title: Development of a Novel Markov Chain Model for the Prediction of Head and Neck Squamous Cell Carcinoma Dissemination.
abstract: Prediction of microscopic tumor spread to regional lymph nodes can assist in radiation planning for cancer treatment. However, it is still challenging to predict tumor spread. In this paper, we present a unique approach to modeling how tumor cells disseminate to form regional metastases. This involves leveraging well established knowledge resources and commonly held notions of how cancer spreads. Using patient data, we utilized our approach to create a model of metastasis for the subset of head and neck squamous cell carcinoma that arises in the mucosa of the lateral tongue. The model was created using a training set extracted from the clinical records of 50 patients with tumors of this type who presented to the University of Washington head and tumor board over a three and half year period. The test sets consist of four case series drawn from the literature.
authors.affiliation: Department of Biomedical Informatics and Medical Education.
authors.forename: Hyunggu
authors.initials: H
authors.lastname: Jung
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery.
authors.forename: Anthony
authors.initials: A
authors.lastname: Law
authors.affiliation: Medical Scientist Training Program.
authors.forename: Eli
authors.initials: E
authors.lastname: Grunblatt
authors.affiliation: Department of Biomedical Informatics and Medical Education.
authors.forename: Lucy L
authors.initials: LL
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology.
authors.forename: Aaron
authors.initials: A
authors.lastname: Kusano
authors.affiliation: Department of Biological Structure University of Washington, Seattle, WA.
authors.forename: Jose L V
authors.initials: JL
authors.lastname: Mejino
authors.affiliation: Department of Biomedical Informatics and Medical Education; Department of Otolaryngology-Head and Neck Surgery.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Whipple
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000556:secondary; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis / Q000503:physiopathology*; D008297:Male; D008390:Markov Chains; D008875:Middle Aged; D008954:Models, Biological