title: Meteorological factors on the incidence of MP and RSV pneumonia in children.
abstract: BACKGROUND
  Pneumonia is common in children and mostly caused by many pathogens. The aim of this study was to investigate whether the incidence of pediatric mycoplasma pneumoniae (MP) pneumonia and respiratory syncytial virus (RSV) pneumonia was associated with meteorological factors in Hangzhou, China.
  
  
  METHODS
  A total of 36500 pneumonia patients were recruited to participate in the study. Nasopharyngeal swabs were collected for the detection of MP and RSV using real-time polymerase chain reaction (RT-PCR) and direct immunofluorescence (DIF) assays, respectively. We used a distributed lag non-linear model (DLNM) to evaluate the correlations between the MP/RSV incidence and meteorological factors.
  
  
  RESULTS
  The detection rates of MP and RSV were 18.4% and 10.4%, respectively. There was a positive correlation between temperature and the MP infection rate, but RSV infection rate was negatively associated with temperature. Moreover, the impact of temperature on infection with RSV presented evident lag and cumulative effects. There was also an evident lag effect of temperature on the infection rate of MP; however, there was no evident cumulative effect.
  
  
  CONCLUSIONS
  In this study, the results showed meteorological factors play an important role in the incidence of these two pathogens. All these results can provide the laboratory basis for the early diagnosis and treatment of pneumonia in children.
authors.affiliation: Clinical Laboratory, The Children´s Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Tian
authors.affiliation: Clinical Laboratory, The Children´s Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Jiang
authors.affiliation: Clinical Laboratory, The Children´s Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Chen
authors.affiliation: Clinical Laboratory, The Children´s Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
mesh_terms: D002648:Child; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D009177:Mycoplasma pneumoniae / Q000235:genetics / Q000302:isolation & purification; D011019:Pneumonia, Mycoplasma / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D018357:Respiratory Syncytial Virus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000235:genetics / Q000302:isolation & purification; D012621:Seasons; D013696:Temperature
chemical_list: D004269:DNA, Bacterial; D012367:RNA, Viral