title: Diffusion and Perfusion MR Imaging in Acute Stroke: Clinical Utility and Potential Limitations for Treatment Selection.
abstract: Magnetic resonance (MR) diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) offer unique insight into acute ischemic stroke pathophysiology. These techniques may offer the ability to apply pathophysiology to accurately individualize acute stroke reperfusion treatment, including extending the opportunity of reperfusion treatment to well beyond the current time-based treatment windows.This review examines the use of DWI and PWI in the major stroke trials, their current clinical utility, and potential limitations for reperfusion treatment selection. DWI and PWI continue to be investigated in ongoing randomized controlled trials, and continued research into these techniques will help achieve the goal of tissue-based decision making and individualized acute stroke treatment.
authors.affiliation: *Neuroradiology Service, Monash Imaging, Monash Health †School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia ‡NeuroEndovascular Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA §Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Mathew
authors.initials: M
authors.lastname: Bateman
authors.forename: Lee-Anne
authors.initials: LA
authors.lastname: Slater
authors.forename: Thabele
authors.initials: T
authors.lastname: Leslie-Mazwi
authors.forename: Claus Z
authors.initials: CZ
authors.lastname: Simonsen
authors.forename: Stephen
authors.initials: S
authors.lastname: Stuckey
authors.forename: Ronil V
authors.initials: RV
authors.lastname: Chandra
mesh_terms: D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D057510:Endovascular Procedures; D059907:Functional Neuroimaging / Q000379:methods; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000000981:diagnostic imaging* / Q000628:therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage
chemical_list: D010959:Tissue Plasminogen Activator