title: Seroprevalence of Kaposi's sarcoma-associated herpesvirus among HIV-infected Uygurs in Xinjiang, China.
abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), which primarily affects human immunodeficiency virus (HIV)-infected adults with advanced immunodeficiency. Xinjiang province in China is an endemic area for Kaposi's sarcoma (KS), however, currently, only limited data for KSHV infection among HIV-infected individuals living in this endemic area is available. A cross-sectional study of 86 HIV positive participants was conducted in Xinjiang, China from 2014 through 2015. Plasma samples were collected and screened for KSHV and HIV infection. HIV pol gene and KSHV ORF-K1 gene were amplified and sequenced, genotypes were determined by phylogenetic analysis. Over all, prevalence was 48.9% (42/86; 95%CI 38.4-59.3%) for KSHV. Only CRF07_BC subtype has been identified among all these HIV positive individuals, while the subtype A and C of KSHV were detected in the participants. Meanwhile, we found that those with high CD4 counts (>500) showed a lower anti-KSHV titer, compared with other groups. Our study indicated a high prevalence of KSHV among HIV positive individuals in Xinjiang, China. Thus, management of HIV/AIDS patients should include KSHV screen and should consider the risk of KSHV-associated malignancies.
authors.affiliation: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.|Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, China.|Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
authors.forename: Zhenqiu
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.|Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, China.|Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
authors.forename: Qiwen
authors.initials: Q
authors.lastname: Fang
authors.affiliation: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.|Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, China.|Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
authors.forename: Sujuan
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Nebraska Center of Virology and the School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska.
authors.forename: Veenu
authors.initials: V
authors.lastname: Minhas
authors.affiliation: Nebraska Center of Virology and the School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska.
authors.forename: Charles
authors.initials: C
authors.lastname: Wood
authors.affiliation: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.|Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, China.|Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
authors.forename: Na
authors.initials: N
authors.lastname: He
authors.affiliation: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.|Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, China.|Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
authors.forename: Tiejun
authors.identifier: 0000-0002-5187-7393
authors.initials: T
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D005838:Genotype; D060005:Genotyping Techniques; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1 / Q000145:classification / Q000235:genetics; D006566:Herpesviridae Infections / Q000453:epidemiology*; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D017422:Sequence Analysis, DNA; D016036:Seroepidemiologic Studies; D014759:Viral Envelope Proteins / Q000235:genetics; D055815:Young Adult; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics; D014764:Viral Proteins
chemical_list: D000914:Antibodies, Viral; D008565:Membrane Proteins; D014759:Viral Envelope Proteins; D054302:pol Gene Products, Human Immunodeficiency Virus; C111600:K1 protein, Human herpesvirus 8; D014764:Viral Proteins
keywords: China; HIV; KSHV