title: T-ALL and thymocytes: a message of noncoding RNAs.
abstract: In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs. This was also the case for T cell acute lymphoblastic leukemia, which is a malignant blood disorder arising from oncogenic events during normal T cell development in the thymus. By studying the transcriptomic profile of protein-coding genes, several oncogenic events leading to T cell acute lymphoblastic leukemia (T-ALL) could be identified. In recent years, it became apparent that several of these oncogenes function via microRNAs and long noncoding RNAs. In this review, we give a detailed overview of the studies that describe the noncoding RNAome in T-ALL oncogenesis and normal T cell development.
authors.affiliation: Center for Medical Genetics, Ghent University, Ghent, Belgium. annelynn.wallaert@ugent.be.|Cancer Research Institute Ghent, Ghent, Belgium. annelynn.wallaert@ugent.be.
authors.forename: Annelynn
authors.identifier: 0000-0002-5275-9591
authors.initials: A
authors.lastname: Wallaert
authors.affiliation: Center for Medical Genetics, Ghent University, Ghent, Belgium.|Cancer Research Institute Ghent, Ghent, Belgium.
authors.forename: Kaat
authors.initials: K
authors.lastname: Durinck
authors.affiliation: Cancer Research Institute Ghent, Ghent, Belgium.|Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium.
authors.forename: Tom
authors.initials: T
authors.lastname: Taghon
authors.affiliation: Center for Medical Genetics, Ghent University, Ghent, Belgium.|Cancer Research Institute Ghent, Ghent, Belgium.
authors.forename: Pieter
authors.initials: P
authors.lastname: Van Vlierberghe
authors.affiliation: Center for Medical Genetics, Ghent University, Ghent, Belgium.|Cancer Research Institute Ghent, Ghent, Belgium.
authors.forename: Frank
authors.initials: F
authors.lastname: Speleman
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics; D006801:Humans; D038041:Lymphopoiesis / Q000235:genetics; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D022661:RNA, Untranslated / Q000032:analysis / Q000502:physiology*; D060168:Thymocytes
chemical_list: D022661:RNA, Untranslated
keywords: LncRNA; MicroRNA; T-ALL; Thymocytes