title: Nickel-Catalyzed Synthesis of Quinazolinediones.
abstract: A nickel(0)-catalyzed method for the synthesis of quinazolinediones from isatoic anhydrides and isocyanates is described. High-throughput ligand screening revealed that XANTPHOS was the optimal ligand for this transformation. Subsequent optimization studies, supported by kinetic analysis, significantly expanded the reaction scope. The reaction exhibits a case of substrate inhibition kinetics with respect to the isocyanate. Preliminary results on an asymmetric synthesis of atropisomeric quinazolinediones are reported.
authors.affiliation: Chemical and Synthetic Development, Bristol-Myers Squibb Company , One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States.
authors.forename: Gregory L
authors.identifier: 0000-0001-8779-1404
authors.initials: GL
authors.lastname: Beutner
authors.affiliation: Chemical and Synthetic Development, Bristol-Myers Squibb Company , One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States.
authors.forename: Yi
authors.initials: Y
authors.lastname: Hsiao
authors.affiliation: Chemical and Synthetic Development, Bristol-Myers Squibb Company , One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States.
authors.forename: Thomas
authors.initials: T
authors.lastname: Razler
authors.affiliation: Chemical and Synthetic Development, Bristol-Myers Squibb Company , One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Simmons
authors.affiliation: Chemical and Synthetic Development, Bristol-Myers Squibb Company , One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States.
authors.forename: William
authors.initials: W
authors.lastname: Wertjes