title: Posterior Reversible Encephalopathy Syndrome With Spinal Cord Involvement in Children.
abstract: We characterized a cohort of patients with posterior reversible encephalopathy syndrome with spinal cord involvement. We encountered 2 children and identified an additional 19 patients from the internet databases. Of the 21 patients analyzed, 8 were children. The mean peak systolic blood pressure in adults was significantly higher than in children (221.8 ± 14.3 vs 191.4 ± 31.3 mm Hg; P < .01). Regardless of age, the most common clinical symptom was headache (90%) and the least common clinical symptom was seizures (28%). Atypical neuroimaging was more common in children (63%) than in adults (8%). Abnormal cerebrospinal fluid results were frequently found in children (83%). All children recovered uneventfully, but 3 adults had sequelae. A broader clinicoradiologic spectrum makes the diagnosis of children more complex than in adults. Awareness of the atypical features with a meticulous management of hypertension is imperative to avoid unnecessary invasive workups and to achieve an uneventful recovery.
authors.affiliation: 1 Division of Pediatric Neurology, Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Tai-Heng
authors.initials: TH
authors.lastname: Chen
authors.affiliation: 2 Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Wei-Chen
authors.initials: WC
authors.lastname: Lin
authors.affiliation: 3 Division of Pediatric Emergency, Department of Emergency, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Wei-Tsun
authors.initials: WT
authors.lastname: Kao
authors.affiliation: 3 Division of Pediatric Emergency, Department of Emergency, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Chien-Ming
authors.initials: CM
authors.lastname: Tseng
authors.affiliation: 3 Division of Pediatric Emergency, Department of Emergency, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Yong-Hao
authors.initials: YH
authors.lastname: Tseng
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001794:Blood Pressure; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D005260:Female; D006261:Headache / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging; D054038:Posterior Leukoencephalopathy Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012189:Retrospective Studies; D012640:Seizures / Q000000981:diagnostic imaging / Q000503:physiopathology; D013116:Spinal Cord / Q000000981:diagnostic imaging; D013118:Spinal Cord Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D015415:Biomarkers
keywords: atypical manifestations; cerebrovascular disorders; childhood; posterior reversible encephalopathy syndrome with spinal cord involvement