title: Therapeutic hypothermia increases the risk of cardiac arrhythmia for perinatal hypoxic ischaemic encephalopathy: A meta-analysis.
abstract: OBJECTIVE
  To determine whether therapeutic hypothermia after hypoxic ischaemic encephalopathy (HIE) in neonates increases the risk of cardiac arrhythmia during intervention.
  
  
  METHODS
  A meta-analysis was conducted using a fixed-effect model. Risk ratios, risk differences, and 95% confidence intervals, were measured.
  
  
  METHODS
  Studies identified from the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Google Scholar, previous reviews, and abstracts from onset to August, 2016.
  
  
  METHODS
  Reports that compared therapeutic hypothermia with normal care for neonates with HIE and that included data on safety or cardiac arrhythmia, which is of interest to patients and clinicians, were selected.
  
  
  RESULTS
  We found seven trials, encompassing 1322 infants that included information on safety or cardiac arrhythmia during intervention. Therapeutic hypothermia considerably increased the combined rate of cardiac arrhythmia in the seven trials (risk ratio 2.42, 95% confidence interval 1.23 to 4.76. p = 0.01; risk difference 0.02, 95% CI 0.01 to 0.04) during intervention.
  
  
  CONCLUSIONS
  In infants with hypoxic ischaemic encephalopathy, therapeutic hypothermia is associated with a consistent increase in cardiac arrhythmia during intervention.
authors.affiliation: Department of Critical Care Medicine, Sichuan University West China Medical Center, Chengdu, Sichuan, China.|Department of Critical Care Medicine, First People's Hospital of Zunyi in Guizhou Province, Third Clinical Hospital of Zunyi Medical College, Zunyi, Guizhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Critical Care Medicine, Sichuan University West China Medical Center, Chengdu, Sichuan, China.
authors.forename: Meizhu
authors.initials: M
authors.lastname: Lu
authors.affiliation: Department of Critical Care Medicine, Sichuan University West China Medical Center, Chengdu, Sichuan, China.
authors.forename: Chenlong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Critical Care Medicine, Sichuan University West China Medical Center, Chengdu, Sichuan, China.
authors.forename: Ruwen
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Critical Care Medicine, Sichuan University West China Medical Center, Chengdu, Sichuan, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Ou
authors.affiliation: Department of Critical Care Medicine, First People's Hospital of Zunyi in Guizhou Province, Third Clinical Hospital of Zunyi Medical College, Zunyi, Guizhou, China.
authors.forename: Jianju
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Neurology, People's Hospital of Yishui County, Yishui, Shandong, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Critical Care Medicine, Sichuan University West China Medical Center, Chengdu, Sichuan, China.
authors.forename: Yan
authors.identifier: http://orcid.org/0000-0002-9372-8134
authors.initials: Y
authors.lastname: Kang
mesh_terms: D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000628:therapy; D007223:Infant; D007231:Infant, Newborn; D016017:Odds Ratio; D016032:Randomized Controlled Trials as Topic; D012306:Risk