title: Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery.
abstract: In the present work, we study the role of different components in the formation of more stable iron oxide magnetic nanoparticles (MNPs): β-cyclodextrin (BCD), 2-hydroxypropyl-β-cyclodextrin (HP) and citrate anion. MNPs formulations were characterized by FTIR, particles size measurements, zeta potential based on dynamic light scattering principle technique, X-ray powder pattern diffraction, XPS spectroscopy, transmission electron microscopy and thermogravimetric analysis. The results showed that cyclodextrins and citrate plays a key role in order to obtain a lower size of coated MNPs and proved to be an efficient strategy to obtain a more stable colloidal dispersion, avoiding the nanoparticles oxidation, enhancing the irinotecan incorporation and release. Furthermore, citrate-coated BCD-MNPs showed the same cytotoxicity of the free IRI.
authors.affiliation: Chemistry Department, Exact Sciences Institute, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
authors.forename: Ana P F
authors.initials: APF
authors.lastname: Monteiro
authors.affiliation: Chemistry Department, Exact Sciences Institute, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
authors.forename: Larissa D
authors.initials: LD
authors.lastname: Caminhas
authors.affiliation: Centro de Desenvolvimento da Tecnologia Nuclear, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
authors.forename: José D
authors.initials: JD
authors.lastname: Ardisson
authors.affiliation: Physical Department, Exact Science Institute, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Paniago
authors.affiliation: Restorative Dentistry Department, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Cortés
authors.affiliation: Chemistry Department, Exact Sciences Institute, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil. Electronic address: sinisterra@ufmg.br.
authors.forename: Rubén D
authors.initials: RD
authors.lastname: Sinisterra
keywords: Cancer; Citrate; Cyclodextrin; Irinotecan; Magnetic nanoparticle