title: Multiwalled carbon nanotubes for drug delivery: Efficiency related to length and incubation time.
abstract: Batches of oxidized multiwalled carbon nanotubes differing in length were adopted to prepare two drug delivery systems (DDS) loaded with doxorubicin. The different internalization of the two batches, verified by atomic emission spectroscopy onto cell lysates, was also confirmed by the different toxicity of the same DDS loaded with doxorubicin. In vitro experiments evidenced, after 48h of incubation, the superior efficacy of the shortest nanotubes. However, upon prolonging the incubation time up to 72h the difference in efficiency was minimized due to the spontaneous release of doxorubicin by the non-internalized long nanotubes.
authors.affiliation: Chemistry Department "Ugo Schiff", Università di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino (Fi), Italy.
authors.forename: Niccolò
authors.initials: N
authors.lastname: Sciortino
authors.affiliation: Chemistry Department "Ugo Schiff", Università di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino (Fi), Italy. Electronic address: stefanofedeli@gmail.com.
authors.forename: Stefano
authors.initials: S
authors.lastname: Fedeli
authors.affiliation: Department of Experimental and Clinical Biomedical Sciences, Università di Firenze, Viale Morgagni 50, 50134 Firenze, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Paoli
authors.affiliation: Chemistry Department "Ugo Schiff", Università di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino (Fi), Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Brandi
authors.affiliation: Department of Experimental and Clinical Biomedical Sciences, Università di Firenze, Viale Morgagni 50, 50134 Firenze, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Chiarugi
authors.affiliation: Chemistry Department "Ugo Schiff", Università di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino (Fi), Italy.
authors.forename: Mirko
authors.initials: M
authors.lastname: Severi
authors.affiliation: Chemistry Department "Ugo Schiff", Università di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino (Fi), Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Cicchi
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D061986:MCF-7 Cells; D037742:Nanotubes, Carbon / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000903:Antibiotics, Antineoplastic; D037742:Nanotubes, Carbon; D004317:Doxorubicin
keywords: 8-(4-Nitrophenyl) Bodipy (PubChem CID: 44471706); BODIPY (PubChem CID: 25058173); Biotin (PubChem CID: 171548); Biotin alkyne (PubChem CID: 89434015); Doxorubicin; Doxorubicin (PubChem CID: 31703); Drug delivery systems; Multiwalled carbon nanotubes; Ultracentrifugation