title: Computed tomography findings in Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) of the elderly: comparison with EBV-negative DLBCL.
abstract: OBJECTIVE
  This study aimed to compare CT findings in patients with Epstein-Barr virus positive (EBV+) diffuse large B-cell lymphoma (DLBCL) of the elderly with CT findings in patients with Epstein-Barr virus negative (EBV-) DLBCL.
  
  
  METHODS
  We retrospectively identified 9 consecutive patients with EBV+ DLBCL (6 males and 3 females; aged 72-83 years, mean: 76.2 years) and 39 consecutive patients with EBV- DLBCL (19 males and 20 females; aged 53-91 years, mean: 71.3 years) who had undergone CT examinations between September 2007 and August 2016. In each type of disease, clinical and CT findings were evaluated.
  
  
  RESULTS
  No significant differences in B symptom incidence or serum lactate dehydrogenase levels were found between the two diseases. However, the prognosis of patients with EBV+ DLBCL was significantly poorer than that of those with EBV- DLBCL (p < 0.05). Nodal and extranodal necrosis was found in 6 (66.7%) of 9 patients with EBV+ DLBCL and in 6 (15.4%) of 39 patients with EBV- DLBCL (p < 0.005).
  
  
  CONCLUSIONS
  The CT finding of nodal and extranodal necrosis was significantly more frequent in patients with EBV+ DLBCL than in patients with EBV- DLBCL. Advances in knowledge: This is the first report on the CT findings in patients with EBV+ DLBCL of the elderly. Different CT findings are present in EBV+ DLBCL and EBV- DLBCL.
authors.affiliation: 1 Department of Radiology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Kouhei
authors.initials: K
authors.lastname: Tokuyama
authors.affiliation: 1 Department of Radiology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Fumito
authors.initials: F
authors.lastname: Okada
authors.affiliation: 1 Department of Radiology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Sato
authors.affiliation: 1 Department of Radiology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Shunro
authors.initials: S
authors.lastname: Matsumoto
authors.affiliation: 1 Department of Radiology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumoto
authors.affiliation: 1 Department of Radiology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Haruno
authors.affiliation: 2 Department of Clinical Laboratory, Oita Prefectural Hospital, Oita, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kashima
authors.affiliation: 3 Department of Medical Oncology and Hematology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Ogata
authors.affiliation: 4 Department of Hematology, Oita Prefectural Hospital, Oita, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ohtsuka
authors.affiliation: 1 Department of Radiology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Hiromu
authors.initials: H
authors.lastname: Mori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*