title: Systemic Regulators of Skeletal Muscle Regeneration in Obesity.
abstract: Skeletal muscle maintenance is a dynamic process and undergoes constant repair and regeneration. However, skeletal muscle regenerative capacity declines in obesity. In this review, we focus on obesity-associated changes in inflammation, metabolism, and impaired insulin signaling, which are pathologically dysregulated and ultimately result in a loss of muscle mass and function. In addition, we examine the relationships between skeletal muscle, liver, and visceral adipose tissue in an obese state.
authors.affiliation: Division of Plastic Surgery, Brigham and Women's Hospital , Boston, MA , USA.
authors.forename: Indranil
authors.initials: I
authors.lastname: Sinha
authors.affiliation: Division of Plastic Surgery, Brigham and Women's Hospital , Boston, MA , USA.
authors.forename: Dharaniya
authors.initials: D
authors.lastname: Sakthivel
authors.affiliation: Division of Plastic Surgery, Brigham and Women's Hospital , Boston, MA , USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Varon
keywords: inflammation; insulin; metabolism; obesity; skeletal muscle