title: The Type I Interferon Response and Age-Dependent Susceptibility to Herpes Simplex Virus Infection.
abstract: Herpes simplex virus type 1 (HSV-1) is a highly prevalent human neurotropic pathogen. HSV-1 infection is associated with a variety of diseases ranging from benign orolabial lesions to more serious and even life-threatening conditions such as herpes simplex keratitis and herpes simplex encephalitis (HSE). HSE is a rare occurrence among healthy adult individuals, but newborns are a particularly susceptible population. Type I IFN signaling has been identified as a crucial component of the innate immune response to the control of HSV-1 infection. In this study, we review the contribution of the type I IFN response to controlling HSV-1 infection, and differences in the early host response between adults and newborns that may contribute to the increased susceptibility to infection and central nervous system disease in newborns.
authors.affiliation: Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine , Chicago, Illinois.
authors.forename: Daniel
authors.initials: D
authors.lastname: Giraldo
authors.affiliation: Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine , Chicago, Illinois.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Wilcox
authors.affiliation: Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine , Chicago, Illinois.
authors.forename: Richard
authors.initials: R
authors.lastname: Longnecker
mesh_terms: D000367:Age Factors; D004198:Disease Susceptibility; D006561:Herpes Simplex / Q000188:drug therapy* / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy / Q000453:epidemiology; D007370:Interferon Type I / Q000627:therapeutic use*; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D007370:Interferon Type I
keywords: HSV encephalitis; herpesvirus; interferon