title: The roles of drug therapy given via the endotracheal tube to neonates.
abstract: Many drugs are given to intubated neonates by the inhalation route. The optimum aerosol delivery system, however, has not been identified and there are many challenges in delivering drugs effectively to the lower airways of intubated neonates. The effectiveness of surfactant in prematurely born infants and nitric oxide has been robustly investigated. Other drugs are being used on very limited evidence.
authors.affiliation: Division of Asthma, Allergy and Lung Biology, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.|NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Greenough
authors.affiliation: Division of Asthma, Allergy and Lung Biology, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.
authors.forename: Niovi
authors.initials: N
authors.lastname: Papalexopoulou
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D016503:Drug Delivery Systems / Q000379:methods*; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007224:Infant Care / Q000379:methods*; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D010102:Oxygen Inhalation Therapy / Q000379:methods; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D000336:Aerosols; D005938:Glucocorticoids; D011663:Pulmonary Surfactants; D014665:Vasodilator Agents
keywords: Bronchodilators; Neonate; Pulmonary vasodilators; Surfactant