title: [Meta-analysis for the relationship between lipoprotein-associated phospholipase A2 and ischemic stroke].
abstract: To analyze the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) and ischemic stroke.  Methods: Corresponding data, with case-control studies or cohorts regarding Lp-PLA2 and ischemic stroke, were retrieved from PubMed, Web of Science, Embase, the Cochrane Library, Chinese Biomedical Literature (CMB), VIP, China National Knowledge Infrastructure (CNKI), and Wanfang Database. Meta-analysis was performed by using Stata12.0.  Results: Eight studies including 46 034 participants met the inclusion criteria. Meta-analysis showed that the combined effect of relative risk (RR) between Lp-PLA2 mass and ischemic stroke was [1.04 (0.98 to 1.11)] and that the combined effect of RR between Lp-PLA2 activity and ischemic stroke was [1.03 (0.96 to 1.10)], suggesting that Lp-PLA2 mass and activity were not associated with ischemic stroke.  Conclusion: It cannot be considered that Lp-PLA2 mass and Lp-PLA2 activity was the risk factor for ischemic stroke.
authors.affiliation: Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013; Department of Neurology, Ningxiang General Hospital, Ningxiang Hunan 410600, China.
authors.forename: Wencui
authors.initials: W
authors.lastname: Xia
authors.affiliation: Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Zhongyang
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Song
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000502:physiology*; D002545:Brain Ischemia / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D020521:Stroke / Q000503:physiopathology*
chemical_list: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase