title: Total Synthesis of Kehokorins A-E, Cytotoxic p-Terphenyls.
abstract: This paper describes a general method for the synthesis of kehokorins A-E, novel cytotoxic p-terphenyls. 2,4,6-Trihydroxybenzaldehyde served as a common building block for preparation of the central aromatic ring. Construction of their p-terphenyl skeletons was achieved by a stepwise Suzuki-Miyaura coupling, whereas the phenyldibenzofuran moiety was built up by an intramolecular Ullmann reaction. Introduction of an l-rhamnose residue into partly protected kehokorin B was performed by the trichloroacetimidate method.
authors.affiliation: RIKEN Center for Sustainable Resource Science , Wako, Saitama 351-0198, Japan.
authors.forename: Shunya
authors.identifier: 0000-0001-9148-9814
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: RIKEN Center for Sustainable Resource Science , Wako, Saitama 351-0198, Japan.|Division of Material Science, Graduate School of Science and Engineering, Saitama University , Saitama 338-8570, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Suda
authors.affiliation: RIKEN Center for Sustainable Resource Science , Wako, Saitama 351-0198, Japan.
authors.forename: Takemichi
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Division of Material Science, Graduate School of Science and Engineering, Saitama University , Saitama 338-8570, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Matsuoka
authors.affiliation: RIKEN Center for Sustainable Resource Science , Wako, Saitama 351-0198, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koshino
mesh_terms: D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013730:Terphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D013730:Terphenyl Compounds