title: Toxic effects on bioaccumulation and hematological parameters of juvenile rockfish Sebastes schlegelii exposed to dietary lead (Pb) and ascorbic acid.
abstract: Juvenile rockfish, Sebastes schlegelii (mean length 11.3 ± 1.2 cm, and mean weight 32.5 ± 4.1 g) were exposed for four weeks to dietary lead (Pb2+) at 0, 120, and 240 mg/L and ascorbic acid (AsA) at 100, 200, and 400 mg/L. The exposure concentrations and duration of significant Pb-induced accumulations in specific tissues of S. schlegelii were assessed. High levels of ascorbic acid significantly attenuated accumulations following exposure to dietary Pb. Dietary Pb exposure caused a significant increase in blood Pb concentrations, whereas red blood cell (RBC) count, hematocrit, and hemoglobin were significantly decreased. Notable changes were also observed in plasma calcium, magnesium, glucose, cholesterol, glutamic oxaloacetic transaminase (GOT), and glutamic pyruvate transaminase (GPT). The growth performance of S. schlegelii was significantly decreased. High doses AsA supplemention were effective in attenuating the changes brought about by dietary Pb exposure.
authors.affiliation: West Sea Fisheries Research Institute, National Institute of Fisheries Science, Incheon 22383, South Korea.
authors.forename: Jun-Hwan
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Aquatic Life Medicine, Pukyong National University, Busan 48513, South Korea. Electronic address: jckang@pknu.ac.kr.
authors.forename: Ju-Chan
authors.initials: JC
authors.lastname: Kang
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001492:Bass / Q000097:blood* / Q000254:growth & development; D001774:Blood Chemical Analysis / Q000379:methods; D004032:Diet; D004781:Environmental Exposure / Q000009:adverse effects*; D004906:Erythrocyte Count; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007854:Lead / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D006454:Hemoglobins; D014874:Water Pollutants, Chemical; D007854:Lead; D001205:Ascorbic Acid
keywords: Ascorbic acid; Bioaccumulation; Hematological parameters; Pb; Rockfish