title: Construction of Fluorinated Benzoxathiin Skeleton by Successive Perfluorophenylthiolation/Cyclization of Activated α-Methylene Ketones by Perfluorophenyl Diethylaminosulfur Difluoride.
abstract: Pharmaceutically attractive fluorinated benzoxathiin (thiaflavan) skeleton 4 was directly constructed by the reaction of activated α-methylene ketones 1 such as β-keto esters, 1,3-diketone, and β-keto sulfones with a perfluorophenyl analogue of diethylaminosulfur trifluoride, C6F5-DAST, in high yields via successive perfluorophenylthiolation/cyclization reaction.
authors.affiliation: Department of Nanopharmaceutical Sciences & Department of Frontier Materials, Nagoya Institute of Technology , Gokiso, Showa-ku, Nagoya, 466-8555, Japan.
authors.forename: Ibrayim
authors.initials: I
authors.lastname: Saidalimu
authors.affiliation: Department of Nanopharmaceutical Sciences & Department of Frontier Materials, Nagoya Institute of Technology , Gokiso, Showa-ku, Nagoya, 466-8555, Japan.
authors.forename: Shugo
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Nanopharmaceutical Sciences & Department of Frontier Materials, Nagoya Institute of Technology , Gokiso, Showa-ku, Nagoya, 466-8555, Japan.
authors.forename: Jiandong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Nanopharmaceutical Sciences & Department of Frontier Materials, Nagoya Institute of Technology , Gokiso, Showa-ku, Nagoya, 466-8555, Japan.
authors.forename: Etsuko
authors.initials: E
authors.lastname: Tokunaga
authors.affiliation: Department of Nanopharmaceutical Sciences & Department of Frontier Materials, Nagoya Institute of Technology , Gokiso, Showa-ku, Nagoya, 466-8555, Japan.
authors.forename: Norio
authors.identifier: 0000-0002-3742-4064
authors.initials: N
authors.lastname: Shibata