title: Abscisic acid-type sesquiterpenes and ansamycins from Amycolatopsis alba DSM 44262.
abstract: Two new abscisic acid-type sesquiterpenes (1, 2), and one new ansamycin (3), together with four known ansamycins, namely ansacarbamitocins 4-7, were isolated from the fermentation extract of Amycolatopsis alba DSM 44262. The structures of the new compounds were elucidated to be (E)-3-methyl-5-(2,6,6-trimethyl-3-oxocyclohex-1-enyl)pent-2-enoic acid (1) and (E)-3-methyl-5-(2,6,6-trimethyl-4-oxocyclohex-2-enyl)pent-2-enoic acid (2), and 9-O-methylansacarbamitocin A1 (3), on the basis of comprehensive analysis of spectroscopic data, respectively. The antimicrobial activities were also evaluated for all seven compounds.
authors.affiliation: a Key Laboratory of Chemical Biology (Ministry of Education) , School of Pharmaceutical Sciences, Shandong University , Jinan , China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: a Key Laboratory of Chemical Biology (Ministry of Education) , School of Pharmaceutical Sciences, Shandong University , Jinan , China.
authors.forename: Xiao-Man
authors.initials: XM
authors.lastname: Li
authors.affiliation: a Key Laboratory of Chemical Biology (Ministry of Education) , School of Pharmaceutical Sciences, Shandong University , Jinan , China.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Lu
mesh_terms: D000040:Abscisic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000192:Actinomycetales / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005229:Fatty Acids, Monounsaturated; D047029:Lactams, Macrocyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D005229:Fatty Acids, Monounsaturated; D047029:Lactams, Macrocyclic; D012717:Sesquiterpenes; C005476:pent-2-enoic acid; D000040:Abscisic Acid
keywords: Amycolatopsis alba DSM 44262; ansacarbamitocins; ansamycins; antimicrobial activity; sesquiterpenes