title: Combination of preoperative CEA and CA19-9 improves prediction outcomes in patients with resectable pancreatic adenocarcinoma: results from a large follow-up cohort.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with a 5-year survival rate of <7%. Carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) are often used to predict the outcome of the malignancy independently. However, the joint prognostic effect of the two tumor biomarkers has not been well determined. The study assessed the joint role of preoperative CA19-9 and CEA in the prognostic prediction of resectable PDAC in a large cohort of patients. The study enrolled 460 eligible patients who were ready to undergo surgery for PDAC. Restricted cubic spline and direct-adjusted survival curve revealed the nonlinear association between the biomarker levels and prognosis of patients. Combination of preoperative CA19-9 and CEA effectively improved the prognostic prediction. About 100 U/mL of CA19-9 and 10 μg/mL of CEA were revealed as potential assistant index for prognostic prediction in patients with resectable PDAC and may be used as one of the criteria to assess the resectability of PDAC.
authors.affiliation: Shanghai Institute of Medical Imaging; Department of Interventional Radiology, Zhongshan Hospital.
authors.forename: Guofeng
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Shanghai Institute of Medical Imaging; Department of Interventional Radiology, Zhongshan Hospital; Department of Epidemiology, School of Public Health; Key Laboratory of Public Health Safety, Ministry of Education.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Pancreatic Surgery, Institute of Pancreatic Disease, Huashan Hospital.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Dayong
authors.initials: D
authors.lastname: Jin
authors.affiliation: Shanghai Institute of Medical Imaging; Department of Interventional Radiology, Zhongshan Hospital.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Shanghai Institute of Medical Imaging; Department of Interventional Radiology, Zhongshan Hospital.
authors.forename: Guoping
authors.initials: G
authors.lastname: Li
authors.affiliation: Shanghai Institute of Medical Imaging; Department of Interventional Radiology, Zhongshan Hospital.
authors.forename: Changyu
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Pancreatic Surgery, Institute of Pancreatic Disease, Huashan Hospital.
authors.forename: Deliang
authors.initials: D
authors.lastname: Fu
authors.affiliation: Department of Epidemiology, School of Public Health; Key Laboratory of Public Health Safety, Ministry of Education.
authors.forename: Wanghong
authors.initials: W
authors.lastname: Xu
authors.affiliation: Shanghai Institute of Medical Imaging; Department of Interventional Radiology, Zhongshan Hospital.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Wang
keywords: CA19-9; CEA; pancreatic cancer; prognosis; tumor biomarkers