title: Rosuvastatin promotes benefits on induced periodontitis in hypertensive rats.
abstract: OBJECTIVE
  The potential benefits of statins in modulating periodontal disease is supported by in vitro and clinical studies showing statins can induce a lower expression of proinflammatory cytokines and matrix metalloproteinases. The aim of this study was to evaluate the effects of rosuvastatin (ST) on ligature-induced periodontitis in spontaneously hypertensive rats (SHR).
  
  
  METHODS
  Fifty-four adult male rats were divided into three groups: SHR-C, SHR-L and SHR-L-ST (C, control; L, ligature groups). In the SHR-L-ST group, animals were treated with daily 2 mg/kg ST administration. In L groups, a ligature remained around mandibular first molars for 10 d. Each group was divided for killing at 10 or 21 d postoperatively. Microtomographic and histometric analyses were performed. Osteoclastogenesis was evaluated by tartrate-resistant acid phosphatase assay and gene expression of 84 proinflammatory mediators by polymerase chain reaction array.
  
  
  RESULTS
  The SHR-L-ST group showed reduced bone loss and attachment loss in comparison with the SHR-L group at both 10 and 21 d postoperatively (p < 0.05). ST decreased the amount of tartrate-resistant acid phosphatase-positive cells compared with the SHR-L group at both 10 and 21 d (p < 0.05). The SHR-L-ST group presented 14 genes differentially expressed when compared with SHR-L group, featuring a downregulated gene profile at 10 d.
  
  
  CONCLUSIONS
  Statin therapy may promote a protective effect against alveolar bone and connective tissue attachment losses attributable to periodontitis in hypertensive rats through inflammatory gene profile modulation.
authors.affiliation: Department of Oral Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: M R
authors.initials: MR
authors.lastname: Messora
authors.affiliation: Department of Oral Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: G H
authors.initials: GH
authors.lastname: Apolinário Vieira
authors.affiliation: Department of Oral Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: J M T M M
authors.initials: JMTMM
authors.lastname: Vanderlei
authors.affiliation: Department of Oral Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: V C
authors.initials: VC
authors.lastname: Mariguela
authors.affiliation: Department of Oral Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: P G
authors.initials: PG
authors.lastname: Fernandes
authors.affiliation: Department of Oral Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: D B
authors.initials: DB
authors.lastname: Palioto
authors.affiliation: Department of Oral Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: S L
authors.initials: SL
authors.lastname: Scombatti de Souza
authors.affiliation: Department of Oral Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: A B
authors.initials: AB
authors.lastname: Novaes
authors.affiliation: Department of Oral Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Furlaneto
authors.affiliation: Department of Oral Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Taba
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D015870:Gene Expression; D008026:Ligation; D008297:Male; D008334:Mandible; D010010:Osteoclasts / Q000187:drug effects; D010518:Periodontitis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D016133:Polymerase Chain Reaction; D051381:Rats; D011918:Rats, Inbred SHR; D000068718:Rosuvastatin Calcium / Q000494:pharmacology*; D055114:X-Ray Microtomography
chemical_list: D015415:Biomarkers; D016207:Cytokines; D000068718:Rosuvastatin Calcium
keywords: coronary heart disease(s); genetics; inflammation; periodontitis