title: Angiomodulators in cancer therapy: New perspectives.
abstract: The formation of new blood vessels plays a crucial for the development and progression of pathophysiological changes associated with a variety of disorders, including carcinogenesis. Angiogenesis inhibitors (anti-angiogenics) are an important part of treatment for some types of cancer. Some natural products isolated from marine invertebrates have revealed antiangiogenic activities, which are diverse in structure and mechanisms of action. Many preclinical studies have generated new models for further modification and optimization of anti-angiogenic substances, and new information for mechanistic studies and new anti-cancer drug candidates for clinical practice. Moreover, in the last decade it has become apparent that galectins are important regulators of tumor angiogenesis, as well as microRNA. MicroRNAs have been validated to modulate endothelial cell migration or endothelial tube organization. In the present review we summarize the current knowledge regarding the role of marine-derived natural products, galectins and microRNAs in tumor angiogenesis.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia.
authors.forename: Lenka
authors.initials: L
authors.lastname: Varinska
authors.affiliation: Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia; Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. Electronic address: kubatka@jfmed.uniba.sk.
authors.forename: Peter
authors.initials: P
authors.lastname: Kubatka
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia.
authors.forename: Jan
authors.initials: J
authors.lastname: Mojzis
authors.affiliation: The Centre for Chronic Disease, College of Health & Biomedicine, Victoria University, Melbourne, Werribee Campus, Victoria, Australia.
authors.forename: Anthony
authors.initials: A
authors.lastname: Zulli
authors.affiliation: Department of Nutrition, Faculty of Nursing and Professional Health Studies, Slovak Medical University, Bratislava, Slovak Republic; Department of General Medicine, Faculty of Medicine, Slovak Medical University, Bratislava, Slovak Republic. Electronic address: katarina.gazdikova@szu.sk.
authors.forename: Katarina
authors.initials: K
authors.lastname: Gazdikova
authors.affiliation: Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia; Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
authors.forename: Pavol
authors.initials: P
authors.lastname: Zubor
authors.affiliation: Weill Cornell Medicine in Qatar, Qatar Foundation-Education City, Doha, Qatar.
authors.forename: Dietrich
authors.initials: D
authors.lastname: Büsselberg
authors.affiliation: 2nd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors.forename: Martin
authors.initials: M
authors.lastname: Caprnda
authors.affiliation: Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho tr. 1/1946, 612 42 Brno, Czechia.
authors.forename: Radka
authors.initials: R
authors.lastname: Opatrilova
authors.affiliation: Institute of Biology, Genetics and Medical Genetics, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovak Republic.
authors.forename: Iveta
authors.initials: I
authors.lastname: Gasparova
authors.affiliation: Department of Haemato-Oncology and Department of Internal Medicine - Cardiology, Faculty of Medicine, Palacky University, Olomouc, Czechia.
authors.forename: Martin
authors.initials: M
authors.lastname: Klabusay
authors.affiliation: Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
authors.forename: Martin
authors.initials: M
authors.lastname: Pec
authors.affiliation: Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Eitan
authors.initials: E
authors.lastname: Fibach
authors.affiliation: Department of Thoracic Surgery, Faculty of Medicine and Dentistry, Medical University of Silesia, Katowice, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Adamek
authors.affiliation: Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho tr. 1/1946, 612 42 Brno, Czechia. Electronic address: kruzliakpeter@gmail.com.
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D043924:Angiogenesis Modulating Agents / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001688:Biological Products / Q000494:pharmacology; D037161:Galectins / Q000187:drug effects; D006801:Humans; D008387:Marine Toxins / Q000494:pharmacology; D035683:MicroRNAs / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D020533:Angiogenesis Inhibitors; D043924:Angiogenesis Modulating Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D037161:Galectins; D008387:Marine Toxins; D035683:MicroRNAs
keywords: Angiogenesis; Anti-angiogenics; Cancer therapy; Galectins; Marine natural products; microRNAs