title: "In-bore" MRI-guided Prostate Biopsy Using an Endorectal Nonmagnetic Device: A Prospective Study of 70 Consecutive Patients.
abstract: We investigated the diagnostic performance of in-bore endorectal magnetic resonance imaging-guided biopsy (MRI-GB) with a 1.5-T MRI scanner using a 32-channel coil in patients with suspected prostate cancer (PCa).
  
  
  
  Seventy patients with ≥ 1 suspicious area found on the preliminary multiparametric MRI scan were enrolled. The index lesion was defined as the lesion with the greatest Prostate Imaging Reporting and Data System, version 2 (PIRADS-v2), score. MRI-GBs were performed with a nonmagnetic biopsy device, needle guide, and titanium double-shoot biopsy gun with dedicated software for needle tracking. Clinically significant PCa was defined as the presence of Gleason score ≥ 7 in the biopsy specimen.
  
  
  
  Seventy index lesions were scheduled for MRI-GB. The median PIRADS-v2 score and the median number of cores per patient was 4 of 5 (interquartile range, 3-5) and 2 (interquartile range, 1-3), respectively. The PCa detection rate was 45.7%. Of the 70 patients, 24 (75%) had clinically significant PCa, with a significant correlation between the PIRADS-v2 score and the Gleason score in the MRI-GB cores (r = 0.839; 95% confidence interval, 0.535-0.951; P = .003). According to the PIRADs-v2 scheme, the proportion of PCa in the central and anterior regions of the gland was greater in the entire population and in the subgroup of patients with a history of negative transrectal ultrasound-guided biopsy findings (P ≤ .01 for all). On multivariate analysis, a PIRADS-v2 score of 5 of 5 correlated significantly with the likelihood of PCa at biopsy (hazard ratio, 4.69; 95% confidence interval, 0.92-23.74; P = .04). No major complications were recorded.
  
  
  
  MRI-GB has a high detection rate for PCa, especially for lesions located in the central and anterior regions of the prostate.
authors.affiliation: Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Schiavina
authors.affiliation: Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Vagnoni
authors.affiliation: Department of Urology, Abano Policlinic Hospital, Padua, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: D'Agostino
authors.affiliation: Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy. Electronic address: mark.borghesi1@gmail.com.
authors.forename: Marco
authors.initials: M
authors.lastname: Borghesi
authors.affiliation: Department of Urology, Abano Policlinic Hospital, Padua, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Salvaggio
authors.affiliation: Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Giampaoli
authors.affiliation: Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Cristian V
authors.initials: CV
authors.lastname: Pultrone
authors.affiliation: Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Saraceni
authors.affiliation: Department of Radiology, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Gaudiano
authors.affiliation: Department of Radiology, Abano Policlinic Hospital, Padua, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Vigo
authors.affiliation: Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Bianchi
authors.affiliation: Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Hussam
authors.initials: H
authors.lastname: Dababneh
authors.affiliation: Department of Nephrology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: La Manna
authors.affiliation: Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Chessa
authors.affiliation: Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Romagnoli
authors.affiliation: Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Martorana
authors.affiliation: Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Brunocilla
authors.affiliation: Department of Urology, Abano Policlinic Hospital, Padua, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Porreca
mesh_terms: D000368:Aged; D006801:Humans; D061705:Image-Guided Biopsy / Q000295:instrumentation*; D053783:Magnetic Resonance Imaging, Interventional / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology
chemical_list: D017430:Prostate-Specific Antigen
keywords: Clinically significant disease; Detection rate; Image-guided biopsy; Magnetic resonance imaging; Prostate cancer