title: Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA).
abstract: In the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long-term survival for selected patients with PM. Among prognostic indicators after the treatment, completeness of cytoreduction is the most independent predictors of survival. However, peritoneal recurrence is a main cause of recurrence, even after complete cytoreduction. As a cause of peritoneal recurrence, small PM may be overlooked at the time of cytoreductive surgery (CRS), therefore, development of a new method to detect small PM is desired. Recently, photodynamic diagnosis (PDD) was developed for detection of PM. The objectives of this review were to evaluate whether PDD using 5-aminolevulinic acid (ALA) could improve detection of small PM.
authors.affiliation: NPO Organization to support Peritoneal Surface Malignancy Treatment, 510 Fukushima-Cho, Shimogyou-Ku, Kyoto 600-8189, Japan. haruaki.ishibashi@tokushukai.jp.|Peritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, Japan. haruaki.ishibashi@tokushukai.jp.|Department of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, Japan. haruaki.ishibashi@tokushukai.jp.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yonemura
authors.affiliation: Central Research Resource Center, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. yendo2@staff.kanazawa-u.ac.jp.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Endo
authors.affiliation: NPO HIPEC Istanbul, Guzelbahce Sokak No:15 Nisantasi, Istanbul 34367, Turkey. drecanbay@gmail.com.
authors.forename: Emel
authors.initials: E
authors.lastname: Canbay
authors.affiliation: Peritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, Japan. LYMIKELEO@hotmail.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: NPO Organization to support Peritoneal Surface Malignancy Treatment, 510 Fukushima-Cho, Shimogyou-Ku, Kyoto 600-8189, Japan.
authors.forename: Haruaki
authors.initials: H
authors.lastname: Ishibashi
authors.affiliation: Department of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, Japan. mizumotoakiyoshi1206@yahoo.co.jp.
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Mizumoto
authors.affiliation: Department of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, Japan. hirano@kusatsu-gh.or.jp.
authors.forename: Masamitu
authors.initials: M
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authors.affiliation: Department of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, Japan. omokage.0117@gmail.com.
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authors.initials: Y
authors.lastname: Imazato
authors.affiliation: Department of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, Japan. s380402@yahoo.co.jp.
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authors.affiliation: Department of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, Japan. michi@yd6.so-net.ne.jp.
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authors.initials: M
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authors.affiliation: Department of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, Japan. nogupinbad@yahoo.co.jp.
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authors.affiliation: Department of Peritoneal Surface Oncology, Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, China. liyansd2@163.com.
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authors.lastname: Li
authors.affiliation: Peritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, Japan. akebono_jaguar@yahoo.co.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Wakama
authors.affiliation: Peritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, Japan. iceman0710@hotmail.co.jp.
authors.forename: Kazuhiro
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authors.affiliation: Peritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, Japan. ko-ta-music@kzd.biglobe.ne.jp.
authors.forename: Koutarou
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authors.affiliation: Peritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, Japan. hiroshihiroshi.s@gmail.com.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shintani
authors.affiliation: Peritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, Japan. tennis.ce.surge@gmail.com.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshitake
authors.affiliation: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsu-Cho, Midori-ku, Yokohama 226-8501, Japan. sogura@bio.titech.ac.jp.
authors.forename: Shun-Ichiro
authors.initials: SI
authors.lastname: Ogura
keywords: ABCG2; PEPT1; aminolevulinic acid; ferrochelatase; peritoneal surface malignancies; photodynamic diagnosis (PDD)