title: Mineral binding peptides with enhanced binding stability in serum.
abstract: Although calcium phosphate (CaP) binding peptides are used to link orthobiologics to orthopedic biomaterials, their binding stability in physiological environment is still unknown. In this study, we investigate the binding capability of a series of CaP-binding peptides and their binding stability in serum solutions, which are selected to resemble physiological conditions. The findings in this study may be applicable for designing robust orthobiologic delivery systems.
authors.affiliation: Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA. wlmurphy@wisc.edu.
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA. wlmurphy@wisc.edu.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Wagoner Johnson
authors.affiliation: Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA. wlmurphy@wisc.edu and Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI 53792, USA and Materials Science Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors.forename: William L
authors.identifier: http://orcid.org/0000-0001-5577-7739
authors.initials: WL
authors.lastname: Murphy
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002130:Calcium Phosphates / Q000378:metabolism*; D002417:Cattle; D016503:Drug Delivery Systems; D017886:Durapatite / Q000378:metabolism; D006801:Humans; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D044967:Serum / Q000378:metabolism*
chemical_list: D002130:Calcium Phosphates; D010455:Peptides; D017886:Durapatite; C020243:calcium phosphate