title: Intrathecal Injection of Peripherally Mobilized Blood Stem Cells to Treat Multiple Sclerosis.
abstract: In this study, we analyzed 70 patients with worseningmultiple sclerosis despite pharmacologic treatment who were treated with several intrathecal injections of peripheral blood cells harvested by apheresis after granulocyte-colony stimulating factor treatment. Thirty-seven patients (52%) had a reduction of Expanded Disability Status Scale score; 10 patients had relapses, although these were milder than usual and more easily controlled by corticosteroids. Because mesenchymal cells increase in the peripheral blood after granulocyte-colony stimulating factor stimulation, a peripheral blood harvest seems easier and less costly than mesenchymal cell cultivation before injection. This seems to be a reasonable treatment for progressive multiple sclerosis.
authors.affiliation: Iraqi Stem Cell Center, Alyermook Teaching Hospital, Baghdad, Iraq.
authors.forename: Abdul Majeed
authors.initials: AM
authors.lastname: Hammadi
authors.forename: Fizel Abbas
authors.initials: FA
authors.lastname: Al-Himyari
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001781:Blood Component Removal; D004185:Disability Evaluation; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones