title: Ultrasound-guided spectral photoacoustic imaging of hemoglobin oxygenation during development.
abstract: Few technologies are capable of imagingin vivofunction during development. In this study, we have implemented spectral photoacoustic imaging to estimate tissue oxygenation longitudinally in pregnant mice. We used the spectral photoacoustic signal to estimate hemoglobin oxygen saturation within intact,in vivomouse concepti from developmental day (E) 8.5 to E16.5-a first step towards functional imaging of the maternal-fetal environment. Future work will apply these methods to compare longitudinal functional changes during normal vs abnormal development of embryos, fetuses, and placentas.
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, Austin, TX 78712, USA; Currently with the Department of Biomedical Engineering, Tulane University, 500 Lindy Boggs Center, New Orleans, LA 70118, USA.
authors.forename: Carolyn L
authors.initials: CL
authors.lastname: Bayer
authors.affiliation: Dell Pediatric Research Institute, Department of Nutritional Sciences, The University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA.
authors.forename: Bogdan J
authors.initials: BJ
authors.lastname: Wlodarczyk
authors.affiliation: Dell Pediatric Research Institute, Department of Nutritional Sciences, The University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA.
authors.forename: Richard H
authors.initials: RH
authors.lastname: Finnell
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, Austin, TX 78712, USA; Currently with the School of Electrical and Computer Engineering, Georgia Institute of Technology, 777 Atlantic Drive NW, Atlanta, GA 30332, USA.
authors.forename: Stanislav Y
authors.initials: SY
authors.lastname: Emelianov
keywords: (100.1830) Deconvolution; (170.2655) Functional monitoring and imaging; (170.5120) Photoacoustic imaging; (170.7170) Ultrasound