title: CD19(+)CD56(-)myeloma arising in a patient who failed two courses of immunosupressive therapy for aplastic anaemia.
abstract: Patients diagnosed with severe aplastic anaemia and without a compatible bone marrow transplant donor are treated with immunosuppressive therapy. These patients are found with time to develop a clonal disease such as myelodysplasia or paroxysmal nocturnal haemoglobinuria. However, the development of plasma cell dyscrasias is rare. We report the case here of a patient treated with immunosuppressive therapy who went on to develop myeloma 11 months after being diagnosed with severe aplastic anaemia. We include here a review of the literature.
authors.affiliation: Service of Medicine, Hospital Carabineros of Chile, Nuñoa, 7770199 Santiago, Chile; Faculty of Medicine, University Finis Terrae, Providencia, 7501015 Santiago, Chile.
authors.forename: Nigel P
authors.initials: NP
authors.lastname: Murray
authors.affiliation: Service of Pathology, Hospital Carabineros of Chile, Nuñoa, 7770199 Santiago, Chile.
authors.forename: M Amparo
authors.initials: MA
authors.lastname: Ruiz
authors.affiliation: Service of Medicine, Hospital Carabineros of Chile, Nuñoa, 7770199 Santiago, Chile.
authors.forename: G Maximiliano
authors.initials: GM
authors.lastname: Miranda
keywords: aplastic anemia; immunosuppressive therapy; myeloma