title: Combined Signature of the Fecal Microbiome and Metabolome in Patients with Gout.
abstract: This study employed microbiome and metabolome analysis to explore the fecal signatures of gout patients. Fecal samples from 52 male individuals (26 healthy controls and 26 gout patients) were analyzed by1H NMR spectroscopy and Illumina Miseq sequencing. The signatures of microbiome showed being up-regulation of opportunistic pathogens, such asBacteroides, Porphyromonadaceae Rhodococcus,ErysipelatoclostridiumandAnaerolineaceae. The signatures of metabolome were some altered metabolites which may involve uric acid excretion, purine metabolism, and inflammatory responses. Meanwhile, the correlation between discrepant metabolites and microbial taxa indicated that they could be the combined signatures of gout. This study suggests that the combined analysis of the fecal microbiome and metabolome may effectively characterize diseases.
authors.affiliation: College of Basic Medical Science, Zhejiang Chinese Medical University Hangzhou, China.
authors.forename: Tiejuan
authors.initials: T
authors.lastname: Shao
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shao
authors.affiliation: College of Basic Medical Science, Zhejiang Chinese Medical University Hangzhou, China.
authors.forename: Haichang
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Basic Medical Science, Zhejiang Chinese Medical University Hangzhou, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Xie
authors.affiliation: College of Basic Medical Science, Zhejiang Chinese Medical University Hangzhou, China.
authors.forename: Zhixing
authors.initials: Z
authors.lastname: He
authors.affiliation: College of Basic Medical Science, Zhejiang Chinese Medical University Hangzhou, China.
authors.forename: Chengping
authors.initials: C
authors.lastname: Wen
keywords: fecal; gout; metabolome; microbiome; signature