title: Is a 1,4-Alkyl Shift Involved in the Biosynthesis of Ledol and Viridiflorol?
abstract: Results from density functional theory computations indicate that a 1,4-alkyl shift proposed as part of the carbocation cyclization/rearrangement leading to ledol, viridiflorol, and related sesquiterpenes is not energetically viable. Instead, a previously proposed mechanism that avoids such a shift is greatly preferred.
authors.affiliation: University of California-Davis , 1 Shields Avenue, Davis, California 95616, United States.
authors.forename: Young J
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: University of California-Davis , 1 Shields Avenue, Davis, California 95616, United States.
authors.forename: Dean J
authors.identifier: 0000-0002-2992-8844
authors.initials: DJ
authors.lastname: Tantillo
mesh_terms: D003500:Cyclization; D012717:Sesquiterpenes / Q000378:metabolism*; D013237:Stereoisomerism; D013729:Terpenes / Q000378:metabolism*
chemical_list: D012717:Sesquiterpenes; D013729:Terpenes; C421806:ledol; C552080:viridiflorol