title: The study of the relationship between aberrant expression of hot shock protein 70 (HSP70) and spontaneous abortion.
abstract: The present study is aimed to explore the relationship between aberrant expression of heat shock protein 70 (HSP) and spontaneous abortion.
  
  
  
  50 patients with spontaneous abortion and 50 patients with induced abortion were continuously selected based on the nearest matching principle, and the proportion of age and gestational age was 1:1. The decidual tissues were obtained, and the cell apoptosis was determined by TUNEL assay. Further, the expression of HSP70 was assayed by immune-histochemical staining, and the expression of HSP70 mRNA was detected by the RT-PCR approach.
  
  
  
  Apoptosis rate, HSP70 expression and HSP70 mRNA expression in the observation group were significantly higher than the control group.
  
  
  
  HSP70 might induce apoptosis so as to cause spontaneous abortion.
authors.affiliation: Medical College of Nanchang University, Nanchang, Jiangxi, P.R. China. huai_liu1@163.com.
authors.forename: Y-B
authors.initials: YB
authors.lastname: Peng
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: S-H
authors.initials: SH
authors.lastname: Huang
authors.forename: H
authors.initials: H
authors.lastname: Lai
authors.forename: Q
authors.initials: Q
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Luo
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Zhang
authors.forename: B-R
authors.initials: BR
authors.lastname: Xi
authors.forename: X
authors.initials: X
authors.lastname: Ouyang
mesh_terms: D000028:Abortion, Induced; D000022:Abortion, Spontaneous / Q000378:metabolism*; D000328:Adult; D017209:Apoptosis; D003656:Decidua / Q000166:cytology / Q000378:metabolism; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics; D055815:Young Adult
chemical_list: D018840:HSP70 Heat-Shock Proteins; D012333:RNA, Messenger