title: Monocyte Chemoattractant Protein-1 (MCP-1) as a Potential Therapeutic Target and a Noninvasive Biomarker of Liver Fibrosis Associated With Transient Myeloproliferative Disorder in Down Syndrome.
abstract: Liver fibrosis is one of the common complications of transient myeloproliferative disorder (TMD) in Down syndrome (DS), but the exact molecular pathogenesis is largely unknown. We herein report a neonate of DS with liver fibrosis associated with TMD, in which we performed the serial profibrogenic cytokines analyses. We found the active monocyte chemoattractant protein-1 expression in the affected liver tissue and also found that both serum and urinary monocyte chemoattractant protein-1 concentrations are noninvasive biomarkers of liver fibrosis. We also showed a prospective of the future anticytokine therapy with herbal medicine for the liver fibrosis associated with TMD in DS.
authors.affiliation: Departments of *Pediatrics ¶Pediatric Surgery #Diagnostic Pathology, Hyogo Prefectural Amagasaki General Medical Center, Hyogo Departments of †Pediatric Hematology and Oncology Research ‡Pathology, National Research Institute for Child Health and Development, Tokyo §Department of Pathology and Laboratory Medicine, Tokyo Dental College Ichikawa General Hospital, Chiba ∥Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Takako
authors.initials: T
authors.lastname: Yoshioka
authors.forename: Jun
authors.initials: J
authors.lastname: Miyauchi
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nakazawa
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ono
authors.forename: Michiko
authors.initials: M
authors.lastname: Tatsuno
authors.forename: Kenta
authors.initials: K
authors.lastname: Iijima
authors.forename: Chiaki
authors.initials: C
authors.lastname: Takahashi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Okada
authors.forename: Kenji
authors.initials: K
authors.lastname: Teranishi
authors.forename: Takaaki
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Chieko
authors.initials: C
authors.lastname: Matsushima
authors.forename: Mayo
authors.initials: M
authors.lastname: Inagaki
authors.forename: Minoru
authors.initials: M
authors.lastname: Suehiro
authors.forename: Saori
authors.initials: S
authors.lastname: Suehiro
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nishitani
authors.forename: Hirohito
authors.initials: H
authors.lastname: Kubota
authors.forename: Jun
authors.initials: J
authors.lastname: Iio
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Nishida
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Katayama
authors.forename: Narito
authors.initials: N
authors.lastname: Takada
authors.forename: Kentaro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Ryoji
authors.initials: R
authors.lastname: Yasumizu
authors.forename: Kentaro
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ohki
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Kiyokawa
authors.forename: Toshiro
authors.initials: T
authors.lastname: Maihara
authors.forename: Ikuya
authors.initials: I
authors.lastname: Usami
mesh_terms: D015415:Biomarkers; D018932:Chemokine CCL2 / Q000032:analysis*; D016207:Cytokines / Q000032:analysis; D003937:Diagnosis, Differential; D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D007955:Leukemoid Reaction / Q000150:complications*; D008099:Liver / Q000737:chemistry / Q000473:pathology; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000209:etiology
chemical_list: D015415:Biomarkers; D018932:Chemokine CCL2; D016207:Cytokines