title: p120-catenin in canonical Wnt signaling.
abstract: Canonical Wnt signaling controls β-catenin protein stabilization, its translocation to the nucleus and the activation of β-catenin/Tcf-4-dependent transcription. In this review, we revise and discuss the recent results describing actions of p120-catenin in different phases of this pathway. More specifically, we comment its involvement in four different steps: (i) the very early activation of CK1ɛ, essential for Dvl-2 binding to the Wnt receptor complex; (ii) the internalization of GSK3 and Axin into multivesicular bodies, necessary for a complete stabilization of β-catenin; (iii) the activation of Rac1 small GTPase, required for β-catenin translocation to the nucleus; and (iv) the release of the inhibitory action caused by Kaiso transcriptional repressor. We integrate these new results with the previously known action of other elements in this pathway, giving a particular relevance to the responses of the Wnt pathway not required for β-catenin stabilization but for β-catenin transcriptional activity. Moreover, we discuss the possible future implications, suggesting that the two cellular compartments where β-catenin is localized, thus, the adherens junction complex and the Wnt signalosome, are more physically connected that previously thought.
authors.affiliation: a Departament de Bioquímica i Biologia Molecular, CEB, Facultat de Medicina , Universitat Autònoma de Barcelona , Bellaterra , Spain.
authors.forename: Mireia
authors.initials: M
authors.lastname: Duñach
authors.affiliation: a Departament de Bioquímica i Biologia Molecular, CEB, Facultat de Medicina , Universitat Autònoma de Barcelona , Bellaterra , Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Del Valle-Pérez
authors.affiliation: b Programa de Recerca en Càncer , Institut Hospital del Mar d'Investigacions Mèdiques (IMIM) , Barcelona , Spain.|c Departament de Ciències Experimentals i de la Salut , Universitat Pompeu Fabra , Barcelona , Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: García de Herreros
mesh_terms: D000818:Animals; D051177:Catenins / Q000378:metabolism*; D000072261:Dishevelled Proteins / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism; D006801:Humans; D060490:Receptors, Wnt / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic / Q000502:physiology*; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000378:metabolism; D020744:rac GTP-Binding Proteins / Q000378:metabolism; D000095002:Delta Catenin
chemical_list: D051177:Catenins; C000606581:DVL2 protein, human; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; C090146:Rac1 protein, Drosophila; D060490:Receptors, Wnt; D014157:Transcription Factors; C492254:ZBTB33 protein, human; D051176:beta Catenin; D020744:rac GTP-Binding Proteins; D000095002:Delta Catenin; C000722347:CTNND1 protein, human
keywords: CK1ɛ; Kaiso; Rac1; Wnt signaling; p120-catenin; β-catenin