title: Scope of Lipid Nanoparticles in Neuroscience: Impact on the Treatment of Neurodegenerative Diseases.
abstract: Lipid nanoparticles have been studied mainly as a means of transporting and releasing drugs. A special emphasis has been placed on designing nanoparticles that improve the delivery of drugs with targets in the central nervous system.
  
  
  
  The biomedical literature was searched for basic and clinical studies. The recent applications are described and related with their bioactivities.
  
  
  
  The current review compiles data on the components and features of lipid nanoparticle systems as well as the necessary conditions for their selective action. As an example of their application, we present data from preclinical and clinical studies on lipid nanoparticles used as potent and efficient agents in the diagnosis and treatment of some neurodegenerative maladies, including Parkinson's disease.
  
  
  
  Current evidence supports the application of lipid nanoparticles for designing drugs carriers for neurodegenerative diseases. Also, we have gathered data that suggests a role of drug-free lipid nanoparticles as neuroprotective or preventive agents during neurodegenerative processes.
authors.affiliation: Departamentos de Fisiología Humana y Bioquímica Médica Sección de Estudios de Posgrado e Investigación. Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, Ciudad de México. Mexico.
authors.forename: Segura-Uribe Julia
authors.initials: SJ
authors.lastname: J
authors.affiliation: Departamentos de Fisiología Humana y Bioquímica Médica Sección de Estudios de Posgrado e Investigación. Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, Ciudad de México. Mexico.
authors.forename: Ciprés-Flores Fabiola
authors.initials: CF
authors.lastname: Jimena
authors.affiliation: Departamentos de Fisiología Humana y Bioquímica Médica Sección de Estudios de Posgrado e Investigación. Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, Ciudad de México. Mexico.
authors.forename: Farfán-García Eunice
authors.initials: FE
authors.lastname: Dalet
authors.affiliation: Departamentos de Fisiología Humana y Bioquímica Médica Sección de Estudios de Posgrado e Investigación. Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, Ciudad de México. Mexico.
authors.forename: Trujillo-Ferrara José
authors.initials: TJ
authors.lastname: Guadalupe
authors.affiliation: Departamento de Fisiología, Escuela Superior de Medicina, Instituto Politécnico Nacional. Plan de San Luis y Díaz Mirón, C.P. 11340, Ciudad de México. Mexico.
authors.forename: Soriano-Ursúa Marvin
authors.initials: SM
authors.lastname: Antonio
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D008055:Lipids / Q000008:administration & dosage / Q000627:therapeutic use*; D053758:Nanoparticles; D019636:Neurodegenerative Diseases / Q000188:drug therapy*
chemical_list: D008055:Lipids
keywords: Central nervous system; Parkinson&apos;s disease.; drug delivery; nanoliposomes; nanoparticles; neurodegenerative disease