title: RISK OF SILICONE OIL AS VITREOUS TAMPONADE IN PARS PLANA VITRECTOMY: A Systematic Review and Meta-Analysis.
abstract: OBJECTIVE
  The authors examined the differences between silicone oil and other vitreous tamponades or placebo in performing pars plana vitrectomy.
  
  
  METHODS
  This review and meta-analysis was conducted in accordance with the PRISMA guidelines. Seven databases and the reference lists of the retrieved randomized controlled trial articles were searched to identify eligible studies. The primary outcomes were the rate of redetachment after endotamponade removal, the rate of reoperation, and poor visual acuity. The secondary outcomes were adverse events and quality of life related to postoperative position.
  
  
  RESULTS
  Ten articles (12 trials) were included. There were no significant differences between silicone oil and other agents in most of the primary and second outcomes. Only the risk of hypotony was found to be significantly lower when filling with silicone oil, compared with other agents. No trial reported the quality of life related to postoperative position.
  
  
  CONCLUSIONS
  Based on the available studies, the authors conclude that there is no significant difference in the risk of poor outcomes between pars plana vitrectomy with silicone oil and that with other vitreous tamponades with different surgical histories.
authors.affiliation: *Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China; and †Director of Statistics Medical Research & Biometrics Center, National Center for Cardiovascular Disease, Fuwai Hospital, Beijing, China.
authors.forename: XiaoXiao
authors.initials: X
authors.lastname: Feng
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.forename: Qishan
authors.initials: Q
authors.lastname: Zheng
authors.forename: XiaoBin G
authors.initials: XG
authors.lastname: Qian
authors.forename: WanWen
authors.initials: W
authors.lastname: Shao
authors.forename: YuJie
authors.initials: Y
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Lu
authors.initials: L
authors.lastname: Yin
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: QianYing
authors.initials: Q
authors.lastname: Gao
mesh_terms: D058450:Endotamponade / Q000009:adverse effects*; D014943:Global Health; D006801:Humans; D015994:Incidence; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D012086:Reoperation / Q000706:statistics & numerical data; D012163:Retinal Detachment / Q000503:physiopathology / Q000601:surgery*; D012827:Silicone Oils / Q000008:administration & dosage*; D014792:Visual Acuity; D014821:Vitrectomy / Q000009:adverse effects*
chemical_list: D012827:Silicone Oils