title: Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy.
abstract: Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit growth of different types of malignancies. Additionally, this multifaceted RTK inhibitor was reported to be a tumor suppressor, a stem cell regulator, and a modulator of different cellular phenotypes. This mini-review provides a concise and up-to-date summary about the known functions of LRIG1 and its related family members, with a special emphasis on underlying molecular mechanisms and the opportunities for harnessing its therapeutic potential against cancer.
authors.affiliation: NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, 1526, Luxembourg.
authors.forename: Virginie
authors.initials: V
authors.lastname: Neirinckx
authors.affiliation: Oncology Research Laboratory, Department of Radiation Sciences, Umeå University, 90187 Umeå, Sweden.
authors.forename: Hakan
authors.initials: H
authors.lastname: Hedman
authors.affiliation: NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, 1526, Luxembourg; K.G. Jebsen Brain Tumour Research Centre, Department of Biomedicine, University of Bergen, 5020 Bergen, Norway. Electronic address: simone.niclou@lih.lu.
authors.forename: Simone P
authors.initials: SP
authors.lastname: Niclou
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*
chemical_list: D008562:Membrane Glycoproteins; D047428:Protein Kinase Inhibitors; D020794:Receptor Protein-Tyrosine Kinases
keywords: Cancer; Ectodomain; Leucine-rich repeats and immunoglobulin-like domains containing protein 1; Nervous system; Receptor tyrosine kinase