title: Regulating Damage from Sterile Inflammation: A Tale of Two Tolerances.
abstract: The severity of immunopathology from non-infectious inflammation is mainly understood and is managed by targeting immune cells. However, the role of target tissues in determining damage severity has been largely overlooked. Here, we discuss the concept of 'tissue tolerance' for tissue-intrinsic programs that ameliorate organ damage in the setting of sterile immunopathology.
authors.affiliation: Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
authors.forename: Shin-Rong
authors.initials: SR
authors.lastname: Wu
authors.affiliation: Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA. Electronic address: reddypr@umich.edu.
authors.forename: Pavan
authors.initials: P
authors.lastname: Reddy
mesh_terms: D000818:Animals; D015551:Autoimmunity; D060833:Cellular Microenvironment; D006801:Humans; D007108:Immune Tolerance; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007167:Immunotherapy / Q000639:trends*; D007249:Inflammation / Q000276:immunology*; D018448:Models, Immunological; D009928:Organ Specificity