title: The effect of metilpheniydate, risperidone and combination therapy on ECG in children with attention-deficit hyperactivity disorder.
abstract: This study is to investigate ventricular repolarization on electrocardiogram (ECG) in a pediatric population receiving methylphenidate (MPH), risperidone (RIS) and combined therapy.
  
  
  
  A total of 215 patients between 6 and 12years with ADHD/conduct disorder receiving methylphenidate, risperidone and combined therapy for minimum 3months and an untreated ADHD group (n=76) was consecutively included in the study. Twelve lead ECG parameters including mean QT, QTc, T-peak to T-end (TpTe) intervals, TpTe dispersion and TpTe/QT ratio were compared.
  
  
  
  QT interval, and QTc, TpTe interval, TpTe dispersion and TpTe/QTc ratio values for groups receiving RIS, MPH and combined therapy were found to be significantly higher than other groups. Moreover, in the combined therapy group TpTe and TpTe/QTc values were higher than the single drug administration groups (p<0.05). TpTe and TpTe/QT ratio was significantly higher in the RIS group compared to that of the MPH group.
  
  
  
  These results suggested that combined therapy of these drugs had a more prominent impact on the T wave and RIS could be strongly associated with it.
authors.affiliation: Mersin University, Faculty of Medicine, Department of Pediatric Cardiology, TR, Mersin, Turkey. Electronic address: drderyakarpuz@gmail.com.
authors.forename: Derya
authors.initials: D
authors.lastname: Karpuz
authors.affiliation: Mersin University, Faculty of Medicine, Department of Pediatric Cardiology, TR, Mersin, Turkey.
authors.forename: Olgu
authors.initials: O
authors.lastname: Hallioglu
authors.affiliation: Mersin University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, TR, Mersin, Turkey.
authors.forename: Fevziye
authors.initials: F
authors.lastname: Toros
authors.affiliation: Mersin University, Faculty of Medicine, Department of Biostatistics and Medical Informatics, TR, Mersin, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Tasdelen
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage / Q000009:adverse effects*; D011446:Prospective Studies; D018967:Risperidone / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D018967:Risperidone
keywords: ADHD; Drugs; ECG