title: Association of serum levels of anti-myeloperoxidase antibody with retinal photoreceptor ellipsoid zone disruption in diabetic retinopathy.
abstract: OBJECTIVE
  To study the association of serum levels of anti-myeloperoxidase (MPO) antibody with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy.
  
  
  METHODS
  Consecutive patients with type 2 DM [diabetes mellitus with no retinopathy (NODR; n=20); non-proliferative diabetic retinopathy (NPDR; n=18); proliferative diabetic retinopathy (PDR; n=16)] and healthy controls (n=20) between the ages of 40 and 65years were included. Disruption of EZ was graded by spectral domain optical coherence tomography as no disruption of EZ and disrupted EZ. The serum levels of anti-MPO antibody was analyzed using standard protocol. Association between the variables was evaluated using multiple regression analysis.
  
  
  RESULTS
  A significant difference was found between the serum levels of anti-MPO antibody in various study groups (p<0.001). A positive association was found between EZ disruption and levels of anti-MPO antibody [adjusted odd's ratio (AOR)=1.079, CI 1.010-1.124, p=0.04]. A significant positive correlation was found between logMAR visual acuity and grade of disruption (AOR=1.008, CI 1.006-5.688, p=0.04).
  
  
  CONCLUSIONS
  An increased serum anti-MPO antibody levels is associated with retinal photoreceptor EZ disruption and decreased visual acuity in diabetic retinopathy.
authors.affiliation: Retina service, Department of Ophthalmology, King George's Medical University, Lucknow, India.
authors.forename: Shivani
authors.initials: S
authors.lastname: Sinha
authors.affiliation: Retina service, Department of Ophthalmology, King George's Medical University, Lucknow, India. Electronic address: sandeepsaxena2020@yahoo.com.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Saxena
authors.affiliation: Department of Preventive and Social Medicine, King George's Medical University, Lucknow, India.
authors.forename: Senthamizh
authors.initials: S
authors.lastname: Prasad
authors.affiliation: Department of Biochemistry, King George's Medical University, Lucknow, India.
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Mahdi
authors.affiliation: Retina service, Department of Ophthalmology, King George's Medical University, Lucknow, India.
authors.forename: Shashi Kumar
authors.initials: SK
authors.lastname: Bhasker
authors.affiliation: Department of Rheumatology, King George's Medical University, Lucknow, India.
authors.forename: Siddharth
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovakia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Krasnik
authors.affiliation: 2nd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors.forename: Martin
authors.initials: M
authors.lastname: Caprnda
authors.affiliation: Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
authors.forename: Radka
authors.initials: R
authors.lastname: Opatrilova
authors.affiliation: Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. Electronic address: kruzliakpeter@gmail.com.
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
mesh_terms: D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003930:Diabetic Retinopathy / Q000097:blood / Q000000981:diagnostic imaging* / Q000276:immunology; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007194:India; D007518:Isoantibodies / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D018448:Models, Immunological; D009195:Peroxidase / Q000037:antagonists & inhibitors*; D020419:Photoreceptor Cells, Vertebrate / Q000276:immunology / Q000473:pathology*; D012044:Regression Analysis; D015203:Reproducibility of Results; D012160:Retina / Q000000981:diagnostic imaging* / Q000276:immunology; D012162:Retinal Degeneration / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging / Q000276:immunology; D062606:Tertiary Care Centers; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
chemical_list: D007518:Isoantibodies; D009195:Peroxidase
keywords: Anti-myeloperoxidase (anti-MPO) antibody; Decreased visual acuity; Non-proliferative diabetic retinopathy (NPDR); Proliferative diabetic retinopathy (PDR); Retinal photoreceptor ellipsoid zone disruption