title: Can ischemia-modified albumin be used to differentiate between generalized seizures and pseudoseizures?
abstract: In recent years ischemia-modified albumin (IMA) has been suggested as a marker that can be used in differentiating nonconvulsive conditions from epilepsy. The purpose of this study was to investigate changes in IMA levels caused by generalized clonic tonic (GTC) seizures.
  
  
  
  A total of 114 children presenting to the Karadeniz Technical Pediatric Emergency Polyclinic with GTC seizures were included in the study. Sixteen cases meeting the inclusion criteria were included in the study and sixteen healthy children were enrolled as the control group. The patients' IMA, albumin, and IMA/albumin values at hours 0 and 1 following the episode were compared with control group values.
  
  
  
  IMA levels in the patient group were significantly higher at hour 1 compared to hour 0, and were also significantly higher than those of the control group levels at hour 1. In addition, the patient group IMA/albumin index value at hour 1 was significantly higher than the baseline value. IMA levels increased significantly with length of seizure.
  
  
  
  Although there were no markers of hypoxia in patients undergoing GTC seizures in this study, hypoxia was observed to develop, and this caused serum IMA levels to rise in line with seizure duration.
authors.affiliation: Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Tülay
authors.initials: T
authors.lastname: Kamaşak
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Türedi
authors.affiliation: Children's Hospital, Adana, Turkey.
authors.forename: Hepsen Mine
authors.initials: HM
authors.lastname: Serin
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Menteşe
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Abdülkadir
authors.initials: A
authors.lastname: Gündüz
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alver
authors.affiliation: Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Cansu
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D003937:Diagnosis, Differential; D004830:Epilepsy, Tonic-Clonic / Q000097:blood / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D012640:Seizures / Q000097:blood* / Q000175:diagnosis*; D000075462:Serum Albumin, Human
chemical_list: D015415:Biomarkers; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human