title: Antiemetic and Myeloprotective Effects ofRhus verniciflua Stokein a Cisplatin-Induced Rat Model.
abstract: Rhus vernicifluaStoke has been commonly used in traditional medicine to treat gastrointestinal (GI) dysfunction diseases. In order to investigate pharmacological properties ofRhus vernicifluaStoke water extract (RVX) on cisplatin-induced amnesia, RVX (0, 25, 50, or 100 mg/kg) was orally administrated for five consecutive days after a single intraperitoneal injection of cisplatin (6 mg/kg) to SD rat. Cisplatin injection significantly increased the kaolin intake (emesis) but reduced the normal diet intake (anorexia) whereas the RVX treatment significantly improved these abnormal diet behaviors at both the acute and delayed phase. The serotonin concentration and the related gene expressions (5-HT3 receptors and SERT) in small intestine tissue were abnormally altered by cisplatin injection, which were significantly attenuated by the RVX treatment. Histological findings of gastrointestinal tracts, as well as the proteins level of proinflammatory cytokines (TNF-α, IL-6, and IL-1β), revealed the beneficial effect of RVX on cisplatin-induced gastrointestinal inflammation. In addition, RVX significantly improved cisplatin-induced myelosuppression, as evidenced by the observation of leukopenia and by histological examinations in bone marrow. Our findings collectively indicatedRhus vernicifluaStoke improved the resistance of rats to chemotherapy-related adverse effects in the gastrointestinal track and bone marrow.
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 176-9 Daeheung-ro, Jung-gu, Daejeon 34929, Republic of Korea.
authors.forename: Hyo-Seon
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 176-9 Daeheung-ro, Jung-gu, Daejeon 34929, Republic of Korea.
authors.forename: Hyeong-Geug
authors.initials: HG
authors.lastname: Kim
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 176-9 Daeheung-ro, Jung-gu, Daejeon 34929, Republic of Korea.
authors.forename: Hwi-Jin
authors.initials: HJ
authors.lastname: Im
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 176-9 Daeheung-ro, Jung-gu, Daejeon 34929, Republic of Korea.
authors.forename: Jin-Seok
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 176-9 Daeheung-ro, Jung-gu, Daejeon 34929, Republic of Korea.
authors.forename: Sung-Bae
authors.initials: SB
authors.lastname: Lee
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 176-9 Daeheung-ro, Jung-gu, Daejeon 34929, Republic of Korea.
authors.forename: Won-Yong
authors.initials: WY
authors.lastname: Kim
authors.affiliation: TKM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Daejeon 34052, Republic of Korea.
authors.forename: Hye-Won
authors.initials: HW
authors.lastname: Lee
authors.affiliation: Department of Applied Chemistry, Daejeon University, 62 Daehak-ro, Dong-gu, Daejeon 34520, Republic of Korea.
authors.forename: Sam-Keun
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Department of Applied Chemistry, Daejeon University, 62 Daehak-ro, Dong-gu, Daejeon 34520, Republic of Korea.
authors.forename: Chang Kyu
authors.initials: CK
authors.lastname: Byun
authors.affiliation: Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 176-9 Daeheung-ro, Jung-gu, Daejeon 34929, Republic of Korea.
authors.forename: Chang-Gue
authors.identifier: 0000-0002-6963-5229
authors.initials: CG
authors.lastname: Son