title: Copper-catalyzed Direct 2-Arylation of Benzoxazoles and Benzoimidazoles with Aryl Bromides and Cytotoxicity of Products.
abstract: An efficient copper-catalyzed direct 2-arylation of benzoxazoles and benzoimidazoles with aryl bromides is presented. The CuI/PPh3-based catalyst promotes the installation of various aryl and heteroaryl groups through a C-H activation process in good to excellent yields. The cytotoxicity of obtained 2-aryl benzoxazoles (benzoimidazoles) was also evaluated and 1-methyl-2-(naphthalen-1-yl)benzoimidazole showed potential cytotoxicity.
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China.|Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
authors.forename: Nan-Nan
authors.initials: NN
authors.lastname: Jia
authors.affiliation: Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
authors.forename: Xin-Chuan
authors.initials: XC
authors.lastname: Tian
authors.affiliation: Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Qu
authors.affiliation: Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
authors.forename: Xing-Xiu
authors.initials: XX
authors.lastname: Chen
authors.affiliation: Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Cao
authors.affiliation: Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
authors.forename: Yun-Xin
authors.initials: YX
authors.lastname: Yao
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China.|Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China.
authors.forename: Xian-Li
authors.initials: XL
authors.lastname: Zhou
mesh_terms: D001554:Benzene / Q000737:chemistry*; D001583:Benzoxazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008956:Models, Chemical; D015394:Molecular Structure
chemical_list: D001583:Benzoxazoles; D001965:Bromides; D007093:Imidazoles; D003300:Copper; D001554:Benzene