title: Chymotrypsin with sialendoscopy-assisted surgery for the treatment of chronic obstructive parotitis.
abstract: Chronic obstructive parotitis (COP) is a common disease of the parotid gland. A total of 104 patients with COP were identified and randomized into a treatment group (52 cases) and a control group (52 cases). All patients underwent sialography and salivary gland scintigraphy (SGS) examinations before surgery. The patients in the treatment group received chymotrypsin combined with gentamicin via interventional sialendoscopy to irrigate the duct, and the control group received gentamicin alone. All patients were asked to record their pain on a visual analogue scale (VAS) before treatment and at 1 week, 2 weeks, 1 month, 3 months, and 6 months after surgery. The VAS score for pain intensity was decreased at 1 week post-treatment in both groups (P<0.05). Compared to the control group, the VAS score was lower in the treatment group at 1 week, 2 weeks, and 1 month post-treatment (P<0.05). The 6-month postoperative SGS results showed improved uptake and excretion in both groups (P<0.05). The treatment group exhibited higher scores for postoperative SGS excretion than the control group (P<0.05). The administration of chymotrypsin combined with gentamicin by sialendoscopy is effective for the treatment of non-stone-related COP and specifically improves the excretion function of the parotid gland.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, China; Liaoning Institute of Dental Research, Shenyang, Liaoning Province, PR China.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Sun
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, China; Liaoning Institute of Dental Research, Shenyang, Liaoning Province, PR China.
authors.forename: J-Q
authors.initials: JQ
authors.lastname: Xiao
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, China; Liaoning Institute of Dental Research, Shenyang, Liaoning Province, PR China.
authors.forename: Q-H
authors.initials: QH
authors.lastname: Qiao
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, China; Liaoning Institute of Dental Research, Shenyang, Liaoning Province, PR China.
authors.forename: X
authors.initials: X
authors.lastname: Bao
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, China; Liaoning Institute of Dental Research, Shenyang, Liaoning Province, PR China.
authors.forename: C-B
authors.initials: CB
authors.lastname: Wu
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, China; Liaoning Institute of Dental Research, Shenyang, Liaoning Province, PR China. Electronic address: zqforstudent@163.com.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D002918:Chymotrypsin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004724:Endoscopy / Q000379:methods*; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010147:Pain Measurement; D010309:Parotitis / Q000000981:diagnostic imaging / Q000601:surgery*; D012796:Sialography; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002918:Chymotrypsin
keywords: chronic obstructive parotitis; chymotrypsin; salivary gland scintigraphy; sialendoscopy