title: Lack of association between MTHFR A1298C variant and Alzheimer's disease: evidence from a systematic review and cumulative meta-analysis.
abstract: OBJECTIVE
  Previous studies have investigated the association between MTHFR A1298C (rs1801131) polymorphism and susceptibility to Alzheimer's disease (AD). Nevertheless, an ultimate conclusion remains obscure. We then executed this meta-analysis to estimate this association more precisely.
  
  
  METHODS
  Related studies were systematically searched on PubMed, Embase, China National Knowledge Infrastructure, Google scholar, and AlzGene databases. The association was evaluated by reviewing the odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Publication bias, sensitivity analysis, and cumulative meta-analysis were performed to help draw a more definite conclusion.
  
  
  RESULTS
  Ten eligible studies were finally enrolled in this meta-analysis. Lack of association between MTHFR A1298C polymorphism and AD risk was observed in five genetic models (allelic: OR = 1.17, 95% CI: 0.88-1.56; homozygous: OR = 1.15, 95% CI: 0.87-1.53; heterozygous: OR = 1.19, 95% CI: 0.76-1.86; dominant: OR = 1.23, 95% CI: 0.81-1.87; recessive: OR = 1.16, 95% CI: 0.89-1.52). The result of cumulative meta-analysis sorted by publication year was also detected a dynamic tendency of no correlation between MTHFR A1298C polymorphism and AD.
  
  
  CONCLUSIONS
  This meta-analysis reveals that MTHFR A1298C polymorphism may not be associated with AD risk.
authors.affiliation: a China-America Cancer Research Institute , Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University , Dongguan , China.|b Department of Pathophysiology , Guangdong Medical University , Dongguan , China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Liu
authors.affiliation: c Department of Pharmacy , Yuebei People's Hospital , Shaoguan , China.
authors.forename: Yongfu
authors.initials: Y
authors.lastname: Wu
authors.affiliation: d The Second School of Clinical Medicine , Guangdong Medical University , Dongguan , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.affiliation: a China-America Cancer Research Institute , Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University , Dongguan , China.|b Department of Pathophysiology , Guangdong Medical University , Dongguan , China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Zhou
authors.affiliation: a China-America Cancer Research Institute , Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University , Dongguan , China.|b Department of Pathophysiology , Guangdong Medical University , Dongguan , China.
authors.forename: Ziyou
authors.initials: Z
authors.lastname: Wang
authors.affiliation: a China-America Cancer Research Institute , Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University , Dongguan , China.|b Department of Pathophysiology , Guangdong Medical University , Dongguan , China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: He
authors.affiliation: a China-America Cancer Research Institute , Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University , Dongguan , China.|b Department of Pathophysiology , Guangdong Medical University , Dongguan , China.
authors.forename: Zunnan
authors.initials: Z
authors.lastname: Huang
mesh_terms: D000409:Alanine / Q000235:genetics; D000544:Alzheimer Disease / Q000235:genetics*; D003545:Cysteine / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2); D003545:Cysteine; D000409:Alanine
keywords: A1298C (rs1801131) polymorphism; Alzheimer’s disease; Methylene-tetrahydrofolate reductase (MTHFR); meta-analysis