title: New polyacetylenes from Echinophora cinerea (Boiss.) Hedge et Lamond.
abstract: Echinophora cinerea aerial parts are used in folk medicine to cure gastric diseases and as a food seasoning in cheese and yogurt. Besides several pharmacological effects have been assigned to Echinophora spp., there is no phytochemical investigation on this genus other than our previous publication on flavonoids. An acetone extract of E. cinerea afforded three new (1-3) polyacetylenes, one rare monoterpenoid glycoside as verbenone-5-O-β-D-glycopyranoside (4) and one prenylated coumarin as osthol (5). The structures of all new compounds were elucidated using modern spectroscopic methods, including 2D NMR and mass analyses. The potency of the compounds to induce cell death was determined on SKNMC, PC3 and MCF-7 cell lines using MTT method in which compounds 1 and 2 showed moderate cytotoxic effects, especially against PC3 cells.
authors.affiliation: a Students research Committee, School of Pharmacy , Kermanshah University of Medical Sciences , Kermanshah , Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Jelodarian
authors.affiliation: b Pharmaceutical Sciences Research Center, School of Pharmacy , Kermanshah University of Medical Sciences , Kermanshah , Iran.|c Department of Pharmacognosy and Biotechnology, School of Pharmacy , Kermanshah University of Medical Sciences , Kermanshah , Iran.
authors.forename: Yalda
authors.initials: Y
authors.lastname: Shokoohinia
authors.affiliation: a Students research Committee, School of Pharmacy , Kermanshah University of Medical Sciences , Kermanshah , Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Rashidi
authors.affiliation: b Pharmaceutical Sciences Research Center, School of Pharmacy , Kermanshah University of Medical Sciences , Kermanshah , Iran.
authors.forename: Nastaran
authors.initials: N
authors.lastname: Ghiasvand
authors.affiliation: b Pharmaceutical Sciences Research Center, School of Pharmacy , Kermanshah University of Medical Sciences , Kermanshah , Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Hosseinzadeh
authors.affiliation: d Biotechnology Research Center, School of Pharmacy , Mashhad University of Medical Sciences , Mashhad , Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Iranshahi
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects*; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D061986:MCF-7 Cells; D008519:Medicine, Traditional; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D054876:Prenylation
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D005419:Flavonoids; D006027:Glycosides; D053279:Polyynes; C030123:coumarin
keywords: Echinophora cinerea; Polyacetylene; monoterpenoid glycoside, echinophorin, PC3; verbenone