title: Efficacy of phase 3 trial of RTS, S/AS01 malaria vaccine: The need for an alternative development plan.
abstract: Although vaccines would be the ideal tool for control, prevention, elimination, and eradication of many infectious diseases, developing of parasites vaccines such as malaria vaccine is very complex. The most advanced malaria vaccine candidate RTS,S, a pre-erythrocytic vaccine, has been recommended for licensure by EMEA. The results of this phase III trial suggest that this candidate malaria vaccine has relatively little efficacy, and the vaccine apparently will not meet the goal of malaria eradication by itself. Since there are many vaccine candidates in the pipeline1that are being evaluated in vaccine trials, further study on using of alternative parasite targets and vaccination strategies are highly recommended.
authors.affiliation: a Pediatric Infectious Disease Research Center , Tehran University of Medical Science , Tehran , Iran.|b Center for Research of Endemic Parasites of Iran (CREPI) , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Mahmoudi
authors.affiliation: b Center for Research of Endemic Parasites of Iran (CREPI) , Tehran University of Medical Sciences , Tehran , Iran.|c Department of Medical Parasitology and Mycology , School of Public Heath, Tehran, University of Medical Science , Tehran , Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Keshavarz
mesh_terms: D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D005260:Female; D006801:Humans; D007223:Infant; D008288:Malaria / Q000517:prevention & control; D017780:Malaria Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D016778:Malaria, Falciparum / Q000517:prevention & control*; D008297:Male; D010963:Plasmodium falciparum / Q000276:immunology; D014611:Vaccination; D064166:Vaccine Potency
chemical_list: D017780:Malaria Vaccines
keywords: RTS; S/AS01 malaria vaccine; efficacy; vaccine development