title: Effects of statins on the development of sepsis and organ dysfunction in hospitalized older patients in China.
abstract: This study aimed to evaluate the protective role of statins on the development of sepsis and infection-related organ dysfunction and mortality in a hospitalized older Chinese population with bacterial infections. In this retrospective cohort study, 257 older patients with bacterial infection were divided into two groups: a statin group, those who had received statin therapy for ≥1 month before admission and continued receiving statin during hospitalization; and a non-statin group, those who had never received statin or used statin for <1 month prior to admission. A multivariate logistic regression analysis was performed to identify risk and protective factors for severe sepsis. A significantly lower incidence of organ dysfunction was found in the statin group, as compared with the non-statin group (13.3% vs 31.1%, respectively; p=0.002), corresponding to adjusted rates ratio of 0.32 (95% confidence interval [CI], 0.13-0.75; p=0.009). No significant difference was found between statin and non-statin groups in 30-day sepsis-related mortality (4.4% vs 10.2%, respectively; p=0.109), incidence of intensive care unit admission (13.3% vs 16.8%, respectively; p=0.469), or length of hospital stay (20.5 vs 25.9 days, respectively; p=0.61). Statins significantly reduced the development of sepsis and infection-related organ dysfunction in hospitalized older Chinese patients but did not reduce 30-day mortality, ICU admission incidence, or length of hospital stay.
authors.affiliation: Zhejiang University, First Affiliated Hospital School of Medicine, Department of Geriatrics, Hangzhou, China.
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Gui
authors.affiliation: Zhejiang University, First Affiliated Hospital School of Medicine, Department of Geriatrics, Hangzhou, China. Electronic address: yangyunmei2008@sina.com.
authors.forename: Yunmei
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Zhejiang University, First Affiliated Hospital School of Medicine, Department of Geriatrics, Hangzhou, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000150:complications* / Q000401:mortality; D002681:China; D015331:Cohort Studies; D016638:Critical Illness; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D007902:Length of Stay; D008297:Male; D009102:Multiple Organ Failure / Q000401:mortality / Q000517:prevention & control*; D012044:Regression Analysis; D012189:Retrospective Studies; D018805:Sepsis / Q000401:mortality / Q000517:prevention & control*; D012720:Severity of Illness Index
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Mortality; Older adults; Organ dysfunction; Sepsis; Statins