title: Clinical Value of Combined Detection of CK-MB, MYO, cTnI and Plasma NT-proBNP in Diagnosis of Acute Myocardial Infarction.
abstract: BACKGROUND
  Acute myocardial infarction (AMI) is a serious life-threatening and common heart disease that is based on coronary atherosclerosis. The aim is to study the changes in the level of kinase isoenzyme (CK-MB), myoglobin (MYO), cardiac troponin I (cTnI), and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with acute myocardial infarction (AMI) and the four indicators of joint detection clinical value for diagnosis of AMI.
  
  
  METHODS
  Plasma NT-proBNP, CK-MB, MYO, and cTnI were detected by CLIA in 208 AMI patients (AMI group) and 115 non-AMI patients (control group). SPSS 19.0 software was used to analyze the data.
  
  
  RESULTS
  The concentrations of CK-MB, MYO, cTnI, and NT-proBNP show significant differences between these two groups. In the AMI group, a significantly positive correlation was found between CK-MB and each of MYO and cTnI (r = 0.537, r = 0.226). Meanwhile, the sensitivity of combined detection has been improved up to 92.79%.
  
  
  CONCLUSIONS
  Therefore, these results suggested that detecting CK-MB, MYO, cTnI, and plasma NT-proBNP levels together can significantly contribute to the early diagnosis of AMI. It can also provide diagnostic evidence to clinic and thus lower the mortality of AMI in acute phase.
authors.forename: Jiubo
authors.initials: J
authors.lastname: Fan
authors.forename: Ji
authors.initials: J
authors.lastname: Ma
authors.forename: Ning
authors.initials: N
authors.lastname: Xia
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Baoan
authors.initials: B
authors.lastname: Li
authors.forename: Haiju
authors.initials: H
authors.lastname: Liu
mesh_terms: D015415:Biomarkers; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; D006801:Humans; D009203:Myocardial Infarction; D009211:Myoglobin; D020097:Natriuretic Peptide, Brain; D010446:Peptide Fragments; D019210:Troponin I
chemical_list: D015415:Biomarkers; D009211:Myoglobin; D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form