title: Phytochemicals of Pogostemon Cablin (Blanco) Benth. aqueous extract: Their xanthine oxidase inhibitory activities.
abstract: Bioassay-guided fractionation of the aerial part of P. cablin revealed that fraction A3 of the water extract exhibited significant xanthine oxidase inhibitory activities (IC50=85.42±1.71μg/mL), which further led to the isolation of ten more bioactive compounds, including two new compounds (1 and 2). The structures of compounds 1 and 2 were elucidated by extensive spectral analysis. It is revealed that flavonoids and phenolic compounds were found to be responsible for the xanthine oxidase inhibitory activities of P. cablin. Especially, rosmarinic acid was found to be with potent XO inhibitory activity (IC50=8.53±0.91μg/mL).
authors.affiliation: College of Pharmacy, Central South University, Changsha 410013, PR China; College of Pharmacy, Xiangnan University, Chenzhou 423043, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: College of Pharmacy, Central South University, Changsha 410013, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Deng
authors.affiliation: College of Pharmacy, Central South University, Changsha 410013, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.affiliation: College of Pharmacy, Central South University, Changsha 410013, PR China.
authors.forename: Guangyao
authors.initials: G
authors.lastname: Zeng
authors.affiliation: College of Pharmacy, Central South University, Changsha 410013, PR China.
authors.forename: Xu
authors.initials: X
authors.lastname: Deng
authors.affiliation: College of Pharmacy, Central South University, Changsha 410013, PR China. Electronic address: zhouyingjun@csu.edu.cn.
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D064209:Phytochemicals / Q000737:chemistry / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D000070177:Pogostemon / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D005419:Flavonoids; D010636:Phenols; D064209:Phytochemicals; D010936:Plant Extracts; D014969:Xanthine Oxidase
keywords: Phytochemicals; Pogostemon cablin (Blanco) Benth.; Water extract; Xanthine oxidase inhibition