title: The Essential Role of Bond Energetics in C-H Activation/Functionalization.
abstract: The most fundamental concepts in chemistry are structure, energetics, reactivity and their inter-relationships, which are indispensable for promoting chemistry into a rational science. In this regard, bond energy, the intrinsic determinant directly related to structure and reactivity, should be most essential in serving as a quantitative basis for the design and understanding of organic transformations. Although C-H activation/functionalization have drawn tremendous research attention and flourished during the past decades, understanding the governing rules of bond energetics in these processes is still fragmentary and seems applicable only to limited cases, such as metal-oxo-mediated hydrogen atom abstraction. Despite the complexity of C-H activation/functionalization and the difficulties in measuring bond energies both for the substrates and intermediates, this is definitely a very important issue that should be more generally contemplated. To this end, this review is rooted in the energetic aspects of C-H activation/functionalization, which were previously rarely discussed in detail. Starting with a concise but necessary introduction of various classical methods for measuring heterolytic and homolytic energies for C-H bonds, the present review provides examples that applied the concept and values of C-H bond energy in rationalizing the observations associated with reactivity and/or selectivity in C-H activation/functionalization.
authors.affiliation: State Key Laboratory of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University , Tianjin, 300071, China.
authors.forename: Xiao-Song
authors.identifier: http://orcid.org/0000-0003-4541-8702
authors.initials: XS
authors.lastname: Xue
authors.affiliation: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University , Beijing, 100084, China.
authors.forename: Pengju
authors.initials: P
authors.lastname: Ji
authors.affiliation: State Key Laboratory of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University , Tianjin, 300071, China.
authors.forename: Biying
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University , Beijing, 100084, China.|State Key Laboratory of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University , Tianjin, 300071, China.
authors.forename: Jin-Pei
authors.identifier: http://orcid.org/0000-0001-8822-1577
authors.initials: JP
authors.lastname: Cheng