title: A double-sided fabrication process for intrafascicular parylene C based electrode arrays.
abstract: After the development of a single-sided fabrication process for intrafascicular parylene C based electrode arrays tests showed that an increase in integration density can only be achieved by a double-side process. The process uses 25 μm thick platinum iridium foil, which is thinned down with the laser and sandwiched between two 10 μm thick parylene C layers. Utilizing a picosecond laser (355 nm Nd:YVO4) it was possible to fabricate 40 μm thick electrodes that can be implanted directly in the nerve without relying on additional support layers like chitosan or silk. The fabricated samples feature three 80 μm diameter electrodes on each side and a large ground electrode that is opened to both sides. Impedance mismatches from front to back side as a result of the fabrication process are compensated by electrochemical deposition of nanostructured platinum. This step makes it possible to bring the impedances of the small electrodes down to the range of just a few kΩ at 1 kHz and illustrate the additionally gained surface due to the picosecond laser ablation on the front side electrodes. The safely injectable charge per pulse was found to be 635.75 μC/cm2 for such coated electrodes. Optical investigations show that this fabrication process offers an alternative to established lithographic processes for thin and flexible electrode arrays in neural implants.
authors.forename: M
authors.initials: M
authors.lastname: Mueller
authors.forename: C
authors.initials: C
authors.lastname: Boehler
authors.forename: J
authors.initials: J
authors.lastname: Jaeger
authors.forename: M
authors.initials: M
authors.lastname: Asplund
authors.forename: T
authors.initials: T
authors.lastname: Stieglitz
mesh_terms: D017097:Electric Impedance; D004567:Electrodes, Implanted; D004867:Equipment Design; D005240:Feasibility Studies; D006801:Humans; D007495:Iridium / Q000737:chemistry; D007834:Lasers; D008839:Microelectrodes; D008962:Models, Theoretical; D009474:Neurons / Q000502:physiology; D010984:Platinum / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D014992:Xylenes / Q000737:chemistry*
chemical_list: D011108:Polymers; D014992:Xylenes; C011055:parylene; D007495:Iridium; D010984:Platinum