title: Clinical Evaluation of High and Low-Level Laser Treatment (CO2vsInGaAlP Diode Laser) for Recurrent Aphthous Stomatitis.
abstract: BACKGROUND
  Recurrent aphthous stomatitis (RAS) is one of the most common lesions in the oral cavity. Due to its multifactorial nature, there is no definitive treatment for RAS. Laser therapy is one of the suggested treatments to reduce patient's discomfort.
  
  
  OBJECTIVE
  The purpose of the present clinical trial is to assess the effect of low and high level laser therapy on pain control and wound healing of RAS.
  
  
  METHODS
  Thirty six patients with minor RAS were divided into three groups. Group 1 (n=14) received CO2 laser, group 2 (n=12) were treated with InGaAlP Diode laser and group 3 (n=10) received sham laser as placebo. All patients were evaluated daily up to 15 days after receiving one session of laser therapy. Pain severity before and after treatment, wound healing, patient's satisfaction, and functional disturbance before and after treatment were recorded for each patient.
  
  
  RESULTS
  According to statistical analysis, pain reduction after treatment in group 1 was 7.00±2.41, in group 2 was 2.08±2.31, and in group 3 was 1.40±1.77. In addition, a significant difference was observed in the reduction of functional complications in CO2laser treated patients compared to the other two groups.
  
  
  CONCLUSIONS
  High-level laser treatment showed analgesic effects on RAS, but no healing was observed. Low-level laser therapy demonstrated no positive effect on recurrent aphthous ulcers.
authors.affiliation: Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Nasim
authors.initials: N
authors.lastname: Zeini Jahromi
authors.affiliation: Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Janan
authors.initials: J
authors.lastname: Ghapanchi
authors.affiliation: Dept. of Oral and Maxillofacial Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Pourshahidi
authors.affiliation: Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Zahed
authors.affiliation: Dept. of Oral Medicine, Dental School, Azad University, Tehran, Iran.
authors.forename: Hooman
authors.initials: H
authors.lastname: Ebrahimi
keywords:  Laser therapy ;  Stomatitis ;  Wound healing; Aphthous 