title: [Association of the polymorphic marker Glu23Lys in the KCNJ11 gene with hypertension in Kyrgyz patients].
abstract: OBJECTIVE
  To study the association of the polymorphic marker Glu23Lys in the KCNJ11 with the development of hypertension in Kyrgyz patients.
  
  
  METHODS
  This case-control study enrolled 214 unrelated ethnic Kyrgyzes, in which a study group included 152 hypertensive patients (82 men and 70 women) and a control group consisted of 109 apparently healthy individuals (61 men and 48 women). The examinees' mean age was 55.2±10.1 years. Hypertension was verified when blood pressure (BP) was above 140/90 mm Hg. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to identify the polymorphic marker Glu23Lys in the KCNJ11 gene.
  
  
  RESULTS
  In the hypertension and control groups, the prevalence of 3 genotypes (Glu23Glu, Glu23Lys, and Lys23Lys) of the Glu23Lys polymorphism in the KCNJ11 gene differed significantly (χ2=8.04; p=0.018). The Lys23Lys and Glu23Lys genotypes were statistically more frequently recorded in the hypertension group and the homozygous Glu23Glu genotype was, on the contrary, more common in the control group than in the study one. In the hypertension group, the 23Lys allele frequency was statistically significantly higher than that in the control one (χ2=7.36; p=0.0067). The carriage of the 23Lys allele increased the risk of hypertension by 1.68 times (odds ratio (OR), 1.68; 95% confidence interval (CI), 1.17-2.41), that of the Glu23 allele had, on the contrary, a protective effect (OR, 0.60; 95% CI, 0.41-0.86).
  
  
  CONCLUSIONS
  The polymorphic marker Glu23Lys in the KCNJ11 gene is associated with hypertension in the Kyrgyzes. The 23Lys allele is a marker for the higher risk of hypertension.
authors.affiliation: Institute of Molecular Biology and Medicine, Bishkek, Kyrgyz Republic.
authors.forename: Zh T
authors.initials: ZT
authors.lastname: Isakova
authors.affiliation: Institute of Molecular Biology and Medicine, Bishkek, Kyrgyz Republic.
authors.forename: E T
authors.initials: ET
authors.lastname: Talaibekova
authors.affiliation: Institute of Molecular Biology and Medicine, Bishkek, Kyrgyz Republic.
authors.forename: D A
authors.initials: DA
authors.lastname: Asambaeva
authors.affiliation: National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic.
authors.forename: A S
authors.initials: AS
authors.lastname: Kerimkulova
authors.affiliation: National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic.
authors.forename: O S
authors.initials: OS
authors.lastname: Lunegova
authors.affiliation: Institute of Molecular Biology and Medicine, Bishkek, Kyrgyz Republic.
authors.forename: A A
authors.initials: AA
authors.lastname: Aldashev
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007707:Kyrgyzstan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics*; D000099161:Kcnj11 Channel
chemical_list: D024661:Potassium Channels, Inwardly Rectifying; D000099161:Kcnj11 Channel