title: HIV-Associated Anal Dysplasia and Anal Carcinoma.
abstract: Anal carcinoma shows an increasing incidence in people living with human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) in whom it is also much more common compared to the HIV-negative population. Human papillomavirus infection is the etiological basis of malignant development in the anal epithelium. Therefore, adequate diagnosis and treatment of the precursor lesions (anal intraepithelial neoplasia) is of clinical importance. In cases with preserved immune function, anal cancer can be treated according to guidelines issued for HIV-negative patients. This review summarizes the current knowledge regarding anal malignancies in HIV-positive patients.
authors.forename: Mark
authors.initials: M
authors.lastname: Oette
authors.forename: Franz A
authors.initials: FA
authors.lastname: Mosthaf
authors.forename: Marie-Luise
authors.initials: ML
authors.lastname: Sautter-Bihl
authors.forename: Stefan
authors.initials: S
authors.lastname: Esser
mesh_terms: D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001005:Anus Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination / Q000379:methods / Q000592:standards; D019317:Evidence-Based Medicine; D015658:HIV Infections / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008495:Medical Oncology / Q000592:standards; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
chemical_list: D044966:Anti-Retroviral Agents; D000970:Antineoplastic Agents