title: Therapeutic Implications of Superoxide Dismutase And Its Importance in Kinase Drug Discovery.
abstract: In recent years, several scientific investigations have reported the therapeutic implications of superoxide dismutase (SOD) against oxidative stress and -induced pathology in clinical and preclinical trials. Indeed, various kinase, molecular signaling and physiological process has altered by reactive oxygen species. In spite of the abundant available literature reports, patents, clinical trials and commercialized products, the therapeutic application of SOD as a potential drug still remains unclear. Owing to the technical challenges associated with the utilization of SOD as a drug, we revisited the structural arrangement and cellular signaling, significant association with kinase, exploring the new target sites and introducing new formulation strategies such as gene modulation, nano-formulations and click chemistry is a prerequisite. In-addition to gene modulation strategies, encapsulated formulation within a nano-carrier for producing promising SOD therapeutic effects, application of click chemistry including bioconjugation and cyclo-addition are the most prominent methods to produce highly efficient SOD formulations. Thus, the present review enlightens the foremost technique which may have better interaction with kinase and other cellular signaling for regulating the physiological process.
authors.affiliation: Amity Institute of Click Chemistry, Molecular Science and Engineering laboratory, Amity University, Sector-125, Noida-201303, Uttar Pradesh, India.
authors.forename: Nameet
authors.initials: N
authors.lastname: Kaur
authors.affiliation: Amity Institute of Pharmacy, Amity University, Sector-125, Noida-201303, Uttar Pradesh, India.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Sharma
authors.affiliation: Amity Institute of Biotechnology, Amity University, Sector-125, Noida-201303, Uttar Pradesh, India.
authors.forename: Adeeba
authors.initials: A
authors.lastname: Shakeel
authors.affiliation: Amity Institute of Click Chemistry, Molecular Science and Engineering laboratory, Amity University, Sector-125, Noida-201303, Uttar Pradesh, India.
authors.forename: Vipin
authors.initials: V
authors.lastname: Kumar
authors.affiliation: Amity Institute of Click Chemistry, Molecular Science and Engineering laboratory, Amity University, Sector-125, Noida-201303, Uttar Pradesh, India.
authors.forename: Aarti
authors.initials: A
authors.lastname: Singh
authors.affiliation: Amity Institute of Biotechnology, Amity University, Sector-125, Noida-201303, Uttar Pradesh, India.
authors.forename: Apoorv
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Amity Institute of Click Chemistry, Molecular Science and Engineering laboratory, Amity University, Sector-125, Noida-201303, Uttar Pradesh, India.
authors.forename: Deepa
authors.initials: D
authors.lastname: Suhag
authors.affiliation: Amity Institute of Pharmacy, Amity University, Sector-125, Noida-201303, Uttar Pradesh, India.
authors.forename: Satyendra K
authors.initials: SK
authors.lastname: Rajput
authors.affiliation: Amity Institute of Click Chemistry, Molecular Science and Engineering laboratory, Amity University, Sector-125, Noida-201303, Uttar Pradesh, India.|Amity Institute of Biotechnology, Amity University, Sector-125, Noida-201303, Uttar Pradesh, India.
authors.forename: Monalisa
authors.initials: M
authors.lastname: Mukherjee
mesh_terms: D000818:Animals; D055808:Drug Discovery; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D047428:Protein Kinase Inhibitors; D013482:Superoxide Dismutase; D011494:Protein Kinases
keywords: Superoxide dismutase; click chemistry; gene modulation; kinase; nano-formulation; oxidative stress