title: Fabricating biomedical origami: a state-of-the-art review.
abstract: OBJECTIVE
  Origami-based biomedical device design is an emerging technology due to its ability to be deployed from a minimal foldable pattern to a larger volume. This paper aims to review state-of-the-art origami structures applied in the medical device field.
  
  
  METHODS
  Publications and reports of origami structure related to medical device design from the past 10 years are reviewed and categorized according to engineering specifications, including the application field, fabrication material, size/volume, deployment method, manufacturability, and advantages.
  
  
  RESULTS
  This paper presents an overview of the biomedical applications of devices based on origami structures, including disposable sterilization covers, cardiac catheterization, stent grafts, encapsulation and microsurgery, gastrointestinal microsurgery, laparoscopic surgical grippers, microgrippers, microfluidic devices, and drug delivery. Challenges in terms of materials and fabrication, assembly, modeling and computation design, and clinical adoptability are discussed at the end of this paper to provide guidance for future origami-based design in the medical device field.
  
  
  CONCLUSIONS
  Concepts from origami can be used to design and develop novel medical devices. Origami-based medical device design is currently progressing, with researchers improving design methods, materials, fabrication techniques, and folding efficiency.
authors.affiliation: College of Engineering, The University of Georgia, Athens, GA, 30605, USA.
authors.forename: Meredith
authors.initials: M
authors.lastname: Johnson
authors.affiliation: College of Engineering, The University of Georgia, Athens, GA, 30605, USA.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.affiliation: College of Engineering, The University of Georgia, Athens, GA, 30605, USA.
authors.forename: Sierra
authors.initials: S
authors.lastname: Hovet
authors.affiliation: National Institutes of Health, Bethesda, MD, USA.
authors.forename: Sheng
authors.initials: S
authors.lastname: Xu
authors.affiliation: National Institutes of Health, Bethesda, MD, USA.
authors.forename: Bradford
authors.initials: B
authors.lastname: Wood
authors.affiliation: Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Ren
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Junichi
authors.initials: J
authors.lastname: Tokuda
authors.affiliation: College of Engineering, The University of Georgia, Athens, GA, 30605, USA. ziontse@uga.edu.
authors.forename: Zion Tsz Ho
authors.initials: ZTH
authors.lastname: Tse
mesh_terms: D001672:Biocompatible Materials; D006328:Cardiac Catheterization / Q000295:instrumentation; D004867:Equipment Design; D006801:Humans; D010535:Laparoscopy / Q000295:instrumentation; D008866:Microsurgery / Q000295:instrumentation; D013523:Surgical Equipment
chemical_list: D001672:Biocompatible Materials
keywords: Biomaterials.; Biomedical; Origami; Paper folding; Surgical