title: Mycosis Fungoides: Experience in a Pediatric Hospital.
abstract: Mycosis fungoides (MF), the most common primary cutaneous T-cell lymphoma, is unusual in children.
  
  
  OBJECTIVE
  We aimed to describe the epidemiologic, clinical, histopathologic, and immunophenotypic characteristics of MF as well as treatments and course of disease in a pediatric case series.
  
  
  METHODS
  Data for all patients admitted to our pediatric hospital (Hospital Dr. J. P. Garrahan) in Argentina with a clinical and histopathologic diagnosis of MF between August 1988 and July 2014 were included.
  
  
  RESULTS
  A total of 14 patients were diagnosed with MF. The ratio of boys to girls was 1:1.33. The mean age at diagnosis was 11.23 years (range, 8-15 years). The mean time between onset and diagnosis was 3.5 years (range, 4 months-7 years). All patients had hypopigmented MF and 42% also presented the features of classic MF. Seven (50%) had the CD8+immunophenotype exclusively. Seventy-eight percent were in stage IB at presentation. Phototherapy was the treatment of choice. Four patients relapsed at least once and skin lesions progressed in 3 patients. All patients improved.
  
  
  CONCLUSIONS
  MF is unusual in children. The hypopigmented form is the most common. Diagnosis is delayed because the condition is similar to other hypopigmented diseases seen more often in childhood. Although prognosis is good, the rate of recurrence is high, so long-term follow-up is necessary.
authors.affiliation: Servicio de Dermatología, Hospital de Pediatría Dr. Garrahan, Buenos Aires, Argentina.
authors.forename: A B
authors.initials: AB
authors.lastname: Cervini
authors.affiliation: Servicio de Dermatología, Hospital de Pediatría Dr. Garrahan, Buenos Aires, Argentina. Electronic address: torresnat@yahoo.com.ar.
authors.forename: A N
authors.initials: AN
authors.lastname: Torres-Huamani
authors.affiliation: Servicio de Hemato-Oncología, Hospital de Pediatría Dr. Garrahan, Buenos Aires, Argentina.
authors.forename: C
authors.initials: C
authors.lastname: Sanchez-La-Rosa
authors.affiliation: Servicio de Anatomía Patológica, Hospital de Pediatría Dr. Garrahan, Buenos Aires, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: Galluzzo
authors.affiliation: Servicio de Anatomía Patológica, Hospital de Pediatría Dr. Garrahan, Buenos Aires, Argentina.
authors.forename: V
authors.initials: V
authors.lastname: Solernou
authors.affiliation: Servicio de Biología Molecular, Hospital de Pediatría Dr. Garrahan, Buenos Aires, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Digiorge
authors.affiliation: Servicio de Biología Molecular, Hospital de Pediatría Dr. Garrahan, Buenos Aires, Argentina.
authors.forename: P
authors.initials: P
authors.lastname: Rubio
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D017668:Age of Onset; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001118:Argentina / Q000453:epidemiology; D002648:Child; D003430:Cross-Sectional Studies; D057210:Delayed Diagnosis; D003951:Diagnostic Errors; D005260:Female; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology; D008297:Male; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology / Q000532:radiotherapy; D011701:PUVA Therapy; D012008:Recurrence; D012189:Retrospective Studies; D012871:Skin Diseases / Q000175:diagnosis; D012878:Skin Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology / Q000532:radiotherapy; D014467:Ultraviolet Therapy
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Children; Linfoma cutáneo primario; Lymphoma: Primary cutaneous; Micosis fungoide; Mycosis fungoides; Niños