title: Assessing the Accuracy of the Modified Chinese Autism Spectrum Rating Scale and Social Responsiveness Scale for Screening Autism Spectrum Disorder in Chinese Children.
abstract: The reported prevalence of autism spectrum disorder (ASD) has been increasing rapidly in many parts of the world. However, data on its prevalence in China are largely missing. Here, we assessed the suitability of the modified Chinese version of a newly-developed ASD screening tool, the Modified Chinese Autism Spectrum Rating Scales (MC-ASRS) in screening for ASD in Chinese children aged 6-12 years, through comparison with the Social Responsiveness Scale (SRS) that has been widely used for ASD screening. We recruited the parents/caregivers of 1588 typically-developing children and 190 children with ASD aged 6-12 years to complete the MC-ASRS and SRS, and evaluated the validity of both scales in discriminating children with ASD from those developing typically. The results showed that MC-ASRS performed as well as SRS in sensitivity, specificity, and area-under-the-curve (both >0.95) in receiver operating characteristic analysis, with a fair false-negative rate. These results suggest that MC-ASRS is a promising tool for screening for children with ASD in the general Chinese population.
authors.affiliation: Department of Child Healthcare, Children's Hospital of Fudan University, Shanghai, 201102, China.
authors.forename: Bingrui
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Children's Hospital of Fudan University, Shanghai, 201102, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhou
authors.affiliation: School of Public Health, Harbin Medical University, Harbin, 150081, China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Wu
authors.affiliation: Child Development Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zou
authors.affiliation: Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
authors.forename: Xuerong
authors.initials: X
authors.lastname: Luo
authors.affiliation: Oregon Health and Science University, Portland, OR, 97239, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Fombonne
authors.affiliation: Department of Neurology, Children's Hospital of Fudan University, Shanghai, 201102, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Clinical Epidemiology, Children's Hospital of Fudan University, Shanghai, 201102, China. yanwl@fudan.edu.cn.
authors.forename: Weili
authors.initials: W
authors.lastname: Yan
authors.affiliation: Department of Child Healthcare, Children's Hospital of Fudan University, Shanghai, 201102, China. xuxiu1006@126.com.
authors.forename: Xiu
authors.initials: X
authors.lastname: Xu
mesh_terms: D000367:Age Factors; D000067877:Autism Spectrum Disorder / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D002648:Child; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods* / Q000592:standards; D010290:Parents / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012372:ROC Curve; D012189:Retrospective Studies; D012737:Sex Factors; D012920:Social Behavior Disorders / Q000175:diagnosis* / Q000209:etiology*
keywords: Autism spectrum disorder; Modified Chinese Autism Spectrum Rating Scale; ROC analysis; Screening accuracy; Social Responsiveness Scale