title: Shorter leukocyte telomere length in patients at ultra high risk for psychosis.
abstract: Telomere length attrition has been demonstrated in schizophrenia but not in individuals in ultra high risk (UHR) for psychosis. The present study aimed to compare the leukocyte telomere length (TL) between patients at UHR for psychosis and healthy controls (HC). Twenty-two participants with UHR and 88 HC were enrolled in this study. Telomere lengths were determined using a multiplex qPCR assay. After adjustment for age, sex, ethnicity, and education, patients in UHR, compared with HC groups, had shorter telomere length (RR: 0.929, p=0.031). Shorter leukocyte telomere length in UHR could represent early signs of accelerated aging in this population.
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, India.
authors.forename: Pawan Kumar
authors.initials: PK
authors.lastname: Maurya
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Research Group on Behavioral and Molecular Neuroscience of Bipolar Disorder, São Paulo, Brazil; Department of Psychiatry, University of Tübingen, Tübingen, Germany.
authors.forename: Lucas Bortolotto
authors.initials: LB
authors.lastname: Rizzo
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Departamento de Morfologia e Genética, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Xavier
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil.
authors.forename: Priscila Farias
authors.initials: PF
authors.lastname: Tempaku
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Department of Psychiatry, University of Tübingen, Tübingen, Germany; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil.
authors.forename: Maiara
authors.initials: M
authors.lastname: Zeni-Graiff
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Departamento de Morfologia e Genética, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil.
authors.forename: Marcos L
authors.initials: ML
authors.lastname: Santoro
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil.
authors.forename: Diego Robles
authors.initials: DR
authors.lastname: Mazzotti
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil.
authors.forename: André
authors.initials: A
authors.lastname: Zugman
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil.
authors.forename: Pedro
authors.initials: P
authors.lastname: Pan
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Noto
authors.affiliation: Graduation Program in Health Sciences, Universidade Estadual de Londrina, Londrina, PR, Brazil; Department of Psychiatry, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Michael
authors.initials: M
authors.lastname: Maes
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil.
authors.forename: Elson
authors.initials: E
authors.lastname: Asevedo
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil; Mood Disorders Psychopharmacology Unit (MDPU), University Health Network (UHN), University of Toronto, Toronto, Canada.
authors.forename: Rodrigo B
authors.initials: RB
authors.lastname: Mansur
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil.
authors.forename: Graccielle R
authors.initials: GR
authors.lastname: Cunha
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil.
authors.forename: Ary
authors.initials: A
authors.lastname: Gadelha
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil.
authors.forename: Rodrigo A
authors.initials: RA
authors.lastname: Bressan
authors.affiliation: Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Departamento de Morfologia e Genética, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil.
authors.forename: Sintia Iole
authors.initials: SI
authors.lastname: Belangero
authors.affiliation: Research Group on Behavioral and Molecular Neuroscience of Bipolar Disorder, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil. Electronic address: elisabrietzke@hotmail.com.
authors.forename: Elisa
authors.initials: E
authors.lastname: Brietzke
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000473:pathology*; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000235:genetics* / Q000473:pathology*; D059506:Telomere Shortening / Q000502:physiology*; D055815:Young Adult
keywords: Psychosis; Schizophrenia; Telomere; Ultra-high risk