title: Tandem 1,6-addition/cyclization/vinylcyclopropane rearrangement at low temperature under metal-free conditions: an approach to spiro[4.5]cyclohexadienones.
abstract: A tandem 1,6-addition/cyclization/vinylcyclopropane rearrangement reaction (VCPR) of vinylogous para-quinone methides at low temperature under metal-free conditions has been disclosed for the first time. This method provides an efficient strategy for the construction of a range of spiro[4.5]cyclohexadienones in good yield, exhibiting good functional group tolerance as well as gram-scale capacity.
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, P. R. China. hyao@cpu.edu.cn cpuhyao@126.com.
authors.forename: Zhenbo
authors.initials: Z
authors.lastname: Yuan
authors.forename: Kuo
authors.initials: K
authors.lastname: Gai
authors.forename: Youzhi
authors.initials: Y
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: Aijun
authors.initials: A
authors.lastname: Lin
authors.forename: Hequan
authors.initials: H
authors.lastname: Yao