title: Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan.
abstract: Balancing the quantity and quality of dietary protein relative to other nutrients is a key determinant of evolutionary fitness. A theoretical framework for defining a balanced diet would both reduce the enormous workload to optimize diets empirically and represent a breakthrough toward tailoring diets to the needs of consumers. Here, we report a simple and powerful in silico technique that uses the genome information of an organism to define its dietary amino acid requirements. We show for the fruit fly Drosophila melanogaster that such "exome-matched" diets are more satiating, enhance growth, and increase reproduction relative to non-matched diets. Thus, early life fitness traits can be enhanced at low levels of dietary amino acids that do not impose a cost to lifespan. Exome matching also enhanced mouse growth, indicating that it can be applied to other organisms whose genome sequence is known.
authors.affiliation: Institute of Healthy Ageing and Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, UK. Electronic address: matthew.piper@monash.edu.
authors.forename: Matthew D W
authors.initials: MDW
authors.lastname: Piper
authors.affiliation: Max Planck Institute for Biology of Ageing, Köln 50931, Germany.
authors.forename: George A
authors.initials: GA
authors.lastname: Soultoukis
authors.affiliation: Berlin Institute of Health, Berlin 10117, Germany.
authors.forename: Eric
authors.initials: E
authors.lastname: Blanc
authors.affiliation: Max Planck Institute for Biology of Ageing, Köln 50931, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Mesaros
authors.affiliation: Behavior and Metabolism Laboratory, Champalimaud Centre for the Unknown, Lisbon 1400-038, Portugal.
authors.forename: Samantha L
authors.initials: SL
authors.lastname: Herbert
authors.affiliation: Max Planck Institute for Biology of Ageing, Köln 50931, Germany.
authors.forename: Paula
authors.initials: P
authors.lastname: Juricic
authors.affiliation: UCL Ear Institute, University College London, London WC1X 8EE, UK.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: He
authors.affiliation: Max Planck Institute for Biology of Ageing, Köln 50931, Germany.
authors.forename: Ilian
authors.initials: I
authors.lastname: Atanassov
authors.affiliation: Max Planck Institute for Biology of Ageing, Köln 50931, Germany.
authors.forename: Hanna
authors.initials: H
authors.lastname: Salmonowicz
authors.affiliation: Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Mingyao
authors.initials: M
authors.lastname: Yang
authors.affiliation: Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney 2050, Australia.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Simpson
authors.affiliation: Behavior and Metabolism Laboratory, Champalimaud Centre for the Unknown, Lisbon 1400-038, Portugal.
authors.forename: Carlos
authors.initials: C
authors.lastname: Ribeiro
authors.affiliation: Institute of Healthy Ageing and Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, UK; Max Planck Institute for Biology of Ageing, Köln 50931, Germany. Electronic address: partridge@age.mpg.de.
authors.forename: Linda
authors.initials: L
authors.lastname: Partridge
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D003198:Computer Simulation; D004044:Dietary Proteins / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D059472:Exome / Q000235:genetics*; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D048788:Growth and Development / Q000187:drug effects*; D008136:Longevity / Q000187:drug effects*; D008810:Mice, Inbred C57BL; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D010063:Ovum / Q000187:drug effects / Q000378:metabolism; D012098:Reproduction / Q000187:drug effects
chemical_list: D000596:Amino Acids; D004044:Dietary Proteins
keywords: Drosophila; amino acids; diet balance; dietary restriction; fitness; growth; lifespan; mouse; reproduction; trade-off