title: The effects of zoledronic acid treatment on depression and quality of life in women with postmenopausal osteoporosis: A clinical trial study.
abstract: BACKGROUND
  Osteoporosis affects quality of life (QoL) and may lead to depression in women. The purpose of this study was to evaluate the effects of zoledronic acid (ZA) treatment on depression and QoL in women with postmenopausal osteoporosis (PO).
  
  
  METHODS
  A total of 88 newly diagnosed women with PO were included in this study. All patients were treated with once-yearly ZA (5 mg). A QoL questionnaire from the European Foundation for Osteoporosis and Beck Depression Inventory were given to patients at baseline and at 12 months. The results for baseline and post - 12thmonth were compared, and bone mineral density (BMD) levels were compared.
  
  
  RESULTS
  The consumption of once-yearly ZA (5 mg) treatment increases BMD at levels of lumbers 1-4 (P= 0.026), total Hip T score'sPvalue is same as femoral neck (P: 0,033). ZA 5 mg treatment also improved QoL (P= 0.001) and reduced depression (P= 0.001).
  
  
  CONCLUSIONS
  ZA treatment increases BMD levels and QoL while reducing depression. Once-yearly ZA (5 mg) may be considered for postmenopausal women as a first-line treatment.
authors.affiliation: Department of Endocrinology, Sakarya University Research and Training Hospital, Sakarya, Turkey.
authors.forename: Feyzi
authors.initials: F
authors.lastname: Gokosmanoglu
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Varim
authors.affiliation: Department of Endocrinology, Faculty of Medicine, Ondokuz University, Samsun, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Atmaca
authors.affiliation: Department of Endocrinology, Faculty of Medicine, Ondokuz University, Samsun, Turkey.
authors.forename: Mehmet Hulusi
authors.initials: MH
authors.lastname: Atmaca
authors.affiliation: Department of Endocrinology, Faculty of Medicine, Ondokuz University, Samsun, Turkey.
authors.forename: Ramis
authors.initials: R
authors.lastname: Colak
keywords: Depression; osteoporosis; quality of life