title: Ruthenium(II) piano stool coordination compounds with aminomethylphosphanes: Synthesis, characterisation and preliminary biological study in vitro.
abstract: Reaction of {[Ru(η6-p-cymene)Cl]2(μ-Cl)2} (1) with aminomethylphosphane derived from morpholine (P{CH2N(CH2CH2)2O}3(A), PPh2{CH2N(CH2CH2)2O} (B)) or piperazine (P{CH2N(CH2CH2)2NCH2CH3}3(C), PPh2{CH2N(CH2CH2)2NCH2CH3} (D)) results in four new piano stool ruthenium(II) coordination compounds: [Ru(η6-p-cymene)Cl2(A)] (2A), [Ru(η6-p-cymene)Cl2(B)] (2B), [Ru(η6-p-cymene)Cl2(C)] (2C) and [Ru(η6-p-cymene)Cl2(D)] (2D). Every complex was fully characterized using spectroscopic methods (1H,13C{1H},31P{1H} NMR and ESI-MS), elemental analysis, X-ray single crystal diffraction and DFT calculations. Preliminary studies of in vitro cytotoxicity on the A549 (human lung adenocarcinoma) and MCF7 (human breast adenocarcinoma) cell lines revealed 2A-2D activity in the same order of magnitude as in the case of cisplatin. Additionally, the study confirmed the ability of 2A-2D to interact with DNA helix and transferrin.
authors.affiliation: Faculty of Chemistry, Jagiellonian University in Krakow, Ingardena 3, 30-060 Krakow, Poland; Faculty of Conservation and Restoration of Works of Art, Jan Matejko Academy of Fine Arts in Krakow, Lea 27-29, 30-052 Krakow, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Płotek
authors.affiliation: Faculty of Chemistry, University of Wroclaw, Joliot-Curie 14, 50-383 Wroclaw, Poland. Electronic address: radoslaw.starosta@chem.uni.wroc.pl.
authors.forename: Radosław
authors.initials: R
authors.lastname: Starosta
authors.affiliation: Faculty of Chemistry, University of Wroclaw, Joliot-Curie 14, 50-383 Wroclaw, Poland.
authors.forename: Urszula K
authors.initials: UK
authors.lastname: Komarnicka
authors.affiliation: Faculty of Chemistry, Jagiellonian University in Krakow, Ingardena 3, 30-060 Krakow, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Skórska-Stania
authors.affiliation: Faculty of Chemistry, Jagiellonian University in Krakow, Ingardena 3, 30-060 Krakow, Poland.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Kołoczek
authors.affiliation: Faculty of Chemistry, Jagiellonian University in Krakow, Ingardena 3, 30-060 Krakow, Poland. Electronic address: kyziol@chemia.uj.edu.pl.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kyzioł
mesh_terms: D000072283:A549 Cells; D002945:Cisplatin / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D061986:MCF-7 Cells; D012428:Ruthenium / Q000737:chemistry / Q000494:pharmacology
chemical_list: D056831:Coordination Complexes; D012428:Ruthenium; D002945:Cisplatin
keywords: Aminomethylphosphanes; Cytotoxicity; Organometallic chemistry; Ruthenium