title: Exercising Restraint.
abstract: Ten years ago, while in Paul Bieniasz's group, I determined that an interferon-induced antiviral activity inhibited the release of enveloped viruses by tethering them to the plasma membrane of infected cells. This commentary examines the lead up to this study and how our observations led to the identification of tetherin.
authors.affiliation: Department of Infectious Disease, Faculty of Life Science and Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK. Electronic address: stuart.neil@kcl.ac.uk.
authors.forename: Stuart J D
authors.initials: SJ
authors.lastname: Neil
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D016086:Lentivirus / Q000276:immunology* / Q000502:physiology*; D011323:Primates; D057074:Virus Release