title: Endometriosis-associated changes in serum levels of interferons and chemokines.
abstract: The aim of the study was to evaluate the serum concentration of main chemokines and interferons in patients with diagnosed endometriosis.
  
  
  
  A total of 160 women were divided in two study groups (group 1 - endometriosis; group 2 - healthy women). Serum levels of IFN-α, IFN-γ, MCP-1, MIP-1α, MIP-1β, RANTES, eotaxin, IL-8, MIG, IP-10, and IL-17A were measured with Human Multiplex Cytokine Panels. Results. Serum levels of IFN-γ, MCP-1, and IL-8 were significantly higher (mean 14.03, 57.24, and 534.24, respectively, compared to 0.58, 20.51, and 259.82, respectively), and serum levels of IP-10 and eotaxin were significantly lower in women with endometriosis compared to the controls (mean 1.15 and 1.01, respectively, compared to 3.90 and 3.22, respectively). Conclusions. According to our results women with endometriosis have elevated levels IFN-γ, MCP-1, and IL-8, and lower serum levels of IP-10 and eotaxin, indicating unbalanced immune activity in endometriosis.
authors.affiliation: nd Obstetrics and Gynecology Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Andrei Mihai
authors.initials: AM
authors.lastname: Măluțan
authors.affiliation: Medical Informatics and Biostatistics Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Tudor
authors.initials: T
authors.lastname: Drugan
authors.affiliation: nd Obstetrics and Gynecology Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Răzvan
authors.initials: R
authors.lastname: Ciortea
authors.affiliation: nd Obstetrics and Gynecology Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Carmen
authors.initials: C
authors.lastname: Bucuri
authors.affiliation: nd Obstetrics and Gynecology Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Maria Patricia
authors.initials: MP
authors.lastname: Rada
authors.affiliation: nd Obstetrics and Gynecology Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Dan
authors.initials: D
authors.lastname: Mihu
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D004715:Endometriosis / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007372:Interferons / Q000097:blood*; D055815:Young Adult
chemical_list: D018925:Chemokines; D007372:Interferons