title: Two cases of perivascular epithelioid cell tumor of the uterus: clinical, radiological and pathological diagnostic challenge.
abstract: BACKGROUND
  Perivascular epithelioid cell tumor (PEComa) is a rare subtype of mesenchymal origin tumor composed of epithelioid cells which exhibits immunohistochemical co-expressions of melanocytic markers and smooth muscle markers.
  
  
  METHODS
  In the first case, malignant uterine PEComa with vaginal and multiple lung metastasis was misdiagnosed preoperatively as uterine leiomyosarcoma despite a preoperative punch biopsy and immunohistochemical analysis of the metastatic vaginal mass. In the second case, synchronous uterine PEComa showing benign histology with lymph node involvement was incidentally detected after a staging operation for ovarian cancer. Definitive diagnosis of uterine PEComa was achieved only after hysterectomy despite preoperative assessment with pelvic magnetic resonance imaging and punch biopsy of metastatic lesion.
  
  
  CONCLUSIONS
  The authors report two rare cases of uterine PEComa diagnosed postoperatively based on the morphologic and immunohistochemical features.
authors.affiliation: Department of Obstetrics and Gynecology, Pusan National University School of Medicine, 179, Gudeok-Ro, Seo-Gu, Busan, 49241, South Korea.|Biomedical Research Institute and Pusan Cancer Center, Pusan National University Hospital, 179, Gudeok-Ro, Seo-Gu, Busan, 49241, South Korea.
authors.forename: Byung Su
authors.initials: BS
authors.lastname: Kwon
authors.affiliation: Department of Obstetrics and Gynecology, Pusan National University School of Medicine, 179, Gudeok-Ro, Seo-Gu, Busan, 49241, South Korea.|Biomedical Research Institute and Pusan Cancer Center, Pusan National University Hospital, 179, Gudeok-Ro, Seo-Gu, Busan, 49241, South Korea.
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Suh
authors.affiliation: Department of Radiology, Pusan National University School of Medicine, Busan, 49241, South Korea.
authors.forename: Nam Kyung
authors.initials: NK
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Pusan National University School of Medicine, 179, Gudeok-Ro, Seo-Gu, Busan, 49241, South Korea.
authors.forename: Yong Jung
authors.initials: YJ
authors.lastname: Song
authors.affiliation: Department of Pathology, Pusan National University School of Medicine, Busan, 49241, South Korea.
authors.forename: Kyung Un
authors.initials: KU
authors.lastname: Choi
authors.affiliation: Department of Obstetrics and Gynecology, Pusan National University School of Medicine, 179, Gudeok-Ro, Seo-Gu, Busan, 49241, South Korea. ghkim@pusan.ac.kr.|Biomedical Research Institute and Pusan Cancer Center, Pusan National University Hospital, 179, Gudeok-Ro, Seo-Gu, Busan, 49241, South Korea. ghkim@pusan.ac.kr.
authors.forename: Ki Hyung
authors.initials: KH
authors.lastname: Kim
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D054973:Perivascular Epithelioid Cell Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology
keywords: Immunohistochemistry; Morphology; Perivascular epithelioid cell tumor (PEComa)