title: Reversal of endothelial dysfunction in aorta of streptozotocin-nicotinamide-induced type-2 diabetic rats by S-Allylcysteine.
abstract: Dietary measures and plant-based therapies as prescribed by native systems of medicine have gained attraction among diabetics with claims of efficacy. The present study investigated the effects of S-Allylcysteine (SAC) on body weight gain, glucose, insulin, insulin resistance, and nitric oxide synthase in plasma and argininosuccinate synthase (AS) and argininosuccinate lyase (ASL), lipid peroxides and antioxidant enzymes in aorta of control and streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats. Changes in body weight, glucose, insulin, insulin resistance, and antioxidant profiles of aorta and mRNA expressions of nitric oxide synthase, AS, and ASL were observed in experimental rats. SAC (150 mg/kg b.w) showed its therapeutic effects similar to gliclazide in decreasing glucose, insulin resistance, lipid peroxidation, and increasing body weight; insulin, antioxidant enzymes, and mRNA levels of nitric oxide synthase, argininosuccinate synthase, and argininosuccinate lyase genes in STZ-NA rats. Histopathologic studies also revealed the protective nature of SAC on aorta. In conclusion, garlic and its constituents mediate the anti-diabetic potential through mitigating hyperglycemic status, changing insulin resistance by alleviating endothelial dysregulation in both plasma and tissues.
authors.affiliation: Department of Biotechnology, Vikrama Simhapuri University, Nellore, Andhra Pradesh, India.
authors.forename: Parim
authors.initials: P
authors.lastname: Brahmanaidu
authors.affiliation: Department of Biochemistry, Centre for Biological Sciences, K.S. Rangasamy College of Arts and Science (Autonomous), Thokkavadi, Tiruchengode, Tamil Nadu, 637215, India.
authors.forename: V V Sathibabu
authors.initials: VVS
authors.lastname: Uddandrao
authors.affiliation: Department of Biochemistry, Centre for Biological Sciences, K.S. Rangasamy College of Arts and Science (Autonomous), Thokkavadi, Tiruchengode, Tamil Nadu, 637215, India.
authors.forename: Vadivukkarasi
authors.initials: V
authors.lastname: Sasikumar
authors.affiliation: National Center for Laboratory Animal Sciences, National Institute of Nutrition (ICMR-New Delhi), Hyderabad, India.
authors.forename: Ramavat Ravindar
authors.initials: RR
authors.lastname: Naik
authors.affiliation: National Center for Laboratory Animal Sciences, National Institute of Nutrition (ICMR-New Delhi), Hyderabad, India.
authors.forename: Suresh
authors.initials: S
authors.lastname: Pothani
authors.affiliation: Department of Biochemistry, Muthayammal College of Arts and Science, Rasipuram, Namakkal, Tamil Nadu, 637408, India.
authors.forename: Mustapha Sabana
authors.initials: MS
authors.lastname: Begum
authors.affiliation: Department of Biotechnology, K.S. Rangasamy College of Arts and Science, Thokkavadi, Tiruchengode, Tamil Nadu, 637215, India.
authors.forename: M Prasanna
authors.initials: MP
authors.lastname: Rajeshkumar
authors.affiliation: Department of Biotechnology, K.S. Rangasamy College of Arts and Science, Thokkavadi, Tiruchengode, Tamil Nadu, 637215, India.
authors.forename: Chandrasekar
authors.initials: C
authors.lastname: Varatharaju
authors.affiliation: Animal Physiology & Biochemistry Lab, Department of Biochemistry, Sri Venkateswara University, Tirupati, 517502, India.
authors.forename: Balaji
authors.initials: B
authors.lastname: Meriga
authors.affiliation: Department of Biochemistry, Centre for Biological Sciences, K.S. Rangasamy College of Arts and Science (Autonomous), Thokkavadi, Tiruchengode, Tamil Nadu, 637215, India.
authors.forename: P
authors.initials: P
authors.lastname: Rameshreddy
authors.affiliation: Department of Biochemistry, Centre for Biological Sciences, K.S. Rangasamy College of Arts and Science (Autonomous), Thokkavadi, Tiruchengode, Tamil Nadu, 637215, India.|Department of Biochemistry, PGP College of Arts and Science, Namakkal, Tamil Nadu, India.
authors.forename: A
authors.initials: A
authors.lastname: Kalaivani
authors.affiliation: Department of Biochemistry, Centre for Biological Sciences, K.S. Rangasamy College of Arts and Science (Autonomous), Thokkavadi, Tiruchengode, Tamil Nadu, 637215, India. saravana_bioc@rediffmail.com.
authors.forename: Ganapathy
authors.initials: G
authors.lastname: Saravanan
mesh_terms: D000818:Animals; D001011:Aorta / Q000378:metabolism* / Q000473:pathology; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: C065299:S-allylcysteine; D003545:Cysteine
keywords: Aorta; Diabetes; Diabetic cardiomyopathy; Lipid peroxidation; S-Allylcysteine; Streptozotocin