title: Fully integrated optical coherence tomography, ultrasound, and indocyanine green-based fluorescence tri-modality system for intravascular imaging.
abstract: We present a tri-modality imaging system and fully integrated tri-modality probe for intravascular imaging. The tri-modality imaging system is able to simultaneously acquire optical coherence tomography (OCT), ultrasound (US), and fluorescence imaging. Moreover, for fluorescence imaging, we used the FDA-approved indocyanine green (ICG) dye as the contrast agent to target lipid-loaded macrophages. We conducted imaging from a male New Zealand white rabbit to evaluate the performance of the tri-modality system. In addition, tri-modality images of rabbit aortas were correlated with hematoxylin and eosin (H&E) histology to check the measurement accuracy. The fully integrated miniature tri-modality probe, together with the use of ICG dye suggest that the system is of great potential for providing a more accurate assessment of vulnerable plaques in clinical applications.
authors.affiliation: Department of Biomedical Engineering and Beckman laser institute, University of California, Irvine, Irvine, CA 92617, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Biomedical Engineering and Beckman laser institute, University of California, Irvine, Irvine, CA 92617, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Jing
authors.affiliation: Department of Biomedical Engineering and Beckman laser institute, University of California, Irvine, Irvine, CA 92617, USA.
authors.forename: Yueqiao
authors.initials: Y
authors.lastname: Qu
authors.affiliation: Department of Biomedical Engineering and Beckman laser institute, University of California, Irvine, Irvine, CA 92617, USA.
authors.forename: Yusi
authors.initials: Y
authors.lastname: Miao
authors.affiliation: Department of Biomedical Engineering and Beckman laser institute, University of California, Irvine, Irvine, CA 92617, USA.
authors.forename: Buyun
authors.initials: B
authors.lastname: Zhang
authors.affiliation: The Resource Center for Medical Ultrasonic Transducer Technology, University of Southern California, Los Angeles 90089, USA.
authors.forename: Teng
authors.initials: T
authors.lastname: Ma
authors.affiliation: The Resource Center for Medical Ultrasonic Transducer Technology, University of Southern California, Los Angeles 90089, USA.
authors.forename: Mingyue
authors.initials: M
authors.lastname: Yu
authors.affiliation: The Resource Center for Medical Ultrasonic Transducer Technology, University of Southern California, Los Angeles 90089, USA.
authors.forename: Qifa
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Biomedical Engineering and Beckman laser institute, University of California, Irvine, Irvine, CA 92617, USA; Department of Biomedical Engineering, University of California, 5200 Engineering Hall, Irvine, California 92697, USA.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
keywords: (110.4190) Multiple imaging; (110.4500) Optical coherence tomography; (110.7170) Ultrasound; (170.0170) Medical optics and biotechnology; (170.2150) Endoscopic imaging; (260.2510) Fluorescence