title: Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma.
abstract: Exosomes are important in intercellular communication. They assure the horizontal transfer of specific functional contents (i.e., proteins, lipids, RNA molecules, and circulating DNA) from donor to recipient cells. Notably, tumor-derived exosomes (TDEs) appear to be an important vehicle of specific signals in cancer, impacting on tumor growth and metastasis. Recent researches point to the characterization of exosomes in Hepatocellular Carcinoma (HCC), the major adult liver malignancy. In this review, we summarize current findings on HCC exosomes, focusing on the identification of noncoding RNAs as exosome-enriched functional regulators and new potential biomarkers. The great potential of exosomes in future HCC diagnostic and therapeutic approaches is underlined.
authors.affiliation: National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy.
authors.forename: Laura
authors.identifier: 0000-0002-9432-262X
authors.initials: L
authors.lastname: Santangelo
authors.affiliation: Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy.
authors.forename: Cecilia
authors.identifier: 0000-0002-5611-7377
authors.initials: C
authors.lastname: Battistelli
authors.affiliation: National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Montaldo
authors.affiliation: Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy.
authors.forename: Franca
authors.identifier: 0000-0001-9946-6190
authors.initials: F
authors.lastname: Citarella
authors.affiliation: Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Strippoli
authors.affiliation: Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy.
authors.forename: Carla
authors.identifier: 0000-0003-4662-5674
authors.initials: C
authors.lastname: Cicchini
mesh_terms: D000328:Adult; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D055354:Exosomes; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*