title: Cutaneous dermal non-neural granular cell tumor is a granular cell dermal root sheath fibroma.
abstract: Dermal non-neural granular cell tumor (NNGCT) was first described in 1991 as an S100-negative polypoid non-melanocytic tumor. Although originally introduced in the literature as a primary cutaneous tumor, it was later emphasized that such qualification could not be held until the line of differentiation was clarified. It was also demonstrated that not all cases were polypoid. In the current study we try to further characterize this entity by presenting 5 cases of NNGCT. As expected, not all of them were polypoid. The ages of the patients varied from 10 to 43 (mean age 22). They all were composed of S100-negative granular cells with variable atypia and mitotic figures. None of them recurred in follow-up of up to 12 years (mean 8.2 years). We found evidence of folliculocentricity in 4 cases (in 1 case, this feature could not be investigated because the biopsy was a small shave specimen), that is, tumors were always surrounding, embedding, or following a hair follicle. In some occasions, such features were better demonstrated by immunohistochemistry against the arrector pili muscle. Our cases showed intense immunoexpression of CD10 and CD68. We conclude that NNGCT is morphologically related to the hair follicle and we believe that it is a granular cell dermal root sheath fibroma.
authors.affiliation: Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain.|Biomedical Investigation Institute of A Coruña, CellCOM-ST Group, A Coruña, Spain.|Department of Cellular Pathology, Hospital de la Reina, Ponferrada, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Fernandez-Flores
authors.affiliation: Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, California.
authors.forename: David S
authors.initials: DS
authors.lastname: Cassarino
authors.affiliation: Department of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain.|Universidad Complutense, Medical School (UCM), Instituto i + 12, Madrid, Spain.
authors.forename: Erica
authors.initials: E
authors.lastname: Riveiro-Falkenbach
authors.affiliation: Department of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain.|Universidad Complutense, Medical School (UCM), Instituto i + 12, Madrid, Spain.|Department of Histopathology, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Rodriguez-Peralto
authors.affiliation: Hospital Universitari General de Catalunya-Grupo Quirón Salud, Barcelona, Spain.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Fernandez-Figueras
authors.affiliation: Biomedical Research Institute INCLIVA, Valencia, Spain.|University of Valencia, Medical School, Valencia, Spain.|Hospital Clinico Universitario de Valencia, Valencia, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Monteagudo
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D002648:Child; D005260:Female; D005350:Fibroma / Q000378:metabolism / Q000473:pathology; D018859:Hair Follicle / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism; D015260:Neprilysin / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009363:Neoplasm Proteins; D015260:Neprilysin; C067980:CD68 antigen, human; D000097382:CD68 Molecule
keywords: dermal non-neural granular cell tumor; dermal root sheath; polypoid granular cell tumor