title: Rare case of vascular malformations in both skin and brain: Case report and published work review.
abstract: Solitary venous malformation (VM) of the skin, previously known as cavernous hemangioma, is frequently observed in the dermatological field, but multiple acquired VM are rare. We present a case of multiple VM of the skin associated with multiple cerebral cavernous malformations (CCM) in a 70-year-old Japanese woman. In addition, we summarize seven reported similar cases, including the present case. That some reports have described concomitant VM of the skin and CCM, together with the present case, suggests a tight relationship or a common pathogenetic pathway between these two diseases.
authors.affiliation: Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.|Division of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Oka
authors.affiliation: Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.|Division of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Sakaguchi
authors.affiliation: Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fukumoto
authors.affiliation: Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Shin-Ichiro
authors.initials: SI
authors.lastname: Seki
authors.affiliation: Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Chikako
authors.initials: C
authors.lastname: Nishigori
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D062109:Dermatologic Surgical Procedures; D005260:Female; D020786:Hemangioma, Cavernous, Central Nervous System / Q000150:complications / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D006987:Hypesthesia / Q000209:etiology; D008279:Magnetic Resonance Imaging; D010146:Pain / Q000209:etiology; D035583:Rare Diseases / Q000150:complications / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D012867:Skin / Q000000981:diagnostic imaging / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000601:surgery; D040521:Subcutaneous Tissue / Q000002:abnormalities / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D060726:Torso / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D034941:Upper Extremity / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery
keywords: cavernous hemangioma; cerebral cavernous malformations; magnetic resonance imaging; neurological symptom; venous malformation