title: Expressions of Immune Negative Regulator FoxP3+Treg and PD-L1 Protein in the Immune Microenvironment of Cervical Lesion.
abstract: Objective To explore the expression patterns of immune negative regulator FoxP3+Treg and PD-L1 protein in cervical carcinoma and its precancerous lesions. Methods The expression patterns of FoxP3+Treg and PD-L1 protein in 45 cases of cervical lesions tissues of the cervix and 20 cases of normal cervix tissues by using immunohistochemistry (IHC). Results Compared with the normal cervix,the expressions of FoxP3+Treg (H=43.211,P=0.000) and PD-L1 protein (t=213.00,P=0.001) were significantly increased in cervical lesions. Compared with the low-grade squamous cell carcinoma,the invasiveness of FoxP3+Treg was increased in high-grade squamous cell carcinoma (H=28.307,P=0.000),along with increased expression of PD-L1 protein (t=239.000,P=0.028). The FoxP3+Treg expression was positively correlated with PD-L1 protein expression in abnormally differentiated cells (rs=0.364,P=0.003). Conclusion Along with the progression of cervical cancer,the FoxP3+Treg amount increases in the local microenvironment,along with enhanced PD-L1 protein expression in abnormally differentiated cells.
authors.affiliation: Department of Gynecology,Yan'an Hospital Affiliated to Kunming Medical University,Kunming 650051,China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Obstetrics and Gynecology the First Affiliated Hospital,Xi'an Jiaotong University,Xi'an 710061,China.
authors.forename: Minyi
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Obstetrics and Gynecology the First Affiliated Hospital,Xi'an Jiaotong University,Xi'an 710061,China.
authors.forename: Xing
authors.initials: X
authors.lastname: Wei
authors.affiliation: Department of Obstetrics and Gynecology the First Affiliated Hospital,Xi'an Jiaotong University,Xi'an 710061,China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Obstetrics and Gynecology the First Affiliated Hospital,Xi'an Jiaotong University,Xi'an 710061,China.
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology the First Affiliated Hospital,Xi'an Jiaotong University,Xi'an 710061,China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Pathology, the First Affiliated Hospital,Xi'an Jiaotong University,Xi'an 710061,China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology the First Affiliated Hospital,Xi'an Jiaotong University,Xi'an 710061,China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Yang
mesh_terms: D060890:B7-H1 Antigen / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D059016:Tumor Microenvironment / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000276:immunology*
chemical_list: D060890:B7-H1 Antigen; C423236:CD274 protein, human; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors