title: Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille.
abstract: OBJECTIVE
  To assess the antinociceptive and anti-inflammatory properties of the aqueous extract of Armadillidium vulgare (AV).
  
  
  METHODS
  The antinociceptive effect of AV (400, 600 and 800 mg/kg) was investigated in mice using the acetic acid-induced writhing, formalin-induced nociceptive, and hot plate tests. Phlogogen-induced paw edema using carrageenan, dextran, or compound 48/80 as phlogogen was used as inflammatory models to evaluate AV's anti-inflammatory effect. Additionally, the bioactive substances glucosamine (GLcN) and taurine in AV were determined using high-performance liquid chromatography.
  
  
  RESULTS
  Oral treatment of the mice with AV (600 and 800 mg/kg) significantly reduced the number of writhes in the acetic acid-induced writhing test (P<0.01) but not the hot plate test (P>0.05). All doses tested significantly inhibited paw-withdrawal during the second phase of the formalin-induced nociceptive model (P<0.01). AV demonstrated a strong anti-inflammatory effect in all those inflammatory models (P<0.05).
  
  
  CONCLUSIONS
  AV has antinociceptive and anti-inflammatory effects, providing scientific evidence of the efficacy of its traditional use in pain treatment. Furthermore, GLcN and taurine contribute, at least in part, to the anti-inflammatory activity of AV.
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Shen-Shen
authors.initials: SS
authors.lastname: Guo
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Meng-Yue
authors.initials: MY
authors.lastname: Ren
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Song
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wei
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China. ljb@smu.edu.cn.|Guangdong Province Key Laboratory of Chinese Medicine Pharmaceutics, Southern Medical University, Guangzhou, 510515, China. ljb@smu.edu.cn.
authors.forename: Jia-Bo
authors.initials: JB
authors.lastname: Luo
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004487:Edema / Q000188:drug therapy; D005260:Female; D007249:Inflammation / Q000188:drug therapy; D033321:Isopoda / Q000737:chemistry*; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D014867:Water / Q000737:chemistry
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D014867:Water
keywords: Armadillidium vulgare; glucosamine; inflammation; medicinal animal; nociception