title: Effects of Blood Purification on Serum Levels of Inflammatory Cytokines and Cardiac Function in a Rat Model of Sepsis.
abstract: OBJECTIVE
  The study aimed to explore the effects of blood purification (BP) on serum levels of inflammatory cytokines and cardiac function in a rat model of sepsis.
  
  
  METHODS
  A rat model of sepsis was established by cecal ligation and puncture. All rats were divided into the normal control, sham operation, model, sham treatment, and BP treatment groups. Cardiac functions, inflammatory cytokines, myocardial enzymes, pathological score of cardiac muscle tissue, and myocardial apoptosis of rats in each group were compared.
  
  
  RESULTS
  Sepsis rats had higher serum levels of inflammatory cytokines and lower cardiac function than those in the normal control and sham operation groups. Compared with the model and sham treatment groups, improved cardiac functions, decreased inflammatory cytokines, myocardial enzymes, pathological score, and myocardial apoptosis and mortality were observed in the BP treatment group.
  
  
  CONCLUSIONS
  BP may reduce serum levels of inflammatory cytokines and improve cardiac function of sepsis rats.
authors.affiliation: Department of Hematology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, PR China.
authors.forename: Cong-Meng
authors.initials: CM
authors.lastname: Lin
authors.forename: Cun-Rong
authors.initials: CR
authors.lastname: Chen
authors.forename: Xue-Qiong
authors.initials: XQ
authors.lastname: Wu
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Ren
authors.forename: Shao-Zhen
authors.initials: SZ
authors.lastname: Chen
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Luo
authors.forename: Xu-Qiao
authors.initials: XQ
authors.lastname: Mei
authors.forename: Lv-Ying
authors.initials: LY
authors.lastname: Shen
authors.forename: Meng-Xian
authors.initials: MX
authors.lastname: Guo
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Ma
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood*; D004195:Disease Models, Animal; D006321:Heart / Q000502:physiology*; D006439:Hemodynamics; D018836:Inflammation Mediators / Q000097:blood; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018805:Sepsis / Q000097:blood* / Q000628:therapy; D016060:Sorption Detoxification; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators