title: [Research Progress on Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation -Review].
abstract: Thrombocytopenia is a major complication following allogeneic stem cell transplantation(allo-HSCT). Overall survival(OS) and disease-free survival(DFS) of patients with thrombocytopenia were lower than those without thrombocytopenia. Lower platelet counts before conditioning, graft-versus-host disease(GVHD) and cytomegalovirus(CMV) infection are adverse factors for the patiens with thrombocytopenia. Bone marrow microenvironment may be involved in the pathogenesis. Thrombopoietin(TPO) and mesenchymal stem cells can improve the platelet counts. In this review the definition, prognosis, pathogenesis and potential therapy for thrombocytopenia after allo-HSCT are summarized.
authors.affiliation: Department of Hematology, Changhai Hospital,Institute of Hematologic Disease of Chinese PLA, Second Military Medical University, Shanghai 200433, China.
authors.forename: Ai-Jie
authors.initials: AJ
authors.lastname: Huang
authors.affiliation: Department of Hematology, Changhai Hospital,Institute of Hematologic Disease of Chinese PLA, Second Military Medical University, Shanghai 200433, China.
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Hu
authors.affiliation: Department of Hematology, Changhai Hospital,Institute of Hematologic Disease of Chinese PLA, Second Military Medical University, Shanghai 200433, China. E-mail: jmwang@medmail.com.cn.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Wang
mesh_terms: D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000150:complications; D006086:Graft vs Host Disease / Q000150:complications; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D013921:Thrombocytopenia / Q000209:etiology* / Q000628:therapy; D019172:Transplantation Conditioning