title: When potion becomes poison! A case report of flecainide toxicity.
abstract: We report a 48-day-old female infant, who developed cardiac conduction abnormalities and seizures secondary to supratherapeutic doses of oral flecainide. Flecainide was started in this infant for treatment of supraventricular tachycardia. The drug was withdrawn with successful normalization of the QRS complex and no further recurrence of seizures. The Naranjo probability score for adverse drug reaction was 8, making the causality "probable." The case restates an important message that physicians should be aware of the side effects of the drugs that they prescribe, especially of those drugs which have a narrow therapeutic window.
authors.affiliation: Department of Pediatrics, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.
authors.forename: S
authors.initials: S
authors.lastname: Bajaj
authors.affiliation: Department of Pediatrics, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.
authors.forename: M S
authors.initials: MS
authors.lastname: Tullu
authors.affiliation: Department of Pediatrics, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.
authors.forename: Zah
authors.initials: Z
authors.lastname: Khan
authors.affiliation: Department of Pediatrics, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.
authors.forename: M
authors.initials: M
authors.lastname: Agrawal
mesh_terms: D000284:Administration, Oral; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000097:blood / Q000506:poisoning*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D000075224:Cardiac Conduction System Disease / Q000139:chemically induced*; D064420:Drug-Related Side Effects and Adverse Reactions; D004562:Electrocardiography; D005260:Female; D005424:Flecainide / Q000008:administration & dosage* / Q000097:blood / Q000506:poisoning*; D006801:Humans; D007223:Infant; D012640:Seizures / Q000209:etiology*; D013617:Tachycardia, Supraventricular / Q000097:blood / Q000188:drug therapy*
chemical_list: D000889:Anti-Arrhythmia Agents; D005424:Flecainide