title: Antioxidant, phenolic and antifungal profiles of Acanthus mollis (Acanthaceae).
abstract: Acanthus mollis is used as ornamental and medicinal plant. The ethnopharmacology reports indicate that extracts have anti-inflammatory activity. Phytoconstituents profile was evaluated by estimating the content of anthraquinones, flavonoids and phenols. In addition, the antioxidant activity was evaluated using four methods: Hydrogen atoms transfer (TRAP, ORAC and DPPH assays), and single electron transfer (FRAP assay). Finally, antifungal activity was determined by the M27-A2 test. The results shown that ethanol extracts have the highest concentration of phenols, anthraquinones and flavonoids. Total antioxidant capacity, extracts of ethyl acetate and ethanol are those with the highest activity, which correlates strongly with the presence of phenols. The antifungal activity measured in various strains of Candida is concentrated in ethyl acetate extracts of flower and leaf ethanol, a phenomenon may be related to antioxidant activity.
authors.affiliation: a Laboratorio de Investigación-Estrés Oxidativo, Facultad de Medicina , Centro de Investigaciones Biomédicas (CIB), Universidad de Valparaíso , Valparaíso , Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: Jara
authors.affiliation: b Departamento de Química , Universidad Técnica Federico Santa María , Valparaíso , Chile.
authors.forename: Miguel
authors.initials: M
authors.lastname: Leyton
authors.affiliation: b Departamento de Química , Universidad Técnica Federico Santa María , Valparaíso , Chile.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Osorio
authors.affiliation: c Instituto de Química, Pontiﬁcia Universidad Católica de Valparaíso , Valparaíso , Chile.
authors.forename: Viviana
authors.initials: V
authors.lastname: Silva
authors.affiliation: a Laboratorio de Investigación-Estrés Oxidativo, Facultad de Medicina , Centro de Investigaciones Biomédicas (CIB), Universidad de Valparaíso , Valparaíso , Chile.
authors.forename: Francisco
authors.initials: F
authors.lastname: Fleming
authors.affiliation: a Laboratorio de Investigación-Estrés Oxidativo, Facultad de Medicina , Centro de Investigaciones Biomédicas (CIB), Universidad de Valparaíso , Valparaíso , Chile.
authors.forename: Marilyn
authors.initials: M
authors.lastname: Paz
authors.affiliation: e Departamento de Química , Universidad de Playa Ancha , Valparaíso , Chile.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Madrid
authors.affiliation: b Departamento de Química , Universidad Técnica Federico Santa María , Valparaíso , Chile.|d Facultad de Química y Farmacia , Universidad de Valparaíso , Valparaíso , Chile.
authors.forename: Marco
authors.initials: M
authors.lastname: Mellado
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000032:analysis; D000935:Antifungal Agents / Q000032:analysis*; D000975:Antioxidants / Q000032:analysis* / Q000302:isolation & purification; D020834:Ethnopharmacology; D005419:Flavonoids / Q000737:chemistry; D035264:Flowers / Q000737:chemistry; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts
keywords: Acanthus mollis; antifungal activity; antioxidant activity; phenolic compounds