title: [Decontamination of organophosphorus compounds: Towards new alternatives].
abstract: Organophosphorus coumpounds (OP) are toxic chemicals mainly used for agricultural purpose such as insecticides and were also developed and used as warfare nerve agents. OP are inhibitors of acetylcholinesterase, a key enzyme involved in the regulation of the central nervous system. Chemical, physical and biological approaches have been considered to decontaminate OP. This review summarizes the current and emerging strategies that are investigated to tackle this issue with a special emphasis on enzymatic remediation methods. During the last decade, many studies have been dedicated to the development of biocatalysts for OP removal. Among these, recent reports have pointed out the promising enzyme SsoPox isolated from the archaea Sulfolobus solfataricus. Considering both its intrinsic stability and activity, this hyperthermostable enzyme is highly appealing for the decontamination of OP.
authors.affiliation: Inserm, CNRS, IRD, URMITE, Aix Marseille université, Marseille, France.
authors.forename: L
authors.initials: L
authors.lastname: Poirier
authors.affiliation: Inserm, CNRS, IRD, URMITE, Aix Marseille université, Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Jacquet
authors.affiliation: Department of Biochemistry, Molecular Biology and Biophysics & Biotechnology Institute, University of Minnesota, St. Paul, MN 55108, États-Unis.
authors.forename: M
authors.initials: M
authors.lastname: Elias
authors.affiliation: Gene&GreenTK, faculté de médecine, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France. Electronic address: david.daude@gene-greentk.com.
authors.forename: D
authors.initials: D
authors.lastname: Daudé
authors.affiliation: Inserm, CNRS, IRD, URMITE, Aix Marseille université, Marseille, France; Gene&GreenTK, faculté de médecine, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France. Electronic address: eric.chabriere@univ-amu.fr.
authors.forename: E
authors.initials: E
authors.lastname: Chabrière
mesh_terms: D000818:Animals; D002619:Chemical Warfare Agents / Q000032:analysis; D002800:Cholinesterase Inhibitors / Q000032:analysis; D003666:Decontamination / Q000379:methods*; D006801:Humans; D007306:Insecticides / Q000032:analysis; D009943:Organophosphorus Compounds / Q000032:analysis*
chemical_list: D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009943:Organophosphorus Compounds
keywords: Agents chimiques de guerre; Bioremediation; Bioremédiation; Chemical warfare agents; Decontamination; Décontamination; Enzyme; Enzymes; Insecticides; Organophosphorus coumpounds; Organophosphorés; Phosphotriesterase; Phosphotriestérase; SsoPox