title: Association of serum 25-hydroxyvitamin D3with adipokines and inflammatory marker in persons with prediabetes mellitus.
abstract: BACKGROUND
  The association of vitamin D status and inflammation prediabetes mellitus (PreDM) individuals has not been investigated. We investigated the association of serum 25-hydroxyvitamin D3(25(OH) D3) with adipokines and inflammatory markers in persons with PreDM.
  
  
  METHODS
  In this cross-sectional study, we stratified 418 nondiabetic subjects as having PreDM or normal fasting glucose (NFG), and divided PreDM or NFG subjects into vitamin D sufficient, vitamin D insufficient and vitamin D deficient subgroups. 25(OH) D3concentrations were determined by HPLC. Serum tumor necrosis factor-α (TNF-α), interleiukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP), adiponectin, leptin and resistin were measured by ELISA.
  
  
  RESULTS
  In the PreDM group, compared with those in the vitamin D sufficient subgroup, vitamin D insufficient subgroup and vitamin D deficient subgroup had higher concentrations of hs-CRP and leptin (P<0.05). In the PreDM-deficient or PreDM-insufficient subgroup, mean hs-CRP and leptin concentration was higher than in the PreDM-sufficient, NFG-deficient, NFG-insufficient and NFG-sufficient subgroups (P<0.05). Serum 25(OH) D3concentrations were inversely associated with hs-CRP and leptin concentrations after adjusted the BMI only in the PreDM group (P<0.05). At the multivariate analysis, hs-CRP and leptin were the major determinant of 25(OH) D3concentration (β=-0.174 and β=-0.171, respectively).
  
  
  CONCLUSIONS
  25(OH) D3status in PreDM individuals was inversely correlated with concentrations of hs-CRP and leptin, suggesting their involvement in the inflammation response between vitamin D status and PreDM.
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, PR China.
authors.forename: Meilin
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, General Hospital of Tianjin Medical University, Tianjin, PR China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Clinical Laboratory, Tianjin Chest Hospital, Tianjin, PR China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Tian
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, PR China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Health Education and Guidance Center of Heping District, Tianjin, PR China.
authors.forename: Weiqiao
authors.initials: W
authors.lastname: Liu
authors.affiliation: Health Education and Guidance Center of Heping District, Tianjin, PR China.
authors.forename: Yuwen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, PR China. Electronic address: huangguowei@tmu.edu.cn.
authors.forename: Guowei
authors.initials: G
authors.lastname: Huang
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002112:Calcifediol / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood*; D055815:Young Adult
chemical_list: D054392:Adipokines; D015415:Biomarkers; D002112:Calcifediol
keywords: 25-Hydroxyvitamin D(3); Adipokines; Inflammation; Prediabetes mellitus