title: Role of Vitamin D in Intima Media Thickness in Patients with Type 1 Diabetes Mellitus.
abstract: Increased carotid intima media thickness indicates subclinical atherosclerosis. We evaluated the relation between vitamin D level and intima media thickness in patients with type 1 DM. 93 patients (female/male: 48/45, aged 31.5 ± 11.9 years, A1c 9.48 ± 2.43, vitamin D [15.9 (12.1-19.2)]) with type 1 DM were included into the study. Common carotid artery IMT was measured by real time B mode ultrasonography (MyLab 70 XVG, Esaote SpA, Genoa, Italy). Vitamin D was measured using radioimmunassay. Male and female patients (n = 14, 15%) had similar rates of plaque presence (p = 0.377). IMT was similar according to gender. IMT [0.45 (0.40-0.50)] was positively correlated with age, duration of diabetes, creatinine, LDL/HDL ratio, and ALP. Median IMT was higher in current smokers, patients with retinopathy, and nephropathy, and overweight/obese patients. IMT was not different according to vitamin D status. However calcium level corrected for albumin was in positive correlation with mean IMT (r = 0.221, p = 0.033). We detected high frequency of vitamin D deficiency (78%) defined as less than 20 ng/ml. Vitamin D and diabetes control defined as A1c have no effect on intima media thickness in type 1 DM. Traditional cardiovascular risk factors including age, duration of DM, smoking, and BMI adversely affect intima media thickness.
authors.affiliation: Department of Endocrinology, Yunus Emre State Hospital, Eskisehir, Turkey. Electronic address: bengurtaskiran@yahoo.com.tr.
authors.forename: Bengur
authors.initials: B
authors.lastname: Taskiran
authors.affiliation: Department of Endocrinology, Yunus Emre State Hospital, Eskisehir, Turkey.
authors.forename: Guven B
authors.initials: GB
authors.lastname: Cansu
authors.affiliation: Department of Radiology, Yunus Emre State Hospital, Eskisehir, Turkey.
authors.forename: Eylem
authors.initials: E
authors.lastname: Bahadir
authors.affiliation: Department of Nephrology, Yunus Emre State Hospital, Eskisehir, Turkey.
authors.forename: Ruya
authors.initials: R
authors.lastname: Mutluay
mesh_terms: D000328:Adult; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness / Q000706:statistics & numerical data*; D000078331:Correlation of Data; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000175:diagnosis / Q000453:epidemiology
chemical_list: D014807:Vitamin D
keywords: Intima media thickness; Type 1 diabetes mellitus; Vitamin D