title: First assessment of simultaneous dual isotope (123I/99mTc) cardiac SPECT on two different CZT cameras: A phantom study.
abstract: We studied the impact of simultaneous dual-isotope acquisition on123I/99mTc mismatch assessment using two CZT cameras (DNM 530c, GE Healthcare and DSPECT, Biosensors International).
  
  
  
  We used an anthropomorphic torso phantom (respectively filled with a solution of123I alone,99mTc alone, and a mixture of123I and99mTc) and its cardiac insert with two defects mimicking two matched and mismatched defects. Mismatch extent and reconstructed image contrast were evaluated.
  
  
  
  The acquisition mode (single vs dual) significantly impacted (i)99mTc (but not123I) reconstructed segmental activities using both camera (P < .001), and (ii) image contrast (using123I and DNM 530c, P < .0001; and using both123I and99mTc with DSPECT, P < .0001). However, the defect and mismatch size were not impacted by the type of acquisition. With both DNM 530c and DSPECT, Lin's concordance correlation coefficient and Bland-Altman analysis demonstrated an almost perfect concordance and agreement between single- and simultaneous dual-isotope segmental activity (123I and99mTc).
  
  
  
  This study found no impact of the acquisition mode (single vs dual) or the type of camera (DSPECT vs DNM 530c) on123I and99mTc defect size and mismatch, providing a new step toward simultaneous dual-isotope acquisition for combined innervation and perfusion assessment.
authors.affiliation: Department of Nuclear Medicine, UF 5881, Groupement des Hôpitaux de l'Institut Catholique de Lille, Lomme, France. ta.blaire@gmail.com.|Normandie Univ, UNICAEN, Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, FHU REMOD-VHF, 14000, Caen, France. ta.blaire@gmail.com.|Department of Nuclear Medicine, IRIS, Hôpital Privé Le Bois, Lille, France. ta.blaire@gmail.com.
authors.forename: Tanguy
authors.initials: T
authors.lastname: Blaire
authors.affiliation: Department of Nuclear Medicine, UF 5881, Groupement des Hôpitaux de l'Institut Catholique de Lille, Lomme, France.|Normandie Univ, UNICAEN, Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, FHU REMOD-VHF, 14000, Caen, France.|Department of Nuclear Medicine, IRIS, Hôpital Privé Le Bois, Lille, France.
authors.forename: Alban
authors.initials: A
authors.lastname: Bailliez
authors.affiliation: Department of Nuclear Medicine, CHU de Montpellier, Montpellier, France.
authors.forename: Fayçal
authors.initials: F
authors.lastname: Ben Bouallegue
authors.affiliation: Department of Nuclear Medicine, CHU Cote de Nacre, Caen, France.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Bellevre
authors.affiliation: Normandie Univ, UNICAEN, Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, FHU REMOD-VHF, 14000, Caen, France.|Department of Nuclear Medicine, CHU Cote de Nacre, Caen, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Agostini
authors.affiliation: Normandie Univ, UNICAEN, Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, FHU REMOD-VHF, 14000, Caen, France.|Department of Nuclear Medicine, CHU Cote de Nacre, Caen, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Manrique
mesh_terms: D002104:Cadmium; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007457:Iodine Radioisotopes; D019047:Phantoms, Imaging; D011849:Radioactive Tracers; D013667:Technetium; D013691:Tellurium; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods*; D015032:Zinc
chemical_list: C474490:CdZnTe; D007457:Iodine Radioisotopes; D011849:Radioactive Tracers; D002104:Cadmium; D013667:Technetium; C000614958:Iodine-123; D015032:Zinc; D013691:Tellurium
keywords: CZT; DNM 530c; DSPECT; dual isotope; mIBG; mismatch