title: [Pathogenesis and genetic landscape of acute myeloid leukemia].
abstract: The recent advances in the field of molecular biology have enabled a more comprehensive genomic analysis in myeloid malignancies. The studies have unveiled recurrent somatic mutations in several genes illuminating the clinical heterogeneity of these diseases. In this review, we discuss the pathogenesis of de novo and secondary acute myeloid leukemia (AML) in view of recent findings. Mutational analysis of several genes are already included in the everyday diagnostic procedure of AML. The identification of these mutations enables improvements in risk-stratification strategies and provides new potential targets for treatment of AML.
authors.affiliation: I. Sz. Patológiai és Kísérleti Rákkutató Intézet, Semmelweis Egyetem, Budapest, Hungary. rajnai.hajnalka@med.semmelweis-univ.hu.
authors.forename: Hajnalka
authors.initials: H
authors.lastname: Rajnai
authors.affiliation: I. Sz. Patológiai és Kísérleti Rákkutató Intézet, Semmelweis Egyetem, Budapest, Hungary. rajnai.hajnalka@med.semmelweis-univ.hu.
authors.forename: Attila Péter
authors.initials: AP
authors.lastname: Király
mesh_terms: D004252:DNA Mutational Analysis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D009154:Mutation; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology