title: The research on lapatinib in autophagy, cell cycle arrest and epithelial to mesenchymal transition via Wnt/ErK/PI3K-AKT signaling pathway in human cutaneous squamous cell carcinoma.
abstract: Cutaneous squamous cell carcinoma (cSCC) contributes to one of most common types of skin cancer. Epidermal growth factor receptor (EGFR) activation has been investigated to be associated with the development of cSCC. Lapatinib is an inhibitor targeting HER2/neu and EGFR pathway. We found that lapatinib can inhibit proliferation by enhancing apoptosis of human cSCC cell lines. The cSCC cell cycle distribution could be arrested in G2/M phase after lapatinib treatment. In the in vitro experiment, we found that lapatinib interrupted PI3K/AKT/mTOR signaling pathway in human cSCC cells. Furthermore, lapatinib could suppress epithelial to mesenchymal transition (EMT) via Wnt/ErK/PI3K-AKT signaling pathway to represent a promising anticancer drug for cSCC treatment.
authors.affiliation: Department of Burns and Plastic Surgery, General Hospital, Ningxia Medical University, Yinchuan, People's Republic of China.; Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Yao
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA.; Department of Dermatology, General Hospital, Ningxia Medical University.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Shang
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Zhou
authors.affiliation: Department of Colorectal Surgery, General Hospital, Ningxia Medical University.
authors.forename: Yin-Xue
authors.initials: YX
authors.lastname: Yang
authors.affiliation: Department of Burns and Plastic Surgery, General Hospital, Ningxia Medical University, Yinchuan, People's Republic of China.
authors.forename: Yin-Sheng
authors.initials: YS
authors.lastname: Wu
authors.affiliation: Department of Burns and Plastic Surgery, General Hospital, Ningxia Medical University, Yinchuan, People's Republic of China.
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Guan
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA.; Department of Pharmacy, General Hospital, Ningxia Medical University, Yinchuan.
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA.
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Zhou
authors.affiliation: Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Wei
keywords: Lapatinib; cutaneous squamous cell carcinoma (cSCC); epithelial to mesenchymal transition.; proliferation