title: Nonrandom occurrence of lymphoid cancer types in 140 families.
abstract: We studied 140 families with two or more lymphoid cancers, including non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), chronic lymphocytic leukemia (CLL), and multiple myeloma (MM), for deviation from the population age of onset and lymphoid cancer co-occurrence patterns. Median familial NHL, HL, CLL and MM ages of onset are substantially earlier than comparable population data. NHL, HL and CLL (but not MM) also show earlier age of onset in later generations, known as anticipation. The co-occurrence of lymphoid cancers is significantly different from that expected based on population frequencies (p < .0001), and the pattern differs more in families with more affected members (p < .0001), suggesting specific lymphoid cancer combinations have a shared genetic basis. These families provide evidence for inherited factors that increase the risk of multiple lymphoid cancers. This study was approved by the BC Cancer Agency - University of British Columbia Clinical Research Ethics Board.
authors.affiliation: a Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency , Vancouver , British Columbia , Canada.|b Department of Medical Genetics , University of British Columbia , Vancouver , British Columbia , Canada.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Jones
authors.affiliation: c Department of Statistics and Actuarial Science , Simon Fraser University , Burnaby , British Columbia , Canada.
authors.forename: Jackson
authors.initials: J
authors.lastname: Voong
authors.affiliation: a Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency , Vancouver , British Columbia , Canada.
authors.forename: Ruth
authors.initials: R
authors.lastname: Thomas
authors.affiliation: a Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency , Vancouver , British Columbia , Canada.
authors.forename: Amy
authors.initials: A
authors.lastname: English
authors.affiliation: a Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency , Vancouver , British Columbia , Canada.
authors.forename: Johanna
authors.initials: J
authors.lastname: Schuetz
authors.affiliation: d Centre for Lymphoid Cancer, British Columbia Cancer Agency , Vancouver , British Columbia , Canada.|e Department of Pathology & Laboratory Medicine , British Columbia Cancer Agency , Vancouver , BC , Canada.
authors.forename: Graham W
authors.initials: GW
authors.lastname: Slack
authors.affiliation: c Department of Statistics and Actuarial Science , Simon Fraser University , Burnaby , British Columbia , Canada.
authors.forename: Jinko
authors.initials: J
authors.lastname: Graham
authors.affiliation: d Centre for Lymphoid Cancer, British Columbia Cancer Agency , Vancouver , British Columbia , Canada.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Connors
authors.affiliation: a Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency , Vancouver , British Columbia , Canada.|f Department of Biomedical Physiology and Kinesiology , Simon Fraser University , Burnaby , British Columbia , Canada.
authors.forename: Angela
authors.initials: A
authors.lastname: Brooks-Wilson
mesh_terms: D017668:Age of Onset; D020132:Anticipation, Genetic; D004198:Disease Susceptibility; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007945:Leukemia, Lymphoid / Q000453:epidemiology* / Q000209:etiology; D008223:Lymphoma / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D010375:Pedigree; D018426:SEER Program
keywords: Familial lymphoma; anticipation; co-occurrence; genetic susceptibility