title: Follicular lymphoma transforming into diffuse large B-cell lymphoma in spleen: Simultaneous appearance of both on18F-FDG PET/CT and histology.
abstract: Low grade lymphoma may transform into a more aggressive lymphoma and this transformation is usually associated with a poor outcome. A 65year old man presented with two metabolically active splenic lesions on a staging [18F] fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). Histologic evaluation post splenectomy confirmed the presence of two clonally related lymphomas: a follicular lymphoma (FL) and a diffuse large B-cell lymphoma (DLBCL). Molecular genetic studies confirmed that the DLBCL lesions arose from a pre-existing FL. We present the18F-FDG PET/CT imaging characteristics of both lymphoma types which were simultaneously present in the spleen.
authors.affiliation: Department of Diagnostic Imaging, Cross Cancer Institute, 11560 University Ave NW, Edmonton, Alberta, T6G 1Z2, Canada. Electronic address: makisw79@yahoo.com.
authors.forename: William
authors.initials: W
authors.lastname: Makis
authors.affiliation: Department of Nuclear Medicine, MUHC McGill University Health Centre, Glen Site, 1001 Boul Decarie, Montreal, Quebec, H4A 3J1, Canada.
authors.forename: Anthony
authors.initials: A
authors.lastname: Ciarallo
authors.affiliation: Department of Pathology, Jewish General Hospital, Montreal, QC, Canada.
authors.forename: Tina
authors.initials: T
authors.lastname: Petrogiannis-Haliotis
authors.affiliation: Department of Pathology, Jewish General Hospital, Montreal, QC, Canada.
authors.forename: Arthur
authors.initials: A
authors.lastname: Rosenberg
authors.affiliation: Department of Nuclear Medicine, Jewish General Hospital, Montreal, QC, Canada.
authors.forename: Stephan
authors.initials: S
authors.lastname: Probst
mesh_terms: D000368:Aged; D002471:Cell Transformation, Neoplastic; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008224:Lymphoma, Follicular / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008297:Male; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013154:Spleen / Q000473:pathology* / Q000601:surgery; D013156:Splenectomy; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)F–FDG; DLBCL; Follicular lymphoma; Histology; PET/CT; Spleen; Transformation