title: [Drug release from electrospun simvastatin/polycaprolactone fibrous membranes].
abstract: OBJECTIVE
  To prepare electrospun simvastatin/polycaprolactone(SMV/PCL) membrane scaffolds and to evaluate the release properties of this formulation.
  
  
  METHODS
  Electrospun SMV/PCL membrane scaffolds were prepared as the experimental group, and electrospun PCL membrane as the control group. The morphology and characteristics of membrane surface were determined by scanning electron microscopic(SEM) and X-ray diffraction(XRD). The release profile of SMV was determined using an ultraviolet-visible spectrometer. The data were analyzed statistically with SPSS 17.0 software package.
  
  
  RESULTS
  SEM and XRD indicated that SMV/PCL nanofibers were successfully electrospun and SMV was encapsulated into the fibers. In vitro drug release studies showed that simultaneous SMV release, being nearly linear with time, was achieved and sustained SMV release was prolonged to 28 days.
  
  
  CONCLUSIONS
  Electrospun SMV/PCL nanofiber membranes demonstrate sustained drug release properties, suggesting their potential applicability as prospective scaffolds in periodontal regeneration.
authors.affiliation: Department of Orthodontics, Shanghai Stomatological Hospital. Shanghai 200031, China. E-mail:zhaobingjiao@sina.com.
authors.forename: Bing-Jiao
authors.initials: BJ
authors.lastname: Zhao
authors.forename: Yao
authors.initials: Y
authors.lastname: Xu
authors.forename: Yue-Hua
authors.initials: YH
authors.lastname: Liu
mesh_terms: D003692:Delayed-Action Preparations; D065546:Drug Liberation; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry*; D011091:Polyesters / Q000032:analysis*; D011446:Prospective Studies; D012038:Regeneration; D019821:Simvastatin / Q000032:analysis*; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D014961:X-Ray Diffraction
chemical_list: D003692:Delayed-Action Preparations; D011091:Polyesters; C016240:polycaprolactone; D019821:Simvastatin