title: Relationship Between C-Reactive Protein Serum Concentration and the 1846 C>T (rs1205) Polymorphism in Patients with Acute Coronary Syndrome from Western Mexico.
abstract: OBJECTIVE
  To determine the relationship among the 1846 C>T (rs1205) polymorphism, C-reactive protein (CRP) concentration, and interleukin 6 (IL-6) serum levels in patients with acute coronary syndrome (ACS) from Western Mexico.
  
  
  METHODS
  Three hundred participants in the control group (CG) and 300 patients with ACS from Western Mexico were included in the study. Genotyping was performed with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). High-sensitivity CRP (hs-CRP) concentration was measured by immunonephelometry. For IL-6 measurement, we used a solid-phase sandwich Enzyme-Linked Immunosorbent Assay.
  
  
  RESULTS
  Serum CRP concentration was increased in patients compared with controls (19 mg/L vs. 2.00 mg/L; p < 0.0001). ST-segment elevation myocardial infarction exhibited a higher CRP concentration than without elevation (non-ST-segment elevation myocardial infarction) and patients with unstable angina (21.81, 17.10, and 5.91 mg/L; p < 0.01). The rs1205 CRP polymorphism was not associated with ACS; however, T carriers had lower CRP concentrations than C/C (2.80 mg/L vs. 5.20 mg/L; p = 0.004) in CG and ACS (17.76 vs. 21.45; p = 0.046). IL-6 showed a strong positive correlation with CRP concentration in ACS patients (rho = 0.74, p < 0.0001).
  
  
  CONCLUSIONS
  Patients with ACS had increased CRP levels compared with CG, and this appears to be related with ACS clinical spectrum severity. The rs1205 polymorphism is not a susceptibility genetic marker to ACS in Western Mexico population; however, the T allele is associated with lower CRP concentration. Further studies are needed to confirm the prognostic value of ACS and IL-6/CRP correlation, but it could be a reliable test for predicting adverse cardiac events in the Mexican population.
authors.affiliation: 1 Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG) , Edificio Q, Primer piso, Colonia Independencia, Guadalajara, México .|2 Doctorado en Genetica Humana, Centro Universitario de Ciencias de la Salud , Guadalajara, México .
authors.forename: Gabriela Lizet
authors.initials: GL
authors.lastname: Reynoso-Villalpando
authors.affiliation: 1 Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG) , Edificio Q, Primer piso, Colonia Independencia, Guadalajara, México .
authors.forename: Jorge Ramón
authors.initials: JR
authors.lastname: Padilla-Gutiérrez
authors.affiliation: 1 Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG) , Edificio Q, Primer piso, Colonia Independencia, Guadalajara, México .|2 Doctorado en Genetica Humana, Centro Universitario de Ciencias de la Salud , Guadalajara, México .
authors.forename: Angélica
authors.initials: A
authors.lastname: Valdez-Haro
authors.affiliation: 1 Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG) , Edificio Q, Primer piso, Colonia Independencia, Guadalajara, México .|2 Doctorado en Genetica Humana, Centro Universitario de Ciencias de la Salud , Guadalajara, México .
authors.forename: Fidel
authors.initials: F
authors.lastname: Casillas-Muñoz
authors.affiliation: 1 Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG) , Edificio Q, Primer piso, Colonia Independencia, Guadalajara, México .
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Muñoz-Valle
authors.affiliation: 3 Specialty in Cardiology, IMSS, Centro Universitario de Ciencias de la Salud , Guadalajara, México .|4 Unidad Médica de Alta Especialidad, Centro Médico Nacional de Occidente (CMNO), Departamento de Cardiología, Instituto Mexicano del Seguro Social (IMSS) , Guadalajara, México .
authors.forename: Edgar
authors.initials: E
authors.lastname: Castellanos-Nuñez
authors.affiliation: 3 Specialty in Cardiology, IMSS, Centro Universitario de Ciencias de la Salud , Guadalajara, México .|4 Unidad Médica de Alta Especialidad, Centro Médico Nacional de Occidente (CMNO), Departamento de Cardiología, Instituto Mexicano del Seguro Social (IMSS) , Guadalajara, México .
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Chávez-Herrera
authors.affiliation: 1 Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG) , Edificio Q, Primer piso, Colonia Independencia, Guadalajara, México .
authors.forename: Yeminia
authors.initials: Y
authors.lastname: Valle
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000235:genetics; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000235:genetics* / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011379:Prognosis
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein
keywords: C-reactive protein; IL-6; acute coronary syndrome; genetic polymorphism