title: VEGF-related polymorphisms identified by GWAS and risk for major depression.
abstract: Depression is a common, severe, disabling mental disease that affects millions of people of all ages worldwide. Various studies have shown that neurotrophic/growth factors have a key role in depression and, more specifically, vascular endothelial growth factor (VEGF) is implicated in the pathogenesis of depression. The purpose of this study was to investigate the potential links between four VEGF-related single-nucleotide polymorphisms (SNPs), previously identified through a genome-wide association study (GWAS) and depression. The direct effects and epistatic interactions of the four VEGF-related SNPs (rs10738760, rs6921438, rs6993770 and rs4416670) on depression were investigated through a case-control study including 437 individuals diagnosed with depression and 477 healthy volunteers as controls. Gender, age and body mass index influence was additionally analyzed. The SNP rs4416670 was associated with increased risk for depression (OR: 1.60, P: 0.010). This result demonstrates the existence of relationships between VEGF genetic determinants and depression. This novel association reveals new molecular mechanisms suggesting the potential role of VEGF in depression development that could help to promote a personalized prediction for this severe common disease.
authors.affiliation: UMR INSERM U1122, Interactions Gène-Environnement en Physiopathologie Cardio-Vasculair, Université de Lorraine, Nancy, France.
authors.forename: T
authors.initials: T
authors.lastname: Xie
authors.affiliation: UMR INSERM U1122, Interactions Gène-Environnement en Physiopathologie Cardio-Vasculair, Université de Lorraine, Nancy, France.
authors.forename: M G
authors.initials: MG
authors.lastname: Stathopoulou
authors.affiliation: CICAB Clinical Research Centre, Extremadura University Hospital, Badajoz, Spain.
authors.forename: F
authors.initials: F
authors.lastname: de Andrés
authors.affiliation: UMR INSERM U1122, Interactions Gène-Environnement en Physiopathologie Cardio-Vasculair, Université de Lorraine, Nancy, France.
authors.forename: G
authors.initials: G
authors.lastname: Siest
authors.affiliation: Randox Laboratories, Crumlin, UK.
authors.forename: H
authors.initials: H
authors.lastname: Murray
authors.affiliation: Clinica de Rehabilitación de Salud Mental, Servicio Navarro de Salud, Pamplona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Martin
authors.affiliation: Centro de Atención Primaria Ciudad Jardín, Servicio Extremeño de Salud, Badajoz, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Cobaleda
authors.affiliation: CICAB Clinical Research Centre, Extremadura University Hospital, Badajoz, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Delgado
authors.affiliation: Randox Laboratories, Crumlin, UK.
authors.forename: J
authors.initials: J
authors.lastname: Lamont
authors.affiliation: CICAB Clinical Research Centre, Extremadura University Hospital, Badajoz, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Peñas-LIedó
authors.affiliation: CICAB Clinical Research Centre, Extremadura University Hospital, Badajoz, Spain.|CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: LLerena
authors.affiliation: UMR INSERM U1122, Interactions Gène-Environnement en Physiopathologie Cardio-Vasculair, Université de Lorraine, Nancy, France.
authors.forename: S
authors.initials: S
authors.lastname: Visvikis-Siest
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A