title: Are Brazilian cervids at risk of prion diseases?
abstract: Prion diseases are neurodegenerative fatal disorders that affect human and non-human mammals. Chronic Wasting Disease (CWD) is a prion disease of cervids regarded as a public health problem in North America, and polymorphisms at specific codons in the PRNP gene are associated with this disease. To assess the potential CWD susceptibility of South American free-ranging deer, the presence of these polymorphisms was examined in Mazama gouazoubira, Ozotoceros bezoarticus and Blastocerus dichotomus. Despite the lack of CWD reports in Brazil, the examined codons (95, 96, 116, 132, 225, and 226) of the PRNP gene showed potential CWD susceptibility in Brazilian deer. Low abundancy of deer in Brazil possibly difficult both CWD proliferation and detection, however, CWD surveillance may not be neglected.
authors.affiliation: a Centro Acadêmico de Vitória, Universidade Federal de Pernambuco , Vitória de Santo Antão , PE , Brazil.
authors.forename: Caio Bruno Ribeiro
authors.initials: CB
authors.lastname: Falcão
authors.affiliation: a Centro Acadêmico de Vitória, Universidade Federal de Pernambuco , Vitória de Santo Antão , PE , Brazil.
authors.forename: Isabel Luiza de Melo Nunes Freire
authors.initials: IL
authors.lastname: Lima
authors.affiliation: b Departamento de Zootecnia , Universidade Estadual Paulista , São Paulo , Brazil.
authors.forename: José Maurício Barbanti
authors.initials: JM
authors.lastname: Duarte
authors.affiliation: c Departamento de Neuropsiquiatria , Universidade Federal de Pernambuco , Recife , PE , Brazil.
authors.forename: João Ricardo Mendes
authors.initials: JR
authors.lastname: de Oliveira
authors.affiliation: d Departamento de Zoologia , Universidade Federal de Pernambuco , Recife , PE , Brazil.
authors.forename: Rodrigo Augusto
authors.initials: RA
authors.lastname: Torres
authors.affiliation: a Centro Acadêmico de Vitória, Universidade Federal de Pernambuco , Vitória de Santo Antão , PE , Brazil.
authors.forename: Artur Maia
authors.initials: AM
authors.lastname: Wanderley
authors.affiliation: c Departamento de Neuropsiquiatria , Universidade Federal de Pernambuco , Recife , PE , Brazil.
authors.forename: José Eriton
authors.initials: JE
authors.lastname: Gomes da Cunha
authors.affiliation: a Centro Acadêmico de Vitória, Universidade Federal de Pernambuco , Vitória de Santo Antão , PE , Brazil.
authors.forename: José Eduardo
authors.initials: JE
authors.lastname: Garcia
mesh_terms: D000818:Animals; D001938:Brazil / Q000453:epidemiology; D003670:Deer; D017096:Prion Diseases / Q000453:epidemiology*
keywords: Blastocerus; Mazama; Ozotocerus; PrP; chronic wasting disease; neotropical deer; prion