title: Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding.
abstract: The CA3 region of the hippocampus is important for rapid encoding of memory. Computational theories have proposed specific roles in hippocampal function and memory for the sparse inputs from the dentate gyrus to CA3 and for the extended local recurrent connectivity that gives rise to the CA3 autoassociative network. Recently, we have gained considerable new insight into the operation and plasticity of CA3 circuits, including the identification of novel forms of synaptic plasticity and their underlying mechanisms, and structural plasticity in the GABAergic control of CA3 circuits. In addition, experimental links between synaptic plasticity of CA3 circuits and memory are starting to emerge.
authors.affiliation: University of Bordeaux, Interdisciplinary Institute for Neuroscience, Centre National de la Recherche Scientifique (CNRS), F-33000 Bordeaux, France.
authors.forename: Nelson
authors.initials: N
authors.lastname: Rebola
authors.affiliation: University of Bordeaux, Interdisciplinary Institute for Neuroscience, Centre National de la Recherche Scientifique (CNRS), F-33000 Bordeaux, France.
authors.forename: Mario
authors.initials: M
authors.lastname: Carta
authors.affiliation: University of Bordeaux, Interdisciplinary Institute for Neuroscience, Centre National de la Recherche Scientifique (CNRS), F-33000 Bordeaux, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Mulle
mesh_terms: D000818:Animals; D056654:CA3 Region, Hippocampal / Q000502:physiology*; D003712:Dendrites / Q000502:physiology; D059330:GABAergic Neurons / Q000502:physiology; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D009434:Neural Pathways / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*