title: Contemporary use of drug-coated balloons in coronary artery disease: Where are we now?
abstract: The drug-coated balloon (DCB) has emerged as an additional tool in the arsenal of interventional cardiology devices; it delivers antiproliferative drugs to local arterial tissue by single prolonged coated balloon angioplasty inflation, and prevents restenosis, leaving no implant behind. This strategy theoretically decreases the risk of late inflammatory response to device components, without preventing positive remodelling. DCBs, when used carefully and with a good technique, may have a role in the treatment of lesion subsets, such as in-stent restenosis, small vessel disease or side branch bifurcations, in which the implantation of a drug-eluting stent is not desirable or is technically challenging. Using the latest evidence regarding the effectiveness of the currently available DCBs, this review will discuss the rationale for DCB use, and the effectiveness of DCBs in different clinical and lesion settings, and will give practical tips for their correct use in everyday clinical practice.
authors.affiliation: Interventional cardiology division, department of medicine, Montreal heart institute, université de Montréal, 5000 Bélanger, H1T 1C8 Montréal, QC, Canada; Interventional cardiology department, Cochin hospital, Assistance publique-Hôpitaux de Paris, Paris, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Picard
authors.affiliation: Interventional cardiology division, department of medicine, Montreal heart institute, université de Montréal, 5000 Bélanger, H1T 1C8 Montréal, QC, Canada.
authors.forename: Serge
authors.initials: S
authors.lastname: Doucet
authors.affiliation: Interventional cardiology division, department of medicine, Montreal heart institute, université de Montréal, 5000 Bélanger, H1T 1C8 Montréal, QC, Canada. Electronic address: anita.asgar@umontreal.ca.
authors.forename: Anita W
authors.initials: AW
authors.lastname: Asgar
mesh_terms: D062906:Cardiac Catheters; D002317:Cardiovascular Agents / Q000008:administration & dosage* / Q000009:adverse effects; D020099:Coated Materials, Biocompatible; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D023903:Coronary Restenosis / Q000209:etiology; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D004867:Equipment Design; D006801:Humans; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D020099:Coated Materials, Biocompatible
keywords: Angioplastie percutanée; Athérosclérose; Ballon médicamenté; Drug-coated balloon; Drug-eluting balloon; In-stent restenosis; Paclitaxel; Percutaneous coronary intervention; Resténose intra-stent