title: Epigenetic Mistakes in Neurodevelopmental Disorders.
abstract: Epigenetics is the array of the chromatin modifications that customize in cell-, stage-, or condition-specific manner the information encloses in plain DNA molecules. Increasing evidences suggest the importance of epigenetic mechanisms for development and maintenance of central nervous system. In fact, a large number of newly discovered genetic causes of neurodevelopmental disorders such as intellectual disability, autism spectrum disorders, and many other syndromes are mutations within genes encoding for chromatin remodeling enzymes. Here, we review recent findings on the epigenetic origin of human diseases, with emphasis on disorders that affect development of the nervous system, and discuss novel therapeutic avenues that target epigenetic mechanisms.
authors.affiliation: Division of Neuroscience, San Raffaele Hospital, Via Olgettina 58, 20132, Milan, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Mastrototaro
authors.affiliation: Division of Neuroscience, San Raffaele Hospital, Via Olgettina 58, 20132, Milan, Italy.
authors.forename: Mattia
authors.initials: M
authors.lastname: Zaghi
authors.affiliation: Division of Neuroscience, San Raffaele Hospital, Via Olgettina 58, 20132, Milan, Italy. sessa.alessandro@hsr.it.
authors.forename: Alessandro
authors.identifier: http://orcid.org/0000-0003-3611-5056
authors.initials: A
authors.lastname: Sessa
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D065886:Neurodevelopmental Disorders / Q000235:genetics*
keywords: Epigenetics; Intellectual disability; Neurodevelopmental disorders