title: Driving cancer evolution.
abstract: Tumor-growth-factor-beta signaling helps cancer cells to evolve and become resistant to drugs by down-regulating accurate DNA repair.
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.|Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States.|Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, United States.|Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States.
authors.forename: Devon M
authors.identifier: 0000-0002-2480-7269
authors.initials: DM
authors.lastname: Fitzgerald
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.|Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States.|Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, United States.|Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States.
authors.forename: Susan M
authors.identifier: 0000-0003-1444-473X
authors.initials: SM
authors.lastname: Rosenberg
mesh_terms: D051927:CD24 Antigen; D004247:DNA; D004260:DNA Repair; D014644:Genetic Variation; D006801:Humans; D018960:Hyaluronan Receptors; D009369:Neoplasms; D016212:Transforming Growth Factor beta
chemical_list: D051927:CD24 Antigen; C497889:CD24 protein, human; C497483:CD44 protein, human; D018960:Hyaluronan Receptors; D016212:Transforming Growth Factor beta; D004247:DNA
keywords: cancer biology; cell biology; copy number alteration; drug adaptability; genetic diversity; human; intra-tumor heterogeneity; tumor evolution; tumor fitness