title: The mammalian target of rapamycin inhibitor everolimus suppresses proliferation, metabolic activity and collagen synthesis of human fibroblasts in vitro and exerts antifibrogenic effects in vivo.
authors.affiliation: Department of Dermatology, University of Münster, Von-Esmarch-Straße 58, 48149, Münster, Germany.
authors.forename: M
authors.identifier: 0000-0001-7338-7734
authors.initials: M
authors.lastname: Böhm
authors.affiliation: Department of Dermatology, University of Münster, Von-Esmarch-Straße 58, 48149, Münster, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Stegemann
authors.affiliation: Department of Dermatology, University of Münster, Von-Esmarch-Straße 58, 48149, Münster, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Metze
authors.affiliation: Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Scharffetter-Kochanek
authors.affiliation: Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Sindrilaru
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000633:toxicity; D049109:Cell Proliferation / Q000187:drug effects; D003094:Collagen / Q000096:biosynthesis*; D024042:Collagen Type I / Q000378:metabolism; D000090602:Collagen Type I, alpha 1 Chain; D024061:Collagen Type III / Q000378:metabolism; D004338:Drug Combinations; D000068338:Everolimus / Q000494:pharmacology*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects
chemical_list: C000601279:COL1A2 protein, human; C439971:COL3A1 protein, human; D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D024061:Collagen Type III; D004338:Drug Combinations; D007166:Immunosuppressive Agents; D012333:RNA, Messenger; D016222:Fibroblast Growth Factor 2; D001761:Bleomycin; D003094:Collagen; D000068338:Everolimus