title: Motion invariant contrast enhancement of optical imaging data in the gradient domain.
abstract: Functional optical imaging (OI) of intrinsic signals (like blood oxygenation coupled reflection changes) and of extrinsic properties of voltage sensitive probes (like voltage-sensitive dyes (VSD)) forms a group of neuroimaging techniques that possess up to date highest temporal and spatial resolution on a meso-to macroscopic scale. An inherent problem of OI is a very low signal to noise ratio (SNR), which restricts the recordings to be completely motionless and requires detailed knowledge of the properties of the different noise sources. In our experiments we performed a durectomy and did not use an imaging chamber to allow us future joint electroencephalography-optical imaging (EEG-OI) measures, which resulted in movement artifacts. With the goal of motion compensation in OI recordings and magnification of signal changes, we present a novel processing pipeline, which is based on optic flow guided denoising and gradient domain tone mapping for spatiotemporal contrast enhancement.
authors.forename: Philipp
authors.initials: P
authors.lastname: Flotho
authors.forename: Alejandro
authors.initials: A
authors.lastname: Romero-Santiago
authors.forename: Karsten
authors.initials: K
authors.lastname: Schwerdtfeger
authors.forename: Jacek
authors.initials: J
authors.lastname: Szczygielski
authors.forename: Matthias
authors.initials: M
authors.lastname: Hulser
authors.forename: Lars
authors.initials: L
authors.lastname: Haab
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Strauss
mesh_terms: D000818:Animals; D016477:Artifacts; D004569:Electroencephalography; D005123:Eye / Q000187:drug effects; D007091:Image Processing, Computer-Assisted; D009038:Motion; D009068:Movement; D059906:Neuroimaging; D061848:Optical Imaging; D051381:Rats; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D013003:Somatosensory Cortex / Q000473:pathology; D013997:Time Factors; D014664:Vasodilation