title: Reversal of direct oral anticoagulants.
abstract: An understanding of how to counteract the anticoagulant effect of direct oral anticoagulants is essential in the event of haemorrhage, emergency surgery and overdose. This review summarizes strategies for the reversal of direct oral anticoagulants, including the use of novel agents.
authors.affiliation: Haematology Specialist Registrar, Department of Haematology, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford.
authors.forename: X-Y
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Clinical Research Fellow, NHS Blood and Transplant, John Radcliffe Hospital, Oxford, and Oxford Clinical Research in Transfusion Medicine, Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford.
authors.forename: M J
authors.initials: MJ
authors.lastname: Desborough
authors.affiliation: Consultant Haematologist, Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 7LE.
authors.forename: S
authors.initials: S
authors.lastname: Shapiro
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000925:Anticoagulants / Q000009:adverse effects; D000931:Antidotes / Q000627:therapeutic use*; D000991:Antithrombins / Q000009:adverse effects*; D001120:Arginine / Q000031:analogs & derivatives / Q000627:therapeutic use; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D003029:Coagulants / Q000627:therapeutic use*; D000069604:Dabigatran / Q000009:adverse effects*; D015951:Factor Xa / Q000627:therapeutic use; D065427:Factor Xa Inhibitors / Q000009:adverse effects; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D020300:Intracranial Hemorrhages / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D010314:Partial Thromboplastin Time; D010879:Piperazines / Q000627:therapeutic use; D011517:Prothrombin Time; D011994:Recombinant Proteins / Q000627:therapeutic use; D013918:Thrombin Time
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000925:Anticoagulants; D000931:Antidotes; D000991:Antithrombins; D001779:Blood Coagulation Factors; D003029:Coagulants; D065427:Factor Xa Inhibitors; C580915:PRT064445; D010879:Piperazines; D011994:Recombinant Proteins; C025667:prothrombin complex concentrates; D001120:Arginine; C000594745:idarucizumab; D015951:Factor Xa; D000069604:Dabigatran; C000593571:PER977