title: Gender differences in the association betweenHTR2Cgene variants and suicidal behavior in a Mexican population: a case-control study.
abstract: BACKGROUND
  The aim of this case-control study was to explore the association by gender between theHTR2Cgene variants and suicidal behavior in a Mexican population.
  
  
  METHODS
  A total of 183 suicide attempters and 208 healthy volunteers were included in this study. We genotyped five polymorphisms of HTR2C (rs547536, rs2192372, rs4272555, rs6318, and rs2428707), then measured the association by genotype, allele, and haplotype.
  
  
  RESULTS
  In the female group, we found an association between two polymorphisms of the HTR2C (rs4272555 and rs2428707) and suicide attempts. The C allele of the single-nucleotide polymorphism (SNP) rs4272555 was associated with a decreased risk of suicide attempt (P=0.01, odds ratio =0.26, 95% confidence interval: 0.09-0.79), whereas the G allele of the SNP rs2428707 was associated with an increased risk of suicide attempt (P=0.01, odds ratio =3.68, 95% confidence interval: 1.24-10.90). No significant association was observed between the other polymorphisms studied (rs547536, rs2192372, rs6318) or haplotypes with suicide attempts.
  
  
  CONCLUSIONS
  These findings suggest a possible risk factor of theHTR2Cgene in the pathology of suicidal behavior in Mexican population. More studies are necessary to confirm this association.
authors.affiliation: División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Molina-Guzman
authors.affiliation: División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez.
authors.forename: Thelma Beatriz
authors.initials: TB
authors.lastname: González-Castro
authors.affiliation: División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez.
authors.forename: Yazmín
authors.initials: Y
authors.lastname: Hernández Díaz
authors.affiliation: División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, México.
authors.forename: Carlos Alfonso
authors.initials: CA
authors.lastname: Tovilla-Zárate
authors.affiliation: División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, México.
authors.forename: Isela E
authors.initials: IE
authors.lastname: Juárez-Rojop
authors.affiliation: División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, México.
authors.forename: Crystell Guadalupe
authors.initials: CG
authors.lastname: Guzmán-Priego
authors.affiliation: Instituto Nacional de Medicina Genómica (INMEGEN), Servicios de Atención Psiquiátrica (SAP), Secretaría de Salud, Ciudad de México, México.
authors.forename: Alma
authors.initials: A
authors.lastname: Genis
authors.affiliation: Hospital General de Comalcalco, Secretaria de Salud, Comalcalco, Tabasco, México.
authors.forename: Sherezada
authors.initials: S
authors.lastname: Pool García
authors.affiliation: Hospital General de Yajalón, Secretaría de Salud, Yajalón, Chiapas, México.
authors.forename: María Lilia
authors.initials: ML
authors.lastname: López-Narvaez
authors.affiliation: Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rodriguez-Perez
keywords: HTR2C gene; Mexican population; polymorphism; serotonin receptor; suicide