title: Association of migraine with asthma risk: A retrospective population-based cohort study.
abstract: BACKGROUND
  Both migraine and asthma are common health problems in the general population. However, the association between these two disorders is yet to be fully explored.
  
  
  OBJECTIVE
  We examined whether adult patients with migraine are at a higher risk of asthma development.
  
  
  METHODS
  We used data retrieved from the National Health Insurance Research Database in Taiwan to conduct this nationwide population-based cohort study. We identified 6647 patients aged 20-60 years who were newly diagnosed with migraine between 2000 and 2005 for the migraine group and identified 26 588 patients without migraine for the nonmigraine group. Both groups were followed up until the end of 2011 to examine the incidence of asthma. Cox proportional hazards regression analysis was used to measure the hazard ratio (HR) of asthma in the migraine group compared with the nonmigraine group.
  
  
  RESULTS
  The HR of asthma development was 1.37 (95% confidence interval = 1.21-1.56) for the migraine group compared with the nonmigraine group after adjustment for age, sex, occupational status, insurance premium, urbanization, comorbidities, and annual outpatient department visits. Further stratified analysis revealed that this risk was also significantly higher for both sexes and in the 40- to 60-year age group. The main limitation of this study was that some relevant data were unavailable, such as pain medication prescriptions and family history of migraine and asthma.
  
  
  CONCLUSIONS
  Adult patients with migraine are at a higher future risk of asthma development.
authors.affiliation: Department of Public Health, China Medical University, Taichung, Taiwan.|Department of Respiratory Therapy, Asia University Hospital, Asia University, Taichung, Taiwan.|Department of Respiratory Therapy, China Medical University, Taichung, Taiwan.
authors.forename: Yi-Hao
authors.identifier: http://orcid.org/0000-0001-9104-4487
authors.initials: YH
authors.lastname: Peng
authors.affiliation: Department of Neurology, China Medical University Hospital, China Medical University, Taichung, Taiwan.|Department of Neurology, China Medical University Beigang Hospital, Yunlin, Taiwan.
authors.forename: Kuan-Fei
authors.initials: KF
authors.lastname: Chen
authors.affiliation: College of Medicine, China Medical University, Taichung, Taiwan.|Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.
authors.forename: Wei-Chih
authors.initials: WC
authors.lastname: Liao
authors.affiliation: Department of Respiratory Therapy, China Medical University, Taichung, Taiwan.|Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.
authors.forename: Te-Chun
authors.initials: TC
authors.lastname: Hsia
authors.affiliation: College of Medicine, China Medical University, Taichung, Taiwan.|Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Hsuan-Ju
authors.initials: HJ
authors.lastname: Chen
authors.affiliation: Department of Public Health, China Medical University, Taichung, Taiwan.|Department of Respiratory Therapy, China Medical University Hospital, China Medical University, Taichung, Taiwan.
authors.forename: Ming-Chien
authors.initials: MC
authors.lastname: Yin
authors.affiliation: Department of Public Health, China Medical University, Taichung, Taiwan.
authors.forename: Wen-Chao
authors.initials: WC
authors.lastname: Ho
mesh_terms: D000328:Adult; D001249:Asthma / Q000453:epidemiology*; D015897:Comorbidity / Q000639:trends; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000453:epidemiology*; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
keywords: National Health Insurance Research Database; asthma; cohort study; comorbidity; epidemiology; migraine