title: A wide range and high sensitivity four-channel compact electrochemical biosensor for neurotransmitter detection on a microfluidic platform.
abstract: We present a four-channel, high-sensitivity and linearity electrochemical biosensor for neurotransmitter (NT) detection and measurement. Using a multi-channel microfluidic platform makes this biosensor capable of detecting NT-related currents going from nanoamperes to milliamperes, with a sensitivity of the order of picoamperes. Moreover, by using a fully differential potentiostat architecture, the biosensor offers a high common-mode rejection ratio (90 dB), making it appropriate for low-noise and high-sensitive applications. The system was implemented on a 15 mm × 15 mm PCB with direct interface to the microfluidic chambers. It was calibrated with a 5 mM ferrocyanide solution and successfully tested with dopamine at three concentrations. The system shows a minimum sensistivity of 100 pA and consumes 60 mW.
authors.forename: Elnaz
authors.initials: E
authors.lastname: Ghodsevali
authors.forename: Hamza
authors.initials: H
authors.lastname: Landari
authors.forename: Mounir
authors.initials: M
authors.lastname: Boukadoum
authors.forename: Benoit
authors.initials: B
authors.lastname: Gosselin
authors.forename: Amine
authors.initials: A
authors.lastname: Miled
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D004553:Electric Conductivity; D004563:Electrochemistry; D004867:Equipment Design; D005295:Ferrocyanides / Q000737:chemistry; D056656:Lab-On-A-Chip Devices; D057230:Limit of Detection; D018377:Neurotransmitter Agents / Q000032:analysis*
chemical_list: D005295:Ferrocyanides; D018377:Neurotransmitter Agents; C020354:hexacyanoferrate II