title: Maternal and perinatal outcomes in pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion and real time continuous glucose monitoring in two specialized centers in Medellin, Colombia.
abstract: OBJECTIVE
  We assessed maternal and perinatal outcomes in pregnant women with type 1 diabetes, treated with continuous subcutaneous insulin infusion and real time continuous glucose monitoring.
  
  
  METHODS
  This is a retrospective study, analyzing the basal characteristics, glycemic control, maternal and perinatal outcomes of pregnant women with type 1 diabetes, who were on an insulin pump with continuous glucose monitoring between 2011 and 2015.
  
  
  RESULTS
  Fourteen patients were included. The median age was 33 and disease duration 12 years. Indications for therapy were mainly poor glycemic control and severe hypoglycemia. The median A1c decrease was 1.02% between the first and third trimester. Pregnancies were associated with complications: 7.1% of the patients had diabetic ketoacidosis, 7.1% had an abortion, 28.5% gestational hypertension and 12.2% preeclampsia. The median gestational age at birth was 37 weeks and four days; the frequency of preterm birth was 7.1% and macrosomia 21.4%. There were no congenital malformations or perinatal death.
  
  
  CONCLUSIONS
  Baseline characteristics and results of patients in this study were similar to those reported in the previous literature. Continuous subcutaneous insulin infusion with continuous glucose monitoring is an alternative treatment option for pregnant women with type 1 diabetes before or during pregnancy.
authors.affiliation: a Department of Obstetrics and Gynecology , Universidad Pontificia Bolivariana , Medellín , Colombia.
authors.forename: Mónica
authors.initials: M
authors.lastname: Restrepo-Moreno
authors.affiliation: b Endocrinology, Universidad Pontificia Bolivariana, Clínica Integral de Diabetes, IDEA Investigation Group , Medellín , Colombia.
authors.forename: Alex
authors.initials: A
authors.lastname: Ramírez-Rincón
authors.affiliation: c Clinical Pharmacology , Clínica Integral de Diabetes, IDEA Investigation Group, PYPF Investigation Group Universidad de Antioquia , Medellín , Colombia.
authors.forename: Jaime
authors.initials: J
authors.lastname: Hincapié-García
authors.affiliation: b Endocrinology, Universidad Pontificia Bolivariana, Clínica Integral de Diabetes, IDEA Investigation Group , Medellín , Colombia.
authors.forename: Andrés
authors.initials: A
authors.lastname: Palacio
authors.affiliation: b Endocrinology, Universidad Pontificia Bolivariana, Clínica Integral de Diabetes, IDEA Investigation Group , Medellín , Colombia.
authors.forename: Claudia
authors.initials: C
authors.lastname: Monsalve-Arango
authors.affiliation: b Endocrinology, Universidad Pontificia Bolivariana, Clínica Integral de Diabetes, IDEA Investigation Group , Medellín , Colombia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Aristizabal-Henao
authors.affiliation: d Universidad CES, IDEA Investigation Group , Medellín , Colombia.
authors.forename: Camila
authors.initials: C
authors.lastname: Restrepo-Zapata
authors.affiliation: b Endocrinology, Universidad Pontificia Bolivariana, Clínica Integral de Diabetes, IDEA Investigation Group , Medellín , Colombia.
authors.forename: José Fernando
authors.initials: JF
authors.lastname: Botero-Arango
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015190:Blood Glucose Self-Monitoring / Q000379:methods*; D002585:Cesarean Section; D003105:Colombia; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology; D005865:Gestational Age; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000209:etiology; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D015918:Infusion Pumps, Implantable; D055104:Infusions, Subcutaneous; D007328:Insulin / Q000008:administration & dosage*; D007332:Insulin Infusion Systems; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin
keywords: Type 1 diabetes; continuous insulin infusion system; pregnancy