title: Pediatric follicular lymphoma in Japan.
abstract: Follicular lymphoma (FL) is quite rare in children. There have been only two major reports on pediatric FL. The present retrospective study on pediatric FL in Japan, including FL with diffuse large B cell lymphoma (DLBCL), analyzed data from 1991 to 2014. Twenty-two patients with pediatric FL were analyzed. Sixteen patients were boys and six were girls. Median age of onset was 9 years (range 4-17 years). In 11 patients, DLBCL co-existed with FL. The initial lesions involved cervical lesions in 16 patients, and the abdomen in six. With regard to stage of disease at diagnosis, 17 patients were at stage I or II, four were at stage III, and one was at stage IV. Chemotherapy was administered in 18 patients, and only resection was performed in four patients. Mature B lymphoma regimens were selected for 17 patients who received chemotherapy. Although two patients relapsed, all patients are currently alive and disease free. The median follow-up period was 54.5 months (range 6-126 months). Patients having FL with DLBCL were younger compared with those having FL, and this disease was more frequently observed in female patients. Our data revealed that FL in Japanese children is a tumor with good prognosis, as in reports from the United States and Europe.
authors.affiliation: Department of Pediatrics, Sapporo Hokuyu Hospital, Higashi-Sapporo 6-6, Shiroishiku, Sapporo, Hokkaido, 003-0006, Japan. r-koba@jacls.jp.|Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan. r-koba@jacls.jp.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kobayashi
authors.affiliation: Department of Pediatrics, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Tanaka
authors.affiliation: Department of Pathology, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nakazawa
authors.affiliation: Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Ueyama
authors.affiliation: Department of Pediatrics, Japanese Red Cross Narita Hospital, Narita, Japan.
authors.forename: Shosuke
authors.initials: S
authors.lastname: Sunami
authors.affiliation: Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Mitsui
authors.affiliation: Department of Pediatrics, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Koga
authors.affiliation: Department of Pediatrics, Kobe University School of Medicine, Kobe, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mori
authors.affiliation: Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Tomoo
authors.initials: T
authors.lastname: Osumi
authors.affiliation: Department of Pediatrics, National Hospital Organization Kyusyu Cancer Center, Fukuoka, Japan.
authors.forename: Reiji
authors.initials: R
authors.lastname: Fukano
authors.affiliation: Department of Hematology and Oncology, Gunma Children's Medical Center, Shibukawa, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ohki
authors.affiliation: Department of Pediatrics, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sekimizu
authors.affiliation: Department of Pediatrics, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Fujita
authors.affiliation: Department of Pediatrics, School of Medicine, Nagoya City University, Nagoya, Japan.
authors.forename: Michi
authors.initials: M
authors.lastname: Kamei
authors.affiliation: Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mori
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012737:Sex Factors
keywords: Childhood; Follicular lymphoma; Pediatric follicular lymphoma