title: Two new lignans from Saururus chinensis.
abstract: Two new lignans, (Z)-14-bis(3',4'-dimethoxyphenyl)-2,3-dimethylbut-2-ene-1,4-dione (1), threo-2-methyl-3-oxo-1-(3',4',5'-trimethoxyphenyl)butyl-3″,4″-dimethoxybenzoate (2), together with 15 known derivatives (3-17) were isolated from Saururus chinensis. Their structures were determined on the basis of spectral data, including 1D and 2D NMR experiments and HREIMS spectra. The antitumour activity was screened by MTT assay, compounds 1, 2, 3, 5, 9-11 and 13-15 showed no cytotoxic activity against HL-60, SMMC-7721, A549, MCF-7 and SW480 cell lines.
authors.affiliation: a Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden , Chinese Academy of Sciences , Kunming , P.R. China.|b Department of medical , Dehong Vocational College , Dehong , P.R. China.
authors.forename: Cuibai
authors.initials: C
authors.lastname: Li
authors.affiliation: a Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden , Chinese Academy of Sciences , Kunming , P.R. China.|c College of life sciences , University of Chinese Academy of Sciences , Beijing , P.R. China.
authors.forename: Ningxin
authors.initials: N
authors.lastname: Li
authors.affiliation: b Department of medical , Dehong Vocational College , Dehong , P.R. China.
authors.forename: Jiarui
authors.initials: J
authors.lastname: Yue
authors.affiliation: a Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden , Chinese Academy of Sciences , Kunming , P.R. China.
authors.forename: Qishi
authors.initials: Q
authors.lastname: Song
authors.affiliation: a Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden , Chinese Academy of Sciences , Kunming , P.R. China.
authors.forename: Qingfei
authors.initials: Q
authors.lastname: Fan
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D032134:Saururaceae / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D017705:Lignans; D010936:Plant Extracts
keywords: Saururaceae; Saururus chinensis; antitumour activity; lignans