title: Preparation and characterization of alloys of the Ti-15Mo-Nb system for biomedical applications.
abstract: In the development of new metallic biomaterials, the Ti-15Mo alloy has great prominence because of its excellent corrosion resistance and good combination of mechanical properties. In this study, the element niobium was added to the Ti-15Mo alloy, forming the Ti-15Mo-Nb system for the purpose of improving their properties and promoting its application as a biomaterial. These alloys are very promising to use as biomedical implants, because they integrate a new class of titanium alloys without the presence of aluminum and vanadium, which may cause cytotoxic effects. The alloys were produced by arc-melting and characterized by density, X-ray diffraction, scanning electron microscopy, microhardness, elastic modulus, corrosion, and cytotoxicity assays. The developed alloys have β phase predominance (with bcc crystalline structure). The addition of niobium decreases the microhardness and elastic modulus, with values around 80 GPa, which is well below that of the metallic alloys used commercially for this type of application. Very low passive current densities were found for all alloys studied showing that the passive film on these alloys is highly protective. In vitro cytotoxicity tests revealed that the introduction of niobium did not cause cytotoxic effects in the studied alloys. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 639-648, 2018.
authors.affiliation: IFSP-Instituto Federal de São Paulo - Câmpus Avançado Tupã, 17.607-220, Tupã, SP, Brazil.|UNESP-Univ Estadual Paulista, Laboratório de Anelasticidade e Biomateriais, 17.033-360, Bauru, SP, Brazil.|IBTN/Br-Institute of Biomaterials, Tribocorrosion and Nanomedicine-Brazilian Branch, 17.033-360, Bauru, SP, Brazil.
authors.forename: J R S
authors.initials: JRS
authors.lastname: Martins Júnior
authors.affiliation: USP-Univ São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciências Biológicas e Bioquímica, 17.012-901, Bauru, SP, Brazil.
authors.forename: A A
authors.initials: AA
authors.lastname: Matos
authors.affiliation: IBTN/Br-Institute of Biomaterials, Tribocorrosion and Nanomedicine-Brazilian Branch, 17.033-360, Bauru, SP, Brazil.|USP-Univ São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciências Biológicas e Bioquímica, 17.012-901, Bauru, SP, Brazil.
authors.forename: R C
authors.initials: RC
authors.lastname: Oliveira
authors.affiliation: USP-Univ São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciências Biológicas e Bioquímica, 17.012-901, Bauru, SP, Brazil.
authors.forename: M A R
authors.initials: MAR
authors.lastname: Buzalaf
authors.affiliation: IPEN-Instituto de Pesquisas Energéticas e Nucleares, Centro de Ciência e Tecnologia de Materiais, 05508-000, São Paulo, SP, Brazil.
authors.forename: I
authors.initials: I
authors.lastname: Costa
authors.affiliation: UNESP-Univ Estadual Paulista, Laboratório de Anelasticidade e Biomateriais, 17.033-360, Bauru, SP, Brazil.|IBTN/Br-Institute of Biomaterials, Tribocorrosion and Nanomedicine-Brazilian Branch, 17.033-360, Bauru, SP, Brazil.
authors.forename: L A
authors.initials: LA
authors.lastname: Rocha
authors.affiliation: UNESP-Univ Estadual Paulista, Laboratório de Anelasticidade e Biomateriais, 17.033-360, Bauru, SP, Brazil.|IBTN/Br-Institute of Biomaterials, Tribocorrosion and Nanomedicine-Brazilian Branch, 17.033-360, Bauru, SP, Brazil.
authors.forename: C R
authors.identifier: 0000-0002-3336-309X
authors.initials: CR
authors.lastname: Grandini
mesh_terms: D000497:Alloys / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D020811:Biomedical Technology; D002470:Cell Survival / Q000187:drug effects; D003343:Corrosion; D055119:Elastic Modulus; D004563:Electrochemistry; D006244:Hardness; D051379:Mice; D041681:NIH 3T3 Cells; D009556:Niobium / Q000737:chemistry*; D019736:Prostheses and Implants; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; C525450:titanium molybdenum alloy; D009556:Niobium
keywords: Ti alloys; biomaterials; corrosion; elastic modulus