title: Papers of note inNature542(7641).
abstract: This week's articles highlight a tRNA synthetase in mTORC1 signaling in fat cell metabolism and aging, the vulnerability of cancer cells to drugs that target proteostasis, and a mechanism by which stressed neurons expel protein aggregates and dysfunctional organelles.
authors.affiliation: Science Signaling, AAAS, Washington, DC 20005, USA.
authors.forename: Annalisa M
authors.initials: AM
authors.lastname: VanHook
mesh_terms: D050154:Adiposity; D000818:Animals; D003593:Cytoplasm; D000076222:Mechanistic Target of Rapamycin Complex 1; D051379:Mice; D009765:Obesity; D015398:Signal Transduction
chemical_list: D000076222:Mechanistic Target of Rapamycin Complex 1