title: Progress in Nanotheranostics Based on Mesoporous Silica Nanomaterial Platforms.
abstract: Theranostics based on nanoparticles (NPs) is a promising paradigm in nanomedicine. Mesoporous silica nanoparticle (MSN)-based systems offer unique characteristics to enable multimodal imaging or simultaneous diagnosis and therapy. They include large surface area and volume, tunable pore size, functionalizable surface, and acceptable biological safety. Hybridization with other NPs and chemical modification can further potentiate the multifunctionality of MSN-based systems toward translation. Here, we update the recent progress on MSN-based systems for theranostic purposes. We discuss various synthetic approaches used to construct the theranostic platforms either via intrinsic chemistry or extrinsic combination. These include defect generation in the silica structure, encapsulation of diagnostic NPs within silica, their assembly on the silica surface, and direct conjugation of dye chemicals. Collectively, in vitro and in vivo results demonstrate that multimodal imaging capacities can be integrated with the therapeutic functions of these MSN systems for therapy. With further improvement in bioimaging sensitivity and targeting specificity, the multifunctional MSN-based theranostic systems will find many clinical applications in the near future.
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), Dankook University , Cheonan 330-714, South Korea.|Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University , Cheonan 330-714, South Korea.
authors.forename: Rajendra K
authors.initials: RK
authors.lastname: Singh
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), Dankook University , Cheonan 330-714, South Korea.|Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University , Cheonan 330-714, South Korea.
authors.forename: Kapil D
authors.initials: KD
authors.lastname: Patel
authors.affiliation: Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University , Cheonan 330-714, South Korea.|Department of Biomedical Engineering, Columbia University , New York, New York 10027, United States.
authors.forename: Kam W
authors.initials: KW
authors.lastname: Leong
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), Dankook University , Cheonan 330-714, South Korea.|Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University , Cheonan 330-714, South Korea.|Department of Biomaterials Science, College of Dentistry, Dankook University , Cheonan 330-714, South Korea.
authors.forename: Hae-Won
authors.identifier: http://orcid.org/0000-0001-6400-6100
authors.initials: HW
authors.lastname: Kim
mesh_terms: D053758:Nanoparticles; D049329:Nanostructures; D016062:Porosity; D012822:Silicon Dioxide; D000068936:Theranostic Nanomedicine
chemical_list: D012822:Silicon Dioxide
keywords: extrinsic combination; intrinsic defect; mesoporous silica nanoparticles; multifunctional; theranostics