title: Unveiling the Role of Senescence-Induced Cellular Plasticity.
abstract: Mice expressing Yamanaka factors develop teratomas containing iPSCs, suggesting that somatic cells are reprogrammable in vivo. Recent studies in Cell, Science, and this issue of Cell Stem Cell (Ocampo et al., 2016; Mosteiro et al., 2016; Chiche et al., 2017, respectively) report crosstalk between reprogramming and senescence, providing insights on cellular plasticity in multicellular organisms.
authors.affiliation: Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
authors.forename: Jumpei
authors.initials: J
authors.lastname: Taguchi
authors.affiliation: Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan. Electronic address: y-yamada@cira.kyoto-u.ac.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000818:Animals; D000066670:Cell Plasticity; D065150:Cellular Reprogramming; D057026:Induced Pluripotent Stem Cells; D051379:Mice; D013724:Teratoma