title: The mirror RNA expression pattern in human tissues.
abstract: It has been realized in recent years that non-coding RNAs are playing important roles in genome functions and human diseases. Here we developed a new technology and observed a new pattern of gene expression. We observed that over 72% of RNAs in human genome are expressed in forward-reverse pairs, just like mirror images of each other between forward expression and reverse expression; the overview showed that it cannot be simply described as transcript overlapping, so we designated it as mirror expression. Furthermore, we found that the mirror expression is gene-specific and tissue-specific, and less common in the proximal promoter regions. The size of the shadows varies between different genes, different tissues and different classes. The shadow expression is most significant in the Alu element, it was also observed among L1, Simple Repeats and LTR elements, but rare in other repeats such as low-complexity, LINE/L2, DNA and MIRs. Although there is no evidence yet about the relationship of this mirror pattern and double-strand RNA (dsRNA), this new striking pattern provides a new clue and a new direction to unveil the role of RNAs in the genome functions and diseases.
authors.affiliation: Cardiovascular Research Institute and Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia 30310, USA.
authors.forename: Tameka N
authors.initials: TN
authors.lastname: Bythwood
authors.affiliation: Cardiovascular Research Institute and Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia 30310, USA; Center for Big Data Science, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.affiliation: Cardiovascular Research Institute and Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia 30310, USA; Center for Big Data Science, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Li
authors.affiliation: Cardiovascular Research Institute and Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia 30310, USA; 4DGenome Inc, Atlanta, Georgia 30033, USA.
authors.forename: Weinian
authors.initials: W
authors.lastname: Rao
authors.affiliation: Center for Big Data Science, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
authors.forename: Qiling
authors.initials: Q
authors.lastname: Li
authors.affiliation: Center for Big Data Science, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Xue
authors.affiliation: Cardiovascular Research Institute and Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia 30310, USA.
authors.forename: Jendai
authors.initials: J
authors.lastname: Richards
authors.affiliation: Cardiovascular Research Institute and Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia 30310, USA; 4DGenome Inc, Atlanta, Georgia 30033, USA; Center for Big Data Science, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.affiliation: Cardiovascular Research Institute and Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia 30310, USA; 4DGenome Inc, Atlanta, Georgia 30033, USA; Center for Big Data Science, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Song
keywords: Alu; RNA; antisense