title: A new sesquiterpene lactone from fungus Eutypella sp. D-1.
abstract: We isolated and identified a new sesquiterpene lactone which we named eut-Guaiane sesquiterpene (1), along with four cytochalasins from the fungus Eutypella sp. derived from the soil of high latitude of Arctic. The new structure was determined by spectroscopic studies such as 1D and 2D NMR and MS analyses, while the known compounds were identified by comparison of the NMR data with those in literatures. New compound 1 exhibited strong antibacterial activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus. Besides, it showed a little cytotoxicity against SGC7901 cell line.
authors.affiliation: a Marine Biopharmaceutical Institute , Second Military Medical University , Shanghai , P.R. China.|b Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences , Second Military Medical University , Shanghai , P.R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: a Marine Biopharmaceutical Institute , Second Military Medical University , Shanghai , P.R. China.|b Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences , Second Military Medical University , Shanghai , P.R. China.
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Zhang
authors.affiliation: b Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences , Second Military Medical University , Shanghai , P.R. China.
authors.forename: Jian-Peng
authors.initials: JP
authors.lastname: Zhang
authors.affiliation: a Marine Biopharmaceutical Institute , Second Military Medical University , Shanghai , P.R. China.|b Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences , Second Military Medical University , Shanghai , P.R. China.
authors.forename: Hao-Bing
authors.initials: HB
authors.lastname: Yu
authors.affiliation: a Marine Biopharmaceutical Institute , Second Military Medical University , Shanghai , P.R. China.|b Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences , Second Military Medical University , Shanghai , P.R. China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Liu
authors.affiliation: a Marine Biopharmaceutical Institute , Second Military Medical University , Shanghai , P.R. China.|b Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences , Second Military Medical University , Shanghai , P.R. China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Lu
authors.affiliation: a Marine Biopharmaceutical Institute , Second Military Medical University , Shanghai , P.R. China.|b Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences , Second Military Medical University , Shanghai , P.R. China.
authors.forename: Bing-Hua
authors.initials: BH
authors.lastname: Jiao
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D001203:Ascomycota / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007783:Lactones / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D045789:Sesquiterpenes, Guaiane; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D007783:Lactones; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C421026:guaiane
keywords: Antibacterial activity; Eutypella sp; sesquiterpene lactone