title: Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy.
abstract: Photodynamic therapy (PDT) is a site-specific treatment of cancer using much lower optical power densities with minimal nonspecific damage to normal tissues. To improve the therapeutic efficiency of PDT, we fabricated a multifunctional theranostic nanoparticle system (DSSCe6@Fe3O4NPs) by loading Fe3O4nanoparticles in redox-responsive chlorin e6 (Ce6)-conjugated dextran nanoparticles for near-infrared (NIR)/magnetic resonance (MR) dual-modality imaging and magnetic targeting. The obtained DSSCe6@Fe3O4NPs demonstrated a uniform nanospherical morphology consisting of Fe3O4clusters. The fluorescence signal of Ce6 of this theranostic system could turn "ON" from a self-quenching state in a reductive intracellular environment. T2-Weighted MR imaging revealed a high transverse relaxivity (r2) measured to be 194.4 S-1mM-1, confirming that it was also a distinctive contrast agent in T2-weighted MR imaging. Confocal images and flow cytometry results showed that the cellular uptake of DSSCe6@Fe3O4NPs was enhanced effectively under an extra magnetic field, which resulted in promoted PDT therapeutic efficiency. In vivo MR imaging showed that DSSCe6@Fe3O4NPs effectively accumulated in tumors under an extra magnetic field. These results illustrated that the DSSCe6@Fe3O4NPs could be a promising theranostic system for both NIR/MR imaging-guided PDT precision therapy.
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn and Nano Science and Technology Institute, University of Science & Technology of China, Suzhou, 215123, P. R. China.
authors.forename: Zexuan
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn and Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge 117576, Singapore.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Dehong
authors.initials: D
authors.lastname: Hu
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Zonghai
authors.initials: Z
authors.lastname: Sheng
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Huqiang
authors.initials: H
authors.lastname: Yi
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Guanhui
authors.initials: G
authors.lastname: Gao
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Yayun
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Zhang
authors.affiliation: General Hospital of Chinese Armed Police Forces, Beijing 100039, P.R. China.
authors.forename: Shaozhi
authors.initials: S
authors.lastname: Ling
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Lintao
authors.identifier: http://orcid.org/0000-0002-2461-6390
authors.initials: L
authors.lastname: Cai
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002735:Chlorophyllides; D003911:Dextrans / Q000737:chemistry / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D052203:Ferrosoferric Oxide / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D007259:Infrared Rays; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging / Q000379:methods; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D061848:Optical Imaging / Q000379:methods; D010084:Oxidation-Reduction; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D011166:Porphyrins / Q000737:chemistry / Q000627:therapeutic use*; D000068936:Theranostic Nanomedicine / Q000379:methods
chemical_list: D002735:Chlorophyllides; D003911:Dextrans; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin; D052203:Ferrosoferric Oxide