title: Effects of Alpha Lipoic Acid on Multiple Cytokines and Biomarkers and Recurrence of Atrial Fibrillation Within 1 Year of Catheter Ablation.
abstract: Catheter ablation (CA) is a procedure commonly used to restore sinus rhythm in patients with atrial fibrillation (AF). However, AF recurrence after CA remains a relevant clinical issue. We tested the effects of an oral antioxidant treatment (alpha lipoic acid [ALA]) on AF recurrence post-CA. Patients with paroxysmal AF have been enrolled in a randomized, prospective, double-blind, controlled placebo trial. After CA, patients have been randomly assigned to receive ALA oral supplementation (ALA group) or placebo (control group) and evaluated at baseline and after a 12-month follow-up: 73 patients completed the 12-month follow-up (ALA: 33 and control: 40). No significant difference has been detected between the 2 groups at baseline. Strikingly, 1 year after CA, ALA therapy significantly reduced serum markers of inflammation. However, there was no significant difference in AF recurrence events at follow-up comparing ALA with placebo group. Multivariate analysis revealed that the only independent prognostic risk factor for AF recurrence after CA is age. In conclusion, ALA therapy reduces serum levels of common markers of inflammation in ablated patients. Nevertheless, ALA does not prevent AF recurrence after an ablative treatment.
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Arrhythmias and Electrophysiology Department, John Paul II Research Foundation, Campobasso, Italy.
authors.forename: Celestino
authors.initials: C
authors.lastname: Sardu
authors.affiliation: Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy; New York Presbyterian Hospital, Columbia University Medical Center, New York, New York. Electronic address: gsantulli001@gmail.com.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Santulli
authors.affiliation: Arrhythmias and Electrophysiology Department, John Paul II Research Foundation, Campobasso, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Santamaria
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.
authors.forename: Michelangela
authors.initials: M
authors.lastname: Barbieri
authors.affiliation: Arrhythmias and Electrophysiology Department, John Paul II Research Foundation, Campobasso, Italy.
authors.forename: Cosimo
authors.initials: C
authors.lastname: Sacra
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Paolisso
authors.affiliation: Arrhythmias and Electrophysiology Department, John Paul II Research Foundation, Campobasso, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: D'Amico
authors.affiliation: Arrhythmias and Electrophysiology Department, John Paul II Research Foundation, Campobasso, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Testa
authors.affiliation: Arrhythmias and Electrophysiology Department, John Paul II Research Foundation, Campobasso, Italy.
authors.forename: Igor
authors.initials: I
authors.lastname: Caporaso
authors.affiliation: Arrhythmias and Electrophysiology Department, John Paul II Research Foundation, Campobasso, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolisso
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Marfella
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Rizzo
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control* / Q000601:surgery; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D017115:Catheter Ablation; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D016207:Cytokines / Q000276:immunology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D016209:Interleukin-8 / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D030421:Peroxynitrous Acid / Q000378:metabolism; D011182:Postoperative Care; D012008:Recurrence; D008063:Thioctic Acid / Q000627:therapeutic use*; D016896:Treatment Outcome; D014280:Triglycerides / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D014443:Tyrosine / Q000031:analogs & derivatives / Q000276:immunology
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; C508606:CXCL8 protein, human; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D016207:Cytokines; C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; D010446:Peptide Fragments; C439524:TNF protein, human; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D016753:Interleukin-10; D030421:Peroxynitrous Acid; C002744:3-nitrotyrosine; D014443:Tyrosine; D008063:Thioctic Acid; D002097:C-Reactive Protein