title: Successful pregnancy after natalizumab-associated progressive multifocal leukoencephalopathy in a patient with multiple sclerosis.
abstract: We report the case of a post-progressive multifocal leukoencephalopathy (PML), multiple sclerosis (MS) patient with an uncomplicated pregnancy and delivery. A 28-year-old woman on natalizumab (total of 49 infusions) was diagnosed with PML due to typical magnetic resonance imaging (MRI) and clinical presentation. John Cunningham virus (JCV) was detected in the cerebrospinal fluid (CSF) during the immune reconstitution inflammatory syndrome (IRIS). Nine months after PML onset, JCV negativity in the CSF was observed. MS was stabilised with dimethyl fumarate (DMF), and 18 months later, a desired pregnancy was reported, resulting in the birth of a healthy boy. Our report gives new hope regarding family planning for post-PML patients.
authors.affiliation: Department of Neurology, St. Josef Hospital, Ruhr-University of Bochum, Bochum, Germany.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Pitarokoili
authors.affiliation: Department of Neurology, St. Josef Hospital, Ruhr-University of Bochum, Bochum, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Hellwig
authors.affiliation: Institute of Diagnostic and Interventional Radiology, St. Josef Hospital, Ruhr-University of Bochum, Bochum, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Lukas
authors.affiliation: Department of Neurology, St. Josef Hospital, Ruhr-University of Bochum, Bochum, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Gold
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007577:JC Virus; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced* / Q000175:diagnosis; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*; D000069442:Natalizumab / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D000069442:Natalizumab
keywords: Multiple sclerosis; natalizumab