title: Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis.
abstract: Several studies have investigated the relationship between serum Se concentration and cervical cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum selenium levels and cervical cancer. Twelve studies investigating the association by univariate analysis and five studies by multivariate analysis were identified after a systematic search of PubMed, Wanfang, CNKI, and SinoMed databases. Standard mean differences (SMD) or odds ratios (OR) with the corresponding 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups. In univariate analysis, serum selenium levels in cervical cancer cases were significantly lower than in controls (SMD = -4.86, 95% CI -6.03-3.69). Subgroup analysis showed consistent results. In multivariate analysis, serum selenium levels in cervical cancer cases were also significantly lower than in controls (OR = 0.55, 95% CI 0.42-0.73). After treatment, the serum selenium levels increased significantly (SMD = 2.59, 95% CI 0.50-4.69). In conclusion, high serum selenium levels were associated with cervical cancer, and selenium exposure might be a protective factor for cervical cancer.
authors.affiliation: Department of Oncology, The Central Hospital of Enshi Autonomous of Prefecture, Enshi Clinical College of Wuhan University, Enshi, 445000, China.|Enshi Clinical College of Wuhan University, Enshi, China.
authors.forename: Du
authors.initials: D
authors.lastname: He
authors.affiliation: Department of Oncology, The Central Hospital of Enshi Autonomous of Prefecture, Enshi Clinical College of Wuhan University, Enshi, 445000, China.|Enshi Clinical College of Wuhan University, Enshi, China.
authors.forename: Zaiping
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Oncology, The Central Hospital of Enshi Autonomous of Prefecture, Enshi Clinical College of Wuhan University, Enshi, 445000, China.|Enshi Clinical College of Wuhan University, Enshi, China.
authors.forename: Chuying
authors.initials: C
authors.lastname: Huang
authors.affiliation: Department of Oncology, The Central Hospital of Enshi Autonomous of Prefecture, Enshi Clinical College of Wuhan University, Enshi, 445000, China.|Enshi Clinical College of Wuhan University, Enshi, China.
authors.forename: Xiping
authors.initials: X
authors.lastname: Fang
authors.affiliation: Department of Oncology, The Central Hospital of Enshi Autonomous of Prefecture, Enshi Clinical College of Wuhan University, Enshi, 445000, China. hdu1234@163.com.|Enshi Clinical College of Wuhan University, Enshi, China. hdu1234@163.com.
authors.forename: Dian
authors.initials: D
authors.lastname: Chen
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015999:Multivariate Analysis; D012643:Selenium / Q000097:blood*; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000628:therapy
chemical_list: D012643:Selenium
keywords: Cervical cancer; Meta-analysis; Selenium; Serum