title: Design, synthesis, and in vitro antituberculosis activity of benzo[6,7]cyclohepta[1,2-b]pyridine-1,3,4-oxadiazole derivatives.
abstract: A new antitubercular agents, benzo[6,7]cyclohepta[1,2-b]pyridine-1,3,4- oxadiazole hybrids (6a-o), have been designed and synthesized involving oxidative cyclization of hydrazones by use of di(acetoxy)iodobenzene, characterized by IR,1H NMR,13C NMR, and HRMS, and further confirmed by X-ray analysis. All the newly synthesized compounds 4a-o evaluated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC27294). Among the compounds tested, the compounds 4o (MIC: 1.56 μg/ml) and 4l, 4m (MIC: 3.125 μg/ml) are promising lead analogues and have shown lower cytotoxicity.
authors.affiliation: Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.
authors.forename: Yasodakrishna
authors.initials: Y
authors.lastname: Sajja
authors.affiliation: Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.
authors.forename: Sowmya
authors.initials: S
authors.lastname: Vanguru
authors.affiliation: Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.
authors.forename: Hanmanth Reddy
authors.initials: HR
authors.lastname: Vulupala
authors.affiliation: Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.
authors.forename: Lingaiah
authors.identifier: http://orcid.org/0000-0001-5881-7054
authors.initials: L
authors.lastname: Nagarapu
authors.affiliation: Medicinal Chemistry and Antimycobacterial Research Laboratory, Pharmacy Group, Birla Institute of Technology and Science-Pilani, Hyderabad, Telangana, India.
authors.forename: Yogeswari
authors.initials: Y
authors.lastname: Perumal
authors.affiliation: Medicinal Chemistry and Antimycobacterial Research Laboratory, Pharmacy Group, Birla Institute of Technology and Science-Pilani, Hyderabad, Telangana, India.
authors.forename: Dharmarajan
authors.initials: D
authors.lastname: Sriram
authors.affiliation: Centre for X-Ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.
authors.forename: Jagadeesh Babu
authors.initials: JB
authors.lastname: Nanubolu
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D010069:Oxadiazoles; D011725:Pyridines; C583463:1,3,4-oxadiazole
keywords: 
  Mycobacterium tuberculosis
  ; 1,3,4-oxadiazoles; benzo[6,7]cyclohepta[1,2-b]pyridine; cytotoxicity; di(acetoxy)iodobenzene