title: Do Hearing Aids Influence Behavioral and Psychological Symptoms of Dementia and Quality of Life in Hearing Impaired Alzheimer's Disease Patients and Their Caregivers?
abstract: It has been suggested that age-related hearing loss (ARHL) and Alzheimer's disease (AD) are commonly associated.
  
  
  
  The Alzheimer Disease, Presbycusis and Hearing Aids (ADPHA) clinical trial assessed the influence of hearing aids (HAs) on patients affected by ARHL and AD, as judged by behavioral symptoms and functional abilities, as well as patient and caregiver quality of life (QoL).
  
  
  
  A multicenter double-blind randomized placebo-controlled trial, with a semi-crossover procedure over 12 months, was conducted from 2006 to 2012. For the first 6 months, the active group was treated with active HAs and the placebo group with inactive HAs. For the last 6 months, HAs in the placebo group were activated. Assessment was conducted at baseline, 6 months, and 12 months. We performed intergroup and intragroup comparisons. Behavioral symptoms were assessed by neuropsychiatric inventory (NPI), functional abilities by instrumental activities of daily living, and QoL by Zarit, Alzheimer's disease related quality of life, and simplified Duke scales.
  
  
  
  Fifty-one patients were included and randomized: 22 in active group (mean NPI 17.6; mean age 83±6.2) and 26 in placebo group (mean NPI 25.8; mean age 82.3±7.2) were fitted with HAs. At 6-month follow-up, all scores worsened without significant difference between the two groups. In placebo group, activation of HAs had no effect on the change of these scores.
  
  
  
  These findings do not provide evidence of improvement in behavioral symptoms, functional status, or QoL of hearing impaired AD patients and their caregivers after 6 months of HA use. However, we cannot exclude that HAs may have a positive effect in patients aged less than 75 years.
authors.affiliation: Geriatric Medicine Unit, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, Université Claude Bernard, Lyon1, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Adrait
authors.affiliation: Institute of Sciences and Techniques for Rehabilitation (ISTR), Université Claude Bernard, Lyon1, France.|Department of Audiology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Perrot
authors.affiliation: Geriatric Medicine Unit, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, Université Claude Bernard, Lyon1, France.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Nguyen
authors.affiliation: Clinical Research Unit, Pole IMER, Hospices Civils de Lyon, Lyon, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Gueugnon
authors.affiliation: Geriatric Medicine Unit, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, Université Claude Bernard, Lyon1, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Petitot
authors.affiliation: Department of Audiology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Collet
authors.affiliation: Clinical Research Unit, Pole IMER, Hospices Civils de Lyon, Lyon, France.
authors.forename: Adeline
authors.initials: A
authors.lastname: Roux
authors.affiliation: Geriatric Medicine Unit, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, Université Claude Bernard, Lyon1, France.|INSERM 1060.
authors.forename: Marc
authors.initials: M
authors.lastname: Bonnefoy
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology / Q000523:psychology*; D017028:Caregivers / Q000523:psychology*; D003704:Dementia / Q000503:physiopathology / Q000523:psychology*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006310:Hearing Aids / Q000523:psychology; D034381:Hearing Loss / Q000209:etiology / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D017063:Outcome Assessment, Health Care; D010349:Patient Compliance; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life / Q000523:psychology*; D012189:Retrospective Studies; D013997:Time Factors
keywords: Age-related hearing loss; Alzheimer’s disease; behavioral symptoms; hearing aids