title: Acute infections caused by Tropheryma whipplei.
abstract: Tropheryma whipplei is the causative bacterium of Whipple's disease. Its first culture has led to an enlargement of the field of the caused infections. Here, we comprehensively review acute T. whipplei infections. In a cohort study featuring 4000 children, T. whipplei was significantly more common in patients with diarrhea (4%) than in those without (1.7%). A case-controlled study highlighted 58 patients suffering from pneumonia with the detection of T. whipplei in their bronchoalveolar fluids. Finally, a recent study detected T. whipplei in the blood of 36 febrile patients experiencing pulmonary symptoms in a rural area of Senegal. T. whipplei is definitively an agent of acute gastroenteritis, a cause of nonmalarial fever in Africa, and probably a cause of pulmonary infections.
authors.affiliation: Aix Marseille Université, URMITE, IHU Méditerranée-Infection, UM63, CNRS 7278, IRD 198, INSERM 1095, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Lagier
authors.affiliation: Aix Marseille Université, URMITE, IHU Méditerranée-Infection, UM63, CNRS 7278, IRD 198, INSERM 1095, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Fenollar
authors.affiliation: Aix Marseille Université, URMITE, IHU Méditerranée-Infection, UM63, CNRS 7278, IRD 198, INSERM 1095, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
mesh_terms: D000208:Acute Disease; D005759:Gastroenteritis / Q000382:microbiology; D006801:Humans; D054851:Tropheryma / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D008061:Whipple Disease / Q000382:microbiology*
keywords: Tropheryma whipplei; gastroenteritis; pneumonia