title: Enhanced Expression of Serotonin Receptor 5-Hydroxytryptamine 2C is Associated with Increased Feather Damage in Dongxiang Blue-Shelled Layers.
abstract: The gene encoding the serotonin receptor 5-hydroxytraptamine 2C (HTR2C) has been implicated in behavioral phenotypes in a number of species. In previous studies, a mutation in the chicken HTR2C gene was found to be associated with feather condition, thereby suggesting a relationship between the gene and receiving feather pecking activity. The present study analyzed the chicken HTR2C gene at both the genomic make-up and expression level in Dongxiang blue-shelled layer. A significant association between the single nucleotide polymorphism (SNP) rs13640917 (C/T) and feather condition was confirmed in the Chinese local layer. Enhanced HTR2C gene expression (151.1-fold) that was associated with high feather damage indicated that the right cerebrum might be the critical region for HTR2C to participate in the regulation of receiving feather pecking behavior.
authors.affiliation: Shanghai Academy of Agricultural Sciences, No. 2901 Beidi road, Minghang Qu, Shanghai, 201106, China.|National Poultry Engineer Research Center, Shanghai, China.
authors.forename: Junfeng
authors.identifier: 0000-0002-5247-5476
authors.initials: J
authors.lastname: Yao
authors.affiliation: Shanghai Academy of Agricultural Sciences, No. 2901 Beidi road, Minghang Qu, Shanghai, 201106, China.|National Poultry Engineer Research Center, Shanghai, China.
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Shanghai Academy of Agricultural Sciences, No. 2901 Beidi road, Minghang Qu, Shanghai, 201106, China.|National Poultry Engineer Research Center, Shanghai, China.
authors.forename: Huangxiang
authors.initials: H
authors.lastname: Yan
authors.affiliation: Shanghai Academy of Agricultural Sciences, No. 2901 Beidi road, Minghang Qu, Shanghai, 201106, China.|National Poultry Engineer Research Center, Shanghai, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Cai
authors.affiliation: National Poultry Engineer Research Center, Shanghai, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: National Poultry Engineer Research Center, Shanghai, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Tu
authors.affiliation: Shanghai Academy of Agricultural Sciences, No. 2901 Beidi road, Minghang Qu, Shanghai, 201106, China. yaobison1983@163.com.|National Poultry Engineer Research Center, Shanghai, China. yaobison1983@163.com.
authors.forename: Changsuo
authors.initials: C
authors.lastname: Yang
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002645:Chickens / Q000235:genetics*; D005241:Feathers; D020641:Polymorphism, Single Nucleotide; D044405:Receptor, Serotonin, 5-HT2C / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D044405:Receptor, Serotonin, 5-HT2C
keywords: Chicken HTR2C; Feather condition; Gene expression; Receiving feather pecking; SNPs