title: Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress.
abstract: Other than genetic regulation of salt sensitivity of blood pressure, many factors have been shown to regulate renal sodium handling which contributes to long-term blood pressure regulation and have been extensively reviewed. Here we present our progress on the Na/K-ATPase signaling mediated sodium reabsorption in renal proximal tubules, from cardiotonic steroids-mediated to reactive oxygen species (ROS)-mediated Na/K-ATPase signaling that contributes to experimental salt sensitivity.
authors.affiliation: Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA. liuj@marshall.edu.
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA. Yan@marshall.edu.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA. Niey@marshall.edu.
authors.forename: Ying
authors.initials: Y
authors.lastname: Nie
authors.affiliation: Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Shapiro
keywords: Na/K-ATPase; ROS; cardiotonic steroids; renal sodium handling; salt sensitivity; signaling