title: Peptide-Based and Polypeptide-Based Gene Delivery Systems.
abstract: Peptide-based and polypeptide-based gene carriers are emerging as the most potentially useful agents in the field of gene therapy. Here we summarize the methods used for the preparation of peptides and polypeptides, address the primary types of peptide-based gene delivery systems, demonstrate their applications in gene therapy, and attempt to propose possible future directions in the development of peptide-based and polypeptide-based gene carriers for specific applications.
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Xiuwen
authors.initials: X
authors.lastname: Guan
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. thy@ciac.ac.cn.
authors.forename: Huayu
authors.identifier: http://orcid.org/0000-0002-2482-3744
authors.initials: H
authors.lastname: Tian
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000737:chemistry; D006801:Humans; D010455:Peptides / Q000737:chemistry*
chemical_list: D010455:Peptides
keywords: Gene delivery; Gene vaccine; Genetic disorders; Multifunctional; Polymeric carriers; Polypeptide