title: [Heterodimeric D1-D2 dopamine receptors: a review].
abstract: This review summarizes modern data on the structure and functions ofheteromersformed by D1 and D2 dopamine receptors focusing on their role in the mechanisms of drug dependence. This article discusses potential functional significance of heterodimeric D1-D2 dopamine receptorsdue to their localization in the brain as well as unique pharmacological propertiesversus constituent monomers. It is shown that heteromerization results in dramatic changes in activated signaling pathways compare to the corresponding monomers. These studies update our current knowledge of ligand-receptor interactions and provide better understanding of dopamine receptors pharmacology. Furthermore elucidation of significance of heterodimeric D1-D2 dopamine receptors as drug targets is important for the development of new effective drug addiction treatment.
authors.affiliation: V.P. Serbsky Federal Medical Research Center on Psychiatry and Narcology, Moscow, Russia.
authors.forename: N L
authors.initials: NL
authors.lastname: Vekshina
authors.affiliation: V.P. Serbsky Federal Medical Research Center on Psychiatry and Narcology, Moscow, Russia.
authors.forename: P K
authors.initials: PK
authors.lastname: Anokhin
authors.affiliation: V.P. Serbsky Federal Medical Research Center on Psychiatry and Narcology, Moscow, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Veretinskaya
authors.affiliation: V.P. Serbsky Federal Medical Research Center on Psychiatry and Narcology, Moscow, Russia.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Shamakina
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000235:genetics / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology*; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D009294:Narcotics / Q000494:pharmacology*; D055503:Protein Multimerization; D017447:Receptors, Dopamine D1 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D019966:Substance-Related Disorders / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D015259:Dopamine Agents; D009294:Narcotics; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; C579455:BDNF protein, human; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D043802:GTP-Binding Protein alpha Subunits, Gq-G11; D004298:Dopamine
keywords: dopamine receptors; drug dependence; heteromers; mesolimbic system; psychoactive substances