title: HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4.
authors.affiliation: Institute for Lung Health, Department of Infection, Immunity & Inflammation, Glenfield Hospital, University of Leicester, Leicester, United Kingdom.
authors.forename: Leonarda
authors.initials: L
authors.lastname: Di Candia
authors.affiliation: Institute for Lung Health, Department of Infection, Immunity & Inflammation, Glenfield Hospital, University of Leicester, Leicester, United Kingdom.
authors.forename: Edith
authors.initials: E
authors.lastname: Gomez
authors.affiliation: San Raffaele University and Scientific Institute and HMGBiotech s.r.l., Milan, Italy.
authors.forename: Emilie
authors.initials: E
authors.lastname: Venereau
authors.affiliation: Institute for Lung Health, Department of Infection, Immunity & Inflammation, Glenfield Hospital, University of Leicester, Leicester, United Kingdom.
authors.forename: Latifa
authors.initials: L
authors.lastname: Chachi
authors.affiliation: Institute for Lung Health, Department of Infection, Immunity & Inflammation, Glenfield Hospital, University of Leicester, Leicester, United Kingdom.
authors.forename: Davinder
authors.initials: D
authors.lastname: Kaur
authors.affiliation: San Raffaele University and Scientific Institute and HMGBiotech s.r.l., Milan, Italy.
authors.forename: Marco E
authors.initials: ME
authors.lastname: Bianchi
authors.affiliation: Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
authors.forename: R A John
authors.initials: RAJ
authors.lastname: Challiss
authors.affiliation: Institute for Lung Health, Department of Infection, Immunity & Inflammation, Glenfield Hospital, University of Leicester, Leicester, United Kingdom.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Brightling
authors.affiliation: Institute for Lung Health, Department of Infection, Immunity & Inflammation, Glenfield Hospital, University of Leicester, Leicester, United Kingdom. Electronic address: rms4@le.ac.uk.
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Saunders
mesh_terms: D001249:Asthma / Q000235:genetics / Q000378:metabolism*; D015415:Biomarkers; D004797:Enzyme-Linked Immunosorbent Assay; D015870:Gene Expression; D024243:HMGB1 Protein / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000378:metabolism*; D012137:Respiratory System / Q000378:metabolism*; D013183:Sputum / Q000378:metabolism; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D024243:HMGB1 Protein; C585491:HMGB1 protein, human; D051197:Toll-Like Receptor 4