title: Malignant peripheral nerve sheath tumor of the tongue with an unusual pattern of recurrence.
abstract: Malignant peripheral nerve sheath tumor (MPNST) of oral cavity is an extremely uncommon malignancy. Less than 15 cases have been reported since 1973 though none of them describes a distant metastasis. We present a rare case of MPNST of the tongue who presented with features of hypoglossal nerve palsy. Incisional biopsy showed a malignant spindle cell tumor in the sub-epithelial connective tissue. The tumor cells were immune-positive for S-100. He underwent surgery followed by adjuvant chemo-radiation. Later the disease recurred in the form of isolated pelvic bone metastasis. Palliative chemotherapy was offered to him. With this case report we intend to refer to such unusual presentation and pattern of recurrence in a MPNST of tongue.
authors.affiliation: Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Soumyajit
authors.initials: S
authors.lastname: Roy
authors.affiliation: Department of Radiation Oncology, Rajendra Institute of Medical Sciences, Ranchi 834009, India. Electronic address: ajeetgandhi23@gmail.com.
authors.forename: Ajeet Kumar
authors.initials: AK
authors.lastname: Gandhi
authors.affiliation: Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Bharti
authors.initials: B
authors.lastname: Devnani
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Lavleen
authors.initials: L
authors.lastname: Singh
authors.affiliation: Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Bidhu Kalyan
authors.initials: BK
authors.lastname: Mohanti
mesh_terms: D000328:Adult; D006801:Humans; D020437:Hypoglossal Nerve Diseases / Q000188:drug therapy / Q000473:pathology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary; D009442:Neurilemmoma / Q000188:drug therapy / Q000473:pathology*; D010384:Pelvic Bones / Q000473:pathology; D010386:Pelvic Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary; D009418:S100 Proteins; D014062:Tongue Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D009418:S100 Proteins
keywords: Malignant peripheral nerve sheath tumor; Recurrence; Tongue