title: The association of environmental, individual factors, and dopamine pathway gene variation with smoking cessation.
abstract: This study aimed to examine whether dopamine (DA) pathway gene variation were associated with smoking cessation, and compare the relative importance of infulence factors on smoking cessation. Participants were recruited from 17 villages of Shandong Province, China. Twenty-five single nucleotide polymorphisms in 8 DA pathway genes were genotyped. Weighted gene score of each gene was used to analyze the whole gene effect. Logistic regression was used to calculate odds ratios (OR) of the total gene score for smoking cessation. Dominance analysis was employed to compare the relative importance of individual, heaviness of smoking, psychological and genetic factors on smoking cessation. 415 successful spontaneous smoking quitters served as the cases, and 404 unsuccessful quitters served as the controls. A significant negative association of total DA pathway gene score and smoking cessation was observed (p < 0.001, OR: 0.25, 95% CI 0.16-0.38). Dominance analysis showed that the most important predictor for smoking cessation was heaviness of smoking score (42%), following by individual (40%), genetic (10%) and psychological score (8%). In conclusion, although the DA pathway gene variation was significantly associated with successful smoking cessation, heaviness of smoking and individual factors had bigger effect than genetic factors on smoking cessation.
authors.affiliation: a Department of Epidemiology , School of Public Health, Shandong University , Jinan , P.R. China.
authors.forename: Suyun
authors.initials: S
authors.lastname: Li
authors.affiliation: a Department of Epidemiology , School of Public Health, Shandong University , Jinan , P.R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: b Hebei Province Center for Disease Control and Prevention , Shijiazhuang , P.R. China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Pan
authors.affiliation: a Department of Epidemiology , School of Public Health, Shandong University , Jinan , P.R. China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Yang
authors.affiliation: a Department of Epidemiology , School of Public Health, Shandong University , Jinan , P.R. China.
authors.forename: Huijie
authors.initials: H
authors.lastname: Li
authors.affiliation: a Department of Epidemiology , School of Public Health, Shandong University , Jinan , P.R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Jiang
authors.affiliation: a Department of Epidemiology , School of Public Health, Shandong University , Jinan , P.R. China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: a Department of Epidemiology , School of Public Health, Shandong University , Jinan , P.R. China.
authors.forename: Mingkui
authors.initials: M
authors.lastname: Han
authors.affiliation: a Department of Epidemiology , School of Public Health, Shandong University , Jinan , P.R. China.
authors.forename: Chongqi
authors.initials: C
authors.lastname: Jia
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D004298:Dopamine / Q000235:genetics* / Q000502:physiology*; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007206:Individuality; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012907:Smoking / Q000235:genetics* / Q000523:psychology; D016540:Smoking Cessation / Q000523:psychology*; D012931:Social Environment; D013223:Statistics as Topic
chemical_list: D004298:Dopamine
keywords: Successful smoking cessation; dominance analysis; dopamine pathway gene; gene score