title: PCL-based thermo-gelling polymers for in vivo delivery of chemotherapeutics to tumors.
abstract: The synthesis of a multiblock poly(ether ester urethane)s comprising poly(ε-caprolactone), poly(ethylene glycol), and poly(propylene glycol) segments is described. We found that this polymer possessed a critical thermo-gelation concentration of 4wt%. Molecular characterization of the polymer was performed in terms of molecular weight determination, chemical composition elucidation and functional group determination using GPC, NMR, and FTIR. We carried out in vitro paclitaxel and doxorubicin release studies and demonstrated that sustained therapeutic release of about 2weeks can be obtained with this system. A nude mice model of tumor was developed and intratumoral injection of therapeutic-loaded thermo-gel demonstrated that PTX-loaded thermo-gel effectively inhibited the growth of tumors.
authors.affiliation: The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
authors.forename: Chaohui
authors.initials: C
authors.lastname: Zheng
authors.affiliation: The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Gao
authors.affiliation: The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China; Fujian Province Key Laboratory for the Development of Bioactive Materials from Marine Algae, College of Chemical Engineering & Materials Science, Quanzhou Normal University, Quanzhou, China. Electronic address: yangdp@qztc.edu.cn.
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Yang
authors.affiliation: Fujian Province Key Laboratory for the Development of Bioactive Materials from Marine Algae, College of Chemical Engineering & Materials Science, Quanzhou Normal University, Quanzhou, China.
authors.forename: Minghuan
authors.initials: M
authors.lastname: Liu
authors.affiliation: Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China. Electronic address: wuyl@xmu.edu.cn.
authors.forename: Yun-Long
authors.initials: YL
authors.lastname: Wu
authors.affiliation: Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore. Electronic address: mselohx@nus.edu.sg.
authors.forename: Xian Jun
authors.initials: XJ
authors.lastname: Loh
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D002850:Chromatography, Gel; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009369:Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011409:Propylene Glycols / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005782:Gels; D011091:Polyesters; D011108:Polymers; D011409:Propylene Glycols; C016240:polycaprolactone; C012504:polypropylene glycol; D011092:Polyethylene Glycols; D004317:Doxorubicin; D017239:Paclitaxel