title: Language ENvironment Analysis (LENA) in Phelan-McDermid Syndrome: Validity and Suggestions for Use in Minimally Verbal Children with Autism Spectrum Disorder.
abstract: Phelan-McDermid syndrome (PMS) is a single-locus cause of developmental delay, autism spectrum disorder, and minimal verbal abilities. There is an urgent need to identify objective outcome measures of expressive language for use in this and other minimally verbal populations. One potential tool is an automated language processor called Language ENvironment Analysis (LENA). LENA was used to obtain over 542 h of audio in 18 children with PMS. LENA performance was adequate in a subset of children with PMS, specifically younger children and those with fewer stereotypic vocalizations. One LENA-derived language measure, Vocalization Ratio, had improved accuracy in this sample and may represent a novel expressive language measure for use in severely affected populations.
authors.affiliation: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.
authors.forename: Jacquelin
authors.identifier: 0000-0002-8072-6762
authors.initials: J
authors.lastname: Rankine
authors.affiliation: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Li
authors.affiliation: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.|Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA.
authors.forename: Stacey
authors.initials: S
authors.lastname: Lurie
authors.affiliation: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.
authors.forename: Hillary
authors.initials: H
authors.lastname: Rieger
authors.affiliation: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Fourie
authors.affiliation: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.|Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Box 1230, One Gustave L. Levy Place, New York, NY, 10029, USA.
authors.forename: Paige M
authors.initials: PM
authors.lastname: Siper
authors.affiliation: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.|Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Box 1230, One Gustave L. Levy Place, New York, NY, 10029, USA.|Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.|Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: A Ting
authors.initials: AT
authors.lastname: Wang
authors.affiliation: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA.|Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Box 1230, One Gustave L. Levy Place, New York, NY, 10029, USA.|Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.|Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.|Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.|Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Buxbaum
authors.affiliation: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, Box 1668, One Gustave L. Levy Place, New York, NY, 10029, USA. alexander.kolevzon@mssm.edu.|Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Box 1230, One Gustave L. Levy Place, New York, NY, 10029, USA. alexander.kolevzon@mssm.edu.|Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. alexander.kolevzon@mssm.edu.|Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. alexander.kolevzon@mssm.edu.|Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. alexander.kolevzon@mssm.edu.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kolevzon
mesh_terms: D000293:Adolescent; D000067877:Autism Spectrum Disorder / Q000175:diagnosis* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000175:diagnosis* / Q000453:epidemiology; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007805:Language Development Disorders / Q000175:diagnosis* / Q000453:epidemiology; D007807:Language Tests / Q000592:standards*; D008297:Male; D015203:Reproducibility of Results; D012931:Social Environment
keywords: 22q13 deletion syndrome; Autism spectrum disorder; Automated vocal analysis; Language ENvironment Analysis; Minimally verbal; Phelan-McDermid syndrome