title: Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1.
abstract: Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA (lncRNA), was the earliest discovered to be correlated with cancer and contributes to the initiation and development of several types of tumors. Dysregulation of MALAT1 expression is frequently observed in many types of cancer such as gastric cancer, esophageal squamous cell carcinoma and glioma. To date, the role of MALAT1 and the underlying mechanisms in tongue cancer development remain unclear. In the present study, we studied the influence of MALAT1 on tongue cancer cell lines and clinical tongue cancer samples so as to detect its function and the underlying mechanism. In the present study, lncRNA-MALAT1 was specifically upregulated in tongue cancer cell lines and overexpression promoted tongue cancer cell growth by targeting miR-124. Knockdown of MALAT1 suppressed the growth and invasion of human tongue cancer cells and inhibited metastasis in vitro and in vivo. In addition, miR-124-dependent jagged1 (JAG1) regulation was required for MALAT1-induced tongue cancer cell growth. Our data revealed that MALAT1 inhibited tongue cancer cell growth and metastasis through miR-124-dependent JAG1 regulation. In conclusion, we revealed that MALAT1 may play an oncogenic role by increasing proliferation and metastasis of tongue cancer and is a potential therapeutic target in human tongue cancer.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Affiliated Zhongshan Hospital, Sun Yat-sen University, Zhongshan, Guangdong 528403, P.R. China.
authors.forename: Tong-Han
authors.initials: TH
authors.lastname: Zhang
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, P.R. China.
authors.forename: Li-Zhong
authors.initials: LZ
authors.lastname: Liang
authors.affiliation: Department of Medical Intensive Care Unit, The Affiliated Zhongshan Hospital, Sun Yat-sen University, Zhongshan, Guangdong 528403, P.R. China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Liu
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Affiliated Zhongshan Hospital, Sun Yat-sen University, Zhongshan, Guangdong 528403, P.R. China.
authors.forename: Ji-Nan
authors.initials: JN
authors.lastname: Wu
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Affiliated Zhongshan Hospital, Sun Yat-sen University, Zhongshan, Guangdong 528403, P.R. China.
authors.forename: Kui
authors.initials: K
authors.lastname: Su
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Affiliated Zhongshan Hospital, Sun Yat-sen University, Zhongshan, Guangdong 528403, P.R. China.
authors.forename: Jue-Yao
authors.initials: JY
authors.lastname: Chen
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Affiliated Zhongshan Hospital, Sun Yat-sen University, Zhongshan, Guangdong 528403, P.R. China.
authors.forename: Qiao-Yi
authors.initials: QY
authors.lastname: Zheng
authors.affiliation: Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, P.R. China.
authors.forename: Hong-Zhang
authors.initials: HZ
authors.lastname: Huang
authors.affiliation: Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, P.R. China.
authors.forename: Gui-Qing
authors.initials: GQ
authors.lastname: Liao
mesh_terms: D017209:Apoptosis / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D000072100:Jagged-1 Protein / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D014062:Tongue Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C000606273:JAG1 protein, human; D000072100:Jagged-1 Protein; C557041:MALAT1 long non-coding RNA, human; C509207:MIRN124 microRNA, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding