title: [Possibility of uterus transplantation trial in Czech Republic - indications, research and clinical experience].
abstract: Uterus transplantation is a novel experimental method of female infertility treatment. It is an appropriate treatment modality for women with absolute uterine factor infertility - congenital uterine malformations, absent uterus, hysterectomized women and non-functional uterus.Successful animal studies confirming the safety and efficacy were performed before introduction of uterus transplantation into human medicine. The first clinical trial was performed in 2012-2013 in Gothenburg, Sweden. The first child from the transplanted womb was delivered in 2014. Concerning the promising results of Swedish trial it is essential to perform trials in some other world centers.In 2015 Czech Ministry of Health permitted uterus transplantation trial in cooperation of two Prague hospitals - namely Institute for Clinical and Experimental Medicine and University Hospital Motol. The aim of the Czech trial is to reassert feasibility, efficacy and safety of uterus transplantation in two groups of women - 10 recipients from living and 10 from deceased brain donor. We believe that detailed and precise long-term theoretic and practical preparation and perfectly arranged trial are the main conditions of the successful uterine transplantation survey. The first Czech uterus transplantation was performed in April 30, 2016.Up to December 2016 four transplantations out of planned 20 (2 in living donor and 2 in deceased brain donor arm) were carried out by our team.
authors.forename: Roman
authors.initials: R
authors.lastname: Chmel
authors.forename: Marta
authors.initials: M
authors.lastname: Nováčková
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Pastor
authors.forename: Jan
authors.initials: J
authors.lastname: Matěcha
authors.forename: Miloš
authors.initials: M
authors.lastname: Čekal
authors.forename: Jiří
authors.initials: J
authors.lastname: Froněk
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D018153:Czech Republic; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000601:surgery; D013548:Sweden; D014564:Urogenital Abnormalities / Q000601:surgery; D014599:Uterus / Q000637:transplantation
keywords: infertility sterility.; living donor; transplant recipient; transplantation; uterus