title: Interleukin-2 and Interleukin-8 Gene Polymorphisms and Acquired Aplastic Anemia Risk in a Chinese Population.
abstract: OBJECTIVE
  Cytokines IL-2 and IL-8 both participate in immune regulation. However, the relationship between polymorphisms in these two cytokines and the risk of acquired aplastic anemia (acquired AA) has not been explored.
  
  
  METHODS
  We selected five SNPs including rs11575812, rs2069772 and rs2069762 of IL-2, rs2227306 and rs2227543 of IL-8. SNaPshot genotyping was used to test the genotypes of IL-2 and IL-8 polymorphisms in a population of 101 acquired AA patients and 165 healthy controls.
  
  
  RESULTS
  The rs2069762 G allele appeared to be a protective mutation, but no significant differences were found in other four SNPs. We also found that rs2069762 had an impact on the transcriptional regulation.
  
  
  CONCLUSIONS
  It could be assumed that the rs2069762 polymorphism might reduce the risk of acquired aplastic anemia, while the remaining four SNPs might not contribute to susceptibility to acquired AA in a Chinese population.
authors.forename: Xuejie
authors.initials: X
authors.lastname: Zhang
authors.forename: Shengyun
authors.initials: S
authors.lastname: Lin
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Liucheng
authors.initials: L
authors.lastname: Rong
authors.forename: Guangsheng
authors.initials: G
authors.lastname: He
authors.forename: Hailong
authors.initials: H
authors.lastname: He
authors.forename: Yao
authors.initials: Y
authors.lastname: Xue
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Fang
authors.forename: Yaping
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D000741:Anemia, Aplastic / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D044466:Asian People; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015870:Gene Expression; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics* / Q000276:immunology; D016209:Interleukin-8 / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C508606:CXCL8 protein, human; C508594:IL2 protein, human; D007376:Interleukin-2; D016209:Interleukin-8
keywords: Acquired aplastic anemia; Interleukin-2; Interleukin-8; Polymorphism; Transcription