title: A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex.
abstract: Herein, we report a novel approach for the design of a colorimetric aptasensor based on functionalized gold nanoparticle probes. This approach relies on the conjugation of nanoparticles by two functional DNA and RNA hairpins that engage specific kissing (loop-loop) interactions in response to the addition of a small analyte ligand, leading to particle aggregation and then red-to-purple colour change of the colloidal solution.
authors.affiliation: University Grenoble Alpes, DPM CNRS UMR 5063, F-38041 Grenoble, France. eric.peyrin@univ-grenoble-alpes.fr valerie.guieu@univ-grenoble-alpes.fr.
authors.forename: E
authors.initials: E
authors.lastname: Goux
authors.affiliation: Laboratoire ARNA, University of Bordeaux, Inserm U1212, CNRS UMR5320, F-33076 Bordeaux, France.
authors.forename: E
authors.initials: E
authors.lastname: Dausse
authors.affiliation: University Grenoble Alpes, DPM CNRS UMR 5063, F-38041 Grenoble, France. eric.peyrin@univ-grenoble-alpes.fr valerie.guieu@univ-grenoble-alpes.fr.
authors.forename: V
authors.initials: V
authors.lastname: Guieu
authors.affiliation: Laboratoire ARNA, University of Bordeaux, Inserm U1212, CNRS UMR5320, F-33076 Bordeaux, France.
authors.forename: L
authors.initials: L
authors.lastname: Azéma
authors.affiliation: Laboratoire ARNA, University of Bordeaux, Inserm U1212, CNRS UMR5320, F-33076 Bordeaux, France.
authors.forename: G
authors.initials: G
authors.lastname: Durand
authors.affiliation: University Grenoble Alpes, DPM CNRS UMR 5063, F-38041 Grenoble, France. eric.peyrin@univ-grenoble-alpes.fr valerie.guieu@univ-grenoble-alpes.fr.
authors.forename: M
authors.initials: M
authors.lastname: Henry
authors.affiliation: University Grenoble Alpes, DPM CNRS UMR 5063, F-38041 Grenoble, France. eric.peyrin@univ-grenoble-alpes.fr valerie.guieu@univ-grenoble-alpes.fr.
authors.forename: L
authors.initials: L
authors.lastname: Choisnard
authors.affiliation: Laboratoire ARNA, University of Bordeaux, Inserm U1212, CNRS UMR5320, F-33076 Bordeaux, France.
authors.forename: J-J
authors.initials: JJ
authors.lastname: Toulmé
authors.affiliation: University Grenoble Alpes, DPM CNRS UMR 5063, F-38041 Grenoble, France. eric.peyrin@univ-grenoble-alpes.fr valerie.guieu@univ-grenoble-alpes.fr.
authors.forename: C
authors.initials: C
authors.lastname: Ravelet
authors.affiliation: University Grenoble Alpes, DPM CNRS UMR 5063, F-38041 Grenoble, France. eric.peyrin@univ-grenoble-alpes.fr valerie.guieu@univ-grenoble-alpes.fr.
authors.forename: E
authors.identifier: http://orcid.org/0000-0001-5558-6369
authors.initials: E
authors.lastname: Peyrin