title: MCR-1.6, a New MCR Variant Carried by an IncP Plasmid in a Colistin-Resistant Salmonella enterica Serovar Typhimurium Isolate from a Healthy Individual.
abstract: In this study, we report a novelmcr-1gene variant, namedmcr-1.6, carried by an IncP plasmid in a colistin-resistantSalmonella entericaserovar Typhimurium isolate from a healthy person. Compared withmcr-1, themcr-1.6gene contains two single-nucleotide polymorphisms, one of which results in an arginine to histidine variation (Arg536→His). The plasmid carrying themcr-1.6gene was designated pMCR1.6_P053 and is similar to a recently discoveredmcr-1-bearing plasmid found inKlebsiella pneumoniae.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Yongfei
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Yulin Center for Disease Control and Prevention, Guangxi, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Luo
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
authors.forename: Haijian
authors.initials: H
authors.lastname: Zhou
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.|School of Food and Chemical Engineering, Beijing Technology and Business University, Beijing, China.
authors.forename: Xiaoxun
authors.initials: X
authors.lastname: Wang
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Du
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
authors.forename: Zhenpeng
authors.initials: Z
authors.lastname: Li
authors.affiliation: School of Food and Chemical Engineering, Beijing Technology and Business University, Beijing, China.
authors.forename: Jialiang
authors.initials: J
authors.lastname: Xu
authors.affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China zhubaoli@im.ac.cn xxb72@sina.com kanbiao@icdc.cn.
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China zhubaoli@im.ac.cn xxb72@sina.com kanbiao@icdc.cn.
authors.forename: Xuebin
authors.initials: X
authors.lastname: Xu
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China zhubaoli@im.ac.cn xxb72@sina.com kanbiao@icdc.cn.
authors.forename: Biao
authors.initials: B
authors.lastname: Kan
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D003091:Colistin / Q000494:pharmacology*; D003227:Conjugation, Genetic / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004982:Ethanolaminephosphotransferase / Q000235:genetics*; D005260:Female; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D010957:Plasmids / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D008565:Membrane Proteins; D004982:Ethanolaminephosphotransferase; D003091:Colistin
keywords: IncP plasmid; MCR-1.6; Salmonella enterica serovar Typhimurium; colistin resistance