title: Medically unexplained visual loss in children and young people: an observational single site study of incidence and outcomes.
abstract: PurposeTo determine the incidence of medically unexplained visual loss (MUVL) in children in an open access children's eye casualty.Patients and methodsWe collated demographic and clinical data of consecutive patients younger than 16 years who presented to the children's eye casualty at Moorfields Eye Hospital over a 12-month period and were diagnosed with MUVL or suspected MUVL. We reviewed the clinical records at least 3 months after initial presentation. We calculated the incidence using the number of 'new patient' attendances over the same period as denominator (n=2397). We used descriptive analysis.
  
  
  METHODS
  number of patients diagnosed with MUVL, proportion of patients with a history of or present psychological problems, recovery rate, and improvement in visual acuity.ResultsWe identified 85 cases of MUVL (54 females; median age: 9 years (IQR 7-12)). The median duration of follow-up was 1.2 months (IQR 0-4.3). The estimated annual incidence was 3.5% (95% confidence interval 2.9-4.4%). Thirty-three per cent of children had a history of psychiatric disorders, reported a stressful life event, or showed signs of psychiatric disorder at the time of first presentation. The recovery rate was 25%. Median improvement in best-corrected visual acuity from presentation to last appointment was 0.22 (IQR 0.06-0.43) logMAR.ConclusionThe incidence of MUVL is higher and the rate of resolution lower than previously reported. MUVL may be associated with mental health problems. We recommend screening for psychological problems to facilitate access to psychological treatment.
authors.affiliation: NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.|Eye Center, Medical Center, University of Freiburg, Freiburg, Germany.
authors.forename: M C
authors.initials: MC
authors.lastname: Daniel
authors.affiliation: Great Ormond Street Hospital for Children NHS Foundation Trust, University College London, Institute of Child Health, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Coughtrey
authors.affiliation: Great Ormond Street Hospital for Children NHS Foundation Trust, University College London, Institute of Child Health, London, UK.
authors.forename: I
authors.initials: I
authors.lastname: Heyman
authors.affiliation: NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
authors.forename: A H
authors.initials: AH
authors.lastname: Dahlmann-Noor
mesh_terms: D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D011379:Prognosis; D011618:Psychotic Disorders / Q000150:complications* / Q000453:epidemiology; D012042:Registries; D013315:Stress, Psychological / Q000150:complications* / Q000453:epidemiology; D063189:Symptom Assessment / Q000379:methods*; D013997:Time Factors; D006113:United Kingdom / Q000453:epidemiology; D014786:Vision Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D014792:Visual Acuity