title: MicroRNAs as Peripheral Biomarkers in Aging and Age-Related Diseases.
abstract: MicroRNAs (miRNAs) are found in the circulatory biofluids considering the important molecules for biomarker study in aging and age-related diseases. Blood or blood components (serum/plasma) are primary sources of circulatory miRNAs and can release these in cell-free form either bound with some protein components or encapsulated with microvesicle particles, called exosomes. miRNAs are quite stable in the peripheral circulation and can be detected by high-throughput techniques like qRT-PCR, microarray, and sequencing. Intracellular miRNAs could modulate mRNA activity through target-specific binding and play a crucial role in intercellular communications. At a pathological level, changes in cellular homeostasis lead to the modulation of molecular function of cells; as a result, miRNA expression is deregulated. Deregulated miRNAs came out from cells and frequently circulate in extracellular body fluids as part of various human diseases. Most common aging-associated diseases are cardiovascular disease, cancer, arthritis, dementia, cataract, osteoporosis, diabetes, hypertension, and neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Variation in the miRNA signature in a diseased peripheral circulatory system opens up a new avenue in the field of biomarker discovery. Here, we measure the biomarker potential of circulatory miRNAs in aging and various aging-related pathologies. However, further more confirmatory researches are needed to elaborate these findings at the translation level.
authors.affiliation: Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, United States. Electronic address: subodh.kumar@ttuhsc.edu.
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, United States.
authors.forename: M
authors.initials: M
authors.lastname: Vijayan
authors.affiliation: Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, United States; Department of Biotechnology, Sri Guru Gobind Singh College, Chandigarh, India.
authors.forename: J S
authors.initials: JS
authors.lastname: Bhatti
authors.affiliation: Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, United States; Texas Tech University Health Sciences Center, Lubbock, TX, United States.
authors.forename: P H
authors.initials: PH
authors.lastname: Reddy
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D004194:Disease; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Age-related diseases; Aging; Alzheimer's disease; Biomarker; Circulatory microRNA