title: Self-reported sleep disturbance and survival in myelodysplastic syndromes.
abstract: Neither the prevalence of sleep disturbance nor its association with fatigue and overall survival (OS) are well understood for patients with myelodysplastic syndromes (MDS). New patients at our institution (n = 251; 2006-2014) completed the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, which includes questions about sleep and fatigue. Fifty-three per cent reported at least 'a little' trouble sleeping. In multivariable models, anaemia and sleep disturbance were associated with fatigue (both P < 0·001). Additionally, in separate models, sleep disturbance (P = 0·002) and fatigue (P = 0·04) both predicted OS. Our data suggest that improving sleep quality may impact MDS-related fatigue and OS.
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.|Harvard Medical School, Boston, MA, USA.
authors.forename: Marlise R
authors.initials: MR
authors.lastname: Luskin
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Angel M
authors.initials: AM
authors.lastname: Cronin
authors.affiliation: University of California, San Diego, San Diego, CA, USA.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Owens
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.|Harvard Medical School, Boston, MA, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: DeAngelo
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.|Harvard Medical School, Boston, MA, USA.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Stone
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.|Harvard Medical School, Boston, MA, USA.
authors.forename: Martha
authors.initials: M
authors.lastname: Wadleigh
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.|Harvard Medical School, Boston, MA, USA.
authors.forename: David P
authors.initials: DP
authors.lastname: Steensma
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.|Harvard Medical School, Boston, MA, USA.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Abel
mesh_terms: D000328:Adult; D000368:Aged; D005221:Fatigue / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000401:mortality; D012307:Risk Factors; D057566:Self Report; D012893:Sleep Wake Disorders / Q000150:complications* / Q000401:mortality
keywords: fatigue; myelodysplastic syndromes; overall survival; quality of life; sleep