title: Posterior tibial nerve stimulation using a wirelessly powered system in anesthetized cats.
abstract: Posterior Tibial Nerve Stimulation (PTNS) is an effective overactive bladder (OAB) therapy where electrical pulses are typically delivered once per week in a 12-week stimulation regime. While the mechanism of action remains unknown, effective long-term delivery of PTNS has recently become a subject of concern. To this end, a multi-contact electrode was surgically placed in the hind limb region of anesthetized cats to (1) investigate the feasibility of using a wirelessly powered system to stimulate PTN afferents and (2) characterize implant-driven effects of stimulation frequency on modulating bladder activity. Using an isovolumetric model, short-duration, supra-threshold stimulation trials were applied with frequencies ranging from 2-20 Hz. The results provide first pre-clinical evidence of frequency-dependent modulation of bladder function supporting the use of a novel therapeutic approach that can be clinically translated to potentially address multiple symptoms of lower urinary tract system.
authors.forename: Zainab
authors.initials: Z
authors.lastname: Moazzam
authors.forename: Austin R
authors.initials: AR
authors.lastname: Duke
authors.forename: Paul B
authors.initials: PB
authors.lastname: Yoo
mesh_terms: D000818:Animals; D002415:Cats; D004599:Electric Stimulation Therapy / Q000379:methods*; D004567:Electrodes, Implanted; D008297:Male; D013979:Tibial Nerve / Q000502:physiology*; D013997:Time Factors; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000628:therapy*; D059015:Wireless Technology