title: Clinical Response of Tedizolid versus Linezolid in Acute Bacterial Skin and Skin Structure Infections by Severity Measure Using a Pooled Analysis from Two Phase 3 Double-Blind Trials.
abstract: Tedizolid phosphate is approved for the treatment of acute bacterial skin and skin structure infections (ABSSSI). In a pooled analysis of 1,333 ABSSSI patients from the ESTABLISH clinical trials, treatment with tedizolid or linezolid demonstrated similar early and posttherapy clinical responses in nonsevere and severe disease, irrespective of the parameters used to measure ABSSSI severity. Shorter 6-day treatment of ABSSSI, including those that were severe, with tedizolid phosphate demonstrated efficacy comparable to that of 10-day treatment with linezolid. (The ESTABLISH studies discussed in this paper have been registered at ClinicalTrials.gov under identifiers NCT01170221 and NCT01421511.).
authors.affiliation: Merck & Co., Inc., Kenilworth, New Jersey, USA.
authors.forename: Taylor
authors.initials: T
authors.lastname: Sandison
authors.affiliation: Merck & Co., Inc., Kenilworth, New Jersey, USA carisa.de.anda@merck.com.
authors.forename: Carisa
authors.initials: C
authors.lastname: De Anda
authors.affiliation: Merck & Co., Inc., Kenilworth, New Jersey, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: Fang
authors.affiliation: InClin, San Mateo, California, USA.
authors.forename: Anita F
authors.initials: AF
authors.lastname: Das
authors.affiliation: Merck & Co., Inc., Kenilworth, New Jersey, USA.
authors.forename: Philippe
authors.initials: P
authors.lastname: Prokocimer
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D000069349:Linezolid / Q000627:therapeutic use*; D010755:Organophosphates / Q000627:therapeutic use*; D010080:Oxazoles / Q000627:therapeutic use*; D012867:Skin / Q000382:microbiology / Q000473:pathology; D017192:Skin Diseases, Bacterial / Q000188:drug therapy*; D013207:Staphylococcal Skin Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects; D013290:Streptococcal Infections / Q000188:drug therapy*; D013297:Streptococcus pyogenes / Q000187:drug effects; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D010755:Organophosphates; D010080:Oxazoles; D000069349:Linezolid; C515040:tedizolid phosphate
keywords: ABSSSI; clinical response; linezolid; severity; tedizolid phosphate