title: Negative correlation between cerebrospinal fluid FGF21 levels and BDI scores in male Chinese subjects.
abstract: Fibroblast growth factor 21 (FGF21) is an important metabolic regulator of glucose homeostasis and lipid metabolism. Recently, FGF21 has been shown to play a robust neuroprotective role and act as a mediator of the effects of mood stabilizers. In the present study, we measured the concentration of FGF21 in human cerebrospinal fluid (CSF) and investigated the relationship of FGF21 levels with depression and anxiety emotions. Sixty-seven Chinese volunteers were recruited from Beijing Jishuitan Hospital. A significant negative association was found between CSF FGF21 levels and Beck Depression Inventory (BDI) scores in male subjects. Our findings provide evidence of the role of FGF21 in mood regulation.
authors.affiliation: College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China; Collaborative Innovation Center of Biomedicine, Wenzhou University, Wenzhou 325035, China.
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot 010110, China.
authors.forename: Meiling
authors.initials: M
authors.lastname: Wang
authors.affiliation: College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China; Collaborative Innovation Center of Biomedicine, Wenzhou University, Wenzhou 325035, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Tan
authors.affiliation: College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Beijing Jishuitan Hospital, Beijing 100035, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Yang
authors.affiliation: College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
authors.affiliation: College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: xiaokunli@163.com.
authors.forename: Xiaokun
authors.initials: X
authors.lastname: Li
authors.affiliation: Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China; Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China. Electronic address: FanWang@bjmu.edu.cn.
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
mesh_terms: D000328:Adult; D001007:Anxiety / Q000134:cerebrospinal fluid; D044466:Asian People / Q000523:psychology*; D002681:China; D003863:Depression / Q000134:cerebrospinal fluid*; D005346:Fibroblast Growth Factors / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales
chemical_list: C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors
keywords: BDI; FGF21; SAS