title: Efficient Synthesis of Fused Oxazepino-isoquinoline Scaffolds via an Ugi, Followed by an Intramolecular Cyclization.
abstract: A mild and efficient protocol was developed for the synthesis of oxazepino-isoquinolines via a one-pot Ugi four-component reaction, followed by the intramolecular addition of the resulting alcohol to an alkyne moiety under microwave irradiation conditions. Notably, this process only required one purification step, providing facile access to two series of complex and potentially interesting biologically active scaffolds.
authors.affiliation: Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.|Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences . Chengdu 610041, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Jiang-Ping
authors.initials: JP
authors.lastname: Meng
authors.affiliation: Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.|Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences . Chengdu 610041, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Lei
authors.affiliation: Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Zhong-Zhu
authors.initials: ZZ
authors.lastname: Chen
authors.affiliation: Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Dian-Yong
authors.initials: DY
authors.lastname: Tang
authors.affiliation: Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.|Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences . Chengdu 610041, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Zhi-Gang
authors.identifier: 0000-0003-0190-1313
authors.initials: ZG
authors.lastname: Xu
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D003500:Cyclization; D006801:Humans; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D010077:Oxazepines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000480:Alkynes; D007546:Isoquinolines; D010077:Oxazepines
keywords: Ugi reaction; alcohol addition; hydroxyisoquinolines; multicomponent reactions; oxazepino-isoquinoline