title: Amino-functionalized mesoporous bioactive glass for drug delivery.
abstract: An amino-functionalized mesoporous bioactive glass (N-MBG) with a high drug loading capacity and longer drug release time was successfully prepared by using 3-aminopropyltriethoxysilane (APTES) in a short-time chemical reaction. The drug release performance of an MBG and the N-MBG were studied by loading gentamicin sulfate (GS) in a simulated body fluid solution. The results showed that the surface area of the N-MBG increases to 355.01 m2g-1after amination at 80 °C for 1 h compared with that of the MBG (288.07 m2g-1). Meanwhile, the surface zeta-potential of the N-MBG charges from the original negative charge (-10.06 mV) to the positive charge (+5.30 mV). Furthermore, the GS loading rate of the N-MBG is up to 62.92 ± 2.02%, higher than that of the MBG (48.90 ± 1.71%). In addition, the N-MBG has a longer drug release period and the seven-day accumulative release from the N-MBG reached only 45.9 ± 1.8%, significantly lower than that of the MBG, 60.7 ± 2.3%. In vitro bioactivity tests suggested that the N-MBG exhibited good biological activity. In conclusion, the N-MBG with a higher loading capacity and longer drug release time can serve as a promising candidate as a drug carrier.
authors.affiliation: College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
authors.forename: Shengxiang
authors.initials: S
authors.lastname: Jiang
authors.forename: Yin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Shu
authors.forename: Zhenning
authors.initials: Z
authors.lastname: Wu
authors.forename: Weijing
authors.initials: W
authors.lastname: Cao
authors.forename: Wenxin
authors.initials: W
authors.lastname: Huang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics; D005898:Glass / Q000737:chemistry*; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D011437:Propylamines / Q000737:chemistry; D012821:Silanes / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D005839:Gentamicins; D011437:Propylamines; D012821:Silanes; C477625:amino-propyl-triethoxysilane