title: Retrospective analysis of primary gastric diffuse largeB-cell lymphoma: a single center study from Turkey.
abstract: Diffuse large B-cell primary gastric lymphomas (DLBC-PGLs) are treated with different therapies. Their optimal treatment is not well documented.
  
  
  
  We retrospectively analyzed the data of 51 patients diagnosed with DLBC-PGL in the previous 10 years. All patients were treated with R-CHOP as first line. Radiotherapy was added to chemotherapy in 8 patients. Surgery was performed in 5 patients.
  
  
  
  The median follow-up time of the 51 patients was 45.5 (range 5-144) months and the complete response (CR) rate was 90.2%. CR was achieved in 34 (89.4%) of 38 patients treated with single chemotherapy, in all (100%) 5 patients treated with chemotherapy plus surgery, and in 7 (87.5%) of 8 patients treated with chemotherapy plus radiotherapy. The 5-year overall survival (OS) and event-free survival (EFS) rates were 85.8% and 89.6%, respectively. The 5-year OS and EFS rates were not significantly different between patients treated with single chemotherapy or chemotherapy plus radiotherapy/surgery (P > 0.05).
  
  
  
  R-CHOP chemotherapy is as effective as R-CHOP plus radiotherapy/surgery in the treatment of DLBC-PGL patients. Prospective randomized large cohort studies are needed to generate guidelines for the treatment of DLBC-PGL.
authors.affiliation: Department of Hematology, Faculty of Medicine, Ege University, İzmir, Turkey.
authors.forename: Nur
authors.initials: N
authors.lastname: Soyer
authors.affiliation: Department of Hematology, Faculty of Medicine, Ege University, İzmir, Turkey.
authors.forename: Asu Fergün
authors.initials: AF
authors.lastname: Yilmaz
authors.affiliation: Department of Pathology, Faculty of Medicine, Ege University, İzmir, Turkey.
authors.forename: Nazan
authors.initials: N
authors.lastname: Özsan
authors.affiliation: Department of Hematology, Faculty of Medicine, Ege University, İzmir, Turkey.
authors.forename: Fahri
authors.initials: F
authors.lastname: Şahin
authors.affiliation: Department of Hematology, Faculty of Medicine, Ege University, İzmir, Turkey.
authors.forename: Güray
authors.initials: G
authors.lastname: Saydam
authors.affiliation: Department of Hematology, Faculty of Medicine, Ege University, İzmir, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Tombuloğlu
authors.affiliation: Department of Pathology, Faculty of Medicine, Ege University, İzmir, Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Hekimgil
authors.affiliation: Department of Hematology, Faculty of Medicine, Ege University, İzmir, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Vural
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D008297:Male; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D014421:Turkey / Q000453:epidemiology