title: Current knowledge of metabolomic approach in infectious fish disease studies.
abstract: The approaches of transcriptomic and proteomic have been widely used to study host-pathogen interactions in fish diseases, and this is comparable to the recently emerging application of metabolomic in elucidating disease-resistant mechanisms in fish that gives new insight into potential therapeutic strategies to improve fish health. Metabolomic is defined as the large-scale study of all metabolites within an organism and represents the frontline in the 'omics' approaches, providing direct information on the metabolic responses and perturbations in metabolic pathways. In this review, the current research in infectious fish diseases using metabolomic approach will be summarized. The metabolomic approach in economically important fish infected with viruses, bacteria and nematodes will also be discussed. The potential of the metabolomic approach for management of these infectious diseases as well as the challenges and the limitations of metabolomic in fish disease studies will be explored. Current review highlights the impacts of metabolomic studies in infectious fish diseases, which proposed the potential of new therapeutic strategies to enhance disease resistance in fish.
authors.affiliation: Institute of Systems Biology, Universiti Kebangsaan Malaysia, Selangor, Malaysia.
authors.forename: C-F
authors.identifier: http://orcid.org/0000-0002-7601-1385
authors.initials: CF
authors.lastname: Low
authors.affiliation: Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Terengganu, Malaysia.
authors.forename: M Z H
authors.initials: MZH
authors.lastname: Rozaini
authors.affiliation: School of Fisheries and Aquaculture Sciences, Universiti Malaysia Terengganu, Terengganu, Malaysia.
authors.forename: N
authors.initials: N
authors.lastname: Musa
authors.affiliation: Institute of Systems Biology, Universiti Kebangsaan Malaysia, Selangor, Malaysia.
authors.forename: B
authors.initials: B
authors.lastname: Syarul Nataqain
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D018407:Bacterial Physiological Phenomena; D005393:Fish Diseases / Q000378:metabolism* / Q000382:microbiology / Q000469:parasitology / Q000517:prevention & control*; D005399:Fishes; D006790:Host-Parasite Interactions; D054884:Host-Pathogen Interactions; D055432:Metabolomics / Q000295:instrumentation / Q000379:methods*; D009348:Nematoda / Q000502:physiology; D009349:Nematode Infections / Q000378:metabolism / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D014777:Virus Diseases / Q000378:metabolism / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D018406:Virus Physiological Phenomena
keywords: infectious fish diseases; metabolomic; systems biology