title: Imaging of Prostate Cancer Using Gallium-68-Labeled Bombesin.
abstract: Nuclear medicine can play an important role in evaluating prostate cancer combining anatomical and functional information with hybrid techniques. Various PET radiopharmaceuticals have been used for targeting specific biological markers in prostate cancer. Research is ideally oriented towards the development of radiopharmaceuticals targeting antigens overexpressed in prostate cancer, as opposed to normal prostate tissue. In this regard, gastrin-releasing peptide receptors (GRPR) are excellent candidates. Bombesin analogues targeting the GRPR have been investigated. Gallium-68 (68Ga) is an interesting PET radioisotope due to several advantages, such as availability, ease of radiochemistry, half-life, and costs. The focus of this review is on68Ga-labeled bombesin analogues in prostate cancer.
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address: isonni@stanford.edu.
authors.forename: Ida
authors.initials: I
authors.lastname: Sonni
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.
authors.forename: Lucia
authors.initials: L
authors.lastname: Baratto
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.
authors.forename: Andrei
authors.initials: A
authors.lastname: Iagaru
mesh_terms: D000954:Antigens, Surface / Q000378:metabolism; D001839:Bombesin; D002250:Carbon Radioisotopes; D002264:Carboxylic Acids; D002794:Choline; D003503:Cyclobutanes; D019788:Fluorodeoxyglucose F18; D005544:Forecasting; D005710:Gallium Radioisotopes; D043425:Glutamate Carboxypeptidase II / Q000378:metabolism; D006801:Humans; D008297:Male; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods / Q000639:trends; D049268:Positron-Emission Tomography / Q000379:methods / Q000639:trends; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D018004:Receptors, Bombesin / Q000378:metabolism
chemical_list: D000954:Antigens, Surface; D002250:Carbon Radioisotopes; D002264:Carboxylic Acids; D003503:Cyclobutanes; D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D018004:Receptors, Bombesin; D019788:Fluorodeoxyglucose F18; C117460:fluciclovine F-18; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II; D002794:Choline; D001839:Bombesin
keywords: Bombesin; Gallium-68; Gastrin-releasing peptide receptor; Imaging; PET; Prostate cancer