title: Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series.
abstract: No studies to date have prospectively examined early autism spectrum disorder (ASD) markers in infants with fragile X syndrome (FXS), who are at elevated risk for ASD. This paper describes the developmental profiles of eight infants with FXS from 9 to 24 months of age. Four meet diagnostic criteria for ASD at 24 months of age, and four do not. Trends in these case studies suggest that early social-communicative deficits differentiate infants with and without later ASD diagnoses in ways that are similar to later-born siblings of children with ASD. Repetitive behaviors and cognitive and adaptive impairments are present in all FXS infants throughout development, suggesting that these deficits reflect the general FXS phenotype and not ASD in FXS specifically.
authors.affiliation: Department of Psychology, University of South Carolina, 1512 Pendleton Street, Barnwell College, Suite 220, Columbia, SC, 29208, USA. hogan@sc.edu.
authors.forename: Abigail L
authors.initials: AL
authors.lastname: Hogan
authors.affiliation: Department of Psychology, University of South Carolina, 1512 Pendleton Street, Barnwell College, Suite 220, Columbia, SC, 29208, USA.
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Caravella
authors.affiliation: Department of Psychology, University of South Carolina, 1512 Pendleton Street, Barnwell College, Suite 220, Columbia, SC, 29208, USA.
authors.forename: Jordan
authors.initials: J
authors.lastname: Ezell
authors.affiliation: Department of Psychology, University of South Carolina, 1512 Pendleton Street, Barnwell College, Suite 220, Columbia, SC, 29208, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Rague
authors.affiliation: Department of Psychology, University of South Carolina, 1512 Pendleton Street, Barnwell College, Suite 220, Columbia, SC, 29208, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Hills
authors.affiliation: Department of Psychology, University of South Carolina, 1512 Pendleton Street, Barnwell College, Suite 220, Columbia, SC, 29208, USA.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Roberts
mesh_terms: D000067877:Autism Spectrum Disorder / Q000150:complications / Q000175:diagnosis* / Q000523:psychology*; D002675:Child, Preschool; D003142:Communication; D005260:Female; D005600:Fragile X Syndrome / Q000150:complications / Q000175:diagnosis* / Q000523:psychology*; D006801:Humans; D007223:Infant; D018730:Infant Behavior / Q000523:psychology*; D008297:Male; D011446:Prospective Studies
keywords: Autism spectrum disorder; Case studies; Fragile X syndrome; Infants