title: Sequencing Errors Rife in Genome Databases.
abstract: Low-frequency genetic variants in cancer genome datasets are often simply artifacts of DNA damage introduced by routine sample preparation, not tumor-driving mutations. A new algorithm found that around three quarters of all the samples in The Cancer Genome Atlas contain large numbers of these sequencing errors.
mesh_terms: D000465:Algorithms; D030541:Databases, Genetic; D014644:Genetic Variation; D015894:Genome, Human / Q000235:genetics*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D017422:Sequence Analysis, DNA