title: Outcome of Kidney Transplant in Patients with Polycystic Kidney Disease: A Single-Center Study in Tunisia.
abstract: OBJECTIVE
  Autosomal dominant polycystic kidney disease is a common cause of end-stage renal disease and a common indication for renal transplant. This study was undertaken to evaluate the demographics, outcomes, and complications of renal transplant in patients with autosomal dominant polycystic kidney disease compared with other nephropathies.
  
  
  METHODS
  In a retrospective case-control design, we reviewed the records of 7 patients with autosomal dominant polycystic kidney disease from a total of 701 renal transplant patients over a 30-year period (1986-2016). For each patient, a matched control was selected based on sex, age, year of transplant, and type of kidney donor. We excluded patients who underwent kidney transplant abroad and those with a follow-up period of less than 2 years.
  
  
  RESULTS
  The number of patients with autosomal dominant polycystic kidney disease requiring transplant at our center was estimated at 0.23 per year, and the condition represented 1.57% of initial nephropathy causes. The mean patient age at transplant was 50.8 ± 8.05 years. There were 5 male and 2 female patients in the case group, with a male-to-female ratio of 2.5. The source of the graft was predominantly a living related donor (5/7). Four patients had extrarenal manifestations, the most common of which were liver cysts (3 patients). Rejection occurred in a single study patient (14.2%) and in 4 control patients (57.1%; P = .51). Two patients did not develop any complications. Complications noted after transplant included infection (3/7 cases vs 2/7 controls; P= .67) and cerebrovascular accidents (2/7 cases vs 0/7 controls).
  
  
  CONCLUSIONS
  Further studies with longer follow-up and greater numbers of patients are needed to compare more precisely the complications and results of transplant between patients with autosomal dominant polycystic kidney disease and other kidney transplant recipients.
authors.affiliation: Department of Nephrology, Charles Nicolle Hospital, Tunis, Tunisia.
authors.forename: Samia
authors.initials: S
authors.lastname: Barbouch
authors.forename: Meriam
authors.initials: M
authors.lastname: Hajji
authors.forename: Hafedh
authors.initials: H
authors.lastname: Hedri
authors.forename: Fethi
authors.initials: F
authors.lastname: El Younsi
authors.forename: Fathi
authors.initials: F
authors.lastname: Ben Hamida
authors.forename: Mohammed Mongi
authors.initials: MM
authors.lastname: Bacha
authors.forename: Mondher
authors.initials: M
authors.lastname: Ounissi
authors.forename: Ezzedine
authors.initials: E
authors.lastname: Abderrahim
authors.forename: Taieb
authors.initials: T
authors.lastname: Ben Abdallah
mesh_terms: D000328:Adult; D003141:Communicable Diseases / Q000209:etiology; D005260:Female; D006084:Graft Rejection / Q000209:etiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome; D014416:Tunisia