title: A new sucrosephenylpropanoid ester from Polygonum pubescens Blume.
abstract: The present study investigated the chemical constituents of aerial part of Polygonum pubescens Blume. Twenty-two compounds 1-22 were obtained from petroleum ether and ethyl acetate extracts of aerial part of P. pubescens, including a new phenylpropanoide esters 1 and 21 known compounds. The structures were determined on the basis of spectroscopic and chemical methods. Sixteen compounds were assessed for their cytotoxic and anti-inflammatory activities. Several compounds showed effects on different targets.
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha , China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha , China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: b National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi , Oxford , MS , USA.
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhao
authors.affiliation: b National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi , Oxford , MS , USA.
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha , China.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Liu
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha , China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zeng
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha , China.
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Peng
authors.affiliation: c Hunan Provincial Key Laboratory of Diagnostics and Therapeutic Research in Chinese Medicine , Hunan University of Chinese Medicine , Changsha , China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Cai
authors.affiliation: c Hunan Provincial Key Laboratory of Diagnostics and Therapeutic Research in Chinese Medicine , Hunan University of Chinese Medicine , Changsha , China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Peng
authors.affiliation: c Hunan Provincial Key Laboratory of Diagnostics and Therapeutic Research in Chinese Medicine , Hunan University of Chinese Medicine , Changsha , China.
authors.forename: Huiyong
authors.initials: H
authors.lastname: Huang
authors.affiliation: b National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi , Oxford , MS , USA.
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D028502:Polygonum / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D002934:Cinnamates; D016328:NF-kappa B; D010936:Plant Extracts; C087105:vanicoside A
keywords: Polygonum pubescens Blume; anti-inflammatory activity; chemical constituents; cytotoxic activity