title: Impact of pre-admission depression on mortality following myocardial infarction.
abstract: BackgroundThe prognostic impact of previous depression on myocardial infarction survival remains poorly understood.AimsTo examine the association between depression and all-cause mortality following myocardial infarction.MethodUsing Danish medical registries, we conducted a nationwide population-based cohort study. We included all patients with first-time myocardial infarction (1995-2014) and identified previous depression as either a depression diagnosis or use of antidepressants. We used Cox regression to compute adjusted mortality rate ratios (aMRRs) with 95% confidence intervals.ResultsWe identified 170 771 patients with first-time myocardial infarction. Patients with myocardial infarction and a previous depression diagnosis had higher 19-year mortality risks (87%v.78%). The overall aMRR was 1.11 (95% CI 1.07-1.15) increasing to 1.22 (95% CI 1.17-1.27) when including use of antidepressants in the depression definition.ConclusionsA history of depression was associated with a moderately increased all-cause mortality following myocardial infarction.
authors.affiliation: Jens Sundbøll, MD, Morten Schmidt, MD, PhD, Kasper Adelborg, MD, Department of Clinical Epidemiology and Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Lars Pedersen, PhD, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Hans Erik Bøtker, MD, PhD, DMSci, Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark; Poul Videbech, MD, DMSci, Psychiatric Centre Glostrup, Glostrup, Denmark; Henrik Toft Sørensen, MD, PhD, DMSci, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark jens.sundboll@clin.au.dk.
authors.forename: Jens
authors.initials: J
authors.lastname: Sundbøll
authors.affiliation: Jens Sundbøll, MD, Morten Schmidt, MD, PhD, Kasper Adelborg, MD, Department of Clinical Epidemiology and Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Lars Pedersen, PhD, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Hans Erik Bøtker, MD, PhD, DMSci, Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark; Poul Videbech, MD, DMSci, Psychiatric Centre Glostrup, Glostrup, Denmark; Henrik Toft Sørensen, MD, PhD, DMSci, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Morten
authors.initials: M
authors.lastname: Schmidt
authors.affiliation: Jens Sundbøll, MD, Morten Schmidt, MD, PhD, Kasper Adelborg, MD, Department of Clinical Epidemiology and Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Lars Pedersen, PhD, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Hans Erik Bøtker, MD, PhD, DMSci, Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark; Poul Videbech, MD, DMSci, Psychiatric Centre Glostrup, Glostrup, Denmark; Henrik Toft Sørensen, MD, PhD, DMSci, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Kasper
authors.initials: K
authors.lastname: Adelborg
authors.affiliation: Jens Sundbøll, MD, Morten Schmidt, MD, PhD, Kasper Adelborg, MD, Department of Clinical Epidemiology and Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Lars Pedersen, PhD, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Hans Erik Bøtker, MD, PhD, DMSci, Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark; Poul Videbech, MD, DMSci, Psychiatric Centre Glostrup, Glostrup, Denmark; Henrik Toft Sørensen, MD, PhD, DMSci, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Lars
authors.initials: L
authors.lastname: Pedersen
authors.affiliation: Jens Sundbøll, MD, Morten Schmidt, MD, PhD, Kasper Adelborg, MD, Department of Clinical Epidemiology and Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Lars Pedersen, PhD, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Hans Erik Bøtker, MD, PhD, DMSci, Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark; Poul Videbech, MD, DMSci, Psychiatric Centre Glostrup, Glostrup, Denmark; Henrik Toft Sørensen, MD, PhD, DMSci, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Hans Erik
authors.initials: HE
authors.lastname: Bøtker
authors.affiliation: Jens Sundbøll, MD, Morten Schmidt, MD, PhD, Kasper Adelborg, MD, Department of Clinical Epidemiology and Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Lars Pedersen, PhD, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Hans Erik Bøtker, MD, PhD, DMSci, Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark; Poul Videbech, MD, DMSci, Psychiatric Centre Glostrup, Glostrup, Denmark; Henrik Toft Sørensen, MD, PhD, DMSci, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Poul
authors.initials: P
authors.lastname: Videbech
authors.affiliation: Jens Sundbøll, MD, Morten Schmidt, MD, PhD, Kasper Adelborg, MD, Department of Clinical Epidemiology and Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Lars Pedersen, PhD, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Hans Erik Bøtker, MD, PhD, DMSci, Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark; Poul Videbech, MD, DMSci, Psychiatric Centre Glostrup, Glostrup, Denmark; Henrik Toft Sørensen, MD, PhD, DMSci, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Henrik Toft
authors.initials: HT
authors.lastname: Sørensen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003718:Denmark / Q000453:epidemiology; D003866:Depressive Disorder / Q000150:complications* / Q000401:mortality; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality* / Q000523:psychology; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors