title: Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers.
abstract: Nanometric biocompatible Metal-Organic Frameworks (nanoMOFs) are promising candidates for drug delivery. Up to now, most studies have targeted the intravenous route, related to pain and severe complications; whereas nanoMOFs for oral administration, a commonly used non-invasive and simpler route, remains however unexplored. We propose here the biofriendly preparation of a suitable oral nanocarrier based on the benchmarked biocompatible mesoporous iron(III) trimesate nanoparticles coated with the bioadhesive polysaccharide chitosan (CS). This method does not hamper the textural/structural properties and the sorption/release abilities of the nanoMOFs upon surface engineering. The interaction between the CS and the nanoparticles has been characterized through a combination of high resolution soft X-ray absorption and computing simulation, while the positive impact of the coating on the colloidal and chemical stability under oral simulated conditions is here demonstrated. Finally, the intestinal barrier bypass capability and biocompatibility of CS-coated nanoMOF have been assessed in vitro, leading to an increased intestinal permeability with respect to the non-coated material, maintaining an optimal biocompatibility. In conclusion, the preservation of the interesting physicochemical features of the CS-coated nanoMOF and their adapted colloidal stability and progressive biodegradation, together with their improved intestinal barrier bypass, make these nanoparticles a promising oral nanocarrier.
authors.affiliation: Institut Lavoisier, CNRS UMR 8180, Université de Versailles Saint-Quentin-en-Yvelines, 45 Av. des Etats-Unis, 78035 Versailles cedex, University Paris-Saclay, France.
authors.forename: T
authors.initials: T
authors.lastname: Hidalgo
authors.affiliation: Institut Lavoisier, CNRS UMR 8180, Université de Versailles Saint-Quentin-en-Yvelines, 45 Av. des Etats-Unis, 78035 Versailles cedex, University Paris-Saclay, France.
authors.forename: M
authors.initials: M
authors.lastname: Giménez-Marqués
authors.affiliation: Institut Lavoisier, CNRS UMR 8180, Université de Versailles Saint-Quentin-en-Yvelines, 45 Av. des Etats-Unis, 78035 Versailles cedex, University Paris-Saclay, France.
authors.forename: E
authors.initials: E
authors.lastname: Bellido
authors.affiliation: Synchrotron SOLEIL &Université Paris-Saclay, L'Orme des Merisiers, Saint-Aubin - BP48, 91192 Gif-sur-Yvette Cedex, France.
authors.forename: J
authors.initials: J
authors.lastname: Avila
authors.affiliation: Synchrotron SOLEIL &Université Paris-Saclay, L'Orme des Merisiers, Saint-Aubin - BP48, 91192 Gif-sur-Yvette Cedex, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Asensio
authors.affiliation: ICGM - UMR5253- Equipe AIME, Université Montpellier II, 2 Place Eugène Bataillon - CC 1502, 34095 Montpellier CEDEX 5, France.
authors.forename: F
authors.initials: F
authors.lastname: Salles
authors.affiliation: Institut Lavoisier, CNRS UMR 8180, Université de Versailles Saint-Quentin-en-Yvelines, 45 Av. des Etats-Unis, 78035 Versailles cedex, University Paris-Saclay, France.
authors.forename: M V
authors.initials: MV
authors.lastname: Lozano
authors.affiliation: Institut Lavoisier, CNRS UMR 8180, Université de Versailles Saint-Quentin-en-Yvelines, 45 Av. des Etats-Unis, 78035 Versailles cedex, University Paris-Saclay, France.
authors.forename: M
authors.initials: M
authors.lastname: Guillevic
authors.affiliation: Immunology, Biomedical Research Center (CINBIO) and Institute of Biomedical Research of Vigo (IBIV), Universidad de Vigo, Campus Lagoas Marcosende, 36310 Vigo, Pontevedra, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Simón-Vázquez
authors.affiliation: Immunology, Biomedical Research Center (CINBIO) and Institute of Biomedical Research of Vigo (IBIV), Universidad de Vigo, Campus Lagoas Marcosende, 36310 Vigo, Pontevedra, Spain.
authors.forename: A
authors.initials: A
authors.lastname: González-Fernández
authors.affiliation: Institut Lavoisier, CNRS UMR 8180, Université de Versailles Saint-Quentin-en-Yvelines, 45 Av. des Etats-Unis, 78035 Versailles cedex, University Paris-Saclay, France.
authors.forename: C
authors.initials: C
authors.lastname: Serre
authors.affiliation: Nanobiofar. Center for Molecular Medicine and Chronic Diseases (CIMUS), Universidad de Santiago de Compostela, Av. Barcelona s/n, Campus Vida, 15706 Santiago de Compostela, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Alonso
authors.affiliation: Institut Lavoisier, CNRS UMR 8180, Université de Versailles Saint-Quentin-en-Yvelines, 45 Av. des Etats-Unis, 78035 Versailles cedex, University Paris-Saclay, France.|IMDEA Energy, Av. Ramón de la Sagra 3, 28935 Móstoles, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Horcajada
mesh_terms: D000284:Administration, Oral; D018938:Caco-2 Cells; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D065546:Drug Liberation; D020895:Enterocytes / Q000378:metabolism*; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008238:Lysergic Acid Diethylamide / Q000031:analogs & derivatives / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D005290:Ferric Compounds; C048042:N(1)-methyl-2-lysergic acid diethylamide; D008238:Lysergic Acid Diethylamide; D048271:Chitosan