title: Gelatin tannate and tyndallized probiotics: a novel approach for treatment of diarrhea.
abstract: Intestinal permeability impairment is implicated in many gastrointestinal (GI) diseases. Chronic diarrhea, defined as the presence of diarrhea for more than 3 weeks in adults and 2 weeks in children, requires a different diagnostic and therapeutic work-up than acute diarrhea. Gelatin tannate, by reducing the clinical activity of acute colitis and the proinflammatory effects of lipopolysaccharide (LPS), is emerging as a mucosal barrier protector.
  
  
  
  New therapeutic strategies focusing on the physiological function of the intestinal barrier, may offer an innovative approach for the clinical improvement of highly debilitating chronic GI diseases. We review the available data on the role of gelatin tannate and tyndallized probiotics in the treatment of diarrhea.
  
  
  
  Gelatin tannate and tyndallized probiotics can be used to re-establish the physiological functions of the gut barrier, as well as for preventing dysbiosis. There is evidence that due to their particular properties, gelatin tannate and tyndallized probiotics are highly effective in the treatment of acute gastroenteritis and may be especially indicated in the management of moderate and prolonged diarrhea.
  
  
  
  Gelatin tannate and tyndallized probiotics may be effective in the management of chronic diarrhea. Further clinical trials are necessary to further explore their effects in clinical practice.
authors.affiliation: Department of Internal Medicine, Gastroenterology Division, Catholic University of the Sacred Heart, A. Gemelli Foundation, School of Medicine, Rome, Italy. lopetusoloris@libero.it.
authors.forename: L
authors.initials: L
authors.lastname: Lopetuso
authors.forename: C
authors.initials: C
authors.lastname: Graziani
authors.forename: A
authors.initials: A
authors.lastname: Guarino
authors.forename: A
authors.initials: A
authors.lastname: Lamborghini
authors.forename: S
authors.initials: S
authors.lastname: Masi
authors.forename: V
authors.initials: V
authors.lastname: Stanghellini
mesh_terms: D003967:Diarrhea / Q000188:drug therapy*; D005759:Gastroenteritis / Q000188:drug therapy; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D005780:Gelatin / Q000627:therapeutic use*; D006801:Humans; D019936:Probiotics / Q000627:therapeutic use*; D013634:Tannins
chemical_list: D013634:Tannins; C586501:tannate gelatin; D005780:Gelatin