title: Structural characterization and dissolution profile of mycophenolic acid cocrystals.
abstract: Three novel cocrystals of mycophenolic acid (MPA) with isonicotinamide (MPA-ISO), minoxidil (MPA-MIN) and 2,2'-dipyridylamine (MPA-DPA) as coformers have been prepared successfully by both slow evaporation and liquid-assisted grinding. The structures of these cocrystals show that all the three coformers form hydrogen bonds with the carboxylic acid group of MPA. The cocrystal MPA-ISO possesses remarkably improved solubility and dissolution rate, while two other cocrystals exhibit the opposite characteristics. The solids in the slurry with pH6.8 phosphate buffer and cocrystals remain as the incipient cocrystal after 24h. However, evidence of slight polymerization was shown in the slurry of pH6.8 phosphate buffer with MPA and MPA-ISO cocrystal.
authors.affiliation: School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, PR China.
authors.forename: Qing-Zhu
authors.initials: QZ
authors.lastname: Zeng
authors.affiliation: School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Ouyang
authors.affiliation: School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510640, PR China. Electronic address: bishuoz@scut.edu.cn.
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.affiliation: School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510640, PR China. Electronic address: lzhangce@scut.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
mesh_terms: D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D065546:Drug Liberation; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D008914:Minoxidil / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009173:Mycophenolic Acid / Q000737:chemistry*; D009536:Niacinamide / Q000737:chemistry*; D033362:Powder Diffraction; D011208:Powders; D012995:Solubility; D014961:X-Ray Diffraction
chemical_list: D011208:Powders; D009536:Niacinamide; C027681:isonicotinamide; D015082:2,2'-Dipyridyl; D008914:Minoxidil; D009173:Mycophenolic Acid; C048062:2,2'-dipyridylamine
keywords: Cocrystal; Dissolution study; Mycophenolic acid; Structure