title: On spray drying of oxidized corn starch cross-linked gelatin microcapsules for drug release.
abstract: Spray-dried gelatin/oxidized corn starch (G/OCS) microcapsules were produced for drug release application. The prepared microcapsules were characterized through a scanning electron microscope (SEM) picture and thermogravimetric analysis (TGA). The swelling characteristics of the G/OCS microcapsules and release properties of vitamin C were then investigated. The results from structural analysis indicated that the presence of miscibility and compatibility between oxidized corn starch and gelatin, and exhibits high thermal stability up to 326°C. The swelling of G/OCS microcapsules increased with increasing pH and reduced with decreasing ionic strength, attributed to the cross-linking between gelatin and oxidized corn starch, ionization of functional groups. Vitamin C release characteristic revealed controlled release behavior in the first 3h of contact with an aqueous medium. This release behavior was independent of the swelling behavior indicating the potential of the encapsulating matrix to produce controlled release across a spectrum of pH environment.
authors.affiliation: National Engineering Laboratory for Clean Technology Leather Manufacture, Sichuan University, Chengdu, Sichuan 610065, China.
authors.forename: Xugang
authors.initials: X
authors.lastname: Dang
authors.affiliation: National Engineering Laboratory for Clean Technology Leather Manufacture, Sichuan University, Chengdu, Sichuan 610065, China.
authors.forename: Mao
authors.initials: M
authors.lastname: Yang
authors.affiliation: National Engineering Laboratory for Clean Technology Leather Manufacture, Sichuan University, Chengdu, Sichuan 610065, China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Shan
authors.affiliation: Department of Chemical Engineering, Monash University, VIC 3800, Australia.
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Mansouri
authors.affiliation: School of Applied Science, RMIT University, 124 La Trobe St, Melbourne, VIC 3001, Australia.
authors.forename: Bee K
authors.initials: BK
authors.lastname: May
authors.affiliation: Department of Chemical Engineering, Monash University, VIC 3800, Australia; School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Material Science, Soochow University, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Chen
authors.affiliation: National Engineering Laboratory for Clean Technology Leather Manufacture, Sichuan University, Chengdu, Sichuan 610065, China; Department of Chemical Engineering, Monash University, VIC 3800, Australia. Electronic address: leather2088@sina.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Chemical Engineering, Monash University, VIC 3800, Australia. Electronic address: meng.woo@monash.edu.
authors.forename: Meng Wai
authors.initials: MW
authors.lastname: Woo
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry* / Q000378:metabolism; D002214:Capsules / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005780:Gelatin / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D013213:Starch / Q000737:chemistry*; D013818:Thermogravimetry; D003313:Zea mays / Q000378:metabolism*
chemical_list: D002214:Capsules; D004337:Drug Carriers; D005780:Gelatin; D013213:Starch; D001205:Ascorbic Acid
keywords: Gelatin; Microcapsules; Oxidized corn starch