title: Unraveling new functions of superoxide dismutase using yeast model system: Beyond its conventional role in superoxide radical scavenging.
abstract: To deal with chemically reactive oxygen molecules constantly threatening aerobic life, cells are readily equipped with elaborate biological antioxidant systems. Superoxide dismutase is a metalloenzyme catalytically eliminating superoxide radical as a first-line defense mechanism against oxidative stress. Multiple different SOD isoforms have been developed throughout evolution to play distinct roles in separate subcellular compartments. SOD is not essential for viability of most aerobic organisms and intriguingly found even in strictly anaerobic bacteria. Sod1 has recently been known to play important roles as a nuclear transcription factor, an RNA binding protein, a synthetic lethal interactor, and a signal modulator in glucose metabolism, most of which are independent of its canonical function as an antioxidant enzyme. In this review, recent advances in understanding the unconventional role of Sod1 are highlighted and discussed with an emphasis on its genetic crosstalk with DNA damage repair/checkpoint pathways. The budding yeast Saccharomyces cerevisiae has been successfully used as an efficient tool and a model organism to investigate a number of novel functions of Sod1.
authors.affiliation: College of Pharmacy, Duksung Women's University, Seoul, 01369, Republic of Korea. whchung23@duksung.ac.kr.|Innovative Drug Center, Duksung Women's University, Seoul, 01369, Republic of Korea. whchung23@duksung.ac.kr.
authors.forename: Woo-Hyun
authors.initials: WH
authors.lastname: Chung
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D020033:Protein Isoforms; D016601:RNA-Binding Proteins / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000378:metabolism*; D000072105:Superoxide Dismutase-1 / Q000378:metabolism*; D014157:Transcription Factors
chemical_list: D000975:Antioxidants; D020033:Protein Isoforms; D016601:RNA-Binding Proteins; D017382:Reactive Oxygen Species; D014157:Transcription Factors; D000072105:Superoxide Dismutase-1
keywords: Saccharomyces cerevisiae; genome stability; reactive oxygen species; superoxide dismutase; synthetic lethal interaction