title: The Association of Diabetes and Obesity With Prostate Cancer Progression: HCaP-NC.
abstract: BACKGROUND
  The role of race in modifying the association among diabetes, obesity, and prostate cancer (CaP) progression is not well studied. We evaluated diabetes and obesity in association with time to CaP progression in White Americans (Whites) and Black Americans (Blacks).
  
  
  METHODS
  Our study sample consisted of 363 White and 284 Black research participants from the Health Care Access and CaP Treatment in North Carolina (HCaP-NC) cohort. The association between self-reported diabetes or obesity and CaP progression (mean follow-up time approximately 5 years) was assessed using Cox proportional hazards modeling, with adjustment for potential confounders. Stratum-specific hazard ratio (HR) estimates for Whites and Blacks were evaluated.
  
  
  RESULTS
  Self-reported diabetes was not associated with CaP progression in the cohort as a whole (HR: 0.86, 95%CI: 0.54, 1.35), or among racially defined groups (Whites, HR: 1.03, 95%CI: 0.50, 2.13 or Blacks, HR: 0.77, 95%CI: 0.43, 1.39). Obesity was positively associated with CaP progression among Whites, in models including (HR: 1.79, 95%CI: 1.08, 2.97), and excluding (HR: 1.80, 95%CI: 1.09, 2.96) diabetes as a covariate. No association was observed between obesity and CaP progression in Blacks or the cohort as whole.
  
  
  CONCLUSIONS
  Self-reported diabetes was not associated with CaP progression In HCaP-NC. Obesity was associated with CaP progression only among White research participants. Prostate 77:878-887, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Division of Public Health Sciences, Department of Surgery, Washington University in St. Louis School of Medicine, St. Louis, Missouri.|Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Saira
authors.identifier: http://orcid.org/0000-0002-9024-9461
authors.initials: S
authors.lastname: Khan
authors.affiliation: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.|Department of Urology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.|School of Medicine, University of North Carolina-Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Nielsen
authors.affiliation: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.|School of Medicine, University of North Carolina-Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Troester
authors.affiliation: Department of Urology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.|School of Medicine, University of North Carolina-Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.|Department of Urology, Roswell Park Cancer Institute, Buffalo, New York.|Department of Urology, University of Buffalo School of Medicine and Biotechnology, Buffalo, New York.
authors.forename: James L
authors.initials: JL
authors.lastname: Mohler
authors.affiliation: School of Public Health, Louisiana State University Health Science Center, New Orleans, Louisiana.
authors.forename: Elizabeth T H
authors.initials: ETH
authors.lastname: Fontham
authors.affiliation: School of Medicine, University of North Carolina-Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.
authors.forename: Laura H
authors.initials: LH
authors.lastname: Hendrix
authors.affiliation: School of Medicine, University of North Carolina-Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.
authors.forename: Laura
authors.initials: L
authors.lastname: Farnan
authors.affiliation: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.|School of Medicine, University of North Carolina-Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Olshan
authors.affiliation: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.|School of Medicine, University of North Carolina-Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.
authors.forename: Jeannette T
authors.initials: JT
authors.lastname: Bensen
mesh_terms: D000368:Aged; D044383:Black People / Q000706:statistics & numerical data; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000208:ethnology; D018450:Disease Progression; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D009657:North Carolina / Q000453:epidemiology; D009765:Obesity / Q000175:diagnosis / Q000208:ethnology; D016016:Proportional Hazards Models; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000473:pathology; D012307:Risk Factors; D013223:Statistics as Topic; D044465:White People / Q000706:statistics & numerical data; D001741:Black or African American
keywords: Black American; HCaP-NC; diabetes; obesity; progression; prostate cancer