title: Is lower uterine segment involvement a prognostic factor in endometrial cancer?
abstract: The purpose of this study is to investigate the prognostic significance of lower uterine segment (LUS) involvement in endometrial cancer (EC).
  
  
  
  We reviewed the patients who were operated at our institution between July 2007 and March 2015 with the diagnosis of EC. Tumors localized in the corpus and involving the LUS or localized entirely in the LUS formed Group A, while tumors in the uterine corpus without LUS involvement formed Group B. Clinicopathological characteristics and survival of the patients were compared in both groups.
  
  
  
  A total of 500 patients were included in the study. There were 139 patients who had tumors involving the LUS and formed Group A, while 361 patients with endometrial tumors in the uterine corpus without LUS involvement formed Group B. We did not detect a significant difference between survival of the patients in group A and group B (78 months vs. 87 months, respectively; P > 0.05).
  
  
  
  We found that LUS involvement was not an independent prognostic factor for poor survival, but it is associated with other poor prognostic factors such as deep myometrial invasion, uterine serosal involvement, lymphovascular space invasion, lymph node metastasis and higher FIGO grade.
authors.affiliation: Department of Gynecology and Obstetrics, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Erkaya
authors.affiliation: Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Öz
authors.affiliation: Department of Gynecology and Obstetrics, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Hasan Onur
authors.initials: HO
authors.lastname: Topçu
authors.affiliation: Department of Pathology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Ali Levent
authors.initials: AL
authors.lastname: Şirvan
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Hitit University, Çorum, Turkey.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Güngör
authors.affiliation: Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet Mutlu
authors.initials: MM
authors.lastname: Meydanli
mesh_terms: D000368:Aged; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000473:pathology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D014599:Uterus / Q000473:pathology*