title: Examining the efficacy of social-psychological interventions for the management of fatigue in end-stage kidney disease (ESKD): a systematic review with meta-analysis.
abstract: Fatigue affects between 42% and 89% of end-stage kidney disease (ESKD) patients, with significant repercussions on quality of life and clinical outcomes. Fatigue management revolves around pharmacotherapy or exercise, which have only modest and short-term improvements. The aim of this systematic review was to investigate whether social-psychological interventions are effective at reducing fatigue in ESKD. Databases were searched to identify randomized controlled trials (RCTs) and quasi-RCTs that determined the effect of social-psychological interventions on fatigue (primary or secondary outcome), in the renal patient population. A meta-analysis was conducted. Sixteen RCTs (N = 1536) were included, predominantly among dialysis patients. Fatigue was a primary outcome in only two studies. The meta-analytic findings showed a significant improvement in fatigue following social-psychological interventions (standardised mean difference, SMD = 0.37, p = .001; 95% CI 0.15 to 0.59, I² = 69.1%, p < .001). There was evidence for greater effectiveness of interventions including stress-management/relaxation techniques, evaluated among fatigued samples meeting diagnostic thresholds, against passive/non-active comparison groups. The studies were generally of poor quality, with high heterogeneity, particularly with the number of sessions ranging from 2 to 96. Development and evaluation of a fatigue-specific social-psychological intervention is warranted in this setting.
authors.affiliation: a Health Psychology Section, Psychology Department , Institute of Psychiatry, Psychology and Neuroscience, King's College London , London , UK.
authors.forename: Federica
authors.initials: F
authors.lastname: Picariello
authors.affiliation: a Health Psychology Section, Psychology Department , Institute of Psychiatry, Psychology and Neuroscience, King's College London , London , UK.
authors.forename: Joanna L
authors.initials: JL
authors.lastname: Hudson
authors.affiliation: a Health Psychology Section, Psychology Department , Institute of Psychiatry, Psychology and Neuroscience, King's College London , London , UK.
authors.forename: Rona
authors.initials: R
authors.lastname: Moss-Morris
authors.affiliation: b Department of Renal Medicine , King's College Hospital , London , UK.
authors.forename: Iain C
authors.initials: IC
authors.lastname: Macdougall
authors.affiliation: a Health Psychology Section, Psychology Department , Institute of Psychiatry, Psychology and Neuroscience, King's College London , London , UK.
authors.forename: Joseph
authors.initials: J
authors.lastname: Chilcot
mesh_terms: D005221:Fatigue / Q000209:etiology / Q000523:psychology* / Q000628:therapy*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000523:psychology / Q000628:therapy*; D011613:Psychotherapy / Q000379:methods*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis / Q000523:psychology
keywords: End-stage kidney disease; fatigue; haemodialysis; intervention; meta-analysis; psychosocial; systematic review