title: Synthesis, characterization and biological evaluation of ruthenium flavanol complexes against breast cancer.
abstract: Four Ru(II) DMSO complexes (M1R-M4R) having substituted flavones viz. 3-Hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one (HL1), 3-Hydroxy-2-(4-nitrophenyl)-4H-chromen-4-one (HL2), 3-Hydroxy-2-(4-dimethylaminophenyl)-4H-chromen-4-one (HL3) and 3-Hydroxy-2-(4-chlorophenyl)-4H-chromen-4-one (HL4) were synthesized and characterized by elemental analysis, IR, UV-Vis,1H NMR spectroscopies and ESI-MS. The molecular structures of the complexes were investigated by integrated spectroscopic and computational techniques (DFT). Both ligands as well as their complexes were screened for anticancer activities against breast cancer cell lines MCF-7. Cytotoxicity was assayed by MTT [3-(4, 5-dimethyl thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. All ligands and their complexes exhibited significant cytotoxic potential of 5-40μM concentration at incubation period of 24h. The cell cytotoxicity increased significantly in a concentration-dependent manner. In this series of compounds, HL2 (IC5017.2μM) and its complex M2R (IC5016μM) induced the highest cytotoxicity.
authors.affiliation: Department of Chemistry, University of Lucknow, Lucknow 226 007, India. Electronic address: singhaks3@rediffmail.com.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Singh
authors.affiliation: Department of Chemistry, University of Lucknow, Lucknow 226 007, India.
authors.forename: Gunjan
authors.initials: G
authors.lastname: Saxena
authors.affiliation: Department of Zoology, University of Lucknow, Lucknow 226 007, India.
authors.lastname: Sahabjada
authors.affiliation: Department of Zoology, University of Lucknow, Lucknow 226 007, India.
authors.forename: M
authors.initials: M
authors.lastname: Arshad
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms / Q000378:metabolism*; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D047309:Flavones / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D061986:MCF-7 Cells; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017975:Ruthenium Compounds / Q000737:chemistry / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: D000970:Antineoplastic Agents; D047309:Flavones; D009942:Organometallic Compounds; D017975:Ruthenium Compounds
keywords: Cytotoxicity; DFT; DMSO; Flavones; Ru(II)