title: Biodegradable Cable-Tie Rapamycin-eluting Stents.
abstract: "Cable-tie" type biodegradable stents with drug-eluting nanofiber were developed to treat rabbit denuded arteries in this study. Biodegradable stents were fabricated using poly-L-lactide film following being cut and rolled into a cable-tie type stent. Additionally, drug-eluting biodegradable nanofiber tubes were electrospun from a solution containing poly (lactic-co-glycolic acid), rapamycin, and hexafluoroisopropanol, and then mounted onto the stents. The fabricated rapamycin-eluting cable-tie stents exhibited excellent mechanical properties on evaluation of compression test and collapse pressure, and less than 8% weight loss following being immersed in phosphate-buffered saline for 16 weeks. Furthermore, the biodegradable stents delivered high rapamycin concentrations for over 4 weeks and achieved substantial reductions in intimal hyperplasia associated with elevated heme oxygenase-1 and calponin level on the denuded rabbit arteries during 6 months of follow-up. The drug-eluting cable-tie type stents developed in this study might have high potential impacts for the local drug delivery to treat various vascular diseases.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taipei, Taiwan.
authors.forename: Cheng-Hung
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taipei, Taiwan.
authors.forename: Ming-Jer
authors.initials: MJ
authors.lastname: Hsieh
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taipei, Taiwan.
authors.forename: Shang-Hung
authors.initials: SH
authors.lastname: Chang
authors.affiliation: Department of Mechanical Engineering, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Chang-Lin
authors.initials: CL
authors.lastname: Chiang
authors.affiliation: Department of Mechanical Engineering, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Ching-Lung
authors.initials: CL
authors.lastname: Fan
authors.affiliation: Department of Mechanical Engineering, Chang Gung University, Taoyuan, Taiwan. shihjung@mail.cgu.edu.tw.|Department of Orthopedic Surgery, Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan. shihjung@mail.cgu.edu.tw.
authors.forename: Shih-Jung
authors.initials: SJ
authors.lastname: Liu
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taipei, Taiwan.
authors.forename: Wei-Jan
authors.initials: WJ
authors.lastname: Chen
authors.affiliation: Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan.
authors.forename: Chao-Jan
authors.initials: CJ
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan.
authors.forename: Ming-Yi
authors.initials: MY
authors.lastname: Hsu
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taipei, Taiwan.
authors.forename: Kuo-Chun
authors.initials: KC
authors.lastname: Hung
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taipei, Taiwan.
authors.forename: Chung-Chuan
authors.initials: CC
authors.lastname: Chou
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taipei, Taiwan.
authors.forename: Po-Cheng
authors.initials: PC
authors.lastname: Chang
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D054855:Drug-Eluting Stents; D004867:Equipment Design; D051547:Heme Oxygenase-1 / Q000378:metabolism; D008297:Male; D008840:Microfilament Proteins / Q000378:metabolism; D057139:Nanofibers / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry*; D011817:Rabbits; D020123:Sirolimus / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D017539:Tunica Intima / Q000187:drug effects* / Q000378:metabolism; D015854:Up-Regulation; D000096985:Calponins
chemical_list: D002135:Calcium-Binding Proteins; D051547:Heme Oxygenase-1; D008840:Microfilament Proteins; D011091:Polyesters; D020123:Sirolimus; D000096985:Calponins; C033616:poly(lactide)