title: [Impact of crosslinking on corneal epithelial healing].
abstract: OBJECTIVE
  To analyse the effect of crosslinking (CXL) on corneal epithelial healing.
  
  
  METHODS
  39 keratoconus patients following CXL and 11 patients following PRK were enrolled in this study. 21, 45 and 69 hours after CXL and 16, 37 and 61 hours following PRK slitlamp photographs were taken using fluorescein staining and the size of the epithelial defect and the time of epithelial closure was determined. As the observation time-points differed in both groups, the size of the epithelial defect following PRK was calculated for the time points used for analysis of CXL patients. These data were compared using chi-quadrat test.
  
  
  RESULTS
  Following crosslinking, epithelial closure occured within 3, following PRK within 4 days. In the area of epithelial erosion 45 and 69 hours after CXL or PRK treatment statistically significant difference (p = 0.005 and p<0.001) was verified.
  
  
  CONCLUSIONS
  Our results show beneficial effect of crosslinking on corneal epithelial healing. Orv. Hetil., 2017, 158(10), 376-379.
authors.affiliation: Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Mária utca 39., 1085.
authors.forename: Andrea
authors.initials: A
authors.lastname: Gyenes
authors.affiliation: Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Mária utca 39., 1085.|Klinik für Augenheilkunde, Universität des Saarlandes, UKS Homburg/Saar.
authors.forename: Nóra
authors.initials: N
authors.lastname: Szentmáry
authors.affiliation: Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Mária utca 39., 1085.
authors.forename: Gábor
authors.initials: G
authors.lastname: Tóth
authors.affiliation: Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Mária utca 39., 1085.
authors.forename: Huba
authors.initials: H
authors.lastname: Kiss
authors.affiliation: Egészségtudományi Kar, Semmelweis Egyetem Budapest.
authors.forename: Csaba
authors.initials: C
authors.lastname: Szekrényesi
authors.affiliation: Exprimentelle Ophthalmologie, Universität des Saarlandes Homburg/Saar.
authors.forename: Achim
authors.initials: A
authors.lastname: Langenbucher
authors.affiliation: Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Mária utca 39., 1085.
authors.forename: Zoltán Zsolt
authors.initials: ZZ
authors.lastname: Nagy
mesh_terms: D003432:Cross-Linking Reagents / Q000627:therapeutic use*; D019573:Epithelium, Corneal / Q000187:drug effects*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use; D007640:Keratoconus / Q000188:drug therapy*; D008297:Male; D018903:Photorefractive Keratectomy / Q000379:methods*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D003432:Cross-Linking Reagents; D006820:Hyaluronic Acid
keywords: corneal epithelial healing; crosslinking; fotorefraktív keratectomia; hámgyógyulás; photorefractive keratectomy