title: Anti-cyclic citrullinated peptide antibodies are not frequently observed in children with type 1 diabetes mellitus: a single-center study.
abstract: Type 1 diabetes mellitus (DM) and rheumatoid arthritis (RA) have been reported to occur concurrently in some cases. This study aimed to evaluate the presence of anti-cyclic citrullinated peptide (CCP) antibodies, which have been reported to have diagnostic value for RA, in children with type 1 DM. The study included 90 children with type 1 DM (Group 1) and 76 control cases (Group 2). The rates of reported family histories of RA and rheumatoid factor positivity did not differ between groups. In group 1, one case (1.1%) was positive for anti-CCP antibodies, whereas none of the controls were positive. The anti-CCP positive patient had no relevant joint complaints. Anti-CCP antibodies were rarely found in cases of pediatric type 1 DM. Thus, relevant screening in the follow-up of pediatric patients does not appear to be rational in the absence of any signs or symptoms of arthritis. The single case exhibiting a high anti-CCP level needs to be followed up for RA, although this positive result might be nonspecific and transient.
authors.affiliation: Divisions of Pediatric Endocrinology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Melek
authors.initials: M
authors.lastname: Yıldız
authors.affiliation: Divisions of Biochemistry, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: İşleten
authors.affiliation: Divisions of Pediatric Endocrinology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Korcan
authors.initials: K
authors.lastname: Demir
authors.affiliation: Divisions of Biochemistry, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Çelik
authors.affiliation: Divisions of Pediatric Endocrinology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Hüseyin Anıl
authors.initials: HA
authors.lastname: Korkmaz
authors.affiliation: Divisions of Biochemistry, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Birsen
authors.initials: B
authors.lastname: Tuğlu
authors.affiliation: Divisions of Pediatric Endocrinology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Nalbantoğlu
authors.affiliation: Divisions of Pediatric Endocrinology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Behzat
authors.initials: B
authors.lastname: Özkan
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D010456:Peptides, Cyclic / Q000276:immunology*; D012217:Rheumatoid Factor / Q000097:blood
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor
keywords: anti-cyclic citrullinated peptide antibodies; rheumatoid arthritis; type 1 diabetes mellitus