title: Effect of weight loss on activity in psoriatic arthritis: A systematic review.
abstract: OBJECTIVE
  To evaluate the association between weight loss and changes in disease activity in patients with psoriatic arthritis (PsA).
  
  
  METHODS
  We performed a systematic review of the literature, with searches in Medline, Embase and Cochrane Central Library from inception until April 2015.
  
  
  METHODS
  1) randomized controlled trials (RCT); 2) PsA patients; 3) interventions were any intervention aimed at weight control; and 4) a PsA activity-related outcome measure was evaluated. Risks of bias were assessed by the Cochrane Collaboration scale.
  
  
  RESULTS
  Of the 215 articles identified, only 2 RCT met the inclusion criteria, 1 in abstract format. Both showed moderate risk of bias. Patients who managed to lose weight-by any method-had better results in terms of activity and inflammation. The percentage of weight loss correlated moderately with changes in inflammatory outcomes.
  
  
  CONCLUSIONS
  Weight loss in PsA could be associated with less inflammation; however, the evidence to support this is limited.
authors.affiliation: Hospital Universitario Fundación Alcorcón, Madrid, España. Electronic address: ralmodovar@fhalcorcon.es.
authors.forename: Raquel
authors.initials: R
authors.lastname: Almodóvar
authors.affiliation: Hospital Universitario Fundación Alcorcón, Madrid, España.
authors.forename: Pedro
authors.initials: P
authors.lastname: Zarco
authors.affiliation: Instituto de Salud Musculoesquelética, InMusc, Madrid, España.
authors.forename: Teresa
authors.initials: T
authors.lastname: Otón
authors.affiliation: Instituto de Salud Musculoesquelética, InMusc, Madrid, España.
authors.forename: Loreto
authors.initials: L
authors.lastname: Carmona
mesh_terms: D015535:Arthritis, Psoriatic / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D009765:Obesity / Q000150:complications / Q000628:therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*
keywords: Artritis psoriásica; Body mass index; Diet; Dieta; Obesidad; Obesity; Psoriatic arthritis; Pérdida de peso; Response to treatment; Respuesta al tratamiento; Weight loss; Índice de masa corporal