title: Establishment and function of tissue-resident innate lymphoid cells in the skin.
abstract: Innate lymphoid cells (ILCs) are a newly classified family of immune cells of the lymphoid lineage. While they could be found in both lymphoid organs and non-lymphoid tissues, ILCs are preferentially enriched in barrier tissues such as the skin, intestine, and lung where they could play important roles in maintenance of tissue integrity and function and protection against assaults of foreign agents. On the other hand, dysregulated activation of ILCs could contribute to tissue inflammatory diseases. In spite of recent progress towards understanding roles of ILCs in the health and disease, mechanisms regulating specific establishment, activation, and function of ILCs in barrier tissues are still poorly understood. We herein review the up-to-date understanding of tissue-specific relevance of ILCs. Particularly we will focus on resident ILCs of the skin, the outmost barrier tissue critical in protection against various foreign hazardous agents and maintenance of thermal and water balance. In addition, we will discuss remaining outstanding questions yet to be addressed.
authors.affiliation: Centre for Molecular Immunology and Infectious Diseases and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.|Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Houston, TX, 77054, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.affiliation: Centre for Molecular Immunology and Infectious Diseases and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
authors.forename: Luming
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Centre for Molecular Immunology and Infectious Diseases and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.affiliation: Centre for Molecular Immunology and Infectious Diseases and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, 16802, USA. nux1@psu.edu.
authors.forename: Na
authors.identifier: 0000-0003-4405-6818
authors.initials: N
authors.lastname: Xiong
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007249:Inflammation / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D012867:Skin / Q000276:immunology*
keywords: chemokine receptor; homeostasis; inflammation; innate lymphoid cells; migration; skin