title: Delivery of curcumin by a pH-responsive chitosan mesoporous silica nanoparticles for cancer treatment.
abstract: Mesoporous silica nanocarriers as accommodate drug molecule capsules were synthesized and capped by chitosan natural polymer. This nanocarrier acts as a pH-responsive shield to increase the solubility and improvement of anticancer properties of curcumin against U87MG glioblastoma cancer cell line. The encapsulation efficiency and drug-loading content were measured 88.1 ± 4.76% and 8.81 ± 0.47%, respectively. The curcumin release from the CS-MCM-41 was slow and sustained at low pH (42.72 ± 2.29%) compared to the environment pH (19.54 ± 1.36%) in 96 h. The MTT evaluations showed that IC50after 72 h treatment with free curcumin and curcumin-loaded CS-MCM-41 were 15.20 and 5.21 μg/mL (p <0.05). respectively.
authors.affiliation: a Department of Biotechnology , University Campus 2, University of Guilan , Rasht , Iran.
authors.forename: Navid
authors.initials: N
authors.lastname: Ahmadi Nasab
authors.affiliation: b Faculty of Agricultural Sciences , University of Guilan , Rasht , Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Hassani Kumleh
authors.affiliation: c Materials and Energy Research Center , Tehran , Iran.
authors.forename: Mojtaba
authors.identifier: http://orcid.org/0000-0002-0949-9915
authors.initials: M
authors.lastname: Beygzadeh
authors.affiliation: d Department of Medical genetics , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Shahram
authors.initials: S
authors.lastname: Teimourian
authors.affiliation: c Materials and Energy Research Center , Tehran , Iran.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Kazemzad
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; C509968:MCM-41; D012822:Silicon Dioxide; D048271:Chitosan; D003474:Curcumin
keywords: Mesoporous silica; cancer therapy; chitosan; drug delivery; nanomedicine; pH sensitive