title: Lipid Peroxidation: Kinetics, Mechanisms, and Products.
abstract: Recent advances in our understanding of lipid peroxidation, a degenerative process that is believed to play a key role in the pathogenesis of many diseases, are highlighted. In particular, the factors that control the kinetics and regio-/stereochemical outcomes of the autoxidation of both polyunsaturated fatty acids and sterols and the subsequent decomposition of the hydroperoxide products to cytotoxic derivatives are discussed. These advances promise to help clarify the role of lipid peroxidation in cell death and human disease.
authors.affiliation: Department of Chemistry and Biomolecular Sciences, University of Ottawa , Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Zosia A M
authors.identifier: 0000-0001-6577-8559
authors.initials: ZA
authors.lastname: Zielinski
authors.affiliation: Department of Chemistry and Biomolecular Sciences, University of Ottawa , Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Derek A
authors.identifier: 0000-0002-7305-745X
authors.initials: DA
authors.lastname: Pratt
mesh_terms: D006838:Hydrocarbons / Q000737:chemistry; D007700:Kinetics; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction
chemical_list: D006838:Hydrocarbons