title: α-pyrone derivatives from a marine actinomycete Nocardiopsis sp. YIM M13066.
abstract: Five new α-pyrones namely nocapyrones O-S (2-6) and nocapyrone F (1) were isolated from a deep-sea sediment strain Nocardiopsis sp. YIM M13066. Their structures were elucidated by their NMR spectroscopic data, HR-ESI-MS and crystal X-ray diffraction. Their cytotoxic activities against H1299, HeLa, HL7702, MCF-7, PC3 and U251 cell lines were evaluated.
authors.affiliation: b College of Basic Medicine , Yunnan University of Traditional Chinese Medicine , Kunming , China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences , Shandong University , Jinan , China.
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Sun
authors.affiliation: a Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences , Shandong University , Jinan , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shi
authors.affiliation: a Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences , Shandong University , Jinan , China.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Lu
mesh_terms: D039903:Actinobacteria; D000192:Actinomycetales / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D011753:Pyrones
keywords: crystal X-ray diffraction; cytotoxic activities; nocapyrones O-S; spectroscopic data; α-pyrones