title: Effects of aging on action-intentional programming.
abstract: Action-intentional programs control "when" we initiate, inhibit, continue, and stop motor actions. The purpose of this study was to learn if there are changes in the action-intentional system with healthy aging, and if these changes are asymmetrical (right versus left upper limb) or related to impaired interhemispheric communication.
  
  
  
  We administered tests of action-intention to 41 middle-aged and older adults (61.9 ± 12.3 years).
  
  
  
  Regression analyses revealed that older age predicted a decrement in performance for tests of crossed motor response inhibition as well as slower motor initiation with the left hand.
  
  
  
  Changes in action-intention with aging appear to be related to alterations of interhemispheric communication and/or age-related right hemisphere dysfunction; however, further research is needed to identify the mechanisms for age-related changes in the brain networks that mediate action-intention.
authors.affiliation: b Geriatric Research Education and Clinical Center of the Malcom Randall Veterans Affairs Medical Center , Gainesville , FL , USA.|c Department of Neurology and Center for Neuropsychological Studies , University of Florida , Gainesville , FL , USA.
authors.forename: Ali R
authors.initials: AR
authors.lastname: Shoraka
authors.affiliation: b Geriatric Research Education and Clinical Center of the Malcom Randall Veterans Affairs Medical Center , Gainesville , FL , USA.
authors.forename: Dana M
authors.initials: DM
authors.lastname: Otzel
authors.affiliation: c Department of Neurology and Center for Neuropsychological Studies , University of Florida , Gainesville , FL , USA.
authors.forename: Eduardo
authors.initials: E
authors.lastname: M Zilli
authors.affiliation: c Department of Neurology and Center for Neuropsychological Studies , University of Florida , Gainesville , FL , USA.
authors.forename: Glen R
authors.initials: GR
authors.lastname: Finney
authors.affiliation: c Department of Neurology and Center for Neuropsychological Studies , University of Florida , Gainesville , FL , USA.|d Florida Department of Elder Affairs , Alzheimer's Disease Initiative, University of Florida Cognitive and Memory Disorder Clinics , Gainesville , FL , USA.|e National Institutes of Health/National Institute of Aging, 1Florida ADRC (Alzheimer's Disease Research Center) , Gainesville , FL , USA.
authors.forename: Leilani
authors.initials: L
authors.lastname: Doty
authors.affiliation: a Brain Rehabilitation Research Center of the Malcom Randall Veterans Affairs Medical Center , Gainesville , FL , USA.|c Department of Neurology and Center for Neuropsychological Studies , University of Florida , Gainesville , FL , USA.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Falchook
authors.affiliation: a Brain Rehabilitation Research Center of the Malcom Randall Veterans Affairs Medical Center , Gainesville , FL , USA.|b Geriatric Research Education and Clinical Center of the Malcom Randall Veterans Affairs Medical Center , Gainesville , FL , USA.|c Department of Neurology and Center for Neuropsychological Studies , University of Florida , Gainesville , FL , USA.|d Florida Department of Elder Affairs , Alzheimer's Disease Initiative, University of Florida Cognitive and Memory Disorder Clinics , Gainesville , FL , USA.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Heilman
mesh_terms: D000328:Adult; D000368:Aged; D000066492:Cognitive Aging; D005260:Female; D006225:Hand; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D011597:Psychomotor Performance
keywords: Cognitive aging; action-intention; brain aging; interhemispheric disconnection; motor control