title: Imaging of Prostate Cancer Using11C-Choline PET/Computed Tomography.
abstract: This article reviews the role of11C-choline-PET/computed tomography (CT) in patients with prostate cancer for diagnosis, staging, and restaging the disease in case of biochemical recurrence after primary treatment. The main application of this imaging procedure is restaging of the disease in case of biochemical recurrence.11C-Choline-PET/CT proved its value for metastases-directed salvage therapies and for monitoring therapy response in castration-resistant patients. Prostate-specific antigen and prostate-specific antigen kinetics values confirmed their correlation with11C-choline PET/CT sensitivity.11C-CholinePET/CT, despite low sensitivity to stage disease or in case of biochemical failure with low PSA levels, has an important impact on the management of patients with prostate cancer.
authors.affiliation: Service of Nuclear Medicine, S. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Castellucci
authors.affiliation: Service of Nuclear Medicine, S. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy. Electronic address: francesco.ceci@studio.unibo.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Ceci
authors.affiliation: Service of Nuclear Medicine, S. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Fanti
mesh_terms: D002250:Carbon Radioisotopes; D002794:Choline; D055088:Early Detection of Cancer / Q000379:methods; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D064129:Prostatic Neoplasms, Castration-Resistant / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D016879:Salvage Therapy; D012680:Sensitivity and Specificity
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D017430:Prostate-Specific Antigen; D002794:Choline
keywords: Choline PET/CT; Diagnosis; Prostate cancer; Staging