title: Calcium-activated chloride channels: a new target to control the spiking pattern of neurons.
abstract: The nature of encoded information in neural circuits is determined by neuronal firing patterns and frequencies. This paper discusses the molecular identity and cellular mechanisms of spike-frequency adaptation in the central nervous system (CNS). Spike-frequency adaptation in thalamocortical (TC) and CA1 hippocampal neurons is mediated by the Ca2＋-activated Cl-channel (CACC) anoctamin-2 (ANO2). Knockdown of ANO2 in these neurons results in increased number of spikes, in conjunction with significantly reduced spike-frequency adaptation. No study has so far demonstrated that CACCs mediate afterhyperpolarization currents, which result in the modulation of neuronal spike patterns in the CNS. Our study therefore proposes a novel role for ANO2 in spike-frequency adaptation and transmission of information in the brain. [BMB Reports 2017; 50(3): 109-110].
authors.affiliation: Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.
authors.forename: Go Eun
authors.initials: GE
authors.lastname: Ha
authors.affiliation: Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.
authors.forename: Eunji
authors.initials: E
authors.lastname: Cheong
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D000075368:Anoctamins; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology; D018118:Chloride Channels / Q000378:metabolism*; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism*
chemical_list: C521849:ANO2 protein, human; D000075368:Anoctamins; D018118:Chloride Channels; D008565:Membrane Proteins; D002118:Calcium