title: Metabolic engineering for the microbial production of marine bioactive compounds.
abstract: Many marine bioactive compounds have medicinal and nutritional values. These bioactive compounds have been prepared using solvent-based extraction from marine bio-resources or chemical synthesis, which are costly, inefficient with low yields, and environmentally unfriendly. Recent advances in metabolic engineering allowed to some extent more efficient production of these compounds, showing promises to meet the increasing demand of marine natural bioactive compounds. In this paper, we review the strategies and statuses of metabolic engineering applied to microbial production of marine natural bioactive compounds including terpenoids and their derivatives, omega-3 polyunsaturated fatty acids, and marine natural drugs, and provide perspectives.
authors.affiliation: Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, Daejeon, Republic of Korea; College of Food Science and Engineering, Ocean University of China, Qingdao, People's Republic of China. Electronic address: xzhmao@ouc.edu.cn.
authors.forename: Xiangzhao
authors.initials: X
authors.lastname: Mao
authors.affiliation: College of Food Science and Engineering, Ocean University of China, Qingdao, People's Republic of China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: College of Food Science and Engineering, Ocean University of China, Qingdao, People's Republic of China.
authors.forename: Jianan
authors.initials: J
authors.lastname: Sun
authors.affiliation: Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, Daejeon, Republic of Korea. Electronic address: leesy@kaist.ac.kr.
authors.forename: Sang Yup
authors.initials: SY
authors.lastname: Lee
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000378:metabolism*; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D005399:Fishes / Q000378:metabolism; D060847:Metabolic Engineering; D058086:Microalgae / Q000378:metabolism; D011161:Porifera / Q000378:metabolism; D013185:Squalene / Q000378:metabolism*; D013729:Terpenes / Q000378:metabolism*; D024341:Xanthophylls / Q000378:metabolism
chemical_list: D015525:Fatty Acids, Omega-3; D013729:Terpenes; D024341:Xanthophylls; D013185:Squalene; C005948:astaxanthine
keywords: Astaxanthin; Docosahexaenoic acid; Eicosapentaenoic acid; Marine bioactive compounds; Marine natural drugs; Metabolic engineering; Omega-3 polyunsaturated fatty acids; Squalene; Terpenoids