title: The acute airway inflammation induced by PM2.5exposure and the treatment of essential oils in Balb/c mice.
abstract: PM2.5is the main particulate air pollutant whose aerodynamic diameter is less than 2.5 micron. The inflammation of various respiratory diseases are associated with PM2.5inhalation. Pro-inflammatory cytokine IL-1β generated from effected cells usually plays a crucial role in many kinds of lung inflammatory reactions. The exacerbation of Th immune responses are identified in some PM2.5related diseases. To elucidate the underlying mechanism of PM2.5-induced acute lung inflammation, we exposed Balb/c mice to PM2.5intratracheally and established a mice model. Acute lung inflammation and increased IL-1β expression was observed after PM2.5instillation. Regulatory factors of IL-1β (TLR4/MyD88 signaling pathway and NLRP3 inflammasome) participated in this lung inflammatory response as well. Treatment with compound essential oils (CEOs) substantially attenuated PM2.5-induced acute lung inflammation. The decreased IL-1β and Th immune responses after CEOs treatment were significant. PM2.5may increase the secretion of IL-1β through TLR4/MyD88 and NLRP3 pathway resulting in murine airway inflammation. CEOs could attenuate the lung inflammation by reducing IL-1β and Th immune responses in this model. This study describes a potentially important mechanism of PM2.5-induced acute lung inflammation and that may bring about novel therapies for the inflammatory diseases associated with PM2.5inhalation.
authors.affiliation: Dept of Chemistry, Dalian Medical University, Dalian 116044, Liaoning Province, People's Republic of China.
authors.forename: Hetong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Dept of Immunological and Microbiological Laboratory, Dalian Medical University, Dalian 116044, Liaoning Province, People's Republic of China.
authors.forename: Laiyu
authors.initials: L
authors.lastname: Song
authors.affiliation: Atmospheric Environment Research Institute, China Research Academy of Environmental Sciences, Beijing 100012, People's Republic of China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Ju
authors.affiliation: Environmental Monitoring Station of Langfan, Langfang Environmental Protection Bureau, Langfang 065000, Hebei Province, People's Republic of China.
authors.forename: Xuguang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Dept of Chemistry, Dalian Medical University, Dalian 116044, Liaoning Province, People's Republic of China.
authors.forename: Lu
authors.initials: L
authors.lastname: Dong
authors.affiliation: Dept of Chemistry, Dalian Medical University, Dalian 116044, Liaoning Province, People's Republic of China.
authors.forename: Yining
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Dept of Chemistry, Dalian Medical University, Dalian 116044, Liaoning Province, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Ya
authors.affiliation: Dept of Nuclear Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, LiaoNing Province, People's Republic of China.
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.affiliation: Dept of Chemistry, Dalian Medical University, Dalian 116044, Liaoning Province, People's Republic of China.
authors.forename: Fasheng
authors.initials: F
authors.lastname: Li
mesh_terms: D000208:Acute Disease; D000393:Air Pollutants / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D015870:Gene Expression / Q000187:drug effects / Q000276:immunology; D058847:Inflammasomes / Q000187:drug effects / Q000378:metabolism; D053583:Interleukin-1beta / Q000235:genetics / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008807:Mice, Inbred BALB C; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein / Q000378:metabolism; D009822:Oils, Volatile / Q000494:pharmacology*; D010316:Particle Size; D052638:Particulate Matter / Q000737:chemistry / Q000633:toxicity*; D011014:Pneumonia / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
chemical_list: D000393:Air Pollutants; D058847:Inflammasomes; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C492716:Nlrp3 protein, mouse; D009822:Oils, Volatile; D052638:Particulate Matter