title: Effect of ventilator mode on patient-ventilator synchrony and work of breathing in neonatal pigs.
abstract: Patient-ventilator asynchrony can result in increased work of breathing (WOB) and need for increased sedation, as well as respiratory muscle fatigue and prolonged mechanical ventilation. Different ventilator modes may result in varying degrees of asynchrony and WOB.
  
  
  
  The objectives of this study were to assess the incidence of asynchrony and the effect of asynchrony on WOB in three modes of ventilation: pressure regulated volume control (PRVC), synchronized intermittent mandatory ventilation/volume control plus pressure support (SIMV/VC plus PS), and SIMV/PRVC plus PS.
  
  
  
  Ten piglets (2.1 ± 0.3 kg) were studied, each in the healthy and surfactant-depleted, lung-injured state. Piglets were sedated, intubated, and ventilated with the three modes of ventilation randomly applied. Piglets then underwent surfactant washout, after which the lungs were re-recruited, and the modes of ventilation were repeated. Airway flow and pressure waveforms were acquired via pneumotachograph. Waveforms were analyzed for patient-ventilator asynchrony and pressure time product (PTP) as an estimate of patient WOB. RESULTS SIMV/VC plus PS had the highest incidence of asynchrony. The incidence of asynchrony was less in the injured lung. PTP (cm H2O*S) was increased for SIMV/VC plus PS (healthy 0.10 ± 0.12; injured 0.15 ± 0.13) compared to PRVC (healthy 0.05 ± 0.05; injured 0.06 ± 0.03), (P < 0.03) in both the healthy and injured lung models.
  
  
  
  Asynchrony and WOB are highest with SIMV/VC plus PS. If SIMV is utilized, SIMV/PRVC plus a PS that optimizes tidal volume may be preferable. PRVC has the least asynchrony and WOB in the injured lung.
authors.affiliation: Baptist Health Medical Center, Little Rock, Arkansas.
authors.forename: Shayna M
authors.initials: SM
authors.lastname: Wood
authors.affiliation: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Thurman
authors.affiliation: Arkansas Children's Hospital, Little Rock, Arkansas.
authors.forename: Shirley J
authors.initials: SJ
authors.lastname: Holt
authors.affiliation: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors.forename: Shasha
authors.initials: S
authors.lastname: Bai
authors.affiliation: Spence and Becky Wilson Baptist Children's Hospital, Memphis, Tennessee.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Heulitt
authors.affiliation: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors.forename: Sherry E
authors.identifier: 0000-0003-1180-6598
authors.initials: SE
authors.lastname: Courtney
mesh_terms: D000818:Animals; D008297:Male; D011663:Pulmonary Surfactants; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods*; D013552:Swine; D013990:Tidal Volume / Q000502:physiology; D055397:Ventilator-Induced Lung Injury / Q000503:physiopathology*; D014939:Work of Breathing / Q000502:physiology*
chemical_list: D011663:Pulmonary Surfactants
keywords: mechanical ventilation; patient-ventilator asynchrony; synchronized intermittent mandatory ventilation; work of breathing