title: Patients with schizophrenia show aberrant patterns of basal ganglia activation: Evidence from ALE meta-analysis.
abstract: The diverse circuits and functional contributions of the basal ganglia, coupled with known differences in dopaminergic function in patients with schizophrenia, suggest they may be an important contributor to the etiology of the hallmark symptoms and cognitive dysfunction experienced by these patients. Using activation-likelihood-estimation meta-analysis of functional imaging research, we investigated differences in activation patterns in the basal ganglia in patients with schizophrenia, relative to healthy controls across task domains. This analysis included 42 functional neuroimaging studies, representing a variety of behavioral domains that have been linked to basal ganglia function in prior work. We provide important new information about the functional activation patterns and functional topography of the basal ganglia for different task domains in healthy controls. Crucially however, we demonstrate that across task domains, patients with schizophrenia show markedly decreased activation in the basal ganglia relative to healthy controls. Our results provide further support for basal ganglia dysfunction in patients with schizophrenia, and the broad dysfunction across task domains may contribute to the symptoms and cognitive deficits associated with schizophrenia.
authors.affiliation: Department of Psychology, Texas A&M University, United States; Texas A&M Institute for Neuroscience, Texas A&M University, United States.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Bernard
authors.affiliation: Department of Psychology & Neuroscience, University of Colorado Boulder, United States.
authors.forename: Courtney E
authors.initials: CE
authors.lastname: Russell
authors.affiliation: Department of Psychology & Neuroscience, University of Colorado Boulder, United States.
authors.forename: Raeana E
authors.initials: RE
authors.lastname: Newberry
authors.affiliation: Department of Psychology, Texas A&M University, United States.
authors.forename: James R M
authors.initials: JR
authors.lastname: Goen
authors.affiliation: Department of Psychology, Northwestern University, United States; Department of Psychiatry, Northwestern University, United States; Institute for Policy Research, Northwestern University, United States; Department of Medical Social Sciences, Northwestern University, United States.
authors.forename: Vijay A
authors.initials: VA
authors.lastname: Mittal
mesh_terms: D001479:Basal Ganglia / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D059906:Neuroimaging / Q000379:methods*; D039781:PubMed / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D012565:Schizophrenic Psychology
keywords: Basal ganglia; Dopamine hypothesis; Meta-analysis; Neuroimaging; Schizophrenia