title: [Pregnancy outcomes in women with gestational diabetes: specific subgroups might require increased attention].
abstract: OBJECTIVE
  To compare peri-partal parameters between two groups of pregnant women - with and without gestational diabetes mellitus (GDM), to correlate degree of glucose abnormality with incidence of peri-partal morbidity and, finally, to analyse the potential effect of comorbidities (i.e. obesity, hypertension, thyreopathy, polycystic ovary syndrome, trombophylia, anemia, allergy, smoking) on pregnancy outcomes.
  
  
  METHODS
  Epidemiological observational "case-control" study.
  
  
  METHODS
  Department of Obstetric and Gynaecology, Faculty Hospital Brno; Department of Internal Medicine, Diabetes Centre, Faculty Hospital Brno; Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno.
  
  
  METHODS
  The study comprised 432 pregnant women (364 with GDM diagnosis, 68 healthy controls) followed during a period 2011-2013. GDM was diagnosed by oral glucose tolerance test in 24-28th week of gestation (by fasting plasma glucose >5,6 mmol/l or >8,8 mmol/l in 60th min or >7,8 mmol/l in 120th min post-75g glucose load). Following peri-partal parameters were studied: ultrasonographic examination before delivery, a date of delivery, length of childbirth, induction, perinatal complications, post-delivery complications, section, abnormity in pH, base excess, Apgar score, birth weight.
  
  
  RESULTS
  Subjects with GDM had significantly increased rate of labour induction compared to healthy controls (P = 0.0035, chi-square test). Subgroup of GDM women classified as having a higher risk for adverse perinatal outcomes by a definition of Czech Obstetric and Gynaecology Society had significantly more labour inductions, more sections and instrumental deliveries. New-borns of those mothers had significantly more common worse perinatal outcomes (Apgar score and macrosomia).
  
  
  CONCLUSIONS
  Based on our data risk stratification of GDM subjects according to Czech Obstetric and Gynaecology Society appears relevant and justified.
authors.forename: V
authors.initials: V
authors.lastname: Bartáková
authors.forename: V
authors.initials: V
authors.lastname: Ťápalová
authors.forename: K
authors.initials: K
authors.lastname: Wágnerová
authors.forename: P
authors.initials: P
authors.lastname: Janků
authors.forename: J
authors.initials: J
authors.lastname: Bělobrádková
authors.forename: K
authors.initials: K
authors.lastname: Kaňková
mesh_terms: D000328:Adult; D000740:Anemia / Q000453:epidemiology; D001034:Apgar Score; D001288:Attention; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data; D015897:Comorbidity; D018153:Czech Republic / Q000453:epidemiology; D036861:Delivery, Obstetric; D016640:Diabetes, Gestational / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D007231:Infant, Newborn; D007751:Labor, Induced / Q000706:statistics & numerical data; D007743:Labor, Obstetric; D009765:Obesity / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012907:Smoking / Q000453:epidemiology; D019851:Thrombophilia / Q000453:epidemiology; D013959:Thyroid Diseases / Q000453:epidemiology
chemical_list: D001786:Blood Glucose
keywords: gestational diabetes mellitus; impaired glucose tolerance perinatal morbidity.; pregnancy