title: Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containingPunica granatumseed oil andCroton lechleriresin extract.
abstract: Striae distensae are a frequent skin condition associated with pregnancy, weight change or lack of skin elasticity. The aim of this research was to obtain a topical product containing herbal active ingredients with documented antioxidant and anti-inflammatory activity (Punica granatumseed oil andCroton lechleriresin extract) and demonstrate its positive effect on prevention and treatment of striae distensae. First, the cream base formulation was optimized through experimental design. Secondly, the cream containing the two active ingredients was investigated in an interventional nonrandomized clinical trial. The clinical outcome was assessed through biophysical parameters and ultrasonographic evaluation. The state of the skin was evaluated by biophysical measurements and ultrasonography at the beginning of the study and after 3 and 6 weeks. The experimental design was successfully used to set the best ranges for the technological and formulation factors to obtain a cosmetic formulation with optimal characteristics. The study of clinical efficacy on the optimal formulation revealed an increase in the dermis thickness, hydration and elasticity values in both groups after 6 weeks of cream application. The new oil-in-water cream containingP. granatumseed oil andC. lechleriresin extract can be helpful in the prevention or improving of skin changes associated with striae.
authors.affiliation: Department of Dermatopharmacy and Cosmetics.
authors.forename: Cătălina
authors.initials: C
authors.lastname: Bogdan
authors.affiliation: Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Haţieganu, Cluj-Napoca, Romania.
authors.forename: Sonia
authors.initials: S
authors.lastname: Iurian
authors.affiliation: Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Haţieganu, Cluj-Napoca, Romania.
authors.forename: Ioan
authors.initials: I
authors.lastname: Tomuta
authors.affiliation: Department of Dermatopharmacy and Cosmetics.
authors.forename: Mirela
authors.initials: M
authors.lastname: Moldovan
mesh_terms: D000328:Adult; D003257:Consumer Product Safety; D003358:Cosmetics / Q000737:chemistry*; D029802:Croton / Q000737:chemistry*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D029561:Lythraceae / Q000737:chemistry*; D008875:Middle Aged; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D012867:Skin / Q000187:drug effects*; D057896:Striae Distensae / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D003358:Cosmetics; D010936:Plant Extracts; D010938:Plant Oils
keywords: design of experiments; oil-in-water emulsion; stretch marks; texture analysis; ultrasonography