title: Electrochemical Biosensors for Early Stage Zika Diagnostics.
abstract: Health agencies have declared the recent Zika virus (ZIKV) infection an epidemic and a public health emergency of global concern due to its association with microcephaly and serious neurological disorders. The unavailability of effective drugs, vaccines, and diagnostic tools increases the demand for efficient analytical devices to detect ZIKV infection. However, high costs, longer diagnostic times, and stringent expertise requirements limit the utility of reverse transcriptase-PCR methods for rapid diagnostics. Therefore, developing portable, sensitive, selective, and cost-effective sensing systems to detect ZIKV at picomolar concentrations in biofluids would be a breakthrough in diagnostics and therapeutics. This paper highlights the advancements in developing smart sensing strategies to monitor ZIKV progression, with rapid point-of-care diagnostics as the ultimate aim.
authors.affiliation: Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. Electronic address: ajeet.npl@gmail.com.
authors.forename: Ajeet
authors.initials: A
authors.lastname: Kaushik
authors.affiliation: Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
authors.forename: Sneham
authors.initials: S
authors.lastname: Tiwari
authors.affiliation: Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
authors.forename: Rahul D
authors.initials: RD
authors.lastname: Jayant
authors.affiliation: Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
authors.forename: Arti
authors.initials: A
authors.lastname: Vashist
authors.affiliation: Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
authors.forename: Roozbeh
authors.initials: R
authors.lastname: Nikkhah-Moshaie
authors.affiliation: Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
authors.forename: Nazira
authors.initials: N
authors.lastname: El-Hage
authors.affiliation: Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. Electronic address: nairm@fiu.edu.
authors.forename: Madhavan
authors.initials: M
authors.lastname: Nair
mesh_terms: D000330:Aedes / Q000821:virology; D000818:Animals; D015374:Biosensing Techniques; D042241:Early Diagnosis; D055664:Electrochemical Techniques; D006801:Humans; D046210:Microfluidic Analytical Techniques; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000071244:Zika Virus / Q000235:genetics / Q000302:isolation & purification; D000071243:Zika Virus Infection / Q000175:diagnosis / Q000635:transmission / Q000821:virology
keywords: Zika virus infection; electrochemical biosensor; point-of-care sensing systems