title: Proposal for shorter antibiotic therapies.
abstract: OBJECTIVE
  Reducing antibiotic consumption has now become a major public health priority. Reducing treatment duration is one of the means to achieve this objective. Guidelines on the therapeutic management of the most frequent infections recommend ranges of treatment duration in the ratio of one to two. The Recommendation Group of the French Infectious Diseases Society (SPILF) was asked to collect literature data to then recommend the shortest treatment durations possible for various infections.
  
  
  METHODS
  Analysis of the literature focused on guidelines published in French and English, supported by a systematic search on PubMed. Articles dating from one year before the guidelines publication to August 31, 2015 were searched on the website.
  
  
  RESULTS
  The shortest treatment durations based on the relevant clinical data were suggested for upper and lower respiratory tract infections, central venous catheter-related and uncomplicated primary bacteremia, infective endocarditis, bacterial meningitis, intra-abdominal, urinary tract, upper reproductive tract, bone and joint, skin and soft tissue infections, and febrile neutropenia. Details of analyzed articles were shown in tables.
  
  
  CONCLUSIONS
  This work stresses the need for new well-conducted studies evaluating treatment durations for some common infections. Following the above-mentioned work focusing on existing literature data, the Recommendation Group of the SPILF suggests specific study proposals.
authors.affiliation: Département de médecine interne, CHU de Grenoble Alpes, 38043 Grenoble, France.
authors.forename: C
authors.initials: C
authors.lastname: Wintenberger
authors.affiliation: Service de maladies infectieuses, CHU vaudois et université de Lausanne, Lausanne, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Guery
authors.affiliation: Équipe mobile d'infectiologie, hôpital Joseph-Ducuing, 15, rue Varsovie, 31300 Toulouse, France.
authors.forename: E
authors.initials: E
authors.lastname: Bonnet
authors.affiliation: Unité fonctionnelle d'infectiologie régionale, hôpital Eugenie, boulevard Rossini, 20000 Ajaccio, France.
authors.forename: B
authors.initials: B
authors.lastname: Castan
authors.affiliation: IMRB-GRC GEMINI, unité Court Séjour, université Paris Est, Petits Nourrissons, centre hospitalier intercommunal de Créteil, ACTIV France, 40, avenue de Verdun, 94000 Créteil, France.
authors.forename: R
authors.initials: R
authors.lastname: Cohen
authors.affiliation: Service de maladies infectieuses et tropicales, centre hospitalier de Melun, 2, rue Fréteau-de-Peny, 77011 Melun cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Diamantis
authors.affiliation: Infectiologie transversale, hôpital Foch, 40, rue Worth, 92151 Suresnes, France.
authors.forename: P
authors.initials: P
authors.lastname: Lesprit
authors.affiliation: Centre hospitalier du Pays-d'Aix, avenue de Tamaris, 13616 Aix-en-Provence, France.
authors.forename: L
authors.initials: L
authors.lastname: Maulin
authors.affiliation: Observatoire national de l'épidémiologie de la résistance bactérienne aux antibiotiques (ONERBA), 10, rue de la Bonne-Aventure, 78000 Versailles, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Péan
authors.affiliation: Département d'infectiologie, CHU de Dijon, 14, rue Gaffarel, 21079 Dijon cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Peju
authors.affiliation: Département d'infectiologie, CHU de Dijon, 14, rue Gaffarel, 21079 Dijon cedex, France.
authors.forename: L
authors.initials: L
authors.lastname: Piroth
authors.affiliation: Infectiologie, université, CHU de Grenoble Alpes, 38043 Grenoble, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Stahl
authors.affiliation: Cabinet d'infectiologie, clinique Saint-André, groupe Courlancy, 5, boulevard de la Paix, 51100 Reims, France.
authors.forename: C
authors.initials: C
authors.lastname: Strady
authors.affiliation: Laboratoire de microbiologie, hôpital européen Georges-Pompidou, 75908 Paris cedex 15, France.
authors.forename: E
authors.initials: E
authors.lastname: Varon
authors.affiliation: Service de maladies infectieuses, CHU vaudois et université de Lausanne, Lausanne, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Vuotto
authors.affiliation: Réanimation et infectiologie transversale, hôpital Cochin, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. Electronic address: remy.gauzit@aphp.fr.
authors.forename: R
authors.initials: R
authors.lastname: Gauzit
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy*; D004363:Drug Utilization / Q000706:statistics & numerical data; D006801:Humans; D017410:Practice Guidelines as Topic; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiothérapie; Antibiotic consumption; Antibiotic stewardship; Antibiotic therapy; Bon usage; Consommation d’antibiotiques; Durée de traitement; Short treatment; Traitement court; Treatment duration