title: Toll-Like Receptor 2 and Its Relationship With Streptococcus in Psoriasis.
abstract: The authors present the immunopathologic findings of Toll-like receptor 2 in psoriasis. This novel work shows positive staining within the dermal capillaries in psoriatic lesions. Neither normal skin nor lesional skin in eczema showed similar staining. The authors postulate how the activation of this innate immune system reactant plays a significant role in psoriasis and show how it may be associated with a cascade of events that begins with streptococcus and ends with psoriasis.
authors.affiliation: Department of Dermatology, Drexel University College of Medicine, Philadelphia, PA.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Drexel University College of Medicine, Philadelphia, PA.
authors.forename: Christine
authors.initials: C
authors.lastname: Shaver
authors.affiliation: Department of Dermatology, Drexel University College of Medicine, Philadelphia, PA.
authors.forename: Lane
authors.initials: L
authors.lastname: Neidig
authors.affiliation: Department of Dermatology, Drexel University College of Medicine, Philadelphia, PA.
authors.forename: Krister
authors.initials: K
authors.lastname: Jones
authors.affiliation: Department of Dermatology, Drexel University College of Medicine, Philadelphia, PA.
authors.forename: Carrie A
authors.initials: CA
authors.lastname: Cusack
authors.affiliation: Department of Dermatology, Drexel University College of Medicine, Philadelphia, PA; hallen@drexelmed.edu.
authors.forename: Herbert B
authors.initials: HB
authors.lastname: Allen
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008297:Male; D011379:Prognosis; D011565:Psoriasis / Q000209:etiology / Q000382:microbiology* / Q000503:physiopathology*; D018570:Risk Assessment; D013194:Staining and Labeling; D013290:Streptococcal Infections / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D013291:Streptococcus / Q000276:immunology / Q000472:pathogenicity; D051195:Toll-Like Receptor 2 / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D051195:Toll-Like Receptor 2