title: BCG and Kawasaki disease in Mexico and Japan.
abstract: Dr. Tomisaku Kawasaki was the first to describe BCG reactivation in Kawasaki Disease (KD), and this sign is present in about 30-50% of KDpatients. It is a very specific early sign of the disease and although it has been recognized for decades, its pathophysiology continues to be an enigma. Recently, Yamada et al. reported a severe BCG reaction with tuberculid in 2 Japanese KDpatients. We present 2 cases with KDand severe BCG reaction, one from Japan and the other from Mexico and review the policies of administration of BCG in both countries. The BCG vaccine has a worldwide coverage of 88%. Differences in BCG strains and methods of administration may influence BCG reactions in KD. The BCG reaction in the inoculation site may represent the most useful sign in KD.
authors.affiliation: a Department of Allergy and Clinical Immunology , Hospital Infantil de Especialidades de Chihuahua , Chihuahua , Mexico.
authors.forename: Luisa Berenise
authors.initials: LB
authors.lastname: Gamez-Gonzalez
authors.affiliation: b Department of Pediatrics , Yachiyo Medical Center, Tokyo Women's Medical University , Yachiyo , Chiba , Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Hamada
authors.affiliation: c Department of Allergy and Immunology , Hospital del Niño y Adolescente Morelense , Cuernavaca Morelos , Mexico.
authors.forename: Beatriz Adriana
authors.initials: BA
authors.lastname: Llamas-Guillen
authors.affiliation: c Department of Allergy and Immunology , Hospital del Niño y Adolescente Morelense , Cuernavaca Morelos , Mexico.
authors.forename: Miguel
authors.initials: M
authors.lastname: Ruiz-Fernandez
authors.affiliation: d Department of Clinical Immunology , Instituto Nacional de Pediatría, Insurgentes Cuicuilco Coyoacan , Mexico City , Mexico.
authors.forename: Marco
authors.initials: M
authors.lastname: Yamazaki-Nakashimada
mesh_terms: D001500:BCG Vaccine / Q000009:adverse effects* / Q000276:immunology*; D003429:Cross Reactions; D005260:Female; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009080:Mucocutaneous Lymph Node Syndrome / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology*; D014382:Tuberculosis, Cutaneous / Q000209:etiology / Q000276:immunology*; D014611:Vaccination
chemical_list: D001500:BCG Vaccine
keywords: BCG; Kawasaki disease; Tuberculid; tokyo172