title: Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension.
abstract: One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations ofTHcould alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Here, we discuss the role of TH as a regulator of sympathetic activity and review several studies that investigated the relationship between genetic variations ofTHand hypertension.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Yu Ho
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Yang Gyun
authors.initials: YG
authors.lastname: Kim
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Moon
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Jin Sug
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Kyung-Hwan
authors.initials: KH
authors.lastname: Jeong
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Tae Won
authors.initials: TW
authors.lastname: Lee
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Chun-Gyoo
authors.initials: CG
authors.lastname: Ihm
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Lee
keywords: Hypertension; Single nucleotide polymorphism; Tyrosine hydroxylase