title: A new flavonoid from Sophora flavescens Ait.
abstract: A new flavonoid, 8-(3-hydroxymethyl-2-butenyl)-5,7,2',4'-tetrahydroxyflavanone (1), along with seven known compounds, (2R)-3α,7,4'-Trihydroxy -5-methoxy-8-prenylflavanone (2), (2R)-3β,7,4'- Trihydroxy-5-methoxy-8-prenylflavanone (3), 3,7-dihydroxycoumarin (4), Shandougenines B (5), Specionin (6), Kushenol N (7) and Kushenol I (8) were isolated from the roots of Sophora flavescens. Among them, Compound 5 was isolated from Leguminous plants, and compounds 4 and 6 were isolated from Sophora flavescens for the first time. Their structures were elucidated by the aid of NMR, HRMS, HMBC and CD spectroscopic methods.
authors.affiliation: a Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, College of Traditional Chinese Materia Medica , Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.affiliation: b School of Chinese Medicine , Southern Medical University , Guangzhou , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, College of Traditional Chinese Materia Medica , Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Zhao
authors.affiliation: a Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, College of Traditional Chinese Materia Medica , Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Xi-Xin
authors.initials: XX
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, College of Traditional Chinese Materia Medica , Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: c Department of Pharmacy , Hunan University of Medicine , Huaihua , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cai
authors.affiliation: a Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, College of Traditional Chinese Materia Medica , Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
mesh_terms: D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D029909:Sophora / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D005419:Flavonoids
keywords: Sophora flavescens; isolation; structural identification