title: Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: a systematic review.
abstract: OBJECTIVE
  Dialkylcarbomoyl chloride (DACC)-coated dressings (Leukomed Sorbact and Cutimed Sorbact) irreversibly bind bacteria at the wound surface that are then removed when the dressing is changed. They are a recent addition to the wound care professional's armamentarium and have been used in a variety of acute and chronic wounds. This systematic review aims to assess the evidence supporting the use of DACC-coated dressings in the clinical environment.
  
  
  METHODS
  We included all reports of the clinical use of DACC-coated dressings in relation to wound infection. Medline, Embase, CENTRAL and CINAHL databases were searched to September 2016 for studies evaluating the role of DACC-coated dressings in preventing or managing wound infections.
  
  
  RESULTS
  We identified 17 studies with a total of 3408 patients which were included in this review. The DACC-coating was suggested to reduce postoperative surgical site infection rates and result in chronic wounds that subjectively looked cleaner and had less bacterial load on microbiological assessments.
  
  
  CONCLUSIONS
  Existing evidence for DACC-coated dressings in managing chronic wounds or as a surgical site infection (SSI) prophylaxis is limited but encouraging with evidence in support of DACC-coated dressings preventing and treating infection without adverse effects.
authors.affiliation: Clinical Research Fellow, Academic Vascular Surgical Unit, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ, UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Totty
authors.affiliation: Academic Foundation Doctor, Academic Vascular Surgical Unit, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ, UK.
authors.forename: N
authors.initials: N
authors.lastname: Bua
authors.affiliation: Clinical Lecturer, Academic Vascular Surgical Unit, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ, UK.
authors.forename: G E
authors.initials: GE
authors.lastname: Smith
authors.affiliation: Research Fellow, Academic Vascular Surgical Unit, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ, UK.
authors.forename: A E
authors.initials: AE
authors.lastname: Harwood
authors.affiliation: Consultant Vascular Surgeon, Academic Vascular Surgical Unit, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ, UK.
authors.forename: D
authors.initials: D
authors.lastname: Carradice
authors.affiliation: Clinical Lecturer, Academic Vascular Surgical Unit, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ, UK.
authors.forename: T
authors.initials: T
authors.lastname: Wallace
authors.affiliation: Professor of Vascular Surgery and Consultant Vascular Surgeon, Academic Vascular Surgical Unit, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ, UK.
authors.forename: I C
authors.initials: IC
authors.lastname: Chetter
mesh_terms: D000553:Ambulatory Care / Q000379:methods; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001458:Bandages; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000008:administration & dosage*; D009779:Occlusive Dressings; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D006843:Hydrocarbons, Chlorinated
keywords: Cutimed Sorbact; DACC; Leukomed Sorbact; dialkylcarbomoyl chloride; infection