title: Support for the association between RORA gene polymorphisms and the DSM-5 posttraumatic stress disorder symptoms in male earthquake survivors in China.
abstract: BACKGROUND
  This study examined the association between interaction of retinoid-related orphan receptor alpha (RORA) (rs8042149) genotype x trauma exposure and post-traumatic stress disorder (PTSD) symptoms.
  
  
  METHODS
  A total of 1196 Chinese adults who suffered from a deadly 2008 Wenchuan earthquake participated in this study. PTSD symptoms were measured with the PTSD Checklist for DSM-5 (PCL-5). A custom-by-design 2×48-Plex SNPscan™Kit were used to genotype the RORA rs8042149 SNP.
  
  
  RESULTS
  Our results showed that the interaction of rs8042149 genotype x trauma exposure was associated with total PTSD symptoms in males. Moreover, the rs8042149 genotype x trauma exposure interaction was only associated with severity of the negative affect, anhedonia and dysphoric arousal symptoms in males.
  
  
  CONCLUSIONS
  A moderate sample exposed to a specific event was assessed with a self-reported PTSD measure.
  
  
  CONCLUSIONS
  This study provides preliminary evidence supporting the functional role of RORA in PTSD, and adds to the knowledge for understanding the genetic underpinnings of PTSD. Moreover, this study carries implications for understanding the comorbidity of PTSD and the sex-specific expression of PTSD's symptoms.
authors.affiliation: Laboratory for Traumatic Stress studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Chengqi
authors.initials: C
authors.lastname: Cao
authors.affiliation: Laboratory for Traumatic Stress studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address: wangli1@psych.ac.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Laboratory for Traumatic Stress studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Cao
authors.affiliation: Department of Biostatistics, Peking University Clinical Research Institute, China.
authors.forename: Chongya
authors.initials: C
authors.lastname: Dong
authors.affiliation: People's Hospital of Deyang City, Deyang, Sichuan, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: People's Hospital of Deyang City, Deyang, Sichuan, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Luo
authors.affiliation: Division of Medical Psychology, Chinese Peoples' Liberation Army General Hospital & Medical School, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Cui
authors.affiliation: Division of Medical Psychology, Chinese Peoples' Liberation Army General Hospital & Medical School, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Laboratory for Traumatic Stress studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004190:Disasters; D055866:Earthquakes; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D008297:Male; D008875:Middle Aged; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*; D017741:Survivors / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; C539738:RORA protein, human
keywords: Association study; Gene–environment interaction; PTSD; RORA; Single-nucleotide polymorphism