title: Anti-complementary constituents of Viola kunawarensis.
abstract: Activity-guided fractionation for complement inhibitors led to the isolation of 22 known compounds from Viola kunawarensis. Chemical types include six sterol compounds, three coumarin compounds, five megastigmane compounds, two triterpenoid compounds, two phenylpropanoid compounds, one chlorophyll, one amide, and two lipid compounds. Among which, two sterols (stigmasta-4-ene-3β,6β-diol and saringosterone), one amide (aurantiamide acetate) and a norsesquiterpenoid (solalyratin B) exhibited better anti-complementary effects with CH50values ranging from 0.02 to 0.08 mM, which are plausible candidates for developing potent anti-complementary agents.
authors.affiliation: a Key Laboratory of Xinjiang Endemic Phytomedicine Resources Ministry of Education , Shihezi University College of Pharmacy , Shihezi , P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Xinjiang Endemic Phytomedicine Resources Ministry of Education , Shihezi University College of Pharmacy , Shihezi , P.R. China.
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Cong
authors.affiliation: b Department of Pharmacognosy, School of Pharmacy , Fudan University , Shanghai , P.R. China.
authors.forename: Ze-Long
authors.initials: ZL
authors.lastname: Fu
authors.affiliation: b Department of Pharmacognosy, School of Pharmacy , Fudan University , Shanghai , P.R. China.
authors.forename: Dao-Feng
authors.initials: DF
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Xinjiang Endemic Phytomedicine Resources Ministry of Education , Shihezi University College of Pharmacy , Shihezi , P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
mesh_terms: D005591:Chemical Fractionation; D051056:Complement Inactivating Agents / Q000302:isolation & purification*; D003374:Coumarins / Q000302:isolation & purification; D006027:Glycosides / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000737:chemistry; D013150:Spirostans / Q000302:isolation & purification; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification; D013265:Stigmasterol / Q000031:analogs & derivatives / Q000302:isolation & purification; D014315:Triterpenes / Q000302:isolation & purification; D032413:Viola / Q000737:chemistry*
chemical_list: D051056:Complement Inactivating Agents; D003374:Coumarins; D006027:Glycosides; D010936:Plant Extracts; D013150:Spirostans; D013261:Sterols; D014315:Triterpenes; C478022:saringosterone; C108599:solalyratine B; D013265:Stigmasterol
keywords: Viola kunawarensis; Violaceae; anti-complementary activity; chemical constituents