title: Breaking Symmetry - Asymmetric Histone Inheritance in Stem Cells.
abstract: Asymmetric cell division (ACD) gives rise to two daughter cells with distinct fates. ACD is widely used during development and by many types of adult stem cells during tissue homeostasis and regeneration. ACD can be regulated by extrinsic cues, such as signaling molecules, as well as by intrinsic factors, such as organelles and cortex proteins. The recent discovery of asymmetric histone inheritance during stem cell ACD has revealed another intrinsic mechanism by which ACD produces two distinct daughters. In this review we discuss these findings in the context of cell-cycle regulation, as well as other studies of ACD, to begin understanding the underlying mechanisms and biological relevance of this phenomenon.
authors.affiliation: Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Wooten
authors.affiliation: Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA; Current address: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North Seattle, Seattle, WA 98109, USA.
authors.forename: Vuong
authors.initials: V
authors.lastname: Tran
authors.affiliation: Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: xchen32@jhu.edu.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
mesh_terms: D060049:Asymmetric Cell Division; D006657:Histones / Q000378:metabolism*; D006801:Humans; D013234:Stem Cells / Q000378:metabolism*
chemical_list: D006657:Histones