title: Use of cancer antigen 125, cancer antigen 19-9, and the neutrophil-to-lymphocyte ratio to diagnose mature cystic teratoma with torsion.
abstract: OBJECTIVE
  To determine the efficacy of serum levels of cancer antigen 125 (CA125) and cancer antigen 19-9 (CA19-9), and the neutrophil-to-lymphocyte ratio (NLR) for diagnosis of mature cystic teratoma (MCT) with torsion.
  
  
  METHODS
  A retrospective medical record review was conducted of data for women who had undergone surgery for ovarian MCT at the First Affiliated Hospital of Wenzhou Medical University, China, between January 1, 2008, and January 1, 2015. Patients with torsion and a control group who underwent surgery on the same days were identified. Clinical characteristics and the serum levels of CA125, CA19-9, and the NLR were assessed.
  
  
  RESULTS
  The serum levels of CA125, CA19-9, and the NLR were higher in the torsion group (n=68) than in the control group (n=120; P≤0.001 for all). Receiver operating characteristic analysis indicated that the area under the curve for the combined use of CA125, CA19-9, and NLR was 0.978 (95% confidence interval 0.954-1.000; P<0.001). This combination had a diagnostic sensitivity of 93.9% and a specificity of 98.3%. Moreover, levels of these inflammatory markers were significantly increased among patients with large tumor diameters (P<0.01 for all).
  
  
  CONCLUSIONS
  The combined measurement of CA125, CA19-9, and the NLR provided an efficient method for the diagnosis of MCT with torsion.
authors.affiliation: Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Yuan-Qiu
authors.initials: YQ
authors.lastname: Wang
authors.affiliation: Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Wei-Ting
authors.initials: WT
authors.lastname: Xia
authors.affiliation: Department of Pathology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Wenzhou Medical University, Wenzhou, China.
authors.forename: Xin-Xin
authors.initials: XX
authors.lastname: Zhuang
authors.affiliation: Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Fei-Yun
authors.initials: FY
authors.lastname: Zheng
authors.affiliation: Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000276:immunology; D018394:CA-125 Antigen / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D012189:Retrospective Studies; D013724:Teratoma / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D014102:Torsion Abnormality / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen
keywords: Cancer antigen 125; Cancer antigen 19-9; Mature cystic teratoma; Neutrophil-to-lymphocyte ratio; Torsion