title: The ratio of monocyte frequency to HDL cholesterol level as a predictor of asymptomatic organ damage in patients with primary hypertension.
abstract: This study aimed to examine the relationship between the ratio of monocyte frequency to high-density lipoprotein (HDL) cholesterol level (the monocyte/HDL ratio (MHR)) and asymptomatic organ damage (AOD) in primary hypertension (PHT). A total of 366 participants were enrolled in the study, including 275 cases currently being followed up after a diagnosis of PHT in our clinic and 91 healthy volunteers. The MHR was higher in patients with PHT than in individuals in the control group. In the PHT group, the MHR was higher in patients with AOD (AOD+) than in patients without AOD (AOD-). In the correlation analyses performed in the PHT group, there were positive correlations between the MHR and the following AOD indicators: carotid intima media thickness, left ventricular mass index, urinary protein levels and urinary albumin levels. In a multivariate linear regression analysis, the MHR was found to be an independent risk factor associated with these indicators of AOD. In conclusion, our study shows that MHR is associated with AOD in patients with PHT.
authors.affiliation: Department of Internal Medicine, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Aydin
authors.affiliation: Department of Internal Medicine, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ates
authors.affiliation: Department of Internal Medicine, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Fettah Arikan
authors.affiliation: Department of Internal Medicine, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Nisbet
authors.initials: N
authors.lastname: Yilmaz
authors.affiliation: Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Dede
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000150:complications; D001794:Blood Pressure; D059168:Carotid Intima-Media Thickness; D008076:Cholesterol, HDL / Q000097:blood*; D004452:Echocardiography; D000075222:Essential Hypertension / Q000097:blood* / Q000473:pathology*; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes; D011237:Predictive Value of Tests; D011507:Proteinuria / Q000150:complications; D012307:Risk Factors
chemical_list: D008076:Cholesterol, HDL