title: Cardio-oncology Related to Heart Failure: Epidermal Growth Factor Receptor Target-Based Therapy.
abstract: Cancer therapy targeting the epidermal growth factor receptor (EGFR)/erythroblastic leukemia viral oncogene B (ErbB)/human EGFR receptor (HER) family of tyrosine kinases has been successfully used in treatment of several malignancies. The ErbB pathways play a role in the maintenance of cardiac homeostasis. This article summarizes current knowledge about EGFR/ErbB/HER receptor-targeted cancer therapeutics focusing on their cardiotoxicity profiles, molecular mechanisms, and implications in clinical cardio-oncology. The article discusses challenges in predicting, monitoring, and treating cardiac dysfunction and heart failure associated with ErbB-targeted cancer therapeutics and highlights opportunities for researchers and clinical investigators.
authors.affiliation: MedStar Washington Hospital Center, MedStar Heart and Vascular Institute, Washington, DC, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Kenigsberg
authors.affiliation: MedStar Washington Hospital Center, MedStar Heart and Vascular Institute, Washington, DC, USA.
authors.forename: Varun
authors.initials: V
authors.lastname: Jain
authors.affiliation: MedStar Washington Hospital Center, MedStar Heart and Vascular Institute, Washington, DC, USA. Electronic address: ana.barac@medstar.net.
authors.forename: Ana
authors.initials: A
authors.lastname: Barac
mesh_terms: D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D006333:Heart Failure / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D047428:Protein Kinase Inhibitors; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: Cancer; Cardiac therapies; Cardiovascular toxicity; EGFR signaling; HER2 pathways; Heart failure; Targeted cancer therapeutics