title: Topological knots and links in proteins.
abstract: Twenty years after their discovery, knots in proteins are now quite well understood. They are believed to be functionally advantageous and provide extra stability to protein chains. In this work, we go one step further and search for links-entangled structures, more complex than knots, which consist of several components. We derive conditions that proteins need to meet to be able to form links. We search through the entire Protein Data Bank and identify several sequentially nonhomologous chains that form a Hopf link and a Solomon link. We relate topological properties of these proteins to their function and stability and show that the link topology is characteristic of eukaryotes only. We also explain how the presence of links affects the folding pathways of proteins. Finally, we define necessary conditions to form Borromean rings in proteins and show that no structure in the Protein Data Bank forms a link of this type.
authors.affiliation: Faculty of Chemistry, University of Warsaw, 02-093, Warsaw, Poland.|Centre of New Technologies, University of Warsaw, 02-097, Warsaw, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Dabrowski-Tumanski
authors.affiliation: Faculty of Chemistry, University of Warsaw, 02-093, Warsaw, Poland; jsulkowska@chem.uw.edu.pl.|Centre of New Technologies, University of Warsaw, 02-097, Warsaw, Poland.
authors.forename: Joanna I
authors.initials: JI
authors.lastname: Sulkowska
mesh_terms: D030562:Databases, Protein; D008958:Models, Molecular; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins
keywords: catenanes; disulphide bridge; folding; lasso; slipknot