title: Regulatory feedback from nascent RNA to chromatin and transcription.
abstract: Transcription and chromatin function are regulated by proteins that bind to DNA, nucleosomes or RNA polymerase II, with specific non-coding RNAs (ncRNAs) functioning to modulate their recruitment or activity. Unlike ncRNAs, nascent pre-mRNA was considered to be primarily a passive player in these processes. In this Opinion article, we describe recently identified interactions between nascent pre-mRNAs and regulatory proteins, highlight commonalities between the functions of nascent pre-mRNA and nascent ncRNA, and propose that both types of RNA have an active role in transcription and chromatin regulation.
authors.affiliation: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.
authors.forename: Lenka
authors.initials: L
authors.lastname: Skalska
authors.affiliation: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.
authors.forename: Manuel
authors.initials: M
authors.lastname: Beltran-Nebot
authors.affiliation: Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK; and The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
authors.forename: Jernej
authors.initials: J
authors.lastname: Ule
authors.affiliation: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Jenner
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D012326:RNA Splicing; D012097:Repressor Proteins / Q000378:metabolism; D061805:Transcription Elongation, Genetic; D014157:Transcription Factors; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D012097:Repressor Proteins; D014157:Transcription Factors