title: [Impact of atmospheric particulate matter at different period of gestation on low birth weight: a meta-analysis].
abstract: Objective:To analyze the influence of atmospheric particulate matters (PM(2.5) and PM(10)) on low-birth-weight (LBW) infants at different periods of gestation.Methods:We conducted a systematic literature search for 2 471 articles related to particulate matter and LBW published from January 1st 2000 to January 1st 2016 using the PubMed, Cochrane Library, Web of Science, Science Direct, Chinese Web of Knowledge, Wanfang and Weipu, and the keywords were" air pollution" , "adverse birth outcomes" , "adverse pregnancy outcomes" , "low birth weight/LBW" . According to criteria, 27 literatures were selected and included. Metafor package of the R 3.1.1 Software was used to check the heterogeneity and merge the effect value of the selected literatures, and sensitivity analysis and publication bias were detected and adjusted.Results:A total of 2 471 studies selected form the databases, 27 enrolled in this analysis according to the inclusion and exclusion criteria. Each 10 μg/m(3) increase in PM(2.5) was associated with combinedORvalues of 1st trimester, 2nd trimester, 3rd trimester and entire gestation at 1.02(95% CI:0.87-1.19), 1.03 (95% CI:0.91-1.16) , 1.07 (95%CI:1.04-1.11) and 1.09 (95%CI:1.04-1.15), respectively. And 10 μg/m(3) increase in PM(10) was associated with combinedORvalues of 1st trimester, 2nd trimester, 3rd trimester and entire gestation at 1.66 (95%CI:1.06-2.61), 1.58 (95%CI:1.28-1.95) , 1.38 (95%CI:1.23-1.56) and 1.04 (95%CI:0.99-1.09), respectively. After adjusting the bias of publication, each 10 μg/m(3) increase in PM(2.5) was associated with the risk of low birth weight at 1.11 (95%CI: 1.02-1.21).Conclusion:This meta analysis supports an adverse impact of maternal exposure to particulate air pollution on low birth weight, varying in effects by exposure period.
authors.affiliation: School of Public Health, Wuhan University, Wuhan 430071, China.
authors.forename: R J
authors.initials: RJ
authors.lastname: Feng
authors.forename: R
authors.initials: R
authors.lastname: Wu
authors.forename: P R
authors.initials: PR
authors.lastname: Zhong
authors.forename: X J
authors.initials: XJ
authors.lastname: Tian
authors.forename: X
authors.initials: X
authors.lastname: Long
authors.forename: C F
authors.initials: CF
authors.lastname: Fan
authors.forename: L
authors.initials: L
authors.lastname: Ma
mesh_terms: D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D000397:Air Pollution / Q000706:statistics & numerical data; D001724:Birth Weight; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D018811:Maternal Exposure; D052638:Particulate Matter / Q000032:analysis / Q000633:toxicity*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D012306:Risk
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter
keywords: Gestation window phase; Low birth weight; Maternal; Meta-analysis; Particulate matter