title: Susceptiveness of Vitamin K epOxide Reductase Complex Subunit 1 Gene Polymorphism in Essential Hypertension.
abstract: BACKGROUND
  Essential hypertension (EH) is defined as a worldwide public health problem and one of the important risk factors for development of human coronary artery disease. Increased peripheral arterial resistance is one of the distinguishing characteristics of EH. The extracellular deposition of calcium in the arterial wall is defined as vascular calcification, which results in aortic stiffness and elevation of blood pressure. Regulation of vascular calcification is physiologically limited by γ-carboxylated proteins that regulate mineralization. Any deficiencies related to mineralization influence vascular calcification. As a result of vitamin-K deficiency or any problem associated with the vitamin K epOxide reductase complex subunit 1 (VKORC1) gene, Glu cannot be transformed to Gla and calcification initiates in blood vessels, myocardium, and cardiac.
  
  
  OBJECTIVE
  The aim of the study was to investigate the potential association of VKORC1 polymorphisms with the risk of EH.
  
  
  METHODS
  There were 100 individuals diagnosed with EH and 100 healthy individuals involved in the study. 3673G/A (rs9923231) and 9041G/A (rs7294) polymorphisms in the VKORC1 gene were determined by the PCR-restriction fragment length polymorphism method.
  
  
  RESULTS
  A significant difference was found between the rs7294 polymorphisms ratios of the case and control groups, but significant differences weren't found in distribution of the rs9923231 alleles. Finally it was determined that the GG genotype provides a 3.97-fold increased risk for EH compared to the AA genotype for the rs7294 polymorphism.
  
  
  CONCLUSIONS
  Our results suggest that the VKORC1 gene rs7294 polymorphism is important for the development of EH.
authors.affiliation: 1 Department of Medical Biology, Faculty of Medicine, Eskisehir Osmangazi University , Eskisehir, Turkey .
authors.forename: Didem
authors.initials: D
authors.lastname: Turgut Cosan
authors.affiliation: 2 Department of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University , Eskisehir, Turkey .
authors.forename: Huseyin Ugur
authors.initials: HU
authors.lastname: Yazıcı
authors.affiliation: 1 Department of Medical Biology, Faculty of Medicine, Eskisehir Osmangazi University , Eskisehir, Turkey .
authors.forename: Emine
authors.initials: E
authors.lastname: Colak
authors.affiliation: 3 Department of Medical Biology, Faculty of Medicine, Istanbul Aydın University , Istanbul, Turkey .
authors.forename: Ahu
authors.initials: A
authors.lastname: Soyocak
authors.affiliation: 1 Department of Medical Biology, Faculty of Medicine, Eskisehir Osmangazi University , Eskisehir, Turkey .
authors.forename: Irfan
authors.initials: I
authors.lastname: Degirmenci
authors.affiliation: 1 Department of Medical Biology, Faculty of Medicine, Eskisehir Osmangazi University , Eskisehir, Turkey .
authors.forename: Hulyam
authors.initials: H
authors.lastname: Kurt
authors.affiliation: 2 Department of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University , Eskisehir, Turkey .
authors.forename: Alparslan
authors.initials: A
authors.lastname: Birdane
authors.affiliation: 4 Department of Biostatistics, Faculty of Medicine, Eskisehir Osmangazi University , Eskisehir, Turkey .
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Colak
authors.affiliation: 1 Department of Medical Biology, Faculty of Medicine, Eskisehir Osmangazi University , Eskisehir, Turkey .
authors.forename: Hasan Veysi
authors.initials: HV
authors.lastname: Gunes
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics; D000075222:Essential Hypertension / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D061205:Vascular Calcification / Q000235:genetics; D064417:Vitamin K Epoxide Reductases / Q000235:genetics* / Q000378:metabolism
chemical_list: C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases
keywords: VKORC1; essential hypertension; matrix-Gla protein; vascular calcification; vitamin K