title: Developing and validating a theoretical measure of modifiable influences on hormonal therapy medication taking behaviour in women with breast cancer.
abstract: OBJECTIVE
  Taking adjuvant hormonal therapy for 5-10 years is recommended to prevent breast cancer recurrence in those with oestrogen positive disease. Despite proven clinical efficacy many women do not take their hormonal therapy as prescribed. This study reports the development and initial validation of a questionnaire measuring the behavioural determinants of hormonal therapy medication taking behaviour (MTB) based on the theoretical domains framework (TDF).
  
  
  METHODS
  Women with Stage I-III breast cancer (N = 223) completed the questionnaire based on the TDF. The TDF is an integrative framework consisting of 14 domains of behaviour change determinants to inform intervention design.
  
  
  METHODS
  Items were developed from previous research, in-depth patient interviews and consultation with health professionals. Confirmatory factor analysis (CFA) was undertaken to generate the model of best fit.
  
  
  RESULTS
  The final questionnaire consisted of eight domains and CFA produced a reasonable fit (χ2(810) = 942, p < .001; RMSEA = .03; CFI = .93 and WRMR = .91) as well as internal consistency (r = .16 to .64). There were adequate levels of discriminant validity for the majority of the domains.
  
  
  CONCLUSIONS
  A TDF-based measure of the behavioural determinants of MTB was developed. Further research is needed to confirm the reliability and validity of this measure.
authors.affiliation: a Division of Population Health Sciences , Royal College of Surgeons in Ireland , Dublin , Ireland.
authors.forename: Caitriona
authors.initials: C
authors.lastname: Cahir
authors.affiliation: b Division of Psychology , University of Stirling , Stirling , Scotland.
authors.forename: Stephan U
authors.initials: SU
authors.lastname: Dombrowski
authors.affiliation: c Medical Oncology, St James's Hospital, Ireland and Trinity College Dublin , Dublin , Ireland.
authors.forename: M John
authors.initials: MJ
authors.lastname: Kennedy
authors.affiliation: d Institute of Health and Society, Newcastle University , Newcastle , UK.
authors.forename: Linda
authors.initials: L
authors.lastname: Sharp
authors.affiliation: a Division of Population Health Sciences , Royal College of Surgeons in Ireland , Dublin , Ireland.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Bennett
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009367:Neoplasm Staging; D011582:Psychological Theory; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D016903:Drug Monitoring
chemical_list: D018931:Antineoplastic Agents, Hormonal
keywords: adherence; breast cancer; hormonal therapy; medication taking behaviour; theoretical domains framework