title: Effect of Enhancers onin vitroandin vivoSkin Permeation and Deposition of S-Methyl-L-Methionine.
abstract: S-methyl-L-methionine (SMM), also known as vitamin U, is commercially available as skin care cosmetic products for its wound healing and photoprotective effects. However, the low skin permeation expected of SMM due to its hydrophilic nature with a log P value of -3.3, has not been thoroughly addressed. The purpose of this study thus was to evaluate the effect of skin permeation enhancers on the skin permeation/deposition of SMM. Among the enhancers tested for thein vitroskin permeation and deposition of SMM, oleic acid showed the most significant enhancing effect. Moreover, the combination of oleic acid and ethanol further enhancedin vitropermeation and deposition of SMM through hairless mouse skin. Furthermore, the combination of oleic acid and ethanol significantly increased thein vivodeposition of SMM in the epidermis/dermis for 12 hr, which was high enough to exert a therapeutic effect. Therefore, based on thein vitroandin vivostudies, the combination of oleic acid and ethanol was shown to be effective in improving the topical skin delivery of SMM, which may be applied in the cosmetic production process for SMM.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
authors.forename: Ki Taek
authors.initials: KT
authors.lastname: Kim
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
authors.forename: Ji Su
authors.initials: JS
authors.lastname: Kim
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
authors.forename: Min-Hwan
authors.initials: MH
authors.lastname: Kim
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
authors.forename: Ju-Hwan
authors.initials: JH
authors.lastname: Park
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
authors.forename: WooIn
authors.initials: W
authors.lastname: Lee
authors.affiliation: CUSKIN Cosmeceutical and Biotechnology, Seoul 06530, Republic of Korea.
authors.forename: Kyung Kuk
authors.initials: KK
authors.lastname: Min
authors.affiliation: CUSKIN Cosmeceutical and Biotechnology, Seoul 06530, Republic of Korea.
authors.forename: Min Gyu
authors.initials: MG
authors.lastname: Song
authors.affiliation: CUSKIN Cosmeceutical and Biotechnology, Seoul 06530, Republic of Korea.
authors.forename: Choon-Young
authors.initials: CY
authors.lastname: Choi
authors.affiliation: Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea.
authors.forename: Won-Serk
authors.initials: WS
authors.lastname: Kim
authors.affiliation: Department of Food and Nutrition, Jangan University, Hwaseong 18331, Republic of Korea.
authors.forename: Hee Kyung
authors.initials: HK
authors.lastname: Oh
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
authors.forename: Dae-Duk
authors.initials: DD
authors.lastname: Kim
keywords: Deposition; Enhancers; S-methyl-L-methionine; Skin permeation; Vitamin U