title: Neutrophil-to-lymphocyte ratio is elevated in recurringnonmuscle invasive bladder cancer.
abstract: Although it has been shown that the neutrophil-to-lymphocyte ratio (NLR) may predict the progression of nonmuscle invasive bladder cancer (NMIBC), its association with the recurrence of NMIBC has been poorly studied. The aim of this study is to evaluate the association between NLR and disease recurrence in patients with NMIBC.
  
  
  
  The medical records of 428 consecutive initially diagnosed NMIBC patients who underwent transurethral resection between January 2010 and July 2014 were retrospectively reviewed. Patients without a preoperative NLR (n = 6), without a minimum of 6 months of follow-up (n = 56), who were lost to follow-up (n = 38), or who had progressive disease during follow-up (n = 42) were excluded. The demographics, tumor characteristics, and NLRs of patients with and without tumor recurrence were compared.
  
  
  
  Of 286 patients who met the inclusion criteria, 68 (17.43%) had recurrent disease. Tumor size (P = 0.198), tumor type (P = 0.929), and the presence of carcinoma in situ (P = 0.373) were also similar between groups. Patients with recurrent disease had a higher mean NLR (2.62 ± 0.99 vs. 2.2 ± 0.96, P = 0.002).
  
  
  
  Our results show that NLR may be used as a predictor of recurrence in patients with NMIBC; however, prospective studies are required to validate these findings.
authors.affiliation: Department of Urology, Bağcılar Training & Research Hospital, İstanbul, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Yürük
authors.affiliation: Department of Urology, Oregon Health & Science University, Portland, OR, USA.
authors.forename: Theodore Robert
authors.initials: TR
authors.lastname: Saitz
authors.affiliation: Department of Urology, Bağcılar Training & Research Hospital, İstanbul, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Gönültaş
authors.affiliation: Department of Urology, Bağcılar Training & Research Hospital, İstanbul, Turkey.
authors.forename: Ege Can
authors.initials: EC
authors.lastname: Şerefoğlu
authors.affiliation: Department of Urology, Bağcılar Training & Research Hospital, İstanbul, Turkey.
authors.forename: Ahmet Yaser
authors.initials: AY
authors.lastname: Müslümanoğlu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D018655:Lymphocyte Count / Q000706:statistics & numerical data*; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009504:Neutrophils / Q000166:cytology*; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology*; D055815:Young Adult