title: A New Potential Predictor of Coronary Artery Disease: The Ratio of Mitral Peak Filling Velocity to Mitral Annular Velocity in Early Diastole.
abstract: BACKGROUND The aim of this study was to explore the value of the ratio of mitral peak filling velocity (E) to mitral annular velocity (e') in early diastole as a predictor of coronary artery disease (CAD). MATERIAL AND METHODS The study population consisted of 83 consecutive patients (aged 38-77 years, 22 women and 61 men) who received coronary angiography. The E/e' ratio was estimated by echocardiographic examination. Statistical significance was determined by receiver operating characteristic (ROC) curve and multiple logistic regression analyses. RESULTS ROC curve analysis showed that the optimal E/e' ratio cut-off for predicting CAD was 8.153 with a specificity of 72.4% and sensitivity of 57.4%. The area under the ROC curve was 0.635 with a 95% confidence interval (CI) for normal distribution of 0.515-0.755 (p=0.043). Multivariate logistic regression analysis demonstrated that the E/e' ratio was closely associated with CAD (odds ratio [OR], 1.350; 95% CI, 1.087-1.676, p=0.007). CONCLUSIONS The E/e' ratio is a simple and practical predictor of CAD and may be an independent risk factor for CAD. Large-cohort and multi-center studies are required to confirm these observations.
authors.affiliation: Department of Echocardiography, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Echocardiography, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Echocardiography, First Affiliated Hospital, Xinjiang Medical University, Urumqi, China (mainland).
authors.forename: Zhisheng
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Echocardiography, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
authors.forename: Yuming
authors.initials: Y
authors.lastname: Mu
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003971:Diastole; D004452:Echocardiography; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology*; D015999:Multivariate Analysis; D012372:ROC Curve; D012307:Risk Factors; D018709:Statistics, Nonparametric