title: Pathological and Therapeutic Aspects of Long noncoding RNAs in osteosarcoma.
abstract: BACKGROUND
  Osteosarcoma (OS) is a common bone malignant tumor, which is the eighth leading form of pediatric cancer. Despite the modern chemotherapeutic development of OS, a number of patients with OS have a high risk of lung metastasis and local relapse after chemotherapy.
  
  
  OBJECTIVE
  This review study focused on the role of long non coding RNAs (lncRNAs) in OS progression, and presented update reports on OS treatment by targeting specific lncRNAs.
  
  
  METHODS
  We have acquired information on OS and lncRNAs from scientific databases like google scholar, pubmed and scopus, and reviewed for this study.
  
  
  RESULTS
  The lncRNAs regulate a number of biological processes, and abnormal expression of lncRNAs could play role in many cancers and other human diseases. Interestingly, some lncRNAs can act as oncogenes, while some act as tumor suppressor genes. A number of studies revealed that targeting the specific lncRNAs by RNA interferance technology may provide a novel therapeutic strategy in the treatment of OS.
  
  
  CONCLUSIONS
  LncRNAs could be a promising biomarker and might be a potential therapeutic target in OS patients.
authors.affiliation: Second People`s Hospital of Jingmen - Department of gynaecology Jingmen, China.
authors.forename: Kaixiu
authors.initials: K
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Chao
authors.initials: C
authors.lastname: Cheng
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Tu
keywords: Cancer therapeutics; diagnostic markers; long noncoding RNA; osteosarcoma