title: Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity.
abstract: Using various chromatographic methods, five new sesquiterpene derivatives named smenohaimiens A-E (1-5) and five known, 19-hydroxy-polyfibrospongol B (6), ilimaquinone (7), dictyoceratin C (8), polyfibrospongol A (9), and polyfibrospongol B (10) were isolated from the marine sponge Smenospongia cerebriformis Duchassaing & Michelotti, 1864. Their structures were assigned by 1D, 2D NMR spectroscopic analysis, HR ESI MS, and calculations of the electron circular dichroism spectra. All compounds were evaluated for the inhibitory activity against NO production in lipopolysaccharide-stimulated in BV2 microglia cells. As the results, compound 7 significantly inhibited NO production with the IC50value of 10.40±1.28µM. The remaining compounds showed moderate inhibitory NO production activities with IC50values ranging from 24.37 to 30.43µM.
authors.affiliation: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: phankiem@yahoo.com.
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.affiliation: Faculty of Chemistry, VNU University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi, Viet Nam.
authors.forename: Le Thi
authors.initials: LT
authors.lastname: Huyen
authors.affiliation: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
authors.forename: Dan Thuy
authors.initials: DT
authors.lastname: Hang
authors.affiliation: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.affiliation: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.affiliation: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
authors.forename: Hoang Le Tuan
authors.initials: HL
authors.lastname: Anh
authors.affiliation: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
authors.forename: Pham Van
authors.initials: PV
authors.lastname: Cuong
authors.affiliation: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
authors.forename: Tran Hong
authors.initials: TH
authors.lastname: Quang
authors.affiliation: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
authors.affiliation: Faculty of Chemistry, VNU University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi, Viet Nam.
authors.forename: Nguyen Van
authors.initials: NV
authors.lastname: Dau
authors.affiliation: Korea Institute of Ocean Science & Technology, Ansan 15627, Republic of Korea.
authors.forename: Young-A
authors.initials: YA
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
authors.forename: Lalita
authors.initials: L
authors.lastname: Subedi
authors.affiliation: College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon 21983, Republic of Korea. Electronic address: kimsh11@yonsei.ac.kr.
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D011161:Porifera / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013237:Stereoisomerism; D019323:omega-N-Methylarginine / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011809:Quinones; D012717:Sesquiterpenes; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; C467077:ilimaquinone
keywords: Anti-inflammation; Sesquiterpene derivative; Smenohaimiens A–E; Smenospongia cerebriformis