title: Microbe Hunting Hits Home.
abstract: Ten years ago, we discovered that microbiota composition controls intestinal T cell homeostasis and alters T cell responses of mice in different animal facilities. Here I discuss how these discoveries, reported in Cell Host & Microbe in 2008, came to be and contributed to our understanding of microbiota immune effects.
authors.affiliation: Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: ii2137@cumc.columbia.edu.
authors.forename: Ivaylo I
authors.initials: II
authors.lastname: Ivanov
mesh_terms: D000818:Animals; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology*; D006706:Homeostasis; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
keywords: Jackson; SFB; Taconic; Th17 cells; germ-free mice; gut; immunomodulatory bacteria; microbiota; segmented filamentous bacteria