title: Recent mass spectrometry-based proteomics for biomarker discovery in lung cancer, COPD, and asthma.
abstract: Lung cancer and related diseases have been one of the most common causes of deaths worldwide. Genomic-based biomarkers may hardly reflect the underlying dynamic molecular mechanism of functional protein interactions, which is the center of a disease. Recent developments in mass spectrometry (MS) have made it possible to analyze disease-relevant proteins expressed in clinical specimens by proteomic challenges. Areas covered: To understand the molecular mechanisms of lung cancer and its subtypes, chronic obstructive pulmonary disease (COPD), asthma and others, great efforts have been taken to identify numerous relevant proteins by MS-based clinical proteomic approaches. Since lung cancer is a multifactorial disease that is biologically associated with asthma and COPD among various lung diseases, this study focused on proteomic studies on biomarker discovery using various clinical specimens for lung cancer, COPD, and asthma. Expert commentary: MS-based exploratory proteomics utilizing clinical specimens, which can incorporate both experimental and bioinformatic analysis of protein-protein interaction and also can adopt proteogenomic approaches, makes it possible to reveal molecular networks that are relevant to a disease subgroup and that could differentiate between drug responders and non-responders, good and poor prognoses, drug resistance, and so on.
authors.affiliation: a Department of Translational Medicine Informatics , St. Marianna University School of Medicine, Miyamae-ku , Kawasaki , Japan.
authors.forename: Kiyonaga
authors.initials: K
authors.lastname: Fujii
authors.affiliation: a Department of Translational Medicine Informatics , St. Marianna University School of Medicine, Miyamae-ku , Kawasaki , Japan.|b Department of Chest Surgery , St. Marianna University School of Medicine, Miyamae-ku , Kawasaki , Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Nakamura
authors.affiliation: a Department of Translational Medicine Informatics , St. Marianna University School of Medicine, Miyamae-ku , Kawasaki , Japan.
authors.forename: Toshihide
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D001249:Asthma / Q000235:genetics* / Q000473:pathology; D015415:Biomarkers; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D013058:Mass Spectrometry; D040901:Proteomics / Q000379:methods*; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics* / Q000473:pathology
chemical_list: D015415:Biomarkers
keywords: Biomarkers; COPD; asthma; clinical proteomics; clinical specimens; diagnosis; lung cancer; mass spectrometry; protein–protein interaction network; proteogenomics