title: Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation.
abstract: BACKGROUND
  Selenium (Se) is an essential micronutrient trace element and an established nutritional antioxidant. Low Se status exacerbates inflammatory bowel diseases progression, which involves hyper inflammation in the digestive tract. Se nanoparticles (SeNPs) exhibit anti-inflammatory activity accompanied by low toxicity, especially when decorated with natural biological compounds. Herein, we explored the beneficial effects of SeNPs decorated with Ulva lactuca polysaccharide (ULP) in mice subjected to the acute colitis model.
  
  
  RESULTS
  We constructed SeNPs coated with ULP (ULP-SeNPs) in average diameter ~130 nm and demonstrated their stability and homogeneity. Supplementation with ULP-SeNPs (0.8 ppm Se) resulted in a significant protective effect on DSS-induced acute colitis in mice including mitigation of body weight loss, and colonic inflammatory damage. ULP-SeNPs ameliorated macrophage infiltration as evidenced by decreased CD68 levels in colon tissue sections. The anti-inflammatory effects of ULP-SeNPs were found to involve modulation of cytokines including IL-6 and TNF-α. Mechanistically, ULP-SeNPs inhibited the activation of macrophages by suppressing the nuclear translocation of NF-κB, which drives the transcription of these pro-inflammatory cytokines.
  
  
  CONCLUSIONS
  ULP-SeNPs supplementation may offer therapeutic potential for reducing the symptoms of acute colitis through its anti-inflammatory actions.
authors.affiliation: School of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong Province, China.|College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong Province, China.
authors.forename: Chenghui
authors.initials: C
authors.lastname: Zhu
authors.affiliation: School of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong Province, China.
authors.forename: Shuimei
authors.initials: S
authors.lastname: Zhang
authors.affiliation: School of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong Province, China.
authors.forename: Chengwei
authors.initials: C
authors.lastname: Song
authors.affiliation: School of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong Province, China.
authors.forename: Yibo
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong Province, China.
authors.forename: Qinjie
authors.initials: Q
authors.lastname: Ling
authors.affiliation: School of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong Province, China.|Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Hoffmann
authors.affiliation: School of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong Province, China.|College of Chemistry and Material Science, Jinan University, Guangzhou, 510632, Guangdong Province, China.
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Chen
authors.affiliation: School of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong Province, China. tzhwj@jnu.edu.cn.|College of Chemistry and Material Science, Jinan University, Guangzhou, 510632, Guangdong Province, China. tzhwj@jnu.edu.cn.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zheng
authors.affiliation: School of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong Province, China. thsh@jnu.edu.cn.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Huang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use*; D003092:Colitis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D003106:Colon / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000276:immunology*; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D011134:Polysaccharides / Q000737:chemistry / Q000627:therapeutic use*; D012643:Selenium / Q000737:chemistry / Q000627:therapeutic use*; D044445:Ulva / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D016328:NF-kappa B; D011134:Polysaccharides; D012643:Selenium
keywords: Inflammatory bowel diseases (IBD); Nuclear factor κ-B (NF-κB); Selenium (Se); Selenium nanoparticles (SeNPs); Ulva lactuca polysaccharide (ULP)