title: BDNF controls object recognition memory reconsolidation.
abstract: Reconsolidation restabilizes memory after reactivation. Previously, we reported that the hippocampus is engaged in object recognition memory reconsolidation to allow incorporation of new information into the original engram. Here we show that BDNF is sufficient for this process, and that blockade of BDNF function in dorsal CA1impairs updating of the reactivated recognition memory trace.
authors.affiliation: Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, RN 59056-450 Natal, Brazil.
authors.forename: Andressa
authors.initials: A
authors.lastname: Radiske
authors.affiliation: Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, RN 59056-450 Natal, Brazil.
authors.forename: Janine I
authors.initials: JI
authors.lastname: Rossato
authors.affiliation: Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, RN 59056-450 Natal, Brazil.
authors.forename: Maria Carolina
authors.initials: MC
authors.lastname: Gonzalez
authors.affiliation: Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, RN 59056-450 Natal, Brazil.
authors.forename: Cristiano A
authors.initials: CA
authors.lastname: Köhler
authors.affiliation: Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, RN 59056-450 Natal, Brazil.
authors.forename: Lia R
authors.initials: LR
authors.lastname: Bevilaqua
authors.affiliation: Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, RN 59056-450 Natal, Brazil. Electronic address: martin.cammarota@neuro.ufrn.br.
authors.forename: Martín
authors.initials: M
authors.lastname: Cammarota
mesh_terms: D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D000906:Antibodies / Q000494:pharmacology*; D019208:Brain-Derived Neurotrophic Factor / Q000276:immunology / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D000069077:Memory Consolidation / Q000187:drug effects / Q000502:physiology*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology*
chemical_list: D000906:Antibodies; D019208:Brain-Derived Neurotrophic Factor; D011500:Protein Synthesis Inhibitors; D000841:Anisomycin
keywords: Anisomycin; Muscimol; Novelty; Retrieval; α-amanitin