title: Lactobacillus rhamnosus GG probiotic enteric regimen does not appreciably alter the gut microbiome or provide protection against GVHD after allogeneic hematopoietic stem cell transplantation.
abstract: Graft-versus-host disease (GVHD) is a major adverse effect associated with allogeneic stem cell transplant. Previous studies in mice indicated that administration of the probiotic Lactobacillus rhamnosus GG can reduce the incidence of GVHD after hematopoietic stem cell transplant. Here we report results from the first randomized probiotic enteric regimen trial in which allogenic hematopoietic stem cell patients were supplemented with Lactobacillus rhamnosus GG. Gut microbiome analysis confirmed a previously reported gut microbiome association with GVHD. However, the clinical trial was terminated when interim analysis did not detect an appreciable probiotic-related change in the gut microbiome or incidence of GVHD. Additional studies are necessary to determine whether probiotics can alter the incidence of GVHD after allogeneic stem cell transplant.
authors.affiliation: Department of Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Elan
authors.initials: E
authors.lastname: Gorshein
authors.affiliation: Department of Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Wei
authors.affiliation: Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Ambrosy
authors.affiliation: Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Shanna
authors.initials: S
authors.lastname: Budney
authors.affiliation: Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Juliana
authors.initials: J
authors.lastname: Vivas
authors.affiliation: Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Angelika
authors.initials: A
authors.lastname: Shenkerman
authors.affiliation: Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Manago
authors.affiliation: Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Mary Kate
authors.initials: MK
authors.lastname: McGrath
authors.affiliation: Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Tyno
authors.affiliation: Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Vimal
authors.initials: V
authors.lastname: Patel
authors.affiliation: Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Mecide
authors.initials: M
authors.lastname: Gharibo
authors.affiliation: Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Dale
authors.initials: D
authors.lastname: Schaar
authors.affiliation: Division of Cancer Medicine, Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Jenq
authors.affiliation: Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Hossein
authors.initials: H
authors.lastname: Khiabanian
authors.affiliation: Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
authors.forename: Roger
authors.identifier: 0000-0002-1881-7989
authors.initials: R
authors.lastname: Strair
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D006086:Graft vs Host Disease / Q000178:diet therapy / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D052201:Lacticaseibacillus rhamnosus / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D019936:Probiotics / Q000008:administration & dosage*; D011379:Prognosis; D014184:Transplantation, Homologous
keywords: graft-versus-host disease; gut microbiome; hematopoietic stem cell transplantation; probiotics