title: Risk Factors for Severe Bleeding Complications in Percutaneous Renal Biopsy.
abstract: Percutaneous renal biopsy is essential for diagnosis of many renal diseases. Previous studies have revealed a variety of factors associated with bleeding complications of renal biopsy; however, data are not sufficient in the Chinese population. We aimed to investigate the risk factors for severe post-biopsy bleeding events in a large cohort of Chinese patients.
  
  
  
  The data of patients who underwent percutaneous renal biopsy from January 2008 to December 2012 were collected. Severe bleeding complication was defined as requiring intervention, including blood transfusion or an invasive procedure (radiological or surgical) due to bleeding. Logistic regression analysis was used to assess risk factors.
  
  
  
  Over the 5-year period, 3,577 native kidney biopsies were performed. Severe bleeding complication occurred in 14 biopsies (0.39%). The patients with complications were older, had higher blood pressure, lower hemoglobin, lower platelet count and worse renal function. Multivariable logistic regression demonstrated that platelet level and the estimated glomerular filtration rate were independently associated with the risk of complications. Each 10 × 109/L increase of platelet count was associated with an 11% decrease of severe bleeding risk (odds ratio = 0.89; 95% CI: 0.80-0.98; P = 0.02). Each 1mL/minute/1.73m2increase of the estimated glomerular filtration rate was associated with a 4% decrease of severe bleeding risk (odds ratio = 0.96; 95% CI: 0.94-0.99; P = 0.004).
  
  
  
  Patients with worse renal function and lower platelet counts had a higher risk of developing severe bleeding events after renal biopsy.
authors.affiliation: Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China; Key Laboratory of Renal Disease, National Health and Family Planning Commission of the People׳s Republic of China, Beijing, PR China.
authors.forename: Da-Min
authors.initials: DM
authors.lastname: Xu
authors.affiliation: Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China; Key Laboratory of Renal Disease, National Health and Family Planning Commission of the People׳s Republic of China, Beijing, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China; Key Laboratory of Renal Disease, National Health and Family Planning Commission of the People׳s Republic of China, Beijing, PR China. Electronic address: zhoufude1801@vip.sina.com.
authors.forename: Fu-de
authors.initials: FD
authors.lastname: Zhou
authors.affiliation: Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China; Key Laboratory of Renal Disease, National Health and Family Planning Commission of the People׳s Republic of China, Beijing, PR China.
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Zhao
mesh_terms: D000328:Adult; D001706:Biopsy / Q000009:adverse effects*; D002681:China / Q000453:epidemiology; D005260:Female; D006470:Hemorrhage / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Bleeding complication; Hematoma; Hematuria; Renal biopsy; Risk factor