title: Imaging of Prostate Cancer Using Urokinase-Type Plasminogen Activator Receptor PET.
abstract: Urokinase-type plasminogen activator receptor (uPAR) overexpression is an important biomarker for aggressiveness in cancer including prostate cancer (PC) and provides independent clinical information in addition to prostate-specific antigen and Gleason score. This article focuses on uPAR PET as a new diagnostic and prognostic imaging biomarker in PC. Many preclinical uPAR-targeted PET imaging studies using AE105 in cancer models have been undertaken with promising results. A major breakthrough was obtained with the recent human translation of uPAR PET in using64Cu- and68Ga-labelled versions of AE105, respectively. Clinical results from patients with PC included in these studies are encouraging and support continuation with large-scale clinical trials.
authors.affiliation: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 9, 4011, Copenhagen, DK-2100, Denmark.
authors.forename: Dorthe
authors.initials: D
authors.lastname: Skovgaard
authors.affiliation: Curasight Aps, Ole Maaloesvej 3, Copenhagen, DK-2200, Denmark.
authors.forename: Morten
authors.initials: M
authors.lastname: Persson
authors.affiliation: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 9, 4011, Copenhagen, DK-2100, Denmark. Electronic address: akjaer@sund.ku.dk.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kjaer
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005710:Gallium Radioisotopes; D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; D006801:Humans; D008297:Male; D051379:Mice; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D055293:Receptors, Urokinase Plasminogen Activator / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D005710:Gallium Radioisotopes; D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; D019275:Radiopharmaceuticals; D055293:Receptors, Urokinase Plasminogen Activator; C048993:1,4,7-triazacyclononane-N,N',N''-triacetic acid
keywords: Molecular imaging; PET; Prostate cancer; Radionuclide imaging; Theranostics; uPAR