title: Population genetic analysis and genome-wide association study of patellar luxation in a Thai population of Pomeranian dogs.
abstract: The genetics of patellar luxation (PL) were investigated in Pomeranian dogs presented at the Small Animal Hospital, Faculty of Veterinary Science, Chulalongkorn University. A cohort of 339 Pomeranian dogs, part of a four-generation pedigree of 842 Pomeranians, was screened for PL from 2006 to 2013. PL was present in 77% of the screened dogs, with 84% having bilateral and 16% unilateral luxation. Medial PL was more common (95%) than lateral PL (2%) or bidirectional PL (3%). The risk of PL was similar in male and female dogs (female:male relative risk 1.11, 95% CI 0.98-1.25). The heritability of PL in the screened population was 0.44±0.04 using a threshold model. A genome-wide association study of PL (48 cases and 48 controls) using a high-density SNP array indicated the possible involvement of 15 chromosomal regions, of which CFA05 and CFA32 remained associated in a larger study involving an additional 128 cases and 7 controls. Candidate genes in these regions may be involved in the pathogenesis of PL in Pomeranian dogs.
authors.affiliation: Department of Veterinary Surgery, Faculty of Veterinary Science, Chulalongkorn University, 39 Henri Dunant, Bangkok 10330, Thailand; Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands. Electronic address: c.wangdee@hotmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Wangdee
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands.
authors.forename: P A J
authors.initials: PA
authors.lastname: Leegwater
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands; Animal Breeding and Genomics Centre, Wageningen University, P.O. Box 338, 6700 AH Wageningen, The Netherlands.
authors.forename: H C M
authors.initials: HC
authors.lastname: Heuven
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands.
authors.forename: F G
authors.initials: FG
authors.lastname: van Steenbeek
authors.affiliation: Department of Obstetrics, Gynaecology and Reproduction, Faculty of Veterinary Science, Chulalongkorn University, 39 Henri Dunant, Bangkok 10330, Thailand.
authors.forename: M
authors.initials: M
authors.lastname: Techakumphu
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands.
authors.forename: H A W
authors.initials: HA
authors.lastname: Hazewinkel
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics*; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D008297:Male; D031222:Patellar Dislocation / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D010375:Pedigree; D013785:Thailand / Q000453:epidemiology
keywords: Canis lupus familiaris; Genome-wide association study; Heritability; Patellar luxation; Prevalence