title: Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders.
abstract: Several studies have linked the high intake of lycopene or tomatoes products with lower risk for metabolic diseases. The aim of the present study was to evaluate and to compare the effect of lycopene and tomato powder on obesity-associated disorders.
  
  
  
  Male C57BL/J6 mice were assigned into four groups to receive: control diet (CD), high fat diet (HFD), high fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks. In HFD condition, lycopene and TP supplementation significantly reduced adiposity index, organ, and relative organ weights, serum triglycerides, free fatty acids, 8-iso-prostaglandin GF2α and improved glucose homeostasis, but did not affect total body weight. Lycopene and TP supplementation prevented HFD-induced hepatosteatosis and hypertrophy of adipocytes. Lycopene and TP decreased HFD-induced proinflammatory cytokine mRNA expression in the liver and in the epididymal adipose tissue. The anti-inflammatory effect of lycopene and TP was related to a reduction in the phosphorylation levels of IκB, and p65, and resulted in a decrease of inflammatory proteins in adipose tissue.
  
  
  
  These results suggest that lycopene or TP supplementation display similar beneficial health effects that could be particularly relevant in the context of nutritional approaches to fight obesity-associated pathologies.
authors.affiliation: NORT, Aix-Marseille Université, INRA, INSERM, Marseille, France.|LPNSA, Département de Biologie, Faculté des Sciences de la Nature et de la Vie, Université d'Oran 1 Ahmed Benbella, Oran, Algérie.
authors.forename: Soumia
authors.initials: S
authors.lastname: Fenni
authors.affiliation: LPNSA, Département de Biologie, Faculté des Sciences de la Nature et de la Vie, Université d'Oran 1 Ahmed Benbella, Oran, Algérie.
authors.forename: Habib
authors.initials: H
authors.lastname: Hammou
authors.affiliation: NORT, Aix-Marseille Université, INRA, INSERM, Marseille, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Astier
authors.affiliation: NORT, Aix-Marseille Université, INRA, INSERM, Marseille, France.
authors.forename: Lauriane
authors.initials: L
authors.lastname: Bonnet
authors.affiliation: NORT, Aix-Marseille Université, INRA, INSERM, Marseille, France.
authors.forename: Esma
authors.initials: E
authors.lastname: Karkeni
authors.affiliation: NORT, Aix-Marseille Université, INRA, INSERM, Marseille, France.
authors.forename: Charlène
authors.initials: C
authors.lastname: Couturier
authors.affiliation: NORT, Aix-Marseille Université, INRA, INSERM, Marseille, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Tourniaire
authors.affiliation: NORT, Aix-Marseille Université, INRA, INSERM, Marseille, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Landrier
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001823:Body Composition / Q000187:drug effects; D002338:Carotenoids / Q000494:pharmacology*; D059305:Diet, High-Fat; D019587:Dietary Supplements; D050356:Lipid Metabolism; D000077276:Lycopene; D018551:Solanum lycopersicum; D008297:Male; D008659:Metabolic Diseases / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000502:physiology; D009765:Obesity / Q000517:prevention & control*
chemical_list: D000893:Anti-Inflammatory Agents; D016328:NF-kappa B; D002338:Carotenoids; D000077276:Lycopene
keywords: Adipose tissue carotenoids; Inflammation; Insulin sensitivity; Metabolic disease; Obesity; Tomato product; steatosis