title: Mechanisms Underlying Drug Delivery to Peripheral Arteries.
abstract: Delivery of drugs onto arterial targets via endovascular devices commands several principles: dissolution, diffusion, convection, drug binding, barriers to absorption, and interaction between the drug, delivery vehicle, and accepting arterial wall. The understanding of drug delivery in the coronary vasculature is vast; there is ongoing work needed in the peripheral arteries. There are differences that account for some failures of application of coronary technology into the peripheral vascular space. Breakthroughs in peripheral vascular interventional techniques building on current technologies require investigators willing to acknowledge the similarities and differences between these different vascular territories, while developing technologies adapted for peripheral arteries.
authors.affiliation: Division of Cardiovascular Medicine, Department of Interventional Cardiology, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, 11000 Euclid Avenue, Cleveland, OH 44106, USA; Department of Medicine, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: CBSET Inc, 500 Shire Way, Lexington, MA 02421, USA.
authors.forename: Rami
authors.initials: R
authors.lastname: Tzafriri
authors.affiliation: Division of Cardiovascular Medicine, Department of Interventional Cardiology, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, 11000 Euclid Avenue, Cleveland, OH 44106, USA; Department of Medicine, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA.
authors.forename: Sandeep M
authors.initials: SM
authors.lastname: Patel
authors.affiliation: Endovascular Services, Division of Cardiology, Department of Medicine, Center for Interventional Vascular Therapy, Columbia University Medical Center/NY Presbyterian Hospital, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, New York, NY 10032, USA. Electronic address: sap2196@cumc.columbia.edu.
authors.forename: Sahil A
authors.initials: SA
authors.lastname: Parikh
mesh_terms: D001158:Arteries; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D054855:Drug-Eluting Stents; D006801:Humans; D058729:Peripheral Arterial Disease / Q000628:therapy*
chemical_list: D002317:Cardiovascular Agents
keywords: Drug delivery; Drug-coated balloons; Drug-eluting stents; Peripheral arterial disease