title: Phytotoxic, antibacterial, and antioxidant activities of mycotoxins and other metabolites from Trichoderma sp.
abstract: A new natural mycotoxin was isolated from the fermentation broth of Trichoderma sp. Jing-8 and the structure was determined as alternariol 1'-hydroxy-9-methyl ether (1), together with twelve known compounds. The structures were elucidated on the basis of their 1D, 2D NMR spectra and mass spectrometric data. Compounds 1, 8 and 9 indicated inhibitions against germination of the seeds of cabbage with MICs < 3 μg/mL. The compound 1 showed the antibacterial activity against Bacillus subtilis and Staphylococcus aureus with MICs at 64 μg/mL. Compound 1 and 3 showed significant DPPH radical-scavenging activities with IC50at 12 μg/mL, respectively. The OH at C-1' in compound 1 decreased the cytotoxicity of these mycotoxins. A primary structure-activity relationship about the alternariol derivatives was discussed. Compounds 2-7 and 8 were the first time to be isolated from the Trichoderma.
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , China.|b College of Science , Honghe University , Mengzi , China.
authors.forename: Ju-Cheng
authors.initials: JC
authors.lastname: Zhang
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , China.
authors.forename: Guang-Yi
authors.initials: GY
authors.lastname: Chen
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , China.
authors.forename: Xiao-Zhan
authors.initials: XZ
authors.lastname: Li
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , China.
authors.forename: Ming
authors.initials: M
authors.lastname: Hu
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , China.
authors.forename: Bang-Yan
authors.initials: BY
authors.lastname: Wang
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , China.
authors.forename: Bao-Hui
authors.initials: BH
authors.lastname: Ruan
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhou
authors.affiliation: c Yunnan Institute of Microbiology , Yunnan University , Kunming , China.
authors.forename: Li-Xing
authors.initials: LX
authors.lastname: Zhao
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , China.
authors.forename: Zhong-Tao
authors.initials: ZT
authors.lastname: Ding
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , China.
authors.forename: Ya-Bin
authors.initials: YB
authors.lastname: Yang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D001937:Brassica / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods; D018525:Germination / Q000187:drug effects; D006801:Humans; D007783:Lactones / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009183:Mycotoxins / Q000737:chemistry / Q000494:pharmacology*; D012639:Seeds / Q000187:drug effects / Q000502:physiology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014242:Trichoderma / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D007783:Lactones; D009183:Mycotoxins; C005197:alternariol
keywords: DPPH radical-scavenging activity; Trichoderma sp.; antibacterial activity; metabolite; phytotoxicity