title: Gallium-68 Prostate-Specific Membrane Antigen PET Imaging.
abstract: The role of gallium-68 (68Ga) prostate-specific membrane antigen (PSMA) PET imaging is evolving and finding its place in the imaging armamentarium for prostate cancer (PCa). Despite the progress of conventional imaging strategies, significant limitations remain, including identification of small-volume disease and assessment of bone. Clinical studies have demonstrated that68Ga-PSMA is a promising tracer for detection of PCa metastases, even in patients with low prostate-specific antigen. To provide an accurate interpretation of68Ga-PSMA PET/computed tomography, nuclear medicine specialists and radiologists should be familiar with physiologic68Ga-PSMA uptake, common variants, patterns of locoregional and distant spread of PCa, and inherent pitfalls.
authors.affiliation: Department of Cancer Imaging, Centre for Molecular Imaging, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia; University of Melbourne, Melbourne, Victoria 3000, Australia. Electronic address: Michael.hofman@petermac.org.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Hofman
authors.affiliation: Department of Cancer Imaging, Centre for Molecular Imaging, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia.
authors.forename: Amir
authors.initials: A
authors.lastname: Iravani
mesh_terms: D000954:Antigens, Surface / Q000378:metabolism*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D005710:Gallium Radioisotopes; D043425:Glutamate Carboxypeptidase II / Q000378:metabolism*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D014781:Viscera / Q000000981:diagnostic imaging
chemical_list: D000954:Antigens, Surface; D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II
keywords: (68)Ga-PSMA; (68)Ga-PSMA PET; PET; Prostate cancer; Prostate-specific membrane antigen