title: Show drugs work before selling them.
authors.affiliation: RIKEN Center for Developmental Biology in Kobe, Japan, and visiting professor at Keio University School of Medicine and Global Research Institute, Tokyo.
authors.forename: Douglas
authors.initials: D
authors.lastname: Sipp
authors.affiliation: University of Alberta, Edmonton, Canada.
authors.forename: Christopher
authors.initials: C
authors.lastname: McCabe
authors.affiliation: Department of Cell and Molecular Therapies at Royal Prince Alfred Hospital in Sydney, Australia.
authors.forename: John E J
authors.initials: JE
authors.lastname: Rasko
mesh_terms: D000409:Alanine / Q000009:adverse effects / Q000031:analogs & derivatives; D001381:Azepines / Q000009:adverse effects; D002648:Child; D002986:Clinical Trials as Topic / Q000191:economics / Q000941:ethics / Q000331:legislation & jurisprudence; D017277:Drug Approval / Q000191:economics* / Q000266:history / Q000331:legislation & jurisprudence*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000191:economics / Q000517:prevention & control*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007066:Iduronate Sulfatase / Q000627:therapeutic use; D018803:Models, Economic; D016532:Mucopolysaccharidosis II / Q000188:drug therapy; D061214:Patient Safety / Q000191:economics / Q000266:history / Q000331:legislation & jurisprudence*; D004364:Pharmaceutical Preparations / Q000191:economics* / Q000592:standards; D011804:Quinolines / Q000009:adverse effects; D015203:Reproducibility of Results; D013792:Thalidomide / Q000009:adverse effects / Q000266:history; D014481:United States; D014486:United States Food and Drug Administration / Q000191:economics / Q000266:history / Q000331:legislation & jurisprudence*
chemical_list: D001381:Azepines; C484278:N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide; D004364:Pharmaceutical Preparations; D011804:Quinolines; C483909:torcetrapib; D013792:Thalidomide; D007066:Iduronate Sulfatase; C517982:idursulfase; D000409:Alanine