title: Localized MRI and histological image correlation in a canine model of duchenne muscular dystrophy.
abstract: Duchenne Muscular Dystrophy (DMD) is a fatal X-linked disorder. Therapeutic assessments currently require muscle biopsy to ascertain information about the status of disease progression. MRI shows potential to be used in place of muscle biopsy for therapeutic assessments. In this work, localized histological data and various MRI parameters were correlated in a canine model of DMD. The results indicate several MRI parameters may be useful as biomarkers of disease progression.
authors.forename: A
authors.initials: A
authors.lastname: Eresen
authors.forename: S
authors.initials: S
authors.lastname: McConnell
authors.forename: S M
authors.initials: SM
authors.lastname: Birch
authors.forename: J F
authors.initials: JF
authors.lastname: Griffin
authors.forename: J N
authors.initials: JN
authors.lastname: Kornegay
authors.forename: J X
authors.initials: JX
authors.lastname: Ji
mesh_terms: D000818:Animals; D015415:Biomarkers; D018450:Disease Progression; D004285:Dogs; D006651:Histocytochemistry / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging* / Q000473:pathology; D020388:Muscular Dystrophy, Duchenne / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D015415:Biomarkers