title: Association between the Matrix Metalloproteinase-9 rs3918242 Polymorphism and Ischemic Stroke Susceptibility: A Meta-Analysis.
abstract: BACKGROUND
  In recent years, dozens of case-control studies showed that matrix metalloproteinase (MMP)-9 rs3918242 variants were associated with ischemic stroke (IS) susceptibility. However, the conclusions of case-control studies that evaluated the relationship between MMP-9 rs3918242 variants and the risk of IS were still equivocal. Herein, we conducted a comprehensive meta-analysis to investigate the association between MMP-9 rs3918242 variants and the risk of IS.
  
  
  METHODS
  We searched 5 databases (PubMed, EMBASE, Google Scholar, Web of Science, and Chinese Biomedical Literature Database) to identify the eligible studies up to October of 2016. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association of MMP-9 rs3918242 variants with IS susceptibility under the allelic model (T versus C) and the dominant model (TT + CT versus CC).
  
  
  RESULTS
  A total of 14 studies with 3233 cases and 3123 controls were included in this meta-analysis. Our meta-analysis indicated that MMP-9 rs3918242 variants were associated with significantly increased risk of IS in overall populations (T versus C: OR = 1.43, 95% CI = 1.20-1.71, P < .001; TT + CT versus CC: OR = 1.39, 95% CI = 1.16-1.67, P < .001). Subgroup analysis based on ethnicity (Chinese and Caucasian) suggested that MMP-9 rs3918242 variants contributed to increase the risk of IS in Chinese population; However, no association was detected between MMP-9 rs3918242 variants and the risk of IS in Caucasian population.
  
  
  CONCLUSIONS
  Therefore, our meta-analysis suggested that MMP-9 rs3918242 variants (T allele, TT and CT genotypes) contributed to significantly increase the risk of IS in the Chinese population.
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.affiliation: Department of Gerontology, Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Wen-Shuai
authors.initials: WS
authors.lastname: Deng
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: 123022647@qq.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
mesh_terms: D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000175:diagnosis / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*
chemical_list: C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
keywords: MMP-9; ischemic stroke; meta-analysis; polymorphism