title: Detection of Low Adherence in Rural Tuberculosis Patients in China: Application of Morisky Medication Adherence Scale.
abstract: The detection and analysis of cases of low medication adherence is important for helping to control tuberculosis (TB). The purpose of this study was to detect low adherence in rural TB patients by using the eight-item Morisky Medication Adherence Scale of Chinese version (C-MMAS-8) and to further analyze the adherence-related variables. A total of 358 rural TB patients recruited through multi-stage randomized sampling participated in the survey. Data were collected by the use of interviewer-led questionnaires. First, the reliability and validity of the C-MMAS-8 were determined. Second, the adherence level was assessed, and factors related to low adherence were analyzed by using Pearson's chi-square test and then in multiple logistic regression model. Finally, the prediction of the logistic model was assessed with Receiver Operating Characteristic (ROC) curves. The C-MMAS-8 could be used to detect low adherence in TB patients with good reliability and validity. By using the referred cutoff points of MMAS-8, it was found that more than one-third of the participants had low medication adherence. Further analysis revealed the variables of being older, a longer treatment time, and being depressive were significantly related to low adherence. The ROC of the model was assessed as good using the cutoff point. We conclude that appropriately tailored strategies are needed for health-care providers to help rural TB patients cope with low medication adherence.
authors.affiliation: School of Public Health, Shandong University, Jinan 250012, China. xuminlan@sdu.edu.cn.|Department of Social Work, Umeå University, 901 87 Umeå, Sweden. xuminlan@sdu.edu.cn.
authors.forename: Minlan
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Social Work, Umeå University, 901 87 Umeå, Sweden. urban.markstrom@umu.se.
authors.forename: Urban
authors.initials: U
authors.lastname: Markström
authors.affiliation: Department of Public Health, Weifang Medical University, Weifang 261042, China. cheng_china@163.com.
authors.forename: Juncheng
authors.initials: J
authors.lastname: Lyu
authors.affiliation: School of Public Health, Shandong University, Jinan 250012, China. lzxu@sdu.edu.cn.
authors.forename: Lingzhong
authors.initials: L
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D011594:Psychometrics; D012372:ROC Curve; D015203:Reproducibility of Results; D012424:Rural Population; D011795:Surveys and Questionnaires; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000523:psychology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents
keywords: C-MMAS-8; associated factors; medication adherence; reliability; tuberculosis; validity