title: The Asian Perspective on the Surgical and Adjuvant Management of Esophagogastric Cancer.
abstract: In East Asia, D2 dissection has been routine surgical procedure for curable advanced gastric cancer. More extended surgery than D2 is reserved for borderline resectable disease with extended nodal metastasis. The addition of radiation therapy to adjuvant chemotherapy failed to improve the outcome after D2 dissection. Because many patients are diagnosed in East Asia with early-stage disease, postoperative adjuvant chemotherapy is preferred, and S-1 monotherapy or capecitabine-oxaliplatin is standard care. Neoadjuvant chemotherapy may be preferred for stage III tumors; for borderline resectable tumors, preoperative chemotherapy is under study given the limitations of postoperative adjuvant chemotherapy in high-risk patients.
authors.affiliation: Department of Gastrointestinal Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadagaoka, Suita, Osaka Prefecture 565-0871, Japan.
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Kurokawa
authors.affiliation: Department of Multidisciplinary Surgical Oncology, Hyogo College of Medicine, 1-1, Mukogawacho, Nishinomiya, Hyogo Prefecture 663-8501, Japan. Electronic address: msasako@hyo-med.ac.jp.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Sasako
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003841:Deoxycytidine / Q000627:therapeutic use; D013505:Digestive System Surgical Procedures; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D004943:Esophagogastric Junction; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D020360:Neoadjuvant Therapy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D003841:Deoxycytidine; D005472:Fluorouracil
keywords: Adjuvant chemotherapy; D2 dissection; Esophagogastric junctional cancer; Gastric cancer; Multidisciplinary treatment; Neoadjuvant chemotherapy