title: Lobar lung transplantation from deceased donors: A systematic review.
abstract: OBJECTIVE
  To systematically review reports on deceased-donor-lobar lung transplantation (ddLLTx) and uniformly describe size matching using the donor-to-recipient predicted-total lung-capacity (pTLC) ratio.
  
  
  METHODS
  We set out to systematically review reports on ddLLTx and uniformly describe size matching using the donor-to-recipient pTLC ratio and to summarize reported one-year survival data of ddLLTx and conventional-LTx. We searched in PubMed, CINAHLviaEBSCO, Cochrane Database of Systematic ReviewsviaWiley (CDSR), Database of Abstracts of Reviews of EffectsviaWiley (DARE), Cochrane Central Register of Controlled TrialsviaWiley (CENTRAL), Scopus (which includes EMBASE abstracts), and Web of Science for original reports on ddLLTx.
  
  
  RESULTS
  Nine observational cohort studies reporting on 301 ddLLTx met our inclusion criteria for systematic review of size matching, and eight for describing one-year-survival. The ddLLTx-group was often characterized by high acuity; however there was heterogeneity in transplant indications and pre-operative characteristics between studies. Data to calculate the pTLC ratio was available for 242 ddLLTx (80%). The mean pTLCratio before lobar resection was 1.25 ± 0.3 and the transplanted pTLCratio after lobar resection was 0.76 ± 0.2. One-year survival in the ddLLTx-group ranged from 50%-100%, compared to 72%-88% in the conventional-LTx group. In the largest study ddLLTx (n= 138) was associated with a lower one-year-survival compared to conventional-LTx (n= 539) (65.1%vs84.1%,P< 0.001).
  
  
  CONCLUSIONS
  Further investigations of optimal donor-to-recipient size matching parameters for ddLLTx could improve outcomes of this important surgical option.
authors.affiliation: Michael Eberlein, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Eberlein
authors.affiliation: Michael Eberlein, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Reed
authors.affiliation: Michael Eberlein, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.
authors.forename: Mayy
authors.initials: M
authors.lastname: Chahla
authors.affiliation: Michael Eberlein, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.
authors.forename: Servet
authors.initials: S
authors.lastname: Bolukbas
authors.affiliation: Michael Eberlein, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.
authors.forename: Amy
authors.initials: A
authors.lastname: Blevins
authors.affiliation: Michael Eberlein, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.
authors.forename: Dirk
authors.initials: D
authors.lastname: Van Raemdonck
authors.affiliation: Michael Eberlein, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.
authors.forename: Alessia
authors.initials: A
authors.lastname: Stanzi
authors.affiliation: Michael Eberlein, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Inci
authors.affiliation: Michael Eberlein, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.
authors.forename: Silvana
authors.initials: S
authors.lastname: Marasco
authors.affiliation: Michael Eberlein, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Shigemura
authors.affiliation: Michael Eberlein, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.
authors.forename: Clemens
authors.initials: C
authors.lastname: Aigner
authors.affiliation: Michael Eberlein, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.
authors.forename: Tobias
authors.initials: T
authors.lastname: Deuse
keywords: Cadaveric lobar lung transplantation; Lobar lung transplantation from deceased donors; Lung size matching; Primary graft dysfunction; Survival