title: Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies.
abstract: Pentacyclic triterpenes are naturally found in a great variety of fruits, vegetables and medicinal plants and are therefore part of the human diet. The beneficial health effects of edible and medicinal plants have partly been associated with their triterpene content, but the in vivo efficacy in humans depends on many factors, including absorption and metabolism. This review presents an overview of in vitro and in vivo studies that were carried out to determine the bioavailability of pentacyclic triterpenes and highlights the efforts that have been performed to improve the dissolution properties and absorption of these compounds. As plant matrices play a critical role in triterpene bioaccessibility, this review covers literature data on the bioavailability of pentacyclic triterpenes ingested either from foods and medicinal plants or in their free form.
authors.affiliation: Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café, s/n, Ribeirão Preto, São Paulo 14040903, Brazil. niege@fcfrp.usp.br.
authors.forename: Niege A
authors.initials: NA
authors.lastname: J C Furtado
authors.affiliation: Institut des Sciences de la Vie, Université Catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium. pirson.laetitia@gmail.com.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Pirson
authors.affiliation: Institut des Sciences de la Vie, Université Catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium. edelberg@gmail.com.
authors.forename: Hélène
authors.initials: H
authors.lastname: Edelberg
authors.affiliation: Institut des Sciences de la Vie, Université Catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium. mirandamirandalisa@yahoo.fr.
authors.forename: Lisa
authors.initials: L
authors.lastname: M Miranda
authors.affiliation: Louvain Drug Research Institute, Université Catholique de Louvain, B-1200 Brussels, Belgium. cristina.loira@uclouvain.be.
authors.forename: Cristina
authors.initials: C
authors.lastname: Loira-Pastoriza
authors.affiliation: Louvain Drug Research Institute, Université Catholique de Louvain, B-1200 Brussels, Belgium. veronique.preat@uclouvain.be.
authors.forename: Véronique
authors.initials: V
authors.lastname: Preat
authors.affiliation: Institut des Sciences de la Vie, Université Catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium. yvan.larondelle@uclouvain.be.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Larondelle
authors.affiliation: Department of Environmental Research and Innovation, Luxembourg Institute of Science and Technology, L-4422 Belvaux, Luxembourg. christelle.andre@list.lu.
authors.forename: Christelle M
authors.initials: CM
authors.lastname: André
mesh_terms: D000818:Animals; D001682:Biological Availability; D005504:Food Analysis; D006801:Humans; D066298:In Vitro Techniques; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes / Q000493:pharmacokinetics*; D010936:Plant Extracts / Q000493:pharmacokinetics; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D053978:Pentacyclic Triterpenes; D010936:Plant Extracts
keywords: bioavailability; in vitro studies; in vivo studies; pentacyclic triterpenes