title: A strategy for photothermal conversion of polymeric nanoparticles by polyaniline for smart control of targeted drug delivery.
abstract: The near-infrared (NIR)-mediated novel strategy to control the drug release from nanocarriers has developed rapidly in recent decades. Polyaniline as a non-cytotoxic and electroactive material for studying cellular proliferation has attracted great attention in recent years. In the present work, polyaniline-mediated polymeric nanoparticles were developed to target the delivery of cisplatin and release it in a controllable way. The prepared polyaniline nanoparticles displayed a size of 90 ± 1.0 nm, a favorable morphology in water, and could be targeted to tumors through the high affinity between trastuzumab and the overexpressed Her2 in tumor cells. In addition, the developed nanoparticles demonstrated exciting photothermal conversion efficiency induced by NIR light and achieved significant cell inhibition efficiency (93.97%) in vitro when exposed to an 808 nm NIR laser with the power of 1.54 W for 5 min. Therefore, the developed external control release delivery system with excellent specificity and high cytotoxicity exhibited great potential in cell research and our research demonstrated that the polyaniline also has potential in the application of photothermal conversion in biomedicine.
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210089, People's Republic of China.
authors.forename: Chaoqun
authors.initials: C
authors.lastname: You
authors.forename: Hongshuai
authors.initials: H
authors.lastname: Wu
authors.forename: Mingxin
authors.initials: M
authors.lastname: Wang
authors.forename: Senlin
authors.initials: S
authors.lastname: Wang
authors.forename: Tianyi
authors.initials: T
authors.lastname: Shi
authors.forename: Yanghui
authors.initials: Y
authors.lastname: Luo
authors.forename: Baiwang
authors.initials: B
authors.lastname: Sun
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D000074322:Antineoplastic Agents, Immunological / Q000008:administration & dosage; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D010316:Particle Size; D010777:Photochemistry / Q000379:methods; D010778:Photochemotherapy / Q000379:methods; D011108:Polymers / Q000737:chemistry; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D000068878:Trastuzumab / Q000008:administration & dosage*
chemical_list: D000814:Aniline Compounds; D000074322:Antineoplastic Agents, Immunological; D004337:Drug Carriers; D011108:Polymers; D018719:Erb-b2 Receptor Tyrosine Kinases; D000068878:Trastuzumab; C416807:polyaniline; C508053:ERBB2 protein, human