title: Origami microfluidic paper-analytical-devices (omPAD) for sensing and diagnostics.
abstract: Recent research activities in the area of low-cost sensing and diagnostics that are realized on cellulosic paper substrate are presented. First a three-dimensional origami paper-based analytical device (omPAD) with multiple electrochemical sensors, an integrated sample reservoir and tight integration with a custom CMOS potentiostat is presented. Second, an optical sensor array with built-in microfluidic channel for sample delivery is presented. The sensors are fabricated using a combination of wax printing and screen-printing using a solution based approach in ambient conditions without the need for expensive fabrication equipment or a cleanroom. Readout is based on using existing consumer grade electronic devices like flatbed scanner (for optical sensor) or custom designed CMOS potentiostat (for electrochemical sensors). Together the 3D paper-based analytical device with integrated sensor, microfluidics and portable readout instrumentation demonstrates a low-cost, self-contained system suitable for sensing and point-of-care diagnostics.
authors.forename: Meera
authors.initials: M
authors.lastname: Punjiya
authors.lastname: Chung Hee Moon
authors.lastname: Yu Chen
authors.forename: Sameer
authors.initials: S
authors.lastname: Sonkusale
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D004298:Dopamine / Q000032:analysis; D055664:Electrochemical Techniques / Q000295:instrumentation; D004566:Electrodes; D021621:Imaging, Three-Dimensional; D008670:Metals / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D055616:Microtechnology; D055620:Optical Phenomena; D010087:Oxides / Q000737:chemistry; D010209:Paper; D019095:Point-of-Care Systems; D012666:Semiconductors
chemical_list: D008670:Metals; D010087:Oxides; D004298:Dopamine