title: T(ell)TALE signs of aging.
abstract: Transcriptional activator-like effectors (TALEs) have emerged as powerful tools for genome editing. A recent study published by Cell Research reports that fusion of thioredoxin to TALEs unlocks their full potential in live-cell imaging to accurately analyze genome instability, telomere attrition and epigenetic alterations that are hallmarks of aging.
authors.affiliation: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.
authors.forename: Reshma
authors.initials: R
authors.lastname: Taneja
authors.affiliation: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.|Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.|Buck Institute for Research on Aging, Novato, CA 94945, USA.
authors.forename: Brian K
authors.initials: BK
authors.lastname: Kennedy
mesh_terms: D002843:Chromatin; D000072669:Gene Editing; D005818:Genetic Engineering; D016615:Telomere; D000071336:Transcription Activator-Like Effectors
chemical_list: D002843:Chromatin; D000071336:Transcription Activator-Like Effectors