title: Total intravenous anesthesia produces outcomes superior to those with combined intravenous-inhalation anesthesia for laparoscopic gynecological surgery at high altitude.
abstract: Objective We compared efficacy and adverse outcomes following totally intravenous anesthesia (TIVA) versus combined intravenous-inhalation anesthesia (CIVIA) on hemodynamics and postoperative recovery following laparoscopic gynecological (LG) surgery at high altitudes. Methods We enrolled 80 ASA I or II patients scheduled for LG surgery and randomly assigned them to TIVA with propofol (group P, n = 40) or CIVIA with isoflurane (group I, n = 40). Mean arterial pressure, heart rate, pulse oxygen saturation, and partial pressure of end-tidal carbon dioxide were measured at various time points. Outcome measures were interval to spontaneous ventilation, eye opening, return to consciousness, extubation, operating room duration. Intraoperative awareness and postoperative nausea/vomiting were assessed at follow-up. Results No differences in hemodynamic parameters were detected in either group. Group P had a significantly shorter postoperative anesthetic recovery time and lower incidence of postoperative nausea/vomiting. Conclusion TIVA is superior to CIVIA for GL surgery at high altitudes.
authors.affiliation: 1 Department of Anesthesiology, Zhujiang Hospital, Southern medical University, Guangzhou, Guangdong, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.affiliation: 1 Department of Anesthesiology, Zhujiang Hospital, Southern medical University, Guangzhou, Guangdong, China.|2 Department of Anesthesiology, the First People's Hospital of Kashi, Kashi, Xinjiang, China.
authors.forename: Shuqin
authors.initials: S
authors.lastname: Zhou
authors.affiliation: 3 Departement of Anesthesiology, People's Hospital of Linzhi Area, Tibet, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yang
authors.affiliation: 4 Department of Hepatobiliary Surgery II, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Li
authors.affiliation: 1 Department of Anesthesiology, Zhujiang Hospital, Southern medical University, Guangzhou, Guangdong, China.
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: 5 Department of Pathology, Shantou University Medical College, Shantou, Guangdong, China.
authors.forename: Guohong
authors.initials: G
authors.lastname: Zhang
authors.affiliation: 1 Department of Anesthesiology, Zhujiang Hospital, Southern medical University, Guangzhou, Guangdong, China.
authors.forename: Shiyuan
authors.initials: S
authors.lastname: Xu
authors.affiliation: 4 Department of Hepatobiliary Surgery II, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Peng
mesh_terms: D000293:Adolescent; D000328:Adult; D000531:Altitude; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D013509:Gynecologic Surgical Procedures; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D058926:Intraoperative Awareness / Q000175:diagnosis; D007530:Isoflurane; D010535:Laparoscopy; D008875:Middle Aged; D061646:Operative Time; D010146:Pain / Q000503:physiopathology / Q000517:prevention & control*; D020250:Postoperative Nausea and Vomiting / Q000175:diagnosis / Q000503:physiopathology; D015742:Propofol; D011446:Prospective Studies; D018609:Tibet; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D007530:Isoflurane; D015742:Propofol
keywords: TIVA; anesthesia; gynecological surgery; intravenous–inhalation anesthesia; laparoscopy; postoperative recovery