title: Midline Capillary Formation Nuchae and Age.
abstract: Midline capillary formation nuchae (MCFN) consists of blanchable pink macules located around the midline of the occiput and nape. It has been implicated in the literature as a risk factor for angiosarcoma and might be related to a decrease in innervation of the involved capillaries. Although there is ample literature on its prevalence from birth through adult life, the literature in late life is sparse. The objective of this study was to determine the prevalence in late life, whether it is truly a risk factor for angiosarcoma and whether it might be an indication of a systemic neuroendocrine effect or a local reaction. In routine skin screening examinations of 411 patients, the prevalence of MCFN increased with age (P<.0001), by quartiles of age overall (P=.0001), and among men only (P=.0013). No difference in prevalence was observed across quartiles of age among women only (P=.0688). No association was found with routine parameters that might be influenced by the systemic neuroendocrine system. Prevalence increases in old age, is not a risk factor for angiosarcoma, and might represent a response of local capillaries to normal changes in the neuroendocrine system that occur with age.
authors.affiliation: Department of Dermatology, Southern California Permanente Medical Group, Woodland Hills, CA; marvinklapman@gmail.com.
authors.forename: Marvin H
authors.initials: MH
authors.lastname: Klapman
authors.affiliation: Department of Research and Evaluation, Southern California Permanente Medical Group, Woodland Hills, CA.
authors.forename: Michael
authors.initials: M
authors.lastname: Batech
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D002196:Capillaries / Q000000981:diagnostic imaging / Q000254:growth & development*; D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009333:Neck / Q000098:blood supply*; D048208:Nuchal Translucency Measurement; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012737:Sex Factors