title: Periostin is essential for periodontal ligament remodeling during orthodontic treatment.
abstract: Orthodontic tooth movement is a process stimulated and maintained by external tensile stress; periodontal ligament remodeling serves an important role during this process. However, the function and underlying mechanism of periostin (PN) during orthodontic periodontal ligament remodeling remain unclear. The present study established in vitro and in vivo models of orthodontic treatment to investigate the expression levels of PN under conditions of external tensile stress load. These results indicated that tensile stress load increased the expression levels of PN in mouse peridontal ligaments and human periodontal ligament cells (hPDLCs), during orthodontic tooth movement. Furthermore, the present study demonstrated that the expression levels of PN were regulated by transforming grown factor β, and that PN promotes type I collagen and α‑smooth muscle actin expression levels in hPDLCs. Therefore, PN may be essential for periodontal ligament remodeling during orthodontic treatment, and therefore may represent a potential therapeutic target.
authors.affiliation: Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Hui-Yong
authors.initials: HY
authors.lastname: Xu
authors.affiliation: Department of Stomatology, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Er-Min
authors.initials: EM
authors.lastname: Nie
authors.affiliation: Department of Stomatology, The People's Hospital of Jiaozuo, Jiaozuo, Henan 454002, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Deng
authors.affiliation: Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Ling-Zhi
authors.initials: LZ
authors.lastname: Lai
authors.affiliation: Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Feng-Yang
authors.initials: FY
authors.lastname: Sun
authors.affiliation: Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Tian
authors.affiliation: Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Fu-Chun
authors.initials: FC
authors.lastname: Fang
authors.affiliation: Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Ya-Guang
authors.initials: YG
authors.lastname: Zou
authors.affiliation: Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Bu-Ling
authors.initials: BL
authors.lastname: Wu
authors.affiliation: Guangdong Provincial Medical Biomechanical Key Laboratory, Department of Anatomy, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ou-Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D002478:Cells, Cultured; D002648:Child; D024042:Collagen Type I / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008810:Mice, Inbred C57BL; D010513:Periodontal Ligament / Q000166:cytology* / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D013314:Stress, Mechanical; D014087:Tooth Movement Techniques; D016211:Transforming Growth Factor alpha / Q000378:metabolism; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015815:Cell Adhesion Molecules; D024042:Collagen Type I; C512835:POSTN protein, human; D012333:RNA, Messenger; D016211:Transforming Growth Factor alpha