title: Chemical profiling and biological properties of Neolitsea kedahense Gamble essential oils.
abstract: Hydrodistillation of the fresh stem and leaf of Neolitsea kedahense Gamble, collected from Gunung Jerai, Malaysia followed by the GC-FID and GC-MS analysis revealed the detection of a total of 47 constituents of which 28 (86.4%) from the stem and 31 (96.4%) constituents from the leaf. δ-Cadinene (17.4%), 1-epi-cubenol (11.8%), cyperotundone (9.0%), cis-cadin-4-en-7-ol (7.7%), τ-cadinol (7.1%) and α-cadinol (7.1%) were the principle constituents in the stem oil, whereas β-caryophyllene (18.9%), bicyclogermacrene (18.6%) and trans-muurola-4(14),5-diene (9.8%) were the major constituents in the leaf oil. Among the identified constituents, three constituents namely 7-epi-α-selinene, junenol and cis-cadin-4-en-7-ol have not been found previously from Neolitsea oils. The stem and leaf oils were screened for their α-glucosidase inhibitory and antibacterial activities. Both oils displayed potential α-glucosidase inhibitory activity, while the stem oil possessed weak antibacterial activity against Bacillus subtilis.
authors.affiliation: a Faculty of Science, Department of Chemistry , Universiti Teknologi Malaysia , Skudai , Malaysia.|b Faculty of Applied Science , Universiti Teknologi MARA Cawangan Negeri Sembilan , Kuala Pilah , Malaysia.
authors.forename: Nor Akmalazura
authors.initials: NA
authors.lastname: Jani
authors.affiliation: a Faculty of Science, Department of Chemistry , Universiti Teknologi Malaysia , Skudai , Malaysia.
authors.forename: Hasnah Mohd
authors.initials: HM
authors.lastname: Sirat
authors.affiliation: a Faculty of Science, Department of Chemistry , Universiti Teknologi Malaysia , Skudai , Malaysia.
authors.forename: Farediah
authors.initials: F
authors.lastname: Ahmad
authors.affiliation: c Herbal Product Development Programme, Natural Products Division , Forest Research Institute Malaysia (FRIM) , Kuala Lumpur , Malaysia.
authors.forename: Nor Azah
authors.initials: NA
authors.lastname: Mohamad Ali
authors.affiliation: c Herbal Product Development Programme, Natural Products Division , Forest Research Institute Malaysia (FRIM) , Kuala Lumpur , Malaysia.
authors.forename: Mailina
authors.initials: M
authors.lastname: Jamil
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D019770:Lauraceae / Q000737:chemistry*; D008296:Malaysia; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000032:analysis / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000032:analysis / Q000494:pharmacology; D013729:Terpenes / Q000032:analysis / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D065089:Glycoside Hydrolase Inhibitors; D009822:Oils, Volatile; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D013729:Terpenes; C445364:cadinol; C541832:cyperotundone; C000607799:delta-cadinene; C024714:caryophyllene
keywords: Neolitsea kedahense Gamble; antibacterial; α-glucosidase inhibitory