title: Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis.
abstract: Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345C, 2800, Kgs. Lyngby, Denmark.
authors.forename: Maksymilian
authors.initials: M
authors.lastname: Kurek
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345C, 2800, Kgs. Lyngby, Denmark.
authors.forename: Matthias
authors.initials: M
authors.lastname: Carnoy
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345C, 2800, Kgs. Lyngby, Denmark.
authors.forename: Peter E
authors.initials: PE
authors.lastname: Larsen
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345C, 2800, Kgs. Lyngby, Denmark.
authors.forename: Line H
authors.initials: LH
authors.lastname: Nielsen
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345C, 2800, Kgs. Lyngby, Denmark.
authors.forename: Ole
authors.initials: O
authors.lastname: Hansen
authors.affiliation: Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Rades
authors.affiliation: Institute of Sensor and Actuator Systems, TU Wien, Gusshausstrasse 27-29, 1040, Vienna, Austria.
authors.forename: Silvan
authors.initials: S
authors.lastname: Schmid
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345C, 2800, Kgs. Lyngby, Denmark.
authors.forename: Anja
authors.initials: A
authors.lastname: Boisen
mesh_terms: D036103:Nanotechnology; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013055:Spectrophotometry, Infrared; D014732:Vibration
chemical_list: D004364:Pharmaceutical Preparations
keywords: IR spectroscopy; crystallization; nanomechanics; nanoparticles