title: Selective Androgen Receptor Modulator in a Patient With Hormone-Positive Metastatic Breast Cancer.
abstract: Androgen receptors (ARs) are highly coexpressed in estrogen receptor (ER)-positive breast cancers. Their role in breast tumorigenesis has been postulated, but the mechanism is not yet well-characterized. Steroidal androgens were previously used as an anticancer strategy but fell out of favor because of toxicity and the discovery of alternative therapies. Recent attempts to modulate androgen pathway signaling have focused on AR inhibitors. This report discusses a case using a well-tolerated selective AR modulator to treat a highly pretreated patient with ER-positive breast cancer, which resulted in a durable partial response.
authors.affiliation: From the University of Tennessee West Cancer Center, Germantown, Tennessee.
authors.forename: Namratha
authors.initials: N
authors.lastname: Vontela
authors.affiliation: From the University of Tennessee West Cancer Center, Germantown, Tennessee.
authors.forename: Vamsi
authors.initials: V
authors.lastname: Koduri
authors.affiliation: From the University of Tennessee West Cancer Center, Germantown, Tennessee.
authors.forename: Lee S
authors.initials: LS
authors.lastname: Schwartzberg
authors.affiliation: From the University of Tennessee West Cancer Center, Germantown, Tennessee.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Vidal
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011944:Receptors, Androgen / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone