title: Platelet Count to Spleen Diameter Ratio for the Diagnosis of Gastroesophageal Varices in Liver Cirrhosis: A Systematic Review and Meta-Analysis.
abstract: Platelet count to spleen diameter ratio (PSR) was studied extensively as a noninvasive method of diagnosis for varices. The present study aimed to systematically assess the performance of PSR in the diagnosis of varices. PubMed, EMBASE, and article references were searched. The summary receiver operating characteristic curves (AUSROCs), sensitivities, specificities, positive and negative likelihood ratio, and diagnostic odds ratio were calculated. The heterogeneity, quality, and publication bias of studies were evaluated. Subgroup and sensitivity analyses were performed. A total of 49 papers were included. The AUSROCs of PSR for any varices and high-risk varices were 0.8719 and 0.8132, respectively. The summary sensitivities of PSR for any varices and high-risk varices were 0.84 and 0.78, respectively. The summary specificities of PSR for any varices and high-risk varices were 0.78 and 0.67, respectively. The AUSROC of PSR for any varices at the threshold of 909 was 0.8867. The AUSROC of PSR for any varices in viral liver cirrhosis was 0.8675. The overall quality of studies was moderate. Significant heterogeneity and publication bias existed in the study. In conclusion, PSR can be used to identify varices in liver cirrhosis. PSR had a high sensitivity in viral liver cirrhosis.
authors.affiliation: Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Runhua
authors.initials: R
authors.lastname: Chen
authors.affiliation: Postgraduate College, Dalian Medical University, Dalian, China.
authors.forename: Han
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Hospital Administration, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Xia
authors.identifier: 0000-0002-7346-942X
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Personnel, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Chune
authors.initials: C
authors.lastname: Xie
authors.affiliation: Department of Cardiology, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Massage and Physiotherapy, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Qian
authors.identifier: 0000-0002-0410-9797
authors.initials: Q
authors.lastname: Shen