title: First steps to creating a platform for high throughput simulation of TTFields.
abstract: Tumor Treating Fields (TTFields) are low intensity alternating electric fields in the 100-500 KHz frequency range that are known to have an anti-mitotic effect on cancerous cells. In the USA, TTFields are approved by the Food and Drug Administration (FDA) for the treatment of glioblastoma (GBM) in both the newly diagnosed and recurrent settings. Optimizing treatment with TTFields requires a deep understanding of how TTFields distribute within the brain. To address this issue, simulations using realistic head models have been performed. However, the preparation of such models is time-consuming and requires a high level of expertise, limiting the usefulness of these models for systematic studies in which the testing of multiple cases is required. Here we present a platform for rapidly simulating TTFields distributions in multiple scenarios. This platform enables high throughput computational simulations to be performed, allowing comparison of field distributions within the head in multiple clinically relevant scenarios. The simulation setup is simple and intuitive, allowing non-expert users to run simulations and evaluate results, thereby providing a valuable tool for studying how to optimize TTFields delivery in the clinic.
authors.forename: Hadas Sara
authors.initials: HS
authors.lastname: Hershkovich
authors.forename: Zeev
authors.initials: Z
authors.lastname: Bomzon
authors.forename: Cornelia
authors.initials: C
authors.lastname: Wenger
authors.forename: Noa
authors.initials: N
authors.lastname: Urman
authors.forename: Aafia
authors.initials: A
authors.lastname: Chaudhry
authors.forename: Dario
authors.initials: D
authors.lastname: Garcia-Carracedo
authors.forename: Eilon D
authors.initials: ED
authors.lastname: Kirson
authors.forename: Uri
authors.initials: U
authors.lastname: Weinberg
authors.forename: Yoram
authors.initials: Y
authors.lastname: Wassermann
authors.forename: Yoram
authors.initials: Y
authors.lastname: Palti
mesh_terms: D001921:Brain; D001932:Brain Neoplasms / Q000628:therapy*; D003198:Computer Simulation; D004599:Electric Stimulation Therapy; D004560:Electricity; D005909:Glioblastoma / Q000628:therapy*; D006257:Head; D006801:Humans; D008962:Models, Theoretical