title: Mean platelet volume/platelet count ratio as a predictor of 90-day outcome in large artery atherosclerosis stroke patients.
abstract: OBJECTIVE
  Previous studies reported a lower platelet count (PC) level and a higher mean platelet volume (MPV) level in severe ischemic stroke. We define MPV/PC as the platelet ratio (PR). This study investigates the relationship between PR and 90-day outcome of large artery atherosclerosis (LAA) stroke.
  
  
  METHODS
  A retrospective analysis was conducted on 338 LAA patients in two hospitals by looking up the electronic medical record (EMR). The 90-day functional outcome was divided into good and poor according to the modified Rankin Scale (mRS) score.
  
  
  RESULTS
  Multivariate logistic regression analysis of the First Affiliated Hospital of Wenzhou Medical University (Hospital 1) revealed that PR (OR1.083, 95%CI [1.044, 1.123], P < 0.001) and National Institutes of Health Stroke Scale (NIHSS) score were independent predictors of the poor outcome. Analysis from the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University (Hospital 2) showed that PR (OR1.071, 95%CI [1.039, 1.104], P < 0.001), NIHSS score and age were independent adverse prognostic predictors. Furthermore, higher quartiles of PR presented an incremental OR value compared to the first quartile PR in multivariate regression. In Hospital 1, the cut-off value of PR to predict 90-day outcome was 39.23 (sensitivity: 74.24%, specificity: 55.17%, area under the curve (AUC): 0.694, P < 0.001). In Hospital 2, the optimal cut-off value of PR was 46.08 (sensitivity: 61.40%, specificity: 73.74%, AUC: 0.695, P < 0.001).
  
  
  CONCLUSIONS
  Platelet ratio on admission is an independent predictor for 90-day outcome in LAA stroke patients and it has a good predictive effect.
authors.affiliation: a Department of Neurology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Quan
authors.affiliation: a Department of Neurology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Chen
authors.affiliation: a Department of Neurology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Xuezhi
authors.initials: X
authors.lastname: Yang
authors.affiliation: a Department of Neurology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: a Department of Neurology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: a Department of Neurology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Weng
authors.affiliation: b Department of Emergency Medicine , the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Youyu
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Department of Neurology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000359:Aftercare; D000368:Aged; D050197:Atherosclerosis / Q000150:complications*; D002545:Brain Ischemia / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods*; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D020521:Stroke / Q000097:blood* / Q000209:etiology / Q000628:therapy
keywords: Ischemic stroke; large artery atherosclerosis (LAA); platelet; prognosis