title: Leptin Levels in Patients with Type 1 Diabetes Mellitus After Fetal Pancreatic Stem Cell Transplant.
abstract: OBJECTIVE
  Our objective was to determine leptin levels in patients with type 1 diabetes mellitus after fetal pancreatic stem cell transplant.
  
  
  METHODS
  Seven patients, aged 20 to 42 years, with type 1 diabetes mellitus received a fetal pancreatic stem cell transplant by intravenous infusion. The quantity of fetal stem cells infused was ≥ 5 × 10⁶, and the cells were of 12 to 14 weeks of gestation. We analyzed the levels of leptin, C-peptide, and antibodies to the islets of Langerhans before and 3 months after the transplant procedure.
  
  
  RESULTS
  Fetal pancreatic stem cell transplant led to significant increases in leptin and C-peptide levels, from 4.63 ± 1.17 ng/mL and 0.09 ± 0.02 ng/mL to 7.71 ± 1.45 ng/mL (P < .05) and 0.22 ± 0.05 ng/mL (P < .005), respectively, without an increase in antibodies to the islets of Langerhans, which measured 0.64 ± 0.13 U/mL before transplant and 0.57 ± 0.18 U/mL 3 months later (P > .05).
  
  
  CONCLUSIONS
  Leptin levels increase significantly within 3 months of fetal pancreatic stem cell transplant in patients with type 1 diabetes mellitus.
authors.affiliation: Department of Internal Medicine, National Scientific Medical Research Center, Astana, Kazakhstan.
authors.forename: Olga
authors.initials: O
authors.lastname: Ulyanova
authors.forename: Abay
authors.initials: A
authors.lastname: Baigenzhin
authors.forename: Zhannat
authors.initials: Z
authors.lastname: Taubaldieva
authors.forename: Saltanat
authors.initials: S
authors.lastname: Tuganbekova
authors.forename: Larissa
authors.initials: L
authors.lastname: Kozina
authors.forename: Samat
authors.initials: S
authors.lastname: Saparbayev
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D053686:Fetal Stem Cells / Q000637:transplantation*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D016035:Pancreas Transplantation / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002096:C-Peptide; D020738:Leptin