title: Reversible phosphorylation of the 26S proteasome.
abstract: The 26S proteasome at the center of the ubiquitin-proteasome system (UPS) is essential for virtually all cellular processes of eukaryotes. A common misconception about the proteasome is that, once made, it remains as a static and uniform complex with spontaneous and constitutive activity for protein degradation. Recent discoveries have provided compelling evidence to support the exact opposite insomuch as the 26S proteasome undergoes dynamic and reversible phosphorylation under a variety of physiopathological conditions. In this review, we summarize the history and current understanding of proteasome phosphorylation, and advocate the idea of targeting proteasome kinases/phosphatases as a new strategy for clinical interventions of several human diseases.
authors.affiliation: The Life Sciences Institute of Zhejiang University, Hangzhou, 310058, China. xguo@zju.edu.cn.
authors.forename: Xing
authors.identifier: 0000-0002-9794-1725
authors.initials: X
authors.lastname: Guo
authors.affiliation: Ministry of Education Key Laboratory of Protein Science, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Xiuliang
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA, 94080, USA.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Chen
mesh_terms: D000818:Animals; D006801:Humans; D010749:Phosphoprotein Phosphatases / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation / Q000235:genetics; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism*; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease
keywords: kinase; phosphatase; phosphorylation; proteasome; protein degradation