title: Polishing the tarnished silver bullet: the quest for new antibiotics.
abstract: We are facing a potential catastrophe of untreatable bacterial infections, driven by the inexorable rise of extensively drug-resistant bacteria, coupled with a market failure of pharmaceutical and biotech companies to deliver new therapeutic options. While global recognition of the problem is finally apparent, solutions are still a long way from being implemented. In addition to drug stewardship programmes and better diagnostics, new antibiotics are desperately needed. The question remains as to how to achieve this goal. This review will examine the different strategies being applied to discover new antibiotics.
authors.affiliation: Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane 4072, Australia m.blaskovich@uq.edu.au.
authors.forename: Mark A T
authors.initials: MA
authors.lastname: Blaskovich
authors.affiliation: Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane 4072, Australia.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Butler
authors.affiliation: Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane 4072, Australia.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Cooper
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D063045:Crowdsourcing; D055808:Drug Discovery; D004352:Drug Resistance, Microbial / Q000187:drug effects*; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents
keywords: Gram negative bacteria; Gram positive bacteria; antibiotic resistance; antibiotics; bacterial infections; drug discovery and design