title: An additive-multiplicative mean residual life model for right-censored data.
abstract: Many studies have focused on determining the effect of the body mass index (BMI) on the mortality in different cohorts. In this article, we propose an additive-multiplicative mean residual life (MRL) model to assess the effects of BMI and other risk factors on the MRL function of survival time in a cohort of Chinese type 2 diabetic patients. The proposed model can simultaneously manage additive and multiplicative risk factors and provide a comprehensible interpretation of their effects on the MRL function of interest. We develop an estimation procedure through pseudo partial score equations to obtain parameter estimates. We establish the asymptotic properties of the proposed estimators and conduct simulations to demonstrate the performance of the proposed method. The application of the procedure to a study on the life expectancy of type 2 diabetic patients reveals new insights into the extension of the life expectancy of such patients.
authors.affiliation: Department of Statistics, Sun Yat-sen University, China.
authors.forename: Jingheng
authors.initials: J
authors.lastname: Cai
authors.affiliation: College of Mathematics and Statistics, Shenzhen University, China.
authors.forename: Haijin
authors.initials: H
authors.lastname: He
authors.affiliation: Shenzhen Research Institute & Department of Statistics, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Xinyuan
authors.identifier: http://orcid.org/0000-0002-4877-3200
authors.initials: X
authors.lastname: Song
authors.affiliation: Institute of Applied Mathematics, Chinese Academy of Sciences, China.
authors.forename: Liuquan
authors.initials: L
authors.lastname: Sun
mesh_terms: D015992:Body Mass Index; D002681:China; D003198:Computer Simulation; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000401:mortality; D004812:Epidemiologic Methods; D006801:Humans; D015233:Models, Statistical; D012307:Risk Factors; D016019:Survival Analysis
keywords: Additive-multiplicative model; Estimating equations; Mean residual life function; Survival data