title: A review of drugs in development for the personalized treatment of head and neck squamous cell carcinoma.
abstract: BACKGROUND
  Head and neck squamous cell carcinoma remains a highly morbid and fatal disease, with poor survival rates among patients with advanced and recurrent disease. Recent advances in next generation sequencing, targeted therapeutics, and precision medicine trials are expanding treatment options for head and neck cancers; thus greater awareness of this rapidly evolving field is important.
  
  
  METHODS
  Recent next-generation sequencing studies in head and neck squamous cell carcinoma, targeted therapy clinical trials involving head and neck squamous cell carcinoma.
  This review discusses the current state of head and neck cancer treatment, and considerations and implications for the incorporation of personalized medicine and targeted therapy for head and neck cancers in a dynamic clinical landscape.
authors.affiliation: Head and Neck Translational Oncology Laboratory, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Otolaryngology-Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, MI.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Birkeland
authors.affiliation: Head and Neck Translational Oncology Laboratory, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Otolaryngology-Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, MI; Division of Medical Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.
authors.forename: Paul L
authors.initials: PL
authors.lastname: Swiecicki
authors.affiliation: Head and Neck Translational Oncology Laboratory, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Otolaryngology-Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, MI.
authors.forename: J Chad
authors.initials: JC
authors.lastname: Brenner
authors.affiliation: Head and Neck Translational Oncology Laboratory, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Otolaryngology-Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, MI; Center for Bioethics and Social Sciences in Medicine, University of Michigan Medical School, Ann Arbor, MI.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Shuman
keywords: HNSCC; head and neck cancer; personalized medicine; precision medicine; targeted therapy