title: Association between periodontal disease and polycystic ovary syndrome: a systematic review.
abstract: The purpose of the present study was to review systematically the association between periodontal diseases (PDs) and polycystic ovary syndrome (PCOS). To address the focused question, 'Is there a relationship between PD and PCOS?' indexed databases were searched up to October 2016 without time or language restrictions using different combinations of the following key words: PCOS, ovarian cysts, PD, periodontitis, gingival diseases and gingivitis. Letters to the Editor, commentaries, historic reviews, case-report, unpublished articles and animal/experimental studies were excluded. Seven case-control studies were included. The number of study participants ranged between 52 and 196 females aged between 15 and 45 years. In three and three studies, proinflammatory cytokines were assessed in gingival crevicular fluid and saliva samples, respectively. In one study, salivary microbes were investigated. All studies reported that a positive association exists between PD and PCOS. In conclusion, there is a positive association between PD and PCOS; however, further well-designed longitudinal controlled clinical trials are needed in this regard. It is recommended that physicians should refer patients with PCOS to oral health-care providers for comprehensive oral evaluation and treatment.
authors.affiliation: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.|Department of General Dentistry, Faculty of Dentistry, Universidad Santa Maria, Caracas, Venezuela.
authors.forename: S V
authors.initials: SV
authors.lastname: Kellesarian
authors.affiliation: Department of General Dentistry, Faculty of Dentistry, Universidad Santa Maria, Caracas, Venezuela.
authors.forename: V R
authors.initials: VR
authors.lastname: Malignaggi
authors.affiliation: Department of Health Services Administration, College of Nursing and Health Sciences, Barry University, Miami, FL, USA.
authors.forename: T V
authors.initials: TV
authors.lastname: Kellesarian
authors.affiliation: Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
authors.forename: A A
authors.initials: AA
authors.lastname: Al-Kheraif
authors.affiliation: Dental Department, King Abdulaziz University Hospital, King Saud University, Riyadh, Saudi Arabia.
authors.forename: M M
authors.initials: MM
authors.lastname: Alwageet
authors.affiliation: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
authors.forename: H
authors.initials: H
authors.lastname: Malmstrom
authors.affiliation: Department of Oral Surgery and Implant Dentistry, Dental School, Johann Wolfgang Goethe, University of Frankfurt, Frankfurt, Germany.|Department of Periodontology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Romanos
authors.affiliation: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
authors.forename: F
authors.initials: F
authors.lastname: Javed
mesh_terms: D005260:Female; D006801:Humans; D010510:Periodontal Diseases / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000276:immunology / Q000382:microbiology