title: Candidate Gene Analysis of Breast Cancer in the Jordanian Population of Arab Descent: A Case-Control Study.
abstract: This study aimed to investigate whether there are specific polymorphisms within six genes (BRCA1, BRCA2, TP53, DAPK1, MMP9 promoter, and TOX3) that are associated with breast cancer among the Jordanian population. Sequenom MassARRAY system was used to genotype 17 single nucleotide polymorphisms (SNPs) within these genes in 230 Jordanian breast cancer patients and 225 healthy individuals. Three SNPs (MMP9 (rs6065912), TOX3 (rs1420546), and DAPK1 (rs11141901) were found to be significantly associated with an increased risk of breast cancer (p < .05). This study is the first to provide evidence that genetic variation in MMP9, TOX3, and DAPK1 genes contribute to the development of breast cancer in the Jordanian population.
authors.affiliation: a Department of Applied Biological Sciences , Jordan University of Science and Technology , Irbid , Jordan.|b Department of Biotechnology and Genetic Engineering , Jordan University of Science and Technology , Irbid , Jordan.
authors.forename: Laith N
authors.initials: LN
authors.lastname: Al-Eitan
authors.affiliation: a Department of Applied Biological Sciences , Jordan University of Science and Technology , Irbid , Jordan.|b Department of Biotechnology and Genetic Engineering , Jordan University of Science and Technology , Irbid , Jordan.
authors.forename: Reem I
authors.initials: RI
authors.lastname: Jamous
authors.affiliation: c Department of Hematopathology, King Hussein Medical Center (KHMC) , Jordan Royal Medical Services (RMS) , Amman , Jordan.
authors.forename: Rame H
authors.initials: RH
authors.lastname: Khasawneh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018912:Arabs / Q000235:genetics* / Q000706:statistics & numerical data; D001943:Breast Neoplasms / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007597:Jordan / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
keywords: Breast cancer; Jordanian Arabs; case-control study; genetic association