title: Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I.
abstract: Lead poisoning is one of the most significant health problem of environmental origin. It is known to cause different damages in the central and peripheral nervous system which could be represented by several neurophysiological and behavioral symptoms. In this study we firstly investigated the effect of lead prenatal exposure in rats to (3g/L), from neonatal to young age, on the motor/sensory performances, excitability of the spinal cord and gaits during development. Then we evaluated neuroprotective effects of curcumin I (Cur I) against lead neurotoxicity, by means of grasping and cliff avoidance tests to reveal the impairment of the sensorimotor functions in neonatal rats exposed prenatally to lead. In addition, extracellular recordings of motor output in spinal cord revealed an hyper-excitability of spinal networks in lead treated rats. The frequency of induced fictive locomotion was also increased in treated rats. At the young age, rats exhibited an impaired locomotor gait. All those abnormalities were attenuated by Cur I treatment at a dose of 16g/kg. Based on our finding, Cur I has shown features of a potent chemical compound able to restore the neuronal and the relative locomotor behaviors disturbances induced by lead intoxication. Therefore, this chemical can be recommended as a new therapeutic trial against lead induced neurotoxicity.
authors.affiliation: Neuroscience, Pharmacology and Environment Team, faculty of Science Semlalia, Cadi Ayyad University, Marrakech, Morocco.
authors.forename: Hind
authors.initials: H
authors.lastname: Benammi
authors.affiliation: Neuroscience, Pharmacology and Environment Team, faculty of Science Semlalia, Cadi Ayyad University, Marrakech, Morocco.
authors.forename: Hasna
authors.initials: H
authors.lastname: Erazi
authors.affiliation: Neuroscience, Pharmacology and Environment Team, faculty of Science Semlalia, Cadi Ayyad University, Marrakech, Morocco.|Department of Biology, faculty of Sciences, Chouaib Doukkali University, EL Jadida, Morocco.
authors.forename: Omar
authors.initials: O
authors.lastname: El Hiba
authors.affiliation: Institut de Neurosciences de la Timone, Unité Mixte de Recherche 7289, CNRS, Université Aix-Marseille, Marseille, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Vinay
authors.affiliation: Institut de Neurosciences de la Timone, Unité Mixte de Recherche 7289, CNRS, Université Aix-Marseille, Marseille, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Bras
authors.affiliation: Institut de Neurosciences de la Timone, Unité Mixte de Recherche 7289, CNRS, Université Aix-Marseille, Marseille, France.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Viemari
authors.affiliation: Neuroscience, Pharmacology and Environment Team, faculty of Science Semlalia, Cadi Ayyad University, Marrakech, Morocco.
authors.forename: Halima
authors.identifier: http://orcid.org/0000-0002-0254-3629
authors.initials: H
authors.lastname: Gamrani
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology*; D055724:Electrophysiological Phenomena / Q000187:drug effects*; D005260:Female; D005684:Gait / Q000187:drug effects; D007855:Lead Poisoning; D008124:Locomotion / Q000187:drug effects; D018811:Maternal Exposure; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011247:Pregnancy; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects; D013997:Time Factors
chemical_list: D018696:Neuroprotective Agents; D003474:Curcumin