title: Feasibility of catheter ablation renal denervation in "mild" resistant hypertension.
abstract: Renal denervation (RDN) has been proposed as a novel interventional antihypertensive technique. However, existing evidence was mainly from patients with severe resistant hypertension. The authors aimed to evaluate the efficacy of RDN in patients with resistant hypertension with mildly elevated blood pressure (BP). Studies of RDN in patients with mild resistant hypertension (systolic office BP 140-160 mm Hg despite treatment with three antihypertensive drugs including one diuretic, or mean systolic BP by 24-hour ambulatory BP measurement [ABPM] 135-150 mm Hg) were included. Two observational and one randomized cohort were identified (109 patients in the RDN group and 36 patients in the control group). Overall, the mean age of patients was 62±10 years, and 69.7% were male. Before-after comparison showed that RDN significantly reduced ABPM as compared with the baseline systolic ABPM, from 146.3±13 mm Hg at baseline to 134.6±14.7 mm Hg at 6-month follow-up and diastolic ABPM from 80.8±9.4 mm Hg at baseline to 75.5±9.8 mm Hg at 6-month follow up (both P<.001). This significant effect was not observed in the control group. Between-group comparison showed a greater change in ABPM in the RDN group as compared with that in the control group (change in systolic ABPM: -11.7±9.9 mm Hg in RDN vs -3.5±9.6 mm Hg in controls [P<.001]; change in diastolic ABPM: -5.3±6.3 mm Hg in RDN vs -2.1±5.5 mm Hg in control [P=.007]). RDN was also associated with a significantly decreased office systolic/diastolic BP and reduced number of antihypertensive medications. No severe adverse events were found during follow-up. RDN seems feasible to treat patients with mild resistant hypertension.
authors.affiliation: Evidence-Based Medicine, Department of Cardiology, Shanghai General Hospital, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Collaborative Postdoc Program Project on Renal Denervation (CPPP-RDN), Pacemed, Rio de Janeiro, Brazil.|Fellowship EHRA/ESC, Academic Teaching Center, Department of Cardiology, Allgemein öffentliches Krankenhaus Elisabethinen Linz / Elisabethinen University Teaching Hospital of Medical University Innsbruck and Vienna, Linz, Oberösterreich, Austria.
authors.forename: Shaojie
authors.initials: S
authors.lastname: Chen
authors.affiliation: Collaborative Postdoc Program Project on Renal Denervation (CPPP-RDN), Pacemed, Rio de Janeiro, Brazil.|Cardiac Surgery and Artificial Cardiac Stimulation Division, Department of Medicine, Hospital e Clínica São Gonçalo, Rio de Janeiro, Brazil.|Department of Medicine, Universidade Federal Fluminense, Rio de Janeiro, Brazil.
authors.forename: Marcio Galindo
authors.initials: MG
authors.lastname: Kiuchi
authors.affiliation: Department of Cardiology, AZ Delta, Roeselare, Belgium.
authors.forename: Willem-Jan
authors.initials: WJ
authors.lastname: Acou
authors.affiliation: Department of Cardiology, Allgemein öffentliches Krankenhaus Elisabethinen Linz / Elisabethinen University Teaching Hospital of Medical University Innsbruck and Vienna, Linz, Oberösterreich, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Derndorfer
authors.affiliation: Humanmedzin, Universität Leipzig, Leipzig, Germany.
authors.forename: Jiazhi
authors.initials: J
authors.lastname: Wang
authors.affiliation: Abteilung der Kardiologie, Herzzentrum Leipzig, Leipzig, Germany.
authors.forename: Ruotian
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Cardiology, Allgemein öffentliches Krankenhaus Elisabethinen Linz / Elisabethinen University Teaching Hospital of Medical University Innsbruck and Vienna, Linz, Oberösterreich, Austria.
authors.forename: Georgios
authors.initials: G
authors.lastname: Kollias
authors.affiliation: Department of Cardiology, Allgemein öffentliches Krankenhaus Elisabethinen Linz / Elisabethinen University Teaching Hospital of Medical University Innsbruck and Vienna, Linz, Oberösterreich, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Martinek
authors.affiliation: Hospital Regional Darcy Vargas, Rio Bonito, RJ, Brazil.
authors.forename: Tetsuaki
authors.initials: T
authors.lastname: Kiuchi
authors.affiliation: Department of Cardiology, Allgemein öffentliches Krankenhaus Elisabethinen Linz / Elisabethinen University Teaching Hospital of Medical University Innsbruck and Vienna, Linz, Oberösterreich, Austria.
authors.forename: Helmut
authors.initials: H
authors.lastname: Pürerfellner
authors.affiliation: Department of Cardiology, Shanghai General Hospital / Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Shaowen
authors.initials: S
authors.lastname: Liu
mesh_terms: D000368:Aged; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000601:surgery*; D007668:Kidney / Q000294:innervation* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013562:Sympathectomy / Q000379:methods*
keywords: blood pressure; prevention; renal denervation; resistant hypertension