title: Residual Kidney Function: Implications in the Era of Personalized Medicine.
abstract: The association of residual kidney function (RKF) with improved outcomes in peritoneal dialysis and hemodialysis patients is now widely recognized. RKF provides substantial volume and solute clearance even after dialysis initiation. In particular, RKF provides clearance of nonurea solutes, many of which are potential uremic toxins and not effectively removed by conventional hemodialysis. The presence of RKF provides a distinct advantage to incident dialysis patients and is an opportunity for nephrologists to individualize dialysis treatments tailored to their patients' unique solute, volume, and quality of life needs. The benefits of RKF present the opportunity to personalize the management of uremia.
authors.affiliation: Department of Medicine, The Johns Hopkins University, Baltimore, Maryland.|Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Tariq
authors.initials: T
authors.lastname: Shafi
authors.affiliation: Department of Medicine, The Johns Hopkins University, Baltimore, Maryland.
authors.forename: Surekha
authors.initials: S
authors.lastname: Mullangi
authors.affiliation: Department of Medicine, The Johns Hopkins University, Baltimore, Maryland.
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Toth-Manikowski
authors.affiliation: Department of Medicine, The Johns Hopkins University, Baltimore, Maryland.
authors.forename: Seungyoung
authors.initials: S
authors.lastname: Hwang
authors.affiliation: Division of Nephrology, Department of Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Wieneke M
authors.initials: WM
authors.lastname: Michels
mesh_terms: D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy*; D057285:Precision Medicine / Q000379:methods*; D011379:Prognosis; D006435:Renal Dialysis