title: Sesquiterpene constituents from the soft coral Sinularia nanolobata.
abstract: Using various chromatographic separations, four sesquiterpenes (1-4), including two new compounds, nanolobatols A and B (1 and 2), were isolated from the Vietnamese soft coral Sinularia nanolobata. Their structures were determined on the basis of spectroscopic data (1H and13C NMR, HSQC, HMBC,1H-1H COSY, NOESY and FT-ICR-MS) and by comparison with the literature values. The cytotoxic activity of isolated compounds against a panel of eight human cancer cell lines was also evaluated.
authors.affiliation: a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.|b Graduate University of Science and Technology, VAST , Hanoi , Vietnam.
authors.forename: Ninh Thi
authors.initials: NT
authors.lastname: Ngoc
authors.affiliation: a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Pham Thi Mai
authors.initials: PTM
authors.lastname: Huong
authors.affiliation: a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.|b Graduate University of Science and Technology, VAST , Hanoi , Vietnam.
authors.forename: Nguyen Van
authors.initials: NV
authors.lastname: Thanh
authors.affiliation: a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.|b Graduate University of Science and Technology, VAST , Hanoi , Vietnam.
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Cuong
authors.affiliation: a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Nguyen Hoai
authors.initials: NH
authors.lastname: Nam
authors.affiliation: c Institute of Marine Environment and Resources, VAST , Haiphong , Vietnam.
authors.forename: Do Cong
authors.initials: DC
authors.lastname: Thung
authors.affiliation: a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.affiliation: a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C000624885:nanolobatol A
keywords: Alcyoniidae; Sinularia nanolobata; sesquiterpene; soft coral