title: Primary Burkitt lymphoma of the supraglottic larynx: a case report and review of the literature.
abstract: BACKGROUND
  Burkitt lymphoma is a high-grade B cell lymphoma which accounts for less than 1% of all adult cases of non-Hodgkin lymphoma. Rare instances of Burkitt lymphoma developing secondary to prior irradiation have been described in the literature.
  
  
  METHODS
  We report a case of a 90-year-old white woman with a recent history of irradiation for Hodgkin lymphoma, who presented with primary Burkitt lymphoma of the supraglottic larynx. She underwent emergency awake tracheostomy with biopsy. A histopathological examination confirmed non-Hodgkin, B cell lymphoma of Burkitt type. Given her age and poor functional status, she underwent treatment with palliative radiotherapy.
  
  
  CONCLUSIONS
  A literature review was performed to clarify the clinical characteristics of radiation-induced Burkitt lymphoma in the head and neck, as well as its diagnosis and management. The present case represents the second case of radiation-induced Burkitt lymphoma in the head and neck in the reported literature, and the first in the supraglottic larynx. It highlights the need to maintain a broad differential in the assessment of malignancies of the larynx, particularly in patients with a prior history of radiation treatment.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Ottawa, 501 Smyth Rd, Ottawa, ON, K1H 8L6, Canada. aquim047@uottawa.ca.
authors.forename: Alexandra E
authors.initials: AE
authors.lastname: Quimby
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Ottawa, 501 Smyth Rd, Ottawa, ON, K1H 8L6, Canada.
authors.forename: Lisa
authors.initials: L
authors.lastname: Caulley
authors.affiliation: Department of Radiation Oncology, University of Toronto, 150 College Street, FitzGerald Building, Rm 106, Toronto, ON, M5S 3E2, Canada.
authors.forename: Danielle
authors.initials: D
authors.lastname: Rodin
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Ottawa, 451 Smyth Rd, Rm 4155, Ottawa, ON, K1H 8M5, Canada.
authors.forename: Bibianna
authors.initials: B
authors.lastname: Purgina
authors.affiliation: Department of Radiation Oncology, University of Ottawa, 501 Smyth Rd, Ottawa, ON, K1H 8L6, Canada.
authors.forename: Libni
authors.initials: L
authors.lastname: Eapen
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Ottawa, 451 Smyth Rd, Rm 4155, Ottawa, ON, K1H 8M5, Canada.
authors.forename: Luke
authors.initials: L
authors.lastname: Shier
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Ottawa, 501 Smyth Rd, Ottawa, ON, K1H 8L6, Canada.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Johnson-Obaseki
mesh_terms: D000369:Aged, 80 and over; D002051:Burkitt Lymphoma / Q000473:pathology* / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D007830:Larynx / Q000473:pathology*; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed
keywords: Burkitt; Case report; Irradiation; Larynx; Lymphoma; Supraglottis