title: Conducting the finale of DNA replication.
abstract: Anomalies in dismantling the machinery of DNA replication can compromise genome integrity and contribute to tumorigenesis and aging. In this issue ofGenes & Development, Dewar and colleagues (pp. 275-290) identified an E3 ubiquitin ligase, CUL2LRR2, that modifies a subunit of the replicative CMG (Cdc45, minichromosome maintenance [MCM] subunits 2-7, and the GINS complex) helicase and triggers disassembly of the replication machinery. Their study offers critical insight into the mechanism of DNA replication termination while at the same time raising important questions for future research.
authors.affiliation: Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, California 94720, USA.|Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA.
authors.forename: David
authors.initials: D
authors.lastname: Akopian
authors.affiliation: Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, California 94720, USA.|Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Rape
mesh_terms: D018797:Cell Cycle Proteins / Q000235:genetics; D004265:DNA Helicases / Q000235:genetics*; D004261:DNA Replication; D006801:Humans; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
chemical_list: D018797:Cell Cycle Proteins; D044767:Ubiquitin-Protein Ligases; D004265:DNA Helicases
keywords: CMG; DNA replication; p97; replication termination; ubiquitin