title: Kitamycin C, a new antimycin-type antibiotic from Streptomyces antibioticus strain 200-09.
abstract: An actinomycete strain 200-09, isolated from a soil sample collected from the coast of Hawaii, USA, was identified as Streptomyces antibioticus on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA analysis. A new antimycin-type antibiotic, kitamycin C (1), together with kitamycin A (2), kitamycin B (3), urauchmycin B (4), deisovaleryblastomycin (5) was isolated from a cultured broth of strain 200-09. The structure of the new compound was determined by spectroscopic data, including HR-ESI-MS and NMR. All the compounds exhibited antifungal activities against Candida albicans with MIC of about 25.0 μg mL-1.
authors.affiliation: a Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research , Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou , China.
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.affiliation: a Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research , Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou , China.
authors.forename: Shu-Na
authors.initials: SN
authors.lastname: Fu
authors.affiliation: a Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research , Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou , China.
authors.forename: Yi-Xuan
authors.initials: YX
authors.lastname: Bao
authors.affiliation: a Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research , Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: b Key Laboratory of New Technique for Plant Protection in Guangdong , Institute of Plant Protection, Guangdong Academy of Agricultural Sciences , Guangzhou , China.
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Shen
authors.affiliation: b Key Laboratory of New Technique for Plant Protection in Guangdong , Institute of Plant Protection, Guangdong Academy of Agricultural Sciences , Guangzhou , China.
authors.forename: Bi-Run
authors.initials: BR
authors.lastname: Lin
authors.affiliation: a Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research , Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou , China.
authors.forename: Guang-Xiong
authors.initials: GX
authors.lastname: Zhou
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D000968:Antimycin A / Q000031:analogs & derivatives / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D018942:Macrolides / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013303:Streptomyces antibioticus / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; C119502:kitamycin A; C000624925:kitamycin C; C000624924:urauchmycin B; C032456:antimycin; D000968:Antimycin A
keywords: Streptomyces antibioticus; antifungal activity; antimycin; kitamycin C