title: Voice outcomes for early laryngeal cancer.
abstract: OBJECTIVE
  Treatment options for early laryngeal cancer are well established with good local control and 5-year survival. The commonest treatments are radiotherapy or transoral laser microsurgery (TLM). There are advantages and disadvantages of the different modalities, but debate continues regarding the voice outcomes posttreatment. This review will focus on early glottic carcinoma and voice outcomes following the different treatments.
  
  
  RESULTS
  TLM and radiotherapy are both likely to affect voice quality, but the extent of voice change depends on different factors. These factors can be divided into patient, tumour and treatment factors. Recent meta-analyses data show similar voice outcomes for either modality in the treatment of early glottic carcinoma. However, larger tumours and those involving the anterior commissure are associated with worse voice outcomes.
  
  
  CONCLUSIONS
  There are various considerations for the patient and clinician before deciding on the preferred treatment for early glottic carcinoma. Although both TLM and radiotherapy will affect voice outcomes, the recent meta-analyses show similar voice outcomes for either modality in the treatment of early glottic carcinoma. There are numerous variables in the published studies hindering direct comparisons. These include heterogeneous patient groups, different treatment standardization and methods of voice analysis.
authors.affiliation: aDepartment of otolaryngology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London bThe Clatterbridge Cancer Centre NHS Foundation Trust, Birkenhead cNWCR Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool dDepartment of otolaryngology and Head & Neck Surgery, Aintree University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Kinshuck
authors.forename: Aditya
authors.initials: A
authors.lastname: Shenoy
authors.forename: Terry M
authors.initials: TM
authors.lastname: Jones
mesh_terms: D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D015201:Meta-Analysis as Topic; D008866:Microsurgery; D016896:Treatment Outcome; D014833:Voice Quality