title: CuBr-Catalyzed Aerobic Decarboxylative Cycloaddition for the Synthesis of Indolizines under Solvent-Free Conditions.
abstract: An efficient synthesis of diversified indolizine derivatives was developed via CuBr-catalyzed reaction of pyridines, methyl ketones and alkenoic acids under solvent-free conditions in oxygen atmosphere. This synthesis involves cascade processes of copper-catalyzed bromination of the methyl ketone, 1,3-dipolar cycloaddition of the pyridinium ylide with the alkenoic acid, followed by oxidative decarboxylation and dehydrogenative aromatization of the primary cycloadduct. By this protocol, a wide range of indoliznes with different substitution patterns were selectively prepared in one pot from simple substrates in good to excellent yields.
authors.affiliation: Jiangsu Key Laboratory of Green Synthesis for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, Jiangsu P. R. China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Wang
authors.affiliation: Jiangsu Key Laboratory of Green Synthesis for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, Jiangsu P. R. China.
authors.forename: Junwen
authors.initials: J
authors.lastname: Han
authors.affiliation: Jiangsu Key Laboratory of Green Synthesis for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, Jiangsu P. R. China.|School of Environmental Science & Engineering, Nanjing University of Information Science & Technology , Nanjing 210044, P. R. China.
authors.forename: Jinwei
authors.initials: J
authors.lastname: Sun
authors.affiliation: Jiangsu Key Laboratory of Green Synthesis for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, Jiangsu P. R. China.
authors.forename: Yun
authors.identifier: 0000-0001-5783-4848
authors.initials: Y
authors.lastname: Liu