title: Is anti-Mullerian hormone an indicator of potential polycystic ovary syndrome in prepubertal girls with simple obesity?
abstract: The aim of this anti-Mullerian hormone (AMH) levels in prepubertal obese girls are a predictive marker for polycystic ovary syndrome (PCOS) and to investigate the relationship between insulin resistance and AMH. Sixty girls with premature pubarche or obesity and 20 healthy controls between the ages of 6-9 were enrolled. Of the patients, 22 (36.7%) were in the obese group (Group 1), 28 (46.7%) in the early pubarche group (Group 2) and 10 (16.6%) in the early pubarche + obese group (Group 3). Comparison of the subjects' fasting insulin and homeostatic model assessment insulin resistance (HOMA-IR) demonstrated significantly higher values for group 1 compared to group 2 (p=0.001 and 0.001) and, likewise, significantly higher values for group 3 compared to group 2. There was no significant differences between all groups for AMH levels. AMH levels were not significantly different in the obese girls compared to the other groups. There was also no relationship between AMH and insulin resistance in any of the groups. Further studies, however, are needed due the limited number of subjects in this study and in the absence of adequate relevant data.
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Korkmaz
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Damla
authors.initials: D
authors.lastname: Gökşen
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Samim
authors.initials: S
authors.lastname: Özen
authors.forename: Şükran
authors.initials: Ş
authors.lastname: Darcan
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D009765:Obesity / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications
chemical_list: D015415:Biomarkers; D007328:Insulin; D054304:Anti-Mullerian Hormone
keywords: antimullerian hormone; early pubarche; obesity; polycystic ovary syndrome