title: Local entrainment of oscillatory activity induced by direct brain stimulation in humans.
abstract: In a quest for direct evidence of oscillation entrainment, we analyzed intracerebral electroencephalographic recordings obtained during intracranial electrical stimulation in a cohort of three medication-resistant epilepsy patients tested pre-surgically. Spectral analyses of non-epileptogenic cerebral sites stimulated directly with high frequency electrical bursts yielded episodic local enhancements of frequency-specific rhythmic activity, phase-locked to each individual pulse. These outcomes reveal an entrainment of physiological oscillatory activity within a frequency band dictated by the rhythm of the stimulation source. Our results support future uses of rhythmic stimulation to elucidate the causal contributions of synchrony to specific aspects of human cognition and to further develop the therapeutic manipulation of dysfunctional rhythmic activity subtending the symptoms of some neuropsychiatric conditions.
authors.affiliation: CNRS UMR 7225, Institut du Cerveau et de la Moelle Epinière, Cerebral Dynamics, Plasticity and Rehabilitaion Group, Frontlab, Paris, France.
authors.forename: Julià L
authors.initials: JL
authors.lastname: Amengual
authors.affiliation: CNRS UMR 7225, Institut du Cerveau et de la Moelle Epinière, Cerebral Dynamics, Plasticity and Rehabilitaion Group, Frontlab, Paris, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Vernet
authors.affiliation: Epilepsy Unit, Dept. of Neurology, Pitié-Salpêtrière Hospital, APHP, Paris, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Adam
authors.affiliation: CNRS UMR 7225, Institut du Cerveau et de la Moelle Epinière, Cerebral Dynamics, Plasticity and Rehabilitaion Group, Frontlab, Paris, France.|Department of Anatomy and Neurobiology, Laboratory of Cerebral Dynamics, Boston University School of Medicine, Boston, MA, USA.|Cognitive Neuroscience and Information Technology Research Program, Open University of Catalonia (UOC), Barcelona, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Valero-Cabré
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology; D003071:Cognition; D046690:Deep Brain Stimulation / Q000379:methods*; D000069279:Drug Resistant Epilepsy / Q000503:physiopathology* / Q000628:therapy; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male