title: Brief Report: The ADOS Calibrated Severity Score Best Measures Autism Diagnostic Symptom Severity in Pre-School Children.
abstract: The severity of autism spectrum disorder (ASD) is often measured by co-occurring conditions, such as intellectual disability or language delay, rather than deficits in social interaction, and restricted interests and repetitive behaviors. The Autism Diagnostic Observation Schedule calibrated severity score (ADOS CSS) was created to facilitate comparison of the diagnostic features of ASD independent of related conditions over time. We examined the relationship between the ADOS CSS, ADOS total score, and clinician rated degree of impairment (DOI) in the Study to Explore Early Development. Like others, we confirmed that, among the measures we evaluated, the ADOS CSS was least influenced by developmental functioning and demographic factors and is therefore the best measure of core features of ASD in pre-school children.
authors.affiliation: National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 4770 Buford Highway MS E-86, Atlanta, GA, 30341, USA. lwiggins@cdc.gov.
authors.forename: Lisa D
authors.initials: LD
authors.lastname: Wiggins
authors.affiliation: Georgia State University School of Public Health, Atlanta, GA, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Barger
authors.affiliation: University of Colorado School of Medicine, Aurora, CO, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Moody
authors.affiliation: National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 4770 Buford Highway MS E-86, Atlanta, GA, 30341, USA.
authors.forename: Gnakub
authors.initials: G
authors.lastname: Soke
authors.affiliation: Center for Autism Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
authors.forename: Juhi
authors.initials: J
authors.lastname: Pandey
authors.affiliation: Center for Autism Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Levy
mesh_terms: D000067877:Autism Spectrum Disorder / Q000175:diagnosis*; D001321:Autistic Disorder / Q000175:diagnosis*; D002138:Calibration; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003710:Demography; D002658:Developmental Disabilities; D005260:Female; D006801:Humans; D008607:Intellectual Disability; D007398:Interpersonal Relations; D007805:Language Development Disorders; D008297:Male; D010554:Personality Disorders
keywords: Autism Diagnostic Observation Schedule; Autism spectrum disorder; Calibrated severity score; Symptom severity