title: Hetereogeneity in Neuronal Intrinsic Properties: A Possible Mechanism for Hub-Like Properties of the Rat Anterior Cingulate Cortex during Network Activity.
abstract: The anterior cingulate cortex (ACC) is vital for a range of brain functions requiring cognitive control and has highly divergent inputs and outputs, thus manifesting as a hub in connectomic analyses. Studies show diverse functional interactions within the ACC are associated with network oscillations in the β (20-30 Hz) and γ (30-80 Hz) frequency range. Oscillations permit dynamic routing of information within cortex, a function that depends on bandpass filter-like behavior to selectively respond to specific inputs. However, a putative hub region such as ACC needs to be able to combine inputs from multiple sources rather than select a single input at the expense of others. To address this potential functional dichotomy, we modeled local ACC network dynamics in the rat in vitro. Modal peak oscillation frequencies in the β- and γ-frequency band corresponded to GABAAergic synaptic kinetics as seen in other regions; however, the intrinsic properties of ACC principal neurons were highly diverse. Computational modeling predicted that this neuronal response diversity broadened the bandwidth for filtering rhythmic inputs and supported combination-rather than selection-of different frequencies within the canonical γ and β electroencephalograph bands. These findings suggest that oscillating neuronal populations can support either response selection (routing) or combination, depending on the interplay between the kinetics of synaptic inhibition and the degree of heterogeneity of principal cell intrinsic conductances.
authors.affiliation: Institute of Neuroscience, Medical School, Newcastle University, Newcastle-upon-Tyne, NE2 4HH, UK; Department of Mathematics and Statistics, Boston University, Boston, MA 02215.
authors.forename: Natalie E
authors.identifier: 0000-0003-2228-6727
authors.initials: NE
authors.lastname: Adams
authors.affiliation: Department of Mathematics and Statistics, Boston University, Boston, MA 02215; Center for Computational Neuroscience and Neural Technology, Boston University, Boston, MA 02215.
authors.forename: Jason S
authors.identifier: 0000-0001-8467-0025
authors.initials: JS
authors.lastname: Sherfey
authors.affiliation: Department of Mathematics and Statistics, Boston University , Boston, MA 02215.
authors.forename: Nancy J
authors.identifier: 0000-0002-8568-8750
authors.initials: NJ
authors.lastname: Kopell
authors.affiliation: Department of Biology-F1, Hull York Medical School, York University , Heslington, YO10 5DD, UK.
authors.forename: Miles A
authors.identifier: 0000-0002-0247-1362
authors.initials: MA
authors.lastname: Whittington
authors.affiliation: Institute of Neuroscience, Medical School, Newcastle University , Newcastle-upon-Tyne, NE2 4HH, UK.
authors.forename: Fiona E N
authors.identifier: 0000-0003-1453-4022
authors.initials: FE
authors.lastname: LeBeau
mesh_terms: D000818:Animals; D001611:Beta Rhythm / Q000502:physiology*; D016000:Cluster Analysis; D003198:Computer Simulation; D065818:Gamma Rhythm / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism; D006179:Gyrus Cinguli / Q000502:physiology*; D053444:Inhibitory Postsynaptic Potentials / Q000502:physiology; D008297:Male; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism; D018092:Kainic Acid Receptors / Q000378:metabolism; D046509:Tissue Culture Techniques
chemical_list: D018698:Glutamic Acid; D011963:Receptors, GABA-A; D018092:Kainic Acid Receptors
keywords: anterior cingulate; dynamic routing; intrinsic properties; modeling; network oscillations