title: Data on the effect of hypomyelinating leukodystrophy 6 (HLD6)-associated mutations on the TUBB4A properties.
abstract: Hypomyelinating leukodystrophy (HLD) is genetic demyelinating or dysmyelinating disease and is associated with at least 13 responsible genes. The mutations seem likely cause the functional deficiency of their gene products. HLD4- and HLD5-associated HSPD1 and FAM126A mutations affect biochemical properties of the gene products (Miyamoto et al. (2015,2014) [[1], [2]]). Herein we provide the data regarding the effects of HLD6-associated tubulin beta 4A (TUBB4A) mutations on the properties.
authors.affiliation: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan; Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Miyamoto
authors.affiliation: Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Torii
authors.affiliation: Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Kawahara
authors.affiliation: Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, Minato, Tokyo 105-8512, Japan.
authors.forename: Nanami
authors.initials: N
authors.lastname: Hasegawa
authors.affiliation: Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.
authors.forename: Akito
authors.initials: A
authors.lastname: Tanoue
authors.affiliation: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Seki
authors.affiliation: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Morimoto
authors.affiliation: Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, Minato, Tokyo 105-8512, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Funakoshi-Tago
authors.affiliation: Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, Minato, Tokyo 105-8512, Japan.
authors.forename: Hiroomi
authors.initials: H
authors.lastname: Tamura
authors.affiliation: Department of Life Science and Informatics, Maebashi Institute of Technology, Maebashishi, Gunma 371-0816, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Homma
authors.affiliation: Tsumura Research Laboratories, Tsumura & Co., Inashiki, Ibaraki 200-1192, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan; Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Yamauchi
keywords: Biochemical property; Disease-associated mutation; HLD6; TUBB4A; Tubulin