title: Block Copolymer Stereoregularity and Its Impact on Polymeric Micellar Nanodrug Delivery.
abstract: Stereoregularity of polymers is known to influence their physicochemical and functional properties in the bulk form. Recent studies have also provided evidence for the effect of polymer stereoregularity on the physicochemical and functional properties of their self-assembled nanostructures. Research in this area has witnessed a relatively rapid pace in the past few years; however, to the best of our knowledge, a proper review of the literature has not been made to date. The goal of this review article was to fill this gap and provide a detailed overview on the current knowledge and understanding on the effect of block copolymer stereoregularity on the properties of their self-assembled nanocarriers such as size, morphology, thermodynamic and kinetic stability, and drug loading and release. Emphasis is placed on poly(ester) containing block copolymers because of their safe history of human use and extensive application in drug delivery research.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta , Edmonton, Alberta T6G 2E1, Canada.
authors.forename: Hoda
authors.initials: H
authors.lastname: Soleymani Abyaneh
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta , Edmonton, Alberta T6G 2E1, Canada.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Vakili
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta , Edmonton, Alberta T6G 2E1, Canada.|School of Pharmacy, Shaheed Beheshti Univ. of Med. Sci. , P.O. Box 14155-6153, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Shafaati
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta , Edmonton, Alberta T6G 2E1, Canada.|Department of Chemical and Materials Engineering, University of Alberta , Edmonton, Alberta T6G 2V4, Canada.
authors.forename: Afsaneh
authors.identifier: 0000-0001-5108-7124
authors.initials: A
authors.lastname: Lavasanifar
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D008823:Micelles; D036103:Nanotechnology / Q000379:methods; D011108:Polymers / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D008823:Micelles; D011108:Polymers
keywords: polymer crystallinity; polymeric micelles; stereoactive polymers; stereocomplex micelles; stereoregularity; tacticity