title: Dynamics of cortical dendritic membrane potential and spikes in freely behaving rats.
abstract: Neural activity in vivo is primarily measured using extracellular somatic spikes, which provide limited information about neural computation. Hence, it is necessary to record from neuronal dendrites, which can generate dendritic action potentials (DAPs) in vitro, which can profoundly influence neural computation and plasticity. We measured neocortical sub- and suprathreshold dendritic membrane potential (DMP) from putative distal-most dendrites using tetrodes in freely behaving rats over multiple days with a high degree of stability and submillisecond temporal resolution. DAP firing rates were several-fold larger than somatic rates. DAP rates were also modulated by subthreshold DMP fluctuations, which were far larger than DAP amplitude, indicating hybrid, analog-digital coding in the dendrites. Parietal DAP and DMP exhibited egocentric spatial maps comparable to pyramidal neurons. These results have important implications for neural coding and plasticity.
authors.affiliation: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. jason.moore@ucla.edu mayankmehta@ucla.edu.|Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Jason J
authors.identifier: http://orcid.org/0000-0002-4209-3896
authors.initials: JJ
authors.lastname: Moore
authors.affiliation: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.|Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Pascal M
authors.identifier: http://orcid.org/0000-0002-7500-3623
authors.initials: PM
authors.lastname: Ravassard
authors.affiliation: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.|Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: David
authors.initials: D
authors.lastname: Ho
authors.affiliation: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.|Biomedical Engineering Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Lavanya
authors.identifier: http://orcid.org/0000-0003-2419-5650
authors.initials: L
authors.lastname: Acharya
authors.affiliation: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.|Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Ashley L
authors.identifier: http://orcid.org/0000-0002-1611-2803
authors.initials: AL
authors.lastname: Kees
authors.affiliation: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.|Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Cliff
authors.initials: C
authors.lastname: Vuong
authors.affiliation: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. jason.moore@ucla.edu mayankmehta@ucla.edu.|Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.|Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, CA 90095, USA.|Departments of Neurology and Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Mayank R
authors.identifier: http://orcid.org/0000-0003-2005-2468
authors.initials: MR
authors.lastname: Mehta
mesh_terms: D000200:Action Potentials; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D003712:Dendrites / Q000502:physiology*; D004567:Electrodes, Implanted; D008297:Male; D008564:Membrane Potentials; D009457:Neuroglia / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D020332:Rats, Inbred LEC; D012890:Sleep / Q000502:physiology