title: Risk Factor Analysis of Graft Failure With Concomitant Cyst Enucleation of the Jaw Bone: A Retrospective Multicenter Study.
abstract: OBJECTIVE
  Cysts are common pathologic entities in the oral and maxillofacial region. Enucleation is commonly used for treatment and is occasionally followed by bone grafting. However, no studies have evaluated factors affecting the failure of grafts used for cystic defects in the oral and maxillofacial region. Therefore, the present study was conducted to determine the risk factors for postoperative graft failure in patients treated with cyst enucleation and simultaneous bone grafting.
  
  
  METHODS
  Clinical data for 305 patients who had undergone cyst enucleation with simultaneous bone grafting were retrospectively investigated in this multicenter case-and-control study. The predictor variables included host, pathologic, and treatment factors. The outcome variable was success or failure of the bone graft. Descriptive statistics were computed, and the P value was set at .05.
  
  
  RESULTS
  Bone graft failure was observed in 48 cases. The mean duration from surgery to failure was 38.7 days. Multivariable logistic regression analysis showed a significant association between graft failure and younger age (odds ratio [OR] = 1.033; P = .016), smoking (OR = 2.598; P = .017), preoperative infection (OR = 4.660; P = .001), large cysts (OR = 1.052; P = .010), impaction of the mandibular third molar in the cystic cavity (OR = 3.021; P = .007), perilesional osteosclerosis (OR = 4.973; P = .001), and the use of mixed non-autogenous and autogenous bone grafts (OR = 3.891; P = .007).
  
  
  CONCLUSIONS
  This study provides a list of important factors that should be considered by clinicians planning enucleation and simultaneous bone grafting for cysts in the oral and maxillofacial region.
authors.affiliation: Clinical Instructor, Department of Oral and Maxillofacial Surgery, Korea University Medical Center, Guro Hospital, Seoul, Korea.
authors.forename: Ho-Kyung
authors.initials: HK
authors.lastname: Lim
authors.affiliation: Clinical Assistant Professor, Department of Oral and Maxillofacial Surgery, Ewha Womans University Medical Center, Seoul, Korea.
authors.forename: Jin-Woo
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Assistant Professor, Department of Oral and Maxillofacial Surgery, Chung-Ang University Hospital, Seoul, Korea.
authors.forename: Ui-Lyong
authors.initials: UL
authors.lastname: Lee
authors.affiliation: Clinical Fellow, Department of Oral and Maxillofacial Surgery, Hallym University Sacred Heart Hospital, Seoul, Korea.
authors.forename: Ju-Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Clinical Professor, Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea. Electronic address: neo0224@gmail.com.
authors.forename: Ho
authors.initials: H
authors.lastname: Lee
mesh_terms: D000328:Adult; D000367:Age Factors; D001424:Bacterial Infections / Q000209:etiology; D016025:Bone Transplantation; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D007571:Jaw Diseases / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009807:Odontogenic Cysts / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology*; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D013223:Statistics as Topic