title: [Use of pharmacogenetic testing to prevent adverse drug reactions during statin therapy].
abstract: The number of patients receiving statins increases every year and due to the fact that they should take statins during their lives, the problem of their safety use comes to the forefront. The paper analyzes the safety of using the medications of this group and discusses the diagnosis of myopathies induced by statins and the occurrence of immune-mediated statin myopathies. It considers a personalized approach to prescribing statins, analyzes Russian and foreign experience in using pharmacogenetics to reduce the risk of myopathies, publishes the results of the authors' experience in clinically introducing pharmacogenetic testing at hospitals, and analyzes the long-term results of determining the polymorphism of the SLCO1B1 gene for the prediction of the risk of adverse events when using statins and estimating patient compliance to prescribed treatment.
authors.affiliation: I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia; Research Center for Examination of Medical Products, Ministry of Health of Russia, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Rumyantsev
authors.affiliation: I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia; Research Center for Examination of Medical Products, Ministry of Health of Russia, Moscow, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Kukes
authors.affiliation: Research Center for Examination of Medical Products, Ministry of Health of Russia, Moscow, Russia.
authors.forename: R E
authors.initials: RE
authors.lastname: Kazakov
authors.affiliation: N.N. Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Rumyantsev
authors.affiliation: Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia, Moscow, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Sychev
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics / Q000517:prevention & control; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D027381:Liver-Specific Organic Anion Transporter 1 / Q000235:genetics*; D009135:Muscular Diseases / Q000139:chemically induced / Q000235:genetics / Q000517:prevention & control; D000071185:Pharmacogenomic Testing / Q000379:methods*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D027381:Liver-Specific Organic Anion Transporter 1; C503999:SLCO1B1 protein, human