title: [The effect of the level of total sodium deposited in the myocardium on its stiffness].
abstract: OBJECTIVE
  To determine a relationship between the level of total sodium in the myocardium to its stiffness.
  
  
  METHODS
  The investigation enrolled 18 hypertensive patients who had suddenly died; their mean age was 40±10 years; mean waist circumference, 102±12.5 cm; height, 170±7.7 cm; myocardial mass, 319±53 g.
  
  
  RESULTS
  The variation in the myocardial level of total sodium averaged 211.7±37.5 (min, 71.5; max, 226.17) mmol/l. The sodium level was ascertained to be affected to the greatest extent by myocardial mass (SS=3615.56; p=0.00029) and age at death (SS=1965.568; p=0.0029), whereas gender and smoking had a considerably lower impact (SS=778.584; p=0.03). A univariate regression analysis showed that there was a relationship between myocardial sodium levels and the thickness of the anterior wall of the left ventricle (β=0.94; p=0.000001; r2=0.88), that of the anterior wall of the right ventricle (β=0.82; p=0.000021; r2=0.66), and that of the interventricular septum (β=0.94; p=0.000001; r2=0.89). The wall thickness of the myocardium was established to depend on its sodium level (SS=21813.89; p=0.000001; r2=0.88): the higher sodium amount in the myocardium, the thicker its walls. The average velocity of acoustic wave propagation was 6.24±0.51 m/sec. A significant correlation was observed between sodium concentrations in the myocardium and its stiffness (β=0.72; p=0.00062; r2=0.49).
  
  
  CONCLUSIONS
  The level of sodium deposited in the myocardium, which is directly related to dietary sodium intake, is significantly correlated with myocardial stiffness. It can be assumed that the elevated level of sodium deposited in the myocardium is an independent factor that changes the stiffness of the myocardium and appears to influence the development of its diastolic dysfunction.
authors.affiliation: N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: G P
authors.initials: GP
authors.lastname: Arutyunov
authors.affiliation: N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: D O
authors.initials: DO
authors.lastname: Dragunov
authors.affiliation: N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: G P
authors.initials: GP
authors.lastname: Arutyunov
authors.affiliation: N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Sokolova
authors.affiliation: Forensic Medical Expert Examination Bureau, Moscow Healthcare Department, Moscow, Russia.
authors.forename: I P
authors.initials: IP
authors.lastname: Papyshev
authors.affiliation: Forensic Medical Expert Examination Bureau, Moscow Healthcare Department, Moscow, Russia.
authors.forename: E M
authors.initials: EM
authors.lastname: Kildyushov
authors.affiliation: N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Negrebetsky
authors.affiliation: N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Fedorova
mesh_terms: D000328:Adult; D001344:Autopsy; D004548:Elasticity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology*; D012964:Sodium / Q000378:metabolism*
chemical_list: D012964:Sodium