title: Effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality: A clinical observation study.
abstract: OBJECTIVE
  To evaluate the effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality.
  
  
  METHODS
  Forty-eight patients diagnosed with gastric ulcer between June 2014 and February 2016 were randomly allocated to the combination therapy group or monotherapy group. The former received hydrotalcite combined with esomeprazole, and the latter received esomeprazole alone, for 8 wk. Twenty-four healthy volunteers were recruited and acted as the healthy control group. Endoscopic ulcer healing was observed using white light endoscopy and narrow band imaging magnifying endoscopy. The composition of collagen fibers, amount of collagen deposition, expression of factor VIII and TGF-β1, and hydroxyproline content were analyzed by Masson staining, immunohistochemistry, immunofluorescent imaging and ELISA.
  
  
  RESULTS
  Following treatment, changes in the gastric microvascular network were statistically different between the combination therapy group and the monotherapy group (P< 0.05). There were significant differences (P< 0.05) in collagen deposition, expression level of Factor VIII and TGF-β1, and hydroxyproline content in the two treatment groups compared with the healthy control group. These parameters in the combination therapy group were significantly higher than in the monotherapy group (P< 0.05). The ratio of collagen I to collagen III was statistically different among the three groups, and was significantly higher in the combination therapy group than in the monotherapy group (P< 0.05).
  
  
  CONCLUSIONS
  Hydrotalcite combined with esomeprazole is superior to esomeprazole alone in improving gastric ulcer healing quality in terms of improving microvascular morphology, degree of structure maturity and function of regenerated mucosa.
authors.affiliation: Rui-Qi Yang, Hua Mao, Li-Yun Huang, Pei-Zhu Su, Min Lu, Department of Digestive Diseases, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, Guangdong Province, China.
authors.forename: Rui-Qi
authors.initials: RQ
authors.lastname: Yang
authors.affiliation: Rui-Qi Yang, Hua Mao, Li-Yun Huang, Pei-Zhu Su, Min Lu, Department of Digestive Diseases, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, Guangdong Province, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Mao
authors.affiliation: Rui-Qi Yang, Hua Mao, Li-Yun Huang, Pei-Zhu Su, Min Lu, Department of Digestive Diseases, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, Guangdong Province, China.
authors.forename: Li-Yun
authors.initials: LY
authors.lastname: Huang
authors.affiliation: Rui-Qi Yang, Hua Mao, Li-Yun Huang, Pei-Zhu Su, Min Lu, Department of Digestive Diseases, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, Guangdong Province, China.
authors.forename: Pei-Zhu
authors.initials: PZ
authors.lastname: Su
authors.affiliation: Rui-Qi Yang, Hua Mao, Li-Yun Huang, Pei-Zhu Su, Min Lu, Department of Digestive Diseases, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, Guangdong Province, China.
authors.forename: Min
authors.initials: M
authors.lastname: Lu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000536:Aluminum Hydroxide / Q000008:administration & dosage*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D003094:Collagen / Q000378:metabolism; D004724:Endoscopy; D064098:Esomeprazole / Q000008:administration & dosage*; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000382:microbiology; D016481:Helicobacter Infections / Q000175:diagnosis / Q000382:microbiology; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism; D007150:Immunohistochemistry; D008276:Magnesium Hydroxide / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000382:microbiology; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D053773:Transforming Growth Factor beta1; C010467:hydrotalcite; D000536:Aluminum Hydroxide; D005169:Factor VIII; D003094:Collagen; D064098:Esomeprazole; D008276:Magnesium Hydroxide; D006909:Hydroxyproline
keywords: Esomeprazole; Gastric ulcer; Hydrotalcite; Quality of ulcer healing