title: Ambiguities in the Guidelines for the Management of Arterial Hypertension: Indian Perspective with a Call for Global Harmonization.
abstract: Many medical professional societies have formulated guidelines to treat hypertension, but there existed differences with respect to diagnosis, blood pressure (BP) targets, pharmacotherapy of hypertension, and grades of evidence. A MEDLINE search for hypertension guidelines was performed to compare Indian guidelines for hypertension (IGH) with these guidelines. A majority of the guidelines had consensus on the cutoff value (140/90 mmHg, recorded twice) to diagnose hypertension. The Joint National Committee 8 (JNC 8), IGH, Japanese Society of hypertension (JSH), Canadian Hypertension Education Program (CHEP), and American Society of Hypertension/International Society of Hypertension (ASH/ISH) guidelines provide a higher BP target for the elderly hypertensive populations, while the National Institute for Health and Care Excellence (NICE) and European Society of Hypertension (ESH) guidelines provided a lower BP target for the elderly patients. However, a meta-analysis showed benefits of having a systolic BP target of <130 mmHg for all patients. Treatment of hypertension according to JNC 8, NICE, and ASH/ISH guidelines varies among the black and the non-black population which recommended thiazide or calcium channel blockers for the black population. There is no special mention of pharmacotherapy or BP targets for the South Asian population in various guidelines including IGH despite evidence of higher risk of hypertension-associated complications in this population. It is suggested that all the available guidelines should be harmonized with highest level of evidence available to minimize ambiguities associated with management of hypertension.
authors.affiliation: Department of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, Shaheed Bhagat Singh Marg, New Delhi, 110001, India. harmeetrehan@hotmail.com.
authors.forename: Harmeet Singh
authors.initials: HS
authors.lastname: Rehan
authors.affiliation: Department of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.
authors.forename: Abhinav
authors.initials: A
authors.lastname: Grover
authors.affiliation: Centre for Integrated Health Care Research, School of Medicine, Pharmacy and Health, Wolfson Building, Queen's Campus, Stockton (Durham University), Stockton, UK.
authors.forename: A P S
authors.initials: AP
authors.lastname: Hungin
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D044466:Asian People; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D017408:Guidelines as Topic; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007194:India; D012955:Societies, Medical
chemical_list: D000959:Antihypertensive Agents
keywords: Blood pressure; Guidelines; Hypertension