title: The maternal thiol/disulfide homeostasis does not change in pregnancies complicated by preterm prelabor rupture of membranes.
abstract: OBJECTIVE
  To evaluate the maternal thiol/disulfide homeostasis in pregnant women complicated by preterm prelabor rupture of membranes (PPROM) and to compare the results with healthy pregnancies.
  
  
  METHODS
  This cohort study consisted of thirty-nine pregnancies complicated by PPROM and 44 gestational age-matched healthy pregnancies in the third trimester of gestation. Maternal serum samples were obtained at the day of diagnosis, and thiol/disulfide profiles were measured by using an automated assay method. The patients were followed till delivery, and perinatal outcomes were noted.
  
  
  RESULTS
  The maternal native thiol (319.9 ± 30.5 μmol/L versus 305.1 ± 49.2 μmol/L, p: .100), total thiol (379.2 ± 38.8 μmol/L versus 363.6 ± 56.4 μmol/L, p: .142) and disulfide (29.7 ± 11.7 μmol/L versus 29.3 ± 10.1 μmol/L, p: .864) levels were similar between the groups. Maternal disulfide/native thiol, disulfide/total thiol and native thiol/total thiol ratios were similar between the groups (p: .610, p: .565 and .562, respectively). The maternal serum thiol/disulfide profiles were not significantly correlated with maternal serum C-reactive protein, white blood cell count values and ongoing pregnancy outcomes (p > .05).
  
  
  CONCLUSIONS
  The current study demonstrated that there was not any disturbance in maternal thiol/disulfide homeostasis in pregnancies complicated by PPROM at the time of initial diagnosis. Follow-up studies with larger sample size are needed to confirm our results.
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Orkun
authors.initials: O
authors.lastname: Cetin
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Erbil
authors.initials: E
authors.lastname: Karaman
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Boza
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Numan
authors.initials: N
authors.lastname: Cim
authors.affiliation: b Department of Biochemistry, Faculty of Medicine , Yıldırım Beyazıt University , Ankara , Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
authors.affiliation: b Department of Biochemistry, Faculty of Medicine , Yıldırım Beyazıt University , Ankara , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Alisik
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Kolusarı
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Yildizhan
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Hanım Guler
authors.initials: HG
authors.lastname: Sahin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D015331:Cohort Studies; D004220:Disulfides / Q000097:blood*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood* / Q000209:etiology; D006706:Homeostasis; D006801:Humans; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D015415:Biomarkers; D004220:Disulfides; D013438:Sulfhydryl Compounds; D002097:C-Reactive Protein
keywords: Preterm prelabor rupture of membranes; maternal serum; pregnancy; thiol/disulfide homeostasis