title: Feasibility of collecting tumor samples of breast cancer patients diagnosed up to 50 years ago in the Child Health and Development Studies.
abstract: Environmental exposures during pregnancy may increase breast cancer risk for mothers and female offspring. Tumor tissue assays may provide insight regarding the mechanisms. This study assessed the feasibility of obtaining tumor samples and pathology reports from mothers (F0) who were enrolled in the Child Health and Development Studies during pregnancy from 1959 to 1967 and their daughters (F1) who developed breast cancer over more than 50 years of follow-up. Breast cancer cases were identified through linkage to the California Cancer Registry and self-report. Written consent was obtained from 116 F0 and 95 F1 breast cancer survivors to access their pathology reports and tumor blocks. Of those contacted, 62% consented, 13% refused and 24% did not respond. We obtained tissue samples for 57% and pathology reports for 75%, and if diagnosis was made ⩽10 years we obtained tissue samples and pathology reports for 91% and 79%, respectively. Obtaining pathology reports and tumor tissues of two generations is feasible and will support investigation of the relationship between early-life exposures and molecular tumor markers. However, we found that more recent diagnosis increased the accessibility of tumor tissue. We recommend that cohorts request consent for obtaining future tumor tissues at study enrollment and implement real-time tissue collection to enhance success of collecting tumor samples and data.
authors.affiliation: 1Child Health and Development Studies,Public Health Institute,Oakland,CA,USA.
authors.forename: N Y
authors.initials: NY
authors.lastname: Krigbaum
authors.affiliation: 1Child Health and Development Studies,Public Health Institute,Oakland,CA,USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Rubin
authors.affiliation: 1Child Health and Development Studies,Public Health Institute,Oakland,CA,USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Cirillo
authors.affiliation: 2Columbia University,Mailman School of Public Health,New York,NY,USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Terry
authors.affiliation: 3Division of Research,Kaiser Permanente Northern California,Oakland,CA,USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Habel
authors.affiliation: 4California Cancer Reporting and Epidemiologic Surveillance Program,Institute for Population Health Improvement,UCD Health System,Sacramento,CA,USA.
authors.forename: C
authors.initials: C
authors.lastname: Morris
authors.affiliation: 1Child Health and Development Studies,Public Health Institute,Oakland,CA,USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Cohn
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D002648:Child; D002657:Child Development / Q000502:physiology; D000067576:Child Health / Q000592:standards / Q000639:trends*; D015331:Cohort Studies; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D012042:Registries / Q000592:standards; D013048:Specimen Handling / Q000379:methods / Q000592:standards / Q000639:trends*; D013997:Time Factors
keywords: Child Health and Development Studies; PEDIGREE study; breast cancer prevention; pathology reports; tumor sample collection