title: Vitamin D and muscle trophicity.
abstract: OBJECTIVE
  We review recent findings on the involvement of vitamin D in skeletal muscle trophicity.
  
  
  RESULTS
  Vitamin D deficiencies are associated with reduced muscle mass and strength, and its supplementation seems effective to improve these parameters in vitamin D-deficient study participants. Latest investigations have also evidenced that vitamin D is essential in muscle development and repair. In particular, it modulates skeletal muscle cell proliferation and differentiation. However, discrepancies still exist about an enhancement or a decrease of muscle proliferation and differentiation by the vitamin D. Recently, it has been demonstrated that vitamin D influences skeletal muscle cell metabolism as it seems to regulate protein synthesis and mitochondrial function. Finally, apart from its genomic and nongenomic effects, recent investigations have demonstrated a genetic contribution of vitamin D to muscle functioning.
  
  
  CONCLUSIONS
  Recent studies support the importance of vitamin D in muscle health, and the impact of its deficiency in regard to muscle mass and function. These 'trophic' properties are of particular importance for some specific populations such as elderly persons and athletes, and in situations of loss of muscle mass or function, particularly in the context of chronic diseases.
authors.affiliation: aUnité de Nutrition Humaine, UMR 1019 INRA UCA, Equipe ASMS, CRNH Auvergne bUniversité Clermont Auvergne cService de Nutrition Clinique, CHU Clermont-Ferrand, France.
authors.forename: Carla
authors.initials: C
authors.lastname: Domingues-Faria
authors.forename: Yves
authors.initials: Y
authors.lastname: Boirie
authors.forename: Stéphane
authors.initials: S
authors.lastname: Walrand
mesh_terms: D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D019587:Dietary Supplements; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism*; D009135:Muscular Diseases / Q000209:etiology / Q000378:metabolism*; D014807:Vitamin D / Q000378:metabolism* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications / Q000378:metabolism*; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D014815:Vitamins; D014807:Vitamin D