title: Immune cell subsets, cytokine and cortisol levels during the first week of life in neonates born to pre-eclamptic mothers.
abstract: To address the hypothesis that pre-eclampsia (PE) impacts the fetal immune system, we investigated the prevalence of distinct immune cell subsets along with plasma cortisol and cytokine levels in pre-term newborns of PE mothers.
  
  
  
  Cord blood and peripheral blood samples on the 1st, 3rd and 7th postnatal days of life were collected from 14 pre-term infants affected by PE and 14 non-PE pregnancies. We measured plasma cortisol and cytokine levels with immunoassays and assessed the prevalence of T, NK and DC subsets using flow cytometry.
  
  
  
  The prevalence of CD4+ cells was lower in PE infants, while that of memory T cells was higher. Myeloid DCs had a lower prevalence in PE neonates. Cytokine and cortisol levels were lower in PE neonates.
  
  
  
  Our observations show that PE pregnancies are associated with altered newborn immune status during the first week of life.
authors.affiliation: First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
authors.forename: Florentina
authors.initials: F
authors.lastname: Sava
authors.affiliation: First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
authors.forename: Gergely
authors.identifier: 0000-0003-0178-1243
authors.initials: G
authors.lastname: Toldi
authors.affiliation: First Department of Pediatrics, Semmelweis University, Budapest, Hungary.
authors.forename: András
authors.initials: A
authors.lastname: Treszl
authors.affiliation: First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
authors.forename: Júlia
authors.initials: J
authors.lastname: Hajdú
authors.affiliation: First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Harmath
authors.affiliation: First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Rigó
authors.affiliation: First Department of Pediatrics, Semmelweis University, Budapest, Hungary.|MTA-SE Research Group of Pediatrics and Nephrology, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Tivadar
authors.initials: T
authors.lastname: Tulassay
authors.affiliation: MTA-SE Research Group of Pediatrics and Nephrology, Hungarian Academy of Sciences, Budapest, Hungary.|Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Barna
authors.initials: B
authors.lastname: Vásárhelyi
mesh_terms: D016207:Cytokines / Q000097:blood*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007231:Infant, Newborn / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D009035:Mothers; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D016207:Cytokines; D006854:Hydrocortisone
keywords: CD4; HLA-DR; cortisol; memory T cell; pre-eclampsia; pre-term neonate