title: Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years.
abstract: OBJECTIVE
  We aimed to investigate the association of serum uric acid (UA) levels with bone mineral density (BMD) at all skeletal sites in healthy Chinese males >50 years of age.
  
  
  METHODS
  A cross-sectional study of 385 Chinese males >50 years of age who underwent health checkup in Huadong Hospital Affiliated to Fudan University in Shanghai, China, was conducted. Clinical and bone characteristics were compared in different UA tertiles (UA1: UA <4.7 mg/dL, UA2: 4.7 mg/dL ≤ UA <6 mg/dL and UA3: UA ≥6 mg/dL). Pearson correlation and multiple regression analysis were used to study the correlation of UA with BMD at various skeletal sites.
  
  
  RESULTS
  Serum UA levels were positively associated with higher BMD and T-values at the lumbar spine, but not at other skeletal sites, after adjusting for multiple confounding factors. Lumbar spine BMD; the T- and Z-values at the lumbar spine, total hip and femoral neck; as well as intact parathyroid hormone (iPTH) levels are higher in the highest tertile of UA than in the second tertile of UA.
  
  
  CONCLUSIONS
  Our results provide epidemiological evidence in Chinese Han males aged >50 years that serum UA levels are positively correlated with lumbar spine BMD and T-values, suggesting that UA may exert protective effect on bone density at the lumbar spine in Chinese males >50 years of age.
authors.affiliation: Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
authors.forename: Xinhui
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
authors.forename: Wenyi
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
authors.forename: Zhenxing
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Ye
mesh_terms: D000368:Aged; D044466:Asian People; D001823:Body Composition; D015519:Bone Density / Q000502:physiology*; D002681:China; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005272:Femur Neck; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D010384:Pelvic Bones; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: T-value; Z-value; bone turnover marker; parathyroid hormone