title: Evaluation of a sublingual immunotherapy solution in olive-induced respiratory allergy in Jordan: a retrospective observational study.
abstract: BACKGROUND
  Olive pollen is an important cause of respiratory allergy in the Middle East. In this study, the clinical characteristics of adults and children with confirmed allergic rhinitis (AR; with or without asthma) in Jordan were described, and the use of sublingual immunotherapy (SLIT) in a real-life clinical setting was assessed.
  
  
  METHODS
  This retrospective observational study evaluated the clinical features of olive-induced allergy and the use of an SLIT solution of standardized extracts toward Ole e 1 given in a pre- and coseasonal scheme with a daily dose of 300 index of reactivity for two consecutive seasons. Inclusion criteria were as follows: ≥5 years of age, AR, proven olive sensitization, and at least 2 years follow-up after SLIT initiation. The following data were recorded at SLIT initiation: clinical characteristics, rhinitis and asthma symptom scores, and concomitant symptomatic medications. During follow-up and at the end of each season, the following data were recorded: symptom progression/scores, any changes to symptomatic medications, and treatment compliance. The secondary objective was to determine any effect on quality of life, use of concomitant AR medications, and treatment compliance.
  
  
  RESULTS
  Eighty-six patients with seasonal AR were included in this analysis (52.3% with coexisting asthma). Between the initiation of treatment and the end of second pollen season, symptoms of AR and asthma were decreased by 79.5% and 41.7%, respectively, with an improvement in quality of life score in 71.5% of the patients (P<0.0001 for all). Physicians reported that after 2 years of SLIT, there was an improvement in the symptoms of both AR (95.2%) and asthma (93.3%), with 98.8% of the patients showing good treatment compliance. A reduction in symptomatic medications was also found. SLIT was well tolerated with no systemic reactions being reported.
  
  
  CONCLUSIONS
  In children and adults with olive-associated respiratory allergy in Jordan, the use of a pre- and coseasonal SLIT with a 300 index of reactivity daily dose is effective in reducing the clinical burden of AR and asthma with no tolerability issues.
authors.affiliation: Private practice, Amman, Jordan.
authors.forename: Khaled
authors.initials: K
authors.lastname: Al-Asad
authors.affiliation: Private practice, Amman, Jordan.
authors.forename: Sayed
authors.initials: S
authors.lastname: Al-Nazer
authors.affiliation: Private practice, Amman, Jordan.
authors.forename: Anan
authors.initials: A
authors.lastname: Al-Faqih
authors.affiliation: Private practice, Amman, Jordan.
authors.forename: Mohammad Jamil
authors.initials: MJ
authors.lastname: Hashem
keywords: SLIT; allergen immunotherapy; effectiveness; olive pollen; patient satisfaction; rhinitis; tolerability