title: Prognostic impact of myocardial perfusion single photon emission computed tomography in patients with major extracardiac findings by computed tomography for attenuation correction.
abstract: Attenuation correction computed tomography (CT) contributes to an improvement in the diagnostic accuracy of myocardial perfusion imaging (MPI) by single photon emission tomography (SPECT). The aim of this study was to explore the prognosis of patients with major findings by CT according to the results of MPI.
  
  
  
  1506 patients who underwent MPI by SPECT were retrospectively included. Attenuation correction CT images were systematically analyzed for major and minor abnormalities. 830 (55.1%) and 212 (14.1%) patients had minor and major extracardiac findings, respectively. Among patients with major extracardiac findings, the abnormality was previously unknown in 113 (53.3%) patients. 90 (41.9%) had abnormal MPI, 73 (34.4%) had a myocardial infarction scar, 55 (25.9%) had myocardial ischemia, and 38 (17.7%) patients had both myocardial infarction scar and myocardial ischemia. Among the 201 patients available for survival analysis, there were 67 (31.2%) deaths over a follow-up period of 3.2±1.3 years. There was no significant impact on survival arising from MPI, whatever the result. The results were the same among the 103 patients with previously unknown major extracardiac findings.
  
  
  
  Extracardiac findings by CT during MPI are frequent. Patients with major extracardiac findings have a poor mid-term outcome, whatever the results of the myocardial perfusion imaging. Extracardiac findings should be systematically checked when attenuation correction CT is performed.
authors.affiliation: Department of Radiology, Toulouse University Hospital, Toulouse, France.|Cardiac Imaging Center, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.
authors.forename: Charline
authors.initials: C
authors.lastname: Zadro
authors.affiliation: Department of Radiology, Toulouse University Hospital, Toulouse, France.|Cardiac Imaging Center, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.
authors.forename: Noé
authors.initials: N
authors.lastname: Roussel
authors.affiliation: Cardiac Imaging Center, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.|Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.|Medical School of Rangueil, University Paul Sabatier, Toulouse, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Cassol
authors.affiliation: Cardiac Imaging Center, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.|Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Pascal
authors.affiliation: Department of Radiology, Toulouse University Hospital, Toulouse, France.|Cardiac Imaging Center, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Petermann
authors.affiliation: Department of Radiology, Toulouse University Hospital, Toulouse, France.|Cardiac Imaging Center, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Meyrignac
authors.affiliation: Department of Radiology, Toulouse University Hospital, Toulouse, France.|Cardiac Imaging Center, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Jaffro
authors.affiliation: Cardiac Imaging Center, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.|Department of Cardiology, University Hospital of Rangueil, Toulouse, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Fournier
authors.affiliation: Department of Cardiology, Gabriel Martin Hospital, Saint-Paul, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Cournot
authors.affiliation: Cardiac Imaging Center, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.|Medical School of Rangueil, University Paul Sabatier, Toulouse, France.|Department of Cardiology, University Hospital of Rangueil, Toulouse, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Galinier
authors.affiliation: Department of Cardiology, University Hospital of Rangueil, Toulouse, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Carrié
authors.affiliation: Department of Radiology, Toulouse University Hospital, Toulouse, France.|Cardiac Imaging Center, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.|Medical School of Rangueil, University Paul Sabatier, Toulouse, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Rousseau
authors.affiliation: Cardiac Imaging Center, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.|Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.|Medical School of Rangueil, University Paul Sabatier, Toulouse, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Berry
authors.affiliation: Cardiac Imaging Center, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France. Lairez@gmail.com.|Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France. Lairez@gmail.com.|Medical School of Rangueil, University Paul Sabatier, Toulouse, France. Lairez@gmail.com.|Department of Cardiology, University Hospital of Rangueil, Toulouse, France. Lairez@gmail.com.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lairez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000401:mortality; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000401:mortality; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Myocardial perfusion imaging; computed tomography; extracardiac findings; prognosis; single photon emission computed tomography