title: Inflammatory bowel diseases activity in patients undergoing pelvic radiation therapy.
abstract: BACKGROUND
  Few studies with contradictory results have been published on the safety of pelvic radiation therapy (RT) in patients with inflammatory bowel disease (IBD).
  
  
  METHODS
  From 1989 to 2015, a single center retrospective analysis was performed including all IBD patients who received pelvic external beam radiation therapy (EBRT) or brachytherapy (BT) for a pelvic malignancy. Treatment characteristics, IBD activity and gastrointestinal (GI) toxicity were examined.
  
  
  RESULTS
  Overall, 28 patients with Crohn's disease (CD) (n=13) or ulcerative colitis (n=15) were included in the present study. Median follow-up time after irradiation was 5.9 years. Regarding IBD activity, only one and two patients experienced a severe episode within and after 6 months of follow-up, respectively. Grade 3/4 acute GI toxicity occurred in 3 (11%) patients, whereas one (3.6%) patient experienced late grade 3/4 GI toxicity. Only patients with rectal IBD location (P=0.016) or low body mass index (BMI) (P=0.012) experienced more severe IBD activity within or after 6 months following RT, respectively.
  
  
  CONCLUSIONS
  We report an acceptable tolerance of RT in IBD patients with pelvic malignancies. Specifically, a low risk of uncontrolled flare-up was observed.
authors.affiliation: Brachytherapy Unit, Gustave Roussy, Villejuif, France;; Department of Radiotherapy Department, Gustave Roussy, Villejuif, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Annede
authors.affiliation: Brachytherapy Unit, Gustave Roussy, Villejuif, France;; Department of Radiotherapy Department, Gustave Roussy, Villejuif, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Seisen
authors.affiliation: Department of Medical Oncology, Gustave Roussy, Villejuif, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Klotz
authors.affiliation: Brachytherapy Unit, Gustave Roussy, Villejuif, France;; Department of Radiotherapy Department, Gustave Roussy, Villejuif, France;; INSERM1030, Gustave Roussy Cancer Campus, Villejuif, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: Mazeron
authors.affiliation: Brachytherapy Unit, Gustave Roussy, Villejuif, France;; Department of Radiotherapy Department, Gustave Roussy, Villejuif, France;; INSERM1030, Gustave Roussy Cancer Campus, Villejuif, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Maroun
authors.affiliation: Brachytherapy Unit, Gustave Roussy, Villejuif, France;; Department of Radiotherapy Department, Gustave Roussy, Villejuif, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Petit
authors.affiliation: Department of Radiotherapy Department, Gustave Roussy, Villejuif, France;; INSERM1030, Gustave Roussy Cancer Campus, Villejuif, France;; Department of Molecular Radiotherapy, University Paris-Sud, SIRIC SOCRATES, Faculté de Médecine, Le Kremlin-Bicetre, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Deutsch
authors.affiliation: Brachytherapy Unit, Gustave Roussy, Villejuif, France;; Department of Radiotherapy Department, Gustave Roussy, Villejuif, France.
authors.forename: Alberto
authors.initials: A
authors.lastname: Bossi
authors.affiliation: Brachytherapy Unit, Gustave Roussy, Villejuif, France;; Department of Radiotherapy Department, Gustave Roussy, Villejuif, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Haie-Meder
authors.affiliation: Brachytherapy Unit, Gustave Roussy, Villejuif, France;; Department of Radiotherapy Department, Gustave Roussy, Villejuif, France;; INSERM1030, Gustave Roussy Cancer Campus, Villejuif, France;; NRBC Department, Institut de Recherche Biomédicale des Armées, Bretigny-sur-Orge, France.
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chargari
authors.affiliation: Brachytherapy Unit, Gustave Roussy, Villejuif, France;; Department of Radiotherapy Department, Gustave Roussy, Villejuif, France;; INSERM1030, Gustave Roussy Cancer Campus, Villejuif, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Blanchard
keywords: Inflammatory bowel disease (IBD); bowel toxicity; crohn disease; radiotherapy; ulcerative colitis