title: The Role of Serum Fibrinogen Level in the Diagnosis of Acute Appendicitis.
abstract: BACKGROUND
  Acute appendicitis is the most common indication for emergent surgery and affects a wide range of patients at any age group. However, inspite of the presence of various imaging modalities, biochemical markers, and scoring systems the negative appendectomy rate remain high. Serum fibrinogen, an acute inflammatory mediator is usually raised in any acute inflammatory condition and the same is expected to rise in acute appendicitis, which may be used as a new inflammatory marker in the diagnosis and more importantly in decision making of management of acute appendicitis.
  
  
  OBJECTIVE
  To determine the relationship between the rise in the level of serum fibrinogen and acute appendicitis and its role in reducing the negative appendectomy rate.
  
  
  METHODS
  A total of 82 patients with clinical signs and symptoms of acute appendicitis who underwent emergency appendectomy were included in the study, the serum fibrinogen level were measured just before the operation and the sensitivity and the specificity was calculated. The final diagnosis was based on the histopathological examination.
  
  
  RESULTS
  In our study, the Mean±SD of serum fibrinogen in mg/dl in those patient proved to be having acute appendicitis by histopathology was 436.6±40.6 while those with normal appendix was 391.91±66.54. The area under the curve was 0.697 i.e., it has an accuracy of around 70% and this is statistically significant (p=0.018). On further sub-analysis when the cut off level of fibrinogen level was reduced to 397, it resulted in a sensitivity of 82% and specificity of 60% and if the level was further reduced to 375 it increased the sensitivity to 88% with a specificity of 55%.
  
  
  CONCLUSIONS
  In the diagnosis of acute appendicitis, use of fibrinogen blood level may be a new diagnostic acute-phase reactant with possible role in reducing negative appendectomy rate.
authors.affiliation: Junior Resident, Department of General Surgery, Regional Institute of Medical Sciences , Imphal West, Manipur, India .
authors.forename: Kuotho T
authors.initials: KT
authors.lastname: Nyuwi
authors.affiliation: Assistant professor, Department of General Surgery, Regional Institute of Medical Sciences , Imphal West, Manipur, India .
authors.forename: Ch Gyan
authors.initials: CG
authors.lastname: Singh
authors.affiliation: Senior Resident, Department of General Surgery, Regional Institute of Medical Sciences , Imphal West, Manipur, India .
authors.forename: Sridartha
authors.initials: S
authors.lastname: Khumukcham
authors.affiliation: Junior Resident, Department of General Surgery, Regional Institute of Medical Sciences , Imphal West, Manipur, India .
authors.forename: Raju
authors.initials: R
authors.lastname: Rangaswamy
authors.affiliation: Junior Resident, Department of General Surgery, Regional Institute of Medical Sciences , Imphal West, Manipur, India .
authors.forename: Yibenthung S
authors.initials: YS
authors.lastname: Ezung
authors.affiliation: Junior Resident, Department of General Surgery, Regional Institute of Medical Sciences , Imphal West, Manipur, India .
authors.forename: Sowdin Reddy
authors.initials: SR
authors.lastname: Chittvolu
authors.affiliation: Professor, Department of Department of Immunohaematology and Blood Transfusion, Regional Institute of Medical Sciences , Imphal West, Manipur, India .
authors.forename: A Barindra
authors.initials: AB
authors.lastname: Sharma
authors.affiliation: Professor, Department of General Surgery, Regional Institute of Medical Sciences , Imphal West, Manipur, India .
authors.forename: H Manihar
authors.initials: HM
authors.lastname: Singh
keywords: Acute inflammatory mediators; Appendiceal perforation; Negative appendectomy