title: Sex differences in transplantation.
abstract: Sex plays a role in the incidence and progression of a wide variety of diseases and conditions related to transplantation. Additionally, a growing body of clinical and experimental evidence suggests that sex can impact the pharmacokinetics and pharmacodynamics of several commonly used immunosuppressive and anti-infective drugs in transplant recipients. A better understanding of these sex differences will facilitate advances in individualizing treatment for patients and improve outcomes of solid organ transplantation. Here, we provide a review of sex-related differences in transplantation and highlight opportunities for future research directions.
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego/La Jolla, CA.
authors.forename: Jeremiah D
authors.initials: JD
authors.lastname: Momper
authors.affiliation: Kidney Transplant/Department of Pharmacy Services, UC San Diego Health System, University of California, San Diego/La Jolla, CA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Misel
authors.affiliation: Division of Nephrology-Hypertension, School of Medicine, University of California, San Diego/La Jolla, CA. Electronic address: d1mckay@ucsd.edu.
authors.forename: Dianne B
authors.initials: DB
authors.lastname: McKay
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D016377:Organ Transplantation; D012737:Sex Factors
chemical_list: D000890:Anti-Infective Agents; D007166:Immunosuppressive Agents