title: Functionality of albumin-derived perfluorocarbon-based artificial oxygen carriers in the Langendorff-heart†.
abstract: The aim of this study was to prove whether albumin-derived perfluorocarbon-based nanoparticles (capsules) can operate as a novel artificial oxygen carrier in a rat Langendorff-heart perfusion model. Hearts perfused with capsules showed increased left ventricular pressure and rate pressure product compared to hearts perfused with pure Krebs-Henseleit (KH)-buffer. The capsules prevented the myocardium from functional fail when in their absence a noxious ischemia was observed. Capsules did not change rheological properties of KH-buffer and could repeatedly reload with oxygen. This albumin-derived perfluorocarbon-based artificial oxygen carrier preserved the function of rat hearts due to the transport of oxygen in a satisfactory manner. Because of these positive results, the functionality of the applied capsules should be verified in living animals.
authors.affiliation: a Institute for Physiological Chemistry, University Hospital Essen, University of Duisburg-Essen , Essen , Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Wrobeln
authors.affiliation: b Institute of Physiology, Justus-Liebig-University , Giessen , Germany.
authors.forename: Klaus D
authors.initials: KD
authors.lastname: Schlüter
authors.affiliation: c Institute for Physical Chemistry, University of Duisburg-Essen, CeNIDE , Essen , Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Linders
authors.affiliation: c Institute for Physical Chemistry, University of Duisburg-Essen, CeNIDE , Essen , Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Zähres
authors.affiliation: c Institute for Physical Chemistry, University of Duisburg-Essen, CeNIDE , Essen , Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Mayer
authors.affiliation: a Institute for Physiological Chemistry, University Hospital Essen, University of Duisburg-Essen , Essen , Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Kirsch
authors.affiliation: a Institute for Physiological Chemistry, University Hospital Essen, University of Duisburg-Essen , Essen , Germany.
authors.forename: Katja B
authors.initials: KB
authors.lastname: Ferenz
mesh_terms: D000418:Albumins / Q000737:chemistry*; D000818:Animals; D001802:Blood Substitutes / Q000737:chemistry* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005466:Fluorocarbons / Q000737:chemistry* / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects; D010100:Oxygen / Q000378:metabolism; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000418:Albumins; D001802:Blood Substitutes; D005466:Fluorocarbons; D010100:Oxygen
keywords: Langendorff-heart; Perfluorocarbon-based artificial oxygen carrier; albumin; blood substitutes; nanocapsules; perfluorodecalin