title: [Perioperative gabapentin and pregabalin in cardiac surgery: a systematic review and meta-analysis].
abstract: OBJECTIVE
  Sternotomy for cardiac surgeries causes significant postoperative pain and when not properly managed may cause significant morbidity. As neuropathic pain is a significant component here, gabapentin and pregabalin may be effective in these patients and may reduce postoperative opioid consumption. The purpose of this systematic review was to find out efficacy of gabapentin and pregabalin in acute postoperative pain after cardiac surgery.
  
  
  METHODS
  Published prospective human randomized clinical trials, which compared preoperative and/or postoperative gabapentin/pregabalin with placebo or no treatment for postoperative pain management after cardiac surgery has been included in this review.
  
  
  RESULTS
  Four RCTs each for gabapentin and pregabalin have been included in this systematic review. Three gabapentin and two pregabalin studies reported decrease in opioid consumption in cardiac surgical patients while one gabapentin and two pregabalin studies did not. Three RCTs each for gabapentin and pregabalin reported lower pain scores both during activity and rest. The drugs are not associated with any significant complications.
  
  
  CONCLUSIONS
  Despite lower pain scores in the postoperative period, there is insufficient evidence to recommend routine use of gabapentin and pregabalin to reduce opioid consumption in the cardiac surgical patients.
authors.affiliation: All India Institute of Medical Sciences, Department of Anaesthesiology & Intensive Care, New Delhi, Índia.
authors.forename: Souvik
authors.initials: S
authors.lastname: Maitra
authors.affiliation: All India Institute of Medical Sciences, Department of Anaesthesiology & Intensive Care, New Delhi, Índia.
authors.forename: Dalim K
authors.initials: DK
authors.lastname: Baidya
authors.affiliation: All India Institute of Medical Sciences, Department of Anaesthesiology & Intensive Care, New Delhi, Índia.
authors.forename: Sulagna
authors.initials: S
authors.lastname: Bhattacharjee
authors.affiliation: All India Institute of Medical Sciences, Department of Anaesthesiology & Intensive Care, New Delhi, Índia. Electronic address: anirbansm@gmail.com.
authors.forename: Anirban
authors.initials: A
authors.lastname: Som
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures / Q000379:methods; D000077206:Gabapentin / Q000627:therapeutic use*; D006801:Humans; D010149:Postoperative Pain / Q000188:drug therapy*; D000069583:Pregabalin / Q000627:therapeutic use*; D056346:Sternotomy; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000069583:Pregabalin; D000077206:Gabapentin
keywords: Cardiac surgery; Cirurgia cardíaca; Dor no pós‐operatório; Gabapentin; Gabapentina; Post‐operative pain; Pregabalin; Pregabalina