title: Transcranial LED therapy on amyloid-β toxin 25-35 in the hippocampal region of rats.
abstract: Excessive Aβ deposition in the brain is associated with the formation of senile plaques, and their diffuse distribution is related to Alzheimer's disease. Thirty rats (EG) were irradiated with light-emitting diode (photobiomodulation (PBM)) in the frontal region of the skull after being inoculated with the Aβ toxin in the hippocampus; 30 rats were used as the control group (CG). The analysis was conducted at 7, 14, and 21 days after irradiation. We observed a decreased in Aβ deposits in treated animals compared with animals in the CG. The behavioral and motor assessment revealed that the EG group covered a larger ground distance and explored the open field than the CG group on days 14 and 21 (p < 0.05). The EG group was statistically significant in the spatial memory test compared to the CG group on day 14. The use of PBM significantly reduced the presence of Aβ plaques and improved spatial memory and behavioral and motor skills in treated animals on day 21.
authors.affiliation: Laboratory of Neuroanatomy and Neurophysiology for the Physiotherapy, Universidade Estadual do Centro-Oeste, Rua Simeão Camargo Varela de Sá, 03, Guarapuava, Paraná, Brazil, 85040-080.
authors.forename: Camila
authors.initials: C
authors.lastname: da Luz Eltchechem
authors.affiliation: School of Postural and Manual Therapy, Salgado Institute of Integral Health, Londrina, Paraná, Brazil, 86015-300.
authors.forename: Afonso Shiguemi Inoue
authors.initials: ASI
authors.lastname: Salgado
authors.affiliation: Center for Innovation, Technology and Education (CITÉ), São José dos Campos, São Paulo, Brazil, 12245-650.
authors.forename: Renato Amaro
authors.initials: RA
authors.lastname: Zângaro
authors.affiliation: Laboratory of Neuroanatomy and Neurophysiology for the Physiotherapy, Universidade Estadual do Centro-Oeste, Rua Simeão Camargo Varela de Sá, 03, Guarapuava, Paraná, Brazil, 85040-080.
authors.forename: Mário César
authors.initials: MC
authors.lastname: da Silva Pereira
authors.affiliation: Laboratory of Neuroanatomy and Neurophysiology for the Physiotherapy, Universidade Estadual do Centro-Oeste, Rua Simeão Camargo Varela de Sá, 03, Guarapuava, Paraná, Brazil, 85040-080. ikerppers@gmail.com.
authors.forename: Ivo Ilvan
authors.initials: II
authors.lastname: Kerppers
authors.affiliation: Laboratory of Biomedical Science for the Pharmacy, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil, 85040-080.
authors.forename: Luis Augusto
authors.initials: LA
authors.lastname: da Silva
authors.affiliation: School of Postural and Manual Therapy, Salgado Institute of Integral Health, Londrina, Paraná, Brazil, 86015-300.
authors.forename: Rodolfo Borges
authors.initials: RB
authors.lastname: Parreira
mesh_terms: D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D006624:Hippocampus / Q000528:radiation effects*; D053685:Laser Therapy; D028022:Low-Level Light Therapy; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000528:radiation effects; D010446:Peptide Fragments / Q000633:toxicity*; D017208:Rats, Wistar
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35)
keywords: Amyloid beta; Amyloid-β protein; Hippocampus; LED; Rats; Senile plaque; Spatial memory; Transcranial light-emitting diode