title: Prospective comparison of outcome after treatment for triple-negative and non-triple-negative breast cancer.
abstract: BACKGROUND
  Triple-negative breast cancers (TNBC) are associated with a poor prognosis owing to an aggressive phenotype. We aimed to carry out a prospective study comparing management strategies and response to therapy in TNBC and non-TNBC patients.
  
  
  METHODS
  Data were obtained from a prospectively maintained database of patients treated for breast cancer.
  
  
  RESULTS
  A total of 142 TNBC and 142 age-, stage- and NPI-matched non-TNBC patients were treated. The difference in overall survival between the 2 groups was statistically significant (77% of TNBC patients alive at a mean follow-up of 32 months, versus 92% of non-TNBC patients at a mean follow-up of 38 months, P = 0.0 Log rank test). This survival difference was found to be independent of NPI (P = 0.0 Log rank test). Locoregional recurrence rates were similar between TNBC patients who were treated with wide local excision versus mastectomy (P = 0.449 Log rank test). A significant difference in survival was noted between TNBC patients who responded differentially to neoadjuvant chemotherapy (P = 0.035 Log rank test).
  
  
  CONCLUSIONS
  Patients with TNBC have adverse outcomes despite aggressive treatment. The development of effective targeted therapies is essential for this breast cancer subtype.
authors.affiliation: Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Ireland. Electronic address: doireann.joyce@gmail.com.
authors.forename: D P
authors.initials: DP
authors.lastname: Joyce
authors.affiliation: Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Ireland.
authors.forename: D
authors.initials: D
authors.lastname: Murphy
authors.affiliation: Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Ireland.
authors.forename: A J
authors.initials: AJ
authors.lastname: Lowery
authors.affiliation: Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Curran
authors.affiliation: Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Ireland.
authors.forename: K
authors.initials: K
authors.lastname: Barry
authors.affiliation: Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Malone
authors.affiliation: Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Ireland.
authors.forename: R
authors.initials: R
authors.lastname: McLaughlin
authors.affiliation: Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Ireland.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kerin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008408:Mastectomy / Q000379:methods*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D064726:Triple Negative Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D055815:Young Adult
keywords: Breast cancer; Non-triple-negative; Triple-negative