title: Analysis of the skin of mice humanized for the immune system.
abstract: Development of new immunotherapeutic strategies relies on the ability to activate the right cells at the right place and at the right moment and on the capacity of these cells to home to the right organ(s). Skin delivery has shown high potency for immunotherapeutic administration. However, an adequate in vivo model of human skin immunity is still a critical bottleneck. We demonstrated here that the skin of human immune system mice is colonized by human hematopoietic cells, mainly human T cells and that complementation with human antigen-presenting cells at the vaccination site allowed the induction of an immune response.
authors.affiliation: UMR_S CR7, Centre d'Immunologie et des Maladies Infectieuses- Paris (CIMI-Paris), Sorbonne Universités, UPMC University Paris 06, Paris, France.|INSERM U1135, CIMI-Paris, Paris, France.
authors.forename: Mireille
authors.initials: M
authors.lastname: Centlivre
authors.affiliation: UMR_S CR7, Centre d'Immunologie et des Maladies Infectieuses- Paris (CIMI-Paris), Sorbonne Universités, UPMC University Paris 06, Paris, France.|INSERM U1135, CIMI-Paris, Paris, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Petit
authors.affiliation: UMR_S CR7, Centre d'Immunologie et des Maladies Infectieuses- Paris (CIMI-Paris), Sorbonne Universités, UPMC University Paris 06, Paris, France.|INSERM U1135, CIMI-Paris, Paris, France.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Hutton
authors.affiliation: UMR_S CR7, Centre d'Immunologie et des Maladies Infectieuses- Paris (CIMI-Paris), Sorbonne Universités, UPMC University Paris 06, Paris, France.|INSERM U1135, CIMI-Paris, Paris, France.
authors.forename: Mélody
authors.initials: M
authors.lastname: Dufossée
authors.affiliation: UMR_S CR7, Centre d'Immunologie et des Maladies Infectieuses- Paris (CIMI-Paris), Sorbonne Universités, UPMC University Paris 06, Paris, France.|INSERM U1135, CIMI-Paris, Paris, France.|Service de Chirurgie Plastique, Reconstructrice, Esthétique, Centre de Brûlées, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.
authors.forename: David
authors.initials: D
authors.lastname: Boccara
authors.affiliation: Service de Chirurgie Plastique, Reconstructrice, Esthétique, Centre de Brûlées, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.
authors.forename: Maurice
authors.initials: M
authors.lastname: Mimoun
authors.affiliation: UMR_S CR7, Centre d'Immunologie et des Maladies Infectieuses- Paris (CIMI-Paris), Sorbonne Universités, UPMC University Paris 06, Paris, France.|INSERM U1135, CIMI-Paris, Paris, France.|Service de Dermatologie et Allergologie, Hôpital Tenon, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.
authors.forename: Angèle
authors.initials: A
authors.lastname: Soria
authors.affiliation: UMR_S CR7, Centre d'Immunologie et des Maladies Infectieuses- Paris (CIMI-Paris), Sorbonne Universités, UPMC University Paris 06, Paris, France.|INSERM U1135, CIMI-Paris, Paris, France.
authors.forename: Béhazine
authors.identifier: 0000-0002-2353-4406
authors.initials: B
authors.lastname: Combadière
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D015789:HLA-A2 Antigen / Q000235:genetics* / Q000378:metabolism; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D017493:Leukocyte Common Antigens / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D023421:Models, Animal; D012867:Skin / Q000166:cytology* / Q000276:immunology*; D014183:Transplantation, Heterologous
chemical_list: D018952:Antigens, CD34; D015789:HLA-A2 Antigen; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human
keywords: antigen-presenting cells; human immune system mice; intra-dermal vaccination; route of administration; skin T cells