title: Syk expression and IgE-mediated histamine release in basophils as biomarkers for predicting the clinical efficacy of omalizumab.
authors.affiliation: Division of Clinical Allergy and Immunology, Johns Hopkins University, Baltimore, Md. Electronic address: macglas@jhmi.edu.
authors.forename: Donald W
authors.initials: DW
authors.lastname: MacGlashan
authors.affiliation: Division of Clinical Allergy and Immunology, Johns Hopkins University, Baltimore, Md.
authors.forename: Sarbjit S
authors.initials: SS
authors.lastname: Saini
mesh_terms: D000328:Adult; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy*; D001491:Basophils / Q000187:drug effects* / Q000502:physiology; D054316:Biomarkers, Pharmacological / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D005786:Gene Expression Regulation; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D008297:Male; D000069444:Omalizumab / Q000627:therapeutic use*; D011379:Prognosis; D011788:Quality of Life; D057566:Self Report; D000072377:Syk Kinase / Q000235:genetics / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D018927:Anti-Asthmatic Agents; D054316:Biomarkers, Pharmacological; D000069444:Omalizumab; D007073:Immunoglobulin E; D000072377:Syk Kinase