title: Clinico-Pathological Spectrum of Ophthalmic Lesions: An Experience in Tertiary Care Hospital of Central India.
abstract: BACKGROUND
  Ophthalmic lesions show varied distribution on the basis of geographical location. Eye being a unique sensory organ needs to be studied both clinically and pathologically.
  
  
  OBJECTIVE
  This study was aimed to evaluate the histomorphological and clinico-pathlological spectrum of ophthalmic lesions at a tertiary care hospital of Central India.
  
  
  METHODS
  We reviewed all the ophthalmic biopsies performed in the Department of Pathology of our institute between January 2008 and November 2014. Total 488 biopsies of the orbito-ocular region were obtained from patients attending the ophthalmology department. Ophthalmic biopsies were studied as per epidemiological and histomorphological data.
  
  
  RESULTS
  The patients ranged in age from one month to 85 years with bimodal distribution. With a male to female ratio of 1:1. Ophthalmic lesions were highest (44.8%) in less than 20 years age group. Eyelid (33.6%) was the most commonly involved site. Clinical diagnosis was consistent with histopathological diagnosis in approximately 76% cases. The non-neoplastic, benign and malignant lesions were 61.1%, 7.8% and 31.1% respectively. Retinoblastoma formed 40.1% of all malignant lesions followed by sebaceous carcinoma (19.1%) and Squamous Cell Carcinoma (SCC) (10.5%). Rare lesions were primary neuroblastoma of orbit and rhabdomyosarcoma of eyelid.
  
  
  CONCLUSIONS
  Findings suggest that among neoplastic lesions the most common ophthalmic malignancies were retinoblastoma in children and sebaceous carcinoma in adults. Among non-neoplastic lesions, 89% cases of infectious aetiology were of rhinosporidiosis in our study making it an important differential diagnosis among ophthalmic lesions.
authors.affiliation: Senior Resident, Department of Pathology and Lab Medicine, AIIMS , Raipur, Chhattisgarh, India .
authors.forename: Yashita
authors.initials: Y
authors.lastname: Gupta
authors.affiliation: Professor and Head, Department of Pathology, Government Medical College , Rajnandgaon, Chhattisgarh, India .
authors.forename: Renuka
authors.initials: R
authors.lastname: Gahine
authors.affiliation: Associate Professor, Department of Pathology and Lab Medicine, AIIMS , Raipur, Chhattisgarh, India .
authors.forename: Nighat
authors.initials: N
authors.lastname: Hussain
authors.affiliation: Assistant Professor, Department of Pathology, Pt. JNM Medical College , Raipur, Chhattisgarh, India .
authors.forename: Mohd Jafar
authors.initials: MJ
authors.lastname: Memon
keywords: Neuroblastoma; Orbito-ocular lesions; Retinoblastoma; Rhabdomyosarcoma; Rhinosporidiosis