title: Electrochemical Skin Conductance May Be Used to Screen for Diabetic Cardiac Autonomic Neuropathy in a Chinese Population with Diabetes.
abstract: Aims. This study aimed to assess whether the electrochemical skin conductance (ESC) could be used to screen for diabetic cardiac autonomic neuropathy (DCAN) in a Chinese population with diabetes.Methods. We recruited 75 patients with type 2 diabetes mellitus (T2DM) and 45 controls without diabetes. DCAN was diagnosed by the cardiovascular autonomic reflex tests (CARTs) as gold standard. In all subjects ESCs of hands and feet were also detected by SUDOSCAN™ as a new screening method. The efficacy was assessed by receiver operating characteristic (ROC) curve analysis.Results. The ESCs of both hands and feet were significantly lower in T2DM patients with DCAN than those without DCAN (67.33 ± 15.37 versus 78.03 ± 13.73,P= 0.002, and 57.77 ± 20.99 versus 75.03 ± 11.41,P< 0.001). The ROC curve analysis showed the areas under the ROC curve were both 0.75 for ESCs of hands and feet in screening DCAN. And the optimal cut-off values of ESCs, sensitivities, and specificities were 76μS, 76.7%, and 75.6% for hands and 75μS, 80.0%, and 60.0% for feet, respectively.Conclusions. ESC measurement is a reliable and feasible method to screen DCAN in the Chinese population with diabetes before further diagnosis with CARTs.
authors.affiliation: Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Tianyi
authors.initials: T
authors.lastname: He
authors.affiliation: Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Anju
authors.initials: A
authors.lastname: Zuo
authors.affiliation: Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Ruxing
authors.identifier: 0000-0002-8893-1007
authors.initials: R
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China; Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Li
authors.identifier: 0000-0001-7670-8062
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China; Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Xinguo
authors.identifier: 0000-0003-2045-1290
authors.initials: X
authors.lastname: Hou
mesh_terms: D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity