title: Resistance to antifungal therapies.
abstract: The evolution of antifungal resistance among fungal pathogens has rendered the limited arsenal of antifungal drugs futile. Considering the recent rise in the number of nosocomial fungal infections in immunocompromised patients, the emerging clinical multidrug resistance (MDR) has become a matter of grave concern for medical professionals. Despite advances in therapeutic interventions, it has not yet been possible to devise convincing strategies to combat antifungal resistance. Comprehensive understanding of the molecular mechanisms of antifungal resistance is essential for identification of novel targets that do not promote or delay emergence of drug resistance. The present study discusses features and limitations of the currently available antifungals, mechanisms of antifungal resistance and highlights the emerging therapeutic strategies that could be deployed to combat MDR.
authors.affiliation: Institute of Integrative Sciences and Health and Institute of Biotechnology, Amity University Haryana, Amity Education Valley, Gurgaon, India rprasad@ggn.amity.edu.
authors.forename: Rajendra
authors.initials: R
authors.lastname: Prasad
authors.affiliation: School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
authors.forename: Atanu
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: Department of Bioresources, University of Kashmir, Srinagar, India.
authors.forename: Abdul Haseeb
authors.initials: AH
authors.lastname: Shah
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D025141:Drug Resistance, Fungal / Q000187:drug effects*; D018432:Drug Resistance, Multiple / Q000187:drug effects; D004359:Drug Therapy, Combination; D026901:Membrane Transport Proteins / Q000378:metabolism; D058990:Molecular Targeted Therapy
chemical_list: D000935:Antifungal Agents; D026901:Membrane Transport Proteins
keywords: antifungal drugs; fungal pathogens; multidrug resistance