title: Increased subsequent risk of inflammatory bowel disease association in patients with chronic pancreatitis: a nationwide population-based cohort study.
abstract: To investigate the relationship between chronic pancreatitis (CP) and inflammatory bowel disease (IBD) in a large population-based cohort study.
  
  
  
  Data was obtained from the Taiwan National Health Insurance Research Database. The cohort study comprised 17,796 patients newly diagnosed with CP between 2000 and 2010 and 71,164 matched controls. A Cox proportional hazards model was used for evaluating the risk of IBD in the CP and comparison cohorts.
  
  
  
  When examined with a mean follow-up period of 4.87 and 6.04 years for the CP and comparison cohorts, respectively, the overall incidence of IBD was 10.3 times higher in the CP cohort than in the comparison cohort (5.75 vs. 0.56 per 10,000 person-years). Compared with the comparison cohort, the CP cohort exhibited a higher risk of IBD, irrespective of age, sex, and presence or absence of comorbidities. Moreover, the CP cohort was associated with a significantly higher risk of Crohn's disease (adjusted hazard ratio [aHR] = 12.9, 95% confidence interval [CI] = 5.15-32.5) and ulcerative colitis (aHR = 2.80, 95% CI = 1.00-7.86).
  
  
  
  This nationwide population-based cohort study revealed a significantly higher risk of IBD in patients with CP compared with control group. Clinicians should notice this association to avoid delayed diagnosis of IBD in patients with CP.
authors.affiliation: a Department of Emergency Medicine , Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation , Taipei , Taiwan.|e Department of Emergency Medicine, School of Medicine , Tzu Chi University , Taipei , Taiwan.
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Chen
authors.affiliation: b Department of Emergency Medicine, School of Medicine, College of Medicine , Taipei Medical University , Taipei , Taiwan.|c Department of Emergency and Critical Medicine , Wan Fang Hospital, Taipei Medical University , Taipei , Taiwan.
authors.forename: Chin-Wang
authors.initials: CW
authors.lastname: Hsu
authors.affiliation: d Division of Cardiology, Department of Medicine , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan.
authors.forename: Cheng-Chung
authors.initials: CC
authors.lastname: Cheng
authors.affiliation: a Department of Emergency Medicine , Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation , Taipei , Taiwan.|e Department of Emergency Medicine, School of Medicine , Tzu Chi University , Taipei , Taiwan.
authors.forename: Giou-Teng
authors.initials: GT
authors.lastname: Yiang
authors.affiliation: d Division of Cardiology, Department of Medicine , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan.
authors.forename: Chin-Sheng
authors.initials: CS
authors.lastname: Lin
authors.affiliation: f Management Office for Health Data, China Medical University Hospital , Taichung , Taiwan.|g College of Medicine , China Medical University , Taichung , Taiwan.
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Lin
authors.affiliation: h Department of Health Services Administration , China Medical University , Taichung , Taiwan.|i Faculty of Public Health , Mahidol University , Bangkok , Thailand.
authors.forename: Fung-Chang
authors.initials: FC
authors.lastname: Sung
authors.affiliation: j Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine , China Medical University , Taichung , Taiwan.|k Department of Radiation Oncology , China Medical University Hospital , Taichung , Taiwan.
authors.forename: Ji-An
authors.initials: JA
authors.lastname: Liang
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000150:complications / Q000453:epidemiology*; D015897:Comorbidity; D003424:Crohn Disease / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D050500:Pancreatitis, Chronic / Q000150:complications / Q000453:epidemiology*; D016016:Proportional Hazards Models; D012307:Risk Factors; D013624:Taiwan; D055815:Young Adult
keywords: Chronic pancreatitis; Crohn’s disease; Inflammatory bowel disease; Taiwan National Health Insurance Research Database; Ulcerative colitis