title: Pru p 3, a marker allergen for lipid transfer protein sensitization also in Central Europe.
abstract: In the Mediterranean area, lipid transfer proteins (LTPs) are important causes of plant-food allergies often associated with severe allergic reactions. There, peach LTP (Pru p 3) seems to be the primary sensitizer, whereas in Central Europe, little is known about the importance of LTP sensitization. In this region, allergen extract-based diagnosis is often complicated by co-sensitization to Bet v 1, the major birch pollen allergen, its cross-reactive food allergens, and profilins. We investigated the role of LTP sensitization in Central European patients displaying strong allergic reactions to plant-derived food. Analysis of IgE reactivity revealed that ten of thirteen patients were sensitized to Pru p 3, nine to Bet v 1, and two to profilin. Our results showed that LTP sensitization represents a risk factor for severe allergic symptoms in Central Europe. Furthermore, the strong IgE reactivity detected in immunoblots of plant-food extracts indicated that Pru p 3 can be used as a marker allergen for LTP sensitization also in Central European patients.
authors.affiliation: Comparative Immunology and Oncology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
authors.forename: N
authors.initials: N
authors.lastname: Mothes-Luksch
authors.affiliation: Molecular Biotechnology Section, FH Campus Wien, University of Applied Sciences, Campus Vienna Biocenter, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Raith
authors.affiliation: Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, Vienna, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Stingl
authors.affiliation: Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Focke-Tejkl
authors.affiliation: VetCore Facility for Research, University of Veterinary Medicine Vienna, Vienna, Austria.
authors.forename: E
authors.initials: E
authors.lastname: Razzazi-Fazeli
authors.affiliation: Vienna Challenge Chamber, Vienna, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Zieglmayer
authors.affiliation: FAZ - Floridsdorf Allergy Center, Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Wöhrl
authors.affiliation: Molecular Biotechnology Section, FH Campus Wien, University of Applied Sciences, Campus Vienna Biocenter, Vienna, Austria.
authors.forename: I
authors.identifier: http://orcid.org/0000-0002-9164-1721
authors.initials: I
authors.lastname: Swoboda
mesh_terms: D052179:Antigens, Plant / Q000032:analysis / Q000276:immunology*; D015415:Biomarkers / Q000032:analysis; D002352:Carrier Proteins / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology; D005060:Europe; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E; D010940:Plant Proteins / Q000032:analysis* / Q000276:immunology; D051304:Profilins / Q000276:immunology
chemical_list: D052179:Antigens, Plant; D015415:Biomarkers; D002352:Carrier Proteins; D010940:Plant Proteins; D051304:Profilins; C463181:Pru p 3 allergen; C030363:lipid transfer protein; D007073:Immunoglobulin E
keywords: Pru p 3; component resolved diagnosis; food allergy; immunologic tests; lipid transfer protein