title: Asymmetric organocatalytic methods for the synthesis of tetrahydropyrans and their application in total synthesis.
abstract: Recent advancement in the area of asymmetric organocatalysis led to the development of new methodologies for the construction of valuable enantiopure molecules, including various heterocycles. As one of the latter class of compounds tetrahydropyrans (THPs) constitute a core structure of a wide array of bioactive natural products. A noticeable growth has been observed in the asymmetric synthesis of THPs using small organic molecules as catalysts. This Tutorial Review describes the organocatalytic methods available to furnish THPs as well as the application of these methodologies in the total synthesis of THP-based natural products.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany. enders@rwth-aachen.de.
authors.forename: Fabrizio
authors.identifier: http://orcid.org/0000-0002-7171-8779
authors.initials: F
authors.lastname: Vetica
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany. enders@rwth-aachen.de.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Chauhan
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany. enders@rwth-aachen.de.
authors.forename: Simon
authors.initials: S
authors.lastname: Dochain
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany. enders@rwth-aachen.de.
authors.forename: Dieter
authors.identifier: http://orcid.org/0000-0001-6956-7222
authors.initials: D
authors.lastname: Enders