title: Development of drug delivery systems for taxanes using ionic gelation of carboxyacyl derivatives of chitosan.
abstract: Nanoparticles of two chitosan derivatives - N-succinyl-chitosan (SC) and N-glutaryl-chitosan (GC) - were developed as passive transport systems for taxanes (paclitaxel and docetaxel) using an ionic gelation technique with sodium tripolyphosphate. These nanoparticles had an apparent hydrodynamic diameter of 300-350nm, a ζ-potential of 25-31mV, an encapsulation efficiency of 21-26%, and a drug loading efficiency of 6-13%. DLS and SLS analysis shows that the nanoparticles have a unimodal size distribution and spherical form. Drug release kinetics of the taxane-loaded nanoparticles demonstrates that more than 50% of the loaded taxane could be released upon the degradation of the nanoparticles after targeted delivery. The drug-loaded SC and GC nanoparticles exhibit high cytotoxicity towards AGS cancer cell lines and their antitumor activity is consequently enhanced when compared with free taxanes.
authors.affiliation: Institute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoi pr. VO 31, St. Petersburg 199004, Russian Federation; Institute of Chemistry, St. Petersburg State University, Universitetskii pr. 26, Petrodvorets, St. Petersburg 198504, Russian Federation. Electronic address: yury_skorik@mail.ru.
authors.forename: Yury A
authors.initials: YA
authors.lastname: Skorik
authors.affiliation: Institute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoi pr. VO 31, St. Petersburg 199004, Russian Federation.
authors.forename: Anton A
authors.initials: AA
authors.lastname: Golyshev
authors.affiliation: Institute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoi pr. VO 31, St. Petersburg 199004, Russian Federation; Institute of Chemistry, St. Petersburg State University, Universitetskii pr. 26, Petrodvorets, St. Petersburg 198504, Russian Federation.
authors.forename: Andreii S
authors.initials: AS
authors.lastname: Kritchenkov
authors.affiliation: Institute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoi pr. VO 31, St. Petersburg 199004, Russian Federation.
authors.forename: Ekaterina R
authors.initials: ER
authors.lastname: Gasilova
authors.affiliation: Institute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoi pr. VO 31, St. Petersburg 199004, Russian Federation.
authors.forename: Daria N
authors.initials: DN
authors.lastname: Poshina
authors.affiliation: Amrita Centre for Nanosciences & Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Viswa Vidyapeetam University, Kochi 682041, India.
authors.forename: Amal J
authors.initials: AJ
authors.lastname: Sivaram
authors.affiliation: Amrita Centre for Nanosciences & Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Viswa Vidyapeetam University, Kochi 682041, India.
authors.forename: Rangasamy
authors.initials: R
authors.lastname: Jayakumar
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D043823:Taxoids / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D043823:Taxoids; D048271:Chitosan
keywords: Docetaxel; Drug delivery; Glutaryl-chitosan; Ionic gelation; Paclitaxel; Succinyl-chitosan