title: Bridging the Gaps: iPSC-Based Models from CHIP to MDS to AML.
abstract: Myeloid malignancies exist on a spectrum from asymptomatic clonal hematopoiesis to overt leukemia and exhibit substantial clonal heterogeneity. Both aspects are challenging to capture in experimental models. In two landmark studies in this issue of Cell Stem Cell, Kotini et al. (2017) and Chao et al. (2017) establish iPSC-based experimental platforms that recapitulate disease stages and clonal architecture.
authors.affiliation: The Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: berntk@email.chop.edu.
authors.forename: Kathrin M
authors.initials: KM
authors.lastname: Bernt
mesh_terms: D002999:Clone Cells; D006410:Hematopoiesis; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D015470:Leukemia, Myeloid, Acute; D009190:Myelodysplastic Syndromes