title: The association between subjective memory complaint and objective cognitive function in older people with previous major depression.
abstract: The goal of this study is to investigate associations between subjective memory complaint and objective cognitive performance in older people with previous major depression-a high-risk sample for cognitive impairment and later dementia. A cross-sectional study was carried out in people aged 60 or over with previous major depression but not fulfilling current major depression criteria according to DSM-IV-TR. People with dementia or Mini-Mental State Examination score less than 17 were excluded. Subjective memory complaint was defined on the basis of a score ≧4 on the subscale of Geriatric Mental State schedule, a maximum score of 8. Older people aged equal or over 60 without any psychiatric diagnosis were enrolled as healthy controls. Cognitive function was evaluated using a series of cognitive tests assessing verbal memory, attention/speed, visuospatial function, verbal fluency, and cognitive flexibility in all participants. One hundred and thirteen older people with previous major depression and forty-six healthy controls were enrolled. Subjective memory complaint was present in more than half of the participants with depression history (55.8%). Among those with major depression history, subjective memory complaint was associated with lower total immediate recall and delayed verbal recall scores after adjustment. The associations between subjective memory complaint and worse memory performance were stronger in participants with lower depressive symptoms (Hamilton Depression Rating Scale score<7). The results suggest subjective memory complaint may be a valid appraisal of memory performance in older people with previous major depression and consideration should be given to more proactive assessment and follow-up in these clinical samples.
authors.affiliation: Department of Psychiatry, Cardinal Tien Hospital, New Taipei City, Taiwan.
authors.forename: Chung-Shiang
authors.initials: CS
authors.lastname: Chu
authors.affiliation: Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: I-Wen
authors.initials: IW
authors.lastname: Sun
authors.affiliation: King's College London (Institute of Psychiatry), Department of Psychological Medicine, London, United Kindom.
authors.forename: Aysha
authors.initials: A
authors.lastname: Begum
authors.affiliation: Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: Shen-Ing
authors.initials: SI
authors.lastname: Liu
authors.affiliation: Department of Psychiatry, Cathay General Hospital, Taipei, Taiwan.
authors.forename: Ching-Jui
authors.initials: CJ
authors.lastname: Chang
authors.affiliation: Department of Psychiatry, Cathay General Hospital, Taipei, Taiwan.|School of Medicine, Fu Jen Catholic University, Taipei, Taiwan.
authors.forename: Wei-Che
authors.initials: WC
authors.lastname: Chiu
authors.affiliation: Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.|Department of Psychiatry, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan.
authors.forename: Chin-Hsin
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, Taipei City Hospital, Songde Branch, Taipei, Taiwan.
authors.forename: Hwang-Shen
authors.initials: HS
authors.lastname: Tang
authors.affiliation: Department of Family Medicine, Taipei City Hospital, Zhongxing Branch, Taipei, Taiwan.
authors.forename: Chia-Li
authors.initials: CL
authors.lastname: Yang
authors.affiliation: Department of Family Medicine, Shuang-Ho Hospital, Taipei Medical University, New Taipei, Taiwan.|Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Ying-Chin
authors.initials: YC
authors.lastname: Lin
authors.affiliation: Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.|Department of Psychiatry, Taipei City Hospital, Songde Branch, Taipei, Taiwan.
authors.forename: Chih-Chiang
authors.identifier: http://orcid.org/0000-0002-5475-230X
authors.initials: CC
authors.lastname: Chiu
authors.affiliation: King's College London (Institute of Psychiatry), Department of Psychological Medicine, London, United Kindom.
authors.forename: Robert
authors.initials: R
authors.lastname: Stewart
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003071:Cognition; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D012307:Risk Factors