title: Intraventricular gliosarcoma with dual sarcomatous differentiation: A unique case.
abstract: Gliosarcoma, a variant of isocitrate dehydrogenase-wildtype glioblastoma, is largely a lobar surfacing neoplasm often with dural attachment. In this biphasic neoplasm, the sarcomatous component usually takes the form of fibrosarcoma or malignant fibrous histiocytoma. Heterologous sarcomatous differentiation is a rare phenomenon. Here, we present a case of gliosarcoma with liposarcomatous and myosarcomatous differentiation in a 68-year-old man which was purely intraventricular. This is the first report of such a morphologic pattern in this location. Varied histological components with their immunohistochemical profile are discussed. Of note was the presence of a p53 negative giant cell glioblastoma component, as was the expression in the rest of the tumor.
authors.affiliation: Department of Neuropathology, NIMHANS, Bangalore, Karnataka, India.
authors.forename: Rajalakshmi
authors.initials: R
authors.lastname: Poyuran
authors.affiliation: Department of Neuropathology, NIMHANS, Bangalore, Karnataka, India.
authors.forename: Nandeesh
authors.initials: N
authors.lastname: Bn
authors.affiliation: Department of Neurosurgery, NIMHANS, Bangalore, Karnataka, India.
authors.forename: Yerasi Varun Kumar
authors.initials: YVK
authors.lastname: Reddy
authors.affiliation: Department of Neurosurgery, NIMHANS, Bangalore, Karnataka, India.
authors.forename: Amey R
authors.initials: AR
authors.lastname: Savardekar
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology*; D018316:Gliosarcoma / Q000473:pathology*; D006801:Humans; D008297:Male
keywords: gliosarcoma; intraventricular; liposarcomatous; myosarcomatous; p53