title: The effect of newer antiepileptic drugs in combination therapy.
abstract: To assess the impact of the new AEDs on overall outcome for patients with epilepsy.
  
  
  
  In 2004, the effect of combination therapy on seizure frequency in adult patients with focal epilepsy was evaluated in a cross-sectional study in our center. We repeated this analysis ten years and eight new antiepileptic drugs (AED) later.
  
  
  
  In 2014, a higher percentage of patients with polytherapy (117 out of 396; 30%) were seizure-free compared with the original analysis (22%) (p=0.042). Eighty three out of 218 (38%) subjects on duo-therapy were seizure-free (27% in 2004) (p=0.040); in the 151 receiving triple therapy there were 30 (20%) seizure-free subjects (10% in 2004). Four out of 27 subjects (15%) with four AEDs were seizure-free (0% in 2004). The most common pairing of 52 different combinations for duo-therapy was levetiracetam-oxcarbazepine. Eighty different AEDs regimens were being used in the patients administered three AEDs.
  
  
  
  Our combined data from these two studies indicate that some patients with focal epilepsy might benefit from newer AEDs as an adjunctive therapy in the hope they could acquire seizure freedom.
authors.affiliation: Department of Neurology, Tampere University Hospital, PO BOX 2000, 33521, Tampere, Finland. Electronic address: Jussi.Makinen@pshp.fi.
authors.forename: Jussi
authors.initials: J
authors.lastname: Mäkinen
authors.affiliation: Department of Neurology, Tampere University Hospital, PO BOX 2000, 33521, Tampere, Finland. Electronic address: Sirpa.Rainesalo@pshp.fi.
authors.forename: Sirpa
authors.initials: S
authors.lastname: Rainesalo
authors.affiliation: School of Health Sciences, University of Tampere, Finland; UKK Institute for Health Promotion, Tampere, Finland. Electronic address: Jani.Raitanen@staff.uta.fi.
authors.forename: Jani
authors.initials: J
authors.lastname: Raitanen
authors.affiliation: Department of Neurology, University of Tampere and Tampere University Hospital, PO BOX 2000, 33521, Tampere, Finland. Electronic address: Jukka.Peltola@pshp.fi.
authors.forename: Jukka
authors.initials: J
authors.lastname: Peltola
mesh_terms: D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination / Q000379:methods; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D008875:Middle Aged; D000078330:Oxcarbazepine; D010889:Piracetam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012189:Retrospective Studies; D012640:Seizures / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D000077287:Levetiracetam; D000078330:Oxcarbazepine; D010889:Piracetam
keywords: Combination therapy; Epilepsy; New AEDs; Seizures