title: Quetiapinev.lithium in the maintenance phase following a first episode of mania: randomised controlled trial.
abstract: BackgroundLithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their efficacy compares with each other.AimsTo investigate the differential effect of lithium and quetiapine on symptoms of depression, mania, general functioning, global illness severity and quality of life in patients with recently stabilised first-episode mania.MethodMaintenance trial of patients with first-episode mania stabilised on a combination of lithium and quetiapine, subsequently randomised to lithium or quetiapine monotherapy (up to 800 mg/day) and followed up for 1 year. (Trial registration: Australian and New Zealand Clinical Trials Registry - ACTRN12607000639426.)ResultsIn total, 61 individuals were randomised. Within mixed-model repeated measures analyses, significant omnibus treatment × visit interactions were observed for measures of overall psychopathology, psychotic symptoms and functioning. Planned andpost hoccomparisons further demonstrated the superiority of lithium treatment over quetiapine.ConclusionsIn people with first-episode mania treated with a combination of lithium and quetiapine, continuation treatment with lithium rather than quetiapine is superior in terms of mean levels of symptoms during a 1-year evolution.
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia mikebe@barwonhealth.org.au.
authors.forename: Michael
authors.initials: M
authors.lastname: Berk
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Rothanthi
authors.initials: R
authors.lastname: Daglas
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Orwa
authors.initials: O
authors.lastname: Dandash
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Murat
authors.initials: M
authors.lastname: Yücel
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Lisa
authors.initials: L
authors.lastname: Henry
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Karen
authors.initials: K
authors.lastname: Hallam
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Craig
authors.initials: C
authors.lastname: Macneil
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Melissa
authors.initials: M
authors.lastname: Hasty
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Christos
authors.initials: C
authors.lastname: Pantelis
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Brendan P
authors.initials: BP
authors.lastname: Murphy
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Linda
authors.initials: L
authors.lastname: Kader
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Saji
authors.initials: S
authors.lastname: Damodaran
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Michael T H
authors.initials: MTH
authors.lastname: Wong
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Philippe
authors.initials: P
authors.lastname: Conus
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Aswin
authors.initials: A
authors.lastname: Ratheesh
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: McGorry
authors.affiliation: Michael Berk, MBBCh, PhD, Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health and the Geelong Clinic; Orygen, The National Centre of Excellence in Youth Mental Health, the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Victoria, Australia; Rothanthi Daglas, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Orwa Dandash, PhD, Murat Yücel, PhD, Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences (MICCN), School of Psychological Sciences, Monash University, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia; Lisa Henry, MPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Karen Hallam, PhD, Division of Psychology, School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; Craig Macneil, DPsych, Melissa Hasty, DPsych, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Christos Pantelis, MD, Hon MD (Athens), Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Brendan P. Murphy, FRCPsych, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Linda Kader, MD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia; Saji Damodaran, MD, Michael T. H. Wong, MD, PhD, Department of Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Philippe Conus, MD, Département Universitaire de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland; Aswin Ratheesh, MD, Patrick D. McGorry, MD, PhD, Sue M. Cotton, PhD, Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.
authors.forename: Sue M
authors.initials: SM
authors.lastname: Cotton
mesh_terms: D000293:Adolescent; D000328:Adult; D018692:Antimanic Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D018020:Lithium Compounds / Q000627:therapeutic use*; D008297:Male; D011788:Quality of Life; D000069348:Quetiapine Fumarate / Q000627:therapeutic use*; D016037:Single-Blind Method; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018692:Antimanic Agents; D014150:Antipsychotic Agents; D018020:Lithium Compounds; D000069348:Quetiapine Fumarate