title: Genomic attributes of extended-spectrum β-lactamase-producing Escherichia coli isolated from patients in Lebanon.
abstract: Extended-spectrum β-lactamase-producing (ESBL) Escherichia coli are a public threat worldwide. This study aimed at analyzing the genomic and functional attributes of nine ESBLs taken from rectal swabs.
  
  
  
  Samples were isolated from patients admitted for gastrointestinal and urological procedures at the University Medical Center-Rizk Hospital (UMCRH) in Lebanon. Illumina paired-end libraries were prepared and sequenced.
  
  
  
  The isolates were distributed into five lineages: ST131, ST648, ST405, ST73 and ST38, and harbored blaOXA-1, blaTEM-1B, blaTEM-1Cand aac(6')Ib-cr. ST131 isolates were carriers of stx2 converting I phage.
  
  
  
  This is the first comprehensive genomic analysis performed on ESBLs in Lebanon.
authors.affiliation: School of Arts & Sciences, Department of Natural Sciences, Lebanese American University, Byblos, Lebanon.
authors.forename: Sima
authors.initials: S
authors.lastname: Tokajian
authors.affiliation: School of Arts & Sciences, Department of Natural Sciences, Lebanese American University, Byblos, Lebanon.
authors.forename: Tamara
authors.initials: T
authors.lastname: Salloum
authors.affiliation: Department of Evolution and Ecology, University of California Davis Genome Center, Davis, CA 95616, USA.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Eisen
authors.affiliation: Department of Evolution and Ecology, University of California Davis Genome Center, Davis, CA 95616, USA.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Jospin
authors.affiliation: School of Medicine, Lebanese American University, Byblos, Lebanon.
authors.forename: Anna
authors.initials: A
authors.lastname: Farra
authors.affiliation: School of Medicine, Lebanese American University, Byblos, Lebanon.
authors.forename: Jacques E
authors.initials: JE
authors.lastname: Mokhbat
authors.affiliation: Department of Evolution and Ecology, University of California Davis Genome Center, Davis, CA 95616, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Coil
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016521:Electrophoresis, Gel, Pulsed-Field; D004926:Escherichia coli / Q000145:classification / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D004927:Escherichia coli Infections / Q000382:microbiology*; D016680:Genome, Bacterial; D023281:Genomics; D006801:Humans; D007861:Lebanon; D008826:Microbial Sensitivity Tests; D010802:Phylogeny; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases
keywords: ESBL; Escherichia coli; Genomic epidemiology; Lebanon