title: [Comparison of vaginal use of micronized progesterone for the luteal support. Randomized study comparison of Utrogestan and Crinone 8].
abstract: OBJECTIVE
  The study was focused on comparison of efficiency, safety and tolerance of vaginal use of micronized progesterone in preparations Utrogestan and Crinone 8%.
  
  
  METHODS
  Prospective randomized study.
  
  
  METHODS
  Department of Gynecology and Obstetric, University Hospital, Olomouc, Faculty of Medicine and Dentistry, Palacky University, Olomouc.
  
  
  METHODS
  Into a prospective randomized study was, after calculation of 80% of the power of the study, α = 0,05, included 111 women in age between 18-40 with a basal value FSH < 10 IU/l and a normal finding in uteral cavity. After evaluation of efficiency of both preparations there was selected a fertilization rate, an implantation rate, a pregnancy rate and a take-home baby rate. Comparison of tolerance was made from evaluation of 21 parameters which were obtained through a questionnaire.
  
  
  RESULTS
  There were not been proven any significant differences in efficiency between both preparations. Crinone 8% was in patients better tolerated.
  
  
  CONCLUSIONS
  Luteal support within the IVF/ICSI-ET remains an integral part of the treatment. According to the outcomes of the study it seems to be more suitable to use a vaginal gel for the luteal support with micronized progesterone.
authors.forename: L
authors.initials: L
authors.lastname: Michnová
authors.forename: J
authors.initials: J
authors.lastname: Dostál
authors.forename: K
authors.initials: K
authors.lastname: Langová
authors.forename: T
authors.initials: T
authors.lastname: Rumpíková
authors.forename: M
authors.initials: M
authors.lastname: Kudela
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008183:Luteal Phase; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D011372:Progestins / Q000627:therapeutic use*; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic
chemical_list: C400424:Crinone; D011372:Progestins; D011374:Progesterone
keywords: luteal phase support IVF/ET.