title: Proliferative and Differentiation Potential of Multipotent Mesenchymal Stem Cells Cultured on Biocompatible Polymer Scaffolds with Various Physicochemical Characteristics.
abstract: Biocompatibility of film and fibrous scaffolds from polylactide-based polymers and the relationship between their architecture and the functional characteristics of mesenchymal stem cells were studied. Cell culturing on polylactide-based film and fibrous matrixes did not deteriorate cell morphology and their proliferation and differentiation capacities. The rate of cell proliferation and penetration in microporous 3D matrices with the same porosity parameters and pore size depended on their spatial organization. The above materials can be used as scaffolds for mesenchymal stem cells for creation of tissue engineering implants. The scaffold size and structure should be determined by the defects in the organs in which the regeneration processes have to be stimulated.
authors.affiliation: National Research Center Kurchatov Institute, Moscow, Russia. allrodina@yandex.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Rodina
authors.affiliation: National Research Center Kurchatov Institute, Moscow, Russia.
authors.forename: T Kh
authors.initials: TK
authors.lastname: Tenchurin
authors.affiliation: A. I. Burnazyan Federal Medical and Biophysical Center, Federal Medical-Biological Agency, Moscow, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Saprykin
authors.affiliation: National Research Center Kurchatov Institute, Moscow, Russia.
authors.forename: A D
authors.initials: AD
authors.lastname: Shepelev
authors.affiliation: National Research Center Kurchatov Institute, Moscow, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Mamagulashvili
authors.affiliation: National Research Center Kurchatov Institute, Moscow, Russia.
authors.forename: T E
authors.initials: TE
authors.lastname: Grigor'ev
authors.affiliation: National Research Center Kurchatov Institute, Moscow, Russia.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Moskaleva
authors.affiliation: National Research Center Kurchatov Institute, Moscow, Russia.
authors.forename: S N
authors.initials: SN
authors.lastname: Chvalun
authors.affiliation: National Research Center Kurchatov Institute, Moscow, Russia.
authors.forename: S E
authors.initials: SE
authors.lastname: Severin
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D019902:Chondrocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology*; D016062:Porosity; D061251:Primary Cell Culture; D044968:Regenerative Medicine; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide)
keywords: differentiation; mesenchymal stem cells; polylactide; regenerative medicine; scaffolds