title: The link between obesity and migraine in childhood: a systematic review.
abstract: Obesity and headache are two highly prevalent diseases both in adults and children and they are associated with a strong personal and social impact. Many studies suggest that obesity is comorbid with headache in general, and migraine in particular and obesity seems to be a risk factor for migraine progression and for migraine frequency both in adults and in children. Research shows that there are multiple areas of overlap between migraine pathophysiology and the central and peripheral pathways regulating feeding: inflammatory mediators such as the calcitonin gene-related protein (CGRP), neurotransmitters such as serotonin, peptides such as orexin and adipocytokines such as adiponectin (ADP) and leptin could explain the common pathogenesis. In this paper we discussed the association between obesity and migraine through the analysis of the most recent studies in children and we reviewed data from literature in order to assess the association between obesity and headache and to clarify the possible common pathogenic mechanisms.
authors.affiliation: Department of Pediatrics, University of L'Aquila, Via Vetoio 1, Coppito, 67100, L'Aquila, Italy. giovanni.farello@cc.univaq.it.
authors.forename: G
authors.identifier: http://orcid.org/0000-0002-3230-7555
authors.initials: G
authors.lastname: Farello
authors.affiliation: Department of Pediatrics, Catholic University, A. Gemelli Hospital, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Ferrara
authors.affiliation: Department of Pediatrics, University of L'Aquila, Via Vetoio 1, Coppito, 67100, L'Aquila, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Antenucci
authors.affiliation: Department of Pediatrics, University of L'Aquila, Via Vetoio 1, Coppito, 67100, L'Aquila, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Basti
authors.affiliation: Department of Pediatrics, University of L'Aquila, Via Vetoio 1, Coppito, 67100, L'Aquila, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Verrotti
mesh_terms: D002648:Child; D015897:Comorbidity / Q000639:trends; D014943:Global Health; D006801:Humans; D008881:Migraine Disorders / Q000453:epidemiology*; D063766:Pediatric Obesity / Q000453:epidemiology*; D018570:Risk Assessment; D012307:Risk Factors
keywords: Children; Headache; Migraine; Obesity; Proinflammatory cytokines