title: Photocatalytic activity against azo dye and cytotoxicity on MCF-7 cell lines of zirconium oxide nanoparticle mediated using leaves of Lagerstroemia speciosa.
abstract: Metal oxide nanoparticles are gaining interest in recent years. The present paper explains about the green synthesis of zirconium oxide nanoparticles (ZrO NPs) mediated from the leaves of Lagerstroemia speciosa. The prepared ZrO NPs were characterized by UV-vis spectroscopy, FT-IR, X-ray diffraction analysis (XRD), Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray spectroscopy (EDX) and Thermogravimetric Analysis (TGA). The photocatalytic activity of ZrO NPs was studied for azo dye by exposing to sunlight. The azo dye was degraded up to 94.58%. Also the ZrO NPs were studied for in vitro cytotoxicity activity against breast cancer cell lines-MCF-7 and evaluated by MTT assay. The cell morphological changes were recorded by light microscope. The cells viability was seen at 500μg/mL when compared against control. Hence the research highlights, that the method was simple, eco-friendly towards environment by phytoremediation activity of the azo dye and cytotoxicity activity against MCF-7 cell lines. Hence the present paper may help to further explore the metal nanoparticle for its potential applications.
authors.affiliation: Department of Chemistry, SAS, VIT University, Vellore 632014, India.
authors.forename: V
authors.initials: V
authors.lastname: Sai Saraswathi
authors.affiliation: CO(2) Research and Green Technologies Centre, VIT University, Vellore 632014, India. Electronic address: ksanthakumar@vit.ac.in.
authors.forename: K
authors.initials: K
authors.lastname: Santhakumar
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001391:Azo Compounds / Q000378:metabolism / Q000528:radiation effects; D001673:Biodegradation, Environmental / Q000187:drug effects / Q000528:radiation effects; D002384:Catalysis; D016923:Cell Death / Q000187:drug effects*; D048430:Cell Shape / Q000187:drug effects; D004396:Coloring Agents / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D031563:Lagerstroemia; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry*; D018515:Plant Leaves; D013472:Sunlight; D015040:Zirconium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D001391:Azo Compounds; D004396:Coloring Agents; D015040:Zirconium; C028541:zirconium oxide
keywords: Lagerstroemia speciosa; MCF-7 cell lines; Photocatalytic activity; TEM; XRD; Zirconium oxide nanoparticles