title: In Silico Design of Optimal Dissolution Kinetics of Fe-Doped ZnO Nanoparticles Results in Cancer-Specific Toxicity in a Preclinical Rodent Model.
abstract: Cancer cells have unique but widely varying characteristics that have proven them difficult to be treated by classical therapeutics and calls for novel and selective treatment options. Nanomaterials (NMs) have been shown to display biological effects as a function of their chemical composition, and the extent and exact nature of these effects can vary between different biological environments. Here, ZnO NMs are doped with increasing levels of Fe, which allows to finely tune their dissolution rate resulting in significant differences in their biological behavior on cancer or normal cells. Based on in silico analysis, 2% Fe-doped ZnO NMs are found to be optimal to cause selective cancer cell death, which is confirmed in both cultured cells and syngeneic tumor models, where they also reduce metastasis formation. These results show that upon tuning NM chemical composition, NMs can be designed as a targeted selective anticancer therapy.
authors.affiliation: Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.
authors.forename: Bella B
authors.initials: BB
authors.lastname: Manshian
authors.affiliation: Foundation Institute of Materials Science (IWT), Department of Production Engineering, University of Bremen, 28359, Bremen, Germany.
authors.forename: Suman
authors.initials: S
authors.lastname: Pokhrel
authors.affiliation: Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.
authors.forename: Uwe
authors.initials: U
authors.lastname: Himmelreich
authors.affiliation: Department of Chemistry, University of Tartu, Ravila, 14a, 50411, Estonia.
authors.forename: Kaido
authors.initials: K
authors.lastname: Tämm
authors.affiliation: Department of Chemistry, University of Tartu, Ravila, 14a, 50411, Estonia.
authors.forename: Lauri
authors.initials: L
authors.lastname: Sikk
authors.affiliation: Departament d'Enginyeria Quimica, Universitat Rovira i Virgili, Av. Paisos Catalans, 26, 43007, Tarragona, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernández
authors.affiliation: Departament d'Enginyeria Informatica i Matematiques, Universitat Rovira i Virgili, Av. Paisos Catalans 26, 43007, Tarragona, Spain.
authors.forename: Robert
authors.initials: R
authors.lastname: Rallo
authors.affiliation: Institute of Technology, University of Tartu, Nooruse 1, Tartu, 50411, Estonia.
authors.forename: Tarmo
authors.initials: T
authors.lastname: Tamm
authors.affiliation: Foundation Institute of Materials Science (IWT), Department of Production Engineering, University of Bremen, 28359, Bremen, Germany.
authors.forename: Lutz
authors.initials: L
authors.lastname: Mädler
authors.affiliation: Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.
authors.forename: Stefaan J
authors.initials: SJ
authors.lastname: Soenen
mesh_terms: D000818:Animals; D002460:Cell Line; D006367:HeLa Cells; D006801:Humans; D007501:Iron / Q000737:chemistry*; D007700:Kinetics; D051379:Mice; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D049329:Nanostructures / Q000737:chemistry*; D012377:Rodentia; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D007501:Iron; D015034:Zinc Oxide
keywords: ZnO; nanomedicine; nanoparticle; toxic-by-design; tumor therapy