title: Long-term outcomes of high dose treatment and autologous stem cell transplantation in follicular and mantle cell lymphomas - a single centre experience.
abstract: BACKGROUND
  Advanced follicular lymphoma (FL) and mantle cell lymphoma (MCL) are incurable diseases with conventional treatment. The high dose treatment (HDT) with autologous stem cell transplantation (ASCT), however, offers a certain proportion of these patients the prospect of a prolonged disease-free and overall survival. The aim of this study was to investigate the event free survival (EFS) and overall survival (OS) in patients with FL and MCL treated with ASCT.
  
  
  METHODS
  Seventeen patients with FL and 29 patients with MCL were included, 15 of them were transplanted to consolidate the response to second line treatment and 24 to consolidate their first remission, respectively. All were conditioned with total body irradiation (TBI) and high dose cyclophosphamide between 2006 and 2014 and all were transplanted with peripheral blood stem cells.
  
  
  RESULTS
  The estimated 5-year OS for FL was 87.8% (95% confidence interval [CI] 59.5%-96.8%) and for MCL 79.3% (95% CI 56.1%-91.1%), respectively. The estimated 5-year EFS for FL was 76.0% (95% CI 48.0%-90.3%) and for MCL 69.8% (95% CI 45.5%-84.8%), respectively. There were no secondary hematological malignancies observed in either group.
  
  
  CONCLUSIONS
  Based on above results, the ASCT with TBI is a good treatment option in terms of long-term survival for patients with follicular and mantle cell lymphoma demonstrating a relatively low rate of late toxicities and secondary malignancies.
authors.affiliation: Department of Medical Oncology, Institute of Oncology Ljubljana, Slovenia.
authors.forename: Lucka
authors.initials: L
authors.lastname: Boltezar
authors.affiliation: Faculty of Medicine, University of Ljubljana, Slovenia.
authors.forename: Karlo
authors.initials: K
authors.lastname: Pintaric
authors.affiliation: Department of Hematology, University Clinical Centre Ljubljana, Slovenia.
authors.forename: Jože
authors.initials: J
authors.lastname: Pretnar
authors.affiliation: Department of Biostatistics and Medical Informatics, University of Ljubljana, Slovenia.
authors.forename: Maja
authors.initials: M
authors.lastname: Pohar Perme
authors.affiliation: Department of Medical Oncology, Institute of Oncology Ljubljana, Slovenia.
authors.forename: Barbara Jezersek
authors.initials: BJ
authors.lastname: Novakovic
keywords: autologous stem cell transplantation; follicular lymphoma; hematological malignancies; mantle cell lymphoma; overall survival