title: [Protein molecular aging: which role in physiopathology?]
abstract: Protein molecular aging corresponds to all modifications affecting proteins during their biological life, which lead to the alteration of their structural and functional properties. This phenomenon participates in cell and tissue aging and is therefore involved in the aging of human organism. It is also amplified in various chronic diseases such as diabetes mellitus or chronic kidney disease, where it participates in the development of long-term complications. This review aims at describing the main reactions responsible for molecular aging, their impact on protein properties and the parameters which could influence this phenomenon. A general scheme explaining its role in physiopathology is also proposed.
authors.affiliation: Université de Reims Champagne-Ardenne, CNRS UMR 7369, Laboratoire de Biochimie Médicale et Biologie Moléculaire, UFR de Médecine, 51, rue Cognacq-Jay, 51095 Reims Cedex, France - Centre Hospitalier Universitaire de Reims, Pôle de Biologie Médicale et Pathologie, Laboratoire de Biologie et de Recherche Pédiatriques, 45, rue Cognacq-Jay, 51092 Reims Cedex, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Jaisson
authors.affiliation: Université de Reims Champagne-Ardenne, CNRS UMR 7369, Laboratoire de Biochimie Médicale et Biologie Moléculaire, UFR de Médecine, 51, rue Cognacq-Jay, 51095 Reims Cedex, France - Centre Hospitalier Universitaire de Reims, Pôle de Biologie Médicale et Pathologie, Laboratoire de Biologie et de Recherche Pédiatriques, 45, rue Cognacq-Jay, 51092 Reims Cedex, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Desmons
authors.affiliation: Université de Reims Champagne-Ardenne, CNRS UMR 7369, Laboratoire de Biochimie Médicale et Biologie Moléculaire, UFR de Médecine, 51, rue Cognacq-Jay, 51095 Reims Cedex, France.
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Gorisse
authors.affiliation: Université de Reims Champagne-Ardenne, CNRS UMR 7369, Laboratoire de Biochimie Médicale et Biologie Moléculaire, UFR de Médecine, 51, rue Cognacq-Jay, 51095 Reims Cedex, France - Centre Hospitalier Universitaire de Reims, Pôle de Biologie Médicale et Pathologie, Laboratoire de Biologie et de Recherche Pédiatriques, 45, rue Cognacq-Jay, 51092 Reims Cedex, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gillery
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000502:physiology*; D004194:Disease / Q000209:etiology*; D006031:Glycosylation; D006801:Humans; D010084:Oxidation-Reduction; D050050:Protein Carbonylation; D011489:Protein Denaturation; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology
chemical_list: D011506:Proteins