title: Influence of enteral glutamine on inflammatory and hormonal response in patients with rectal cancer during preoperative radiochemotherapy.
abstract: We conducted a randomized double-blind placebo-controlled study evaluating the influence of 5 weeks' duration of 30 g enteral glutamine supplementation on inflammatory and hormonal responses in 73 patients with rectal cancer undergoing preoperative radiochemotherapy. Plasma levels of inflammatory and hormonal parameters were controlled at the beginning and at the end of supplementation. Enteral glutamine resulted in modulation of inflammatory and hormonal responses as shown by a decreased plasma interleukin 6 and cortisol levels in glutamine compared with placebo group: 5.5±3.8 versus 11.1±19.9 ng/l (P=0.02) for IL-6 and 386±168.4 to 312.7±111.7 nmol/l (P=0.03) for cortisol. We conclude that enteral glutamine exhibits some anti-inflammatory activity and, consequently, leads to a lower hormonal stress response during radiochemotherapy in patients with rectal cancer.
authors.affiliation: Institute of Oncology, Zaloška 2, Ljubljana, Slovenia Ljubljana.
authors.forename: N
authors.initials: N
authors.lastname: Rotovnik Kozjek
authors.affiliation: Institute of Oncology, Zaloška 2, Ljubljana, Slovenia Ljubljana.
authors.forename: L
authors.initials: L
authors.lastname: Kompan
authors.affiliation: Institute of Oncology, Zaloška 2, Ljubljana, Slovenia Ljubljana.
authors.forename: T
authors.initials: T
authors.lastname: Žagar
authors.affiliation: Department of Gastroenterology, Worthing Hospital WSHT, Worthing, UK.
authors.forename: Ž
authors.initials: Ž
authors.lastname: Mrevlje
mesh_terms: D000209:Acute-Phase Proteins; D000368:Aged; D015992:Body Mass Index; D002352:Carrier Proteins / Q000097:blood; D059248:Chemoradiotherapy; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D023381:Endpoint Determination; D004750:Enteral Nutrition; D005260:Female; D005973:Glutamine / Q000008:administration & dosage*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007249:Inflammation / Q000097:blood; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood; D008875:Middle Aged; D057947:Parenteral Nutrition Solutions; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000628:therapy*; D013739:Testosterone / Q000097:blood; D000099231:Lipopolysaccharide-Binding Protein
chemical_list: D000209:Acute-Phase Proteins; D002352:Carrier Proteins; D005973:Glutamine; D006854:Hydrocortisone; D007328:Insulin; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D057947:Parenteral Nutrition Solutions; D013739:Testosterone; D000099231:Lipopolysaccharide-Binding Protein; C508600:IL6 protein, human