title: Cognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype.
abstract: The probable-amnestic (Pr-a) mild cognitive impairment (MCI)-storage subtype is a phenotype with 8.5 times more risk of conversion to dementia, mainly Alzheimer's disease (AD), than the possible non-amnestic (Pss-na) MCI. The aim of this study was to find the optimized cognitive composites (CCs) domain scores most related to neuroimaging biomarkers within Pr-aMCI-storage subtype patients. The Fundació ACE (ACE) study with 20 Pr-aMCI-storage subtype subjects (MCI) were analyzed. All subjects underwent a neuropsychological assessment, a structural MRI, FDG-PET, and PIB-PET. The adjusted hippocampal volume (aHV) on MRI, the standard uptake value ratio (SUVR) on FDG-PET and PIB-PET SUVR measures were analyzed. The construction of the CCs domain scores, and the aHV on MRI and FDG-PET SUVR measures, were replicated in the parental AB255 study database (n = 133 MCI). Partial correlations adjusted by age, gender, and education were calculated with the associated p-value among every CC domain score and the neuroimaging biomarkers. The results were replicated in the "MCI due to AD" with memory storage impairments from ADNI. Delayed Recall CC domain score was significantly correlated with PIB-PET SUVR (β= -0.61, p = 0.003) in the ACE study and also with aHV on MRI (β= 0.27, p = 0.01) and FDG-PET SUVR (β= 0.27, p = 0.01) in the AB255 study. After a median survival time of 20.6 months, 85% from the ACE MCI converted to AD. The replication of our results in the ADNI dataset also confirmed our findings. Delayed Recall is the CC domain score best correlated with neuroimaging biomarkers associated with prodromal AD diagnosis.
authors.affiliation: Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Alzheimer Barcelona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Espinosa
authors.affiliation: Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Alzheimer Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Alegret
authors.affiliation: Araclon Biotech S.L., Zaragoza, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Pesini
authors.affiliation: Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Alzheimer Barcelona, Spain.|Deparment of Psychiatry, Hospital Universitari Vall d'Hebron, CIBERSAM, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Sergi
authors.initials: S
authors.lastname: Valero
authors.affiliation: Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Alzheimer Barcelona, Spain.
authors.forename: Asunción
authors.initials: A
authors.lastname: Lafuente
authors.affiliation: Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Alzheimer Barcelona, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Buendía
authors.affiliation: Araclon Biotech S.L., Zaragoza, Spain.
authors.forename: Itziar
authors.initials: I
authors.lastname: San José
authors.affiliation: Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Alzheimer Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Ibarria
authors.affiliation: Clínica Corachán, Barcelona, Spain.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Tejero
authors.affiliation: Clínica Corachán, Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Giménez
authors.affiliation: Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Alzheimer Barcelona, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Ruiz
authors.affiliation: Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Alzheimer Barcelona, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Hernández
authors.affiliation: Department of Neurology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Pujadas
authors.affiliation: Fundación CITA, Centro de Investigación y Terapias Avanzadas, Alzheimer, San Sebastián, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Martínez-Lage
authors.affiliation: Hospital Universitari Germans Trias i Pujol, Unitat RM Badalona, Institut de diagnòstic per la imatge, Badalona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Munuera
authors.affiliation: Clínica Universitaria de Pamplona, Pamplona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Arbizu
authors.affiliation: Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Alzheimer Barcelona, Spain.
authors.forename: Lluis
authors.initials: L
authors.lastname: Tárraga
authors.affiliation: Pentara Corporation, Salt Lake City, UT, USA.
authors.forename: Suzanne B
authors.initials: SB
authors.lastname: Hendrix
authors.affiliation: Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Alzheimer Barcelona, Spain.
authors.forename: Agustín
authors.initials: A
authors.lastname: Ruiz
authors.affiliation: Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: James T
authors.initials: JT
authors.lastname: Becker
authors.affiliation: Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Landau
authors.affiliation: Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Alzheimer Barcelona, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Sotolongo-Grau
authors.affiliation: Araclon Biotech S.L., Zaragoza, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Sarasa
authors.affiliation: Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Alzheimer Barcelona, Spain.
authors.forename: Mercè
authors.initials: M
authors.lastname: Boada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism / Q000523:psychology; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000378:metabolism / Q000523:psychology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall; D059906:Neuroimaging; D009483:Neuropsychological Tests; D009929:Organ Size; D049268:Positron-Emission Tomography; D062706:Prodromal Symptoms; D019275:Radiopharmaceuticals; D016019:Survival Analysis; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D019275:Radiopharmaceuticals; D013844:Thiazoles; D019788:Fluorodeoxyglucose F18
keywords: Alzheimer’s disease; amnestic mild cognitive impairment; amyloid; cognition; hippocampus; magnetic resonance imaging; memory; positron emission tomography