title: Pre-eclampsia: the Potential of GSNO Reductase Inhibitors.
abstract: OBJECTIVE
  Pre-eclampsia remains a leading worldwide cause of maternal death and of perinatal morbidity. There remains no definitive treatment except delivery of the fetus.
  
  
  RESULTS
  Recent insights into the cardiovascular changes that are evident prior to, during, and persist after pre-eclampsia have improved understanding of the underlying pathophysiology-disruption of normal endothelial function and decreased nitric oxide bioavailability. S-nitrosoglutathione (GSNO) is an endogenous S-nitrosothiol that acts as a NO pool and, by replenishing or preventing the breakdown of GSNO, endothelial dysfunction can be ameliorated. GSNO reductase inhibitors are a novel class of drug that can increase NO bioavailability. GSNO reductase inhibitors have demonstrated improvement of endothelial dysfunction in animal models, and in vivo human studies have shown them to be well tolerated. GSNOR inhibitors offer a potentially promising option for the management of pre-eclampsia.
authors.affiliation: Department of Fetal Medicine, Leeds Teaching Hospitals Trust, Leeds, UK. thomaseverett@doctors.net.uk.|University of Leeds, Leeds, UK. thomaseverett@doctors.net.uk.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Everett
authors.affiliation: Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Box 98, Cambridge, UK.
authors.forename: Ian B
authors.initials: IB
authors.lastname: Wilkinson
authors.affiliation: Imperial College London, London, UK.|Imperial College Healthcare NHS Trust, London, UK.|Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
authors.forename: Christoph C
authors.initials: CC
authors.lastname: Lees
mesh_terms: D000818:Animals; D004727:Endothelium / Q000187:drug effects / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D009569:Nitric Oxide / Q000378:metabolism; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D026422:S-Nitrosoglutathione / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D026422:S-Nitrosoglutathione
keywords: GSNO; GSNO reductase inhibitors; Pre-eclampsia; S-nitrosoglutathione