title: Phenylpropanoids from the fruits of Nicandra physaloides and their anti-inflammatory activities.
abstract: Twenty-one phenylpropanoids, including 1 new (1) and 20 known phenylpropanoids (2-21), were isolated and identified from the fruits of Nicandra physaloides. The structures of these compounds were established by 1D and 2D NMR spectra referring to the literatures, together with mass spectrometry. It was found that the isolated compounds, except for 7, 18 and 19, showed the different levels of inhibitions on NO production by LPS-induced RAW 264.7 cells at IC50values from 27.0 to 97.3 μM.
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , People's Republic of China.
authors.forename: Bing You
authors.initials: BY
authors.lastname: Yang
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , People's Republic of China.
authors.forename: Hai Bing
authors.initials: HB
authors.lastname: Jiang
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , People's Republic of China.
authors.forename: Zhen Peng
authors.initials: ZP
authors.lastname: Xu
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Guo
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , People's Republic of China.
authors.forename: Xiao Mao
authors.initials: XM
authors.lastname: Li
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , People's Republic of China.
authors.forename: Hai Xue
authors.initials: HX
authors.lastname: Kuang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005638:Fruit / Q000737:chemistry; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D020005:Propanols / Q000737:chemistry* / Q000494:pharmacology; D000067996:RAW 264.7 Cells; D019657:Solanaceae / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D020005:Propanols; D009569:Nitric Oxide
keywords: RAW 264.7; Solanaceae; coumarin; lignans; structure–activity relationships