title: Advanced Heart Failure Therapies for Cancer Therapeutics-Related Cardiac Dysfunction.
abstract: End-stage heart failure in cancer survivors may result from cardiotoxic chemotherapy and/or chest radiation and require advanced therapies, including left ventricular assist devices (LVADs) and transplantation. Traditionally, such therapies have been underutilized in cancer survivors owing to lack of experience and perceived risk of cancer recurrence. Recent data from large registries, however, have shown excellent outcomes of LVADs and transplantation in cancer survivors, albeit subject to careful selection and special considerations. This article summarizes all aspects of advanced heart failure therapies in patients with cancer therapy-related cardiac dysfunction and underscores the need for careful selection of these candidates.
authors.affiliation: Onco-Cardiology Program, Advanced Heart Failure & Transplantation Center, Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Bianco
authors.affiliation: Onco-Cardiology Program, Advanced Heart Failure & Transplantation Center, Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
authors.forename: Sadeer G
authors.initials: SG
authors.lastname: Al-Kindi
authors.affiliation: Onco-Cardiology Program, Advanced Heart Failure & Transplantation Center, Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: guilherme.oliveira@uhhospitals.org.
authors.forename: Guilherme H
authors.initials: GH
authors.lastname: Oliveira
mesh_terms: D058406:Cardiac Resynchronization Therapy; D005260:Female; D006333:Heart Failure / Q000209:etiology / Q000628:therapy*; D016027:Heart Transplantation; D006352:Heart Ventricles / Q000503:physiopathology*; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000628:therapy*; D018579:Patient Selection; D012042:Registries; D016277:Ventricular Function, Left / Q000187:drug effects / Q000528:radiation effects; D016278:Ventricular Function, Right / Q000187:drug effects / Q000528:radiation effects
keywords: Anthracyclines; Cancer therapeutics–related cardiac dysfunction; Cardiac resynchronization therapy; Chemotherapy-induced cardiomyopathy; Heart failure; Heart transplant; Mechanical circulatory support devices; Right ventricular failure