title: Data-Driven Antibody Engineering Using Genedata Biologics™.
abstract: Genedata Biologics is a novel informatics platform specifically designed for biologics R&D. Here, we discuss the main principles employed in designing such a platform, focusing on antibody engineering. To illustrate, we present a case study of how the platform effectively supports an antibody optimization workflow and ensures the successful integration and analysis of all relevant sequence, expression, assay, and analytics data.
authors.affiliation: Genedata AG, Margarethenstrasse 38, 4053, Basel, Switzerland. maria.wendt@genedata.com.
authors.forename: Maria
authors.initials: M
authors.lastname: Wendt
authors.affiliation: Genedata AG, Margarethenstrasse 38, 4053, Basel, Switzerland.
authors.forename: Guido
authors.initials: G
authors.lastname: Cappuccilli
mesh_terms: D000906:Antibodies / Q000302:isolation & purification*; D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D004353:Drug Evaluation, Preclinical; D015202:Protein Engineering / Q000379:methods; D012984:Software; D014584:User-Computer Interface
chemical_list: D000906:Antibodies
keywords: Antibody engineering; Antibody library design; Bioinformatics; Biologics database; Data visualization; Mutagenesis