title: [New predictors in prodromal Alzheimer: Deferred phase in word recall of MIS test].
abstract: BACKGROUND
  The Memory Impairment Screen (MIS-A) is a validated test to detect Alzheimer's Disease (AD) and other dementias. We have modified this test to suit a Spanish speaking population and added a new component, delayed recall (MIS-D).
  
  
  OBJECTIVE
  1) To test a Spanish version of MIS-A and MIS-D. 2) To assess the discriminative validity of MIS-D as a screening tool for the amnestic variant of Mild Cognitive Impairment (aMCI).
  
  
  METHODS
  A case-control study of a cohort of 739 aged 65 years old and over, of whom 436 were healthy controls and 303 had a diagnosis of aMCI. The MCI group was patients from the Geriatric Unit for the Elderly at the Italian Hospital of Buenos Aires staffed by geriatricians.
  
  
  METHODS
  ANOVA test and test t de Student mean comparison. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NVP) were estimated for MIS-D and MIS-A.
  
  
  RESULTS
  Normative values for MIS-A and MIS-D were obtained from the control population. Both age and education significantly affected these values (p<0.0001). The cut-off for MIS-A should be 7.5 and for MIS-D, 5.5. Comparison between control population and aMCI population using ROC curve gave a result of 5.5 in MIS-D, with 97% specificity and 76% sensitivity.
  
  
  CONCLUSIONS
  MIS-D was positively predictive of Amci. An extension of the sample in other health care contexts would enable us to verify its clinical validity for other populations.
authors.affiliation: Departamento de Salud Pública, Facultad de Medicina, Universidad de Buenos Aires. elabos@arnet.com.ar.
authors.forename: Edith
authors.initials: E
authors.lastname: Labos
authors.forename: Sofía
authors.initials: S
authors.lastname: Trojanowski
authors.forename: Marcelo
authors.initials: M
authors.lastname: Schapira
authors.forename: Daniel
authors.initials: D
authors.lastname: Seinhart
authors.forename: Alejandro
authors.initials: A
authors.lastname: Renato
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology*; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D062706:Prodromal Symptoms