title: Effect of animal products and extracts on wound healing promotion in topical applications: a review.
abstract: Wound healing is a natural process of body reaction to repair itself after injury. Nonetheless, many internal and external factors such as aging, comorbidity, stress, smoking, alcohol drinking, infections, malnutrition, or wound environment significantly affect the quality and speed of wound healing. The unsuitable conditions may delay wound healing process and cause chronic wound or scar formation. Therefore, many researches have attempted to search for agents that can accelerate wound healing with safety and biocompatibility to human body. Widely studied wound healing agents are those derived from either natural sources including plants and animals or chemical synthesis. The natural products seem to be safer and more biocompatible to human tissue. This review paper demonstrated various kinds of the animal-derived products including chitosan, collagen, honey, anabolic steroids, silk sericin, peptides, and proteoglycan in term of mechanisms of action, advantages, and disadvantages when applied as wound healing accelerator. The benefits of these animal-derived products are wound healing promotion, anti-inflammatory, antimicrobial activity, moisturizing effect, biocompatibility, and safety. However, the drawbacks such as allergy, low stability, batch-to-batch variability, and high extraction and purification costs could not be avoided in some products.
authors.affiliation: a Bioactive Resources for Innovative Clinical Applications Research Unit, Chulalongkorn University , Bangkok , Thailand.|b Faculty of Pharmaceutical Sciences, Department of Pharmacy Practice , Chulalongkorn University , Bangkok , Thailand.
authors.forename: Supamas
authors.initials: S
authors.lastname: Napavichayanun
authors.affiliation: a Bioactive Resources for Innovative Clinical Applications Research Unit, Chulalongkorn University , Bangkok , Thailand.|b Faculty of Pharmaceutical Sciences, Department of Pharmacy Practice , Chulalongkorn University , Bangkok , Thailand.
authors.forename: Pornanong
authors.initials: P
authors.lastname: Aramwit
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000494:pharmacology; D001688:Biological Products / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D001688:Biological Products
keywords: Wound healing; anabolic steroids; chitosan; collagen; honey; hyaluronic acid; keratin; peptides; proteoglycan; silk sericin