title: Rapidly progressing facial leishmaniasis: effective treatment with liposomal amphotericin B and a review of the management of Old World cutaneous leishmaniasis.
abstract: Cutaneous leishmaniasis (CL), a common condition in many parts of the world, is being increasingly encountered in non-endemic countries secondary to immigration. The clinical manifestations and course can vary substantially, with appropriate management ranging from observation for self-healing lesions to urgent treatment to prevent damaging anatomical and cosmetic sequelae. While there are now several effective medications, optimal therapy is not well defined, and decision-making can be challenged by the location of lesions and various drug issues, including availability, mode of delivery and adverse effects. A 7-year-old Afghani boy who presented shortly after arriving in the United States with a rapidly progressing crusting and ulcerative facial rash caused by Leishmania tropica is described. The various drugs currently available for CL and experience of using liposomal amphotericin B specifically are reviewed.
authors.affiliation: a Division of Pediatric Infectious Diseases , University at Buffalo, State University of New York , Buffalo , NY , USA.
authors.forename: Shamim
authors.initials: S
authors.lastname: Islam
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage*; D000981:Antiprotozoal Agents / Q000008:administration & dosage*; D002648:Child; D005148:Facial Dermatoses / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D007895:Leishmania tropica / Q000302:isolation & purification*; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D016896:Treatment Outcome; D014481:United States
chemical_list: D000981:Antiprotozoal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B
keywords: Cutaneous leishmaniasis; Leishmania tropica; immigrant and refugee health; liposomal amphotericin B (L-Amb)