title: Beneficial effects of lipidic extracts of saladette tomato pomace and Serenoa repens on prostate and bladder health in obese male Wistar rats.
abstract: BACKGROUND
  Obesity is associated with increased risk of a number of serious medical conditions, including urological disorders. This study investigated the effect of lipidic extracts of saladette tomato pomace (STP) and Serenoa repens (SR) on the prostate and bladder in a rat obese model induced by high-carbohydrate diet.
  
  
  RESULTS
  High-sucrose-fed rats showed higher prostate weight as well as increased contractility and stromal and epithelial hyperplasia in the prostate. Treatment with STP and SR improved contractility and diminished hyperplasia and hypertrophy in the prostate. Obese animals also showed impaired bladder contractility, but neither extract reversed this deterioration. In the histological study, a disarray in the process of smooth muscle cell proliferation with non-parallel fibers was observed; interestingly, treatment with STP and SR led to improvement in this derangement.
  
  
  CONCLUSIONS
  These findings indicated impaired contractility and hyperplasia in the prostate and bladder of obese rats induced by high sucrose. STP and SR could enhance prostate function by reducing contractility and hyperplasia and improve smooth muscle fiber structure and decrease cell proliferation in the bladder, suggesting their possible health-beneficial effects on lower urinary tract symptoms. © 2017 Society of Chemical Industry.
authors.affiliation: Pharmacobiology Department, Cinvestav-IPN, México City, Mexico.
authors.forename: Josué V
authors.initials: JV
authors.lastname: Espinosa-Juárez
authors.affiliation: Pharmacobiology Department, Cinvestav-IPN, México City, Mexico.
authors.forename: Juventino Iii
authors.initials: JI
authors.lastname: Colado-Velázquez
authors.affiliation: Pharmacobiology Department, Cinvestav-IPN, México City, Mexico.
authors.forename: Patrick
authors.initials: P
authors.lastname: Mailloux-Salinas
authors.affiliation: Pharmacobiology Department, Cinvestav-IPN, México City, Mexico.
authors.forename: Jml
authors.initials: J
authors.lastname: Medina-Contreras
authors.affiliation: Pharmacobiology Department, Cinvestav-IPN, México City, Mexico.
authors.forename: P Valentín
authors.initials: PV
authors.lastname: Correa-López
authors.affiliation: Pharmacobiology Department, Cinvestav-IPN, México City, Mexico.
authors.forename: Norma L
authors.initials: NL
authors.lastname: Gómez-Viquez
authors.affiliation: Pharmacobiology Department, Cinvestav-IPN, México City, Mexico.
authors.forename: Fabián
authors.initials: F
authors.lastname: Meza-Cuenca
authors.affiliation: Department of Pharmacology and Toxicology, Hospital Infantil de México Federico Gómez, México City, Mexico.
authors.forename: Fengyang
authors.initials: F
authors.lastname: Huang
authors.affiliation: Pharmacobiology Department, Cinvestav-IPN, México City, Mexico.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Bravo
mesh_terms: D000818:Animals; D006801:Humans; D018551:Solanum lycopersicum / Q000737:chemistry*; D008297:Male; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage*; D011467:Prostate / Q000187:drug effects* / Q000503:physiopathology; D011469:Prostatic Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D028024:Serenoa / Q000737:chemistry*; D001743:Urinary Bladder / Q000187:drug effects* / Q000503:physiopathology; D001745:Urinary Bladder Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology
chemical_list: D010936:Plant Extracts
keywords: Serenoa repens; bladder; lycopene; obesity; prostate; rats