title: Synthesis of Multifunctional Cationic Poly(p-phenylenevinylene) for Selectively Killing Bacteria and Lysosome-Specific Imaging.
abstract: In this work, a cationic polymer was synthesized to bear quaternized N-methyl-imidazole groups in the side chains. Positively charged PPV-M could selectively bind to Gram-negative and Gram-positive bacteria over fungi and exhibit enhanced antibacterial activity with the aid of white light because PPV-M could sensitize oxygen to generate reactive oxygen species (ROS) that would damage bacteria. In addition, green fluorescent and positively charged PPV-M has the ability to enter mammalian cells and be specifically accumulated in lysosome. Moreover, PPV-M could stay in live cells for a relatively long time, which implies that PPV-M has the potential to be a long-term imaging agent.
authors.affiliation: Department of Chemistry, School of Science, Beijing Technology and Business University , Beijing 100048, P. R. China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Chemistry, School of Science, Beijing Technology and Business University , Beijing 100048, P. R. China.
authors.forename: Huanxiang
authors.identifier: http://orcid.org/0000-0001-5344-3655
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Chemistry, School of Science, Beijing Technology and Business University , Beijing 100048, P. R. China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Liang
mesh_terms: D000818:Animals; D001419:Bacteria; D002412:Cations; D008247:Lysosomes; D011145:Polyvinyls / Q000737:chemistry*
chemical_list: D002412:Cations; D011145:Polyvinyls; C470024:poly(4-phenylenevinylene)
keywords: lysosome-specific imaging; multifunctional cationic polymer; photosensitizer; reactive oxygen species; selective antibacterial activity