title: Radiofrequency electromagnetic radiation from cell phone causes defective testicular function in male Wistar rats.
abstract: Cell phones have become an integral part of everyday life. As cell phone usage has become more widespread, concerns have increased regarding the harmful effects of radiofrequency electromagnetic radiation from these devices. The current study was undertaken to investigate the effects of the emitted radiation by cell phones on testicular histomorphometry and biochemical analyses. Adult male Wistar rats weighing 180-200 g were randomly allotted to control, group A (switched off mode exposure), group B (1-hr exposure), group C (2-hr exposure) and group D (3-hr exposure). The animals were exposed to radiofrequency electromagnetic radiation of cell phone for a period of 28 days. Histomorphometry, biochemical and histological investigations were carried out. The histomorphometric parameters showed no significant change (p < .05) in the levels of germinal epithelial diameter in all the experimental groups compared with the control group. There was no significant change (p < .05) in cross-sectional diameter of all the experimental groups compared with the control group. Group D rats showed a significant decrease (p ˂ .05) in lumen diameter compared with group B rats. There was an uneven distribution of germinal epithelial cells in groups B, C and D. However, there was degeneration of the epithelia cells in group D when compared to the control and group B rats. Sera levels of malondialdehyde (MDA) and superoxide dismutase (SOD), which are markers of reactive oxygen species, significantly increased (MDA) and decreased (SOD), respectively, in all the experimental groups compared with the control group. Also sera levels of gonadotropic hormones (FSH, LH and testosterone) significantly decreased (p < .05) in groups C and D compared with the control group. The study demonstrates that chronic exposure to radiofrequency electromagnetic radiation of cell phone leads to defective testicular function that is associated with increased oxidative stress and decreased gonadotropic hormonal profile.
authors.affiliation: Department of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
authors.forename: A O
authors.initials: AO
authors.lastname: Oyewopo
authors.affiliation: Department of Physiology, University of Ilorin, Ilorin, Nigeria.
authors.forename: S K
authors.initials: SK
authors.lastname: Olaniyi
authors.affiliation: Department of Anesthesia, University of Ilorin Teaching Hospital, University of Ilorin, Ilorin, Nigeria.
authors.forename: C I
authors.initials: CI
authors.lastname: Oyewopo
authors.affiliation: Department of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
authors.forename: A T
authors.initials: AT
authors.lastname: Jimoh
mesh_terms: D000818:Animals; D040421:Cell Phone; D060733:Electromagnetic Radiation; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013737:Testis / Q000378:metabolism / Q000528:radiation effects*; D013739:Testosterone / Q000097:blood
chemical_list: D017382:Reactive Oxygen Species; D013739:Testosterone; D008315:Malondialdehyde; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013482:Superoxide Dismutase
keywords: cell phone; histomorphometry; infertility; malondialdehyde; radiofrequency electromagnetic radiation; superoxide dismutase