title: Lymphocyte-specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation.
abstract: Lymphocyte-specific protein 1 (LSP1) has been reported to regulate cell biology in several human cancers including lymphoma and breast cancer. However, the functions of LSP1 in human hepatocellular carcinoma (HCC) are still unknown. In this study, we found that LSP1 expression was downregulated in HCC tissues and cell lines, and lower LSP1 expression was correlated with poor clinicopathological features including large tumor size, high Edmondson-Steiner grading and advanced tumor-node-metastasis (TNM) stage. Additionally, we demonstrated that patients with high LSP1 expression had significantly better overall survival and disease-free survival. Moreover, LSP1 was found to be an independent factor for predicting the prognosis of HCC patients.In vitroandin vivoassays showed that overexpressing LSP1 inhibited HCC growth by inducing both apoptosis and growth arrest. Mechanistically, we found that expression of phosphorylated extracellular regulated protein kinases 1 and 2 (ERK1/2) was downregulated after LSP1 overexpression, indicating LSP1 could suppress HCC growth by inhibiting the ERK pathway in HCC cells. Taken together, these results indicate that LSP1 may serve as a prognostic marker and a potential therapeutic target in human HCC.
authors.affiliation: Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University China.
authors.forename: Hongyong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University China.
authors.forename: Zhikui
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University China.
authors.forename: Bowen
authors.initials: B
authors.lastname: Yao
authors.affiliation: Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University China.
authors.forename: Changwei
authors.initials: C
authors.lastname: Dou
authors.affiliation: Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University China.
authors.forename: Meng
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University China.
authors.forename: Yuli
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University China.
authors.forename: Shengli
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University China.
authors.forename: Kangsheng
authors.initials: K
authors.lastname: Tu
authors.affiliation: Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University China.
authors.forename: Qingguang
authors.initials: Q
authors.lastname: Liu
keywords: apoptosis; extracellular regulated protein kinase pathway; hepatocellular carcinoma; lymphocyte‐specific protein 1; proliferation