title: [The pathology and genetic background of lymphoplasmacytic lymphoma/Waldenström macroglobulinaemia].
abstract: Lymphoplasmacytic lymphoma is a rare low-grade B-cell lymphoma, which is composed of a mixture of small lymphocytes, plasmacytoid cells and plasma cells that typically infiltrate the bone marrow, but lymph nodes and rarely other organs can be involved as well. Waldenström macroglobulinaemia is a lymphoplasmacytic lymphoma with typical bone marrow involvement and is associated with detectable IgM paraproteins. The diagnosis of lymphoplasmacytic lymphoma/Waldenström macroglobulinaemia (LPL/WM) can be challenging, due to similarities to other small B-cell lymphomas with plasmacytic differentiation and/or with IgM paraproteins. The recently discovered MYD88 mutation may help in the diagnosis, as it is present in over 90% of LPL/WMs. This short review covers the pathology of LPL/WM and offers some insight into the new molecular findings that may help in the diagnostic procedure and in the new therapeutic choices.
authors.affiliation: I. Sz. Patológiai és Kísérleti Rákkutató Intézet, Semmelweis Egyetem, Budapest, Hungary. timar.botond@med.semmelweis-univ.hu.
authors.forename: Botond
authors.initials: B
authors.lastname: Timár
mesh_terms: D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology / Q000628:therapy; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics; D010950:Plasma Cells / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics* / Q000473:pathology* / Q000628:therapy
chemical_list: D053594:Myeloid Differentiation Factor 88