title: Recent advances in Epilepsy Research in India.
abstract: There are more than 10 million persons with epilepsy (PWE) in India. Despite availability of antiepileptic drugs (AEDs), there is a large treatment gap varying from 50 to 70% among PWE. For treatable epilepsy, this gap can be attributed to poor education, poverty, cultural beliefs, stigma, and poor healthcare infrastructure; whereas for chronic epilepsy, this gap can be attributed to lack of proper diagnosis and treatment. To prevent, treat, and cure epilepsy, researchers worldwide have made exciting advances across all areas of epilepsy research. Studies carried out in India have also shown substantial progress; however, most of them are focused on the epidemiological aspects of epilepsy, genetic associations, identification, and validation of new AEDs in animal models of epilepsy.Very few studies are reported on understanding the process of epileptogenesis, a dynamic process by which neurons begin to display abnormal firing patterns that cause epileptic seizures. Animal epilepsy models can be used for in depth studies; however, studies conducted on resected brain tissues from epilepsy patients are clinically relevant. Finally, more funding support from government and collaborations among basic research institutes, medical institutes, as well as industries is required to raise the standards of epilepsy research in India.This review focuses on the evaluation of the current status of epilepsy research in India and the need to identify potential anti-epileptogenic interventions.
authors.affiliation: Center of Excellence for Epilepsy, A joint NBRC-AIIMS Collaboration, NBRC, Manesar, India.
authors.forename: Aparna B
authors.initials: AB
authors.lastname: Dixit
authors.affiliation: Center of Excellence for Epilepsy, A joint NBRC-AIIMS Collaboration, NBRC, Manesar, India.
authors.forename: Jyotirmoy
authors.initials: J
authors.lastname: Banerjee
authors.affiliation: Department of Neurosurgery, AIIMS, New Delhi, India.
authors.forename: P Sarat
authors.initials: PS
authors.lastname: Chandra
authors.affiliation: Department of Neurology, AIIMS, New Delhi, India.
authors.forename: Manjari
authors.initials: M
authors.lastname: Tripathi
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D000076722:Drug Development; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007194:India; D012106:Research; D012640:Seizures / Q000150:complications / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants