title: Concurrent autoimmune hepatitis in multiple sclerosis.
abstract: Autoimmune hepatitis (AIH) is a rare and chronic inflammatory disorder associated with extrahepatic autoimmune diseases, including, infrequently, multiple sclerosis (MS). Short Reports: We report five cases of MS and AIH association. One patient developed AIH while under interferon beta-1b and the remaining while off disease-modifying therapy, although after methylprednisolone bolus in three. All presented a liver biopsy compatible with AIH. Hepatitis resolution was achieved with immunosuppressive treatment, but one patient died after a fulminant hepatitis requiring liver transplant.
  
  
  
  A thorough review of published cases supports this clear, although rare, association and a liver biopsy should be considered in AIH suspected cases.
authors.affiliation: Serviço de Neurologia, Centro Hospitalar do Porto, Hospital de Santo António, Porto, Portugal.
authors.forename: Gonçalo
authors.initials: G
authors.lastname: Cação
authors.affiliation: Servico de Neurologia, Centro Hospitalar do Porto, Hospital de Santo António, Porto, Portugal/Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
authors.forename: Ernestina
authors.initials: E
authors.lastname: Santos
authors.affiliation: Servico de Neurologia, Centro Hospitalar do Porto, Hospital de Santo António, Porto, Portugal/Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Martins Silva
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis* / Q000453:epidemiology
keywords: Multiple sclerosis; autoimmune hepatitis; disease-modifying therapy; high-dose intravenous steroids; liver biopsy