title: Role of serum levels of irisin and oxidative stress markers in pregnant women with and without gestational diabetes.
abstract: Irisin regulates glucose levels, lipid levels, insulin sensitivity, and low-grade inflammation. Gestational diabetes mellitus (GDM) is a common metabolic complication of pregnancy, and is associated with increased rates of perinatal problems. Oxidative stress biomarkers have a role in the pathogenesis of patients with GDM. In total, 94 patients were included in our study including 46 control patients and 48 patients with GDM. Fasting blood glucose, HOMA-IR, total oxidative stress (TOS), irisin, and oxidative stress index (OSI) levels of the patients were measured. Serum OGTT, OSI, irisin HOMA, TOS, and insulin levels were statistically significantly higher in the patient group than in the control group. This was the first study to investigate the relation between serum irisin levels and oxidative stress markers in patients with GDM. The results revealed that irisin is an oxidative stress marker and a metabolic protective hormone.
authors.affiliation: a Department of Obstetrics and Gynecology , Medikal Park Hospital , Gaziantep , Turkey.
authors.forename: Betül
authors.initials: B
authors.lastname: Usluoğullari
authors.affiliation: b Department of Endocrinology and Metabolism , Medikal Park Hospital , Gaziantep , Turkey.
authors.forename: Celil Alper
authors.initials: CA
authors.lastname: Usluogullari
authors.affiliation: c Department of Endocrinology and Metabolism , Medicana Hospital , İstanbul , Turkey , and.
authors.forename: Fevzi
authors.initials: F
authors.lastname: Balkan
authors.affiliation: d Department of Biochemistry , Sehitkamil State Hospital , Gaziantep , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Orkmez
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D018384:Oxidative Stress; D011247:Pregnancy; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; C577593:FNDC5 protein, human; D005353:Fibronectins
keywords: Gestational diabetes mellitus; irisin; oxidative stress biomarkers