title: Effects of lactulose and silymarin on liver enzymes in cirrhotic rats.
abstract: Silymarin, a mixture of antihepatotoxic flavonolignans used in the treatment of liver diseases, and lactulose, a nonabsorbable synthetic disaccharide, were investigated to analyze their probable synergic and healing effects in a hepatic cirrhotic rat model. Liver damage was induced by the administration and subsequent withdrawal of thioacetamide. The significant decrease in liver enzymes and malondialdehyde levels confirmed the curative effects of silymarin and lactulose. In the silymarin + lactulose group, liver enzyme and malondialdehyde levels were significantly reduced compared with those in the thioacetamide group. All treatments led to liver regeneration and triggered enhanced regeneration. Silymarin and lactulose alone or in combination have potent curative effects and reduce thioacetamide-induced liver damage.
authors.affiliation: a Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Shahid Mostafa Ahmadi Roshan Boulevard, Hamedan, Iran.
authors.forename: Mozhgan
authors.initials: M
authors.lastname: Ghobadi Pour
authors.affiliation: a Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Shahid Mostafa Ahmadi Roshan Boulevard, Hamedan, Iran.
authors.forename: Naser
authors.initials: N
authors.lastname: Mirazi
authors.affiliation: b Department of Physiology, Faculty of Medicine, Isfahan University of Medical Sciences, Hezar-Jerib Avenue, Isfahan, Iran.
authors.forename: Hojjatollah
authors.initials: H
authors.lastname: Alaei
authors.affiliation: c Department of Pharmacognosy, Faculty of Pharmacy, Hamadan University of Medical Sciences, Shahid Fahmideh Boulevard, Hamadan, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Moradkhani
authors.affiliation: b Department of Physiology, Faculty of Medicine, Isfahan University of Medical Sciences, Hezar-Jerib Avenue, Isfahan, Iran.
authors.forename: Ziba
authors.initials: Z
authors.lastname: Rajaei
authors.affiliation: d Department of Pathology, Hamadan University of Medical Sciences, Shahid Fahmideh Boulevard, Hamadan, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Monsef Esfahani
mesh_terms: D000818:Animals; D004347:Drug Interactions; D007792:Lactulose / Q000494:pharmacology* / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology* / Q000378:metabolism; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000494:pharmacology* / Q000627:therapeutic use; D013853:Thioacetamide / Q000494:pharmacology
chemical_list: D012838:Silymarin; D013853:Thioacetamide; D007792:Lactulose
keywords: cirrhose hépatique; liver cirrhosis; rat; silymarin; silymarine; thioacetamide; thioacétamide