title: Deciphering the mRNP Code: RNA-Bound Determinants of Post-Transcriptional Gene Regulation.
abstract: Eukaryotic cells determine the final protein output of their genetic program not only by controlling transcription but also by regulating the localization, translation and turnover rates of their mRNAs. Ultimately, the fate of any given mRNA is determined by the ensemble of all associated RNA-binding proteins (RBPs), non-coding RNAs and metabolites collectively known as the messenger ribonucleoprotein particle (mRNP). Although many mRNA-associated factors have been identified over the past years, little is known about the composition of individual mRNPs and the cooperation of their constituents. In this review we discuss recent progress that has been made on how this 'mRNP code' is established on individual transcripts and how it is interpreted during gene expression in eukaryotic cells.
authors.affiliation: Institute for Genetics, University of Cologne, Germany. Electronic address: ngehring@uni-koeln.de.
authors.forename: Niels H
authors.initials: NH
authors.lastname: Gehring
authors.affiliation: Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Germany.
authors.forename: Elmar
authors.initials: E
authors.lastname: Wahle
authors.affiliation: Theodor-Boveri Institute, University of Wuerzburg, Germany. Electronic address: utz.fischer@biozentrum.uni-wuerzburg.de.
authors.forename: Utz
authors.initials: U
authors.lastname: Fischer
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D011499:Protein Processing, Post-Translational / Q000235:genetics*; D012313:RNA / Q000235:genetics* / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000235:genetics* / Q000378:metabolism*
chemical_list: D012261:Ribonucleoproteins; C026452:messenger ribonucleoprotein; D012313:RNA