title: DAI Another Way: Necroptotic Control of Viral Infection.
abstract: Interrogation of murine cytomegalovirus (MCMV)-encoded cell-death suppressors revealed that necroptosis functions as a trap door to eliminate virally infected cells. This crucial host defense pathway is orchestrated by the sensing of infection by DAI/ZBP-1, engagement of the kinase RIPK3, and subsequent membrane permeablization by the pseudokinase MLKL.
authors.affiliation: Department of Molecular Biosciences, LaMontagne Center for Infectious Disease, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. Electronic address: upton@austin.utexas.edu.
authors.forename: Jason W
authors.initials: JW
authors.lastname: Upton
authors.affiliation: Department of Microbiology, Immunology, & Molecular Genetics, University of Texas Health Sciences Center at San Antonio, San Antonio, TX 78229, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Kaiser
mesh_terms: D000818:Animals; D016923:Cell Death; D003587:Cytomegalovirus / Q000254:growth & development*; D003586:Cytomegalovirus Infections / Q000276:immunology*; D006023:Glycoproteins / Q000378:metabolism*; D051379:Mice; D016601:RNA-Binding Proteins; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D006023:Glycoproteins; D016601:RNA-Binding Proteins; C402632:Zbp1 protein, mouse; D053422:Receptor-Interacting Protein Serine-Threonine Kinases; C485615:Ripk3 protein, mouse