title: [Autism: An early neurodevelopmental disorder].
abstract: With approximately 67 million individuals affected worldwide, autism spectrum disorder (ASD) is the fastest growing neurodevelopmental disorder (United Nations, 2011), with a prevalence estimated to be 1/100. In France ASD affects approximately 600,000 individuals (from childhood to adulthood, half of whom are also mentally retarded), who thus have a major handicap in communication and in adapting to daily life, which leads autism to be recognized as a national public health priority. ASD is a neurodevelopmental disorder that affects several domains (i.e., socio-emotional, language, sensori-motor, executive functioning). These disorders are expressed early in life with an age of onset around 18 months. Despite evidence suggesting a strong genetic link with ASD, the genetic determinant remains unclear. The clinical picture is characterized by impairments in social interaction and communication and the presence of restrictive and repetitive behaviors (DSM-5, ICD-10). However, in addition to these two main dimensions there is significant comorbidity between ASD and other neurodevelopmental disorders such as attention deficit hyperactivity disorder or with genetic and medical conditions. One of the diagnostic features of ASD is its early emergence: symptoms must begin in early childhood for a diagnosis to be given. Due to brain plasticity, early interventions are essential to facilitate clinical improvement. Therefore, general practitioners and pediatricians are on the front line to detect early signs of ASD and to guide both medical explorations and early rehabilitation.
authors.affiliation: UMR Inserm U930, équipe autisme, centre universitaire de pédopsychiatrie, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours cedex 09, France. Electronic address: frederique.brilhault@univ-tours.fr.
authors.forename: F
authors.initials: F
authors.lastname: Bonnet-Brilhault
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000067877:Autism Spectrum Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000523:psychology*; D002648:Child; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D033183:Interdisciplinary Communication; D038801:International Classification of Diseases; D000070516:Intersectoral Collaboration; D065886:Neurodevelopmental Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000523:psychology*; D011379:Prognosis; D055815:Young Adult