title: A reduced lymphocyte ratio as an early marker for predicting acute pancreatitis.
abstract: The early diagnosis and severity grading for acute pancreatitis (AP) are difficult to determine because of the complexity and differences in disease process. To date, few studies have investigated the role of lymphocyte ratio (LR) in AP. Therefore, the objective of the present study was to investigate the prognostic value of LR as an indicator in AP, as well as determine an optimal cut-off value for the severity prediction. There were two hundred four patients involved in this study, ninety-two of whom had severe acute pancreatitis (SAP). The LR was analyzed on admission and correlated with severity, which was determined using the Atlanta classification. The optimal cut-off value for LR was generated using receiving operator characteristic (ROC) curves. The results showed that the LR in the SAP group decreased significantly compared to the mild acute pancreatitis (MAP) group (8.82 vs. 13.43). The optimal cut-off value obtained from ROC curves was 0.081, with a sensitivity of 80.4%, a specificity of 53.3%, a positive likelihood ratio of 1.722, and a negative likelihood ratio of 0.368. In conclusion, the LR is obviously related to the condition of AP patients and is valuable for the differential diagnosis of SAP in early stages of AP.
authors.affiliation: Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Shanghai 200433, China.|Department of Traditional Chinese Medicine, The Qingdao First Sanitarium of Navy, No. 27 Xianggang West Road, Qingdao 266071, China.
authors.forename: Xiuzhong
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Shanghai 200433, China.
authors.forename: Fangyong
authors.initials: F
authors.lastname: Yang
authors.affiliation: Laixi People’s Hospital, No. 69 Yantai Road, Laixi, 266600, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Gastroenterology, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Shanghai 200433, China.
authors.forename: Yiqi
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Gastroenterology, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Shanghai 200433, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of emergency, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Shanghai 200433, China.
authors.forename: Meitang
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Shanghai 200433, China.
authors.forename: Dezeng
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Department of Traditional Chinese Medicine, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai 200003, China.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Yue
authors.affiliation: Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Shanghai 200433, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Wang
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers