title: I2-Promoted formal [3+2] cycloaddition of α-methylenyl isocyanides with methyl ketones: a route to 2,5-disubstituted oxazoles.
abstract: An I2-promoted formal [3+2] cycloaddition for access to oxazoles has been demonstrated. This is the first example of a Lewis acid-promoted formal [3+2] cycloaddition of isocyanides with methyl ketones involving the C[triple bond, length as m-dash]N cleavage of isocyanides. The salient feature of this approach is unconventional 2,5-disubstituted oxazole formation from isocyanides and ketones rather than 4,5-substituted oxazoline.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, P. R. China. chwuyd@mail.ccnu.edu.cn chwuax@mail.ccnu.edu.cn.
authors.forename: Xia
authors.initials: X
authors.lastname: Wu
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, P. R. China. chwuyd@mail.ccnu.edu.cn chwuax@mail.ccnu.edu.cn.
authors.forename: Xiao
authors.initials: X
authors.lastname: Geng
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, P. R. China. chwuyd@mail.ccnu.edu.cn chwuax@mail.ccnu.edu.cn.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, P. R. China. chwuyd@mail.ccnu.edu.cn chwuax@mail.ccnu.edu.cn.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, P. R. China. chwuyd@mail.ccnu.edu.cn chwuax@mail.ccnu.edu.cn.
authors.forename: Yan-Dong
authors.identifier: http://orcid.org/0000-0001-7673-210X
authors.initials: YD
authors.lastname: Wu
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, P. R. China. chwuyd@mail.ccnu.edu.cn chwuax@mail.ccnu.edu.cn.
authors.forename: An-Xin
authors.initials: AX
authors.lastname: Wu