title: Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity.
abstract: A convenient synthesis of substituted spiroindenoquinoxalines at mild and green conditions was developed. Multicomponent reaction of substituted phenylene diamines, ninhydrin, malononitrile and N,N'-substituted-2-nitroethene-1,1-diamines produced the target compounds. Twelve new spiroindenoquinoxalines were obtained, and their ability in inhibition of acetyl and butyrylcholinesterases were investigated both in vitro and in silico. All compounds showed moderate level activity against both acetyl and butyrylcholinesterases.
authors.affiliation: Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran.
authors.forename: Ammar
authors.initials: A
authors.lastname: Maryamabadi
authors.affiliation: Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran. Electronic address: a_hasaninejad@yahoo.com.
authors.forename: Alireza
authors.initials: A
authors.lastname: Hasaninejad
authors.affiliation: Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran.
authors.forename: Najmeh
authors.initials: N
authors.lastname: Nowrouzi
authors.affiliation: Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Mohebbi
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects; D002091:Butyrylcholinesterase / Q000187:drug effects; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D066244:Proton Magnetic Resonance Spectroscopy; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D002800:Cholinesterase Inhibitors; D011810:Quinoxalines; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase
keywords: Acetylcholinesterase inhibition; Butyrylcholinesterase inhibition; Catalyst-free; Indenoquinoxaline; Multi-component reactions