title: The diagnostic and prognostic value of interleukin-10 in cerebrospinal fluid for central nervous system lymphoma: a meta-analysis.
abstract: Central nervous system lymphoma (CNSL) presents diagnostic and prognostic challenges. The aim of this meta-analysis was to evaluate the diagnostic and prognostic value of interleukin (IL)-10 in cerebrospinal fluid (CSF) for CNSL comprehensively. PubMed and Cochrane Library databases were searched through September 2016. Four studies with 212 CNSL patients and 262 control patients were included. The pooled sensitivity and specificity of CSF IL-10 for diagnosing CNSL were 81% (95% CI: 66-91%) and 97% (95% CI: 83-100%), respectively. The summary receiver operating characteristic (SROC) curve indicated that the area under the curve was 0.95 (0.93-0.97). The ROC curve based on extracted individual data showed that the optimal cutoff value was 6.88 pg/ml. Moreover, elevated CSF IL-10 was found to be associated with shorter progression-free survival (hazard ratio: 2.89, 95% CI: 1.13-7.41, p = .027). In conclusion, our meta-analysis showed that CSF IL-10 is an effective diagnostic and prognostic biomarker for CNSL.
authors.affiliation: a Department of Hematology , Laoshan Branch of No. 401 Hospital of Chinese People's Liberation Army (PLA) , Qingdao , China.|b Department of Hematology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: b Department of Hematology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Lan
authors.initials: L
authors.lastname: Luo
authors.affiliation: b Department of Hematology , Chinese PLA General Hospital , Beijing , China.|c Department of Hematology , The Fourth Hospital of Hebei Medical University , Shijiazhuang , China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Gao
authors.affiliation: a Department of Hematology , Laoshan Branch of No. 401 Hospital of Chinese People's Liberation Army (PLA) , Qingdao , China.
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Liu
authors.affiliation: a Department of Hematology , Laoshan Branch of No. 401 Hospital of Chinese People's Liberation Army (PLA) , Qingdao , China.
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: Liu
authors.affiliation: a Department of Hematology , Laoshan Branch of No. 401 Hospital of Chinese People's Liberation Army (PLA) , Qingdao , China.
authors.forename: De-Xun
authors.initials: DX
authors.lastname: Ma
authors.affiliation: a Department of Hematology , Laoshan Branch of No. 401 Hospital of Chinese People's Liberation Army (PLA) , Qingdao , China.
authors.forename: Ji-Gang
authors.initials: JG
authors.lastname: Chen
authors.affiliation: a Department of Hematology , Laoshan Branch of No. 401 Hospital of Chinese People's Liberation Army (PLA) , Qingdao , China.
authors.forename: Wu-Rui
authors.initials: WR
authors.lastname: Cao
authors.affiliation: a Department of Hematology , Laoshan Branch of No. 401 Hospital of Chinese People's Liberation Army (PLA) , Qingdao , China.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Yin
authors.affiliation: a Department of Hematology , Laoshan Branch of No. 401 Hospital of Chinese People's Liberation Army (PLA) , Qingdao , China.
authors.forename: Jia-Wen
authors.initials: JW
authors.lastname: Xu
authors.affiliation: a Department of Hematology , Laoshan Branch of No. 401 Hospital of Chinese People's Liberation Army (PLA) , Qingdao , China.
authors.forename: Song-Lei
authors.initials: SL
authors.lastname: Wang
authors.affiliation: a Department of Hematology , Laoshan Branch of No. 401 Hospital of Chinese People's Liberation Army (PLA) , Qingdao , China.
authors.forename: Du-Jun
authors.initials: DJ
authors.lastname: Zhuo
authors.affiliation: a Department of Hematology , Laoshan Branch of No. 401 Hospital of Chinese People's Liberation Army (PLA) , Qingdao , China.
authors.forename: Bin
authors.initials: B
authors.lastname: Geng
authors.affiliation: b Department of Hematology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Sha-Sha
authors.initials: SS
authors.lastname: Zhao
authors.affiliation: b Department of Hematology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Fei-Yan
authors.initials: FY
authors.lastname: Wang
authors.affiliation: b Department of Hematology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Nan
authors.initials: N
authors.lastname: Yang
authors.affiliation: b Department of Hematology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Li-Xun
authors.initials: LX
authors.lastname: Guan
authors.affiliation: b Department of Hematology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Zhen-Yang
authors.initials: ZY
authors.lastname: Gu
authors.affiliation: b Department of Hematology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Chun-Ji
authors.initials: CJ
authors.lastname: Gao
mesh_terms: D016543:Central Nervous System Neoplasms / Q000134:cerebrospinal fluid / Q000175:diagnosis; D006801:Humans; D016753:Interleukin-10 / Q000134:cerebrospinal fluid; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D016753:Interleukin-10
keywords: Cerebrospinal fluid; central nervous system lymphoma; diagnosis; interleukin-10; meta-analysis; prognosis