title: Social cognition according to cognitive impairment in different clinical phenotypes of multiple sclerosis.
abstract: The objective of this study is to evaluate the relationship between social cognition (SC) and cognitive impairment in persons with multiple sclerosis (PwMS). A prospective study was conducted in 60 PwMS, 30 with relapsing-remitting MS (RRMS), 15 with secondary progressive MS (SPMS) and 15 with primary progressive MS (PPMS), and in healthy subjects (HS). All subjects were assessed by the Bordeaux Social Cognition Evaluation Protocol (PECS-B) (facial emotion recognition, theory of mind, emotional awareness and cognitive and affective alexithymia), by a large neuropsychological battery and by questionnaires (depression and anxiety). 43.3% of PwMS were impaired for at least one SC test. The proportion of PwMS with at least two impaired SC tests was similar in all three phenotypes (20%). Mean scores differed significantly between PwMS and HS only for the Reading the Mind in the Eyes Test, a test of Theory of Mind (ToM). ANOVA analyses showed an effect of phenotype on emotional awareness scores with lower scores in PPMS as compared to RRMS. ToM performance was significantly correlated (r2= 0.56) with executive functions, working memory and episodic memory scores. SC impairment was found in all phenotypes and was more prominent in cognitively impaired MS patients. Executive functions, and working and episodic memory performance accounts for approximately 50% of ToM performance. Emotional awareness is more impaired in progressive MS.
authors.affiliation: CHU de Bordeaux, INSERM-CHU CIC-P 1401 & Service de Neurologie, 33076, Bordeaux, France.
authors.forename: Cecile
authors.initials: C
authors.lastname: Dulau
authors.affiliation: CHU de Bordeaux, INSERM-CHU CIC-P 1401 & Service de Neurologie, 33076, Bordeaux, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Deloire
authors.affiliation: Université de Bordeaux, Bordeaux, France.|Laboratoire de Psychologie (santé et qualité de vie), EA4139, Bordeaux, France.
authors.forename: Helene
authors.initials: H
authors.lastname: Diaz
authors.affiliation: CHU de Bordeaux, INSERM-CHU CIC-P 1401 & Service de Neurologie, 33076, Bordeaux, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Saubusse
authors.affiliation: CHU de Bordeaux, INSERM-CHU CIC-P 1401 & Service de Neurologie, 33076, Bordeaux, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Charre-Morin
authors.affiliation: Université de Bordeaux, Bordeaux, France.|Laboratoire de Psychologie (santé et qualité de vie), EA4139, Bordeaux, France.
authors.forename: Antoinette
authors.initials: A
authors.lastname: Prouteau
authors.affiliation: CHU de Bordeaux, INSERM-CHU CIC-P 1401 & Service de Neurologie, 33076, Bordeaux, France. bruno.brochet@chu-bordeaux.fr.|Université de Bordeaux, Bordeaux, France. bruno.brochet@chu-bordeaux.fr.|INSERM U.1215, Neurocentre Magendie, Bordeaux, France. bruno.brochet@chu-bordeaux.fr.
authors.forename: Bruno
authors.initials: B
authors.lastname: Brochet
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000209:etiology*; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000523:psychology*; D009483:Neuropsychological Tests; D011581:Psychological Tests; D021641:Recognition, Psychology; D012189:Retrospective Studies; D012919:Social Behavior; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D056345:Theory of Mind
keywords: Cognition; Executive function; Multiple sclerosis; Social cognition; Theory of mind