title: In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography.
abstract: Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that 18F-AV-1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction.
  
  
  
  To describe tau aggregation in PD patients.
  
  
  
  Twenty-six PD patients and 23 controls had 18F-AV-1451 PET and neuropsychological assessment to detect mild cognitive impairment.
  
  
  
  Nine PD patients (35%) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel-wise analyses showed no correlation with cognitive domain z-scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0.
  
  
  
  Our results indicate that tau pathology, as detected by 18F-AV-1451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage. © 2017 International Parkinson and Movement Disorder Society.
authors.affiliation: Dept of Nuclear Medicine & PET Centre, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: Allan K
authors.initials: AK
authors.lastname: Hansen
authors.affiliation: Unit of Psychooncology and Health psychology, Dept of Psychology and Behavioral Sciences, Aarhus University, Aarhus, Denmark.
authors.forename: Malene Flensborg
authors.initials: MF
authors.lastname: Damholdt
authors.affiliation: Dept of Nuclear Medicine & PET Centre, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: Tatyana D
authors.initials: TD
authors.lastname: Fedorova
authors.affiliation: Dept of Nuclear Medicine & PET Centre, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: Karoline
authors.initials: K
authors.lastname: Knudsen
authors.affiliation: Dept of Nuclear Medicine & PET Centre, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Parbo
authors.affiliation: Dept of Nuclear Medicine & PET Centre, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: Rola
authors.initials: R
authors.lastname: Ismail
authors.affiliation: Dept of Neurology, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: Karen
authors.initials: K
authors.lastname: Østergaard
authors.affiliation: Dept of Nuclear Medicine & PET Centre, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.|Division of Neuroscience, Dept of Medicine, Imperial College London, United Kingdom.|Division of Neuroscience, Newcastle University, United Kingdom.
authors.forename: David J
authors.initials: DJ
authors.lastname: Brooks
authors.affiliation: Dept of Nuclear Medicine & PET Centre, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: Per
authors.initials: P
authors.lastname: Borghammer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002243:Carbolines; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods*; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D002243:Carbolines; D016875:tau Proteins; C000591008:7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole
keywords: AV-1451; MCI; Parkinson's disease; Tau; imaging