title: Perspective on precision medicine in paediatric heart failure.
abstract: In 2015, President Obama launched the Precision Medicine Initiative (PMI), which introduced new funding to a method of research with the potential to study rare and complex diseases. Paediatric heart failure, a heterogeneous syndrome affecting approximately 1 in 100000 children, is one such condition in which precision medicine techniques may be applied with great benefit. Current heart failure therapies target downstream effects of heart failure rather than the underlying cause of heart failure. As such, they are often ineffective in paediatric heart failure, which is typically of primary (e.g. genetic) rather than secondary (e.g. acquired) aetiology. It is, therefore, important to develop therapies that can target the causes of heart failure in children with greater specificity thereby decreasing morbidity, mortality and burden of illness on both patients and their families. The benefits of co-ordinated research in genomics, proteomics, metabolomics, transcriptomics and phenomics along with dietary, lifestyle and social factors have led to novel therapeutic and prognostic applications in other fields such as oncology. Applying such co-ordinated research efforts to heart failure constitutes an important step in advancing care and improving the lives of those affected.
authors.affiliation: Division of Cardiology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Fridman
authors.affiliation: Division of Cardiology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8 seema.mital@sickkids.ca.
authors.forename: Seema
authors.initials: S
authors.lastname: Mital
mesh_terms: D002648:Child; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000379:methods; D006333:Heart Failure / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D057285:Precision Medicine / Q000379:methods*
keywords: cardiomyopathy; genomics; heart failure; paediatrics; precision medicine