title: Myocardial proteases and cardiac remodeling.
abstract: Cardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need to further investigate the signaling pathways that mediate CH in order to identify novel therapeutic targets. One of the hallmarks of CH is the remodeling of the extracellular matrix (ECM). Multiple studies have shown an important role of cysteine proteases and matrix metalloproteinases (MMPs) in the remodeled heart. This review focuses on the role of cysteine cathepins and MMPs in cardiac remodeling.
authors.affiliation: College of Pharmacy, Qatar University, Doha, Qatar.
authors.forename: Sadaf
authors.initials: S
authors.lastname: Riaz
authors.affiliation: Faculty of Medicine, Department of Anatomy, Cell Biology and Physiology, American University of Beirut, Beirut, Lebanon.
authors.forename: Asad
authors.initials: A
authors.lastname: Zeidan
authors.affiliation: College of Pharmacy, Qatar University, Doha, Qatar.
authors.forename: Fatima
authors.identifier: http://orcid.org/0000-0001-6188-1145
authors.initials: F
authors.lastname: Mraiche
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism*; D020257:Ventricular Remodeling
chemical_list: D010447:Peptide Hydrolases; D020782:Matrix Metalloproteinases
keywords: cardiac remodeling; cathepsins; extracellular matrix; heart failure; matrix metalloproteinases