title: Isolation and structure elucidation of natural products of three soft corals and a sponge from the coast of Madagascar.
abstract: We investigated the three soft corals Sarcophyton stellatum, Capnella fungiformis and Lobophytum crassum and the sponge Pseudoceratina arabica, which have been collected at the coast of Madagascar. In addition to previously known marine natural products, S. stellatum provided the new (+)-enantiomer of the cembranoid (1E,3E,11E)-7,8-epoxycembra-1,3,11,15-tetraene (2). Capnella fungiformis afforded three new natural products, ethyl 5-[(1E,5Z)-2,6-dimethylocta-1,5,7-trienyl]furan-3-carboxylate (6), ethyl 5-[(1E,5E)-2,6-dimethylocta-1,5,7-trienyl]furan-3-carboxylate (7) and the diepoxyguaiane sesquiterpene oxyfungiformin (9a). The extracts of all three soft corals exhibited moderate activities against the malarial parasite Plasmodium falciparum. Extracts of the sponge Pseudoceratina arabica proved to be very active against a series of Gram-positive and Gram-negative bacteria.
authors.affiliation: Department Chemie, Technische Universität Dresden, Bergstr. 66, 01069 Dresden, Germany. hans-joachim.knoelker@tu-dresden.de.
authors.forename: Marie Pascaline
authors.initials: MP
authors.lastname: Rahelivao
authors.affiliation: Department Chemie, Technische Universität Dresden, Bergstr. 66, 01069 Dresden, Germany. hans-joachim.knoelker@tu-dresden.de.
authors.forename: Tilo
authors.identifier: http://orcid.org/0000-0003-3383-9518
authors.initials: T
authors.lastname: Lübken
authors.affiliation: Department Chemie, Technische Universität Dresden, Bergstr. 66, 01069 Dresden, Germany. hans-joachim.knoelker@tu-dresden.de.
authors.forename: Margit
authors.initials: M
authors.lastname: Gruner
authors.affiliation: A. M. Butlerov Chemistry Institute, Kazan Federal University, Kremlevskaya Str. 18, Kazan 420008, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Kataeva
authors.affiliation: Centre National de Recherche sur l'Environnement, BP 1739, Antananarivo 101, Madagascar.
authors.forename: Rahanira
authors.initials: R
authors.lastname: Ralambondrahety
authors.affiliation: Centre National de Recherche sur l'Environnement, BP 1739, Antananarivo 101, Madagascar.
authors.forename: Hanta
authors.initials: H
authors.lastname: Andriamanantoanina
authors.affiliation: CreativeQuantum GmbH, Wegedornstr. 32, 12524 Berlin, Germany.
authors.forename: Marek P
authors.initials: MP
authors.lastname: Checinski
authors.affiliation: Department Chemie, Technische Universität Dresden, Bergstr. 66, 01069 Dresden, Germany. hans-joachim.knoelker@tu-dresden.de.
authors.forename: Ingmar
authors.initials: I
authors.lastname: Bauer
authors.affiliation: Department Chemie, Technische Universität Dresden, Bergstr. 66, 01069 Dresden, Germany. hans-joachim.knoelker@tu-dresden.de.
authors.forename: Hans-Joachim
authors.identifier: http://orcid.org/0000-0002-9631-5239
authors.initials: HJ
authors.lastname: Knölker
mesh_terms: D000818:Animals; D037421:Anthozoa; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D008270:Madagascar; D008958:Models, Molecular; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D001688:Biological Products