title: A new xanthone from the fungus Apiospora montagnei.
abstract: A new xanthone derivative, methyl 8-hydroxy-3-hydroxymethylxanthone-1-carboxylate (1), and seven known compounds, 8-hydroxy-3-methylxanthone-1-carboxylate (2), methyl 8-hydroxy-6-methylxanthone-1-carboxylate (3), ergosterol (4), cyathisterone (5), ergosta-4,6,8(14),22-tetraen-3-one (6), calvasterone (7) and 2-hexyl-3-methylmaleic anhydride (8) were first isolated from the fungus Apiospora montagnei. Their structures were elucidated on the basis of spectroscopic analysis (UV, IR, MS, 1D, and 2D NMR). Compounds 5 and 6 showed weak to very weak cytotoxicity against cancer cell lines, NCI-H187 and KB.
authors.affiliation: a Natural Products Research Unit, Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry , Khon Kaen University , Bangkok , Thailand.|b Chemistry program, Faculty of Science and Technology , Sakon Nakhon Rajabhat University , Sakon Nakhon , Thailand.
authors.forename: Supakorn
authors.initials: S
authors.lastname: Arthan
authors.affiliation: a Natural Products Research Unit, Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry , Khon Kaen University , Bangkok , Thailand.
authors.forename: Cholpisut
authors.initials: C
authors.lastname: Tantapakul
authors.affiliation: a Natural Products Research Unit, Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry , Khon Kaen University , Bangkok , Thailand.
authors.forename: Kwanjai
authors.initials: K
authors.lastname: Kanokmedhakul
authors.affiliation: c Faculty of Agricultural Technology, Department of Plant Production Technology , King Mongkut's Institute of Technology Ladkrabang , Bangkok , Thailand.
authors.forename: Kasem
authors.initials: K
authors.lastname: Soytong
authors.affiliation: a Natural Products Research Unit, Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry , Khon Kaen University , Bangkok , Thailand.
authors.forename: Somdej
authors.initials: S
authors.lastname: Kanokmedhakul
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004875:Ergosterol / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet; D044004:Xanthones / Q000737:chemistry* / Q000494:pharmacology; D013098:Xylariales / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D044004:Xanthones; C000624637:methyl 8-hydroxy-3-hydroxymethylxanthone-1-carboxylate; D004875:Ergosterol
keywords: Apiospora montagnei; cytotoxicity; xanthone