title: Health-related quality of life in Black breast cancer survivors with and without triple-negative breast cancer (TNBC).
abstract: OBJECTIVE
  Black women are more likely to develop early-onset (≤50 years) breast cancer (BC) and have the lowest five-year, cause-specific survival rate of any United States (U.S.) racial or ethnic group. These disparities can be attributed partially to the higher rate of triple-negative BC (TNBC) in Blacks. Yet, little is known about health-related quality of life (HRQOL) among Black women with TNBC.
  
  
  METHODS
  Black women with invasive BC ≤ 50 years were recruited via the Florida Cancer Data System as part of a population-based case-only study of etiology and outcomes of early-onset invasive BC. Of 460 consented participants, a subset of 355 self-reported sociodemographic, clinical, and psychosocial variables. Descriptive analyses included participants with known TNBC (n = 85) or non-TNBC (n = 245) disease. Univariable and multivariable analyses were conducted to examine differences in factors associated with HRQOL.
  
  
  RESULTS
  In unadjusted analyses, TNBC participants had significantly lower FACT-B total scores (90.1 ± 27.9) compared to non-TNBC (98.5 ± 27.6) participants (p < 0.05). For the TNBC group, multivariable analyses indicated five individual-level, and three systemic-level factors explain 80% of the response variation in HRQOL. For the non-TNBC group, seven individual-level factors and three systemic-level factors account for 76% of the variation in HRQOL scores.
  
  
  CONCLUSIONS
  Compared to Black women with non-TNBC, TNBC women have worse HRQOL. There are key individual and systemic-level factors that are unique to both groups. Findings can inform future HRQOL interventions to support young Black BC survivors.
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, MRC-CANCONT, Tampa, FL, 33612, USA. susan.vadaparampil@moffitt.org.
authors.forename: Susan T
authors.initials: ST
authors.lastname: Vadaparampil
authors.affiliation: University of Maryland, 4200 Valley Drive, Room 1242W, College Park, MD, 20742, USA.
authors.forename: Juliette
authors.initials: J
authors.lastname: Christie
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, MRC-CANCONT, Tampa, FL, 33612, USA.
authors.forename: Kristine A
authors.initials: KA
authors.lastname: Donovan
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, MRC-CANCONT, Tampa, FL, 33612, USA.
authors.forename: Jongphil
authors.initials: J
authors.lastname: Kim
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, MRC-CANCONT, Tampa, FL, 33612, USA.
authors.forename: Bianca
authors.initials: B
authors.lastname: Augusto
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, MRC-CANCONT, Tampa, FL, 33612, USA.
authors.forename: Monica L
authors.initials: ML
authors.lastname: Kasting
authors.affiliation: University of Maryland, 4200 Valley Drive, Room 1242W, College Park, MD, 20742, USA.
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Holt
authors.affiliation: City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA.
authors.forename: Kimlin
authors.initials: K
authors.lastname: Ashing
authors.affiliation: Medical University of South Carolina, 68 President Street, Charleston, SC, 29425, USA.
authors.forename: Chanita Hughes
authors.initials: CH
authors.lastname: Halbert
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, MRC-CANCONT, Tampa, FL, 33612, USA.
authors.forename: Tuya
authors.initials: T
authors.lastname: Pal
mesh_terms: D000328:Adult; D001741:Black or African American; D000073116:Cancer Survivors; D005260:Female; D006801:Humans; D008875:Middle Aged; D011788:Quality of Life; D064726:Triple Negative Breast Neoplasms / Q000523:psychology* / Q000628:therapy; D014481:United States
keywords: Black women; Breast cancer; Quality of life; Triple-negative breast cancer