title: Perilipin polymorphisms are risk factors for the development of obesity in adolescents? A case-control study.
abstract: BACKGROUND
  The variations in perilipin gene (PLIN) were previously associated with obesity. We examined the association of polymorphisms at the PLIN locus in adolescents with obesity and their connection with serum adipokines.
  
  
  METHODS
  A total of 308 children (206 obese, 66.8% and 102 healthy control, 33.2%) between the ages of 10-18 years were included into the study. PLIN gene analysis [PLIN 1, PLIN 4, PLIN 6, PLIN 5'UTR-1234 C > G and PLIN 10171 A/T] were studied by Real Time-PCR. Serum leptin, adiponectin, resistin and ghrelin levels were studied by ELISA method in both groups and their link with perilipin polymorphisms were analyzed.
  
  
  RESULTS
  Serum leptin level was found significantly high in obese adolescents. Other adipokine levels were similar in both groups. The incidence of PLIN 1, PLIN 4, PLIN 5'UTR-1234 C > G and PLIN 10171 A/T minor and major alleles was similar in both groups. PLIN 6 T/T allele was determined significantly high in obese adolescents compared to that of control group. No correlation was detected between perilipin polymorphism and serum levels of adipokines.
  
  
  CONCLUSIONS
  The PLIN 6 polymorphism of the perilipin gene may influence the risk of the obesity during adolescence.
  
  
  BACKGROUND
  Retrospectively registered.
authors.affiliation: Department of Pediatric Gastroenterology, Hepatology and Nutrition, Dokuz Eylul University Faculty of Medicine, 35330, Inciraltı-Izmir, Turkey. drytokgoz@yahoo.com.
authors.forename: Yavuz
authors.identifier: http://orcid.org/0000-0003-2348-9788
authors.initials: Y
authors.lastname: Tokgöz
authors.affiliation: Department of Pediatric Gastroenterology, Hepatology and Nutrition, Dokuz Eylul University Faculty of Medicine, 35330, Inciraltı-Izmir, Turkey.
authors.forename: Ishak Abdurrahman
authors.initials: IA
authors.lastname: Işık
authors.affiliation: Department of Medical Biology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Soheil
authors.initials: S
authors.lastname: Akbari
authors.affiliation: Department of Biochemistry, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Kume
authors.affiliation: Research Laboratory, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Oya
authors.initials: O
authors.lastname: Sayın
authors.affiliation: Department of Medical Biology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Erdal
authors.affiliation: Department of Pediatric Metabolism and Nutrition, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Nur
authors.initials: N
authors.lastname: Arslan
mesh_terms: D054392:Adipokines / Q000097:blood; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D063766:Pediatric Obesity / Q000097:blood / Q000235:genetics*; D000070137:Perilipins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D054392:Adipokines; D000070137:Perilipins
keywords: Adipokines; Adolescent; Obesity; Perilipin polimorphisms