title: Correlation between Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Infant Birth Outcomes: A Meta-Analysis and an Experimental Study.
abstract: Only a few epidemiological studies have focused on the correlation between prenatal exposure to polybrominated diphenyl ethers (PBDEs) and infant birth outcomes (IBO), and the results of these epidemiological studies are contradictory. The objective of this study was to assess the correlation between prenatal exposure to PBDEs (PEP) and IBO (i.e., birth weight) in an analysis of epidemiological studies and an experimental animals study. We searched databases of the medical literature (PubMed, Excerpta Medica Database, Cochrane Library, and China National Knowledge Infrastructure) for articles and pooled the results of the included epidemiological studies. In parallel, birth outcomes (i.e., birth weights of pups) were collected from female Sprague-Dawley (SD) rats exposed to decabromodiphenyl ether (DecaBDE) in the diet from five weeks of age to delivery. A significant negative relationship was found between human PBDE burden and birth weight in the analysis of seven epidemiological studies based on a random-effects model (β = -50.598; 95% confidence interval (CI) -95.914, -5.282;I² = 11.8%;p= 0.029). In the experimental animal study, a significant decrease in birth weight in the DecaBDE-treated group was also observed (5.26 ± 0.39 vs. 5.8 ± 0.58,p= 0.0132). The results of our study contribute to increasing evidence suggesting that PEP adversely impacts IBO, especially birth weight.
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China. zhaoxuemincmu@126.com.
authors.forename: Xuemin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China. clearling405@163.com.
authors.forename: Shiqiao
authors.initials: S
authors.lastname: Peng
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China. xiangyang0430@outlook.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiang
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China. 13324086880@163.com.
authors.forename: Yali
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China. jli23@cmu.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China. shanzhongyan@medmail.com.cn.
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Shan
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China. twp@vip.163.com.
authors.forename: Weiping
authors.initials: W
authors.lastname: Teng
mesh_terms: D000818:Animals; D001724:Birth Weight / Q000187:drug effects*; D002681:China / Q000453:epidemiology; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000009:adverse effects*; D006801:Humans; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000453:epidemiology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D055768:Halogenated Diphenyl Ethers; C010902:decabromobiphenyl ether
keywords: birth outcomes; birth weight; head circumference; polybrominated diphenyl ethers