title: Inflammatory cytokine response and reduced heart rate variability in newborns with hypoxic-ischemic encephalopathy.
abstract: To determine whether systemic inflammation-modulating cytokine expression is related to heart rate variability (HRV) in newborns with hypoxic-ischemic encephalopathy (HIE).
  
  
  
  The data from 30 newborns with HIE were analyzed. Cytokine levels (IL-2, IL-4, IL-6, IL-8, IL-10, IL-13, IL-1β, TNF-α, IFN-λ) were measured either at 24 h of cooling (n=5), 72 h of cooling (n=4) or at both timepoints (n=21). The following HRV metrics were quantified in the time domain: alpha_S, alpha_L, root mean square (RMS) at short time scales (RMS_S), RMS at long time scales (RMS_L), while low-frequency power (LF) and high-frequency power (HF) were quantified in the frequency domain. The relationships between HRV metrics and cytokines were evaluated using mixed-models.
  
  
  
  IL-6, IL-8, IL-10, and IL-13 levels were inversely related to selected HRV metrics.
  
  
  
  Inflammation-modulating cytokines may be important mediators in the autonomic dysfunction observed in newborns with HIE.
authors.affiliation: Division of Fetal and Transitional Medicine, Fetal Medicine Institute, Children's National Health System, Washington, DC USA.
authors.forename: T
authors.initials: T
authors.lastname: Al-Shargabi
authors.affiliation: Division of Fetal and Transitional Medicine, Fetal Medicine Institute, Children's National Health System, Washington, DC USA.|The George Washington University, Washington, DC, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Govindan
authors.affiliation: The George Washington University, Washington, DC, USA.
authors.forename: R
authors.initials: R
authors.lastname: Dave
authors.affiliation: Division of Fetal and Transitional Medicine, Fetal Medicine Institute, Children's National Health System, Washington, DC USA.
authors.forename: M
authors.initials: M
authors.lastname: Metzler
authors.affiliation: Division of Biostatistics and Study Methodology, Children's National Health System, Washington, DC, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Division of Fetal and Transitional Medicine, Fetal Medicine Institute, Children's National Health System, Washington, DC USA.|The George Washington University, Washington, DC, USA.
authors.forename: A
authors.initials: A
authors.lastname: du Plessis
authors.affiliation: Division of Fetal and Transitional Medicine, Fetal Medicine Institute, Children's National Health System, Washington, DC USA.|The George Washington University, Washington, DC, USA.|Division of Neonatology, Children's National Health System, Washington, DC, USA.
authors.forename: A N
authors.initials: AN
authors.lastname: Massaro
mesh_terms: D015415:Biomarkers / Q000097:blood; D001919:Bradycardia / Q000209:etiology; D016207:Cytokines / Q000097:blood*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood* / Q000150:complications; D007231:Infant, Newborn; D007249:Inflammation / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012044:Regression Analysis
chemical_list: D015415:Biomarkers; D016207:Cytokines