title: Trials Testing the Value of Imaging Use in Valve Disease and in Transcatheter Valvular Interventions.
abstract: The role of imaging in the diagnosis of valvular heart disease is well established through years of investigation and validation. However, the role of imaging in guiding the treatment decision-making for valvular heart disease is less well established, and there is a striking paucity of randomized trial data to help inform these decisions. Given this relative absence of randomized trial data, the present article highlights some of the most important knowledge gaps and defines meaningful opportunities for the field to help advance the care of patients with valvular heart disease in a cost-effective fashion. (The PARTNER 3-Trial: The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis [P3]; NCT02675114; Medtronic Transcatheter Aortic Valve Replacement in Low Risk Patients; NCT02701283).
authors.affiliation: Department of Radiology and Cardiology, Centre for Heart Valve Innovation, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: jleipsic@providencehealth.bc.ca.
authors.forename: Jonathon
authors.initials: J
authors.lastname: Leipsic
authors.affiliation: Leiden University Medical Center, Leiden, the Netherlands.
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bax
authors.affiliation: Department of Radiology and Cardiology, Centre for Heart Valve Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: John G
authors.initials: JG
authors.lastname: Webb
authors.affiliation: Piedmont Medical Center, Atlanta, Georgia.
authors.forename: Randolph
authors.initials: R
authors.lastname: Martin
authors.affiliation: Department of Radiology and Cardiology, Centre for Heart Valve Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Philipp
authors.initials: P
authors.lastname: Blanke
mesh_terms: D001021:Aortic Valve / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery*; D057791:Cardiac Imaging Techniques; D000066491:Clinical Decision-Making; D002986:Clinical Trials as Topic / Q000379:methods*; D003661:Decision Support Techniques; D006801:Humans; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012107:Research Design; D065467:Transcatheter Aortic Valve Replacement / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome
keywords: TAVR; aortic stenosis; transcatheter mitral valve replacement; valvular heart disease