title: Cyclodextrin-gated mesoporous silica nanoparticles as drug carriers for red light-induced drug release.
abstract: Long wavelength light-responsive drug delivery systems based on mesoporous silica nanoparticles (MSNs) have attracted much attention in the last few years. In this paper, a red light (660 nm)-responsive drug delivery system based on low-cost cyclodextrin (CD)-gated MSNs containing a photodynamic therapy (PDT) photosensitizer (Chlorin e6, Ce6) was developed for the first time. The drug release experiment in water demonstrated that with the irradiation of red light, Ce6 can be excited to generate singlet oxygen, which can further cleave the singlet oxygen sensitive linker to trigger the departure of CD and the release of cargo. Further in vitro release experiments confirmed that cargo can be released from MSNs with the irradiation of red light and spread into the entire cell. The relative low power density (0.5 W cm-2) of excitation light together with the short irradiation time (one-three min) result in a low light dose (30-90 J cm-2) for the drug delivery, contributing to their potential clinical applications.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, People's Republic of China.
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Chai
authors.forename: Yu
authors.initials: Y
authors.lastname: Guo
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Chai
authors.forename: Yurong
authors.initials: Y
authors.lastname: Ma
authors.forename: Limin
authors.initials: L
authors.lastname: Qi
mesh_terms: D045744:Cell Line, Tumor; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008027:Light; D053758:Nanoparticles / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry
chemical_list: D003505:Cyclodextrins; D004337:Drug Carriers; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D012822:Silicon Dioxide