title: Trained Immunity: An Ancient Way of Remembering.
abstract: The innate arm of the immune system has generally been regarded as primitive and non-specific and, in contrast to adaptive immunity, not to possess memory. Here we review the growing body of evidence that innate immunity has an important capacity to adapt, a de facto innate immune memory (also termed trained immunity), and this provides broad protection against infections.
authors.affiliation: Department of Internal Medicine, Radboud University Medical Centre, PO box 9101, 6500HB Nijmegen, the Netherlands. Electronic address: mihai.netea@radboudumc.nl.
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
authors.affiliation: Department of Internal Medicine, Radboud University Medical Centre, PO box 9101, 6500HB Nijmegen, the Netherlands. Electronic address: jos.vandermeer@radboudumc.nl.
authors.forename: Jos W M
authors.initials: JW
authors.lastname: van der Meer
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory
keywords: cytokines; infections; innate immune memory; trained immunity; vertebrate immunity