title: Correlation of Systemic Inflammatory Status and Cardiac Myonecrosis in Patients Undergoing Percutaneoues Coronary Intervention.
abstract: Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Pre-Percutaneoues coronary intervention (PCI) plasma hs-CRP concentration has been reported to influence both short and long term outcome after percutaneoues coronary intervention (PCI). Studies have reported association between pre-PCI CRP and PCI induced cardiac myonecrosis evaluated by sensitive marker of myocardial injury. The present study attempts to evaluate the influence of pre-PCI CRP levels, factors related to the procedure and ongoing medications on the event of post-PCI cardiac myonecrosis. This prospective observational study was done in a Tertiary referral hospital (St. James's Hospital, Dublin, Ireland) involving 38 patients with normal pre-procedural serum troponin T (<0.03μg/litre) undergoing elective PCI. Significantly high basal levels of hs-CRP was detectable in >60% patients undergoing elective PCI. This was further increased to >65% after PCI. Median value of hs-CRP before PCI was 3.61 (range 0.21-47.2mg/L). This value increased to 4.58 (range 0.44-39.2mg/L) after PCI (p<0.05). Though there was significant increase in the post-PCI median value (compared to the pre-PCI value) of TnT (0.015 vs. 0.01μg/L; p<0.001) and CKMBM (4.54 vs. 2.40μg/L; p<0.001), no significant correlation was found between pre-PCI hsCRP and post-PCI TnT (spearman correlation coefficient - 0.074; p=NS) as well as post-PCI CKMBM (spearman correlation coefficient - 0.036; p=NS). The changes in the values of TnT & CKMBM showed moderate positive correlation (spearman correlation coefficient - 0.52; p<0.001). Procedural parameters (of balloon dilatation and stent implantation) did not have significant correlation either. No significant influence of age and ongoing medications was found. Increased hs-CRP levels in serum before PCI was not correlated with significant cardiac myonecrosis detected after PCI.
authors.affiliation: Dr Md Khaled Mohsin, Senior Consultant, &Associate Professor, Cardiology, National Heart Foundation Hospitals & RI, Mirpur, Dhaka, Bangladesh.
authors.forename: M K
authors.initials: MK
authors.lastname: Mohsin
authors.forename: M U
authors.initials: MU
authors.lastname: Ahmed
mesh_terms: D015415:Biomarkers; D002097:C-Reactive Protein; D009202:Cardiomyopathies / Q000473:pathology; D006801:Humans; D009203:Myocardial Infarction / Q000276:immunology / Q000628:therapy; D009336:Necrosis; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein