title: Methylene Blue (Tetramethylthionine Chloride) Influences the Mobility of Adult Neural Stem Cells: A Potentially Novel Therapeutic Mechanism of a Therapeutic Approach in the Treatment of Alzheimer's Disease.
abstract: An interest in neurogenesis in the adult human brain as a relevant and targetable process has emerged as a potential treatment option for Alzheimer's disease and other neurodegenerative conditions. The aim of this study was to investigate the effects of tetramethylthionine chloride (methylene blue, MB) on properties of adult murine neural stem cells. Based on recent clinical studies, MB has increasingly been discussed as a potential treatment for Alzheimer's disease. While no differences in the proliferative capacity were identified, a general potential of MB in modulating the migratory capacity of adult neural stem cells was indicated in a cell mobility assay. To our knowledge, this is the first time that MB could be associated with neural mobility. The results of this study add insight to the spectrum of features of MB within the central nervous system and may be helpful for understanding the molecular mechanisms underlying a potential therapeutic effect of MB.
authors.affiliation: Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, LVR Hospital, Essen, Germany.|Department of Medicine, Division of Nephrology, Boston Children's Hospital, Harvard Medical School, MA, USA.
authors.forename: Amelie T
authors.initials: AT
authors.lastname: van der Ven
authors.affiliation: Max-Plank Institute of Psychiatry, Munich, Germany.
authors.forename: Julius C
authors.initials: JC
authors.lastname: Pape
authors.affiliation: Department of Neurology, Chair of Vascular Neurology and Dementia, University Hospital of Essen, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Hermann
authors.affiliation: Sheppard Pratt- Research Institute, Baltimore, MD, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Schloesser
authors.affiliation: Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, LVR Hospital, Essen, Germany.
authors.forename: Just
authors.initials: J
authors.lastname: Genius
authors.affiliation: Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, LVR Hospital, Essen, Germany.
authors.forename: Nadine
authors.initials: N
authors.lastname: Fischer
authors.affiliation: Department of Psychiatry, University of Tübingen, Germany.
authors.forename: Rainald
authors.initials: R
authors.lastname: Mößner
authors.affiliation: Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, LVR Hospital, Essen, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Scherbaum
authors.affiliation: Department of Psychiatry, University of Göttingen, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Wiltfang
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Halle (Saale), Germany.
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
authors.affiliation: Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, LVR Hospital, Essen, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Benninghoff
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D002465:Cell Movement / Q000187:drug effects*; D002478:Cells, Cultured; D002491:Central Nervous System Agents / Q000494:pharmacology*; D018891:Dentate Gyrus / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D015870:Gene Expression / Q000187:drug effects; D007150:Immunohistochemistry; D008751:Methylene Blue / Q000494:pharmacology*; D051379:Mice; D058953:Neural Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
chemical_list: D002491:Central Nervous System Agents; D008751:Methylene Blue
keywords: Adult stem cells; Alzheimer’s disease; methylene blue; neural plasticity