title: Modified Fluorodeoxyglucose Metabolism in Motor Circuitry by Subthalamic Deep Brain Stimulation.
abstract: Adjustment of the motor circuitry has been described in the treatment of Parkinson disease (PD).
  
  
  
  To evaluate the modulation of the motor circuitry of PD patients by subthalamic deep brain stimulation (STN DBS) using 18F-fluorodeoxyglucose (FDG) and positron emission tomography (PET).
  
  
  
  Resting-state brain 18F-FDG PET imaging was performed for 8 PD patients before surgery and also 1 year after STN DBS treatment; changes in regional glucose metabolism were identified. The PD-related pattern (PDRP) of metabolic covariation was also evaluated. In addition, the correlations between glucose metabolism and clinical alleviation were determined.
  
  
  
  Pronounced elevations in parietal and occipital glucose metabolism due to STN DBS modification were found; an obvious reduction in caudate, putamen, cerebellum, and frontal cortex glucose metabolism was detected after STN DBS interventions. The alleviation of rigidity correlated with an increment in glucose metabolism in the parietal lobe. STN DBS inhibited the PDRP; the decrease in the PDRP correlated with the inhibition of the glucose metabolism of the caudate and the augmented glucose metabolism of the occipital lobe.
  
  
  
  STN DBS modulates cortical function through the cortical-striatothalamocortial motor circuitry and cerebellothalamocortical motor circuitry.
authors.affiliation: Department of Functional Neurosurgery, Afﬁliated Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Cao
authors.forename: Huiwei
authors.initials: H
authors.lastname: Zhang
authors.forename: Dianyou
authors.initials: D
authors.lastname: Li
authors.forename: Shikun
authors.initials: S
authors.lastname: Zhan
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Zhang
authors.forename: Chuantao
authors.initials: C
authors.lastname: Zuo
authors.forename: Bomin
authors.initials: B
authors.lastname: Sun
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000378:metabolism*; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000601:surgery; D049268:Positron-Emission Tomography / Q000379:methods; D020531:Subthalamic Nucleus / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000601:surgery
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Deep brain stimulation; Motor circuitry; Parkinson disease; Positron emission tomography; Subthalamic nucleus