title: Aquaporins in Cardiovascular System.
abstract: Recent studies have shown that some aquaporins (AQPs ), including AQP1, AQP4, AQP7 and AQP9, are expressed in endothelial cells, vascular smooth muscle cells and heart of cardiovascular system. These AQPs are involved in the cardiovascular function and in pathological process of related diseases, such as cerebral ischemia , congestion heart failure , hypertension and angiogenesis. Therefore, it is important to understand the accurate association between AQPs and cardiovascular system, which may provide novel approaches to prevent and treat related diseases. Here we will discuss the expression and physiological function of AQPs in cardiovascular system and summarize recent researches on AQPs related cardiovascular diseases.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Tie
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
authors.forename: Yundi
authors.initials: Y
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, China. xjli@bjmu.edu.cn.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D051398:Aquaporin 1 / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D002545:Brain Ischemia / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002319:Cardiovascular System / Q000166:cytology / Q000378:metabolism*; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D005786:Gene Expression Regulation; D006333:Heart Failure / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D014867:Water / Q000378:metabolism
chemical_list: C496020:AQP1 protein, human; D020033:Protein Isoforms; D014867:Water; D051398:Aquaporin 1
keywords: Angiogenesis; Aquaporin; Cerebral ischemia; Congestion heart failure; Hypertension