title: [Clinical analysis of 82 cases of generalized pustular psoriasis].
abstract: To analyze clinical features, laboratory tests, treatment and prognosis for patients with generalized pustular psoriasis (GPP).  Methods: Clinical data of 82 patients with GPP (16 cases of children, 66 cases of adults) from the Department of Dermatology, Second Xiangya Hospital, Central South University were retrospectively analyzed.  Results: Among the GPP patients, the male to female ratio was 1:1.1. Average age of onset in patients without history of psoriasis vulgaris (GPPPSO-) was earlier than that of patients with history of psoriasis vulgaris (GPPPSO+)[(25.5±21.2) years vs (32.7±18.0) years]. The average day of hospitalization in GPPPSO- group was longer than that in GPPPSO+ group [(12.1±6.7) days vs (11.6±10.2) days]. The transformation time from psoriasis vulgaris to GPP was (77.8±71.9) months. Infection (33.3%) and drugs (33.3%) were the main etiological factors in children with GPP. In adults with GPP, 75.0% of GPPPSO+ patients were caused by infection, but 41.7% of GPPPSO- patients were caused by drugs. Acitretin had favorable effect in the treatment of GPP.  Conclusion: The clinical features of GPP in children and adults are different. Acitretin could be considered as a ﬁrst-line therapy for GPP in children and adults, but corticosteroid should be used cautiously.
authors.affiliation: Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Li
mesh_terms: D017255:Acitretin / Q000627:therapeutic use; D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D017668:Age of Onset; D002648:Child; D018450:Disease Progression; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D011379:Prognosis; D011565:Psoriasis / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones; D017255:Acitretin