title: Associations of Vigorous-Intensity Physical Activity with Biomarkers in Youth.
abstract: Physical activity (PA) conveys known cardiometabolic benefits to youth, but the contribution of vigorous-intensity PA (VPA) to these benefits is unknown. Therefore, we sought to determine (a) the associations between VPA and cardiometabolic biomarkers independent of moderate-intensity PA (MPA) and time sedentary and (b) the accelerometer cut point that best represents the threshold for health-promoting VPA in youth.
  
  
  
  Data from the International Children's Accelerometry Database (ICAD) were analyzed in 2015. The relationship between cardiometabolic biomarkers and four categories of VPA estimated via three sets of cut points were examined using isotemporal substitution quantile regression modeling at the 10th, 25th, 50th, 75th, and 90th percentile of the distribution of each biomarker, separately. Age, sex, accelerometer wear time, sedentary time, and MPA were controlled for while allowing substitution for light-intensity PA. Data from 11,588 youth (4-18 yr) from 11 ICAD studies (collected 1998-2009) were analyzed.
  
  
  
  Only 32 of 360 significant associations were observed. Significant, negative relationships were observed for VPA with waist circumference and insulin. Replacing light-intensity PA with VPA (corresponding to at the 25th to 90th percentiles of VPA) was associated with 0.67 (-1.33 to -0.01; P = 0.048) to 7.30 cm (-11.01 to -3.58; P < 0.001) lower waist circumference using Evenson and ICAD cut points (i.e., higher counts per minute). VPA levels were associated with 12.60 (-21.28 to -3.92; P = 0.004) to 27.03 pmol·L (-45.03 to -9.03; P = 0.003) lower insulin levels at the 75th to 90th percentiles using Evenson and ICAD cut points when substituted for light PA.
  
  
  
  Substituting light PA with VPA was inversely associated with waist circumference and insulin. However, VPA was inconsistently related to the remaining biomarkers after controlling for time sedentary and MPA.
authors.affiliation: 1Department of Family and Community Medicine, Wake Forest School of Medicine, Winston-Salem, NC; 2Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC; 3Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC; 4Department of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, DENMARK; 5Department of Sport Medicine, Norwegian School of Sport Science, Oslo, NORWAY; 6Federal University of Pelotas, Pelotas, BRAZIL; 7School of Social and Community Medicine, University of Bristol, Bristol, UNITED KINGDOM; 8Epidemiology, Biostatistics and Public Health Institute, University of Zürich, Zürich, SWITZERLAND; 9Physical Activity for Health Group, School of Psychological Sciences and Health, University of Strathclyde, Glasgow, UNITED KINGDOM; and 10Exercise and Health Laboratory, CIPER, Faculty of Human Kinetics, University of Lisbon, Cruz-Quebrada, PORTUGAL.
authors.forename: Justin B
authors.initials: JB
authors.lastname: Moore
authors.forename: Michael W
authors.initials: MW
authors.lastname: Beets
authors.forename: Keith
authors.initials: K
authors.lastname: Brazendale
authors.forename: Steven N
authors.initials: SN
authors.lastname: Blair
authors.forename: Russell R
authors.initials: RR
authors.lastname: Pate
authors.forename: Lars B
authors.initials: LB
authors.lastname: Andersen
authors.forename: Sigmund A
authors.initials: SA
authors.lastname: Anderssen
authors.forename: Anders
authors.initials: A
authors.lastname: Grøntved
authors.forename: Pedro C
authors.initials: PC
authors.lastname: Hallal
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kordas
authors.forename: Susi
authors.initials: S
authors.lastname: Kriemler
authors.forename: John J
authors.initials: JJ
authors.lastname: Reilly
authors.forename: Luis B
authors.initials: LB
authors.lastname: Sardinha
mesh_terms: D061725:Accelerometry; D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D001794:Blood Pressure / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D057185:Sedentary Behavior; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol