title: Family history of cancer and head and neck cancer survival.
abstract: Patients with a family history of cancer may be genetically predisposed to carcinogenesis. This could affect risk of recurrence, second primary tumors, and overall outcomes after treatment of a primary cancer. We evaluated the association between family history of cancer and disease-specific survival in a cohort of patients with primary head and neck squamous carcinoma (HNSCC).
  
  
  
  Six hundred and forty-three incident HNSCC patients recruited through the University of Michigan Specialized Program of Research Excellence were followed for up to 5 years for survival. Participants were interviewed about personal and family cancer history, demographic information, and behavioral habits.
  
  
  
  Cox proportional hazards models were used to estimate the association between family history of cancer in a first-degree relative and disease-specific survival.
  
  
  
  After multivariable adjustment, we found a nonsignificant inverse association between family history and HNSCC mortality (hazard ratio [HR] = 0.88, 95% confidence interval [CI] 0.57-1.35). This association was stronger and statistically significant among patients who currently both drank alcohol and smoked cigarettes at diagnosis (HR = 0.46, 95% CI = 0.22-0.97); no association was observed among participants who did not both drink and smoke at the time of diagnosis (HR = 1.14, 95% CI = 0.68-1.91; p-interaction = 0.046).
  
  
  
  Results from this study suggest that having a family history of cancer may be associated with improved disease-specific survival in patients who use tobacco and alcohol. Additional large studies, particularly in populations including nonwhites and women, are needed to confirm or refute the association and to elucidate the genetic factors that may underlie this potential association.
  
  
  
  2b. Laryngoscope, 127:1816-1820, 2017.
authors.affiliation: Department of Epidemiology.
authors.forename: Kayla R
authors.initials: KR
authors.lastname: Getz
authors.affiliation: Department of Environmental Health Sciences.|Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, U.S.A.
authors.forename: Laura S
authors.initials: LS
authors.lastname: Rozek
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, U.S.A.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Peterson
authors.affiliation: Department of Biostatistics, University of Michigan School of Public Health.
authors.forename: Emily L
authors.initials: EL
authors.lastname: Bellile
authors.affiliation: Department of Biostatistics, University of Michigan School of Public Health.
authors.forename: Jeremy M G
authors.initials: JMG
authors.lastname: Taylor
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, U.S.A.
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Wolf
authors.affiliation: Department of Epidemiology.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Mondul
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D015996:Survival Rate
keywords: Head and neck cancer; epidemiology; family history; mortality; survival