title: Effect of maternal and neonatal interleukin-6 - 174 G/C polymorphism on preterm birth and neonatal morbidity.
abstract: OBJECTIVE
  The aim of this study was to analyze maternal and neonatal interleukin 6 (IL-6) (-174 G/C) polymorphism and to determine effect on preterm birth and neonatal morbidity.
  
  
  METHODS
  One hundred and sixty-four mothers (100 term births, 64 preterm births) and 183 newborn infants who were 100 healthy term and 83 preterm babies followed in newborn intensive care units were evaluated. PCR-RFLP was performed for IL-6 (-174 G/C) genotyping.
  
  
  RESULTS
  The rate of GG genotype in mothers of term and preterm infants were 54% (n = 54/100), 75% (n = 48/64), respectively (p > .05) and the rate of GC + CC genotype was 46% (n = 46/100) and 25% (n = 16/64) in mothers giving term and preterm birth (PTB), respectively (p < .05). Additionally, the rate of GG genotype was 65% (n = 65/100) and 81.9% (n = 68/83) in term infants and preterm infants, respectively. GC + CC genotype was 35% (n = 35/100) in term infants and 18.1% (n = 15/83) in preterm infants (p < .05). The effect of IL-6 (-174) GC + CC genotype on PTB was statistically significant.
  
  
  CONCLUSIONS
  The IL-6 174 G/C gene polymorphism was significantly different between mothers who were giving to term and preterm birth. The presence of polymorphism is protective against preterm birth and was not associated with neonatal outcome.
authors.affiliation: a Department of Pediatrics , Faculty of Medicine, Başkent University , Ankara , Turkey.
authors.forename: N Mutlu
authors.initials: NM
authors.lastname: Karakaş
authors.affiliation: b Department of Neonatology , Faculty of Medicine, Başkent University , Ankara , Turkey.
authors.forename: Ayse N
authors.initials: AN
authors.lastname: Ecevit
authors.affiliation: c Department of Medical Biology , Faculty of Medicine, Başkent University , Ankara , Turkey.
authors.forename: Yaprak
authors.initials: Y
authors.lastname: Yalçın
authors.affiliation: a Department of Pediatrics , Faculty of Medicine, Başkent University , Ankara , Turkey.
authors.forename: Beril
authors.initials: B
authors.lastname: Özdemir
authors.affiliation: c Department of Medical Biology , Faculty of Medicine, Başkent University , Ankara , Turkey.
authors.forename: Hasibe
authors.initials: H
authors.lastname: Verdi
authors.affiliation: d Department of Biostatistic , Faculty of Medicine, Başkent University , Ankara , Turkey.
authors.forename: M Ağah
authors.initials: MA
authors.lastname: Tekindal
authors.affiliation: e Department of Pediatric Hematology.
authors.forename: Namık Y
authors.initials: NY
authors.lastname: Özbek
authors.affiliation: b Department of Neonatology , Faculty of Medicine, Başkent University , Ankara , Turkey.
authors.forename: Aylin
authors.initials: A
authors.lastname: Tarcan
authors.affiliation: c Department of Medical Biology , Faculty of Medicine, Başkent University , Ankara , Turkey.
authors.forename: Fatma B
authors.initials: FB
authors.lastname: Ataç
authors.affiliation: f Department of Obstetrics and Gynecology , Faculty of Medicine, Başkent University , Ankara , Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Haberal
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000235:genetics*; D007234:Infant, Premature; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6
keywords: IL-6 − 174 G/C gene polymorphism; Preterm birth; neonatal morbidity