title: Phthalocyanine Doped Metal Oxide Nanoparticles on Multiwalled Carbon Nanotubes Platform for the detection of Dopamine.
abstract: The electrocatalytic properties of metal oxides (MO = Fe3O4, ZnO) nanoparticles doped phthalocyanine (Pc) and functionalized MWCNTs, decorated on glassy carbon electrode (GCE) was investigated. Successful synthesis of the metal oxide nanoparticles and the MO/Pc/MWCNT composite were confirmed using UV-Vis, EDX, XRD and TEM techniques. Successful modification of GCE with the MO and their composite was also confirmed using cyclic voltammetry (CV) technique. GCE-MWCNT/ZnO/29H,31H-Pc was the best electrode towards DA detection with very low detection limit (0.75 μM) which compared favourably with literature, good sensitivity (1.45 μA/μM), resistance to electrode fouling, and excellent ability to detect DA without interference from AA signal. Electrocatalytic oxidation of DA on GCE-MWCNT/ZnO/29H,31H-Pc electrode was diffusion controlled but characterized with some adsorption of electro-oxidation reaction intermediates products. The fabricated sensors are easy to prepare, cost effective and can be applied for real sample analysis of dopamine in drug composition. The good electrocatalytic properties of 29H,31H-Pc and 2,3-Nc were related to their (quantum chemically derived) frontier molecular orbital energies and global electronegativities. The better performance of 29H,31H-Pc than 2,3-Nc in aiding electrochemical oxidation of DA might be due to its better electron accepting ability, which is inferred from its lower ELUMOand higher χ.
authors.affiliation: Department of Chemistry, School of Mathematical and Physical Sciences, Faculty of Agriculture, Science and Technology, North-West University (Mafikeng Campus), Private Bag X2046, Mmabatho 2735, South Africa.|Material Science Innovation &Modelling (MaSIM) Focus Area, Faculty of Agriculture, Science and Technology, North-West University (Mafikeng Campus), Private Bag X2046, Mmabatho 2735, South Africa.
authors.forename: Ntsoaki G
authors.initials: NG
authors.lastname: Mphuthi
authors.affiliation: Department of Chemistry, School of Mathematical and Physical Sciences, Faculty of Agriculture, Science and Technology, North-West University (Mafikeng Campus), Private Bag X2046, Mmabatho 2735, South Africa.|Material Science Innovation &Modelling (MaSIM) Focus Area, Faculty of Agriculture, Science and Technology, North-West University (Mafikeng Campus), Private Bag X2046, Mmabatho 2735, South Africa.|Department of Chemistry, Faculty of Science, Obafemi Awolowo University, 220005 Ile-Ife, Nigeria.
authors.forename: Abolanle S
authors.initials: AS
authors.lastname: Adekunle
authors.affiliation: Department of Chemistry, School of Mathematical and Physical Sciences, Faculty of Agriculture, Science and Technology, North-West University (Mafikeng Campus), Private Bag X2046, Mmabatho 2735, South Africa.|Material Science Innovation &Modelling (MaSIM) Focus Area, Faculty of Agriculture, Science and Technology, North-West University (Mafikeng Campus), Private Bag X2046, Mmabatho 2735, South Africa.
authors.forename: Omolola E
authors.initials: OE
authors.lastname: Fayemi
authors.affiliation: Department of Chemistry, School of Mathematical and Physical Sciences, Faculty of Agriculture, Science and Technology, North-West University (Mafikeng Campus), Private Bag X2046, Mmabatho 2735, South Africa.|Material Science Innovation &Modelling (MaSIM) Focus Area, Faculty of Agriculture, Science and Technology, North-West University (Mafikeng Campus), Private Bag X2046, Mmabatho 2735, South Africa.|Department of Chemistry, Faculty of Science, Obafemi Awolowo University, 220005 Ile-Ife, Nigeria.
authors.forename: Lukman O
authors.initials: LO
authors.lastname: Olasunkanmi
authors.affiliation: Department of Chemistry, School of Mathematical and Physical Sciences, Faculty of Agriculture, Science and Technology, North-West University (Mafikeng Campus), Private Bag X2046, Mmabatho 2735, South Africa.|Material Science Innovation &Modelling (MaSIM) Focus Area, Faculty of Agriculture, Science and Technology, North-West University (Mafikeng Campus), Private Bag X2046, Mmabatho 2735, South Africa.
authors.forename: Eno E
authors.initials: EE
authors.lastname: Ebenso
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods*; D015259:Dopamine Agents / Q000032:analysis*; D007211:Indoles / Q000378:metabolism*; D054833:Isoindoles; D053768:Metal Nanoparticles; D037742:Nanotubes, Carbon; D012680:Sensitivity and Specificity
chemical_list: D015259:Dopamine Agents; D007211:Indoles; D054833:Isoindoles; D037742:Nanotubes, Carbon; C013647:phthalocyanine