title: Prognostic value of the C-reactive protein/albumin ratio in patients with laryngeal squamous cell carcinoma.
abstract: OBJECTIVE
  The present study was designed to retrospectively evaluate the prognostic value of the C-reactive protein/albumin (CRP/ALB) ratio in laryngeal squamous cell carcinoma (LSCC).
  
  
  METHODS
  One hundred and twenty-nine newly diagnosed LSCC patients admitted between May 2006 and October 2011 were retrospectively reviewed. Their serum CRP and ALB were quantified preoperatively. The relationship between the CRP/ALB ratio and the clinicopathologic features was analyzed. Receiver operating characteristic curve was used to calculate the prognostic value of the CRP/ALB ratio. Then, the Cox proportional hazards model was used in univariate and multivariate analyses to identify significant prognostic factors associated with disease-free survival and overall survival.
  
  
  RESULTS
  The cutoff value for CRP/ALB ratio was 0.047. An elevated CRP/ALB ratio was significantly associated with nodal metastasis, late disease stage, and recurrence. Also, high values of CRP/ALB ratio were significant predictors for poor overall survival and disease-free survival on multivariate analysis.
  
  
  CONCLUSIONS
  Pretreatment CRP/ALB ratio may be a significant prognostic marker in LSCC.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Shi-Tong
authors.initials: ST
authors.lastname: Yu
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Cai
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Faya
authors.initials: F
authors.lastname: Liang
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Han
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Renhui
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Huang
keywords: C-reactive protein/albumin ratio; laryngeal squamous cell carcinoma; prognosis; survival