title: Modelling nutrient transfer based on 3D imaging of the human placental microstructure.
abstract: Impaired transfer of nutrients from mother to fetus can affect pregnancy outcomes. The placenta has a complex microstructure, including the maternal intervillous space and fetal capillaries. Previous computational models of placental transfer either assumed a simplified idealized local geometry or were based on 2D imaging. In this study, we present a novel 3D computational model to assess the placental transfer of nutrients at the microscale in interaction with the maternal flow environment. A stack of confocal microscopy images of the placental terminal villi was collected and reconstructed. The 3D simulation framework was tested for the transport of oxygen. Preliminary results identified local stagnant zones, as well as areas of high nutrient transfer into the fetal capillaries in the most exposed branches of the villi as a result of better perfusion, combined with a smaller thickness of the tissue barrier. Overall, the current model may serve as a tool for assessing pregnancy conditions affected by inefficient nutrient transfer due to altered microscale placental morphology.
authors.forename: S
authors.initials: S
authors.lastname: Perazzolo
authors.forename: R M
authors.initials: RM
authors.lastname: Lewis
authors.forename: B G
authors.initials: BG
authors.lastname: Sengers
mesh_terms: D001692:Biological Transport; D002196:Capillaries / Q000648:ultrastructure; D002824:Chorionic Villi / Q000648:ultrastructure*; D005260:Female; D005333:Fetus / Q000098:blood supply; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D010100:Oxygen / Q000378:metabolism; D010920:Placenta / Q000378:metabolism / Q000648:ultrastructure*; D011247:Pregnancy
chemical_list: D010100:Oxygen