title: Signalling in the gut endocrine axis.
abstract: Enteroendocrine cells are sensory cells located in the intestinal epithelium that produce a variety of hormonal regulators of gastrointestinal physiology, metabolism and food intake. They detect the absorption of a wide range of ingested nutrients via pathways that include transporter-mediated uptake, G-protein coupled receptors and ion channels. This review will describe mechanisms by which the L-cells that produce Glucagon Like Peptide-1 (GLP-1) respond to different components of ingested food, and the importance of these pathways not only for understanding physiology, but also for developing new treatments for type 2 diabetes and obesity.
authors.affiliation: Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address: fmg23@cam.ac.uk.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Gribble
authors.affiliation: Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
authors.forename: Frank
authors.initials: F
authors.lastname: Reimann
mesh_terms: D000818:Animals; D019858:Enteroendocrine Cells / Q000378:metabolism*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D005768:Gastrointestinal Hormones