title: Association between the interleukin-1β C-511T polymorphism and periodontitis: a meta-analysis in the Chinese population.
abstract: The association between the interleukin-1 beta (IL-1β) C-511T (or rs16944) polymorphism and periodontitis remains inconclusive, even though there have been previous studies on this association. To assess the effects of IL-1β C-511T variants on the risk of development of periodontitis, a meta-analysis was performed in a single ethnic population. Studies, published up to December 2015, were selected for the meta-analysis from PubMed and Chinese databases. The associations were assessed with pooled OR and 95%CI. This meta-analysis identified 8 studies, including 1276 periodontitis cases and 1558 controls. Overall, a significant association between the IL-1β C-511T polymorphism and periodontitis was found in the Chinese population (TT vs CC: OR = 1.48, 95%CI = 1.19-1.85; TT + CT vs CC: OR = 1.50, 95%CI = 1.25-1.81; T vs C: OR = 1.33, 95%CI = 1.06-1.68). In the subgroup analyses based on geographical area(s), source of controls, and type of periodontitis, significant results were obtained for the association between IL-1β C-511T variants and periodontitis. Our meta-analysis indicated that the IL-1β C-511T polymorphism may be a genetic susceptibility factor for periodontitis in the Chinese population. This marker could be used to identify Chinese individuals at a high risk for periodontitis.
authors.affiliation: Department of Oral Medicine, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: H F
authors.initials: HF
authors.lastname: Wang
authors.affiliation: Department of Prosthodontics, Changsha Stomatological Hospital, Changsha, China.
authors.forename: F Q
authors.initials: FQ
authors.lastname: He
authors.affiliation: Department of Oral Medicine, Xiangya Hospital, Central South University, Changsha, China xyxucj77@126.com.
authors.forename: C J
authors.initials: CJ
authors.lastname: Xu
authors.affiliation: Department of Oral Medicine, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: D M
authors.initials: DM
authors.lastname: Li
authors.affiliation: Department of Oral Medicine, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Sun
authors.affiliation: Department of Oral Medicine, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Y T
authors.initials: YT
authors.lastname: Chi
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: W
authors.initials: W
authors.lastname: Guo
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D015810:Linkage Disequilibrium; D016017:Odds Ratio; D010518:Periodontitis / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D053583:Interleukin-1beta