title: Novel refractive index biosensing of microcontact printed molecules on lithium niobate.
abstract: This work demonstrates, for the first time, the use of lithium niobate as a biosensor that detects local refractive index changes triggered by the presence of biomolecules on its surface. The sensitivity of the sensor was found to be 242±16 nm/RIU. As a case study, we immobilized proteins (IgG antibodies) using micro-contact printing to demonstrate sensing capabilities of the device. The validated proof of concept lays a foundation for developing lithium niobate based novel optical biosensors.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Bhalla
authors.forename: Shivani
authors.initials: S
authors.lastname: Sathish
authors.forename: Amy Q
authors.initials: AQ
authors.lastname: Shen
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods; D009556:Niobium / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D012031:Refractometry / Q000295:instrumentation / Q000379:methods
chemical_list: D010087:Oxides; D009556:Niobium; C091692:lithium niobate