title: Soluble Triggering Receptor Expressed on Myeloid Cells-1 as a Novel Marker for Abdominal Sepsis.
abstract: BACKGROUND
  The aim of the study was to investigate the concentration and diagnostic significance of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in acute abdominal conditions.
  
  
  METHODS
  Plasma specimens were obtained from 68 patients with abdominal sepsis, 60 patients with systemic inflammatory response syndrome (SIRS), and 60 healthy individuals. The sepsis group was divided into the survival and death groups according to the 28-d outcome. Plasma sTREM-1, procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) count were measured. A receiver operating characteristic curve (ROC) was used to compare the diagnostic values of sTREM-1, PCT, CRP, and WBC count. In addition, the correlation between plasma sTREM-1 and the Acute Physiology and Chronic Health Evaluation (APACHE) II score in the sepsis group was assessed by Spearman correlation analysis.
  
  
  RESULTS
  The plasma concentration of sTREM-1 in the sepsis group was significantly higher than that in the SIRS and healthy groups (both p < 0.001). Also, the plasma concentration of sTREM-1 in the death group was markedly higher than that in the survival group. The ROC for the diagnosis of sepsis vs. SIRS showed that the area under the curve of sTREM-1 (0.82) was greater than that of PCT (0.77), CRP (0.72), and WBC count (0.70). Additionally, in the sepsis group, the plasma sTREM-1 concentration correlated positively with the APACHE II score (r = 0.41; p < 0.05).
  
  
  CONCLUSIONS
  The plasma concentration of sTREM-1 may be a significantly sensitive and useful indicator for the rapid diagnosis of abdominal sepsis.
authors.affiliation: 1 Department of Gastrointestinal Surgery, The People's Hospital of Zhengzhou University (Henan Provincial People's Hospital) , Zhengzhou, People's Republic of China .
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Song
authors.affiliation: 1 Department of Gastrointestinal Surgery, The People's Hospital of Zhengzhou University (Henan Provincial People's Hospital) , Zhengzhou, People's Republic of China .
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Song
authors.affiliation: 1 Department of Gastrointestinal Surgery, The People's Hospital of Zhengzhou University (Henan Provincial People's Hospital) , Zhengzhou, People's Republic of China .
authors.forename: Xuedong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: 2 Department of Hepatobiliary Surgery, The People's Hospital of Zhengzhou University (Henan Provincial People's Hospital) , Zhengzhou, People's Republic of China .
authors.forename: Huanzhou
authors.initials: H
authors.lastname: Xue
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002116:Calcitonin / Q000097:blood; D005260:Female; D006801:Humans; D059413:Intraabdominal Infections / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D012372:ROC Curve; D011971:Receptors, Immunologic / Q000097:blood*; D018805:Sepsis / Q000097:blood / Q000175:diagnosis*; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D015415:Biomarkers; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D002116:Calcitonin
keywords: abdominal sepsis; procalcitonin; soluble triggering receptor expressed on myeloid cells-1