title: Alteration of Spontaneous Brain Activity After Hypoxia-Reoxygenation: A Resting-State fMRI Study.
abstract: Zhang, Jiaxing, Ji Chen, Cunxiu Fan, Jinqiang Li, Jianzhong Lin, Tianhe Yang, and Ming Fan. Alteration of spontaneous brain activity after hypoxia-reoxygenation: A resting-state fMRI study. High Alt Med Biol. 18:20-26, 2017.-The present study was designed to investigate the effect of hypoxia-reoxygenation on the spontaneous neuronal activity in brain. Sixteen sea-level (SL) soldiers (20.5 ± 0.7 years), who garrisoned the frontiers in high altitude (HA) (2300-4400 m) for two years and subsequently descended to sea level for one to seven days, were recruited. Control group consisted of 16 matched SL natives. The amplitude of low-frequency fluctuations (ALFF) of regional brain functional magnetic resonance imaging signal in resting state and functional connectivity (FC) between brain regions was analyzed. HA subjects showed significant increases of ALFF at several sites within the bilateral occipital cortices and significant decreases of ALFF in the right anterior insula and extending to the caudate, putamen, inferior frontal orbital cortex, temporal pole, and superior temporal gyrus; lower ALFF values in the right insula were positively correlated with low respiratory measurements. The right insula in HA subjects had increases of FC with the right superior temporal gyrus, postcentral gyrus, rolandic operculum, supramarginal gyrus, and inferior frontal triangular area. We thus demonstrated that hypoxia-reoxygenation had influence on the spontaneous neuronal activity in brain. The decrease of insular neuronal activity may be related to the reduction of ventilatory drive, while the increase of FC with insula may indicate a central compensation.
authors.affiliation: 1 Department of Physiology, Medical College of Xiamen University , Xiamen, China .
authors.forename: Jiaxing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: 1 Department of Physiology, Medical College of Xiamen University , Xiamen, China .
authors.forename: Ji
authors.initials: J
authors.lastname: Chen
authors.affiliation: 1 Department of Physiology, Medical College of Xiamen University , Xiamen, China .
authors.forename: Cunxiu
authors.initials: C
authors.lastname: Fan
authors.affiliation: 2 Department of Clinical Psychology, Gulangyu Sanatorium of PLA , Xiamen, China .
authors.forename: Jinqiang
authors.initials: J
authors.lastname: Li
authors.affiliation: 3 Magnetic Resonance Center, Zhongshan Hospital Xiamen University , Xiamen, China .
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Lin
authors.affiliation: 3 Magnetic Resonance Center, Zhongshan Hospital Xiamen University , Xiamen, China .
authors.forename: Tianhe
authors.initials: T
authors.lastname: Yang
authors.affiliation: 4 Department of Cognitive Sciences, Institute of Basic Medical Sciences , Beijing, China .
authors.forename: Ming
authors.initials: M
authors.lastname: Fan
mesh_terms: D000531:Altitude; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D002681:China; D006801:Humans; D000860:Hypoxia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008889:Military Personnel; D010101:Oxygen Consumption / Q000502:physiology; D012146:Rest / Q000502:physiology*; D055815:Young Adult
keywords: ALFF; brain; functional connectivity; hypoxia; insula