title: Polysulfone hemodiafiltration membranes with enhanced anti-fouling and hemocompatibility modified by poly(vinyl pyrrolidone) via in situ cross-linked polymerization.
abstract: Poly(vinyl pyrrolidone) (PVP) and its copolymers have been widely employed for the modification of hemodiafiltration membranes due to their excellent hydrophilicity, antifouling and hemocompatibility. However, challenges still remain to simplify the modification procedure and to improve the utilization efficiency. In this paper, antifouling and hemocompatibility polysulfone (PSf) hemodiafiltration membranes were fabricated via in situ cross-linked polymerization of vinyl pyrrolidone (VP) and vinyltriethoxysilane (VTEOS) in PSf solutions and non-solvent induced phase separation (NIPS) technique. The prepared membranes were characterized by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM), which suggested that VP and VTEOS have been cross-linked copolymerized in PSf membranes. The modified PSf membranes with high polymer content showed improved hydrophilicity, ultrafiltration and protein antifouling ability. In addition, the modified PSf membranes showed lower protein adsorption, inhibited platelet adhesion and deformation, prolonged the activated partial thromboplastin time (APTT), prothrombin time (PT), and decreased the content of fibrinogen (FIB) transferring to fibrin, indicating enhanced hemocompatibility. In a word, the present work provides a simple and effective one-step modification method to construct PSf membranes with improved hydrophilicity, antifouling and hemocompatibility.
authors.affiliation: Polymer and Composite Division, Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China. Electronic address: zhulijing@nimte.ac.cn.
authors.forename: Lijing
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Polymer and Composite Division, Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China.
authors.forename: Haiming
authors.initials: H
authors.lastname: Song
authors.affiliation: Polymer and Composite Division, Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China.
authors.forename: Jiarong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Polymer and Composite Division, Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China. Electronic address: xuelx@nimte.ac.cn.
authors.forename: Lixin
authors.initials: L
authors.lastname: Xue
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D057219:Biofouling / Q000517:prevention & control; D001792:Blood Platelets / Q000166:cytology; D002448:Cell Adhesion / Q000187:drug effects; D017583:Hemodiafiltration; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D010314:Partial Thromboplastin Time; D056951:Photoelectron Spectroscopy; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D011143:Polyvinyl Chloride / Q000737:chemistry*; D016062:Porosity; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D011517:Prothrombin Time; D017550:Spectroscopy, Fourier Transform Infrared; D013450:Sulfones / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011108:Polymers; D011506:Proteins; D013450:Sulfones; C017662:polysulfone P 1700; D011143:Polyvinyl Chloride
keywords: Anti-fouling; Hemocompatibility; In situ cross-linked polymerization; Poly(vinyl pyrrolidone); Polysulfone hemodiafiltration membranes