title: Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation.
abstract: Early hearing deprivation could affect the development of auditory, language, and vision ability. Insufficient or no stimulation of the auditory cortex during the sensitive periods of plasticity could affect the function of hearing, language, and vision development. Twenty-three infants with congenital severe sensorineural hearing loss (CSSHL) and 17 age and sex matched normal hearing subjects were recruited. The amplitude of low frequency fluctuations (ALFF) and regional homogeneity (ReHo) of the auditory, language, and vision related brain areas were compared between deaf infants and normal subjects. Compared with normal hearing subjects, decreased ALFF and ReHo were observed in auditory and language-related cortex. Increased ALFF and ReHo were observed in vision related cortex, which suggest that hearing and language function were impaired and vision function was enhanced due to the loss of hearing. ALFF of left Brodmann area 45 (BA45) was negatively correlated with deaf duration in infants with CSSHL. ALFF of right BA39 was positively correlated with deaf duration in infants with CSSHL. In conclusion, ALFF and ReHo can reflect the abnormal brain function in language, auditory, and visual information processing in infants with CSSHL. This demonstrates that the development of auditory, language, and vision processing function has been affected by congenital severe sensorineural hearing loss before 4 years of age.
authors.affiliation: Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, China.
authors.forename: Shuang
authors.identifier: 0000-0003-1626-6383
authors.initials: S
authors.lastname: Xia
authors.affiliation: Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: TianBin
authors.identifier: 0000-0002-9646-6539
authors.initials: T
authors.lastname: Song
authors.affiliation: Department of Ultrasound, Aerospace Central Hospital, Beijing 100049, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Che
authors.affiliation: School of Law and Politics, Tianjin University of Technology, Tianjin 300384, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chai
authors.affiliation: Department of Radiology, Tianjin Third Central Hospital, Tianjin 300172, China.
authors.forename: Meizhu
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Shen
mesh_terms: D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002675:Child, Preschool; D016292:Procedural Sedation; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000151:congenital / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D009778:Occipital Lobe / Q000503:physiopathology; D013702:Temporal Lobe / Q000503:physiopathology