title: In situ development and application of natural coatings on non-absorbable sutures to reduce incision site infections.
abstract: OBJECTIVE
  The purpose of the study was the development of a suture line that has antibacterial properties and reduces the chance of wound infection thus facilitating the healing process.
  
  
  METHODS
  Hydrolysed chitosan, turmeric powder and clove oil were used in different proportions to formulate antimicrobial coating for the polyethylene terephthalate (PET) and polyamide (Nylon 6) threads. The threads were coated using a lab-scale yarn sizing machine. Tensile, and knot strength of the coated sutures were measured. As was the antimicrobial action of Staphylococcus aureus strain ATCC29213.
  
  
  RESULTS
  The results show that coatings have slightly improved the tensile and knot strength properties of these sutures. The coated sutures also have satisfactory microbial inhibition against Staphylococcus aureus.
  
  
  CONCLUSIONS
  The coating slightly improved the tensile strength of the sutures. However, the knot is the weakest part of the suture strand. All the formulations of the coating have shown satisfactory antimicrobial activity against Gram-positive Staphylococcus aureus bacteria. We conclude that application of natural coatings on non-absorbable sutures can be useful to reduce the incisions and wound site infections.
authors.affiliation: Director, Research and Development Division, National Textile University, Faisalabad, Punjab, Pakistan.
authors.forename: R
authors.initials: R
authors.lastname: Masood
authors.affiliation: Dean, Faculty of Engineering and Technology, National Textile University, Faisalabad, Punjab, Pakistan.
authors.forename: T
authors.initials: T
authors.lastname: Hussain
authors.affiliation: Research Assistant, Research and Development Division, National Textile University, Faisalabad, Punjab, Pakistan.
authors.forename: M
authors.initials: M
authors.lastname: Umar
authors.affiliation: Research Assistant, Research and Development Division, National Textile University, Faisalabad, Punjab, Pakistan.
authors.lastname: Azeemullah
authors.affiliation: Research Assistant, Research and Development Division, National Textile University, Faisalabad, Punjab, Pakistan.
authors.forename: T
authors.initials: T
authors.lastname: Areeb
authors.affiliation: Research Assistant, Research and Development Division, National Textile University, Faisalabad, Punjab, Pakistan.
authors.forename: S
authors.initials: S
authors.lastname: Riaz
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D048271:Chitosan; D020099:Coated Materials, Biocompatible; D030024:Curcuma; D006801:Humans; D006868:Hydrolysis; D009822:Oils, Volatile; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013537:Sutures; D014945:Wound Healing
chemical_list: D000891:Anti-Infective Agents, Local; D020099:Coated Materials, Biocompatible; D009822:Oils, Volatile; D048271:Chitosan
keywords: antimicrobial action; surgical site infection; sutures; wound closure; wound site infection