title: The Effect of Individualized Versus Standardized Parenteral Nutrition on Body Weight in Very Preterm Infants.
abstract: BACKGROUND
  This study was designed to evaluate whether standardizing total parenteral nutrition (TPN) is at least non-inferior to TPN with individualized composition in premature infants with a gestational age (GA) < 32 weeks.
  
  
  METHODS
  In this retrospective cohort study, all preterm born in or transferred to Maxima Medical Center (MMC) within 24 hours after birth with a GA < 32 weeks were included. The individualized group (2011) was compared to the partially standardized group (2012) and completely standardized group (2014) consequently. The primary endpoint was difference in growth. Secondary endpoints included differences in electrolyte concentrations.
  
  
  RESULTS
  A total of 299 preterm were included in this study. When comparing weight gain, the infants in the (partially) standardized group demonstrated significantly (P < 0.05) less weight loss during the first days of life and grew faster subsequently in the following days than the individualized TPN regimen. Furthermore, significant differences in abnormal serum sodium, chloride, calcium, creatinine, magnesium and triglycerides values were demonstrated.
  
  
  CONCLUSIONS
  TPN with a (partially) standardized composition revealed to be at least non-inferior to TPN with an individualized composition.
authors.affiliation: Department of Clinical Pharmacy, Maxima Medical Center, Veldhoven, The Netherlands.
authors.forename: Vincent H M
authors.initials: VH
authors.lastname: Evering
authors.affiliation: Department of Pediatrics, Maxima Medical Center, Veldhoven, The Netherlands; Faculty of Health, Medicine and Life Science, Maastricht University, Maastricht, The Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Andriessen
authors.affiliation: Department of Pediatrics, Maxima Medical Center, Veldhoven, The Netherlands.
authors.forename: Carola E P M
authors.initials: CE
authors.lastname: Duijsters
authors.affiliation: Department of Clinical Pharmacy, Maxima Medical Center, Veldhoven, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Brogtrop
authors.affiliation: Department of Clinical Pharmacy, Maxima Medical Center, Veldhoven, The Netherlands.
authors.forename: Luc J J
authors.initials: LJ
authors.lastname: Derijks
keywords: Parenteral nutrition; Preterm infant; Weight gain