title: Synthetic nanocarriers for the delivery of polynucleotides to the eye.
abstract: This review is a comprehensive analysis of the progress made so far on the delivery of polynucleotide-based therapeutics to the eye, using synthetic nanocarriers. Attention has been addressed to the capacity of different nanocarriers for the specific delivery of polynucleotides to both, the anterior and posterior segments of the eye, with emphasis on their ability to (i) improve the transport of polynucleotides across the different eye barriers; (ii) promote their intracellular penetration into the target cells; (iii) protect them against degradation and, (iv) deliver them in a long-term fashion way. Overall, the conclusion is that despite the advantages that nanotechnology may offer to the area of ocular polynucleotide-based therapies (especially AS-ODN and siRNA delivery), the knowledge disclosed so far is still limited. This fact underlines the necessity of more fundamental and product-oriented research for making the way of the said nanotherapies towards clinical translation.
authors.affiliation: Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Av. Barcelona s/n, Campus Vida, Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors.forename: Sofia M
authors.initials: SM
authors.lastname: Saraiva
authors.affiliation: Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Av. Barcelona s/n, Campus Vida, Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Castro-López
authors.affiliation: Sylentis, R&D Department, c/Santiago Grisolía 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Covadonga
authors.initials: C
authors.lastname: Pañeda
authors.affiliation: Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Av. Barcelona s/n, Campus Vida, Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain; Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. Electronic address: mariaj.alonso@usc.es.
authors.forename: María José
authors.initials: MJ
authors.lastname: Alonso
mesh_terms: D060433:Administration, Ophthalmic; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D005128:Eye Diseases / Q000235:genetics / Q000628:therapy*; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D058449:Intravitreal Injections; D053758:Nanoparticles / Q000737:chemistry*; D016376:Oligonucleotides, Antisense / Q000008:administration & dosage / Q000737:chemistry; D010316:Particle Size; D011119:Polynucleotides / Q000008:administration & dosage* / Q000737:chemistry; D034741:RNA, Small Interfering / Q000008:administration & dosage; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D016376:Oligonucleotides, Antisense; D011119:Polynucleotides; D034741:RNA, Small Interfering
keywords: Anterior segment; Eye; Nanocarriers; Ocular polynucleotide delivery; Polynucleotides; Posterior segment