title: A new hexahydrobenzopyran derivative from the gorgonian-derived Fungus Eutypella sp.
abstract: A new hexahydrobenzopyran derivative cytosporin L (1), and another eight known compounds were isolated from the gorgonian-derived fungus Eutypella sp. collected from the South China Sea. The structure of 1 was elucidated by comprehensive spectroscopic data. The absolute configuration of 1 was determined by a chemical reaction and the modified Mosher's method. The isolated secondary metabolites were evaluated for their antibacterial activities. Compound 1 showed antibacterial activity towards Micrococcus lysodeikticus and Enterobacter aerogenes with the same MIC values of 3.12 μM. Compounds 1-3 were evaluated for antiviral activities. Compounds 1 and 2 obviously inhibited the respiratory syncytial virus (RSV) with the IC50values of 72.01 and 30.25 μM, respectively.
authors.affiliation: a Key Laboratory of Marine Drugs , The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao , People's Republic of China.|b Laboratory for Marine Drugs and Bioproducts , Qingdao National Laboratory for Marine Science and Technology , Qingdao , People's Republic of China.
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Liao
authors.affiliation: a Key Laboratory of Marine Drugs , The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao , People's Republic of China.|b Laboratory for Marine Drugs and Bioproducts , Qingdao National Laboratory for Marine Science and Technology , Qingdao , People's Republic of China.
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Sun
authors.affiliation: c Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , People's Republic of China.
authors.forename: Cai-Juan
authors.initials: CJ
authors.lastname: Zheng
authors.affiliation: a Key Laboratory of Marine Drugs , The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao , People's Republic of China.|b Laboratory for Marine Drugs and Bioproducts , Qingdao National Laboratory for Marine Science and Technology , Qingdao , People's Republic of China.
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology; D001578:Benzopyrans / Q000302:isolation & purification*; D002681:China; D005658:Fungi / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D001578:Benzopyrans
keywords: Eutypella sp; Gorgonian-derived fungus; bioactivity; hexahydrobenzopyran; structure elucidation