title: Management of aromatase inhibitor induced musculoskeletal symptoms in postmenopausal early Breast cancer: A systematic review and meta-analysis.
abstract: Aromatase Inhibitors (AI) are widely used for the adjuvant treatment of hormone receptor positive breast cancers in the post-menopausal population. AI are often associated with significant joint and muscular symptoms; symptoms that are commonly referred to as aromatase inhibitor-associated musculoskeletal syndrome (AIMSS). AIMSS adversely impacts health-related quality of life of many patients, and reduces AI compliance. Although there are informal practice recommendations, the limited current level of evidence for management of AIMSS for breast cancer patients on aromatase inhibitors has made development of formal guidelines challenging, and remains an unmet need. This is the first systematic review to consider the evidence for all pharmacological and non-pharmacological interventions in the treatment of AIMSS, including physical therapy, acupuncture and complementary therapies.
authors.affiliation: Department of Medical Oncology, Mater Health Services, Brisbane, Australia. Electronic address: Kate.Roberts@health.qld.gov.au.
authors.forename: Kate
authors.initials: K
authors.lastname: Roberts
authors.affiliation: University of Queensland, Brisbane, Australia.
authors.forename: Kirsty
authors.initials: K
authors.lastname: Rickett
authors.affiliation: University of Queensland, Brisbane, Australia; Mater Medical Research Institute Mater Health Services, Brisbane, Australia.
authors.forename: Ristan
authors.initials: R
authors.lastname: Greer
authors.affiliation: Department of Medical Oncology, Mater Health Services, Brisbane, Australia; University of Queensland, Brisbane, Australia; Mater Medical Research Institute Mater Health Services, Brisbane, Australia.
authors.forename: Natasha
authors.initials: N
authors.lastname: Woodward
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects / Q000627:therapeutic use; D047072:Aromatase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D019468:Disease Management; D005260:Female; D006801:Humans; D009140:Musculoskeletal Diseases / Q000139:chemically induced* / Q000628:therapy*; D017698:Postmenopause; D011788:Quality of Life
chemical_list: D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors
keywords: AIMSS; Anastrozole; Aromatase inhibitors; Arthralgias; Breast cancer; Exemestane; Letrozole; Musculoskeletal symptoms