title: Exercise-induced albuminuriavscircadian variations in blood pressure in type 1 diabetes.
abstract: OBJECTIVE
  To investigated the relationship between exercise-induced ambulatory blood pressure measurement (ABPM) abnormalities in type 1 diabetes mellitus (T1DM) adolescents.
  
  
  METHODS
  We conducted a case-control at the National Obesity Center of the Yaoundé Central Hospital, Cameroon. We compared 24 h ABPM and urinary albumin-to-creatinine ratio (ACR) at rest and after a standardized treadmill exercise between 20 Cameroonian T1DM patients and 20 matched controls. T1DM adolescents were aged 12-18 years, with diabetes for at least one year, without proteinuria, with normal office blood pressure (BP) and renal function according to the general reference population. Non-diabetic controls were adolescents of general population matched for sex, age and BMI.
  
  
  RESULTS
  Mean duration of diabetes was 4.2 ± 2.8 years. The mean 24 h systolic blood pressure (SBP) and diastolic blood pressure (DBP) were respectively 116 ± 9 mmHg in the diabetic groupvs111 ± 8 mmHg in the non-diabetic (P= 0.06), and 69 ± 7 mm Hgvs66 ± 5 mm Hg (P= 0.19). There was no difference in the diurnal pattern of BP in diabetes patients and non-diabetic controls (SBP: 118 ± 10 mmHgvs114 ± 10 mmHg,P= 0.11; DBP: 71 ± 7 mmHgvs68 ± 6 mmHg,P= 0.22). Nighttime BP was higher in the diabetic group with respect to SBP (112 ± 11 mmHgvs106 ± 7 mmHg,P= 0.06) and to the mean arterial pressure (MAP) (89 ± 9 mmHgvs81 ± 6 mmHg,P= 0.06). ACR at rest was similar in both groups (5.5 mg/gvs5.5 mg/g,P= 0.74), but significantly higher in diabetes patients after exercise (10.5 mg/gvs5.5 mg/g,P= 0.03). SBP was higher in patients having exercise-induced albuminuria (116 ± 10 mmHgvs108 ± 10 mmHg,P= 0.09).
  
  
  CONCLUSIONS
  Exercise-induced albuminuria could be useful for early diagnosis of kidney damage in adolescents with T1DM.
authors.affiliation: Isabelle Hota Tadida Meli, Institut Supérieur des Sciences de la Santé, Université des Montagnes, 208 Bangangté, Cameroon.
authors.forename: Isabelle Hota
authors.initials: IH
authors.lastname: Tadida Meli
authors.affiliation: Isabelle Hota Tadida Meli, Institut Supérieur des Sciences de la Santé, Université des Montagnes, 208 Bangangté, Cameroon.
authors.forename: Aurel T
authors.initials: AT
authors.lastname: Tankeu
authors.affiliation: Isabelle Hota Tadida Meli, Institut Supérieur des Sciences de la Santé, Université des Montagnes, 208 Bangangté, Cameroon.
authors.forename: Mesmin Y
authors.initials: MY
authors.lastname: Dehayem
authors.affiliation: Isabelle Hota Tadida Meli, Institut Supérieur des Sciences de la Santé, Université des Montagnes, 208 Bangangté, Cameroon.
authors.forename: David
authors.initials: D
authors.lastname: Chelo
authors.affiliation: Isabelle Hota Tadida Meli, Institut Supérieur des Sciences de la Santé, Université des Montagnes, 208 Bangangté, Cameroon.
authors.forename: Jean Jacques N
authors.initials: JJ
authors.lastname: Noubiap
authors.affiliation: Isabelle Hota Tadida Meli, Institut Supérieur des Sciences de la Santé, Université des Montagnes, 208 Bangangté, Cameroon.
authors.forename: Eugene
authors.initials: E
authors.lastname: Sobngwi
keywords: Albuminuria; Ambulatory blood pressure measurement; Blood pressure; Exercise; Type 1 diabetes