title: Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments.
abstract: In this study, one-step co-precipitation method was conveniently adapted to obtain novel nanomaterials based on Gum Arabic and magnetite. Two synthesis procedures were evaluated: one employing the solid biopolymer in the co-precipitation media; a second using an aqueous solution of the polysaccharide. An exhaustive characterization of both formulations was performed using several specific techniques. The obtained data confirmed the successful incorporation of the gum Arabic on the magnetic core. Values of hydrodynamic diameters, measured by dynamic light scattering, in aqueous dispersions were about 70-80nm, while sizes lower than 20nm were registered by TEM microscopy. Surface charge of gum Arabic coated magnetic nanoparticles was significantly different from the corresponding to raw materials (magnetite and GA). This fact confirmed the formation of hybrid nanosystems with novel and specific properties. The potential utility of these materials was tested regarding to magnetic hyperthermia therapy under radiofrequency fields. Magnetocalorimetric measurements were performed in a wide range of field amplitude and frequency. Specific absorption rate of 218W/gFe was determined at field frequency of 260kHz and amplitude of 52kA/m. These results demonstrate their viability to be applied in tumor ablation treatments. Using the linear response theory and restricting field parameters to the accepted biomedical window, maximum useful value of 74w/gFe is predicted at 417kHz and 12kA/m.
authors.affiliation: INQUISUR-CONICET, Dto. Química, Universidad Nacional del Sur, Bahía Blanca, Buenos Aires, Argentina. Electronic address: mfhorst@uns.edu.ar.
authors.forename: M Fernanda
authors.initials: MF
authors.lastname: Horst
authors.affiliation: Instituto de Física La Plata IFLP-CONICET, Departamento de Física, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina.
authors.forename: Diego F
authors.initials: DF
authors.lastname: Coral
authors.affiliation: Instituto de Física La Plata IFLP-CONICET, Departamento de Física, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina.
authors.forename: Marcela B
authors.initials: MB
authors.lastname: Fernández van Raap
authors.affiliation: INQUISUR-CONICET, Dto. Química, Universidad Nacional del Sur, Bahía Blanca, Buenos Aires, Argentina.
authors.forename: Mariana
authors.initials: M
authors.lastname: Alvarez
authors.affiliation: INQUISUR-CONICET, Dto. Química, Universidad Nacional del Sur, Bahía Blanca, Buenos Aires, Argentina.
authors.forename: Verónica
authors.initials: V
authors.lastname: Lassalle
mesh_terms: D000067493:Dynamic Light Scattering; D006170:Gum Arabic / Q000737:chemistry*; D006979:Hyperthermia, Induced; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D058185:Magnetite Nanoparticles; D006170:Gum Arabic
keywords: Gum Arabic; Hyperthermia; Magnetic nanoparticles; Magnetite