title: Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes.
abstract: Coordination compounds of 4-hydroxy-3-nitro-2H-chromen-2-one and their mixed ligand complexes with aminoethanoic acid and pyrrolidine-2-carboxylic acid were synthesized by the reaction of Cu(II) and Zn(II) salts in molar ratio 1 : 2 for the coumarin complexes and 1 : 1 : 1 for the mixed ligand complexes, in basic media. The compounds formed were characterized using infrared, Uv-vis spectrophotometric analyses, mass spectrometry, magnetic susceptibility measurements, and EDX analyses. It was concluded that 4-hydroxy-3-nitro-2H-chromen-2-one coordinated as a monobasic ligand for all the complexes; it also coordinated via the carbonyl moiety in the case of the Cu(II) mixed ligand complexes. Similarly it was proposed that the amino acids also coordinated in a bidentate fashion via their amino nitrogen and carboxylate oxygen atoms. The synthesized compounds were screened for their antimicrobial and cytotoxic activities. The complexes exhibited marginal antimicrobial activity but good cytotoxic activity.
authors.affiliation: Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
authors.forename: Temitayo
authors.identifier: 0000-0001-8283-1243
authors.initials: T
authors.lastname: Aiyelabola
authors.affiliation: Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
authors.forename: Ezekiel
authors.initials: E
authors.lastname: Akinkunmi
authors.affiliation: Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
authors.forename: Efere
authors.initials: E
authors.lastname: Obuotor
authors.affiliation: Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
authors.forename: Idowu
authors.initials: I
authors.lastname: Olawuni
authors.affiliation: Department of Chemistry, North-West University, Mafikeng Campus, Mmabatho, South Africa.
authors.forename: David
authors.initials: D
authors.lastname: Isabirye
authors.affiliation: Focus Area Chemical Resource Beneficiation, North-West University, Potchefstroom Campus, Potchefstroom, South Africa.
authors.forename: Johan
authors.initials: J
authors.lastname: Jordaan