title: Cyclophosphamide and Doxorubicin Induced Melanonychia: A Case Report.
abstract: Chemotherapeutic agents may rarely cause discoloration and hyperpigmentation of the nails. We present a patient who developed blackish discoloration of nails also referred as melanonychia during six cycles of R-CHOP chemotherapy regimen (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) for the treatment of Non Hodgkin Lymphoma (NHL) follicular type. The patient developed blackish brown discoloration in all the nails. As suggested by previous literature evidence the melanonychia could be associated with cyclophosphamide and doxorubicin. According to the Naranjo causality assessment scale, we established that there was a 'probable' association of nail discoloration with the drug.
authors.affiliation: Intern, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University , Manipal, Karnataka, India .
authors.forename: Vivek Bhanubhai
authors.initials: VB
authors.lastname: Prajapati
authors.affiliation: Assistant Professor, Department of General Medicine, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
authors.forename: Sharath
authors.initials: S
authors.lastname: Madhyastha
authors.affiliation: Professor, Department of General Medicine, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
authors.forename: Raviraj
authors.initials: R
authors.lastname: Acharya
authors.affiliation: Senior Resident, Department of General Medicine, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
authors.forename: Vinaya
authors.initials: V
authors.lastname: Gopalaswamy
authors.affiliation: Lady Medical Officer, Department of Community Medicine, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
authors.forename: Akhila
authors.initials: A
authors.lastname: Doddamani
keywords: Chemotherapy; Hyperpigmentation; Naranjo causality assessment scale; Non Hodgkin lymphoma