title: [Pulmonary metastasectomy in renal cell carcinoma].
abstract: BACKGROUND
  In patients with isolated meta- or synchronous pulmonary metastases from renal cell cancer, lung metastasectomy could be an appropriate treatment option after successful treatment of primary cancer.
  
  
  OBJECTIVE
  Presentation of lung metastasectomy as a treatment option in patients with pulmonary metastatic renal cell cancer and the postoperative outcome. Description of alternative treatment modalities focusing on "targeted therapies".
  
  
  METHODS
  Systematical literature research and qualitative analysis of studies on patients undergoing lung metastasectomy after primary nephrectomy published since 01 January 2000. We assessed operative findings, survival data, and prognostic factors.
  
  
  RESULTS
  Pulmonary metastasectomy results in a median postmetastasectomy survival of 26-94 months. The 5‑year survival rates vary between 33 and 58%. The patients' prognosis depends on a prolonged disease-free interval and complete resection of all suspected metastases. In particular, number and location of lung metastases should play a minor role for the indication for lung metastasectomy.
  
  
  CONCLUSIONS
  Pulmonary metastasectomy should be considered the treatment of choice in selected patients with successfully resected primary cancer showing no evidence of extrapulmonary metastases and having guaranteed operability and complete resection.
authors.affiliation: Medizinische Fakultät, Universität zu Köln, Joseph-Stelzmann-Straße 20, 50931, Köln, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Macherey
authors.affiliation: Klinik für Urologie, Uro-Onkologie, spezielle urologische und roboter-assistierte Chirurgie, Universität zu Köln, Kerpener Straße 62, 50931, Köln, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Kauffmann
authors.affiliation: Klinik für Urologie, Uro-Onkologie, spezielle urologische und roboter-assistierte Chirurgie, Universität zu Köln, Kerpener Straße 62, 50931, Köln, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Heidenreich
authors.affiliation: Klinik und Poliklinik für Herz- und Thoraxchirurgie, Universität zu Köln, Kerpener Straße 62, 50931, Köln, Deutschland.
authors.forename: F
authors.initials: F
authors.lastname: Doerr
authors.affiliation: Klinik und Poliklinik für Herz- und Thoraxchirurgie, Universität zu Köln, Kerpener Straße 62, 50931, Köln, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Wahlers
authors.affiliation: Klinik und Poliklinik für Herz- und Thoraxchirurgie, Universität zu Köln, Kerpener Straße 62, 50931, Köln, Deutschland. khosro.hekmat@uk-koeln.de.
authors.forename: K
authors.initials: K
authors.lastname: Hekmat
mesh_terms: D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000601:surgery*; D006801:Humans; D007680:Kidney Neoplasms / Q000601:surgery*; D008175:Lung Neoplasms / Q000556:secondary* / Q000601:surgery*; D059146:Metastasectomy; D011183:Postoperative Complications / Q000209:etiology; D011379:Prognosis; D020775:Thoracic Surgery, Video-Assisted; D013908:Thoracotomy
keywords: Lung metastases; Metastasectomy; R0-resection; Renal cell cancer