title: Viewing Siglecs through the lens of tumor immunology.
abstract: Many Siglecs function as inhibitory receptors on innate and adaptive immune cells and may contribute to the attenuation of immune responses to tumors. Siglec 9 on neutrophils and Siglec 7 on NK cells are prominent examples of inhibitory Siglecs that can potentially dampen anti-tumor immunity. CD169 is a Siglec that may function as an adhesion molecule and a facilitator of the recognition and internalization of sialic acid decorated apoptotic bodies and exosomes derived from tumors. It can potentially contribute to both the attenuation as well as the facilitation of anti-tumor immunity. Siglecs have been best studied in the tumor context in animal models of cancer. Modulators of Siglec function are likely to be developed and investigated clinically in a cancer context over the next few years.
authors.affiliation: Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USA.
authors.forename: Isabella
authors.initials: I
authors.lastname: Fraschilla
authors.affiliation: Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USA.
authors.forename: Shiv
authors.initials: S
authors.lastname: Pillai
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D056747:Immunomodulation; D007167:Immunotherapy / Q000379:methods*; D007694:Killer Cells, Natural / Q000276:immunology*; D037102:Lectins / Q000276:immunology / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D009504:Neutrophils / Q000276:immunology*; D063267:Sialic Acid Binding Ig-like Lectin 1 / Q000276:immunology / Q000378:metabolism*; D063265:Sialic Acid Binding Immunoglobulin-like Lectins / Q000276:immunology / Q000378:metabolism*; D019139:Tumor Escape
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D037102:Lectins; C571166:SIGLEC1 protein, human; C402206:SIGLEC7 protein, human; C412227:SIGLEC9 protein, human; D063267:Sialic Acid Binding Ig-like Lectin 1; D063265:Sialic Acid Binding Immunoglobulin-like Lectins
keywords: Siglec; cancer/tumor immunology; hypersialylation; immune evasion; immune regulation; inhibitory receptor; sialic acid