title: Raman spectroscopy using plasmonic and carbon-based nanoparticles for cancer detection, diagnosis, and treatment guidance.Part 1: Diagnosis.
abstract: Optical techniques, including Raman, photothermal and photoacoustic microscopy and spectroscopy, have been intensively explored for the sensitive and accurate detection of various diseases. Rapid advances in lasers, photodetectors, and nanotechnology have led to the development of Raman spectroscopy, particularly surface-enhanced Raman scattering (SERS), as a promising imaging modality that can help diagnose many diseases. This review focuses on the major recent advances in Raman spectroscopy and SERS-enhancing contrast nanoagents, as well as their potential to transition from a proof-of-concept approach to a cancer detection tool in vitro and in vivo.
authors.affiliation: a Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock , Little Rock , AR , USA.
authors.forename: Emilie
authors.identifier: 0000-0001-8956-183X
authors.initials: E
authors.lastname: Darrigues
authors.affiliation: a Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock , Little Rock , AR , USA.
authors.forename: Zeid A
authors.identifier: 0000-0003-4645-5177
authors.initials: ZA
authors.lastname: Nima
authors.affiliation: a Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock , Little Rock , AR , USA.
authors.forename: Waqar
authors.initials: W
authors.lastname: Majeed
authors.affiliation: a Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock , Little Rock , AR , USA.
authors.forename: Kieng Bao
authors.initials: KB
authors.lastname: Vang-Dings
authors.affiliation: a Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock , Little Rock , AR , USA.
authors.forename: Vijayalakshmi
authors.identifier: 0000-0002-8214-3368
authors.initials: V
authors.lastname: Dantuluri
authors.affiliation: b National Institute for Research and Development of Isotopic and Molecular Technologies.
authors.forename: Alexandru R
authors.initials: AR
authors.lastname: Biris
authors.affiliation: c Arkansas Nanomedicine Center , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
authors.forename: Vladimir P
authors.identifier: 0000-0003-4773-0548
authors.initials: VP
authors.lastname: Zharov
authors.affiliation: c Arkansas Nanomedicine Center , University of Arkansas for Medical Sciences , Little Rock , AR , USA.|d Department of Radiation Oncology , Arkansas Nanomedicine Center, University of Arkansas for Medical Sciences , Little Rock , AR , USA.
authors.forename: Robert J
authors.identifier: 0000-0002-3574-2958
authors.initials: RJ
authors.lastname: Griffin
authors.affiliation: a Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock , Little Rock , AR , USA.
authors.forename: Alexandru S
authors.initials: AS
authors.lastname: Biris
mesh_terms: D000818:Animals; D006801:Humans; D053758:Nanoparticles; D037742:Nanotubes, Carbon; D009369:Neoplasms / Q000175:diagnosis*; D013059:Spectrum Analysis, Raman / Q000379:methods*; D020349:Surface Plasmon Resonance / Q000379:methods
chemical_list: D037742:Nanotubes, Carbon
keywords: Cancer; Raman; SERS; carbonaceous; detection; diagnosis; nanotechnology; plasmonic