title: Major Complex Abdominal Wall Repair in Contaminated Fields with Use of a Non-cross-linked Biologic Mesh: A Dual-Institutional Experience.
abstract: Data on the use of biologic mesh in abdominal wall repair in complex cases remain sparse. Aim of this study was to evaluate a non-cross-linked porcine acellular dermal matrix for repair of complex contaminated abdominal wall defects.
  
  
  
  Retrospective observational cohort study of consecutive patients undergoing abdominal wall repair with use of Strattice™ Reconstructive Tissue Matrix (LifeCell Corporation, Oxford, UK) between January 2011 and February 2015 at two National Intestinal Failure Units.
  
  
  
  Eighty patients were identified. Indications for abdominal wall repair included enterocutaneous fistula takedown (n = 50), infected synthetic mesh removal (n = 9), restoration of continuity or creation of a stoma with concomitant ventral hernia repair (n = 12), and others (n = 9). The median defect area was 143.0 cm2(interquartile range or IQR 70.0-256.0 cm2). All had a grade III or IV hernia. Component separation technique (CST) was performed in 54 patients (68%). Complete fascial closure was not possible despite CST and biologic mesh-assisted traction (bridged repair) in 20 patients (25%). In-hospital mortality was 1%. Thirty-six patients (45%) developed a wound infection. None required mesh removal. Of 76 patients with a median clinical follow-up of 7 months (IQR 4-15) available for analysis, 10 patients (13%) developed a hernia recurrence, of whom 3 had undergone bridged repairs. Seven patients developed a postoperative (recurrent) fistula (9%).
  
  
  
  Repair of challenging and contaminated abdominal wall defects can be done effectively with non-cross-linked biologic mesh and component separation technique without the need for mesh removal despite wound infections.
authors.affiliation: Department of Surgery, Academic Medical Centre, 1105 AZ, Amsterdam, The Netherlands. j.j.atema@amc.nl.
authors.forename: J J
authors.initials: JJ
authors.lastname: Atema
authors.affiliation: Department of Surgery, St Mark's Hospital, London, UK.
authors.forename: E J
authors.initials: EJ
authors.lastname: Furnée
authors.affiliation: Department of Surgery, St Mark's Hospital, London, UK.
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.affiliation: Department of Surgery, St Mark's Hospital, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Warusavitarne
authors.affiliation: Department of Surgery, Academic Medical Centre, 1105 AZ, Amsterdam, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Tanis
authors.affiliation: Department of Surgery, Academic Medical Centre, 1105 AZ, Amsterdam, The Netherlands.
authors.forename: W A
authors.initials: WA
authors.lastname: Bemelman
authors.affiliation: Department of Surgery, St Mark's Hospital, London, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Vaizey
authors.affiliation: Department of Surgery, Academic Medical Centre, 1105 AZ, Amsterdam, The Netherlands.
authors.forename: M A
authors.initials: MA
authors.lastname: Boermeester
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006555:Hernia, Ventral / Q000601:surgery; D017052:Hospital Mortality; D006801:Humans; D007412:Intestinal Fistula / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D013526:Surgical Mesh; D013552:Swine