title: Bringing hemodynamic simulations closer to the clinics: a CFD prototype study for intracranial aneurysms.
abstract: Computational Fluid Dynamics enables the investigation of patient-specific hemodynamics for rupture predictions and treatment support of intracranial aneurysms. However, due to numerous simplifications to decrease the computations effort, clinical applicability is limited until now. To overcome this situation a clinical research software prototype was tested that can be easily operated by attending physicians. In order to evaluate the accuracy of this prototype, four patient-specific intracranial aneurysms were investigated using four different spatial resolutions. The results demonstrate that physicians were able to generate hemodynamic predictions within several minutes at low spatial resolution. However, depending on the parameter of interest and the desired accuracy, higher resolutions are required, which will lead to an increase of computational times that still look very attractive towards clinical usability. The study shows that the next step towards an applicable individualized therapy for patients harboring intracranial aneurysms can be done. However, further in vivo validations are required to guarantee realistic predictions in future studies.
authors.forename: Philipp
authors.initials: P
authors.lastname: Berg
authors.forename: Samuel
authors.initials: S
authors.lastname: Vos
authors.forename: Mathias
authors.initials: M
authors.lastname: Becker
authors.forename: Steffen
authors.initials: S
authors.lastname: Serowy
authors.forename: Thomas
authors.initials: T
authors.lastname: Redel
authors.forename: Gabor
authors.initials: G
authors.lastname: Janiga
authors.forename: Martin
authors.initials: M
authors.lastname: Skalej
authors.forename: Oliver
authors.initials: O
authors.lastname: Beuing
mesh_terms: D000328:Adult; D003198:Computer Simulation; D005260:Female; D006439:Hemodynamics; D006801:Humans; D057446:Hydrodynamics; D002532:Intracranial Aneurysm / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results