title: Imaging of Prostate Cancer Using Fluciclovine.
abstract: Prostate cancer is the most common cancer and the second leading cause of cancer death in men in the United States. Despite high disease prevalence, diagnosis and surveillance of the disease with conventional imaging are limited typically because of indolent biology. Functional imaging with advanced molecular techniques improves the ability to detect disease. Amino acids are building blocks of proteins, and intracellular transport of amino acids is upregulated in prostate cancer. This review provides a detailed overview of the use of F-18 fluciclovine PET in prostate cancer imaging.
authors.affiliation: Department of Radiology, Loyola University Medical Center, 2160 South 1st Avenue, Maywood, IL 60153, USA. Electronic address: bital.savir-baruch@lumc.edu.
authors.forename: Bital
authors.initials: B
authors.lastname: Savir-Baruch
authors.affiliation: Department of Nuclear Medicine, Policlinico Sant'Orsola-Malpighi, Azienda Ospedaliero-Universitaria di Bologna, via Massarenti 9, Bologna 40138, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Zanoni
authors.affiliation: Department of Radiology and Imaging Sciences, Emory University Hospital, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Schuster
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D002264:Carboxylic Acids; D003503:Cyclobutanes; D017277:Drug Approval; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008207:Lymphatic Metastasis; D008297:Male; D064847:Multimodal Imaging / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods; D011182:Postoperative Care; D017410:Practice Guidelines as Topic; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D002264:Carboxylic Acids; D003503:Cyclobutanes; D019275:Radiopharmaceuticals; C117460:fluciclovine F-18
keywords: Axumin; CT; FACBC; Fluciclovine; PET; Prostate