title: Impact of variations in blood pressure with orthostatism on mortality: the HOMO study.
abstract: OBJECTIVE
  The aim of this study was to determine the impact of orthostatic hypotension (OH) and orthostatic hypertension (OHT) on all-cause mortality.
  
  
  METHODS
  A total of, 1176 adults from the community over 18 years of age were included in this ambispective study. The mean follow-up was 9.4 years. OH and OHT were defined as a decrease or an increase, respectively, in systolic blood pressure (BP) of at least 20 mmHg and/or diastolic BP of at least 10 mmHg from sitting to standing position at 1 and/or 3 min after standing. The impact of systolic or diastolic OH and systolic or diastolic OHT at 1 and 3 min after standing was also analyzed separately.
  
  
  RESULTS
  In total, 135 individuals died during the follow-up. Neither OH [hazard ratio (HR) 1.23; 95% confidence interval (CI): 0.72-2.10] nor OHT (HR 0.90; 95% CI: 0.59-1.38) was associated with all-cause mortality in the adjusted models. In contrast, systolic OHT at 3 min (HR 2.31; 95% CI: 1.14-4.68) was independently associated with global mortality.
  
  
  CONCLUSIONS
  Systolic OHT at 3 min is associated with all-cause mortality. The determination of this parameter could add valuable prognostic information during the routine examination of patients.
authors.affiliation: aPrimary Care Center Arnedo, Arnedo, La Rioja bCardiology Department, La Paz University Hospital cInternal Medicine, Ramón y Cajal University Hospital, Madrid dPrimary Care Center Vallobín-La Florida, Oviedo, Asturias eDivision of Epidemiology and Disease Prevention, La Rioja Regional Authority,Logroño fPrimary Care Center Castilla-Hermida, Santander, Cantabria, Spain.
authors.forename: Sonsoles M
authors.initials: SM
authors.lastname: Velilla-Zancada
authors.forename: Carlos
authors.initials: C
authors.lastname: Escobar-Cervantes
authors.forename: Luis
authors.initials: L
authors.lastname: Manzano-Espinosa
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Prieto-Diaz
authors.forename: Enrique
authors.initials: E
authors.lastname: Ramalle-Gomara
authors.forename: Luis A
authors.initials: LA
authors.lastname: Vara-Gonzalez
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007024:Hypotension, Orthostatic / Q000401:mortality* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate