title: Predictors of metabolic syndrome in first manic episode.
abstract: OBJECTIVE
  In the present study we aimed to investigate, whether an association between metabolic syndrome (MetS) and clinical features and affective temperaments exists or not in first manic episode of bipolar disorder (BD) and to clarify the prevalence and predictors of MetS.
  
  
  METHODS
  A total of 150 patients who were received a diagnosis of bipolar disorder type I according to DSM-IV criteria and who were experiencing their first manic episode (FME) were screened consecutively for inclusion. NCEP ATP III formulated an operational definition of MetS based on the presence of three or more of the following characteristics: abdominal obesity (waist circumference), hypertriglyceridemia, low HDL or being on an antilipidemic agent, high blood pressure or being on an antihypertensive agent, and fasting hyperglycemia or being on antiglycemic agent. The patients who had been in remission period for at least 8 weeks were evaluated with SKIP-TURK and TEMPS-A. Remission was defined as YMRS score <5.
  
  
  RESULTS
  37 (32.5%) patients had a MetS. Previous depressive episode, seasonality, negative family history and childhood trauma are determined as the predictors of MetS. Anxious and irritable temperament scores were higher in MetS (+) patients.
  
  
  CONCLUSIONS
  According to our results, links between MetS and BD may also have been predicted by genetic and environmental factors.
authors.affiliation: Üsküdar University, NPİstanbul Neuropsychiatry Hospital, İstanbul, Turkey. Electronic address: sermin.kesebir@uskudar.edu.tr.
authors.forename: Sermin
authors.initials: S
authors.lastname: Kesebir
authors.affiliation: Üsküdar University, NPİstanbul Neuropsychiatry Hospital, İstanbul, Turkey.
authors.forename: Boray
authors.initials: B
authors.lastname: Erdinç
authors.affiliation: Üsküdar University, NPİstanbul Neuropsychiatry Hospital, İstanbul, Turkey.
authors.forename: Nevzat
authors.initials: N
authors.lastname: Tarhan
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000453:epidemiology* / Q000523:psychology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000523:psychology; D015995:Prevalence; D011379:Prognosis; D013694:Temperament / Q000502:physiology*; D014421:Turkey / Q000453:epidemiology
keywords: Affective temperament; Bipolar disorder; First episode mania; Metabolic syndrome