title: [Atrial fibrillation in patients with obstructive hypertrophic cardiomyopathy: clinical characteristics and risk factors].
abstract: Objective:To evaluate the clinical characteristics and risk factors for atrial fibrillation(AF)in patients with obstructive hypertrophic cardiomyopathy(OHCM).Methods:Patients with OHCM hospitalized in Fuwai Hospital from March 2011 to January 2016 were enrolled in the present study. Each patient underwent examinations including transthoracic echocardiography, body surface electrocardiograph or dynamic electrocardiogram (Holter). Cardiac troponin I (cTNI) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP)levels were tested and clinical profiles were collected.The subjects were divided into two groups (the AF group and non-AF group). Risk factors for AF in patients with OHCM were assessed by multivariate logistic regression analysis.Results:A total of 309 patients were evaluated in the study. Among them, 17.5%( 54/309) patients were with AF.Age[(51.2±10.1)years vs (43.1 ± 14.4)years], New York Heart Association class(NYHA class)(2.8±0.5 vs 2.6±0.6), disease duration[6.0(4.0, 10.0)years vs 3.0(1.0, 6.0)years], left atrial (LA) dimension[(45.1±7.0)mm vs(42.6 ± 7.4)mm]and NT-pro-BNP levels[2 007(1 565, 3 199)pmol/L vs 1 509(729, 2 921)pmol/L]in the AF group were significantly higher than those in the non-AF group (allP<0.05). Multivariate logistic regression analysis indicated that advanced age(OR=1.04, 95%CI1.01-1.08,P<0.01), higher NYHA class(OR=2.00, 95%CI1.08-3.70,P<0.05)and longer disease duration(OR=1.08, 95%CI1.01-1.15,P<0.05)were independent risk factors for AF in patients with OHCM, in which advanced age(OR=1.05, 95%CI1.02-1.09,P<0.01), higher NYHA class(OR=3.39, 95%CI1.53-7.54,P<0.01), LA dimension(OR=1.06, 95%CI1.01-1.12,P<0.05)and longer clinical course(OR=1.12, 95%CI1.04-1.20,P<0.01)were associated with AF in male patients, and advanced age (OR=1.05, 95%CI1.01-1.09,P<0.05)and longer disease duration(OR=1.14, 95%CI1.01-1.28,P<0.01)were associated with AF in female patients when stratified by gender.Conclusion:Advanced age , higher NYHA class and longer clinical duration are independent risk factors for AF in OHCM patients.
authors.forename: X
authors.initials: X
authors.lastname: Wu
authors.forename: H
authors.initials: H
authors.lastname: Cui
authors.forename: J J
authors.initials: JJ
authors.lastname: Wang
authors.forename: M H
authors.initials: MH
authors.lastname: Xiao
authors.forename: J
authors.initials: J
authors.lastname: Lu
authors.forename: X X
authors.initials: XX
authors.lastname: Zheng
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.forename: S Y
authors.initials: SY
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China.
authors.forename: X H
authors.initials: XH
authors.lastname: Huang
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood*; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood*; D002318:Cardiovascular Diseases; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012307:Risk Factors
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Atrial fibrillation; New York Heart Association class; Obstructive hypertrophic cardiomyopathy