title: There is something about BOK we just don't get yet.
abstract: Fernández-Marrero and colleagues show in their work that the proapoptotic BCL-2 family member BOK can form large, stable pores in artificial liposomes. This can be enhanced by the proapoptotic protein cBID and is unaffected by the antiapoptotic BCL-XL. Although BOK can bind to isolated mitochondria, it is unable to cause cytochrome c release even with the help of cBID.
authors.affiliation: Division of Developmental Immunology, BIOCENTER, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Manuel D
authors.initials: MD
authors.lastname: Haschka
authors.affiliation: Division of Developmental Immunology, BIOCENTER, Medical University of Innsbruck, Innsbruck, Austria.|Tyrolean Cancer Research Institute, Innsbruck, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Villunger
mesh_terms: D017209:Apoptosis; D045304:Cytochromes c; D008081:Liposomes; D008928:Mitochondria; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein
chemical_list: D008081:Liposomes; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein; D045304:Cytochromes c