title: Magnetism-assisted modification of screen printed electrode with magnetic multi-walled carbon nanotubes for electrochemical determination of dopamine.
abstract: A simple and sensitive dopamine (DA) electrochemical sensor was fabricated based on magnetism-assisted modification of screen printed electrode (SPE) with magnetic multi-walled carbon nanotubes (mMWCNTs). The mMWCNTs modified electrodes (mMWCNTs/SPE) combines the advantages of SPE and the simultaneous contribution of magnetic nanoparticles (MNPs) and MWCNTs, increasing sensitivity and selectivity of DA detection. The linearity was found between 5μM to 180μM, with the limit of detection (LOD) of 0.43μM. In the mean time, this modified electrode exhibited excellent selectivity for DA detection with almost no interference from ascorbic acid (AA), which co-exists with DA in many bio-samples and causes common interference. Finally, this novel electrode has been applied to determine DA concentration in spiked human blood serum and satisfactory recovery was found in the range of 97.43-102.94% with the RSDs of less than 2.27%. This work developed a sensitive and reliable electrochemical analytical method based on mMWCNTs/SPE, which exhibits great potential for diagnosis of the diseases related to DA.
authors.affiliation: Shanghai Institute of Technology, Shanghai 201418, China; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Zhang
authors.affiliation: Shanghai Institute of Technology, Shanghai 201418, China; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Pei-Li
authors.initials: PL
authors.lastname: Xu
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zeng
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; Department of Chemistry and Biochemistry, Jackson State University, 1400 Lynch St., Jackson, MS 39217, USA.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Liu
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address: liaoxun@cib.ac.cn.
authors.forename: Xun
authors.initials: X
authors.lastname: Liao
authors.affiliation: Shanghai Institute of Technology, Shanghai 201418, China. Electronic address: mfhou@sit.edu.cn.
authors.forename: Mei-Fang
authors.initials: MF
authors.lastname: Hou
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry; D004298:Dopamine / Q000032:analysis* / Q000097:blood; D055664:Electrochemical Techniques; D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D037742:Nanotubes, Carbon / Q000737:chemistry; D015203:Reproducibility of Results
chemical_list: D058185:Magnetite Nanoparticles; D037742:Nanotubes, Carbon; D001205:Ascorbic Acid; D004298:Dopamine
keywords: Dopamine; Electrochemistry; Magnetic multi-walled carbon nanotubes; Screen printed electrode