title: Liposome-targeted delivery for highly potent drugs.
abstract: Considerable adverse side effects and cytotoxicity of highly potent drugs for healthy tissue require the development of novel drug delivery systems to improve pharmacokinetics and result in selective distribution of the loaded agent. The introduction of targeted liposomal formulations has provided potential solutions for improved drug delivery to cancer cells, penetrating delivery through blood-brain barrier and gene therapy. A large number of investigations have been developed over the past few decades to overcome pharmacokinetics and unfavorable side effects limitations. These improvements have enabled targeted liposome to meet criteria for successful and improved potent drug targeting. Promising in vitro and in vivo results for liposomal-directed delivery systems appear to be effective for vast variety of highly potent therapeutics. This review will focus on the past decade's potential use and study of highly potent drugs using targeted liposomes.
authors.affiliation: a Cellular and Molecular Research Center , Yasuj University of Medical Sciences , Yasuj , Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Bardania
authors.affiliation: b Biomedical Division, Faculty of Chemical Engineering , Tarbiat Modares University , Tehran , Iran.
authors.forename: Shabnam
authors.initials: S
authors.lastname: Tarvirdipour
authors.affiliation: c Department of Pharmaceutics, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Iran.|d Medical Biomaterial Research Center (MBRC) , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Farid
authors.initials: F
authors.lastname: Dorkoosh
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004247:DNA / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008081:Liposomes; D011506:Proteins / Q000008:administration & dosage; D012313:RNA / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D011506:Proteins; D012313:RNA; D004247:DNA
keywords: Liposome; highly potent drugs; liposome targeted delivery