title: The role and clinical implications of the endosteal niche and osteoblasts in regulating leukemia.
abstract: Osteoblasts are one among the critical components of the endosteal bone marrow (BM) niche. In addition to hematopoietic stem cell fate, their role in leukemogenesis as well as metastasis of a variety of cancers has been demonstrated in various studies. In this regard, endosteal niche can have a dual role as an initiator and protective role against leukemia. Knowledge of growth factors, chemokines and cytokines secreted by osteoblasts as well as their interaction with signaling pathways inform our understanding of the development, prognosis, recurrence and treatment of malignant BM diseases. Clinical progress in targeting the endosteal niche is also discussed.
authors.affiliation: Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Azizidoost
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: V
authors.initials: V
authors.lastname: Vijay
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Cogle
authors.affiliation: Health Research Institute, Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 61357-15794, Iran.
authors.forename: E
authors.initials: E
authors.lastname: Khodadi
authors.affiliation: Health Research Institute, Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 61357-15794, Iran. najmaldinsaki@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Saki
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D010006:Osteoblasts / Q000473:pathology*; D055153:Stem Cell Niche / Q000502:physiology*
keywords: Chemokine; Endosteal niche; Osteoblast; Quiescence; Therapy