title: Longitudinal segmentation of age-related white matter hyperintensities.
abstract: Although white matter hyperintensities evolve in the course of ageing, few solutions exist to consider the lesion segmentation problem longitudinally. Based on an existing automatic lesion segmentation algorithm, a longitudinal extension is proposed. For evaluation purposes, a longitudinal lesion simulator is created allowing for the comparison between the longitudinal and the cross-sectional version in various situations of lesion load progression. Finally, applied to clinical data, the proposed framework demonstrates an increased robustness compared to available cross-sectional methods and findings are aligned with previously reported clinical patterns.
authors.affiliation: Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK; Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK. Electronic address: carole.sudre.12@ucl.ac.uk.
authors.forename: Carole H
authors.initials: CH
authors.lastname: Sudre
authors.affiliation: Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK; Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
authors.forename: M Jorge
authors.initials: MJ
authors.lastname: Cardoso
authors.affiliation: Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK; Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Ourselin
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology*; D000465:Algorithms; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics; D015982:Bias; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D015203:Reproducibility of Results; D066127:White Matter / Q000000981:diagnostic imaging* / Q000473:pathology*
chemical_list: D001057:Apolipoproteins E
keywords: Longitudinal; Segmentation; White matter hyperintensities