title: Clinical Results of Cardiac Surgery in Patients with Chronic Hepatitis C and Their Role in Risk Models: A Case-Control Study.
abstract: To evaluate the results of patients with chronic hepatitis C virus (HCV) following cardiac surgery in the TurcoSCORE (TrS) database.
  
  
  
  Sixty patients with HCV who underwent cardiac surgery between 2005 and 2016 in our clinic out of a total 8,018 patients from the TrS database were included in the study. The perioperative morbidity and mortality rates in these patients were compared with a matched cohort.
  
  
  
  The mean follow-up time was 96.6 ± 12.3 months. Hospital mortality rates (HCV group 5% vs. control group 1.7%,p= 0.61) were similar between the groups. No significant difference was found in the duration of cardiopulmonary bypass (HCV 79.1 ± 12.3 vs. control 82.6 ± 11.8,p= 0.88) and cross clamps (HCV 33.4 ± 6.9 vs control 33.8 ± 7.2p= 0.76) between the two groups. The rate of patients who were revised due to postoperative hemorrhage was significantly higher in the HCV arm compared with the matched cohort (HCV 13.3% vs. control 1.7%,p< 0.05). Although the measured prothrombin time (PT) and international normalized ratio (INR) in the postoperative 24th hour were in normal ranges in both arms, they were significantly higher in the HCV arm (HCV 11.2 ± 1.2 vs. control 10.5 ± 0.8,p< 0.05; HCV 0.99 ± 0.06, vs. control 0.92 ± 0.03,p< 0.0001).
  
  
  
  The presence of HCV can be an important prognostic factor for morbidity in patients undergoing cardiac surgery. It can also play an important role in the risk models generated for cardiac surgery.
authors.affiliation: Department of Cardiovascular Surgery, Ankara University, Cebeci Heart Center, Ankara, Turkey.
authors.forename: Cagdas
authors.initials: C
authors.lastname: Baran
authors.affiliation: Department of Cardiovascular Surgery, Ankara University, Cebeci Heart Center, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Cakici
authors.affiliation: Department of Cardiovascular Surgery, Ankara University, Cebeci Heart Center, Ankara, Turkey.
authors.forename: Evren
authors.initials: E
authors.lastname: Ozcinar
authors.affiliation: Department of Cardiovascular Surgery, Ankara University, Cebeci Heart Center, Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Durdu
authors.affiliation: Department of Cardiovascular Surgery, Ankara University, Cebeci Heart Center, Ankara, Turkey.
authors.forename: Bahadir
authors.initials: B
authors.lastname: Inan
authors.affiliation: Department of Cardiovascular Surgery, Ankara University, Cebeci Heart Center, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sirlak
authors.affiliation: Department of Cardiovascular Surgery, Ankara University, Cebeci Heart Center, Ankara, Turkey.
authors.forename: Ruchan
authors.initials: R
authors.lastname: Akar
mesh_terms: D000368:Aged; D001777:Blood Coagulation; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000401:mortality; D016022:Case-Control Studies; D000066491:Clinical Decision-Making; D016208:Databases, Factual; D003661:Decision Support Techniques; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000150:complications / Q000401:mortality / Q000601:surgery*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D006801:Humans; D019934:International Normalized Ratio; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000401:mortality / Q000628:therapy; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011517:Prothrombin Time; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014421:Turkey