title: The effect of multiple thin-film coatings of protein loaded sol-gel on total multi-electrode array thickness.
abstract: Tetramethyl orthosilicate shows promise as a thin-film delivery vehicle for multi-electrode arrays for drug release and electrical performance; however, its effect upon device footprint has yet to be assessed. Using a previously established silicon wafer chip model, the thickness of one, two, and four protein doped coatings of sol-gel were analyzed via profilometry. Coating thickness was found to be 0.4μm, 1.1μm and 2.2μm on each side of the device. This addition to a native MEA is minimal when compared to other drug delivery paradigms currently associated with neural implants.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: McDermott
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Otto
mesh_terms: D020099:Coated Materials, Biocompatible; D016503:Drug Delivery Systems; D004566:Electrodes; D004867:Equipment Design; D017646:Organosilicon Compounds; D044367:Phase Transition; D011506:Proteins / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D017646:Organosilicon Compounds; D011506:Proteins; C500739:tetramethyl orthosilicate