title: Moving towards totipotency without a single miR-acle.
abstract: Totipotency is the ability of a single cell to form an entire embryo, including extraembryonic tissues, an ability we have yet to recapitalize, in vitro. In a recent paper published in Science, Choi et al. showed that pluripotent stem cells lacking microRNA miR-34a, have an expanded cell fate potential allowing differentiation into not only embryonic but also extraembryonic lineages.
authors.affiliation: Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
authors.forename: Noam
authors.initials: N
authors.lastname: Maoz
authors.affiliation: Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
authors.forename: Yosef
authors.initials: Y
authors.lastname: Buganim
mesh_terms: D002454:Cell Differentiation; D035683:MicroRNAs; D039904:Pluripotent Stem Cells
chemical_list: D035683:MicroRNAs