title: Evaluation of the Capability of Ionic Liquid-Amino Acid Aqueous Systems for the Formation of Aqueous Biphasic Systems and Their Applications in Extraction.
abstract: To obtain further experimental evidence for a better understanding of the molecular mechanisms responsible for the soluting-out effect phenomena in ternary systems composed of an ionic liquid (IL), amino acid, and water, systematic studies on the vapor-liquid, liquid-liquid, and solid-liquid equilibrium behavior of aqueous solutions of several ILs were carried out in the presence of a range of amino acids. Water activities for binary and ternary aqueous solutions containing 1-butyl-3-methylimidazolium chloride, [C4mim]Cl, 1-hexyl-3-methylimidazolium chloride, [C6mim]Cl, 1-butyl-3-methyl-imidazolium trifluoromethanesulfonate, [C4mim][CF3SO3], l-Ser, Gly, Ala, and l-Pro were measured using both vapor pressure osmometry and isopiestic methods. All of the ternary IL + amino acid + water systems show negative deviations from semi-ideal behavior and therefore soluting-out effects have been observed in these systems. In the case of the [C4mim][CF3SO3] + amino acids aqueous systems, the IL is soluted-out by the amino acids and the soluting-out effect appears by aqueous biphasic system formation. For these systems, the phase diagram and partition coefficient of caffeine were measured at 298.15 K. However, for the [C4mim]Cl and [C6mim]Cl containing systems, the amino acids are soluted-out by the ILs and the soluting-out effect appears by precipitation of the amino acids from the solution, and the solubilities of the amino acids in the aqueous solutions decrease in the presence of [C4mim]Cl and [C6mim]Cl.
authors.affiliation: Department of Chemistry, University of Kurdistan , Sanandaj 66177-15177, Iran.
authors.forename: Sajjad
authors.initials: S
authors.lastname: Noshadi
authors.affiliation: Department of Chemistry, University of Kurdistan , Sanandaj 66177-15177, Iran.
authors.forename: Rahmat
authors.identifier: 0000-0002-5560-5993
authors.initials: R
authors.lastname: Sadeghi