title: Cardiovascular Bio-Engineering: Current State of the Art.
abstract: Despite the introduction of new drugs and innovative devices contributing in the last years to improve patients' quality of life, morbidity and mortality from cardiovascular diseases remain high. There is an urgent need for addressing the underlying problem of the loss of cardiac or vascular tissues and therefore developing new therapies. Autologous vascular transplants are often limited by poor quality of donor sites and heart organ transplantation by donor shortage. Vascular and cardiac tissue engineering, whose aim is to repair or replace cardiovascular tissues by the use of cells, engineering and materials, as well as biochemical and physicochemical factors, appears in this scenario as a promising tool to repair the damaged hearts and vessels. We will present a general overview on the fundamentals in the area of cardiac and vascular tissue engineering as well as on the latest progresses and challenges.
authors.affiliation: Inserm U1148, LVTS, X. Bichat Hospital, University Paris Diderot, 46 rue H Huchard, 75018, Paris, France.|Institut Galilée, University Paris 13, 93430, Villetaneuse, France.
authors.forename: Teresa
authors.initials: T
authors.lastname: Simon-Yarza
authors.affiliation: Inserm U1148, LVTS, X. Bichat Hospital, University Paris Diderot, 46 rue H Huchard, 75018, Paris, France.|Institut Galilée, University Paris 13, 93430, Villetaneuse, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bataille
authors.affiliation: Inserm U1148, LVTS, X. Bichat Hospital, University Paris Diderot, 46 rue H Huchard, 75018, Paris, France. didier.letourneur@inserm.fr.|Institut Galilée, University Paris 13, 93430, Villetaneuse, France. didier.letourneur@inserm.fr.
authors.forename: Didier
authors.identifier: http://orcid.org/0000-0003-2197-9468
authors.initials: D
authors.lastname: Letourneur
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D006348:Cardiac Surgical Procedures / Q000295:instrumentation* / Q000379:methods; D002318:Cardiovascular Diseases / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D009206:Myocardium / Q000473:pathology; D032383:Myocytes, Cardiac / Q000473:pathology / Q000637:transplantation*; D011474:Prosthesis Design; D020127:Recovery of Function; D012038:Regeneration; D044968:Regenerative Medicine / Q000295:instrumentation / Q000379:methods; D033581:Stem Cell Transplantation / Q000379:methods*; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods; D054457:Tissue Scaffolds
keywords: Cardiac repair; Tissue engineering; Vascular prostheses