title: Application of a new robust ECG T-wave delineation algorithm for the evaluation of the autonomic innervation of the myocardium.
abstract: T-wave amplitude (TWA) is a well know index of the autonomic innervation of the myocardium. However, until now it has been evaluated only manually or with simple and inefficient algorithms. In this paper, we developed a new robust single-lead electrocardiogram (ECG) T-wave delineation algorithm that is able to detect the T-wave with a wavelet based method and automatically calculate the TWA. We evaluated the algorithm on the QT database, achieving a sensitivity of 99.92% for the T wave peak and 99.38% for the T wave end. In addition, the percentage of records automatically delineated with high precision was higher than previous published works. Finally, the algorithm was applied to study the influence of anticholinergic and antiadrenergic drugs (i.e. atropine and metoprolol) on the TWA. It was observed that atropine significantly decreased the TWA when compared to baseline level, that head-up tilt caused a decrease of TWA and that metoprolol blunted this decrease. Through the development of a robust algorithm, this study opens the way for further research on the T-wave analysis for the assessment of the autonomic innervation of the ventricular myocardium.
authors.forename: Matteo
authors.initials: M
authors.lastname: Cesari
authors.forename: Jesper
authors.initials: J
authors.lastname: Mehlsen
authors.forename: Anne-Birgitte
authors.initials: AB
authors.lastname: Mehlsen
authors.forename: Helge Bjarup
authors.initials: HB
authors.lastname: Dissing Sorensen
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000494:pharmacology; D000328:Adult; D000465:Algorithms; D001285:Atropine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000502:physiology; D016208:Databases, Factual; D004562:Electrocardiography / Q000379:methods*; D006321:Heart / Q000187:drug effects; D006329:Heart Conduction System; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D009206:Myocardium; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D058067:Wavelet Analysis
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D001285:Atropine; D008790:Metoprolol