title: Testing the Amyloid Hypothesis with a Humanized AD Mouse Model.
abstract: In this issue of Neuron, Espuny-Camacho et al. (2017) generate a humanized Alzheimer's disease (AD) model that reveals species-specific vulnerability of human neurons to AD pathology. This model provides key insights for disease mechanism and therapeutic discovery for AD.
authors.affiliation: Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Michelle K
authors.initials: MK
authors.lastname: Cahill
authors.affiliation: Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA; Division of Neuropathology Research, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94143, USA; Pathology Service 113B, Veterans Administrations Medical Center, San Francisco, CA 94121, USA. Electronic address: eric.huang2@ucsf.edu.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Huang
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D000682:Amyloid / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D016875:tau Proteins
keywords: Alzheimer’s disease; amyloid plaque; induced pluripotent stem cells (iPSCs); mouse model; neurofibrillary tangle; transplantation