title: pH-Responsive Peptide Supramolecular Hydrogels with Antibacterial Activity.
abstract: Smart hydrogels have received increasing attention for many applications. Here, we synthesized a class of cationic peptide amphiphiles that can self-assemble into hydrogels by ring-opening polymerization (ROP) and post-modification strategy. The incorporation of cationic lysine residues suppresses the formation of fibril-like structure and further the gelation ability of the samples. Sodium alginate (SA) is used to enhance the rheology performance of the hydrogels. The hydrogels exhibit pH-dependent self-assembly and the gelation behavior that enables them to be ideal smart hydrogel systems for biomedical applications. Furthermore, the as-prepared hybrid peptide hydrogels show antibacterial activity.
authors.affiliation: School of Polymer Science and Engineering, Qingdao University of Science and Technology , Qingdao, 266042, China.|Institute of Chemistry, Chinese Academy of Science , Beijing, 100190, China.
authors.forename: Yaoming
authors.initials: Y
authors.lastname: Wan
authors.affiliation: Institute of Chemistry, Chinese Academy of Science , Beijing, 100190, China.
authors.forename: Libing
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Polymer Science and Engineering, Qingdao University of Science and Technology , Qingdao, 266042, China.
authors.forename: Shuaishuai
authors.initials: S
authors.lastname: Yuan
authors.affiliation: School of Polymer Science and Engineering, Qingdao University of Science and Technology , Qingdao, 266042, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: School of Polymer Science and Engineering, Qingdao University of Science and Technology , Qingdao, 266042, China.|Institute of Chemistry, Chinese Academy of Science , Beijing, 100190, China.
authors.forename: Zhibo
authors.identifier: 0000-0001-9512-1507
authors.initials: Z
authors.lastname: Li
mesh_terms: D000464:Alginates / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D046911:Macromolecular Substances / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D006603:Hexuronic Acids; D020100:Hydrogels; D046911:Macromolecular Substances; D010455:Peptides; D020723:Glucuronic Acid