title: A Case Report of Syndrome of Inappropriate Antidiuretic Hormone Induced by Pregabalin.
abstract: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of euvolemic hyponatremia, and many medications have been associated with SIADH. Pregabalin is a drug used for the treatment of neuropathic pain, though common adverse effects include central nervous system disturbance, peripheral edema, and weight gain. However, hyponatremia caused by pregabalin has been rarely reported. Here we report a patient with pregabalin-induced hyponatremia who met the criteria for SIADH; after discontinuation of the drug, his condition rapidly improved. This case can help clinicians diagnose and treat new-onset hyponatremia in patients who recently initiated pregabalin therapy.
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Youn Joo
authors.initials: YJ
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Dong-Young
authors.initials: DY
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Hae Won
authors.initials: HW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Hyun Sun
authors.initials: HS
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Beom
authors.initials: B
authors.lastname: Kim
keywords: Drug associated syndrome of inappropriate antidiuretic hormone secretion; Hyponatremia; Pregabalin