title: Potentiation of motor sub-networks for motor control but not working memory: Interaction of dACC and SMA revealed by resting-state directed functional connectivity.
abstract: The dorsal Anterior Cingulate Cortex (dACC) and the Supplementary Motor Area (SMA) are known to interact during motor coordination behavior. We previously discovered that the directional influences underlying this interaction in a visuo-motor coordination task are asymmetric, with the dACC→SMA influence being significantly greater than that in the reverse direction. To assess the specificity of this effect, here we undertook an analysis of the interaction between dACC and SMA in two distinct contexts. In addition to the motor coordination task, we also assessed these effects during a (n-back) working memory task. We applied directed functional connectivity analysis to these two task paradigms, and also to the rest condition of each paradigm, in which rest blocks were interspersed with task blocks. We report here that the previously known asymmetric interaction between dACC and SMA, with dACC→SMA dominating, was significantly larger in the motor coordination task than the memory task. Moreover the asymmetry between dACC and SMA was reversed during the rest condition of the motor coordination task, but not of the working memory task. In sum, the dACC→SMA influence was significantly greater in the motor task than the memory task condition, and the SMA→dACC influence was significantly greater in the motor rest than the memory rest condition. We interpret these results as suggesting that the potentiation of motor sub-networks during the motor rest condition supports the motor control of SMA by dACC during the active motor task condition.
authors.affiliation: Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, United States of America.
authors.forename: Vaibhav A
authors.initials: VA
authors.lastname: Diwadkar
authors.affiliation: Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, Florida, United States of America.
authors.forename: Avisa
authors.initials: A
authors.lastname: Asemi
authors.affiliation: Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, United States of America.
authors.forename: Ashley
authors.initials: A
authors.lastname: Burgess
authors.affiliation: Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, United States of America.
authors.forename: Asadur
authors.initials: A
authors.lastname: Chowdury
authors.affiliation: Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, Florida, United States of America.|Department of Psychology, Florida Atlantic University, Boca Raton, Florida, United States of America.
authors.forename: Steven L
authors.initials: SL
authors.lastname: Bressler
mesh_terms: D001931:Brain Mapping; D063132:Connectome; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008570:Memory, Short-Term / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000502:physiology*; D009434:Neural Pathways; D012146:Rest / Q000502:physiology*; D013647:Task Performance and Analysis