title: Biochemical markers of type 2 diabetes as a late complication of myocardial infarction: a case-control study.
abstract: BACKGROUND
  On average, 19-23% of patients with acute myocardial infarction (MI) suffer from type 2 diabetes mellitus, which is newly diagnosed in a significant number of patients. Both classic carbohydrate metabolism and lipid metabolism may be promising diagnostic markers for insulin resistance in acute coronary syndrome.
  
  
  METHODS
  Two hundred patients (130 males and 70 females aged 61.4 ±1.12 years) with ST-segment elevation MI were included in the study. Patients were divided into two groups based on manifestations of diabetes: (1) 171 patients without diabetes within 1 year after MI; and (2) 29 patients with manifestations of diabetes. The control group comprised 33 people without diseases of the cardiovascular system and diabetes and was matched by age and gender with patients.
  
  
  RESULTS
  In patients with an imbalanced adipokine state during the acute phase of MI, we noted an increased concentration of free fatty acids (p> 0.05) and reduced ghrelin levels (p> 0.05) and activation of the proinflammatory and thrombotic potentials of blood plasma. Patients who developed diabetes 1 year after MI showed hospital stays with more pronounced changes in the study parameters.
  
  
  CONCLUSIONS
  The most informative biochemical parameters associated with the development of diabetes at 1 year after MI were adiponectin, retinol protein, ghrelin, tumor necrosis factor α, and plasminogen activator inhibitor.
authors.affiliation: Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Barbarash
authors.affiliation: Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Gruzdeva
authors.affiliation: Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
authors.forename: Evgenya
authors.initials: E
authors.lastname: Uchasova
authors.affiliation: Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Belik
authors.affiliation: Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Dyleva
authors.affiliation: Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
authors.forename: Victoria
authors.initials: V
authors.lastname: Karetnikova
keywords: adipokines; ghrelin; myocardial infarction; tumor necrosis factor α; type 2 diabetes mellitus