title: Sex hormone binding globulin as a valuable biochemical marker in predicting gestational diabetes mellitus.
abstract: Circulating Sex hormone binding globulin (SHBG) levels are inversely associated with insulin resistance. This study was conducted to compare maternal serum SHBG level between pregnant women with normal glucose tolerance and those with gestational diabetes (GDM) and to investigate the roll of SHBG in GDM diagnosis.
  
  
  
  This was a case controlled study of 90 pregnant women, 45 women with GDM and 45 matched controls, attending obstetrics clinic at Ohud Hospital, Madina, Saudi Arabia between April 2014 and March 2015. Measurement of serum SHBG levels by Enzyme-linked immunosorbent assay (ELISA) method were done between 24 and 28 weeks of gestation. The best cut-off point of SHBG to diagnose GDM was calculated in receiver operating characteristic curve.
  
  
  
  Compared with the control group, SHBG concentrations were significantly lower in the GDM group; median 23 nmol/L (18-30) vs. 78 nmol/L (65-96), p < 0.001). The cut off value 50 nmol/L of the SHBG had 90% sensitivity and 96% specificity to diagnose GDM.
  
  
  
  Patients with GDM have lower circulating levels of SHBG than normal glucose tolerance pregnant women. Circulating concentrations of SHBG represent a potentially useful new biomarker for prediction of risk of GDM beyond the currently established clinical and demographic risk factors.
authors.affiliation: Clinical Biochemistry and Molecular Medicine Department, Taibahu University, College of Medicine, Madina, Saudi Arabia. Manalhammoda1965@yahoo.com.|Clinical and Chemical Pathology Department, Tanta University, College of Medicine, Tanta, Egypt. Manalhammoda1965@yahoo.com.
authors.forename: Manal Abdalla
authors.initials: MA
authors.lastname: Tawfeek
authors.affiliation: Internal Medicine Department, College of Medicine, Taibahu University, Madina, Saudi Arabia.
authors.forename: Eman Mohamad
authors.initials: EM
authors.lastname: Alfadhli
authors.affiliation: Clinical Biochemistry and Molecular Medicine Department, Taibahu University, College of Medicine, Madina, Saudi Arabia.
authors.forename: Abdulfatah Marawan
authors.initials: AM
authors.lastname: Alayoubi
authors.affiliation: Center for Genetics and Inherited Diseases and Medical Laboratories Technology Department, Taibahu University, Madina, Saudi Arabia.|Biochemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
authors.forename: Hesham Ahmad
authors.initials: HA
authors.lastname: El-Beshbishy
authors.affiliation: Obstetrics & Gynecology Department, Taibahu University, College of Medicine, Madina, Saudi Arabia.
authors.forename: Fawzia Ahmad
authors.initials: FA
authors.lastname: Habib
mesh_terms: D000328:Adult; D000554:Ambulatory Care Facilities / Q000458:organization & administration; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D011247:Pregnancy; D012529:Saudi Arabia; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*
chemical_list: D015415:Biomarkers; D012738:Sex Hormone-Binding Globulin
keywords: Gestational diabetes mellitus; Pregnancy; Saudi Arabia; Sex hormone binding globulin