title: Symmetry assisted tuning of bending and brittle multi-component forms of probenecid.
abstract: The mechanical flexibility known in the antihyperuricemia drug probenecid has been extended into multi-component systems using co-formers with two donor or acceptor sites, in contrast to systems with a single H-bond acceptor that exhibit brittle behaviour. The piperazinium salt demonstrates that GRAS co-formers can be used to maintain mechanical flexibility with drug molecules.
authors.affiliation: Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Ireland. simon.lawrence@ucc.ie.
authors.forename: U B
authors.identifier: http://orcid.org/0000-0003-1823-3630
authors.initials: UB
authors.lastname: Rao Khandavilli
authors.affiliation: Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Ireland. simon.lawrence@ucc.ie.
authors.forename: Balakrishna R
authors.initials: BR
authors.lastname: Bhogala
authors.affiliation: Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland.
authors.forename: Anita R
authors.identifier: http://orcid.org/0000-0001-8306-1893
authors.initials: AR
authors.lastname: Maguire
authors.affiliation: Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Ireland. simon.lawrence@ucc.ie.
authors.forename: Simon E
authors.identifier: http://orcid.org/0000-0001-9430-7983
authors.initials: SE
authors.lastname: Lawrence