title: Plakortinic Acids A and B: Cytotoxic Cycloperoxides with a Bicyclo[4.2.0]octene Unit from Sponges of the Genera Plakortis and Xestospongia.
abstract: Plakortinic acids A (2) and B (3), two polyketide endoperoxides with a bicyclo[4.2.0]octene unit, were isolated as minor constituents from the sponge-sponge symbiotic association Plakortis halichondrioides-Xestospongia deweerdtae, along with known epiplakinic acid F (1). The structures of the mixture of two inseparable compounds were determined by spectroscopic analysis. Screening for cytotoxic activity of the mixture against two human tumor cell lines revealed that these compounds are very active at sub-micromolar concentration.
authors.affiliation: Department of Chemistry, University of Puerto Rico , P.O. Box 23346, U.P.R. Station, San Juan 00931-3346, Puerto Rico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Jiménez-Romero
authors.affiliation: Department of Chemistry, University of Puerto Rico , P.O. Box 23346, U.P.R. Station, San Juan 00931-3346, Puerto Rico.
authors.forename: Abimael D
authors.identifier: 0000-0001-7748-0856
authors.initials: AD
authors.lastname: Rodríguez
authors.affiliation: Department of Molecular Medicine, Beckman Research Institute, City of Hope , 1500 East Duarte Road, Duarte, California 91010, United States.
authors.forename: Sangkil
authors.initials: S
authors.lastname: Nam
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D010545:Peroxides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D047229:Plakortis / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism; D047131:Xestospongia / Q000737:chemistry*
chemical_list: D010545:Peroxides; D061065:Polyketides; C433591:epiplakinic acid F