title: Epigenetics in Stroke Recovery.
abstract: While the death rate from stroke has continually decreased due to interventions in the hyperacute stage of the disease, long-term disability and institutionalization have become common sequelae in the aftermath of stroke. Therefore, identification of new molecular pathways that could be targeted to improve neurological recovery among survivors of stroke is crucial. Epigenetic mechanisms such as post-translational modifications of histone proteins and microRNAs have recently emerged as key regulators of the enhanced plasticity observed during repair processes after stroke. In this review, we highlight the recent advancements in the evolving field of epigenetics in stroke recovery.
authors.affiliation: Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA. haifa.kassis@gmail.com.
authors.forename: Haifa
authors.initials: H
authors.lastname: Kassis
authors.affiliation: Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA. amjad.shehadah@gmail.com.
authors.forename: Amjad
authors.initials: A
authors.lastname: Shehadah
authors.affiliation: Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA. michael.chopp@gmail.com.|Department of Physics, Oakland University, Rochester, MI 48309, USA. michael.chopp@gmail.com.
authors.forename: Michael
authors.initials: M
authors.lastname: Chopp
authors.affiliation: Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA. zzhang1@hfhs.org.
authors.forename: Zheng Gang
authors.initials: ZG
authors.lastname: Zhang
keywords: epigenetics; recovery; stroke