title: Reversal of isolated 20q deletion with vitamin B12replacement in a patient with pernicious anaemia.
abstract: Severe vitamin B12deficiency is well known to cause morphological alterations in bone marrow. In rare instances, these myelodysplastic and megaloblastic changes can coexist with cytogenetic abnormalities. Here, we report a case of a 38-year-old African-American woman with pernicious anaemia, who was found to have an isolated 20q deletion and which resolved after vitamin B12replacement. We also discuss various mechanisms in which vitamin B12deficiency can lead to chromosomal abnormalities. A literature review is also performed to evaluate various other chromosomal aberrations associated with B12deficiency.
authors.affiliation: Department of Internal Medicine, Louisiana State University Health Sciences Center- Shreveport, LA, USA.
authors.forename: Shashank Reddy
authors.initials: SR
authors.lastname: Cingam
authors.affiliation: Department of Internal Medicine, Louisiana State University Health Sciences Center- Shreveport, LA, USA.|Division of Hematology and Oncology, Louisiana State University Health Sciences Center-Shreveport, LA, USA.
authors.forename: Nebu
authors.initials: N
authors.lastname: Koshy
authors.affiliation: Department of Pathology, Louisiana State University Health Sciences Center-Shreveport, LA, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Veillon
authors.affiliation: Department of Internal Medicine, Louisiana State University Health Sciences Center- Shreveport, LA, USA.|Division of Hematology and Oncology, Louisiana State University Health Sciences Center-Shreveport, LA, USA.
authors.forename: Prakash
authors.initials: P
authors.lastname: Peddi
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics; D000752:Anemia, Pernicious / Q000188:drug therapy* / Q000235:genetics; D002872:Chromosome Deletion; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D014805:Vitamin B 12