title: Follow YOUR Heart: development of an evidence-based campaign empowering older women with HIV to participate in a large-scale cardiovascular disease prevention trial.
abstract: Women's under-representation in HIV and cardiovascular disease (CVD) research suggests a need for novel strategies to ensure robust representation of women in HIV-associated CVD research.
  
  
  
  To elicit perspectives on CVD research participation among a community-sample of women with or at risk for HIV, and to apply acquired insights toward the development of an evidence-based campaign empowering older women with HIV to participate in a large-scale CVD prevention trial.
  
  
  
  In a community-based setting, we surveyed 40 women with or at risk for HIV about factors which might facilitate or impede engagement in CVD research. We applied insights derived from these surveys into the development of the Follow YOUR Heart campaign, educating women about HIV-associated CVD and empowering them to learn more about a multi-site HIV-associated CVD prevention trial: REPRIEVE.
  
  
  
  Endorsed best methods for learning about a CVD research study included peer-to-peer communication (54%), provider communication (46%) and video-based communication (39%). Top endorsed non-monetary reasons for participating in research related to gaining information (63%) and helping others (47%). Top endorsed reasons for not participating related to lack of knowledge about studies (29%) and lack of request to participate (29%). Based on survey results, the REPRIEVE Follow YOUR Heart campaign was developed. Interwoven campaign components (print materials, video, web presence) offer provider-based information/knowledge, peer-to-peer communication, and empowerment to learn more. Campaign components reflect women's self-identified motivations for research participation - education and altruism.
  
  
  
  Investigation of factors influencing women's participation in HIV-associated CVD research may be usefully applied to develop evidence-based strategies for enhancing women's enrollment in disease-specific large-scale trials. If proven efficacious, such strategies may enhance conduct of large-scale research studies across disciplines.
authors.affiliation: a Program in Nutritional Metabolism , Mass General Hospital and Harvard Medical School , Boston , MA , USA.
authors.forename: Markella V
authors.initials: MV
authors.lastname: Zanni
authors.affiliation: a Program in Nutritional Metabolism , Mass General Hospital and Harvard Medical School , Boston , MA , USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Fitch
authors.affiliation: a Program in Nutritional Metabolism , Mass General Hospital and Harvard Medical School , Boston , MA , USA.
authors.forename: Corinne
authors.initials: C
authors.lastname: Rivard
authors.affiliation: a Program in Nutritional Metabolism , Mass General Hospital and Harvard Medical School , Boston , MA , USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Sanchez
authors.affiliation: b Cardiology Division and Duke Clinical Research Institute , Duke University School of Medicine, Duke University Hospital , Durham , NC , USA.
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Douglas
authors.affiliation: a Program in Nutritional Metabolism , Mass General Hospital and Harvard Medical School , Boston , MA , USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Grinspoon
authors.affiliation: c Harvard T.H. Chan School of Public Health , Center for Biostatistics in AIDS Research , Boston , MA , USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Smeaton
authors.affiliation: d Division of Infectious Diseases , University of California, Los Angeles CARE Hospital and University of California, Los Angeles Medical School , Los Angeles , CA , USA.
authors.forename: Judith S
authors.initials: JS
authors.lastname: Currier
authors.affiliation: a Program in Nutritional Metabolism , Mass General Hospital and Harvard Medical School , Boston , MA , USA.|e Yvonne L. Munn Center for Nursing Research , Mass General Hospital , Boston , MA , USA.
authors.forename: Sara E
authors.initials: SE
authors.lastname: Looby
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D003153:Community Health Services; D003430:Cross-Sectional Studies; D019317:Evidence-Based Medicine / Q000379:methods; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006293:Health Promotion / Q000379:methods; D006801:Humans; D008875:Middle Aged; D010353:Patient Education as Topic; D010358:Patient Participation; D018579:Patient Selection; D012737:Sex Factors; D061108:Social Media; D011795:Surveys and Questionnaires
keywords: Clinical trials; Community-based research; HIV-associated cardiovascular disease; REPRIEVE; Research participation; Sex differences; Women