title: Utilizing Forced Vital Capacity to Predict Low Lung Compliance and Select Intraoperative Tidal Volume During Thoracic Surgery.
abstract: Tidal volume selection during mechanical ventilation utilizes dogmatic formulas that only consider a patient's predicted body weight (PBW). In this study, we investigate whether forced vital capacity (FVC) (1) correlates better to total lung capacity (TLC) than PBW, (2) predicts low pulmonary compliance, and (3) provides an alternative method for tidal volume selection.
  
  
  
  One hundred thirty thoracic surgery patients had their preoperative TLC calculated via 2 methods: (1) pulmonary function test (PFT; TLCPFT) and (2) computed tomography 3D reconstruction (TLCCT). We compared the correlation between TLC and PBW with the correlation between TLC and FVC to determine which was stronger. Dynamic pulmonary compliance was then calculated from intraoperative ventilator data and logistic regression models constructed to determine which clinical measure best predicted low compliance. Ratios of tidal volume/FVC plotted against peak inspiratory pressure were utilized to construct a new model for tidal volume selection. Calculated tidal volumes generated by this model were then compared with those generated by the standard lung-protective formula Vt = 7 cc/kg.
  
  
  
  The correlation between FVC and TLC (0.82 for TLCPFT and 0.76 for TLCCT) was stronger than the correlation between PBW and TLC (0.65 for TLCPFT and 0.58 for TLCCT). Patients with very low compliance had significantly smaller lung volumes (forced expiratory volume at 1 second, FVC, TLC) and lower diffusion capacity of the lungs for carbon monoxide when compared with patients with normal compliance. An FVC cutoff of 3470 cc was 100% sensitive and 51% specific for predicting low compliance. The proposed equation Vt = FVC/8 significantly reduced calculated tidal volume by a mean of 22.5% in patients with low pulmonary compliance without affecting the mean tidal volume in patients with normal compliance (mean difference 0.9%).
  
  
  
  FVC is more strongly correlated to TLC than PBW and a cutoff of about 3.5 L can be utilized to predict low pulmonary compliance. The equation Vt = FVC/8 reduced mean calculated tidal volume in patients with low pulmonary compliance and/or small lungs.
authors.affiliation: From the Departments of Anesthesiology and Perioperative Medicine.
authors.forename: Nir
authors.initials: N
authors.lastname: Hoftman
authors.affiliation: From the Departments of Anesthesiology and Perioperative Medicine.
authors.forename: Eric
authors.initials: E
authors.lastname: Eikermann
authors.affiliation: From the Departments of Anesthesiology and Perioperative Medicine.
authors.forename: John
authors.initials: J
authors.lastname: Shin
authors.affiliation: From the Departments of Anesthesiology and Perioperative Medicine.
authors.forename: Jack
authors.initials: J
authors.lastname: Buckley
authors.affiliation: From the Departments of Anesthesiology and Perioperative Medicine.
authors.forename: Kaveh
authors.initials: K
authors.lastname: Navab
authors.affiliation: Radiology.
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Abtin
authors.affiliation: Medicine Statistics Core, University of California, Los Angeles, California.
authors.forename: Tristan
authors.initials: T
authors.lastname: Grogan
authors.affiliation: From the Departments of Anesthesiology and Perioperative Medicine.
authors.forename: Maxime
authors.initials: M
authors.lastname: Cannesson
authors.affiliation: From the Departments of Anesthesiology and Perioperative Medicine.
authors.forename: Aman
authors.initials: A
authors.lastname: Mahajan
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology*; D006801:Humans; D008170:Lung Compliance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D011237:Predictive Value of Tests; D019616:Thoracic Surgical Procedures / Q000379:methods* / Q000639:trends; D013990:Tidal Volume / Q000502:physiology*; D014797:Vital Capacity / Q000502:physiology*