title: Decreased HHV-6 IgG in Alzheimer's Disease.
abstract: Human herpesviruses have previously been implicated in the pathogenesis of Alzheimer's disease (AD) but whether they are causal, facilitating, or confounding factors is yet to be established. A total of 50 AD subjects and 52 non-demented (ND) controls were analyzed in a multiplex assay for IgG reactivity toward herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), and human herpesvirus 6 (HHV-6). The HHV-6 IgG reactivity was significantly lower in AD subjects compared to ND controls, whereas there were no differences in HSV, VZV, or CMV antibody levels between the groups. Analysis of peripheral blood mononuclear cells with a subtype-specific HHV-6 PCR revealed no signs of reactivation, as AD and ND subjects presented with comparable HHV-6 DNA levels in PBMCs, and all positive samples were of subtype B. Whether HHV-6 is a factor in AD remains to be elucidated in future studies.
authors.affiliation: Department of Medical Sciences, Uppsala University , Uppsala , Sweden.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Westman
authors.affiliation: Department of Medical Sciences, Uppsala University , Uppsala , Sweden.
authors.forename: Jonas
authors.initials: J
authors.lastname: Blomberg
authors.affiliation: Department of Laboratory Medicine, Karolinska Institutet , Stockholm , Sweden.
authors.forename: Zhibing
authors.initials: Z
authors.lastname: Yun
authors.affiliation: Department of Public Health and Caring Sciences, Uppsala University , Uppsala , Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Lannfelt
authors.affiliation: Department of Public Health and Caring Sciences, Uppsala University , Uppsala , Sweden.
authors.forename: Martin
authors.initials: M
authors.lastname: Ingelsson
authors.affiliation: Department of Medical Sciences, Uppsala University , Uppsala , Sweden.
authors.forename: Britt-Marie
authors.initials: BM
authors.lastname: Eriksson
keywords: Alzheimer’s disease; HHV-6; IgG; herpesvirus; immunoassay; multiplex