title: Highly sensitive detection of human cancer antigens by an immunogold-silver assay chip coupled with a polythiophene-based optical sensor.
abstract: This work presents a novel method for protein or cancer antigen detection in clinical samples by an immunogold-silver assay microfluidic biochip coupled with a polythiophene-based organic photodetector. The method has showed a detection limit below 1ng/mL and the low cost and high sensitivity of both organic photodetector and immunogold-silver assay make this method amenable for realization in a portable handheld probe tip biosensor.
authors.forename: Nuno M M
authors.initials: NM
authors.lastname: Pires
authors.lastname: Tao Dong
mesh_terms: D000951:Antigens, Neoplasm; D015374:Biosensing Techniques; D006801:Humans; D007150:Immunohistochemistry; D057230:Limit of Detection; D044085:Microfluidics; D009369:Neoplasms; D012834:Silver
chemical_list: D000951:Antigens, Neoplasm; D012834:Silver