title: Drug releasing nanoplatforms activated by alternating magnetic fields.
abstract: The use of an alternating magnetic field (AMF) to generate non-invasively and spatially a localized heating from a magnetic nano-mediator has become very popular these last years to develop magnetic hyperthermia (MH) as a promising therapeutic modality already used in the clinics. AMF has become highly attractive this last decade over others radiations, as AMF allows a deeper penetration in the body and a less harmful ionizing effect. In addition to pure MH which induces tumor cell death through local T elevation, this AMF-generated magneto-thermal effect can also be exploited as a relevant external stimulus to trigger a drug release from drug-loaded magnetic nanocarriers, temporally and spatially. This review article is focused especially on this concept of AMF induced drug release, possibly combined with MH. The design of such magnetically responsive drug delivery nanoplatforms requires two key and complementary components: a magnetic mediator which collects and turns the magnetic energy into local heat, and a thermoresponsive carrier ensuring thermo-induced drug release, as a consequence of magnetic stimulus. A wide panel of magnetic nanomaterials/chemistries and processes are currently developed to achieve such nanoplatforms. This review article presents a broad overview about the fundamental concepts of drug releasing nanoplatforms activated by AMF, their formulations, and their efficiency in vitro and in vivo. This article is part of a Special Issue entitled "Recent Advances in Bionanomaterials" Guest Editors: Dr. Marie-Louise Saboungi and Dr. Samuel D. Bader.
authors.affiliation: Institut de Physique et Chimie des Matériaux de Strasbourg, UMR 7504 CNRS, Université de Strasbourg, 23, rue du Loess, 67034 Strasbourg, France. Electronic address: damien.mertz@ipcms.unistra.fr.
authors.forename: Damien
authors.initials: D
authors.lastname: Mertz
authors.affiliation: Laboratoire de Chimie des Polymères Organiques (LCPO), CNRS UMR 5629, Université de Bordeaux, Bordeaux-INP, Pessac 33607, Cedex, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Sandre
authors.affiliation: Institut de Physique et Chimie des Matériaux de Strasbourg, UMR 7504 CNRS, Université de Strasbourg, 23, rue du Loess, 67034 Strasbourg, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bégin-Colin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D004735:Energy Transfer; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007700:Kinetics; D060526:Magnetic Fields; D008280:Magnetics / Q000379:methods*; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D012995:Solubility
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers