title: A Review of Structure Construction of Silk Fibroin Biomaterials from Single Structures to Multi-Level Structures.
abstract: The biological performance of artificial biomaterials is closely related to their structure characteristics. Cell adhesion, migration, proliferation, and differentiation are all strongly affected by the different scale structures of biomaterials. Silk fibroin (SF), extracted mainly from silkworms, has become a popular biomaterial due to its excellent biocompatibility, exceptional mechanical properties, tunable degradation, ease of processing, and sufficient supply. As a material with excellent processability, SF can be processed into various forms with different structures, including particulate, fiber, film, and three-dimensional (3D) porous scaffolds. This review discusses and summarizes the various constructions of SF-based materials, from single structures to multi-level structures, and their applications. In combination with single structures, new techniques for creating special multi-level structures of SF-based materials, such as micropatterning and 3D-printing, are also briefly addressed.
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China. qjy1540945317@163.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Qi
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China. whui@suda.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China. weikai@suda.edu.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Wei
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China. ldxyyang@126.com.
authors.forename: Ya
authors.initials: Y
authors.lastname: Yang
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China. ruyuezheng92@126.com.
authors.forename: Ru-Yue
authors.initials: RY
authors.lastname: Zheng
authors.affiliation: Nano Fusion Technology Research Lab, Interdisciplinary Cluster for Cutting Edge Research (ICCER), Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Shinshu University, Ueda, Nagano 386 8567, Japan. kim@shinshu-u.ac.jp.
authors.forename: Ick Soo
authors.initials: IS
authors.lastname: Kim
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China. kqzhang@suda.edu.cn.
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001704:Biopolymers / Q000737:chemistry; D012831:Bombyx; D004337:Drug Carriers / Q000737:chemistry; D005349:Fibroins / Q000737:chemistry*; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D016062:Porosity; D066330:Printing, Three-Dimensional; D047011:Silk / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D001704:Biopolymers; D004337:Drug Carriers; D047011:Silk; D005349:Fibroins
keywords: biomaterials; silk fibroin; structure