title: Cyclodextrin-based miniaturized solid phase extraction for biopesticides analysis in water and vegetable juices samples analyzed by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
abstract: A cyclodextrin-based miniaturized solid-phase extraction was developed to extract biopesticides from water and vegetable juices. The analytes were detected by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. In the solid-phase extraction (SPE) procedure, the liquid sample solution is passed through a packed column filled with 40mg of HP-β-CD, and then the target analytes are absorbed and finally eluted with methanol-acetic acid (90:10, v/v) into a collection tube. The limits of quantification ranged from 3.73 to 16.51ng/mL for a water matrix, from 2.62 to 13.23ng/mL for an orange juice matrix and from 1.76 to 10.35ng/mL for a tomato juice matrix, respectively. The average recovery values were in the range of 88.3-95.9% for the spiked samples. The established methodology was successfully applied to analyze sanguinarine, berberine, rotenone and osthole in water, orange juice and tomato juice.
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
authors.forename: Li-Qing
authors.initials: LQ
authors.lastname: Peng
authors.affiliation: Hangzhou Red Cross Hospital, Department of Traditional Chinese Medicine, Hangzhou 310003, China.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Ye
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China. Electronic address: caojun91@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address: tcmcyx@126.com.
authors.forename: Yan-Xu
authors.initials: YX
authors.lastname: Chang
authors.affiliation: Institute of Matetia Medica, Zhejiang Acdemy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, United States.
authors.forename: Mingrui
authors.initials: M
authors.lastname: An
authors.affiliation: Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, United States.
authors.forename: Zhijing
authors.initials: Z
authors.lastname: Tan
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Xu
mesh_terms: D061046:Biological Control Agents / Q000032:analysis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003505:Cyclodextrins / Q000378:metabolism*; D000067030:Fruit and Vegetable Juices / Q000382:microbiology*; D013058:Mass Spectrometry / Q000379:methods*; D052616:Solid Phase Extraction / Q000379:methods*; D014871:Water Microbiology
chemical_list: D061046:Biological Control Agents; D003505:Cyclodextrins
keywords: Biopesticides; Cyclodextrin; Miniaturized solid-phase extraction; Quadrupole time-of-flight mass spectrometry; Ultra-high-performance liquid chromatography