title: Extremely refractory Kawasaki disease with disseminated intravascular coagulation.
abstract: Disseminated intravascular coagulation is a rare complication of Kawasaki disease and appears in <0.1% of Kawasaki disease patients. We report a case of refractory Kawasaki disease complicated with disseminated intravascular coagulation and giant coronary aneurysm. A 5-month-old boy presented with Kawasaki disease with coagulopathy. Although the coagulopathy improved after fresh-frozen plasma and antithrombin-III administration, the fever persisted despite two rounds of intravenous immunoglobulin, along with intravenous methylprednisolone pulse therapy and infliximab administration. Despite all efforts to treatment, the patient had giant coronary aneurysms and died suddenly.
authors.affiliation: Department of Pediatrics,Chosun University School of Medicine,Gwangju,Republic of Korea.
authors.forename: Young Kwon
authors.initials: YK
authors.lastname: Koh
authors.affiliation: Department of Pediatrics,Chosun University School of Medicine,Gwangju,Republic of Korea.
authors.forename: Jae Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Pediatrics,Chosun University School of Medicine,Gwangju,Republic of Korea.
authors.forename: Yeong Bong
authors.initials: YB
authors.lastname: Park
mesh_terms: D003323:Coronary Aneurysm / Q000000981:diagnostic imaging*; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy*; D004452:Echocardiography; D017809:Fatal Outcome; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D000069285:Infliximab / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*
chemical_list: D016756:Immunoglobulins, Intravenous; D000069285:Infliximab; D008775:Methylprednisolone
keywords: Kawasaki disease; coronary aneurysm; disseminated intravascular coagulation