title: Abscopal effect of metastatic pancreatic cancer after local radiotherapy and granulocyte-macrophage colony-stimulating factor therapy.
abstract: The role of immunotherapy in combination with traditional treatment regime in improving the survival of cancer patients has attracted more and more attention. Especially the abscopal effect that describes the phenomenon of localized radiotherapy leading to regression of distant unirradiated tumors and the role of enhanced radiotherapy-induced immunogenic cell death and activation of immune system have become a focus of the studies. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known a powerful stimulator of the generation, migration and activation of antigen presenting cells such as dendritic cells (DC) and macrophages. Here we report a case of a 67-year-old refractory metastatic pancreatic cancer patient who obtained evident abscopal effect and survival benefit from concurrent localized radiotherapy and GM-CSF.
authors.affiliation: a Department of Radiation Oncology , Shandong Cancer Hospital and Institute , Jinan , Shandong Province , China.
authors.forename: Fang
authors.initials: F
authors.lastname: Shi
authors.affiliation: a Department of Radiation Oncology , Shandong Cancer Hospital and Institute , Jinan , Shandong Province , China.|b School of Medicine and Life Sciences , University of Jinan-Shandong Academy of Medical Sciences , Jinan , Shandong Province , China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Department of Radiation Oncology , Shandong Cancer Hospital and Institute , Jinan , Shandong Province , China.|c School of Medicine, Shandong University , Jinan , Shandong Province , China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Teng
authors.affiliation: a Department of Radiation Oncology , Shandong Cancer Hospital and Institute , Jinan , Shandong Province , China.
authors.forename: Li
authors.initials: L
authors.lastname: Kong
authors.affiliation: a Department of Radiation Oncology , Shandong Cancer Hospital and Institute , Jinan , Shandong Province , China.|c School of Medicine, Shandong University , Jinan , Shandong Province , China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Yu
mesh_terms: D000368:Aged; D059248:Chemoradiotherapy; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor
keywords: Abscopal effect; CD8+ T cell; GM-CSF; dentritic cell; hypofractionated radiation