title: Canonical Transient Receptor Potential Channels and Their Link with Cardio/Cerebro-Vascular Diseases.
abstract: The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of Ca2+selectivity. TRPCs consist of seven mammalian members, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7, which are further divided into four subtypes, TRPC1, TRPC2, TRPC4/5, and TRPC3/6/7. These channels take charge of various essential cell functions such as contraction, relaxation, proliferation, and dysfunction. This review, organized into seven main sections, will provide an overview of current knowledge about the underlying pathogenesis of TRPCs in cardio/cerebrovascular diseases, including hypertension, pulmonary arterial hypertension, cardiac hypertrophy, atherosclerosis, arrhythmia, and cerebrovascular ischemia reperfusion injury. Collectively, TRPCs could become a group of drug targets with important physiological functions for the therapy of human cardio/cerebro-vascular diseases.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.|Cadet Brigade, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Hui-Xia
authors.initials: HX
authors.lastname: Liu
authors.affiliation: Cadet Brigade, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Kuo
authors.initials: K
authors.lastname: Shen
authors.affiliation: Department of Natural Medicine & Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Li
keywords: Ca2+ signaling; Canonical transient receptor potential receptor; Cardiovascular disease; Cerebrovascular disease; Pathogenesis