title: Assessment of Sleep in Patients Receiving Invasive Mechanical Ventilation in a Specialized Weaning Unit.
abstract: A restful sleep is essential for regenerative processes and remains crucial for patients recovering from stressful periods in the intensive care unit. The current study aimed to assess sleep quality in critically ill patients receiving invasive mechanical ventilation within a specialized weaning unit in hospital.
  
  
  
  Tracheotomized subjects undergoing prolonged weaning from mechanical ventilation were included in the study. Polysomnography and gas exchange monitoring was performed during nocturnal ventilation. Subjective evaluation of sleep quality and health-related quality of life were also assessed.
  
  
  
  Nineteen subjects completed the study protocol. Sleep architecture was highly heterogeneous across individual subjects. Mean total sleep time (TST) was 273 ± 114 min, sleep efficacy 70 ± 23%, slow-wave sleep 25.7 ± 18.4%/TST, rapid eye movement sleep 9.6 ± 7.5%/TST, and arousal index 18.7 ± 12.4/h. No significant difference in sleep quality was found between subjects with successful (N = 7) or unsuccessful (N = 12) weaning. Bicarbonate levels were negatively correlated both with sleep efficacy and sleep quality, that latter of which was subjectively assessed by the subjects using a visual analogue scale.
  
  
  
  Subjects who were undergoing prolonged weaning from mechanical ventilation and admitted to a specialized weaning unit, showed reduced sleep quality with preservation of high amounts of slow-wave sleep.
authors.affiliation: Department of Pneumology, Cologne-Merheim Hospital, Kliniken der Stadt Koeln gGmbH, Witten/Herdecke University Hospital, Ostmerheimer Strasse 200, 51109, Cologne, Germany.
authors.forename: Sophie Emilia
authors.initials: SE
authors.lastname: Huttmann
authors.affiliation: Department of Pneumology, Cologne-Merheim Hospital, Kliniken der Stadt Koeln gGmbH, Witten/Herdecke University Hospital, Ostmerheimer Strasse 200, 51109, Cologne, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Wilms
authors.affiliation: Department of Pneumology, Cologne-Merheim Hospital, Kliniken der Stadt Koeln gGmbH, Witten/Herdecke University Hospital, Ostmerheimer Strasse 200, 51109, Cologne, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Hamm
authors.affiliation: Department of Pneumology, Cologne-Merheim Hospital, Kliniken der Stadt Koeln gGmbH, Witten/Herdecke University Hospital, Ostmerheimer Strasse 200, 51109, Cologne, Germany.
authors.forename: Friederike Sophie
authors.initials: FS
authors.lastname: Magnet
authors.affiliation: Department of Pneumology, Cologne-Merheim Hospital, Kliniken der Stadt Koeln gGmbH, Witten/Herdecke University Hospital, Ostmerheimer Strasse 200, 51109, Cologne, Germany.
authors.forename: Wolfram
authors.initials: W
authors.lastname: Windisch
authors.affiliation: Department of Pneumology, Cologne-Merheim Hospital, Kliniken der Stadt Koeln gGmbH, Witten/Herdecke University Hospital, Ostmerheimer Strasse 200, 51109, Cologne, Germany. storrej@kliniken-koeln.de.|Department of Pneumology, University Medical Hospital, Freiburg, Germany. storrej@kliniken-koeln.de.
authors.forename: Jan Hendrik
authors.initials: JH
authors.lastname: Storre
mesh_terms: D000368:Aged; D016638:Critical Illness / Q000628:therapy*; D005260:Female; D006757:Hospital Units; D006801:Humans; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D017286:Polysomnography; D011788:Quality of Life; D012121:Respiration, Artificial; D012890:Sleep; D011795:Surveys and Questionnaires; D013997:Time Factors; D014139:Tracheostomy; D015300:Ventilator Weaning / Q000379:methods*
keywords: Mechanical ventilation; Polysomnography; Sleep quality; Sleep stages; Tracheostomy; Ventilator weaning