title: Application of new ZnO nanoformulation and Ag/Fe/ZnO nanocomposites as water-based nanofluids to consider in vitro cytotoxic effects against MCF-7 breast cancer cells.
abstract: Novel formulations of nanocomposites derived from ZnO nanoparticles have provided potential biomedical applications as a new strategy for treatment of breast cancer. In this research, two types of ZnO nanomaterials were synthesized by sol-gel hydrothermal process and co-precipitation containing fast quenching and also surface modification methods. The cytotoxic effects on growth of the breast cancer cell lines MCF-7 were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Cell viability of the breast cancer cell line MCF-7 was reduced with increasing ZnO nanofluid concentrations at 48 and 72 h of treatment. The IC50value of MCF-7 cells after 72 h of treatment with the first product ZnO (a) and second one ZnO
authors.affiliation: a Cellular and Molecular Research Center , Qom University of Medical Sciences , Qom , Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Abdolmohammadi
authors.affiliation: a Cellular and Molecular Research Center , Qom University of Medical Sciences , Qom , Iran.
authors.forename: Faranak
authors.initials: F
authors.lastname: Fallahian
authors.affiliation: b School of Chemical Engineering, College of Engineering , University of Tehran , Tehran , Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Fakhroueian
authors.affiliation: c University of Tehran , Alborz Campus , Karaj , Iran.
authors.forename: Mozhgan
authors.initials: M
authors.lastname: Kamalian
authors.affiliation: d Nanophthalmology Lab, Stem Cell Preparation Unit, Eye Research Center , Farabi Hospital, Tehran University of Medical Sciences , Tehran , Iran.|e Convergence of Knowledge, Technology and Society Network (CKTSN) , Universal Scientific Education and Research Network (USERN) , Tehran , Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Keyhanvar
authors.affiliation: f Department of Cell Biology and Biochemistry, Cancer Center , Texas Tech University Health Sciences Center , Lubbock , TX , USA.
authors.forename: Faraz
authors.initials: F
authors.lastname: M Harsini
authors.affiliation: g Department of Physics , Alzahra University , Tehran, Iran.|h School of Physics , IPM , Tehran , Iran.
authors.forename: Azizollah
authors.initials: A
authors.lastname: Shafiekhani
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004339:Drug Compounding; D006801:Humans; D007501:Iron / Q000737:chemistry*; D061986:MCF-7 Cells; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D014867:Water / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D014867:Water; D012834:Silver; D007501:Iron; D015034:Zinc Oxide
keywords: Modification of surface; breast cancer cell lines MCF-7; high trapping states; hydrophilic ZnO nanosurface; normal human fibroblast cell MRC-5; synergistic effect; wide bandgap energy