title: Spray-drying process preserves the protective capacity of a breast milk-derived Bifidobacterium lactis strain on acute and chronic colitis in mice.
abstract: Gut microbiota dysbiosis plays a central role in the development and perpetuation of chronic inflammation in inflammatory bowel disease (IBD) and therefore is key target for interventions with high quality and functional probiotics. The local production of stable probiotic formulations at limited cost is considered an advantage as it reduces transportation cost and time, thereby increasing the effective period at the consumer side. In the present study, we compared the anti-inflammatory capacities of the Bifidobacterium animalis subsp. lactis (B. lactis) INL1, a probiotic strain isolated in Argentina from human breast milk, with the commercial strain B. animalis subsp. lactis BB12. The impact of spray-drying, a low-cost alternative of bacterial dehydration, on the functionality of both bifidobacteria was also investigated. We showed for both bacteria that the spray-drying process did not impact on bacterial survival nor on their protective capacities against acute and chronic colitis in mice, opening future perspectives for the use of strain INL1 in populations with IBD.
authors.affiliation: Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.|Instituto de Lactología Industrial (INLAIN, UNL-CONICET), Facultad de Ingeniería Química, Universidad Nacional del Litoral, Santiago del Estero 2829, Santa Fe (3000), Argentina.
authors.forename: Patricia
authors.initials: P
authors.lastname: Burns
authors.affiliation: Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Alard
authors.affiliation: Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
authors.forename: Jiri
authors.initials: J
authors.lastname: Hrdỳ
authors.affiliation: Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
authors.forename: Denise
authors.initials: D
authors.lastname: Boutillier
authors.affiliation: INTA EEA Rafaela, Ruta 34 km 227, Santa Fe, Argentina.
authors.forename: Roxana
authors.initials: R
authors.lastname: Páez
authors.affiliation: Instituto de Lactología Industrial (INLAIN, UNL-CONICET), Facultad de Ingeniería Química, Universidad Nacional del Litoral, Santiago del Estero 2829, Santa Fe (3000), Argentina.
authors.forename: Jorge
authors.initials: J
authors.lastname: Reinheimer
authors.affiliation: Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Pot
authors.affiliation: Instituto de Lactología Industrial (INLAIN, UNL-CONICET), Facultad de Ingeniería Química, Universidad Nacional del Litoral, Santiago del Estero 2829, Santa Fe (3000), Argentina.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Vinderola
authors.affiliation: Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Grangette
mesh_terms: D000818:Animals; D001118:Argentina; D001431:Bacteriological Techniques / Q000379:methods; D000069982:Bifidobacterium animalis / Q000302:isolation & purification* / Q000502:physiology; D003092:Colitis / Q000517:prevention & control*; D003890:Desiccation / Q000379:methods*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D050296:Microbial Viability; D008895:Milk, Human / Q000382:microbiology*; D019936:Probiotics / Q000008:administration & dosage* / Q000302:isolation & purification*; D013678:Technology, Pharmaceutical / Q000379:methods*