title: Age-Specific IVF Outcomes in Infertile Women With Baseline FSH Levels ≥20 mIU/mL.
abstract: Infertile women with severely diminished ovarian reserve who have low birth chances with in vitro fertilization (IVF) are often denied treatment with autologous oocytes. This study was designed to determine age-specific treatment efficacy and clinical characteristics of infertile women with severely diminished ovarian reserve who had live birth following IVF with autologous oocytes.
  
  
  
  This retrospective cohort study investigated 291 infertile women who underwent 482 IVF cycles with autologous oocytes during 2004 to 2016 at our academically affiliated private fertility center. All women were aged <45 years and had maximum baseline follicle-stimulating hormone (FSH) levels ≥20 mIU/mL. Main outcome measures included pregnancy, spontaneous abortion, and live birth rates. Patient and treatment characteristics were compared for women who achieved a live birth to those who did not.
  
  
  
  Live birth rates were 8.6% per treated woman and 6% per started IVF cycle. The spontaneous abortion risk was 27% per clinical pregnancy. Age-specific live birth rates were highest at 17.2% for women <35 years and lowest at 1.9% for women >42 years. Women who achieved live birth were younger than those who did not (38.0 ± 8.0 vs 40.0 ± 6.0; P = .008), had lower FSH levels (25.0 ± 20.0 vs 32.5 ± 31.0; P = .006), and produced more oocytes (3.0 ± 5.0 vs 1.0 ± 2.0; P < .001), as well as transferrable embryos (2.0 ± 2.0 vs 0.0 ± 1.0; P < .001).
  
  
  
  Infertile women up to 45 years with severely diminished ovarian reserve achieve better live birth rates than previously reported and should not be denied access to IVF based on elevated FSH levels alone.
authors.affiliation: 1 Center for Human Reproduction, New York, NY, USA.|2 Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
authors.forename: Vitaly A
authors.initials: VA
authors.lastname: Kushnir
authors.affiliation: 1 Center for Human Reproduction, New York, NY, USA.
authors.forename: Maxie
authors.initials: M
authors.lastname: Safdie
authors.affiliation: 1 Center for Human Reproduction, New York, NY, USA.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Darmon
authors.affiliation: 1 Center for Human Reproduction, New York, NY, USA.|3 Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA.|4 Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY, USA.
authors.forename: David F
authors.initials: DF
authors.lastname: Albertini
authors.affiliation: 1 Center for Human Reproduction, New York, NY, USA.|5 Foundation for Reproductive Medicine, New York, NY, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Barad
authors.affiliation: 1 Center for Human Reproduction, New York, NY, USA.|4 Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY, USA.|5 Foundation for Reproductive Medicine, New York, NY, USA.|6 Department of Obstetrics and Gynecology, University of Vienna School of Medicine, Vienna, Austria.
authors.forename: Norbert
authors.initials: N
authors.lastname: Gleicher
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D000367:Age Factors; D004624:Embryo Transfer / Q000706:statistics & numerical data; D005260:Female; D005307:Fertilization in Vitro; D043373:Follicle Stimulating Hormone, Human / Q000097:blood*; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000628:therapy*; D065851:Ovarian Reserve; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D043373:Follicle Stimulating Hormone, Human
keywords: IVF; diminished ovarian reserve; infertility; live birth rates