title: [Prostadoz opportunity for prostate cancer prevention?]
abstract: Prevention of prostate cancer (PCa) is a vital problem dictated by the obvious benefit of prevention compared to the complexity of treatment. To date, a tremendous amount of research both in vitro, and in vivo assessment of different prophylactic measures has been published. They included consumption of protein, carbohydrate, fat, fiber, vegetable extracts and other solid products, and combinations thereof in the diet, vitamins, minerals, and biologically active substances, medicaments. The optimal preventive agent has not been found, and that prompted us to conduct our own research of dietary supplement ProstaDoz. The study was performed on a group of 58 patients with elevated prostate-specific antigen and the results of the histological study confirming the absence of prostate cancer and the presence of a high degree PIN. After 6 month course of ProstaDoz histological analysis of repeated biopsy samples revealed a significantly lower incidence of prostate cancer and atypical small acinar proliferation in the group receiving ProstaDoz (10.4%) compared to control group (20,7%; p <0,024), and in some cases even regression of PIN (32%) in the study group (p = 0.5). Also, there was a significant reduction in prostate-specific antigen after receiving ProstaDoz. These data show the potential effectiveness of ProstaDoz use as a means of PCa chemoprevention.
authors.affiliation: Clinic of Urology, Sechenov First Moscow State Medical University Research Institute of Uronephrology and Human Reproductive Health.
authors.forename: Yu G
authors.initials: YG
authors.lastname: Alyaev
authors.affiliation: Clinic of Urology, Sechenov First Moscow State Medical University Research Institute of Uronephrology and Human Reproductive Health.
authors.forename: L M
authors.initials: LM
authors.lastname: Rapoport
authors.affiliation: Clinic of Urology, Sechenov First Moscow State Medical University Research Institute of Uronephrology and Human Reproductive Health.
authors.forename: D G
authors.initials: DG
authors.lastname: Tsarichenko
authors.affiliation: Clinic of Urology, Sechenov First Moscow State Medical University Research Institute of Uronephrology and Human Reproductive Health.
authors.forename: T M
authors.initials: TM
authors.lastname: Ganzha
authors.affiliation: Clinic of Urology, Sechenov First Moscow State Medical University Research Institute of Uronephrology and Human Reproductive Health.
authors.forename: G E
authors.initials: GE
authors.lastname: Krupinov
mesh_terms: D019587:Dietary Supplements; D006801:Humans; D008297:Male; D008903:Minerals; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000517:prevention & control; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D008903:Minerals; D014815:Vitamins; D017430:Prostate-Specific Antigen
keywords: ProstaDoz; prostate cancer prevention