title: Fibrin in Reproductive Tissue Engineering: A Review on Its Application as a Biomaterial for Fertility Preservation.
abstract: In recent years, reproductive medicine has made good use of tissue engineering and regenerative medicine techniques to develop alternatives to restore fertility in cancer patients. For young female cancer patients who cannot undergo any of the currently applied strategies due to the possible presence of malignant cells in their ovaries, the challenge is creating an in vitro or in vivo artificial ovary using carefully selected biomaterials. Thanks to its numerous qualities, fibrin has been widely used as a scaffold material for fertility preservation applications. The goal of this review is to examine and discuss the applications and advantages of this biopolymer for fertility restoration in cancer patients, and consider the main results achieved so far.
authors.affiliation: Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium.
authors.forename: M C
authors.identifier: http://orcid.org/0000-0002-0445-8946
authors.initials: MC
authors.lastname: Chiti
authors.affiliation: Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium. marie-madeleine.dolmans@uclouvain.be.|Gynecology Department, Cliniques Universitaires Saint-Luc, 1200, Brussels, Belgium. marie-madeleine.dolmans@uclouvain.be.
authors.forename: M M
authors.initials: MM
authors.lastname: Dolmans
authors.affiliation: Society for Research into Infertility, Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Donnez
authors.affiliation: Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium.
authors.forename: C A
authors.initials: CA
authors.lastname: Amorim
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D005260:Female; D005298:Fertility; D005337:Fibrin / Q000627:therapeutic use*; D006801:Humans; D012099:Reproductive Techniques; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D005337:Fibrin
keywords: In vitro artificial ovary; Ovarian tissue transplantation; Tissue engineering; Transplantable artificial ovary