title: Polymorphisms in the IL-17 Gene (rs2275913 and rs763780) Are Associated with Hepatitis B Virus Infection in the Han Chinese Population.
abstract: OBJECTIVE
  Interleukin-17 (IL-17) can accelerate the release of many pro-inflammatory cytokines. The purpose of our study was to investigate the potential association between polymorphisms in the IL-17 gene and susceptibility to hepatitis B virus (HBV) infection in the Han Chinese population.
  
  
  METHODS
  We recruited 596 HBV-infected patients and 612 ethnically matched controls, who were then genotyped for the IL-17A and IL-17F polymorphisms, rs2275913 and rs763780, respectively, by using TaqMan probe-based real-time polymerase chain reaction. The frequencies of the alleles and genotypes in patients and controls were compared by the χ2test.
  
  
  RESULTS
  Statistically significant differences in genotypic and allelic frequencies were revealed at both polymorphic sites between HBV-positive patients and controls (rs2275913: genotype χ2= 37.74, p < 0.001 and allele χ2= 22.17, p < 0.001, odds ratio [OR] = 0.654, 95% confidence interval [CI] = 0.548-0.781. rs763780: genotype χ2= 19.80, p < 0.001 and allele χ2= 18.78, p < 0.001, OR = 0.507, 95% CI = 0.371-0.692).
  
  
  CONCLUSIONS
  These results indicate that the IL-17A rs2275913 and IL-17F rs763780 polymorphisms are associated with HBV infection in the Han Chinese population. We conclude that possession of the GG genotype and the G allele at rs2275913, and the TT genotype and the T allele at rs763780 might increase the risk of HBV infection. Larger-scale, multiracial studies are necessary to evaluate the role of IL-17 polymorphisms in relation to an enhanced risk of HBV infection.
authors.affiliation: 1 Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University , Qingdao, China .
authors.forename: Wei
authors.initials: W
authors.lastname: Ren
authors.affiliation: 2 Department of Hepatobiliary Surgery, The Affiliated Hospital of Qingdao University , Qingdao, China .
authors.forename: Zehua
authors.initials: Z
authors.lastname: Wu
authors.affiliation: 3 Department of Endocrinology, The Affiliated Hospital of Qingdao University , Qingdao, China .
authors.forename: Ruixin
authors.initials: R
authors.lastname: Ma
authors.affiliation: 1 Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University , Qingdao, China .
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: 4 Department of Dermatology, The Affiliated Hospital of Qingdao University , Qingdao, China .
authors.forename: Yingying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 2 Department of Hepatobiliary Surgery, The Affiliated Hospital of Qingdao University , Qingdao, China .
authors.forename: Liqun
authors.initials: L
authors.lastname: Wu
authors.affiliation: 5 Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University , Qingdao, China .
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.affiliation: 2 Department of Hepatobiliary Surgery, The Affiliated Hospital of Qingdao University , Qingdao, China .
authors.forename: Zusen
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006509:Hepatitis B / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17
keywords: gene polymorphism; hepatitis B; interleukin-17