title: Evaluation of thiol-disulphide homeostasis in radiation workers.
abstract: To evaluate thiol-disulphide homeostasis - a novel, easily calculated, readily available, and relatively cheap oxidative stress marker - in radiation workers and compare the results with healthy controls.
  
  
  
  A total of 108 participants were enrolled in the study including 63 hospital workers occupationally exposed to ionizing radiation in the units of interventional radiology, interventional cardiology and nuclear medicine. A control group consisted of 45 individuals staff in the same hospital. Serum thiol-disulphide homeostasis measurement was investigated via the spectrophotometric method newly described by Erel and Neşelioğlu.
  
  
  
  The mean serum native thiol levels of radiation workers (528.96 ± 86.42 μmol/l) was significantly lower than control subjects (561.05 ± 104.83 μmol/l) (p = .045). The mean serum total thiol levels of radiation workers (547.70 ± 91.50 μmol/l) was lower than control subjects (580.36 ± 112.24 μmol/l). Nevertheless, there was no significant difference between total thiol of exposed workers and controls.
  
  
  
  The results show that long-term low dose ionizing radiation may lead to oxidative stress and have side-effects in antioxidant thiol groups. We may suggest supporting radiation workers by safe antioxidant nutritional formulations and following up via both physical dosimetry and biodosimetric methods.
authors.affiliation: a Department of Radiology , Erzincan University Mengucek Gazi Training and Research Hospital , Erzincan , Turkey.
authors.forename: Ural
authors.initials: U
authors.lastname: Koc
authors.affiliation: b Department of Radiology , Kırıkkale University , Kırıkkale , Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Tan
authors.affiliation: c Section of Cardiology , Ankara Yuksek Ihtisas Training and Research Hospital , Ankara , Turkey.
authors.forename: Ahmet Goktug
authors.initials: AG
authors.lastname: Ertem
authors.affiliation: d Department of Radiology , Yıldırım Beyazıt University , Ankara , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gumus
authors.affiliation: e Section of Biochemistry , Ankara Ataturk Training and Research Hospital , Ankara , Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Ozbek
authors.affiliation: f Department of Biochemistry , Yıldırım Beyazıt University , Ankara , Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
mesh_terms: D000293:Adolescent; D000328:Adult; D001681:Biological Assay / Q000379:methods; D004220:Disulfides / Q000097:blood*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006706:Homeostasis / Q000502:physiology / Q000528:radiation effects; D006801:Humans; D008297:Male; D008505:Medical Staff, Hospital / Q000706:statistics & numerical data*; D008875:Middle Aged; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D018384:Oxidative Stress / Q000502:physiology / Q000528:radiation effects*; D011829:Radiation Dosage; D000069079:Radiation Exposure / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013438:Sulfhydryl Compounds / Q000097:blood*; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D004220:Disulfides; D013438:Sulfhydryl Compounds
keywords: Thiol; disulphide; radiation workers