title: Evaluation of the Impact of a New Synthetic Vitamin E-Bonded Membrane on the Hypo-Responsiveness to the Erythropoietin Therapy in Hemodialysis Patients: A Multicenter Study.
abstract: BACKGROUND
  Oxidative stress has been related to hypo-response to erythropoiesis-stimulating agents (ESAs) in hemodialysis (HD) patients. The aim of this study was to verify whether vitamin E (ViE) on a synthetic polysulfone dialyzer can improve ESA responsiveness.
  
  
  METHODS
  This controlled, multicenter study involved 93 HD patients on stable ESA therapy, who were randomized to either ViE-coated polysulfone dialyzer or to a low-flux synthetic dialyzer. The primary outcome measure was the change in ESA resistance index (ERI) from baseline.
  
  
  RESULTS
  Mean ERI decreased in the ViE group by 1.45 IU/kg*g/dl and increased in the control group by 0.53 IU/kg*g/dl, with a mean difference of 1.98 IU/kg*g/dl (p = 0.001 after adjusting for baseline ERI, as foreseen by the study protocol). Baseline ERI was inversely related to its changes during follow-up only in the control group (R2 = 0.29).
  
  
  CONCLUSIONS
  The ViE dialyzer can improve ESA response in HD patients. Changes in ERI during follow-up are independent from baseline ERI only in the ViE group. Video Journal Club 'Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=453442.
authors.affiliation: Department of Nephrology and Dialysis of Alessandro Manzoni Hospital, Lecco, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Locatelli
authors.forename: Simeone
authors.initials: S
authors.lastname: Andrulli
authors.forename: Sara Maria
authors.initials: SM
authors.lastname: Viganò
authors.forename: Massimo
authors.initials: M
authors.lastname: Concetti
authors.forename: Sauro
authors.initials: S
authors.lastname: Urbini
authors.forename: Franca
authors.initials: F
authors.lastname: Giacchino
authors.forename: Roberto
authors.initials: R
authors.lastname: Broccoli
authors.forename: Filippo
authors.initials: F
authors.lastname: Aucella
authors.forename: Maria
authors.initials: M
authors.lastname: Cossu
authors.forename: Paolo
authors.initials: P
authors.lastname: Conti
authors.forename: Laura
authors.initials: L
authors.lastname: Fattori
authors.forename: Giorgio
authors.initials: G
authors.lastname: Punzo
authors.forename: Daniela
authors.initials: D
authors.lastname: Angelini
authors.forename: Marco
authors.initials: M
authors.lastname: Peruzzini
authors.forename: Salvatore
authors.initials: S
authors.lastname: Di Giulio
authors.forename: Marta
authors.initials: M
authors.lastname: Piroddi
authors.forename: Francesco
authors.initials: F
authors.lastname: Galli
authors.forename: Lucia
authors.initials: L
authors.lastname: Del Vecchio
mesh_terms: D000368:Aged; D000740:Anemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D004921:Erythropoietin / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome; D014810:Vitamin E / Q000737:chemistry
chemical_list: D008567:Membranes, Artificial; D004921:Erythropoietin; D014810:Vitamin E