title: Impact of sarcopenia in the management of urological cancer patients.
abstract: Sarcopenia, the degenerative and systemic loss of skeletal muscle mass, develops as a consequence of the progression of cancer cachexia. Recent studies suggest that sarcopenia may be used as a biomarker in the management of patients with several cancers. Areas covered: In this article, the authors review 1) the methods to simply and optimally evaluate and define sarcopenia using computed tomography images in daily clinical practice and 2) the impact of sarcopenia in the management of urological cancers, specifically focusing on the usefulness in predicting treatment-related complications and prognosis. The authors also discuss the prognostic importance of changes in skeletal muscle mass in the course of treatment and the potential roles of nutritional support and exercise to prevent progression of sarcopenia. Expert commentary: Sarcopenia is associated with treatment-related complications and unfavorable prognosis in urological cancer patients. Nutritional support and exercise might be helpful in improving sarcopenia. The impact of these interventions on clinical outcomes would be elucidated by ongoing or future clinical studies.
authors.affiliation: a Department of Urology , Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Tokyo , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukushima
authors.affiliation: a Department of Urology , Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Tokyo , Japan.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Koga
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002100:Cachexia / Q000209:etiology*; D018450:Disease Progression; D005081:Exercise Therapy / Q000379:methods; D006801:Humans; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000473:pathology; D018529:Nutritional Support / Q000379:methods; D011379:Prognosis; D055948:Sarcopenia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D014057:Tomography, X-Ray Computed / Q000379:methods; D014571:Urologic Neoplasms / Q000473:pathology* / Q000628:therapy
chemical_list: D015415:Biomarkers
keywords: Sarcopenia; biomarker; prognosis; skeletal muscle index; urological cancer