title: Protein transport in growing and steady-state cilia.
abstract: Cilia and eukaryotic flagella are threadlike cell extensions with motile and sensory functions. Their assembly requires intraflagellar transport (IFT), a bidirectional motor-driven transport of protein carriers along the axonemal microtubules. IFT moves ample amounts of structural proteins including tubulin into growing cilia likely explaining its critical role for assembly. IFT continues in non-growing cilia contributing to a variety of processes ranging from axonemal maintenance and the export of non-ciliary proteins to cell locomotion and ciliary signaling. Here, we discuss recent data on cues regulating the type, amount and timing of cargo transported by IFT. A regulation of IFT-cargo interactions is critical to establish, maintain and adjust ciliary length, protein composition and function.
authors.affiliation: Department of Cellular Biology, University of Georgia, Athens, Georgia.
authors.forename: Karl F
authors.initials: KF
authors.lastname: Lechtreck
authors.affiliation: Department of Cellular Biology, University of Georgia, Athens, Georgia.
authors.forename: Julie C
authors.initials: JC
authors.lastname: Van De Weghe
authors.affiliation: Department of Cellular Biology, University of Georgia, Athens, Georgia.
authors.forename: James Aaron
authors.initials: JA
authors.lastname: Harris
authors.affiliation: Department of Cellular Biology, University of Georgia, Athens, Georgia.
authors.forename: Peiwei
authors.initials: P
authors.lastname: Liu
mesh_terms: D000818:Animals; D002923:Cilia / Q000378:metabolism* / Q000502:physiology*; D005407:Flagella / Q000378:metabolism / Q000502:physiology; D006801:Humans; D021381:Protein Transport / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D014404:Tubulin / Q000378:metabolism
chemical_list: D011506:Proteins; D014404:Tubulin
keywords: diffusion; flagella; intraflagellar transport; microtubule