title: Long-term follow-up of papillary and follicular thyroid carcinomas with bone metastasis.
abstract: The aims of this study were to investigate papillary and follicular thyroid carcinomas with bone metastasis in various clinical presentations and to determine the prognostic factors after multimodality treatment. A retrospective analysis was performed of 3,120 patients with papillary and follicular thyroid carcinoma. Of these patients, 131 (including 97 women, 71.8%) were diagnosed with bone metastasis and underwent follow-up at the Chang Gung Medical Center. Patients with bone metastasis were categorized into two groups. Group A was comprised of patients who were diagnosed with bone metastasis either before thyroidectomy or within 6 months of the initial thyroidectomy (90 patients, 68.7%). Group B was comprised of patients with bone metastasis who received a diagnosis 6 months post-thyroidectomy in the follow-up period (41 patients, 31.3%). After a mean follow-up period of 8.4 ± 7.0 years, there were 88 deaths (67.2%) attributed to thyroid cancer and 13 patients (9.9%) achieved disease-free status. A multivariate analysis showed that older age, early diagnosis, and brain metastasis were each associated with a poor prognosis. The difference in disease-specific mortality rates between groups A and B was significant (p < 0.0001). In conclusion, papillary and follicular thyroid cancers with bone metastasis have a high rate of mortality. Despite this high mortality, 9.9% patients still had an excellent response to treatment.
authors.affiliation: Division of Endocrinology and Metabolism, Departments of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan County, Taiwan, R.O.C.
authors.forename: Jen-Der
authors.identifier: http://orcid.org/0000-0003-2864-8135
authors.initials: JD
authors.lastname: Lin
authors.affiliation: Division of Endocrinology and Metabolism, Departments of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan County, Taiwan, R.O.C.
authors.forename: Shu-Fu
authors.initials: SF
authors.lastname: Lin
authors.affiliation: Division of Endocrinology and Metabolism, Departments of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan County, Taiwan, R.O.C.
authors.forename: Szu-Tah
authors.initials: ST
authors.lastname: Chen
authors.affiliation: Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan County, Taiwan, R.O.C.
authors.forename: Chuen
authors.initials: C
authors.lastname: Hsueh
authors.affiliation: Healthy Aging Research Center, Chang Gung University, Taoyuan County, Taiwan, R.O.C.
authors.forename: Chia-Lin
authors.initials: CL
authors.lastname: Li
authors.affiliation: Department of General Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan County, Taiwan, R.O.C.
authors.forename: Tzu-Chieh
authors.initials: TC
authors.lastname: Chao
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000556:secondary*; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D055815:Young Adult