title: [New aspects in the development of sunscreening agents].
abstract: Sunlight is indispensable for life. Skin aging is determined not only by genetic factors but also by the influence of solar radiation which in all its spectral regions induces free radicals in the human skin. Below a critical concentration, free radicals are important for signaling processes in the human body. Exceeding a critical threshold value (FRTV), however, free radicals lead to cellular damage which, in turn, can induce skin aging, immunosuppression and even skin cancer. Recently it could be shown that 50% of the free radicals induced in the human skin by solar radiation were caused by the visible and infrared spectral regions. Taking into consideration that people who use sunscreen stay considerably longer in the sun than unprotected people, their skin could be exposed to free radical formation in the visible and infrared spectral regions, which far exceeds the critical threshold. Filter substances like those used in sunscreens for skin protection in the ultraviolet region are not available for the visible and infrared spectral regions. Using the natural protection mechanisms of the human skin as examples, however, the protective effect of sunscreens can be considerably enhanced by the addition of scattering and reflective pigments, such as titanium dioxide, as well as of antioxidants which neutralize the free radicals. Currently the focus of sunscreen development is shifting from mere UV protection to protection covering the entire solar spectrum.
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland. juergen.lademann@charite.de.
authors.forename: J
authors.initials: J
authors.lastname: Lademann
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
authors.forename: M C
authors.initials: MC
authors.lastname: Meinke
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Schanzer
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Albrecht
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
authors.forename: L
authors.initials: L
authors.lastname: Zastrow
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D003880:Dermatology / Q000639:trends; D019317:Evidence-Based Medicine; D006801:Humans; D011835:Radiation Protection / Q000379:methods*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000737:chemistry; D012871:Skin Diseases / Q000209:etiology* / Q000517:prevention & control*; D012993:Solar Energy; D013472:Sunlight / Q000009:adverse effects*; D013473:Sunscreening Agents / Q000008:administration & dosage* / Q000737:chemistry; D014025:Titanium / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D011837:Radiation-Protective Agents; D013473:Sunscreening Agents; C009495:titanium dioxide; D014025:Titanium
keywords: Free radicals; Immunosuppression; Skin aging; Skin neoplasms; Sunlight