title: Regulation of Embryonic Stem Cell Self-Renewal and Differentiation by MicroRNAs.
abstract: MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. They play an important role in various cellular processes such as apoptosis, differentiation, secretion, and proliferation. Embryonic stem cells (ESCs) are derived from the inner cell mass of the blastocyst stage of the embryo. miRNAs are critical factors for the self-renewal and differentiation of ESCs. In this review, we will focus on the role of miRNAs in the self-renewal and directional differentiation of ESCs. We will present the current knowledge on key points related to miRNA biogenesis and their function in ESCs.
authors.affiliation: 1 Department of Medical Laboratory, Xinqiao Hospital, Third Military Medical University , Chongqing, China .|2 State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, College of Preventive Medicine, Third Military Medical University , Chongqing, China .
authors.forename: Xi
authors.initials: X
authors.lastname: Ran
authors.affiliation: 3 Qingdao First Sanatorium of Jinan Military Command , Qingdao, China .
authors.forename: Chun-Hong
authors.initials: CH
authors.lastname: Xiao
authors.affiliation: 1 Department of Medical Laboratory, Xinqiao Hospital, Third Military Medical University , Chongqing, China .
authors.forename: Gui-Ming
authors.initials: GM
authors.lastname: Xiang
authors.affiliation: 2 State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, College of Preventive Medicine, Third Military Medical University , Chongqing, China .
authors.forename: Xin-Ze
authors.initials: XZ
authors.lastname: Ran
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D000066449:Human Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
keywords: differentiation; embryonic stem cells; microRNAs; regulation; self-renewal