title: [Effects of strontium ranelate on the expression of BMP-2 in the mid-palatal suture of rats during rapid maxillary expansion].
abstract: OBJECTIVE
  To investigate the effects of strontium ranelate on the expression of BMP-2 during rapid maxillary expansion.
  
  
  METHODS
  Thirty-six male 6-week- old male Wistar rats were selected. They were randomly divided into 3 groups. Group A was designed as a control group. An expanded application producing 100 g force was fixed between the first and the second molar on both sides of the rats in group B and group C. 600 mg/kg strontium ranelate was given to the rats in group C daily via an orogastric route, while the equal normal saline was given to the rats in group B. Then the rats were sacrificed on day 4, 7 and 10. The expression of BMP-2 which is a sign of bone formation was detected with immunohistochemical staining and analyzed with Image-pro plus 5.0. SPSS19.0 software package was used for statistical analysis.
  
  
  RESULTS
  The expression of BMP-2 in the midpalatal suture was significantly greater in group B than that in group A on day 4 (P<0.05); however, there was no significant difference between group A and group B on day 7 and 10 (P>0.05). The expression of BMP-2 in the midpalatal suture in group C was significantly greater than that in the other two groups at each time point (P<0.05).
  
  
  CONCLUSIONS
  Strontium ranelate promotes the expression time and quantity of BMP-2 in the mid-palatal suture of rats during rapid maxillary expansion and may accelerate bone formation during rapid maxillary expansion.
authors.affiliation: Department of Orthodontics,School of Stomatology, Shandong University. Jinan 250012,China. E-mail:1193126470@qq.com.
authors.forename: Chao
authors.initials: C
authors.lastname: Xu
authors.forename: Xu-Xia
authors.initials: XX
authors.lastname: Wang
authors.forename: Ying-Zi
authors.initials: YZ
authors.lastname: Wang
authors.forename: Pan-Pan
authors.initials: PP
authors.lastname: Yang
authors.forename: Shu-Ya
authors.initials: SY
authors.lastname: Zhao
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D055396:Bone Morphogenetic Protein 2 / Q000235:genetics / Q000378:metabolism*; D003393:Cranial Sutures; D008297:Male; D010012:Osteogenesis; D010155:Palatal Expansion Technique; D010159:Palate; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013537:Sutures; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D050071:Bone Density Conservation Agents; D055396:Bone Morphogenetic Protein 2; D013876:Thiophenes; C081587:strontium ranelate