title: Anti-aging Role of Curcumin by Modulating the Inflammatory Markers in Albino Wistar Rats.
abstract: OBJECTIVE
  Advanced age is associated with an accumulation of free radical damage, which leads to physiological and clinical modifications. Numerous pharmaceutical and nutraceuticals are considered to influence longevity and prompting healthy ageing. Therefore, the current study attempted to investigate Curcumin's role in the inflammatory indices as anti-ageing marker in albino Wistar rats.
  
  
  METHODS
  Twelve months old rats were used in the study, grouped as Normal control (NC), Sham control (SC), Curcumin-1, Curcumin-2 and Curcumin-3. Last three groups received Curcumin at the dosages of 100 mg, 200 mg and 400 mg/kg body weight respectively. After six months of intervention, blood was collected for the estimation of C-reactive protein (CRP), Serum Albumin, Globulin, Lymphocyte percentage, Total Antioxidant Capacity (TAC), Malondialdehyde (MDA), Superoxide Dismutase (SOD) and Nitric Oxide (NO) level using standard procedures.
  
  
  RESULTS
  There was a significant decline in the CRP level (p < 0.05) in rats treated with 200 mg and 400 mg of Curcumin/kg body weight. The MDA level was found to be significantly increased (p < 0.05) in animals fed with 400 mg of Curcumin/kg body weight as compared to NC. The NO level was increased significantly (p < 0.05) in rats treated with 200 and 400 mg of Curcumin/kg body weight.
  
  
  CONCLUSIONS
  Finding of the study suggests that Curcumin exhibits favorable influence in slowing down of ageing process by suppressing age-related changes in inflammatory indices.
authors.affiliation: Department of Physiology, K.S. Hegde Medical Academy, Nitte University, Mangalore, India.
authors.forename: Moodithaya
authors.initials: M
authors.lastname: Shailaja
authors.affiliation: Department of Physiology, K.S. Hegde Medical Academy, Nitte University, Mangalore, India. Electronic address: dr_damodar@nitte.edu.in.
authors.forename: K M
authors.initials: KM
authors.lastname: Damodara Gowda
authors.affiliation: Central Research Laboratory, K.S. Hegde Medical Academy, Nitte University, Mangalore, India.
authors.forename: Kedilaya
authors.initials: K
authors.lastname: Vishakh
authors.affiliation: Department of Biochemistry, K.S. Hegde Medical Academy, Nitte University, Mangalore, India.
authors.forename: N
authors.initials: N
authors.lastname: Suchetha Kumari
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003474:Curcumin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals / Q000378:metabolism; D007249:Inflammation / Q000097:blood / Q000188:drug therapy; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D005609:Free Radicals; D008315:Malondialdehyde; D002097:C-Reactive Protein; D013482:Superoxide Dismutase; D003474:Curcumin
keywords: Anti-aging; C-reactive protein; Curcumin; Malondialdehyde; Nitric Oxide; Superoxide dismutase; Total antioxidant capacity