title: Recalcitrant hypertrophic herpes genitalis in HIV-infected patient successfully treated with topical imiquimod.
abstract: Herpes Simplex Virus type 2 is the primary cause of genital ulceration worldwide. The presence of atypical features like deep ulcerations, hypertrophic, or pseudotumoural lesions or unusual location can be a marker for co-infection with HIV. These immunocompromised patients are usually resistant to the conventional antiviral treatment. We present a case of an HIV-infected patient with hypertrophic herpes genitalis, refractory to conventional oral antiviral therapy, who was successfully treated with a combination of oral valcyclovir and topical application of 5% imiquimod.
authors.affiliation: Department of Dermatology, Venereology and Leprosy, Post Graduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi, 110001, India.
authors.forename: Sidharth
authors.initials: S
authors.lastname: Tandon
authors.affiliation: Department of Dermatology, Venereology and Leprosy, Post Graduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi, 110001, India.
authors.forename: Jasmeet
authors.identifier: http://orcid.org/0000-0002-1933-273X
authors.initials: J
authors.lastname: Singh
authors.affiliation: Department of Dermatology, Venereology and Leprosy, Post Graduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi, 110001, India.
authors.forename: Surabhi
authors.initials: S
authors.lastname: Sinha
authors.affiliation: Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, 110029, India.
authors.forename: Dr Preeti
authors.initials: DP
authors.lastname: Sharma
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000031:analogs & derivatives; D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000287:Administration, Topical; D000634:Aminoquinolines / Q000008:administration & dosage*; D000998:Antiviral Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000276:immunology*; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D006984:Hypertrophy; D000077271:Imiquimod; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D000077483:Valacyclovir; D014633:Valine / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000998:Antiviral Agents; D014633:Valine; D000077483:Valacyclovir; D000077271:Imiquimod; D000212:Acyclovir
keywords: HIV; herpes; hypertrophic; imiquimod; topical