title: Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases.
abstract: The sigma-1 (σ1) receptor has been associated with regulation of intracellular Ca2+homeostasis, several cellular signaling pathways, and inter-organelle communication, in part through its chaperone activity. In vivo, agonists of the σ1receptor enhance brain plasticity, with particularly well-described impact on learning and memory. Under pathological conditions, σ1receptor agonists can induce cytoprotective responses. These protective responses comprise various complementary pathways that appear to be differentially engaged according to pathological mechanism. Recent studies have highlighted the efficacy of drugs that act through the σ1receptor to mitigate symptoms associated with neurodegenerative disorders with distinct mechanisms of pathogenesis. Here, we will review genetic and pharmacological evidence of σ1receptor engagement in learning and memory disorders, cognitive impairment, and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and Huntington's disease.
authors.affiliation: INSERM U1198, University of Montpellier, Montpellier, 34095, France. tangui.maurice@umontpellier.fr.
authors.forename: Tangui
authors.initials: T
authors.lastname: Maurice
authors.affiliation: INSERM U1198, University of Montpellier, Montpellier, 34095, France.|Institute of Chemical Biology, Ilia State University, Tbilisi, 0162, Georgia.
authors.forename: Nino
authors.initials: N
authors.lastname: Goguadze
mesh_terms: D000818:Animals; D006801:Humans; D008024:Ligands; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy / Q000378:metabolism* / Q000523:psychology; D009410:Nerve Degeneration; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D018697:Nootropic Agents / Q000494:pharmacology; D017480:Receptors, sigma / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D000097605:Sigma-1 Receptor
chemical_list: D008024:Ligands; D018696:Neuroprotective Agents; D018697:Nootropic Agents; D017480:Receptors, sigma; D000097605:Sigma-1 Receptor
keywords: Alzheimer’s disease; Amyotrophic lateral sclerosis; Huntington’s disease; Learning and memory; Multiple sclerosis; Neuroprotection; Parkinson’s disease; σ1 polymorphisms; σ1 receptor