title: Endocrinology and Pediatric Exercise Science-2016.
abstract: The Pediatric Exercise Science Year That Was section aims to highlight the most important (to the author's opinion) manuscripts that were published in 2016 in the field of endocrinology and pediatric exercise science. This year's selection includes studies showing that 1) Induction of T4 to T3 conversion by type 2 deiodinase following aerobic exercise in skeletal muscles was associated with concomitant increase in peroxisome proliferatoractivated receptor-γ coactivator-1α, and mitochondrial oxidative capacity and therefore plays an important mechanistic role in the muscle adaptation to exercise training. 2) Hypothyroidism in fetal and early postnatal life was associated with impaired spatial learning and memory and with reduced hippocampal brain-derived neurotrophic factor in male and female rat pups. Forced (treadmill) and voluntary (wheel) exercise alleviated all these biochemical and neuro-cognitive deficits. 3) The relationship between different exercise intensities and carbohydrate requirements to maintain euglycemia at basal insulin levels among adolescent and young adults with Type 1 diabetes are nonlinear but rather inverted- U with no exogenous glucose required to maintain stable glucose level at high-intensity exercise (80%). The implication of these studies to the pediatric population, their importance and the new research avenues that were opened by these studies is emphasized.
authors.affiliation: 1 Tel-Aviv University.
authors.forename: Alon
authors.initials: A
authors.lastname: Eliakim
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D004703:Endocrine System / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D005947:Glucose / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D007037:Hypothyroidism / Q000503:physiopathology; D007453:Iodide Peroxidase / Q000502:physiology; D008297:Male; D008568:Memory; D051379:Mice; D008928:Mitochondria / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D065853:Spatial Learning; D014284:Triiodothyronine / Q000502:physiology; D055815:Young Adult; D000097564:Iodothyronine Deiodinase Type II
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D005947:Glucose; D007453:Iodide Peroxidase; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014284:Triiodothyronine; D000097564:Iodothyronine Deiodinase Type II; C501429:Ppargc1a protein, rat