title: [Specificity of spatial organization of evoked EEG rhythms in patients with paranoid schizophrenia].
abstract: OBJECTIVE
  The study aimed at analyzing the spatial patterns of evoked event-related oscillations in patients with paranoid schizophrenia and their relationship with clinical symptoms of disease.
  
  
  METHODS
  Evoked delta, theta, alpha, beta, and gamma rhythms in response to target auditory stimulus in an oddball paradigm were studied in 21 schizophrenic patients and 22 healthy subjects. The independent spatial patterns were revealed within each of the frequency range using the principal component analysis. Each spatial pattern was characterized by the specificity of intra- and inter-hemispheric relations.
  
  
  CONCLUSIONS
  The schizophrenic patients were characterized by a decrease in the evoked activity in the theta range with the most pronounced changes in the frontal-central areas of the right hemisphere and parietal-occipital areas bilaterally. Associations of the evoked rhythms with PANSS positive and negative symptoms were identified. The study demonstrated the high functional significance of evoked EEG rhythms changes for neurophysiological characteristics of patients with paranoid schizophrenia.
authors.affiliation: Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, Russia.
authors.forename: V K
authors.initials: VK
authors.lastname: Bochkarev
authors.affiliation: Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kirenskaya
authors.affiliation: Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Solnceva
authors.affiliation: Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Tkachenko
mesh_terms: D000328:Adult; D058256:Brain Waves; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012563:Schizophrenia, Paranoid / Q000503:physiopathology*; D055815:Young Adult