title: Female sexual dysfunction in androgenetic alopecia: Case-control study.
abstract: BACKGROUND
  We sought to evaluate the association of female sexual dysfunction (FSD) with androgenetic alopecia (AGA) and metabolic syndrome (MetS) in premenopausal women.
  
  
  METHODS
  From December 2013 to June 2015, we performed a case-control, prospective study of 115 patients with AGA and 97 age-matched control patients without AGA from among premenopausal women who visited dermatology clinics of the two reference hospitals. Comprehensive history, anthropometric measurements, and questionnaire administration were performed for each of the total of 212 women. The Female Sexual Function Index (FSFI) was used to assess the key dimensions of female sexual function. AGA was assessed and graded by an experienced dermatologist according to Ludwig's classification. The MetS assessment was made according to the NCEP-ATP III criteria.
  
  
  RESULTS
  In univariate analysis, age, weight, waist circumference, hip circumference, waist-to-hip ratio, body mass index (BMI), AGA, MetS, cardiovascular event, marital status, hypertension, high fasting plasma glucose, high triglyceride, large waist, total testosterone, and free testosterone were associated with presence of FSD. In logistic regression analysis, age (odds ratio [OR] 1.21, 95% confidence interval [CI] 1.13-1.30; p<0.001), AGA (OR 3.42, 95% CI 1.31-8.94; p=0.017), MetS (OR 5.39, 95% CI 1.34-21.62; p=0.012), and free testosterone (OR 0.18, 95% CI 0.09-0.37; p<0.001) were independently associated with FSD.
  
  
  CONCLUSIONS
  Our study suggests that age, AGA, MetS, and free testosterone may have strong impact on sexual function in premenopausal women. Further studies with population-based and longitudinal design should be conducted to confirm this finding.
authors.affiliation: Department of Urology, Canakkale Onsekiz Mart University, Faculty of Medicine, Canakkale, Turkey.
authors.forename: Eyup Burak
authors.initials: EB
authors.lastname: Sancak
authors.affiliation: Department of Dermatology, Canakkale Onsekiz Mart University, Faculty of Medicine, Canakkale, Turkey.
authors.forename: Sevilay
authors.initials: S
authors.lastname: Oguz
authors.affiliation: Department of Dermatology, Haseki Training and Research Hospital, Istanbul, Turkey.
authors.forename: Tugba
authors.initials: T
authors.lastname: Akbulut
authors.affiliation: Department of Family Medicine, Canakkale Onsekiz Mart University, Faculty of Medicine, Canakkale, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Uludag
authors.affiliation: Department of Urology, Canakkale Onsekiz Mart University, Faculty of Medicine, Canakkale, Turkey.
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Akbas
authors.affiliation: Department of Urology, Namık Kemal University, Faculty of Medicine, Tekirdag, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Kurt
authors.affiliation: Department of Urology, Haseki Training and Research Hospital, Istanbul, Turkey.
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Akbulut