title: Structural characterization and bioavailability of ternary nanoparticles consisting of amylose, α-linoleic acid and β-lactoglobulin complexed with naringin.
abstract: Naringin is a bioflavonoid that is rich in citrus plants and possesses enormous health benefits. However, the use of naringin as a nutraceutical is significantly limited by its low bioavailability. In this study, a novel water-soluble ternary nanoparticle material consisting of amylose, α-linoleic acid and β-lactoglobulin was developed to encapsulate naringin to improve its bioavailability. The physicochemical characteristics of the ternary nanoparticle-naringin inclusion complex were analysed by ultraviolet-visible spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), high-resolution transmission electron microscopy (TEM), X-ray diffractometry (XRD) and particle size distribution. The results confirmed the formation of the ternary nanoparticle-naringin inclusion complex. The encapsulation efficiency (EE) and loading content (LC) of the ternary nanoparticle-naringin inclusion complex were 78.73±4.17% and 14.51±3.43%, respectively. In addition, the results of the ternary nanoparticle-naringin inclusion complex in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) demonstrated that naringin can be gradually released from the complex. In conclusion, ternary nanoparticles are considered promising carriers to effectively improve the bioavailability of naringin.
authors.affiliation: School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Haiquan Road, Shanghai 201418, China. Electronic address: fengtao@sit.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.affiliation: School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Haiquan Road, Shanghai 201418, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.affiliation: School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Haiquan Road, Shanghai 201418, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Roha USA, St Louis, MO 63110, USA.
authors.forename: Ran
authors.initials: R
authors.lastname: Ye
authors.affiliation: Research Computing, Information Technology at Purdue (ITaP), Purdue University, 155 South Grant Street, West Lafayette, IN 47907-2114, USA.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, National Engineering Research Center of Edible Fungi, Shanghai 201403, China.
authors.forename: Haining
authors.initials: H
authors.lastname: Zhuang
authors.affiliation: School of Nutrition and Food Sciences, Louisiana State University Agricultural Center, Baton Rouge, LA 70803, USA.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Xu
mesh_terms: D000688:Amylose / Q000737:chemistry*; D000818:Animals; D001682:Biological Availability; D040761:Biomimetic Materials / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D044950:Flavanones / Q000737:chemistry* / Q000493:pharmacokinetics*; D041981:Gastrointestinal Tract / Q000378:metabolism; D006801:Humans; D007782:Lactoglobulins / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D014867:Water / Q000737:chemistry; D017962:alpha-Linolenic Acid / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D044950:Flavanones; D007782:Lactoglobulins; D014867:Water; D017962:alpha-Linolenic Acid; D000688:Amylose; C005274:naringin
keywords: Bioavailability; Inclusion complex; Naringin; Structural characterization; Ternary nanoparticles