title: Current Concepts of Cardiac Amyloidosis: Diagnosis, Clinical Management, and the Need for Collaboration.
abstract: Cardiac amyloidosis is a complex and vexing clinical condition that requires a high degree of suspicion for the diagnosis with a substantial amount of discipline to discern the extent of disease and the best available therapy. There is a complex interplay between multiple organ systems, and the clinical presentation may involve a myriad of confusing clinical symptoms. The diagnosis of cardiac amyloidosis can be confirmed with a combination of physical findings, cardiac biomarkers, noninvasive testing, and, if necessary, myocardial biopsy. Genetic testing is critical to establish the type of amyloidosis.
authors.affiliation: Department of Internal Medicine, Vanderbilt University School of Medicine, 1215 21st Avenue South, Suite 5209, Nashville, TN 37232, USA.
authors.forename: Alexandra J
authors.initials: AJ
authors.lastname: Ritts
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, Vanderbilt University School of Medicine, 1215 21st Avenue South, Suite 5209, Nashville, TN 37232, USA.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Cornell
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Vanderbilt University School of Medicine, 1215 21st Avenue South, Suite 5209, Nashville, TN 37232, USA.
authors.forename: Kris
authors.initials: K
authors.lastname: Swiger
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Vanderbilt University School of Medicine, 1215 21st Avenue South, Suite 5209, Nashville, TN 37232, USA.
authors.forename: Jai
authors.initials: J
authors.lastname: Singh
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, Vanderbilt University School of Medicine, 1215 21st Avenue South, Suite 5209, Nashville, TN 37232, USA.
authors.forename: Stacey
authors.initials: S
authors.lastname: Goodman
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Vanderbilt University Medical Center, 1215 21st Avenue South, Suite 5209, Nashville, TN 37232, USA. Electronic address: daniel.lenihan@vanderbilt.edu.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Lenihan
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D019468:Disease Management; D042241:Early Diagnosis; D006331:Heart Diseases / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D006801:Humans
keywords: Cardiac amyloidosis; Cardiotoxicity; Immunomodulatory drugs; Multiple myeloma; Proteasome inhibitors; TTR