title: TGF-β1Gene -509C/T Polymorphism and Coronary Artery Disease: An Updated Meta-Analysis Involving 11,701 Subjects.
abstract: Background:Thetransforming growth factor-β1 (TGF-β1)gene -509C/T polymorphism has been suggested to be associated with increased coronary artery disease (CAD) risk. However, the individual studies results are still inconsistent.Objective and methods:To investigate the relationship betweenTGF-β1gene -509C/T polymorphism and CAD, a meta-analysis involving 11,701 participants from 8 individual studies was conducted. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals were evaluated by using random or fixed effect models.Results:A significant association betweenTGF-β1gene -509C/T polymorphism and CAD was detected in the total population under allelic (OR: 1.130, 95% CI: 1.060-1.200,P= 0.0001), recessive (OR: 1.390, 95% CI: 1.100-1.750,P= 0.006), dominant (OR: 0.857, 95% CI: 0.785-0.935,P= 2.507 × 10-4), homozygous (OR: 1.258, 95% CI: 1.098-1.442,P= 0.001), heterozygous (OR: 1.147, 95% CI: 1.046-1.257,P= 0.003), and additive genetic models (OR: 1.131, 95% CI: 1.063-1.204,P= 5.442 × 10-5). In the subgroup analysis, there was a significant association between them in Chinese population under all of the genetic models (P< 0.05), except under the heterozygous genetic model (P> 0.05). In the Caucasian subgroup, a significant association between them was also detected under all of the genetic models (P< 0.05), except under the recessive genetic model (P> 0.05).Conclusions:TGF-β1gene -509C/T polymorphism was significantly associated with increased CAD risk. The people with T allele ofTGF-β1gene -509C/T polymorphism might be predisposed to CAD.
authors.affiliation: Department of geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Li
authors.affiliation: Department of geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Zhou
authors.affiliation: Department of geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Gong
authors.affiliation: Department of geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Geng
authors.affiliation: Department of geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Xin-Xing
authors.initials: XX
authors.lastname: Yang
keywords: -509C/T; TGF-β1; coronary artery disease; polymorphism