title: Real-time light dosimetry for intra-cavity photodynamic therapy: Application for pleural mesothelioma treatment.
abstract: Complete and homogeneous illumination of the target is necessary for the success of a photodynamic therapy (PDT) procedure. In most applications, light dosimetry is done using detectors placed at strategic locations of the target. In this study we propose a novel approach based on the combination of light distribution modeling with spatial localization of the light applicator for real time estimation and display of the applied dose on medical images. The feasibility approach is demonstrated for intrapleural PDT of malignant pleural mesothelioma.
authors.affiliation: INSERM, U1189, 1, Avenue Oscar Lambret, 59037, Lille Cedex, France; Lille University Hospital, 59037 Lille Cedex, France. Electronic address: nacim.betrouni@inserm.fr.
authors.forename: Nacim
authors.initials: N
authors.lastname: Betrouni
authors.affiliation: INSERM, U1189, 1, Avenue Oscar Lambret, 59037, Lille Cedex, France; Lille University Hospital, 59037 Lille Cedex, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Munck
authors.affiliation: INSERM, U1189, 1, Avenue Oscar Lambret, 59037, Lille Cedex, France.
authors.forename: Wael
authors.initials: W
authors.lastname: Bensoltana
authors.affiliation: INSERM, U1189, 1, Avenue Oscar Lambret, 59037, Lille Cedex, France.
authors.forename: Grégory
authors.initials: G
authors.lastname: Baert
authors.affiliation: INSERM, U1189, 1, Avenue Oscar Lambret, 59037, Lille Cedex, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Dewalle-Vignion
authors.affiliation: Lille University Hospital, 59037 Lille Cedex, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Scherpereel
authors.affiliation: INSERM, U1189, 1, Avenue Oscar Lambret, 59037, Lille Cedex, France; Lille University Hospital, 59037 Lille Cedex, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Mordon
mesh_terms: D003199:Computer Systems; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005240:Feasibility Studies; D006801:Humans; D008027:Light; D008654:Mesothelioma / Q000188:drug therapy* / Q000473:pathology; D019047:Phantoms, Imaging; D010778:Photochemotherapy / Q000379:methods*; D010783:Photometry / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D010997:Pleural Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents
keywords: Dosimetry; Imaging; Intra-cavity application; Light distribution modeling; Photodynamic therapy; Real time tracking