title: CCR5+ CD8 T-cell levels and monocyte activation precede the onset of acute coronary syndrome in HIV-infected patients on antiretroviral therapy.
abstract: Acute coronary syndrome (ACS) is nowadays one of the leading causes of morbid-mortality in HIV-infected population, but innate and adaptive immune mechanisms preceding this event are unknown. In this work we comprehensively and longitudinally observed, by multiparametric flow cytometry and following a case-control design, increased CCR5+CD8+T-cells levels and monocytes expressing activation and adhesion markers in HIV-infected patients who are going to suffer ACS. In addition, we found direct associations between activated CD8+T-cells and myeloid cells that were only statistically significant in the group of patients with ACS and in the follow up time point just before the ACS. Our data highlight the important role of CCR5 in the onset of ACS and suggest this receptor as a marker of cardiovascular risk and potential therapeutic target to prevent the development of such non-AIDS-related event in HIV-infected patients.
authors.forename: Laura
authors.initials: L
authors.lastname: Tarancon-Diez
authors.forename: Rebeca S
authors.initials: RS
authors.lastname: De Pablo-Bernal
authors.forename: Ana I
authors.initials: AI
authors.lastname: Álvarez-Rios
authors.forename: Isaac
authors.initials: I
authors.lastname: Rosado-Sánchez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Dominguez-Molina
authors.forename: Miguel
authors.initials: M
authors.lastname: Genebat
authors.forename: Yolanda M
authors.initials: YM
authors.lastname: Pacheco
authors.forename: José Luis
authors.initials: JL
authors.lastname: Jiménez
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Muñoz-Fernández
authors.affiliation: Dr. Ezequiel Ruiz-Mateos, PhD, Immunovirology Laboratory (Lab 211), Institute of Biomedicine of Seville, Virgen del Rocío University Hospital, Avda 28 Manuel Siurot s/n CP 41013, Seville, Spain, Tel.: +34 955923107, E-mail: ezequiel.ruizmateos@gmail.com.
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Ruiz-Mateos
authors.forename: Manuel
authors.initials: M
authors.lastname: Leal
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D011379:Prognosis; D019713:Receptors, CCR5 / Q000378:metabolism*; D012306:Risk; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents; D015415:Biomarkers; C584933:CCR5 protein, human; D019713:Receptors, CCR5
keywords: CCR5; HIV; immune activation; monocyte; vascular event