title: Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI.
abstract: Hyperpolarised3He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6-16 years) with clinically stable mild cystic fibrosis (CF) (FEV1>-1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, compared with CT abnormalities in 68%, LCI 47% and conventional MRI 22%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI. Ventilation-MRI is thus feasible in young children, highly sensitive and provides additional information about lung structure-function relationships.
authors.affiliation: POLARIS, Academic Radiology, University of Sheffield, Sheffield, UK.
authors.forename: Helen
authors.initials: H
authors.lastname: Marshall
authors.affiliation: POLARIS, Academic Radiology, University of Sheffield, Sheffield, UK.|Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.
authors.forename: Alex
authors.initials: A
authors.lastname: Horsley
authors.affiliation: Sheffield Children's Hospital, Sheffield, UK.
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Taylor
authors.affiliation: POLARIS, Academic Radiology, University of Sheffield, Sheffield, UK.|Sheffield Children's Hospital, Sheffield, UK.
authors.forename: Laurie
authors.initials: L
authors.lastname: Smith
authors.affiliation: Sheffield Children's Hospital, Sheffield, UK.
authors.forename: David
authors.initials: D
authors.lastname: Hughes
authors.affiliation: POLARIS, Academic Radiology, University of Sheffield, Sheffield, UK.
authors.forename: Felix C
authors.initials: FC
authors.lastname: Horn
authors.affiliation: POLARIS, Academic Radiology, University of Sheffield, Sheffield, UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Swift
authors.affiliation: POLARIS, Academic Radiology, University of Sheffield, Sheffield, UK.
authors.forename: Juan
authors.initials: J
authors.lastname: Parra-Robles
authors.affiliation: POLARIS, Academic Radiology, University of Sheffield, Sheffield, UK.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Hughes
authors.affiliation: POLARIS, Academic Radiology, University of Sheffield, Sheffield, UK.
authors.forename: Graham
authors.initials: G
authors.lastname: Norquay
authors.affiliation: POLARIS, Academic Radiology, University of Sheffield, Sheffield, UK.
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Stewart
authors.affiliation: POLARIS, Academic Radiology, University of Sheffield, Sheffield, UK.
authors.forename: Guilhem J
authors.initials: GJ
authors.lastname: Collier
authors.affiliation: School of Health and Related Research, University of Sheffield, Sheffield, UK.
authors.forename: Dawn
authors.initials: D
authors.lastname: Teare
authors.affiliation: Department of Respiratory and Sleep Medicine, Royal Hospital for Sick Children, Edinburgh, UK.
authors.forename: Steve
authors.initials: S
authors.lastname: Cunningham
authors.affiliation: Sheffield Children's Hospital, Sheffield, UK.
authors.forename: Ina
authors.initials: I
authors.lastname: Aldag
authors.affiliation: POLARIS, Academic Radiology, University of Sheffield, Sheffield, UK.
authors.forename: Jim M
authors.initials: JM
authors.lastname: Wild
mesh_terms: D000293:Adolescent; D002648:Child; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000503:physiopathology; D042241:Early Diagnosis; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012121:Respiration, Artificial / Q000379:methods*; D013147:Spirometry / Q000379:methods; D014057:Tomography, X-Ray Computed
keywords: Cystic Fibrosis; Imaging/CT MRI etc; Respiratory Measurement