title: Crude 4-methylcyclohexanemethanol (MCHM) did not cause skin irritation in humans in 48-h patch test.
abstract: Crude 4-methylcyclohexanemethanol (MCHM) is an industrial chemical used to wash and clean coal. On January 9th, 2014 approximately 10,000 gallons of a mixture containing crude MCHM were released into the Elk River near Charleston, West Virginia, contaminating the local water supply. Following the spill, residents reported numerous health complaints, and sought medical attention for ailments including rashes and itching. The relationship between the complaints and the spill were unknown, as such symptoms are reported frequently in the background. In this study, the primary irritation potential of crude MCHM was evaluated in 206 individuals who underwent 48 hour semi-occluded patch testing. MCHM concentrations assessed in this study were 1, 5, 15, and 100 ppm. No appreciable skin reactions were observed in individuals at any concentration. Three of the five concentrations evaluated were above the highest measured concentration of MCHM in the tap water of residents in West Virginia (3.7 ppm). The results of this study suggest that crude MCHM would not be a dermal irritant for the vast majority, if not all, potentially exposed persons at the concentrations in the water reported after the spill.
authors.affiliation: a Cardno ChemRisk , San Francisco , CA , USA.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Monnot
authors.affiliation: a Cardno ChemRisk , San Francisco , CA , USA.
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Novick
authors.affiliation: a Cardno ChemRisk , San Francisco , CA , USA.
authors.forename: Dennis J
authors.identifier: http://orcid.org/0000-0002-9071-4706
authors.initials: DJ
authors.lastname: Paustenbach
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003510:Cyclohexanes / Q000633:toxicity*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012867:Skin / Q000187:drug effects*; D055815:Young Adult
chemical_list: D003510:Cyclohexanes; C000607184:4-methylcyclohexanemethanol
keywords: 4-methylcyclohexanemethanol; Crude MCHM; Elk River spill; West Virginia Chemical Spill