title: Diagnostic performance of conventional MRI parameters and apparent diffusion coefficient values in differentiating between benign and malignant soft-tissue tumours.
abstract: OBJECTIVE
  To compare the abilities of conventional magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) in differentiating between benign and malignant soft-tissue tumours (STT).
  
  
  METHODS
  A total of 123 patients with STT who underwent 3 T MRI, including diffusion-weighted imaging (DWI), were retrospectively analysed using variate conventional MRI parameters, ADCmeanand ADCmin.
  
  
  RESULTS
  For the all-STT group, the correlation between the malignant STT conventional MRI parameters, except deep compartment involvement, compared to those of benign STT were statistically significant with univariate analysis. Maximum diameter of the tumour (p=0.001; odds ratio [OR], 8.97) and ADCmean(p=0.020; OR, 4.30) were independent factors with multivariate analysis. For the non-myxoid non-haemosiderin STT group, signal heterogeneity on axial T1-weighted imaging (T1WI; p=0.017), ADCmean, and ADCmin(p=0.001, p=0.001), showed significant differences with univariate analysis between malignancy and benignity. Signal heterogeneity in axial T1WI (p=0.025; OR, 12.64) and ADCmean(p=0.004; OR, 33.15) were independent factors with multivariate analysis.
  
  
  CONCLUSIONS
  ADC values as well as conventional MRI parameters were useful in differentiating between benign and malignant STT. The ADCmeanwas the most powerful diagnostic parameter in non-myxoid non-haemosiderin STT.
authors.affiliation: Department of Radiology, Hanyang University Hospital, Seoul, Republic of Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Y
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Electronic address: youngcheol.yoon@gmail.com.
authors.forename: Y C
authors.initials: YC
authors.lastname: Yoon
authors.affiliation: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Y
authors.initials: Y
authors.lastname: Chong
authors.affiliation: Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Seo
authors.affiliation: Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea; Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Y-L
authors.initials: YL
authors.lastname: Choi
authors.affiliation: Department of Biostatistics and Clinical Epidemiology Center, Samsung Medical Center, Seoul, Republic of Korea.
authors.forename: I
authors.initials: I
authors.lastname: Sohn
authors.affiliation: Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Republic of Korea.
authors.forename: M-J
authors.initials: MJ
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D055815:Young Adult