title: Antinociceptive action ofVanillosmopsis arboreain male mice.
abstract: OBJECTIVE
  Vanillosmopsis arboreaBaker (Asteraceae) has high economic value from Chapada to Araripe and its bark essential oil is a potential source of alpha-bisabolol. The present study aimed to elucidate the antinociceptive and antipruritic properties of the essential oil ofV. arboreaBaker (EOVA) in mice.
  
  
  METHODS
  The antinociceptive activity was assessed using the capsaicin, glutamate, hot plate and cold allodynia tests. The antipuritic effects were also verified based on histamine-induced scratching behavior.
  
  
  RESULTS
  EOVA reduced the paw licking induced by capsaicin, but not that induced by glutamate. The essential oil increased the latency time in the hot plate, attenuated the cold allodynia induced by acetone and inhibited histamine-induced scratching behavior.
  
  
  CONCLUSIONS
  The experimental data demonstrated that EOVA showed central and peripheral antinociceptive activity and antipruritic effect.
authors.affiliation: Department of Biology at the Federal University of Cariri, Brejo Santo - CE, Brazil.
authors.forename: Laura Inocencio
authors.initials: LI
authors.lastname: Leite
authors.affiliation: Department of Pharmacology, University of Santa Maria, Santa Maria- RS, Brazil.
authors.forename: Gerlânia de Oliveira
authors.initials: GO
authors.lastname: Leite
authors.affiliation: Department of Chemical Biological at the Regional University of Cariri, Crato - CE, Brazil.
authors.forename: Bruno Anderson
authors.initials: BA
authors.lastname: Fernandes Silva
authors.affiliation: Department of Chemical Biological at the Regional University of Cariri, Crato - CE, Brazil.
authors.forename: Severino Denício
authors.initials: SD
authors.lastname: Gonçalves Sousa
authors.affiliation: Department of Chemical Biological at the Regional University of Cariri, Crato - CE, Brazil.
authors.forename: Thales Silva
authors.initials: TS
authors.lastname: Coutinho
authors.affiliation: Department of Chemical Biological at the Regional University of Cariri, Crato - CE, Brazil.
authors.forename: Renata Souza
authors.initials: RS
authors.lastname: Sampaio
authors.affiliation: Department of Chemical Biological at the Regional University of Cariri, Crato - CE, Brazil.
authors.forename: Irwin
authors.initials: I
authors.lastname: Menezes
authors.affiliation: Department of Chemical Biological at the Regional University of Cariri, Crato - CE, Brazil.
authors.forename: José Galberto
authors.initials: JG
authors.lastname: Martins Costa
authors.affiliation: Department of Pharmacology at the University of Fortaleza, Fortaleza - CE, Brazil.
authors.forename: Adriana Rolim
authors.initials: AR
authors.lastname: Campos
keywords: Antinociceptive; Antipruritic; Essential oil; Vanillosmopsisarborea