title: Who is the real 12-HETrE?
abstract: Oxygenases, including lipoxygenases and cytochrome P450s, generate an array of structurally diverse oxylipins that modulate distinct biological responses in mammals. Depending on the source of tissues and enzymes, distinct oxylipins are generated with inherent cellular function. Here, we report structurally different forms of 12-HETrE, with distinct biological function in tissues as well as their derived enzymatic source.
authors.affiliation: Department of Pharmacology, University of Michigan, Ann Arbor, MI, United States.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Yeung
authors.affiliation: Department of Pharmacology, University of Michigan, Ann Arbor, MI, United States; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, United States. Electronic address: mholinst@umich.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Holinstat
mesh_terms: D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006801:Humans; D058945:Lipoxygenases / Q000378:metabolism
chemical_list: C000620299:12-hydroxy-8,10,14-eicosatrienoic acid; D003577:Cytochrome P-450 Enzyme System; D058945:Lipoxygenases; D015126:8,11,14-Eicosatrienoic Acid
keywords: 12(R)-HETrE; 12(S)-HETrE; Arachidonic acid; Dihomo-gamma-linolenic acid; Platelet 12-LOX; Thrombosis