title: Tumour and placenta establishment: The importance of antigen processing and presentation.
abstract: Classical and non-classical MHC class I (MHC I) molecules displayed at the cell surface are essential for the induction of innate and adaptive immune responses. Classical MHC I present endogenously derived peptides to CD8+T cells for immunosurveillance of infected or malignant cells. By contrast, non-classical MHC I, in particular HLA-G, also display peptides, but primarily act as immunomodulatory ligands for the innate immune response and are an important component for extravillous trophoblast invasion to form the placenta in pregnancy. Endoplasmic Reticulum AminoPeptidase 1 (ERAP1), which trims peptides in the ER to generate ligands for MHC I loading, is a key regulator of the peptide repertoire and has a significant impact on the formation of stable MHC I at the cell surface. ERAP1 also plays a role in angiogenesis, cell cycle progression and migration, events that are shared between tumour cells and placenta formation. Here we discuss the similarities between tumour and extravillous trophoblast cells in their immune modulatory, invasion, migration and proliferation properties in the context of ERAP1 and its role in establishment of solid tumours and placenta formation.
authors.affiliation: Cancer Sciences Unit, Somers Cancer Research Building, Mailpoint 824, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Reeves
authors.affiliation: Cancer Sciences Unit, Somers Cancer Research Building, Mailpoint 824, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK. Electronic address: eddjames@soton.ac.uk.
authors.forename: Edward
authors.initials: E
authors.lastname: James
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D005260:Female; D005805:Genes, MHC Class I / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism; D010920:Placenta / Q000276:immunology* / Q000378:metabolism; D010929:Placentation / Q000276:immunology*; D011247:Pregnancy
keywords: Antigen processing and presentation; Cervical carcinoma; MHC; Placental implantation