title: Long non-coding RNA CASC2 in human cancer.
abstract: Long non-coding RNAs cover large part of the non-coding information of the human DNA, which represents more than 90% of the whole genome. They constitute a wide and complex group of molecules with more than 200 nucleotides, which generally lack an open reading frame, and are involved in various ways in the pathophysiology of cancer. Their roles in the regulation of gene expression, imprinting, transcription, and post-translational processing have been described in several types of cancer. CASC2 was discovered in 2004 in patients with endometrial carcinoma as a potential tumor suppressor. Since then, additional studies in other types of neoplasia have been carried out, and both mechanisms and interactions of CASC2 in cancer have been better elucidated. In this review, we summarize the current knowledge on the role of CASC2 in the genesis, progression, and clinical management of human cancer.
authors.affiliation: Unit of Cancer Genetics, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Traversa La Crucca 3, 07100, Sassari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Palmieri
authors.affiliation: Department of Clinical and Experimental Medicine, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy. Electronic address: panospaliogiannis@gmail.com.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Paliogiannis
authors.affiliation: Unit of Cancer Genetics, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Traversa La Crucca 3, 07100, Sassari, Italy.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Sini
authors.affiliation: Unit of Cancer Genetics, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Traversa La Crucca 3, 07100, Sassari, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Manca
authors.affiliation: Unit of Cancer Genetics, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Traversa La Crucca 3, 07100, Sassari, Italy.
authors.forename: Grazia
authors.initials: G
authors.lastname: Palomba
authors.affiliation: Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Viale San Pietro 43B, 07100, Sassari, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Doneddu
authors.affiliation: Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Viale San Pietro 43B, 07100, Sassari, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Tanda
authors.affiliation: Department of Clinical and Experimental Medicine, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Pascale
authors.affiliation: Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Viale San Pietro 43B, 07100, Sassari, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cossu
mesh_terms: D000818:Animals; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding; D025521:Tumor Suppressor Proteins; C484713:long non-coding RNA CASC2, human
keywords: CASC2; Cancer; Oncogenesis; Oncosuppressor; lncRNA