title: Cancer: a new role for non-canonical Hippo signaling.
abstract: The molecular mechanisms governing self-renewal and differentiation of the mammary epithelium are incompletely defined; a better understanding of the events implicated in the specification and expansion of luminal progenitors is of particular importance as many breast cancers originate from their transformation. Britschgi et al. found that, in addition to phosphorylating and inactivating YAP, LATS functions as a scaffold to facilitate estrogen receptor-α ubiquitylation by the E3 ligase CRL4 and consequently suppresses luminal progenitor specification and expansion.
authors.affiliation: Research and Early Development, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Cooper
authors.affiliation: Department of Cancer Biology and David H Koch Center for Applied Research of Genitourinary Cancers, UT MD Anderson Cancer Center, Houston, TX 77230, USA.
authors.forename: Filippo G
authors.initials: FG
authors.lastname: Giancotti
mesh_terms: D001940:Breast; D002454:Cell Differentiation; D047628:Estrogen Receptor alpha; D000090683:Hippo Signaling Pathway; D006801:Humans; D017346:Protein Serine-Threonine Kinases; D015398:Signal Transduction
chemical_list: D047628:Estrogen Receptor alpha; C092745:LATS1 protein, human; D017346:Protein Serine-Threonine Kinases