title: Post-reexposure administration of D-cycloserine facilitates reconsolidation of contextual conditioned fear memory in rats.
abstract: The effect of D-cycloserine, a N-methyl-D-aspartate receptor partial agonist, on the reconsolidation of conditioned fear memory is not precisely understood. In this study, we clarified the effects of D-cycloserine on the reconsolidation in rats, by performing contextual fear conditioning with a mild fear-conditioning procedure and with post-reexposure administration of the drug. The D-cycloserine (15 mg/kg subcutaneously)-treated rats showed a persistent and greater fear response during the test session compared with the control group. In conclusion, we have confirmed that post-reexposure administration of D-cycloserine facilitates the reconsolidation of fear memory in rats.
authors.affiliation: Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashimachi, Kodaira, Tokyo, 187-8553, Japan.
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Saitoh
authors.affiliation: Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashimachi, Kodaira, Tokyo, 187-8553, Japan.|Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
authors.forename: Kie
authors.initials: K
authors.lastname: Akagi
authors.affiliation: Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
authors.forename: Jun-Ichiro
authors.initials: JI
authors.lastname: Oka
authors.affiliation: Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashimachi, Kodaira, Tokyo, 187-8553, Japan. mitsu@ncnp.go.jp.
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects*; D003523:Cycloserine / Q000008:administration & dosage*; D005108:Extinction, Psychological / Q000187:drug effects; D005239:Fear / Q000187:drug effects*; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects; D008297:Male; D000069077:Memory Consolidation / Q000187:drug effects*; D008874:Midazolam / Q000008:administration & dosage; D018697:Nootropic Agents / Q000008:administration & dosage*; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D018697:Nootropic Agents; D003523:Cycloserine; D008874:Midazolam
keywords: Contextual fear conditioning; D-Cycloserine; Extinction; Midazolam; Reconsolidation