title: Effect of methomyl on sex steroid hormone and vitellogenin levels in serum of male tilapia (Oreochromis niloticus) and recovery pattern.
abstract: Tilapia were exposed to sub-lethal concentrations of 0, 0.2, 2, 20 or 200 μg/L for 30 days, then transferred to methomyl-free water for 18 days. E2, T, 11-KTand VTG in serum were examined. There were no significant changes in all the parameters in serum of tilapia exposed to 0.2 μg/L and 2 μg/L methomyl compared to the control. However, 20 μg/L and 200 μg/L have the potential to disrupt the endocrine system of male tilapia, as shown by its ability to increase VTG and E2and decrease T and 11-KT in serum. Thus it would appear the no observed adverse effect level for sexual steroid hormones of methomyl is lower than 2 μg/L. Recovery data showed that the effects produced by 20μg/L were reversible but not at 200μg/L. Furthermore, the sensitivity of above parameters to methomyl followed the order of VTG>E2>11-KT>T>GSI, suggesting VTG being the better biomarkers.
authors.affiliation: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors, Ministry of Agriculture, P. R. China; Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS, Wuxi, 214081, China.
authors.forename: Shun-Long
authors.initials: SL
authors.lastname: Meng
authors.affiliation: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors, Ministry of Agriculture, P. R. China; Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS, Wuxi, 214081, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Qiu
authors.affiliation: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors, Ministry of Agriculture, P. R. China; Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS, Wuxi, 214081, China.
authors.forename: Geng-Dong
authors.initials: GD
authors.lastname: Hu
authors.affiliation: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors, Ministry of Agriculture, P. R. China; Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS, Wuxi, 214081, China.
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Fan
authors.affiliation: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors, Ministry of Agriculture, P. R. China; Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS, Wuxi, 214081, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Song
authors.affiliation: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors, Ministry of Agriculture, P. R. China; Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS, Wuxi, 214081, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors, Ministry of Agriculture, P. R. China; Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS, Wuxi, 214081, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors, Ministry of Agriculture, P. R. China; Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS, Wuxi, 214081, China.
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Qu
authors.affiliation: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors, Ministry of Agriculture, P. R. China; Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS, Wuxi, 214081, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Li
authors.affiliation: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors, Ministry of Agriculture, P. R. China; Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS, Wuxi, 214081, China.
authors.forename: Jia-Zhang
authors.initials: JZ
authors.lastname: Chen
authors.affiliation: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Environmental Factors, Ministry of Agriculture, P. R. China; Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS, Wuxi, 214081, China.
authors.forename: Pao
authors.initials: P
authors.lastname: Xu
mesh_terms: D000818:Animals; D052244:Endocrine Disruptors / Q000633:toxicity*; D012739:Gonadal Steroid Hormones / Q000097:blood*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D008724:Methomyl / Q000633:toxicity*; D019055:No-Observed-Adverse-Effect Level; D017210:Tilapia / Q000378:metabolism*; D014819:Vitellogenins / Q000097:blood*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D052244:Endocrine Disruptors; D012739:Gonadal Steroid Hormones; D007306:Insecticides; D014819:Vitellogenins; D014874:Water Pollutants, Chemical; D008724:Methomyl
keywords: methomyl; recovery pattern; serum; sex steroid hormone; tilapia