title: Adults with common variable immunodeficiency: a single-center experience.
abstract: In this study, we aimed to assess the clinical and immunological findings of our patients with common variable immunodeficiency (CVID).
  
  
  
  We analyzed the records of 31 adult patients with CVID (12 females, 19 males). The patients were classified into clinical and immunophenotypic subgroups for statistical comparisons.
  
  
  
  Our patients had some clinical signs in considerable frequencies, such as low body weight (45.2%), urinary tract infections (41.9%), various dermatoses (35.5%), and oral aphthae (32.3%). The histological findings in the biopsy specimens of the gastrointestinal tract (nodular lymphoid hyperplasia, villous atrophy, and lymphocytic infiltrates at mucosa) were significantly associated with splenomegaly, hepatomegaly, or low body weight (P = 0.005, 0.045, and 0.007, respectively). The patients with low CD4/CD8 ratios had lower IgG levels and a lower percentage of CD19+ B cells, but a higher percentage of activated T cells (P = 0.023, 0.011, and 0.028, respectively).
  
  
  
  In adults with CVID, there existed some clinical signs at considerable frequencies, but these are not overemphasized in the literature. The CD4/CD8 ratio is an important factor in antibody production and the clinical presentation of CVID. It seems that the adaptive immune system is on alert and subclinical immune activation insidiously continues in patients with CVID.
authors.affiliation: Division of Immunology and Allergic Diseases, Lösante Hospital, Ankara, Turkey.
authors.forename: Uğur Haci
authors.initials: UH
authors.lastname: Muşabak
authors.affiliation: Division of Immunology and Allergic Diseases, Gülhane Training and Research Hospital, Ankara, Turkey.
authors.forename: Fevzi
authors.initials: F
authors.lastname: Demirel
authors.affiliation: Division of Immunology and Allergic Diseases, Gülhane Training and Research Hospital, Ankara, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Yeşillik
authors.affiliation: Division of Immunology and Allergic Diseases, Sultan Abdulhamid Han Training and Research Hospital, İstanbul, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Baysan
authors.affiliation: Division of Immunology and Allergic Diseases, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Selçuk
authors.affiliation: Division of Immunology and Allergic Diseases, Gülhane Training and Research Hospital, Health Sciences University, Ankara, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Kartal
authors.affiliation: Division of Immunology and Allergic Diseases, Güven Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Güleç
authors.affiliation: Department of Internal Medicine, Anadolu Medical Center, Kocaeli, Turkey.
authors.forename: Çağatay
authors.initials: Ç
authors.lastname: Öktenli
authors.affiliation: Division of Immunology and Allergic Diseases, Gülhane Training and Research Hospital, Health Sciences University, Ankara, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Şener
mesh_terms: D000328:Adult; D016516:CD4-CD8 Ratio; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D016130:Immunophenotyping; D008297:Male; D012189:Retrospective Studies; D013851:Thinness
chemical_list: D007136:Immunoglobulins