title: [Expression of chemokine CXCL12 and its receptor (CXCR4 and CXCR7) in different molecular subtypes of human breast carcinoma and the clinical significance].
abstract: OBJECTIVE
  To study the expressions and the clinical significance of chemokine CXCL12 and its receptor CXCR4, CXCR7 in the human breast carcinoma (BC) with different molecular subtypes.  Methods: The mRNA expressions of CXCL12, CXCR4 and CXCR7 in tissues from 80 patients with different molecular subtype of BC were measured by qRT-PCR. The protein expressions of CXCL12, CXCR4 and CXCR7 in paraffin-embedded samples from 160 patients with different molecular subtypes were detected by immunohistochemical staining.  Results: The mRNA expression levels of CXCL12, CXCR4 and CXCR7 in HER-2 positive BC and TNBC tissues were significantly higher than those in luminal A and luminal B subtype BC tissues (all P<0.05), but their expressions were not different between luminal A and luminal B subtype BC tissues or between HER-2 positive BC and TNBC tissues. The positive expression rates of CXCL12 protein in HER-2 positive BC and TNBC tissues were significantly higher than those in luminal A and luminal B subtype BC tissues (all P<0.05), while their expressions were not different between luminal A and luminal B subtype BC tissues or between HER-2 positive BC and TNBC tissues.
  
  
  CONCLUSIONS
  High expressions of the gene CXCL12 and its receptor CXCR4 and CXCR7 in HER-2 positive BC and TNBC may be closely associated with their poor prognosis. Inhibition of their expressions in HER-2 positive BC and TNBC may provide a strategy for treating BC in clinic.
authors.affiliation: Department of Breast and Thyroid Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China wuwei8912006@sina.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Breast and Thyroid Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Liyuan
authors.initials: L
authors.lastname: Qian
authors.affiliation: Department of Breast and Thyroid Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Dai
authors.affiliation: Department of Breast and Thyroid Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Boni
authors.initials: B
authors.lastname: Ding
authors.affiliation: Department of Breast and Thyroid Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Xuedong
authors.initials: X
authors.lastname: Chen
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry* / Q000145:classification; D002277:Carcinoma / Q000737:chemistry; D054377:Chemokine CXCL12 / Q000737:chemistry*; D005260:Female; D006801:Humans; D018719:Erb-b2 Receptor Tyrosine Kinases; D054387:Receptors, CXCR / Q000737:chemistry*; D019718:Receptors, CXCR4 / Q000737:chemistry*; D015398:Signal Transduction; D064726:Triple Negative Breast Neoplasms
chemical_list: D054377:Chemokine CXCL12; D018719:Erb-b2 Receptor Tyrosine Kinases; D054387:Receptors, CXCR; D019718:Receptors, CXCR4; C501896:ACKR3 protein, human; C515255:CXCL12 protein, human; C527276:CXCR4 protein, human; C508053:ERBB2 protein, human