title: Older age at the completion of linear growth is associated with an increased risk of adult glioma.
abstract: OBJECTIVE
  To examine the association of age when adult height was attained with glioma risk.
  
  
  METHODS
  We analyzed data from a US-based case-control study of glioma risk factors. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) associated between age at attainment of adult height and glioma risk. Multivariate models were adjusted for age, race, sex, education, and state of residence. We examined associations overall, and according to glioma grade, sex, and final adult height.
  
  
  RESULTS
  The study set included n = 951 controls and n = 776 cases, with a median age of 56 (18-92); the majority was male (53.8%) and identified as Caucasian. Older age at height completion was associated with an increased risk of glioma. A significant positive trend was observed both for glioblastoma (OR 1.10; 95% CI 1.04-1.17 per 1-year increase in age) and lower grade non-glioblastoma subtypes combined (OR 1.18; 95% CI 1.10-1.28 per year increase in age). The association was observed in men and women, and in all categories of final adult height.
  
  
  CONCLUSIONS
  We observed for the first time a positive association between glioma risk and a prolonged adolescent growth phase. Our results suggest a role for factors governing the timing and intensity of growth in adolescence as risk-determining exposures in adult glioma.
authors.affiliation: Department of Nutrition Sciences, University of Alabama at Birmingham, Webb 449, 1675 University Blvd., Birmingham, AL, 35294, USA.
authors.forename: Rebecca B
authors.initials: RB
authors.lastname: Little
authors.affiliation: Neuro-oncology Program, University of Alabama at Birmingham, FOT 1020, 510 20th St. South, Birmingham, AL, 35294, USA.
authors.forename: L Burt
authors.initials: LB
authors.lastname: Nabors
authors.affiliation: Department of Neurosurgery, Emory University School of Medicine, 1365-B Clifton Rd., NE, Ste. 2200, Atlanta, GA, 30322, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Olson
authors.affiliation: Division of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
authors.forename: Zachary J
authors.initials: ZJ
authors.lastname: Thompson
authors.affiliation: Division of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
authors.forename: Carrie M
authors.initials: CM
authors.lastname: Rozmeski
authors.affiliation: Department of Hematology-Oncology, Norton Cancer Institute, 676 So Floyd St., Louisville, KY, 40202, USA.
authors.forename: Renato V
authors.initials: RV
authors.lastname: LaRocca
authors.affiliation: Department of Neuro-oncology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Forsyth
authors.affiliation: Department of Neurological Surgery, Vanderbilt University Medical Center, 691 Preston Building, Nashville, TN, 37232, USA.
authors.forename: Reid C
authors.initials: RC
authors.lastname: Thompson
authors.affiliation: Department of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, MT 642, 1717 11th Ave. South, Birmingham, AL, 35205, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Oster
authors.affiliation: Neuro-Oncology Program, Lynn Cancer Institute, 701 NW 13th Street, Boca Raton, FL, 33486, USA.
authors.forename: Sajeel A
authors.initials: SA
authors.lastname: Chowdhary
authors.affiliation: Division of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA. Kathleen.egan@moffitt.org.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Egan
mesh_terms: D000293:Adolescent; D041923:Adolescent Development; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001827:Body Height; D001932:Brain Neoplasms / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D005910:Glioma / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D055815:Young Adult
keywords: Adolescence; Case–control studies; Glioblastoma; Glioma; Height; Menarche