title: [Clinical comparative analysis of comprehensive laparoscopic and laparotomic staging of early-stage epithelial ovarian cancer].
abstract: Objective:To investigate the value of laparoscopy in comprehensive early ovarian cancer staging by comparing the feasibility and safety of laparoscopy and laparotomy in surgical staging of early-stage epithelial ovarian cancer (EOC).Methods:A total of 102 patients with EOC who underwent comprehensive laparoscopic (LPS group,n=71) or laparotomic (LPT group,n=31) staging at Southwest Hospital from November 2007 to November 2014 were retrospectively analyzed. The perioperative parameters, postoperative complication rate and the long-term curative effect were compared between the two groups.Results:(1) LPS group had less intra-operative blood loss [(288±239) vs (631±463) ml], lower rate of blood transfusion (14% vs 58%) , larger number of pelvic dissected lymph nodes (18.1±5.6 vs 15.5±4.6), lower vasual analogue scalescore (VAS) pain score (2.1±1.6 vs 3.0±1.1), shorter gastrointestinal recovery time [(2.6±0.8) vs (3.5±0.9) days] and shorter hospital stay [(9.9±2.9) vs (11.3±5.0) days] when compared with LPT group (allP<0.01). No significant difference were found in operation time, number of para-aortic lymph nodes, rate of postoperative upstaging and adjuvant chemotherapy between the two groups (allP>0.05). (2) No significant difference was found in postoperative rate of complications [11%(8/71) vs 19% (6/31), χ(2)=1.192,P=0.275]. (3) No significant difference was found in recurrence rate [17%(11/66) vs 14%(4/29), χ(2)=0.125,P=0.724] and 5-year overall survival (86.7% vs 86.8%,P=0.874) .Conclusion:Compared with LPT group, there are no significance differences in recurrence rate and mortality between two groups, laparoscopic staging, which could be recommended as a choice of surgical treatment of early ovarian cancer, shows more favorable operative outcomes including minimally invasive, less intra-operative blood loss, less postoperative pain and quicker recovery.
authors.affiliation: Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: W
authors.initials: W
authors.lastname: Xiong
authors.forename: L L
authors.initials: LL
authors.lastname: Cao
authors.forename: L P
authors.initials: LP
authors.lastname: Jiang
authors.forename: H
authors.initials: H
authors.lastname: Xia
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Liang
mesh_terms: D016063:Blood Loss, Surgical; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D002681:China / Q000453:epidemiology; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000706:statistics & numerical data*; D007813:Laparotomy / Q000706:statistics & numerical data*; D007902:Length of Stay; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008875:Middle Aged; D009367:Neoplasm Staging; D061646:Operative Time; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D011184:Postoperative Period; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Comparative study; Laparoscopy; Laparotomy; Neoplasm staging; Ovarian neoplasms