title: Lipid and lipoprotein abnormalities in acute lymphoblastic leukemia survivors.
abstract: Survivors of acute lymphoblastic leukemia (ALL), the most common cancer in children, are at increased risk of developing late cardiometabolic conditions. However, the mechanisms are not fully understood. This study aimed to characterize the plasma lipid profile, Apo distribution, and lipoprotein composition of 80 childhood ALL survivors compared with 22 healthy controls. Our results show that, despite their young age, 50% of the ALL survivors displayed dyslipidemia, characterized by increased plasma triglyceride (TG) and LDL-cholesterol, as well as decreased HDL-cholesterol. ALL survivors exhibited lower plasma Apo A-I and higher Apo B-100 and C-II levels, along with elevated Apo C-II/C-III and B-100/A-I ratios. VLDL fractions of dyslipidemic ALL survivors contained more TG, free cholesterol, and phospholipid moieties, but less protein. Differences in Apo content were found between ALL survivors and controls for all lipoprotein fractions except HDL3HDL2, especially, showed reduced Apo A-I and raised Apo A-II, leading to a depressed Apo A-I/A-II ratio. Analysis of VLDL-Apo Cs disclosed a trend for higher Apo C-III1content in dyslipidemic ALL survivors. In conclusion, this thorough investigation demonstrates a high prevalence of dyslipidemia in ALL survivors, while highlighting significant abnormalities in their plasma lipid profile and lipoprotein composition. Special attention must, therefore, be paid to these subjects given the atherosclerotic potency of lipid and lipoprotein disorders.
authors.affiliation: Research Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.|Department of Nutrition Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Sophia
authors.initials: S
authors.lastname: Morel
authors.affiliation: Research Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.|Department of Nutrition Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Jade
authors.initials: J
authors.lastname: Leahy
authors.affiliation: Research Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.|Department of Nutrition Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Maryse
authors.initials: M
authors.lastname: Fournier
authors.affiliation: Institute of Nutrition and Functional Foods, Laval University, Quebec, Quebec, Canada G1V 0A6.
authors.forename: Benoit
authors.initials: B
authors.lastname: Lamarche
authors.affiliation: Research Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Carole
authors.initials: C
authors.lastname: Garofalo
authors.affiliation: Department of Pediatrics, Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Guy
authors.initials: G
authors.lastname: Grimard
authors.affiliation: Research Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Floriane
authors.initials: F
authors.lastname: Poulain
authors.affiliation: Research Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Edgard
authors.initials: E
authors.lastname: Delvin
authors.affiliation: Research Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.|Department of Pediatrics, Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Caroline
authors.initials: C
authors.lastname: Laverdière
authors.affiliation: Research Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.|Department of Pediatrics, Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Maja
authors.initials: M
authors.lastname: Krajinovic
authors.affiliation: Research Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Simon
authors.initials: S
authors.lastname: Drouin
authors.affiliation: Research Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.|Department of Pediatrics, Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Daniel
authors.initials: D
authors.lastname: Sinnett
authors.affiliation: Research Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.|Department of Nutrition Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Valérie
authors.initials: V
authors.lastname: Marcil
authors.affiliation: Research Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5 emile.levy@recherche-ste-justine.qc.ca.|Department of Nutrition Université de Montréal, Montreal, Quebec, Canada H3T 1C5.|Institute of Nutrition and Functional Foods, Laval University, Quebec, Quebec, Canada G1V 0A6.
authors.forename: Emile
authors.initials: E
authors.lastname: Levy
mesh_terms: D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics; D000073116:Cancer Survivors; D050171:Dyslipidemias / Q000150:complications; D005260:Female; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics; D008074:Lipoproteins / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D008297:Male; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D011973:Receptors, LDL / Q000235:genetics; D055815:Young Adult
chemical_list: D001057:Apolipoproteins E; D008074:Lipoproteins; D011973:Receptors, LDL; C548261:LPL protein, human; D008071:Lipoprotein Lipase
keywords: apolipoproteins; atherosclerosis; cancer; cardiovascular diseases; clinical studies; dyslipidemia; lipid and lipoprotein metabolism; metabolic syndrome