title: Automated and reconfigurable platform for niosome generation based on a microfluidic architecture.
abstract: Drug delivery at the nano-scale is becoming an important topic in nano and regenerative medicine as it can offer a very localized therapy. Therefore, niosomes are one of the most important vehicles to release drug at the nanoscale. In this paper, we present a new automated microsystem for niosome generation on-demand. Used niosome were based on a mixture of cholesterol and dicetyl phosphate with chloroform. Three compact micropumps are connected to a microfluidic substrate in order to generate 100 nm noisome vesicles. Through this paper we also investigated the impact of using 150 μm pseudo-Y and cross shape microchannel on the diameter of vesicles. We have observed reliable results with Y-shaped microchannel, which was able to generate vesicles down to 91 nm. All the system is based on a low-cost fabrication process using dry photo resist.
authors.forename: Frederic
authors.initials: F
authors.lastname: Tessier
authors.forename: Myriam
authors.initials: M
authors.lastname: Laprise-Pelletier
authors.forename: Eric
authors.initials: E
authors.lastname: Boilard
authors.forename: Marc-Andre
authors.initials: MA
authors.lastname: Fortin
authors.forename: Amine
authors.initials: A
authors.lastname: Miled
mesh_terms: D001331:Automation; D002784:Cholesterol / Q000737:chemistry; D016503:Drug Delivery Systems; D004581:Electronics; D008081:Liposomes / Q000737:chemistry*; D044085:Microfluidics / Q000379:methods*; D010755:Organophosphates / Q000737:chemistry; D012996:Solutions
chemical_list: D008081:Liposomes; D010755:Organophosphates; D012996:Solutions; C002290:dicetylphosphate; D002784:Cholesterol