title: Altered Topological Properties of Brain Networks in Social Anxiety Disorder: A Resting-state Functional MRI Study.
abstract: Recent studies involving connectome analysis including graph theory have yielded potential biomarkers for mental disorders. In this study, we aimed to investigate the differences of resting-state network between patients with social anxiety disorder (SAD) and healthy controls (HCs), as well as to distinguish between individual subjects using topological properties. In total, 42 SAD patients and the same number of HCs underwent resting functional MRI, and the topological organization of the whole-brain functional network was calculated using graph theory. Compared with the controls, the patients showed a decrease in 49 positive connections. In the topological analysis, the patients showed an increase in the area under the curve (AUC) of the global shortest path length of the network (Lp) and a decrease in the AUC of the global clustering coefficient of the network (Cp). Furthermore, the AUCs of Lpand Cpwere used to effectively discriminate the individual SAD patients from the HCs with high accuracy. This study revealed that the neural networks of the SAD patients showed changes in topological characteristics, and these changes were prominent not only in both groups but also at the individual level. This study provides a new perspective for the identification of patients with SAD.
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.|State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Hongru
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Changjian
authors.initials: C
authors.lastname: Qiu
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.|State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Meng
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Minlan
authors.initials: M
authors.lastname: Yuan
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Zhengjia
authors.initials: Z
authors.lastname: Ren
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Li
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Huang
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.|Radiology Department of the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027 China.
authors.forename: Su
authors.initials: S
authors.lastname: Lui
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.|State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D019540:Area Under Curve; D044466:Asian People; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000473:pathology*; D000072861:Phobia, Social / Q000473:pathology*; D012146:Rest; D055815:Young Adult