title: An account of fungal 14-3-3 proteins.
abstract: 14-3-3s are a group of relatively low molecular weight, acidic, dimeric, protein(s) conserved from single-celled yeast to multicellular vertebrates including humans. Despite lacking catalytic activity, these proteins have been shown to be involved in multiple cellular processes. Apart from their role in normal cellular physiology, recently these proteins have been implicated in various medical consequences. In this present review, fungal 14-3-3 protein localization, interactions, transcription, regulation, their role in the diverse cellular process including DNA duplication, cell cycle, protein trafficking or secretion, apoptosis, autophagy, cell viability under stress, gene expression, spindle positioning, role in carbon metabolism have been discussed. In the end, I also highlighted various roles of yeasts 14-3-3 proteins in tabular form. Thus this review with primary emphasis on yeast will help in appreciating the significance of 14-3-3 proteins in cell physiology.
authors.affiliation: Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, Maharashtra, India. Electronic address: raj86tau@gmail.com.
authors.forename: Ravinder
authors.initials: R
authors.lastname: Kumar
mesh_terms: D048948:14-3-3 Proteins / Q000378:metabolism*; D000818:Animals; D005656:Fungal Proteins / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism*; D006801:Humans; D040901:Proteomics
chemical_list: D048948:14-3-3 Proteins; D005656:Fungal Proteins
keywords: 14-3-3; Bmh1/2; Cell cycle; Fungus; Proteomics; Stress