title: KSHV microRNAs: Tricks of the Devil.
abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS), a vascular tumor frequently found in immunodeficient individuals. KSHV encodes 12 pre-microRNAs (pre-miRNAs), which are processed into 25 mature microRNAs (miRNAs). KSHV miRNAs maintain KSHV latency, enhance angiogenesis and dissemination of the infected cells, and interfere with the host immune system by regulating viral and cellular gene expression, ultimately contributing to KS development. In this review, we briefly introduce the biogenesis of miRNAs and then describe the recent advances in defining the roles and mechanisms of action of KSHV miRNAs in KS development.
authors.affiliation: State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, P.R. China; Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, P.R. China; Department of Microbiology, Nanjing Medical University, Nanjing 211166, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Qin
authors.affiliation: State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, P.R. China; Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, P.R. China; Department of Microbiology, Nanjing Medical University, Nanjing 211166, P.R. China.
authors.forename: Wan
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Shou-Jiang
authors.initials: SJ
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, P.R. China. Electronic address: clu@njmu.edu.cn.
authors.forename: Chun
authors.initials: C
authors.lastname: Lu
mesh_terms: D002460:Cell Line; D019288:Herpesvirus 8, Human / Q000235:genetics* / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology; D009389:Neovascularization, Pathologic; D012367:RNA, Viral / Q000235:genetics* / Q000502:physiology; D012514:Sarcoma, Kaposi / Q000503:physiopathology / Q000821:virology*; D014775:Virus Activation; D017735:Virus Latency
chemical_list: D035683:MicroRNAs; D012367:RNA, Viral
keywords: Angiogenesis; KSHV microRNA; Tumor dissemination; Viral latency