title: Hormonal and Metabolic Responses to a Single Bout of Resistance Exercise in Prader-Willi Syndrome .
abstract: BACKGROUND
  Prader-Willi syndrome (PWS) is characterized by excessive adiposity. Excess adiposity negatively affects hormonal and metabolic responses to aerobic exercise. This study determined whether PWS and/or adiposity affected hormonal and metabolic responses to resistance exercise.
  
  
  METHODS
  Eleven children with PWS (11.4 ± 3.1 years, 43.9 ± 7.5% body fat), 12 lean children (9.3 ± 1.4 years, 18.3 ± 4.9% body fat), and 13 obese children (9.6 ± 1.3 years, 40.3 ± 5.2% body fat) participated. The children stepped onto an elevated platform while wearing a weighted vest for 6 sets of 10 repetitions per leg (sets separated by 1 min of rest). For the children with PWS, the platform height was 23.0 cm and vest load was computed as (20% of stature × 50% of lean body mass)/23.0 cm. For the controls, the platform height was 20% of the stature and vest load 50% of the lean body mass. Blood samples were obtained before, immediately after, and during recovery from exercise (+15, +30, and +60 min).
  
  
  RESULTS
  All groups had similar catecholamine, insulin, and glucagon responses. The groups showed no major differences in glucose and lactate levels. The PWS children demonstrated earlier increases in fatty acids during recovery and higher glycerol and ketone levels than the controls.
  
  
  CONCLUSIONS
  The PWS children demonstrated largely intact hormonal, glycolytic, and lipolytic responses to lower-body resistance exercise. In PWS, elevated ketone levels suggest an incomplete fat oxidation. .
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Rubin
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Clark
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Haqq
authors.forename: Diobel M
authors.initials: DM
authors.lastname: Castner
authors.forename: Jason
authors.initials: J
authors.lastname: Ng
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Judelson
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002395:Catecholamines / Q000097:blood*; D002648:Child; D005260:Female; D005934:Glucagon / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D019344:Lactic Acid / Q000097:blood; D008297:Male; D011218:Prader-Willi Syndrome / Q000097:blood / Q000628:therapy; D055070:Resistance Training
chemical_list: D001786:Blood Glucose; D002395:Catecholamines; D007328:Insulin; D019344:Lactic Acid; D005934:Glucagon