title: Maternal and paternal occupational exposures and hepatoblastoma: results from the HOPE study through the Children's Oncology Group.
abstract: Little is known about the etiology of hepatoblastoma. We aimed to confirm the results of a previous study evaluating the association between parental occupational exposures and hepatoblastoma. In our case-control study, we identified cases (n=383) from the Children's Oncology Group and controls from birth certificates (n=387), which were frequency matched to cases on year and region of birth, sex, and birth weight. Occupational exposure in the year before and during the index pregnancy was collected through maternal interview and analyzed using unconditional logistic regression. The odds of both paternal and maternal "Likely" exposure to paints was elevated among cases compared with controls (paternal odds ratio (OR): 1.71, 95% confidence interval (CI): 1.04, 2.81; maternal OR: 3.29, 95% CI: 0.32, 33.78) after adjustment for matching factors and the confounding factors of maternal race (maternal only) and household income. In addition, paternal exposure to other chemicals was also elevated when adjusting for matching factors only (OR: 1.53, 95% CI: 1.02, 2.30). The results of our study provide further evidence of an association between parental occupation and hepatoblastoma. These results warrant further investigation of the etiologically relevant timing of occupational exposure to fumes and chemicals related to hepatoblastoma.
authors.affiliation: Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Janitz
authors.affiliation: Environmental Health and Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
authors.forename: Gurumurthy
authors.initials: G
authors.lastname: Ramachandran
authors.affiliation: Department of Pediatrics, Greehey Children's Cancer Research Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
authors.forename: Gail E
authors.initials: GE
authors.lastname: Tomlinson
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Krailo
authors.affiliation: Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Michaela
authors.initials: M
authors.lastname: Richardson
authors.affiliation: Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Logan
authors.initials: L
authors.lastname: Spector
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002173:Cancer Care Facilities; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005742:Gasoline / Q000009:adverse effects; D018197:Hepatoblastoma / Q000139:chemically induced*; D006801:Humans; D007223:Infant; D007407:Interviews as Topic; D008113:Liver Neoplasms / Q000139:chemically induced*; D016015:Logistic Models; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects*; D010150:Paint / Q000009:adverse effects*; D018812:Paternal Exposure / Q000009:adverse effects*; D012042:Registries; D012307:Risk Factors; D012997:Solvents / Q000009:adverse effects; D014481:United States; D055815:Young Adult
chemical_list: D005742:Gasoline; D012997:Solvents