title: Study of Serum Uric Acid Levels in Myocardial Infarction and Its Association With Killip Class.
abstract: The present study aimed to compare the serum level of uric acid in patients with and without heart failure and also to determine the association between uric acid level and clinical status by Killip class in patients with STEMI. This case-control study was conducted on 50 consecutives as control group and 50 patients with acute heart failure, (20 patients had acute STEMI), who documented by both clinical conditions and echocardiography assessment. The mean plasma level of uric acid in the case group was 7.6±1.6 milligrams/deciliter (mg/dL) and in the control group was 4.5±1.5 respectively (P<0.001). These values in patients with STEMI was about 9.2±0.86, but in patients with acute heart failure in absence of STEMI was 6.5±1.04 (P<0.001). Moreover, there was significant difference among the level of uric acid and Killip classes (P<0.001). Also there was significant difference for uric acid level between HFrEF (HF with reduced EF) and severe LV systolic dysfunction (0.049). In STEMI patients with culprit LAD, mean uric acid was significantly higher than cases with culprit LCX [(9.7±0.98 versus 8.6±0.52 respectively) P=0.012]. Regarding  treatment plan in patients with STEMI, mean level of uric acid in those considered for CABG was significantly higher than who were considered for PCI, 9.9±0.82 versus 8.9±0.76 respectively, P=0.029. In STEMI patients with higher killip class, higher level of uric acid was seen. Also, the severity of LV systolic dysfunction was associated with higher level of uric acid.
authors.affiliation: Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Mehrpooya
authors.affiliation: Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Farnoosh
authors.initials: F
authors.lastname: Larti
authors.affiliation: Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Younes
authors.initials: Y
authors.lastname: Nozari
authors.affiliation: Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Sattarzadeh-Badkoobeh
authors.affiliation: Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Amir Farhang
authors.initials: AF
authors.lastname: Zand Parsa
authors.affiliation: Department of Electronic Learning in Medical Education, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Jayran
authors.initials: J
authors.lastname: Zebardast
authors.affiliation: Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Anahita
authors.initials: A
authors.lastname: Tavoosi
authors.affiliation: Department of Biology, Payame Noor University, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Shahbazi
mesh_terms: D000208:Acute Disease; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000145:classification / Q000150:complications; D013599:Systole; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Heart failure; Killip class; Myocardial infarction; Uric acid