title: Effects of Jasminum multiflorum leaf extract on rodent models of epilepsy, motor coordination and anxiety.
abstract: Jasmine flowers and leaves are used extensively in folk medicine in different parts of the world to treat a variety of diseases. However, there are very few published reports on the neuropsychiatric effects of Jasmine extracts. Hence, the objectives of the present study were to examine the effects of an alcohol extract of Jasminum multiflorum leaves on topically-applied bicuculline (a model of acute simple partial epilepsy) and maximal electroshock (MES, a model of generalized tonic-clonic seizure) in male Sprague-Dawley rats. The objectives also included an examination of the anxiolytic properties of the extract using an elevated plus maze and the effect of the extract on motor coordination using a rotarod treadmill. Phytochemical analysis of the extract showed the presence of three flavonoids and four additional compounds belonging to the steroid, terpenoid, phenol or sugar classes of compounds. The Jasmine alcohol extract, diluted with water and given orally or intraperitoneally, reduced the number of bicuculline-induced epileptiform discharges in a dose-dependent manner. The extract did not cause a significant increase in the current needed to induce hind limb extension in MES experiments. The extract significantly affected motor coordination when injected at 500mg/kg but not at 200mg/kg. At the latter dose, the extract increased open-arm entries and duration in the elevated plus maze to a level comparable to that of diazepam at 2mg/kg. We conclude that Jasmine leaf extract has a beneficial effect against an animal model of acute partial complex epilepsy, and significant anxiolytic effect at a dose that does not affect motor co-ordination.
authors.affiliation: Department of Preclinical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago. Electronic address: jonas.addae@sta.uwi.edu.
authors.forename: Jonas I
authors.initials: JI
authors.lastname: Addae
authors.affiliation: Department of Chemistry, University of the West Indies, St. Augustine, Trinidad and Tobago.
authors.forename: Ramish
authors.initials: R
authors.lastname: Pingal
authors.affiliation: Department of Preclinical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago.
authors.forename: Kheston
authors.initials: K
authors.lastname: Walkins
authors.affiliation: Department of Preclinical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago.
authors.forename: Renee
authors.initials: R
authors.lastname: Cruickshank
authors.affiliation: Department of Preclinical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago.
authors.forename: Farid F
authors.initials: FF
authors.lastname: Youssef
authors.affiliation: Department of Preclinical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago.
authors.forename: Shivananda B
authors.initials: SB
authors.lastname: Nayak
mesh_terms: D000818:Animals; D001007:Anxiety / Q000188:drug therapy* / Q000503:physiopathology; D000069280:Electrocorticography / Q000187:drug effects / Q000379:methods; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D031660:Jasminum; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D018515:Plant Leaves; D011597:Psychomotor Performance / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts
keywords: Anxiolytic; Epilepsy; Flavonoids; Jasmine; Motor coordination; Seizures