title: CNPY2 promoted the proliferation of renal cell carcinoma cells and increased the expression of TP53.
abstract: Renal cell carcinoma (RCC) is the most common type of kidney cancer. However, the mechanisms underlying the progression of the disease are not well understood. The data in this report suggest that canopy FGF signaling regulator 2 (CNPY2) is a promoter of RCC progression. We found that CNPY2 significantly promoted growth of RCC cells and upregulated TP53 gene expression. Although TP53 is widely known as a tumor suppressor, in RCC TP53 promoted tumor cell growth. A typical p53 target gene, CDKN1A, was upregulated by both p53 and CNPY2 in RCC cells, suggesting that CNPY2 increased the expression level of TP53. Consistent with these results, CNPY2 and TP53 expression levels were positively correlated in RCC patients. These findings suggested that CNPY2 promoted cancer cell growth in RCC through regulating TP53 gene expression.
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kajii-cho, 465, Kyoto City, Kyoto 602-8566, Japan.
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Taniguchi
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kajii-cho, 465, Kyoto City, Kyoto 602-8566, Japan. Electronic address: itosaya@koto.kpu-m.ac.jp.
authors.forename: Saya
authors.initials: S
authors.lastname: Ito
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kajii-cho, 465, Kyoto City, Kyoto 602-8566, Japan; Department of Urology, Uji Takeda Hospital, 36-26 Uji-satojiri, Uji, Kyoto, 611-0021, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ueda
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kajii-cho, 465, Kyoto City, Kyoto 602-8566, Japan.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Morioka
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kajii-cho, 465, Kyoto City, Kyoto 602-8566, Japan.
authors.forename: Naruhiro
authors.initials: N
authors.lastname: Kayukawa
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kajii-cho, 465, Kyoto City, Kyoto 602-8566, Japan.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Ueno
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kajii-cho, 465, Kyoto City, Kyoto 602-8566, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Nakagawa
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kajii-cho, 465, Kyoto City, Kyoto 602-8566, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Fujihara
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kajii-cho, 465, Kyoto City, Kyoto 602-8566, Japan.
authors.forename: So
authors.initials: S
authors.lastname: Ushijima
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kajii-cho, 465, Kyoto City, Kyoto 602-8566, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Kanazawa
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kajii-cho, 465, Kyoto City, Kyoto 602-8566, Japan.
authors.forename: Fumiya
authors.initials: F
authors.lastname: Hongo
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kajii-cho, 465, Kyoto City, Kyoto 602-8566, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Ukimura
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D007680:Kidney Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C502333:CNPY2 protein, human; D016159:Tumor Suppressor Protein p53
keywords: CNPY2; Renal cell carcinoma; p53