title: Resting-State Networks as Simultaneously Measured with Functional MRI and PET.
abstract: Functional MRI (fMRI) studies reported disruption of resting-state networks (RSNs) in several neuropsychiatric disorders. PET with18F-FDG captures neuronal activity that is in steady state at a longer time span and is less dependent on neurovascular coupling.Methods:In the present study, we aimed to identify RSNs in18F-FDG PET data and compare their spatial pattern with those obtained from simultaneously acquired resting-state fMRI data in 22 middle-aged healthy subjects.Results:Thirteen and 17 meaningful RSNs could be identified in PET and fMRI data, respectively. Spatial overlap was fair to moderate for the default mode, left central executive, primary and secondary visual, sensorimotor, cerebellar, and auditory networks. Despite recording different aspects of neural activity, similar RSNs were detected by both imaging modalities.Conclusion:The results argue for the common neural substrate of RSNs and encourage testing of the clinical utility of resting-state connectivity in PET data.
authors.affiliation: Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Savio
authors.affiliation: Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Fünger
authors.affiliation: Department of Neuroradiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.|Department of Nuclear Medicine, Universität zu Köln, Cologne, Germany.|Institute of Medical Science and Technology at Shahid Beheshti University and School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Tahmasian
authors.affiliation: The Mind Research Network and LBERI, Albuquerque, New Mexico.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Rachakonda
authors.affiliation: Department of Neuroradiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.|Department of Psychiatry, University of Zürich, Zurich, Switzerland.
authors.forename: Andrei
authors.initials: A
authors.lastname: Manoliu
authors.affiliation: Department of Neuroradiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.|Neuroimaging Center (TUM-NIC), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.|Department of Psychiatry and Psychotherapy, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; and.
authors.forename: Christian
authors.initials: C
authors.lastname: Sorg
authors.affiliation: Department of Psychiatry and Psychotherapy, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; and.
authors.forename: Timo
authors.initials: T
authors.lastname: Grimmer
authors.affiliation: The Mind Research Network and LBERI, Albuquerque, New Mexico.|Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, New Mexico.
authors.forename: Vince
authors.initials: V
authors.lastname: Calhoun
authors.affiliation: Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.|Department of Nuclear Medicine, Universität zu Köln, Cologne, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Drzezga
authors.affiliation: Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.|Department of Neuroradiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.|Neuroimaging Center (TUM-NIC), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Valentin
authors.initials: V
authors.lastname: Riedl
authors.affiliation: Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany igor.yakushev@tum.de.|Neuroimaging Center (TUM-NIC), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Igor
authors.initials: I
authors.lastname: Yakushev
mesh_terms: D001931:Brain Mapping; D005260:Female; D019788:Fluorodeoxyglucose F18; D064368:Healthy Volunteers; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009415:Nerve Net / Q000000981:diagnostic imaging* / Q000502:physiology; D049268:Positron-Emission Tomography; D012146:Rest / Q000502:physiology*
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: brain connectivity; glucose metabolism; independent component analysis; multimodal imaging; positron emission tomography