title: HNF1B, TSPAN8 and NOTCH2 gene polymorphisms in women with gestational diabetes.
abstract: OBJECTIVE
  To investigate genes involved in pancreatic beta cell function, insulin production and glucose metabolism that may predispose to gestational diabetes mellitus (GDM).
  
  
  METHODS
  The study group consisted of 204 women with GDM and 207 women with normal glucose tolerance (NGT). The following polymorphisms were genotyped for each patient: HNF1B rs4430796, TSPAN8 rs7961581 and NOTCH2 rs10923931. A p value of <.05 was considered to indicate a statistically significant result.
  
  
  RESULTS
  There was a statistically significant increase in the frequency of HNF1B rs4430796 G allele among pregnant women with GDM (GG+AG versus AA, OR: 1.55, 95% CI: 1.01-2.36, p = .042; G versus A, OR: 1.39, 95% CI: 1.06-1.83, p = .018), whereas there were no statistically significant differences in the distributions of TSPAN8 rs7961581 and NOTCH2 rs10923931 genotypes and alleles between women with GDM and healthy pregnant women. In the multivariate logistic regression analysis, older age, higher BMI before pregnancy and a higher number of HNF1B rs4430796 G alleles were independent significant predictors of a higher risk of GDM.
  
  
  CONCLUSIONS
  The results of this study suggest that the HNF1B gene rs4430796 G allele may be associated with increased risk of GDM.
authors.affiliation: a Department of Physiology , Pomeranian Medical University , Szczecin , Poland.
authors.forename: Maciej
authors.identifier: http://orcid.org/0000-0002-3869-5077
authors.initials: M
authors.lastname: Tarnowski
authors.affiliation: a Department of Physiology , Pomeranian Medical University , Szczecin , Poland.
authors.forename: Damian
authors.initials: D
authors.lastname: Malinowski
authors.affiliation: b Department of Biochemistry and Medical Chemistry , Pomeranian Medical University , Szczecin , Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.affiliation: b Department of Biochemistry and Medical Chemistry , Pomeranian Medical University , Szczecin , Poland.
authors.forename: Violetta
authors.initials: V
authors.lastname: Dziedziejko
authors.affiliation: a Department of Physiology , Pomeranian Medical University , Szczecin , Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pawlik
mesh_terms: D000328:Adult; D000367:Age Factors; D000483:Alleles; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005865:Gestational Age; D051539:Hepatocyte Nuclear Factor 1-beta / Q000378:metabolism*; D006801:Humans; D050417:Insulin-Secreting Cells; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D051883:Receptor, Notch2 / Q000378:metabolism; D012189:Retrospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric; D059470:Tetraspanins / Q000378:metabolism
chemical_list: D001786:Blood Glucose; C496495:HNF1B protein, human; C497764:NOTCH2 protein, human; D051883:Receptor, Notch2; C065609:TSPAN8 protein, human; D059470:Tetraspanins; D051539:Hepatocyte Nuclear Factor 1-beta
keywords: Gestational diabetes; HNF1B; NOTCH2; TSPAN8; polymorphism