title: Synthesis of the KLMN Fragment of Gymnocin-A from the FGH Fragment.
abstract: An improved route for the synthesis of the KLMN fragment of gymnocin-A was developed through the oxiranyl anion coupling of the FGH fragment with a chiral C3epoxy sulfone, followed by 6-endo cyclization. This straightforward approach reduced the number of synthetic steps by 14 compared with a previous route using alternative building blocks.
authors.affiliation: Faculty of Pharmacy, Meijo University , 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.
authors.forename: Takeo
authors.identifier: 0000-0002-9006-8249
authors.initials: T
authors.lastname: Sakai
authors.affiliation: Faculty of Pharmacy, Meijo University , 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.
authors.forename: Aoi
authors.initials: A
authors.lastname: Ishihara
authors.affiliation: Faculty of Pharmacy, Meijo University , 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mori
mesh_terms: D003500:Cyclization; D004988:Ethers, Cyclic / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D004988:Ethers, Cyclic; C458159:gymnocin A