title: Non-invasive evaluation of portal hypertension using ultrasound elastography.
abstract: Portal hypertension (PH) leads to serious complications, such as bleeding from gastroesophageal varices, ascites and portosystemic encephalopathy in patients with chronic liver disease (CLD). Gold standard methods for assessing PH and its complications include the measurement of hepatic venous pressure gradient and endoscopy; however, these are invasive, expensive and not available at all centres. Therefore, non-invasive alternatives have been the subject of extensive investigation over the last 20years. The present review focuses on the role of ultrasound elastography - a novel group of non-invasive techniques used to measure stiffness in target organs. In the context of CLD these methods are used to identify the presence of PH, its severity, and the risk of PH-related complications. The rationale, accumulated evidence, advantages and limitations of liver and spleen stiffness measurements evaluated by different ultrasound elastography techniques in patients with advanced CLD is discussed. Recent data regarding the use of ultrasound elastography techniques in patients with non-cirrhotic forms of PH are also described.
authors.affiliation: Swiss Liver Center, Hepatology, University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Switzerland. Electronic address: annalisa.berzigotti@insel.ch.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Berzigotti
mesh_terms: D054459:Elasticity Imaging Techniques / Q000379:methods* / Q000639:trends; D004932:Esophageal and Gastric Varices / Q000209:etiology; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008099:Liver / Q000503:physiopathology; D011237:Predictive Value of Tests; D013154:Spleen / Q000000981:diagnostic imaging / Q000503:physiopathology
keywords: Advanced chronic liver disease; Cirrhosis; Decompensation; Non-invasive; Varices