title: [Are risk factors in prenatal and perinatal period important for develompent of schizophrenia?]
abstract: OBJECTIVE
  Schizophrenia is an important psychical disease of multifactorial origin and not yet clear etiology. In prenatal and perinatal period some potential risk factors for schizophrenia are taken into consideration.
  
  
  METHODS
  Case-control study of 815 subjects, 407 cases and 408 controls was performed in 2013 to 2015.
  
  
  METHODS
  In this study environmental and genetic risk factors were evaluated including potential risk factors of prenatal and perinatal period.
  
  
  RESULTS
  Statistically important difference was found in child-birth done by cesarean section (p = 0.009) and in patients with schizophrenia were 15.7% complications in the course of childbirth (p < 0.001). Hypoxia, passed umbilical cord were the most frequent complications. In prenatal period premature childbirth, injury and psychical complications were the most frequent. On the other hand difference in weight and length of newborns, breast feeding and infection during pregnancy were found not statistically important.
  
  
  CONCLUSIONS
  In this study statistically important diference were found in way of carrying childbirth and in some complications during pregnancy and delivery. Influence of infection during pregnancy and influence of weight and length of newborn were not demonstrated.
authors.forename: P
authors.initials: P
authors.lastname: Ambroz
authors.forename: J
authors.initials: J
authors.lastname: Janoutová
authors.forename: O
authors.initials: O
authors.lastname: Machaczka
authors.forename: M
authors.initials: M
authors.lastname: Kovaľová
authors.forename: A
authors.initials: A
authors.lastname: Pohlídalová
authors.forename: K
authors.initials: K
authors.lastname: Vařechová
authors.forename: O
authors.initials: O
authors.lastname: Košta
authors.forename: H
authors.initials: H
authors.lastname: Tomášková
authors.forename: O
authors.initials: O
authors.lastname: Šerý
authors.forename: L
authors.initials: L
authors.lastname: Hosák
authors.forename: V
authors.initials: V
authors.lastname: Janout
mesh_terms: D000328:Adult; D001724:Birth Weight; D001942:Breast Feeding; D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data*; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000453:epidemiology*; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D047928:Premature Birth / Q000453:epidemiology*; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology*
keywords: childbirth infection.; pregnancy; risk factors; schizophrenia