title: 17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester from Streptomyces sp. SR107.
abstract: A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester (1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on the basis of its spectral data (1H NMR,13C NMR,1H-1H COSY, HSQC, HMBC, NOESY, IR and HR-ESI-MS). The antibacterial activity was also evaluated in this paper.
authors.affiliation: Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors.forename: Meng-Yu-Jie
authors.initials: MY
authors.lastname: Liu
authors.affiliation: Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors.forename: Shan-Ren
authors.initials: SR
authors.lastname: Li
authors.affiliation: Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address: ahua0966@sdu.edu.cn.
authors.forename: L U
authors.initials: LU
authors.lastname: Chun-Hua
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D004952:Esters / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry*
chemical_list: C588368:16,17-dihydroxycyclooctatin; D000900:Anti-Bacterial Agents; D004224:Diterpenes; D004952:Esters
keywords: 17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester; Antibacterial activity; Diterpenes; Streptomyces sp. SR107