title: Sex Differences in the Effects of Obesity on Lung Volume.
abstract: Obesity is linked to variation of lung volume; however, it is still unclear whether a sex difference exists. The study aimed to find out the effect of obesity on lung volume and sex difference among the Chinese population.
  
  
  
  Pulmonary function test results were collected from 300 patients (aged 18 to ~80 years) with normal airway function and a wide range of body mass indexes (BMI). Measures of total lung capacity, vital capacity (VC), inspiratory capacity (IC), reserve volume, expiratory reserve volume (ERV) and functional reserve capacity (FRC) were analyzed by sex and different BMI groups.
  
  
  
  BMI was correlated with VC inversely and IC positively in liner relationships (VC: r = -0.115, P < 0.05; IC: r = 0.168, P < 0.05, respectively), whereas ERV and FRC decreased exponentially with increasing BMI (FRC: r = -0.298, P < 0.01; ERV: r=-0.348, P < 0.01, respectively). Significant correlations were identified for the effect of BMI on ERV and IC and FRC in females (r = -0.354, P < 0.01; r = 0.206, P < 0.05; r = -0.335, P < 0.01), whereas only on ERV in males (r = -0.230, P < 0.05).
  
  
  
  BMI affected the lung volume, and females were more susceptible to the effects than males.
authors.affiliation: Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Li Na
authors.initials: LN
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Chen Juan
authors.initials: CJ
authors.lastname: Gu
authors.affiliation: Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Jian Ping
authors.initials: JP
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Xian Wen
authors.initials: XW
authors.lastname: Sun
authors.affiliation: Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: liqngyun68@hotmail.com.
authors.forename: Qing Yun
authors.initials: QY
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005105:Expiratory Reserve Volume; D005260:Female; D005652:Functional Residual Capacity; D006801:Humans; D007320:Inspiratory Capacity; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000473:pathology*; D009929:Organ Size; D012727:Sex Characteristics; D014109:Total Lung Capacity; D014797:Vital Capacity; D055815:Young Adult
keywords: Body mass index; Lung volume; Obesity; Sex difference