title: Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits.
abstract: Purpose.This study evaluated the effect of administering intermittent parathyroid hormone [PTH (1-34), henceforth PTH] on the early-stage bone healing of maxillary sinus augmentation in healthy rabbits.Materials and Methods.Bovine bone mineral was grafted on the sinuses of 20 female New Zealand white rabbits. The animals were randomly divided into two groups, PTH (n= 10) or saline (n= 10), in which either PTH or saline was injected subcutaneously 5 days a week for 2 weeks. Half of the animals in each group were killed at 2 weeks postoperatively and the other half were killed at 4 weeks postoperatively. The dosage of PTH was 10μg/kg/day. Radiographic and histomorphometric analyses were performed.Result.The new bone area (NBA) did not differ significantly between the PTH and saline groups. The NBA in the PTH group in the total augmented area and in the demarcated window, center, and Schneiderian membrane regions increased significantly from 2 to 4 weeks. The number of osteoclasts decreased significantly from 2 to 4 weeks in both groups, with no difference between the two groups.Conclusion.Intermittent PTH might not stimulate new bone formation in healthy rabbits during the first 4 weeks of healing.
authors.affiliation: Department of Advanced General Dentistry, College of Dentistry, Yonsei University, Seoul, Republic of Korea.
authors.forename: Jisun
authors.initials: J
authors.lastname: Huh
authors.affiliation: Department of Periodontology, College of Dentistry, Yonsei University, Seoul, Republic of Korea.
authors.forename: Ui-Won
authors.identifier: 0000-0001-6371-4172
authors.initials: UW
authors.lastname: Jung
authors.affiliation: Department of Advanced General Dentistry, College of Dentistry, Yonsei University, Seoul, Republic of Korea.
authors.forename: Kyeong-Mee
authors.initials: KM
authors.lastname: Park
authors.affiliation: Department of Oral Pathology, College of Dentistry, Yonsei University, Seoul, Republic of Korea.
authors.forename: Hyun Sil
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Advanced General Dentistry, College of Dentistry, Yonsei University, Seoul, Republic of Korea.
authors.forename: Kee-Deog
authors.initials: KD
authors.lastname: Kim
authors.affiliation: Department of Advanced General Dentistry, College of Dentistry, Yonsei University, Seoul, Republic of Korea.
authors.forename: Wonse
authors.identifier: 0000-0002-2081-1156
authors.initials: W
authors.lastname: Park
mesh_terms: D000818:Animals; D002417:Cattle; D002452:Cell Count; D005260:Female; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D009297:Nasal Mucosa / Q000601:surgery; D009929:Organ Size; D010010:Osteoclasts / Q000473:pathology; D010281:Parathyroid Hormone / Q000494:pharmacology*; D011817:Rabbits; D059546:Sinus Floor Augmentation / Q000379:methods*; D014945:Wound Healing / Q000187:drug effects*; D055114:X-Ray Microtomography
chemical_list: D010281:Parathyroid Hormone