title: Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance.
abstract: Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression of ATP-binding cassette transporters is considered one of the major reasons for pharmacoresistance. In this review, we have summarized the regulation of ABC transporters in response to oxidative stress due to disease and antiepileptic drugs. Further, ketogenic diet and antioxidants were examined for their role in pharmacoresistance. The understanding of signalling pathways and mechanism involved may help in identifying potential therapeutic targets and improving drug response.
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) Campus, Delhi 110007, India. gpkgrewal@gmail.com.|Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi 110007, India. gpkgrewal@gmail.com.
authors.forename: Gurpreet Kaur
authors.initials: GK
authors.lastname: Grewal
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) Campus, Delhi 110007, India. samkukal07@gmail.com.|Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi 110007, India. samkukal07@gmail.com.
authors.forename: Samiksha
authors.initials: S
authors.lastname: Kukal
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) Campus, Delhi 110007, India. kanojia29.2008@gmail.com.|Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi 110007, India. kanojia29.2008@gmail.com.
authors.forename: Neha
authors.initials: N
authors.lastname: Kanojia
authors.affiliation: Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy. luciano.saso@uniroma1.it.
authors.forename: Luciano
authors.initials: L
authors.lastname: Saso
authors.affiliation: Nucleic Acids Research Lab, Department of Chemistry, University of Delhi (North Campus), Delhi 110007, India. shrikant.kukreti6@gmail.com.
authors.forename: Shrikant
authors.initials: S
authors.lastname: Kukreti
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) Campus, Delhi 110007, India. ritus@igib.res.in.|Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi 110007, India. ritus@igib.res.in.
authors.forename: Ritushree
authors.initials: R
authors.lastname: Kukreti
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000927:Anticonvulsants / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000378:metabolism; D003131:Combined Modality Therapy; D055423:Diet, Ketogenic / Q000379:methods; D004351:Drug Resistance / Q000187:drug effects; D004827:Epilepsy / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D015398:Signal Transduction
chemical_list: D018528:ATP-Binding Cassette Transporters; D000927:Anticonvulsants; D000975:Antioxidants
keywords: ABC transporters; antiepileptic drugs; epilepsy; oxidative stress; pharmacoresistance