title: The elevated lipoprotein-associated phospholipase A2 activity is associated with the occurrence and recurrence of acute cerebral infarction.
abstract: There is a strong association between lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and atherosclerosis-related diseases. The aim of this study was to investigate the role of Lp-PLA2 in the ischemic stroke and further offer clinical evidence that measuring Lp-PLA2 helps predict the risk of stroke occurrence and recurrence. A total of 328 hospitalized patients were recruited, including 179 cases of acute cerebral infarction (ACI) and 149 non-ACI controls. The serum level of Lp-PLA2 in ACI was significantly higher than non-ACI. The serum level of Lp-PLA2 in the recurrence of ACI was significantly higher than the nonrecurrence. The serum levels of Lp-PLA2 in large-artery atherosclerosis subtype were the highest among the subtypes of the Trial of Org 10172 in Acute Stroke Treatment and non-ACI controls. The level of Lp-PLA2 in large-artery atherosclerosis and the cardioembolism group was statistically significantly higher than that of the control cases. There was no statistically significant difference between the small-vessel occlusion group and the control cases. The present study confirmed that the elevated Lp-PLA2 level can be a risk factor for ischemic stroke in the Chinese population. The serum level of Lp-PLA2 may be a predictive factor for the recurrence of ACI.
authors.affiliation: aDepartment of Neurology, Xiangyang Central Hospital, the Affiliated Hospital of Hubei University of Arts and Science, Xiangyang bDepartment of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province cDepartment of Neurology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province dDepartment of Neurology, Chongqing General Hospital, Chongqing, Chongqing municipality, People's Republic of China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Wei
authors.forename: Zunyu
authors.initials: Z
authors.lastname: Ke
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Zhiyou
authors.initials: Z
authors.lastname: Cai
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002544:Cerebral Infarction / Q000097:blood* / Q000201:enzymology* / Q000628:therapy; D002681:China; D005260:Female; D006760:Hospitalization; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000097:blood / Q000201:enzymology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D054467:Phospholipases A2 / Q000097:blood*; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D054467:Phospholipases A2