title: Ultrastructure of Immune Synapses.
abstract: The immunological synapse is a critical event for immune response development. The use of planar supported bilayers as surrogate antigen-presenting cells is a useful tool to study this phenomenon. Here we describe electron microscopy methods and approaches to expand our knowledge of the events taking place during the initial phases of T cell activation after antigen recognition at the nanometer scale.
authors.affiliation: Department of Physiology, University of Bern, Hochschulstrasse 4, 3012, Bern, Switzerland. llodra@pyl.unibe.ch.
authors.forename: Jaime
authors.initials: J
authors.lastname: Llodrá
mesh_terms: D000818:Animals; D006801:Humans; D054992:Immunological Synapses / Q000276:immunology* / Q000648:ultrastructure*; D008213:Lymphocyte Activation; D008854:Microscopy, Electron / Q000379:methods*; D013601:T-Lymphocytes / Q000276:immunology* / Q000648:ultrastructure*
keywords: Correlative microscopy; Electron microscopy; Immunological synapse; Tomography