title: Proteasomes on the chromosome.
abstract: Targeted proteolysis plays an important role in the execution and regulation of many cellular events. Two recent papers in Science identify novel roles for proteasome-mediated proteolysis in homologous chromosome pairing, recombination, and segregation during meiosis.
authors.affiliation: Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MA 20892-4260, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Lichten
mesh_terms: D023902:Chromosome Pairing; D002875:Chromosomes; D008540:Meiosis; D046988:Proteasome Endopeptidase Complex; D011995:Recombination, Genetic
chemical_list: D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease