title: Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release.
abstract: Three polyether-ester triblock diols, with various molecular weights, were synthesized from ε-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked polyurethane films via UV initiated polymerization with and without cargo incorporation. Degradation experiment indicated that in PBS/H2O2/CoCl2the films degraded rapidly compared to PBS alone or with lipase. The polyurethane membrane loaded with the antibiotic tetracycline, demonstrated prolonged release over 200h, suggesting that the polymers could be used as an implant coating for controlled drug release.
authors.affiliation: School of Materials Science& Engineering, Changzhou University, Changzhou 213164, China.
authors.forename: Xuepeng
authors.initials: X
authors.lastname: Feng
authors.affiliation: School of Materials Science& Engineering, Changzhou University, Changzhou 213164, China.
authors.forename: Guirong
authors.initials: G
authors.lastname: Wang
authors.affiliation: School of Chemistry, EaStCHEM, University of Edinburgh, Joseph Black Building, EH9 3FJ, UK.
authors.forename: Kevin
authors.initials: K
authors.lastname: Neumann
authors.affiliation: School of Materials Science& Engineering, Changzhou University, Changzhou 213164, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yao
authors.affiliation: School of Materials Science& Engineering, Changzhou University, Changzhou 213164, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ding
authors.affiliation: School of Materials Science& Engineering, Changzhou University, Changzhou 213164, China.
authors.forename: Songyan
authors.initials: S
authors.lastname: Li
authors.affiliation: School of Materials Science& Engineering, Changzhou University, Changzhou 213164, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: School of Materials Science& Engineering, Changzhou University, Changzhou 213164, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: School of Chemistry, EaStCHEM, University of Edinburgh, Joseph Black Building, EH9 3FJ, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Bradley
authors.affiliation: School of Materials Science& Engineering, Changzhou University, Changzhou 213164, China. Electronic address: rzhang@cczu.edu.cn.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
mesh_terms: D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D065546:Drug Liberation; D055119:Elastic Modulus; D004926:Escherichia coli / Q000187:drug effects; D005027:Ethylene Oxide / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007783:Lactones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry; D058105:Polymerization / Q000528:radiation effects; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000737:chemistry*; D013752:Tetracycline / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: D003692:Delayed-Action Preparations; D007783:Lactones; C400421:PLC(20)-b-PEO(44); D011091:Polyesters; D011140:Polyurethanes; D013752:Tetracycline; D005027:Ethylene Oxide
keywords: Biodegradable; Controlled drug release; Poly(ether-ester); Polyurethane acrylates; Tetracycline