title: Platelet activation by ADP is increased in selected patients with anterior ischemic optic neuropathy or retinal vein occlusion.
abstract: To investigate whether adenosine diphosphate (ADP)-induced platelet hyperaggregability is associated with nonarteritic anterior ischemic optic neuropathy (NAION) or retinal vein occlusion (RVO). We retrospectively reviewed thrombophilia screening data of patients with NAION or RVO without a history of arterial hypertension, diabetes mellitus, hyperlipidemia, obesity, and cigarette abuse. Patients with a positive family history for thromboembolism were not excluded. Platelet aggregation (area under the curve, AUC) after induction of 0.5, 1.0, and 2.0 µmol of ADP was estimated in 25 NAION and RVO patients and compared with 25 healthy controls. We observed significantly greater platelet aggregation post 0.5 (P = 0.002) and 1.0 (P = 0.008) µmol of ADP among NAION and RVO patients compared with healthy controls. Platelet hyperaggregability was significantly more prevalent in patients than in controls (56% vs. 8%; P = 0.0006). Our results suggest that in NAION and RVO patients without a history of arterial hypertension, diabetes mellitus, hyperlipidemia, obesity, and cigarette abuse, platelets are significantly hyperreactive after induction of very low concentrations of ADP when compared with healthy individuals. This hyperreactivity is particularly evident in patients with a family history of thromboembolism.
authors.affiliation: a Department of Ophthalmology , Goethe University Hospital, Frankfurt am Main , Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Kuhli-Hattenbach
authors.affiliation: b Institute of Hemostaseology and Transfusion Medicine , Ludwigshafen Hospital, Ludwigshafen am Rhein , Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Hellstern
authors.affiliation: a Department of Ophthalmology , Goethe University Hospital, Frankfurt am Main , Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kohnen
authors.affiliation: c Department of Ophthalmology , Ludwigshafen Hospital, Ludwigshafen am Rhein , Germany.
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Hattenbach
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000328:Adult; D000867:Anterior Chamber / Q000098:blood supply / Q000294:innervation / Q000378:metabolism; D019540:Area Under Curve; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018917:Optic Neuropathy, Ischemic / Q000097:blood* / Q000473:pathology; D010974:Platelet Aggregation / Q000187:drug effects*; D010979:Platelet Function Tests; D012170:Retinal Vein Occlusion / Q000097:blood* / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood* / Q000473:pathology
chemical_list: D000244:Adenosine Diphosphate
keywords: Adenosine diphosphate; nonarteritic anterior ischemic optic neuropathy; platelet aggregation; platelet hyperreactivity; retinal vein occlusion