title: Water Transport Mediated by Other Membrane Proteins.
abstract: Water transport through membrane is so intricate that there are still some debates. (Aquaporins) AQPs are entirely accepted to allow water transmembrane movement depending on osmotic gradient. Cotransporters and uniporters , however, are also concerned in water homeotatsis. Urea transporter B (UT-B) has a single-channel water permeability that is similar to AQP1. Cystic fibrosis transmembrane conductance regulator (CFTR ) was initially thought as a water channel but now not believed to transport water directly. By cotranporters, water is transported by water osmosis coupling with substrates, which explains how water is transported across the isolated small intestine. This chapter provides information about water transport mediated by other membrane proteins except AQPs .
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
authors.forename: Boyue
authors.initials: B
authors.lastname: Huang
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.|Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Hongkai
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China. baoxue@bjmu.edu.cn.|State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China. baoxue@bjmu.edu.cn.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing, 100191, China. baoxue@bjmu.edu.cn.
authors.forename: Baoxue
authors.initials: B
authors.lastname: Yang
mesh_terms: D000818:Animals; D001692:Biological Transport; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics / Q000378:metabolism; D029382:Dicarboxylic Acid Transporters / Q000235:genetics / Q000378:metabolism; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism*; D027341:Excitatory Amino Acid Transporter 1 / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D027501:Monocarboxylic Acid Transporters / Q000235:genetics / Q000378:metabolism*; D029363:Organic Anion Transporters, Sodium-Dependent / Q000235:genetics / Q000378:metabolism; D009994:Osmolar Concentration; D051269:Sodium-Glucose Transporter 1 / Q000235:genetics / Q000378:metabolism; D064506:Solute Carrier Family 12, Member 2 / Q000235:genetics / Q000378:metabolism; D027981:Symporters / Q000235:genetics / Q000378:metabolism*; D014867:Water / Q000378:metabolism*; D000096982:Urea Transporters; D000099233:Monocarboxylate Transport Protein 1; D000096922:K Cl- Cotransporters
chemical_list: D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D029382:Dicarboxylic Acid Transporters; D027341:Excitatory Amino Acid Transporter 1; D026901:Membrane Transport Proteins; D027501:Monocarboxylic Acid Transporters; D029363:Organic Anion Transporters, Sodium-Dependent; D051269:Sodium-Glucose Transporter 1; D064506:Solute Carrier Family 12, Member 2; D027981:Symporters; D014867:Water; D000096982:Urea Transporters; D000099233:Monocarboxylate Transport Protein 1; C505032:CFTR protein, human; C119651:SLC12A7 protein, human; D000096922:K Cl- Cotransporters; C092524:SLC13A2 protein, human; C493394:SLC1A3 protein, human; C495674:SLC5A1 protein, human
keywords: CFTR; Cotransporter; Urea transporter B; Water transport