title: Pharmacokinetic herb-drug interaction of Xuesaitong dispersible tablet and aspirin after oral administration in blood stasis model rats.
abstract: BACKGROUND
  Xuesaitong dispersible tablet (XST) product has been clinically proven to be effective for treating cardio-cerebrovascular disease. Furthermore, herb-drug interactions between the XST product and drugs that are commonly co-administered, such as aspirin (ASA), must be explored to ensure safe clinical use.
  
  
  METHODS
  The current study aims to investigate whether the XST product interacts with ASA when they are administered concomitantly to ensure safety and efficacy. A ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of ginsenoside Rg1 (Rg1), ginsenoside Rd (Rd), notoginsenoside R1 (R1) and salicylic acid (SA) in rat plasma to investigate the pharmacokinetic interaction of XST and ASA in blood stasis model rats.
  
  
  CONCLUSIONS
  The ASA and XST combination noticeably altered R1 and Rg1 absorption, distribution and disposition. This study indicates that co-administration of XST and ASA can cause an apparent herb-drug pharmacokinetic interaction in blood stasis model rats.
authors.affiliation: Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Dai
authors.affiliation: Department of Pharmacy Office, Zhangjiagang Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, China.
authors.forename: Zhitao
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China.
authors.forename: Yongtao
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of gastroenterology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Nephrology, Liyang Hospital of Traditional Chinese Medicine, Liyang, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Bai
authors.affiliation: Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China. Electronic address: juwz333@hotmail.com.
authors.forename: Wenzheng
authors.initials: W
authors.lastname: Ju
authors.affiliation: Department of Nephrology, Liyang Hospital of Traditional Chinese Medicine, Liyang, China. Electronic address: prh64@sohu.com.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Pan
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000009:adverse effects*; D001810:Blood Volume / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D036145:Ginsenosides / Q000493:pharmacokinetics*; D041743:Herb-Drug Interactions; D006706:Homeostasis / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000009:adverse effects* / Q000493:pharmacokinetics*
chemical_list: D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D012503:Saponins; C509799:xuesetong; D001241:Aspirin
keywords: Aspirin; Herb–drug interaction; Pharmacokinetics; UHPLC-MS/MS; Xuesaitong dispersible tablet