title: Peniproline A, a new 1-phenylamino-2-pyrrolidone metabolite from the endophytic fungus Penicillium decumbens CP-4.
abstract: One new (named peniproline A, 1) and 11 known compounds were isolated from a culture of the endophytic fungus Penicillium decumbens CP-4. The structure of 1, featuring a phenylamine unit coupled with 2-pyrrolidone by forming a distinctive nitrogen-nitrogen bond, was elucidated based on extensive spectroscopic methods. Compound 1 was found to have cytotoxic effects against Bel-7402 and Hela cell lines with IC50values of 8.1 and 15.5 μM, respectively.
authors.affiliation: a Department of Biosynthetic Medicinal Chemistry, School of Pharmacy , Fudan University , Shanghai , PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Department of Biosynthetic Medicinal Chemistry, School of Pharmacy , Fudan University , Shanghai , PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: a Department of Biosynthetic Medicinal Chemistry, School of Pharmacy , Fudan University , Shanghai , PR China.
authors.forename: Shui
authors.initials: S
authors.lastname: Yu
authors.affiliation: a Department of Biosynthetic Medicinal Chemistry, School of Pharmacy , Fudan University , Shanghai , PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Ye
authors.affiliation: a Department of Biosynthetic Medicinal Chemistry, School of Pharmacy , Fudan University , Shanghai , PR China.
authors.forename: Meiqing
authors.initials: M
authors.lastname: Feng
authors.affiliation: a Department of Biosynthetic Medicinal Chemistry, School of Pharmacy , Fudan University , Shanghai , PR China.
authors.forename: Jiyang
authors.initials: J
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D060026:Endophytes / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D010407:Penicillium / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry* / Q000494:pharmacology; D011760:Pyrrolidinones / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D011759:Pyrrolidines; D011760:Pyrrolidinones; C000624638:peniproline A; C028537:2-pyrrolidone; D009584:Nitrogen
keywords: Penicillium decumbens; Peniproline A; cytotoxicity; endophytic fungus