title: Dexmedetomidine to control signs associated with lisdexamfetamine dimesylate toxidrome in a cat.
abstract: A 5-month-old intact female domestic shorthaired cat had mydriasis, agitation, and increased locomotion after ingestion of lisdexamfetamine, 10.3 mg/kg body weight (BW). Despite treatment with IV fluids, IV acepromazine, oral cyproheptadine and intravenous lipid emulsion the patient's clinical signs worsened. Dexmedetomidine administered at 2 μg/kg BW and continued at 0.5 μg/kg BW per hour rapidly controlled the patient's signs. An episode of vomiting and hematuria developed. Follow-up 5 days after discharge revealed that the cat appeared normal.
authors.affiliation: Allegheny Veterinary Emergency Trauma & Specialty, 4224 Northern Pike, Monroeville, Pennsylvania, 15146, USA (Norkus, Keir); ASPCA Animal Poison Control Center, 1717 S Philo Road, Suite 36 Urbana, Illinois 61802, USA (Means).
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Norkus
authors.affiliation: Allegheny Veterinary Emergency Trauma & Specialty, 4224 Northern Pike, Monroeville, Pennsylvania, 15146, USA (Norkus, Keir); ASPCA Animal Poison Control Center, 1717 S Philo Road, Suite 36 Urbana, Illinois 61802, USA (Means).
authors.forename: Iain
authors.initials: I
authors.lastname: Keir
authors.affiliation: Allegheny Veterinary Emergency Trauma & Specialty, 4224 Northern Pike, Monroeville, Pennsylvania, 15146, USA (Norkus, Keir); ASPCA Animal Poison Control Center, 1717 S Philo Road, Suite 36 Urbana, Illinois 61802, USA (Means).
authors.forename: Charlotte
authors.initials: C
authors.lastname: Means
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000627:therapeutic use*; D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced* / Q000188:drug therapy; D002415:Cats; D020927:Dexmedetomidine / Q000627:therapeutic use*; D005260:Female; D000069478:Lisdexamfetamine Dimesylate / Q000506:poisoning*; D020230:Serotonin Syndrome / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D020927:Dexmedetomidine; D000069478:Lisdexamfetamine Dimesylate