title: Analysis of a cardiovascular model for the study of the autonomic response of Brugada syndrome patients.
abstract: This paper describes the integration of mathematical models of the cardiac electrical activity, the cardiovascular system and the baroreceptor reflex control of the autonomic nervous system, with a model representing a head-up tilt test. Sensitivity analyses are performed in order to determine those model parameters producing the greatest significant effects on heart rate and blood pressure. An optimization step is then applied to the most influential parameters in order to find the best model fit to real cardiac data obtained from a patient suffering from Brugada syndrome and a healthy subject, in supine and upright postures during a tilt test. Results show the feasibility of the model to generate realistic autonomic responses to head-up tilt testing in health and disease.
authors.forename: Mireia
authors.initials: M
authors.lastname: Calvo
authors.forename: Virginie
authors.initials: V
authors.lastname: Le Rolle
authors.forename: Daniel
authors.initials: D
authors.lastname: Romero Perez
authors.forename: Nathalie
authors.initials: N
authors.lastname: Behar
authors.forename: Pedro
authors.initials: P
authors.lastname: Gomis
authors.forename: Philippe
authors.initials: P
authors.lastname: Mabo
authors.forename: Alfredo I
authors.initials: AI
authors.lastname: Hernandez
mesh_terms: D001341:Autonomic Nervous System / Q000502:physiology*; D001794:Blood Pressure; D053840:Brugada Syndrome / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D008955:Models, Cardiovascular; D011187:Posture; D018667:Tilt-Table Test