title: Diabetic aggravation of stroke and animal models.
abstract: Cerebral ischemia in diabetics results in severe brain damage. Different animal models of cerebral ischemia have been used to study the aggravation of ischemic brain damage in the diabetic condition. Since different disease conditions such as diabetes differently affect outcome following cerebral ischemia, the Stroke Therapy Academic Industry Roundtable (STAIR) guidelines recommends use of diseased animals for evaluating neuroprotective therapies targeted to reduce cerebral ischemic damage. The goal of this review is to discuss the technicalities and pros/cons of various animal models of cerebral ischemia currently being employed to study diabetes-related ischemic brain damage. The rational use of such animal systems in studying the disease condition may better help evaluate novel therapeutic approaches for diabetes related exacerbation of ischemic brain damage.
authors.affiliation: Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
authors.forename: Ashish K
authors.initials: AK
authors.lastname: Rehni
authors.affiliation: Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
authors.forename: Allen
authors.initials: A
authors.lastname: Liu
authors.affiliation: Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Perez-Pinzon
authors.affiliation: Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address: KDave@med.miami.edu.
authors.forename: Kunjan R
authors.initials: KR
authors.lastname: Dave
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D002544:Cerebral Infarction / Q000188:drug therapy*; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004195:Disease Models, Animal; D006801:Humans; D020521:Stroke / Q000188:drug therapy*
keywords: Focal cerebral ischemia; Global cerebral ischemia; Hemorrhage; Preclinical models; Stroke; Translational research; White matter damage