title: Long-term Follow-up of Patients With Severe Aortic Stenosis Treated With a Self-expanding Prosthesis.
abstract: OBJECTIVE
  Transcatheter aortic valve implantation (TAVI) is a safe and effective alternative to surgical treatment in patients with severe aortic stenosis (AS) and those who are inoperable or at high surgical risk. The primary objective of this study was to evaluate the long-term survival of consecutive patients with severe AS treated with TAVI.
  
  
  METHODS
  Observational, multicenter, prospective, follow-up study of consecutive patients with severe symptomatic AS treated by TAVI in 3 high-volume hospitals in Spain.
  
  
  RESULTS
  We recruited 108 patients, treated with a self-expanding CoreValve prosthesis. The mean age at implantation was 78.6 ± 6.7 years, 49 (45.4%) were male and the mean logistic EuroSCORE was 16% ± 13.9%. The median follow-up was 6.1 years (2232 days). Survival rates at the end of years 1, 2, 3, 4, 5, and 6 were 84.3% (92.6% after hospitalization), 77.8%, 72.2%, 66.7%, 58.3%, and 52.8%. During follow-up, 71 patients (65.7%) died, 18 (25.3%) due to cardiac causes. Most (82.5%) survivors were in New York Heart Association class I or II. Six patients (5.5%) developed prosthetic valve dysfunction.
  
  
  CONCLUSIONS
  Long-term survival in AS patients after TAVI is acceptable. The main causes of death are cardiovascular in the first year and noncardiac causes in subsequent years. Valve function is maintained over time.
authors.affiliation: Área del Corazón, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Avanzas
authors.affiliation: Área del Corazón, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
authors.forename: Isaac
authors.initials: I
authors.lastname: Pascual
authors.affiliation: Servicio de Cardiología, Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain.
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Muñoz-García
authors.affiliation: Servicio de Cardiología, Hospital Universitario Reina Sofía, Córdoba, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Segura
authors.affiliation: Servicio de Cardiología, Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain.
authors.forename: Juan H
authors.initials: JH
authors.lastname: Alonso-Briales
authors.affiliation: Servicio de Cardiología, Hospital Universitario Reina Sofía, Córdoba, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Suárez de Lezo
authors.affiliation: Servicio de Cardiología, Hospital Universitario Reina Sofía, Córdoba, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Pan
authors.affiliation: Servicio de Cardiología, Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain.
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Jiménez-Navarro
authors.affiliation: Servicio de Cardiología, Hospital Universitario Reina Sofía, Córdoba, Spain.
authors.forename: José
authors.initials: J
authors.lastname: López-Aguilera
authors.affiliation: Servicio de Cardiología, Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain. Electronic address: jmhg@secardiologia.es.
authors.forename: José M
authors.initials: JM
authors.lastname: Hernández-García
authors.affiliation: Área del Corazón, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
authors.forename: César
authors.initials: C
authors.lastname: Morís
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011474:Prosthesis Design; D011475:Prosthesis Failure; D013030:Spain / Q000453:epidemiology; D065467:Transcatheter Aortic Valve Replacement / Q000295:instrumentation / Q000379:methods* / Q000401:mortality; D016896:Treatment Outcome
keywords: Aortic stenosis; Estenosis aórtica; Prognosis; Pronóstico; TAVI; Tratamiento; Treatment