title: Systemic abnormalities associated with retinal vein occlusion in young patients.
abstract: OBJECTIVE
  To study the systemic abnormalities associated with retinal vein occlusion in patients aged ≤50 years with a particular emphasis on atherosclerotic diseases and thrombophilic disorders.
  
  
  METHODS
  Medical charts of patients, aged ≤50 years whose diagnoses were retinal vein occlusions during the period 1995-2015 were retrospectively reviewed. The primary outcome was the number of systemic abnormalities associated with these patients. Secondary outcomes included types of retinal vein occlusion and sites of occlusion.
  
  
  RESULTS
  Atherosclerotic diseases were the most common systemic abnormalities associated with retinal vein occlusion and accounted for 55.1% of the patients in the study. Hypertension in 27.55%, diabetes mellitus in 16.33%, and 5.1% with dyslipidemia were noted. The number of thrombophilic disorders seemed to be less than expected and were noted in only 5.1%. Other systemic abnormalities included viral hepatitis infection, systemic lupus erythematosus, and acquired immunodeficiency syndrome. Oral contraceptives were used by some patients.
  
  
  CONCLUSIONS
  Atherosclerotic diseases remained the most commonly associated systemic diseases in the majority of these patients. Approach to these patients should include a screening for hypertension, diabetes mellitus, and lipid abnormalities. Thrombophilia should also be considered where no obvious atherosclerotic diseases are found or if the patient is <40 years old, a history of thrombosis or a family history of thrombosis is possible.
authors.affiliation: KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Suthasinee
authors.initials: S
authors.lastname: Sinawat
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Nawamindaradhiraj University, Bangkok, Thailand.
authors.forename: Chavisa
authors.initials: C
authors.lastname: Bunyavee
authors.affiliation: KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Tanapat
authors.initials: T
authors.lastname: Ratanapakorn
authors.affiliation: Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Supat
authors.initials: S
authors.lastname: Sinawat
authors.affiliation: KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Wipada
authors.initials: W
authors.lastname: Laovirojjanakul
authors.affiliation: KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Yosanan
authors.initials: Y
authors.lastname: Yospaiboon
keywords: retinal vein occlusion; systemic diseases; young patients