title: Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy.
abstract: Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine influenced by single nucleotide polymorphisms (SNP) located in upstream regulatory regions. Here we address the effects of five SNP (rs1518111, rs3021094, rs3024491, rs1800872 and rs1800871) on CD4 T-cell counts in Indonesian HIV patients assessed before ART and over 12months on treatment. Heterozygosity at rs1518111 or rs1800872 associated with low CD4 T-cell counts at all time points. Both alleles were carried in two haplotypes. Haplotype 21122 (present in 30% of participants) associated with low CD4 T-cell counts, whereas 21222 (in 6% of participants) did not. Hence untyped SNP(s) tagged by 21122 may depress CD4 T-cell counts. The association with heterozygosity suggests synergy with an allele from a haplotype lacking rs1518111 and/or rs1800872.
authors.affiliation: School of Biomedical Science, Curtin University, Perth, Western Australia, Australia.
authors.forename: Deane Maria
authors.initials: DM
authors.lastname: Dmello
authors.affiliation: Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
authors.forename: Ibnu
authors.initials: I
authors.lastname: Ariyanto
authors.affiliation: Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
authors.forename: Riwanti
authors.initials: R
authors.lastname: Estiasari
authors.affiliation: School of Biomedical Science, Curtin University, Perth, Western Australia, Australia.
authors.forename: Samuel
authors.initials: S
authors.lastname: Halstrom
authors.affiliation: School of Biomedical Science, Curtin University, Perth, Western Australia, Australia.
authors.forename: Jessica
authors.initials: J
authors.lastname: Gaff
authors.affiliation: School of Biomedical Science, Curtin University, Perth, Western Australia, Australia.
authors.forename: Silvia
authors.initials: S
authors.lastname: Lee
authors.affiliation: School of Biomedical Science, Curtin University, Perth, Western Australia, Australia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. Electronic address: patricia.price@curtin.edu.au.
authors.forename: Patricia
authors.initials: P
authors.lastname: Price
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D005838:Genotype; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D007214:Indonesia; D016753:Interleukin-10 / Q000235:genetics*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents; D016753:Interleukin-10
keywords: Antiretroviral therapy; CD4 T-cell counts; HIV; IL-10; Indonesia; Single nucleotide polymorphism