title: A split-brain case study on the hemispheric lateralization of inhibitory control.
abstract: Understanding the neurobiological mechanisms underlying inhibitory control is crucial given its role in various disease states and substance abuse/misuse. Neuroimaging research examining inhibitory control has yielded conflicting results on the relative importance of the left and right hemisphere during successful inhibition of a motor response. In the current study, a split-brain patient was examined in order to assess the independent inhibitory capabilities of each hemisphere. The patient's right hemisphere exhibited superior inhibitory ability compared to his left hemisphere on three inhibitory control tasks. Although inferior to the right, the left hemisphere inhibited motor responses on inhibitory trials in all three tasks. The results from this study support the dominance of the right hemisphere in inhibitory control.
authors.affiliation: Department of Psychiatry, University of Vermont, Burlington, VT, USA. Electronic address: ndalbert@uvm.edu.
authors.forename: Nicholas
authors.initials: N
authors.lastname: D'Alberto
authors.affiliation: Psychological & Brain Sciences, Dartmouth College, Hanover, NH, USA.
authors.forename: Margaret
authors.initials: M
authors.lastname: Funnell
authors.affiliation: Department of Psychiatry, University of Vermont, Burlington, VT, USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Potter
authors.affiliation: Department of Psychiatry, University of Vermont, Burlington, VT, USA.
authors.forename: Hugh
authors.initials: H
authors.lastname: Garavan
mesh_terms: D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009483:Neuropsychological Tests; D011930:Reaction Time; D050812:Split-Brain Procedure
keywords: Go/No-Go; Response inhibition; Stop signal