title: Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue.
abstract: The synthesis and in vivo pharmacokinetic profile of an analogue of cyclosporine is disclosed. An acyclic congener was also profiled in in vitro assays to compare cell permeability. The compounds possess similar calculated and measured molecular descriptors however have different behaviors in an RRCK assay to assess cell permeability.
authors.affiliation: Pfizer Inc. Medicine Design, 610 Main Street, Cambridge, Massachusetts, 02155 USA. david.a.price@pfizer.com.
authors.forename: David A
authors.initials: DA
authors.lastname: Price
authors.forename: Heather
authors.initials: H
authors.lastname: Eng
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Farley
authors.forename: Gilles H
authors.initials: GH
authors.lastname: Goetz
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.forename: Zhaodong
authors.initials: Z
authors.lastname: Jiao
authors.forename: Amit S
authors.initials: AS
authors.lastname: Kalgutkar
authors.forename: Natasha M
authors.initials: NM
authors.lastname: Kablaoui
authors.forename: Bhagyashree
authors.initials: B
authors.lastname: Khunte
authors.forename: Spiros
authors.initials: S
authors.lastname: Liras
authors.forename: Chris
authors.initials: C
authors.lastname: Limberakis
authors.forename: Alan M
authors.initials: AM
authors.lastname: Mathiowetz
authors.forename: Roger B
authors.initials: RB
authors.lastname: Ruggeri
authors.forename: Jun-Min
authors.initials: JM
authors.lastname: Quan
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D008968:Molecular Conformation; D009842:Oligopeptides / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism
chemical_list: D009842:Oligopeptides; D016572:Cyclosporine