title: Worsening of rest-activity circadian rhythm and quality of life in female breast cancer patients along progression of chemotherapy cycles.
abstract: Chemotherapy and its associated side effects can induce the disruption of circadian rest-activity rhythm and may have negative consequences on health-related quality of life (HRQoL) of cancer patients. In the current study, repeated-measures cross-sectional design was implemented to determine the status of circadian rest-activity rhythm and to assess the HRQoL of newly diagnosed female breast cancer patients those were planned to receive six cycles of chemotherapy. Rest activity and HRQoL were assessed in twenty-five patients during chemotherapy cycles 1st (C1), 3rd (C3), and 6th (C6) immediately after they reported to the outdoor ward of the Regional Cancer Center, Pt. J.N.M. Medical College, Dr. B.R. Ambedkar Memorial Hospital, Raipur, India. Wrist actigraphs for consecutive spans of 3-4 days were used to record the rest-activity rhythm, and its parameters were computed with the help of Cosinor Rhythmometry. Quality of life (QoL) parameters were assessed using EORTC QLQ-C30 and QLQ-BR23. Results revealed that average scores of all rhythm parameters, such as MESOR, amplitude, acrophase, rhythm quotient, circadian quotient, peak activity, dichotomy index, and autocorrelation coefficient; and all functional scales of QLQ-C30, such as physical, role, emotional, cognitive, and social, and global quality of life statistically significantly decreased with the increasing number of chemotherapy cycles (C1 to C3 and C6). Scores of symptom scales of QLQ-C30, such as fatigue, pain, dyspnoea, insomnia, appetite loss, and diarrhea increased significantly from C1 to C6. Among the QLQ-BR23 scales, scores of sexual functioning, sexual enjoyment, breast symptoms, and arm symptoms significantly decreased, whereas scores of systemic therapy side effects, and upset by hair loss significantly increased across the chemotherapy cycles. We conclude that rest-activity rhythm disrupted and HRQoL of breast cancer patients worsened along the increasing number of chemotherapy cycles. We suggest that along with the treatment protocol, level of disruption of these parameters should be assessed and managed with the proper interventions that prominently include timing of the chemotherapy administration. The latter is pivotal for maintenance of these parameters, which are likely to enhance the physiological ability of patients for better treatment responses and may improve the overall QoL and survival of the patients.
authors.affiliation: a Chronobiology and Animal Behavior Laboratory, School of Life Sciences , Pt. Ravishankar Shukla University , Raipur , Chhattisgarh , India.
authors.forename: Armiya
authors.initials: A
authors.lastname: Sultan
authors.affiliation: c Regional Cancer Center, Pt. Jawaharlal Nehru Medical College , Dr. B.R. Ambedkar Memorial Hospital , Raipur , Chhattisgarh , India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Choudhary
authors.affiliation: a Chronobiology and Animal Behavior Laboratory, School of Life Sciences , Pt. Ravishankar Shukla University , Raipur , Chhattisgarh , India.|b Center for Translational Chronobiology, Pt. Ravishankar Shukla University , Raipur , Chhattisgarh , India.
authors.forename: Arti
authors.initials: A
authors.lastname: Parganiha
mesh_terms: D056044:Actigraphy; D000204:Activity Cycles; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002940:Circadian Rhythm; D005221:Fatigue; D005260:Female; D006801:Humans; D008875:Middle Aged; D011788:Quality of Life; D012146:Rest / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents
keywords: Breast cancer; chemotherapy cycle; quality of life; rest-activity rhythm