title: The Contrast Enhancement of Intracranial Arterial Wall on High-resolution MRI and Its Clinical Relevance in Patients with Moyamoya Vasculopathy.
abstract: The purpose of this study is to investigate the characteristics of intracranial vessel wall enhancement and its relationship with ischemic infarction in patients with Moyamoya vasculopathy (MMV). Forty-seven patients with MMV confirmed by angiography were enrolled in this study. The vessel wall enhancement of the distal internal carotid artery, anterior cerebral artery and middle cerebral artery was classified into eccentric and concentric patterns, as well as divided into three grades: grade 0, grade 1 and grade 2. The relationship between ischemic infarction and vessel wall enhancement was also determined. Fifty-six enhanced lesions were found in patients with (n = 25) and without acute infarction (n = 22). The incidence of lesions with grade 2 enhancement in patients with acute infarction was greater than that in those without acute infarction (p = 0.011). In addition, grade 2 enhancement of the intracranial vessel wall was significantly associated with acute ischemic infarction (Odds ratio, 26.7; 95% confidence interval: 2.8-258.2; p = 0.005). Higher-grade enhancement of the intracranial vessel wall is independently associated with acute ischemic infarction in patients with MMV. The characteristics of intracranial vessel wall enhancement may serve as a marker of its stability and provide important insight into ischemic stroke risk factors.
authors.affiliation: Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Maoxue
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Renyuan
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Radiology, Yangzhou First People's Hospital, Yangzhou 225001, China.
authors.forename: Maobin
authors.initials: M
authors.lastname: Guan
authors.affiliation: Center for Biomedical Imaging research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing 100084, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Center for Biomedical Imaging research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing 100084, China.
authors.forename: Le
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Neurology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Center for Biomedical Imaging research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing 100084, China.
authors.forename: Xihai
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000328:Adult; D002545:Brain Ischemia / Q000150:complications / Q000000981:diagnostic imaging; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000473:pathology; D002536:Cerebral Arteries / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D006801:Humans; D020765:Intracranial Arterial Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D011856:Radiographic Image Enhancement / Q000379:methods; D012307:Risk Factors; D020521:Stroke / Q000000981:diagnostic imaging / Q000209:etiology
chemical_list: D003287:Contrast Media