title: Acute myocardial infarction in a patient suffering from penicillin-induced laryngeal edema : Kounis syndrome aggravated by adrenaline.
abstract: Kounis syndrome or allergic angina is defined as the coincidental occurrence of chest pain and allergic reactions accompanied by clinical and laboratory findings of classical angina pectoris. It is triggered by the action of potent vasoactive and inflammatory mediators, which are released from the mast cells during the allergic reaction. Epinephrine is a life-saving medication in anaphylaxis; however, it can aggravate ischemia and induce coronary vasospasm and arrhythmias. Here, we present a patient with Kounis syndrome that was caused by intramuscular injection of procaine penicillin G, and in whom epinephrine administration for treatment of laryngeal edema had provoked severe myocardial ischemia.
authors.affiliation: Department of Cardiology, Kars Harakani State Hospital, Kars, Turkey. mahmutyesin@yahoo.com.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Yesin
authors.affiliation: Department of Cardiology, İskilip Atıf Hoca State Hospital, Çorum, Turkey.
authors.forename: Macit
authors.initials: M
authors.lastname: Kalçık
authors.affiliation: Department of Cardiology, Gaziemir State Hospital, İzmir, Turkey.
authors.forename: Mustafa Ozan
authors.initials: MO
authors.lastname: Gürsoy
authors.affiliation: Department of Cardiology, Kars Kafkas University, Faculty of Medicine, Kars, Turkey.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Karakoyun
authors.affiliation: Department of Cardiology, Kars Kafkas University, Faculty of Medicine, Kars, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Çağdaş
authors.affiliation: Department of Cardiology, Kosuyolu Kartal Heart Training and Research Hospital, Istanbul, Turkey.|Division of Health Sciences, University of Ardahan, Ardahan, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Özkan
mesh_terms: D000208:Acute Disease; D017023:Coronary Angiography; D004342:Drug Hypersensitivity / Q000150:complications* / Q000188:drug therapy*; D004452:Echocardiography; D004562:Electrocardiography / Q000187:drug effects; D004837:Epinephrine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007273:Injections, Intramuscular; D000074962:Kounis Syndrome / Q000175:diagnosis / Q000209:etiology*; D007819:Laryngeal Edema / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D010402:Penicillin G Procaine / Q000008:administration & dosage / Q000009:adverse effects*; D014069:Tonsillitis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D010402:Penicillin G Procaine; D004837:Epinephrine
keywords: Acute myocardial infarction; Allergic angina; Epinephrine; Kounis syndrome; Penicillin allergy