title: Novel screening for transthyretin amyloidosis by using fat ultrasonography.
abstract: We aimed to assess the possibility of using a noninvasive screening method for hereditary transthyretin amyloidosis by means of abdominal fat ultrasonography. Quantitative analysis of ultrasound B-mode images demonstrated a significant increase in mean echogenicity and a loss of the normal structure of the layers of fat tissue in patients with hereditary transthyretin amyloidosis (n = 19). The ultrasound features of the fat tissue and the degree of amyloid deposition seen histopathologically showed a significant correlation. These results suggest that abdominal fat ultrasonography may be a valuable method for screening for hereditary transthyretin amyloidosis. Ann Neurol 2017;81:604-608.
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Misumi
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto.
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Ueda
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto.
authors.forename: Taro
authors.initials: T
authors.lastname: Yamashita
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto.
authors.forename: Teruaki
authors.initials: T
authors.lastname: Masuda
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kinoshita
authors.affiliation: Department of Morphological and Physiological Sciences, Graduate School of Health Sciences, Kumamoto University, Kumamoto.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Tasaki
authors.affiliation: Department of Metabolism and Endocrinology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
authors.forename: Terumasa
authors.initials: T
authors.lastname: Nagase
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ando
mesh_terms: D000328:Adult; D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D028227:Amyloid Neuropathies, Familial / Q000000981:diagnostic imaging* / Q000378:metabolism; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050507:Subcutaneous Fat, Abdominal / Q000000981:diagnostic imaging* / Q000378:metabolism*; D014463:Ultrasonography / Q000379:methods* / Q000592:standards
chemical_list: D000682:Amyloid