title: The relationship of Interleukin-6 -174 G>C gene polymorphism in type 2 diabetic patients with and without diabetic foot ulcers in Turkish population.
abstract: OBJECTIVE
  We aims investigate Turkish type 2 diabetic patients with/without diabetic foot ulcers and healthy group and examined the contribution of Interleukin (IL)-6 -174 G>C gene polymorphism to the development of diabetic foot ulcers.
  
  
  METHODS
  The Interleukin (IL)-6 -174 G>C genotypes were determined prospectively in 50 patients with diabetic foot ulcers and 35 without diabetic foot ulcers and a control group of 119 healthy individuals. Genotyping of the Interleukin (IL)-6 -174 G>C gene polymorphisms for all individuals was performed by PCR-RFLP method.
  
  
  RESULTS
  The genotype IL6 distribution did differ between the control group (CC 13.3%, GC 66.7%, GG 20%) and type 2 diabetic patients (CC 2.4%, GC 47.1%, GG 50.6%) (P<0.001). The genotype IL6 distribution did not differ between type 2 diabetic patients group (CC 0%, GC 45.7%, GG 54.3%) and diabetic foot ulcers (CC 4%, GC 48%, 48%) (P>0.05). The frequency of the polymorphic G allele in between the control group and type 2 diabetic patients was no similar for the groups (58.4% and 74.1%, respectively) (p<0.05). The frequency of the polymorphic G allele in between the type 2 diabetic patients and diabetic foot ulcers was similar for the groups (77.1% and 72%, respectively) (p>0.05).
  
  
  CONCLUSIONS
  The gene polymorphism of Interleukin-6 -174 G>C and G allele are an risk factor for diabetes, but gene polymorphism of Interleukin-6 -174 G>C is not an independent risk factor for diabetic foot. Genetic factors in the pathogenesis of diabetic foot may also show any changes in different populations.
authors.affiliation: Ege University Medical School, Department of Endocrinology and Metabolic Diseases, Bornova, 35100 Izmir, Turkey. Electronic address: drmerdogan61@hotmail.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erdogan
authors.affiliation: Necmettin Erbakan University Medical School, Department of Endocrinology and Metabolic Diseases, Konya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kulaksizoglu
authors.affiliation: Ministry of Health, Numune Education and Research Hospital, Internal Medicine, Adana, Turkey.
authors.forename: Soner
authors.initials: S
authors.lastname: Solmaz
authors.affiliation: Ege University Medical School, Department of Pediatrics, Laboratory of Molecular Medicine, Bornova, Izmir, Turkey.
authors.forename: Afig
authors.initials: A
authors.lastname: Berdeli
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D017719:Diabetic Foot / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D011446:Prospective Studies; D014421:Turkey / Q000453:epidemiology
chemical_list: D015850:Interleukin-6
keywords: Diabetic; Foot; Polymorphism