title: The influence of comorbidities on the aging males' symptoms scale in patients with erectile dysfunction.
abstract: OBJECTIVE
  To investigate if certain common age-related comorbidities are related with a positive aging males' symptoms (AMS) test outcome.
  
  
  METHODS
  This was a multicentric, transversal, observational study carried out in a male population with erectile dysfunction. Comorbidities and testosterone levels were registered. The relationship between comorbidities, testosterone levels, and the AMS test outcomes was studied using the global score and the sub-scale score components.
  
  
  RESULTS
  The study included 1112 patients. In the multivariate analysis the global score strongly correlated with TT < 12 nmol/L (odds ratio [OR] = 3.17; p < 0.05), psychiatric disorders (OR = 2.73), dyslipidemia (OR = 2.07) and diabetes mellitus (OR = 1.64); the somatic sub-component was related to obesity (OR = 8.62), dyslipidemia (OR = 2.2) and TT < 12 nmol/L (OR = 2.09); the psychogenic sub-component correlated with psychiatric disorders (OR = 3.73), stress (OR = 2.42), dyslipidemia (OR = 1.78) and TT < 12 nmol/L (OR = 1.77); and the sexual sub-component was associated with high blood pressure (OR = 2.94).
  
  
  CONCLUSIONS
  Although the AMS test is related to low levels of testosterone, it is also of some limited use for diagnosing hypogonadism because it has low specificity and is influenced by pathologies that are frequent during ageing.
authors.affiliation: a Department of Urology , University Clinic Hospital of Valencia, Universitat de València , Av Blasco Ibáñez, Valencia , Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Panach-Navarrete
authors.affiliation: a Department of Urology , University Clinic Hospital of Valencia, Universitat de València , Av Blasco Ibáñez, Valencia , Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Martínez-Jabaloyas
authors.affiliation: a Department of Urology , University Clinic Hospital of Valencia, Universitat de València , Av Blasco Ibáñez, Valencia , Spain.
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood* / Q000502:physiology; D015897:Comorbidity; D007172:Erectile Dysfunction / Q000209:etiology*; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
chemical_list: D013739:Testosterone
keywords: Testosterone; aging males’ symptoms scale; androgen deficiency; diabetes; hypertension; hypogonadism