title: Synthesis of a new magnetic-MIP for the selective detection of 1-chloro-2,4-dinitrobenzene, a highly allergenic compound.
abstract: Molecularly imprinted polymers (MIPs) in combination with magnetic nanoparticles, in a core@shell format, were studied for selective detection of 1-chloro-2,4-dinitrobenzene (CDNB), a powerful allergenic substance. Magnetic nanoparticles were prepared by the co-precipitation method and mixed with oleic acid (OA). This material was then encapsulated in three types of hydrophobic polymeric matrix, poly-(MA-co-EDGMA), poly-(AA-co-EDGMA), and poly-(1-VN-co-EDGMA), by the mini-emulsion method. These matrices were used due to their ability to interact specifically with the functional groups of the analyte. Finally, the MIP-CDNB was obtained on the magnetic-hydrophobic surfaces using precipitation polymerization in the presence of the analyte. XRD diffraction patterns suggested the presence of magnetite in the composite and SEM analysis revealed a nanoparticle size between 10 and 18nm. Under the optimized adsorption conditions, the magnetic-MIP material showed a higher adsorption capacity (5.1mgg-1) than its non-magnetic counterpart (4.2mgg-1). In tests of the selectivity of the magnetic-MIP towards CDNB, α-values of 2.5 and 10.4, respectively, were obtained for dichlorophenol and o-nitrophenol, two structurally similar compounds, and no adsorption was observed for any other non-analogous analyte. The magnetic-MIP and magnetic-NIP were applied using water enriched with 0.5mgL-1of CDNB, achieving recovery values of 83.8(±0.8)% and 66(±1)%, respectively, revealing the suitability of the material for detection of CDNB.
authors.affiliation: Department of Analytical Chemistry, Institute of Chemistry, State University of São Paulo (UNESP), 14801-970 Araraquara, SP, Brazil; Laboratory of Physical Chemistry Research, Faculty of Science, National University of Engineering, Av. Tupac Amaru 210, Rimac, Lima, Peru.
authors.forename: Rosario Josefina
authors.initials: RJ
authors.lastname: Uzuriaga-Sánchez
authors.affiliation: Department of Analytical Chemistry, Institute of Chemistry, State University of São Paulo (UNESP), 14801-970 Araraquara, SP, Brazil.
authors.forename: Ademar
authors.initials: A
authors.lastname: Wong
authors.affiliation: Department of Analytical Chemistry, Institute of Chemistry, State University of São Paulo (UNESP), 14801-970 Araraquara, SP, Brazil.
authors.forename: Sabir
authors.initials: S
authors.lastname: Khan
authors.affiliation: Sensors and Biosensors Group, Department of Chemistry, Autonomous University of Barcelona (UAB), 08193, Bellaterra, Barcelona, Spain.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Pividori
authors.affiliation: Laboratory of Physical Chemistry Research, Faculty of Science, National University of Engineering, Av. Tupac Amaru 210, Rimac, Lima, Peru. Electronic address: gpicasso@uni.edu.pe.
authors.forename: Gino
authors.initials: G
authors.lastname: Picasso
authors.affiliation: Department of Analytical Chemistry, Institute of Chemistry, State University of São Paulo (UNESP), 14801-970 Araraquara, SP, Brazil. Electronic address: mpilar@iq.unesp.br.
authors.forename: Maria D P T
authors.initials: MDPT
authors.lastname: Sotomayor
mesh_terms: D000485:Allergens / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004137:Dinitrochlorobenzene / Q000032:analysis*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D054802:Molecular Imprinting; D019301:Oleic Acid / Q000737:chemistry; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity; D015203:Reproducibility of Results; D014961:X-Ray Diffraction
chemical_list: D000485:Allergens; D004137:Dinitrochlorobenzene; D058185:Magnetite Nanoparticles; D011108:Polymers; D019301:Oleic Acid
keywords: 1-Chloro-2,4-dinitrobenzene; Allergenic substances; Biomimetic polymers; Environmental control; Magnetic-MIP; Plastic antibodies