title: Evaluating segmental liver function using T1 mapping on Gd-EOB-DTPA-enhanced MRI with a 3.0 Tesla.
abstract: Assessing the liver function provides valuable information to evaluate surgical risk and plan accordingly. Current studies focus on whole liver function evaluation. However, assessment of segmental liver function is equally important in the clinical practice. The purpose of this study was to investigate whether Gd-EOB-DTPA-enhanced MRI can evaluate the liver function of each segment by using T1 mapping at 3 Tesla MRI.
  
  
  
  One hundred three patients were classified into one of 4 groups: a normal liver function (NLF) group (n = 38), a liver cirrhosis with Child-Pugh A (LCA) group (n = 33), a liver cirrhosis with Child-Pugh B (LCB) group (n = 21), and a liver cirrhosis with Child-Pugh C (LCC) group (n = 11). All patients underwent Gd-EOB-DTPA-enhanced MRI scans. T1 relaxation times were measured on the liver superimposing T1 mapping images. Reduction rate (△%) of T1 relaxation time of the liver parenchyma were calculated.
  
  
  
  After 20 min of Gd-EOB-DTPA enhancement, the T1 relaxation time of all liver segments in the LCC group were different from those in all the other groups, and more liver segments from the LCB and LCA groups different from the NLF group (p < 0.05). For the LCB group, the areas under the receiver operating characteristic curves (AUCs) of different liver segments for hepatobiliary phase (HBP) were 0.654-0.904 on T1 relaxation time, and 0.709-0.905 on △%. For the LCC group, the AUCs of different liver segments for HBP were 0.842-0.997 on T1 relaxation time, and 0.887-0.990 on △%.
  
  
  
  For LCB patients, segmental liver function evaluation is possible using Gd-EOB-DTPA-enhanced MRI T1 mapping. For LCC patients, all liver segments can be used to evaluate liver function and both T1 relaxation time and the △% of T1 relaxation time have good diagnostic performance.
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.|Department of Radiology, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, People's Republic of China.
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Zhou
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
authors.forename: Li-Ling
authors.initials: LL
authors.lastname: Long
authors.affiliation: Department of Radiology, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, People's Republic of China.
authors.forename: Wei-Jia
authors.initials: WJ
authors.lastname: Qiu
authors.affiliation: Department of Radiology, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, People's Republic of China.
authors.forename: Ge
authors.initials: G
authors.lastname: Cheng
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Huang
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
authors.forename: Teng-Fei
authors.initials: TF
authors.lastname: Yang
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China. huangzhk1205@sina.com.
authors.forename: Zhong-Kui
authors.initials: ZK
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019786:Gadolinium DTPA / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
keywords: Gd-EOB-DTPA; Liver function; MRI; T1 mapping