title: Silver-Catalyzed Cyclization of ortho-Carbonylarylacetylenols for the Synthesis of Dihydronaphthofurans.
abstract: ortho-Carbonylarylacetylenols have been employed for the synthesis of dihydronaphthofurans via AgTFA-catalyzed annulation reaction. A broad range of substrates both ortho-keto- and ortho-formylarylacetylenols could be employed in this transformation providing the desired products in good yields. However, the reaction pathways of these two substrates are different. The reaction of the ketone precursors could directly lead to the desired products in a single operation while the reaction of the aldehyde precursors required a one-pot two-step approach, without isolation of the bicyclic acetal intermediates. In addition, this method was also successfully used for the synthesis of dihydronaphthopyrans in very good yields.
authors.affiliation: Program on Chemical Biology, Chulabhorn Graduate Institute , Center of Excellence on Environmental Health and Toxicology (EHT), Ministry of Education, 54 Kamphaeng Phet 6, Laksi, Bangkok 10210, Thailand.
authors.forename: Bhornrawin
authors.initials: B
authors.lastname: Akkachairin
authors.affiliation: Program on Chemical Biology, Chulabhorn Graduate Institute , Center of Excellence on Environmental Health and Toxicology (EHT), Ministry of Education, 54 Kamphaeng Phet 6, Laksi, Bangkok 10210, Thailand.|Laboratory of Medicinal Chemistry, Chulabhorn Research Institute , 54 Kamphaeng Phet 6, Laksi, Bangkok 10210, Thailand.
authors.forename: Jumreang
authors.identifier: 0000-0002-1662-151X
authors.initials: J
authors.lastname: Tummatorn
authors.affiliation: Program on Chemical Biology, Chulabhorn Graduate Institute , Center of Excellence on Environmental Health and Toxicology (EHT), Ministry of Education, 54 Kamphaeng Phet 6, Laksi, Bangkok 10210, Thailand.
authors.forename: Nantamon
authors.initials: N
authors.lastname: Supantanapong
authors.affiliation: Program on Chemical Biology, Chulabhorn Graduate Institute , Center of Excellence on Environmental Health and Toxicology (EHT), Ministry of Education, 54 Kamphaeng Phet 6, Laksi, Bangkok 10210, Thailand.
authors.forename: Phongprapan
authors.initials: P
authors.lastname: Nimnual
authors.affiliation: Program on Chemical Biology, Chulabhorn Graduate Institute , Center of Excellence on Environmental Health and Toxicology (EHT), Ministry of Education, 54 Kamphaeng Phet 6, Laksi, Bangkok 10210, Thailand.|Laboratory of Medicinal Chemistry, Chulabhorn Research Institute , 54 Kamphaeng Phet 6, Laksi, Bangkok 10210, Thailand.
authors.forename: Charnsak
authors.initials: C
authors.lastname: Thongsornkleeb
authors.affiliation: Program on Chemical Biology, Chulabhorn Graduate Institute , Center of Excellence on Environmental Health and Toxicology (EHT), Ministry of Education, 54 Kamphaeng Phet 6, Laksi, Bangkok 10210, Thailand.|Laboratory of Medicinal Chemistry, Chulabhorn Research Institute , 54 Kamphaeng Phet 6, Laksi, Bangkok 10210, Thailand.
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat