title: Effect of microbial siderophores on mammalian non-malignant and malignant cell lines.
abstract: BACKGROUND
  Iron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment.
  
  
  METHODS
  In the present study, we have evaluated effect of three siderophores - exochelin-MS, mycobactin S and deferoxamine B on the proliferation of mammalian cell lines using MTT assay.
  
  
  RESULTS
  These siderophores caused a significant decrease in the viability of malignant cells, without significantly affecting non-malignant cells.
  
  
  CONCLUSIONS
  Based on these results, we suggest that iron-chelation therapy could be explored as an adjunctive therapeutic option against cancer along with other therapies.
authors.affiliation: Department of Microbiology, Sir Hurkisondas Nurrotumdas Medical Research Society, Mumbai, 400 002, India. karuna.gokarn@xaviers.edu.|Caius Research Laboratory, St. Xavier's College, Mumbai, 400 001, India. karuna.gokarn@xaviers.edu.
authors.forename: Karuna
authors.identifier: http://orcid.org/0000-0002-4416-4328
authors.initials: K
authors.lastname: Gokarn
authors.affiliation: Caius Research Laboratory, St. Xavier's College, Mumbai, 400 001, India.
authors.forename: Vishwas
authors.initials: V
authors.lastname: Sarangdhar
authors.affiliation: Department of Microbiology, Sir Hurkisondas Nurrotumdas Medical Research Society, Mumbai, 400 002, India.
authors.forename: Ramprasad B
authors.initials: RB
authors.lastname: Pal
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003676:Deferoxamine / Q000494:pharmacology; D006801:Humans; D051379:Mice; D010080:Oxazoles / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000494:pharmacology; D017262:Siderophores / Q000494:pharmacology*
chemical_list: D010080:Oxazoles; D010456:Peptides, Cyclic; D017262:Siderophores; C018608:mycobactins; D003676:Deferoxamine
keywords: Deferoxamine B; Exochelin-MS; MTT assay; Mammalian cell lines; Mycobactin S; Siderophores