title: Phenolic compounds from the stems of Flickingeria fimbriata.
abstract: Chemical investigation of Flickingeria fimbriata (Bl.) Hawkes (Orchidaceae) resulted in the isolation and identification of one new dihydrophenanthrene, 1,2,5,6,7-pentamethoxy-9,10-dihydrophenanthrene (1), together with seven known dihydrophenanthrenes, erianthridin (2), coelonin (3), 4-methoxy-9,10-dihydrophenanthrene-1,2,7-triol (4), lusianthridin (5), ephemeranthol A (6), flavanthridin (7) and hircinol (8), four known phenanthrenes, epheranthol B (9), nudol (10), denthyrsinin (11) and confusarin (12), and one known bibenzyl, batatasin III (13). The structure of the new compound was elucidated by spectroscopic analysis (HRMS, 1D and 2D NMR). All the compounds were isolated from F. fimbriata for the first time except for compounds 5 and 12, and compounds 1, 3, 4, 8, 10, 11 and 13 were obtained from this genus for the first time. Compounds 1-4 showed moderate cytotoxic activity against HepG2 cells.
authors.affiliation: a School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , P.R. China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Wu
authors.affiliation: a School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , P.R. China.
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Liu
authors.affiliation: a School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , P.R. China.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Zhong
authors.affiliation: a School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , P.R. China.
authors.forename: Yue-Juan
authors.initials: YJ
authors.lastname: Chen
authors.affiliation: a School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , P.R. China.
authors.forename: Dan-Na
authors.initials: DN
authors.lastname: Chen
authors.affiliation: a School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: He
authors.affiliation: a School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Jiang
mesh_terms: D001713:Biphenyl Compounds / Q000302:isolation & purification; D003603:Cytotoxins / Q000302:isolation & purification / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D029595:Orchidaceae / Q000737:chemistry*; D010616:Phenanthrenes / Q000302:isolation & purification; D010636:Phenols / Q000302:isolation & purification*; D018547:Plant Stems / Q000737:chemistry; D013267:Stilbenes / Q000302:isolation & purification
chemical_list: D001713:Biphenyl Compounds; D003603:Cytotoxins; D010616:Phenanthrenes; D010636:Phenols; D013267:Stilbenes; C504999:4-methoxy-9,10-dihydrophenanthrene-1,2,7-triol; C487941:batatasin-III; C468819:erianthridin; C505281:lusianthridin; C010574:biphenyl
keywords: 9,10-dihydrophenanthrene; Flickingeria fimbriata; Orchidaceae; cytotoxicity