title: Genomic heterogeneity of Salmonella enterica serovar Typhimurium bacteriuria from chronic infection.
abstract: We sequenced the genomes of 14 sequential Salmonella enterica serovar Typhimurium isolates obtained over a five year period from a patient with persistent Salmonella bacteriuria. The isolates formed five distinct lineages; two of which co-existed over four years. We inferred that the observed within-patient variation resulted from mutation events.
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.
authors.forename: Sophie
authors.initials: S
authors.lastname: Octavia
authors.affiliation: Centre for Infectious Diseases and Microbiology-Public Health, Institute of Clinical Pathology and Medical Research, Westmead Hospital, New South Wales, Australia.
authors.forename: Qinning
authors.initials: Q
authors.lastname: Wang
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.
authors.forename: Mark M
authors.initials: MM
authors.lastname: Tanaka
authors.affiliation: Centre for Infectious Diseases and Microbiology-Public Health, Institute of Clinical Pathology and Medical Research, Westmead Hospital, New South Wales, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, New South Wales, Australia. Electronic address: vitali.sintchenko@sydney.edu.au.
authors.forename: Vitali
authors.initials: V
authors.lastname: Sintchenko
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia. Electronic address: r.lan@unsw.edu.au.
authors.forename: Ruiting
authors.initials: R
authors.lastname: Lan
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001437:Bacteriuria / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D002908:Chronic Disease; D004269:DNA, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D059645:Mutation Rate; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D012480:Salmonella Infections / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D012486:Salmonella typhimurium / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D065288:Serogroup
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial
keywords: Bacteriuria; Chronic carrier; Genome sequencing; Salmonella enterica serovar Typhimurium (S. Typhimurium); Serial isolates; Single nucleotide polymorphisms (SNPs)