title: Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes.
abstract: The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance. A total of 271 unrelated Chinese postmenopausal women were recruited in this study. The subjects were divided into type 2 diabetes mellitus (T2DM) group (n= 93), impaired glucose regulation (IGR) (n= 90), and normal glucose regulation group (NGR) (n= 88), according to different glucose regulation categories. Serum OPG levels were measured by enzyme-linked immunosorbent assay. The serum OPG concentration in NGR group, 151.00 ± 45.72 pg/mL, was significantly lower than that in IGR group (169.28 ± 64.91 pg/mL) (p= 0.031) and T2DM group (183.20 ± 56.53 pg/mL) (p< 0.01), respectively. In multiple linear regression analysis, HOMA-IR, age, 2hPG, AST, ALP, and eGFR were found to be independent predictors of OPG. Increased serum OPG levels (OR = 1.009,p= 0.006) may be a risk factor for insulin resistance. The present study suggests that OPG might be implicated in the pathogenesis of diabetes and is a potential biomarker of insulin resistance in subjects with diabetes and prediabetes.
authors.affiliation: Department of Endocrinology and Metabolism, Nanchang Key Laboratory of Diabetes, The Third Hospital of Nanchang, No. 2 Xiangshan South Road, Nanchang, Jiangxi 330009, China.
authors.forename: Peng
authors.identifier: 0000-0003-2199-7084
authors.initials: P
authors.lastname: Duan
authors.affiliation: Department of Finance, Nanchang Normal University, No. 889 Ruixiang Road, Nanchang, Jiangxi 330009, China.
authors.forename: Min
authors.identifier: 0000-0002-9806-1519
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Endocrinology and Metabolism, Nanchang Key Laboratory of Diabetes, The Third Hospital of Nanchang, No. 2 Xiangshan South Road, Nanchang, Jiangxi 330009, China.
authors.forename: Meilin
authors.identifier: 0000-0001-5198-225X
authors.initials: M
authors.lastname: Wei
authors.affiliation: Department of Endocrinology and Metabolism, Nanchang Key Laboratory of Diabetes, The Third Hospital of Nanchang, No. 2 Xiangshan South Road, Nanchang, Jiangxi 330009, China.
authors.forename: Jia
authors.identifier: 0000-0003-4272-2979
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Endocrinology and Metabolism, Nanchang Key Laboratory of Diabetes, The Third Hospital of Nanchang, No. 2 Xiangshan South Road, Nanchang, Jiangxi 330009, China.
authors.forename: Ping
authors.identifier: 0000-0002-0140-3595
authors.initials: P
authors.lastname: Tu