title: One-pot synthesis of α,β-epoxy ketones through domino reaction between alkenes and aldehydes catalyzed by proline based chiral organocatalysts.
abstract: Proline based metal free organocatalysts were developed by using a new approach for the synthesis of epoxide derivatives through a domino reaction. This domino reaction (oxidative coupling) allows a direct access to epoxides from various alkenes and aldehydes through C-H functionalization and C-C/C-O bond formation. The catalytic efficiencies of the newly synthesized organocatalysts were also determined by domino reaction in the presence of various functional groups containing aldehyde and alkene derivatives with very good yields (up to 95%) and ee's (up to 99%).
authors.affiliation: Supramolecular and Organometallic Chemistry Lab, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India. drasiva@gmail.com.
authors.forename: Veeramanoharan
authors.initials: V
authors.lastname: Ashokkumar
authors.affiliation: Supramolecular and Organometallic Chemistry Lab, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India. drasiva@gmail.com.
authors.forename: Ayyanar
authors.identifier: http://orcid.org/0000-0003-3930-9403
authors.initials: A
authors.lastname: Siva