title: Sigma-1 Receptor and Neuronal Excitability.
abstract: The sigma-1 receptor (Sig-1R), via interaction with various proteins, including voltage-gated and ligand-gated ion channels (VGICs and LGICs), is involved in a plethora of neuronal functions. This capability to regulate a variety of ion channel targets endows the Sig-1R with a powerful capability to fine tune neuronal excitability, and thereby the transmission of information within brain circuits. This versatility may also explain why the Sig-1R is associated to numerous diseases at both peripheral and central levels. To date, how the Sig-1R chooses its targets and how the combinations of target modulations alter overall neuronal excitability is one of the challenges in the field of Sig-1R-dependent regulation of neuronal activity. Here, we will describe and discuss the latest findings on Sig-1R-dependent modulation of VGICs and LGICs, and provide hypotheses that may explain the diverse excitability outcomes that have been reported so far.
authors.affiliation: Department of Psychiatry, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, TX, 75390-9070, USA. Said.Kourrich@UTSouthwestern.edu.
authors.forename: Saïd
authors.initials: S
authors.lastname: Kourrich
mesh_terms: D000200:Action Potentials; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D054351:Electrical Synapses / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D058446:Ligand-Gated Ion Channels / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D024642:Potassium Channels, Voltage-Gated / Q000378:metabolism; D017480:Receptors, sigma / Q000378:metabolism*; D009435:Synaptic Transmission; D061566:Voltage-Gated Sodium Channels / Q000378:metabolism; D000097605:Sigma-1 Receptor
chemical_list: D015220:Calcium Channels; D058446:Ligand-Gated Ion Channels; D024642:Potassium Channels, Voltage-Gated; D017480:Receptors, sigma; D061566:Voltage-Gated Sodium Channels; D000097605:Sigma-1 Receptor
keywords: AMPA receptor; Auxiliary subunit; Calcium channels; Chaperone protein; Intrinsic excitability; NMDA receptor; Potassium channels; Sigma-1 receptor; Sodium channels; Voltage-gated ion channels