title: The role of chemotherapy in gastric cancer-related microangiopathic haemolytic anaemia.
abstract: We report a case of a previously well 46-year-old man who presented with microangiopathic haemolytic anaemia (MAHA) of unknown origin. After extensive investigations, he was diagnosed with cancer-related microangiopathic haemolytic anaemia (CR-MAHA) secondary to gastric adenocarcinoma. Initial treatment with plasmapheresis was ineffective, but the patient's haematological abnormalities improved markedly with chemotherapy directed against his gastric cancer. Our case amplifies previous experience of gastric cancer-associated MAHA which responded to treatment with chemotherapy. We review current understanding of the proposed pathophysiology of CR-MAHA and conclude that this condition is ideally treated with chemotherapy.
authors.affiliation: Prince of Wales Hospital Clinical School, University of New South Wales, Sydney NSW, Australia.
authors.forename: Monica
authors.initials: M
authors.lastname: Tang
authors.affiliation: Prince of Wales Hospital Clinical School, University of New South Wales, Sydney NSW, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Goldstein
keywords: Thrombotic microangiopathies; anemia; drug therapy; hemolytic; stomach neoplasms; thrombocytopenia