title: Diastolic dysfunction in hypertension.
abstract: Hypertension and coronary heart disease, often coexisting, are the most common risk factors for heart failure. The progression of hypertensive heart disease involves myocardial fibrosis and alterations in the left ventricular geometry that precede the functional change, initially asymptomatic. The left ventricular diastolic dysfunction is part of this continuum being defined by the presence of left ventricular diastolic dysfunction without signs or symptoms of heart failure or poor left ventricular systolic function. It is highly prevalent in hypertensive patients and is associated with increased cardiovascular morbidity and mortality. Despite its growing importance in clinical practice it remains poorly understood. This review aims to present the epidemiological fundamentals and the latest developments in the pathophysiology, diagnosis and treatment of left ventricular diastolic dysfunction.
authors.affiliation: Unidade Funcional Medicina 2, Hospital São José, Centro Hospitalar Lisboa Central - EPE, Lisboa, Portugal; Nova Medical School, Lisboa, Portugal. Electronic address: rodrigoromaoleao@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Nazário Leão
authors.affiliation: Nova Medical School, Lisboa, Portugal; Núcleo de Investigação Arterial, Unidade Funcional Medicina 4, Hospital Santa Marta, Centro Hospitalar Lisboa Central - EPE, Lisboa, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Marques da Silva
keywords: Diastolic dysfunction; Disfunción diastólica; Enfermedad cardíaca hipertensiva; Geometría ventricular izquierda; Heart failure with preserved ejection fraction; Hipertensión; Hypertension; Hypertensive heart disease; Insuficiencia cardíaca con fracción de eyección preservada; Left Ventricular geometry