title: Label and label-free based surface-enhanced Raman scattering for pathogen bacteria detection: A review.
abstract: Rapid, accurate detection of pathogen bacteria is a highly topical research area for the sake of food safety and public health. Surface-enhanced Raman scattering (SERS) is being considered as a powerful and attractive technique for pathogen bacteria detection, due to its sensitivity, high speed, comparatively low cost, multiplexing ability and portability. This contribution aims to give a comprehensive overview of SERS as a technique for rapid detection of pathogen bacteria based on label and label-free strategies. A brief tutorial on SERS is given first of all. Then we summarize the recent trends and developments of label and label-free based SERS applied to detection of pathogen bacteria, including the relatively complete interpretation of SERS spectra. In addition, multifunctional SERS platforms for pathogen bacteria in matrix are discussed as well. Furthermore, an outlook of the work done and a perspective on the future directions of SERS as a reliable tool for real-time pathogen bacteria detection are given.
authors.affiliation: Department of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medical School of Ningbo University, Ningbo, Zhejiang 315211, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medical School of Ningbo University, Ningbo, Zhejiang 315211, China.
authors.forename: Guangxia
authors.initials: G
authors.lastname: Yu
authors.affiliation: Department of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medical School of Ningbo University, Ningbo, Zhejiang 315211, China. Electronic address: yangdanting@nbu.edu.cn.
authors.forename: Danting
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medical School of Ningbo University, Ningbo, Zhejiang 315211, China.
authors.forename: Jinshun
authors.initials: J
authors.lastname: Zhao
mesh_terms: D001419:Bacteria / Q000302:isolation & purification* / Q000472:pathogenicity; D015374:Biosensing Techniques / Q000379:methods*; D059022:Food Safety; D006801:Humans; D007239:Infections / Q000175:diagnosis* / Q000382:microbiology; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D012834:Silver
keywords: Label method; Label-free method; Multifunctional detection platform; Pathogen bacteria; Surface-enhanced Raman scattering