title: [Red yeast-rice-induced muscular injuries: Analysis of French pharmacovigilance database and literature review].
abstract: Red yeast rice (RYR) is a dietary supplement containing monacolins obtained by fermentation of Monascus purpureus strains. Because of its structural homology with lovastatin, monacolin K inhibits HMG-CoA reductase and shows hypocholesterolemic properties comparable to synthetic statins. We studied all cases of myopathy involving RYR reported in the French national pharmacovigilance database (6 cases) and in scientific literature (9 cases). Among these cases, 9 showed elevated creatine kinase, 3 rhabdomyolysis and 2 myalgia. Recent studies seem to show good efficacy of the RYR, however, our work reports the existence of related muscular disorders. In addition, dietary supplements currently available on the market may show considerable variability of formulation and/or the presence of contaminants. When clinicobiological disorders occur, physicians should consider the eventual use of an herbal treatment.
authors.affiliation: Département de pharmacologie médicale et toxicologie, centre régional de pharmacovigilance et d'information sur le médicament, hôpital Lapeyronie, CHU Lapeyronie, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France. Electronic address: c-philibert@chu-montpellier.fr.
authors.forename: Christelle
authors.initials: C
authors.lastname: Philibert
authors.affiliation: Département de pharmacologie médicale et toxicologie, centre régional de pharmacovigilance et d'information sur le médicament, hôpital Lapeyronie, CHU Lapeyronie, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Bres
authors.affiliation: Centre régional de pharmacovigilance et d'information sur le médicament, hôpital Sainte-Marguerite, 13009 Marseille, France.
authors.forename: Marie-Josèphe
authors.initials: MJ
authors.lastname: Jean-Pastor
authors.affiliation: Centre régional de pharmacovigilance et d'information sur le médicament, hôpital Nord, CHU de Saint-Étienne, 42270 Saint-Priest-en-Jarez, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Guy
authors.affiliation: Coordination de pharmacovigilance d'Île-de-France, centre régional de pharmacovigilance et d'information sur le médicament, hôpital de la Pitié-Salpêtrière, 75013 Paris, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Lebrun-Vignes
authors.affiliation: Département de pharmacologie médicale et toxicologie, centre régional de pharmacovigilance et d'information sur le médicament, hôpital Lapeyronie, CHU Lapeyronie, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France.
authors.forename: Perrine
authors.initials: P
authors.lastname: Robin
authors.affiliation: Département de pharmacologie médicale et toxicologie, centre régional de pharmacovigilance et d'information sur le médicament, hôpital Lapeyronie, CHU Lapeyronie, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Pinzani
authors.affiliation: Département de pharmacologie médicale et toxicologie, centre régional de pharmacovigilance et d'information sur le médicament, hôpital Lapeyronie, CHU Lapeyronie, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Hillaire-Buys
keywords: Atteintes musculaires; Levure de riz rouge; Muscular injuries; Phytotherapy; Phytothérapie; Red yeast rice; Statin; Statine