title: From resection to ablation: A review of resective surgical options for temporal lobe epilepsy and rationale for an ablation-based approach.
abstract: Surgical intervention is of proven benefit in an appropriately selected subset of patients with medically refractory temporal lobe epilepsy. In these patients, a surgical cure both provides the quality of life improvement that comes from seizure freedom as well as a survival benefit. However, patients who undergo open surgical intervention may have a worsening in neurobehavioral outcomes. Laser interstitial thermal therapy (LITT) represents a minimally invasive surgical intervention that has shown promise in improving post-operative neurobehavioral outcomes. Further, the minimally invasive nature of this procedure holds the possibility to shift the significant under-penetration of surgical intervention that exists for eligible medically refractory patients. Herein, we review open surgical resection-based techniques and the clinical data to date for LITT.
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Coyle
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Riley
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: Chengyuan
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: Ashwini
authors.initials: A
authors.lastname: Sharan
mesh_terms: D001921:Brain / Q000601:surgery*; D004833:Epilepsy, Temporal Lobe / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D019635:Neurosurgical Procedures / Q000379:methods; D012640:Seizures / Q000175:diagnosis / Q000601:surgery*; D016896:Treatment Outcome