title: One-Pot, Three-Component Assembly of Indoloquinolines: Total Synthesis of Isocryptolepine.
abstract: Indolo[3,2-c]quinolones have been efficiently synthesized via an acid-mediated, one-pot, three-component condensation of arylhydrazines, o-aminoacetophenones, and triazines or nitriles. The synthetic application of this method is showcased by the concise synthesis of isocryptolepine alkaloid and a series of its synthetic analogues with demonstrated cancer cell antiproliferative activities.
authors.affiliation: Department of Chemistry, North Caucasus Federal University , 1a Pushkin Street, Stavropol 355009, Russia.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Aksenov
authors.affiliation: Department of Chemistry, North Caucasus Federal University , 1a Pushkin Street, Stavropol 355009, Russia.
authors.forename: Dmitrii A
authors.initials: DA
authors.lastname: Aksenov
authors.affiliation: Department of Chemistry, North Caucasus Federal University , 1a Pushkin Street, Stavropol 355009, Russia.
authors.forename: Naila A
authors.initials: NA
authors.lastname: Orazova
authors.affiliation: Department of Chemistry, North Caucasus Federal University , 1a Pushkin Street, Stavropol 355009, Russia.
authors.forename: Nicolai A
authors.initials: NA
authors.lastname: Aksenov
authors.affiliation: Department of Chemistry, North Caucasus Federal University , 1a Pushkin Street, Stavropol 355009, Russia.
authors.forename: Georgii D
authors.initials: GD
authors.lastname: Griaznov
authors.affiliation: Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles , Brussels, Belgium.
authors.forename: Annelise
authors.initials: A
authors.lastname: De Carvalho
authors.affiliation: Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles , Brussels, Belgium.
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss
authors.affiliation: Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles , Brussels, Belgium.
authors.forename: Véronique
authors.initials: V
authors.lastname: Mathieu
authors.affiliation: Department of Chemistry and Biochemistry, Texas State University , San Marcos, Texas 78666, United States.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kornienko
authors.affiliation: Department of Chemistry, North Caucasus Federal University , 1a Pushkin Street, Stavropol 355009, Russia.|Department of Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States.
authors.forename: Michael
authors.identifier: 0000-0002-1668-9311
authors.initials: M
authors.lastname: Rubin
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013057:Spectrum Analysis / Q000379:methods; D014227:Triazines / Q000737:chemistry
chemical_list: D026121:Indole Alkaloids; D011804:Quinolines; D014227:Triazines; C577868:isocryptolepine