title: Aspergchromones A and B, two new polyketides from the marine sponge-associated fungus Aspergillus sp. SCSIO XWS03F03.
abstract: Two new polyketides, aspergchromones A (1) and B (2), together with five known compounds, secalonic acid D (3), noreugenin (4), (3S)-5-hydroxymellein (5), (4S)-6-hydroxyisosclerone (6), and (-)-regiolone (7), were isolated from the ethyl acetate extract of marine sponge-derived fungus Aspergillus sp. SCSIO XWS03F03. Their structures were elucidated by means of spectroscopic techniques (1D and 2D NMR, MS, UV, and IR). The absolute configurations of the new compounds were established by ECD calculations. Compound 3 showed moderate antimicrobial activity.
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: b Key Laboratory of Tropical Marine Bio-resources and Ecology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , China.
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Lin
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , China.
authors.forename: Zhi-Ran
authors.initials: ZR
authors.lastname: Ju
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , China.
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Liao
authors.affiliation: c College of Pharmacy , Jinan University , Guangzhou 510632 , China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.affiliation: b Key Laboratory of Tropical Marine Bio-resources and Ecology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , China.
authors.forename: Bing-Xin
authors.initials: BX
authors.lastname: Zhao
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , China.
authors.forename: Shi-Hai
authors.initials: SH
authors.lastname: Xu
mesh_terms: D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera / Q000382:microbiology*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D061065:Polyketides; D044004:Xanthones; C000621769:aspergchromone A; C000621770:aspergchromone B; C009218:secalonic acid
keywords: Aspergillus sp. SCSIO XWS03F03; antimicrobial; polyketides