title: SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis.
abstract: The HDL receptor scavenger receptor class B type I (SR-BI) plays crucial roles in cholesterol homeostasis, lipoprotein metabolism, and atherosclerosis. Hepatic SR-BI mediates reverse cholesterol transport (RCT) by the uptake of HDL cholesterol for routing to the bile. Through the selective uptake of HDL lipids, hepatic SR-BI modulates HDL composition and preserves HDL's atheroprotective functions of mediating cholesterol efflux and minimizing inflammation and oxidation. Macrophage and endothelial cell SR-BI inhibits the development of atherosclerosis by mediating cholesterol trafficking to minimize atherosclerotic lesion foam cell formation. SR-BI signaling also helps limit inflammation and cell death and mediates efferocytosis of apoptotic cells in atherosclerotic lesions thereby preventing vulnerable plaque formation. SR-BI is emerging as a multifunctional therapeutic target to reduce atherosclerosis development.
authors.affiliation: Atherosclerosis Research Unit, Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-6300, USA; Atherosclerosis Research Unit, Cardiovascular Medicine, Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6300, USA. Electronic address: macrae.linton@vanderbilt.edu.
authors.forename: MacRae F
authors.initials: MF
authors.lastname: Linton
authors.affiliation: Atherosclerosis Research Unit, Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-6300, USA.
authors.forename: Huan
authors.initials: H
authors.lastname: Tao
authors.affiliation: Perelman School of Medicine, University of Pennsylvania, Jordan Medical Education Center, 6th Floor, 3400 Civic Center Blvd, Philadelphia, PA 19104-6055, USA.
authors.forename: Edward F
authors.initials: EF
authors.lastname: Linton
authors.affiliation: Atherosclerosis Research Unit, Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-6300, USA. Electronic address: patricia.g.yancey@vanderbilt.edu.
authors.forename: Patricia G
authors.initials: PG
authors.lastname: Yancey
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism*; D001692:Biological Transport; D002784:Cholesterol / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000378:metabolism
chemical_list: D002784:Cholesterol