title: Chemotherapy-related cognitive impairment or « chemobrain »: concept and state of art.
abstract: Cognitive complaints are frequent in patients who received chemotherapy for a non-CNS cancer. These observations have been described as « chemobrain ». However, studies results are contradictory concerning the implication of chemotherapy in the onset of cognitive defects. Moreover, other factors as mood, anxiety and fatigue are often associated in this population and could be confounding. This article present principal results of research in human experiencing chemobrain, concerning clinical presentation, neuropsychological examination, imaging techniques and treatment possibilities. Physiopathological hypothesis are presented. The implication of hormonotherapy is also discussed.
authors.affiliation: Service de neurologie, Service de santé des armées, HIA de Percy, Clamart, France.
authors.forename: Flavie
authors.initials: F
authors.lastname: Bompaire
authors.affiliation: Service de neurologie 2, Hôpital de la Pitié-Salpêtrière, Paris, France, UMR MD4 8257 CNRS, Université Paris Descartes, SSA, Paris, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Durand
authors.affiliation: Pôle immunologie-infectiologie-inflammation-endocrinologie I3E/USR, Hôpital Bicêtre, Le Kremlin-Bicêtre, France, UMR 1086 Inserm, Centre régional de lutte contre le cancer François Baclesse, Caen, France, Institut Gustave Roussy, Villejuif, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Léger-Hardy
authors.affiliation: Service de neurologie 2, Hôpital de la Pitié-Salpêtrière, Paris, France.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Psimaras
authors.affiliation: Service de neurologie, Service de santé des armées, HIA de Percy, Clamart, France, UMR MD4 8257 CNRS, Université Paris Descartes, SSA, Paris, France, Ecole du Val-de-Grâce, Service de santé des armées, Paris, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Ricard
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003072:Cognition Disorders / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D006801:Humans; D009483:Neuropsychological Tests
chemical_list: D000970:Antineoplastic Agents
keywords: cancer; chemobrain; chemotherapy; hormonotherapy