title: Effects of Hypericum perforatum on an Experimentally Induced Diabetic Wound in a Rat Model.
abstract: OBJECTIVE
  The aim of this study was to investigate the probable effects of Hypericum perforatum (HP) on wound healing in diabetic rats.
  
  
  METHODS
  Thirty-five male Wistar rats were divided evenly into 5 groups. Diabetes formation was induced by intraperitoneal streptozotocin (60 mg/kg) administration for groups 1 (HP extract in olive oil), 2 (HP extract in ethanol), 3 (povidone-iodine application), and 4 (diabetic rats without any applied medication); group 5 was the control. Dorsal dermoepidermal incision was performed on each rat after 48 hours. The aforementioned solutions were applied only to groups 1, 2, and 3; groups 4 and 5 did not receive solution applications. At the end of the 7-day period, the cutaneous tissue was resected from the center of the incised and sutured region and divided into 3 pieces for biomechanical, biochemical, and histopathological assessments.
  
  
  RESULTS
  Ultimate stress and toughness significantly decreased in groups 3, 4, and 5 compared to group 1. There was a significant difference between groups 2 and 3 for the same parameters (P < .05). Compared with group 4, tissue malondialdehyde levels were found to be lower in the HP groups (P < .05). Histopathological evaluation revealed the fibroblast count was reduced considerably in the HP-applied rats compared with other groups (P < .05).
  
  
  CONCLUSIONS
  Application of HP may be recommended as effective on wound healing in diabetic rats, but further investigation is needed to adapt the findings for clinical use.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Farsak
authors.forename: Görkemo
authors.initials: G
authors.lastname: Özdağli
authors.forename: Doğay
authors.initials: D
authors.lastname: Özmüş
authors.forename: Ülkü
authors.initials: Ü
authors.lastname: Çömelekoğlu
authors.forename: Serap
authors.initials: S
authors.lastname: Yalın
authors.forename: Rabia
authors.initials: R
authors.lastname: Bozdoğan Arpacı
authors.forename: Ramazan
authors.initials: R
authors.lastname: Gen
authors.forename: Arzu
authors.initials: A
authors.lastname: Kanık
authors.forename: Derya
authors.initials: D
authors.lastname: Ümit Talas
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D004195:Disease Models, Animal; D020902:Hypericum / Q000737:chemistry*; D008297:Male; D000069463:Olive Oil / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000473:pathology*
chemical_list: D000891:Anti-Infective Agents, Local; D000069463:Olive Oil; D010936:Plant Extracts