title: The effect of glucagon-like peptide-1 and glucagon-like peptide-2 on microcirculation: A systematic review.
abstract: GLP-1 and GLP-2 are gut-derived hormones used in the treatment of diabetes type-2 and short bowel syndrome, respectively. GLP-1 attenuates insulin resistance and GLP-2 reduces enterocyte apoptosis and enhances crypt cell proliferation in the small intestine. In addition, both hormones have vasoactive effects and may be useful in situations with impaired microcirculation. The aim of this systematic review was to provide an overview of the potential effects of GLP-1 and GLP-2 on microcirculation. A systematic search was performed independently by two authors in the following databases: PubMed, EMBASE, Cochrane library, Scopus, and Web of Science. Of 1111 screened papers, 20 studies were included in this review: 16 studies in animals, three in humans, and one in humans and rats. The studies were few and heterogeneous and had a high risk of bias. However, it seems that GLP-1 regulates the pancreatic, skeletal, and cardiac muscle flow, indicating a role in the glucose homeostasis, while GLP-2 acts primarily in the regulation of the microcirculation of the mid-intestine. These findings may be useful in gastrointestinal surgery and in situations with impaired microcirculation of the gut.
authors.affiliation: Department of Surgical Gastroenterology, Rigshospitalet, Copenhagen University Hospital, Copenhagen Ø, Denmark.
authors.forename: Nikolaj
authors.identifier: 0000-0003-4066-2925
authors.initials: N
authors.lastname: Nerup
authors.affiliation: Department of Surgical Gastroenterology, Rigshospitalet, Copenhagen University Hospital, Copenhagen Ø, Denmark.
authors.forename: Rikard
authors.initials: R
authors.lastname: Ambrus
authors.affiliation: Department of Surgical Gastroenterology, Rigshospitalet, Copenhagen University Hospital, Copenhagen Ø, Denmark.
authors.forename: Joanna
authors.initials: J
authors.lastname: Lindhe
authors.affiliation: Department of Surgical Gastroenterology, Rigshospitalet, Copenhagen University Hospital, Copenhagen Ø, Denmark.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Achiam
authors.affiliation: Department of Medical Gastroenterology, Rigshospitalet, Copenhagen University Hospital, Copenhagen Ø, Denmark.
authors.forename: Palle B
authors.initials: PB
authors.lastname: Jeppesen
authors.affiliation: Department of Surgical Gastroenterology, Rigshospitalet, Copenhagen University Hospital, Copenhagen Ø, Denmark.
authors.forename: Lars B
authors.initials: LB
authors.lastname: Svendsen
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology; D052216:Glucagon-Like Peptide 1 / Q000627:therapeutic use*; D053767:Glucagon-Like Peptide 2 / Q000627:therapeutic use*; D006801:Humans; D007333:Insulin Resistance; D008833:Microcirculation / Q000187:drug effects*; D051381:Rats
chemical_list: D053767:Glucagon-Like Peptide 2; D052216:Glucagon-Like Peptide 1
keywords: glucagon-like peptide-1; glucagon-like peptide-2; microcirculation; systematic review