title: Ph-activated nano-amorphous calcium phosphate-based cement to reduce dental enamel demineralization.
abstract: Enamel demineralization is destructive, esthetically compromised, and costly complications for orthodontic patients. Nano-sized amorphous calcium phosphate (NACP) has been explored to address this challenge. The 20% NACP-loaded ortho-cement notably exhibited favorable behavior on reducing demineralization of enamel around brackets in a caries model designed to simulate the carious attack. The 20% NACP-loaded ortho-cement markedly promotes higher calcium and phosphate release at a low pH, and the mineral loss was almost two fold lower and carious lesion depth decreased the by 1/3. This novel approach is promising co-adjuvant route for prevention of dental caries dissemination in millions of patients under orthodontic treatment.
authors.affiliation: a Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry , University of Maryland Dental School , Baltimore , MD , USA.
authors.forename: Mary A S
authors.initials: MAS
authors.lastname: Melo
authors.affiliation: a Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry , University of Maryland Dental School , Baltimore , MD , USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Weir
authors.affiliation: b Division of Operative Dentistry, School of Dentistry , University of Fortaleza, Edson Queiroz Foundation , Fortaleza , Brazil.
authors.forename: Vanara F
authors.initials: VF
authors.lastname: Passos
authors.affiliation: a Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry , University of Maryland Dental School , Baltimore , MD , USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Powers
authors.affiliation: a Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry , University of Maryland Dental School , Baltimore , MD , USA.|c Center for Stem Cell Biology & Regenerative Medicine , University of Maryland School of Medicine , Baltimore , MD , USA.|d Department of Mechanical Engineering , University of Maryland , Baltimore County , MD , USA.
authors.forename: Hockin H K
authors.initials: HHK
authors.lastname: Xu
mesh_terms: D002130:Calcium Phosphates / Q000737:chemistry*; D003738:Dental Cements / Q000737:chemistry* / Q000494:pharmacology*; D003743:Dental Enamel / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008903:Minerals / Q000378:metabolism*; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D002130:Calcium Phosphates; D003738:Dental Cements; D008903:Minerals; C519480:amorphous calcium phosphate
keywords: Dental caries; calcium phosphates; mineral; nanoparticles; resin cements