title: [Au(pyb-H)(mnt)]: A novel gold(III) 1,2-dithiolene cyclometalated complex with antimicrobial activity (pyb-H=C-deprotonated 2-benzylpyridine; mnt=1,2-dicyanoethene-1,2-dithiolate).
abstract: The novel heteroleptic cyclometalated complex [AuIII(pyb-H)(mnt)] (1; pyb-H=C-deprotonated 2-benzylpyridine; mnt =1,2-dicyanoethene-1,2-dithiolate) was tested against a panel of ten Gram positive (belonging to the Staphylococcus, Streptococcus spp. and Bacillus clausii), Gram negative (E. coli, K. pneumoniae, P. aeruginosa) bacteria and three yeasts belonging to the Candida spp. Complex 1 showed a remarkable bacteriostatic antimicrobial activity against staphylococci, with Minimum Inhibitory Concentration (MIC) values of 1.56 and 3.13μg/mL for S. haemoliticus and S. aureus, respectively. Spectroscopic and electrochemical measurements, supported by Density Functional Theory (DFT) calculations, were exploited to fully investigate the electronic structure of complex 1 and its relationship with the antimicrobial activity.
authors.affiliation: Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, S.S. 554 bivio per Sestu, 09042 Monserrato, Cagliari, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Pintus
authors.affiliation: Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, S.S. 554 bivio per Sestu, 09042 Monserrato, Cagliari, Italy.
authors.forename: M Carla
authors.initials: MC
authors.lastname: Aragoni
authors.affiliation: Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Cinellu
authors.affiliation: Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Maiore
authors.affiliation: Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Isaia
authors.affiliation: Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, S.S. 554 bivio per Sestu, 09042 Monserrato, Cagliari, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Lippolis
authors.affiliation: Dipartimento di Scienze Chirurgiche, Università degli Studi di Cagliari, via Ospedale 40, 09124 Cagliari, Italy.
authors.forename: Germano
authors.initials: G
authors.lastname: Orrù
authors.affiliation: Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, S.S. 554 bivio per Sestu, 09042 Monserrato, Cagliari, Italy; Dipartimento di Scienze Chirurgiche, Università degli Studi di Cagliari, via Ospedale 40, 09124 Cagliari, Italy.
authors.forename: Enrica
authors.initials: E
authors.lastname: Tuveri
authors.affiliation: Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Zucca
authors.affiliation: Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, S.S. 554 bivio per Sestu, 09042 Monserrato, Cagliari, Italy. Electronic address: marca@unica.it.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Arca
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000254:growth & development*; D002175:Candida / Q000254:growth & development*; D050607:Organogold Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D050607:Organogold Compounds
keywords: Antimicrobic; Biofilm; Cyclometalation; DFT; Dithiolene; Gold