title: Cardio-oncology Related to Heart Failure: Pediatric Considerations for Cardiac Dysfunction.
abstract: Although tremendous advances in pediatric cancer treatment have improved the survival of many children, these patients remain at increased risk of early morbidity and mortality with cardiovascular disease as a leading cause of death. Heightened awareness in providers with increased surveillance and improvement in cardiovascular imaging modalities have led to earlier detection of cardiac dysfunction, but the outcomes remain poor once this has dysfunction developed. A great deal of work remains to be done to refine screening and identify high-risk patients more precisely, and to develop more evidence-based strategies for effective primary and secondary cardioprotection and treatment.
authors.affiliation: Department of Pediatrics, Sibley Heart Center Cardiology, 201 Dowman Drive, Atlanta, GA 30322, USA; Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, 1405 Clifton Road Northeast, Atlanta, GA 30322, USA. Electronic address: rosefelkerk@kidsheart.com.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Rose-Felker
authors.affiliation: Department of Pediatrics, Sibley Heart Center Cardiology, 201 Dowman Drive, Atlanta, GA 30322, USA; Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, 1405 Clifton Road Northeast, Atlanta, GA 30322, USA.
authors.forename: William L
authors.initials: WL
authors.lastname: Border
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, University of Washington, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA.
authors.forename: Borah J
authors.initials: BJ
authors.lastname: Hong
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, PO Box 19024, Seattle, WA 98109, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Chow
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D019317:Evidence-Based Medicine; D006333:Heart Failure / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy / Q000534:rehabilitation*; D017741:Survivors; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents
keywords: Anthracyclines; Cardiac dysfunction; Cardiotoxicity; Childhood cancer survivors