title: IgG4-Related Disease Causing Rapid Evolution of a Severe Aortic Valvular Stenosis.
abstract: Immunoglobulin G4-related systemic disease (IgG4-RSD) is a recognized emerging entity characterized by chronic fibroinflammation that can affect every organ but rarely affects the cardiovascular system. We report a rare case of IgG4-RSD involving an aortic valve that resulted in rapid progression of an aortic valvular stenosis and was successfully treated by aortic valve replacement and corticosteroids.
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, University Hospital of Liège, Liège, Belgium.
authors.forename: Samuel
authors.initials: S
authors.lastname: Bruls
authors.affiliation: Surgical Research Center, GIGA-R, University of Liège, Liège, Belgium.
authors.forename: Audrey
authors.initials: A
authors.lastname: Courtois
authors.affiliation: Department of Pathology, University Hospital of Liège, Liège, Belgium.
authors.forename: Philippe
authors.initials: P
authors.lastname: Delvenne
authors.affiliation: Department of Nuclear Medicine, University Hospital of Liège, Liège, Belgium.
authors.forename: Roland
authors.initials: R
authors.lastname: Hustinx
authors.affiliation: Department of Infectious Diseases, University Hospital of Liège, Liège, Belgium.
authors.forename: Michel
authors.initials: M
authors.lastname: Moutschen
authors.affiliation: Department of Clinical Pathology, CHUV, Lausanne, Switzerland.
authors.forename: Laurence
authors.initials: L
authors.lastname: De Leval
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, University Hospital of Liège, Liège, Belgium.
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Defraigne
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, University Hospital of Liège, Liège, Belgium; Surgical Research Center, GIGA-R, University of Liège, Liège, Belgium. Electronic address: nsaka@chu.ulg.ac.be.
authors.forename: Natzi
authors.initials: N
authors.lastname: Sakalihasan
mesh_terms: D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000209:etiology / Q000601:surgery*; D005355:Fibrosis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D010950:Plasma Cells / Q000276:immunology
chemical_list: D007074:Immunoglobulin G