title: Mimicking Neurotransmitter Release in Chemical Synapses via Hysteresis Engineering in MoS2Transistors.
abstract: Neurotransmitter release in chemical synapses is fundamental to diverse brain functions such as motor action, learning, cognition, emotion, perception, and consciousness. Moreover, improper functioning or abnormal release of neurotransmitter is associated with numerous neurological disorders such as epilepsy, sclerosis, schizophrenia, Alzheimer's disease, and Parkinson's disease. We have utilized hysteresis engineering in a back-gated MoS2field effect transistor (FET) in order to mimic such neurotransmitter release dynamics in chemical synapses. All three essential features, i.e., quantal, stochastic, and excitatory or inhibitory nature of neurotransmitter release, were accurately captured in our experimental demonstration. We also mimicked an important phenomenon called long-term potentiation (LTP), which forms the basis of human memory. Finally, we demonstrated how to engineer the LTP time by operating the MoS2FET in different regimes. Our findings could provide a critical component toward the design of next-generation smart and intelligent human-like machines and human-machine interfaces.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Arnold
authors.affiliation: GLOBALFOUNDRIES , Albany NanoTech Complex, Albany, New York 12203, United States.
authors.forename: Ali
authors.initials: A
authors.lastname: Razavieh
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Nasr
authors.forename: Daniel S
authors.identifier: 0000-0002-0751-0578
authors.initials: DS
authors.lastname: Schulman
authors.forename: Chad M
authors.initials: CM
authors.lastname: Eichfeld
authors.forename: Saptarshi
authors.identifier: 0000-0002-0188-945X
authors.initials: S
authors.lastname: Das
mesh_terms: D004220:Disulfides / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008982:Molybdenum / Q000737:chemistry / Q000378:metabolism*; D016571:Neural Networks, Computer; D018377:Neurotransmitter Agents / Q000737:chemistry / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*; D009435:Synaptic Transmission
chemical_list: D004220:Disulfides; D018377:Neurotransmitter Agents; D008982:Molybdenum; C082964:molybdenum disulfide
keywords: MoS2 field effect transistor; chemical synapse; gate hysteresis; long-term potentiation; neurotransmitter release