title: Personalized plasma-based medicine to treat age-related diseases.
abstract: As social and health needs are changing, new challenges to develop innovative alternatives arise to address unmet medical needs. Personalized medicine is emerging as a promising and appealing therapeutic option. The use of patient's own plasma and platelets as therapeutics is providing new avenues in the treatment of acute and chronic tissue injuries by promoting tissue repair and regeneration. Plasma and platelet-based therapies mimic the physiological repair process by releasing autologous growth factors and creating a natural, biodegradable and transient scaffold that acts as transient matrix. This review summarizes the recent advances and challenges in the field of personalized plasma-based medicine and its potential to treat age-related diseases.
authors.affiliation: Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain; BTI-Biotechnology Institute, Vitoria, Spain. Electronic address: eduardoanitua@eduardoanoitua.com.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Anitua
authors.affiliation: BTI-Biotechnology Institute, Vitoria, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Troya
authors.affiliation: BTI-Biotechnology Institute, Vitoria, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Zalduendo
authors.affiliation: Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain; NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country, School of Pharmacy, Vitoria, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain. Electronic address: gorka.orive@bti-implant.es.
authors.forename: Gorka
authors.initials: G
authors.lastname: Orive
mesh_terms: D015352:Dry Eye Syndromes / Q000473:pathology / Q000628:therapy; D005337:Fibrin / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000378:metabolism; D053657:Platelet-Rich Plasma / Q000737:chemistry* / Q000378:metabolism; D057285:Precision Medicine; D012038:Regeneration / Q000502:physiology; D013705:Temporomandibular Joint Disorders / Q000473:pathology / Q000628:therapy; D052256:Tendinopathy / Q000473:pathology / Q000628:therapy; D014182:Transplantation, Autologous
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D005337:Fibrin
keywords: Autologous therapies; Growth factors; Personalized medicine; Platelet rich plasma; Scaffold; Tissue regeneration