title: Distribution of invariant natural killer T cells and dendritic cells in late pre-term birth without acute chorioamnionitis.
abstract: Acute chorioamnionitis (aCAM) is an important cause of pre-term birth. However, little is known about the pathogenesis of late pre-term birth without aCAM that was the most common category of pre-term birth. Here we analyze the kinetics of immune cells obtained from the decidua of women with late pre-term births with and without aCAM.
  
  
  
  Deciduas were obtained from women who underwent labor with late pre-term birth without aCAM (PB-n/aCAM) or with aCAM (PB-w/aCAM). The population of DEC-205+dendritic cells (DCs), macrophages, invariant natural killer T (iNKT) cells, NK cells, CD8+T cells, and CD4+T cells were analyzed by flow cytometry.
  
  
  
  The number of iNKT cells was higher in the decidua obtained from women with PB-n/aCAM than PB-w/aCAM. DEC-205+DCs obtained from women with PB-n/aCAM preferentially induced iNKT cell proliferation.
  
  
  
  iNKT cell accumulation with DEC-205+DCs in PB-n/aCAM suggests that iNKT cells contribute to the onset of PB-n/aCAM.
authors.affiliation: Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan.|Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Negishi
authors.affiliation: Department of Pediatrics, Nippon Medical School Musashikosugi Hospital, Kanagawa, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Shima
authors.affiliation: Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takeshita
authors.affiliation: Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan.
authors.forename: Hidemi
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D015703:Antigens, CD / Q000276:immunology; D002821:Chorioamnionitis / Q000276:immunology; D003656:Decidua / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D037181:Lectins, C-Type / Q000276:immunology; D015778:Minor Histocompatibility Antigens / Q000276:immunology; D055611:Natural Killer T-Cells / Q000276:immunology*; D011247:Pregnancy; D047928:Premature Birth / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology
chemical_list: D015703:Antigens, CD; C093569:DEC-205 receptor; D037181:Lectins, C-Type; D015778:Minor Histocompatibility Antigens; D011956:Receptors, Cell Surface
keywords: DEC-205; NK cell; innate immunity