title: TUSC3: a novel tumour suppressor gene and its functional implications.
abstract: The tumour suppressor candidate 3 (TUSC3) gene is located on chromosome region 8p22 and encodes the 34 kD TUSC3 protein, which is a subunit of the oligosaccharyl transferase responsible for the N-glycosylation of nascent proteins. Known to be related to autosomal recessive mental retardation for several years, TUSC3 has only recently been identified as a potential tumour suppressor gene. Based on the structure and function of TUSC3, specific mechanisms in various diseases have been investigated. Several studies have demonstrated that TUSC3 is an Mg2+-transporter involved in magnesium transport and homeostasis, which is important for learning and memory, embryonic development and testis maturation. Moreover, dysfunction or deletion of TUSC3 exerts its oncological effects as a modulator by inhibiting glycosylation efficiency and consequently inducing endoplasmic reticulum stress and malignant cell transformation. In this study, we summarize the advances in the studies of TUSC3 and comment on the potential roles of TUSC3 in diagnosis and treatment of TUSC3-related diseases, especially cancer.
authors.affiliation: Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
authors.forename: Xinshuang
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, China.
authors.forename: Chunjuan
authors.initials: C
authors.lastname: Zhai
authors.affiliation: Medical Management Service Center of Shandong Provincial Health and Family Planning Commission, Jinan, China.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
authors.forename: Jiandong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Liang
authors.affiliation: Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
authors.forename: Fengjun
authors.initials: F
authors.lastname: Liu
authors.affiliation: Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Cao
authors.affiliation: China Institute of Veterinary Drugs Control, Beijing, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.|Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Du
mesh_terms: D000818:Animals; D004194:Disease; D047108:Embryonic Development / Q000235:genetics; D044127:Epigenesis, Genetic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D009154:Mutation / Q000235:genetics
chemical_list: D008565:Membrane Proteins
keywords: N-glycosylation reaction; oligosaccharyl transferase; tumour suppressor candidate 3; tumourgenesis