title: Drug-Loaded Polymeric Nanoparticles for Cancer Stem Cell Targeting.
abstract: Cancer stem cells (CSCs) have been reported to play critical roles in tumor initiation, propagation, and regeneration of cancer. Nano-size vehicles are employed to deliver drugs to target the CSCs for cancer therapy. Polymeric nanoparticles have been considered as the most efficient vehicles for drug delivery due to their excellent pharmacokinetic properties. The CSCs specific antibodies or ligands can be conjugated onto the surface or interior of nanoparticles to successfully target and finally eliminate CSCs. In this review, we focus on the approaches of polymeric nanoparticles design for loading drug, and their potential application for CSCs targeting in cancer therapy.
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of TechnologyWuhan, China; Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Neurology, Affiliated Hospital of Guilin Medical University Guilin, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Li
authors.affiliation: Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-sen University), Ministry of EducationGuangzhou, China; Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen UniversityGuangzhou, China.
authors.forename: Jingxin
authors.initials: J
authors.lastname: Mo
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of TechnologyWuhan, China; Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan, China.
authors.forename: Honglian
authors.initials: H
authors.lastname: Dai
keywords: cancer stem cell; cancer therapy; drug-loaded; polymeric nanoparticle