title: Study of Serum Carcinoembryonic Antigen's Profile for Breast Cancer in Western Algeria: 100 cases.
abstract: BACKGROUND
  Breast cancer is the most common cancer in women worldwide. Biology contributes to the early diagnosis and monitoring of breast cancer with several categories of markers such as prognostic markers (ER, PR, HER2), proliferative markers (Ki67), and tumor markers such as CEA and CA 15-3. CEA can be detected at a high concentration in serum of patients with malignant tumors.
  
  
  OBJECTIVE
  The aim of our study was to evaluate the concentrations of CEA in serum of women with breast cancer and to verify the existence of a possible link between the average rates of CEA and SBR grade.
  
  
  METHODS
  Serum samples from 100 patients with breast cancer and 100 controls was recovered and examined with an AxSYM analyzer (Abbott Laboratories, USA) to measure CEA using Microparticle Enzyme Immunoassay (MEIA) technology.
  
  
  RESULTS
  In our clinical study, the mean age of patients and controls were 52.7 and 50.3 years respectively. The results revealed an elevation in the CEA levels from patients with an average value of 16.61 ± 0.2 ng/ml. Positive correlation was found between CEA concentrations and SBR grade, it has found with 45,7 ± 1 ng/ml in grade III.
  
  
  CONCLUSIONS
  CEA represents an excellent marker for breast cancer development. Changes in its concentration reflect the effectiveness or ineffectiveness of treatment.
authors.affiliation: Laboratory of Developmental Biology and Differentiation, Faculty of Natural Sciences and Life, University of Oran1, Ahmed Ben Bella, Oran, Algeria.|Faculty of Natural Sciences and Life, University of Sciences and Technology Mohamed Boudiaf, Oran, Algeria.
authors.forename: Zenib
authors.initials: Z
authors.lastname: Tahari
authors.affiliation: Laboratory of Developmental Biology and Differentiation, Faculty of Natural Sciences and Life, University of Oran1, Ahmed Ben Bella, Oran, Algeria.|Faculty of Natural Sciences and Life, University of Sciences and Technology Mohamed Boudiaf, Oran, Algeria.
authors.forename: Asmahane
authors.initials: A
authors.lastname: Medjdoub
authors.affiliation: Laboratory of Developmental Biology and Differentiation, Faculty of Natural Sciences and Life, University of Oran1, Ahmed Ben Bella, Oran, Algeria.
authors.forename: Tewfik
authors.initials: T
authors.lastname: Sahraoui
authors.affiliation: Pasteur Institute of Oran, Gambetta Sylvain Parent Cave Gay Street, Oran, Algeria.
authors.forename: Leila
authors.initials: L
authors.lastname: Belhabri
authors.affiliation: Laboratory of Developmental Biology and Differentiation, Faculty of Natural Sciences and Life, University of Oran1, Ahmed Ben Bella, Oran, Algeria.
authors.forename: Fatima Zohra
authors.initials: FZ
authors.lastname: El Kebir
mesh_terms: D000462:Algeria; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000276:immunology*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen