title: [Effects of low-frequency pulsed wave ultrasound on the shear properties of the interface of vancomycin-loaded acrylic bone cement-stem].
abstract: Objective:To investigate the effects of low-frequency pulsed wave ultrasound on the shear properties of interface of the vancomycin -loaded acrylic bone cement-stem.Methods:The interfaces of 1% vancomycin-loaded acrylic bone cement-stem specimences were successfully manufactured and randomly divided into three groups: the control group, 450 mW/cm(2) ultrasound group and 1 200 mW/cm(2) ultrasound group, each group consisted of eight samples.Two ultrasound groups were exposed to a local ultrasonic field for 7 d, then immersed in PBS for 23 d, and the control groups were immersed in PBS for 30 d. After curing in air for 24 h, the shear strength of the stem-cement interface was determined by push-out test.The specimens were then photographed using SEM and analysed using Image-Pro Plus 6.0 to determine the porosity at the stem-cement interface.Results:The mean shear strength of stem-cement interface additionally decreased by 9% (P>0.05) and 17% (P<0.05) in 450 mW/cm(2) ultrasound group and 1 200 mW/cm(2) group respectively comparing with the control group, but no significant difference was found between the two ultrasound groups.The porosity at the stem-cement interface additionally increased by 44% (P>0.05) and 110% (P<0.05) in 450 mW/cm(2) ultrasound group and 1 200 mW/cm(2) group respectively comparing with the control group, furthermore.The porosity in 1 200 mW/cm(2) ultrasound group increased by 46% (P<0.05) comparing with the 450 mW/cm(2) group. There are much more fluid penetration along the stem-cement interface in ultrasound group .Conclusion:Low-frequency pulsed wave ultrasound signifiantly enhanced porosity and fluid penetration interface, and reduced the interface shear strength and initial stability.
authors.affiliation: Department of Orthopaedics, the Third People's Hospital of Hangzhou, Hangzhou 310009, China.
authors.forename: Q H
authors.initials: QH
authors.lastname: Zhao
authors.forename: F B
authors.initials: FB
authors.lastname: Zhu
authors.forename: X Z
authors.initials: XZ
authors.lastname: Cai
authors.forename: S G
authors.initials: SG
authors.lastname: Yan
authors.forename: R X
authors.initials: RX
authors.lastname: He
mesh_terms: D001843:Bone Cements; D019904:Polymethyl Methacrylate; D016062:Porosity; D014463:Ultrasonography; D014640:Vancomycin
chemical_list: D001843:Bone Cements; D014640:Vancomycin; D019904:Polymethyl Methacrylate
keywords: Prostheses and implants; Stress, mechanical; Ultrasonic therapy; Vancomycin