title: Gold(I)-Catalyzed Intramolecular Hydroamination of Unactivated Terminal and Internal Alkenes with 2-Pyridones.
abstract: The cationic gold phosphine complex [(P1)Au(NCMe)]+SbF6-[P1 = P(t-Bu)2o-biphenyl; 2] catalyzes the intramolecular hydroamination of 6-alkenyl-2-pyridones to form 1,6-carboannulated 2-pyridones in high yield. The hydroamination of 6-(γ-alkenyl)-2-pyridones was effective for monosubstituted and 1,1- and 1,2-disubstituted aliphatic alkenes, and the method was likewise effective for the hydroamination of 6-(δ-alkenyl)-2-pyridones. Spectroscopic analysis of mixtures of 6-(3-butenyl)-2-pyridone, (P1)AuCl, and AgSbF6established the N-bound 2-hydroxypyridine complex [(P1)Au(NC6H3-2-OH-6-CH2CH2CH═CH2)]+SbF6-as the catalyst resting state.
authors.affiliation: French Family Science Center, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Jacob C
authors.initials: JC
authors.lastname: Timmerman
authors.affiliation: French Family Science Center, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Laulhé
authors.affiliation: French Family Science Center, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Ross A
authors.identifier: 0000-0002-5349-8477
authors.initials: RA
authors.lastname: Widenhoefer