title: Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology.
abstract: Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent on a sustained energy supply and adequate calcium buffering, both of which are provided by mitochondria. Moreover, in vascular smooth muscle cells, mitochondrial metabolism modulates cell growth and proliferation, whereas cytosolic calcium levels regulate the arterial vascular tone. Physical and functional communication between mitochondria and sarco/endoplasmic reticulum and balanced mitochondrial dynamics seem to have a critical role for optimal calcium transfer to mitochondria, which is crucial in calcium homeostasis and mitochondrial metabolism in both types of muscle cells. Moreover, mitochondrial dysfunction has been associated with myocardial damage and dysregulation of vascular smooth muscle proliferation. Therefore, sarco/endoplasmic reticulum-mitochondria coupling and mitochondrial dynamics are now viewed as relevant factors in the pathogenesis of cardiac and vascular diseases, including coronary artery disease, heart failure, and pulmonary arterial hypertension. In this Review, we summarize the evidence related to the role of sarco/endoplasmic reticulum-mitochondria communication in cardiac and vascular muscle physiology, with a focus on how perturbations contribute to the pathogenesis of cardiovascular disorders.
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Quimicas y Farmaceuticas &Facultad de Medicina, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile.
authors.forename: Camila
authors.initials: C
authors.lastname: Lopez-Crisosto
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Quimicas y Farmaceuticas &Facultad de Medicina, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile.
authors.forename: Christian
authors.initials: C
authors.lastname: Pennanen
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Quimicas y Farmaceuticas &Facultad de Medicina, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile.
authors.forename: Cesar
authors.initials: C
authors.lastname: Vasquez-Trincado
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Quimicas y Farmaceuticas &Facultad de Medicina, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile.
authors.forename: Pablo E
authors.initials: PE
authors.lastname: Morales
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Quimicas y Farmaceuticas &Facultad de Medicina, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile.|Instituto de Nutricion y Tecnologia de los Alimentos (INTA), Universidad de Chile, Avenida El Líbano 5524, Santiago 7830490, Chile.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bravo-Sagua
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Quimicas y Farmaceuticas &Facultad de Medicina, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile.|Centro de Estudios Moleculares de la Celula (CEMC), Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.
authors.forename: Andrew F G
authors.initials: AFG
authors.lastname: Quest
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Quimicas y Farmaceuticas &Facultad de Medicina, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile.
authors.forename: Mario
authors.initials: M
authors.lastname: Chiong
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Quimicas y Farmaceuticas &Facultad de Medicina, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile.|Centro de Estudios Moleculares de la Celula (CEMC), Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.|Department of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75235, USA.
authors.forename: Sergio
authors.initials: S
authors.lastname: Lavandero
mesh_terms: D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008929:Mitochondria, Heart / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D032383:Myocytes, Cardiac / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*