title: Comparative Effectiveness Trials of Imaging-Guided Strategies in Stable Ischemic Heart Disease.
abstract: The evaluation of patients with suspected stable ischemic heart disease is among the most common diagnostic evaluations with nearly 20 million imaging and exercise stress tests performed annually in the United States. Over the past decade, there has been an evolution in imaging research with an ever-increasing focus on larger registries and randomized trials comparing the effectiveness of varying diagnostic algorithms. The current review highlights recent randomized trial evidence with a particular focus comparing the effectiveness of cardiac imaging procedures within the stable ischemic heart disease evaluation for coronary artery disease detection, angina, and other quality of life measures, and major clinical outcomes. Also highlighted are secondary analyses from these trials on the economic findings related to comparative cost differences across diagnostic testing strategies.
authors.affiliation: Emory University School of Medicine, Atlanta, Georgia. Electronic address: lshaw3@emory.edu.
authors.forename: Leslee J
authors.initials: LJ
authors.lastname: Shaw
authors.affiliation: New York University Langone Medical Center, New York City, New York.
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: Phillips
authors.affiliation: Institute for Experimental and Translational Cardiovascular Imaging, DZHK Centre for Cardiovascular Imaging, University Hospital Frankfurt, Frankfurt am Main, Germany.
authors.forename: Eike
authors.initials: E
authors.lastname: Nagel
authors.affiliation: University of Edinburgh, Edinburgh, Scotland.
authors.forename: David E
authors.initials: DE
authors.lastname: Newby
authors.affiliation: Mount Sinai School of Medicine, New York City, New York.
authors.forename: Jagat
authors.initials: J
authors.lastname: Narula
authors.affiliation: Duke Clinical Research Institute, Durham, North Carolina.
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Douglas
mesh_terms: D057791:Cardiac Imaging Techniques / Q000191:economics; D057186:Comparative Effectiveness Research / Q000379:methods*; D003362:Cost-Benefit Analysis; D017048:Health Care Costs; D006801:Humans; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000191:economics / Q000628:therapy*; D011237:Predictive Value of Tests; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design; D016896:Treatment Outcome
keywords: cardiac imaging; diagnostic testing; randomized trials; stable ischemic heart disease