title: MRI ventilation abnormalities predict quality-of-life and lung function changes in mild-to-moderate COPD: longitudinal TINCan study.
abstract: : COPD biomarkers are urgently required for clinical trials of new therapies. We evaluated the longitudinal change and relationship of MRI and CT biomarkers of COPD with St. George's Respiratory Questionnaire (SGRO) and FEV1worsening over 30 months. Among imaging biomarkers, only the longitudinal change in MRI ventilation defect percent (VDP) was greater in ever-smoker (n=34/p<0.05) and COPD (n=48/p<0.0001) subgroups compared with never-smokers (n=42). Only the longitudinal change in VDP was correlated with change in SGRQ (r=0.26/p=0.03), and only baseline VDP predicted longitudinal change in SGRQ>minimum clinically important difference (p=0.047) in mild-to-moderate COPD. These data strongly support the use of MRI intermediate endpoints in COPD studies.
  
  
  BACKGROUND
  NCT02723474; Status: Recruiting.
authors.affiliation: Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.
authors.forename: Miranda
authors.initials: M
authors.lastname: Kirby
authors.affiliation: Robarts Research Institute, The University of Western Ontario, London, Canada.|Department of Medical Biophysics, The University of Western Ontario, London, Canada.
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Eddy
authors.affiliation: Robarts Research Institute, The University of Western Ontario, London, Canada.|Department of Medical Biophysics, The University of Western Ontario, London, Canada.
authors.forename: Damien
authors.initials: D
authors.lastname: Pike
authors.affiliation: Robarts Research Institute, The University of Western Ontario, London, Canada.|Department of Medical Biophysics, The University of Western Ontario, London, Canada.
authors.forename: Sarah
authors.initials: S
authors.lastname: Svenningsen
authors.affiliation: Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.
authors.forename: Harvey O
authors.identifier: http://orcid.org/0000-0001-5750-9711
authors.initials: HO
authors.lastname: Coxson
authors.affiliation: Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.
authors.forename: Don D
authors.initials: DD
authors.lastname: Sin
authors.affiliation: Division of Respirology, Department of Medicine, The University of Western Ontario, London, Canada.
authors.forename: David G
authors.initials: DG
authors.lastname: McCormack
authors.affiliation: Robarts Research Institute, The University of Western Ontario, London, Canada.|Department of Medical Biophysics, The University of Western Ontario, London, Canada.
authors.forename: Grace
authors.initials: G
authors.lastname: Parraga
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011788:Quality of Life; D012107:Research Design; D012129:Respiratory Function Tests; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers
keywords: Emphysema; Imaging/CT MRI etc; Respiratory Measurement