title: Subthreshold linear modeling of dendritic trees: a computational approach.
abstract: The design of communication systems based on the transmission of information through neurons is envisioned as a key technology for the pervasive interconnection of future wearable and implantable devices. While previous literature has mainly focused on modeling propagation of electrochemical spikes carrying natural information through the nervous system, in recent work the authors of this paper proposed the so-called subthreshold electrical stimulation as a viable technique to propagate artificial information through neurons. This technique promises to limit the interference with natural communication processes, and it can be successfully approximated with linear models. In this paper, a novel model is proposed to account for the subthreshold stimuli propagation from the dendritic tree to the soma of a neuron. A computational approach is detailed to obtain this model for a given realistic 3D dendritic tree with an arbitrary morphology. Numerical results from the model are obtained over a stimulation signal bandwidth of 1KHz, and compared with the results of a simulation through the NEURON software.
authors.forename: Alireza
authors.initials: A
authors.lastname: Khodaei
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Pierobon
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D003712:Dendrites / Q000502:physiology*; D017097:Electric Impedance; D004558:Electric Stimulation; D016014:Linear Models; D008959:Models, Neurological; D009716:Numerical Analysis, Computer-Assisted