title: Sebaceous carcinoma of the breast: a case report.
abstract: BACKGROUND
  Sebaceous carcinoma of the breast is a distinct variant of invasive ductal carcinoma. It is rare and only several cases have been reported.
  
  
  METHODS
  An 80-year-old woman noted bloody discharge from her left nipple and palpated a lump in her left breast. Ultrasonography revealed a 19-mm mass in the left breast. Fine-needle aspiration suggested invasive ductal carcinoma. Partial mastectomy and sentinel lymph node biopsy were performed. On histological examination, the tumor revealed solid growth of small, round uniform cells with clear cytoplasm, partially intermingled with vacuolated cells indicative of sebaceous differentiation. The tumor cells contained abundant Sudan Black B-positive lipid droplets in the cytoplasm, and they were immunohistochemically positive for adipophilin. They were negative for estrogen receptor, progesterone receptor, and androgen receptor; positive for cytokeratin 7 and Ber-EP4; and partially positive for epithelial membrane antigen. Based on these findings, the patient was diagnosed with sebaceous carcinoma of the breast.
  
  
  CONCLUSIONS
  We diagnosed a rare case of sebaceous carcinoma of the breast.
authors.affiliation: Department of Surgery, Suwa Red Cross Hospital, Suwa, Japan.|Present address: Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Pathology, Suwa Red Cross Hospital, Suwa, Japan. pathology@suwa.jrc.or.jp.
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Department of Surgery, Suwa Red Cross Hospital, Suwa, Japan.|Koyama Clinic, Suwa, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koyama
authors.affiliation: Department of Surgery, Suwa Red Cross Hospital, Suwa, Japan.|Present address: Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Kanai
authors.affiliation: Department of Pathology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.|Present address: Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Suzuko
authors.initials: S
authors.lastname: Moritani
authors.affiliation: Department of Pathology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
authors.forename: Shu
authors.initials: S
authors.lastname: Ichihara
keywords: Breast carcinoma; Immunohistochemistry; Lipid staining; Sebaceous carcinoma