title: Improvement of the mechanical properties and corrosion resistance of biodegradable β-Ca3(PO4)2/Mg-Zn composites prepared by powder metallurgy: the adding β-Ca3(PO4)2,hot extrusion and aging treatment.
abstract: In this study, 10%β-Ca3(PO4)2/Mg-6%Zn (wt.%) composites with Mg-6%Zn alloy as control were prepared by powder metallurgy. After hot extrusion, the as-extruded composites were aged for 72h at 150°C. The effects of the adding β-Ca3(PO4)2, hot extrusion and aging treatment on their microstructure, mechanical properties and corrosion resistance were investigated. The XRD results identified α-Mg, MgZn phase and β-Ca3(PO4)2phase in these composites. After hot extrusion, grains were significantly refined, and the larger-sized β-Ca3(PO4)2particles and coarse MgZn phases were broken into linear-distributed β-Ca3(PO4)2and MgZn phases along the extrusion direction. After aging treatment, the elements of Zn, Ca, P and O presented a more homogeneous distribution. The compressive strengths of the β-Ca3(PO4)2/Mg-Zn composites were approximately double those of natural bone, and their densities and elastic moduli matched those of natural bone. The immersion tests and electrochemical tests revealed that the adding β-Ca3(PO4)2, hot extrusion and aging treatment could promote the formation of protective corrosion product layer on the sample surface in Ringer's solution, which improved corrosion resistance of the β-Ca3(PO4)2/Mg-Zn composites. The XRD results indicated that the corrosion product layer contained Mg(OH)2, β-Ca3(PO4)2and hydroxyapatite (HA). The cytotoxicity assessments showed the as-extruded β-Ca3(PO4)2/Mg-Zn composite aged for 72h was harmless to L-929 cells. These results suggested that the β-Ca3(PO4)2/Mg-Zn composites prepared by powder metallurgy were promising to be used for bone tissue engineering.
authors.affiliation: School of Materials Science and Engineering, Central South University, Changsha 410083, China; Department of Materials Science and Engineering, Yantai Nanshan University, Yantai 265713, China; Orthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha 410011, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yan
authors.affiliation: The Second Xiangya Hospital, Central South University, 410011, China; Orthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha 410011, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Kang
authors.affiliation: School of Materials Science and Engineering, Central South University, Changsha 410083, China; The Second Xiangya Hospital, Central South University, 410011, China; Orthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha 410011, China.
authors.forename: Ding
authors.initials: D
authors.lastname: Li
authors.affiliation: School of Materials Science and Engineering, Central South University, Changsha 410083, China; Department of Materials Science and Engineering, Yantai Nanshan University, Yantai 265713, China; Orthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha 410011, China. Electronic address: yukun2010@csu.edu.cn.
authors.forename: Kun
authors.initials: K
authors.lastname: Yu
authors.affiliation: The Second Xiangya Hospital, Central South University, 410011, China; Orthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha 410011, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xiao
authors.affiliation: The Second Xiangya Hospital, Central South University, 410011, China; Orthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha 410011, China.
authors.forename: Youwen
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Materials Science and Engineering, Yantai Nanshan University, Yantai 265713, China.
authors.forename: Han
authors.initials: H
authors.lastname: Dai
authors.affiliation: School of Materials Science and Engineering, Central South University, Changsha 410083, China; Department of Materials Science and Engineering, Yantai Nanshan University, Yantai 265713, China.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Dai
authors.affiliation: School of Materials Science and Engineering, Central South University, Changsha 410083, China; Department of Materials Science and Engineering, Yantai Nanshan University, Yantai 265713, China.
authors.forename: Hanqing
authors.initials: H
authors.lastname: Xiong
authors.affiliation: Department of Materials Science and Engineering, Yantai Nanshan University, Yantai 265713, China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Fang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D019245:Compressive Strength; D003343:Corrosion; D055664:Electrochemical Techniques; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D008669:Metallurgy; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D013696:Temperature; D013997:Time Factors; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D008274:Magnesium; D015032:Zinc
keywords: Aging treatment; Corrosion behavior; Cytocompatibility; Hot extrusion; Mechanical properties; β-Ca(3)(PO(4))(2)/Mg-Zn composite