title: Duration of red blood cell storage and inflammatory marker generation.
abstract: Red blood cell (RBC) transfusion is a life-saving treatment for several pathologies. RBCs for transfusion are stored refrigerated in a preservative solution, which extends their shelf-life for up to 42 days. During storage, the RBCs endure abundant physicochemical changes, named RBC storage lesions, which affect the overall quality standard, the functional integrity and in vivo survival of the transfused RBCs. Some of the changes occurring in the early stages of the storage period (for approximately two weeks) are reversible but become irreversible later on as the storage is extended. In this review, we aim to decipher the duration of RBC storage and inflammatory marker generation. This phenomenon is included as one of the causes of transfusion-related immunomodulation (TRIM), an emerging concept developed to potentially elucidate numerous clinical observations that suggest that RBC transfusion is associated with increased inflammatory events or effects with clinical consequence.
authors.affiliation: GIMAP-EA3064, Lyon University, Saint Etienne, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Sut
authors.affiliation: GIMAP-EA3064, Lyon University, Saint Etienne, France.
authors.forename: Sofiane
authors.initials: S
authors.lastname: Tariket
authors.affiliation: Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Ming Li
authors.initials: ML
authors.lastname: Chou
authors.affiliation: GIMAP-EA3064, Lyon University, Saint Etienne, France.|Institut National de Transfusion Sanguine (INTS), Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Garraud
authors.affiliation: GIMAP-EA3064, Lyon University, Saint Etienne, France.|French Blood Establishment (EFS) Rhône-Alpes-Auvergne, Saint-Etienne, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Laradi
authors.affiliation: GIMAP-EA3064, Lyon University, Saint Etienne, France.
authors.forename: Hind
authors.initials: H
authors.lastname: Hamzeh-Cognasse
authors.affiliation: International Consultancy in Blood Components Quality/Safety, Audit/Inspection and DDR Strategy, London, United Kingdom.
authors.forename: Jerard
authors.initials: J
authors.lastname: Seghatchian
authors.affiliation: Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.|International PhD Programme in Biomedical Engineering and Translational Therapies, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
authors.forename: Thierry
authors.initials: T
authors.lastname: Burnouf
authors.affiliation: GIMAP-EA3064, Lyon University, Saint Etienne, France.|French Blood Establishment (EFS) Rhône-Alpes-Auvergne, Saint-Etienne, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Cognasse
mesh_terms: D015415:Biomarkers; D001793:Blood Preservation / Q000009:adverse effects* / Q000379:methods; D017707:Erythrocyte Transfusion / Q000009:adverse effects* / Q000379:methods; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D056747:Immunomodulation; D018836:Inflammation Mediators / Q000378:metabolism*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators