title: Simultaneous determination of sodium saccharin, aspartame, acesulfame-K and sucralose in food consumed in Korea using high-performance liquid chromatography and evaporative light-scattering detection.
abstract: Four artificial sweeteners, i.e., sodium saccharin, aspartame, acesulfame-K and sucralose, are permitted for use in Korea, and recent regulatory changes have expanded the number of food categories in which they may be used. Four artificial sweeteners were determined simultaneously in more than 900 food items from 30 food categories that are commercially available in Korean markets, including both domestic and imported products, using high-performance liquid chromatography and evaporative light-scattering detection (ELSD). A new procedure using 75% acetone to remove fat was applied for sample preparation. The levels detected in all samples were below the maximum permitted use levels established in Korea. Despite the increased number of categories, the only one in which sodium saccharin was newly found was takju, an alcoholic beverage. Sodium saccharin was not found in other beverages in the food analysis or in the food label survey, even though its use was reported in a previous study, suggesting that consumer preference outweighs regulatory decisions. When the analytical results were combined with food-consumption data obtained from the Korea National Health and Nutrition Examination Survey 2010-14, the estimated daily intakes of all the sweeteners were considered safe.
authors.affiliation: a Department of Food and Nutrition , Seoul National University , Seoul , Korea.
authors.forename: Youngsun
authors.initials: Y
authors.lastname: Lee
authors.affiliation: a Department of Food and Nutrition , Seoul National University , Seoul , Korea.
authors.forename: Byungkyung
authors.initials: B
authors.lastname: Do
authors.affiliation: b Food Additives and Packaging Division , Ministry of Food and Drug Safety , Cheongju-si , Korea.
authors.forename: Gunyoung
authors.initials: G
authors.lastname: Lee
authors.affiliation: b Food Additives and Packaging Division , Ministry of Food and Drug Safety , Cheongju-si , Korea.
authors.forename: Ho Soo
authors.initials: HS
authors.lastname: Lim
authors.affiliation: b Food Additives and Packaging Division , Ministry of Food and Drug Safety , Cheongju-si , Korea.
authors.forename: Sang Soon
authors.initials: SS
authors.lastname: Yun
authors.affiliation: a Department of Food and Nutrition , Seoul National University , Seoul , Korea.|c Research Institute of Human Ecology , Seoul National University , Seoul , Korea.
authors.forename: Hoonjeong
authors.initials: H
authors.lastname: Kwon
mesh_terms: D001218:Aspartame / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D000067493:Dynamic Light Scattering; D005504:Food Analysis; D006801:Humans; D056910:Republic of Korea; D012439:Saccharin / Q000032:analysis* / Q000737:chemistry*; D013395:Sucrose / Q000031:analogs & derivatives* / Q000032:analysis; D013843:Thiazines / Q000032:analysis*; D014835:Volatilization
chemical_list: D013843:Thiazines; D013395:Sucrose; C026285:trichlorosucrose; D012439:Saccharin; C006362:acetosulfame; D001218:Aspartame
keywords: ELSD; Sodium saccharin; acesulfame-K; aspartame; simultaneous analysis; sucralose