title: Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats.
abstract: It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action of classical benzodiazepine drugs. To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test. We found that, even in the absence of chronic stress, the administration of a course of test substances changed anxiety indicators toward their deterioration, but the changes after the administration of a course of Selank were less pronounced. In conditions of chronic stress, anxiety indicator values after the simultaneous use of diazepam and Selank did not differ from the respective values observed before chronic stress exposure. The data obtained indicate that the individual administration of Selank was the most effective in reducing elevated levels of anxiety, induced by the administration of a course of test substances, whereas the combination of diazepam with Selank was the most effective in reducing anxiety in unpredictable chronic mild stress conditions.
authors.affiliation: Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
authors.forename: Anastasiya
authors.identifier: 0000-0002-4882-7600
authors.initials: A
authors.lastname: Kasian
authors.affiliation: Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
authors.forename: Timur
authors.initials: T
authors.lastname: Kolomin
authors.affiliation: Department of Chemistry of Physiologically Active Compounds, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
authors.forename: Lyudmila
authors.initials: L
authors.lastname: Andreeva
authors.affiliation: Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Bondarenko
authors.affiliation: Department of Chemistry of Physiologically Active Compounds, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
authors.forename: Nikolay
authors.initials: N
authors.lastname: Myasoedov
authors.affiliation: Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
authors.forename: Petr
authors.initials: P
authors.lastname: Slominsky
authors.affiliation: Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
authors.forename: Maria
authors.initials: M
authors.lastname: Shadrina
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy*; D003975:Diazepam / Q000494:pharmacology*; D004195:Disease Models, Animal; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000187:drug effects*
chemical_list: D014151:Anti-Anxiety Agents; D009842:Oligopeptides; D010455:Peptides; D003975:Diazepam; C100827:TP 7