title: Injectable Self-Healing Hydrogel with Antimicrobial and Antifouling Properties.
abstract: Microbial adhesion, biofilm formation and associated microbial infection are common challenges faced by implanted biomaterials (e.g., hydrogels) in bioengineering applications. In this work, an injectable self-healing hydrogel with antimicrobial and antifouling properties was prepared through self-assembly of an ABA triblock copolymer employing catechol functionalized polyethylene glycol (PEG) as A block and poly{[2-(methacryloyloxy)-ethyl] trimethylammonium iodide}(PMETA) as B block. This hydrogel exhibits excellent thermosensitivity, and can effectively inhibit the growth of E. coli (>99.8% killing efficiency) and prevent cell attachment. It can also heal autonomously from repeated damage, through mussel-inspired catechol-mediated hydrogen bonding and aromatic interactions, exhibiting great potential in bioengineering applications.
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta , Edmonton, Alberta T6G 1H9, Canada.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta , Edmonton, Alberta T6G 1H9, Canada.|College of Light Industry, Textile & Food Engineering, Sichuan University , Chengdu 610065, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yan
authors.affiliation: Department of Agriculture, Food and Nutritional Science, University of Alberta , Edmonton, Alberta T6G 2P5, Canada.
authors.forename: Jingqi
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Agriculture, Food and Nutritional Science, University of Alberta , Edmonton, Alberta T6G 2P5, Canada.
authors.forename: Weijuan
authors.identifier: http://orcid.org/0000-0002-8655-130X
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Agriculture, Food and Nutritional Science, University of Alberta , Edmonton, Alberta T6G 2P5, Canada.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta , Edmonton, Alberta T6G 1H9, Canada.
authors.forename: Hongbo
authors.identifier: http://orcid.org/0000-0002-1432-5979
authors.initials: H
authors.lastname: Zeng
mesh_terms: D000900:Anti-Bacterial Agents; D004926:Escherichia coli; D020100:Hydrogels / Q000737:chemistry*; D011092:Polyethylene Glycols
chemical_list: D000900:Anti-Bacterial Agents; D020100:Hydrogels; D011092:Polyethylene Glycols
keywords: antifouling; antimicrobial; catechol; hydrogel; self-healing