title: Ultrasound-Induced Magnetic Imaging of Tumors Targeted by Biofunctional Magnetic Nanoparticles.
abstract: Biofunctional magnetic nanoparticles (MNPs) have been widely applied in biomedical engineering. MNPs are used as a contrast medium in magnetic imaging. Current methods of magnetic imaging, such as magnetic particle imaging and magnetic relaxometry, use small amounts of MNPs at target points far from the surface of the patient's body; these methods always consume considerable power to produce magnetic fields of high uniformity or gradient excitations. Some drawbacks, such as a limited imaging region, imaging system shielding, and complex algorithms based on assumptions of MNP properties or environmental factors, also limit the application of MNP methods in clinics. Therefore, this work proposes an interdisciplinary methodology of ultrasound-induced magnetic imaging that lacks these drawbacks. In the proposed imaging method, magnet sets were designed with uniform magnetic fields to magnetize MNPs. Besides, magnetized MNPs are subjected to ultrasound vibrations; the motion of the MNPs induces weak induction voltages at the imaging pickup coils. The highly sensitive scanning superconducting quantum interference device biosusceptometry with three sets of ultrasound focus chips was developed to construct magnetic tomography at three depths. A phantom test showed favorable consistency between the visual photos and the magnetic images of alpha-fetoprotein antibody (anti-AFP) MNP distribution on gauzes. In animal tests, rats with liver tumors were imaged at the pre-injection and post-injection of anti-AFP MNPs. The consistent results of magnetic images and ultrasound images implied that the proposed method has high clinical potential.
authors.affiliation: Department of Surgery and Hepatitis Research Center, National Taiwan University Hospital , 100 Taipei, Taiwan.|Graduate Institute of Clinical Medicine, National Taiwan University , 100 Taipei, Taiwan.
authors.forename: Kai-Wen
authors.initials: KW
authors.lastname: Huang
authors.affiliation: Institute of Electro-Optical Science and Technology, National Taiwan Normal University , 116 Taipei, Taiwan.
authors.forename: Jen-Jie
authors.identifier: 0000-0002-7144-2637
authors.initials: JJ
authors.lastname: Chieh
authors.affiliation: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University , 300 Hsinchu, Taiwan.
authors.forename: Chih-Kuang
authors.initials: CK
authors.lastname: Yeh
authors.affiliation: Institute of Electro-Optical Science and Technology, National Taiwan Normal University , 116 Taipei, Taiwan.
authors.forename: Shu-Hsien
authors.initials: SH
authors.lastname: Liao
authors.affiliation: Institute of Electro-Optical Science and Technology, National Taiwan Normal University , 116 Taipei, Taiwan.
authors.forename: Yi-Yan
authors.initials: YY
authors.lastname: Lee
authors.affiliation: Institute of Electro-Optical Science and Technology, National Taiwan Normal University , 116 Taipei, Taiwan.
authors.forename: Pei-Yi
authors.initials: PY
authors.lastname: Hsiao
authors.affiliation: Institute of Electro-Optical Science and Technology, National Taiwan Normal University , 116 Taipei, Taiwan.
authors.forename: Wen-Chun
authors.initials: WC
authors.lastname: Wei
authors.affiliation: Institute of Electro-Optical Science and Technology, National Taiwan Normal University , 116 Taipei, Taiwan.
authors.forename: Hong-Chang
authors.initials: HC
authors.lastname: Yang
authors.affiliation: Institute of Electro-Optical Science and Technology, National Taiwan Normal University , 116 Taipei, Taiwan.
authors.forename: Herng-Er
authors.initials: HE
authors.lastname: Horng
mesh_terms: D000818:Animals; D008113:Liver Neoplasms / Q000175:diagnosis*; D060526:Magnetic Fields; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051381:Rats; D014463:Ultrasonography; D000509:alpha-Fetoproteins / Q000737:chemistry*
chemical_list: D058185:Magnetite Nanoparticles; D000509:alpha-Fetoproteins
keywords: alpha-fetoprotein; magnetic nanoparticles; superconducting quantum interference device; tumors; ultrasound-induced magnetic imaging