title: Familial Mediterranean fever associated with optic neuritis, successfully treated with anti-interleukin 1 agents.
abstract: Familial Mediterranean fever (FMF) is an inherited periodic auto-inflammatory disease characterized by recurrent attacks of fever, synovitis and serositis. Ophthalmological manifestations of FMF are extremely rare. Here we described a boy who has been followed-up for FMF and attended with a loss of vision during the course of the disease. He was diagnosed with optic neuritis. As the other etiologies were excluded his optic neuritis was attributed to the underlying auto inflammatory process. After pulse steroid therapy, his symptoms improved and a complete remission occurred. Afterwards he had two more optic neuritis attacks. Thereafter anti-interleukin 1 (IL-1) drugs were introduced and he did not develop further attacks of both optic neuritis and FMF. This case presentation highlights the possible association between FMF and optic nerve involvement.
authors.affiliation: Departments of Pediatric Rheumatology, Ankara Child Health, Hematology, Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Özge
authors.initials: Ö
authors.lastname: Başaran
authors.affiliation: Ankara Ulucanlar Eye Hospital, Ankara, Turkey.
authors.forename: Sevim
authors.initials: S
authors.lastname: Kavuncu
authors.affiliation: Departments of Pediatric Neurology, Ankara Child Health, Hematology, Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Alev
authors.initials: A
authors.lastname: Güven
authors.affiliation: Departments of Pediatric Rheumatology, Ankara Child Health, Hematology, Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Nermin
authors.initials: N
authors.lastname: Uncu
authors.affiliation: Departments of Pediatric Rheumatology, Ankara Child Health, Hematology, Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Acar-Çelikel
authors.affiliation: Departments of Pediatric Rheumatology, Ankara Child Health, Hematology, Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Nilgün
authors.initials: N
authors.lastname: Çakar
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D002675:Child, Preschool; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007375:Interleukin-1 / Q000037:antagonists & inhibitors*; D008297:Male; D009902:Optic Neuritis / Q000150:complications* / Q000188:drug therapy
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007375:Interleukin-1; C541220:canakinumab
keywords: anti interleukin-1 agents; child; familial Mediterranean fever; optic neuritis