title: An atlas and analysis of bovine skeletal muscle long noncoding RNAs.
abstract: Long noncoding RNAs (lncRNAs) have various biological functions and have been extensively studied in recent years. However, the identification and characterization of bovine lncRNAs in skeletal muscle has been very limited compared with that of lncRNAs in other model organisms. In this study, 7188 bovine skeletal muscle lncRNAs were identified by RNA-Seq and a stringent screening procedure in four different muscle tissues. These lncRNAs shared many characteristics with other mammalian lncRNAs, such as a shorter open reading frame and lower expression level than for mRNAs. Furthermore, the chromosomal locations and global expression patterns for these lncRNAs are also described in detail. More importantly, we detected the important interaction relationships of lncRNAs-miRNAs-mRNAs related to muscle development among 36 lncRNAs, 62 miRNAs and 12 mRNAs. Our results provide a global expression pattern of lncRNAs specific to bovine skeletal muscle and provide important targets for revealing the function of bovine muscle development by thoroughly studying the interaction relationships of lncRNAs-miRNAs-mRNAs.
authors.affiliation: College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300384, China.|The Key Laboratory of Mammalian Reproductive Biology and Biotechnology of the Ministry of Education, Inner Mongolia University, Hohhot, 010071, China.
authors.forename: X F
authors.initials: XF
authors.lastname: Liu
authors.affiliation: College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300384, China.
authors.forename: X B
authors.initials: XB
authors.lastname: Ding
authors.affiliation: College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300384, China.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.affiliation: College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300384, China.
authors.forename: C F
authors.initials: CF
authors.lastname: Jin
authors.affiliation: College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300384, China.
authors.forename: Y W
authors.initials: YW
authors.lastname: Yue
authors.affiliation: The Key Laboratory of Mammalian Reproductive Biology and Biotechnology of the Ministry of Education, Inner Mongolia University, Hohhot, 010071, China.
authors.forename: G P
authors.initials: GP
authors.lastname: Li
authors.affiliation: College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300384, China.
authors.forename: H
authors.initials: H
authors.lastname: Guo
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping; D015870:Gene Expression; D035683:MicroRNAs / Q000235:genetics; D018482:Muscle, Skeletal / Q000254:growth & development / Q000378:metabolism*; D016366:Open Reading Frames; D062085:RNA, Long Noncoding / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D017423:Sequence Analysis, RNA; D059467:Transcriptome
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding; D012333:RNA, Messenger
keywords: RNA-sequencing; interaction relationships; lncRNAs expression; muscle development