title: Six new C-21 steroidal glycosides from Dregea sinensis Hemsl.
abstract: Six new C-21 steroidal glycosides (1-6) were separated from the root of Dregea sinensis Hemsl. and their structures were elucidated using extensive nuclear magnetic resonance, mass spectrometry, and infrared spectral analyses. Isolated compounds were evaluated for antitumor activity, which showed that compound 3 had moderate activity in Jurkat cells (IC5019.54 ± 0.91 μM), and compounds 1-4 had significant effects against IL-2R and TNFR2 (IC501.518 ± 0.06 μM to 5.9 ± 0.07 μM).
authors.affiliation: a School of Life Science , Beijing Institute of Technology , Beijing 100081 , China.
authors.forename: Xiu-Jie
authors.initials: XJ
authors.lastname: Liu
authors.affiliation: b School of Basic Medical Sciences , Shanxi Medical University , Taiyuan 030001 , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Shi
authors.affiliation: a School of Life Science , Beijing Institute of Technology , Beijing 100081 , China.
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Jia
authors.affiliation: a School of Life Science , Beijing Institute of Technology , Beijing 100081 , China.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Deng
authors.affiliation: a School of Life Science , Beijing Institute of Technology , Beijing 100081 , China.
authors.forename: Fang
authors.initials: F
authors.lastname: Lv
authors.affiliation: a School of Life Science , Beijing Institute of Technology , Beijing 100081 , China.
authors.forename: Rong-Ji
authors.initials: RJ
authors.lastname: Dai
mesh_terms: D029062:Apocynaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D015375:Receptors, Interleukin-2 / Q000187:drug effects
chemical_list: D006027:Glycosides; D010840:Phytosterols; D015375:Receptors, Interleukin-2
keywords: C-21 steroidal glycosides; Dregea sinensis; anticancer activity; structure–activity relationship