title: Multifrequency-swept optical coherence microscopy for highspeed full-field tomographic vibrometry in biological tissues.
abstract: Because conventional laser Doppler vibrometry or Doppler optical coherence tomography require mechanical scanning probes that cannot simultaneously measure the wide-range dynamics of bio-tissues, a multifrequency-swept optical coherence microscopy with wide-field heterodyne detection technique was developed. A 1024 × 1024 × 2000 voxel volume was acquired with an axial resolution of ~1.8 μm and an acquisition speed of 2 s. Vibration measurements at 10 kHz were performed over a wide field of view. Wide-field tomographic vibration measurements of a mouse tympanic membrane are demonstrated to illustrate the applicability of this method to live animals.
authors.affiliation: Niigata University, Department of Electrical and Electronics Engineering, 8050 Ikarashi-2, Niigata 950-2181, Japan; AMED-CTRST, AMED, Japan.
authors.forename: Samuel
authors.initials: S
authors.lastname: Choi
authors.affiliation: Niigata University, Department of Electrical and Electronics Engineering, 8050 Ikarashi-2, Niigata 950-2181, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Sato
authors.affiliation: AMED-CTRST, AMED, Japan; Niigata University, School of Medicine, Department of Molecular Physiology, 757 Ichibancho, Asahimachi, Niigata 951-8510, Japan.
authors.forename: Takeru
authors.initials: T
authors.lastname: Ota
authors.affiliation: AMED-CTRST, AMED, Japan; Niigata University, School of Medicine, Department of Molecular Physiology, 757 Ichibancho, Asahimachi, Niigata 951-8510, Japan; Niigata University, Center for Transdisciplinary Research, 8050 Ikarashi-2, Niigata 950-2181, Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Nin
authors.affiliation: Niigata University, Department of Electrical and Electronics Engineering, 8050 Ikarashi-2, Niigata 950-2181, Japan; AMED-CTRST, AMED, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Muramatsu
authors.affiliation: AMED-CTRST, AMED, Japan; Niigata University, School of Medicine, Department of Molecular Physiology, 757 Ichibancho, Asahimachi, Niigata 951-8510, Japan; Niigata University, Center for Transdisciplinary Research, 8050 Ikarashi-2, Niigata 950-2181, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hibino
keywords: (110.4500) Optical coherence tomography; (120.3180) Interferometry; (120.7280) Vibration analysis; (170.0110) Imaging systems