title: Predictors of vasovagal reactions during preoperative autologous blood donation: a single-institution analysis.
abstract: Studies examining risk factors associated with vasovagal reactions (VVRs) during autologous blood donations, especially in younger subjects, have been limited. The aim of the present study was to define risk factors for VVRs during preoperative autologous blood donation in patients, including those younger than 18 years old. We retrospectively analyzed 4192 autologous, preoperative blood donations between 2007 and 2015 at Okayama University Hospital. Eighty-seven (2.08%) of the patients experienced VVRs. VVRs occurred approximately three times as often in patients 0-17 years old (16/320, 5.0%) than in patients 18 years and older (71/3872, 1.8%). In particular, VVRs occurred more frequently in those 10-13 years old, and decreased with older age (P = 0.006). In a univariate analysis, younger age, lower body mass index, lower systolic blood pressure, lower body weight, lower total blood volume, female gender, first-time collection, and higher heart rate were associated with a higher incidence of VVRs. In a multivariate analysis, lower systolic blood pressure (P < 0.001), higher heart rate (P = 0.007), and first-time collection (P = 0.015), remained independent predictors of VVRs. These results emphasize the need for careful attention during blood collection.
authors.affiliation: Department of Transfusion Medicine, Okayama University Hospital, Okayama, Japan. n-mori@md.okayama-u.ac.jp.|Department of Hematology and Oncology, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan. n-mori@md.okayama-u.ac.jp.
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Nishimori
authors.affiliation: Department of Transfusion Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Fujii
authors.affiliation: Department of Transfusion Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Fujii
authors.affiliation: Department of Transfusion Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Ikeda
authors.affiliation: Department of Transfusion Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Asano
authors.affiliation: Department of Transfusion Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ogo
authors.affiliation: Department of Nursing, Okayama University Hospital, Okayama, Japan.
authors.forename: Miwa
authors.initials: M
authors.lastname: Yamakawa
authors.affiliation: Department of Nursing, Okayama University Hospital, Okayama, Japan.
authors.forename: Naoe
authors.initials: N
authors.lastname: Takagi
authors.affiliation: Department of Transfusion Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Otsuka
authors.affiliation: Department of Transfusion Medicine, Okayama University Hospital, Okayama, Japan.|Japanese Red Cross Okayama Blood Center, Okayama, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001782:Blood Donors; D001804:Blood Transfusion, Autologous; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012307:Risk Factors; D019462:Syncope, Vasovagal / Q000453:epidemiology* / Q000209:etiology
keywords: Autologous blood donation; Vasovagal reactions