title: Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive hydrogels.
abstract: One-step functionalization of alginate with boronic acid groups allowed spontaneous formation of biocompatible hydrogels under basic conditions without additional complementary molecules or crosslinking agents. The dynamic nature of boronate ester bonds formed with vicinal diols present on alginate pyranose rings provided remarkable self-healing, injectable and multi-stimuli responsive properties to the material.
authors.affiliation: Institute of Organic Chemistry, University of Regensburg, Universitaetsstr. 31, 93040 Regensburg, Germany. david.diaz@ur.de and Institut Charles Gerhardt, UMR 5253 CNRS/UM/ENSCM, Matériaux Avancés pour la Catalyse et la Santé, ENSCM, 8 rue Ecole Normale, 34296 Montpellier Cedex 5, France.
authors.forename: Asja
authors.initials: A
authors.lastname: Pettignano
authors.affiliation: IQAC-CSIC, Jordi Girona 18-26, Barcelona 08034, Spain and Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER BBN), Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Grijalvo
authors.affiliation: Institute of Organic Chemistry, University of Regensburg, Universitaetsstr. 31, 93040 Regensburg, Germany. david.diaz@ur.de.
authors.forename: Marleen
authors.initials: M
authors.lastname: Häring
authors.affiliation: IQAC-CSIC, Jordi Girona 18-26, Barcelona 08034, Spain and Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER BBN), Spain.
authors.forename: Ramon
authors.identifier: http://orcid.org/0000-0001-5383-9334
authors.initials: R
authors.lastname: Eritja
authors.affiliation: Institut Charles Gerhardt, UMR 5253 CNRS/UM/ENSCM, Matériaux Avancés pour la Catalyse et la Santé, ENSCM, 8 rue Ecole Normale, 34296 Montpellier Cedex 5, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Tanchoux
authors.affiliation: Institut Charles Gerhardt, UMR 5253 CNRS/UM/ENSCM, Matériaux Avancés pour la Catalyse et la Santé, ENSCM, 8 rue Ecole Normale, 34296 Montpellier Cedex 5, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Quignard
authors.affiliation: Institute of Organic Chemistry, University of Regensburg, Universitaetsstr. 31, 93040 Regensburg, Germany. david.diaz@ur.de and IQAC-CSIC, Jordi Girona 18-26, Barcelona 08034, Spain.
authors.forename: David
authors.identifier: http://orcid.org/0000-0002-0557-3364
authors.initials: D
authors.lastname: Díaz Díaz
mesh_terms: D000464:Alginates / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D005632:Fructose / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D020100:Hydrogels; D012212:Rheology
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D001897:Boronic Acids; D020100:Hydrogels; D005632:Fructose