title: Simulating the effects of growth and fiber dispersion on the electromechanical response of a cardiac ventricular wedge affected from concentric hypertrophy.
abstract: In this paper, we analyze the epicardial electromechanical response of an in silico cardiac ventricular wedge under both healthy and concentric hypertrophic conditions. This is achieved by taking into account the growth of the wedge thickness and the fiber dispersion that may follow. The electromechanical response is described in terms of some macroscopic measures, i.e. the action potential duration, the conduction velocity, the contractility and the contraction force. Our results suggest that growth reduces the action potential duration and conduction velocity, whilst it increases the contractility and contraction force, yielding an overall negative effect. In presence of fiber dispersion, the action potential duration and conduction velocity are not affected further, whilst the effect on the contractility and contraction force is enhanced.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Del Bianco
authors.forename: Piero Colli
authors.initials: PC
authors.lastname: Franzone
authors.forename: Simone
authors.initials: S
authors.lastname: Scacchi
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Fassina
mesh_terms: D000200:Action Potentials; D018780:Body Surface Potential Mapping / Q000379:methods*; D006321:Heart; D006329:Heart Conduction System / Q000502:physiology*; D006352:Heart Ventricles; D006801:Humans; D006984:Hypertrophy; D009119:Muscle Contraction