title: Inhibitors of Protein Tyrosine Phosphatase 1B from Marine Natural Products.
abstract: The ocean is a capacious area with the most abundant biological resources on the earth. The particularity of the marine ecological environment (high pressure, high salt, and hypoxia) makes the marine species survival competition fiercely, forcing many marine organisms in the process of life to produce a great deal of secondary metabolites with special structures and biological activities. In this article, 118 natural products which were isolated from four kinds of marine organisms, sponges, algae, soft corals and fungus, showing PTP1B inhibitory activity were summarized from 2010 to 2016, which may become the leading compounds towards treating Diabetes mellitus (DM). What's more, we briefly summarized the structure-activity relationship of PTP1B inhibitors.
authors.affiliation: Marine Biopharmaceutical Institute, Second Military Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.|Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai, 200433, P. R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Marine Biopharmaceutical Institute, Second Military Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.|Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai, 200433, P. R. China.
authors.forename: Weirui
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Marine Biopharmaceutical Institute, Second Military Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.|Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai, 200433, P. R. China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Liu
authors.affiliation: Marine Biopharmaceutical Institute, Second Military Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.|Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai, 200433, P. R. China.
authors.forename: Haobing
authors.initials: H
authors.lastname: Yu
authors.affiliation: Marine Biopharmaceutical Institute, Second Military Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.|Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai, 200433, P. R. China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Lu
authors.affiliation: Marine Biopharmaceutical Institute, Second Military Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.|Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai, 200433, P. R. China.
authors.forename: Binghua
authors.initials: B
authors.lastname: Jiao
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000188:drug therapy; D006801:Humans; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D001688:Biological Products; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
keywords: Inhibitory activity; Natural products; PTP1B; Secondary metabolites