title: Aquaporins in Urinary System.
abstract: Several aquaporin (AQP )-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 -6 in the collecting duct; AQP7 in the proximal tubule; AQP8 in the proximal tubule and collecting duct; and AQP11 in the endoplasmic reticulum of proximal tubule cells. AQP2 is the vasopressin-regulated water channel that is important in hereditary and acquired diseases affecting urine-concentrating ability. The roles of AQPs in renal physiology and transepithelial water transport have been determined using AQP knockout mouse models. This chapter describes renal physiologic insights revealed by phenotypic analysis of AQP knockout mice and the prospects for further basic and clinical studies.
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
authors.forename: Weiling
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China. baoxue@bjmu.edu.cn.|State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China. baoxue@bjmu.edu.cn.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing, 100191, China. baoxue@bjmu.edu.cn.
authors.forename: Baoxue
authors.initials: B
authors.lastname: Yang
mesh_terms: D000818:Animals; D051398:Aquaporin 1 / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D005786:Gene Expression Regulation; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000378:metabolism*; D007671:Kidney Concentrating Ability / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009994:Osmolar Concentration; D011141:Polyuria / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D014508:Urea / Q000378:metabolism*; D014867:Water / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: C496020:AQP1 protein, human; D020033:Protein Isoforms; D014867:Water; D051398:Aquaporin 1; D014508:Urea
keywords: Knockout mouse; NDI; Polyuria; Urine concentrating mechanism; Water