title: A High Strength Self-Healable Antibacterial and Anti-Inflammatory Supramolecular Polymer Hydrogel.
abstract: There is a significant cost to mitigate the infection and inflammation associated with the implantable medical devices. The development of effective antibacterial and anti-inflammatory biomaterials with novel mechanism of action has become an urgent task. In this study, a supramolecular polymer hydrogel is synthesized by the copolymerization of N-acryloyl glycinamide and 1-vinyl-1,2,4-triazole in the absence of any chemical crosslinker. The hydrogel network is crosslinked through the hydrogen bond interactions between dual amide motifs in the side chain of N-acryloyl glycinamide. The prepared hydrogels demonstrate excellent mechanical properties-high tensile strength (≈1.2 MPa), large stretchability (≈1300%), and outstanding compressive strength (≈11 MPa) at swelling equilibrium state. A simulation study elaborates the changes of hydrogen bond interactions when 1-vinyl-1,2,4-triazole is introduced into the gel network. It is demonstrated that the introduction of 1-vinyl-1,2,4-triazole endowes the supramolecular hydrogels with self-repairability, thermoplasticity, and reprocessability over a lower temperature range for 3D printing of different shapes and patterns under simplified thermomelting extrusion condition. In addition, these hydrogels exhibit antimicrobial and anti-inflammatory activities, and in vitro cytotoxicity assay and histological staining following in vivo implantation confirm the biocompatibility of the hydrogel. These hydrogels with integrated multifunctions hold promising potential as an injectable biomaterial for treating degenerated soft supporting tissues.
authors.affiliation: School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300072, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, 48202, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.affiliation: School of Materials Science and Engineering, State Key Laboratory of Hollow Fiber Membrane Materials and Processes, Tianjin Polytechnic University, Tianjin, 300387, China.
authors.forename: Weigui
authors.initials: W
authors.lastname: Fu
authors.affiliation: School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300072, China.
authors.forename: Yinyu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300072, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
authors.affiliation: School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300072, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, 48202, USA.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Cao
authors.affiliation: School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300072, China.
authors.forename: Wenguang
authors.initials: W
authors.lastname: Liu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D005998:Glycine / Q000031:analogs & derivatives / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D011108:Polymers / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry
chemical_list: C533752:1-vinyl-1,2,4-triazole; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D011108:Polymers; D014230:Triazoles; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C018556:glycine amide; D005998:Glycine
keywords: antimicrobial; high strength; self-healing; supramolecular polymer hydrogels