title: Copper-catalyzed regioselective 1,2-thioamidation of alkenes.
abstract: An efficient method for regioselective 1,2-thioamidation of terminal alkenes, catalyzed by copper in the presence of NFSI and thiols, has been disclosed. Under the reaction conditions, the amido radical was formed initially, followed by addition to the terminal carbon of alkenes and trapping of the resulting cuprate intermediate with thiols. Therefore, the regioselectivity was completely reversed compared to previously reported reactions which were initiated by sulfur-centred radicals or cations. When alkenes containing an amido N-H moiety were applied as substrates, intramolecular amido radical cyclization took place to afford sulfane substituted N-heterocycles.
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China. zhu_qiang@gibh.ac.cn.
authors.forename: Dengke
authors.initials: D
authors.lastname: Li
authors.forename: Tingting
authors.initials: T
authors.lastname: Mao
authors.forename: Jinbo
authors.initials: J
authors.lastname: Huang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu