title: Fundus Autofluorescence Imaging in the Assessment of Acute Zonal Occult Outer Retinopathy.
abstract: OBJECTIVE
  To evaluate the fundus autofluorescence (FAF) findings in eyes with acute zonal occult outer retinopathy (AZOOR) and the relationships between the FAF, spectral-domain optical coherence tomography (SD-OCT), and Humphrey visual field (HVF) findings.
  
  
  METHODS
  We performed a retrospective review of the clinical features and FAF, SD-OCT, and HVF findings of 23 eyes of 22 consecutive patients with AZOOR. The mean deviation (MD) values of HVF were compared between areas of normal and abnormal FAF.
  
  
  RESULTS
  FAF abnormalities were detected in 21 (91.3%) eyes, with diffuse hyperautofluorescence in 19 (82.6%) eyes and mottling autofluorescence in 2 (8.7%) eyes. In all eyes with FAF abnormality, a clear boundary between the affected and unaffected retina was observed. SD-OCT revealed loss of ellipsoid zone in retinal regions corresponding to the dysfunctional areas demonstrated by HVF. The FAF abnormality also corresponded with the boundaries demonstrated by SD-OCT and/or HVF. The differences in HVF MD values between areas with normal and abnormal FAF in AZOOR eyes were significantly higher than in normal unaffected eyes (p < 0.05).
  
  
  CONCLUSIONS
  FAF abnormalities were detected in most AZOOR eyes, and the former corresponded to the abnormal retinal regions revealed by SD-OCT and HVF. The findings suggested that FAF is a useful investigation for the assessment of AZOOR.
authors.affiliation: Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Libin
authors.initials: L
authors.lastname: Jiang
authors.forename: Weiyu
authors.initials: W
authors.lastname: Yan
authors.forename: Wenbin
authors.initials: W
authors.lastname: Wei
authors.forename: Timothy Y Y
authors.initials: TYY
authors.lastname: Lai
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology*; D012189:Retrospective Studies; D012607:Scotoma / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D014794:Visual Fields; D000080363:White Dot Syndromes; D055815:Young Adult