title: [Abdominal pain syndrome and quality of life in patients with cholelithiasis after cholecystectomy during a 10-year follow-up].
abstract: OBJECTIVE
  To estimate the incidence of abdominal pain syndrome (APS) and to assess quality of life (QOL) in patients within 10 years after cholecystectomy (CE).
  
  
  METHODS
  This investigation is part of a long-term prospective follow-up study of patients after CE for cholelithiasis (CL). It enrolled 145 people: 30 (21.5%) patients with baseline asymptomatic CL and 115 (80.7%) with its clinical manifestations. The time course of changes in APS and QOL were analyzed.
  
  
  RESULTS
  Over 10 years, all the patients showed a decrease in the incidence of APS from 84.1% (n=95) to 66.4% (n=75; p=0.004). In Group 1 (n=89), APS was at baseline detected in all the patients; 10 years later, its incidence declined to 67.4% (n=60; p < 0.001). Biliary pains were predominant; these had been identified significantly less frequently over the 10-year period in 47 (52.8%) patients; p<0.001). In Group 2 (n=24), pre-CE APS was generally detected in 6 (25%) patients; following 10 years, the incidence rates of pain significantly increased to 62.5% (n=15; p=0.035), among which there were predominant biliary pains (in 54.2%; p<0.001) and dyspepsia from 33.3% (n=8) up to 66.7% (n=16; p=0.039). QOL in the physical and mental health domains was found to decrease in both groups.
  
  
  CONCLUSIONS
  Ten years after CE, the group with the baseline clinical manifestations of CL and poorer QOL showed a lower incidence of APS mainly due to the reduced incidence of biliary pains and the baseline asymptomatic group exhibited a rise in the incidence of APS due to the appearance of biliary pains and dyspepsia.
authors.affiliation: Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Makarova
authors.affiliation: Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Litvinova
authors.affiliation: Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia.
authors.forename: M F
authors.initials: MF
authors.lastname: Osipenko
authors.affiliation: Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia.
authors.forename: N B
authors.initials: NB
authors.lastname: Voloshina
mesh_terms: D015746:Abdominal Pain / Q000209:etiology*; D000368:Aged; D002763:Cholecystectomy / Q000009:adverse effects* / Q000706:statistics & numerical data; D002769:Cholelithiasis / Q000601:surgery*; D004415:Dyspepsia / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D011788:Quality of Life