title: Retraction.
abstract: Retraction: "Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex" by Keleshian VL, Modi HR, Rapoport SI, Rao JS. The above article from Journal of Neurochemistry, published online on 17 February 2013 in Wiley Online Library (wileyonlinelibrary.com) and in volume 121, issue 1, pp. 63-73, has been retracted by agreement between the corresponding author Stanley Rapoport, the Journal's Editor-in-Chief, Jörg Schulz, and John Wiley & Sons Ltd. The Editorial Office was contacted by the author Stanley Rapoport with the request to retract this and a related publication (see below), informing the Editor-in-Chief that the National Institutes of Health (NIH) had found Dr. Jagadeesh S. Rao guilty of research misconduct by falsifying data in the referenced paper. The Editorial Office was forwarded a letter, signed by investigation committee members on behalf of NIH and NIA, which states: "[…] The National Institutes of Health (NIH) investigated allegations of research misconduct involving the falsification of data in "Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex." Keleshian VL, Modi HR, Rapoport SI, Rao JS. Journal of Neurochemistry 2013 Apr; 125(1): 63-73. Based on the unanimous decision of a five member committee, composed of NIH investigators, NIH found that Dr. Jagadeesh Rao, corresponding author, knowingly and intentionally committed research misconduct by falsifying data in Figures 1A, 1G, 3G, and 4D in the manuscript(s) listed above. Dr. Rao was solely responsible for the falsification and all other authors were uninvolved. The report was submitted to the HHS Office of Research Integrity for its review. Because Dr. Rao was the corresponding author, Dr. Stanley I. Rapoport, Senior Advisor for the former Laboratory of Brain Physiology and Metabolism Section, is acting for Dr. Rao, who was his representative, and approves this request to retract this publication using the recommended language, in italics above." A related paper has also been retracted: Rao JS, Ertley RN, Rapoport SI, Bazinet RP, Lee HJ. (2007) Chronic NMDA administration to rats up-regulates frontal cortex cytosolic phospholipase A2and its transcription factor, activator protein-2. J. Neurochem. 102: 1918-1927. References Keleshian V. L., Modi H. R., Rapoport S. I. and Rao J. S. (2013) Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex. J. Neurochem. 125, 63-73. Rao J. S., Ertley R. N., Rapoport S. I., Bazinet R. P. and Lee H. J. (2007) Chronic NMDA administration to rats up-regulates frontal cortex cytosolic phospholipase A2and its transcription factor, activator protein-2. J. Neurochem. 102, 1918-1927.