title: [An effect of ipidacrine (neuromidin) on electroneuromyographic parameters in the conditions of artificial decompression (a clinical/instrumental study)].
abstract: OBJECTIVE
  To study an effect of neuromidin on the changes in electroneuromyographic (ENMG) parameters in patients with carpal tunnel syndrome in the conditions of artificial decompression of a forearm.
  
  
  METHODS
  Sixty-four 64 patients, 46 women and 18 men, mean age 50,7±4,5years, matched for disease severity were studied. The patients were randomized into neuromidin group and control group. Neuromidin was introduced using subcutaneous local perineural injections. Characteristics of neuromidin effect on the changes in ENMG parameters of the median nerve were studied in a model of additional artificial decompression of the median nerve.
  
  
  CONCLUSIONS
  There was the significant depression of the nerve function and worsening of ENMG parameters during the additional decompression as well as the aggravation of conduction block along nerve fibers (motor and sensory). In patients treated with ipidacrine, there was an increase in the amplitude of sensory and (to a less extent) of M-response that indicated the activation of axonal transport and reservation of functioning of the compressed nerve.
authors.affiliation: Ekaterinburg Medical Research Center for Profilaxis and Health Protection of Industrial Wokers, Ekaterinburg.
authors.forename: E V
authors.initials: EV
authors.lastname: Bahtereva
authors.affiliation: Ekaterinburg Medical Research Center for Profilaxis and Health Protection of Industrial Wokers, Ekaterinburg.
authors.forename: V A
authors.initials: VA
authors.lastname: Shirokov
authors.affiliation: Ekaterinburg Medical Research Center for Profilaxis and Health Protection of Industrial Wokers, Ekaterinburg.
authors.forename: E L
authors.initials: EL
authors.lastname: Leiderman
authors.affiliation: Ekaterinburg Medical Research Center for Profilaxis and Health Protection of Industrial Wokers, Ekaterinburg.
authors.forename: N L
authors.initials: NL
authors.lastname: Terechov
authors.affiliation: Institute of Industrial Ecology Russia Acdemy of Sciences, Ekaterinburg, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Varaksin
authors.affiliation: Institute of Industrial Ecology Russia Acdemy of Sciences, Ekaterinburg, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Panov
mesh_terms: D000328:Adult; D000634:Aminoquinolines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002349:Carpal Tunnel Syndrome / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D019299:Decompression, Surgical; D004576:Electromyography / Q000187:drug effects*; D005260:Female; D005542:Forearm; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000187:drug effects* / Q000503:physiopathology; D008875:Middle Aged; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology; D009431:Neural Conduction / Q000187:drug effects*
chemical_list: D000634:Aminoquinolines; C049860:amiridine