title: Task and resting-state fMRI studies in first-episode schizophrenia: A systematic review.
abstract: In the last two decades there has been an increase on task and resting-state functional Magnetic Resonance Imaging (fMRI) studies that explore the brain's functional changes in schizophrenia. However, it remains unclear as to whether the brain's functional changes during the resting state are sensitive to the same brain regions during task fMRI. Therefore, we conducted a systematic literature search of task and resting-state fMRI studies that investigated brain pathological changes in first-episode schizophrenia (Fleischhacker et al.). Nineteen studies met the inclusion criteria; seven were resting state fMRI studies with 371 FES patients and 363 healthy controls and twelve were task fMRI studies with 235 FES patients and 291 healthy controls. We found overlapping task and resting-state fMRI abnormalities in the prefrontal regions, including the dorsal lateral prefrontal cortex, the orbital frontal cortex and the temporal lobe, especially in the left superior temporal gyrus (STG). The findings of this systematic review support the frontotemporal hypothesis of schizophrenia, and the disruption in prefrontal and STG might represent the pathophysiology of schizophrenia disorder at a relatively early stage.
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China; The Aga Khan University of East Africa, PO Box 125, Dar es Salaam, Tanzania.
authors.forename: Tumbwene E
authors.initials: TE
authors.lastname: Mwansisya
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors.forename: Aimin
authors.initials: A
authors.lastname: Hu
authors.affiliation: Department of psychology, Gannan Medical University, Ganzhou, Jiangxi 341000, China.
authors.forename: Yihui
authors.initials: Y
authors.lastname: Li
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Wu
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Huang
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Lv
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Li
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Xue
authors.affiliation: Department of Computer Science, University of Warwick, Coventry, United Kingdom; Centre for Computational Systems Biology, Fudan University, Shanghai, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Feng
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China; The State Key Laboratory of Medical Genetics, Central South University, China. Electronic address: zningl@163.com.
authors.forename: Zhening
authors.initials: Z
authors.lastname: Liu
mesh_terms: D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D056344:Executive Function / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D012146:Rest / Q000502:physiology*; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology
keywords: Cognitive task; Functional magnetic resonance imaging; Prefrontal cortex; Resting-state; Temporal lobe