title: Follow up in women with biopsy diagnosis of cervical low-grade squamous intraepithelial lesion (LSIL): how long should it be?
abstract: OBJECTIVE
  To analyse the regression rate and the risk of persistence or progression of the lesions in women with a histopathological diagnosis of cervical low-grade squamous intraepithelial lesion (LSIL).
  
  
  METHODS
  Retrospective cohort study of women with biopsy diagnosis of cervical LSIL, from January 2010 to December 2013. After the initial diagnosis of LSIL, all the women underwent scheduled follow-up examinations with cytology every 6 months for 2 years and an HPV test after 1 year.
  
  
  RESULTS
  At the 24 -month follow-up, the regression of cervical LSIL was observed in 88.5% of the women. 10.8% of the women had a persistent lesion, while a progression towards cervical HSIL was reported in 0.7% of the women. The risk of persistence or progression of histological LSIL was higher in women with ASC-H or HSIL on the referral cytology and in tobacco users.
  
  
  CONCLUSIONS
  In women with biopsy diagnosis of cervical LSIL, preceded by ASCUS or LSIL on cytology, a high rate of regression was observed and, in most of the cases, the regression occurred in the first year of follow-up. In women with cervical LSIL, preceded by ASC-H or HSIL on cytology, and in tobacco users, a higher risk of persistence and progression was observed. Thus, in these cases, repeated follow-up examinations, even with the HR-HPV test, are advisable.
authors.affiliation: Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Via F. Corridoni 11, 60123, Ancona, Italy. ciavattini.a@libero.it.
authors.forename: Andrea
authors.identifier: http://orcid.org/0000-0003-0074-5996
authors.initials: A
authors.lastname: Ciavattini
authors.affiliation: Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Via F. Corridoni 11, 60123, Ancona, Italy.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Clemente
authors.affiliation: Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Via F. Corridoni 11, 60123, Ancona, Italy.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Tsiroglou
authors.affiliation: Gynecological Oncology Unit, CRO Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Sopracordevole
authors.affiliation: Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Via F. Corridoni 11, 60123, Ancona, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Serri
authors.affiliation: Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Via F. Corridoni 11, 60123, Ancona, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Delli Carpini
authors.affiliation: Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Via F. Corridoni 11, 60123, Ancona, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Papiccio
authors.affiliation: Center for Gynecologic Oncology Prevention, ULSS 20, Verona, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Cattani
mesh_terms: D000328:Adult; D001706:Biopsy; D002985:Clinical Protocols; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking; D065310:Squamous Intraepithelial Lesions of the Cervix / Q000473:pathology*; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000473:pathology*
keywords: CIN1; Cervical intraepithelial neoplasia; Follow-up; LSIL; Persistence; Regression