title: Stroke in right dorsal anterior insular cortex Is related to myocardial injury.
abstract: OBJECTIVE
  Elevated levels of cardiac troponin, and especially their relative changes over time, indicate acute myocardial injury. They are also frequently observed after acute ischemic stroke (AIS), indicating poor functional outcome and increased mortality. However, recent evidence showed that, in most AIS patients, myocardial injury is not caused by coronary ischemia. Instead, stroke lesion location has been suggested to precipitate myocardial injury.
  
  
  METHODS
  Voxel-based lesion-symptom mapping (VLSM) was used in 299 patients who had a magnetic resonance imaging-confirmed acute ischemic stroke within the anterior circulation and a high-sensitivity cardiac troponin T (hs-cTnT) acquired on the day of admission. Of these, 228 had a second troponin measurement during the acute phase. The absolute hs-cTnT levels above the 99th percentile of a healthy reference population (≥14ng/l) as well as their relative temporal changes were used as continuous variables of interest in the VLSM model, including a multiple regression analysis adjusted for confounding variables.
  
  
  RESULTS
  The anterior insular cortex of the right hemisphere, in particular its dorsal subregion, was significantly associated with the relative temporal changes of hs-cTnT (p < 0.01, corrected for multiple comparisons). In contrast, the baseline hs-cTnT levels on admission were not related to lesion location anywhere within the anterior circulation.
  
  
  CONCLUSIONS
  Our results amplify recent evidence from functional neuroimaging, which suggests a prominent role of dorsal anterior insular cortex in the parasympathetic control of cardiac and autonomic function. Acute vascular damage of this insular subregion might lead to autonomic dysbalance and an upregulation of sympathetic function, thereby resulting in myocardial injury. Ann Neurol 2017;81:502-511.
authors.affiliation: Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany.|Charité-Universitätsmedizin Berlin, Department of Neurology, Berlin, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Krause
authors.affiliation: Charité-Universitätsmedizin Berlin, Department of Neurology, Berlin, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Werner
authors.affiliation: Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany.
authors.forename: Jochen B
authors.initials: JB
authors.lastname: Fiebach
authors.affiliation: Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany.
authors.forename: Kersten
authors.initials: K
authors.lastname: Villringer
authors.affiliation: Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany.
authors.forename: Sophie K
authors.initials: SK
authors.lastname: Piper
authors.affiliation: Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany.|Charité-Universitätsmedizin Berlin, Department of Neurology, Berlin, Germany.
authors.forename: Karl Georg
authors.initials: KG
authors.lastname: Haeusler
authors.affiliation: Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany.|Charité-Universitätsmedizin Berlin, Department of Neurology, Berlin, Germany.|German Center for Cardiovascular Research (DZHK), Berlin, Germany.|German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.|Berlin Institute of Health (BIH), Berlin, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Endres
authors.affiliation: Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany.|Charité-Universitätsmedizin Berlin, Department of Neurology, Berlin, Germany.
authors.forename: Jan F
authors.initials: JF
authors.lastname: Scheitz
authors.affiliation: Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany.|Charité-Universitätsmedizin Berlin, Department of Neurology, Berlin, Germany.
authors.forename: Christian H
authors.initials: CH
authors.lastname: Nolte
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D009202:Cardiomyopathies / Q000097:blood / Q000209:etiology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D020521:Stroke / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D020107:Troponin T / Q000097:blood*
chemical_list: D020107:Troponin T