title: Immediately Functioning Grafts from Brain-Dead Donors Treated with Extracorporeal Membrane Oxygenation.
abstract: A brain-dead donor experienced repeated cardiac arrests followed by severe hypotension requiring multiple vasoactive agents. These events were associated with severe lactic acidosis and dysregulated kidney function in the donor. A 10-hour treatment with extracorporeal membranous oxygenation was instituted, which was able to hemodynamically stabilize the donor. This treatment protocol resulted in the procurement of 2 viable kidney grafts transplanted into 2 recipients, who had immediate kidney graft function and excellent serum creatinine levels upon hospital discharge. These results are all the more significant considering that both cases involved long cold ischemia times, and one of the recipients had diabetes and was receiving his second kidney graft.
authors.affiliation: From the Saudi Center for Organ Transplantation, Riyadh, Saudi Arabia.
authors.forename: Faissal A M
authors.initials: FAM
authors.lastname: Shaheen
authors.forename: Mohamed
authors.initials: M
authors.lastname: Shalabi
authors.forename: Ahmed
authors.initials: A
authors.lastname: Zain
authors.forename: Mahmood
authors.initials: M
authors.lastname: Hasanain
authors.forename: Abdulla
authors.initials: A
authors.lastname: Al Sayyari
mesh_terms: D000328:Adult; D001926:Brain Death; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation; D008297:Male; D020127:Recovery of Function; D013997:Time Factors; D014019:Tissue Donors