title: Chronic Myelogenous Leukemia Presenting as a Secondary Malignancy After BCR-ABL1-negative B-lymphoblastic Leukemia/Lymphoma in a Pediatric Patient.
abstract: Chronic myelogenous leukemia, BCR-ABL1 positive (CML) is a rare myeloproliferative neoplasm in children and presents even less often as a secondary malignancy in the pediatric population. Below, we report a patient with Philadelphia-negative B-lymphoblastic leukemia/lymphoma, who developed CML several years after achieving complete remission, and summarize the existing literature on the clinical and pathologic features of CML as a secondary pediatric malignancy.
authors.affiliation: 1 Department of Pediatric Oncology, Pediatric Clinic II, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Popa
authors.affiliation: 1 Department of Pediatric Oncology, Pediatric Clinic II, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Cristina
authors.initials: C
authors.lastname: Blag
authors.affiliation: 2 Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
authors.forename: Horatiu
authors.initials: H
authors.lastname: Olteanu
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis*; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D016315:Proto-Oncogene Proteins c-abl / Q000378:metabolism; D051562:Proto-Oncogene Proteins c-bcr / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C000630408:ABL1 protein, human; D016315:Proto-Oncogene Proteins c-abl; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr
keywords: BCR-ABL1; chronic myelogenous leukemia; cytogenetics; flow cytometry; lymphoblastic leukemia/lymphoma