title: Regenerative capacity of autologous stem cell transplantation in elderly: a report of biomedical outcomes.
abstract: The occurrence of chronic diseases such as neurological, metabolic and cardiovascular degenerative disorders increases with age. Cell therapy is an emerging approach to the treatment of these conditions. Of particular interest is the application of autologous stem cells because it eliminates post-transplantation immune rejection and there are less ethical concerns associated with their use. The regenerative capacity of stem cells harvested from elderly people is however controversial. In this review, we analyze if self-renewal potential, differentiation capability and expression of stemness genes in stem cells collected from elderly patients validate their application in clinical trials and examine the results.
authors.affiliation: Tecnologico de Monterrey, Escuela Nacional de Medicina, Morones Prieto 3000 Pte, CP64710, Monterrey, Mexico.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Gonzalez-Garza
authors.affiliation: Tecnologico de Monterrey, Escuela Nacional de Medicina, Morones Prieto 3000 Pte, CP64710, Monterrey, Mexico.
authors.forename: Delia Elva
authors.initials: DE
authors.lastname: Cruz-Vega
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000628:therapy*; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D044968:Regenerative Medicine; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D014182:Transplantation, Autologous
keywords: adult stem cells; aging; autologous transplantation; clinical trial; elderly patients