title: Integrated multi-omic analyses in Biomphalaria-Schistosoma dialogue reveal the immunobiological significance of FREP-SmPoMuc interaction.
abstract: The fresh water snail Biomphalaria glabrata is one of the vectors of the trematode pathogen Schistosoma mansoni, which is one of the agents responsible of human schistosomiasis. In this host-parasite interaction, co-evolutionary dynamic results into an infectivity mosaic known as compatibility polymorphism. Integrative approaches including large scale molecular approaches have been conducted in recent years to improve our understanding of the mechanisms underlying compatibility. This review presents the combination of integrated Multi-Omic approaches leading to the discovery of two repertoires of polymorphic and/or diversified interacting molecules: the parasite antigens S. mansoni polymorphic mucins (SmPoMucs) and the B. glabrata immune receptors fibrinogen-related proteins (FREPs). We argue that their interactions may be major components for defining the compatible/incompatible status of a specific snail/schistosome combination.
authors.affiliation: Univ. Perpignan Via Domitia, IHPE UMR 5244, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
authors.forename: Anaïs
authors.initials: A
authors.lastname: Portet
authors.affiliation: Univ. Perpignan Via Domitia, IHPE UMR 5244, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
authors.forename: Silvain
authors.initials: S
authors.lastname: Pinaud
authors.affiliation: Univ. Perpignan Via Domitia, IHPE UMR 5244, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Tetreau
authors.affiliation: Univ. Perpignan Via Domitia, IHPE UMR 5244, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
authors.forename: Richard
authors.initials: R
authors.lastname: Galinier
authors.affiliation: Univ. Perpignan Via Domitia, IHPE UMR 5244, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Cosseau
authors.affiliation: Univ. Perpignan Via Domitia, IHPE UMR 5244, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
authors.forename: David
authors.initials: D
authors.lastname: Duval
authors.affiliation: Univ. Perpignan Via Domitia, IHPE UMR 5244, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
authors.forename: Christoph
authors.initials: C
authors.lastname: Grunau
authors.affiliation: Univ. Perpignan Via Domitia, IHPE UMR 5244, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Mitta
authors.affiliation: Univ. Perpignan Via Domitia, IHPE UMR 5244, IFREMER, Univ. Montpellier, F-66860 Perpignan, France. Electronic address: benjamin.gourbal@univ-perp.fr.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Gourbal
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000235:genetics* / Q000378:metabolism; D005075:Biological Evolution; D001700:Biomphalaria / Q000276:immunology* / Q000469:parasitology; D004199:Disease Vectors; D006790:Host-Parasite Interactions; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics* / Q000378:metabolism; D009077:Mucins / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D040901:Proteomics; D012550:Schistosoma mansoni / Q000276:immunology*; D012552:Schistosomiasis / Q000276:immunology*; D059467:Transcriptome
chemical_list: D000947:Antigens, Helminth; D007136:Immunoglobulins; D009077:Mucins
keywords: Biomphalaria glabrata; Compatibility polymorphism; FREPs; Schistosoma mansoni; SmPoMucs