title: Clinical Utility of Using Lumbar Spine Trabecular Bone Score to Adjust Fracture Probability: The Manitoba BMD Cohort.
abstract: Decreased lumbar spine trabecular bone score (TBS), a dual-energy X-ray absorptiometry (DXA)-derived image texture measurement, is a risk factor for major osteoporotic fracture (MOF) and hip fracture (HF) independent of 10-year fracture probability estimated using FRAX. We determined how often applying the TBS adjustment to fracture probability altered treatment qualification. Using a population-based registry containing all clinical DXA results for Manitoba, Canada, we identified 34,316 women with baseline spine and hip DXA, FRAX-based fracture probability measurements (computed with femoral neck bone mineral density), lumbar spine TBS, and minimum 5 years of observation (mean 8.7 years). Population-based health services data were used to identify incident non-traumatic MOF and HF in 3503 and 945 women, respectively. Baseline MOF and HF probabilities were estimated using FRAX before and after applying the TBS adjustment. Risk recategorization was assessed using net reclassification improvement (NRI) for individual FRAX-based intervention criteria and three national clinical practice guidelines (CPGs) (US National Osteoporosis Foundation, Osteoporosis Canada, and UK National Osteoporosis Guideline Group). Overall, proportions of women reclassified with the TBS adjustment to FRAX were small (less than 5%) with more than 90% of the reclassification occurring close to the intervention threshold. For women close to an intervention cut-off reclassification, rates ranged from 9.0% to 17.9% and were <1% otherwise. There was a small but significant improvement in overall NRI for all individual FRAX-based intervention criteria (range 0.007 to 0.018) and all three national CPGs (range 0.008 to 0.011). NRI was larger in women below age 65 years (up to 0.056 for hip fracture). In summary, a small but significant improvement in MOF and HF risk assessment was found by using lumbar spine TBS to adjust FRAX probability. An improvement in risk reclassification was observed for CPGs from three different countries, with almost all of the benefit found in individuals close to an intervention threshold. © 2017 American Society for Bone and Mineral Research. © 2017 American Society for Bone and Mineral Research.
authors.affiliation: Department of Radiology, University of Ottawa, Ottawa, Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Martineau
authors.affiliation: Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
authors.forename: William D
authors.identifier: http://orcid.org/0000-0002-1056-1691
authors.initials: WD
authors.lastname: Leslie
authors.affiliation: Center for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK.|Institute for Health and Aging, Catholic University of Australia, Melbourne, Australia.
authors.forename: Helena
authors.initials: H
authors.lastname: Johansson
authors.affiliation: Center for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK.
authors.forename: Anders
authors.initials: A
authors.lastname: Oden
authors.affiliation: Center for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK.
authors.forename: Eugene V
authors.identifier: http://orcid.org/0000-0003-0177-8140
authors.initials: EV
authors.lastname: McCloskey
authors.affiliation: Bone and Joint Department, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Didier
authors.initials: D
authors.lastname: Hans
authors.affiliation: Center for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK.|Institute for Health and Aging, Catholic University of Australia, Melbourne, Australia.
authors.forename: John A
authors.initials: JA
authors.lastname: Kanis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D000071556:Cancellous Bone / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005265:Femoral Neck Fractures / Q000453:epidemiology* / Q000378:metabolism* / Q000473:pathology; D005272:Femur Neck / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000378:metabolism* / Q000473:pathology; D008350:Manitoba / Q000453:epidemiology; D008875:Middle Aged; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors