title: Short-term Changes in Gal 3 Circulating Levels After Acute Myocardial Infarction.
abstract: Galectin 3 (Gal 3) is a β-galactoside-binding lectin known to play a part in inflammation, adverse remodeling and fibrosis. Gal 3 seems to be linked to atherogenesis and Coronary Artery Disease (CAD), but less is known about the relationship between Gal 3 and acute myocardial infarction (AMI). The aim of the present study is to assess circulating levels of Gal 3 after AMI and to evaluate short-term changes of the biomarker within 5 days from the acute event.
  
  
  
  Two hundred fifteen confirmed AMI patients (125 STEMI, M/F = 2.8; mean age: 65.4 ± 13.8 years) were enrolled in the present study; two blood samples were collected from each patient: first, within 1 h from admission to the Emergency Area (T1) and then upon discharge (T2).
  
  
  
  Kinetics of Gal 3 during AMI show that the marker boosts during the acute event (T1) and then decreases from baseline, being significantly lower at T2 (18 [14.2-25] vs. 16.8 [12.7-23.4]; p = 0.006). Gal 3 levels were correlated to hsTnI and eGFR on admission (r = 0.2; p <0.001 and r = -0.25; p <0.001, respectively). Linear regression analysis confirms an association between Gal 3 and ejection fraction (r2= 0.037; p = 0.005).
  
  
  
  Gal 3 is reasonably supposed to be a part of those mechanisms leading to formation, destabilization and rupture of plaque; however, the usefulness of Gal 3 as a biomarker in CAD/AMI is far from being elucidated.
authors.affiliation: Dipartimento di Biopatologia e Biotecnologie Mediche, Sezione di Biochimica Clinica e Medicina Molecolare Clinica, Università degli Studi di Palermo, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Bivona
authors.affiliation: Dipartimento di Biopatologia e Biotecnologie Mediche, Sezione di Biochimica Clinica e Medicina Molecolare Clinica, Università degli Studi di Palermo, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Bellia
authors.affiliation: Dipartimento di Biopatologia e Biotecnologie Mediche, Sezione di Biochimica Clinica e Medicina Molecolare Clinica, Università degli Studi di Palermo, Italy.
authors.forename: Bruna
authors.initials: B
authors.lastname: Lo Sasso
authors.affiliation: Dipartimento di Biopatologia e Biotecnologie Mediche, Sezione di Biochimica Clinica e Medicina Molecolare Clinica, Università degli Studi di Palermo, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Agnello
authors.affiliation: Dipartimento di Biopatologia e Biotecnologie Mediche, Sezione di Biochimica Clinica e Medicina Molecolare Clinica, Università degli Studi di Palermo, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Scazzone
authors.affiliation: Cattedra di Cardiologia, AOUP Policlinico P. Giaccone, Palermo, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Novo
authors.affiliation: Dipartimento di Biopatologia e Biotecnologie Mediche, Sezione di Biochimica Clinica e Medicina Molecolare Clinica, Università degli Studi di Palermo, Italy; UOC Medicina di Laboratorio-CoreLab, AOUP P. Giaccone, Palermo, Italy. Electronic address: marcello.ciaccio@unipa.it.
authors.forename: Marcello
authors.initials: M
authors.lastname: Ciaccio
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology; D005260:Female; D037502:Galectin 3 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D015415:Biomarkers; D037502:Galectin 3
keywords: AMI; CAD; Galectin 3; Inflammation; Plaque