title: Impact of Bariatric Surgery on Metabolic and Gut Microbiota Profile: a Systematic Review and Meta-analysis.
abstract: We aim to review the available literature on obese patients treated with bariatric procedures, in order to assess their effect on the metabolic and gut microbiota profiles. A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Twenty-two studies (562 patients) met the inclusion criteria. This study points to significant amelioration of postoperative levels of glucose, insulin, triglycerides, total cholesterol, LDL, HDL, HOMA-IR, food intake, and diabetes remission. Branched-chain amino acids (BCAAs) decreased, while trimethylamine-n-oxide (TMAO); glucagon-like peptide 1, 2 (GLP-1, GLP-2); and peptide YY (PYY) increased postoperatively. Postoperative gut microbiota was similar to that of lean and less obese objects. Well-designed randomized trials are necessary to further assess the host metabolic-microbial cross-talk after bariatric procedures.
authors.affiliation: Department of Surgery, University Hospital of Larissa, Larissa, Greece. dmagouliotis@gmail.com.
authors.forename: Dimitrios E
authors.initials: DE
authors.lastname: Magouliotis
authors.affiliation: School of Health Sciences, Faculty of Medicine, University of Thessaly, Viopolis, Larissa, Greece.
authors.forename: Vasiliki S
authors.initials: VS
authors.lastname: Tasiopoulou
authors.affiliation: Department of Surgery, University Hospital of Larissa, Larissa, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Sioka
authors.affiliation: Department of Microbiology, University Hospital of Larissa, Larissa, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Chatedaki
authors.affiliation: Department of Surgery, University Hospital of Larissa, Larissa, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Zacharoulis
mesh_terms: D000328:Adult; D000597:Amino Acids, Branched-Chain / Q000097:blood / Q000378:metabolism; D050110:Bariatric Surgery; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D005260:Female; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D052216:Glucagon-Like Peptide 1 / Q000097:blood / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism / Q000601:surgery; D055815:Young Adult
chemical_list: D000597:Amino Acids, Branched-Chain; D001786:Blood Glucose; D007328:Insulin; D052216:Glucagon-Like Peptide 1
keywords: AGB; Bariatric surgery; Gut microbiota; Metabolites; RYGB; SG