title: Correlation of compliance to statin therapy with lipid profile and serum HMGCoA reductase levels in dyslipidemic patients.
abstract: BACKGROUND
  The efficacy of statin therapy may be lost or vary with reduction in compliance and intensity of statin therapy.
  
  
  OBJECTIVE
  To study and correlate the quantitative effect of compliance on lipid profile and 3-hydroxyl-3-methylglutaryl coenzyme A reductase (HMGCoA-R) levels in dyslipidemic patients.
  
  
  METHODS
  Compliance to different intensity of statin therapy assessed by pill count was correlated with serum levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides (TG), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and HMGCoA-R.
  
  
  RESULTS
  Out of 200 patients, 160 received moderate intensity statin therapy whereas 40 were on high intensity statin therapy. The overall mean compliance of patients was 56.7%. The compliance of patients on moderate intensity statin therapy was higher (56.8%) than those on high intensity (56.4%) (p=0.92). There was significant inverse correlation (p<0.05) between compliance and TC, TG, LDL-C and HMGCoA-R levels and positive correlation (p<0.05) with HDL-C levels. The mean serum HMGCoA-R levels did not fall below 9-10ng/mL when compliance to either moderate or high intensity statin therapy was increased above 60%.
  
  
  CONCLUSIONS
  It is appropriate to improve the compliance to existing statin therapy than switching over to higher intensity statin therapy. Estimation of HMGCoA-R levels may be explored as a surrogate marker to monitor and assess the compliance of patients to statin therapy.
authors.affiliation: Department of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.
authors.forename: Abhinav
authors.initials: A
authors.lastname: Grover
authors.affiliation: Department of Medicine, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India. Electronic address: harmeetrehan@hotmail.com.
authors.forename: Harmeet Singh
authors.initials: HS
authors.lastname: Rehan
authors.affiliation: Department of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.
authors.forename: Lalit Kumar
authors.initials: LK
authors.lastname: Gupta
authors.affiliation: Department of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.
authors.forename: Madhur
authors.initials: M
authors.lastname: Yadav
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000069059:Atorvastatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics; D008055:Lipids / Q000097:blood*; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D011446:Prospective Studies; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids; D000068718:Rosuvastatin Calcium; D000069059:Atorvastatin
keywords: Atorvastatin; Compliance; Dyslipidemia; HMGCoA reductase; Rosuvastatin