title: PM2.5Exposure Suppresses Dendritic Maturation in Subgranular Zone in Aged Rats.
abstract: Detrimental effects of long-term inhalation of fine particulate matter (PM2.5) on the pulmonary and cardiovascular systems have been widely reported. Recent studies have shown that exposure to PM2.5also causes adverse neurocognitive effects. This study investigates the effects of inhaled ammonium sulfate, which is a major compound of inorganic air pollutants in PM2.5, on adult neurogenesis in aged Sprague-Dawley rats. A total of 20 rats were randomly assigned to experimental (n = 10) and control (n = 10) conditions, wherein they were exposed to either ammonium sulfate or sham air for 2 h per day and for 28 consecutive days. It was observed that ammonium sulfate inhibited the maturation process and diminished dendritic complexity of immature neurons in the subgranular zone (SGZ) of the hippocampus significantly, although the number of neural stem cells or the rates of differentiation were comparable between the two groups. Our findings provide clear evidence on the direct relationship between air quality and advantageous neurogenesis. Exposure to PM leads to specific adverse effects on the maturation process during neurogenesis.
authors.affiliation: The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong.|Laboratory of Cognitive Affective Neuroscience, The University of Hong Kong, Pokfulam, Hong Kong.|Laboratory of Neuropsychology, The University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Lewis
authors.initials: L
authors.lastname: Cheng
authors.affiliation: The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong.|Laboratory of Cognitive Affective Neuroscience, The University of Hong Kong, Pokfulam, Hong Kong.|Laboratory of Neuropsychology, The University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Way K W
authors.initials: WKW
authors.lastname: Lau
authors.affiliation: Applied Cognitive Neuroscience Laboratory, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Timothy K H
authors.initials: TKH
authors.lastname: Fung
authors.affiliation: Applied Cognitive Neuroscience Laboratory, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Benson W M
authors.initials: BWM
authors.lastname: Lau
authors.affiliation: Applied Cognitive Neuroscience Laboratory, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Bolton K H
authors.initials: BKH
authors.lastname: Chau
authors.affiliation: Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Yutong
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.affiliation: The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong.|Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, China.|Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Kwok Fai
authors.initials: KF
authors.lastname: So
authors.affiliation: Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Applied Cognitive Neuroscience Laboratory, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. chetwyn.chan@polyu.edu.hk.
authors.forename: Chetwyn C H
authors.initials: CCH
authors.lastname: Chan
authors.affiliation: The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong. tmclee@hku.hk.|Laboratory of Cognitive Affective Neuroscience, The University of Hong Kong, Pokfulam, Hong Kong. tmclee@hku.hk.|Laboratory of Neuropsychology, The University of Hong Kong, Pokfulam, Hong Kong. tmclee@hku.hk.|Institute of Clinical Neuropsychology, The University of Hong Kong, Pokfulam, Hong Kong. tmclee@hku.hk.
authors.forename: Tatia M C
authors.initials: TMC
authors.lastname: Lee
mesh_terms: D000280:Administration, Inhalation; D000375:Aging / Q000187:drug effects*; D000645:Ammonium Sulfate / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000473:pathology*; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002552:Cerebral Ventricles / Q000166:cytology; D003712:Dendrites / Q000187:drug effects*; D000089622:Doublecortin Domain Proteins; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D055495:Neurogenesis / Q000187:drug effects; D009474:Neurons / Q000648:ultrastructure*; D009479:Neuropeptides / Q000378:metabolism; D052638:Particulate Matter / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D052638:Particulate Matter; D001973:Bromodeoxyuridine; D000645:Ammonium Sulfate
keywords: Air pollution; Ammonium sulfate; Dendritic complexity; Fine particulate matter; Neurogenesis