title: Ethnic disparities relative to disease features and outcomes in children with acute myeloid leukemia.
abstract: Hispanics with acute leukemias have poorer outcomes than non-Hispanic whites (NHWs), despite an increased likelihood of favorable prognostic features. We reviewed medical records from 167 children ages 0-18 years diagnosed with de novo AML over an 18-year period at Texas Children's Cancer Center, among whom 129 self-identified as Hispanic or NHW. Although Hispanics were significantly more likely to have the favorable prognostic cytogenetic feature t(8;21) (P = 0.04), the expected survival benefit was not observed. This lack of survival benefit was primarily due to significantly poorer event-free and overall survival among Hispanics treated with upfront stem cell transplantation after achieving first clinical remission (P = 0.008).
authors.affiliation: Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.
authors.forename: M Monica
authors.initials: MM
authors.lastname: Gramatges
authors.affiliation: University of Texas School of Public Health, Houston, Texas.
authors.forename: Aditya
authors.initials: A
authors.lastname: Deshpande
authors.affiliation: Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.|University of Texas School of Public Health, Houston, Texas.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Lupo
authors.affiliation: Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Rau
authors.affiliation: Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.
authors.forename: Michele L
authors.initials: ML
authors.lastname: Redell
authors.affiliation: Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.
authors.forename: Terzah M
authors.initials: TM
authors.lastname: Horton
authors.affiliation: Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.|University of Texas School of Public Health, Houston, Texas.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Scheurer
authors.affiliation: Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas.
authors.forename: Karen R
authors.initials: KR
authors.lastname: Rabin
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006630:Hispanic or Latino; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy; D008297:Male; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D044465:White People
keywords: acute myeloid leukemia; bone marrow transplant; ethnicity; outcomes