title: Oxycodone extended release capsules for the treatment of chronic pain.
abstract: As a consequence of greater prescription opioid utilization, there has been the parallel increase in misuse, abuse, and overdose, which are serious risks. Associated new formulations may be safer. Areas covered: The introduction of abuse-deterrent opioid formulations and continuous programs to improve opioid prescribing practices may limit the opioid abuse and its consequences. Oxycodone extended release capsules are an extended-release (ER), microsphere-in-capsule abuse-deterrent-formulation designed to retain its extended-release properties following tampering or misuse (e.g., chewing, crushing). Studies have reported that this preparation is efficacious in patients with low back pain, less attractive for illicit use, and an option for patients who have difficulty swallowing and erroneously crush their medication. Expert commentary: Preliminary data regarding oxycodone extended release capsules are encouraging. However, more data in different populations are necessary to confirm initial observations, and comparison should be performed with active substances.
authors.affiliation: a Palliative care program SAMO and University of Palermo , Palermo , Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Mercadante
mesh_terms: D000701:Analgesics, Opioid / Q000737:chemistry / Q000627:therapeutic use*; D002214:Capsules; D002648:Child; D059350:Chronic Pain / Q000188:drug therapy*; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D006801:Humans; D010098:Oxycodone / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000701:Analgesics, Opioid; D002214:Capsules; D003692:Delayed-Action Preparations; D010098:Oxycodone
keywords: Chronic pain; abuse-deterrent preparation; illicit use; opioids; oxycodone