title: [Statins in periodontitis therapy].
abstract: Statins inhibit the activity of enzyme 3-hydroxy-3-methyl-acetyl coenzyme A reductase and further inhibit cholesterol synthesis. Statins are the most widely used cholesterol-lowering drugs in clinical practice. Studies have found that statins also play a positive role in periodontitis treatment. In this paper, we reviewed the functions of statins in bone metabolism and anti-inflammation in periodontitis. In addition, the application of statins as a local drug delivery system in the treatment of periodontitis was described.
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Techonology, Kunming 650500, China.
authors.forename: S S
authors.initials: SS
authors.lastname: Li
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Techonology, Kunming 650500, China.
authors.forename: Y S
authors.initials: YS
authors.lastname: Guo
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Techonology, Kunming 650500, China.
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Techonology, Kunming 650500, China.
authors.forename: Y G
authors.initials: YG
authors.lastname: Zhao
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Techonology, Kunming 650500, China.
authors.forename: J H
authors.initials: JH
authors.lastname: Dan
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Techonology, Kunming 650500, China.
authors.forename: W R
authors.initials: WR
authors.lastname: Tang
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D010518:Periodontitis / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Drug therapy; Periodontitis; Statins