title: Investigation of the Mesoporous Metal-Organic Framework as a New Platform To Study the Transport Phenomena of Biomolecules.
abstract: Mesoporous materials, Tb-mesoMOF and MCM-41, were used to study the transport phenomena of biomolecules entering the interior pores from solution. Vitamins B12and B2were successfully encapsulated into these mesoporous materials, whereas Tb-mesoMOF (0.33 g of B12/g, 0.01 g of B2/g) adsorbed a higher amount of vitamin per mass than MCM-41 (0.21 g of B12/g, 0.002 g of B2/g). The diffusion mechanism of the biomolecules entering Tb-mesoMOF was evaluated using a mathematical model. The Raman spectroscopy studies showed vitamin B12has been encapsulated within Tb-mesoMOF's pores, and evaluation of the peak shifts indicated strong interactions linking vitamin B12's pyrroline moiety with Tb-mesoMOF's triazine and benzoate rings. Because of these stronger interactions between the vitamins and Tb-mesoMOF, longer egress times were observed than with MCM-41.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Nankai University , Tianjin 300350, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Seongmin
authors.initials: S
authors.lastname: Hong
authors.affiliation: Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.|Department of Chemistry, Chung Yuan Christian University , 200 Chung Pei Road, Chung-Li 320, Taiwan, ROC.
authors.forename: Chung-Wei
authors.initials: CW
authors.lastname: Fu
authors.affiliation: Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Tran
authors.initials: T
authors.lastname: Hoang
authors.affiliation: Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Veronica
authors.initials: V
authors.lastname: Valencia
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Nankai University , Tianjin 300350, China.|Department of Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Zhenjie
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Jason A
authors.identifier: http://orcid.org/0000-0003-4894-3561
authors.initials: JA
authors.lastname: Perman
authors.affiliation: Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Shengqian
authors.identifier: http://orcid.org/0000-0002-1897-7069
authors.initials: S
authors.lastname: Ma
keywords: Raman spectroscopy; biomolecules; mesoporous metal−organic framework; transport phenomena; vitamin B12 and B2