title: Commanding CNS Invasion: GM-CSF.
abstract: Granulocyte-macrophage colony-stimulating factor (GM-CSF or Csf-2) is a pro-inflammatory mediator implicated in the pathogenesis of various autoimmune diseases. In this issue of Immunity, Spath et al. (2017) show that the dysregulated production of GM-CSF rather than IL-17 induces spontaneous immunopathology in a mouse model of CNS inflammation.
authors.affiliation: Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Cleveland Clinic Lerner College of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
authors.forename: Lillian
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA. Electronic address: lix@ccf.org.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D007249:Inflammation; D020381:Interleukin-17
chemical_list: D020381:Interleukin-17; D016178:Granulocyte-Macrophage Colony-Stimulating Factor