title: Synthesis of Pyrrolidinium-Type Poly(ionic liquid) Membranes for Antibacterial Applications.
abstract: Pyrrolidinium-type small molecule ionic liquids (ILs), poly(ionic liquid) (PIL) homopolymers, and their corresponding PIL membranes were synthesized and used for antibacterial applications. The influences of substitutions at the N position of pyrrolidinium cation on the antimicrobial activities against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were studied by minimum inhibitory concentration (MIC). The antibacterial efficiency of both the small molecule ILs and PIL homopolymers increased with the increase of the alkyl chain length of substitutions. Furthermore, PIL homopolymers show relatively lower MIC values, indicating better antimicrobial activities than those of the corresponding small molecule ILs. However, the antibacterial properties of the PIL membranes are contrary to corresponding ILs and PIL homopolymers, which reduce with the increase of alkyl chain length. Furthermore, the resultant PIL membranes show excellent hemocompatibility and low cytotoxicity toward human cells, demonstrating clinical feasibility in topical applications.
authors.affiliation: Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
authors.forename: Jing
authors.identifier: http://orcid.org/0000-0003-1407-9074
authors.initials: J
authors.lastname: Qin
authors.affiliation: Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
authors.forename: Jiangna
authors.identifier: http://orcid.org/0000-0002-4052-252X
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Zhongshan Hospital, Fudan University , Shanghai 200032, China.
authors.forename: Qiming
authors.identifier: http://orcid.org/0000-0001-7762-1794
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
authors.forename: Zhiqiang
authors.identifier: http://orcid.org/0000-0001-7973-7985
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Zhongshan Hospital, Fudan University , Shanghai 200032, China.
authors.forename: Hailei
authors.identifier: http://orcid.org/0000-0003-2999-7142
authors.initials: H
authors.lastname: Mao
authors.affiliation: Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
authors.forename: Feng
authors.identifier: http://orcid.org/0000-0001-9269-7025
authors.initials: F
authors.lastname: Yan
mesh_terms: D000900:Anti-Bacterial Agents; D004926:Escherichia coli; D006801:Humans; D052578:Ionic Liquids / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus
chemical_list: D000900:Anti-Bacterial Agents; D052578:Ionic Liquids
keywords: antibacterial materials; cytotoxicity; poly(ionic liquid)s; polymer membranes; pyrrolidinium cations