title: Metal-Organic Synthetic Transporters (MOST): Efficient Chloride and Antibiotic Transmembrane Transporters.
abstract: We present the synthesis of two functionalized 2,4,7-triphenylbenzimidazole ligands and demonstrate the formation of their respective metal assemblies in phospholipid membranes. Anion transport experiments demonstrate the formation of metal-organic synthetic transporters (MOST) directly in phospholipid membranes. The formation of MOST in phospholipid membranes results in efficient architectures for chloride transport. We also demonstrate the insertion of these ligands and the formation of their metal-organic assemblies in bacterial membranes; the use of MOST makes the membranes of resistant bacteria more permeable to antibiotics. We also demonstrate that a combination of MOST with tetracycline lowers the sensitivity of resistant bacteria to tetracycline by 60-fold.
authors.affiliation: Département de Chimie, Université de Montréal, C. P. 6128 Succursale Centre-Ville, Montréal, Québec, H3C 3J7, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Kempf
authors.affiliation: Département de Chimie, Université de Montréal, C. P. 6128 Succursale Centre-Ville, Montréal, Québec, H3C 3J7, Canada.
authors.forename: Andreea R
authors.initials: AR
authors.lastname: Schmitzer
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001413:Bacillus thuringiensis / Q000187:drug effects; D002712:Chlorides / Q000737:chemistry / Q000378:metabolism*; D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism; D000073396:Metal-Organic Frameworks / Q000138:chemical synthesis / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010165:Palladium / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry; D013053:Spectrophotometry; D013752:Tetracycline / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002712:Chlorides; D056831:Coordination Complexes; D008081:Liposomes; D000073396:Metal-Organic Frameworks; D010743:Phospholipids; D010165:Palladium; D013752:Tetracycline
keywords: anions; antibacterial; membranes; metal-organic assemblies; transmembrane transport