title: Systematic screening for CYP3A4 genetic polymorphisms in a Han Chinese population.
abstract: OBJECTIVE
  To systematically investigate the genetic polymorphisms of the CYP3A4 gene in a Han Chinese population.
  
  
  METHODS
  The promoter and exons of CYP3A4 gene in 1114 unrelated, healthy Han Chinese subjects were amplified and genotyped by direct sequencing.
  
  
  RESULTS
  In total, five previously reported alleles (*1G, *4, *5, *18B and *23) were detected, of which one allele (*23) was reported for the first time in Han Chinese population. Additionally, seven novel exonic variants were also identified and designated as new alleles CYP3A4*28-*34.
  
  
  CONCLUSIONS
  This study provides the most comprehensive data of CYP3A4 polymorphisms in Han Chinese population and detects the largest number of novel CYP3A4 alleles in one ethnic group.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
authors.forename: Guo-Xin
authors.initials: GX
authors.lastname: Hu
authors.affiliation: The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, P.R. China.
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Dai
authors.affiliation: Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
authors.forename: Xiang-Xin
authors.initials: XX
authors.lastname: Huang
authors.affiliation: The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, P.R. China.
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Zhou
authors.affiliation: Department of Pharmacy, Traditional Chinese Medical Hospital of Wenling, Wenling, Zhejiang 317500, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Cardiology, Beijing Hospital, Beijing 100730, P.R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.affiliation: The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, P.R. China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Cai
mesh_terms: D044466:Asian People / Q000235:genetics*; D051544:Cytochrome P-450 CYP3A / Q000235:genetics*; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011159:Population Surveillance / Q000379:methods; D055815:Young Adult
chemical_list: D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human
keywords: CYP3A4; Han Chinese population; genetic polymorphism; novel allelic variants