title: Chemical constituents from Swertia mussotii Franch. (Gentianaceae).
abstract: The chemical investigation of ethanolic extract from Swertia mussotii Franch. has resulted in the isolation of 11 compounds which were identified as Orcinol-β-D-glucoside (1), Shamimin (2), Mangiferin (3), Decussatin (4), Bellidifolin (5), Desmethylbellidifolin (6), Protocatechuic acid (7), 1,7-Dihydroxy-3,8-dimethoxyxanthone (8), 1,8-Dihydroxy-3,5-dimethoxyxanthone (9), 1-Hydroxy-3,5-dimethoxyxanthone (10), Telephioidin (11). The chemical structures of these compounds were identified by a combination of spectroscopic analysis and a comparison with those reported in literature. Among them, compounds 1, 2, 7 and 11 were isolated from the genus Swertia for the first time. Moreover, the chemotaxonomic significance of these compounds was summarised. The chemotaxonomic study suggests that there is a close chemotaxonomic relationship between S. mussotii and other species of Swertia, such as S. punicea, S. macrosperma, S. japonica, S. phragmitiphylla, S. chirayita, S. cordata and S. binchuanensis, with presence of compounds 3~6, 8~10. The xanthones and their glycosides may sever as important chemotaxonomic markers of Swertia genus.
authors.affiliation: a Institute of Chemical Engineering , Qinghai University , Xining , China.|c Institute of Biomechanics and Medical Engineering , Tsinghua University , Beijing , China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Wang
authors.affiliation: b Key Laboratory of Tibetan Medicine Research , Northwest Institute of Plateau Biology, Chinese Academy of Sciences , Xining , China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Yuan
authors.affiliation: c Institute of Biomechanics and Medical Engineering , Tsinghua University , Beijing , China.
authors.forename: Huiming
authors.initials: H
authors.lastname: Huang
authors.affiliation: d Department of Industrial Engineering , Tsinghua University , Beijing , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: a Institute of Chemical Engineering , Qinghai University , Xining , China.
authors.forename: Changnian
authors.initials: C
authors.lastname: Cao
authors.affiliation: c Institute of Biomechanics and Medical Engineering , Tsinghua University , Beijing , China.
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: Zhao
mesh_terms: D002965:Classification / Q000379:methods; D029965:Gentianaceae / Q000737:chemistry; D006027:Glycosides / Q000032:analysis / Q000302:isolation & purification; D029967:Swertia / Q000737:chemistry*; D044004:Xanthones / Q000032:analysis / Q000302:isolation & purification
chemical_list: D006027:Glycosides; D044004:Xanthones
keywords: Swertia mussotii Franch; chemotaxonomic; spectroscopic