title: Curcumin, A Potential Therapeutic Candidate for Anterior Segment Eye Diseases: A Review.
abstract: Curcumin, the major curcuminoid of the turmeric, has been extensively used in many countries since ancient time for preventing and/or treating a multitude of diseases. This review is to illustrate the researches on the properties of curcumin and its potential therapeutic efficacy in major anterior segment eye diseases. The bio-medical potential of curcumin is restricted because of its low solubility and digestive bioavailability. This review will discuss promising research in improving curcumin bioavailability through structural modification.In vitroandin vivoresearch made progress in studying the beneficial effects of curcumin on major anterior segment eye diseases, including anti-angiogenesis effect in corneal diseases; anti-inflammation or anti-allergy effects in dry eye disease, conjunctivitis, anterior uveitis; anti-proliferation and pro-apoptosis effects in pterygium; anti-oxidative stress, anti-osmotic stress, anti-lipid peroxidation, pro-apoptosis, regulating calcium homeostasis, sequestrating free radicals, protein modification and degradation effects in cataracts; neuroprotective effects in glaucoma. Curcumin exhibited to be a potent therapeutic candidate for treating those anterior segment eye diseases.
authors.affiliation: Department of Ophthalmology, The First Hospital of Jilin University Changchun, China.
authors.forename: Xiu-Fen
authors.initials: XF
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, The First Hospital of Jilin University Changchun, China.
authors.forename: Ji-Long
authors.initials: JL
authors.lastname: Hao
authors.affiliation: Department of Neurosurgery, The People's Hospital of Jilin Province Changchun, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Xie
authors.affiliation: Department of Ophthalmology, The First Hospital of Jilin University Changchun, China.
authors.forename: Nour Jama
authors.initials: NJ
authors.lastname: Mukhtar
authors.affiliation: Department of Molecular Pathology, Icahn School of Medicine at Mount Sinai, Manhattan NY, USA.
authors.forename: Wiley
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, The First Hospital of Jilin University Changchun, China.
authors.forename: Tayyab Hamid
authors.initials: TH
authors.lastname: Malik
authors.affiliation: Department of Ophthalmology, The First Hospital of Jilin University Changchun, China.
authors.forename: Cheng-Wei
authors.initials: CW
authors.lastname: Lu
authors.affiliation: Department of Radiology, The First Hospital of Jilin University Changchun, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Zhou
keywords: anterior uveitis; cataract; conjunctivitis; corneal diseases; curcumin; dry eye; glaucoma; pterygium