title: Hyaluronic Acid Conjugated Magnetic Prussian Blue@Quantum Dot Nanoparticles for Cancer Theranostics.
abstract: A multifunctional nanotheranostic agent was developed by conjugating both hyaluronic acid and bovine serum albumin coated CuInS2-ZnS quantum dots onto the surface of magnetic Prussian blue nanoparticles. The obtained nanoagent could serve as an efficient contrast agent to simultaneously enhance near infrared (NIR) fluorescence and magnetic resonance (MR) imaging greatly. The coexistence of magnetic core and CD44 ligand hyaluronic acid was found to largely improve the specific uptake of the nanoagent by CD44 overexpressed HeLa cells upon applying an external magnetic field. Both NIR fluorescence and MR imagingin vivoproved high accumulation of the nanoagent at tumor site due to its excellent CD44 receptor/magnetic dual targeting capability. After intravenous injection of the nanoagent and treatment of external magnetic field, the tumor in nude mice was efficiently ablated upon NIR laser irradiation and the tumor growth inhibition was more than 89.95%. Such nanotheranostic agent is of crucial importance for accurately identifying the size and location of the tumor before therapy, monitoring the photothermal treatment procedure in real-time during therapy, assessing the effectiveness after therapy.
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Yang
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Lijia
authors.initials: L
authors.lastname: Jing
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Xiaoda
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.affiliation: School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Yue
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Dai
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000628:therapy*; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000008:administration & dosage; D005295:Ferrocyanides / Q000008:administration & dosage*; D006367:HeLa Cells; D064593:Heterografts; D006801:Humans; D006979:Hyperthermia, Induced; D007834:Lasers; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles / Q000008:administration & dosage*; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D061848:Optical Imaging / Q000379:methods; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D045663:Quantum Dots / Q000008:administration & dosage*; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D003287:Contrast Media; D004337:Drug Carriers; D005295:Ferrocyanides; D058185:Magnetite Nanoparticles; D017319:Photosensitizing Agents; C000170:ferric ferrocyanide
keywords: Bimodal Imaging; Fe3O4 nanoparticles, Quantum Dots; Photothermal therapy; Prussian blue nanoparticles; Tumor targeting.