title: Ultra-fast line-field low coherence holographic elastography using spatial phase shifting.
abstract: Optical coherence elastography (OCE) is an emerging technique for quantifying tissue biomechanical properties. Generally, OCE relies on point-by-point scanning. However, long acquisition times make point-by-point scanning unfeasible for clinical use. Here we demonstrate a noncontact single shot line-field low coherence holography system utilizing an automatic Hilbert transform analysis based on a spatial phase shifting technique. Spatio-temporal maps of elastic wave propagation were acquired with only one air-pulse excitation and used to quantify wave velocity and sample mechanical properties at a line rate of 200 kHz. Results obtained on phantoms were correlated with data from mechanical testing. Finally, the stiffness of porcine cornea at different intraocular pressures was also quantifiedin situ.
authors.affiliation: Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas 77204, USA.
authors.forename: Chih-Hao
authors.initials: CH
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas 77204, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Schill
authors.affiliation: Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas 77204, USA.
authors.forename: Raksha
authors.initials: R
authors.lastname: Raghunathan
authors.affiliation: Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas 77204, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas 77204, USA.
authors.forename: Manmohan
authors.initials: M
authors.lastname: Singh
authors.affiliation: Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas 77204, USA.
authors.forename: Zhaolong
authors.initials: Z
authors.lastname: Han
authors.affiliation: Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas 77204, USA.
authors.forename: Achuth
authors.initials: A
authors.lastname: Nair
authors.affiliation: Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas 77204, USA; Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk, Russia; Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77584, USA.
authors.forename: Kirill V
authors.initials: KV
authors.lastname: Larin
keywords: (100.5070) Phase retrieval; (110.4500) Optical coherence tomography; (170.6935) Tissue characterization