title: Thienopyrimidine-type compounds protect Arabidopsis plants against the hemibiotrophic fungal pathogen Colletotrichum higginsianum and bacterial pathogen Pseudomonas syringae pv. maculicola.
abstract: Plant activators activate systemic acquired resistance-like defense responses or induced systemic resistance, and thus protect plants from pathogens. We screened a chemical library composed of structurally diverse small molecules. We isolated six plant immune-inducing thienopyrimidine-type compounds and their analogous compounds. It was observed that the core structure of thienopyrimidine plays a role in induced resistance in plants. Furthermore, we highlight the protective effect of thienopyrimidine-type compounds against both hemibiotrophic fungal pathogen, Colletotrichum higginsianum, and bacterial pathogen, Pseudomonas syringae pv. maculicola, in Arabidopsis thaliana. We suggest that thienopyrimidine-type compounds could be potential lead compounds as novel plant activators, and can be useful and effective agrochemicals against various plant diseases.
authors.affiliation: a Research Institute for Biological Sciences Okayama , Okayama , Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Narusaka
authors.affiliation: a Research Institute for Biological Sciences Okayama , Okayama , Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Narusaka
mesh_terms: D017360:Arabidopsis / Q000187:drug effects / Q000382:microbiology*; D029681:Arabidopsis Proteins / Q000378:metabolism; D020231:Colletotrichum / Q000187:drug effects / Q000472:pathogenicity*; D044224:Pseudomonas syringae / Q000187:drug effects / Q000472:pathogenicity*; D011743:Pyrimidines / Q000494:pharmacology*; D020156:Salicylic Acid / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D011743:Pyrimidines; C476003:thienopyrimidine; D020156:Salicylic Acid
keywords: Arabidopsis; Colletotrichum higginsianum; PR-1 gene; Pseudomonas syringae; plant activator; salicylic acid; thienopyrimidine