title: Good response of an aggressive rare variant of signet ring cell carcinoma of prostate with hormonal therapy.
abstract: Primary signet ring cell carcinoma (SRCC) of the prostate is a rare entity, characterised by its aggressive nature and dismal prognosis. We report a case of an advanced SRCC of the prostate presenting as a large pelvic mass with obstructive uropathy and rectal involvement managed by complete androgen blockade. At 24 months follow-up, the patient has no evidence of progression or metastasis. Aggressive management with multimodality approach combining surgery, radiation and hormonal ablation can result in long disease-free survival in some patients, despite the aggressive nature of this disease.
authors.affiliation: All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Deviprasad
authors.initials: D
authors.lastname: Tiwari
authors.affiliation: All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Brusabhanu
authors.initials: B
authors.lastname: Nayak
authors.affiliation: All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Amlesh
authors.initials: A
authors.lastname: Seth
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use*; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists