title: Noninvasive scoring system for significant inflammation related to chronic hepatitis B.
abstract: Although a liver stiffness measurement-based model can precisely predict significant intrahepatic inflammation, transient elastography is not commonly available in a primary care center. Additionally, high body mass index and bilirubinemia have notable effects on the accuracy of transient elastography. The present study aimed to create a noninvasive scoring system for the prediction of intrahepatic inflammatory activity related to chronic hepatitis B, without the aid of transient elastography. A total of 396 patients with chronic hepatitis B were enrolled in the present study. Liver biopsies were performed, liver histology was scored using the Scheuer scoring system, and serum markers and liver function were investigated. Inflammatory activity scoring models were constructed for both hepatitis B envelope antigen (+) and hepatitis B envelope antigen (-) patients. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve were 86.00%, 84.80%, 62.32%, 95.39%, and 0.9219, respectively, in the hepatitis B envelope antigen (+) group and 91.89%, 89.86%, 70.83%, 97.64%, and 0.9691, respectively, in the hepatitis B envelope antigen (-) group. Significant inflammation related to chronic hepatitis B can be predicted with satisfactory accuracy by using our logistic regression-based scoring system.
authors.affiliation: Department of Traditional Chinese Medicine, Zhongshan Hospital Xiamen University, Xiamen, 361004 Fujian, China.
authors.forename: Mei-Zhu
authors.initials: MZ
authors.lastname: Hong
authors.affiliation: Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, New Taipei City, 24205 Taiwan.
authors.forename: Linglong
authors.initials: L
authors.lastname: Ye
authors.affiliation: Department of Gastroenterology, People's Hospital of Rizhao, Rizhao, 276800 Shandong, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Jin
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital affiliated to Xiamen University, Xiamen, 361004 Fujian, China.
authors.forename: Yan-Dan
authors.initials: YD
authors.lastname: Ren
authors.affiliation: Hepatology Unit and Department of Infectious Diseases, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, 361001 Fujian, China.
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Yu
authors.affiliation: Department of Infectious Diseases, the First Affiliated Hospital of Xiamen University, Xiamen, 361004 Fujian, China.
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Liu
authors.affiliation: Hepatology Unit and Department of Infectious Diseases, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, 361001 Fujian, China.
authors.forename: Ru-Mian
authors.initials: RM
authors.lastname: Zhang
authors.affiliation: Department of Statistics, School of Economics, Xiamen University, Xiamen, 361002 Fujian, China.
authors.forename: Kuangnan
authors.initials: K
authors.lastname: Fang
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital affiliated to Xiamen University, Xiamen, 361004 Fujian, China.
authors.forename: Jin-Shui
authors.initials: JS
authors.lastname: Pan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006513:Hepatitis B e Antigens / Q000378:metabolism; D006515:Hepatitis B virus / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000473:pathology / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000821:virology*; D008099:Liver / Q000473:pathology / Q000821:virology*; D016015:Logistic Models; D008297:Male; D011237:Predictive Value of Tests; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D006513:Hepatitis B e Antigens