title: Comparison of Electrocardiography Markers and Speckle Tracking Echocardiography for Assessment of Left Ventricular Myocardial Scar Burden in Patients With Previous Myocardial Infarction.
abstract: Myocardial scar burden is an important prognostic factor after myocardial infarction. This cohort study compared assessment of left ventricle scar burden between pathological Q waves on electrocardiography (ECG), Selvester multiparametric ECG scoring system for scar burden, and global longitudinal strain (GLS) by speckle-tracking echocardiography 6 months after myocardial infarction. The scar burden was defined by late gadolinium enhancement cardiac magnetic resonance as fraction of total left ventricle tissue. ECG measures were presence of pathologic Q waves and Selvester scores. GLS was the average of peak strain from 16 left ventricle segments. In 34 patients aged 58 ± 10 years (mean ± SD), the scar burden was 19% (9, 26) (median [quartiles]) and 79% had scar burden >5%. Patients with scar burden >5% more frequently had pathologic Q waves (63% vs 14%) and had worse Selvester scores (5 [3, 7] vs 0 [0, 1]) and worse GLS (-16.6 ± 2.4% vs -19.9 ± 1.1%). Pathologic Q waves, Selvester scores, ejection fraction, and GLS related to scar burden in univariable analyses. Sensitivity and specificity for detecting scar burden >5% was 63% and 86% (pathologic Q waves), 89% and 86% (Selvester score), 81% and 86% (ejection fraction), 89% and 86% (GLS), and 96% and 71% (combination of Q waves, Selvester score, and GLS). In conclusion, Selvester score and GLS related to scars 6 months after myocardial infarction, and pathologic Q waves were only weakly associated with scar and GLS was associated with scar independently of ECG markers.
authors.affiliation: Department of Cardiology and Center for Cardiological Innovation, Oslo University Hospital, Oslo, Norway; Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Eirik
authors.initials: E
authors.lastname: Nestaas
authors.affiliation: Department of Cardiology and Center for Cardiological Innovation, Oslo University Hospital, Oslo, Norway; Division of Cardiology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Jhih-Yuan
authors.initials: JY
authors.lastname: Shih
authors.affiliation: Department of Cardiology and Center for Cardiological Innovation, Oslo University Hospital, Oslo, Norway.
authors.forename: Marit K
authors.initials: MK
authors.lastname: Smedsrud
authors.affiliation: Department of Cardiology and Center for Cardiological Innovation, Oslo University Hospital, Oslo, Norway.
authors.forename: Ola
authors.initials: O
authors.lastname: Gjesdal
authors.affiliation: Department of Cardiology and Center for Cardiological Innovation, Oslo University Hospital, Oslo, Norway; Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
authors.forename: Einar
authors.initials: E
authors.lastname: Hopp
authors.affiliation: Department of Cardiology and Center for Cardiological Innovation, Oslo University Hospital, Oslo, Norway; Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Kristina H
authors.initials: KH
authors.lastname: Haugaa
authors.affiliation: Department of Cardiology and Center for Cardiological Innovation, Oslo University Hospital, Oslo, Norway; Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: thor.edvardsen@medisin.uio.no.
authors.forename: Thor
authors.initials: T
authors.lastname: Edvardsen
mesh_terms: D000368:Aged; D002921:Cicatrix / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D015331:Cohort Studies; D003287:Contrast Media; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005682:Gadolinium; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D011379:Prognosis; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D003287:Contrast Media; D005682:Gadolinium