title: Transition-Metal-Free β-C-H Bond Carbonylation of Enamides or Amides with a Trifluoromethyl Group as CO Surrogate for the Synthesis of 1,3-Oxazin-6-ones.
abstract: A cascade β-C-H bond trifluoromethylation/C(sp3)-F bond activation/hydrolysis reaction of enamides with Togni's reagent has been disclosed. This formal C-H bond carbonylation reaction utilizes the CF3group as a CO surrogate to provide an efficient approach to 1,3-oxazin-6-ones in satisfactory yields. Furthermore, CF3-containing 1,3-oxazin-6-ones could also be accessed using this method by using alkenyl N-ethylamides involving the functionalization of one Csp2-H, one Csp3-H, one Csp2-H, and three Csp3-F bonds. The broad substrate scope of this method enables access to synthetically or pharmaceutically important compounds, which are difficult to access by known methods.
authors.affiliation: Department of Chemistry, Jinan University , Guangzhou, Guangdong 510632, P. R. China.|Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Song
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yu
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
authors.forename: Jin-Shun
authors.initials: JS
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Jinan University , Guangzhou, Guangdong 510632, P. R. China.
authors.forename: Yiqun
authors.identifier: 0000-0002-3303-1730
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
authors.forename: Ning-Yuan
authors.initials: NY
authors.lastname: Yang
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.
authors.forename: Xin-Yuan
authors.identifier: 0000-0002-6978-6465
authors.initials: XY
authors.lastname: Liu