title: Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy.
abstract: We present a two-photon (2P, 800 nm) PDT cyclometalated Iridium(iii) complex (Ir-Es) that targets the intracellular nucleus. The complex is capable of migrating sequentially from the nucleus to mitochondria and inducing dual-damage under light exposure. This study suggests that with minor modification of the terminal moieties of complexes, their final intracellular destinations and PDT efficiency can be significantly impacted.
authors.affiliation: School of Life Science, Anhui University, Hefei 230039, P. R. China. xiaohe.t@ahu.edu.cn and Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230039, P. R. China. yptian@ahu.edu.cn.
authors.forename: Xiaohe
authors.identifier: http://orcid.org/0000-0002-2294-3945
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230039, P. R. China. yptian@ahu.edu.cn.
authors.forename: Yingzhong
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: School of Life Science, Anhui University, Hefei 230039, P. R. China. xiaohe.t@ahu.edu.cn and Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230039, P. R. China. yptian@ahu.edu.cn.
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Zhang
authors.affiliation: College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230039, P. R. China. yptian@ahu.edu.cn.
authors.forename: Jieying
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230039, P. R. China. yptian@ahu.edu.cn.
authors.forename: Hongping
authors.identifier: http://orcid.org/0000-0003-3035-3328
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Chemistry, University College London, London, WC1H 0AJ, UK and Department of Chemical Engineering, University College London, London, WC1H 0AJ, UK.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Guan
authors.affiliation: Department of Chemistry, University College London, London, WC1H 0AJ, UK and Department of Chemical Engineering, University College London, London, WC1H 0AJ, UK.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Battaglia
authors.affiliation: Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230039, P. R. China. yptian@ahu.edu.cn and State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China.
authors.forename: Yupeng
authors.identifier: http://orcid.org/0000-0003-2811-2066
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000528:radiation effects; D002467:Cell Nucleus / Q000378:metabolism*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000494:pharmacology* / Q000528:radiation effects; D004247:DNA / Q000235:genetics; D004249:DNA Damage / Q000187:drug effects; D004705:Endocytosis / Q000187:drug effects; D005260:Female; D056945:Hep G2 Cells; D006801:Humans; D007495:Iridium / Q000737:chemistry* / Q000528:radiation effects; D008807:Mice, Inbred BALB C; D008928:Mitochondria / Q000378:metabolism; D010778:Photochemotherapy; D014466:Ultraviolet Rays
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D007495:Iridium; D004247:DNA