title: Neural correlates of adaptive working memory training in a glycogen storage disease type-IV patient.
abstract: Glycogen storage disease type-IV has varied clinical presentations and subtypes. We evaluated a 38-year-old man with memory complaints, common symptoms in adult polyglucosan body disease subtype, and investigated cognitive and functional MRI changes associated with two 25-sessions of adaptive working memory training. He showed improved trained and nontrained working memory up to 6-months after the training sessions. On functional MRI, he showed increased cortical activation 1-3 months after training, but both increased and decreased activation 6-months later. Working memory training appears to be beneficial to patients with adult polyglucosan body disease, although continued training may be required to maintain improvements.
authors.affiliation: Department of Medicine University of Hawai'i at Mānoa Honolulu Hawaii.
authors.forename: Kristin
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Medicine University of Hawai'i at Mānoa Honolulu Hawaii.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ernst
authors.affiliation: Department of Laboratory Medicine Childrens and Women's Health Norwegian University of Science and Technology Trondheim Norway; Department of Pediatrics Sørlandet Hospital Arendal Norway.
authors.forename: Gro
authors.initials: G
authors.lastname: Løhaugen
authors.affiliation: Department of Medicine University of Hawai'i at Mānoa Honolulu Hawaii.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Medicine University of Hawai'i at Mānoa Honolulu Hawaii.
authors.forename: Linda
authors.initials: L
authors.lastname: Chang
keywords: fMRI; glycogen storage disease; memory