title: A case of coexistence of TSH/GH-secreting pituitary tumor and papillary thyroid carcinoma: Challenges in pathogenesis and management.
abstract: Co-existence of thyrotropin/growth hormone-secreting pituitary adenoma with differentiated thyroid carcinoma is exceedingly rare, with less than 15 cases having been reported. Its clinical presentation and treatment strategy are challenging. We report a case of pituitary macroadenoma, with clinical syndromes of acromegaly and hyperthyroidism, and a thyroid nodule, with cytologically confirmed to be a papillary thyroid carcinoma. Clinical implications, focusing on the strategy for proper management, and possible pathogenesis were discussed.
authors.affiliation: Department of Medicine, Charoenkrung pracharak Hospital, Medical Service Department, Bangkok Metropolitan Administration, Bangkok, Thailand.
authors.forename: Phatharaporn
authors.initials: P
authors.lastname: Kiatpanabhikul
authors.affiliation: Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Shanop
authors.initials: S
authors.lastname: Shuangshoti
authors.affiliation: Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Kraisri
authors.initials: K
authors.lastname: Chantra
authors.affiliation: Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Patpong
authors.initials: P
authors.lastname: Navicharern
authors.affiliation: Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Kanaungnit
authors.initials: K
authors.lastname: Kingpetch
authors.affiliation: Excellence Center for Diabetes, Hormone, and Metabolism, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
authors.forename: Natnicha
authors.initials: N
authors.lastname: Houngngam
authors.affiliation: Excellence Center for Diabetes, Hormone, and Metabolism, King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address: Thiti.S@chula.ac.th.
authors.forename: Thiti
authors.initials: T
authors.lastname: Snabboon
mesh_terms: D002291:Carcinoma, Papillary / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D005260:Female; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D013972:Thyrotropin / Q000097:blood
chemical_list: D013972:Thyrotropin
keywords: Acromegaly; Inappropriate TSH secretion; Pituitary tumor; TSHoma; Thyroid carcinoma