title: Downstaging of bilobar hepatocellular carcinoma after radioembolization with90Y microspheres as a bridge to liver transplantation.
abstract: Hepatic radioembolization with90Y is an increasingly widely used locoregional therapy in the treatment of hepatocellular carcinoma. Its potential benefit has recently been described as a downstaging treatment, achieving a decreased tumour burden and allowing patients to be rescued for more radical treatments, such as liver transplantation. The case is presented of a patient diagnosed with multifocal bilobar hepatocellular carcinoma, Barcelona Clinic Liver Cancer (BCLC) intermediate stage, in whom treatment with90Y achieved a satisfactory radiological response with a very significant reduction of tumour burden, allowing rescue with liver transplantation.
authors.affiliation: Servicio de Medicina Nuclear, Hospital General Universitario Gregorio Marañón, Madrid, España. Electronic address: Lreguerab@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Reguera-Berenguer
authors.affiliation: Servicio de Medicina Nuclear, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: Orcajo-Rincón
authors.affiliation: Servicio de Medicina Nuclear, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Rotger-Regí
authors.affiliation: Sección de Hepatología, Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: A M
authors.initials: AM
authors.lastname: Matilla-Peña
authors.affiliation: Sección de Radiología Intervencionista, Servicio de Radiodiagnóstico, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Echenagusia-Boyra
authors.affiliation: Servicio de Medicina Nuclear, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: R
authors.initials: R
authors.lastname: Pérez-Pascual
authors.affiliation: Servicio de Medicina Nuclear, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Marí-Hualde
authors.affiliation: Servicio de Medicina Nuclear, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: J C
authors.initials: JC
authors.lastname: Alonso-Farto
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D016031:Liver Transplantation; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D009367:Neoplasm Staging; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D015021:Yttrium Radioisotopes; C000615496:Yttrium-90
keywords: (90)Y microspheres; Carcinoma hepatocelular; Downstaging; Hepatocellular carcinoma; Intra-arterial therapy; Liver transplantation; Microesferas de (90)Y; Radioembolización con (90)Y; Radioembolization; Terapia intraarterial; Trasplante hepático