title: Antibody Mimetics, Peptides, and Peptidomimetics.
abstract: In spite of their widespread applications as therapeutic, diagnostic, and detection agents, the limitations of polyclonal and monoclonal antibodies have enthused scientists to plan for next-generation biomedical agents, the so-called antibody mimetics, which offer many advantages compared to traditional antibodies. Antibody mimetics could be designed through protein-directed evolution or fusion of complementarity-determining regions with intervening framework regions. In the recent decade, extensive progress has been made in exploiting human, butterfly (Pieris brassicae), and bacterial systems to design and select mimetics using display technologies. Notably, some of the mimetics have made their way to market. Numerous limitations lie ahead in developing mimetics for different biomedical usage, particularly for which conventional antibodies are ineffective. This chapter presents a brief overview of the current characteristics, construction, and applications of antibody mimetics.
authors.affiliation: College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling, 712100, Shaanxi, China. zhang.xy@nwsuaf.edu.cn.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling, 712100, Shaanxi, China.|Department of Microbiology, Karpagam University, Coimbatore, Tamil Nadu, India.
authors.forename: Thirumalai
authors.initials: T
authors.lastname: Diraviyam
mesh_terms: D000818:Animals; D000906:Antibodies / Q000235:genetics / Q000378:metabolism*; D022801:Complementarity Determining Regions / Q000235:genetics / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D010446:Peptide Fragments / Q000235:genetics / Q000378:metabolism; D057786:Peptidomimetics / Q000378:metabolism*; D015202:Protein Engineering
chemical_list: D000906:Antibodies; D022801:Complementarity Determining Regions; D010446:Peptide Fragments; D057786:Peptidomimetics
keywords: Antibody mimetics; Diagnostics; Monoclonal antibodies (mAbs); Protein engineering; Therapeutics