title: A Review of Suvorexant, Doxepin, Ramelteon, and Tasimelteon for the Treatment of Insomnia in Geriatric Patients.
abstract: Geriatric patients often experience insomnia because of physiological and neurological changes that occur during the aging process. Use of benzodiazepines, nonbenzodiazepine hypnotics, and diphenhydramine for the treatment of insomnia pose an increased risk of cognitive impairment, falls, and fractures in this patient population. Therapeutic alternatives approved by the Food and Drug Administration include suvorexant, doxepin, ramelteon, and tasimelteon, which have shown efficacy and safety in various studies. This paper explores and outlines the available safety and efficacy data associated with these medications and reviews their potential place in therapy in treating insomnia in the geriatric population.
authors.forename: Chelsey
authors.initials: C
authors.lastname: Edmonds
authors.forename: Michael
authors.initials: M
authors.lastname: Swanoski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001381:Azepines / Q000494:pharmacology / Q000627:therapeutic use; D001572:Benzofurans / Q000494:pharmacology / Q000627:therapeutic use; D003521:Cyclopropanes / Q000494:pharmacology / Q000627:therapeutic use; D004316:Doxepin / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D007192:Indenes / Q000494:pharmacology / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D001381:Azepines; D001572:Benzofurans; D003521:Cyclopropanes; D006993:Hypnotics and Sedatives; D007192:Indenes; D014230:Triazoles; C551624:suvorexant; D004316:Doxepin; C495910:ramelteon; C478745:tasimelteon