title: Long noncoding RNA CCAT2 can predict metastasis and a poor prognosis: A meta-analysis.
abstract: BACKGROUND
  Colon cancer associated transcript 2 (CCAT2), a novel long non-coding RNA (lncRNA), plays a key role in tumorigenesis. This meta-analysis systematically summarizes the relationship between CCAT2 and cancers.
  
  
  METHODS
  A comprehensive, computerized literature search was conducted in PubMed, Cochrane library, Chinese National Knowledge Infrastructure, and Chinese Wan Fang database. Odds ratios (ORs), hazard ratios (HRs) and their 95% confidence interval (95% CI) were calculated to assess the effect size. A total of 9 studies were enrolled in this meta-analysis, which was performed by Revman5.3 software and Stata12.0.
  
  
  RESULTS
  Our meta-analysis indicates that patients with elevated expression of CCAT2 are prone to developing distant metastasis (DM) (OR=12.42; 95% CI=5.77-26.74; P < 0.00001), which is associated with a tendency for lymph nodes metastasis (LNM) (OR=3.60 95% CI=1.65-7.87, P=0.001). Further analyses reveal that patients with high CCAT2 expression have poorer overall survival (OS) (HR=1.53, 95% CI=1.15-2.02, P=0.003, random-effects) and progression-free survival (PFS) (HR=2.88, 95% CI=1.81-4.56, P < 0.00001, fixed-effects).
  
  
  CONCLUSIONS
  Therefore, CCAT2 may be a potential novel biomarker for indicating clinical outcomes of human cancers.
authors.affiliation: Department of Clinical Laboratory, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, 29 Shuangta Road, Taiyuan 030012, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Jing
authors.affiliation: Department of Clinical Laboratory, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, 29 Shuangta Road, Taiyuan 030012, China.
authors.forename: Hongping
authors.initials: H
authors.lastname: Liang
authors.affiliation: Department of Reproductive Medicine Center, Children's Hospital of Shanxi and Women, Health Center of Shanxi, Taiyuan, Shanxi 030000, China; Department of Clinical Laboratory, The Central Hospital of Linfen, Affiliate of Shanxi Medical University, 101 Pingyang North Street, Linfen 04100, China. Electronic address: cuixiangrong094030@163.com.
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Cui
authors.affiliation: Department of Clinical Laboratory, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, 29 Shuangta Road, Taiyuan 030012, China.
authors.forename: Chongyang
authors.initials: C
authors.lastname: Han
authors.affiliation: Department of Clinical Laboratory, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, 29 Shuangta Road, Taiyuan 030012, China.
authors.forename: Chonghua
authors.initials: C
authors.lastname: Hao
authors.affiliation: Department of neurosurgery, Shanxi Provincial Tumor Hospital, 3 Staff Village, Taiuan, Shanxi 030000, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Huo
mesh_terms: D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology*; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding; C000609264:long non-coding RNA CCAT2, human
keywords: CCAT2; Carcinoma; Long non-coding RNA; Meta-analysis