title: Controlling self-assembly of diphenylalanine peptides at high pH using heterocyclic capping groups.
abstract: Using small angle neutron scattering (SANS), it is shown that the existence of pre-assembled structures at high pH for a capped diphenylalanine hydrogel is controlled by the selection of N-terminal heterocyclic capping group, namely indole or carbazole. At high pH, changing from a somewhat hydrophilic indole capping group to a more hydrophobic carbazole capping group results in a shift from a high proportion of monomers to self-assembled fibers or wormlike micelles. The presence of these different self-assembled structures at high pH is confirmed through NMR and circular dichroism spectroscopy, scanning probe microscopy and cryogenic transmission electron microscopy.
authors.affiliation: School of Chemistry, The Australian Centre for Nanomedicine and the ARC Centre for Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, NSW, 2052, Australia.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Martin
authors.affiliation: School of Chemistry, The Australian Centre for Nanomedicine and the ARC Centre for Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, NSW, 2052, Australia.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Wojciechowski
authors.affiliation: School of Chemistry, The Australian Centre for Nanomedicine and the ARC Centre for Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, NSW, 2052, Australia.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Robinson
authors.affiliation: School of Chemistry, The Australian Centre for Nanomedicine and the ARC Centre for Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, NSW, 2052, Australia.|Biomedical Imaging Facility (BMIF), Mark Wainwright Analytical Centre, University of New South Wales, Sydney NSW, 2052, Australia.
authors.forename: Celine
authors.initials: C
authors.lastname: Heu
authors.affiliation: Australian Nuclear Science and Technology Organisation, New Illawarra Rd, Lucas Heights, NSW, 2231, Australia.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Garvey
authors.affiliation: CSIRO Manufacturing, Bayview Ave, Clayton, Victoria 3168, Australia.
authors.forename: Julian
authors.initials: J
authors.lastname: Ratcliffe
authors.affiliation: CSIRO Manufacturing, Bayview Ave, Clayton, Victoria 3168, Australia.
authors.forename: Lynne J
authors.initials: LJ
authors.lastname: Waddington
authors.affiliation: CSIRO Manufacturing, Bayview Ave, Clayton, Victoria 3168, Australia.
authors.forename: James
authors.initials: J
authors.lastname: Gardiner
authors.affiliation: School of Chemistry, The Australian Centre for Nanomedicine and the ARC Centre for Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, NSW, 2052, Australia.
authors.forename: Pall
authors.initials: P
authors.lastname: Thordarson
mesh_terms: D002942:Circular Dichroism; D020285:Cryoelectron Microscopy; D004151:Dipeptides; D020100:Hydrogels / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D018625:Microscopy, Atomic Force; D033363:Neutron Diffraction; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry; D053838:Scattering, Small Angle
chemical_list: D004151:Dipeptides; D020100:Hydrogels; C026650:phenylalanylphenylalanine; D010649:Phenylalanine