title: [A 20-year-old woman with ulcerative colitis and acute liver failure].
abstract: A 20-year-old woman presented with acute exacerbation of ulcerative colitis. After treatment with infliximab, she developed a fulminant liver failure. Under supportive therapy and steroid medication, recovery of symptoms and transaminases occurred. A few case reports about hepatic side effects of anti-TNF-α antibodies in patients with inflammatory bowel disease have been published. These side effects ranged from asymptomatic increase of transaminases to fulminant liver failure necessitating transplantation. The pathomechanism is not fully understood; in some case reports autoimmune phenomena have been described.
authors.affiliation: Gastroenterologie, Rems-Murr-Klinik-Schorndorf, Schlichtener Str. 105, 73614, Schorndorf, Deutschland. rica.forker@rems-murr-kliniken.de.
authors.forename: R
authors.initials: R
authors.lastname: Forker
authors.affiliation: Gastroenterologische Schwerpunktpraxis, Leonberg, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Escher
authors.affiliation: Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Robert-Bosch-Krankenhaus Stuttgart, Stuttgart, Deutschland.
authors.forename: E F
authors.initials: EF
authors.lastname: Stange
mesh_terms: D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000188:drug therapy*; D003937:Diagnosis, Differential; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D000069285:Infliximab / Q000009:adverse effects* / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000175:diagnosis; D008111:Liver Function Tests; D011239:Prednisolone / Q000627:therapeutic use; D012812:Sigmoidoscopy; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D011239:Prednisolone; D000069285:Infliximab; D006854:Hydrocortisone; D016559:Tacrolimus
keywords: Antibodies; Drug-induced liver injury; Hepatitis, autoimmune; Infliximab; Tumor necrosis factor-α