title: Dual-TRACER: High resolution fMRI with constrained evolution reconstruction.
abstract: fMRI with high spatial resolution is beneficial for studies in psychology and neuroscience, but is limited by various factors such as prolonged imaging time, low signal to noise ratio and scarcity of advanced facilities. Compressed Sensing (CS) based methods for accelerating fMRI data acquisition are promising. Other advanced algorithms like k-t FOCUSS or PICCS have been developed to improve performance. This study aims to investigate a new method, Dual-TRACER, based on Temporal Resolution Acceleration with Constrained Evolution Reconstruction (TRACER), for accelerating fMRI acquisitions using golden angle variable density spiral. Both numerical simulations and in vivo experiments at 3T were conducted to evaluate and characterize this method. Results show that Dual-TRACER can provide functional images with a high spatial resolution (1×1mm2) under an acceleration factor of 20 while maintaining hemodynamic signals well. Compared with other investigated methods, dual-TRACER provides a better signal recovery, higher fMRI sensitivity and more reliable activation detection.
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Xuesong
authors.initials: X
authors.lastname: Li
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Ma
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China; Philips Healthcare, Shanghai, China.
authors.forename: Lyu
authors.initials: L
authors.lastname: Li
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.affiliation: FMRIB Centre, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford OX3 9DU, UK.
authors.forename: Yan
authors.initials: Y
authors.lastname: Tong
authors.affiliation: Department of Psychiatry, University of Connecticut Health Center, Farmington, CT, USA; Department of Psychiatry and Behavioral Science, Duke University, Durham, NC, USA.
authors.forename: Lihong
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.lastname: Sen Song
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China. Electronic address: huaguo@tsinghua.edu.cn.
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*
keywords: Dual-TRACER; High resolution; TRACER; Variable density spiral; fMRI