title: [Investigation of CNTF, COMT, DDR1, DISC1, DRD2, DRD3, and DTNBP1 candidate genes in schizophrenia: Results from the Hungarian SCHIZOBANK Consortium].
abstract: Schizophrenia is a chronic, debilitating psychiatric disorder characterized by heterogeneous clinical symptoms. Although the pathogenesis of this disorder is poorly understood, several lines of evidence support the role of both common and rare genetic variants in the etiology of schizophrenia. Common variants, single nucleotide polymorphisms can be investigated by candidate gene association studies or genome-wide association studies, while rare variants, single nucleotide variants are assessable by means of candidate gene resequencing or whole-exome and genome sequencing using next generation sequencing. In this study we investigated polymorphisms of 7 candidate genes in a Hungarian schizophrenia cohort. Candidate genes were chosen on the basis of previous results and biological plausibility. 390 patients were recruited in 5 centers in the framework of the Hungarian SCHIZOBANK Consortium, the schizophrenia sample was contrasted to 1069 healthy control individuals. In this sample SNPs of DDR1 and DRD2 genes demonstrated significant association with schizophrenia. The role of DDR1 and DRD2 genes in the etiology of schizophrenia warrant further investigation, based on their genomic localization and biological functions.
authors.affiliation: Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary. rethelyi.janos@med.semmelweis-univ.hu.
authors.forename: Judit
authors.initials: J
authors.lastname: Benkovits
authors.forename: Szilvia
authors.initials: S
authors.lastname: Magyarosi
authors.forename: Attila J
authors.initials: AJ
authors.lastname: Pulay
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Makkos
authors.forename: Aniko
authors.initials: A
authors.lastname: Egerhazi
authors.forename: Nora
authors.initials: N
authors.lastname: Balogh
authors.forename: Peter
authors.initials: P
authors.lastname: Almos
authors.forename: Istvan
authors.initials: I
authors.lastname: Liko
authors.forename: Hungarian
authors.initials: H
authors.lastname: Schizobank Consortium
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Nemeth
authors.forename: Judit Maria
authors.initials: JM
authors.lastname: Molnar
authors.forename: Laszlo
authors.initials: L
authors.lastname: Nagy
authors.forename: Janos M
authors.initials: JM
authors.lastname: Rethelyi
mesh_terms: D020934:Ciliary Neurotrophic Factor; D000070819:Discoidin Domain Receptor 1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D006814:Hungary; D020641:Polymorphism, Single Nucleotide; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D020934:Ciliary Neurotrophic Factor; C581293:DRD2 protein, human; D017448:Receptors, Dopamine D2; C092030:DDR1 protein, human; D000070819:Discoidin Domain Receptor 1