title: Assessment of changes in insulin requirement in patients of type 2 diabetes mellitus on maintenance hemodialysis.
abstract: BACKGROUND
  Hemodialysis improves insulin sensitivity. Currently, there is no recommendation for the adjustment of insulin dose on dialysis day and nondialysis day in diabetic patients. This study was undertaken to determine the variations in insulin requirement based on blood glucose levels on dialysis days and nondialysis days in type 2 diabetic patients with chronic kidney disease on maintenance hemodialysis.
  
  
  METHODS
  Twenty-eight diabetic patients on hemodialysis were recruited into the study after obtaining written informed consent and approval from Azeezia Ethics Committee. Capillary blood glucose levels, just before dialysis and 2 h after dialysis, were checked and compared with fasting and postprandial glucose levels on-off dialysis days.
  
  
  RESULTS
  Mean age of the patients was 59.5 (±2.3) years. The average duration of dialysis was 20.2 months. There was significant (35.8%) decrease in blood glucose levels 2 h after dialysis in comparison to predialysis levels (from mean level of 258-165 mg/dl). The decrease in the blood glucose levels from predialysis level to 2 h postdialysis level was statistically significant (P< 0.001). Both sets of data showed "strong" positive correlation withr= 0.657 and 0.849. The blood glucose levels on the day of dialysis were significantly lower than the off-day values.
  
  
  CONCLUSIONS
  Diabetic patients with end-stage renal disease on hemodialysis have lower capillary blood glucose levels postdialysis. This has to be addressed clinically to prevent hypoglycemic episodes by reducing exogenous insulin administration on the day of dialysis.
authors.affiliation: Department of Pharmacology, Azeezia Institute of Medical Sciences, Kollam, Kerala, India.
authors.forename: M J
authors.initials: MJ
authors.lastname: Sudha
authors.affiliation: Department of Medical Undergraduate Student, Azeezia Institute of Medical Sciences, Kollam, Kerala, India.
authors.forename: Halma S
authors.initials: HS
authors.lastname: Salam
authors.affiliation: Department of Anatomy, Azeezia Institute of Medical Sciences, Kollam, Kerala, India.
authors.forename: S
authors.initials: S
authors.lastname: Viveka
authors.affiliation: Department of Pharmacology, Azeezia Institute of Medical Sciences, Kollam, Kerala, India.
authors.forename: A L
authors.initials: AL
authors.lastname: Udupa
keywords: Capillary blood glucose level; end-stage renal disease; hemodialysis; insulin requirement; on-day and off-day