title: Regulatory Role of N6-methyladenosine (m6A) Methylation in RNA Processing and Human Diseases.
abstract: N6-methyladenosine (m6A) modification is an abundant and conservative RNA modification in bacterial and eukaryotic cells. m6A modification mainly occurs in the 3' untranslated regions (UTRs) and near the stop codons of mRNA. Diverse strategies have been developed for identifying m6A sites in single nucleotide resolution. Dynamic regulation of m6A is found in metabolism, embryogenesis, and developmental processes, indicating a possible epigenetic regulation role along RNA processing and exerting biological functions. It has been known that m6A editing involves in nuclear RNA export, mRNA degradation, protein translation, and RNA splicing. Deficiency of m6A modification will lead to kinds of diseases, such as obesity, cancer, type 2 diabetes mellitus (T2DM), infertility, and developmental arrest. Some specific inhibitors against methyltransferase and demethylase have been developed to selectively regulate m6A modification, which may be advantageous for treatment of m6A related diseases. J. Cell. Biochem. 118: 2534-2543, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Laboratory of Cell Signal Transduction, Basic Medical School of Henan University, Kaifeng, Henan, 475004, China.|Department of Medical Microbiology, Basic Medical School of Henan University, Kaifeng, Henan, 475004, China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Wei
authors.affiliation: Department of Medical Microbiology, Basic Medical School of Henan University, Kaifeng, Henan, 475004, China.
authors.forename: Xinying
authors.initials: X
authors.lastname: Ji
authors.affiliation: Laboratory of Cell Signal Transduction, Basic Medical School of Henan University, Kaifeng, Henan, 475004, China.
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Guo
authors.affiliation: Laboratory of Cell Signal Transduction, Basic Medical School of Henan University, Kaifeng, Henan, 475004, China.|Department of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, 475001, China.
authors.forename: Shaoping
authors.identifier: 0000-0003-1078-1819
authors.initials: S
authors.lastname: Ji
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D008745:Methylation; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012334:RNA, Neoplasm / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D012334:RNA, Neoplasm; C010223:N-methyladenosine; D000241:Adenosine
keywords: DEMETHYLASE; HUMAN DISEASES; METHYLTRANSFERASE; RNA PROCESSING; m6A MODIFICATION