title: Variations of renal tissue oxygenation during abdominal compartment syndrome and sepsis.
abstract: OBJECTIVE
  This experimental study was designed to evaluate the renal tissue oxygenation under the coexistence of abdominal compartment syndrome and sepsis.
  
  
  METHODS
  Fourteen non-breed dogs were divided into two groups: the control group (8) and the study group (6). Sepsis was established with intravenous endotoxin infusion at 100μg/kg for over 30min. Insufflation of CO2in the peritoneal cavity was used for the increase in intra-abdominal pressure (IAP). A special catheter placed and fixed in the renal cortex at a depth of 3mm from the renal capsule was used for the measurement of renal tissue oxygenation.
  
  
  RESULTS
  Study parameters were recorded at the starting phase, at IAP of 15mmHg and 30mmHg and after decompression of the abdomen in the control group, and at the same intervals plus the induction of sepsis, prior to increasing abdominal pressure, in the study group. With the elevation of the IAP a reduction of renal tissue oxygenation presents itself, which is more pronounced in the presence of sepsis, especially for IAP over 15mmHg. Like other parameters, after abdominal decompression the renal tissue oxygenation returns to the initial levels, independently of sepsis.
  
  
  CONCLUSIONS
  The afferent arterioles vasoconstriction, which takes place during sepsis, and the intra-renal shunt, which occurs and leads to blood diversion to the medulla from the renal cortex due to the combination of intra-abdominal hypertension (IAH) and sepsis, seem to explain this finding.
authors.affiliation: Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Kalfadis
authors.affiliation: Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Vaia
authors.initials: V
authors.lastname: Nalbanti
authors.affiliation: Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address: telonakos@hotmail.com.
authors.forename: Orestis
authors.initials: O
authors.lastname: Ioannidis
authors.affiliation: Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Porfiriou
authors.affiliation: Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Botsios
authors.affiliation: Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Tsalis
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism*; D004285:Dogs; D005260:Female; D059325:Intra-Abdominal Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D018805:Sepsis / Q000503:physiopathology*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen
keywords: Abdominal perfusion pressure; Abdominal pressure; Intra-abdominal hypertension; Partial carbon dioxide pressure; Partial oxygen pressure