title: Genetic analysis of FGF20 in Chinese patients with Parkinson's disease.
abstract: Sequence variants in fibroblast growth factor 20 (FGF20) have been reported to be associated with Parkinson's disease (PD). We genotyped the rs591323 variant in a total of 2220 Han Chinese subjects, including 1051 patients with sporadic PD and 1169 controls, to investigate the association between rs591323 and the risk of PD. In addition, we also conducted a stratified analysis according to age at onset of PD and compared the clinical characteristics of AA + AG subjects with GG subjects. In this study, we confirmed that the A allele of rs591323 in FGF20 reduces the risk of developing sporadic PD (P = 0.013). Additionally, subjects with the AA + AG genotype have a reduced risk compared to individuals with the GG genotype (P = 0.024). This association was significant among females (P = 0.036), but was not significant among males (P = 0.266). Furthermore, no significant association was observed among either the early-onset PD group (P = 0.051) or the late-onset PD group (P = 0.187). Moreover, we demonstrated that the AA + AG subjects could not be distinguished from the GG subjects based on their clinical features. Our study is the first to demonstrate that FGF20 (rs591323) is associated with a lower risk of PD in a Southern Han Chinese population from mainland China.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Sun
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Lan
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Nan-Nan
authors.initials: NN
authors.lastname: Li
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Zhong-Jiao
authors.initials: ZJ
authors.lastname: Lu
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Li
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. qrongpeng@126.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Peng
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: C416003:FGF20 protein, human; D005346:Fibroblast Growth Factors
keywords: FGF20; Parkinson’s disease; Variation; rs591323