title: Development of ocular viscosity characterization method.
abstract: Glaucoma is the second leading cause for blindness. Irreversible and progressive optic nerve damage results when the intraocular pressure (IOP) exceeds 21 mmHg. The elevated IOP is attributed to blocked fluid drainage from the eye. Methods to measure the IOP are widely available, but methods to measure the viscous response to blocked drainage has yet been developed. An indentation method to characterize the ocular flow is developed in this study. Analysis of the load-relaxation data from indentation tests on drainage-controlled porcine eyes showed that the blocked drainage is correlated with increases in ocular viscosity. Successful correlation of the ocular viscosity with drainage suggests that ocular viscosity maybe further developed as a new diagnostic parameter for assessment of normal tension glaucoma where nerve damage occurs without noticeable IOP elevation; and as a diagnostic parameter complimentary to conventional IOP in conventional diagnosis.
authors.lastname: Shu-Hao Lu
authors.lastname: Guo-Zhen Chen
authors.forename: Stanley Y Y
authors.initials: SY
authors.lastname: Leung
authors.forename: David C C
authors.initials: DC
authors.lastname: Lam
mesh_terms: D000818:Animals; D003315:Cornea / Q000502:physiology; D004322:Drainage; D005901:Glaucoma; D009799:Ocular Physiological Phenomena; D012212:Rheology; D034421:Sus scrofa; D014065:Tonometry, Ocular / Q000379:methods*; D014783:Viscosity