title: Fluoride or/and aluminum induced toxicity in guinea pig teeth with the low expression of dentine phosphoprotein.
abstract: This study investigated the damage and expression of dentine phosphoprotein (DPP) in guinea pig teeth by the administration of fluoride (F) or/and aluminum (Al). Fifty-two guinea pigs were divided randomly into four groups (control, F, Al, and F+Al). F (150 mg NaF/L) or/and Al (300 mg AlCl3/L) were added in their drinking water for 90 days. The levels of F ion, dentine sialophosphoprotein (DSPP) gene, and DPP protein in incisor and molar were determined, respectively. The results showed that the concentrations of F ion in F and F+Al groups were increased significantly. F induced the mottled enamel and irregular abrasion of teeth, which might occur as a consequence of depressed DSPP mRNA and DPP protein expression. Both the gene and protein expressions showed obvious decrease induced by Al, especially by F. There were no synergistic effects between F and Al, instead, Al inhibited the toxicity of F.
authors.affiliation: Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.|Chifeng Academy of Agriculture and Animal Husbandry Sciences, Chifeng, Inner Mongolia, 024031, People's Republic of China.|Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin, 130062, People's Republic of China.
authors.forename: Tianlong
authors.initials: T
authors.lastname: Han
authors.affiliation: Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.|Chifeng Academy of Agriculture and Animal Husbandry Sciences, Chifeng, Inner Mongolia, 024031, People's Republic of China.|Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin, 130062, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Cao
authors.affiliation: Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.
authors.forename: Huacheng
authors.initials: H
authors.lastname: Chen
authors.affiliation: Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.|Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin, 130062, People's Republic of China.
authors.forename: Guanghe
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Chifeng Academy of Agriculture and Animal Husbandry Sciences, Chifeng, Inner Mongolia, 024031, People's Republic of China.
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.affiliation: Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.
authors.forename: Jundong
authors.initials: J
authors.lastname: Wang
mesh_terms: D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D003743:Dental Enamel / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis*; D005459:Fluorides / Q000633:toxicity*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006168:Guinea Pigs; D010750:Phosphoproteins / Q000096:biosynthesis*; D012795:Sialoglycoproteins / Q000096:biosynthesis*; D000099311:Dentin Sialophosphoprotein
chemical_list: D000535:Aluminum; D016326:Extracellular Matrix Proteins; D005459:Fluorides; D010750:Phosphoproteins; D012795:Sialoglycoproteins; D000099311:Dentin Sialophosphoprotein
keywords: aluminum; dentine phosphoprotein; fluoride; guinea pig; teeth