title: Dual-Targeted Multifunctional Nanoparticles for Magnetic Resonance Imaging Guided Cancer Diagnosis and Therapy.
abstract: Hybrid nanostructures with combined functionalities can be rationally designed to achieve synergistic effects for efficient cancer treatment. Herein, a multifunctional nanoplatform is constructed, containing an inner core of an anticancer drug MTX surrounding by a nanometer-thin layer of gold as the shell with Fe3O4magnetic nanoparticles (NPs) evenly distributed in the gold layer, and the outermost hybrid LA-PEG-MTX molecules as surface coating agent (denoted as MFG-LPM NPs). This nanocomposite possesses very high drug loading capacity as the entire core is MTX and integrates magnetic- and active- targeting drug delivery, light-controlled drug release, magnetic resonance imaging (MRI), as well as photothermal and chemotherapy. With a strong near-infrared (NIR) absorbance at 808 nm, the nanocomposite enables temperature elevation and light-triggered MTX release. In vitro cytotoxicity studies indicate that the strategy of combining therapy leads to a synergistic effect with high cancer cell killing efficacy. In consistency with this, due to the high accumulation of MFG-LPM NPs at tumor site and their combinatorial chemo-photothermal effects, 100% in vivo tumor elimination can be achieved. Additionally, in vivo MRI of tumor-bearing mice demonstrates an impressive performance of MFG-LPM NPs as a T2contrast agent. Therefore, such multifunctional nanocomposite has the potential to serve as an excellent theranostic agent that collectively integrates multiple functions for efficient MRI guided cancer diagnosis and treatment.
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University , Suzhou Jiangsu 215123, P. R. China.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Nan
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University , Suzhou Jiangsu 215123, P. R. China.
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University , Suzhou Jiangsu 215123, P. R. China.
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University , Suzhou Jiangsu 215123, P. R. China.
authors.forename: Mengjiao
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Institute for Bioengineering, School of Engineering, University of Edinburgh , Edinburgh EH9 3JL, United Kingdom.
authors.forename: Xianfeng
authors.identifier: http://orcid.org/0000-0002-3189-2756
authors.initials: X
authors.lastname: Chen
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University , Suzhou Jiangsu 215123, P. R. China.
authors.forename: Xiaohong
authors.identifier: http://orcid.org/0000-0002-6732-2499
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004317:Doxorubicin; D016503:Drug Delivery Systems; D008279:Magnetic Resonance Imaging; D051379:Mice; D053758:Nanoparticles; D000068936:Theranostic Nanomedicine
chemical_list: D004317:Doxorubicin
keywords: chemotherapy; dual-target; magnetic resonance imaging; multifunctional nanocomposite; photothermal