title: Synthesis and cytotoxicity of oleanolic acid trisaccharide saponins.
abstract: An array of oleanolic acid-type saponins based on β-hederin has been synthesized in a linear or one-pot manner. The cell viability assays indicate that synthetic saponins show antiproliferation activities in three cancer cell lines with IC50values of 2.4-15.1 μM and hederacolchiside A1being the most potent. The results demonstrate that the type of terminal monosaccharides and linkage position have apparent effects on cytotoxicities and selectivities of these saponins against cancer cell lines tested. This study is helpful for future development of more potent anticancer leads.
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China; Key Lab of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Wang
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China; Department of the VIP Internal Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Zengshang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Su
authors.affiliation: Department of the VIP Internal Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of the VIP Internal Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China. Electronic address: lylemai@sina.cn.
authors.forename: Yali
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Lab of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. Electronic address: lmsnouc@ouc.edu.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China. Electronic address: liujiangyun@suda.edu.cn.
authors.forename: Jiangyun
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: Shilin
authors.initials: S
authors.lastname: Yang
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008968:Molecular Conformation; D009828:Oleanolic Acid / Q000737:chemistry / Q000494:pharmacology*; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014312:Trisaccharides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D012503:Saponins; D014312:Trisaccharides; D009828:Oleanolic Acid
keywords: Antiproliferation activity; Glycosylation; Triterpenoid saponin; β-hederin