title: Regenerated cellulose micro-nano fiber matrices for transdermal drug release.
abstract: In this work, biobased fibrous membranes with micro- and nano-fibers are fabricated for use as drug delivery carries because of their biocompatibility, eco-friendly approach, and potential for scale-up. The cellulose micro-/nano-fiber (CMF) matrices were prepared by electrospinning of pulp in an ionic liquid, 1-butyl-3-methylimidazolium chloride. A model drug, ibuprofen (IBU), was loaded on the CMF matrices by a simple immersing method. The amount of IBU loading was about 6% based on the weight of cellulose membrane. The IBU-loaded CMF matrices were characterized by Fourier-transform infrared spectroscopy, thermal gravimetric analysis, and scanning electron microscopy. The test of ibuprofen release was carried out in an acetate buffer solution of pH5.5 and examined by UV-Vis spectroscopy. Release profiles from the CMF matrices indicated that the drug release rate could be determined by a Fickian diffusion mechanism.
authors.affiliation: School of Human Ecology, The University of Texas at Austin, Austin, TX, USA; Department of Chemistry, School of Science, Tianjin University, Tianjin, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Nguyen
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
authors.forename: Alicia
authors.initials: A
authors.lastname: Allen
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
authors.forename: Janet
authors.initials: J
authors.lastname: Zoldan
authors.affiliation: School of Human Ecology, The University of Texas at Austin, Austin, TX, USA.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Huang
authors.affiliation: School of Human Ecology, The University of Texas at Austin, Austin, TX, USA. Electronic address: jychen2@austin.utexas.edu.
authors.forename: Jonathan Y
authors.initials: JY
authors.lastname: Chen
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002482:Cellulose / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D007052:Ibuprofen / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D052578:Ionic Liquids / Q000737:chemistry; D051379:Mice; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D017155:Wettability; D014961:X-Ray Diffraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D052578:Ionic Liquids; D002482:Cellulose; D007052:Ibuprofen
keywords: Cellulose; Drug delivery; Electrospinning; Ionic liquid; Microfiber; Nanofiber