title: Analysis of CT features and quantitative texture analysis in patients with lung adenocarcinoma: a correlation with EGFR mutations and survival rates.
abstract: OBJECTIVE
  To investigate the correlation between conventional computed tomography (CT) features, quantitative texture analysis (QTA), epidermal growth factor receptor (EGFR) mutations, and survival rates in patients with lung adenocarcinoma.
  
  
  METHODS
  Sixty-eight patients were evaluated for conventional CT features and QTA in this retrospective study. A multiple logistic regression analysis and receiver operating characteristics (ROC) curve analysis versus death and EGFR status was performed for CT features and QTA in order to assess correlation between CT features, QTA, EGFR mutations, and survival rates. A p-value <0.05 was regarded to indicate a statistically significant association.
  
  
  RESULTS
  An EGFR mutation was identified in 26/68 tumours (38.2%). A negative association was found between EGFR mutation and emphysema (p < 0.0001) whereas a positive correlation was found with necrosis (p=0.017), air bronchogram (p=0.0304), and locoregional infiltration (p=0.0018). Mean, standard deviation, and skewness were found to have significant correlation with EGFR mutation (p=0.0001; p=0.0001; p=0.0459; Fig 3). The only parameter correlated with the event death was entropy (r=0.2708; p=0.0329).
  
  
  CONCLUSIONS
  Both qualitative and quantitative analysis disclosed potential associations between CT features and QTA parameters, EGFR mutations and prognosis; these correlations need to be confirmed in larger studies to be used as imaging biomarkers in the management of patients affected by lung adenocarcinoma.
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences - Radiology, "Sapienza" University of Rome, Rome, Italy. Electronic address: beatrice.sacconi@fastwebnet.it.
authors.forename: B
authors.initials: B
authors.lastname: Sacconi
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences - Radiology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Anzidei
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences - Radiology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Leonardi
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences - Radiology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Boni
authors.affiliation: Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari - Polo di Monserrato, Monserrato, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Saba
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences - Radiology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Scipione
authors.affiliation: Department of Thoracic Surgery, "Sapienza" University of Rome, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Anile
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences - Radiology, "Sapienza" University of Rome Polo Pontino, Latina, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rengo
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences - Oncology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Longo
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences - Radiology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bezzi
authors.affiliation: Department of Thoracic Surgery, "Sapienza" University of Rome, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Venuta
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences - Radiology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Napoli
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences - Radiology, "Sapienza" University of Rome Polo Pontino, Latina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Laghi
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences - Radiology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Catalano
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000235:genetics* / Q000401:mortality; D000077192:Adenocarcinoma of Lung; D000368:Aged; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors