title: Keratoacanthoma Centrifugum Marginatum: Response to Acitretin.
abstract: A previously healthy 70-year-old woman presented with a 5-month history of an asymptomatic keratotic, papulonodular plaque on her right forearm. The lesion started as a follicular papule followed by progressive peripheral proliferation. No record of trauma, contact with any chemicals, use of immunosuppressive drugs, or history of neoplasm was noted. Clinical examination showed an arciform plaque of 10×5 cm, with infiltrated raised borders and central atrophy (Figure 1). Drops of yellowish material exuded from the coalescent nodules constituting an elevated and indurate border. Results from physical and laboratory examinations revealed no internal organ malignancy. The remainder of the physical examination (x-ray of the forearm and serologies for HIV, hepatitis, and syphilis) was normal.
authors.affiliation: Department of Dermatology, La Rabta Hospital Tunis, Tunis, Tunisia.
authors.forename: Abdulmohti
authors.initials: A
authors.lastname: Hawilo
authors.affiliation: Department of Dermatology, La Rabta Hospital Tunis, Tunis, Tunisia; inesrania@myway.com.|Faculté de médicine de Tunis, Université El Manar, Tunis, Tunisia.
authors.forename: Ines
authors.initials: I
authors.lastname: Zaraa
authors.affiliation: Department of Dermatology, La Rabta Hospital Tunis, Tunis, Tunisia.
authors.forename: Dalenda
authors.initials: D
authors.lastname: El Euch
authors.affiliation: Department of Dermatology, La Rabta Hospital Tunis, Tunis, Tunisia.|Faculté de médicine de Tunis, Université El Manar, Tunis, Tunisia.
authors.forename: Mourad
authors.initials: M
authors.lastname: Mokni
authors.affiliation: Faculté de médicine de Tunis, Université El Manar, Tunis, Tunisia.|Department of Pathology, Pasteur Institute of Tunis, Tunis, Tunisia.
authors.forename: Samir
authors.initials: S
authors.lastname: Boubaker
authors.affiliation: Department of Dermatology, La Rabta Hospital Tunis, Tunis, Tunisia.|Faculté de médicine de Tunis, Université El Manar, Tunis, Tunisia.
authors.forename: Amel Ben
authors.initials: AB
authors.lastname: Osman
mesh_terms: D017255:Acitretin / Q000627:therapeutic use*; D000284:Administration, Oral; D000368:Aged; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005542:Forearm; D006801:Humans; D007636:Keratoacanthoma / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D007641:Keratolytic Agents / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D007641:Keratolytic Agents; D017255:Acitretin