title: Two new similar alkaloids from Portulaca oleracea L.
abstract: Two novel alkaloids named oleraciamide A (1) and oleraciamide B (2) were isolated from Portulaca oleracea L., and spectroscopic methods including 1D and 2D nuclear magnetic resonance and high-resolution electrospray ionisation quadrupole-time of flight mass spectrometer spectrometry techniques are employed to determine their structures. Oleraciamide A (1) was evaluated no cytotoxicity at concentrations up to 80 μM over 72 h against human adipose-derived stem cells (hADSCs) by CCK-8 method.
authors.affiliation: a School of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , People's Republic of China.
authors.forename: Cuiyu
authors.initials: C
authors.lastname: Li
authors.affiliation: b School of The First Clinic , Liaoning University of Traditional Chinese Medicine , Shenyang , People's Republic of China.
authors.forename: Zheming
authors.initials: Z
authors.lastname: Ying
authors.affiliation: c Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian , People's Republic of China.
authors.forename: Mingzhe
authors.initials: M
authors.lastname: Gao
authors.affiliation: d Regenerative Medicine Center , The First Affiliated Hospital of Dalian Medical University , Dalian , People's Republic of China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Wei
authors.affiliation: a School of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , People's Republic of China.
authors.forename: Dong
authors.initials: D
authors.lastname: Hao
authors.affiliation: a School of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.affiliation: a School of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , People's Republic of China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Tao
authors.affiliation: a School of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , People's Republic of China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zhang
authors.affiliation: a School of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , People's Republic of China.
authors.forename: Xixiang
authors.initials: X
authors.lastname: Ying
authors.affiliation: d Regenerative Medicine Center , The First Affiliated Hospital of Dalian Medical University , Dalian , People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
mesh_terms: D000273:Adipose Tissue / Q000166:cytology; D000470:Alkaloids / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009019:Morphinans / Q000737:chemistry* / Q000494:pharmacology; D010077:Oxazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D031822:Portulaca / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D013234:Stem Cells / Q000187:drug effects
chemical_list: D000470:Alkaloids; D009019:Morphinans; D010077:Oxazepines; C000624864:oleraciamide A; C000624884:oleraciamide B
keywords: NMR; Portulaca oleracea L; alkaloids; cytotoxicity