title: Controlling Helix Sense at N- and C-Termini in Quinoline Oligoamide Foldamers by β-Pinene-Derived Pyridyl Moieties.
abstract: A series of quinoline oligoamide foldamers bearing a β-pinene-derived pyridyl group at the N-terminus or the C-terminus were synthesized, and the efficiencies of chiral inductions have been evaluated by1H NMR and CD spectra. The chiral inductions were quantitative when chiral pyridyl acid was appended at the N-terminus, but were inferior when chiral pyridyl amine was appended at the C-terminus. Unexpectedly, N-oxidation on the pyridine ring at the C-terminus does not notably enhance the chiral induction efficiency in spite of the presence of three-center hydrogen bonds.
authors.affiliation: Key Laboratory of Radiopharmaceuticals and Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Radiopharmaceuticals and Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Zhan
authors.affiliation: Key Laboratory of Radiopharmaceuticals and Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
authors.forename: Chengyuan
authors.initials: C
authors.lastname: Yu
authors.affiliation: Key Laboratory of Radiopharmaceuticals and Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.|Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Fu
authors.initials: F
authors.lastname: Huang
authors.affiliation: Key Laboratory of Radiopharmaceuticals and Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
authors.forename: Ying
authors.identifier: 0000-0002-7015-7228
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory of Radiopharmaceuticals and Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
authors.forename: Hua
authors.identifier: 0000-0002-9917-2683
authors.initials: H
authors.lastname: Jiang