title: Protecting PTEN in the Nucleus.
abstract: A recent study shows that the transport receptor Importin-11 relocates PTEN, a tumor suppressor, to the nucleus, preventing its degradation in the cytoplasm. Mice lacking Importin-11 are prone to lung cancers, and its absence in human prostate and lung tumors signals a poorer prognosis.
mesh_terms: D000818:Animals; D064113:CRISPR-Cas Systems; D002467:Cell Nucleus / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D008297:Male; D051379:Mice; D009362:Neoplasm Metastasis; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D011379:Prognosis; D011467:Prostate; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D015398:Signal Transduction; D044763:Ubiquitin-Conjugating Enzymes / Q000235:genetics*
chemical_list: C489963:UBE2E1 protein, human; D044763:Ubiquitin-Conjugating Enzymes; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human