title: Bringing a Leukemic Stem Cell Gene Signature into Clinics: Are We There Yet?
abstract: Prognostic markers that capture leukemia stem cell (LSC) activity can be useful for the risk stratification of acute myeloid leukemia (AML) patients. In a recent issue of Nature, Ng et al. (2016) develop a prognostic score based on a 17-gene expression signature of LSCs to predict outcome in AML patients.
authors.affiliation: The Leucegene Project at the Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3C 3J7, Canada; Banque de Cellules Leucémiques du Quebec, Maisonneuve-Rosemont Hospital, Montréal, QC H1T 2M4, Canada.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Richard-Carpentier
authors.affiliation: The Leucegene Project at the Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3C 3J7, Canada; Division of Hematology, Maisonneuve-Rosemont Hospital, Montréal, QC H1T 2M4, Canada; Banque de Cellules Leucémiques du Quebec, Maisonneuve-Rosemont Hospital, Montréal, QC H1T 2M4, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, QC H3T 1J4, Canada. Electronic address: guy.sauvageau@umontreal.ca.
authors.forename: Guy
authors.initials: G
authors.lastname: Sauvageau
mesh_terms: D000208:Acute Disease; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D014411:Neoplastic Stem Cells; D059467:Transcriptome