title: The microbiome in allergic disease: Current understanding and future opportunities-2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology.
abstract: PRACTALL is a joint initiative of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology to provide shared evidence-based recommendations on cutting-edge topics in the field of allergy and immunology. PRACTALL 2017 is focused on what has been established regarding the role of the microbiome in patients with asthma, atopic dermatitis, and food allergy. This is complemented by outlining important knowledge gaps regarding its role in allergic disease and delineating strategies necessary to fill these gaps. In addition, a review of progress in approaches used to manipulate the microbiome will be addressed, identifying what has and has not worked to serve as a baseline for future directions to intervene in allergic disease development, progression, or both.
authors.affiliation: Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich.
authors.forename: Yvonne J
authors.initials: YJ
authors.lastname: Huang
authors.affiliation: Service de Pneumologie, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Marsland
authors.affiliation: Division of Allergy and Immunology, Departments of Pediatrics and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
authors.forename: Supinda
authors.initials: S
authors.lastname: Bunyavanich
authors.affiliation: Molecular Immunology, Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland.
authors.forename: Liam
authors.initials: L
authors.lastname: O'Mahony
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, Colo.
authors.forename: Donald Y M
authors.initials: DY
authors.lastname: Leung
authors.affiliation: Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Muraro
authors.affiliation: Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Md. Electronic address: tfleishe@mail.nih.gov.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Fleisher
mesh_terms: D000486:Allergy and Immunology; D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000382:microbiology*; D064307:Microbiota / Q000276:immunology*
keywords: Microbiome; asthma; atopic dermatitis; dysbiosis; food allergy; microbiota; prebiotic; probiotic; systems biology