title: Encapsulation of aggregated gold nanoclusters in a metal-organic framework for real-time monitoring of drug release.
abstract: Gold nanoclusters (AuNCs), which have stable luminescence and negligible biotoxicity, are a promising candidate in biological fields. However, their low photoluminescence (PL) efficiency is unsatisfactory. Herein, aggregated gold nanoclusters (aAuNCs) were confined in a metal-organic framework (MOF) to maintain their aggregation, restrict the rotation of their ligands, and further improve their quantum yield (QY) to 7.74%. The aAuNCs-MOF exhibited high luminescence and good biocompatibility. More importantly, in addition to its pH-dependent luminescence and external porosity, the complex was applied for the first time in real-time monitoring of drug release.
authors.affiliation: State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of Science and Technology of China, Hefei, Anhui 230029, P. R. China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Cao
authors.affiliation: State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of the Chinese Academy of Sciences, Beijing 100039, P. R. China.
authors.forename: Enguo
authors.initials: E
authors.lastname: Ju
authors.affiliation: State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of the Chinese Academy of Sciences, Beijing 100039, P. R. China.
authors.forename: Chaoqun
authors.initials: C
authors.lastname: Liu
authors.affiliation: State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of the Chinese Academy of Sciences, Beijing 100039, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of the Chinese Academy of Sciences, Beijing 100039, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Dong
authors.affiliation: State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Jinsong
authors.identifier: http://orcid.org/0000-0002-7506-627X
authors.initials: J
authors.lastname: Ren
authors.affiliation: State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.
authors.forename: Xiaogang
authors.identifier: http://orcid.org/0000-0003-2868-3205
authors.initials: X
authors.lastname: Qu
mesh_terms: D065546:Drug Liberation; D006046:Gold; D006367:HeLa Cells; D006801:Humans; D049449:Luminescence; D053768:Metal Nanoparticles; D000073396:Metal-Organic Frameworks
chemical_list: D000073396:Metal-Organic Frameworks; D006046:Gold