title: [Multiple lncRNAs affect the incidence and  development of melanoma].
abstract: To find the relationship between long non-coding RNA (lncRNA) based on data mining methods.  Methods: We use a whole genome mRNA expression data set (GSE15605) from the gene expression ominibus database to find the lncRNAs which relate to melanoma.  Results: Four lncRNAs (LINC01213, PGM5-AS1, LINC01133 and LOC284578) were significantly associated with the incidence and development of melanoma. Meanwhile, LINC01213, LINC01133 and LOC284578 were correlated with BRAF mutation, and PGM5-AS1 was related to NRAS mutation. Data mining study found that the model based on the expression values of these 4 lncRNAs can easily preferable classify the study samples.  Conclusion: LncRNAs may play important roles in the incidence and development of melanoma.
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
authors.forename: Han
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Tan
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Xie
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
authors.forename: Zhaoqian
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Li
mesh_terms: D020558:GTP Phosphohydrolases / Q000235:genetics; D006801:Humans; D015994:Incidence; D008545:Melanoma / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics; D009154:Mutation / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D062085:RNA, Long Noncoding / Q000502:physiology*; D012333:RNA, Messenger
chemical_list: D008565:Membrane Proteins; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D020558:GTP Phosphohydrolases; C579846:NRAS protein, human