title: Clinical and neuroimaging characteristics of Chinese dementia with Lewy bodies.
abstract: Dementia with Lewy bodies (DLB) is the second most common subtype of degenerative dementia. To our knowledge, available information about the clinical features of DLB in China remains limited. Our study therefore aimed to address this issue. Thirty-seven Chinese patients with probable DLB were recruited for this study. All subjects underwent neuropsychological assessment by trained neurologists, as well as undergoing MRI, 11C-PIB PET scans for Aβ deposition and 18F-FDG PET scans for regional cerebral glucose metabolism. Our results showed that the gender ratio of patients was 16:21 (F:M). The mean age of onset was 69.5 ± 9.0 years and the mean age at diagnosis was 71.8 ± 9.1 years. At diagnosis, the prevalence of three core clinical features of DLB was: 64.9% for fluctuating cognition, 73.0% for visual hallucinations and 62.2% for parkinsonism. The result from 11C-PiB PET and 18F-FDG PET scans confirmed Aβ deposition in the cortex and demonstrated hypometabolism in the bilateral temporoparietooccipital region, the frontal lobe, the insular lobe, and the posterior cingulate, precuneus and caudate nuclei. Our study elucidated the clinical features of Chinese DLB patients, and will improve the understanding and the early diagnosis of DLB in Chinese patients.
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.|Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.|Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Xiao-Dan
authors.initials: XD
authors.lastname: Wang
authors.affiliation: PET-CT Center, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.|Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Shi
authors.affiliation: PET-CT Center, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Li
authors.initials: L
authors.lastname: Cai
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.|Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Shuling
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Radiology, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Han
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.|Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.|Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Xinping
authors.initials: X
authors.lastname: Wang
authors.affiliation: PET-CT Center, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.|Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ji
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000814:Aniline Compounds; D052160:Benzothiazoles / Q000378:metabolism; D001692:Biological Transport; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D002681:China; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D020961:Lewy Body Disease / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D049268:Positron-Emission Tomography; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D052160:Benzothiazoles; D013844:Thiazoles; D019788:Fluorodeoxyglucose F18; D005947:Glucose