title: Targeting indolent non-Hodgkin lymphoma.
abstract: Due to recent advancements in the understanding of the molecular pathogenesis of B-cell malignancies, there has been an explosion of innovative agents in development. The purpose of this review is to efficiently summarize novel therapies with activity in indolent non-Hodgkin lymphoma (iNHL) targeting surface antigens, signaling pathways, and the tumor microenvironment. Areas covered: A literature search was performed to identify preclinical data and clinical trials focused on the use of targeted therapies in iNHL subtypes including follicular lymphoma, marginal zone lymphoma, small lymphocytic lymphoma, and lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Classes reviewed include monoclonal antibodies, antibody-drug conjugates, immunomodulatory agents, B-cell receptor pathway inhibitors, Bcl-2 inhibitors, checkpoint inhibitors, chromatin and epigenetic modulating agents, and CAR T-cells. Expert commentary: Opinions regarding strategies to address the prioritization of novel agents entering clinical development, the determination of rational combination therapy, the development of novel endpoints to expedite clinical development, and the movement towards novel consolidative approaches with immuno- and cellular therapy in an attempt to provide curative treatment options are provided. Also, the economic impact of indefinite therapy is discussed.
authors.affiliation: a Lymphoma Division , John Theurer Cancer Center , Hackensack , NJ , USA.
authors.forename: Lori A
authors.initials: LA
authors.lastname: Leslie
authors.affiliation: a Lymphoma Division , John Theurer Cancer Center , Hackensack , NJ , USA.
authors.forename: Alan P
authors.initials: AP
authors.lastname: Skarbnik
authors.affiliation: a Lymphoma Division , John Theurer Cancer Center , Hackensack , NJ , USA.
authors.forename: Coleen
authors.initials: C
authors.lastname: Bejot
authors.affiliation: a Lymphoma Division , John Theurer Cancer Center , Hackensack , NJ , USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Stives
authors.affiliation: a Lymphoma Division , John Theurer Cancer Center , Hackensack , NJ , USA.
authors.forename: Tatyana A
authors.initials: TA
authors.lastname: Feldman
authors.affiliation: a Lymphoma Division , John Theurer Cancer Center , Hackensack , NJ , USA.
authors.forename: Andre H
authors.initials: AH
authors.lastname: Goy
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D003131:Combined Modality Therapy; D044127:Epigenesis, Genetic / Q000187:drug effects; D006801:Humans; D018796:Immunoconjugates / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D007167:Immunotherapy / Q000379:methods; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D058990:Molecular Targeted Therapy; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D018796:Immunoconjugates; D007155:Immunologic Factors; D047428:Protein Kinase Inhibitors; D011947:Receptors, Antigen, B-Cell
keywords: B-cell receptor pathway; Targeted therapy; antibody-drug conjugate; epigenetic; follicular; immunotherapy; lymphoplasmacytic; marginal zone; monoclonal antibody; small lymphocytic lymphoma