title: Positive association between short-term ambient air pollution exposure and children blood pressure in China-Result from the Seven Northeast Cities (SNEC) study.
abstract: The impact of ambient air pollution on health causes concerns in China. However, little is known about the association of short-term air pollution exposure with blood pressure (BP) in children. The goal of present study was to assess the association between short-term air pollution and BP in children from a highly polluted area in China. This study enrolled 9354 children in 24 elementary and middle schools (aged 5-17 years) from the Seven Northeast Cities (SNEC) study, respectively, during the period of 2012-2013. Ambient air pollutants, including particulate matter with an aerodynamic diameter of ≤10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2) and ozone (O3) on the days (1-5 days) preceding BP examination were collected from local air monitoring stations. Generalized additive models and two-level regression analyses were used to evaluate the relationship between air pollution and BP after adjusting for other covariates. Results showed that with an interquartile range (IQR) increase in PM10(50.0 μg/m3) and O3(53.0 μg/m3) level during the 5-day mean exposure, positive associations with elevated BP were observed, with an odds ratio of 2.17 (95% CI, 1.61-2.93) for PM10and 2.77 (95% CI, 1.94-3.95) for O3. Both systolic BP and diastolic BP levels were positively associated with an IQR increase of four air pollutants at different lag times. Specifically, an IQR increase in the 5-day mean of PM10and O3was associated with elevation of 2.07 mmHg (95% CI, 1.71-2.44) and 3.29 mmHg (95% CI, 2.86-3.72) in systolic BP, respectively. When stratified by sex, positive relationships were observed for elevated BP with NO2exposure only in males. This is the first report on the relationship between ambient short-term air pollution exposure and children BP in China. Findings indicate a need to control air pollutants and protect children from heavy air pollution exposure in China.
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Zeng
authors.affiliation: Department of Epidemiology, College for Public Health and Social Justice, Saint Louis University, Saint Louis 63104, USA.
authors.forename: Zhengmin Min
authors.initials: ZM
authors.lastname: Qian
authors.affiliation: School of Social Work, College for Public Health and Social Justice, Saint Louis University, Saint Louis 63104, USA.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Vaughn
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Indiana University Bloomington, Bloomington, IN 47405, USA.
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Nelson
authors.affiliation: Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Vic 3052, Australia.
authors.forename: Shyamali C
authors.initials: SC
authors.lastname: Dharmage
authors.affiliation: Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Vic 3052, Australia.
authors.forename: Gayan
authors.initials: G
authors.lastname: Bowatte
authors.affiliation: Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Vic 3052, Australia.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Perret
authors.affiliation: Guangdong Environmental Monitoring Center, State Environmental Protection Key Laboratory of Regional Air Quality Monitoring, Guangdong Environmental Protection Key Laboratory of Atmospheric Secondary Pollution, Guangzhou 510308, China.
authors.forename: Duo-Hong
authors.initials: DH
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, State University of New York, Albany, NY 12144-3445, USA.
authors.forename: Shao
authors.initials: S
authors.lastname: Lin
authors.affiliation: Department of Earth and Atmospheric Sciences, Saint Louis University, Saint Louis 63108, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: de Foy
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Hu
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Bo-Yi
authors.initials: BY
authors.lastname: Yang
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: Xu
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Yan-Peng
authors.initials: YP
authors.lastname: Tian
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Min
authors.initials: M
authors.lastname: Nian
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Bao
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Ya-Zhi
authors.initials: YZ
authors.lastname: Zhang
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: donggh5@mail.sysu.edu.cn.
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Dong
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis; D000397:Air Pollution / Q000032:analysis; D001794:Blood Pressure; D002648:Child; D002681:China; D002947:Cities; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D009585:Nitrogen Dioxide / Q000032:analysis; D016017:Odds Ratio; D010126:Ozone / Q000032:analysis; D052638:Particulate Matter / Q000032:analysis; D012044:Regression Analysis; D013458:Sulfur Dioxide / Q000032:analysis
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter; D013458:Sulfur Dioxide; D010126:Ozone; D009585:Nitrogen Dioxide
keywords: Ambient air pollution; Blood pressure; Children; China; Short-term exposure