title: Schizophrenia-like symptoms in a patient with Leigh syndrome.
abstract: Leigh syndrome is a mitochondrial disease characterized by subacute necrotizing encephalomyelopathy. Almost all cases of Leigh syndrome develop at infancy or early childhood and die within several years due to rapidly progressive muscle weakness and respiratory failure. Here, we present a rare case of a patient who developed Leigh syndrome associated with thiamine-responsive pyruvate dehydrogenase-complex deficiency at 2 years of age and has survived to adolescence through effective high dose thiamin therapy. At 15 years of age, the patient presented persecutory delusions and auditory hallucinations, suggesting an association between mitochondrial dysfunction and schizophrenia-like psychotic symptoms.
authors.affiliation: Department of Neuropsychiatry, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Japan. Electronic address: kazumi.s@wakayama-med.ac.jp.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Satogami
authors.affiliation: Department of Neuropsychiatry, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Japan.
authors.forename: Shun
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Department of Neuropsychiatry, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Japan; Department of Psychiatry, Wakayama Prefectural Mental Health Care Center, 31 Sho, Aridagawa Town, Arida-Gun, Wakayama, Japan.
authors.forename: Asami
authors.initials: A
authors.lastname: Kose
authors.affiliation: Department of Neuropsychiatry, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shinosaki
mesh_terms: D000293:Adolescent; D006801:Humans; D007888:Leigh Disease / Q000150:complications*; D008297:Male; D011618:Psychotic Disorders / Q000209:etiology*; D012559:Schizophrenia / Q000209:etiology
keywords: Leigh syndrome; Mitochondrial disease; Schizophrenia-like psychotic symptoms