title: Erythrophagocytosis by blasts in a case ofde novoacute monoblastic leukemia with rare but characteristic t(8;16).
abstract: Erythrophagocytosis by leukemic blasts is a rare phenomenon. We report a case of a female diagnosed with acute monoblastic leukemia with leukemic blasts that were CD34 and CD117 negative, showing erythrophagocytosis, vacoulations, and a rare t(8;16) on bone marrow karyotype which is associated with a poor prognosis despite intensive chemotherapy. Meticulous bone marrow examination in such a scenario may point towards the presence of t(8;16) and help clinicians take a well-informed clinical decision.
authors.affiliation: Department of Hematopathology and Genetics, AMPATH, Nallagandla, Serilingampally Hyderabad, Telangana, India.
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Department of Medical Oncology, Manipal Super Specialty Hospital, Vijaywada, Andhra Pradesh, India.
authors.forename: G K
authors.initials: GK
authors.lastname: Reddy
authors.affiliation: Department of Hematopathology and Genetics, AMPATH, Nallagandla, Serilingampally Hyderabad, Telangana, India.
authors.forename: M
authors.initials: M
authors.lastname: Goyal
authors.affiliation: Department of Hematopathology and Genetics, AMPATH, Nallagandla, Serilingampally Hyderabad, Telangana, India.
authors.forename: M R
authors.initials: MR
authors.lastname: Kasaragadda
mesh_terms: D000328:Adult; D000754:Anemia, Refractory, with Excess of Blasts / Q000401:mortality / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D002869:Chromosome Aberrations; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000401:mortality / Q000473:pathology*; D009154:Mutation