title: In vitro cholinesterase inhibitory activity of some plants used in Iranian traditional medicine.
abstract: In this study, in vitro evaluation of cholinesterase inhibitory (ChEI) activity of various plants including betel nuts (Areca catechu L.), clove buds (Syzygium aromaticum L.), aerial parts of dodder (Cuscuta chinensis Lam.), common polypody rhizomes (Polypodium vulgare L.) and turpeth roots (Ipomoea turpethum R. Br.) which were recommended for the treatment of AD symptoms in Iranian Traditional Medicine (ITM) is reported. Among them, aqueous extract of A. catechu L. was found as the most potent anti-AChE (IC50= 32.00 μg/mL) and anti-BChE (IC50= 48.81 ± 0.1200 μg/mL) agent.
authors.affiliation: a Faculty of Pharmacy, Medicinal Plants Research Center , Tehran University of Medical Sciences , Tehran , Iran.|b Persian Medicine and Pharmacy Research Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Saeedi
authors.affiliation: c Faculty of Pharmacy, Department of Pharmacognosy , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Khatereh
authors.initials: K
authors.lastname: Babaie
authors.affiliation: b Persian Medicine and Pharmacy Research Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Elahe
authors.initials: E
authors.lastname: Karimpour-Razkenari
authors.affiliation: c Faculty of Pharmacy, Department of Pharmacognosy , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Vazirian
authors.affiliation: b Persian Medicine and Pharmacy Research Center , Tehran University of Medical Sciences , Tehran , Iran.|d Faculty of Pharmacy, Department of Medicinal Chemistry , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Tahmineh
authors.initials: T
authors.lastname: Akbarzadeh
authors.affiliation: b Persian Medicine and Pharmacy Research Center , Tehran University of Medical Sciences , Tehran , Iran.|c Faculty of Pharmacy, Department of Pharmacognosy , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Khanavi
authors.affiliation: b Persian Medicine and Pharmacy Research Center , Tehran University of Medical Sciences , Tehran , Iran.|e Faculty of Pharmacy, Department of Drug and Food Control , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mannan
authors.initials: M
authors.lastname: Hajimahmoodi
authors.affiliation: b Persian Medicine and Pharmacy Research Center , Tehran University of Medical Sciences , Tehran , Iran.|c Faculty of Pharmacy, Department of Pharmacognosy , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Shams Ardekani
mesh_terms: D001114:Areca / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D002802:Cholinesterases; D034182:Cuscuta / Q000737:chemistry; D020128:Inhibitory Concentration 50; D027741:Ipomoea / Q000737:chemistry; D007492:Iran; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D032494:Polypodium / Q000737:chemistry; D027842:Syzygium / Q000737:chemistry
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D002802:Cholinesterases
keywords: A. catechu; C. chinensis; Cholinesterase inhibitors; I. turpethum; Iranian traditional medicine; P. vulgare; S. aromaticum