title: Thoracic Aortic Aneurysm from Chronic Antiestrogen Therapy.
abstract: Aortic aneurysms are a common but often undetected pathology prevalent in the population. They are often detected as incidental findings on imaging studies performed for unrelated pathologies. Estrogens have been shown to exert a protective influence on aortic tissue. Pharmacological agents blocking the actions of estrogens may thus be implicated in causing aortic pathologies. We present the case of an elderly woman with breast carcinoma treated for 18 years with antiestrogen therapy who subsequently developed acute thoracic aortic deterioration (enlargement and wall disruption).
authors.affiliation: Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Rishi
authors.initials: R
authors.lastname: Tripathi
authors.affiliation: Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Sainathan
authors.affiliation: Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, Connecticut; Department of Surgical Diseases, Kazan State Medical University, Kazan, Russia.
authors.forename: Bulat A
authors.initials: BA
authors.lastname: Ziganshin
authors.affiliation: Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: John A
authors.initials: JA
authors.lastname: Elefteriades
keywords: aortic aneurysm; breast carcinoma; estrogen