title: Predictive value of preoperative neutrophil-to-lymphocyte ratio on the prognosis of germ cell testicular tumors.
abstract: OBJECTIVE
  We investigated the prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR) on germ cell testicular tumors (GCT).
  
  
  METHODS
  The data of 53 patients who underwent inguinal orchiectomy were analyzed retrospectively. NLR was calculated from the preoperative complete blood cell counts. Receiver operating characteristic (ROC) analysis was performed to find the threshold values for NLR. Correlations between cancer-specific survival (CSS) and progression-free survival (PFS) and NLR were evaluated.
  
  
  RESULTS
  The mean follow-up time was 23.55±18.06 months. The mean level of NLR was 3.08±1.81. Optimal threshold values of NLR was calculated as 3.55 for PFS (area under curve, AUC: 0.55) and 3.0 for CSS (AUC: 0.66). For patients with a NLR of <3.55 and NLR of ≥3.55, mean times-to-progression were 55.71 months (95% CI, 51.27-60.14) and 51.95 months (95% CI, 38.02-65.87, p=0.152), respectively. As well as, for patients with a NLR of <3.0 and NLR of ≥3.0, mean times-to-cancer specific death were 54.72 months (95% CI, 49.05-60.38) and 49.43 months (95% CI, 37.64-61.22, p=0.119), respectively.
  
  
  CONCLUSIONS
  Preoperative NLR is not a useful tool to predict the prognosis of patients with GCT.
authors.affiliation: Clinic of Urology, Bozyaka Training and Research Hospital, İzmir, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Bolat
authors.affiliation: Clinic of Urology, Bozyaka Training and Research Hospital, İzmir, Turkey.
authors.forename: Özgü
authors.initials: Ö
authors.lastname: Aydoğdu
authors.affiliation: Clinic of Urology, Bozyaka Training and Research Hospital, İzmir, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Polat
authors.affiliation: Clinic of Urology, Bozyaka Training and Research Hospital, İzmir, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Yarımoğlu
authors.affiliation: Clinic of Urology, Bozyaka Training and Research Hospital, İzmir, Turkey.
authors.forename: İbrahim Halil
authors.initials: İH
authors.lastname: Bozkurt
authors.affiliation: Clinic of Urology, Bozyaka Training and Research Hospital, İzmir, Turkey.
authors.forename: Tarık
authors.initials: T
authors.lastname: Yonguç
authors.affiliation: Clinic of Urology, Bozyaka Training and Research Hospital, İzmir, Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Şen
keywords: Inflammation; neutrophil-lymphocyte ratio; prognosis; survival; testicular cancer