title: INFORMATIONAL STRESS AS A DEPRESSION INDUCING FACTOR (EXPERIMENTAL STUDY).
abstract: Chronic psychogenic stress represents the major initiating agent of psychoneural diseases including depression. We used informational stress model for the purpose of modelling chronic psychogenic stress and depression. The aim of the research was to study behavior of dominant and submissive rats at different stages of informational stress and during depression state. In order to study anxiety and depressive behavior of rats we used "forced swim", "elevated cross maze" and "open-field" tests. The obtained results showed that chronic stressing procedure performed on rats by using the mentioned "informational" stress model led to the development of depression both in dominant and submissive rats. Stressing procedure caused sharp increase of serotonin concentration in hypothalamus of dominant and submissive rats. Under behavioral depression background, sharp increase of serotonin concentration in hypothalamus has been revealed which is caused by the peculiarities of stress model (by uncontrollable stressor. Specifically, by inevitable electric painful irritation).
authors.affiliation: I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Matitaishvili
authors.affiliation: I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Domianidze
authors.affiliation: I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: G
authors.initials: G
authors.lastname: Burdjanadze
authors.affiliation: I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: D
authors.initials: D
authors.lastname: Nadareishvili
authors.affiliation: I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Khananashvili
mesh_terms: D000818:Animals; D003220:Conflict, Psychological; D003863:Depression / Q000209:etiology* / Q000523:psychology; D004291:Dominance-Subordination; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D013315:Stress, Psychological / Q000150:complications / Q000523:psychology*
chemical_list: D012701:Serotonin