title: LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson's Disease Patients with Wearing Off: A Prospective, Open-Label Study.
abstract: The efficacy of LSVT-BIG for advanced Parkinson's disease (PD) patients with wearing off remains to be determined. Therefore, we evaluated whether LSVT-BIG improves motor disability in eight PD patients with wearing off. Unified Parkinson's Disease Rating Scale (UPDRS) scores, daily off time, and mobility assessments were evaluated during the "on" time before and after the LSVT-BIG course. LSVT-BIG significantly improved UPDRS III scores at 4 weeks and UPDRS II scores in the "off" state at 12 weeks, with no changes in the other measures. The findings suggest that LSVT-BIG may be an effective therapy for advanced PD patients with wearing off.
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Tatsuya
authors.identifier: 0000-0002-6212-0265
authors.initials: T
authors.lastname: Ueno
authors.affiliation: Department of Rehabilitation, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Sasaki
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Haruo
authors.initials: H
authors.lastname: Nishijima
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Funamizu
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kon
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Haga
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Arai
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Chieko
authors.initials: C
authors.lastname: Suzuki
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Jin-Ichi
authors.initials: JI
authors.lastname: Nunomura
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Baba
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tomiyama