title: Role of stereotactic body radiation therapy for lung metastases from radio-resistant primary tumours.
abstract: OBJECTIVE
  A retrospective analysis was performed on patients treated for lung oligo-metastatic disease from radio-resistant histology groups.
  
  
  METHODS
  The primary end point was local control (LC), secondary end points were overall survival (OS) and progression free survival (PFS). Toxicity was scored according to CTCAE 4.03.
  
  
  RESULTS
  200 patients were analyzed: 49.5% of the cases derived from colorectal primary tumors, 20.5% from sarcomas, 12.0% from renal cell carcinoma and the rest from other mixed origin. The mean follow-up was 24.2 months. LC at 1 and 2 years was 91, 84.9%. Primary histology and the presence of extra-pulmonary disease had a significant impact on LC. OS at 1 and 2 years was 88.7, 65.4%. Primary histology, disease free interval, presence of extra-pulmonary disease, number of irradiated lung lesions and age showed a correlation with prognosis at univariate analysis. PFS at 1 and 2 years was 84, 57.7%. The presence of extra-pulmonary disease and the number of irradiated lung lesions correlated with prognosis. Treatment was well tolerated with no G3-4 acute or late toxicity recorded.
  
  
  CONCLUSIONS
  Colorectal metastases showed a higher rate of local relapse. However, the factors mostly influencing prognosis were the presence of extra-pulmonary disease and the number of lung lesions.
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy. davide.franceschini@humanitas.it.
authors.forename: Davide
authors.initials: D
authors.lastname: Franceschini
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.|Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Cozzi
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
authors.forename: Fiorenza
authors.initials: F
authors.lastname: De Rose
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
authors.forename: Piera
authors.initials: P
authors.lastname: Navarria
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
authors.forename: Ciro
authors.initials: C
authors.lastname: Franzese
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Comito
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Iftode
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Tozzi
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Di Brina
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Ascolese
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Clerici
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: D'Agostino
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Fogliata
authors.affiliation: Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.|Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Scorsetti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000532:radiotherapy*; D011836:Radiation Tolerance; D016634:Radiosurgery; D012189:Retrospective Studies; D055815:Young Adult
keywords: Lung; Radio-resistant histology; SBRT