title: Transdiaphragmatic pressure and neural respiratory drive measured during inspiratory muscle training in stable patients with chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  Inspiratory muscle training (IMT) is a rehabilitation therapy for stable patients with COPD. However, its therapeutic effect remains undefined due to the unclear nature of diaphragmatic mobilization during IMT. Diaphragmatic mobilization, represented by transdiaphragmatic pressure (Pdi), and neural respiratory drive, expressed as the corrected root mean square (RMS) of the diaphragmatic electromyogram (EMGdi), both provide vital information to select the proper IMT device and loads in COPD, therefore contributing to the curative effect of IMT. Pdi and RMS of EMGdi (RMSdi%) were measured and compared during inspiratory resistive training and threshold load training in stable patients with COPD.
  
  
  METHODS
  Pdi and neural respiratory drive were measured continuously during inspiratory resistive training and threshold load training in 12 stable patients with COPD (forced expiratory volume in 1 s ± SD was 26.1%±10.2% predicted).
  
  
  RESULTS
  Pdi was significantly higher during high-intensity threshold load training (91.46±17.24 cmH2O) than during inspiratory resistive training (27.24±6.13 cmH2O) in stable patients with COPD, withP<0.01 for each. Significant difference was also found in RMSdi% between high-intensity threshold load training and inspiratory resistive training (69.98%±16.78% vs 17.26%±14.65%,P<0.01).
  
  
  CONCLUSIONS
  We concluded that threshold load training shows greater mobilization of Pdi and neural respiratory drive than inspiratory resistive training in stable patients with COPD.
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou.
authors.forename: Weiliang
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Guizhou Medical University, Guizhou, People's Republic of China.
authors.forename: Xianming
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou.
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou.
authors.forename: Yonger
authors.initials: Y
authors.lastname: Ou
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou.
authors.forename: Lili
authors.initials: L
authors.lastname: Guan
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou.
authors.forename: Bingpeng
authors.initials: B
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou.
authors.forename: Luqian
authors.initials: L
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou.
authors.forename: Rongchang
authors.initials: R
authors.lastname: Chen
mesh_terms: D000368:Aged; D001945:Breathing Exercises / Q000295:instrumentation / Q000379:methods; D002681:China; D003430:Cross-Sectional Studies; D003964:Diaphragm / Q000294:innervation*; D004576:Electromyography; D004867:Equipment Design; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D001239:Inhalation; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011312:Pressure; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000503:physiopathology / Q000534:rehabilitation*; D055070:Resistance Training / Q000295:instrumentation / Q000379:methods; D012125:Respiratory Center / Q000503:physiopathology*; D016896:Treatment Outcome
keywords: diaphragmatic electromyogram; inspiratory resistive training; inspiratory threshold load training; pulmonary rehabilitation; respiratory physiological detection