title: The role of APOE on lipid homeostasis and inflammation in normal brains.
abstract: The role of APOE in the risk of Alzheimer's disease (AD) has largely focused on its effects on AD pathological processes. However, there are increasing data thatAPOEgenotype affects processes in normal brains. Studies of young cognitively normal humans show effects ofAPOEgenotype on brain structure and activity. Studies of normalAPOEknock-in mice show effects ofAPOEgenotype on brain structure, neuronal markers, and behavior. APOE interactions with molecules important for lipid efflux and lipid endocytosis underlie effects ofAPOEgenotype on neuroinflammation and lipoprotein composition. These effects provide important targets for new therapies for reduction of the risk of AD before any signs of pathogenesis.
authors.affiliation: Department of Neuroscience, Georgetown University Medical Center, Washington, DC. Electronic address: gwr2@georgetown.edu.
authors.forename: G William
authors.initials: GW
authors.lastname: Rebeck
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism*; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D005838:Genotype; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism
chemical_list: D001057:Apolipoproteins E
keywords: ATP binding cassette transporter A1; Alzheimer’s disease; apolipoprotein E; apolipoproteins; inflammation; lipids/efflux