title: Preparation of magnetic melamine-formaldehyde resin and its application to extract nonsteroidal anti-inflammatory drugs.
abstract: Magnetic melamine-formaldehyde resin was prepared via water-in-oil emulsification approach by entrapping Fe3O4magnetic nanoparticles as the core. The preparation of the magnetic resin was optimized by investigating the amount of polyethylene glycol 20000 and Fe3O4nanoparticles, the concentration of the catalyst (hydrochloric acid), as well as the mechanical stirring rate. The prepared material was characteristic of excellent anion-exchange capacity, good water wettability, and proper magnetism. Its application was demonstrated by magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs coupled to high performance liquid chromatography-UV analysis. Under the optimal conditions, the proposed method showed broad linear range of 1-5000 ng mL-1of milk and urine samples, satisfactory reproducibility with intra-day and inter-day relative standard deviations less than 12.4% and 9.7%, respectively, and low limits of detection of 0.2 ng mL-1for the studied nonsteroidal anti-inflammatory drugs. The developed method was successfully used for the determination of the nonsteroidal anti-inflammatory drugs in spiked urine and milk samples. The magnetic melamine-formaldehyde resin was promising for the sample pretreatment of acidic analytes via anion-exchange interaction with convenient operation from complex sample matrix. Graphical abstract Magnetic solid-phase extraction based on melamine-formaldehyde resin.
authors.affiliation: Tongji School of Pharmacy, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan, Hubei, 430030, China.
authors.forename: Shu-Wen
authors.initials: SW
authors.lastname: Xue
authors.affiliation: Tongji School of Pharmacy, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan, Hubei, 430030, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Tongji School of Pharmacy, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan, Hubei, 430030, China. xulpharm@mails.tjmu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000302:isolation & purification* / Q000652:urine*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005557:Formaldehyde / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D008280:Magnetics / Q000379:methods; D059346:Magnets / Q000737:chemistry*; D008892:Milk / Q000737:chemistry*; D008958:Models, Molecular; D015203:Reproducibility of Results; D012117:Resins, Synthetic / Q000737:chemistry; D052616:Solid Phase Extraction / Q000379:methods*; D014227:Triazines / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012117:Resins, Synthetic; D014227:Triazines; D005557:Formaldehyde; C011907:melamine
keywords: Magnetic solid-phase extraction; Melamine-formaldehyde resin; Nonsteroidal anti-inflammatory drugs; Sample pretreatment