title: Engineering based assessment for a shape design of a pediatric ePTFE pulmonary conduit valve.
abstract: The authors examined the hemodynamic characteristics of expanded polytetrafluoroethylene (ePTFE) pulmonary valved conduits quantitatively by our originally developed pediatric pulmonary mechanical circulatory system, in order to suggest the optimal shape design. The system consisted of pneumatically driven right atrium and ventricle model, a pulmonary valve chamber, and elastic pulmonary compliance model with peripheral vascular resistance units, a venous reservoir. We employed two different types of ePTFE valve and evaluated the relationship between the leaflets motion and hemodynamic characteristics by using a high-speed video camera. As a result, we successfully reproduced hemodynamic simulations in our pediatric pulmonary mock system. We confirmed that the presence of bulging sinuses in the pulmonary valved conduit reduced the transvalvular energy loss and increased the valve opening area during systolic period. Our engineering-based in vitro analysis could be useful for proposing a shape design optimization of sophisticated pediatric ePTFE pulmonary valve.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tsuboko
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Shiraishi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yamada
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yambe
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Miura
authors.forename: Seitaro
authors.initials: S
authors.lastname: Mura
authors.forename: Masaaki
authors.initials: M
authors.lastname: Yamagishi
mesh_terms: D001698:Biomedical Engineering; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006352:Heart Ventricles / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D011138:Polytetrafluoroethylene / Q000737:chemistry*; D011474:Prosthesis Design; D011664:Pulmonary Valve / Q000502:physiology*
chemical_list: D011138:Polytetrafluoroethylene