title: Synchronous Occurrence of Chronic Myeloid Leukemia and Mantle Cell Lymphoma.
abstract: Chronic myeloid leukemia (CML) and mantle cell lymphoma (MCL) are hematologic malignancies that originate from different oligopotent progenitor stem cells, namely, common myeloid and lymphoid progenitor cells, respectively. Although blastic transformation of CML can occur in the lymphoid lineage and CML has been related to non-Hodgkin lymphoma on transformation, to our knowledge, de novo and synchronous occurrence of CML and MCL has not been reported. Herein, we report the first case of synchronous CML and MCL in an otherwise healthy 38-year-old man. Potential etiologies and pathological relationships between the two malignancies are explored, including the possibility that the downstream effects of BCR-ABL may link it to an overexpression of cyclin D1, which is inherent to the etiology of MCL.
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Prajwol
authors.identifier: 0000-0002-4057-8822
authors.initials: P
authors.lastname: Pathak
authors.affiliation: Department of Pathology, University of Florida, Gainesville, FL, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pathology, University of Florida, Gainesville, FL, USA.
authors.forename: Brian Allen
authors.initials: BA
authors.lastname: Gray
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: William Stratford
authors.initials: WS
authors.lastname: May
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Merry Jennifer
authors.identifier: 0000-0003-3567-3494
authors.initials: MJ
authors.lastname: Markham