title: Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions.
abstract: Mitochondrial Carrier Homolog 2 (MTCH2) is a novel regulator of mitochondria metabolism, which was recently associated with Alzheimer's disease. Here we demonstrate that deletion of forebrain MTCH2 increases mitochondria and whole-body energy metabolism, increases locomotor activity, but impairs motor coordination and balance. Importantly, mice deficient in forebrain MTCH2 display a deficit in hippocampus-dependent cognitive functions, including spatial memory, long term potentiation (LTP) and rates of spontaneous excitatory synaptic currents. Moreover, MTCH2-deficient hippocampal neurons display a deficit in mitochondria motility and calcium handling. Thus, MTCH2 is a critical player in neuronal cell biology, controlling mitochondria metabolism, motility and calcium buffering to regulate hippocampal-dependent cognitive functions.
authors.affiliation: Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Antonella
authors.initials: A
authors.lastname: Ruggiero
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Etay
authors.initials: E
authors.lastname: Aloni
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Eduard
authors.initials: E
authors.lastname: Korkotian
authors.affiliation: Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Yehudit
authors.initials: Y
authors.lastname: Zaltsman
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Efrat
authors.initials: E
authors.lastname: Oni-Biton
authors.affiliation: Department of Veterinary Resources, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Kuperman
authors.affiliation: Department of Veterinary Resources, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Tsoory
authors.affiliation: Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Liat
authors.initials: L
authors.lastname: Shachnai
authors.affiliation: Department of Chemical research Support, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Smadar
authors.initials: S
authors.lastname: Levin-Zaidman
authors.affiliation: Department of Veterinary Resources, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Ori
authors.initials: O
authors.lastname: Brenner
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Menahem
authors.initials: M
authors.lastname: Segal
authors.affiliation: Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Atan
authors.initials: A
authors.lastname: Gross
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003071:Cognition / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000378:metabolism* / Q000503:physiopathology; D008124:Locomotion / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D033681:Mitochondrial Membrane Transport Proteins / Q000172:deficiency / Q000235:genetics*; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D004856:Postural Balance / Q000502:physiology; D016548:Prosencephalon / Q000378:metabolism / Q000503:physiopathology; D011596:Psychomotor Disorders / Q000378:metabolism / Q000503:physiopathology; D045442:Rotarod Performance Test; D065852:Spatial Memory / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D033681:Mitochondrial Membrane Transport Proteins; C550380:Mtch2 protein, mouse; D002118:Calcium