title: Transoral laser microsurgery or total laryngectomy for recurrent squamous cell carcinoma of the larynx: Retrospective analysis of 199 cases.
abstract: Surgical treatment options for local recurrences of laryngeal cancer can be either organ-preserving surgery or total laryngectomy. The purpose of this study was to present our evaluation of the treatment with transoral laser microsurgery (TLM) in comparison to laryngectomy.
  
  
  
  We conducted a retrospective review of 199 consecutive patients with recurrent laryngeal cancer at 1 tertiary referral center.
  
  
  
  The 5-year overall survival, disease-specific survival, and local control rates were 64.8%, 79.6%, and 57.5%, respectively, for 93 patients with early tumors treated by TLM, 28.9%, 41.7%, and 43.7%, respectively, for 52 patients with advanced tumors treated by TLM as well as 39.4%, 44.6%, and 68.8%, respectively, for 54 patients with advanced tumors treated by total laryngectomy. Five-year larynx-preservation rate was 77.7% for early as well as 68.4% for advanced tumors treated by TLM.
  
  
  
  TLM is an option in early and in selected cases of advanced locally recurrent laryngeal cancer. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1166-1176, 2017.
authors.affiliation: Department of Otorhinolaryngology, University Medical Center Göttingen, Georg-August University Göttingen, Robert-Koch-Straße 40, Göttingen, Germany.
authors.forename: Bernhard G
authors.identifier: 0000-0002-8368-0149
authors.initials: BG
authors.lastname: Weiss
authors.affiliation: Department of Otorhinolaryngology, University Medical Center Göttingen, Georg-August University Göttingen, Robert-Koch-Straße 40, Göttingen, Germany.
authors.forename: Mattis
authors.initials: M
authors.lastname: Bertlich
authors.affiliation: Department of Otorhinolaryngology, University Medical Center Göttingen, Georg-August University Göttingen, Robert-Koch-Straße 40, Göttingen, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Canis
authors.affiliation: Department of Otorhinolaryngology, University Medical Center Göttingen, Georg-August University Göttingen, Robert-Koch-Straße 40, Göttingen, Germany.
authors.forename: Friedrich
authors.identifier: 0000-0001-7066-4994
authors.initials: F
authors.lastname: Ihler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D007825:Laryngectomy / Q000379:methods* / Q000401:mortality; D053685:Laser Therapy / Q000379:methods* / Q000401:mortality; D008297:Male; D008866:Microsurgery / Q000379:methods* / Q000401:mortality; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D018570:Risk Assessment; D016879:Salvage Therapy / Q000379:methods; D000077195:Squamous Cell Carcinoma of Head and Neck; D018709:Statistics, Nonparametric; D016019:Survival Analysis
keywords: laryngeal neoplasms; laryngectomy; local; neoplasm recurrence; retrospective study; transoral laser microsurgery