title: Two new geranylphenylacetate glycosides from the barks of Cinnamomum cassia.
abstract: Two new glycosides, cinnacassides F (1) and G (2), with a rare geranylphenylacetate carbon skeleton, were isolated from the barks of Cinnamomum cassia, along with three known analogues, cinnacassides A (3), B (4) and C (5). The structures of the new compounds were elucidated on the basis of extensive NMR spectroscopic analyses and chemical method. Compounds 1-5 were investigated for their immunomodulatory activities, and compounds 1, 3 and 4 showed differential immunosuppressive activities against murine lymphocytes.
authors.affiliation: a Department of Pharmacy , Renmin Hospital of Wuhan University , Wuhan , China.
authors.forename: Jun-Fen
authors.initials: JF
authors.lastname: Zeng
authors.affiliation: b Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors.forename: Hu-Cheng
authors.initials: HC
authors.lastname: Zhu
authors.affiliation: a Department of Pharmacy , Renmin Hospital of Wuhan University , Wuhan , China.
authors.forename: Jian-Wu
authors.initials: JW
authors.lastname: Lu
authors.affiliation: c College of Life Science , Hubei University , Wuhan , China.
authors.forename: Lin-Zhen
authors.initials: LZ
authors.lastname: Hu
authors.affiliation: a Department of Pharmacy , Renmin Hospital of Wuhan University , Wuhan , China.
authors.forename: Jin-Chun
authors.initials: JC
authors.lastname: Song
authors.affiliation: b Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors.forename: Yong-Hui
authors.initials: YH
authors.lastname: Zhang
mesh_terms: D000818:Animals; D032904:Cinnamomum aromaticum / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010648:Phenylacetates / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D006027:Glycosides; D007166:Immunosuppressive Agents; D010648:Phenylacetates; C000624886:cinnacasside B
keywords: Cinnamomum cassia; cinnacasside F-G; geranylphenylacetate glycosides; immunosuppressive activity