title: Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria.
abstract: Animal models are essential to studies of infectious diseases. The use of mice to test bacterial infection has been extensively reported. However, methods applied to clinical isolates, particularly for carbapenem-resistant bacteria, must be tailored according to the infection models and bacteria used. In this study, we infected 6-week-old female BALB/c mice intraperitoneally with different strains of resistant bacteria plus 3% hog gastric mucin. This method was found to be efficient and readily applicable for investigation of carbapenem-resisant Gram-negative pathogens (e.g., Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii) detected in Korea.
authors.affiliation: Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jung Yeon
authors.identifier: http://orcid.org/0000-0002-9815-7123
authors.initials: JY
authors.lastname: Park
authors.affiliation: Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Chulmin
authors.initials: C
authors.lastname: Park
authors.affiliation: Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Hye Sun
authors.initials: HS
authors.lastname: Chun
authors.affiliation: Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Byun
authors.affiliation: Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.|Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Sung Yeon
authors.initials: SY
authors.lastname: Cho
authors.affiliation: Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.|Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. symonlee@catholic.ac.kr.
authors.forename: Dong Gun
authors.identifier: http://orcid.org/0000-0003-4655-0641
authors.initials: DG
authors.lastname: Lee
keywords: Drug resistance, Multidrug resistance; Gram-negative bacteria; Laboratory animal models; Peritonitis