title: Intravascular large B-cell lymphoma in the United States (US): a population-based study using Surveillance, Epidemiology, and End Results program and National Cancer Database.
abstract: A population-based study of intravascular large B-cell lymphoma (IVLBCL) in the US was conducted to determine incidence, demographic and clinical characteristics, prognostic factors, and survival compared with diffuse large B-cell lymphoma not otherwise specified (DLBCL NOS). In the years 2000-2013, the age-adjusted incidence rate of IVLBCL was 0.095 (case/1,000,000). The incidence of IVLBCL increased significantly from 2000 to 2013 (annual percentage change = 9.84, p = 0.002). We identified 344 patients with IVLBCL. The median age at diagnosis was 70 years. The median 1, 3, and 5-year OS rates for IVLBCL were 66.2, 51.8, and 46.3%, respectively. After propensity matching, the 5-year overall survival of IVLBCL was comparable to DLBCL NOS (46.4 versus 46.5%, p = 0.53). On multivariate analysis advanced age, advanced stage and having Medicaid or Medicare insurance predicted worse OS, whereas female gender and use of radiation therapy predicted better OS.
authors.affiliation: a Gundersen Health System , La Crosse , WI , USA.
authors.forename: Devalkumar J
authors.initials: DJ
authors.lastname: Rajyaguru
authors.affiliation: a Gundersen Health System , La Crosse , WI , USA.
authors.forename: Chaithanya
authors.initials: C
authors.lastname: Bhaskar
authors.affiliation: b Gundersen Lutheran Medical Foundation , La Crosse , WI , USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Borgert
authors.affiliation: b Gundersen Lutheran Medical Foundation , La Crosse , WI , USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Smith
authors.affiliation: a Gundersen Health System , La Crosse , WI , USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Parsons
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001808:Blood Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011159:Population Surveillance; D012307:Risk Factors; D018426:SEER Program; D014481:United States / Q000453:epidemiology
keywords: Non-Hodgkin lymphoma; diffuse large B-cell lymphoma; intravascular lymphoma; rituximab