title: Controlling the morphology of copolymeric vectors for next generation nanomedicine.
abstract: Amidst the wealth of information that the past few decades of nanomedical research has given us there is one design principle that has emerged as being key for the success of delivery vectors: particle morphology. This review seeks to unpack the various facets of particle morphology that are important for effective integration in vivo. In order to understand the contribution of morphology towards the biophysical function of nanovectors it is important to consider the historical development of such systems and how their physicochemical characteristics are selected. Ultimately, the purpose of this review is to give a clear perspective for the development of future nanovectors and how an integrated approach to their design, with particular focus upon their morphological features (size, shape, stimuli-responsiveness and surface chemistry), is vital for their performance in vitro and in vivo.
authors.affiliation: Eindhoven University of Technology, P.O. Box 513 (STO 3.31), 5600 MB Eindhoven, The Netherlands. Electronic address: d.s.williams@tue.nl.
authors.forename: David S
authors.initials: DS
authors.lastname: Williams
authors.affiliation: Eindhoven University of Technology, P.O. Box 513 (STO 3.31), 5600 MB Eindhoven, The Netherlands.
authors.forename: Imke A B
authors.initials: IAB
authors.lastname: Pijpers
authors.affiliation: Eindhoven University of Technology, P.O. Box 513 (STO 3.31), 5600 MB Eindhoven, The Netherlands.
authors.forename: Roxane
authors.initials: R
authors.lastname: Ridolfo
authors.affiliation: Eindhoven University of Technology, P.O. Box 513 (STO 3.31), 5600 MB Eindhoven, The Netherlands. Electronic address: j.c.m.v.hest@tue.nl.
authors.forename: Jan C M
authors.initials: JCM
authors.lastname: van Hest
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D015195:Drug Design; D050997:Nanomedicine; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D011108:Polymers
keywords: Drug delivery; Nanomedicine; Nanoparticles; Nanovectors