title: Effect of Cruciferous Vegetable Intake on Oxidative Stress Biomarkers: Differences by Breast Cancer Status.
abstract: This post hoc analysis examined cruciferous vegetable intake on urinary oxidative metabolites in postmenopausal women. Intervention participants (n = 69) received cruciferous vegetables (≥14 cups/week) during a 3-week period. First morning urine measured 8-isoprostane and 8-hydroxy-2'-deoxyguanosine. Dietary intake was estimated using 24-h recalls. When stratified by history of breast cancer, those with breast cancer had significantly lower post-intervention urinary 8-hydroxy-2'-deoxyguanosine values in the intervention arm versus. the control arm (1.1 ng/mL vs. 3.2 ng/mL, p = .01) after adjustment for baseline 8-hydroxy-2'-deoxyguanosine. This was not observed in those without breast cancer. Further work is needed to understand the role of breast cancer in these relationships.
authors.affiliation: a Department of Epidemiology and Biostatistics , Arnold School of Public Health, University of South Carolina , Columbia , South Carolina , USA.|b Cancer Prevention and Control Program , University of South Carolina , Columbia , South Carolina , USA.|c Connecting Health Innovation, LLC , Columbia , South Carolina , USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Wirth
authors.affiliation: d Department of Pathology , Microbiology, and Immunology, School of Medicine, University of South Carolina , Columbia , South Carolina , USA.
authors.forename: E Angela
authors.initials: EA
authors.lastname: Murphy
authors.affiliation: c Connecting Health Innovation, LLC , Columbia , South Carolina , USA.
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Hurley
authors.affiliation: a Department of Epidemiology and Biostatistics , Arnold School of Public Health, University of South Carolina , Columbia , South Carolina , USA.|b Cancer Prevention and Control Program , University of South Carolina , Columbia , South Carolina , USA.|c Connecting Health Innovation, LLC , Columbia , South Carolina , USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Hébert
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D014408:Biomarkers, Tumor / Q000652:urine*; D001937:Brassica; D001943:Breast Neoplasms / Q000178:diet therapy* / Q000652:urine*; D016022:Case-Control Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D004032:Diet; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D014408:Biomarkers, Tumor; C075750:8-epi-prostaglandin F2alpha; D000080242:8-Hydroxy-2'-Deoxyguanosine; D015237:Dinoprost; D003849:Deoxyguanosine
keywords: Cruciferous vegetables; breast cancer; diet; urine lipoprotein oxidation