title: Practical Considerations of Fractional Flow Reserve Utilization to Guide Revascularization.
abstract: Invasive angiography has long been the gold standard for the diagnosis of obstructive coronary artery disease (CAD). However, the relationship between angiographic measures of stenosis and coronary blood flow is complex, and there is frequent discordance between the visual assessment of a stenotic lesion and its effect on myocardial perfusion. Fractional flow reserve is a rapidly emerging invasive means of assessing the physiologic significance of an epicardial stenosis. This review provides a pragmatic understanding of the physiologic principles that guide fractional flow reserve (FFR), sheds light on its nuances, and explores the most landmark investigations. We will also discuss how the measurement of FFR can be helpful or limiting in several common clinical situations.
authors.affiliation: Department of Medicine, Greenberg Division of Cardiology, New York Presbyterian Hospital-Weill Cornell Medicine, 520 East 70th Street, Starr-434 Pavilion, New York, NY, 10021, USA. tas2012@nyp.org.
authors.forename: Tara
authors.initials: T
authors.lastname: Shah
authors.affiliation: Department of Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, 525 East 68th Street, New York, NY, 10065, USA.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Geleris
authors.affiliation: Division of Cardiology, Albany Medical Center, 47 New Scotland Ave, MC-44, Albany, NY, 12208, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: Schulman-Marcus
authors.affiliation: Department of Medicine, Greenberg Division of Cardiology, New York Presbyterian Hospital-Weill Cornell Medicine, 520 East 70th Street, Starr-434 Pavilion, New York, NY, 10021, USA.
authors.forename: Dmitriy N
authors.initials: DN
authors.lastname: Feldman
authors.affiliation: Duke Clinical Research Institute, Duke University Medical Center, 508 Fulton Street (A3014), Durham, NC, 27705, USA.
authors.forename: Rajesh V
authors.initials: RV
authors.lastname: Swaminathan
keywords: Coronary artery disease; Fractional flow reserve; Invasive angiography; Stenosis