title: Nanoparticles based on crocin loaded chitosan-alginate biopolymers: Antioxidant activities, bioavailability and anticancer properties.
abstract: Crocin, a water-soluble carotenoid in saffron, is a highly bioactive compound with limited use due to instability to pH variations, heat and oxidative stress, rapid absorption and low bioavailability. In this study, chitosan-alginate nanoparticles, considered as a new vehicle for crocin to improve properties in terms of antioxidant activity, bioavailability and anticancer activity. The swelling of crocin loaded nanoparticles was pH-dependent so that the highest swelling ratio (16g/g) was observed in acidic condition (pH=1.2) after 24h. The antioxidant activity of the crocin loaded nanoparticles was the same effective as pure crocin on DPPH free radical scavenging and ferric reducing ability of plasma (FRAP). In vitro crocin release profile from composite nanoparticles was investigated under simulated physiological conditions during incubation time. The experimental reports collected in this study strongly indicate that nanoparticles loaded with crocin could be the prospective candidates for the future anti-cancer therapeutics that deserve additional investigations.
authors.affiliation: Department of Food science, Engineering and Technology, Faculty of Agricultural Engineering and Technology, University of Tehran, Karaj, Iran; Department of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Rahaiee
authors.affiliation: Department of Microbial Biotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran. Electronic address: hashemim@abrii.ac.ir.
authors.forename: Maryam
authors.initials: M
authors.lastname: Hashemi
authors.affiliation: Biotechnology Group, Department of Chemical Engineering, Tarbiat Modarres University, Tehran, Iran.
authors.forename: Seyed Abbas
authors.initials: SA
authors.lastname: Shojaosadati
authors.affiliation: Department of Food science, Engineering and Technology, Faculty of Agricultural Engineering and Technology, University of Tehran, Karaj, Iran.
authors.forename: Sohrab
authors.initials: S
authors.lastname: Moini
authors.affiliation: Department of Food science, Engineering and Technology, Faculty of Agricultural Engineering and Technology, University of Tehran, Karaj, Iran.
authors.forename: Seyed Hadi
authors.initials: SH
authors.lastname: Razavi
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001682:Biological Availability; D002338:Carotenoids / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology*; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D000464:Alginates; D000970:Antineoplastic Agents; D000975:Antioxidants; D004337:Drug Carriers; D006603:Hexuronic Acids; D002338:Carotenoids; C029036:crocin; D020723:Glucuronic Acid; D048271:Chitosan
keywords: Anticancer activity; Antioxidant activity; Controlled release; Crocin; Nanoparticles