title: Analysis of "Randomized Cross-Over Study Comparing Two Infusion Sets for CSII in Daily Life".
abstract: In an article in Journal of Diabetes Science and Technology, Freckmann et al report an evaluation of 2 infusion sets used for CSII in daily life, both from Roche. Because the 2 catheters differed at the soft cannula level in terms of geometry and introducer needle, focus was made on pain at insertion. While no significant difference was noted on this primary endpoint, unplanned catheter changes occurred in close to 20% of cases also with both catheter models, mainly driven by apparent insulin delivery issues. Since kinked cannulas were not frequent, there is a clear need for better understanding of "unexplained hyperglycemia" as the main reason for reduction of catheter lifetime. Fixing this weak aspect of CSII becomes crucial while moving toward closed-loop insulin delivery.
authors.affiliation: 1 Department of Endocrinology, Montpellier University Hospital, Diabetes, Nutrition, Montpellier, France.|2 Clinical Investigation Centre, INSERM CIC 1411, University of Montpellier, Montpellier, France.|3 Institute of Functional Genomics, CNRS UMR 5203, INSERM U1191, University of Montpellier, Montpellier, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Renard
mesh_terms: D006801:Humans; D001786:Blood Glucose; D018592:Cross-Over Studies; D003922:Diabetes Mellitus, Type 1; D007328:Insulin; D007332:Insulin Infusion Systems; D016032:Randomized Controlled Trials as Topic; D015337:Multicenter Studies as Topic; D017326:Clinical Trials, Phase III as Topic
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: CSII; diabetes; infusion set; insulin pump