title: Metal-catalyzed Decarboxylative Fluoroalkylation Reactions.
abstract: Metal-catalyzed decarboxylative fluoroalkylation reactions enable the conversion of simple O-based substrates into biologically relevant fluorinated analogs. Herein, we present decarboxylative methods that facilitate the synthesis of trifluoromethyl- and difluoroketone-containing products. We highlight key mechanistic aspects that are critical for efficient catalysis, and that inspired our thinking while developing the reactions.
authors.affiliation: Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.
authors.forename: Brett R
authors.initials: BR
authors.lastname: Ambler
authors.affiliation: Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.
authors.forename: Ming-Hsiu
authors.initials: MH
authors.lastname: Yang
authors.affiliation: Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Altman
keywords: Catalysis; Copper; Decarboxylation; Difluoroketone; Fluorine; Palladium; Trifluoromethylation