title: Diagnosis and treatment of cystic lung disease.
abstract: Cystic lung disease (CLD) is a group of lung disorders characterized by the presence of multiple cysts, defined as air-filled lucencies or low-attenuating areas, bordered by a thin wall (usually < 2 mm). The recognition of CLDs has increased with the widespread use of computed tomography. This article addresses the mechanisms of cyst formation and the diagnostic approaches to CLDs. A number of assessment methods that can be used to confirm CLDs are discussed, including high-resolution computed tomography, pathologic approaches, and genetic/ serologic markers, together with treatment modalities, including new therapeutic drugs currently being evaluated. The CLDs covered by this review are lymphangioleiomyomatosis, pulmonary Langerhans cell histiocytosis, Birt-Hogg-Dube syndrome, lymphocytic interstitial pneumonia/follicular bronchiolitis, and amyloidosis.
authors.affiliation: Paju SOK Internal Medical Clinic, Paju, Korea.
authors.forename: Sanghoon
authors.initials: S
authors.lastname: Park
authors.affiliation: Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Lee
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis; D058249:Birt-Hogg-Dube Syndrome / Q000175:diagnosis; D003560:Cysts / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D017563:Lung Diseases, Interstitial / Q000175:diagnosis; D008175:Lung Neoplasms / Q000175:diagnosis; D018192:Lymphangioleiomyomatosis / Q000175:diagnosis
keywords: Birt-Hogg-Dube syndrome; Cystic lung disease; Histiocytosis, Langerhans-cell; Lymphangioleiomyomatosis