title: Advances toward More Efficient Targeted Delivery of Nanoparticles in Vivo: Understanding Interactions between Nanoparticles and Cells.
abstract: In this Perspective, we describe current challenges and recent advances in efficient delivery and targeting of nanoparticles in vivo. We discuss cancer therapy, nanoparticle-biomolecule interactions, nanoparticle trafficking in cells, and triggers and responses to nanoparticle-cell interactions. No matter which functionalization strategy to target cancer is chosen, passive or active targeting, more than 99% of the nanoparticles administered in vivo end up in the mononuclear phagocytic system, mainly sequestered by macrophages. Comprehensive studies, such as the one reported by MacParland et al. in this issue of ACS Nano, will help to close the gap between nanotechnology-based drug-delivery solutions and advanced medicinal products.
authors.affiliation: Centre for BioNano Interactions, School of Chemistry, University College Dublin , Belfield, Dublin 4, Ireland.
authors.forename: Ester
authors.identifier: 0000-0001-8870-5280
authors.initials: E
authors.lastname: Polo
authors.affiliation: Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (CHUS) , Sergas, E15706 Santiago de Compostela, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Collado
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), and Departamento de Física de Partículas, Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors.forename: Beatriz
authors.identifier: 0000-0002-4626-4576
authors.initials: B
authors.lastname: Pelaz
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), and Departamento de Física de Partículas, Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors.forename: Pablo
authors.identifier: 0000-0003-1318-6839
authors.initials: P
authors.lastname: Del Pino
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D036103:Nanotechnology; D009369:Neoplasms / Q000737:chemistry* / Q000188:drug therapy / Q000473:pathology