title: Clinical response in patients with ovarian cancer treated with metronomic chemotherapy.
abstract: Ovarian cancer (OC) is the leading cause of death from gynaecological cancer. It is extremely hard to diagnose in the early stages and around 70% of patients present with advanced disease. Metronomic chemotherapy (MCT) is described as the chronic administration of, generally low, equally spaced, doses of chemotherapeutic drugs with therapeutic efficacy and low toxicity. This is an effective and low-cost way to treat several types of tumours, including ovarian cancer. Here, we present six cases of advanced ovarian cancer treated with MCT with low doses of cyclophosphamide, which showed clinical response and stable disease.
authors.affiliation: Experimental Oncology Section, Institute of Experimental Genetics, School of Medical Sciences, National University of Rosario, Rosario 2000, Argentina; National Scientific and Technical Research Council (CONICET), Rosario 2000, Argentina.; Italian Hospital of Rosario, Department of Clinical Oncology, Rosario 2000, Argentina.
authors.forename: Herman Andrés
authors.initials: HA
authors.lastname: Perroud
authors.affiliation: Experimental Oncology Section, Institute of Experimental Genetics, School of Medical Sciences, National University of Rosario, Rosario 2000, Argentina; National Scientific and Technical Research Council (CONICET), Rosario 2000, Argentina.; Research Council of the National University of Rosario (CIUNR), Rosario 2000, Argentina.
authors.forename: O Graciela
authors.initials: OG
authors.lastname: Scharovsky
authors.affiliation: Experimental Oncology Section, Institute of Experimental Genetics, School of Medical Sciences, National University of Rosario, Rosario 2000, Argentina.
authors.forename: Viviana Rosa
authors.initials: VR
authors.lastname: Rozados
authors.affiliation: Italian Hospital of Rosario, Department of Clinical Oncology, Rosario 2000, Argentina; Institute of Oncology of Rosario, Rosario 2000, Argentina.
authors.forename: Carlos María
authors.initials: CM
authors.lastname: Alasino
keywords: cyclophosphamide; metronomic chemotherapy; ovarian cancer