title: Defining the biology of intrahepatic cholangiocarcinoma: molecular pathways and early detection of precursor lesions.
abstract: Intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor of the biliary tract with growing incidence and dismal prognosis. It is responsible for 10-20% of primary liver cancer worldwide, but early diagnosis is still a challenge and few treatment options are available. Aim of this review is to summarize the current knowledge about biological features and arising molecular patterns of this disease. The identification of emerging biomarkers and early detection of precursor lesions shall play a key role in the perspective of future tailored targeted therapies.
authors.affiliation: Medical Pathology, Department of Internal Medicine, Gastroenterology Division, Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Rome, Italy. giulia.gibiino@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Gibiino
authors.forename: C
authors.initials: C
authors.lastname: Fabbri
authors.forename: S
authors.initials: S
authors.lastname: Fagiuoli
authors.forename: G
authors.initials: G
authors.lastname: Ianiro
authors.forename: A
authors.initials: A
authors.lastname: Fornelli
authors.forename: V
authors.initials: V
authors.lastname: Cennamo
mesh_terms: D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D014408:Biomarkers, Tumor; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000473:pathology*; D055088:Early Detection of Cancer; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor