title: Human T Cell Leukemia Virus Type 1 and Eye Diseases.
abstract: Human T cell leukemia virus type 1, also known as human T lymphotropic virus type 1 (HTLV-1), is a retrovirus that encodes a reverse transcriptase, which translates viral RNA into a DNA provirus that is integrated into the host genome. The virus was found to be a causative agent of adult T cell leukemia/lymphoma (ATL) in the early 1980s, and was also found to cause the neurological disorder tropical spastic paraparesis (TSP)/HTLV-1-associated myelopathy (HAM) and the inflammatory disorder HTLV-1 uveitis in the mid 1980s and early 1990s, respectively. This article reviews eye diseases caused by or related to HTLV-1: HTLV-1 uveitis, ocular and systemic complications of HTLV-1, keratoconjunctivitis sicca, interstitial keratitis, and ATL.
authors.affiliation: 1 Department of Ophthalmology, Tokyo Metropolitan Geriatrics Hospital , Tokyo, Japan .|2 Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo, Japan .
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Terada
authors.affiliation: 2 Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo, Japan .
authors.forename: Koju
authors.initials: K
authors.lastname: Kamoi
authors.affiliation: 3 Miyata Eye Hospital , Miyakonojo, Miyazaki, Japan .
authors.forename: Takashi
authors.initials: T
authors.lastname: Komizo
authors.affiliation: 3 Miyata Eye Hospital , Miyakonojo, Miyazaki, Japan .
authors.forename: Kazunori
authors.initials: K
authors.lastname: Miyata
authors.affiliation: 2 Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo, Japan .|3 Miyata Eye Hospital , Miyakonojo, Miyazaki, Japan .
authors.forename: Manabu
authors.initials: M
authors.lastname: Mochizuki
mesh_terms: D005128:Eye Diseases / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity*; D006801:Humans
keywords: adult T cell leukemia; complications; human T cell leukemia virus type 1 (HTLV-1); interstitial keratitis; keratoconjunctivitis sicca; uveitis