title: Downregulation of Rab23 in Prostate Cancer Inhibits Tumor Growth In Vitro and In Vivo.
abstract: Rab23, a novel member of the Rab GTPase family, was found to be implicated in the progression of some human cancers. However, what role Rab23 plays in prostate cancer (PCa) remains to be illustrated. In the present study, we investigated the expression pattern and roles of Rab23 in PCa. The study results showed that Rab23 was upregulated in PCa tissues and cell lines. Moreover, downregulation of Rab23 remarkably suppressed the proliferation, migration, and invasion of PCa cells. In addition, downregulation of Rab23 significantly downregulated the protein expression levels of Shh and Gli1. Furthermore, we found that the Gli1 inhibitor GANT-61 greatly enhanced the suppressive effect of Rab23 downregulation on PCa cells. In conclusion, we suggested Rab23 as a potential therapeutic target for PCa treatment.
authors.affiliation: Department of Urology, Huaihe Hospital of Henan University, Kaifeng, Henan Province, P.R. China.
authors.forename: Junkai
authors.initials: J
authors.lastname: Chang
authors.forename: Weibo
authors.initials: W
authors.lastname: Xu
authors.forename: Guangchao
authors.initials: G
authors.lastname: Liu
authors.forename: Xinyi
authors.initials: X
authors.lastname: Du
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000502:physiology; D015536:Down-Regulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011897:Random Allocation; D023041:Xenograft Model Antitumor Assays / Q000379:methods; D020691:rab GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C486614:RAB23 protein, human; D020691:rab GTP-Binding Proteins