title: Antiphospholid antibodies and the risk of pregnancy complications.
abstract: Antiphospholipid antibodies (APLAbs) are generally considered as risk factors for foetal death, for premature birth ≤34weeks due to severe pre-eclampsia or severe placental insufficiency and for recurrent consecutive spontaneous abortions <10weeks. Among these three obstetrical morbidities, only the first one is however not regularly questioned. The coexistence of an inflammatory disease and/or of thrombotic manifestations increases the obstetrical risks. Among the three criteria APLAbs, i.e. lupus anticoagulant (LA), anticardiolipin (aCL) Abs, anti-β2 glycoprotein-I (aβ2GP1)Abs, LA seems the more widely associated to clinical risks, the clinical impact of aβ2GP1Abs is progressively defined and the pejorative impact of triple positivity is still discussed. High quality prospective multicentric epidemiological studies are still awaited. The identification of predictors of pregnancy outcome is necessary to streamline the design and use of new treatments acting on pathophysiological molecular targets.
authors.affiliation: Department of Haematology, University Hospital, Nîmes, Nîmes, France; Research Group UPRES EA 2992, University of Montpellier, Montpellier, France; Faculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, France. Electronic address: jean.christophe.gris@chu-nimes.fr.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Gris
authors.affiliation: Department of Haematology, University Hospital, Nîmes, Nîmes, France; Research Group UPRES EA 2992, University of Montpellier, Montpellier, France; Faculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bouvier
authors.affiliation: Department of Haematology, University Hospital, Nîmes, Nîmes, France; Research Group UPRES EA 2992, University of Montpellier, Montpellier, France; Faculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, France.
authors.forename: Eva
authors.initials: E
authors.lastname: Nouvellon
authors.affiliation: Department of Haematology, University Hospital, Nîmes, Nîmes, France; Research Group UPRES EA 2992, University of Montpellier, Montpellier, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Lissalde-Lavigne
authors.affiliation: Department of Haematology, University Hospital, Nîmes, Nîmes, France; Research Group UPRES EA 2992, University of Montpellier, Montpellier, France; Faculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, France.
authors.forename: Erick
authors.initials: E
authors.lastname: Mercier
authors.affiliation: Department of Internal Medicine, University Hospital, Nîmes, Nîmes, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Balducchi
authors.affiliation: Department of Gynaecology and Obstetrics, Nîmes, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Marès
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology / Q000276:immunology; D017153:Antibodies, Anticardiolipin / Q000276:immunology; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000276:immunology; D011225:Pre-Eclampsia / Q000209:etiology* / Q000276:immunology; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000209:etiology / Q000276:immunology; D011446:Prospective Studies; D053482:beta 2-Glycoprotein I / Q000276:immunology
chemical_list: D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D016682:Lupus Coagulation Inhibitor; D053482:beta 2-Glycoprotein I
keywords: Antiphospholipid antibody; Foetal death; Placenta; Pre-eclampsia; Pregnancy