title: A nor-diterpene from Salvia sahendica leaves.
abstract: Phytochemical investigation of n-hexane extract of Salvia sahendica by normal phase column chromatography resulted in the isolation of six compounds. Structures were established by 1D and 2D NMR spectroscopy, and HRMS, as a new norditerpene 1, and known terpenoids, sclareol (2), oleanolic acid (3), β-sitosterol (4), salvigenin (5) and 3α-hydroxy-11α,12α-epoxyoleanan-28,13β-olide (6). The absolute configuration of 1 was confirmed by a combination of X-ray single crystal analysis and electronic circular dichroism spectroscopy. In vitro cytotoxic activity on breast cancer cell line (MDA-MB-231) and also the antimicrobial activity of the pure compounds were tested against Staphylococcus aureus, Bacilus cereus and Escherichia coli.
authors.affiliation: a Department of Phytochemistry , Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin , Tehran , Iran.
authors.forename: Sahar
authors.initials: S
authors.lastname: Mofidi Tabatabaei
authors.affiliation: a Department of Phytochemistry , Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin , Tehran , Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Salehi
authors.affiliation: a Department of Phytochemistry , Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin , Tehran , Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Moridi Farimani
authors.affiliation: b Department of Chemistry , University of Basel , Basel , Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Neuburger
authors.affiliation: c Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences , University of Basel , Basel , Switzerland.
authors.forename: Maria
authors.initials: M
authors.lastname: De Mieri
authors.affiliation: c Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences , University of Basel , Basel , Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Hamburger
authors.affiliation: a Department of Phytochemistry , Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin , Tehran , Iran.
authors.forename: Samad
authors.initials: S
authors.lastname: Nejad-Ebrahimi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D005260:Female; D047309:Flavones / Q000737:chemistry; D006586:Hexanes / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*; D012855:Sitosterols / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D047309:Flavones; D006586:Hexanes; D010936:Plant Extracts; D012855:Sitosterols; C014049:salvigenin; C026385:n-hexane; C025473:gamma-sitosterol; D009828:Oleanolic Acid; C070760:sclareol
keywords: ECD; Lamiaceae; Salvia sahendica; norditerpene; structure elucidation