title: Aquaporins in Digestive System.
abstract: In this chapter, we mainly discuss the expression and function of aquaporins (AQPs ) expressed in digestive system . AQPs in gastrointestinal tract include four members of aquaporin subfamily: AQP1, AQP4, AQP5 and AQP8, and a member of aquaglyceroporin subfamily: AQP3. In the digestive glands, especially the liver, we discuss three members of aquaporin subfamily: AQP1, AQP5 and AQP8, a member of aquaglyceroporin subfamily: AQP9. AQP3 is involved in the diarrhea and inflammatory bowel disease; AQP5 is relevant to gastric carcinoma cell proliferation and migration; AQP9 plays considerable role in glycerol metabolism , urea transport and hepatocellular carcinoma. Further investigation is necessary for specific locations and functions of AQPs in digestive system.
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Anatomy and Neuroscience Center, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Ran
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.|State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing, 100191, China.
authors.forename: Baoxue
authors.initials: B
authors.lastname: Yang
authors.affiliation: The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. zhechuanmei@126.com.
authors.forename: Zhechuan
authors.initials: Z
authors.lastname: Mei
mesh_terms: D000818:Animals; D051398:Aquaporin 1 / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002465:Cell Movement; D049109:Cell Proliferation; D003967:Diarrhea / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D041981:Gastrointestinal Tract / Q000378:metabolism*; D005786:Gene Expression Regulation; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D014508:Urea / Q000378:metabolism; D014867:Water / Q000378:metabolism
chemical_list: C496020:AQP1 protein, human; D020033:Protein Isoforms; D014867:Water; D051398:Aquaporin 1; D014508:Urea; D005990:Glycerol
keywords: Aquaporins; Diabetes; Digestive system; Gastrointestinal tract; Glycerol metabolism; Water electrolyte balance