title: The Possible Crosstalk of MOB2 With NDR1/2 Kinases in Cell Cycle and DNA Damage Signaling.
abstract: This article is the authors' opinion of the roles of the signal transducer Mps one binder 2 (MOB2) in the control of cell cycle progression and the DNA Damage Response (DDR). We recently found that endogenous MOB2 is required to prevent the accumulation of endogenous DNA damage in order to prevent the undesired, and possibly detrimental, activation of cell cycle checkpoints. In this regard, it is noteworthy that MOB2 has been linked biochemically to the regulation of the NDR1/2 (aka STK38/STK38L) protein kinases, which themselves have functions at different steps of the cell cycle. Therefore, we are speculating in this article about the possible connections of MOB2 with NDR1/2 kinases in cell cycle and DDR Signaling.
authors.affiliation: Tumour Suppressor Signaling Networks Laboratory, UCL Cancer Institute, University College London, UK.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Gundogdu
authors.affiliation: Tumour Suppressor Signaling Networks Laboratory, UCL Cancer Institute, University College London, UK.
authors.forename: Alexander
authors.initials: A
authors.lastname: Hergovich
keywords: Cell cycle progression; DNA damage signaling; Nuclear Dbf2-related kinase; Phosphorylation; Protein-protein interaction; Serine/threonine protein kinase 38; mps one binder