title: Aarhus Regenerative Orthopaedics Symposium (AROS).
abstract: The combination of modern interventional and preventive medicine has led to an epidemic of ageing. While this phenomenon is a positive consequence of an improved lifestyle and achievements in a society, the longer life expectancy is often accompanied by decline in quality of life due to musculoskeletal pain and disability. The Aarhus Regenerative Orthopaedics Symposium (AROS) 2015 was motivated by the need to address regenerative challenges in an ageing population by engaging clinicians, basic scientists, and engineers. In this position paper, we review our contemporary understanding of societal, patient-related, and basic science-related challenges in order to provide a reasoned roadmap for the future to deal with this compelling and urgent healthcare problem.
authors.affiliation: a Orthopaedic Research Laboratory , Aarhus University Hospital , Denmark.|b Department of Orthopaedics , Aarhus University Hospital , Denmark.
authors.forename: Casper B
authors.initials: CB
authors.lastname: Foldager
authors.affiliation: b Department of Orthopaedics , Aarhus University Hospital , Denmark.
authors.forename: Michael
authors.initials: M
authors.lastname: Bendtsen
authors.affiliation: c Department of Large Animal Science , University of Copenhagen , Denmark.
authors.forename: Lise C
authors.initials: LC
authors.lastname: Berg
authors.affiliation: d Division of Biochemistry, Faculty of Medicine , University of Oslo , Norway.
authors.forename: Jan E
authors.initials: JE
authors.lastname: Brinchmann
authors.affiliation: e Department of Orthopaedics , Sahlgrenska University Hospital, University of Gothenburg , Sweden.
authors.forename: Mats
authors.initials: M
authors.lastname: Brittberg
authors.affiliation: a Orthopaedic Research Laboratory , Aarhus University Hospital , Denmark.|b Department of Orthopaedics , Aarhus University Hospital , Denmark.
authors.forename: Cody
authors.initials: C
authors.lastname: Bunger
authors.affiliation: f Department of Orthopaedics , University of Pennsylvania , PN , USA.
authors.forename: Jose
authors.initials: J
authors.lastname: Canseco
authors.affiliation: g Molecular Endocrinology and Stem Cell Research Unit (KMEB), University of Southern Denmark , Denmark.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: a Orthopaedic Research Laboratory , Aarhus University Hospital , Denmark.
authors.forename: Bjørn B
authors.initials: BB
authors.lastname: Christensen
authors.affiliation: h INSERM UMRS U791, University of Nantes , France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Colombier
authors.affiliation: i Department of Biomedicine , Aarhus University and Department of Rheumatology, Aarhus University Hospital , Denmark.
authors.forename: Bent W
authors.initials: BW
authors.lastname: Deleuran
authors.affiliation: j Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) , University of Oxford , UK.
authors.forename: James
authors.initials: J
authors.lastname: Edwards
authors.affiliation: b Department of Orthopaedics , Aarhus University Hospital , Denmark.
authors.forename: Brian
authors.initials: B
authors.lastname: Elmengaard
authors.affiliation: k Cartilage Restoration Center of Indiana , OrthoIndy , IN , USA.
authors.forename: Jack
authors.initials: J
authors.lastname: Farr
authors.affiliation: e Department of Orthopaedics , Sahlgrenska University Hospital, University of Gothenburg , Sweden.
authors.forename: Birgitta
authors.initials: B
authors.lastname: Gatenholm
authors.affiliation: l Cartilage Repair Center , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Gomoll
authors.affiliation: m Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine , National University of Singapore , Singapore.
authors.forename: James H
authors.initials: JH
authors.lastname: Hui
authors.affiliation: n Department of Orthopaedics , Akershus University Hospital and Institute of Health and Society, University of Oslo , Norway.
authors.forename: Rune B
authors.initials: RB
authors.lastname: Jakobsen
authors.affiliation: a Orthopaedic Research Laboratory , Aarhus University Hospital , Denmark.
authors.forename: Natasja L
authors.initials: NL
authors.lastname: Joergensen
authors.affiliation: g Molecular Endocrinology and Stem Cell Research Unit (KMEB), University of Southern Denmark , Denmark.
authors.forename: Moustapha
authors.initials: M
authors.lastname: Kassem
authors.affiliation: o Department of Biomedical Sciences , University of Guelph , ON , Canada.
authors.forename: Thomas
authors.initials: T
authors.lastname: Koch
authors.affiliation: b Department of Orthopaedics , Aarhus University Hospital , Denmark.
authors.forename: Søren
authors.initials: S
authors.lastname: Kold
authors.affiliation: p Department of Orthopaedics , Copenhagen University Hospital , Bispebjerg , Denmark.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Krogsgaard
authors.affiliation: q Comparative Medicine Lab, Aarhus University , Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Lauridsen
authors.affiliation: a Orthopaedic Research Laboratory , Aarhus University Hospital , Denmark.
authors.forename: Dang
authors.initials: D
authors.lastname: Le
authors.affiliation: h INSERM UMRS U791, University of Nantes , France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Le Visage
authors.affiliation: b Department of Orthopaedics , Aarhus University Hospital , Denmark.
authors.forename: Martin
authors.initials: M
authors.lastname: Lind
authors.affiliation: r Department of Engineering , Aarhus University , Denmark.
authors.forename: Jens V
authors.initials: JV
authors.lastname: Nygaard
authors.affiliation: a Orthopaedic Research Laboratory , Aarhus University Hospital , Denmark.
authors.forename: Morten L
authors.initials: ML
authors.lastname: Olesen
authors.affiliation: q Comparative Medicine Lab, Aarhus University , Denmark.
authors.forename: Michael
authors.initials: M
authors.lastname: Pedersen
authors.affiliation: p Department of Orthopaedics , Copenhagen University Hospital , Bispebjerg , Denmark.
authors.forename: Martin
authors.initials: M
authors.lastname: Rathcke
authors.affiliation: s Robert Jones and Agnes Hunt Orthopaedic Hospital, Keele University , Oswestry , UK.
authors.forename: James B
authors.initials: JB
authors.lastname: Richardson
authors.affiliation: s Robert Jones and Agnes Hunt Orthopaedic Hospital, Keele University , Oswestry , UK.
authors.forename: Sally
authors.initials: S
authors.lastname: Roberts
authors.affiliation: b Department of Orthopaedics , Aarhus University Hospital , Denmark.
authors.forename: Jan H D
authors.initials: JH
authors.lastname: Rölfing
authors.affiliation: t Department of Orthopaedics , Tokai University Hospital , Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sakai
authors.affiliation: u Faculty of Dentistry , National University of Singapore , Singapore.
authors.forename: Wei Seong
authors.initials: WS
authors.lastname: Toh
authors.affiliation: v Department of Physiology, Anatomy and Genetics , University of Oxford , UK.
authors.forename: Jill
authors.initials: J
authors.lastname: Urban
authors.affiliation: w Department of Orthopaedics , Brigham and Women's Hospital, Harvard Medical School and Tissue Engineering Labs, VA Boston Healthcare System , Boston , MA , USA.
authors.forename: Myron
authors.initials: M
authors.lastname: Spector
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D015897:Comorbidity; D004195:Disease Models, Animal; D006801:Humans; D009141:Musculoskeletal System / Q000503:physiopathology*; D012038:Regeneration / Q000502:physiology; D044968:Regenerative Medicine / Q000379:methods*