title: Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia.
abstract: Cancer, one of the principal causes of death, is a global social health problem. Autoantibodies developed against the organism's self-antigens are detected in the sera of subjects with cancer. In recent years carbonic anhydrase (CA) I and II autoantibodies have been shown in some autoimmune diseases and carcinomas, but the mechanisms underlying this immune response have not yet been explained. The aim of this study was to evaluate CA I and II autoantibodies in patients with acute myeloid leukemia (AML) and to provide a novel perspective regarding the autoimmune basis of the disease.
  
  
  
  Anti-CA I and II antibody levels were investigated using ELISA in serum samples from 30 patients with AML and 30 healthy peers.
  
  
  
  Anti-CA I and II antibody titers in the AML group were significantly higher compared with the control group (p=0.0001 and 0.018, respectively). A strong positive correlation was also determined between titers of anti-CA I and II antibodies (r=0.613, p=0.0001).
  
  
  
  Our results suggest that these autoantibodies may be involved in the pathogenesis of AML. More extensive studies are now needed to reveal the entire mechanism.
authors.affiliation: Karadeniz Technical University Vocational School of Health Sciences, Program of Medical Laboratory Techniques, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Menteşe
authors.affiliation: Karadeniz Technical University Faculty of Medicine, Department of Hematology, Trabzon, Turkey.
authors.forename: Nergiz
authors.initials: N
authors.lastname: Erkut
authors.affiliation: Karadeniz Technical University Faculty of Health Sciences, Department of Nutrition and Dietetics, Trabzon, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Demir
authors.affiliation: Karadeniz Technical University Faculty of Medicine, Department of Medical Biochemistry, Trabzon, Turkey.
authors.forename: Serap
authors.initials: S
authors.lastname: Özer Yaman
authors.affiliation: Recep Tayyip Erdoğan University Faculty of Health Services, Department of Nursing, Rize, Turkey.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Sümer
authors.affiliation: Karadeniz Technical University Faculty of Medicine, Department of Medical Biochemistry, Trabzon, Turkey.
authors.forename: Şeniz
authors.initials: Ş
authors.lastname: Doğramacı
authors.affiliation: Karadeniz Technical University Faculty of Medicine, Department of Medical Biochemistry, Trabzon, Turkey.|Recep Tayyip Erdoğan University Faculty of Medicine, Department of Medical Biochemistry, Rize, Turkey
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alver
authors.affiliation: Karadeniz Technical University Faculty of Medicine, Department of Hematology, Trabzon, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sönmez
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D024401:Carbonic Anhydrase I / Q000276:immunology*; D024402:Carbonic Anhydrase II / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; D024401:Carbonic Anhydrase I; D024402:Carbonic Anhydrase II
keywords: Acute myeloid leukemia; Autoantibody; Cancer Carbonic anhydrase.