title: The Autophagy Machinery: A New Player in Chemotactic Cell Migration.
abstract: Autophagy is a highly conserved self-degradative process that plays a key role in diverse cellular processes such as stress response or differentiation. A growing body of work highlights the direct involvement of autophagy in cell migration and cancer metastasis. Specifically, autophagy has been shown to be involved in modulating cell adhesion dynamics as well as epithelial-to-mesenchymal transition. After providing a general overview of the mechanisms controlling autophagosome biogenesis and cell migration, we discuss how chemotactic G protein-coupled receptors, through the repression of autophagy, may orchestrate membrane trafficking and compartmentation of specific proteins at the cell front in order to support the critical steps of directional migration.
authors.affiliation: Normandie Univ, UNIROUEN, Institut National de la Santé et de la Recherche Médicale (INSERM), DC2NRouen, France; Institute for Research and Innovation in BiomedicineRouen, France.
authors.forename: Pierre-Michaël
authors.initials: PM
authors.lastname: Coly
authors.affiliation: Normandie Univ, UNIROUEN, Institut National de la Santé et de la Recherche Médicale (INSERM), DC2NRouen, France; Institute for Research and Innovation in BiomedicineRouen, France.
authors.forename: Pierrick
authors.initials: P
authors.lastname: Gandolfo
authors.affiliation: Normandie Univ, UNIROUEN, Institut National de la Santé et de la Recherche Médicale (INSERM), DC2NRouen, France; Institute for Research and Innovation in BiomedicineRouen, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Castel
authors.affiliation: Normandie Univ, UNIROUEN, Institut National de la Santé et de la Recherche Médicale (INSERM), DC2NRouen, France; Institute for Research and Innovation in BiomedicineRouen, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Morin
keywords: CXCR4; GPCR; autophagosome biogenesis; cell adhesion; chemotactic migration; urotensin II