title: Ion channels or aquaporins as novel molecular targets in gastric cancer.
abstract: Gastric cancer (GC) is a common disease with few effective treatment choices and poor prognosis, and has the second-highest mortality rates among all cancers worldwide. Dysregulation and/or malfunction of ion channels or aquaporins (AQPs) are common in various human cancers. Furthermore, ion channels are involved in numerous important aspects of the tumor aggressive phonotype, such as proliferation, cell cycle, apoptosis, motility, migration, and invasion. Indeed, by localizing in the plasma membrane, ion channels or AQPs can sense and respond to extracellular environment changes; thus, they play a crucial role in cell signaling and cancer progression. These findings have expanded a new area of pharmaceutical exploration for various types of cancer, including GC. The involvement of multiple ion channels, such as voltage-gated potassium and sodium channels, intracellular chloride channels, 'transient receptor potential' channels, and AQPs, which have been shown to facilitate the pathogenesis of other tumors, also plays a role in GC. In this review, an overview of ion channel and aquaporin expression and function in carcinogenesis of GC is presented. Studies of ion channels or AQPs will advance our understanding of the molecular genesis of GC and may identify novel and effective targets for the clinical application of GC.
authors.affiliation: Cancer Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Hospital of the University of Electronic Science and Technology of China, The Western First Round Road, Section 2#32, Chengdu, 610072, China.|Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Jianling
authors.initials: J
authors.lastname: Xia
authors.affiliation: Department of Oncology, Zhoushan Hospital, Zhoushan, 316000, China.|Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Hongqiang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Urology, Hainan Provincial People's Hospital, Haikou, 570311, China.
authors.forename: Qinghui
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Huang
authors.affiliation: Cancer Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Hospital of the University of Electronic Science and Technology of China, The Western First Round Road, Section 2#32, Chengdu, 610072, China. miller2002@yahoo.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Zeng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D020346:Aquaporins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D020346:Aquaporins; D007473:Ion Channels
keywords: Aquaporin; Calcium; Chloride; Gastric cancer; Ion channels; Potassium; Sodium; Therapeutic target