title: QF-PCR in invasive prenatal diagnosis: a single-center experience in Turkey.
abstract: QF-PCR has been used for more than 20 years. It is based on investigation of polymorphic short tandem repeats (STRs) and is widely used for prenatal rapid aneuploidy detection.
  
  
  
  We report retrospectively our prenatal diagnosis results between January 2012 and May 2014 in Tepecik Training and Research Hospital Genetic Diagnostic Center. Prenatal diagnosis was recommended in 6800 high-risk pregnancies and 2883 patients agreed to invasive diagnosis. Chromosome analysis and QF-PCR were performed in all patients.
  
  
  
  Normal results were reported in 2711 cases by fetal karyotyping and in 2706 cases by QF-PCR. Anomaly detection rates were similar for the two methods (5.09% for karyotyping and 4.02% for QF-PCR).
  
  
  
  QF-PCR is a fast and reliable prenatal diagnosis method in all indication groups and may be preferred as the sole prenatal investigation in patients without fetal ultrasonographic findings.
authors.affiliation: Genetic Diagnostic Center, Tepecik Training and Research Hospital, İzmir, Turkey.
authors.forename: Özge
authors.initials: Ö
authors.lastname: Özer Kaya
authors.affiliation: Genetic Diagnostic Center, Tepecik Training and Research Hospital, İzmir, Turkey.
authors.forename: Altuğ
authors.initials: A
authors.lastname: Koç
authors.affiliation: Genetic Diagnostic Center, Tepecik Training and Research Hospital, İzmir, Turkey.
authors.forename: Taha Reşid
authors.initials: TR
authors.lastname: Özdemir
authors.affiliation: Genetic Diagnostic Center, Tepecik Training and Research Hospital, İzmir, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Kirbiyik
authors.affiliation: Genetic Diagnostic Center, Tepecik Training and Research Hospital, İzmir, Turkey.
authors.forename: Berk
authors.initials: B
authors.lastname: Özyilmaz
authors.affiliation: Department of Obstetrics and Gynecology, Tepecik Training and Research Hospital, İzmir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Özeren
authors.affiliation: Department of Obstetrics and Gynecology, Tepecik Training and Research Hospital, İzmir, Turkey.
authors.forename: Deniz Can
authors.initials: DC
authors.lastname: Öztekin
authors.affiliation: Department of Obstetrics and Gynecology, Tepecik Training and Research Hospital, İzmir, Turkey.
authors.forename: Cüneyt Eftal
authors.initials: CE
authors.lastname: Taner
authors.affiliation: Genetic Diagnostic Center, Tepecik Training and Research Hospital, İzmir, Turkey.
authors.forename: Yaşar Bekir
authors.initials: YB
authors.lastname: Kutbay
mesh_terms: D000649:Amniocentesis; D000782:Aneuploidy; D002869:Chromosome Aberrations; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007621:Karyotyping; D016133:Polymerase Chain Reaction / Q000379:methods*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D014421:Turkey