title: Successful adalimumab treatment and usefulness of capsule endoscopy for gut inflammation concomitant with ankylosing spondylitis.
abstract: Here we describe a 20-year-old man with ankylosing spondylitis and gut inflammation, who was successfully treated with adalimumab. Capsule endoscopy and ileocolonoscopy showed multiple erosions and aphthoid ulcers in the ileum and the ileocecal valve. Immunohistochemical analysis of the terminal ileum demonstrated that the number of IL-23p19 expressing macrophages was increased. Adalimumab was administered, and his back pain and abdominal symptoms improved. Adalimumab might be an effective treatment for gut inflammation related to ankylosing spondylitis.
authors.affiliation: a Department of Gastroenterology and Hematology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Ota
authors.affiliation: a Department of Gastroenterology and Hematology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.|b Department of Community Medicine , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
authors.forename: Hirotake
authors.initials: H
authors.lastname: Sakuraba
authors.affiliation: a Department of Gastroenterology and Hematology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.|c Department of Community Healthcare Development in Odate and North Akita , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Hiraga
authors.affiliation: a Department of Gastroenterology and Hematology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hasui
authors.affiliation: a Department of Gastroenterology and Hematology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
authors.forename: Miwa
authors.initials: M
authors.lastname: Satake
authors.affiliation: a Department of Gastroenterology and Hematology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Hanabata
authors.affiliation: a Department of Gastroenterology and Hematology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
authors.forename: Yui
authors.initials: Y
authors.lastname: Akemoto
authors.affiliation: a Department of Gastroenterology and Hematology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
authors.forename: Rina
authors.initials: R
authors.lastname: Watanabe
authors.affiliation: a Department of Gastroenterology and Hematology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
authors.forename: Nahoko
authors.initials: N
authors.lastname: Tanaka
authors.affiliation: d Division of Clinical Research , Hirosaki National Hospital, National Hospital Organization , Hirosaki , Japan.
authors.forename: Yoh
authors.initials: Y
authors.lastname: Ishiguro
authors.affiliation: e Department of Pathology and Laboratory Medicine , Hirosaki Municipal Hospital , Hirosaki , Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: a Department of Gastroenterology and Hematology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.|b Department of Community Medicine , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Fukuda
mesh_terms: D000068879:Adalimumab / Q000008:administration & dosage / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D053704:Capsule Endoscopy; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000188:drug therapy*; D008297:Male; D013167:Spondylitis, Ankylosing / Q000150:complications*; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D000068879:Adalimumab
keywords:  TNF-α inhibitor; Adalimumab; ankylosing spondylitis; capsule endoscopy; gut inflammation