title: Pediatric bladder/prostate rhabdomyosarcoma: Eight cases from a single center.
abstract: In this study, clinical characteristics, treatment modalities and outcome of patients diagnosed with bladder/prostate rhabdomyosarcoma (BP RMS) were evaluated retrospectively. Files of 8 children diagnosed with BP RMS and treated between 2004-2014 were reviewed for clinical characteristics, treatment modalities and outcome. Seven males and one female were diagnosed with BP RMS between 2004-2014. Median age was 33.5 months (range, 2 to 176 months). At presentation the main clinical symptoms were hematuria in 5 patients, and constipation, oliguria and prolonged jaundice in 1 patient each. All patients were non-metastatic and only one had an embryonal histology. Primary resection before chemotherapy was performed on only one patient. Six patients were treated initially with VAC chemotherapy for 12 weeks, two patients were treated PIAV (ifosfamide, cisplatin, doxorubicin, vincristine). Local relapse or progressive disease occurred in 5 of 8 patients, and two of these patients underwent primary or secondary tumor resection without radiotherapy. Three patients developed a local relapse after combination of radiochemotherapy and tumor resection. Radical surgical treatment was performed in 3 patients with local relapse. Only one patient underwent partial cystectomy. Six of 8 patients were alive and under follow-up without disease at a median survival of 53 months (range, 13 to 78 months). BP RMS requires a multidisciplinary treatment approach. There is a general consensus that chemotherapy is the mainstay of treatment in BP RMS, but the method to be used for local control is controversial, and may vary from case to case in this heterogeneous disease.
authors.affiliation: Departments of Pediatric Oncology, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Emir
authors.affiliation: Department of Pediatric Oncology, Yıldırım Beyazıt University Faculty of Medicine; Ankara, Turkey.
authors.forename: Sonay İncesoy
authors.initials: Sİ
authors.lastname: Özdemir
authors.affiliation: Departments of Pediatric Oncology, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Hacı Ahmet
authors.initials: HA
authors.lastname: Demir
authors.affiliation: Departments of Pediatric Oncology, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Özyörük
authors.affiliation: Departments of Pathology, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Karakuş
authors.affiliation: Departments of Pediatric Surgery, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Tuğrul
authors.initials: T
authors.lastname: Tiryaki
authors.affiliation: Department of Radiation Oncology, Ankara Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Faik
authors.initials: F
authors.lastname: Çetindağ
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D059248:Chemoradiotherapy / Q000379:methods; D002648:Child; D002675:Child, Preschool; D015653:Cystectomy / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009364:Neoplasm Recurrence, Local; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000628:therapy; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000628:therapy*; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy
keywords: bladder; children; prostate; rhabdomyosarcoma; treatment