title: Antithymocyte globulin improves the survival of patients with myelodysplastic syndrome undergoing HLA-matched unrelated donor and haplo-identical donor transplants.
abstract: Significant advances have been achieved in the outcomes of patients with myelodysplastic syndromes (MDS) after both HLA-matched sibling donor transplants (MSDT) and non-MSDT, the latter including HLA-matched unrelated donor (MUDT) and haplo-identical donor transplants (HIDT). In this retrospective study, we analyzed the data of 85 consecutive patients with MDS who received allogeneic HSCT between Dec 2007 and Apr 2014 in our center. These patients comprised 38 (44.7%) who received MSDT, 29 (34.1%) MUDT, and 18 (21.2%) HIDT. The median overall survival (OS) was 60.2 months, the probabilities of OS being 63%, 57%, and 48%, at the first, second, and fifth year, respectively. Median OS post-transplant (OSPT) was 57.2 months, the probabilities of OSPT being 58%, 55%, and 48% at the first, second, and fifth year, respectively. The survival of patients receiving non-MSDT was superior to that of MSDT, median OSPT being 84.0 months and 23.6 months, respectively (P = 0.042); the findings for OS were similar (P = 0.028). We also found that using ATG in conditioning regimens significantly improved survival after non-MSDT, with better OS and OSPT (P = 0.016 and P = 0.025). These data suggest that using ATG in conditioning regimens may improve the survival of MDS patients after non-MSDT.
authors.affiliation: Jiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University; Institute of Blood and Marrow Transplantation; Collaborative Innovation of Haematology; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, 215000, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Jiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University; Institute of Blood and Marrow Transplantation; Collaborative Innovation of Haematology; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, 215000, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Jiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University; Institute of Blood and Marrow Transplantation; Collaborative Innovation of Haematology; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, 215000, China.
authors.forename: Jin-Yi
authors.initials: JY
authors.lastname: Zhou
authors.affiliation: Jiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University; Institute of Blood and Marrow Transplantation; Collaborative Innovation of Haematology; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, 215000, China.
authors.forename: Tong-Tong
authors.initials: TT
authors.lastname: Zhang
authors.affiliation: Jiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University; Institute of Blood and Marrow Transplantation; Collaborative Innovation of Haematology; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, 215000, China.
authors.forename: Song
authors.initials: S
authors.lastname: Jin
authors.affiliation: Jiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University; Institute of Blood and Marrow Transplantation; Collaborative Innovation of Haematology; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, 215000, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Jiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University; Institute of Blood and Marrow Transplantation; Collaborative Innovation of Haematology; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, 215000, China.
authors.forename: Su-Ning
authors.initials: SN
authors.lastname: Chen
authors.affiliation: Jiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University; Institute of Blood and Marrow Transplantation; Collaborative Innovation of Haematology; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, 215000, China.
authors.forename: Wei-Yang
authors.initials: WY
authors.lastname: Li
authors.affiliation: Jiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University; Institute of Blood and Marrow Transplantation; Collaborative Innovation of Haematology; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, 215000, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Jiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University; Institute of Blood and Marrow Transplantation; Collaborative Innovation of Haematology; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, 215000, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Miao
authors.affiliation: Jiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University; Institute of Blood and Marrow Transplantation; Collaborative Innovation of Haematology; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, 215000, China.
authors.forename: De-Pei
authors.initials: DP
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D019653:Myeloablative Agonists / Q000627:therapeutic use*; D009190:Myelodysplastic Syndromes / Q000276:immunology / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D035781:Siblings; D016019:Survival Analysis; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D061349:Unrelated Donors
chemical_list: D000961:Antilymphocyte Serum; D006680:HLA Antigens; D019653:Myeloablative Agonists