title: Bilateral Breast Cancer After Prophylactic Bilateral Pulmonary Irradiation.
abstract: The purpose of this article is to report a new case of a probably radio-induced bilateral breast cancer occurred after prophylactic bilateral pulmonary irradiation in the treatment of osteosarcoma. A 42-year-old woman, treated at the age of 12 years for osteosarcoma at the right lower limb with chemotherapy (methotrexate, adriamycin and cisplatin) followed by non-conservative surgery and adjuvant radiotherapy. Eighteen years after, she developed her first breast cancer, and five years later, her second contralateral breast cancer. The patient was treated for her two non-metastatic cancers and is currently in complete remission. This publication adds to several previous publications the very probable effect of ionizing radiation in the occurrence of secondary cancers.
authors.affiliation: Department of Radiation Oncology, Hospital of Farhat Hached, Susah, Tunisia.|Institut de Cancérologie Lucien-Neuwirth, Department of Radiation Oncology, 108 bis, Avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Hamrouni A
authors.initials: HA
authors.lastname: El Meddeb
authors.affiliation: Department of Radiation Oncology, Hospital of Farhat Hached, Susah, Tunisia.
authors.forename: Jebsi M
authors.initials: JM
authors.lastname: Chehata
authors.affiliation: Department of Radiation Oncology, Hospital of Farhat Hached, Susah, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Kanoun
authors.affiliation: Department of Radiation Oncology, Hospital of Farhat Hached, Susah, Tunisia.
authors.forename: C
authors.initials: C
authors.lastname: Rancoule
authors.affiliation: Department of Radiation Oncology, Hospital of Farhat Hached, Susah, Tunisia.
authors.forename: J B
authors.initials: JB
authors.lastname: Guy
authors.affiliation: Department of Radiation Oncology, Hospital of Farhat Hached, Susah, Tunisia.
authors.forename: N
authors.initials: N
authors.lastname: Magne
authors.affiliation: Department of Radiation Oncology, Hospital of Farhat Hached, Susah, Tunisia.
authors.forename: N
authors.initials: N
authors.lastname: Bouaouina
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D001943:Breast Neoplasms / Q000209:etiology*; D002945:Cisplatin; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D012516:Osteosarcoma / Q000532:radiotherapy*; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects*
chemical_list: D002945:Cisplatin