title: Coexisting lateral tibiofemoral osteoarthritis is associated with worse knee pain in patients with mild medial osteoarthritis.
abstract: To examine the clinical impact of coexisting lateral osteoarthritis (OA) in knees with mild medial OA.
  
  
  
  In patients with Kellgren/Lawrence (K/L) grade 2 OA in the medial compartment (n = 100; age: 56-89 years; 80.0% female), anteroposterior knee radiography was used to assess the presence of lateral OA, using grading systems from the Osteoarthritis Research Society International (OARSI) atlas and the K/L classification. The Japanese Knee Osteoarthritis Measure (JKOM), knee range of motion (ROM), and performance-based functional measures (10 m walk, timed up and go and five repetition chair stand maneuvers) were evaluated. The outcomes were compared between patients with and without lateral OA using an analysis of covariance (ANCOVA) or nonparametric rank ANCOVA. Furthermore, ordinal logistic regression analysis was performed, with responses on individual JKOM pain questionnaires as the outcomes and lateral OA as the predictor.
  
  
  
  Knees with coexisting lateral OA had a significantly worse score of JKOM pain question compared with those without, after adjusting for covariates. The presence of lateral OA was significantly associated with knee pain while ascending/descending stairs and standing. These results were consistent between different definitions of the K/L and OARSI grading systems. The knee ROM and performance-based functional measures were not significantly different between patients with and without lateral OA.
  
  
  
  Knees with concomitant lateral and mild medial OA may be more symptomatic compared to those without lateral OA. These findings might help to define a clinically distinct subgroup based on a simple radiographic finding in mild knee OA.
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Japan Society for the Promotion of Science, Tokyo, Japan. Electronic address: iijimahirotaka@gmail.com.
authors.forename: H
authors.initials: H
authors.lastname: Iijima
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: aoyama.tomoki.4e@kyoto-u.ac.jp.
authors.forename: T
authors.initials: T
authors.lastname: Aoyama
authors.affiliation: Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: nkohei@kuhp.kyoto-u.ac.jp.
authors.forename: K
authors.initials: K
authors.lastname: Nishitani
authors.affiliation: Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: hiromu@kuhp.kyoto-u.ac.jp.
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: nafukutani@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Fukutani
authors.affiliation: Rehabilitation Center, Fujioka General Hospital, Gunma, Japan. Electronic address: isho.tak@gmail.com.
authors.forename: T
authors.initials: T
authors.lastname: Isho
authors.affiliation: Nozomi Orthopedic Clinic, Hiroshima, Japan. Electronic address: EishiKaneda@nozomi-clinic.jp.
authors.forename: E
authors.initials: E
authors.lastname: Kaneda
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: kuroki.hiroshi.6s@kyoto-u.ac.jp.
authors.forename: H
authors.initials: H
authors.lastname: Kuroki
authors.affiliation: Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: smat522@kuhp.kyoto-u.ac.jp.
authors.forename: S
authors.initials: S
authors.lastname: Matsuda
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D018771:Arthralgia / Q000209:etiology* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D005269:Femur; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011859:Radiography; D016059:Range of Motion, Articular / Q000502:physiology; D013977:Tibia
keywords: Knee pain; Lateral tibiofemoral osteoarthritis; Radiography