title: [Management of mesenteric ischemia in the era of intestinal stroke centers: The gut and lifesaving strategy].
abstract: Mesenteric ischemia is a gut and life-threatening, medical and surgical, digestive and vascular emergency. Mesenteric ischemia is the result of an arterial or venous occlusion, a vasospasm secondary to low-flow states in intensive care patients, aortic clamping during vascular surgery or intestinal transplantation. Progression towards mesenteric infarction and its complications is unpredictable and correlates with high rates of mortality or a high risk of short bowel syndrome in case of survival. Thus, mesenteric ischemia should be diagnosed and treated at an early stage, when gut injury is still reversible. Diagnostic workup lacks sensitive and specific clinical and biological marker. Consequently, diagnosis and effective therapy can be achieved by a high clinical suspicion and a specific multimodal management: the gut and lifesaving strategy. Based on the model of ischemic stroke centers, the need for a multidisciplinary and expert 24/24 emergency care has led, in 2016, to the inauguration of the first Intestinal Stroke Center (Structure d'urgences vasculaires intestinales [SURVI]) in France. This review highlights the pathophysiological features of chronic and acute mesenteric ischemia, as well as the diagnosis workup and the therapeutic management developed in this Intestinal Stroke Center.
authors.affiliation: Structure d'URgences Vasculaires Intestinales (SURVI), service de gastroentérologie, MICI, assistance nutritive et transplantation intestinale, hôpital Beaujon, AP-HP, 100, boulevard du Général-Leclerc, 92110 Clichy, France; Inserm U1148, Laboratory for Vascular Translational Science, hôpital Bichat, 46, rue Henri-Huchard, 75018 Paris, France; Université Paris 7 Diderot, 5, rue Thomas-Mann, 75013 Paris, France. Electronic address: alexandre.nuzzo@aphp.fr.
authors.forename: A
authors.initials: A
authors.lastname: Nuzzo
authors.affiliation: Structure d'URgences Vasculaires Intestinales (SURVI), service de gastroentérologie, MICI, assistance nutritive et transplantation intestinale, hôpital Beaujon, AP-HP, 100, boulevard du Général-Leclerc, 92110 Clichy, France; Inserm U1148, Laboratory for Vascular Translational Science, hôpital Bichat, 46, rue Henri-Huchard, 75018 Paris, France; Université Paris 7 Diderot, 5, rue Thomas-Mann, 75013 Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Corcos
mesh_terms: D003422:Critical Care / Q000379:methods*; D018450:Disease Progression; D005602:France / Q000453:epidemiology; D006801:Humans; D007362:Intensive Care Units / Q000458:organization & administration / Q000592:standards; D007410:Intestinal Diseases / Q000628:therapy*; D007422:Intestines / Q000473:pathology* / Q000502:physiology; D065666:Mesenteric Ischemia / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D020521:Stroke / Q000209:etiology / Q000628:therapy
keywords: Angor mésentérique; Intestinal ischemia; Intestinal stroke centers; Ischémie intestinale; Ischémie mésentérique; Mesenteric angina; Mesenteric ischemia; Urgences vasculaires intestinales