title: The effect of nonsurgical periodontal treatment on serum and gingival crevicular fluid markers in patients with atherosclerosis.
abstract: The aim of this study is to compare patients with atherosclerosis and chronic periodontitis and patients who are systemically healthy and chronic periodontitis using alteration of adrenomedullin (ADM), chemokine (C-C motif) ligand 28 (CCL-28), white blood cell levels, platelet levels, high-density lipoprotein, low-density lipoprotein, high-sensitivity C-reactive protein, creatinine, and fibrinogen.
  
  
  
  Totally, 40 patients were involved in study; a test group of 20 patients with atherosclerosis-chronic periodontitis and a control group of 20 patients who were nonatherosclerosis-chronic periodontitis. Nonsurgical periodontal treatment was offered to all patients, in whom systemic markers of atherosclerosis were measured in serum; ADM and CCL-28 biomarkers were measured in gingival crevicular fluid.
  
  
  
  Systemic markers of atherosclerosis, ADM, and CCL-28 levels have changed significantly in the test group compared to the control group after nonsurgical periodontal treatment.
  
  
  
  Treatment of local inflammation and reduction of systemic inflammatory markers are believed to lower the diagnostic criteria for atherosclerosis as well. It is possible to conclude that nonsurgical periodontal treatment of chronic periodontitis, which is a risk factor for atherosclerosis, has a positive effect on the atherosclerosis prognosis.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey.
authors.forename: A S
authors.initials: AS
authors.lastname: Ertugrul
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Yuzuncu Yil University, Van, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Bozoglan
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Taspınar
mesh_terms: D053607:Adrenomedullin / Q000378:metabolism*; D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D019742:Chemokines, CC / Q000378:metabolism*; D055113:Chronic Periodontitis / Q000150:complications / Q000378:metabolism* / Q000628:therapy*; D003404:Creatinine / Q000097:blood; D005340:Fibrinogen / Q000378:metabolism; D005883:Gingival Crevicular Fluid / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D008075:Lipoproteins, HDL / Q000097:blood; D008875:Middle Aged; D010512:Periodontal Index
chemical_list: D015415:Biomarkers; C414047:CCL28 protein, human; D019742:Chemokines, CC; D008075:Lipoproteins, HDL; D053607:Adrenomedullin; D005340:Fibrinogen; D002097:C-Reactive Protein; D003404:Creatinine