title: A Microbiome Foundation for the Study of Crohn's Disease.
abstract: Our 2014 study published in Cell Host & Microbe, "The Treatment-Naive Microbiome in New-Onset Crohn's Disease," was designed to improve our understanding of the microbiome's role in Crohn's disease by studying a unique, well-suited cohort and sample set. This commentary provides a hindsight perspective of this original study as well as future outlook.
authors.affiliation: Janssen Human Microbiome Institute at Janssen Research and Development LLC, Cambridge, MA 02142, USA. Electronic address: dgevers3@its.jnj.com.
authors.forename: Dirk
authors.initials: D
authors.lastname: Gevers
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Emory University, Atlanta, GA 30322, USA.
authors.forename: Subra
authors.initials: S
authors.lastname: Kugathasan
authors.affiliation: Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55108, USA; BioTechnology Institute, University of Minnesota, St. Paul, MN 55108, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Knights
authors.affiliation: Research Division, Joslin Diabetes Center, Boston, MA 02215, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Aleksandar D
authors.initials: AD
authors.lastname: Kostic
authors.affiliation: BioFrontiers Institute, University of Colorado, Boulder, CO 80309, USA; Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA; Howard Hughes Medical Institute, Boulder, CO 80309, USA.
authors.forename: Rob
authors.initials: R
authors.lastname: Knight
authors.affiliation: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Ramnik J
authors.initials: RJ
authors.lastname: Xavier
mesh_terms: D003424:Crohn Disease / Q000209:etiology* / Q000382:microbiology* / Q000473:pathology; D000069196:Gastrointestinal Microbiome; D006801:Humans; D064307:Microbiota