title: Neural Circuit Mechanisms Underlying Emotional Regulation of Homeostatic Feeding.
abstract: The neural circuits controlling feeding and emotional behaviors are intricately and reciprocally connected. Recent technological developments, including cell type-specific optogenetic and chemogenetic approaches, allow functional characterization of genetically defined cell populations and neural circuits in feeding and emotional processes. Here we review recent studies that have utilized circuit-based manipulations to decipher the functional interactions between neural circuits controlling feeding and those controlling emotional processes. Specifically, we highlight newly described neural circuit interactions between classical emotion-related brain regions, such as the hippocampus and amygdala, and homeostatic feeding circuitry in the arcuate nucleus and lateral hypothalamus (LH). Together these circuits will provide a template for future studies to examine functional interactions between feeding and emotion.
authors.affiliation: Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: Sweeney
authors.affiliation: Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA. Electronic address: yangyun@upstate.edu.
authors.forename: Yunlei
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism / Q000502:physiology; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D004644:Emotions / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology / Q000523:psychology; D006801:Humans; D007026:Hypothalamic Area, Lateral / Q000378:metabolism / Q000502:physiology