title: A Voltage-Responsive Free-Blockage Controlled-Release System Based on Hydrophobicity Switching.
abstract: Controlled-release systems based on mesoporous silica nanomaterials (MSNs) have drawn great attention owing to their potential biomedical applications. Various switches have been designed to control the release of cargoes through the construction of physical blocking units on the surface of MSNs. However, such physical blockages are limited by poor sealing ability and low biocompatibility, and most of them lack closure ability. Herein, a voltage-responsive controlled-release system was constructed by functionalizing the nanopore of MSNs with ferrocene. The system realized free-blockage controlled release and achieved pulsatile release. The nanopores of the ferrocene-functionalized MSNs were hydrophobic enough to prevent invasion of the solution. Once a suitable voltage was applied, the nanopores became hydrophilic, which was followed by invasion of the solution and the release of the cargos. Moreover, pulsatile release was realized, which avoided unexpected release after the stimulus disappeared. Thus, we believe that our studies provide new insight into highly effective blockage for MSNs. Furthermore, the voltage-responsive release system is expected to find use in electrical stimulation combination therapy and bioelectricity-responsive release.
authors.affiliation: Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P.R. China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Jiao
authors.affiliation: Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P.R. China.
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Sun
authors.affiliation: Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P.R. China.
authors.forename: Yaya
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Key Laboratory of Green Printing, Key Lab of Organic Solids, Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Li
authors.affiliation: Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Du
authors.affiliation: Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P.R. China.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Key Laboratory of Green Printing, Key Lab of Organic Solids, Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Song
authors.affiliation: Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P.R. China.
authors.forename: Xueji
authors.initials: X
authors.lastname: Zhang
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry*; D004560:Electricity; D005296:Ferrous Compounds / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D000075163:Metallocenes / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D005296:Ferrous Compounds; D000075163:Metallocenes; D012822:Silicon Dioxide; C004998:ferrocene
keywords: controlled release; hydrophilic effect; hydrophobic effect; mesoporous materials; nanotechnology