title: A case of Turner syndrome (46XXp-/45X) complicated with Crohn's disease after hormone therapy.
abstract: A 19-year-old woman, who had been receiving hormone replacement therapy for 13 months before the diagnosis of mosaic Turner syndrome (46XXp-/45X), developed Crohn's colitis and erythema nodosum of the lower legs. Colonoscopy revealed an anal fistula and the presence of deep longitudinal ulcers with cobblestoning in the colorectum. Therapy with prednisolone and adalimumab was effective for the intestinal and skin lesions. To date, all seven case reports of Turner syndrome in Japan have also developed Crohn's disease after hormone therapy, suggesting a possible association of sex hormones in the pathogenesis.
authors.affiliation: Department of Gastroenterology, Kyushu Central Hospital.
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Ihara
authors.forename: Kazuoki
authors.initials: K
authors.lastname: Hizawa
authors.forename: Kouhei
authors.initials: K
authors.lastname: Fujita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iida
authors.forename: Ema
authors.initials: E
authors.lastname: Washio
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kai
authors.forename: Tomoki
authors.initials: T
authors.lastname: Nitahata
authors.forename: Motohiro
authors.initials: M
authors.lastname: Esaki
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Iida
mesh_terms: D041321:Chromosomes, Human, X; D003113:Colonoscopy; D003424:Crohn Disease / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D014057:Tomography, X-Ray Computed; D014424:Turner Syndrome / Q000150:complications* / Q000188:drug therapy*; D055815:Young Adult