title: Utility of serum periostin in combination with exhaled nitric oxide in the management of asthma.
abstract: Type-2/eosinophilic inflammation plays a pivotal role in asthma. The identification of severe type-2/eosinophilic asthma is important for improving the management of patients with asthma. Therefore, efforts to develop non-invasive biomarkers for type-2/eosinophilic airway inflammation have been made during this decade. Currently, fraction of exhaled nitric oxide (FeNO) and serum periostin levels are considered markers of type-2/eosinophilic inflammation in asthma. However, a single-marker approach has limited the ability to diagnose severe type-2/eosinophilic asthma accurately and predict disease outcomes precisely. The present article reviews the utility of FeNO and serum periostin levels in a single-marker approach and in a multiple-marker approach in identifying patients with severe type-2/eosinophilic asthma. Furthermore, based on a sub-analysis of the Kinki Hokuriku Airway disease Conference (KiHAC), geno-endo-phenotypes of patients were stratified into four groups according to the FeNO and serum periostin levels.
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Tadao
authors.initials: T
authors.lastname: Nagasaki
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: hmatsumo@kuhp.kyoto-u.ac.jp.
authors.forename: Hisako
authors.initials: H
authors.lastname: Matsumoto
authors.affiliation: Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Izuhara
mesh_terms: D000818:Animals; D001249:Asthma / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D015415:Biomarkers; D001944:Breath Tests; D015815:Cell Adhesion Molecules / Q000097:blood*; D019468:Disease Management; D018450:Disease Progression; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D045853:Exhalation; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D011379:Prognosis; D012129:Respiratory Function Tests
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; C512835:POSTN protein, human; D009569:Nitric Oxide
keywords: Asthma; Composite marker; Nitric oxide; Serum periostin; Type-2/eosinophilic inflammation