: MC
authors.lastname: Yong
authors.affiliation: Department of Diagnostic Imaging Sarawak General Hospital Kuching Malaysia.
authors.forename: Sing Ling
authors.initials: SL
authors.lastname: Chai
authors.affiliation: Department of Radiotherapy and Oncology Unit Sarawak General Hospital Kuching Malaysia.
authors.forename: Pei Jye
authors.initials: PJ
authors.lastname: Voon
keywords: Anticoagulation; chylothorax; malignancy; thrombosis; tuberculosis