title: Computational modeling of radiobiological effects in bone metastases for different radionuclides.
abstract: Computational simulation is a simple and practical way to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aimed to evaluate and compare cellular effects modelled for different radioisotopes currently in use or under research for treatment of bone metastases using computational methods.
  
  
  
  Computational models were used to estimate the radiation-induced cellular effects (Virtual Cell Radiobiology algorithm) post-irradiation with selected particles emitted by Strontium-89 (89Sr), Samarium-153 (153Sm), Lutetium-177 (177Lu), and Radium-223 (223Ra).
  
  
  
  Cellular kinetics post-irradiation using89Sr β-particles,153Sm β-particles,177Lu β-particles and223Ra α particles showed that the cell response was dose- and radionuclide-dependent.177Lu beta minus particles and, in particular,223Ra alpha particles, yielded the lowest survival fraction of all investigated particles.
  
  
  
  223Ra alpha particles induced the highest cell death of all investigated particles on metastatic prostate cells in comparison to irradiation with β-radionuclides, two of the most frequently used radionuclides in the palliative treatment of bone metastases in clinical routine practice. Moreover, the data obtained suggest that the used computational methods might provide some perception about cellular effects following irradiation with different radionuclides.
authors.affiliation: a Faculdade de Engenharia , Instituto de Ciência e Inovação em Engenharia Mecânica e Engenharia Industrial, Universidade do Porto , Porto , Portugal.
authors.forename: Francisco D C Guerra
authors.initials: FDCG
authors.lastname: Liberal
authors.affiliation: a Faculdade de Engenharia , Instituto de Ciência e Inovação em Engenharia Mecânica e Engenharia Industrial, Universidade do Porto , Porto , Portugal.
authors.forename: Adriana Alexandre S
authors.initials: AAS
authors.lastname: Tavares
authors.affiliation: a Faculdade de Engenharia , Instituto de Ciência e Inovação em Engenharia Mecânica e Engenharia Industrial, Universidade do Porto , Porto , Portugal.
authors.forename: João Manuel R S
authors.initials: JMRS
authors.lastname: Tavares
mesh_terms: D001859:Bone Neoplasms / Q000503:physiopathology / Q000532:radiotherapy* / Q000556:secondary*; D002470:Cell Survival / Q000528:radiation effects*; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008954:Models, Biological; D011868:Radioisotopes / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*
chemical_list: D011868:Radioisotopes
keywords: Computational simulation; Lutetium-177; Radium-223; bone metastases; radiation-induced effects