title: Deformability Calculation for Estimation of the Relative Stability of Chemically Modified RNA Duplexes.
abstract: Chemical modification of RNA duplexes alters their stability. We have attempted to develop a computational approach to estimate the thermal stability of chemically modified duplexes. These studies revealed that the deformability of chemically modified RNA duplexes, calculated from molecular dynamics simulations, could be used as a good indicator for estimating the effect of chemical modification on duplex thermal stability. This unit describes how deformability calculation can be applied to estimate the relative stability of chemically modified RNA duplexes. © 2017 by John Wiley & Sons, Inc.
authors.affiliation: Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Masaki
authors.affiliation: Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Sekine
authors.affiliation: Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
authors.forename: Kohji
authors.initials: K
authors.lastname: Seio
mesh_terms: D056004:Molecular Dynamics Simulation; D009841:Oligonucleotides / Q000737:chemistry; D012313:RNA / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D012313:RNA
keywords: RNA; chemical modification; deformability; duplex thermal stability; nucleic acid