title: Serum oxygen radical activity and total antioxidation capacity are related with severities of surgical patient with sepsis: Prospective pilot study.
abstract: The purpose of this pilot study was to evaluate the correlation between clinical severity and serum oxygen radical activity (ORA) and total antioxidation capacity (TAC) in critically ill surgical patients with sepsis.
  
  
  
  The prospective observational study was performed in surgical intensive care unit (SICU) patients with intra-abdominal sepsis. Serum ORA and TAC levels were measured using a spectrophotometry-based antioxidant assay machine. Serum selenium and zinc levels and plasma glutamine concentrations were also determined. Sequential organ failure assessment (SOFA) and multiple organ dysfunction (MOD) scores were calculated to evaluate the severity. Blood tests and severity scores were assessed on days 1, 3, and 7 in the SICU.
  
  
  
  Twenty-seven patients were included. The mean APACHE II score was 22.4. The in-hospital mortality rate was 14.8%. Serum TAC levels correlated positively with SOFA and MOD scores on SICU days 1, 3 and 7, and serum ORA correlated negatively with SOFA and MOD scores on day 3. Serum zinc and selenium levels were lower than normal throughout the observation period. However, there was no significant relationship in clinical severity.
  
  
  
  Serum TAC level may be a useful biomarker to predict severity of critically ill surgical patients with sepsis.
authors.affiliation: Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Jang
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
authors.forename: Hongjin
authors.initials: H
authors.lastname: Shim
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: jakii@yuhs.ac.
authors.forename: Jae Gil
authors.initials: JG
authors.lastname: Lee
mesh_terms: D018806:APACHE; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D016638:Critical Illness; D005260:Female; D005973:Glutamine / Q000378:metabolism; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011183:Postoperative Complications / Q000401:mortality*; D011446:Prospective Studies; D017382:Reactive Oxygen Species / Q000378:metabolism*; D018805:Sepsis / Q000401:mortality*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D017382:Reactive Oxygen Species; D005973:Glutamine
keywords: Critically ill surgical patient; Oxygen radical activity; Sepsis; Total antioxidation capacity