title: A new case of "de novo" BRCA1 mutation in a patient with early-onset breast cancer.
abstract: Most of the de novo BRCA1/2 mutations have been identified in patients with early-onset breast cancer and without family history of the disease. The identification of these alterations could play a prominent role in the prevention and treatment strategies and may influence clinical management of patients.
authors.affiliation: Laboratory of Molecular Genetics Department of Psychological, Health and Territorial Sciences (DISPUTer) School of Medicine and Health Sciences"G. d'Annunzio" University Chieti-Pescara Italy; CESI-Met Research Center"G. d'Annunzio" University Chieti Italy.
authors.forename: Ivana
authors.initials: I
authors.lastname: Antonucci
authors.affiliation: Laboratory of Molecular Genetics Department of Psychological, Health and Territorial Sciences (DISPUTer) School of Medicine and Health Sciences "G. d'Annunzio" University Chieti-Pescara Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Provenzano
authors.affiliation: Laboratory of Molecular Genetics Department of Psychological, Health and Territorial Sciences (DISPUTer) School of Medicine and Health Sciences "G. d'Annunzio" University Chieti-Pescara Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Sorino
authors.affiliation: Laboratory of Molecular Genetics Department of Psychological, Health and Territorial Sciences (DISPUTer) School of Medicine and Health Sciences "G. d'Annunzio" University Chieti-Pescara Italy.
authors.forename: Melissa
authors.initials: M
authors.lastname: Rodrigues
authors.affiliation: Department of Medical, Oral and Biotechnological Sciences School of Medicine and Health Sciences "G. d'Annunzio" University Chieti-Pescara Italy.
authors.forename: Giandomenico
authors.initials: G
authors.lastname: Palka
authors.affiliation: Laboratory of Molecular Genetics Department of Psychological, Health and Territorial Sciences (DISPUTer) School of Medicine and Health Sciences"G. d'Annunzio" University Chieti-Pescara Italy; CESI-Met Research Center"G. d'Annunzio" University Chieti Italy.
authors.forename: Liborio
authors.initials: L
authors.lastname: Stuppia
keywords: BRCA2 gene; breast cancer; de novo mutation; early onset