title: Decreased transcriptional corepressor p107 is associated with exercise-induced mitochondrial biogenesis in human skeletal muscle.
abstract: Increased mitochondrial content is a hallmark of exercise-induced skeletal muscle remodeling. For this process, considerable evidence underscores the involvement of transcriptional coactivators in mediating mitochondrial biogenesis. However, our knowledge regarding the role of transcriptional corepressors is lacking. In this study, we assessed the association of the transcriptional corepressor Rb family proteins, Rb and p107, with endurance exercise-induced mitochondrial adaptation in human skeletal muscle. We showed that p107, but not Rb, protein levels decrease by 3 weeks of high-intensity interval training. This is associated with significant inverse association between p107 and exercise-induced improved mitochondrial oxidative phosphorylation. Indeed, p107 showed significant reciprocal correlations with the protein contents of representative markers of mitochondrial electron transport chain complexes. These findings in human skeletal muscle suggest that attenuated transcriptional repression through p107 may be a novel mechanism by which exercise stimulates mitochondrial biogenesis following exercise.
authors.affiliation: Stem Cell Research Group, Molecular, Cellular and Integrative Physiology, Faculty of Health York University, Toronto, Canada.|Molecular, Cellular and Integrative Physiology, Faculty of Health York University, Toronto, Canada.
authors.forename: Debasmita
authors.initials: D
authors.lastname: Bhattacharya
authors.affiliation: Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Mia
authors.initials: M
authors.lastname: Ydfors
authors.affiliation: Molecular, Cellular and Integrative Physiology, Faculty of Health York University, Toronto, Canada.
authors.forename: Meghan C
authors.initials: MC
authors.lastname: Hughes
authors.affiliation: Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Jessica
authors.initials: J
authors.lastname: Norrbom
authors.affiliation: Molecular, Cellular and Integrative Physiology, Faculty of Health York University, Toronto, Canada.
authors.forename: Christopher G R
authors.initials: CG
authors.lastname: Perry
authors.affiliation: Stem Cell Research Group, Molecular, Cellular and Integrative Physiology, Faculty of Health York University, Toronto, Canada ascime@yorku.ca.|Molecular, Cellular and Integrative Physiology, Faculty of Health York University, Toronto, Canada.
authors.forename: Anthony
authors.initials: A
authors.lastname: Scimè
mesh_terms: D000328:Adult; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D001678:Organelle Biogenesis; D010085:Oxidative Phosphorylation; D010807:Physical Endurance / Q000502:physiology; D016160:Retinoblastoma Protein / Q000235:genetics / Q000378:metabolism; D050720:Retinoblastoma-Like Protein p107 / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
chemical_list: C493844:RBL1 protein, human; D016160:Retinoblastoma Protein; D050720:Retinoblastoma-Like Protein p107
keywords: 
  OXPHOS
  ; Exercise; Rb family; human; mitochondrial biogenesis