title: Induction of Chiral Recognition with Lipid Nanodomains Produced by Polymerization.
abstract: We report the induction and control of chiral recognition in liposomal membranes by the photopolymerization of diacetylenic lipids (DiynePC). The specific properties of polymerized DiynePC liposomes were characterized, and then the chiral separation performance was estimated. As the polymerization proceeds, chiral recognition to ibuprofen was induced, and its efficiency increased due to the formation of rigid nanodomains and boundary edges. Furthermore, the chiral recognition and adsorbed amount could be controlled by the ratio of rigid nanodomains, varying the composition ratio of DiynePC. Finally, the optimum condition and dominant interactions for enantioselective adsorption were clarified. Thus, our findings and results will be helpful to understand the induction of chiral recognition by polymerizable liposomes, and also become a guideline for the construction of liposomal chiral stationary phases.
authors.affiliation: Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University , 1-3 Machikaneyama-cho, Toyonaka, Osaka 560-8531, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Okamoto
authors.affiliation: Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University , 1-3 Machikaneyama-cho, Toyonaka, Osaka 560-8531, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kishi
authors.affiliation: Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University , 1-3 Machikaneyama-cho, Toyonaka, Osaka 560-8531, Japan.
authors.forename: Keishi
authors.initials: K
authors.lastname: Suga
authors.affiliation: Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University , 1-3 Machikaneyama-cho, Toyonaka, Osaka 560-8531, Japan.
authors.forename: Hiroshi
authors.identifier: 0000-0002-9241-853X
authors.initials: H
authors.lastname: Umakoshi
mesh_terms: D002152:Calorimetry, Differential Scanning; D002462:Cell Membrane / Q000187:drug effects; D007052:Ibuprofen / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry*; D058105:Polymerization
chemical_list: D008055:Lipids; D008081:Liposomes; D007052:Ibuprofen