title: The Neutrophil-Lymphocyte Ratio Is Associated with Coronary Artery Calcification in Asymptomatic Korean Males: A Cross-Sectional Study.
abstract: Introduction. The neutrophil-lymphocyte ratio (NLR) is a significant systemic predictor of cardiovascular disease (CVD). The coronary artery calcium score (CACS) reflects coronary artery calcification and is an independent risk factor for coronary artery stenosis. In the present study, we explored the relationship between the NLR and CACS in terms of subclinical inflammation and coronary artery calcification.Materials and Methods. We evaluated males and females who did not have CVD, diabetes, high blood pressure, or high fasting blood sugar levels. We measured white blood cell, neutrophil, lymphocyte counts, fasting blood sugar, total cholesterol, high-density lipoprotein cholesterol, triglycerides (TG), and high-sensitivity C-reactive protein levels in blood samples. We also obtained CACSs using coronary multidetector computed tomography.Results. Multivariate logistic regression showed that older age was significantly associated with a higher CACS (P< 0.001); males had higher CACSs than females (P< 0.001); and the higher the TG level, the higher the CACS (P= 0.019). The NLR of males, but not females, was significantly associated with the CACS.Conclusion. An independent association between the NLR and CACS was thus evident in healthy adult males after adjusting for other CVD risk factors. Therefore, the NLR is a significant predictor of potential CVD in male subjects with subclinical atherosclerosis.
authors.affiliation: Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
authors.forename: Su-Hyun
authors.initials: SH
authors.lastname: Nam
authors.affiliation: Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
authors.forename: Sung-Goo
authors.identifier: 0000-0003-4627-291X
authors.initials: SG
authors.lastname: Kang
authors.affiliation: Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea; Health Promotion Center, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
authors.forename: Sang-Wook
authors.identifier: 0000-0001-9087-5019
authors.initials: SW
authors.lastname: Song
mesh_terms: D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000097:blood / Q000453:epidemiology; D003331:Coronary Vessels / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000473:pathology*; D016017:Odds Ratio; D012372:ROC Curve; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D061205:Vascular Calcification / Q000097:blood* / Q000453:epidemiology