title: Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases.
abstract: Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity.
authors.affiliation: Institute of Pharmacology and Toxicology, Uniklinik RWTH Aachen, Aachen, Germany.
authors.forename: D
authors.identifier: 0000-0002-9702-8581
authors.initials: D
authors.lastname: Dreymueller
authors.affiliation: Department of Pathology, Maastricht University, LK Maastricht, Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: Theodorou
authors.affiliation: Department of Pathology, Maastricht University, LK Maastricht, Netherlands.
authors.forename: M
authors.identifier: 0000-0002-8519-8145
authors.initials: M
authors.lastname: Donners
authors.affiliation: Institute of Pharmacology and Toxicology, Uniklinik RWTH Aachen, Aachen, Germany.
authors.forename: A
authors.identifier: 0000-0001-8536-4986
authors.initials: A
authors.lastname: Ludwig
mesh_terms: D000818:Animals; D002384:Catalysis; D002448:Cell Adhesion; D002465:Cell Movement; D018925:Chemokines / Q000378:metabolism; D002633:Chemotaxis; D003599:Cytoskeleton / Q000378:metabolism; D019483:Disintegrins / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D008024:Ligands; D045726:Metalloproteases / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000473:pathology; D018919:Neovascularization, Physiologic; D014945:Wound Healing
chemical_list: D018925:Chemokines; D019483:Disintegrins; D008024:Ligands; D045726:Metalloproteases