title: Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy.
abstract: BACKGROUND
  Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development.
  
  
  METHODS
  Three-hundred and four children (median age 13.4 months at entry) with food allergy symptoms and/or atopic dermatitis without asthma at inclusion were analysed for IgE antibodies against food-, indoor- and outdoor-allergens and pet allergen components and correlated to the individuals' outcome on asthma inception.
  
  
  RESULTS
  At 2 years of follow-up, physician-diagnosed asthma was 19.7% (n = 49) and asthma diagnosed any time was 24% (n = 67). History of persistent cough and asthma of father, combination of milk- and wheat-allergy symptoms and dual sensitization to house dust mite and Japanese cedar were independent risk factors for asthma. Sensitization to dog was the most prevalent inhalant allergen at entry. Asthma children had a higher proportion of sensitization to dog, cat and horse allergens at entry compared with non-asthma children. Being sensitized to both food, house dust mite and pet allergens was strongly associated with asthma (p = 0.0006). Component resolved diagnosis for dog and cat allergens showed that IgE antibodies to Can f 1 and Fel d 1 was common even at very young age.
  
  
  CONCLUSIONS
  Early sensitization to inhalant allergens increases the risk of developing asthma as well as having milk and wheat allergy symptoms. Sensitization to dog, was common at an early age despite dog ownership. Sensitization to secretoglobin and lipocalins and less to serum albumins explained the pet sensitization.
authors.affiliation: Allergy Center and Department of Clinical Research, Mie National Hospital, IDD, Tsu, Mie Japan.
authors.forename: Mizuho
authors.initials: M
authors.lastname: Nagao
authors.affiliation: Thermo Fisher Scientific, Uppsala, Sweden.|Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
authors.forename: Magnus P
authors.initials: MP
authors.lastname: Borres
authors.affiliation: Allergy Center and Department of Clinical Research, Mie National Hospital, IDD, Tsu, Mie Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Sugimoto
authors.affiliation: Thermo Fisher Scientific, Uppsala, Sweden.
authors.forename: Carl Johan
authors.initials: CJ
authors.lastname: Petersson
authors.affiliation: Thermo Fisher Scientific, Uppsala, Tokyo Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nakayama
authors.affiliation: Department of Pediatrics, Mie National Hospital, Tsu, Mie Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Kuwabara
authors.affiliation: Department of Otorhinolaryngology, Mie National Hospital, Tsu, Mie Japan.
authors.forename: Sawako
authors.initials: S
authors.lastname: Masuda
authors.affiliation: Thermo Fisher Scientific, Uppsala, Sweden.
authors.forename: Patrik
authors.initials: P
authors.lastname: Dykiel
authors.affiliation: Allergy Center and Department of Clinical Research, Mie National Hospital, IDD, Tsu, Mie Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Fujisawa
keywords: Allergy; Asthma; Children; Component resolved diagnosis; Food allergy; Lipocalin; Molecular allergy diagnostics; Pet allergen components; Secretoglobin; Sensitization