title: Predicting the presence of colon cancer in members of a health maintenance organisation by evaluating analytes from standard laboratory records.
abstract: BACKGROUND
  A valid risk prediction model for colorectal cancer (CRC) could be used to identify individuals in the population who would most benefit from CRC screening. We evaluated the potential for information derived from a panel of blood tests to predict a diagnosis of CRC from 1 month to 3 years in the future.
  
  
  METHODS
  We abstracted information on 1755 CRC cases and 54 730 matched cancer-free controls who had one or more blood tests recorded in the electronic records of Maccabi Health Services (MHS) during the period 30-180 days before diagnosis. A scoring model (CRC score) was constructed using the study subjects' blood test results. We calculated the odds ratio for being diagnosed with CRC after the date of blood draw, according to CRC score and time from blood draw.
  
  
  RESULTS
  The odds ratio for having CRC detected within 6 months for those with a score of four or greater (vs three or less) was 7.3 (95% CI: 6.3-8.5) for men and was 7.8 (95% CI: 6.7-9.1) for women.
  
  
  CONCLUSIONS
  Information taken from routine blood tests can be used to predict the risk of being diagnosed with CRC in the near future.
authors.affiliation: Medial Early Sign, Kfar Malal, Israel.
authors.forename: Ran
authors.initials: R
authors.lastname: Goshen
authors.affiliation: Medial Research, Kfar Malal, Israel.
authors.forename: Barak
authors.initials: B
authors.lastname: Mizrahi
authors.affiliation: Medial Research, Kfar Malal, Israel.
authors.forename: Pini
authors.initials: P
authors.lastname: Akiva
authors.affiliation: Medial Research, Kfar Malal, Israel.
authors.forename: Yaron
authors.initials: Y
authors.lastname: Kinar
authors.affiliation: Medial Early Sign, Kfar Malal, Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Choman
authors.affiliation: Institute of Health Research and Innovation, Maccabi Healthcare Services, Tel-Aviv, Israel.
authors.forename: Varda
authors.initials: V
authors.lastname: Shalev
authors.affiliation: Familial Breast Cancer Research Unit, Women's College Research Institute, Women's College Hospital, 76 Grenville Street, 6th Floor, Suite 6420, Toronto, ON, Canada M5S 1B2.
authors.forename: Victoria
authors.initials: V
authors.lastname: Sopik
authors.affiliation: Department of Gastroenterology, Souraski Medical Centre, Tel-Aviv, Israel.|Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
authors.forename: Revital
authors.initials: R
authors.lastname: Kariv
authors.affiliation: Familial Breast Cancer Research Unit, Women's College Research Institute, Women's College Hospital, 76 Grenville Street, 6th Floor, Suite 6420, Toronto, ON, Canada M5S 1B2.|Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D019411:Clinical Laboratory Techniques / Q000592:standards*; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D055088:Early Detection of Cancer; D057286:Electronic Health Records / Q000592:standards*; D005260:Female; D005500:Follow-Up Studies; D006279:Health Maintenance Organizations; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D000078329:Workforce