title: Regulation of endometrial cell proliferation by estrogen-induced BDNF signaling pathway.
abstract: Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin growth factors family. Recent studies indicated that the level of BDNF in follicular fluid is a marker for oocyte quality and infertility. Here, we intend to further investigate the function of BDNF and its signaling pathway in the regulation of endometrial cells proliferation. We found that BDNF is a critical growth factor in endometrial cells. Activation of signal transducer and activator of transcription 3 signaling pathway is required for BNDF-regulated endometrial cell proliferation. Furthermore, BDNF is an effector of estrogen in endometrial cells. Finally, we investigated the different role of Val66Met, a single-nucleotide polymorphism of the BDNF gene, in regulating endometrial cells proliferation. The results showed that BDNFV66Mpolymorphism is a loss-of-function polymorphism in the regulation of endometrial cells growth. Given the correlation between endometriosis and infertility, it is important to understand the role of BDNF in regulating endometrial cells proliferation and to develop new therapeutic strategies for the treatment of endometriosis-related infertility.
authors.affiliation: a Department of Pharmacology , Boston University School of Medicine , Boston , MA , USA.
authors.forename: Fangzheng
authors.initials: F
authors.lastname: Dong
authors.affiliation: b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of TCM , Jinan , China , and.
authors.forename: Qiyao
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of TCM , Jinan , China , and.
authors.forename: Wei
authors.initials: W
authors.lastname: Kong
authors.affiliation: b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of TCM , Jinan , China , and.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: c Department of Microbiology , University of Iowa , Iowa City , IA , USA.
authors.forename: Junlan
authors.initials: J
authors.lastname: Ma
authors.affiliation: b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of TCM , Jinan , China , and.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of TCM , Jinan , China , and.
authors.forename: Yanian
authors.initials: Y
authors.lastname: Wang
authors.affiliation: b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of TCM , Jinan , China , and.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of TCM , Jinan , China , and.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of TCM , Jinan , China , and.
authors.forename: Ji
authors.initials: J
authors.lastname: Wen
mesh_terms: D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004717:Endometrium / Q000502:physiology*; D004967:Estrogens / Q000502:physiology; D005260:Female; D006801:Humans; D000073658:Loss of Function Mutation; D011110:Polymorphism, Genetic; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D004967:Estrogens; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C579455:BDNF protein, human
keywords: Brain-derived neurotrophic factor; endometrial cells; endometriosis Val66Met; signal transducer and activator of transcription 3