title: Is Serum Prostate-specific Antigen a Diagnostic Marker for Benign and Malignant Breast Tumors in Women.
abstract: BACKGROUND
  Breast cancer is the most common cancer in women. Prostrate-specific antigen (PSA) is a marker of prostate gland malignancy which has been considered in cases with breast cancer in recent years. The goal of this study was to determine total and free PSA levels in cases with malignant and benign breast lesions.
  
  
  METHODS
  Ninety women with histological proved malignant breast masses and 90 with benign breast masses were enrolled. Total and free PSA levels along with histological grade and conditions of vascular and perinural invasion, status of hormonal tumor receptors, immune-histo-chemistry markers recorded for all cases. Total and free PSA levels were assessed after treatment in cases with malignant masses.
  
  
  RESULTS
  Total and free PSA levels were significantly higher in cases with malignant masses. The best cut off point for total PSA to differentiate benign and malignant masses was 0.31 and the best cut off point for free PSA to differentiate benign and malignant masses was 0.19. After treatment, mean free PSA level was significantly lower than free PSA before treatment (0.23 vs 0.3, p<0.001).
  
  
  CONCLUSIONS
  Serum PSA level could be applied for differentiating benign and malignant breast masses.
authors.affiliation: Department of Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Hasan Emami
authors.initials: SHE
authors.lastname: Razavi
authors.affiliation: Brain and Spinal Cord Injury Research Center (BASIR), Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Ghajarzadeh
authors.affiliation: Department of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Abdollahi
authors.affiliation: Department of Nephrology and Dialysis, "Dr. Carol Davila" Hospital of Nephrology, Bucharest, Romania.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Taran
authors.affiliation: Department of Nephrology and Dialysis, "Dr. Carol Davila" Hospital of Nephrology, Bucharest, Romania.
authors.forename: Saeed
authors.initials: S
authors.lastname: Shoar
authors.affiliation: Department of Surgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Omranipour