title: Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx.
abstract: The changes for oropharyngeal lesions in the 2017 edition of the WHO/IARC Classification of Head and Neck Tumours reference book are dramatic and significant, largely due to the growing impact of high risk human papillomavirus (HPV). The upcoming edition divides tumours of the oral cavity and oropharynx into separate chapters, classifies squamous cell carcinomas (SCC) of the oropharynx on the basis of HPV status, abandons the practice of histologic grading for oropharyngeal SCCs that are HPV positive, recognizes small cell carcinoma of the oropharynx, and combines polymorphous low grade adenocarcinoma and cribriform adenocarcinoma of tongue and minor salivary glands under the single term "polymorphous adenocarcinoma." This review not only calls attention to these changes, but describes the rationale driving these changes and highlights their implications for routine clinical practice.
authors.affiliation: Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.|Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.|Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
authors.forename: William H
authors.initials: WH
authors.lastname: Westra
authors.affiliation: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. james.lewis@vanderbilt.edu.|Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, TN, USA. james.lewis@vanderbilt.edu.
authors.forename: James S
authors.initials: JS
authors.lastname: Lewis
mesh_terms: D006801:Humans; D009959:Oropharyngeal Neoplasms / Q000145:classification* / Q000473:pathology; D014944:World Health Organization
keywords: Human papillomavirus; Oropharynx; Polymorphous adenocarcinoma; Small cell carcinoma; Squamous cell carcinoma; World Health Organization