title: Observed-to-expected MRI fetal lung volume can predict long-term lung morbidity in infants with congenital diaphragmatic hernia.
abstract: OBJECTIVE
  Congenital diaphragmatic hernia (CDH) causes pulmonary hypoplasia and pulmonary hypertension, which are associated with long-term respiratory problems in infants. The aim of this study was to establish a marker for predicting lung function at 1 year of age in infants with CDH.
  
  
  METHODS
  Infants with isolated CDH who were delivered after 35 weeks of gestation from April 2008 to June 2016 at Nagoya University Hospital were registered. Regarding alive infants with CDH, only those who underwent follow-up for at least 1 year were registered. Finally, 48 infants were analyzed in this study.
  
  
  RESULTS
  Gestational age at diagnosis, amniotic lamellar body count at birth, observed-to-expected MRI fetal lung volume (percent FLV), liver herniation, and polyhydramnios were found to be significant parameters for predicting mortality in infants with CDH. Regarding alive infants with CDH, percent FLV was the only significant parameter to predict need for oxygen therapy at 1 year of age (p < .05). There was a significant negative correlation between percent FLV and duration of oxygen therapy in infants with CDH (r = .516, p < .001).
  
  
  CONCLUSIONS
  Percent FLV is a useful predictor of long-term lung morbidity in infants with CDH.
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuda
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kotani
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Mayo
authors.initials: M
authors.lastname: Miura
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Ito
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Shima
authors.initials: S
authors.lastname: Hirako
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakano
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Imai
authors.affiliation: a Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Kikkawa
mesh_terms: D000328:Adult; D005260:Female; D047109:Fetal Development; D005865:Gestational Age; D065630:Hernias, Diaphragmatic, Congenital / Q000150:complications* / Q000000981:diagnostic imaging / Q000401:mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology; D008176:Lung Volume Measurements; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009929:Organ Size; D010102:Oxygen Inhalation Therapy / Q000706:statistics & numerical data; D006831:Polyhydramnios; D011237:Predictive Value of Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D055815:Young Adult
keywords: Congenital diaphragmatic hernia; MRI; fetal lung volume; lung hypoplasia; morbidity