title: Stable Titania Nanostructures on Stainless Steel Coronary Stent Surface for Enhanced Corrosion Resistance and Endothelialization.
abstract: Stainless steel (SS) coronary stents continue to present risk of in-stent restenosis that impact its long term safety and efficacy. The present work focuses on developing a drug-free and polymer-less surface on coronary stents by utilizing a titania (TiO2) nanotexturing approach through hydrothermal processing, that will offer improved stent performance in vivo. Mechanically stable and durable nanotextured coatings are obtained on SS stents that also offer good corrosion resistance. In vitro vascular cell (endothelial and smooth muscle cells) studies on surface modified SS show preferential rapid endothelialization with enhanced nitric oxide production and reduce smooth muscle cell proliferation, in comparison to unmodified SS. In vivo evaluation of the nanotextured stents after subcutaneous implantation in rabbits show reduced irritability and minimal localized inflammatory response. These beneficial effects suggest that the stable, easily scalable titania nanosurface modification strategy on coronary stent surfaces can be a much cheaper alternative to drug eluting stents in addressing in-stent restenosis.
authors.affiliation: Centre for Nanosciences & Molecular Medicine, Amrita University, Ponekkara P. O., Cochin, 682041, Kerala, India.
authors.forename: Chandini C
authors.initials: CC
authors.lastname: Mohan
authors.affiliation: Centre for Nanosciences & Molecular Medicine, Amrita University, Ponekkara P. O., Cochin, 682041, Kerala, India.
authors.forename: Aleena Mary
authors.initials: AM
authors.lastname: Cherian
authors.affiliation: Centre for Nanosciences & Molecular Medicine, Amrita University, Ponekkara P. O., Cochin, 682041, Kerala, India.
authors.forename: Sujish
authors.initials: S
authors.lastname: Kurup
authors.affiliation: Centre for Nanosciences & Molecular Medicine, Amrita University, Ponekkara P. O., Cochin, 682041, Kerala, India.
authors.forename: John
authors.initials: J
authors.lastname: Joseph
authors.affiliation: Centre for Nanosciences & Molecular Medicine, Amrita University, Ponekkara P. O., Cochin, 682041, Kerala, India.
authors.forename: Manitha B
authors.initials: MB
authors.lastname: Nair
authors.affiliation: Centre for Nanosciences & Molecular Medicine, Amrita University, Ponekkara P. O., Cochin, 682041, Kerala, India.
authors.forename: Maniyal
authors.initials: M
authors.lastname: Vijayakumar
authors.affiliation: Centre for Nanosciences & Molecular Medicine, Amrita University, Ponekkara P. O., Cochin, 682041, Kerala, India.
authors.forename: Shantikumar V
authors.initials: SV
authors.lastname: Nair
authors.affiliation: Centre for Nanosciences & Molecular Medicine, Amrita University, Ponekkara P. O., Cochin, 682041, Kerala, India.
authors.forename: Deepthy
authors.initials: D
authors.lastname: Menon
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003331:Coronary Vessels; D003343:Corrosion; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry*; D011817:Rabbits; D013193:Stainless Steel / Q000737:chemistry*; D015607:Stents; D014025:Titanium / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D013193:Stainless Steel; C009495:titanium dioxide; D014025:Titanium
keywords: corrosion resistance; durability; in vitro endothelialization; nanostructured TiO2