title: Phytochemical analysis of the ethanolic extract of Agathis robusta (C. Moore ex F. Muell.) F.M. Bailey.
abstract: This work reports the phytochemical analysis of the ethanolic extract obtained from the leaves of Agathis robusta (C. Moore ex F. Muell.) F.M. Bailey. The methodology utilised during this study comprised classical chromatographic and spectroscopic techniques. Six compounds were identified: agathisflavone (1), 7″-O-methyl-agathisflavone (2), cupressuflavone (3), rutin (4), shikimic acid (5) and (2S)-1,2-Di-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-3-O-β-d-galactopyranosyl glycerol (6). These belong to four major classes of natural compounds: bi-flavonoids (1-3); diglycosidic flavonoids (4); cycloexen-carboxylic acids (5); glycerol-glycolipids (6). To the best of our knowledge, compounds (3-6) were identified for the first time in this study as constituents of A. robusta. Anyway, the majority of these compounds has chemotaxonomic relevance and is mostly in accordance with the current botanical classification of this species. Moreover, they also present several pharmacological properties among which, the antibacterial, anti-inflammatory and protective ones are the most important and may explain why this species is used in the ethno-medicinal field.
authors.affiliation: a Dipartimento di Chimica , Università di Roma 'La Sapienza' , Rome , Italy.
authors.forename: Alessandro
authors.identifier: http://orcid.org/0000-0003-1492-6739
authors.initials: A
authors.lastname: Venditti
authors.affiliation: b Dipartimento di Biologia Ambientale , Università di Roma 'La Sapienza' , Rome , Italy.
authors.forename: Claudio
authors.identifier: http://orcid.org/0000-0002-2968-5264
authors.initials: C
authors.lastname: Frezza
authors.affiliation: c Dipartimento di Chimica e Tecnologie del Farmaco , Università di Roma 'La Sapienza' , Rome , Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Campanelli
authors.affiliation: b Dipartimento di Biologia Ambientale , Università di Roma 'La Sapienza' , Rome , Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Foddai
authors.affiliation: a Dipartimento di Chimica , Università di Roma 'La Sapienza' , Rome , Italy.
authors.forename: Armandodoriano
authors.identifier: http://orcid.org/0000-0001-8622-5742
authors.initials: A
authors.lastname: Bianco
authors.affiliation: b Dipartimento di Biologia Ambientale , Università di Roma 'La Sapienza' , Rome , Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Serafini
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification; D000893:Anti-Inflammatory Agents / Q000032:analysis / Q000302:isolation & purification; D000431:Ethanol / Q000032:analysis; D005419:Flavonoids / Q000032:analysis / Q000302:isolation & purification; D006017:Glycolipids / Q000032:analysis / Q000302:isolation & purification; D064209:Phytochemicals / Q000032:analysis*; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D064028:Tracheophyta / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D006017:Glycolipids; D064209:Phytochemicals; D010936:Plant Extracts; D000431:Ethanol
keywords: Agathis robusta (C. Moore ex F. Muell.) F.M. Bailey; biflavonoids; chemotaxonomy; ethno-pharmacology; phytochemical analysis