title: Technical approaches to induce selective cell death of pluripotent stem cells.
abstract: Despite the recent promising results of clinical trials using human pluripotent stem cell (hPSC)-based cell therapies for age-related macular degeneration (AMD), the risk of teratoma formation resulting from residual undifferentiated hPSCs remains a serious and critical hurdle for broader clinical implementation. To mitigate the tumorigenic risk of hPSC-based cell therapy, a variety of approaches have been examined to ablate the undifferentiated hPSCs based on the unique molecular properties of hPSCs. In the present review, we offer a brief overview of recent attempts at selective elimination of undifferentiated hPSCs to decrease the risk of teratoma formation in hPSC-based cell therapy.
authors.affiliation: Dept. of Life Sciences, College of Natural Sciences, Sogang University, #1 Sinsu-dong, Mapo-gu, Seoul,, 121-742, Republic of Korea.
authors.forename: Ho-Chang
authors.initials: HC
authors.lastname: Jeong
authors.affiliation: Dept. of Life Sciences, College of Natural Sciences, Sogang University, #1 Sinsu-dong, Mapo-gu, Seoul,, 121-742, Republic of Korea.
authors.forename: Seung-Ju
authors.initials: SJ
authors.lastname: Cho
authors.affiliation: Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon,, 305-806, Republic of Korea.
authors.forename: Mi-Ok
authors.initials: MO
authors.lastname: Lee
authors.affiliation: Dept. of Life Sciences, College of Natural Sciences, Sogang University, #1 Sinsu-dong, Mapo-gu, Seoul,, 121-742, Republic of Korea. hjcha@sogang.ac.kr.
authors.forename: Hyuk-Jin
authors.initials: HJ
authors.lastname: Cha
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D041722:Genes, Transgenic, Suicide; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D054852:Small Molecule Libraries / Q000494:pharmacology; D033581:Stem Cell Transplantation / Q000379:methods*
chemical_list: D035683:MicroRNAs; D054852:Small Molecule Libraries
keywords: Apoptosis; Human pluripotent stem cells; Safe stem cell therapy; Selective cell death; Teratoma