title: A comparison of copper and acid site zeolites for the production of nitric oxide for biomedical applications.
abstract: Copper-exchanged and acidic zeolites are shown to produce nitric oxide (NO) from a nitrite source in biologically active (nanomolar) concentrations. Four zeolites were studied; mordenite, ferrierite, ZSM-5 and SSZ-13, which had varying pore size, channel systems and Si/Al ratios. ZSM-5 and SSZ-13 produced the highest amounts of NO in both the copper and acid form. The high activity and regeneration of the copper active sites makes them good candidates for long-term NO production. Initial cytotoxicity tests have shown at least one of the copper zeolites (Cu-SSZ-13) to be biocompatible, highlighting the potential usage within biomedical applications.
authors.affiliation: School of Chemistry, University of St. Andrews, Purdie Building, St. Andrews KY16 9ST, UK. sr90@st-andrews.ac.uk rem1@st-andrews.ac.uk.
authors.forename: Samantha E
authors.initials: SE
authors.lastname: Russell
authors.affiliation: Sasol UK Ltd, Purdie Building, St Andrews KY16 9ST, UK.
authors.forename: Juan María
authors.initials: JM
authors.lastname: González Carballo
authors.affiliation: Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK.
authors.forename: Claudia
authors.initials: C
authors.lastname: Orellana-Tavra
authors.affiliation: Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK.
authors.forename: David
authors.identifier: http://orcid.org/0000-0002-5013-1194
authors.initials: D
authors.lastname: Fairen-Jimenez
authors.affiliation: School of Chemistry, University of St. Andrews, Purdie Building, St. Andrews KY16 9ST, UK. sr90@st-andrews.ac.uk rem1@st-andrews.ac.uk.
authors.forename: Russell E
authors.identifier: http://orcid.org/0000-0001-7809-0315
authors.initials: RE
authors.lastname: Morris
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry* / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009569:Nitric Oxide / Q000737:chemistry*; D009573:Nitrites / Q000737:chemistry; D013696:Temperature; D017641:Zeolites / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D009573:Nitrites; D017641:Zeolites; D009569:Nitric Oxide; D003300:Copper