title: Therapeutic potentials of mesenchymal stem cells on the renal cortex of experimentally induced hypertensive albino rats: Relevant role of Nrf2.
abstract: Bone marrow derived-mesenchymal stem cells (BM-MSCs) have brought great attention in regenerative medicine field, various experimental & clinical trials were held to investigate their therapeutic effects in different disorders. We designed a histological & immunohistochemical study to evaluate effectiveness of MSCs therapy in withhold of end-stage renal disease (ESRD) secondary to hypertension which has become a growing & striking public health problem. 30 adult male albino rats were utilized, 20 of them were exposed to experimental induction of hypertension, then divided equally to MSCs treated group (injected with 1×106fluorescent labeled cell i.v./rat), while the second one was left without treatment. Renal specimens were subjected to histopathological, ultrastructural and immunohistochemical examination for Nrf2 in addition to biochemical estimation of serum urea & creatinine. Our results documented that BM-derived MSCs exerts considerable reversing effect of histopathologic and ultrastructural hypertensive nephropathy. Moreover, immunohistochemical results clearly pointed to relevant role of Nrf2 pathway in MSCs related renal therapeutic effects.
authors.affiliation: Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Egypt.
authors.forename: Eman M
authors.initials: EM
authors.lastname: Mohamed
authors.affiliation: Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Egypt. Electronic address: dr.maiamin@yahoo.com.
authors.forename: Mai A
authors.initials: MA
authors.lastname: Samak
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D006977:Hypertension, Renal / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D007668:Kidney / Q000166:cytology / Q000473:pathology; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051267:NF-E2-Related Factor 2 / Q000235:genetics*; D009393:Nephritis / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D051381:Rats
chemical_list: D051267:NF-E2-Related Factor 2; C495637:Nfe2l2 protein, rat
keywords: Hypertension; Nrf2; Renal cortex; Stem cells