title: Early management of acute pancreatitis: A review of the best evidence.
abstract: In the 20th century early management of acute pancreatitis often included surgical intervention, despite overwhelming mortality. The emergence of high-quality evidence (randomized controlled trials and meta-analyses) over the past two decades has notably shifted the treatment paradigm towards predominantly non-surgical management early in the course of acute pancreatitis. The present evidence-based review focuses on contemporary aspects of early management (which include analgesia, fluid resuscitation, antibiotics, nutrition, and endoscopic retrograde cholangiopancreatography) with a view to providing clear and succinct guidelines on early management of patients with acute pancreatitis in 2017 and beyond.
authors.affiliation: Digestive & Liver Disease Unit, S. Andrea Hospital, University "La Sapienza", Rome, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Stigliano
authors.affiliation: Department of Surgery, Institution of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
authors.forename: Hanna
authors.initials: H
authors.lastname: Sternby
authors.affiliation: Department of Gastroenterology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: de Madaria
authors.affiliation: Digestive & Liver Disease Unit, S. Andrea Hospital, University "La Sapienza", Rome, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Capurso
authors.affiliation: Department of Surgery, University of Auckland, Auckland, New Zealand. Electronic address: max.petrov@gmail.com.
authors.forename: Maxim S
authors.initials: MS
authors.lastname: Petrov
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002760:Cholangiopancreatography, Endoscopic Retrograde; D019468:Disease Management; D004750:Enteral Nutrition; D055317:Evidence-Based Practice; D005440:Fluid Therapy; D006801:Humans; D059408:Pain Management; D010195:Pancreatitis / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000900:Anti-Bacterial Agents
keywords: Acute pancreatitis; Antibiotics; Endoscopic treatment; Enteral feeding; Fluid resuscitation; Pain management