title: [Comparison of the expression profile of surface molecular markers on mesenchymal stromal cell cultures isolated from human endometrium and umbilical cord].
abstract: Endometrial mesenchymal stromal cells (eMSCs), along with mesenchymal stromal cells (MSCs) isolated from other tissues, are promising for use in regenerative medicine. The benefits of eMSCs include their presence in adults, simplicity of isolation, high proliferative and differentiation capacity. In this study, we have employed the flow cytometry technique to assess expression of 28 molecular markers on the surface of two eMSCs cultures. The culture of MSCs isolated from Wharton's jelly of the umbilical cord (uMSCs) was used as a reference, because uMSCs were studied in details earlier and demonstrated their effectiveness in vivo. Both types of MSCs demonstrated similar expression profiles. They included stem cells surface molecules, cell adhesion molecules and their ligands, some receptor molecules responsible for cell metabolism and proliferation, as well as immunological response molecules.
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Lupatov
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: R Yu
authors.initials: RY
authors.lastname: Saryglar
authors.affiliation: Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia.
authors.forename: V D
authors.initials: VD
authors.lastname: Chuprynin
authors.affiliation: Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Pavlovich
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: K N
authors.initials: KN
authors.lastname: Yarygin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D004717:Endometrium / Q000166:cytology / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D063990:Gene Ontology; D006680:HLA Antigens / Q000235:genetics / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D058977:Molecular Sequence Annotation; D061251:Primary Cell Culture; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D014470:Umbilical Cord / Q000166:cytology / Q000378:metabolism*; D059631:Wharton Jelly / Q000166:cytology / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D006680:HLA Antigens; D011956:Receptors, Cell Surface
keywords: endometrium; mesenchymal stem cells; mesenchymal stromal cells; molecular markers; umbilical cord