title: A multicentre validation of the 1-min sit-to-stand test in patients with COPD.
abstract: Our aim was to comprehensively validate the 1-min sit-to-stand (STS) test in chronic obstructive pulmonary disease (COPD) patients and explore the physiological response to the test.We used data from two longitudinal studies of COPD patients who completed inpatient pulmonary rehabilitation programmes. We collected 1-min STS test, 6-min walk test (6MWT), health-related quality of life, dyspnoea and exercise cardiorespiratory data at admission and discharge. We assessed the learning effect, test-retest reliability, construct validity, responsiveness and minimal important difference of the 1-min STS test.In both studies (n=52 and n=203) the 1-min STS test was strongly correlated with the 6MWT at admission (r=0.59 and 0.64, respectively) and discharge (r=0.67 and 0.68, respectively). Intraclass correlation coefficients (95% CI) between 1-min STS tests were 0.93 (0.83-0.97) for learning effect and 0.99 (0.97-1.00) for reliability. Standardised response means (95% CI) were 0.87 (0.58-1.16) and 0.91 (0.78-1.07). The estimated minimal important difference was three repetitions. End-exercise oxygen consumption, carbon dioxide output, ventilation, breathing frequency and heart rate were similar in the 1-min STS test and 6MWT.The 1-min STS test is a reliable, valid and responsive test for measuring functional exercise capacity in COPD patients and elicited a physiological response comparable to that of the 6MWT.
authors.affiliation: Epidemiology, Biostatistics and Prevention Institute, Dept of Epidemiology, University of Zurich, Zurich, Switzerland sarah.crook@uzh.ch.
authors.forename: Sarah
authors.initials: S
authors.lastname: Crook
authors.affiliation: Pulmonary Rehabilitation, Klinik Barmelweid, Barmelweid, Switzerland.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Büsching
authors.affiliation: Centre for Rehabilitation, Pulmonology and Orthopaedics, Klinik Bad Reichenhall, Bad Reichenhall, Germany.
authors.forename: Konrad
authors.initials: K
authors.lastname: Schultz
authors.affiliation: Centre for Rehabilitation, Pulmonology and Orthopaedics, Klinik Bad Reichenhall, Bad Reichenhall, Germany.
authors.forename: Nicola
authors.initials: N
authors.lastname: Lehbert
authors.affiliation: Centre for Rehabilitation, Pulmonology and Orthopaedics, Klinik Bad Reichenhall, Bad Reichenhall, Germany.
authors.forename: Danijel
authors.initials: D
authors.lastname: Jelusic
authors.affiliation: Pulmonology, Zürcher RehaZentrum Wald, Wald, Switzerland.
authors.forename: Stephan
authors.initials: S
authors.lastname: Keusch
authors.affiliation: Centre for Rehabilitation, Pulmonology and Orthopaedics, Klinik Bad Reichenhall, Bad Reichenhall, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Wittmann
authors.affiliation: Dept of Medical Psychology, Medical Sociology and Rehabilitation Sciences, University of Würzburg, Würzburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Schuler
authors.affiliation: Epidemiology, Biostatistics and Prevention Institute, Dept of Epidemiology, University of Zurich, Zurich, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Radtke
authors.affiliation: Pulmonary Rehabilitation, Klinik Barmelweid, Barmelweid, Switzerland.
authors.forename: Martin
authors.initials: M
authors.lastname: Frey
authors.affiliation: Pulmonology, Zürcher RehaZentrum Wald, Wald, Switzerland.
authors.forename: Alexander
authors.initials: A
authors.lastname: Turk
authors.affiliation: Epidemiology, Biostatistics and Prevention Institute, Dept of Epidemiology, University of Zurich, Zurich, Switzerland.
authors.forename: Milo A
authors.initials: MA
authors.lastname: Puhan
authors.affiliation: Epidemiology, Biostatistics and Prevention Institute, Dept of Epidemiology, University of Zurich, Zurich, Switzerland.
authors.forename: Anja
authors.initials: A
authors.lastname: Frei
mesh_terms: D000368:Aged; D004417:Dyspnea / Q000503:physiopathology*; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D006339:Heart Rate; D006801:Humans; D016014:Linear Models; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology* / Q000534:rehabilitation*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D012129:Respiratory Function Tests; D013557:Switzerland