title: Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats.
abstract: Several studies have shown that a high consumption of vegetables and fruits is consistently associated with a low risk of oxidative stress-induced diseases, which includes some degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer and Parkinson. Therefore, the objective of this study is to verify the effects of conventional and organic grape juice in the modulation of the neurotrophic factor (BDNF) and astrocytic markers protein (S100B) in hippocampus and frontal cortex of Wistar rats. In this study, 24 male Wistar rats were divided into three groups. To the first one, it was given organic purple grape juice; to the second, conventional grape juice, while the last one received only saline. After 30 days, all rats were sacrificed and hippocampus and frontal cortex were dissected. The animals that received organic and conventional grape juice showed, in frontal cortex, an elevated BNDF levels in relation to saline group. However, S100B levels did not change. These results showed that grape juices are able to modulate important marker in brain tissue, and could be an important factor to prevent brain diseases.
authors.affiliation: Instituto de Biotecnologia, Universidade de Caxias do Sul/UCS, Rua Francisco Getúlio Vargas, 1130, 95070-560 Caxias do Sul, RS, Brazil.|Centro Universitário Metodista IPA, Rua Joaquim Pedro Salgado, 80, Rio Branco, 90420-060 Porto Alegre, RS, Brazil.
authors.forename: Caroline
authors.initials: C
authors.lastname: Dani
authors.affiliation: Department of Psychiatry, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8 Canada.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Andreazza
authors.affiliation: Universidade Federal do Rio Grande do Sul/UFRGS, Avenida Ramiro Barcelos, 2350, 90035-903 Porto Alegre, RS, Brazil.
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Gonçalves
authors.affiliation: Universidade Federal do Rio Grande do Sul/UFRGS, Avenida Ramiro Barcelos, 2350, 90035-903 Porto Alegre, RS, Brazil.
authors.forename: Flávio
authors.initials: F
authors.lastname: Kapizinski
authors.affiliation: Instituto de Biotecnologia, Universidade de Caxias do Sul/UCS, Rua Francisco Getúlio Vargas, 1130, 95070-560 Caxias do Sul, RS, Brazil.
authors.forename: João A P
authors.initials: JAP
authors.lastname: Henriques
authors.affiliation: Instituto de Biotecnologia, Universidade de Caxias do Sul/UCS, Rua Francisco Getúlio Vargas, 1130, 95070-560 Caxias do Sul, RS, Brazil.
authors.forename: Mirian
authors.initials: M
authors.lastname: Salvador
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D019208:Brain-Derived Neurotrophic Factor / Q000032:analysis* / Q000187:drug effects; D058870:Food, Organic; D005625:Frontal Lobe / Q000737:chemistry* / Q000187:drug effects; D000067030:Fruit and Vegetable Juices; D006624:Hippocampus / Q000737:chemistry* / Q000187:drug effects; D008297:Male; D011897:Random Allocation; D017208:Rats, Wistar; D012016:Reference Values; D015203:Reproducibility of Results; D064568:S100 Calcium Binding Protein beta Subunit / Q000032:analysis* / Q000187:drug effects; D027843:Vitis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D019208:Brain-Derived Neurotrophic Factor; D064568:S100 Calcium Binding Protein beta Subunit; C579158:S100b protein, rat