title: Flexible magnetic polyurethane/Fe2O3nanoparticles as organic-inorganic nanocomposites for biomedical applications: Properties and cell behavior.
abstract: Nowadays, the discovery of cell behaviors and their responses in communication with the stem cell niches and/or microenvironments are one of the major topics in tissue engineering and regenerative medicine. In this study, incorporated organic-inorganic polyurethane (PU) nanocomposites were prepared for better understanding of cell signaling and the effect of magnetite nanoparticles on cell proliferation and cell responses. The properties of PU-IONs were evaluated by fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic-force microscopy (AFM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and electrochemical impedance spectroscopy (EIS). The presence of the iron oxide nanoparticles (IONs) affects on the properties of polyurethane nanocomposites such as bulk morphology, mechanical, electrochemical, and biological properties. The electrical conductivity and hydrophilicity of PU-IONs were improved by increasing the magnetite nanoparticles; therefore water absorption, biodegradation and cell viability were changed. The biocompatibility of PU-IONs was investigated by MTT assay, cell attachment and cell staining. According to the results, the magnetite polyurethane nanocomposites could be a potential choice for cell therapy and tissue engineering, especially nerve repair.
authors.affiliation: Department of Polymer Engineering & Color Technology, Amirkabir University of Technology, P.O. Box 15875/4413, Tehran, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Shahrousvand
authors.affiliation: Department of Medical Nanotechnology, Faculty of Advanced Sciences and Technology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran.
authors.forename: Monireh Sadat
authors.initials: MS
authors.lastname: Hoseinian
authors.affiliation: Department of Cell & Molecular Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Ghollasi
authors.affiliation: Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Karbalaeimahdi
authors.affiliation: Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: salimiali@bmsu.ac.ir.
authors.forename: Ali
authors.initials: A
authors.lastname: Salimi
authors.affiliation: Department of Polymer Engineering & Color Technology, Amirkabir University of Technology, P.O. Box 15875/4413, Tehran, Iran.
authors.forename: Fatemeh Ahmadi
authors.initials: FA
authors.lastname: Tabar
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D058266:Dielectric Spectroscopy; D005290:Ferric Compounds / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D017155:Wettability; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D011140:Polyurethanes; C000499:ferric oxide
keywords: Cell proliferation; Cell viability; Magnetic nanoparticle; Nanocomposite; Polyurethane