title: Chordae Tendineae Rupture in the United States: Trends of Outcomes, Costs and Surgical Interventions.
abstract: To describe national trends in the incidence and outcomes of patients with chordae tendineae rupture (CTR).
  
  
  
  Patients who were diagnosed with CTR between 2000 and 2012 were identified in National (Nationwide) Inpatient Sample (NIS) registry. CTR was defined using validated International Classification of Diseases, 9th Edition, Clinical Modification diagnosis (ICD9-CM) codes. Results: A total of 37,287 (14,833 mitral valve repair, 7780 mitral valve replacement) CTR cases were identified. Overall, in-hospital mortality in CTR decreased by 3% from 2000 to 2012 (P < 0.001). From 2000 to 2012, the rate of mitral valve repair increased from 27.2% to 46.4%, (P < 0.001) with a concurrent decrease in the rate of mitral valve replacement (from 27.8 to 17.7%, P < 0.001). After multivariate adjustment, patient age (OR = 1.04, 95% CI 1.03-1.06, P < 0.001), congestive heart failure (CHF) (OR = 2.08, 95% CI 1.19-3.64, P = 0.01), myocardial infarction (MI) (OR = 3.58, 95% CI 2.10-6.11, P < 0.001), Deyo/Charlson comorbidity index (OR = 1.23, 95% CI 1.07-1.41, P < 0.003) and use of the intra aortic balloon pump (IABP) (OR = 4.81 95% CI 2.71-8.55, P < 0.001) were found to be independently associated with greater odds of mortality in these patients. Additionally, mitral valve replacement was significantly associated with higher costs of hospitalization (coefficient 15693, 95% CI 12638-18749, P < 0.001)Conclusion: Mitral valve repair is associated with reduced inpatient mortality and costs compared with mitral valve replacement. A substantial increase in the percentage of cases undergoing mitral valve repair with a concurrent decrease in cases undergoing mitral valve replacement were observed. Increasing age and comorbidity index, history of CHF and MI, and use of IABP were identified as factors that could increase the risk of mortality in patients with CTR.
authors.affiliation: Department of Medicine, Rutgers New Jersey Medical School, The State University of New Jersey, Newark, New Jersey, USA.
authors.forename: Elena V
authors.initials: EV
authors.lastname: Dolmatova
authors.affiliation: Department of Medicine, Rutgers New Jersey Medical School, The State University of New Jersey, Newark, New Jersey, USA.
authors.forename: Kasra
authors.initials: K
authors.lastname: Moazzami
authors.affiliation: Department of Medicine, Rutgers New Jersey Medical School, The State University of New Jersey, Newark, New Jersey, USA.|Division of Cardiology, Department of Medicine, Rutgers New Jersey Medical School, The State University of New Jersey, Newark, New Jersey, USA.
authors.forename: James
authors.initials: J
authors.lastname: Maher
authors.affiliation: Department of Medicine, Rutgers New Jersey Medical School, The State University of New Jersey, Newark, New Jersey, USA.|Division of Cardiology, Department of Medicine, Rutgers New Jersey Medical School, The State University of New Jersey, Newark, New Jersey, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Klapholz
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, Rutgers New Jersey Medical School, The State University of New Jersey, Newark, New Jersey, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Sambol
authors.affiliation: Department of Medicine, Rutgers New Jersey Medical School, The State University of New Jersey, Newark, New Jersey, USA.|Division of Cardiology, Department of Medicine, Rutgers New Jersey Medical School, The State University of New Jersey, Newark, New Jersey, USA.
authors.forename: Alfonso H
authors.initials: AH
authors.lastname: Waller
mesh_terms: D000368:Aged; D002815:Chordae Tendineae; D003362:Cost-Benefit Analysis; D017548:Echocardiography, Transesophageal; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation / Q000191:economics* / Q000379:methods; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D012189:Retrospective Studies; D012422:Rupture, Spontaneous; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology