title: The left middle temporal gyrus in the middle of an impaired social-affective communication network in social anxiety disorder.
abstract: Previous studies on patients diagnosed with social anxiety disorder (SAD) reported changed patterns of the resting-state functional connectivity network (rs-FCN) between the prefrontal cortices and other prefrontal, amygdalar or striatal regions. Using a graph theory approach, this study explored the modularity-based community profile and patterns of inter-/intra-modular communication for the rs-FCN in SAD.
  
  
  
  In total, for 28 SAD patients and 27 healthy controls (HC), functional magnetic resonance imaging (fMRI) data were acquired in resting-state and subjected to a graph theory analysis.
  
  
  
  The within-module degree z-score for a hub region [out of a total of 10 hub regions ranked using the participation coefficient] named left middle temporal gyrus was impaired in SAD compared to HC, proportional to the severity of clinician-scored and patient-reported functional impairment in SAD.
  
  
  
  Most of participants included in this study were undergraduate students in their early-to-mid 20's.
  
  
  
  This study showed the importance of functional communication from the left middle temporal gyrus with other opercular-insular-subcortical regions for better objective functioning and lesser subjective disability in SAD.
authors.affiliation: Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: Je-Yeon
authors.initials: JY
authors.lastname: Yun
authors.affiliation: Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jae-Chang
authors.initials: JC
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, Keimyung University, Daegu, Republic of Korea.
authors.forename: Jeonghun
authors.initials: J
authors.lastname: Ku
authors.affiliation: Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: Jung-Eun
authors.initials: JE
authors.lastname: Shin
authors.affiliation: Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jae-Jin
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry, Seoul National University College of Medicine and Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. Electronic address: soohchoi@snu.ac.kr.
authors.forename: Soo-Hee
authors.initials: SH
authors.lastname: Choi
mesh_terms: D000328:Adult; D000679:Amygdala / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000503:physiopathology; D003342:Corpus Striatum / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000072861:Phobia, Social / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology; D013702:Temporal Lobe / Q000503:physiopathology*
keywords: Graph theory; Intra-modular communication; Left middle temporal gyrus; Resting state functional connectivity; Social anxiety disorder; Social-affective communication network