title: Unified reduction principle for the evolution of mutation, migration, and recombination.
abstract: Modifier-gene models for the evolution of genetic information transmission between generations of organisms exhibit the reduction principle: Selection favors reduction in the rate of variation production in populations near equilibrium under a balance of constant viability selection and variation production. Whereas this outcome has been proven for a variety of genetic models, it has not been proven in general for multiallelic genetic models of mutation, migration, and recombination modification with arbitrary linkage between the modifier and major genes under viability selection. We show that the reduction principle holds for all of these cases by developing a unifying mathematical framework that characterizes all of these evolutionary models.
authors.affiliation: Information and Computer Sciences, University of Hawaii at Mānoa, Honolulu, HI 96822.|Konrad Lorenz Institute for Evolution and Cognition Research, Klosterneuburg, Austria A3400.
authors.forename: Lee
authors.initials: L
authors.lastname: Altenberg
authors.affiliation: School of Mathematical Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Uri
authors.initials: U
authors.lastname: Liberman
authors.affiliation: Department of Biology, Stanford University, Stanford, CA 94305-5020 mfeldman@stanford.edu.
authors.forename: Marcus W
authors.initials: MW
authors.lastname: Feldman
mesh_terms: D000483:Alleles; D019143:Evolution, Molecular; D005828:Genetics, Population; D008957:Models, Genetic; D009154:Mutation; D011995:Recombination, Genetic; D012641:Selection, Genetic
keywords: dispersal; external stability; modifier genes; mutation; recombination