title: A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus.
abstract: MicroRNAs (miRNAs) are small noncoding RNAs that modulate the cellular transcriptome at the post-transcriptional level. miRNA plays important roles in different disease manifestation, including type 2 diabetes mellitus (T2DM). Many studies have characterized the changes of miRNAs in T2DM, a complex systematic disease; however, few studies have integrated these findings and explored the functional effects of the dysregulated miRNAs identified. To investigate the involvement of miRNAs in T2DM, we obtained and analyzed all relevant studies published prior to 18 October 2016 from various literature databases. From 59 independent studies that met the inclusion criteria, we identified 158 dysregulated miRNAs in seven different major sample types. To understand the functional impact of these deregulated miRNAs, we performed targets prediction and pathway enrichment analysis. Results from our analysis suggested that the altered miRNAs are involved in the core processes associated with T2DM, such as carbohydrate and lipid metabolisms, insulin signaling pathway and the adipocytokine signaling pathway. This systematic survey of dysregulated miRNAs provides molecular insights on the effect of deregulated miRNAs in different tissues during the development of diabetes. Some of these miRNAs and their mRNA targets may have diagnostic and/or therapeutic utilities in T2DM.
authors.affiliation: Institute of Medical Systems Biology, Guangdong Medical University, Dongguan 523808, China. dr.hyq@hotmail.com.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Epidemiology and Medical Statistics, Guangdong Medical University, Dongguan 523808, China. gdmcsbd@163.com.
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Epidemiology and Medical Statistics, Guangdong Medical University, Dongguan 523808, China. liangbiyu2017@hotmail.com.
authors.forename: Biyu
authors.initials: B
authors.lastname: Liang
authors.affiliation: Department of Epidemiology and Medical Statistics, Guangdong Medical University, Dongguan 523808, China. linjuanjuan2017@hotmail.com.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Lin
authors.affiliation: Institute for Systems Biology, Seattle, WC 98109, USA. tkim@systemsbiology.org.
authors.forename: Taek-Kyun
authors.initials: TK
authors.lastname: Kim
authors.affiliation: Department of Epidemiology and Medical Statistics, Guangdong Medical University, Dongguan 523808, China. hbyu616688@163.com.
authors.forename: Haibing
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of endocrinology, Zhongshan Chen Xinghai Hospital Affiliated to Guangdong Medical University, Zhongshan 528415, China. HuangHW662@163.com.
authors.forename: Hanwei
authors.initials: H
authors.lastname: Hang
authors.affiliation: Institute for Systems Biology, Seattle, WC 98109, USA. kwang@systemsbiology.org.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009928:Organ Specificity / Q000235:genetics; D034622:RNA Interference; D012333:RNA, Messenger / Q000235:genetics; D015398:Signal Transduction; D059467:Transcriptome
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger
keywords: miRNA-mRNA interaction network; microRNA; systematic study; type 2 diabetes mellitus