title: Revascularization in a 17-Year-Old Girl with Neurofibromatosis and Severe Hypertension Caused by Renal Artery Stenosis.
abstract: Renal artery stenosis caused by neurofibromatosis is a rare cause of renovascular hypertension. This hypertension can develop during childhood and is one of the leading causes of poor outcome. We report the case of a 17-year-old girl who was incidentally diagnosed with severe hypertension. During her examination for secondary hypertension, we reached a diagnosis of neurofibromatosis type 1 on the basis of a cluster of typical findings: optic nerve glioma, café au lait spots, nodular neurofibromas, and axillary freckling. Renal angiograms revealed a hemodynamically significant left renal artery stenosis (70%). Renal angioplasty with a self-expanding stent was performed one month later for rapidly progressive renal artery stenosis (90%) and uncontrolled blood pressure. Excellent blood pressure control resulted immediately and was maintained as of the 2-year follow-up evaluation. We think that percutaneous transluminal renal angioplasty can be effective in select patients who have neurofibromatosis type 1 and refractory hypertension caused by renal artery stenosis.
authors.forename: Carmen C
authors.initials: CC
authors.lastname: Beladan
authors.forename: Oliviana D
authors.initials: OD
authors.lastname: Geavlete
authors.forename: Simona
authors.initials: S
authors.lastname: Botezatu
authors.forename: Marin
authors.initials: M
authors.lastname: Postu
authors.forename: Bogdan A
authors.initials: BA
authors.lastname: Popescu
authors.forename: Carmen
authors.initials: C
authors.lastname: Ginghina
authors.forename: Ioan M
authors.initials: IM
authors.lastname: Coman
mesh_terms: D000293:Adolescent; D000800:Angioplasty, Balloon / Q000295:instrumentation; D001794:Blood Pressure; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D018810:Magnetic Resonance Angiography; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000175:diagnosis; D011474:Prosthesis Design; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D012079:Renal Circulation; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency
keywords: Blood pressure monitoring, ambulatory/methods; hypertension, renovascular/diagnosis/etiology/radiography/therapy; neurofibromatosis 1/complications/metabolism/pathology; renal artery obstruction/complications/pathology/therapy; treatment outcome; vascular diseases/physiopathology