title: Immunohistochemical Comparison of the Expression of CD34 and CD105 in Odontogenic Keratocyst and Dentigerous Cyst.
abstract: BACKGROUND
  Odontogenic keratocyst (OKC) is a developmental odontogenic cyst with specific histopathological features, high recurrence rate, and aggressive clinical behavior. Angiogenesis might be considered as an important factor for the growth, expansion, and distribution of this lesion.
  
  
  OBJECTIVE
  The aim of the present study was to determine the mean vascular densities (MVD) of OKCs and dentigerous cysts to evaluate their relationship with the biologic behavior of these lesions.
  
  
  METHODS
  In this cross-sectional analytical study, angiogenesis was assessed in OKC and dentigerous cyst by measuring the MVD. Immunohistochemistry was carried out using CD34 and CD105. The results were analyzed with independent samples t-test. The data were analyzed, settingpvalue at 0.05.
  
  
  RESULTS
  The MVDs with the use of CD34 and CD105 markers were significantly higher in OKC compared to dentigerous cyst (p< 0.05). In addition, MVDs obtained by CD105 in dentigerous cysts and OKC were significantly less than those based on CD34 (p< 0.05).
  
  
  CONCLUSIONS
  Based on the results of the present study, it can be suggested that angiogenesis might be one of the possible mechanisms involved in higher aggressive biologic behavior and greater recurrence rate of OKC compared to dentigerous cysts.
authors.affiliation: Dental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Shokoofeh
authors.initials: S
authors.lastname: Jamshidi
authors.affiliation: Dental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Massoumeh
authors.initials: M
authors.lastname: Zargaran
authors.affiliation: Dept. of Biostatistics, Hamadan University of Medical Sciences & Health Services, Hamadan, Iran.
authors.forename: Ghodratollah
authors.initials: G
authors.lastname: Roshanaei
authors.affiliation: Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Hadadi
authors.affiliation: Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Dehghani Nazhvani
keywords:  CD34 ;  Dentigerous cyst ;  Immunohistochemistry ;  Odontogenic keratocyst; CD105 