title: Biocompatible hyperbranched polyester magnetic nanocarrier for stimuli-responsive drug release.
abstract: A novel biocompatible magnetic nanocomposite drug carrier was developed by first chemically modifying a hyperbranched polyester (HBPE) with dodecenyl succinic anhydride (DDSA) functional groups to produce HBPE-DDSA. The magnetic nanocomposite Fe3O4/HBPE-DDSA was then synthesized by dispersing superparamagnetic iron oxide (Fe3O4) nanoparticles within HBPE-DDSA. The structure and magnetic properties of the nanocomposite were characterized by1H NMR, MALDI-MS, XRD, FTIR, TEM, and SQUID analyses. Isoniazid (INH) was selected as a model antituberculosis drug to investigate the in vitro drug release properties of Fe3O4/HBPE-DDSA/INH. The cytotoxicity of the magnetic nanocomposites was assessed by CCK-8 assay. The results indicated that Fe3O4/HBPE-DDSA is a promising potential drug carrier for a magnetic-targeted drug delivery system.
authors.affiliation: a School of Chemistry and Materials Science , Nanjing Normal University , Nanjing , China.
authors.forename: Chili
authors.initials: C
authors.lastname: Zhao
authors.affiliation: a School of Chemistry and Materials Science , Nanjing Normal University , Nanjing , China.
authors.forename: Qiaorong
authors.initials: Q
authors.lastname: Han
authors.affiliation: a School of Chemistry and Materials Science , Nanjing Normal University , Nanjing , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Qin
authors.affiliation: b Nanjing Chest Hospital , Nanjing , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yan
authors.affiliation: b Nanjing Chest Hospital , Nanjing , China.
authors.forename: Zhilei
authors.initials: Z
authors.lastname: Qian
authors.affiliation: a School of Chemistry and Materials Science , Nanjing Normal University , Nanjing , China.
authors.forename: Zhenye
authors.initials: Z
authors.lastname: Ma
authors.affiliation: b Nanjing Chest Hospital , Nanjing , China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: a School of Chemistry and Materials Science , Nanjing Normal University , Nanjing , China.
authors.forename: Xinghui
authors.initials: X
authors.lastname: Li
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D065546:Drug Liberation; D007538:Isoniazid / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry*; D013387:Succinic Anhydrides / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D011091:Polyesters; D013387:Succinic Anhydrides; C031801:succinic anhydride; D007538:Isoniazid
keywords: Hyperbranched polyester; biocompatibility; magnetic nanocomposites; magnetic targeted drug delivery system (MTDs)