title: Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases.
abstract: microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the pathological initiation and progression of many human diseases. miR-221 and miR-222 (miR-221/222) are two highly homologous miRNAs, and they are significantly overexpressed in several types of human diseases. Silencing miR-221/222 could represent a promising approach for therapeutic studies. In the present review, we will describe the potential value of miR-221/222 as diagnostic, prognostic, and therapeutic biomarkers in various diseases including cancer and inflammatory diseases.
authors.affiliation: Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China; Shanghai University of Medicine & Health, Shanghai Sixth People's Hospital East Campus, Shanghai, China.
authors.forename: Jialin
authors.initials: J
authors.lastname: Song
authors.affiliation: Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China; Shanghai University of Medicine & Health, Shanghai Sixth People's Hospital East Campus, Shanghai, China.
authors.forename: Yuanming
authors.initials: Y
authors.lastname: Ouyang
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University , Shanghai , China.
authors.forename: Junyi
authors.initials: J
authors.lastname: Che
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University , Shanghai , China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University , Shanghai , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University , Shanghai , China.
authors.forename: Kejia
authors.initials: K
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University , Shanghai , China.
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Jinshan Hospital, Fudan University , Shanghai , China.
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , China.
authors.forename: Cunyi
authors.initials: C
authors.lastname: Fan
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University , Shanghai , China.
authors.forename: Weien
authors.initials: W
authors.lastname: Yuan
keywords: biomarker; diagnosis; diseases; miR-221/222; microRNAs; prognosis; therapy