title: Therapeutic mechanism of Yīn-Chén-Hāo decoction in hepatic diseases.
abstract: Yīn-Chén-Hāo decoction (YCHD) is a traditional Chinese medicine formula composed of capillaris (Artemisia capillaris), gardenia (Gardenia jasminoides), and rhubarb (Rheum rhabarbarum) that is used for the treatment of damp-heat jaundice. In modern clinics, YCHD is mostly used for hepatic diseases. This review summarizes the biological activities of YCHD and its medical applications. The main active compounds of YCHD are chlorogenic acid, rhein, geniposide, emodin, and scoparone. The pharmacological actions of YCHD include inhibition of hepatic steatosis, apoptosis, necrosis, anti-inflammation, and immune regulation. YCHD could be developed as a new therapeutic strategy for the treatment of hepatic diseases.
authors.affiliation: Jian-Yuan Li, Hong-Yan Cao, Run-Fei Sun, Chao Wu, Yan-Qin Bian, Shu Dong, Ping Liu, Ming-Yu Sun, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Jian-Yuan
authors.initials: JY
authors.lastname: Li
authors.affiliation: Jian-Yuan Li, Hong-Yan Cao, Run-Fei Sun, Chao Wu, Yan-Qin Bian, Shu Dong, Ping Liu, Ming-Yu Sun, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Cao
authors.affiliation: Jian-Yuan Li, Hong-Yan Cao, Run-Fei Sun, Chao Wu, Yan-Qin Bian, Shu Dong, Ping Liu, Ming-Yu Sun, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.affiliation: Jian-Yuan Li, Hong-Yan Cao, Run-Fei Sun, Chao Wu, Yan-Qin Bian, Shu Dong, Ping Liu, Ming-Yu Sun, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Run-Fei
authors.initials: RF
authors.lastname: Sun
authors.affiliation: Jian-Yuan Li, Hong-Yan Cao, Run-Fei Sun, Chao Wu, Yan-Qin Bian, Shu Dong, Ping Liu, Ming-Yu Sun, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wu
authors.affiliation: Jian-Yuan Li, Hong-Yan Cao, Run-Fei Sun, Chao Wu, Yan-Qin Bian, Shu Dong, Ping Liu, Ming-Yu Sun, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Yan-Qin
authors.initials: YQ
authors.lastname: Bian
authors.affiliation: Jian-Yuan Li, Hong-Yan Cao, Run-Fei Sun, Chao Wu, Yan-Qin Bian, Shu Dong, Ping Liu, Ming-Yu Sun, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Dong
authors.affiliation: Jian-Yuan Li, Hong-Yan Cao, Run-Fei Sun, Chao Wu, Yan-Qin Bian, Shu Dong, Ping Liu, Ming-Yu Sun, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: Jian-Yuan Li, Hong-Yan Cao, Run-Fei Sun, Chao Wu, Yan-Qin Bian, Shu Dong, Ping Liu, Ming-Yu Sun, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Sun
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D019306:Artemisia / Q000737:chemistry; D001201:Ascites / Q000188:drug therapy; D002726:Chlorogenic Acid / Q000737:chemistry; D002986:Clinical Trials as Topic; D003374:Coumarins / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004642:Emodin / Q000737:chemistry; D005234:Fatty Liver / Q000188:drug therapy; D032062:Gardenia / Q000737:chemistry; D006801:Humans; D039823:Iridoids / Q000737:chemistry; D008107:Liver Diseases / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use; D012250:Rheum / Q000737:chemistry
chemical_list: D000880:Anthraquinones; D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D039823:Iridoids; D010936:Plant Extracts; C542425:yin-chen-hao-tang; C007835:geniposide; D002726:Chlorogenic Acid; C018145:scoparone; D004642:Emodin; C020491:rhein
keywords: Clinical application; Effector mechanism; Hepatic disease; Review; Yīn-Chén-Hāo decoction