title: Body composition analysis and adipocytokine concentrations in haemodialysis patients: abdominal fat gain as an additional cardiovascular risk factor.
abstract: BACKGROUND
  Abdominal fat and its increment over time in particular has become a cardiovascular risk factor in uraemic patients.
  
  
  OBJECTIVE
  To analyse changes in abdominal fat in haemodialysis patients over one year and study their possible correlation with the variation in adipocytokine serum levels. As a secondary objective, we tried to validate the data obtained by bioelectrical impedance analysis (BIA) with data obtained by dual X-ray absorptiometry (DXA).
  
  
  METHODS
  A prospective one-year study was performed in 18 patients on haemodialysis (HD). In each patient, body composition by BIA and DXA was estimated at baseline and after one year. Several adipocytokine and biochemical parameters were determined.
  
  
  RESULTS
  A significant increase in phase angle [4.8° (4.1-5.6) vs. 5.2° (4.4-5.8), P<.05], BIA intracellular water [48.3% (43.1-52.3) vs. 50.3% (45.7-53.4), P<.05] and the ratio between the percentage of android/gynecoid (A/G) distribution of fat measured by DXA [1.00 (0.80-1.26) vs. 1.02 (0.91-1.30), P<.05] was observed. A statistically significant relationship between leptin and adiponectin concentrations and the percentage of fat mass measured by BIA, as well as the abdominal fat percentage estimated by DXA, was found (P<.01).
  
  
  CONCLUSIONS
  HD patients exhibit a gain in fat mass over time, especially in the abdomen, evidenced by an increased A/G ratio. These findings might explain the increased cardiovascular risk in these patients.
authors.affiliation: Servicios de Nefrología, Hospital Universitario La Paz, IdiPAZ, FRIAT-IRSIN, REDinREN, Madrid, España. Electronic address: mariaelena.gonzalez.garcia@salud.madrid.org.
authors.forename: Elena
authors.initials: E
authors.lastname: González
authors.affiliation: Servicio de Endocrinología, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Díez
authors.affiliation: Servicios de Nefrología, Hospital Universitario La Paz, IdiPAZ, FRIAT-IRSIN, REDinREN, Madrid, España.
authors.forename: Almudena
authors.initials: A
authors.lastname: Pérez Torres
authors.affiliation: Servicios de Nefrología, Hospital Universitario La Paz, IdiPAZ, FRIAT-IRSIN, REDinREN, Madrid, España.
authors.forename: María Auxiliadora
authors.initials: MA
authors.lastname: Bajo
authors.affiliation: Servicios de Nefrología, Hospital Universitario La Paz, IdiPAZ, FRIAT-IRSIN, REDinREN, Madrid, España.
authors.forename: Gloria
authors.initials: G
authors.lastname: Del Peso
authors.affiliation: Servicios de Nefrología, Hospital Universitario La Paz, IdiPAZ, FRIAT-IRSIN, REDinREN, Madrid, España.
authors.forename: Rafael
authors.initials: R
authors.lastname: Sánchez-Villanueva
authors.affiliation: Servicio de Bioquímica, Hospital Universitario La Paz, IdiPAZ, FRIAT-IRSIN, REDinREN, Madrid, España.
authors.forename: Cristina
authors.initials: C
authors.lastname: Grande
authors.affiliation: Servicio de Bioquímica, Hospital Universitario La Paz, IdiPAZ, FRIAT-IRSIN, REDinREN, Madrid, España.
authors.forename: Olaia
authors.initials: O
authors.lastname: Rodríguez
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario La Paz, IdiPAZ, FRIAT-IRSIN, REDinREN, Madrid, España.
authors.forename: Mónica
authors.initials: M
authors.lastname: Coronado
authors.affiliation: Servicio de Nutrición, Hospital Universitario La Paz, IdiPAZ, FRIAT-IRSIN, REDinREN, Madrid, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Gómez Candela
authors.affiliation: Servicio de Bioestadística, Hospital Universitario La Paz, IdiPAZ, FRIAT-IRSIN, REDinREN, Madrid, España.
authors.forename: Mariana
authors.initials: M
authors.lastname: Díaz-Almirón
authors.affiliation: Servicio de Endocrinología, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: Pedro
authors.initials: P
authors.lastname: Iglesias
authors.affiliation: Servicios de Nefrología, Hospital Universitario La Paz, IdiPAZ, FRIAT-IRSIN, REDinREN, Madrid, España.
authors.forename: Rafael
authors.initials: R
authors.lastname: Selgas
mesh_terms: D050153:Abdominal Fat; D054392:Adipokines / Q000097:blood*; D000368:Aged; D001823:Body Composition; D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis; D012307:Risk Factors
chemical_list: D054392:Adipokines
keywords: Absorciometría dual de rayos X (DXA); Adiponectin; Adiponectina; Bioimpedancia eléctrica (BIA); Dual X-ray absorptiometry (DXA); Electrical bioimpedance (BIA); FGF-21; Haemodialysis; Hemodiálisis; Leptin; Leptina