title: [Ventilator-associated pneumonia among premature infants <34 weeks' gestational age in neonatal intensive care unit in China: a multicenter study].
abstract: Objective:To investigate the incidence and pathogen distribution of ventilator-associated pneumonia (VAP) among preterm infants admitted to level Ⅲ neonatal intensive care units (NICU) in China.Method:A prospective study was conducted in 25 level Ⅲ NICU, enrolling all preterm infants <34 weeks gestational age admitted to the participating NICU within the first 7 days of life from May 2015 to April 2016. Chi-square test,ttest and Mann-WhitneyUtest were used for statistical analysis.Result:A total of 7 918 patients were enrolled, within whom 4 623(58.4%) were males. The birth weight was (1 639±415) g and the gestational age was (31.4±2.0) weeks; 4 654(58.8%) infants required non-invasive mechanical ventilation and 2 154(27.2%) required intubation. Of all the mechanically ventilated patients, VAP occurred in 95 patients. The overall VAP rate was 7.0 episodes per 1 000 ventilator days, varying from 0 to 34.4 episodes per 1 000 ventilator days in different centers. The incidence of VAP was 9.6 and 6.0 per 1 000 ventilator days in children's hospitals and maternity-infant hospitals respectively, without significant differences (t=1.002,P=0.327).Gram-negative bacilli(76 strains, 91.6%) were the primary VAP microorganisms, mainlyAcinetobacter baumannii(24 strains, 28.9%),Klebsiella pneumonia(23 strains, 27.7%), andPseudomonas aeruginosa(10 strains, 12.0%).Conclusion:The incidence of VAP in China is similar to that in developed counties, with substantial variability in different NICU settings. More efforts are needed to monitor and evaluate the preventable factors associated with VAP and conduct interventions that could effectively reduce the occurrence of VAP.
authors.affiliation: *Department of Neonatology, Children's Hospital of Fudan University, Shanghai 201102, China.
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mesh_terms: D001724:Birth Weight; D002681:China; D005260:Female; D005865:Gestational Age; D006090:Gram-Negative Bacteria; D006776:Hospitals, Pediatric; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D007711:Klebsiella pneumoniae; D008297:Male; D053717:Pneumonia, Ventilator-Associated; D011446:Prospective Studies; D012122:Ventilators, Mechanical
keywords: Infant, newborn; Multicenter study; Pathogen; Pneumonia, ventilator-associated