title: Safety of Daiobotampito in the Treatment of Acute Diverticulitis of the Colon: A Single-Center, Open-Label, Prospective Trial.
abstract: OBJECTIVE
  The purpose of this study was to investigate the safety of daiobotampito in the treatment of acute diverticulitis of the colon.
  
  
  METHODS
  We conducted a single-center, open-label, prospective study. Ten patients who suffered from diverticulitis of the colon were recruited. The patients were treated with fasting, antibacterial agents, and daiobotampito extract for 10 days in or out of hospital. The patients individually recorded their body temperature, grade of abdominal pain, number of times that analgesics were used, and number of stools daily. We checked whether the patients had adverse reactions such as abdominal pain or diarrhea.
  
  
  RESULTS
  No patients experienced serious adverse reactions. One patient had moderate abdominal pain and diarrhea soon after daiobotampito intake. This patient discontinued daiobotampito on day 4, and the pain and diarrhea quickly resolved. The abdominal pain of this patient was worse 6 days before treatment, and the pain was almost relieved with initial daiobotampito treatment.
  
  
  CONCLUSIONS
  Daiobotampito is a safe treatment option for early stage, acute diverticulitis.
authors.affiliation: 1 Center for Kampo Medicine, Keio University School of Medicine , Tokyo, Japan .|2 Department of General Internal Medicine, Tokyo Saiseikai Central Hospital , Tokyo, Japan .
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koike
authors.affiliation: 3 Department of Internal Medicine, Tokyo Saiseikai Central Hospital , Tokyo, Japan .
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakazawa
authors.affiliation: 1 Center for Kampo Medicine, Keio University School of Medicine , Tokyo, Japan .
authors.forename: Yuko
authors.initials: Y
authors.lastname: Horiba
authors.affiliation: 3 Department of Internal Medicine, Tokyo Saiseikai Central Hospital , Tokyo, Japan .
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tsukada
authors.affiliation: 1 Center for Kampo Medicine, Keio University School of Medicine , Tokyo, Japan .
authors.forename: Kenji
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D015746:Abdominal Pain; D000208:Acute Disease; D000328:Adult; D000368:Aged; D003967:Diarrhea; D004239:Diverticulitis, Colonic / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Kampo medicine; daiobotampito; phase II trial; safety