title: Objective Ventricle Segmentation in Brain CT with Ischemic Stroke Based on Anatomical Knowledge.
abstract: Ventricle segmentation is a challenging technique for the development of detection system of ischemic stroke in computed tomography (CT), as ischemic stroke regions are adjacent to the brain ventricle with similar intensity. To address this problem, we developed an objective segmentation system of brain ventricle in CT. The intensity distribution of the ventricle was estimated based on clustering technique, connectivity, and domain knowledge, and the initial ventricle segmentation results were then obtained. To exclude the stroke regions from initial segmentation, a combined segmentation strategy was proposed, which is composed of three different schemes: (1) the largest three-dimensional (3D) connected component was considered as the ventricular region; (2) the big stroke areas were removed by the image difference methods based on searching optimal threshold values; (3) the small stroke regions were excluded by the adaptive template algorithm. The proposed method was evaluated on 50 cases of patients with ischemic stroke. The mean Dice, sensitivity, specificity, and root mean squared error were 0.9447, 0.969, 0.998, and 0.219 mm, respectively. This system can offer a desirable performance. Therefore, the proposed system is expected to bring insights into clinic research and the development of detection system of ischemic stroke in CT.
authors.affiliation: College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Qian
authors.affiliation: Division of Research and Innovations, Carestream Health, Inc., Rochester, NY 14615, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lin
authors.affiliation: College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Affiliated Hospital of the Changchun University of Chinese Medicine, Changchun 130021, China.
authors.forename: Xinyan
authors.initials: X
authors.lastname: Yue
authors.affiliation: Collaborative Innovation Center of High-End Manufacturing Equipment, Xi'an Jiaotong University, Xi'an 710054, China.
authors.forename: Bingheng
authors.identifier: 0000-0002-9461-8973
authors.initials: B
authors.lastname: Lu
authors.affiliation: Collaborative Innovation Center of High-End Manufacturing Equipment, Xi'an Jiaotong University, Xi'an 710054, China.
authors.forename: Jing
authors.identifier: 0000-0003-4883-9262
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000150:complications* / Q000000981:diagnostic imaging; D002552:Cerebral Ventricles / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011857:Radiographic Image Interpretation, Computer-Assisted; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020521:Stroke / Q000150:complications* / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*