title: MS/MS similarity networking accelerated target profiling of triterpene saponins in Eleutherococcus senticosus leaves.
abstract: The targeted mass information of compounds accelerated their discovery in a large volume of untargeted MS data. An MS/MS similarity networking is advanced in clustering the structural analogues, which benefits the collection of mass information of similar compounds. The triterpene saponins extracted from Eleutherococcus senticosus leaves (ESL), a kind of functional tea, have shown promise in the relief of Alzheimer's disease. In this work, a target-precursor list (TPL) generated using MS/MS similarity networking was employed to rapidly trace 106 triterpene saponins from the aqueous extracts of ESL, of which 49 were tentatively identified as potentially new triterpene saponins. Moreover, a compound database of triterpene saponins was established and successfully applied to uncover their distribution features in ESL samples collected from different areas.
authors.affiliation: Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Ge
authors.affiliation: Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki 305-0843, Japan.
authors.forename: Kayo
authors.initials: K
authors.lastname: Yoshimatsu
authors.affiliation: Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan. Electronic address: katsukok@inm.u-toyama.ac.jp.
authors.forename: Katsuko
authors.initials: K
authors.lastname: Komatsu
mesh_terms: D028001:Eleutherococcus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D012503:Saponins / Q000737:chemistry*; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes
keywords: Acanthopanaxoside A (PubChem CID: 11995583); Ciwujianoside B (PubChem CID: 102004424); Ciwujianoside C2 (PubChem CID: 44559145); Ciwujianoside C3 (PubChem CID: 21626481); Ciwujianoside D2 (PubChem CID: 44559147); Eleutherococcus senticosus; Eleutheroside M (PubChem CID: 56842417); MS/MS similarity networking; Target-precursor list; Triterpene saponins