title: Effect of Food Thickener on the Inhibitory Effect of Mitiglinide Tablets on Post-prandial Elevation of Blood Glucose Levels.
abstract: The aim of this study was to examine the effect of food thickener on the pharmacodynamics of mitiglinide (MGN), a drug belonging to a class of rapid-acting insulin secretagogues. First, MGN tablets were coated by immersion in a xanthan gum-based food-thickening agent. This treatment was shown to delay disintegration rates of MGN tablets in vitro. The pharmacodynamics of MGN after ingestion of a single oral dose of an MGN tablet, with or without food thickener immersion, were then examined in an open-label crossover study comprising 5 healthy participants. It was observed that after administration of 75 g of oral glucose, the area under the blood glucose concentration-time curve was larger for treatment with MGN tablets that had been immersed in the food thickener than for nonimmersed tablets. The maximum blood glucose level was also higher in treatments with MGN tablets that had been immersed in food thickener. The extended time of higher glucose levels associated with thickener-immersed MGN tablets given to human volunteers may be associated with the reduced disintegration rates of immersed MGN tablets as observed in the in vitro experiment. Overall, our study suggests that commercially available food thickeners influence the pharmacodynamics of MGN and that their use should therefore be carefully assessed and monitored in certain clinical situations.
authors.affiliation: Department of Clinical Pharmaceutics and Pharmacy Practice, School of Pharmacy, Iwate Medical University, 2-1-1, Nishitokuta, Yahabacho, Shiwagun, Morioka, Iwate, 028-3694, Japan. tatomita@iwate-med.ac.jp.|Department of Pharmacy, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515, Japan. tatomita@iwate-med.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tomita
authors.affiliation: Department of Pharmacy, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Goto
authors.affiliation: Faculty of Pharmacy, Iwaki Meisei University, 5-5-1 Chuodai Iino, Iwaki, Fukushima, 970-8551, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Sumiya
authors.affiliation: Department of Internal Medicine, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshida
authors.affiliation: Department of Psychiatry, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Department of Clinical Pharmaceutics and Pharmacy Practice, School of Pharmacy, Iwate Medical University, 2-1-1, Nishitokuta, Yahabacho, Shiwagun, Morioka, Iwate, 028-3694, Japan.
authors.forename: Kenzo
authors.initials: K
authors.lastname: Kudo
authors.affiliation: Department of Pharmacy, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515, Japan.|Faculty of Health Sciences, Tsukuba International University, 6-20-1 Manabe, Tsuchiura, Ibaraki, 300-0051, Japan.
authors.forename: Yukinao
authors.initials: Y
authors.lastname: Kohda
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D004435:Eating / Q000502:physiology; D005260:Female; D005503:Food Additives / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D054833:Isoindoles / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology
chemical_list: D001786:Blood Glucose; D005503:Food Additives; D007004:Hypoglycemic Agents; D054833:Isoindoles; C087255:mitiglinide
keywords: Blood glucose level; Deglutition; Deglutition disorders; Food thickener; Mitiglinide; Post-prandial elevation