title: The effect of carnosine on methylglyoxal-induced oxidative stress in rats.
abstract: Methylglyoxal (MG) is generated from glycolytic metabolites, lipid peroxidation, glucose autooxidation and protein glycation. It is a prooxidant inducing oxidative stress and formation of advanced glycation end products (AGE). Effect of carnosine (CAR) as an antioxidant on toxicity due to MG has generated interest. In this study, rats were given incrementally increased doses (100-300 mg/kg) of MG in drinking water for ten weeks. CAR (250 mg/kg i.p.) was administered with MG. Plasma thiobarbituric reactive substances (TBARS), protein carbonyl (PC), advanced oxidation protein products (AOPP) and AGE levels were elevated by MG, and CAR decreased PC, AOPP and AGE levels. MG increased liver reactive oxygen species (ROS), TBARS, PC and AOPP levels, which were decreased by CAR. Thus, in vivo role of CAR on chronic MG administration was observed to suppress the generated hepatic and plasma oxidative stress.
authors.affiliation: a Department of Biochemistry , Istanbul Medical Faculty, Istanbul University , Istanbul , Turkey , and.
authors.forename: Zülbiye
authors.initials: Z
authors.lastname: Yılmaz
authors.affiliation: a Department of Biochemistry , Istanbul Medical Faculty, Istanbul University , Istanbul , Turkey , and.
authors.forename: Esra Betül
authors.initials: EB
authors.lastname: Kalaz
authors.affiliation: a Department of Biochemistry , Istanbul Medical Faculty, Istanbul University , Istanbul , Turkey , and.
authors.forename: A Fatih
authors.initials: AF
authors.lastname: Aydın
authors.affiliation: b Department of Pathology, Oncology Institute , Istanbul University , Istanbul , Turkey.
authors.forename: Merva
authors.initials: M
authors.lastname: Soluk-Tekkeşin
authors.affiliation: a Department of Biochemistry , Istanbul Medical Faculty, Istanbul University , Istanbul , Turkey , and.
authors.forename: Semra
authors.initials: S
authors.lastname: Doğru-Abbasoğlu
authors.affiliation: a Department of Biochemistry , Istanbul Medical Faculty, Istanbul University , Istanbul , Turkey , and.
authors.forename: Müjdat
authors.initials: M
authors.lastname: Uysal
authors.affiliation: a Department of Biochemistry , Istanbul Medical Faculty, Istanbul University , Istanbul , Turkey , and.
authors.forename: Necla
authors.initials: N
authors.lastname: Koçak-Toker
mesh_terms: D062107:Advanced Oxidation Protein Products / Q000819:agonists / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002336:Carnosine / Q000494:pharmacology*; D017127:Glycation End Products, Advanced / Q000819:agonists / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D050050:Protein Carbonylation; D011765:Pyruvaldehyde / Q000037:antagonists & inhibitors* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D062107:Advanced Oxidation Protein Products; D000975:Antioxidants; D017127:Glycation End Products, Advanced; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D011765:Pyruvaldehyde; D002336:Carnosine
keywords: Dicarbonyl stress; advanced glycation end products; advanced oxidation products of protein; imidazole dipeptide; protein carbonyl