title: New metabolites from the sponge-derived fungus Aspergillus sydowii J05B-7F-4.
abstract: Two new metabolites, diorcinolic acid (1) and β-d-glucopyranosyl aspergillusene A (8), together with six diphenylethers (2-7), a diketopiperazine (9), a chromone (10) and a xanthone (11) were isolated from the fungus Aspergillus sydowii derived from the marine sponge Stelletta sp. The planar structures and their relative configurations were elucidated by analysing 1D, 2D NMR and HRESIMS data. Compound 8 is the first glycoside of phenolic bisabolane sesquiterpenes. Compounds 1 and 8 exhibited mild cytotoxicity against KB (human nasopharyngeal carcinoma cells), HepG2 (human liver cancer cells) and HCT 116 (human colon cancer cells). All compounds were evaluated for antibacterial activity and their abilities to suppress LPS-induced nitric oxide (NO) production. Compounds 2 and 4-7 showed mild antibacterial activity against human pathogen Staphylococcus aureus and fish pathogens Streptococcus iniae and Vibrio ichthyoenteri, and compounds 4 and 7 weakly suppressed NO production.
authors.affiliation: a College of Pharmacy , Pusan National University , Busan , Republic of Korea.
authors.forename: Sen
authors.initials: S
authors.lastname: Liu
authors.affiliation: a College of Pharmacy , Pusan National University , Busan , Republic of Korea.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.affiliation: a College of Pharmacy , Pusan National University , Busan , Republic of Korea.
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Su
authors.affiliation: a College of Pharmacy , Pusan National University , Busan , Republic of Korea.
authors.forename: Gwi Ja
authors.initials: GJ
authors.lastname: Hwang
authors.affiliation: b College of Pharmacy , Kyung Hee University , Seoul , Republic of Korea.
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.affiliation: a College of Pharmacy , Pusan National University , Busan , Republic of Korea.
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry* / Q000378:metabolism; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D011161:Porifera / Q000382:microbiology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes; D009569:Nitric Oxide
keywords: Aspergillus sydowii; Marine fungus; antibacterial activity; cytotoxicity; diphenylether; no suppression; sesquiterpene glycoside