title: A central role for a region in the middle.
abstract: A domain called the 'Conserved region in the middle' is responsible for target recognition in the TORC2 complex in fission yeast and the mTORC2 complex in mammals.
authors.affiliation: Biozentrum, University of Basel, Basel, Switzerland.
authors.forename: Edward
authors.identifier: 0000-0003-3932-9076
authors.initials: E
authors.lastname: Stuttfeld
authors.affiliation: Biozentrum, University of Basel, Basel, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Imseng
authors.affiliation: Biozentrum, University of Basel, Basel, Switzerland.
authors.forename: Timm
authors.identifier: 0000-0002-7459-1363
authors.initials: T
authors.lastname: Maier
mesh_terms: D000818:Animals; D002352:Carrier Proteins; D000076225:Mechanistic Target of Rapamycin Complex 2; D012568:Schizosaccharomyces; D029702:Schizosaccharomyces pombe Proteins; D013379:Substrate Specificity; D025801:Ubiquitin
chemical_list: D002352:Carrier Proteins; D029702:Schizosaccharomyces pombe Proteins; C000602849:Sin1 protein, S pombe; D025801:Ubiquitin; D000076225:Mechanistic Target of Rapamycin Complex 2
keywords: AKT; S. pombe; SIN1; TOR complex 2; TOR signaling; Target of Rapamycin; biochemistry; cell biology; human; substrate specificity