title: Kerato-lenticular ocular deposits and visual impairment with prolonged chlorpromazine use: A case series.
abstract: Chlorpromazine is a low potency "typical" antipsychotic agent used to treat schizophrenia. It continues to be prescribed frequently in India owing to its lower cost. There have been previous reports of ocular adverse effects with prolonged use of chlorpromazine. We report three patients who developed corneal and lenticular opacities secondary to prolonged chlorpromazine use leading to visual impairment. Early detection of ocular deposits and switching over to risperidone from chlorpromazine helped in the reversal of chlorpromazine- induced ocular side effects in one of them. The case series further adds evidence to the causative relationship between chlorpromazine and ocular side effects.
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, 560029, India. Electronic address: drgsgowda@gmail.com.
authors.forename: Guru S
authors.initials: GS
authors.lastname: Gowda
authors.affiliation: Northwest Mental Health, Victoria, Australia.
authors.forename: Aditya
authors.initials: A
authors.lastname: Hegde
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, 560029, India.
authors.forename: Vandita
authors.initials: V
authors.lastname: Shanbhag
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, 560029, India.
authors.forename: Janardhanan C
authors.initials: JC
authors.lastname: Narayanaswamy
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, 560029, India.
authors.forename: T S
authors.initials: TS
authors.lastname: Jaisoorya
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D002386:Cataract / Q000139:chemically induced*; D002746:Chlorpromazine / Q000009:adverse effects*; D003315:Cornea / Q000473:pathology; D005260:Female; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000178:diet therapy / Q000188:drug therapy*; D014786:Vision Disorders / Q000139:chemically induced*
chemical_list: D014150:Antipsychotic Agents; D002746:Chlorpromazine
keywords: Cataract; Chlorpromazine; Corneal deposits; Switch over; Visual impairment