title: Dysregulation of TMPRSS3 and TNFRSF11B correlates with tumorigenesis and poor prognosis in patients with breast cancer.
abstract: The present study was carried out to investigate the clinical significance of TMPRSS3 and TNFRSF11B in breast cancer. Thus, the expression levels of TMPRSS3 and TNFRSF11B and the correlation with prognosis in patients with breast cancer were analyzed in silico using gene microarray and hierarchical clustering analysis. Then, the differential expression in breast cancer vs. normal breast tissue was explored in the Oncomine platform and verified in our independent samples using IHC technique. Our results indicated that TMPRSS3 was upregulated and TNFRSF11B was downregulated in breast cancer tissues compared with the levels in the human normal breast tissues. TMPRSS3 and TNFRSF11B were confirmed to be correlated with distant organ metastasis of breast cancer. Moreover, upregulation of TMPRSS3 accompanied by downregulation of TNFRSF11B was found to be associated with a shorter median overall survival and indicated a poor prognosis. In conclusion, TMPRSS3 and TNFRSF11B may have potential prognostic value to be used as tumor biomarkers in breast cancer patients.
authors.affiliation: Department of Breast Cancer, Nanchang Third Hospital, Nanchang, Jiangxi 330002, P.R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Luo
authors.affiliation: Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.
authors.forename: Gaixia
authors.initials: G
authors.lastname: Lu
authors.affiliation: Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Fan
authors.affiliation: Department of Radiology, Jiangxi Provincial Tumor Hospital, Nanchang, Jiangxi 330029, P.R. China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zhong
authors.affiliation: Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.
authors.forename: Huiqiong
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.
authors.forename: Ruting
authors.initials: R
authors.lastname: Xie
authors.affiliation: Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Lv
authors.affiliation: Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Qian-Zhou
authors.initials: QZ
authors.lastname: Lv
authors.affiliation: Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.
authors.forename: Da
authors.initials: D
authors.lastname: Fu
authors.affiliation: Department of Thoracic Surgery, Changhai Hospital of Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Yang
authors.affiliation: Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.
authors.forename: Yushui
authors.initials: Y
authors.lastname: Ma
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D063646:Carcinogenesis / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D053244:Osteoprotegerin / Q000096:biosynthesis* / Q000235:genetics; D011379:Prognosis; D012697:Serine Endopeptidases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human; D012697:Serine Endopeptidases; C409042:TMPRSS3 protein, human