title: Analysis of the sleep EEG in the complexity domain.
abstract: Conventional sleep analysis relies primarily on electroencephalogram (EEG) waveform features assessed in concert with eye movements, respiration and muscle tone. We explore a complementary "complexity domain" approach based on multiscale entropy (MSE) analysis of EEG signals and discuss its relationships to standard sleep analysis and to that based on electrocardiogram (ECG)-derived cardiopulmonary coupling (CPC). We observe a progressive decrease in complexity associated with decreased arousability, as measured by both conventional sleep scoring and CPC analysis. Furthermore, complexity analysis supports the contention that stage 2 non-REM sleep has distinct sub-phases that map to CPC high- and low-frequency coupled dynamics.
authors.forename: Sara
authors.initials: S
authors.lastname: Mariani
authors.forename: Ana F T
authors.initials: AF
authors.lastname: Borges
authors.forename: Teresa
authors.initials: T
authors.lastname: Henriques
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Thomas
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Leistedt
authors.forename: Paul
authors.initials: P
authors.lastname: Linkowski
authors.forename: Jean-Pol
authors.initials: JP
authors.lastname: Lanquart
authors.forename: Ary L
authors.initials: AL
authors.lastname: Goldberger
authors.forename: Madalena D
authors.initials: MD
authors.lastname: Costa
mesh_terms: D000328:Adult; D004562:Electrocardiography; D004569:Electroencephalography; D019277:Entropy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012119:Respiration; D012815:Signal Processing, Computer-Assisted; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology; D014851:Wakefulness / Q000502:physiology