title: Dynamic changes of epigenetic signatures during chondrogenic and adipogenic differentiation of mesenchymal stem cells.
abstract: Extensive studies have been performed to clarify the processes during which mesenchymal stem cells (MSCs) differentiate into their lineage fates. In vitro differentiation of MSCs into distinct lineages have attracted the focus of a large number of clinical investigations. Although the gene expression profiling during differentiation of MSC toward bone, cartilage, and adipocytes is well established, the master regulators by which MSC fate can be controlled are not entirely determined. During differentiation of MSCs into a special cell fate, epigenetic mechanisms considered as the primary mediators that suppress the irrelevant genes and activate the genes required for a specific cell lineage. This review dedicated to addressing the changes of various epigenetic mechanisms, including DNA methylation, histone modifications, and micro-RNAs during chondrogenic and adipogenic differentiation of MSC.
authors.affiliation: Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran.
authors.forename: Navid
authors.initials: N
authors.lastname: Saidi
authors.affiliation: Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Majdedin
authors.initials: M
authors.lastname: Ghalavand
authors.affiliation: Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Sadegh
authors.initials: MS
authors.lastname: Hashemzadeh
authors.affiliation: Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: R.dorost@yahoo.com.
authors.forename: Ruhollah
authors.initials: R
authors.lastname: Dorostkar
authors.affiliation: Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Mohammadi
authors.affiliation: Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Mahdian-Shakib
mesh_terms: D050156:Adipogenesis / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D020219:Chondrogenesis / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D059630:Mesenchymal Stem Cells / Q000502:physiology*
keywords: Chondrogenic and adipogenic differentiation; Epigenetics; MSCs