title: Comparison of viscoelastic property characterization of plastisol phantoms with magnetic resonance elastography and high-frequency rheometry.
abstract: This study aims at evaluating Magnetic Resonance Elastography (MRE) as a reliable technique for the characterization of viscoelastic properties of soft tissues. Three phantoms with different concentrations of plastisol and softener were prepared in order to mechanically mimic a broad panel of healthy and pathological soft tissues. Once placed in a MRI device, each sample was excited by a homemade external driver, inducing shear waves within the medium. The storage (G') and loss (G") moduli of each phantom were then reconstructed from MRE acquisitions over a frequency range from 300 to 1,000 Hz, by applying a 2D Helmholtz inversion algorithm. At the same time, mechanical tests were performed on four samples of each phantom with a High-Frequency piezo-Rheometer (HFR) over an overlapping frequency range (from 160 to 630 Hz) with the same test conditions (temperature, ageing). The comparison between both techniques shows a good agreement in the measurement of the storage and loss moduli, underlying the capability of MRE to noninvasively assess the complex shear modulus G* of a medium and its interest for investigating the viscoelastic properties of living tissues. Moreover, the phantoms with varying concentrations of plastisol used in this study show interesting rheological properties, which make them good candidates to simulate the broad variety of viscoelastic behaviors of healthy and pathological soft tissues.
authors.forename: P M
authors.initials: PM
authors.lastname: Lefebvre
authors.forename: K Tse Ve
authors.initials: KT
authors.lastname: Koon
authors.forename: E
authors.initials: E
authors.lastname: Brusseau
authors.forename: S
authors.initials: S
authors.lastname: Nicolle
authors.forename: J-F
authors.initials: JF
authors.lastname: Palieme
authors.forename: S A
authors.initials: SA
authors.lastname: Lambert
authors.forename: D
authors.initials: D
authors.lastname: Grenier
mesh_terms: D004548:Elasticity; D054459:Elasticity Imaging Techniques; D006801:Humans; D008279:Magnetic Resonance Imaging; D019047:Phantoms, Imaging; D014783:Viscosity