title: Relation between Hypofractionated Radiotherapy, Toxicity and Outcome in Early Breast Cancer.
abstract: To compare adjuvant conventional radiotherapy (C-RT) to hypofractionated schedule (HF-RT) in early breast cancer. Between May 2012 and September 2015, 120 patients were included in the analysis. All patients underwent conservative surgery and adjuvant RT. RT was delivered in C-RT (50 Gy; 2 Gy/fr) or HF-RT (42.5 Gy; 2.66 Gy/fr), followed by a tumor bed boost (10 Gy; 2 Gy/fr). RT-induced toxicity was recorded and compared between groups. Toxicity results were graded according to the Common Terminology Criteria for Adverse Events guidelines. A multivariate analysis was performed of the factors associated with acute toxicity onset. Mild acute skin toxicity was observed in 71.7% of patients. No grade 4 toxicity was observed. From the multivariate analysis, Breast volume and RT fractionation significantly affected acute radiation-related toxicity. No increase in late toxic effects has been reported between C-RT and HF-RT schedules. Overall, the 2-year disease free survival was 94.4%. HF-RT represents a valid adjuvant treatment option in early breast cancer patients, without negative impact on acute and late radiation sequelae, as well as tumor control.
authors.affiliation: Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: De Felice
authors.affiliation: Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Ranalli
authors.affiliation: Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Musio
authors.affiliation: Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Lisi
authors.affiliation: Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Rea
authors.affiliation: Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Caiazzo
authors.affiliation: Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.|Spencer-Lorillard Foundation, Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Tombolini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D000069473:Radiation Dose Hypofractionation; D011832:Radiation Injuries; D018714:Radiotherapy, Adjuvant; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: breast cancer; conventional treatment; cosmetic results; hypofractionated scheme; whole breast irradiation