title: Relationship between myocardial performance index and severity of coronary artery disease in patients with non-ST-segment elevation acute coronary syndrome.
abstract: OBJECTIVE
  We aimed to investigate the relationship between myocardial performance index (MPI) and severity of coronary artery disease, as assessed by the Gensini score (GS), in patients with non-ST-segment elevation myocardial infarction (NSTEMI).
  
  
  METHODS
  Ninety patients with an initial diagnosis of NSTEMI were enrolled in our study. They were divided into tertiles according to the GS: low GS < 19; mid GS > 19 and ≤ 96; and high GS > 96.
  
  
  RESULTS
  The low-, mid- and high-GS groups included 24, 38 and 28 patients, respectively. Clinical features such as gender distribution; body mass index (BMI); prevalence of diabetes mellitus, hypertension and hyperlipidaemia; and smoking status were similar in the three groups. MPI and isovolumic relaxation time were significantly higher in the high-GS group than in the low- and mid-GS groups (p < 0.001 and p = 0.005, respectively). Furthermore, the high-GS group had a significantly lower ejection fraction and ejection time (p = 0.01 and p < 0.001, respectively). MPI was positively correlated with the GS (r = 0.47, p < 0.001), and multivariate regression analysis showed that MPI was an independent predictor of the GS (β = 0.358, p < 0.001).
  
  
  CONCLUSIONS
  Patients with NSTEMI who fall within the high-risk group may be identified by means of a simple MPI measurement.
authors.affiliation: Department of Cardiology, Cardiology Institute of Istanbul University, Istanbul, Turkey. Email: drokayabaci@hotmail.com.
authors.forename: Okay
authors.initials: O
authors.lastname: Abaci
authors.affiliation: Department of Cardiology, Cardiology Institute of Istanbul University, Istanbul, Turkey.
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Kocas
authors.affiliation: Department of Cardiology, Cardiology Institute of Istanbul University, Istanbul, Turkey.
authors.forename: Veysel
authors.initials: V
authors.lastname: Oktay
authors.affiliation: Department of Cardiology, Cardiology Institute of Istanbul University, Istanbul, Turkey.
authors.forename: Sukru
authors.initials: S
authors.lastname: Arslan
authors.affiliation: Department of Cardiology, Cardiology Institute of Istanbul University, Istanbul, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Turkmen
authors.affiliation: Department of Cardiology, Cardiology Institute of Istanbul University, Istanbul, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Bostan
authors.affiliation: Department of Cardiology, Cardiology Institute of Istanbul University, Istanbul, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Coskun
authors.affiliation: Department of Cardiology, Cardiology Institute of Istanbul University, Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yildiz
authors.affiliation: Department of Cardiology, Cardiology Institute of Istanbul University, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ersanli
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D011446:Prospective Studies; D012720:Severity of Illness Index; D016277:Ventricular Function, Left / Q000502:physiology*