title: Inhibition of triggering receptor expressed on myeloid cells-1 ameliorates experimental autoimmune neuritis.
abstract: Experimental autoimmune neuritis (EAN) is a cluster of differentiation 4+ T helper 1 cell-mediated inflammatory demyelinating disease of the peripheral nervous system and serves as a useful animal model for Guillain‑Barré syndrome. Triggering receptor expressed on myeloid cells‑1 (TREM‑1) is an important receptor involved in sepsis and the innate inflammatory response. Linear plasmid 17 (LP 17) peptide is a competitive antagonist of TREM‑1. To investigate the role of TREM‑1 in EAN, 64 male Lewis rats were randomly divided into four groups: Normal saline, complete Freund's adjuvant, EAN and LP 17. The present study assessed the mRNA expression levels of TREM‑1, tumor necrosis factor‑α and interleukin‑1β in sciatic nerves and peripheral blood mononuclear cells. The results demonstrated that inhibiting TREM-1 by administering LP 17 ameliorated symptoms and reduced inflammation in EAN rats. The present study concluded that TREM‑1 may be involved in the pathogenesis of EAN, and that inhibition of TREM-1 may ameliorate EAN.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central‑South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Jingzhou Central Hospital, Jingzhou, Hubei 434020, P.R. China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China.
authors.forename: Yuzhong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, Stanford Medical Center, Stanford, CA 94305, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Cipriano
authors.affiliation: Department of Neurology, Xiangya Hospital, Central‑South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xiao
authors.affiliation: Department of Neurology, Xiangya Hospital, Central‑South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Zhou
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D053583:Interleukin-1beta / Q000235:genetics / Q000378:metabolism; D008297:Male; D009444:Neuritis, Autoimmune, Experimental / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011917:Rats, Inbred Lew; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012584:Sciatic Nerve / Q000473:pathology; D013194:Staining and Labeling; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D053583:Interleukin-1beta; D012333:RNA, Messenger; D011971:Receptors, Immunologic; C547511:TREM1 protein, rat; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D014409:Tumor Necrosis Factor-alpha