title: Rhodium(III)-Catalyzed C6-Selective Arylation of 2-Pyridones and Related Heterocycles Using Quinone Diazides: Syntheses of Heteroarylated Phenols.
abstract: An efficient, direct C6-arylation of 2-pyridones has been successfully accomplished with quinone diazides under Rh(III)-catalyzed redox-neutral conditions. The optimized method is simple, mild, and highly regioselective with a broad substrate scope. The strict regioselectivity is guided by the pyridyl substituent attached to the nitrogen of the pyridone ring. As the directing 2-pyridyl group can easily be removed at any suitable stage after functionalization, the method provides a facile access to complex heteroarylated phenol moieties by wide-ranging heterocyclic scaffolds.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur , Kharagpur 721302, India.
authors.forename: Debapratim
authors.initials: D
authors.lastname: Das
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur , Kharagpur 721302, India.
authors.forename: Puja
authors.initials: P
authors.lastname: Poddar
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur , Kharagpur 721302, India.
authors.forename: Saurabh
authors.identifier: 0000-0002-5413-2135
authors.initials: S
authors.lastname: Maity
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur , Kharagpur 721302, India.
authors.forename: Rajarshi
authors.identifier: 0000-0002-7925-6601
authors.initials: R
authors.lastname: Samanta