title: Age at symptom onset is not associated with reduced action cancelation in adults with obsessive-compulsive disorder.
abstract: The aim of the current study was to examine the association between age at symptom onset and action cancelation in adults with obsessive-compulsive disorder (OCD). Performance on the stop-signal task was compared among adult patients with early-onset OCD (n=63, onset age ≤19), late-onset OCD (n=33, onset age ≥20), and healthy controls (n=51). Stop-signal reaction time (SSRT) was significantly longer in both OCD groups compared to the control group. However, no significant differences were found between the two OCD groups. In addition, age at symptom onset was not associated with response inhibition performance in adults with OCD. The study findings support the existence of reduced performance on action cancelation in patients with OCD compared to healthy controls with no difference between early- and late-onset OCD subtypes.
authors.affiliation: Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha 410011, PR China; College of Education, Hunan Agriculture University, Changsha 410128, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Lei
authors.affiliation: Center for Studies of Psychological Application, South China Normal University, Guangzhou 510631, PR China.
authors.forename: Mingtian
authors.initials: M
authors.lastname: Zhong
authors.affiliation: Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha 410011, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Fan
authors.affiliation: Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha 410011, PR China.
authors.forename: Xiaocui
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Sociology and Psychology, Southwest University for Nationalities, Chengdu 610041, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Cai
authors.affiliation: Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha 410011, PR China. Electronic address: xiongzhaozhu@163.com.
authors.forename: Xiongzhao
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000523:psychology*; D011930:Reaction Time; D013647:Task Performance and Analysis; D055815:Young Adult
keywords: Action cancelation; Early-onset; Late-onset; Obsessive-compulsive disorder; Response inhibition