title: Body Composition, Anthropometric Indices and Hydration Status of Obstructive Sleep Apnea Patients: Can Cachexia Coexist with Obesity?
abstract: The aim of this study was to elucidate body composition, anthropometric indices, and hydration status in obstructive sleep apnea (OSA) patients, taking into account different disease stages, gender, and the possibility of the presence of cachexia. There were 98 OSA patients and 23 control subjects enrolled into the study. All study participants underwent polysomnography examination. Body mass index (BMI), fat mass index (FMI), fat free mass, muscle mass, body cell mass, total body water, and extracellular and intracellular water were evaluated. The neck, abdominal, and waist circumference was measured. We found that overweight and obesity were present in 96% of patients. Cachexia was present in one OSA individual with comorbidities. Apnea-hypopnea index correlated with the neck and waist circumference, and with BMI in OSA patients. All muscle indices and water contents above outlined were significantly higher in severe OSA compared with control subjects. BMI, FMI, neck circumference, and extracellular water were greater in a subset of severe OSA compared with a moderate OSA stage. The female OSA patients had a higher FMI than that present in males at a comparable BMI. We conclude that the most body composition indices differed significantly between severe OSA patients and control subjects. A higher FMI in females at a comparable BMI could be due to a discordance between BMI and FMI. Cachexia occurs rarely in OSA and seems to coexist with comorbidities.
authors.affiliation: Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569, Poznan, Poland. kaminska@ump.edu.pl.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kuźnar-Kamińska
authors.affiliation: Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569, Poznan, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Grabicki
authors.affiliation: Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569, Poznan, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Trafas
authors.affiliation: Department of Internal Diseases, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Szulińska
authors.affiliation: Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569, Poznan, Poland.
authors.forename: Szczepan
authors.initials: S
authors.lastname: Cofta
authors.affiliation: Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569, Poznan, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Piorunek
authors.affiliation: Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569, Poznan, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Brajer-Luftmann
authors.affiliation: Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569, Poznan, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Nowicka
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bromińska
authors.affiliation: Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569, Poznan, Poland.
authors.forename: Halina
authors.initials: H
authors.lastname: Batura-Gabryel
mesh_terms: D001823:Body Composition; D015992:Body Mass Index; D002100:Cachexia / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications*; D017286:Polysomnography; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications*
keywords: Apnea-hypopnea index; Body composition; Body water content; Cachexia; Hydration; Nutritional status; Obesity; Obstructive sleep apnea