title: Catechin-Bound Ceanothane-Type Triterpenoid Derivatives from the Roots of Zizyphus jujuba.
abstract: Three unprecedented ceanothane-type triterpenoids, ent-epicatechinoceanothic acid A (1), ent-epicatechinoceanothic acid B (2), and epicatechino-3-deoxyceanothetric acid A (3), containing C-C bond linkages with catechin moieties, were isolated from the roots of Zizyphus jujuba. Their chemical structures, including absolute configurations, were established by spectroscopic analysis and calculation of their ECD spectra. A possible biogenetic pathway for C-C bond formation between the catechin and the triterpenoid moieties is presented. Compound 1 was evaluated for its antiproliferative activity on HSC-T6 hepatic stellate cells.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Seoul 08826, Republic of Korea.
authors.forename: Kyo Bin
authors.identifier: 0000-0003-3290-1017
authors.initials: KB
authors.lastname: Kang
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Seoul 08826, Republic of Korea.
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Kim
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Seoul 08826, Republic of Korea.
authors.forename: Jung Wha
authors.initials: JW
authors.lastname: Kim
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Seoul 08826, Republic of Korea.
authors.forename: Won Keun
authors.initials: WK
authors.lastname: Oh
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Seoul 08826, Republic of Korea.
authors.forename: Jinwoong
authors.identifier: 0000-0001-9579-738X
authors.initials: J
authors.lastname: Kim
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Seoul 08826, Republic of Korea.
authors.forename: Sang Hyun
authors.identifier: 0000-0002-0527-4815
authors.initials: SH
authors.lastname: Sung
mesh_terms: D002392:Catechin / Q000737:chemistry*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D056910:Republic of Korea; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*; D031957:Ziziphus / Q000737:chemistry*
chemical_list: D014315:Triterpenes; C549430:ceanothane; C000621325:ent-epicatechinoceanothic acid A; D002392:Catechin