title: Antibacterial Nerol Cinnamates from the Australian Plant Eremophila longifolia.
abstract: Two new antimicrobial agents, neryl ferulate (1) and neryl p-coumarate (2), were identified using bioassay-guided isolation from the leaves of Eremophila longifolia, which is a medicinal plant used by some Australian Aboriginal communities. Although gradual autoxidation of the nerol subunit hindered the initial attempts to purify and characterize 1 and 2, it was found that the autoxidation could be stopped through storage under argon at -20 °C. Biological evaluation showed that neryl ferulate (1) had moderate activity against various Gram-positive bacteria, while neryl p-coumarate (2) was active only against Enterococcus faecium.
authors.affiliation: Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology , Hawthorn 3122, Victoria, Australia.
authors.forename: Savithri
authors.initials: S
authors.lastname: Galappathie
authors.affiliation: Institute for Molecular Bioscience, University of Queensland , St Lucia 4072, Queensland, Australia.
authors.forename: David J
authors.initials: DJ
authors.lastname: Edwards
authors.affiliation: Institute for Molecular Bioscience, University of Queensland , St Lucia 4072, Queensland, Australia.
authors.forename: Alysha G
authors.initials: AG
authors.lastname: Elliott
authors.affiliation: Institute for Molecular Bioscience, University of Queensland , St Lucia 4072, Queensland, Australia.
authors.forename: Matthew A
authors.identifier: 0000-0003-3147-3460
authors.initials: MA
authors.lastname: Cooper
authors.affiliation: Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology , Hawthorn 3122, Victoria, Australia.
authors.forename: Enzo A
authors.initials: EA
authors.lastname: Palombo
authors.affiliation: Institute for Molecular Bioscience, University of Queensland , St Lucia 4072, Queensland, Australia.
authors.forename: Mark S
authors.identifier: 0000-0001-6689-4236
authors.initials: MS
authors.lastname: Butler
authors.affiliation: Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology , Hawthorn 3122, Victoria, Australia.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Mahon
mesh_terms: D000080462:Acyclic Monoterpenes; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001315:Australia; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D041621:Eremophila Plant / Q000737:chemistry*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000080462:Acyclic Monoterpenes; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002934:Cinnamates; D003373:Coumaric Acids; D013729:Terpenes; C007836:geraniol