title: Asymmetric Synthesis of α-Trifluoromethyl Pyrrolidines through Organocatalyzed 1,3-Dipolar Cycloaddition Reaction.
abstract: The optically active α-trifluoromethyl pyrrolidines have been achieved through organocatalyzed 1,3-dipolar cycloaddition reaction first. With diphenylprolinol trimethylsilyl ether as catalyst and in the presence of 3,5-dinitrobenzoic acid, the reaction of trifluoroethylamine-derived ketimine with 2-enals gave α-trifluoromethyl pyrrolidines bearing three contiguous stereogenic centers in excellent diastereoselectivies, stereoselectivities, and yields.
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Zhenghao
authors.initials: Z
authors.lastname: Dong
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Boyu
authors.initials: B
authors.lastname: Li
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Wang
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Wenjin
authors.identifier: 0000-0003-2566-7322
authors.initials: W
authors.lastname: Yan
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Kairong
authors.initials: K
authors.lastname: Wang
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.|State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, People's Republic of China.
authors.forename: Rui
authors.identifier: 0000-0002-4719-9921
authors.initials: R
authors.lastname: Wang