title: Impact of Recruitment Methods in Subjective Cognitive Decline.
abstract: Recruitment methods can determine sample characteristics in mild cognitive impairment and Alzheimer's disease dementia, but little is known about its influence in subjective cognitive decline (SCD).
  
  
  
  To determine the influence of two types of recruitment methods in the characteristics of individuals with SCD.
  
  
  
  We select and compare clinical and neuropsychological features, and frequency of APOE ɛ4 allele of 326 subjects with SCD from two cohorts: Open House Initiative (OHI) versus Memory Unit (MU). A logistic regression analysis (LRA), using gender and years of education as covariates, was used to examine the neuropsychological variables.
  
  
  
  The OHI sample were mostly women (75.9% versus 64.5%, p < 0.05), with higher educational level (12.15 [3.71] versus 10.70 [3.80] years, p = 0.001), and more family history of dementia (138 [62.7%] versus 44 [41.5%], p < 0.001) than the MU sample. Also, the OHI sample showed better overall neuropsychological performance than the MU sample, and after a LRA, this trend continued in automatic response inhibition capacity, abstract reasoning, and recognition memory. We did not find differences in age, depression history, and/or APOE ɛ4 allele frequency.
  
  
  
  SCD subjects showed different demographic and neuropsychological characteristics depending on the recruitment method, which should be taken into account in the design of research studies with this target population.
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Carla
authors.initials: C
authors.lastname: Abdelnour
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Octavio
authors.initials: O
authors.lastname: Rodríguez-Gómez
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Alegret
authors.affiliation: Department of Psychiatry, Hospital Universitari Vall d'Hebron, CIBERSAM, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Sergi
authors.initials: S
authors.lastname: Valero
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Moreno-Grau
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Ángela
authors.initials: Á
authors.lastname: Sanabria
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Hernández
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Maitee
authors.initials: M
authors.lastname: Rosende-Roca
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Liliana
authors.initials: L
authors.lastname: Vargas
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Mauleón
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Domingo
authors.initials: D
authors.lastname: Sánchez
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Espinosa
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Ortega
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Alba
authors.initials: A
authors.lastname: Pérez-Cordón
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Diego
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Gailhajanet
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Guitart
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Óscar
authors.initials: Ó
authors.lastname: Sotolongo-Grau
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Agustín
authors.initials: A
authors.lastname: Ruiz
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Lluís
authors.initials: L
authors.lastname: Tárraga
authors.affiliation: Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Mercè
authors.initials: M
authors.lastname: Boada
mesh_terms: D053327:Apolipoprotein E4 / Q000235:genetics; D060825:Cognitive Dysfunction / Q000235:genetics / Q000523:psychology*; D059026:Diagnostic Self Evaluation; D004522:Educational Status; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D018579:Patient Selection; D012737:Sex Factors
chemical_list: D053327:Apolipoprotein E4
keywords: Alzheimer’s disease; patient recruitment; research subject recruitment; sampling studies; subjective cognitive decline