title: A New 1,5-Dihydroxy-4-methoxyisoquinoline from Scolopendra subspinipes mutilans.
abstract: A new isoquinoline, 1,5-dihydroxy-4-methoxyisoquinoline (1), was obtained from Scolopendra subspinipes mutilans. Compound 1 showed moderate cytotoxicity on tumour cells with IC50values ranging from 13 to 26 μm against five esophageal squamous cancer cells whereas low cytotoxicity against normal human esophageal epithelial cells. Isoquinoline ring oxidized at C(1), C(4), and C(5) can enhance its cytotoxicity. In addition, compound 1 showed potent inhibitory effect (inhibition rate > 50% at 13 μm) on cell migration in human umbilical vein endothelial cells. This article mainly studies the structure and activity of 1, and more modification of 1 as a potential anticancer agent.
authors.affiliation: The Engineering Research Centre of Peptide Drug Discovery and Development, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing, 210009, P. R. China.
authors.forename: Ya-Ru
authors.initials: YR
authors.lastname: Guo
authors.affiliation: The Engineering Research Centre of Peptide Drug Discovery and Development, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing, 210009, P. R. China.
authors.forename: Peng-Xiang
authors.initials: PX
authors.lastname: Wu
authors.affiliation: The Engineering Research Centre of Peptide Drug Discovery and Development, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing, 210009, P. R. China.|State Key Laboratory of Natural Medicines, Ministry of Education, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing, 210009, P. R. China.
authors.forename: Han-Mei
authors.initials: HM
authors.lastname: Xu
authors.affiliation: The Engineering Research Centre of Peptide Drug Discovery and Development, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing, 210009, P. R. China.
authors.forename: Wei-Yan
authors.initials: WY
authors.lastname: Qi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001181:Arthropods / Q000737:chemistry*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D000077277:Esophageal Squamous Cell Carcinoma; D006801:Humans; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C000621987:1,5-dihydroxy-4-methoxyisoquinoline; D000970:Antineoplastic Agents; D007546:Isoquinolines; C095653:1,5-dihydroxyisoquinoline; C039109:isoquinoline
keywords: 
  Scolopendra subspinipes mutilans
  ; Cancer; Cytotoxic activities; Isoquinoline alkaloid; Migration