title: Case report of three consecutive lues maligna infections in an HIV-infected patient.
abstract: Lues maligna is a rare presentation of an infection with Treponema pallidum. Here we report three lues maligna infections with severe dermatological manifestations in a single HIV-1 infected individual. Despite the start of highly active antiretroviral therapy and a substantial increase in CD4 cell count after the first episode, he developed consecutive episodes. We assume a specific immunological predisposition to react to T. pallidum in this patient.
authors.affiliation: Medizinische Klinik und Poliklinik IV, Section Infectious Diseases, Klinikum der Universität München, Munich, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Sammet
authors.affiliation: Medizinische Klinik und Poliklinik IV, Section Infectious Diseases, Klinikum der Universität München, Munich, Germany.
authors.forename: Rika
authors.initials: R
authors.lastname: Draenert
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D012867:Skin / Q000382:microbiology / Q000473:pathology; D013591:Syphilis, Cutaneous / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D014210:Treponema pallidum / Q000302:isolation & purification*
keywords: CD4 cell count; HIV-1; Lues maligna; Treponema pallidum; reinfection; skin manifestation