title: Prions and the concept of polyprionic inheritance.
abstract: Discovery of prions-proteins that are able to convert between structurally distinct states, of which one or more is transmissible, led to the concept of "protein-based inheritance". According to this concept, the formation of prion fibrils causes DNA-independent heritable traits in microorganisms. Recently, we described a new and unusual type of prion inheritance. We showed that the yeast prions [PIN+] and [SWI+], like classical genes, demonstrate complementary interaction that causes a phenotypic change in yeast cells. Here, we discuss the possible mechanisms of such polyprionic inheritance and the perspectives in the identification of prions in various organisms using universal proteomic approaches.
authors.affiliation: Vavilov Institute of General Genetics, St. Petersburg Branch, Russian Academy of Sciences, 199034, St. Petersburg, Russian Federation. apgalkin@mail.ru.|Department of Genetics and Biotechnology, St. Petersburg State University, 199034, St. Petersburg, Russian Federation. apgalkin@mail.ru.
authors.forename: Alexey P
authors.initials: AP
authors.lastname: Galkin
mesh_terms: D000682:Amyloid / Q000235:genetics / Q000378:metabolism; D000818:Animals; D006801:Humans; D040582:Inheritance Patterns; D011328:Prions / Q000235:genetics* / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D000682:Amyloid; D011328:Prions
keywords: Amyloid; Polyprionic inheritance; Prion; Proteomic screen; Yeast