title: Tumor volume as an independent predictive factor of worse survival in patients with oral cavity squamous cell carcinoma.
abstract: The purpose of the present study was to investigate the role of tumor volume in the prognosis of patients with oral cavity squamous cell carcinoma (SCC).
  
  
  
  One hundred twenty-three patients with T4a oral cavity SCCs underwent surgical treatment. The volumes of the primary cancer were calculated by the multiplication of 3 macroscopic dimensions of the surgical specimen and related to recurrence and death.
  
  
  
  There were 54 recurrences (43.9%) and 75 deaths (60.9%). The mean tumor volume among the patients living without disease during the follow-up period was 28.2 cc, compared to 88.2 cc for patients living with disease, and to 78.9 cc for patients who died of the disease (p < .001). Multivariate analyses showed that volume and perineural invasion were independent factors for recurrence, whereas volume and lymph node metastasis were independent factors for death.
  
  
  
  Among patients who already have advanced cancers, tumor volume can significantly impact their prognoses. © 2017 Wiley Periodicals, Inc. Head Neck 39: 960-964, 2017.
authors.affiliation: Department of Head and Neck Surgery of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Chin Shien
authors.initials: CS
authors.lastname: Lin
authors.affiliation: Department of Head and Neck Surgery of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: André Bandiera
authors.initials: AB
authors.lastname: de Oliveira Santos
authors.affiliation: Department of Head and Neck Surgery of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Evandro Lima E
authors.initials: EL
authors.lastname: Silva
authors.affiliation: Department of Head and Neck Surgery of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Leandro Luongo
authors.initials: LL
authors.lastname: de Matos
authors.affiliation: Department of Head and Neck Surgery of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Raquel Ajub
authors.initials: RA
authors.lastname: Moyses
authors.affiliation: Department of Head and Neck Surgery of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Marco Aurélio Vamondes
authors.initials: MA
authors.lastname: Kulcsar
authors.affiliation: Department of Head and Neck Surgery of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Fábio Roberto
authors.initials: FR
authors.lastname: Pinto
authors.affiliation: Department of Head and Neck Surgery of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Lenine Garcia
authors.initials: LG
authors.lastname: Brandão
authors.affiliation: Department of Head and Neck Surgery of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Claudio Roberto
authors.initials: CR
authors.lastname: Cernea
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D012307:Risk Factors; D015996:Survival Rate; D047368:Tumor Burden
keywords: carcinoma; mouth neoplasms; prognosis; squamous cell carcinoma; tumor burden