title: Effects of renal denervation on vascular remodelling in patients with heart failure and preserved ejection fraction: A randomised control trial.
abstract: OBJECTIVE
  To assess the effect of renal denervation (RDT) on micro- and macro-vascular function in patients with heart failure with preserved ejection fraction (HFpEF).
  
  
  METHODS
  A prospective, randomised, open-controlled trial with blinded end-point analysis.
  
  
  METHODS
  A single-centre London teaching hospital.
  
  
  METHODS
  Twenty-five patients with HFpEF who were recruited into the RDT-PEF trial.
  
  
  METHODS
  Macro-vascular: 24-h ambulatory pulse pressure, aorta distensibilty (from cardiac magnetic resonance imaging (CMR), aorta pulse wave velocity (CMR), augmentation index (peripheral tonometry) and renal artery blood flow indices (renal MR). Micro-vascular: endothelial function (peripheral tonometry) and urine microalbuminuria.
  
  
  RESULTS
  At baseline, 15 patients were normotensive, 9 were hypertensive and 1 was hypotensive. RDT did not lower any of the blood pressure indices. Though there was evidence of abnormal vascular function at rest, RDT did not affect these at 3 or 12 months follow-up.
  
  
  CONCLUSIONS
  RDT did not improve markers of macro- and micro-vascular function.
authors.affiliation: Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College, London, UK.
authors.forename: Hitesh C
authors.initials: HC
authors.lastname: Patel
authors.affiliation: Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College, London, UK.
authors.forename: Carl
authors.initials: C
authors.lastname: Hayward
authors.affiliation: Department of Cardiac MRI, Royal Brompton Hospital, London, UK.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Keegan
authors.affiliation: Department of Cardiac MRI, Royal Brompton Hospital, London, UK.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Gatehouse
authors.affiliation: Department of Cardiology, St Thomas' Hospital, London, UK.
authors.forename: Ronak
authors.initials: R
authors.lastname: Rajani
authors.affiliation: Department of Non-Invasive Cardiology, Royal Brompton Hospital, London, UK.
authors.forename: Rajdeep S
authors.initials: RS
authors.lastname: Khattar
authors.affiliation: Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College, London, UK.
authors.forename: Raad H
authors.initials: RH
authors.lastname: Mohiaddin
authors.affiliation: Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College, London, UK; Department of Cardiology, Ealing Hospital, Southall, UK.
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Rosen
authors.affiliation: Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College, London, UK.
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Lyon
authors.affiliation: Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College, London, UK.
authors.forename: Carlo
authors.initials: C
authors.lastname: di Mario
keywords: Renal denervation; endothelial function; heart failure with preserved ejection fraction; pulse wave velocity; vascular function