title: A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China.
abstract: Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents.
authors.affiliation: The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous' Region, Urumqi, Xinjiang, 830002, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Shen
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
authors.forename: Junming
authors.initials: J
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
authors.forename: Zhengyuan
authors.initials: Z
authors.lastname: Su
authors.affiliation: School of Medicine, Wuhan University of Science and Technology, Wuhan, 430065, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
authors.forename: Jinliang
authors.initials: J
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.affiliation: The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous' Region, Urumqi, Xinjiang, 830002, China.
authors.forename: Qiguo
authors.initials: Q
authors.lastname: Wang
authors.affiliation: The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous' Region, Urumqi, Xinjiang, 830002, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Hu
authors.affiliation: The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous' Region, Urumqi, Xinjiang, 830002, China. xjsyzhang@163.com.
authors.forename: Yujiang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Deng
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral / Q000032:analysis; D002681:China; D016000:Cluster Analysis; D005838:Genotype; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000145:classification* / Q000302:isolation & purification* / Q000502:physiology; D026863:Ixodidae / Q000821:virology*; D008807:Mice, Inbred BALB C; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D056189:Viral Tropism; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral; D012367:RNA, Viral
keywords: Crimean-Congo hemorrhagic fever virus (CCHFV); genotype; newborn mice; phylogenetic analysis