title: Decarboxylative Fluorination of Electron-Rich Heteroaromatic Carboxylic Acids with Selectfluor.
abstract: A transition-metal-free decarboxylative fluorination of electron-rich five-membered heteroaromatics, including furan-, pyrazole-, isoxazole-, thiophene-, indole-, benzofuran- and indazolecarboxylic acids, with Selectfluor is reported. Fluorinated dimer products were observed for nitrogen-containing heteroaromatic carboxylic acids, such as indole and pyrazole. An effective method has been developed to synthesize the monomer of 2- and 3-fluoroindoles with Li2CO3as base at low temperature.
authors.affiliation: Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University , Changsha 410083, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University , Changsha 410083, China.
authors.forename: Jian-Fei
authors.initials: JF
authors.lastname: Yao
authors.affiliation: Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University , Changsha 410083, China.
authors.forename: Zhen-Yu
authors.identifier: 0000-0002-3972-5047
authors.initials: ZY
authors.lastname: Tang