title: Voxel-based logistic analysis of PPMI control and Parkinson's disease DaTscans.
abstract: A comprehensive analysis of the Parkinson's Progression Markers Initiative (PPMI) Dopamine Transporter Single Photon Emission Computed Tomography (DaTscan) images is carried out using a voxel-based logistic lasso model. The model reveals that sub-regional voxels in the caudate, the putamen, as well as in the globus pallidus are informative for classifying images into control and PD classes. Further, a new technique called logistic component analysis is developed. This technique reveals that intra-population differences in dopamine transporter concentration and imperfect normalization are significant factors influencing logistic analysis. The interactions with handedness, sex, and age are also evaluated.
authors.affiliation: Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA; Department of Biomedical Engineering, Yale University, New Haven, CT, USA. Electronic address: hemant.tagare@yale.edu.
authors.forename: Hemant D
authors.initials: HD
authors.lastname: Tagare
authors.affiliation: Department of Psychiatry, Stony Brook University, NY, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: DeLorenzo
authors.affiliation: Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
authors.forename: Sudhakar
authors.initials: S
authors.lastname: Chelikani
authors.affiliation: Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Saperstein
authors.affiliation: Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
authors.forename: Robert K
authors.initials: RK
authors.lastname: Fulbright
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping / Q000379:methods*; D002421:Caudate Nucleus / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D005917:Globus Pallidus / Q000000981:diagnostic imaging; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D000069550:Machine Learning; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000145:classification / Q000000981:diagnostic imaging*; D025341:Principal Component Analysis; D011699:Putamen / Q000000981:diagnostic imaging; D012815:Signal Processing, Computer-Assisted; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014326:Tropanes / Q000008:administration & dosage
chemical_list: D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
keywords: DaTscan; Logistic Lasso; Logistic Principal Components; PPMI; Parkinson's disease