title: Mechanisms of Non-canonical Activation of Ataxia Telangiectasia Mutated.
abstract: ATM is a master regulator of the cellular response to DNA damage. The classical mechanism of ATM activation involves its monomerization in response to DNA double-strand breaks, resulting in ATM-dependent phosphorylation of more than a thousand substrates required for cell cycle progression, DNA repair, and apoptosis. Here, new experimental evidence for non-canonical mechanisms of ATM activation in response to stimuli distinct from DNA double-strand breaks is discussed. It includes cytoskeletal changes, chromatin modifications, RNA-DNA hybrids, and DNA single-strand breaks. Noncanonical ATM activation may be important for the pathology of the multisystemic disease Ataxia Telangiectasia.
authors.affiliation: University of Cambridge, Department of Biochemistry, Cambridge, CB2 1GA, UK. sk870@cam.ac.uk.
authors.forename: S V
authors.initials: SV
authors.lastname: Khoronenkova
mesh_terms: D000818:Animals; D001260:Ataxia Telangiectasia / Q000235:genetics / Q000503:physiopathology; D064007:Ataxia Telangiectasia Mutated Proteins / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D004260:DNA Repair; D004277:DNA, Single-Stranded / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D012313:RNA / Q000378:metabolism
chemical_list: D004277:DNA, Single-Stranded; D012313:RNA; D004247:DNA; D064007:Ataxia Telangiectasia Mutated Proteins