title: Tyrosine assisted size controlled synthesis of silver nanoparticles and their catalytic, in-vitro cytotoxicity evaluation.
abstract: A simple, green approach for the size controllable preparation of silver nanoparticles (SNPs) using tyrosine as reducing and capping agent is shown here. The size of SNPs is controlled by varying the pH of tyrosine solution. The as synthesized SNPs are characterized by using XRD, UV-Visible, DLS, TEM and SAED. Zeta potential measurements revealed the stability of tyrosine capped silver nanocolloids. Furthermore, catalytic activity studies concluded that the smaller SNPs acts as good catalyst and the catalytic activity depends on size of the nanoparticles. Further, the in-vitro cytotoxicity experiments concluded that the cytotoxicity of the prepared SNPs towards mouse fibroblast (3T3) cell lines is size and dose dependent. Additionally, the present approach is substitute to the traditional methods that are being used now-a-days for size controlled synthesis of SNPs.
authors.affiliation: The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, National Engineering Lab for Textile Fiber Materials and Processing Technology (Zhejiang), College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China; Trace Elements Speciation Research Laboratory, Environmental and Analytical Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, India.
authors.forename: Sireesh Babu
authors.initials: SB
authors.lastname: Maddinedi
authors.affiliation: Trace Elements Speciation Research Laboratory, Environmental and Analytical Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, India. Electronic address: badalmandal@vit.ac.in.
authors.forename: Badal Kumar
authors.initials: BK
authors.lastname: Mandal
authors.affiliation: Trace Elements Speciation Research Laboratory, Environmental and Analytical Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, India.
authors.forename: Kiran Kumar
authors.initials: KK
authors.lastname: Anna
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D055772:Green Chemistry Technology; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D010316:Particle Size; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology*; D013499:Surface Properties; D014443:Tyrosine / Q000737:chemistry*
chemical_list: D012834:Silver; D014443:Tyrosine
keywords: SNPs; Stabilizing agent; Tyrosine