title: Impact of haemostatic mechanisms on pathophysiology of preeclampsia.
abstract: Preeclampsia (PE) is disorder of new onset hypertension and proteinuria during the second half of pregnancy. There is increasing evidence to implicate placental over-expression of tissue factor and PAR-1 in the pathophysiology of PE. Excessive activation of platelets, neutrophils and the complement system may also contribute to the placental pathology and maternal endothelial responsible for the symptoms of PE. Increased knowledge in this field may identify new therapeutic strategies for the treatment of PE.
authors.affiliation: Haemostasis Research Unit, Department of Haematology, University College London, United Kingdom. Electronic address: c.gardiner@ucl.ac.uk.
authors.forename: Chris
authors.initials: C
authors.lastname: Gardiner
authors.affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom.
authors.forename: Manu
authors.initials: M
authors.lastname: Vatish
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000032:analysis / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology / Q000473:pathology; D003167:Complement Activation; D005260:Female; D006487:Hemostasis; D006801:Humans; D009504:Neutrophils / Q000276:immunology / Q000473:pathology; D010920:Placenta / Q000276:immunology / Q000503:physiopathology*; D015539:Platelet Activation; D011225:Pre-Eclampsia / Q000097:blood* / Q000276:immunology / Q000503:physiopathology*; D011247:Pregnancy; D013925:Thromboplastin / Q000032:analysis / Q000276:immunology; D014327:Trophoblasts / Q000276:immunology / Q000473:pathology
chemical_list: D017152:Antibodies, Antiphospholipid; D013925:Thromboplastin
keywords: Haemostasis; Platelets; Preeclampsia; Syncytiotrophoblast; Tissue factor