title: Cholesterol Levels in Patients with Chronic Lymphocytic Leukemia.
abstract: Low cholesterol levels may be accompanied by solid tumors or hematological malignancies such as multiple myeloma. Decreased cholesterol levels have been reported in some experimental studies about chronic lymphocytic leukemia (CLL). It may be associated with tumoral cell metabolism. Herein, we examine blood lipid profiles of patients with newly diagnosed CLL (284 male, 276 female, mean age 64 ± 11 years) as defined by National Cancer Institute criteria. The control group consisted of 71 healthy subjects with mean age 55 ± 9 years (28 male, 43 females). 60% of patients with Binet A, while 25% were Binet C. Decreased levels of total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) were observed in patients with CLL than control group (p < 0,001). There was no statistical significance between CLL and control group for triglycerides (TG) and very low density lipoprotein (VLDL), also between HDL-C, VLDL, TG and grades. Cholesterol may metabolized by abnormal lymphocytes in CLL patients.
authors.affiliation: Adnan Menderes University, Faculty of Medicine, Department of Internal Medicine, Aydin, Turkey.
authors.forename: Irfan
authors.initials: I
authors.lastname: Yavasoglu
authors.affiliation: Adnan Menderes University, Faculty of Medicine, Department of Internal Medicine, Aydin, Turkey. Electronic address: gokhan_sargin@hotmail.com.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Sargin
authors.affiliation: Ege University, Faculty of Medicine, Division of Hematology, Izmir, Turkey.
authors.forename: Fergun
authors.initials: F
authors.lastname: Yilmaz
authors.affiliation: Gazi University, Faculty of Medicine, Division of Hematology, Ankara, Turkey.
authors.forename: Sermin
authors.initials: S
authors.lastname: Altındag
authors.affiliation: Bozyaka Training and Research Hospital, Izmir, Turkey.
authors.forename: Gulsum
authors.initials: G
authors.lastname: Akgun
authors.affiliation: Mersin University, Faculty of Medicine, Division of Hematology, Mersin, Turkey.
authors.forename: Anil
authors.initials: A
authors.lastname: Tombak
authors.affiliation: Bülent Ecevit University, Faculty of Medicine, Division of Hematology, Zonguldak, Turkey.
authors.forename: Bila
authors.initials: B
authors.lastname: Toka
authors.affiliation: Dicle University, Faculty of Medicine, Division of Hematology, Diyarbakir, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Dal
authors.affiliation: Karadeniz University, Faculty of Medicine, Division of Hematology, Trabzon, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Ozbas
authors.affiliation: Bezmialem University, Faculty of Medicine, Division of Hematology, Istanbul, Turkey.
authors.forename: Guven
authors.initials: G
authors.lastname: Cetin
authors.affiliation: Ege University, Faculty of Medicine, Division of Hematology, Izmir, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Donmez
authors.affiliation: Gazi University, Faculty of Medicine, Division of Hematology, Ankara, Turkey.
authors.forename: Zeynep Arzu
authors.initials: ZA
authors.lastname: Yegin
authors.affiliation: Bozyaka Training and Research Hospital, Izmir, Turkey.
authors.forename: Oktay
authors.initials: O
authors.lastname: Bilgir
authors.affiliation: Mersin University, Faculty of Medicine, Division of Hematology, Mersin, Turkey.
authors.forename: Naci
authors.initials: N
authors.lastname: Tiftik
authors.affiliation: Bülent Ecevit University, Faculty of Medicine, Division of Hematology, Zonguldak, Turkey.
authors.forename: Sehmus
authors.initials: S
authors.lastname: Ertop
authors.affiliation: Dicle University, Faculty of Medicine, Division of Hematology, Diyarbakir, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Ayyildiz
authors.affiliation: Karadeniz University, Faculty of Medicine, Division of Hematology, Trabzon, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sonmez
authors.affiliation: Adnan Menderes University, Faculty of Medicine, Department of Internal Medicine, Aydin, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Pektas
authors.affiliation: Adnan Menderes University, Faculty of Medicine, Department of Internal Medicine, Aydin, Turkey.
authors.forename: Gurhan
authors.initials: G
authors.lastname: Kadıkoylu
authors.affiliation: Ege University, Faculty of Medicine, Division of Hematology, Izmir, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Tombuloglu
authors.affiliation: Adnan Menderes University, Faculty of Medicine, Department of Internal Medicine, Aydin, Turkey.
authors.forename: Zahit
authors.initials: Z
authors.lastname: Bolaman
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D000078331:Correlation of Data; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000473:pathology; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL
keywords: Blood lipid profiles; Cholesterol levels; Chronic lymphocytic leukemia