title: Forecasting Fat Fibrosis.
abstract: Excess ECM and fibrosis of white adipose tissue (WAT) is associated with tissue dysfunction and type 2 diabetes. In this issue of Cell Metabolism, Marcelin et al. (2017) elucidate a key mechanism behind WAT fibrosis in which the activation of PDGFRα on adipocyte precursors drives this population toward a fibrotic phenotype.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.
authors.forename: Brett
authors.initials: B
authors.lastname: Shook
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA; Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: matthew.rodeheffer@yale.edu.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Rodeheffer
mesh_terms: D017667:Adipocytes / Q000166:cytology; D052436:Adipose Tissue, White / Q000166:cytology*; D003924:Diabetes Mellitus, Type 2; D005355:Fibrosis; D006801:Humans; D010641:Phenotype