title: Epidemiology of gastroenteropancreatic neuroendocrine neoplasms in Krakow and Krakow district in 2007-2011.
abstract: BACKGROUND
  Gastroenteropancreatic neuroendocrine neoplasms (GEPNEN) are rare and heterogeneous tumours with variable biology. The aim of this study was to evaluate the epidemiology of GEPNEN in the population of Krakow and Krakow district in 2007-2011.
  
  
  METHODS
  The Database of the Chair and Department of Endocrinology, Jagiellonian University Medical College, comprising the data on NEN cases collected from the Endocrinology Department, University Hospital in Krakow and from independent sources: surgery, pathology, and endocrinology departments located in the Krakow area, was searched for cases of GEPNEN patients living in Krakow and Krakow district, diagnosed between 2007 and 2011. Eighty-eight such patients (39 males, 49 females, median age at diagnosis 59 ± 17 years) were identified and characterised.
  
  
  RESULTS
  The mean follow-up time was 2.67 ± 1.6 years. The most frequent primary location of GEPNEN was small intestine (20%), followed by the appendix (18%), stomach (16%), pancreas (16%), rectum (15%), and colon (15%). NENG1 predominated (64%) in the analysed group. Most well-differentiated GEPNEN (63%) were diagnosed at stage I; however, 18% of them were diagnosed at stage IV. Metastases at diagnosis were found in 31% of patients. The GEPNEN incidence rate in 2007-2011 was 2.1/100000 inhabitants/year, without significant increase during the studied period.
  
  
  CONCLUSIONS
  GEPNEN incidence and epidemiology in the population of Krakow and Krakow district is similar to the incidence observed in most European countries. Registers are important tools to evaluate GEPNEN epidemiology. (Endokrynol Pol 2017; 68 (1): 42-46).
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Trofimiuk-Müldner
authors.affiliation: Department of Endocrinology, University Hospital in Krakow, Krakow, Poland. baczynskae@yahoo.com.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Lewkowicz
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Wysocka
authors.forename: Dorota
authors.initials: D
authors.lastname: Pach
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kiełtyka
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Stefańska
authors.forename: Anna
authors.initials: A
authors.lastname: Sowa-Staszczak
authors.forename: Romana
authors.initials: R
authors.lastname: Tomaszewska
authors.forename: Alicja
authors.initials: A
authors.lastname: Hubalewska-Dydejczyk
mesh_terms: D005260:Female; D006801:Humans; D015994:Incidence; D007414:Intestinal Neoplasms / Q000453:epidemiology*; D008297:Male; D018358:Neuroendocrine Tumors / Q000453:epidemiology*; D010190:Pancreatic Neoplasms / Q000453:epidemiology*; D011044:Poland / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000453:epidemiology*
keywords: epidemiology; gastroenteropancreatic neuroendocrine neoplasms; incidence