title: Alternative Biomarkers for Combined Biology.
abstract: Chemotherapy-related cardiac dysfunction (CRCD) has challenged clinicians to hesitate in using cardiotoxic agents such as anthracycline and several protein kinase inhibitors. As early detection of CRCD and timely cessation of cardiotoxic agents became a strategy to avoid CRCD, cardiac troponin and natriuretic peptide are measured to monitor cardiotoxicity; however, there are inconsistencies in their predictability of CRCD. Alternative biomarkers have been researched extensively for potential use as more sensitive and accurate biomarkers. The mechanisms of CRCD and previous studies on traditional and novel biomarkers for CRCD are examined to enlighten future direction of investigation in this combined biology.
authors.affiliation: Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA; Cardiovascular Medicine, Korea University College of Medicine, Korea University Medical Center Ansan Hospital, 123 Jeokgeum-ro, Ansan-si 15355, Korea.
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kirsop
authors.affiliation: Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Center for Clinical Genomics, Cleveland Clinic, Cleveland, OH, USA. Electronic address: tangw@ccf.org.
authors.forename: Wai Hong Wilson
authors.initials: WH
authors.lastname: Tang
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000494:pharmacology; D015415:Biomarkers / Q000378:metabolism*; D042241:Early Diagnosis; D006331:Heart Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D057170:Translational Research, Biomedical; D020107:Troponin T / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D020107:Troponin T; D020097:Natriuretic Peptide, Brain
keywords: Biomarkers; Chemotherapy-related cardiac dysfunction; Heart failure; Malignancy