title: A Two-Input Fluorescent Logic Gate for Glutamate and Zinc.
abstract: The direct visualization of neurotransmitters is a continuing problem in neuroscience; however, functional fluorescent sensors for organic analytes are still rare. Herein, we describe a fluorescent sensor for glutamate and zinc ions. The sensor acts as a fluorescent logic gate, giving a turn-off response to glutamate or zinc ion alone. The combination of analytes produces a large increase in fluorescence. This type of sensor will aid in the study of neurotransmission, in this case, for neurons that copackage high concentrations of zinc and glutamate.
authors.affiliation: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, Institute of Molecular Science, Shanxi University , Taiyuan 030006, China.
authors.forename: Caixia
authors.identifier: 0000-0001-5548-6333
authors.initials: C
authors.lastname: Yin
authors.affiliation: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, Institute of Molecular Science, Shanxi University , Taiyuan 030006, China.
authors.forename: Fangjun
authors.initials: F
authors.lastname: Huo
authors.affiliation: Department of Chemistry, University of Missouri , 601 South College Avenue, Columbia, Missouri 65211, United States.
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Cooley
authors.affiliation: Department of Chemistry, University of Missouri , 601 South College Avenue, Columbia, Missouri 65211, United States.
authors.forename: David
authors.initials: D
authors.lastname: Spencer
authors.affiliation: Department of Chemistry, University of Missouri , 601 South College Avenue, Columbia, Missouri 65211, United States.
authors.forename: Kyle
authors.initials: K
authors.lastname: Bartholomew
authors.affiliation: Department of Chemistry, University of Missouri , 601 South College Avenue, Columbia, Missouri 65211, United States.
authors.forename: Charles L
authors.initials: CL
authors.lastname: Barnes
authors.affiliation: Department of Chemistry, University of Missouri , 601 South College Avenue, Columbia, Missouri 65211, United States.
authors.forename: Timothy E
authors.identifier: 0000-0002-5064-3341
authors.initials: TE
authors.lastname: Glass
mesh_terms: D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D018698:Glutamic Acid / Q000032:analysis*; D018377:Neurotransmitter Agents / Q000032:analysis*; D061848:Optical Imaging / Q000379:methods*; D015032:Zinc / Q000032:analysis*
chemical_list: D005456:Fluorescent Dyes; D018377:Neurotransmitter Agents; D018698:Glutamic Acid; D015032:Zinc
keywords: Fluorescent sensor; glutamate; logic gate; neurotransmitter; zinc