title: Aquaporins in Respiratory System.
abstract: Aquaporins (AQPs ) are water channel proteins supposed to facilitating fluid transport in alveolar space, airway humidification, pleural fluid absorption, and submucosal gland secretion . In this chapter, we mainly focus on the expression of 4 AQPs in the lungs which include AQP1, AQP2 , AQP4 and AQP5 in normal and disease status, and the experience of AQPs function from various model and transgenic mice were summarized in detail to improve our understanding of the role of AQPs in fluid balance of respiratory system. It has been suggested that AQPs play important roles in various physiology and pathophysiology conditions of different lung diseases. There still remains unclear the exact role of AQPs in lung diseases, and thus continuous efforts on elucidating the roles of AQPs in lung physiological and pathophysilogical processes are warranted.
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. song.yuanlin@zs-hospital.sh.cn.|Shanghai Respiratory Research Institute, Shanghai Public Health Clinical Center, Shanghai, 201508, China. song.yuanlin@zs-hospital.sh.cn.|Zhongshan Hospital, Qingpu Branch, Fudan University, Shanghai, 201700, China. song.yuanlin@zs-hospital.sh.cn.
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Chunxue
authors.initials: C
authors.lastname: Bai
mesh_terms: D055371:Acute Lung Injury / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D051398:Aquaporin 1 / Q000235:genetics / Q000378:metabolism*; D001249:Asthma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D001692:Biological Transport; D015972:Gene Expression Regulation, Neoplastic; D020397:Goblet Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D020545:Respiratory Mucosa / Q000166:cytology / Q000378:metabolism*; D014867:Water / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: C496020:AQP1 protein, human; D020033:Protein Isoforms; D014867:Water; D051398:Aquaporin 1
keywords: Aquaporins; Fluid transport; Lung disorders