title: Clinical value of hyperemic left ventricular systolic function in vasodilator stress testing.
abstract: Exercise results in increased left ventricular contractility in normal individuals. Similar changes can also be seen with vasodilator stress. This article discusses the physiologic basis of these changes as well as reviews the clinical data supporting the use of these parameters for diagnostic and prognostic evaluation. Methodologic limitations as well as other concomitant pathologic processes which may confound interpretation of stress-induced changes in LVEF are also reviewed.
authors.affiliation: Frankel Cardiovascular Center, University of Michigan, 1500 E. Medical Center Dr, Ann Arbor, MI, 48109-5873, USA. vlmurthy@med.umich.edu.
authors.forename: Venkatesh L
authors.initials: VL
authors.lastname: Murthy
authors.affiliation: Cardiovascular Imaging Program, Departments of Medicine and Radiology, Division of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA, 02115, USA.
authors.forename: Sharmila
authors.initials: S
authors.lastname: Dorbala
mesh_terms: D019317:Evidence-Based Medicine; D005080:Exercise Test / Q000187:drug effects* / Q000379:methods*; D006801:Humans; D006940:Hyperemia / Q000150:complications / Q000000981:diagnostic imaging*; D007089:Image Enhancement / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D014665:Vasodilator Agents / Q000008:administration & dosage*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology
chemical_list: D014665:Vasodilator Agents
keywords: A2A adenosine receptor agonists; Vasodilator stress; adenosine; dipyridamole; ejection fraction