title: CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas.
abstract: The expression of CD40 ligand (CD40L) in mast cells was investigated in biopsies from lesional and non-lesional skin samples of patients with psoriasis, actinic keratosis (AK), basal cell carcinoma, and squamous cell carcinoma using a sequential double-staining technique. The percentage of CD40L+mast cells was higher in the lesional than in the non-lesional skin (p < .003). Interestingly, this percentage was lower in both carcinomas than in psoriasis and actinic keratosis (p < .025). Cells immunopositive for CD40 receptor were increased in all lesion types but especially so in carcinomas. The results suggest a dysregulated anti-tumoral immune response by mast cell CD40L in skin carcinomas.
authors.affiliation: a Department of Dermatology , Kuopio University Hospital and University of Eastern Finland , Kuopio , Finland.
authors.forename: Salla
authors.initials: S
authors.lastname: Haimakainen
authors.affiliation: a Department of Dermatology , Kuopio University Hospital and University of Eastern Finland , Kuopio , Finland.
authors.forename: Antti P
authors.initials: AP
authors.lastname: Kaukinen
authors.affiliation: a Department of Dermatology , Kuopio University Hospital and University of Eastern Finland , Kuopio , Finland.
authors.forename: Mireille-Maria
authors.initials: MM
authors.lastname: Suttle
authors.affiliation: b Department of Clinical Microbiology , Kuopio University Hospital and University of Eastern Finland , Kuopio , Finland.
authors.forename: Jukka
authors.initials: J
authors.lastname: Pelkonen
authors.affiliation: a Department of Dermatology , Kuopio University Hospital and University of Eastern Finland , Kuopio , Finland.
authors.forename: Ilkka T
authors.initials: IT
authors.lastname: Harvima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D023201:CD40 Ligand / Q000378:metabolism*; D002280:Basal Cell Carcinoma / Q000378:metabolism* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D055623:Keratosis, Actinic / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D008875:Middle Aged; D011565:Psoriasis / Q000378:metabolism* / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology; D053802:Tryptases / Q000378:metabolism
chemical_list: D023201:CD40 Ligand; D053802:Tryptases
keywords: Actinic keratosis; CD40 ligand; mast cell; psoriasis; skin carcinoma