title: Assessment of the efficacy and safety of fampridine.
abstract: OBJECTIVE
  Assessment of the efficacy and safety of fampridine for walking improvement in adult patients with multiple sclerosis.
  
  
  METHODS
  A descriptive retrospective study of all patients who initiated treatment with fampridine between March, 2014 and February, 2015. Efficacy was assessed through the 25-foot walk test and the 12-item walking scale for multiple sclerosis. It was reviewed whether patients had suffered any of the most frequent adverse effects described in the pivotal clinical trial.
  
  
  RESULTS
  Six patients were included, with a 66.7% response rate. At 3-6 months, the mean change in walking speed (compared to baseline) was 39.32% and there was a mean improvement of 15 points in the walking scale. Only one patient presented adverse effects.
  
  
  CONCLUSIONS
  The results obtained are encouraging, particularly when fampridine is the only drug currently approved to control such a disabling symptom as instability while walking.
authors.affiliation: Pharmacy Unit. Hospital da Costa. EOXI Lugo, Monforte e Cervo.. beatriz.mejuto.perez.del.molino@sergas.es.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Mejuto
authors.affiliation: Pharmacy Unit. Hospital da Costa. EOXI Lugo, Monforte e Cervo.. beatriz.mejuto.perez.del.molino@sergas.es.
authors.forename: Paloma
authors.initials: P
authors.lastname: Castellano
authors.affiliation: Pharmacy Unit. Hospital da Costa. EOXI Lugo, Monforte e Cervo.. beatriz.mejuto.perez.del.molino@sergas.es.
authors.forename: Concepción
authors.initials: C
authors.lastname: Castro
authors.affiliation: Neurology Unit. Hospital da Costa. EOXI Lugo, Monforte e Cervo.. beatriz.mejuto.perez.del.molino@sergas.es.
authors.forename: Luis Manuel
authors.initials: LM
authors.lastname: López
mesh_terms: D015761:4-Aminopyridine / Q000009:adverse effects* / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D026902:Potassium Channel Blockers / Q000009:adverse effects* / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome; D016138:Walking
chemical_list: D026902:Potassium Channel Blockers; D015761:4-Aminopyridine