title: Six new furostanol glycosides from Smilax glauco-china and their cytotoxic activity.
abstract: Six new steroidal saponins, namely glauco-chinaosides A-F, and one known compound were isolated from the tubers of Smilax glauco-china. Their structures were elucidated by a combination of spectroscopic analysis and hydrolysis followed by spectral and chromatographic analysis. Compounds 1-7 were tested in vitro for their cytotoxic activities against four human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, and Lovo). Compounds 1, 2, and 5 exhibited cytotoxic activity against SGC-7901, with IC50values of 2.7, 11.5, and 6.8 μM, respectively.
authors.affiliation: a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liang
authors.affiliation: a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Pan
authors.affiliation: b Gastroenterology Department , Jiangxi Province People Hospital , Nanchang 330006 , China.
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
authors.forename: Gen-Hua
authors.initials: GH
authors.lastname: Zhu
authors.affiliation: a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
authors.forename: Hui-Lian
authors.initials: HL
authors.lastname: Huang
authors.affiliation: a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
authors.forename: Ji-Cheng
authors.initials: JC
authors.lastname: Shu
authors.affiliation: a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Shao
authors.affiliation: a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Liang
authors.affiliation: a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
authors.forename: Jiang-Li
authors.initials: JL
authors.lastname: Yu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045325:HCT116 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032281:Smilax / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D012503:Saponins; D013261:Sterols; C574436:furostanol glycoside
keywords: Smilacaceae; Smilax glauco-china; cytotoxic activity; furostanol glycosides