title: Cytotoxicity of flavonoids and isoflavonoids from Crotalaria bracteata.
abstract: A new flavonoid, crotakanda (1), and seven known compounds including a flavonoid, four isoflavonoids, a pterocarpan and a cinnamaldehyde were isolated from the stems and roots of Crotalaria bracteata. Their structures were elucidated by a combination of spectroscopic methods. Compound 2 showed cytotoxicity against MCF-7 with an IC50value of 79.90 μM whereas 2 and 4 exhibited cytotoxicity against the NCI-H187 cell line with IC50values of 71.57 and 95.47 μM, respectively.
authors.affiliation: a Natural Products Research Unit, Faculty of Science, Department of Chemistry, Center of Excellence for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Sukanda
authors.initials: S
authors.lastname: Sudanich
authors.affiliation: b Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Toxicology , Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Suppachai
authors.initials: S
authors.lastname: Tiyaworanant
authors.affiliation: a Natural Products Research Unit, Faculty of Science, Department of Chemistry, Center of Excellence for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Chavi
authors.initials: C
authors.lastname: Yenjai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D029864:Crotalaria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000737:chemistry* / Q000494:pharmacology; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D036343:Pterocarpans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D007529:Isoflavones; D036343:Pterocarpans
keywords: Crotalaria bracteata; crotakanda; flavonoid; isoflavonoid