title: MAGE-A family serves as poor prognostic markers and potential therapeutic targets for epithelial ovarian cancer patients: a retrospective clinical study.
abstract: OBJECTIVE
  The aim of our study is to investigate the expression pattern and prognostic significance of melanoma-associated antigens-A (MAGE-A) family in primary epithelial ovarian cancer (EOC) patients.
  
  
  METHODS
  The expression of MAGE-A family members, including MAGE-A1, -A2, -A3, -A4, -A6, -A10 and -A12 was immunohistochemically detected in 82 cases of primary EOC and 10 cases of pericarcinoma ovarian tissues. The association between MAGE-A family expression and the clinicopathological parameters as well as the prognosis of primary EOC patients was analyzed.
  
  
  RESULTS
  MAGE-A family expressed in 48.8% of primary EOC tissues, but not expressed in pericarcinoma ovarian tissues. MAGE-A expression was associated with the pathological types, FIGO stage, and pre-operative serum CA125 level. Overall survival of EOC patients with positive MAGE-A family expression was significantly shorter than those patients with negative MAGE-A expression. Multivariate analysis showed that although MAGE-A family expression can affect the overall survival, it was not an independent prognostic marker for EOC patients.
  
  
  CONCLUSIONS
  Molecular assessment of MAGE-A family members could be helpful to improve the prognostic evaluation and to provide a new potential therapeutic target for primary EOC patients.
authors.affiliation: a Department of Obstetrics and Gynecology , Bethune International Peace Hospital , Shijiazhuang , People's Republic of China.|b Research Center, The Fourth Hospital of Hebei Medical University , Shijiazhuang , People's Republic of China , and.
authors.forename: Meixiang
authors.initials: M
authors.lastname: Sang
authors.affiliation: a Department of Obstetrics and Gynecology , Bethune International Peace Hospital , Shijiazhuang , People's Republic of China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Wu
authors.affiliation: b Research Center, The Fourth Hospital of Hebei Medical University , Shijiazhuang , People's Republic of China , and.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Fan
authors.affiliation: b Research Center, The Fourth Hospital of Hebei Medical University , Shijiazhuang , People's Republic of China , and.
authors.forename: Yishui
authors.initials: Y
authors.lastname: Lian
authors.affiliation: b Research Center, The Fourth Hospital of Hebei Medical University , Shijiazhuang , People's Republic of China , and.|c Department of Regenerative Medicine , Graduate School of Medicine and Pharmaceutical Science, University of Toyama , Toyama , Japan.
authors.forename: Meijie
authors.initials: M
authors.lastname: Sang
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D008297:Male; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D011379:Prognosis; D012189:Retrospective Studies; D013737:Testis / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor
keywords: Epithelial ovarian cancer; MAGE-A; prognosis