title: Aquaporins in the Skin.
abstract: The skin is the largest organ of the body, serving as an important barrier between the internal milieu and the external environment. The skin is also one of the first lines of defense against microbial infection and other hazards, and thus, the skin has important immune functions . This organ is composed of many cell types, including immune-active dendritic cells (epidermal Langerhans cells and dermal dendritic cells), connective tissue-generating dermal fibroblasts and pigment-producing melanocytes. Comprising the outer skin layer are the epidermal keratinocytes, the predominant cell of this layer, the epidermis , which provides both a mechanical barrier and a water -permeability barrier. Recent data suggest that aquaporins, a family of barrel-shaped proteins surrounding internal pores that allow the passage of water and, in some family members, small solutes such as glycerol , play critical roles in regulating various skin parameters. The involvement of different aquaporin family members in skin function is discussed.
authors.affiliation: Department of Physiology, Medical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.|Department of Medicine (Dermatology), Medical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.
authors.forename: Ravi
authors.initials: R
authors.lastname: Patel
authors.affiliation: Department of Physiology, Medical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.|Department of Medicine (Dermatology), Medical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.
authors.forename: L
authors.initials: L
authors.lastname: Kevin Heard
authors.affiliation: Department of Physiology, Medical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.|Department of Medicine (Dermatology), Medical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.|Charlie Norwood VA Medical Center, One Freedom Way, Augusta, GA, 30904, USA.
authors.forename: Xunsheng
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Physiology, Medical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA. wbollag@augusta.edu.|Department of Medicine (Dermatology), Medical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA. wbollag@augusta.edu.|Charlie Norwood VA Medical Center, One Freedom Way, Augusta, GA, 30904, USA. wbollag@augusta.edu.
authors.forename: Wendy B
authors.initials: WB
authors.lastname: Bollag
mesh_terms: D000818:Animals; D051398:Aquaporin 1 / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D003877:Dermatitis, Contact / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D005786:Gene Expression Regulation; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism*; D007801:Langerhans Cells / Q000166:cytology / Q000378:metabolism; D008544:Melanocytes / Q000166:cytology / Q000378:metabolism; D010539:Permeability; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D011565:Psoriasis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012867:Skin / Q000166:cytology / Q000378:metabolism*; D014867:Water / Q000378:metabolism*
chemical_list: C496020:AQP1 protein, human; D020033:Protein Isoforms; D014867:Water; D051398:Aquaporin 1; D005990:Glycerol
keywords: Aquaporin; Contact hypersensitivity; Epidermis; Glycerol; Psoriasis; Skin; Skin cancer