title: Multisystem langerhans cell histiocytosis with thymic involvement diagnosed with anterior mediastinal mass in a 2-month-old boy.
abstract: Thymus gland involvement in Langerhans cell histiocytosis (LCH) is usually part of multi-system disease and may be more common than previously recognized. However, thymic involvement causing an anterior mediastinal mass is an extremely rare presentation of multisystem LCH. Here we report a 2-month-old-boy admitted to hospital with a giant anterior mediastinal mass with multisystem LCH involving the thymus, lungs, liver and skin. The differential diagnosis of mediastinal mass in children should also include LCH, especially multisystem disease. LCH should also be kept in mind in the differential diagnosis of skin lesions in infants, even if spontaneous regression occurs.
authors.affiliation: Division of Pediatric Oncology, Department of Pediatrics and Departments of Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Tekkeşin
authors.affiliation: Division of Pediatric Oncology, Department of Pediatrics and Departments of Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Okur
authors.affiliation: Division of Radiology, Department of Pediatrics and Departments of Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Betül Emine
authors.initials: BE
authors.lastname: Derinkuyu
authors.affiliation: Division of Pathology, Department of Pediatrics and Departments of Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Nalan
authors.initials: N
authors.lastname: Akyürek
authors.affiliation: Division of Pediatric Oncology, Department of Pediatrics and Departments of Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Oğuz
authors.affiliation: Division of Pediatric Oncology, Department of Pediatrics and Departments of Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Ceyda
authors.initials: C
authors.lastname: Karadeniz
authors.affiliation: Division of Pediatric Oncology, Department of Pediatrics and Departments of Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Faruk Güçlü
authors.initials: FG
authors.lastname: Pınarlı
mesh_terms: D003937:Diagnosis, Differential; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis*; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D008477:Mediastinal Diseases / Q000175:diagnosis*; D013950:Thymus Gland / Q000473:pathology*; D014057:Tomography, X-Ray Computed
keywords: Langerhans cell histiocytosis; infant; skin; thymus