title: Metabolomics-assisted biotechnological interventions for developing plant-based functional foods and nutraceuticals.
abstract: Today, the dramatic changes in types of food consumed have led to an increased burden of chronic diseases. Therefore, the emphasis of food research is not only to ensure quality food that can supply adequate nutrients to prevent nutrition related diseases, but also to ensure overall physical and mental-health. This has led to the concept of functional foods and nutraceuticals (FFNs), which can be ideally produced and delivered through plants. Metabolomics can help in getting the most relevant functional information, and thus has been considered the greatest -OMICS technology to date. However, metabolomics has not been exploited to the best potential in plant sciences. The technology can be leveraged to identify the health promoting compounds and metabolites that can be used for the development of FFNs. This article reviews (i) plant-based FFNs-related metabolites and their health benefits; (ii) use of different analytic platforms for targeted and non-targeted metabolite profiling along with experimental considerations; (iii) exploitation of metabolomics to develop FFNs in plants using various biotechnological tools; and (iv) potential use of metabolomics in plant breeding. We have also provided some insights into integration of metabolomics with latest genome editing tools for metabolic pathway regulation in plants.
authors.affiliation: a Department of Horticulture , University of Wisconsin-Madison , Madison , Wisconsin , USA.
authors.forename: Arun
authors.identifier: http://orcid.org/0000-0002-0106-2735
authors.initials: A
authors.lastname: Kumar
authors.affiliation: b Department of Applied Biology , College of Sciences, University of Sharjah , Sharjah , United Arab Emirates.|c Department of Biotechnology , Faculty of Agriculture, Al-Azhar University , Cairo , Egypt.
authors.forename: Kareem A
authors.identifier: http://orcid.org/0000-0003-2433-4278
authors.initials: KA
authors.lastname: Mosa
authors.affiliation: d Plant Science Department , McGill University , Quebec , Canada.
authors.forename: Liyao
authors.identifier: http://orcid.org/0000-0002-1969-5813
authors.initials: L
authors.lastname: Ji
authors.affiliation: d Plant Science Department , McGill University , Quebec , Canada.
authors.forename: Udaykumar
authors.initials: U
authors.lastname: Kage
authors.affiliation: d Plant Science Department , McGill University , Quebec , Canada.
authors.forename: Dhananjay
authors.initials: D
authors.lastname: Dhokane
authors.affiliation: d Plant Science Department , McGill University , Quebec , Canada.
authors.forename: Shailesh
authors.initials: S
authors.lastname: Karre
authors.affiliation: e Department of Food Science and Nutrition , College of Home Science, University of Agricultural Science , Dharwad , India.
authors.forename: Deepa
authors.initials: D
authors.lastname: Madalageri
authors.affiliation: f Department of Soil Sciences , Punjab Agricultural University , Ludhiana , India.
authors.forename: Neemisha
authors.identifier: http://orcid.org/0000-0001-8673-8249
authors.initials: N
authors.lastname: Pathania
mesh_terms: D000470:Alkaloids / Q000032:analysis; D001709:Biotechnology; D016208:Databases, Factual; D019587:Dietary Supplements / Q000032:analysis*; D005227:Fatty Acids / Q000032:analysis; D055951:Functional Food / Q000032:analysis*; D018745:Genome, Plant; D006801:Humans; D055432:Metabolomics; D064209:Phytochemicals / Q000032:analysis; D010944:Plants / Q000737:chemistry; D030821:Plants, Genetically Modified / Q000235:genetics; D059808:Polyphenols / Q000032:analysis; D013729:Terpenes / Q000032:analysis
chemical_list: D000470:Alkaloids; D005227:Fatty Acids; D064209:Phytochemicals; D059808:Polyphenols; D013729:Terpenes
keywords: Functional foods and nutraceuticals; metabolic engineering; metabolic pathway regulation; metabolomics; metabolomics assisted breeding; secondary metabolites