title: The incidence of new onset diabetes after transplantation and related factors: Single center experience.
abstract: OBJECTIVE
  New-onset diabetes after transplantation (NODAT) is a frequent metabolic complication and is considered a risk factor for patients undergoing renal transplant. The aim of this study was to evaluate the incidence and developing duration of new-onset diabetes after transplant (NODAT) and influencing factors.
  
  
  METHODS
  All patients' data was investigated retrospectively. Diabetics, follow-up period<6 months, age<18years were excluded. Demographic, clinical and laboratory data was recorded. Patients were divided into two groups: with/without NODAT. NODAT group was divided into four subgroups according to the time of developing NODAT, which were 0-3, 3-6, 6-12 and 12 months later. Two groups were compared, to investigate the incidence of NODAT and risk factors associated with the occurrence of NODAT.
  
  
  RESULTS
  We retrospectively analyzed the records of 570 patients, of which 420 patients were included. Seventy (16.6%) patients had NODAT (36 female, mean age 51.7±8.2 years, mean follow-up 41.6±21.5 months), 52.8% of patients developed NODAT within the first three months of being diagnosed. 350 patients (116 female, mean age 43.2±12.5 years, mean follow-up 41.6±21.5 months) were without NODAT. The incidence of impaired fasting glucose (IFG) during the first week after transplant was found to be higher in the patients with NODAT (p<0.001). There was positive correlation between NODAT and older age, obesity, family history of diabetes, presence of IFG, fasting plasma glucose, total and LDL-cholesterol, triglycerides, parathormone. Old age, obesity, presence of IFG, pretransplant hypertriglyceridemia and hyperparathyroidism were predictors of development of NODAT.
  
  
  CONCLUSIONS
  Incidence of NODAT, especially the first six months, was high. All patients should be screened for IFG within the first week. Patients with dyslipidemia, elderly and obese patients should be closely monitored for the risk of development of NODAT.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Istanbul Bilim University, Istanbul, Turkey. Electronic address: aysesinangil@gmail.com.
authors.forename: Ayse
authors.initials: A
authors.lastname: Sinangil
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Istanbul Bilim University, Istanbul, Turkey.
authors.forename: Vedat
authors.initials: V
authors.lastname: Celik
authors.affiliation: Renal Transplantation Unit, Istanbul Bilim University, Istanbul, Turkey.
authors.forename: Soykan
authors.initials: S
authors.lastname: Barlas
authors.affiliation: Department of Nephrology, Sisli Hamidiye Etfal Research and Educational Hospital, Istanbul, Turkey.
authors.forename: Yener
authors.initials: Y
authors.lastname: Koc
authors.affiliation: Department of Nephrology, Sisli Hamidiye Etfal Research and Educational Hospital, Istanbul, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Basturk
authors.affiliation: Department of Nephrology, Sisli Hamidiye Etfal Research and Educational Hospital, Istanbul, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Sakaci
authors.affiliation: Renal Transplantation Unit, Istanbul Bilim University, Istanbul, Turkey.
authors.forename: Emin Baris
authors.initials: EB
authors.lastname: Akin
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Istanbul Bilim University, Istanbul, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Ecder
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies
keywords: Alteración de la glucemia en ayunas; DMPT; Impaired fasting glucose; PTDM; Renal transplantation; Trasplante renal