title: Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses.
abstract: The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease. In order to efficiently establish a productive infection in mammalian cells, flaviviruses have developed key strategies to counteract host immune defences, including the type I interferon response. They employ different mechanisms to control interferon signal transduction and effector pathways, and key research generated over the past couple of decades has uncovered new insights into their abilities to actively decrease interferon antiviral activity. Given the lack of antivirals or prophylactic treatments for many flaviviral infections, it is important to fully understand how these viruses affect cellular processes to influence pathogenesis and disease outcome. This review will discuss the strategies mosquito-borne flaviviruses have evolved to antagonise type I interferon mediated immune responses.
authors.affiliation: MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Cumberworth
authors.affiliation: MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK.
authors.forename: Jordan J
authors.initials: JJ
authors.lastname: Clark
authors.affiliation: MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK.
authors.forename: Alain
authors.initials: A
authors.lastname: Kohl
authors.affiliation: MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK.
authors.forename: Claire L
authors.identifier: 0000-0002-4370-0707
authors.initials: CL
authors.lastname: Donald
mesh_terms: D000818:Animals; D009033:Culicidae / Q000821:virology; D005416:Flavivirus / Q000502:physiology*; D018177:Flavivirus Infections / Q000276:immunology / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007303:Insect Vectors / Q000821:virology; D007370:Interferon Type I / Q000235:genetics* / Q000378:metabolism; D015533:Transcriptional Activation / Q000276:immunology; D017361:Viral Nonstructural Proteins / Q000502:physiology*
chemical_list: D007370:Interferon Type I; D017361:Viral Nonstructural Proteins
keywords: Flavivirus; interferon antagonists; sfRNA; type I interferon