title: Outcome of Renal Transplant in Recipients With Vasculitis.
abstract: OBJECTIVE
  End-stage renal disease develops in a high percentage of patients with vasculitis, in whom kidney transplant has become a therapeutic option. However, limited data are available on the prognosis and outcomes after kidney transplant in these patients. We aimed to compare the long-term graft survival and graft function in 8 renal transplant recipients with vasculitis (granulomatosis with polyangiitis, microscopic polyangiitis, Goodpasture syndrome, and Henoch-Schonlein purpura) with the other kidney recipients at a single center.
  
  
  METHODS
  We conducted a retrospective study of patients followed for chronic renal failure associated with vasculitis before renal transplant. We excluded patients with no biopsy-proven nephropathy.
  
  
  RESULTS
  There was no difference in the occurrence of metabolic and cardiovascular complications in our case group compared with the other graft recipients. Infections were frequent and included cytomegalovirus and urinary tract infection. The rates of bacterial and viral infection were equivalent in our population. The incidence of allograft loss was estimated at 1.8%, less than that seen in our entire transplant population. The presence of vasculitis was not significantly related to renal failure (P = .07). Extrarenal relapse occurred in 1 patient with microscopic polyangiitis. Antineutrophil cytoplasmic antibody levels in patients with granulomatosis with polyangiitis and microscopic polyangiitis did not seem to influence the renal outcome (P = .08). Circulating antineutrophil cytoplasmic antibodies were associated with the development of vascular lesions in the graft but were not significantly correlated with graft survival (P = .07).
  
  
  CONCLUSIONS
  This study supports the theory that renal transplant is an effective treatment option for patients with end-stage renal disease secondary to vasculitis. These patients fare similarly to, if not better than, other patients.
authors.affiliation: Department of Nephrology, Charles Nicolle Hospital, Tunis, Tunisia.
authors.forename: Samia
authors.initials: S
authors.lastname: Barbouch
authors.forename: Meriam
authors.initials: M
authors.lastname: Hajji
authors.forename: Raja
authors.initials: R
authors.lastname: Aoudia
authors.forename: Monther
authors.initials: M
authors.lastname: Ounissi
authors.forename: Asma
authors.initials: A
authors.lastname: Zammouri
authors.forename: Rym
authors.initials: R
authors.lastname: Goucha
authors.forename: Fathi
authors.initials: F
authors.lastname: Ben Hamida
authors.forename: Mohammed Mongi
authors.initials: MM
authors.lastname: Bacha
authors.forename: Ezzedine
authors.initials: E
authors.lastname: Abderrahim
authors.forename: Taieb
authors.initials: T
authors.lastname: Ben Abdallah
mesh_terms: D000328:Adult; D002648:Child; D005260:Female; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014657:Vasculitis / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D055815:Young Adult