title: A miniature closed-loop deep brain stimulation device.
abstract: This paper presents a miniature light-weight closed-loop deep brain stimulation (DBS) device that delivers on-demand stimulation current pulses by monitoring and analysing local field potentials. The device includes monitoring and DBS units, each designed and fabricated on a separate small round circuit board. The closed-loop DBS device has been successfully validated by injecting a pre-recorded neural signal into its input, and collecting and analysing its output. The monitoring unit has an amplification gain of 113 dB in frequency range of 0.7-50 Hz. The DBS unit gives on-demand stimulation current pulses of duration 90 μs, frequency 130 Hz, and amplitude 200 μA. The total weight of the device including a 3V coin battery is 1.41 g. The diameter of the device is 11.4 mm. This portable head-mountable device is suitable for use in pre-clinical trials with small laboratory animals.
authors.forename: Mahboubeh
authors.initials: M
authors.lastname: Parastarfeizabadi
authors.forename: Abbas Z
authors.initials: AZ
authors.lastname: Kouzani
authors.forename: Ian
authors.initials: I
authors.lastname: Gibson
authors.forename: Susannah J
authors.initials: SJ
authors.lastname: Tye
mesh_terms: D000818:Animals; D046690:Deep Brain Stimulation; D004864:Equipment and Supplies