title: Nitinol Self-Expanding Stents for the Superficial Femoral Artery.
abstract: The superficial femoral artery is a complex artery subject to a unique set of biomechanical loading conditions in its course through the leg. Plain balloon angioplasty and balloon-expandable stents had unacceptably high rates of restenosis, necessitating target vessel revascularization. Nitinol alloy is well suited to provide the strength and flexibility needed of stents to withstand the external forces posed by the environment of the superficial femoral artery. Advances in stent technology with the addition of a slow-releasing antiproliferative agent and changes in scaffold design have shown promise in reducing the rates of stent fracture and in-stent restenosis.
authors.affiliation: Cardiovascular Medicine Division, Perelman Center, Hospital of the University of Pennsylvania, South Tower, 11th Floor, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA; Penn Cardiovascular Quality, Outcomes, and Evaluative Research Center, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Ashwin
authors.initials: A
authors.lastname: Nathan
authors.affiliation: Cardiovascular Medicine Division, Perelman Center, Hospital of the University of Pennsylvania, South Tower, 11th Floor, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA; Penn Cardiovascular Quality, Outcomes, and Evaluative Research Center, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Taisei
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: Cardiovascular Medicine Division, Perelman Center, Hospital of the University of Pennsylvania, South Tower, 11th Floor, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA; Penn Cardiovascular Quality, Outcomes, and Evaluative Research Center, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: Jay.Giri@uphs.upenn.edu.
authors.forename: Jay
authors.initials: J
authors.lastname: Giri
mesh_terms: D000497:Alloys; D005263:Femoral Artery / Q000601:surgery*; D006801:Humans; D058729:Peripheral Arterial Disease / Q000601:surgery*; D011474:Prosthesis Design; D000069322:Self Expandable Metallic Stents; D014656:Vascular Surgical Procedures / Q000379:methods*
chemical_list: D000497:Alloys; C013616:nitinol
keywords: Nitinol; Peripheral arterial disease; Self-expanding stents; Superficial femoral artery