title: Intramolecular macrolactonization, photophysical and biological studies of new class of polycyclic pyrrole derivatives.
abstract: Herein, we report an efficient synthesis of N-substituted pyrrole derivatives and their application to construct macrocyclic oxazocinone via a two-component coupling reaction followed by base mediated intramolecular cyclization. This methodology provides an easy two-step approach to constitute a library of fused pyrrolo-oxazocinone derivatives in good yields under mild reaction conditions. The present methodology offers an easy access to the synthesis of a library of fluorescent pyrole derivatives. Among them, tert-butyl 2-(2-(3-hydroxypropyl)-7-methoxy-4,5-dihydro-2H-benzo[e]isoindol-1-yl)acetate has been employed in bio-analytical imaging which shows efficient cellular internalization along with no obvious cellular toxicity.
authors.affiliation: Department of Chemistry, Bidhannagar College, Kolkata 700064, India. chemshubha@gmail.com.
authors.forename: Suresh Kumar
authors.initials: SK
authors.lastname: Mondal
authors.forename: Arabinda
authors.initials: A
authors.lastname: Mandal
authors.forename: Susanta Kumar
authors.initials: SK
authors.lastname: Manna
authors.forename: Sk Asraf
authors.initials: SA
authors.lastname: Ali
authors.forename: Maidul
authors.initials: M
authors.lastname: Hossain
authors.forename: Vangala
authors.initials: V
authors.lastname: Venugopal
authors.forename: Avijit
authors.initials: A
authors.lastname: Jana
authors.forename: Shubhankar
authors.initials: S
authors.lastname: Samanta