title: The accumulation of lipids and proteins during red blood cell storage: the roles of leucoreduction and experimental filtration.
abstract: Pre-storage leucoreduction has been universally adopted in most developed countries in Asia, Europe and the Americas. It decreases febrile transfusion reactions, alloimmunisation to HLA antigens, cytomegalovirus exposure, the accumulation of a number of pro-inflammatory mediators in the supernatant, including the accumulation of platelet-and leucocyte-derived proteins and metabolites during routine storage. This review will highlight the lipids and proteins, biological response modifiers (BRMs) that accumulate, their clinical effects in transfused hosts, and methods of mitigation.
authors.affiliation: Bonfils Blood Center, Denver, CO, United States of America.|Department of Pediatrics, School of Medicine, University of Colorado Denver, Aurora, CO, United States of America.|Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, CO, United States of America.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Silliman
authors.affiliation: Bonfils Blood Center, Denver, CO, United States of America.|Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, CO, United States of America.
authors.forename: Timothy
authors.initials: T
authors.lastname: Burke
authors.affiliation: Bonfils Blood Center, Denver, CO, United States of America.|Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, CO, United States of America.
authors.forename: Marguerite R
authors.initials: MR
authors.lastname: Kelher
mesh_terms: D055371:Acute Lung Injury / Q000097:blood / Q000209:etiology / Q000628:therapy; D001793:Blood Preservation / Q000009:adverse effects* / Q000379:methods; D001798:Blood Proteins / Q000378:metabolism*; D017707:Erythrocyte Transfusion / Q000009:adverse effects* / Q000379:methods; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D047589:Leukocyte Reduction Procedures; D050356:Lipid Metabolism
chemical_list: D001798:Blood Proteins