title: Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review.
abstract: Esculetin, synonymous with 6,7-dihydroxycoumarin, is the main active ingredient of the traditional Chinese medicineCortex Fraxini. The twig skin or trunk bark ofCortex Fraxiniare used by herb doctors as a mild, bitter liver and gallbladder meridians' nontoxic drug as well as dietary supplement. Recently, with a variety of novel esculetin derivatives being reported, the molecular mechanism research as well as clinical application ofCortex Fraxiniand esculetin are becoming more attractive. This mini-review will consolidate what is known about the biological activities, the mechanism of esculetin and its synthetic derivatives over the past decade in addition to providing a brief synopsis of the properties of esculetin.
authors.affiliation: Faculty of Pharmacy, Shaanxi University of Science & Technology, 6 Xuefu Road, Xi'an 710021, China. chengyuanliang@gmail.com.
authors.forename: Chengyuan
authors.initials: C
authors.lastname: Liang
authors.affiliation: Faculty of Pharmacy, Shaanxi University of Science & Technology, 6 Xuefu Road, Xi'an 710021, China. juweihui11521@sina.com.
authors.forename: Weihui
authors.initials: W
authors.lastname: Ju
authors.affiliation: Faculty of Pharmacy, Shaanxi University of Science & Technology, 6 Xuefu Road, Xi'an 710021, China. huabienaiqiao@sina.com.
authors.forename: Shaomeng
authors.initials: S
authors.lastname: Pei
authors.affiliation: Xi'an Taikomed Pharmaceutical technology Co., LTD, Xi'an 710077, China. techno8833@taikomed.com.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Faculty of Finance and Economics, Guangzhou Vocational College of Science and Technology, Guangzhou 510550, China. lvyuecheng@126.com.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D004365:Drugs, Chinese Herbal; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D014468:Umbelliferones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D014468:Umbelliferones; C007628:esculetin
keywords: coumarin; esculetin; molecular mechanism; pharmacological activity; synthetic derivatives