title: Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?
abstract: Carbonic anhydrases have started to emerge as new potential antibacterial targets for several pathogens. Two β-carbonic anhydrases, denominated bsCA I and bsCA II, have been isolated and characterized from the bacterial pathogen Brucella suis, the causative agent of brucellosis or Malta fever. These enzymes have been investigated in detail and a wide range of classical aromatic and heteroaromatic sulfonamides as well as carbohydrate-based compounds have been found to inhibit selectively and efficiently Brucella suis carbonic anhydrases. Inhibition of these metalloenzymes constitutes a novel approach for the potential development of new anti-Brucella agents. This review aims at discussing the recent literature on this topic.
authors.affiliation: a Institut de Recherche en Infectiologie de Montpellier (IRIM) UMR 9004, Université de Montpellier, CNRS , Montpellier , France.
authors.forename: Stephan
authors.initials: S
authors.lastname: Köhler
authors.affiliation: a Institut de Recherche en Infectiologie de Montpellier (IRIM) UMR 9004, Université de Montpellier, CNRS , Montpellier , France.
authors.forename: Safia
authors.initials: S
authors.lastname: Ouahrani-Bettache
authors.affiliation: b Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS, ENSCM, Université de Montpellier, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier , Montpellier , France.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Winum
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D041021:Brucella suis / Q000187:drug effects* / Q000201:enzymology*; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D002256:Carbonic Anhydrases
keywords: Brucella; Metalloenzyme; anti-infective agents; carbonic anhydrase; inhibitors