title: Vestibular impairment in Multiple Chemical Sensitivity: Component analysis findings.
abstract: Multiple chemical sensitivity (MCS) is a common clinical diagnosis in western populations and its symptoms are thought to be mainly related to chemical compounds exposure. Although MCS subjects refer to complain from many central nervous system symptoms, including dizziness, no study to now deepened vestibular detriment nor to what extent such an impairment could worsen MCS. Thus, the purpose of present study was to objectively highlight those clinical/subclinical aspects of vestibular impairment that could be related to MCS symptoms cohorts. A principal component analysis within a wide battery of otoneurological test scores was employed in 18 right-handed MCS patients and 20 sex- and age-matched healthy individuals. A deranged dimensionality in near-optimal re-weighting within otoneurological variables was found in MCS as compared with healthy subjects. These data seem to support the idea that MCS physiopathological underpinnings could lead to a peripheral and higher vestibular decay that could be addressed as a further aspect to better follow MCS patients up along natural history of disease in clinical practice.
authors.affiliation: Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.|Department of Systems Medicine, University of Rome Tor Vergata, Neuroscience Unit, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Micarelli
authors.affiliation: Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Viziano
authors.affiliation: Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Bruno
authors.affiliation: Department of Biology, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Micarelli
authors.affiliation: Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Alessandrini
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004244:Dizziness / Q000209:etiology; D005260:Female; D005583:Fourier Analysis; D064087:Head Impulse Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D018777:Multiple Chemical Sensitivity / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D009460:Neurologic Examination; D025341:Principal Component Analysis; D014717:Vertigo / Q000209:etiology; D015837:Vestibular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D014724:Vestibular Function Tests
keywords: Fourier transform; Multiple chemical sensitivity; component analysis; vestibular; visual dependency