title: Gyrospun antimicrobial nanoparticle loaded fibrous polymeric filters.
abstract: A one step approach to prepare hybrid nanoparticle embedded polymer fibres using pressurised gyration is presented. Two types of novel antimicrobial nanoparticles and poly(methylmethacrylate) polymer were used in this work. X-ray diffraction analysis of the nanoparticles revealed Ag, Cu and W are the main elements present in them. The concentration of the polymer solution and the nanoparticle concentration had a significant influence on the fibre diameter, pore size and morphology. Fibres with a diameter in the range of 6-20μm were spun using 20wt% polymer solutions containing 0.1, 0.25 and 0.5 wt% nanoparticles under 0.3MPa working pressure and a rotational speed of 36,000rpm. Continuous, bead-free fibre morphologies were obtained for each case. The pore size in the fibres varied between 36 and 300nm. Successful incorporation of the nanoparticles in polymer fibres was confirmed by energy dispersive x-ray analysis. The fibres were also gyrospun on to metallic discs to prepare filters which were tested for their antibacterial activity on a suspension of Pseudomonas aeruginosa. Nanoparticle loaded fibres showed higher antibacterial efficacy than pure poly(methylmethacrylate) fibres.
authors.affiliation: Department of Mechanical Engineering, University College London, London WC1E 7JE, UK.
authors.forename: U
authors.initials: U
authors.lastname: Eranka Illangakoon
authors.affiliation: Department of Mechanical Engineering, University College London, London WC1E 7JE, UK.
authors.forename: S
authors.initials: S
authors.lastname: Mahalingam
authors.affiliation: Department of Mechanical Engineering, University College London, London WC1E 7JE, UK.
authors.forename: K
authors.initials: K
authors.lastname: Wang
authors.affiliation: School of Engineering and Technology, University of Hertfordshire, Hatfield AL10 9AB, UK.
authors.forename: Y-K
authors.initials: YK
authors.lastname: Cheong
authors.affiliation: Department of Civil, Environmental and Geomatic Engineering, University College London, London WC1E 7JE, UK.
authors.forename: E
authors.initials: E
authors.lastname: Canales
authors.affiliation: School of Engineering and Technology, University of Hertfordshire, Hatfield AL10 9AB, UK.
authors.forename: G G
authors.initials: GG
authors.lastname: Ren
authors.affiliation: Department of Microbiology, Virology, and Infection Prevention Control, Great Ormond Street Hospital NHS Foundation Trust, London WCIN 3JH, UK.
authors.forename: E
authors.initials: E
authors.lastname: Cloutman-Green
authors.affiliation: Department of Mechanical Engineering, University College London, London WC1E 7JE, UK. Electronic address: m.edirisinghe@ucl.ac.uk.
authors.forename: M
authors.initials: M
authors.lastname: Edirisinghe
authors.affiliation: Department of Civil, Environmental and Geomatic Engineering, University College London, London WC1E 7JE, UK.
authors.forename: L
authors.initials: L
authors.lastname: Ciric
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D006813:Humidity; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011312:Pressure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013193:Stainless Steel / Q000737:chemistry; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D011108:Polymers; D013193:Stainless Steel
keywords: Antimicrobial; Fibres; Filters; Gyrospun; Nanoparticle