title: Myo-inositol administration positively effects ovulation induction and intrauterine insemination in patients with polycystic ovary syndrome: a prospective, controlled, randomized trial.
abstract: Objectıve: The aim of the study is to investigate the effect of myo-inositol (MYO) on pregnancy rates of patients diagnosed with polycystic ovary syndrome (PCOS) who undergone controlled ovulation induction and intrauterine insemination (IUI).
  
  
  METHODS
  A total of 196 infertile patients diagnosed with PCOS and admitted to Dokuz Eylul University Faculty of Medicine were included in the study between March 2013 and May 2016. The patients in group 1 (n = 98) were given 4 g MYO and 400 μg folic acid before and during ovulation induction. The patients undergone controlled ovarian hyperstimulation (COH) with recombinant FSH and IUI. The patients in group 2 (n = 98), were given recombinant FSH directly and 400 μg folic acid. The primary outcome measure of this study was the clinical pregnancy rate.
  
  
  RESULTS
  In group 1, 9 patients conceived spontaneous pregnancy. During COH + IUI treatment three cycles were canceled in group 1 and 8 cycles in group 2. Total rFSH dose and cycle duration were significantly lower and clinical pregnancy rates were higher in group 1. The pregnancy rate for group 1 was %18.6 and for group 2 was %12.2. Conclusıons: This study shows that MYO should be considered in the treatment of infertile PCOS patients. MYO administration increases clinical pregnancy rates, lowers total rFSH dose and the duration of the ovulation induction.
authors.affiliation: a Department of Obstetrics and Gynecology , Konya Aksehir State Hospital , Konya , Turkey and.
authors.forename: Özlen
authors.initials: Ö
authors.lastname: Emekçi Özay
authors.affiliation: a Department of Obstetrics and Gynecology , Konya Aksehir State Hospital , Konya , Turkey and.
authors.forename: Ali Cenk
authors.initials: AC
authors.lastname: Özay
authors.affiliation: b Department of Obstetrics and Gynecology , Dokuz Eylul University, School of Medicine , Izmir , Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Çağlıyan
authors.affiliation: b Department of Obstetrics and Gynecology , Dokuz Eylul University, School of Medicine , Izmir , Turkey.
authors.forename: Recep Emre
authors.initials: RE
authors.lastname: Okyay
authors.affiliation: b Department of Obstetrics and Gynecology , Dokuz Eylul University, School of Medicine , Izmir , Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Gülekli
mesh_terms: D000328:Adult; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D006801:Humans; D007294:Inositol / Q000627:therapeutic use*; D007315:Insemination, Artificial; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005300:Fertility Agents, Female; D007294:Inositol; D005640:Follicle Stimulating Hormone
keywords: Infertility; insulin resistance; insulin sensitizer; ovulation induction; polycystic ovary syndrome