title: The Kidney in Aging: Physiological Changes and Pathological Implications.
abstract: Aging is associated with progressive decline in renal function along with concurrent morphological changes that ultimately lead to glomerulosclerosis. The mechanisms leading to such changes in the kidney with age as well as the basis of controversies that surround the physiological basis vs pathological nature of aging kidney are the focus of this in-depth review. In addition, the renal functional defects of acid-base homeostasis and electrolyte disturbances in elderly and the physiological basis of such disorders are also discussed.
authors.affiliation: Texas Tech University Health Sciences Center, Lubbock, TX, United States.
authors.forename: H
authors.initials: H
authors.lastname: Sobamowo
authors.affiliation: Texas Tech University Health Sciences Center, Lubbock, TX, United States. Electronic address: sharma.prabhakar@ttuhsc.edu.
authors.forename: S S
authors.initials: SS
authors.lastname: Prabhakar
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000503:physiopathology*; D007677:Kidney Function Tests; D008954:Models, Biological; D015398:Signal Transduction
keywords: Aging; Geriatric nephrology; Kidney failure; Renal physiology