title: A new unsaturated derivative of hyaluronic acid - Synthesis, analysis and applications.
abstract: Hyaluronic acid (HA) containing CC double bond in positions 4 and 5 of N-acetyl-glucosamine ring (ΔHA) is an unique material, which could be used for biomedical applications and cosmetics. The main advantage of the CC double bond is its ability to react with a wide range of oxidation agents. Location of the CC double bond directly on the glucopyranose ring allows to change the chemical capabilities and simultaneously to mimic the intrinsic physical properties of HA without introduction of linkers or other substances. The synthesis, structural analysis and basic chemical and biological characteristics of this novel biopolymer are described in details. In vitro cytotoxicity assays showed selective activity of ΔHA against cancer cell lines in comparison with standard human fibroblasts so this material has great potential in the field of anticancer drugs.
authors.affiliation: Contipro a.s., Dolní Dobrouč 401, 56102, Czechia. Electronic address: buffa@contipro.com.
authors.forename: Radovan
authors.initials: R
authors.lastname: Buffa
authors.affiliation: Contipro a.s., Dolní Dobrouč 401, 56102, Czechia.
authors.forename: Petra
authors.initials: P
authors.lastname: Šedová
authors.affiliation: Contipro a.s., Dolní Dobrouč 401, 56102, Czechia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Basarabová
authors.affiliation: Contipro a.s., Dolní Dobrouč 401, 56102, Czechia.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Bobula
authors.affiliation: Contipro a.s., Dolní Dobrouč 401, 56102, Czechia.
authors.forename: Pavlína
authors.initials: P
authors.lastname: Procházková
authors.affiliation: Contipro a.s., Dolní Dobrouč 401, 56102, Czechia.
authors.forename: Hana
authors.initials: H
authors.lastname: Vágnerová
authors.affiliation: Contipro a.s., Dolní Dobrouč 401, 56102, Czechia.
authors.forename: Iva
authors.initials: I
authors.lastname: Dolečková
authors.affiliation: Contipro a.s., Dolní Dobrouč 401, 56102, Czechia.
authors.forename: Soňa
authors.initials: S
authors.lastname: Moravčíková
authors.affiliation: Contipro a.s., Dolní Dobrouč 401, 56102, Czechia.
authors.forename: Lenka
authors.initials: L
authors.lastname: Hejlová
authors.affiliation: Contipro a.s., Dolní Dobrouč 401, 56102, Czechia.
authors.forename: Vladimír
authors.initials: V
authors.lastname: Velebný
keywords: Addition; Anticancer; Antioxidation; Hyaluronan; Oxidation