title: Directionally-sensitive peripheral nerve recording: bipolar nerve cuff design.
abstract: Although bipolar nerve cuff electrodes (NCEs) are used in clinical neurostimulation therapies (e.g., epilepsy, obstructive sleep apnea), the use of this electrode as part of a closed-up controlled system is very limited. The literature points to high noise content (i.e., poor signal-to-noise ratio, SNR) as the primary reason for not using bipolar NCEs to record neural activity. In fact, over the past several decades, the pseudo-tripolar NCEs, the symmetric configuration of this electrode array (i.e., electrically-shorted side contacts) makes it very difficult to obtain directional information from the recorded neural activity (efferent vs. afferent). In this study, we investigated the feasibility of using a bipolar NCE to achieve low-noise, directionally-sensitive recording of peripheral nerve activity.
authors.forename: Parisa
authors.initials: P
authors.lastname: Sabetian
authors.forename: Milos R
authors.initials: MR
authors.lastname: Popovic
authors.forename: Paul B
authors.initials: PB
authors.lastname: Yoo
mesh_terms: D000200:Action Potentials; D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D004566:Electrodes; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D010525:Peripheral Nerves / Q000502:physiology*; D059629:Signal-To-Noise Ratio