title: Hepatoprotective hemiterpene glycosides from the rhizome of Cibotium barometz (L.) J. Sm.
abstract: Five previously undescribed hemiterpene glycosides, cibotiumbarosides E-I, and two known hemiterpene glucosides, were isolated from the rhizome of Cibotium barometz (L.) J. Sm. The structures of cibotiumbarosides E-I were established by 1D and 2D NMR spectroscopic analyses and HRMS. The absolute configuration of the aglycone of cibotiumbaroside E was assigned by calculated ECD with the TDDFT method. Cibotiumbarosides F and I both exhibited remarkable hepatoprotective activity against APAP-induced acute liver damage in vitro, which were more effective than the positive control, bicyclol. On the other hand, seven hemiterpene glycosides were all inactive in assays of cytotoxicity, neuroprotection, antidiabetes and anti-inflammation.
authors.affiliation: State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Mei-Ping
authors.initials: MP
authors.lastname: Xie
authors.affiliation: State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Li
authors.affiliation: State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: An-Qi
authors.initials: AQ
authors.lastname: Lu
authors.affiliation: State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Jian-Gong
authors.initials: JG
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: sujuanwang@imm.ac.cn.
authors.forename: Su-Juan
authors.initials: SJ
authors.lastname: Wang
mesh_terms: D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D045782:Hemiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry*; D064028:Tracheophyta / Q000737:chemistry*
chemical_list: D006027:Glycosides; D045782:Hemiterpenes; D010936:Plant Extracts
keywords: Cibotium barometz (L.) J. Sm.; Dicksoniaceae; Hemiterpene glycosides; Hepatoprotection