title: Effectiveness of Early Invasive Therapy for Atrial Tachycardia in Adult Atrial-Baffle Survivors.
abstract: Adults who underwent complex atrial baffling as children via Mustard or Senning procedures are at heightened risk for atrial arrhythmias. Antiarrhythmic therapies are typically ineffective in this population. Accordingly, our team of pediatric and adult electrophysiologists investigated the effectiveness of early invasive transbaffle-access techniques to perform early radiofrequency ablation at the source of these clinically significant arrhythmias. For this retrospective study, we selected 11 adult survivors of atrial baffling (mean age, 34 ± 9 yr) who underwent clinically indicated electrophysiologic study after no more than one trial of antiarrhythmic therapy. Using transbaffle-access techniques and 3-dimensional mapping of the venous atria, we found 12 inducible arrhythmias in 10 patients: intra-atrial reentrant tachycardia (n=6), atrioventricular nodal reentrant tachycardia (n=3), focal atrial tachycardia (n=2), and repetitive double firing of the atrioventricular node (n=1). Defining success as short- and midterm freedom from arrhythmia, we analyzed outcomes of radiofrequency ablation at 1 and 6 months. At 1 month, ablation was 100% successful. At 6 months, after 11 ablations in 9 patients, 5 patients had no clinical recurrence, 2 had improved arrhythmia control from minimal medical therapy, and 2 were to undergo repeat study for recurrent tachycardia. In the recurrence-free patients, arrhythmias during electrophysiology study matched the types found clinically before the study. To our knowledge, this is the largest one-year cohort of adult survivors of atrial baffling to have undergone study by a combined pediatric-adult electrophysiology team. We conclude that early invasive transbaffle access for ablating diverse atrial tachyarrhythmias was effective in these patients.
authors.forename: Elisa A
authors.initials: EA
authors.lastname: Bradley
authors.forename: Ali N
authors.initials: AN
authors.lastname: Zaidi
authors.forename: Justin
authors.initials: J
authors.lastname: Morrison
authors.forename: Curt J
authors.initials: CJ
authors.lastname: Daniels
authors.forename: Steven
authors.initials: S
authors.lastname: Kalbfleisch
authors.forename: Naomi J
authors.initials: NJ
authors.lastname: Kertesz
mesh_terms: D000293:Adolescent; D000328:Adult; D000069278:Arterial Switch Operation / Q000009:adverse effects*; D017115:Catheter Ablation / Q000009:adverse effects; D061345:Early Medical Intervention / Q000379:methods*; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013617:Tachycardia, Supraventricular / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: Arrhythmias, cardiac/epidemiology/etiology; body surface potential mapping/methods; catheter ablation/methods; electrophysiologic techniques, cardiac; postoperative complications; recurrence; retrospective studies; tachycardia/etiology; transposition of great vessels/complications/physiopathology/surgery; treatment outcome