title: Patterns of brain atrophy associated with episodic memory and semantic fluency decline in aging.
abstract: The cerebral substratum of age-related cognitive decline was evaluated in an elderly-cohort followed for 12 years (n=306). Participants, free of dementia, received neuropsychological assessments every two years and an MRI exam at baseline and four years later. Cognitive decline was evaluated on two broadly used tests to detect dementia: the Free and Cued Selective Reminding Test (FCSRT), a verbal episodic memory task, and the Isaacs Set Test (IST), a semantic fluency task. Using voxel-based approach, the relationship between cognitive decline with 1/ baseline grey matter volumes and 2/ grey matter volume loss between the two scans was explored. Baseline volumes analysis revealed that FCSRT and IST declines were both associated with lower volumes of the medial temporal region. Volumes loss analysis confirmed that both declines are related to medial temporal lobe atrophy and revealed that FCSRT decline was specifically associated with atrophy of the posterior cingulate cortex whereas IST decline was specifically related to temporal pole atrophy. These results suggest that cognitive decline across aging is firstly related to structural modifications of the medial temporal lobe, followed by an atrophy in the posterior midline structures for episodic memory and an atrophy of the temporal pole for semantic fluency.
authors.affiliation: University Bordeaux, ISPED, Centre INSERM U1219, F-33000 Bordeaux, France.|INSERM, ISPED, Centre INSERM U1219, F-33000 Bordeaux, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Pelletier
authors.affiliation: University Bordeaux, INCIA, UMR 5287, F-33000 Bordeaux, France.|CNRS, INCIA, UMR 5287, F-33000 Bordeaux, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Bernard
authors.affiliation: University Bordeaux, INCIA, UMR 5287, F-33000 Bordeaux, France.|CNRS, INCIA, UMR 5287, F-33000 Bordeaux, France.
authors.forename: Bixente
authors.initials: B
authors.lastname: Dilharreguy
authors.affiliation: University Bordeaux, ISPED, Centre INSERM U1219, F-33000 Bordeaux, France.|INSERM, ISPED, Centre INSERM U1219, F-33000 Bordeaux, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Helmer
authors.affiliation: University Bordeaux, ISPED, Centre INSERM U1219, F-33000 Bordeaux, France.|INSERM, ISPED, Centre INSERM U1219, F-33000 Bordeaux, France.
authors.forename: Melanie
authors.initials: M
authors.lastname: Le Goff
authors.affiliation: University Bordeaux, INCIA, UMR 5287, F-33000 Bordeaux, France.|CNRS, INCIA, UMR 5287, F-33000 Bordeaux, France.|EPHE, PSL Research University, F-33000 Bordeaux, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Chanraud
authors.affiliation: University Bordeaux, ISPED, Centre INSERM U1219, F-33000 Bordeaux, France.|INSERM, ISPED, Centre INSERM U1219, F-33000 Bordeaux, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dartigues
authors.affiliation: University Bordeaux, INCIA, UMR 5287, F-33000 Bordeaux, France.|CNRS, INCIA, UMR 5287, F-33000 Bordeaux, France.|EPHE, PSL Research University, F-33000 Bordeaux, France.|CHU de Bordeaux, F-33000 Bordeaux, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Allard
authors.affiliation: University Bordeaux, ISPED, Centre INSERM U1219, F-33000 Bordeaux, France.|INSERM, ISPED, Centre INSERM U1219, F-33000 Bordeaux, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Amieva
authors.affiliation: University Bordeaux, INCIA, UMR 5287, F-33000 Bordeaux, France.|CNRS, INCIA, UMR 5287, F-33000 Bordeaux, France.|EPHE, PSL Research University, F-33000 Bordeaux, France.
authors.forename: Gwénaëlle
authors.initials: GW
authors.lastname: Catheline
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology* / Q000523:psychology; D001284:Atrophy / Q000000981:diagnostic imaging / Q000473:pathology* / Q000523:psychology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D061212:Memory, Episodic; D009483:Neuropsychological Tests; D013060:Speech / Q000502:physiology*
keywords: episodic memory decline; grey matter atrophy; semantic fluency decline