title: Increased cardiorespiratory coordination in preeclampsia.
abstract: Preeclampsia is one of the main sources of morbidity in pregnancy with a high mortality rate without a known ultimate cause. Using a corpus including 927 measurements of pregnant women with and without different hypertonic diseases at multiple stages of pregnancy, we utilised a new approach to analyse cardiorespiratory coordination. Since the recording quality of respiratory effort was limited due to a high signal to noise ratio, we applied an ECG derived respiration approach to create an ersatz respiratory signal. After applying the few available recordings with a sufficiently high quality of the respiratory signal to validate the substitute, coordigrams were calculated and quantified by utilising an epsilon method. We showed significant (p  <  0.05) differences in the coordination in a matched (BMI, age, gestational week) comparison of preeclamptic and healthy subjects. Hopefully future applications of and improvements on these methods are able to create a fast and convenient prediction methodology to reduce the impact of this disease as well as help in the determination of its underlying cause.
authors.affiliation: AG NLD-Cardiovascular Physics, Humboldt-Universität zu Berlin, Robert-Koch-Platz 4, 10115 Berlin, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Berg
authors.forename: Jan F
authors.initials: JF
authors.lastname: Kraemer
authors.forename: Maik
authors.initials: M
authors.lastname: Riedl
authors.forename: Holger
authors.initials: H
authors.lastname: Stepan
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kurths
authors.forename: Niels
authors.initials: N
authors.lastname: Wessel
mesh_terms: D000328:Adult; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D012119:Respiration; D059629:Signal-To-Noise Ratio