title: Association of body mass index (BMI) and percent body fat among BMI-defined non-obese middle-aged individuals: Insights from a population-based Canadian sample.
abstract: To evaluate the association between percent body fat (%BF) and body mass index (BMI) among BMI-defined non-obese individuals between 40 and 69 years of age using a population-based Canadian sample.
  
  
  
  Cross-sectional data from the Canadian Health Measures Survey (2007 and 2009) was used to select all middle-aged individuals with BMI &lt; 30 kg/m2 (n = 2,656). %BF was determined from anthropometric skinfolds and categorized according to sex-specific equations. Association of other anthropometry measures and metabolic markers were evaluated across different %BF categories. Significance of proportions was evaluated using chi-squared and Bonferroni-adjusted Wald test. Diagnostic performance measures of BMI-defined overweight categories compared to those defined by %BF were reported.
  
  
  
  The majority (69%) of the sample was %BF-defined overweight/obese, while 55% were BMI-defined overweight. BMI category was not concordant with %BF classification for 30% of the population. The greatest discordance between %BF and BMI was observed among %BF-defined overweight/obese women (32%). Sensitivity and specificity of BMI-defined overweight compared to %BF-defined overweight/obese were (58%, 94%) among females and (82%, 59%) among males respectively. According to the estimated negative predictive value, if an individual is categorized as BMI-defined non-obese, he/she has a 52% chance of being in the %BF-defined overweight/obese category.
  
  
  
  Middle-aged individuals classified as normal by BMI may be overweight/obese based on measures of %BF. These individuals may be at risk for chronic diseases, but would not be identified as such based on their BMI classification. Quantifying %BF in this group could inform targeted strategies for disease prevention.
authors.affiliation: Human Performance Laboratory, University of Calgary, Calgary, AB. khmcolli@ucalgary.ca.
authors.forename: Kelsey H
authors.initials: KH
authors.lastname: Collins
authors.forename: Behnam
authors.initials: B
authors.lastname: Sharif
authors.forename: Claudia
authors.initials: C
authors.lastname: Sanmartin
authors.forename: Raylene A
authors.initials: RA
authors.lastname: Reimer
authors.forename: Walter
authors.initials: W
authors.lastname: Herzog
authors.forename: Rick
authors.initials: R
authors.lastname: Chin
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Marshall
mesh_terms: D000328:Adult; D000368:Aged; D001823:Body Composition; D015992:Body Mass Index; D002170:Canada; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis*; D050177:Overweight / Q000175:diagnosis*; D012680:Sensitivity and Specificity