title: Efficacy of a mixture of probiotic agents as complementary therapy for chronic functional constipation in childhood.
abstract: BACKGROUND
  About 30% of constipated children continue to struggle with constipation beyond puberty. Growing interest has recently raised on the use of probiotics as complementary therapy for FC, in order to prevent the possible PEG-related intestinal dysbiosis. Our study aimed at evaluating the effect on childhood FC of a probiotic mixture (PM), including Bifidobacteria breve M-16 V®, infantis M-63®, and longum BB536®.
  
  
  METHODS
  Fifty-five consecutive children suffering from FC were randomly assigned into two groups: group A received a daily oral combination of PEG plus PM and group B received oral PEG only. Physical and clinical data were collected from each patient at week-1, week-2, week-4, and week-8.
  
  
  RESULTS
  After 1 month, children who experienced improvement in the PEG and in the PEG + PM group were 88 and 81.8%, respectively (p = 0.24). After 1 month from the end of the study treatment, a positive trend towards a higher rate of clinical remission was observed within children treated with PM compared to those who took only PEG (percentage of children off therapy: 64 vs 52, respectively; p = 0.28).
  
  
  CONCLUSIONS
  PEG and PEG + PM are equally effective and safe in the treatment of children with chronic constipation. Nevertheless, further studies are needed to show if adding Bifidobacteria strains to conventional therapy may lead to a better long-term outcome.
authors.affiliation: Department of Translational Medical Science, Section of Pediatrics, "Federico II" University of Naples, Via S. Pansini, 5, 80131, Naples, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Russo
authors.affiliation: Department of Translational Medical Science, Section of Pediatrics, "Federico II" University of Naples, Via S. Pansini, 5, 80131, Naples, Italy.
authors.forename: Francesca Paola
authors.initials: FP
authors.lastname: Giugliano
authors.affiliation: Department of Translational Medical Science, Section of Pediatrics, "Federico II" University of Naples, Via S. Pansini, 5, 80131, Naples, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Quitadamo
authors.affiliation: Department of Translational Medical Science, Section of Pediatrics, "Federico II" University of Naples, Via S. Pansini, 5, 80131, Naples, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Mancusi
authors.affiliation: Department of Translational Medical Science, Section of Pediatrics, "Federico II" University of Naples, Via S. Pansini, 5, 80131, Naples, Italy.
authors.forename: Erasmo
authors.initials: E
authors.lastname: Miele
authors.affiliation: Department of Translational Medical Science, Section of Pediatrics, "Federico II" University of Naples, Via S. Pansini, 5, 80131, Naples, Italy. staiano@unina.it.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Staiano
mesh_terms: D000284:Administration, Oral; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D000529:Complementary Therapies / Q000379:methods*; D003248:Constipation / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D003672:Defecation / Q000187:drug effects / Q000502:physiology*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D019936:Probiotics / Q000627:therapeutic use*; D012741:Sexual Maturation; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations
keywords: Constipation; Polyethylene glycol; Probiotics