title: Elevated Plasma Homocysteine Level Increased the Risk of Early Renal Impairment in Acute Ischemic Stroke Patients.
abstract: Renal insufficiency is associated with the prognosis of acute ischemic stroke (AIS) and homocysteine (Hcy) levels. This study investigated the association between plasma Hcy levels and renal insufficiency in patients with AIS. A total of 987 patients with AIS who had been treated at the First People's Hospital of Foshan between 2011 and 2014 were retrospectively studied. Based on their cystatin C (Cys C) levels, the patients were divided into the normal renal function group (Cys C ≤ 1.25 mg/L) or the renal impairment group (Cys C > 1.25 mg/L). Multivariate regression analysis was applied to reveal the association between hyperhomocysteinemia (HHcy) and renal impairment. The renal impairment group showed more advanced age of onset, higher percentage of prior stroke and hypertension, higher baseline National Institute of Health Stroke Scale score, lower high-density lipoprotein cholesterol levels, and higher Hcy levels compared with the normal renal function group. A multivariate analysis revealed a relationship between early renal impairment and Hcy levels: an increase of Hcy by 1 μmol/L was associated with an increase of 12-18% of the risk of renal impairment among patients with AIS and HHcy. Patients with AIS and HHcy had a 2.42-3.51 fold increase of the risk of renal impairment compared with patients with normal Hcy level (P < 0.001). In conclusion, patients with stroke and HHcy could be more prone to renal impairment.
authors.affiliation: First People's Hospital of Foshan, Foshan, 528000, China.
authors.forename: Jingjuan
authors.initials: J
authors.lastname: Chen
authors.affiliation: First People's Hospital of Foshan, Foshan, 528000, China.
authors.forename: Guode
authors.initials: G
authors.lastname: Li
authors.affiliation: First People's Hospital of Foshan, Foshan, 528000, China.
authors.forename: Zuohang
authors.initials: Z
authors.lastname: Xu
authors.affiliation: First People's Hospital of Foshan, Foshan, 528000, China. zcguo@fsyyy.com.
authors.forename: Chengguo
authors.initials: C
authors.lastname: Zhang
authors.affiliation: First People's Hospital of Foshan, Foshan, 528000, China.
authors.forename: Yukai
authors.initials: Y
authors.lastname: Wang
authors.affiliation: First People's Hospital of Foshan, Foshan, 528000, China.
authors.forename: Haiqun
authors.initials: H
authors.lastname: Xie
authors.affiliation: First People's Hospital of Foshan, Foshan, 528000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shao
authors.affiliation: First People's Hospital of Foshan, Foshan, 528000, China.
authors.forename: Lingmei
authors.initials: L
authors.lastname: Peng
authors.affiliation: First People's Hospital of Foshan, Foshan, 528000, China.
authors.forename: Jiancong
authors.initials: J
authors.lastname: Lu
authors.affiliation: First People's Hospital of Foshan, Foshan, 528000, China.
authors.forename: Dahua
authors.initials: D
authors.lastname: Yuan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000175:diagnosis; D007674:Kidney Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D006710:Homocysteine
keywords: Cystatin C; Glomerular filtration rate; Homocysteine; Renal insufficiency; Stroke