title: Transcription factor 7-like 2 (TCF7L2) gene polymorphisms are strong predictorsof type 2 diabetes among nonobese diabetics in the Turkish population.
abstract: Type 2 diabetes (T2D) is1397645907a multifactorial disease, determined by environmental and genetic factors. Currently, the transcription factor 7-like 2 (TCF7L2) gene shows the strongest association with T2D. In this study, we investigated whether TCF7L2 gene polymorphisms are associated with T2D in a Turkish population.
  
  
  
  Using PCR-RFLP and PCR-SSCP, we genotyped six intronic polymorphisms in the TCF7L2 gene, commonly associated with T2D, in 169 individuals with diabetes and 119 healthy controls.
  
  
  
  We found that rs7903146 C → T substitution in intron 3 (OR: 1.9, P = 0.005) and rs12255372 G → T substitution in intron 4 (OR: 2.1, P = 0.002) were significantly associated with T2D while other SNPs were not associated (P > 0.05). We determined no association between TCF7L2 gene polymorphisms and fasting glucose, fasting insulin, HbA1c, or HOMA-IR levels (P > 0.05), except for rs7903146 C → T substitution, which was significantly associated with the fasting glucose level (P = 0.003).
  
  
  
  Our results indicate that, in the Turkish population, the T allele of the rs7903146 (C → T) and rs12255372 (G → T) polymorphisms in the TCF7L2 gene is an independent risk factor for the development of T2D.
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Selçuk University, Konya, Turkey.
authors.forename: Dudu
authors.initials: D
authors.lastname: Erkoç Kaya
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Selçuk University, Konya, Turkey.
authors.forename: Hilal
authors.initials: H
authors.lastname: Arikoğlu
authors.affiliation: Department of Medical Informatics and Biostatistics, Karabük University, Karabük, Turkey.
authors.forename: Seyit Ali
authors.initials: SA
authors.lastname: Kayiş
authors.affiliation: Department of Biophysics, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Öztürk
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Faculty of Medicine, İstanbul Bilim University, İstanbul, Turkey.
authors.forename: Mustafa Sait
authors.initials: MS
authors.lastname: Gönen
mesh_terms: D001835:Body Weight / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*; D014421:Turkey / Q000453:epidemiology
chemical_list: D058118:Transcription Factor 7-Like 2 Protein