title: Understanding the Snake Venom Metalloproteinases: An Interview with Jay Fox and José María Gutiérrez.
abstract: Jay W. Fox and José María Gutiérrez recently finished editing a Special Issue on the topic "Snake Venom Metalloproteinases" inToxins. The Special Issue covers a wide range of topics, including the molecular evolution and structure of snake venom metalloproteinases (SVMPs), the mechanisms involved in the generation of diversity of SVMPs, the mechanism of action of SVMPs, and their role in the pathophysiology of envenomings, with implications for improving the therapy of envenomings. In this interview, we discussed with Jay W. Fox and José María Gutiérrez their research on the SVMPs and their perspectives on the future trends and challenges for studying snake venoms.
authors.affiliation: Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, P.O. Box 800734, Charlottesville, VA 22908, USA. jwf8x@virginia.edu.
authors.forename: Jay W
authors.initials: JW
authors.lastname: Fox
authors.affiliation: Instituto Clodomiro Picado, Facultad de Microbiología Universidad de Costa Rica, San José 11501-2060, Costa Rica. jose.gutierrez@ucr.ac.cr.
authors.forename: José María
authors.initials: JM
authors.lastname: Gutiérrez
mesh_terms: D035843:Biomedical Research / Q000266:history; D002321:Career Choice; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D045726:Metalloproteases / Q000266:history / Q000378:metabolism*; D030162:Reptilian Proteins / Q000266:history / Q000378:metabolism*; D012909:Snake Bites / Q000201:enzymology* / Q000266:history; D012910:Snake Venoms / Q000201:enzymology* / Q000266:history
chemical_list: D030162:Reptilian Proteins; D012910:Snake Venoms; D045726:Metalloproteases