title: Node-positive cutaneous squamous cell carcinoma of the head and neck: Survival, high-risk features, and adjuvant chemoradiotherapy outcomes.
abstract: Data lacks to guide treatment of regionally metastatic cutaneous head and neck squamous cell carcinoma (HNSCC).
  
  
  
  We conducted a retrospective review of 80 patients treated for regionally metastatic cutaneous HNSCC. The effect of various clinicopathologic variables on overall survival (OS) was investigated, in addition to outcomes by treatment modality.
  
  
  
  On multivariate regression, cutaneous primary >2 cm (p = .03) and extracapsular spread (ECS; p = .01) were significantly associated with decreased OS. Location of regional metastasis (neck vs parotid vs both) had no effect on OS (p = .2), nor did the presence of a cutaneous primary at the time of presentation (p = .9). The 3-year survival was 43%, 52%, and 49% for surgery alone, adjuvant radiation, and adjuvant chemoradiation, respectively. Fifty-one percent of patients had a recurrence of their disease.
  
  
  
  Regionally metastatic cutaneous HNSCC is an aggressive disease associated with high recurrence rates. Patients with tumors >2 cm and ECS have poorer OS despite adjuvant therapy. © 2017 Wiley Periodicals, Inc. Head Neck 39: 881-885, 2017.
authors.affiliation: Department of Otolaryngology, Stanford University Medical Center, Stanford, California.
authors.forename: Misha
authors.initials: M
authors.lastname: Amoils
authors.affiliation: Department of Dermatology, Stanford University Medical Center, Stanford, California.
authors.forename: Carolyn S
authors.initials: CS
authors.lastname: Lee
authors.affiliation: Department of Otolaryngology, Stanford University Medical Center, Stanford, California.
authors.forename: John
authors.initials: J
authors.lastname: Sunwoo
authors.affiliation: Department of Dermatology, Stanford University Medical Center, Stanford, California.
authors.forename: Sumaira Z
authors.initials: SZ
authors.lastname: Aasi
authors.affiliation: Department of Radiation Oncology, Stanford University Medical Center, Stanford, California.
authors.forename: Wendy
authors.initials: W
authors.lastname: Hara
authors.affiliation: Department of Dermatopathology, Stanford University Medical Center, Stanford, California.
authors.forename: Jinah
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology, Stanford University Medical Center, Stanford, California.
authors.forename: Davud
authors.initials: D
authors.lastname: Sirjani
authors.affiliation: Department of Oncology, Stanford University Medical Center, Stanford, California.
authors.forename: A Dimitrios
authors.initials: AD
authors.lastname: Colevas
authors.affiliation: Department of Dermatology, Stanford University Medical Center, Stanford, California.
authors.forename: Anne Lynn S
authors.initials: AL
authors.lastname: Chang
authors.affiliation: Department of Otolaryngology, Stanford University Medical Center, Stanford, California.
authors.forename: Vasu
authors.initials: V
authors.lastname: Divi
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D059186:Chemoradiotherapy, Adjuvant; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D000077195:Squamous Cell Carcinoma of Head and Neck; D015996:Survival Rate; D016896:Treatment Outcome
keywords: cutaneous squamous cell carcinoma; head and neck neoplasms; high-risk disease; regional metastases; survival outcomes