title: Thioether-derived Macrocycle for Peptide Secondary Structure Fixation.
abstract: Recently, we developed methods to stabilize peptides into various secondary structures, including α-helix, type III turn and β-hairpin via proper thioether based macrocyclization. These conformationally constrained peptidomimetics confer enhanced biophysical properties and provide a valuable avenue towards clinically-relevant therapeutic molecules. In this personal account, thioether-derived macrocyclization methods developed by our group for stabilization of α-helix, type-III β turn and β-hairpin conformations are discussed.
authors.affiliation: School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, 518055, P. R. China.|School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 611756, P. R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.affiliation: School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, 518055, P. R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Gynecology, Second Clinical Medical College, Jinan University, Shenzhen People's Hospital, 1017 Dongmen North Road, Luohu District, Shenzhen, 518020, P. R. China.
authors.forename: Xiyang
authors.initials: X
authors.lastname: Ye
authors.affiliation: School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, 518055, P. R. China.
authors.forename: Zigang
authors.initials: Z
authors.lastname: Li
mesh_terms: D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D055550:Protein Stability; D017433:Protein Structure, Secondary; D013440:Sulfides / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D004987:Ethers; D010455:Peptides; D013440:Sulfides
keywords: constrained peptides; protein-protein interaction; type III β turn; α-helix; β-hairpin