title: High-fat diet effects on metabolic responses to chronic stress.
abstract: BACKGROUND
  High-fat diets and chronic stress are prevalent risk factors for various chronic diseases in modern societies.
  
  
  OBJECTIVE
  This study investigated the effect of high-fat diet on glucose-related metabolic responses to chronic foot-shock stress.
  
  
  METHODS
  Male rats were divided into high-fat diet (containing 54.21% saturated and 44.89% unsaturated fatty acids) and normal diet groups and then into stress and non-stress subgroups. The diets were applied for 5 weeks, and stress was induced during the last week of the diet course. Plasma levels of metabolic parameters, HOMA-IR index, intra-abdominal fat weight, and islets' insulin secretion were assessed.
  
  
  RESULTS
  High-fat diet increased abdominal fat weight and plasma leptin, and insulin levels in response to stress without affecting HOMA-IR index and islets' insulin secretion.
  
  
  CONCLUSIONS
  High proportion of unsaturated fat may not lead to deleterious metabolic responses; however combined with chronic stress has a synergistic and adverse effect on visceral adiposity and results in elevated plasma leptin.
authors.affiliation: a Neurophysiology Research Center and Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Nemati
authors.affiliation: a Neurophysiology Research Center and Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran.|b Neuroscience Research Center, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Homeira
authors.initials: H
authors.lastname: Zardooz
authors.affiliation: c Department of Biology , College of Basic Sciences, Yadegar-e-Imam Khomeini (RAH) Shahre Rey Branch, Islamic Azad University , Tehran , Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Rostamkhani
authors.affiliation: d Department of Community Medicine , School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran , and.
authors.forename: Alireza
authors.initials: A
authors.lastname: Abadi
authors.affiliation: e Department of Pathology , School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Forough
authors.initials: F
authors.lastname: Foroughi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects*; D004597:Electroshock / Q000009:adverse effects*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D050152:Intra-Abdominal Fat / Q000378:metabolism / Q000473:pathology; D020738:Leptin / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D020738:Leptin
keywords: Corticosterone; free fatty acids; intra-abdominal cow fat; leptin; pancreatic-isolated islets