title: Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links?
abstract: The goal of this review is to delineate the following: (1) the primary means of inorganic arsenic (iAs) exposure for human populations, (2) the adverse public health outcomes associated with chronic iAs exposure, (3) the pathophysiological connection between arsenic and type 2 diabetes (T2D), and (4) the incipient evidence for microRNAs as candidate mechanistic links between iAs exposure and T2D.
  
  
  
  Exposure to iAs in animal models has been associated with the dysfunction of several different cell types and tissues, including liver and pancreatic islets. Many microRNAs that have been identified as responsive to iAs exposure under in vitro and/or in vivo conditions have also been shown in independent studies to regulate processes that underlie T2D etiology, such as glucose-stimulated insulin secretion from pancreatic beta cells. Defects in insulin secretion could be, in part, associated with aberrant microRNA expression and activity. Additional in vivo studies need to be performed with standardized concentrations and durations of arsenic exposure in order to evaluate rigorously microRNAs as molecular drivers of iAs-associated diabetes.
authors.affiliation: Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.|Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
authors.forename: Rowan
authors.initials: R
authors.lastname: Beck
authors.affiliation: Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Styblo
authors.affiliation: Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. praveen_sethupathy@med.unc.edu.|Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. praveen_sethupathy@med.unc.edu.
authors.forename: Praveen
authors.initials: P
authors.lastname: Sethupathy
mesh_terms: D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism; D035683:MicroRNAs / Q000502:physiology*
chemical_list: D007328:Insulin; D035683:MicroRNAs; D001151:Arsenic
keywords: Arsenic; Diabetes; Insulin; Metabolism; MicroRNAs; β-Cell