title: Patterns of failure after brain metastases radiotherapy: reflections on the importance for treatment and clinical trials reporting.
abstract: In many ongoing clinical trials, new strategies for radiotherapy of brain metastases are currently being investigated. A post surgical focal cavity stereotactic radiosurgery and the developing role of a hippocampal-sparing whole brain radiotherapy are of the highest importance. The evaluation of spatial patterns of metastases failure after radiotherapy is a powerful tool for assessing the potential benefit of new different radiotherapy approaches, which enables to identify possible directions leading to better radiotherapy techniques and to modify general management for newly diagnosed brain metastases. The purpose of this article is to present a mix between trial data and philosophical point of view for discussion about the importance of systematic evaluation of spatial patterns of failure in all ongoing trials investigating new approaches in local brain metastases treatment.
authors.forename: R
authors.initials: R
authors.lastname: Lakomy
authors.forename: L
authors.initials: L
authors.lastname: Hynkova
authors.forename: P
authors.initials: P
authors.lastname: Pospisil
authors.forename: P
authors.initials: P
authors.lastname: Burkon
authors.forename: M
authors.initials: M
authors.lastname: Slavik
authors.forename: P
authors.initials: P
authors.lastname: Slampa
authors.forename: R
authors.initials: R
authors.lastname: Jancalek
authors.forename: T
authors.initials: T
authors.lastname: Kazda
mesh_terms: D001932:Brain Neoplasms / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D006801:Humans; D009362:Neoplasm Metastasis / Q000175:diagnosis; D016634:Radiosurgery; D017211:Treatment Failure
keywords: brain recurrence; progression; stereotactic radiosurgery; whole brain radiotherapy hippocampal sparing radiotherapy.