title: Comparison of 3 Devices for Automated Infusion of Positron-Emitting Radiotracers.
abstract: The administration accuracy and precision of an automated infusion device for positron-emitting radiotracers are directly associated with bias and variance in the SUVs of18F-FDG PET/CT. Therefore, the accuracy of such devices must be confirmed and calibrated at locations in which they are used. The present study aimed to validate the administration accuracy of 3 automated infusion devices for quantitative PET assessment.Methods:Temporal variations as well as variations in radioactive concentrations and dispensed volumes of18F-FDG were determined for the M-130, AI-300, and UG-05 automated infusion devices. The total-test dispensed volumes were 25, 20, and 18.5 mL, respectively. A reference value was generated by measuring amounts of radioactivity using a standard dose calibrator. Administration accuracy was validated according to the criteria of the Japanese Society of Nuclear Medicine.Results:The temporal variation in the M-130 and UG-05 for a specified 185 MBq was relatively stable, in the range of -1.60%-0.92% and 1.16%-5.35%, respectively, whereas that in the AI-300 was -0.55%-8.68%. For the M-130 and UG-05 devices, the difference between measured and reference value was in the range of -5%-5%. The values measured by the AI-300 deviated from the reference values by a maximum of 30%, which depends on radioactive concentration and dispensed volume of18F-FDG.Conclusion:The administration accuracy of the AI-300 varied considerably under different conditions, but a software update might somewhat improve this. Our findings indicate that dispensed volumes of18F-FDG should be carefully considered when the radioactive concentration is high. Administration accuracy should be regularly confirmed at each location to maintain the quality of quantitative PET assessment. The present study provides useful information about how to confirm the administration accuracy of automated infusion devices.
authors.affiliation: Department of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Miyaji
authors.affiliation: Department of Radiological Sciences, School of Health Sciences, International University of Health and Welfare, Tochigi, Japan kenta5710@gmail.com.
authors.forename: Kenta
authors.initials: K
authors.lastname: Miwa
authors.affiliation: Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan; and.
authors.forename: Kei
authors.initials: K
authors.lastname: Wagatsuma
authors.affiliation: Department of Radiology, Chiba University Hospital, Chiba, Japan.
authors.forename: Taisuke
authors.initials: T
authors.lastname: Murata
authors.affiliation: Department of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
authors.forename: Takuro
authors.initials: T
authors.lastname: Umeda
authors.affiliation: Department of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Terauchi
authors.affiliation: Department of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Koizumi
mesh_terms: D001331:Automation; D019788:Fluorodeoxyglucose F18; D049268:Positron-Emission Tomography / Q000295:instrumentation*; D011849:Radioactive Tracers
chemical_list: D011849:Radioactive Tracers; D019788:Fluorodeoxyglucose F18
keywords: administration accuracy; automated infusion device; dose calibrator; positron emission tomography (PET); quantitative PET; radiation exposure