title: Follow-up of Acute kidney injury in Neonates during Childhood Years (FANCY): a prospective cohort study.
abstract: Very low birth weight (VLBW) neonates commonly experience acute kidney injury (AKI) in the neonatal intensive care unit (NICU). We hypothesize that VLBW neonates exposed to AKI in the NICU might be at a higher risk of renal dysfunction during childhood.
  
  
  
  In this cohort study, VLBW children (aged 3-7 years) completed a kidney health evaluation and were stratified according to AKI status in the NICU. The primary outcome was renal dysfunction defined as any of the following: estimated glomerular filtration rate (eGFR) <90 mL/min/1.73 m2, urine protein/creatinine >0.2 or blood pressure ≥95th percentile.
  
  
  
  Thirty-four subjects completed the study. Twenty subjects had a history of neonatal AKI (stage 1, n = 8; stage 2, n = 9; and stage 3, n = 3). At a median age of 5 years, the AKI group had a higher risk of renal dysfunction compared with the group without AKI (65% vs 14%, relative risk 4.5 (1.2-17.1), p = 0.01). Overall, 26% of the total cohort had an eGFR <90 mL/min/1.73 m2using serum cystatin C (35% of AKI subjects, 14% of no AKI subjects, p = 0.25).
  
  
  
  Evidence of renal dysfunction in neonates born VLBW can be found early in childhood. Further work is necessary to determine how to reduce renal disease in this vulnerable population.
authors.affiliation: Division of Neonatology, Department of Pediatrics, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Harer
authors.affiliation: Division of Pediatrics, Department of Radiology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Chelsea F
authors.initials: CF
authors.lastname: Pope
authors.affiliation: Division of Translational Research and Applied Statistics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Conaway
authors.affiliation: Division of Nephrology, Department of Pediatrics, University of Virginia Children's Hospital, Box 800386, Charlottesville, VA, 22908, USA. jrc6n@hscmail.mcc.virginia.edu.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Charlton
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000652:urine; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D001795:Blood Pressure Determination; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood / Q000652:urine; D055316:Cystatin C / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data*; D007677:Kidney Function Tests; D008297:Male; D011446:Prospective Studies; D011507:Proteinuria / Q000652:urine; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D003404:Creatinine
keywords: Chronic kidney disease; Cystatin C; KDIGO; NICU; Prematurity; Very low birth weight