title: The effects of presence of a backside screw hole on biotribological behavior of phospholipid polymer-grafted crosslinked polyethylene.
abstract: One of the important factors in determining the success of joint replacement is the wear performance of polyethylene. Although highly crosslinked polyethylene (CLPE) is presently used, it is still not adequate. We have developed a surface modification technology using poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) in an attempt to improve wear performance. In this study, we evaluated the wear and creep deformation resistances of 3-mm and 6-mm thick PMPC-grafted CLPE disks, set on a metal back-plate, with and without a sham screw hole. The gravimetric wear and volumetric change of the disks were examined using a multidirectional pin-on-disk tester. PMPC grafting decreased the gravimetric wear of CLPE regardless of the presence of a screw hole, and did not affect the volumetric change. The volumetric change in the bearing and backside surfaces of the 3-mm thick disk with a screw hole was much larger than that of those without a screw hole or those of the 6-mm thick disk, which was caused by creep deformation. PMPC grafting on the bearing surface can be a material engineering approach to reduce the wear without changing the creep deformation resistance, and is a promising surface modification technology that can be used to increase the longevity of various artificial joints. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 610-618, 2018.
authors.affiliation: Research Department, KYOCERA Medical Corporation, 3-3-31 Miyahara, Yodogawa-ku, Osaka, 532-0003, Japan.|Division of Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Division of Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.|Sensory and Motor System Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Moro
authors.affiliation: Research Department, KYOCERA Medical Corporation, 3-3-31 Miyahara, Yodogawa-ku, Osaka, 532-0003, Japan.|Division of Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.|Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kyomoto
authors.affiliation: Research Department, KYOCERA Medical Corporation, 3-3-31 Miyahara, Yodogawa-ku, Osaka, 532-0003, Japan.|Division of Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Saiga
authors.affiliation: Sensory and Motor System Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Taketomi
authors.affiliation: Department of Orthopaedic Surgery, Saitama Medical University School of Medicine, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.
authors.forename: Yuho
authors.initials: Y
authors.lastname: Kadono
authors.affiliation: Division of Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takatori
authors.affiliation: Sensory and Motor System Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Sakae
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ishihara
mesh_terms: D019342:Acetic Acid / Q000737:chemistry / Q000494:pharmacology; D001863:Bone Screws; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000494:pharmacology*; D005029:Ethylenediamines / Q000737:chemistry / Q000494:pharmacology; D020342:Finite Element Analysis; D016014:Linear Models; D054327:Lubricants / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D020959:Polyethylene / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000494:pharmacology; D019810:Sodium Azide / Q000737:chemistry / Q000494:pharmacology; D013499:Surface Properties; D014466:Ultraviolet Rays
chemical_list: D003432:Cross-Linking Reagents; D005029:Ethylenediamines; D054327:Lubricants; D011109:Polymethacrylic Acids; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine; D012710:Serum Albumin, Bovine; D020959:Polyethylene; D019810:Sodium Azide; D019342:Acetic Acid
keywords: arthroplasty; creep; joint replacement; polyethylene; wear