title: Tuberculous periprosthetic infection precipitated by infliximab therapy.
abstract: Biological therapy with TNF-α inhibitors have been increasingly used in the treatment of inflammatory arthritis. Systemic tuberculosis infections are often known to occur following treatment with these biological agents. However, no case of periprosthetic tuberculous infection of the hip following this therapy has been reported. We report a case of a 45-year-old man who developed periprosthetic tuberculous infection soon after infliximab injection. We also discuss the need of pretreatment awareness, high index of suspicion, early diagnosis and management of such case.
authors.affiliation: Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, Delhi, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Malhotra
authors.affiliation: Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, Delhi, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Gautam
authors.affiliation: Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, Delhi, India.
authors.forename: Naman
authors.initials: N
authors.lastname: Wahal
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects; D006622:Hip Prosthesis; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D000069285:Infliximab / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology; D016459:Prosthesis-Related Infections / Q000000981:diagnostic imaging / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D014394:Tuberculosis, Osteoarticular / Q000000981:diagnostic imaging / Q000209:etiology*
chemical_list: D018501:Antirheumatic Agents; D007166:Immunosuppressive Agents; D000069285:Infliximab