title: The Maize MID-COMPLEMENTING ACTIVITY Homolog CELL NUMBER REGULATOR13/NARROW ODD DWARF Coordinates Organ Growth and Tissue Patterning.
abstract: Organogenesis occurs through cell division, expansion, and differentiation. How these cellular processes are coordinated remains elusive. The maize (Zea mays) leaf provides a robust system to study cellular differentiation due to its distinct tissues and cell types. Thenarrow odd dwarf(nod) mutant displays defects at both the cellular and tissue level that increase in severity throughout growth.nodmutant leaves have reduced size due to fewer and smaller cells compared with the wild type. The juvenile-to-adult transition is delayed, and proximal distal-patterning is abnormal in this mutant. Differentiation of specialized cells such as those forming stomata and trichomes is incomplete. Analysis ofnod-1sectors suggests that NOD plays a cell-autonomous function in the leaf. We clonednodpositionally and found that it encodes CELL NUMBER REGULATOR13 (CNR13), the maize MID-COMPLEMENTING ACTIVITY homolog. CNR13/NOD is localized to the membrane and is enriched in dividing tissues. Transcriptome analysis ofnodmutants revealed overrepresentation of cell wall, hormone metabolism, and defense gene categories. We propose that NOD coordinates cell activity in response to intrinsic and extrinsic cues.
authors.affiliation: Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, California 94720.
authors.forename: Marisa
authors.identifier: http://orcid.org/0000-0003-2793-8560
authors.initials: M
authors.lastname: Rosa
authors.affiliation: Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, California 94720.
authors.forename: María Jazmín
authors.identifier: http://orcid.org/0000-0002-5468-8176
authors.initials: MJ
authors.lastname: Abraham-Juárez
authors.affiliation: Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, California 94720.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Lewis
authors.affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143.
authors.forename: João Pedro
authors.initials: JP
authors.lastname: Fonseca
authors.affiliation: Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, California 94720.
authors.forename: Wang
authors.initials: W
authors.lastname: Tian
authors.affiliation: Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, California 94720.
authors.forename: Vicente
authors.initials: V
authors.lastname: Ramirez
authors.affiliation: Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, California 94720.
authors.forename: Sheng
authors.initials: S
authors.lastname: Luan
authors.affiliation: Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, California 94720.
authors.forename: Markus
authors.initials: M
authors.lastname: Pauly
authors.affiliation: Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, California 94720 hake@berkeley.edu.|Plant Gene Expression Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, California 94710.
authors.forename: Sarah
authors.identifier: http://orcid.org/0000-0001-6953-1529
authors.initials: S
authors.lastname: Hake
mesh_terms: D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D002473:Cell Wall / Q000235:genetics / Q000378:metabolism; D010105:Oxygenases / Q000235:genetics / Q000378:metabolism; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D054046:Plant Stomata / Q000235:genetics / Q000378:metabolism; D059467:Transcriptome / Q000235:genetics; D003313:Zea mays / Q000235:genetics / Q000378:metabolism*
chemical_list: D010940:Plant Proteins; D010105:Oxygenases; C114415:nitric oxide dioxygenase