title: An Agent-Based Clustering Approach for Gene Selection in Gene Expression Microarray.
abstract: Gene selection is a major research area in microarray analysis, which seeks to discover differentially expressed genes for a particular target annotation. Such genes also often called informative genes are able to differentiate tissue samples belonging to different classes of the studied disease. Despite the fact that there is a wide number of proposals, the complexity imposed by this problem remains a challenge today. This research proposes a gene selection approach by means of a clustering-based multi-agent system. This proposal manages different filter methods and gene clustering through coordinated agents to discover informative gene subsets. To assess the reliability of our approach, we have used four important and public gene expression datasets, two Lung cancer datasets, Colon and Leukemia cancer dataset. The achieved results have been validated through cluster validity measures, visual analytics, a classifier and compared with other gene selection methods, proving the reliability of our proposal.
authors.affiliation: University of Salamanca, IBSAL/BISITE Research Group, Edificio I+D+i, 37007, Salamanca, Spain.
authors.forename: Juan
authors.identifier: http://orcid.org/0000-0002-9452-1477
authors.initials: J
authors.lastname: Ramos
authors.affiliation: University of Salamanca, IBSAL/BISITE Research Group, Edificio I+D+i, 37007, Salamanca, Spain. jantonio@usal.es.|University of Coimbra, CISUC, ECOS Research Group, Pólo II, Pinhal de Marrocos, 3030-290, Coimbra, Portugal. jantonio@usal.es.
authors.forename: José A
authors.initials: JA
authors.lastname: Castellanos-Garzón
authors.affiliation: University of Salamanca, IBSAL/BISITE Research Group, Edificio I+D+i, 37007, Salamanca, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: González-Briones
authors.affiliation: University of Salamanca, IBSAL/BISITE Research Group, Edificio I+D+i, 37007, Salamanca, Spain.
authors.forename: Juan F
authors.initials: JF
authors.lastname: de Paz
authors.affiliation: University of Salamanca, IBSAL/BISITE Research Group, Edificio I+D+i, 37007, Salamanca, Spain.|Osaka Institute of Technology, Osaka, 535-8585, Japan.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Corchado
mesh_terms: D000465:Algorithms; D016000:Cluster Analysis; D000069550:Machine Learning; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*
keywords: Classification; Clustering; DNA-microarray; Filter method; Gene selection; Machine learning; Multi-agent system; Visual analytics