title: Iriomoteolides-9a and 11a: two new odd-numbered macrolides from the marine dinoflagellate Amphidinium species.
abstract: Iriomoteolides-9a (1) and 11a (2), new 15- and 19-membered macrolides, respectively, have been isolated from the marine dinoflagellate Amphidinium species (strain KCA09052). Compounds 1 and 2 were obtained from the extracts of the algal cells inoculated in the PES and TKF seawater medium, respectively. The structures of 1 and 2 were assigned on the basis of detailed NMR analyses. Compounds 1 and 2 exhibited cytotoxic activity against human cervix adenocarcinoma HeLa cells.
authors.affiliation: Science Research Center, Kochi University, Nankoku, Kochi, 783-8505, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Kumagai
authors.affiliation: Science Research Center, Kochi University, Nankoku, Kochi, 783-8505, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tsuda
authors.affiliation: Research Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido, 060-8589, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Fukushi
authors.affiliation: Research Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido, 060-8589, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kawabata
authors.affiliation: College of Agriculture, Tamagawa University, Machida, Tokyo, 194-8610, Japan.
authors.forename: Atsunori
authors.initials: A
authors.lastname: Masuda
authors.affiliation: Center for Advanced Marine Core Research and Department of Agriculture and Marine Science, Kochi University, Nankoku, Kochi, 783-8502, Japan. mtsuda@kochi-u.ac.jp.
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsuda
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004141:Dinoflagellida / Q000737:chemistry*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; C000625112:Iriomoteolide 11a; C000625111:Iriomoteolide 9a; D018942:Macrolides
keywords: Amphidinium; Cytotoxic activity; Dinoflagellate; Macrolide