title: Relationship of Serum Klotho Level With ACE Gene Polymorphism in Stable Kidney Allograft Recipients.
abstract: BACKGROUND
  The kidney is the main source of serum Klotho production. Immunosuppressive agents could affect the kidney in this regard. The effect of the ACE gene polymorphism on Klotho production is a less studied area. This study aimed to assess serum Klotho and ACE gene in a group of stable kidney transplant recipients.
  
  
  METHODS
  In a cross-sectional study, 30 kidney transplant recipients with stable allograft function and 27 healthy young individuals were assessed for their serum Klotho levels. The ACE gene polymorphisms were studied in both groups.
  
  
  RESULTS
  Klotho level was higher in kidney transplant recipients than the controls, but the difference was not significant (2.76 ± 2.41 ng/mL versus 2.01 ± 1.41 ng/mL, respectively). In both groups, serum Klotho level was higher in those with the I>I polymorphism, the men, those with higher glomerular filtration rate, and younger individuals, but the differences did not reach a significant level. Higher body mass index was significantly associated with lower serum Klotho level in both groups.
  
  
  CONCLUSIONS
  Klotho level after kidney transplantation meets the range in healthy individuals, and it is not affected by the ACE gene polymorphism.
authors.forename: Maryam
authors.initials: M
authors.lastname: Zaare Nahandi
authors.affiliation: Chronic Kidney Disease Research Center, Sina Educational Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. ardalan34@yahoo.com.
authors.forename: Mohamad Reza
authors.initials: MR
authors.lastname: Ardalan
authors.forename: Ali
authors.initials: A
authors.lastname: Banagozar Mohamadi
authors.forename: Amir
authors.initials: A
authors.lastname: Ghorbani Haghjo
authors.forename: Morteza
authors.initials: M
authors.lastname: Jabbarpor Bonyadi
authors.forename: Tahere
authors.initials: T
authors.lastname: Mohamadian
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D005966:Glucuronidase / Q000097:blood*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007492:Iran; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation; D000090265:Klotho Proteins; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D005966:Glucuronidase; D000090265:Klotho Proteins; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A