title: Automated detection of dilated capillaries on optical coherence tomography angiography.
abstract: Automated detection and grading of angiographic high-risk features in diabetic retinopathy can potentially enhance screening and clinical care. We have previously identified capillary dilation in angiograms of the deep plexus in optical coherence tomography angiography as a feature associated with severe diabetic retinopathy. In this study, we present an automated algorithm that uses hybrid contrast to distinguish angiograms with dilated capillaries from healthy controls and then applies saliency measurement to map the extent of the dilated capillary networks. The proposed algorithm agreed well with human grading.
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA; College of Information Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China.
authors.forename: Changlei
authors.initials: C
authors.lastname: Dongye
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA; OptoVue, Inc., 2800 Bayview Dr, Fremont, CA 94538, USA.
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Hwang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Simon S
authors.initials: SS
authors.lastname: Gao
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: David
authors.initials: D
authors.lastname: Huang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Wilson
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Yali
authors.initials: Y
authors.lastname: Jia
keywords: (100.0100) Image processing; (100.2960) Image analysis; (110.4500) Optical coherence tomography; (170.3880) Medical and biological imaging; (170.4470) Ophthalmology