title: A Dimeric Bis(melamine)-Substituted Bispidine for Efficient Transmembrane H+/Cl-Cotransport.
abstract: A 3,7-diazabicyclo[3.3.1]nonane linking to two melamines is a unique transmembrane H+/Cl-carrier. In the solid state, the V-shaped compound forms a HCl-bound zig-zag network through cooperative protonation and hydrogen bond interactions. In the lipid membrane, the receptor forms a dimeric self-assembly involving multiple H+and Cl-leading to the efficient transport of the acid. The pH-dependent Cl-efflux observed for the compound was rationalized based on a gradual protonation model that confers an active transmembrane carrier at physiological pH.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Pune, Dr. Homi Bhabha Road, Pashan, Pune, 411008, Maharashtra, India.
authors.forename: Sopan Valiba
authors.initials: SV
authors.lastname: Shinde
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Pune, Dr. Homi Bhabha Road, Pashan, Pune, 411008, Maharashtra, India.
authors.forename: Pinaki
authors.identifier: 0000-0003-3951-4335
authors.initials: P
authors.lastname: Talukdar
keywords: cooperativity; ion transport; pH-dependent activity; protonation; symport mechanism