title: Dietary Fat Inflames CD4+T Cell Memory in Obesity.
abstract: T cells promote inflammation in obesity, but how metabolic stress associated with obesity alters T cell responses remains unclear. In this issue of Cell Metabolism,Mauro et al. (2017) demonstrate that saturated fatty acids directly increase effector-memory T cell formation by amplifying T cell antigen-receptor-induced PI3K/Akt signaling.
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Chapman
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: hongbo.chi@stjude.org.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Chi
mesh_terms: D015496:CD4-Positive T-Lymphocytes; D004041:Dietary Fats; D005227:Fatty Acids; D006801:Humans; D009765:Obesity; D019869:Phosphatidylinositol 3-Kinases; D013601:T-Lymphocytes
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D019869:Phosphatidylinositol 3-Kinases