title: Immunomodulatory effects of coated gold nanoparticles in LPS-stimulatedin vitroandin vivomurine model systems.
abstract: The ability of nanoparticle surface functionalities to regulate immune responses during an immunological challenge (i. e. inflammation) would open new doors for their use in non-prophylactic therapeutics. We report here the use of functionalized 2 nm core gold nanoparticles to control the immunological responses ofin vitroandin vivosystems presented with an inflammatory challenge. The results showed that NPs bearing a hydrophobic zwitterionic functionality boost inflammatory outcomes while hydrophilic zwitterionic NPs generate minimal immunological responses. Surprisingly, tetra(ethylene glycol) headgroups generate a significant anti-inflammatory response bothin vitroandin vivo. These results demonstrate the ability of simple surface ligands to provide immunomodulatory properties, making them promising leads for the therapeutic usage of nanomaterials in diseases involving inflammation.
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, 01003, USA.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Moyano
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, 01003, USA.
authors.forename: Yuanchang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Veterinary and Animals Sciences, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, 01003, USA.
authors.forename: Furkan
authors.initials: F
authors.lastname: Ayaz
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, 01003, USA.
authors.forename: Singyuk
authors.initials: S
authors.lastname: Hou
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, 01003, USA.
authors.forename: Premsak
authors.initials: P
authors.lastname: Puangploy
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, 01003, USA.
authors.forename: Bradley
authors.initials: B
authors.lastname: Duncan
authors.affiliation: Department of Veterinary and Animals Sciences, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, 01003, USA.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Osborne
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, 01003, USA.
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
keywords: Inflammation; gold nanoparticles; prophylactic; zwitterions