title: [A retrospective cohort study on survival status of AIDS patients among 15 or above-year-olds in Henan province, from 2008 to 2015].
abstract: Objective:To explore the survival status and affecting factors among patients diagnosed as AIDS, in Henan province.Methods:Database of AIDS patients were downloaded from the China information system for disease prevention and control-AIDS with a retrospective study conducted. Inclusion criteria on patients would involve those diagnosed between 2008 and 2015, aged 15 years or above.Results:A total number of 25 525 HIV/AIDS patients were enrolled in this study. During the follow-up period, the overall mortality among all the patients was 24.9%. Mortality of those having received the highly active antiretroviral treatment (HAART) was 14.4%. Proportion for the treatment coverage increased gradually, from 72.1% in 2008 to 92.8% in 2015. The overall mortality rate dropped from 21.2% to 4.1% and the mortality of those having received HAART patients dropped from 9.2% to 2.6%. Results from the multiple factors analysis showed that factors as: CD(4)(+) T cell count (CD(4)) <50 cell/μl when the AIDS diagnosis was made (adjustedHR=2.45) were related to higher risk on mortality among HIV/AIDS patients. Patients having received HAART (adjustedHR=0.13) had lower risks on mortality. Among patients having received treatment, results from the multiple factors analysis showed that factor as TMP-SMZ dosage being administered (adjustedHR=0.76) were related to low mortality risk. As for CD(4) counts of the patients, the adjustedHRs were 1.26 in 50-cells/μl group and 1.97 in the <50 cells/μl group, respectively when the diagnosis was made. Both groups had high risk on mortality patients with lower baseline CD(4) counts (adjustedHRwere 1.44, 1.84 in 50-cells/μl and <50 cells/μl groups, respectively) seemed to have higher risk on mortality.Conclusions:Antiretroviral therapy appeared an important factor that affecting the survival of HIV/AIDS patients. CD(4) count test, early identifying and treating the AIDS patients together with providing TMP-SMZ prevention and treatment programs, were important approaches in extending the survival time so as to reduce the death rates from AIDS related illnesses.
authors.affiliation: Institute for AIDS/STD Prevention and Cure, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Yang
authors.forename: N
authors.initials: N
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Liang
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: P Y
authors.initials: PY
authors.lastname: Fan
authors.forename: D Y
authors.initials: DY
authors.lastname: Sun
authors.forename: Q
authors.initials: Q
authors.lastname: Zhu
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000208:ethnology / Q000401:mortality*; D000328:Adult; D000367:Age Factors; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002681:China / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000208:ethnology / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012306:Risk; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D044966:Anti-Retroviral Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: HIV/AIDS; Retrospective cohort; Survival status