title: Granulomatosis with polyangiitis involving the epiglottis.
abstract: Granulomatosis with polyangiitis (GPA) frequently involves the upper respiratory tracts, but involvement of the epiglottis is extremely rare. This report describes a patient initially presenting with dysphagia and increasing stridor due to epiglottitis. Bronchoscopy showed swelling of the epiglottis with partly whitish nodular lesions, with biopsy specimens showing neutrophil infiltration and necrosis. Chest computed tomography showed multiple nodular consolidations in the bilateral lung parenchyma, and histological findings were consistent with vasculitis. The patient was diagnosed with GPA and responded well to treatment with prednisolone and cyclophosphamide. Although an uncommon manifestation, GPA should be included in the differential diagnosis of epiglottitis, especially in patients with lung parenchymal lesions suggestive of GPA.
authors.affiliation: Department of Respiratory Medicine Iwata City Hospital Iwata Japan.
authors.forename: Yuya
authors.identifier: 0000-0001-6132-2810
authors.initials: Y
authors.lastname: Aono
authors.affiliation: Department of Respiratory Medicine Iwata City Hospital Iwata Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Imokawa
authors.affiliation: Department of Respiratory Medicine Iwata City Hospital Iwata Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Uto
authors.affiliation: Department of Respiratory Medicine Iwata City Hospital Iwata Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Sato
authors.affiliation: Division of Pathology Iwata City Hospital Iwata Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Tanioka
authors.affiliation: Second Division, Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
keywords: Multiple pulmonary nodular consolidations; upper respiratory tract; vasculitis