title: [Expressions and clinical significance of TGF-βRII and NF-κB in oral squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the expression of nuclear factor κappa-B (NF-κB) and transforming growth factor β receptor II (TGF-βRII) and their clinical pathological significance in oral squamous cell carcinoma(OSCC).
  
  
  METHODS
  The expression of NF-κB and TGF-βRII in 60 OSCC samples, 20 adjacent tissues, 29 metastatic lymph nodes and 10 non-metastatic lymph nodes were detected by immunohistological method. Statistical analysis was performed with SPSS 20.0 software package.
  
  
  RESULTS
  The expression of NF-κB in OSCC and metastatic lymph nodes was significantly higher than that in the adjacent tissues and non-metastatic lymph nodes, respectively (P<0.05). However, the expression of TGF-βRII in OSCC and metastatic lymph nodes was significantly lower than that in the adjacent tissues and non-metastatic lymph nodes, respectively (P<0.05). NF-κB was negatively correlated with TGF-βRII. The expression of NF-κB in patients with lower differentiation, lymphatic metastasis and higher grade were significantly higher than in patients with higher differentiation, lower grade and without lymphatic metastasis (P<0.05), respectively. NF-κB was a predicator of OSCC.
  
  
  CONCLUSIONS
  NF-κB is negatively correlated with TGF-βRII.NF-κB and TGF-βRII are associated with the progression of OSCC. NF-κB may promote angiogenesis through down-regulating the expression of TGF-βRII, which promotes progression of OSCC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Stomatology, Chongqing Medical University; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education. Chongqing 401147, China. E-mail:953119965@qq.com.
authors.forename: Li-Lan
authors.initials: LL
authors.lastname: Jiang
authors.forename: Ya-Jun
authors.initials: YJ
authors.lastname: Zhao
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism*; D002454:Cell Differentiation; D015536:Down-Regulation; D006801:Humans; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D016328:NF-kappa B; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D016212:Transforming Growth Factor beta
chemical_list: D016328:NF-kappa B; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II