title: Continuous membrane potential fluctuations in motor cortex and striatum neurons during voluntary forelimb movements and pauses.
abstract: Theoretical simulations suggest that spike rate is regulated by varying both membrane potential and its fluctuation. We investigated whether membrane potential fluctuation functionally changes in motor cortex and striatum neurons during discrete forelimb movements and pauses, or at rest, using whole-cell recording in task-performing rats. Membrane potential fluctuation was diminished by task performance, but maintained overall in the alpha/beta and gamma bands during forelimb movements and pauses. By contrast, membrane potential itself was correlated with spike rate in task-related neurons. Thus, membrane potential, but not its fluctuation, is a critical determinant of execution and pausing of discrete movements.
authors.affiliation: Brain Science Institute/Graduate School of Brain Sciences, Tamagawa University, 6-1-1 Tamagawagakuen, Machida, Tokyo 194-8610, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nonomura
authors.affiliation: Brain Science Institute/Graduate School of Brain Sciences, Tamagawa University, 6-1-1 Tamagawagakuen, Machida, Tokyo 194-8610, Japan; Laboratory of Neural Circuitry, Graduate School of Brain Science, Doshisha University, 1-3 Tatara Miyakodai, Kyotanabe, Kyoto 610-0394, Japan; CREST, Japan Science and Technology Agency, 7 Gobancho, Chiyodaku, Tokyo 102-0076, Japan; Faculty of Human Life Studies, Department of Food and Nutrition, Hagoromo University of International Studies, 1-89-1 Hamadera Minamimachi, Nishiku, Sakai, Osaka 592-8344, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fujiwara-Tsukamoto
authors.affiliation: Brain Science Institute/Graduate School of Brain Sciences, Tamagawa University, 6-1-1 Tamagawagakuen, Machida, Tokyo 194-8610, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kajihara
authors.affiliation: Laboratory of Neural Circuitry, Graduate School of Brain Science, Doshisha University, 1-3 Tatara Miyakodai, Kyotanabe, Kyoto 610-0394, Japan.
authors.forename: Fumino
authors.initials: F
authors.lastname: Fujiyama
authors.affiliation: Brain Science Institute/Graduate School of Brain Sciences, Tamagawa University, 6-1-1 Tamagawagakuen, Machida, Tokyo 194-8610, Japan; CREST, Japan Science and Technology Agency, 7 Gobancho, Chiyodaku, Tokyo 102-0076, Japan. Electronic address: isomura@lab.tamagawa.ac.jp.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Isomura
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D005552:Forelimb; D008297:Male; D008564:Membrane Potentials; D009043:Motor Activity; D009044:Motor Cortex / Q000502:physiology*; D020318:Rats, Long-Evans
keywords: Forelimb movement; Motor cortex; Rat; Striatum; Whole-cell recording