title: [GENOMIC VARIABILITY IN PATIENTS WITH DUCTAL FORM OF BREAST CANCER AND THE POSSIBILITY OF CORRECTION THE PEPTIDE BIOREGULATOR AND METAL IONS].
abstract: Level of genome stability (structural aberrations, aneuploidy and fragile sites) was studied in cells of the lymphocyte culture of ductal breast cancer patients (DBC). Was studied the correctional influence of separate and combinative action of peptide bioregulator (Ala-Glu-Asp-Gly) and heavy metal - nickel. It is shown that DBC patients are characterized by high level of genome instability, which is the result of the chromatin changing state. The used tests makes it possible to conclude that in the case of this form of cancer subordinates to specific epigenetic variation as a hetero- also euchromatic regions of genome. The agents - peptide bioregulator (Ala-Glu-Asp-Gly) and nickel ions, used in cell culture of ductal breast cancer patients, revealed the protective effect what indicates the prospects to further study for their involving purpose in combined therapy of this form of cancer.
authors.affiliation: Iv. Javakhishvili Tbilisi State University, Department of Genetics, Tbilisi, Georgia; Department of Physics of Biological Systems. E. Andronikashvili Institute of Physics, Tbilisi, Georgia; K. Madichi Centre of Oncology, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Jokhadze
authors.affiliation: Iv. Javakhishvili Tbilisi State University, Department of Genetics, Tbilisi, Georgia; Department of Physics of Biological Systems. E. Andronikashvili Institute of Physics, Tbilisi, Georgia.
authors.forename: J
authors.initials: J
authors.lastname: Monaselidze
authors.affiliation: Iv. Javakhishvili Tbilisi State University, Department of Genetics, Tbilisi, Georgia; Department of Physics of Biological Systems. E. Andronikashvili Institute of Physics, Tbilisi, Georgia.
authors.forename: G
authors.initials: G
authors.lastname: Nemsadze
authors.affiliation: Iv. Javakhishvili Tbilisi State University, Department of Genetics, Tbilisi, Georgia; Department of Physics of Biological Systems. E. Andronikashvili Institute of Physics, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Buadze
authors.affiliation: Iv. Javakhishvili Tbilisi State University, Department of Genetics, Tbilisi, Georgia; Department of Physics of Biological Systems. E. Andronikashvili Institute of Physics, Tbilisi, Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Gaiozishvili
authors.affiliation: Iv. Javakhishvili Tbilisi State University, Department of Genetics, Tbilisi, Georgia; Department of Physics of Biological Systems. E. Andronikashvili Institute of Physics, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Lezhava
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D002413:Cations, Divalent; D002843:Chromatin / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations / Q000187:drug effects; D043283:Chromosome Fragile Sites; D004357:Drug Synergism; D005260:Female; D014644:Genetic Variation; D006801:Humans; D009532:Nickel / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D002413:Cations, Divalent; D002843:Chromatin; D009842:Oligopeptides; C022838:nickel chloride; D009532:Nickel; C421253:alanyl-glutamyl-aspartyl-glycine