title: Influence of microRNAs and Long Non-Coding RNAs in Cancer Chemoresistance.
abstract: Innate and acquired chemoresistance exhibited by most tumours exposed to conventional chemotherapeutic agents account for the majority of relapse cases in cancer patients. Such chemoresistance phenotypes are of a multi-factorial nature from multiple key molecular players. The discovery of the RNA interference pathway in 1998 and the widespread gene regulatory influences exerted by microRNAs (miRNAs) and other non-coding RNAs have certainly expanded the level of intricacy present for the development of any single physiological phenotype, including cancer chemoresistance. This review article focuses on the latest research efforts in identifying and validating specific key molecular players from the two main families of non-coding RNAs, namely miRNAs and long non-coding RNAs (lncRNAs), having direct or indirect influences in the development of cancer drug resistance properties and how such knowledge can be utilised for novel theranostics in oncology.
authors.affiliation: Centre for Molecular Medicine and Biobanking, University of Malta, Msida MSD2080, Malta. Duncan.Ayers@um.edu.mt.|Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M1 7DN, UK. Duncan.Ayers@um.edu.mt.
authors.forename: Duncan
authors.initials: D
authors.lastname: Ayers
authors.affiliation: Center for Medical Genetics Ghent, Ghent University, Ghent 9000, Belgium. Joke.Vandesompele@UGent.be.|Cancer Research Institute Ghent (CRIG), Ghent University, Ghent 9000, Belgium. Joke.Vandesompele@UGent.be.
authors.forename: Jo
authors.initials: J
authors.lastname: Vandesompele
keywords: cancer; chemoresistance; drug resistance; lncRNA; miRNA; microRNA; tumour