title: Feasibility of gadoteric acid for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at the wrist and knee and comparison with Gd-DTPA.
abstract: To assess the feasibility of gadoteric acid for delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and to compare the dGEMRIC values obtained using gadoteric acid with those obtained by an equimolar dose of Gd-DTPA.
  
  
  
  At 3T, dGEMRIC of the wrist was performed twice using a T1-weighted 3D-volumetric interpolated breath-hold examination sequence in 16 healthy volunteers (10 women; mean age 26.0 years) using gadoteric acid first and Gd-DTPA 3 weeks later. In addition, 24 patients with knee pain were examined using gadoteric acid (n = 12; seven women; mean age 45.8 years) or Gd-DTPA (n = 12; four women; mean age 47.1 years). T1values, the relative decrease in T1, and the delta R1 were compared using t-tests. Interobserver agreement was assessed using the intraclass correlation (ICC) between two independent readers.
  
  
  
  At the wrist, there was no significant difference in delta R1 values (0.34 ± 0.10/s, 95% confidence interval [0.30;0.38]/s for gadoteric acid and 0.32 ± 0.09 [0.29;0.35]/s for Gd-DTPA, P = 0.24) or the relative decrease in T1(0.25 ± 0.06 [0.29;0.35] msec for gadoteric acid and 0.24 ± 0.05 [0.22;0.27] msec for Gd-DTPA, P = 0.35). High observer agreement was found at precontrast (ICC = 0.87, P < 0.001) and postcontrast (ICC = 0.89, P < 0.001). Similarly, at the knee, there was no significant difference in delta R1 (0.39 ± 0.18 [0.32;0.47]/s for gadoteric acid and 0.41 ± 0.09 [0.38;0.45]/s for Gd-DTPA, P = 0.59) or the relative decrease in T1(0.30 ± 0.10 [0.26;0.34] msec for gadoteric acid and 0.33 ± 0.05 [0.30;0.35] msec for Gd-DTPA, P = 0.28). High ICCs of 0.96 (P < 0.01) were noted both at precontrast and postcontrast.
  
  
  
  dGEMRIC using gadoteric acid is feasible and yields comparable values when compared with Gd-DTPA.
  
  
  
  2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1433-1440.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Rehnitz
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Germany.
authors.forename: Bastian
authors.initials: B
authors.lastname: Klaan
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Germany.
authors.forename: Thuy
authors.initials: T
authors.lastname: Do
authors.affiliation: Department of Orthopedics and Trauma Surgery, University Hospital Heidelberg, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Barié
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Germany.
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Germany.
authors.forename: Marc-André
authors.initials: MA
authors.lastname: Weber
mesh_terms: D000328:Adult; D000368:Aged; D002356:Cartilage / Q000000981:diagnostic imaging*; D015331:Cohort Studies; D003287:Contrast Media / Q000737:chemistry; D005260:Female; D005682:Gadolinium / Q000737:chemistry*; D019786:Gadolinium DTPA / Q000737:chemistry*; D064368:Healthy Volunteers; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006801:Humans; D007717:Knee / Q000000981:diagnostic imaging / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D009942:Organometallic Compounds / Q000737:chemistry*; D010146:Pain; D014953:Wrist / Q000000981:diagnostic imaging; D055815:Young Adult
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium; D019786:Gadolinium DTPA
keywords: Gd-DTPA; dGEMRIC; gadoteric acid; knee; wrist