title: Biological and predictive role of ERCC1 polymorphisms in cancer.
abstract: Excision repair cross-complementation group 1 (ERCC1) is a key component in DNA repair mechanisms and may influence the tumor DNA-targeting effect of the chemotherapeutic agent oxaliplatin. Germline ERCC1 polymorphisms may alter the protein expression and published data on their predictive and prognostic value have so far been contradictory. In the present article we review available evidence on the clinical role and utility of ERCC1 polymorphisms and, in the absence of a 'perfect' trial, what we call the 'sliding doors' trial, we present the data of ERCC1 genotyping in our local patient population. We found a useful predictive value for oxaliplatin-induced risk of anemia.
authors.affiliation: Medical Oncology Unit, Department of Systems Medicine, Tor Vergata Clinical Center University Hospital, Rome, Italy. Electronic address: vincenzo.formica@uniroma2.it.
authors.forename: V
authors.initials: V
authors.lastname: Formica
authors.affiliation: Anatomic Pathology Institute, Department of Biomedicine and Prevention, Tor Vergata University Hospital, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Doldo
authors.affiliation: Medical Oncology Unit, Department of Systems Medicine, Tor Vergata Clinical Center University Hospital, Rome, Italy.
authors.forename: F R
authors.initials: FR
authors.lastname: Antonetti
authors.affiliation: Medical Oncology Unit, Department of Systems Medicine, Tor Vergata Clinical Center University Hospital, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Nardecchia
authors.affiliation: Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Ferroni
authors.affiliation: Medical Oncology Unit, Department of Systems Medicine, Tor Vergata Clinical Center University Hospital, Rome, Italy; Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Riondino
authors.affiliation: Medical Oncology Unit, Department of Systems Medicine, Tor Vergata Clinical Center University Hospital, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Morelli
authors.affiliation: Drug Development Unit, Sarah Cannon Research Institute, London, United Kingdom.
authors.forename: H T
authors.initials: HT
authors.lastname: Arkenau
authors.affiliation: Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Guadagni
authors.affiliation: Anatomic Pathology Institute, Department of Biomedicine and Prevention, Tor Vergata University Hospital, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Orlandi
authors.affiliation: Medical Oncology Unit, Department of Systems Medicine, Tor Vergata Clinical Center University Hospital, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Roselli
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000235:genetics; D004260:DNA Repair; D004273:DNA, Neoplasm / Q000235:genetics; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D004720:Endonucleases / Q000737:chemistry / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D051818:Replication Protein C / Q000737:chemistry / Q000235:genetics; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics
chemical_list: D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; D009944:Organoplatinum Compounds; C095385:Rfc1 protein, mouse; D014157:Transcription Factors; D000077150:Oxaliplatin; C071447:ERCC1 protein, human; D004720:Endonucleases; D051818:Replication Protein C
keywords: Colorectal cancer; ERCC1; Oxaliplatin; Single nucleotide polymorphisms