title: Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis.
abstract: One to six percent of patients with microscopic colitis are refractory to medical treatment. The effect of faecal microbiota transplantation (FMT) in active collagenous colitis (CC) has, to the best of our knowledge, never been reported before. Here, we report the effect of repeated FMT in a patient with CC. The patient presented with severe symptoms including profuse diarrhea and profound weight loss. Although she responded to budesonide in the beginning, she became gradually refractory to medical treatment, and was therefore treated with FMT. The patient remained in remission for 11 mo after the third faecal transplantation. The immunomodulatory effect of the therapy was evaluated using flow cytometry, which showed alterations in the profile of intraepithelial and lamina propria lymphocyte subsets after the second transplantation. Our observations indicate that FMT can have an effect in CC, which support the hypothesis that luminal factors, influencing the intestinal microbiota, are involved in the pathogenesis of CC.
authors.affiliation: Sezin Günaltay, Elisabeth Hultgren Hörnquist, Johan Bohr, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, SE-70185 Örebro, Sweden.
authors.forename: Sezin
authors.initials: S
authors.lastname: Günaltay
authors.affiliation: Sezin Günaltay, Elisabeth Hultgren Hörnquist, Johan Bohr, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, SE-70185 Örebro, Sweden.
authors.forename: Lech
authors.initials: L
authors.lastname: Rademacher
authors.affiliation: Sezin Günaltay, Elisabeth Hultgren Hörnquist, Johan Bohr, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, SE-70185 Örebro, Sweden.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Hultgren Hörnquist
authors.affiliation: Sezin Günaltay, Elisabeth Hultgren Hörnquist, Johan Bohr, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, SE-70185 Örebro, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Bohr
mesh_terms: D000368:Aged; D001706:Biopsy; D046729:Colitis, Collagenous / Q000276:immunology / Q000382:microbiology* / Q000628:therapy*; D003093:Colitis, Ulcerative / Q000628:therapy; D003967:Diarrhea; D000069467:Fecal Microbiota Transplantation; D005243:Feces; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D064307:Microbiota
keywords: Collagenous colitis; Faecal microbiota transplantation; Flow cytometry; Lymphocytes; Microbiota