title: Vegetable and Fruit Intakes Are Associated with hs-CRP Levels in Pre-Pubertal Girls.
abstract: The influence of diet on inflammation in children remains unclear. We aimed to analyze the influence of diet on high-sensitivity C-reactive protein (hs-CRP) levels in a pre-pubertal population free of other influences that may affect hs-CRP levels. We determined hs-CRP levels in 571 six- to eight-year-old children using an hs-CRP ELISA kit. Information on food and nutrient intake was obtained through a food-frequency questionnaire. Overall dietary quality was assessed using the Healthy Eating Index (HEI). We found that girls in the highest tertile of hs-CRP levels had a higher intake of saturated fatty acid, and lower intakes of fiber and vitamin E and a lower HEI score when compared to those in tertiles 1 and 2. We also observed a significant decrease in fruit and vegetable intakes by hs-CRP tertile. Factor analysis showed that a dietary pattern that was loaded most strongly with vegetable, fruit, fiber and vitamin A and E intakes correlated negatively (-0.132,p< 0.05) with hs-CRP. No such association was found in boys. In conclusion, our data show that girls with a poorer quality diet show higher hs-CRP levels already at a pre-pubertal age.
authors.affiliation: Lipid Laboratory, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain. pilar.nsanchez@quironsalud.es.
authors.forename: Pilar
authors.initials: P
authors.lastname: Navarro
authors.affiliation: Lipid Laboratory, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain. olaya.dios@quironsalud.es.
authors.forename: Olaya
authors.initials: O
authors.lastname: de Dios
authors.affiliation: Lipid Laboratory, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain. ashamaya08@gmail.com.
authors.forename: Asha
authors.initials: A
authors.lastname: Jois
authors.affiliation: Lipid Laboratory, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain. TGavela@fjd.es.|Department of Pediatrics, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain. TGavela@fjd.es.
authors.forename: Teresa
authors.initials: T
authors.lastname: Gavela-Pérez
authors.affiliation: Department of Preventive Medicine and Public Health and INCLIVA-Clinical Hospital, University of Valencia, 46010 Valencia, Spain. lydia.gorgojo@gmail.com.
authors.forename: Lydia
authors.initials: L
authors.lastname: Gorgojo
authors.affiliation: Department of Preventive Medicine and Public Health and INCLIVA-Clinical Hospital, University of Valencia, 46010 Valencia, Spain. dr.martinmoreno@gmail.com.
authors.forename: José M
authors.initials: JM
authors.lastname: Martín-Moreno
authors.affiliation: Lipid Laboratory, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain. LSoriano@fjd.es.|Department of Pediatrics, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain. LSoriano@fjd.es.
authors.forename: Leandro
authors.initials: L
authors.lastname: Soriano-Guillen
authors.affiliation: Lipid Laboratory, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain. cgarces@fjd.es.
authors.forename: Carmen
authors.initials: C
authors.lastname: Garcés
mesh_terms: D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D003430:Cross-Sectional Studies; D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage; D005227:Fatty Acids / Q000008:administration & dosage; D005260:Female; D063427:Food Quality; D005638:Fruit; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D011627:Puberty; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D014675:Vegetables; D014801:Vitamin A / Q000008:administration & dosage; D014810:Vitamin E / Q000008:administration & dosage
chemical_list: D004043:Dietary Fiber; D005227:Fatty Acids; D014801:Vitamin A; D014810:Vitamin E; D002097:C-Reactive Protein
keywords: antioxidants; fibre intake; fruit intake; hs-CRP levels; pre-pubertal children; vegetable intake