title: Recent Progress in Alzheimer's Disease Research, Part 3: Diagnosis and Treatment.
abstract: The field of Alzheimer's disease (AD) research has grown exponentially over the past few decades, especially since the isolation and identification of amyloid-β from postmortem examination of the brains of AD patients. Recently, the Journal of Alzheimer's Disease (JAD) put forth approximately 300 research reports which were deemed to be the most influential research reports in the field of AD since 2010. JAD readers were asked to vote on these most influential reports. In this 3-part review, we review the results of the 300 most influential AD research reports to provide JAD readers with a readily accessible, yet comprehensive review of the state of contemporary research. Notably, this multi-part review identifies the "hottest" fields of AD research providing guidance for both senior investigators as well as investigators new to the field on what is the most pressing fields within AD research. Part 1 of this review covers pathogenesis, both on a molecular and macro scale. Part 2 review genetics and epidemiology, and part 3 covers diagnosis and treatment. This part of the review, diagnosis and treatment, reviews the latest diagnostic criteria, biomarkers, imaging, and treatments in AD.
authors.affiliation: Department of Chemistry, Lakehead University, Thunder Bay, ON, Canada.|Thunder Bay Regional Research Institute, Thunder Bay, ON, Canada.|Department of Biology, University of Waterloo, Waterloo, ON, Canada.
authors.forename: Francis T
authors.initials: FT
authors.lastname: Hane
authors.affiliation: Department of Biology, University of Waterloo, Waterloo, ON, Canada.
authors.forename: Morgan
authors.initials: M
authors.lastname: Robinson
authors.affiliation: Department of Biology, University of Waterloo, Waterloo, ON, Canada.
authors.forename: Brenda Y
authors.initials: BY
authors.lastname: Lee
authors.affiliation: Thunder Bay Regional Research Institute, Thunder Bay, ON, Canada.
authors.forename: Owen
authors.initials: O
authors.lastname: Bai
authors.affiliation: Department of Biology, University of Waterloo, Waterloo, ON, Canada.|Department of Physics and Astronomy, University of Waterloo, Waterloo, ON, Canada.
authors.forename: Zoya
authors.initials: Z
authors.lastname: Leonenko
authors.affiliation: Department of Chemistry, Lakehead University, Thunder Bay, ON, Canada.|Thunder Bay Regional Research Institute, Thunder Bay, ON, Canada.|Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
authors.forename: Mitchell S
authors.initials: MS
authors.lastname: Albert
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis* / Q000628:therapy*; D015415:Biomarkers / Q000378:metabolism*; D035843:Biomedical Research; D006801:Humans; D059906:Neuroimaging / Q000379:methods*
chemical_list: D015415:Biomarkers
keywords: Alzheimer’s disease; MRI; PET; biomarkers; diagnosis; mild cognitive impairment; treatment