title: Characteristics of premenstrual acne flare-up and benefits of a dermocosmetic treatment: a double-blind randomised trial.
abstract: To date, facial acne flare-ups in adult women during the luteal phase of the menstrual cycle have been poorly investigated. To clinically characterize premenstrual acne flare-up in adult women and investigate the effect of a dermocosmetic treatment. This single-centre study included 32 young adult women with declared premenstrual acne flares and was composed of two phases: (1) an observational phase (two menstrual cycles) and (2) an interventional phase (one menstrual cycle) in a controlled, randomised, double-blind, intra-individual (half-face) setting in which a dermocosmetic (containing lipohydroxyacid, nicotinamide, and piroctone-olamine) and placebo were compared. Initially, during the first part of the study, we observed that premenstrual acne flare-ups in adult women were characterized by a significant increase in the number of papules (20.2 vs. 13.7; p = 0.0008) and to a lesser extent, closed comedones (25.6 vs. 22.7; p = 0.04). Secondly, during the interventional phase, the half-face treated with the dermocosmetic formulation showed a significantly lower number of inflammatory lesions (7.6 vs 9.4; p = 0.01) during the luteal phase compared to the half-face treated with the placebo. Tolerance of the dermocosmetic formulation was rated as good or excellent. Our data indicate a significant increase in the number of papules during premenstrual acne flare-ups in adult women and the use of a dermocosmetic may be of benefit in partially reducing this premenstrual inflammatory flare-up.
authors.affiliation: Dermatology department, Nantes University Hospital, 1 place A. Ricordeau, 44093 Nantes, France, CRCNA, Inserm U892, CNRS 6299, 9 quai Moncousu, 44093 Nantes Cedex 1, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Saint-Jean
authors.affiliation: Dermatology department, Nantes University Hospital, 1 place A. Ricordeau, 44093 Nantes, France, CRCNA, Inserm U892, CNRS 6299, 9 quai Moncousu, 44093 Nantes Cedex 1, France.
authors.forename: Amir
authors.initials: A
authors.lastname: Khammari
authors.affiliation: La Roche-Posay Dermatological Laboratories, 110 avenue Henri-Barbusse, 92602 Asnières Cedex, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Seite
authors.affiliation: La Roche-Posay Dermatological Laboratories, 110 avenue Henri-Barbusse, 92602 Asnières Cedex, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Moyal
authors.affiliation: Dermatology department, Nantes University Hospital, 1 place A. Ricordeau, 44093 Nantes, France, CRCNA, Inserm U892, CNRS 6299, 9 quai Moncousu, 44093 Nantes Cedex 1, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Dreno
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000068937:Cosmeceuticals / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D004983:Ethanolamines / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008183:Luteal Phase; D009536:Niacinamide / Q000009:adverse effects / Q000627:therapeutic use*; D011728:Pyridones / Q000009:adverse effects / Q000627:therapeutic use*; D012459:Salicylates / Q000009:adverse effects / Q000627:therapeutic use*; D000067251:Symptom Flare Up; D055815:Young Adult
chemical_list: C113468:2-hydroxy-5-octanoylbenzoic acid; D000068937:Cosmeceuticals; D004338:Drug Combinations; D004983:Ethanolamines; D011728:Pyridones; D012459:Salicylates; D009536:Niacinamide; C052599:piroctone olamine
keywords: adult women acne; dermocosmetic; premenstrual flare-up