title: Perioperative risk factors for death among patients with symptomatic pulmonary thromboembolism.
abstract: Perioperative pulmonary thromboembolism (PTE) is a fatal complication that may occur in patients who are undergoing surgery. This study aimed to identify risk factors for PTE-related death. This study evaluated data for the most recent 5-year period (2007-2011) from the Japanese Society of Anesthesiologists' database of patients who experienced perioperative PTE. We compared patients who died within 30 days of onset and patients who survived for > 30 days, and used logistic regression analysis to identify the independent risk factors. We identified 1894 patients who experienced PTE; 294 patients died within 30 days and 1600 patients survived for > 30 days. Univariate analyses revealed that PTE-related death was significantly associated with male sex, an age of ≥ 80 years, bedridden status, and trauma or heart failure. Survival was significantly associated with the use of anticoagulant therapy, obesity, and a recent history of venous thromboembolism. Logistic regression analyses revealed that male sex, an age of ≥ 80 years, bedridden status, heart failure, and the non-use of anticoagulant therapy were independent risk factors for PTE-related death. We found that male sex, an age of ≥ 80 years, bedridden status, heart failure, and the non-use of anticoagulant therapy were independent risk factors for perioperative PTE-related death. Therefore, appropriate interventions for bedridden patients and thromboprophylaxis using anticoagulants may help reduce the incidence of perioperative PTE-related mortality.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage*; D005260:Female; D006333:Heart Failure / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D009765:Obesity / Q000150:complications; D011183:Postoperative Complications / Q000453:epidemiology*; D011655:Pulmonary Embolism / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000453:epidemiology*
chemical_list: D000925:Anticoagulants
keywords: Case fatality rate; Immobilization; Perioperative risk factors; Prevention; Pulmonary thromboembolism; Thromboprophylaxis