title: Electrospinning of gelatin and SMPU with carbon nanotubes for tissue engineering scaffolds.
abstract: The nanofibres created by electrospinning technique are currently used for a variety of applications in tissue engineering; and Gelatin and Polyurethane Shape-Memory (SMPU) have important results in biomedicine. Similarly, carbon nanotubes combined with other biomaterials change important properties, opening new opportunities for biomedical applications. In this work, we constructed scaffold using electrospinning technique based in bovine-hide gelatin, SMPU and both materials hybrid with carbon nanotube. Morphology and cytotoxicity were evaluated and mechanical properties for two materials were obtained in scaffold building. Morphological, mechanical and citotoxic properties of the electrospun fibers were found to be dependent of alteration in materials concentration, electrospinning conditions and MWCNT concentration. According to morphological, cytotoxic and mechanical analysis, SMPU more MWCNT were the best material, with nanofibers of 451 nm, tensile strength of 1.912 MPa, and a high ratio surface volume.
authors.forename: Monica A
authors.initials: MA
authors.lastname: Mejia
authors.forename: Lina M
authors.initials: LM
authors.lastname: Hoyos
authors.forename: Jenniffer
authors.initials: J
authors.lastname: Zapata
authors.forename: Luz M
authors.initials: LM
authors.lastname: Restrepo
authors.forename: Maria E
authors.initials: ME
authors.lastname: Moneada
mesh_terms: D000818:Animals; D002417:Cattle; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005780:Gelatin / Q000737:chemistry*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry / Q000633:toxicity; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000633:toxicity; D011140:Polyurethanes / Q000737:chemistry; D013718:Tensile Strength; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D037742:Nanotubes, Carbon; D011140:Polyurethanes; D005780:Gelatin