title: Excretion rates of 1,5-anhydro-D-glucitol, uric acid and microalbuminuria as glycemic control indexes in patients with type 2 diabetes.
abstract: 1,5-anhydroglucitol (1,5-AG), uric acid and urinary proteins are excreted into the urine with increasing glucosuria. In the present retrospective study we analyzed whether these factors could be used as indicators for type 2 diabetes mellitus (T2DM) glucose control in 6,766 (T2DM) patients. There were 3,988 cases (58.9%) with HbA1c ≤ 6.5%, 853 cases (12.61%) with HbA1c levels ranging from 6.5% to 7% and 1,925 cases (28.5%) with HbA1c > 7%. HbA1c percentages were correlated with age, MA and 1,5-AG serum concentrations (P < 0.001). The serum uric acid concentration (P < 0.001) was significantly lower in elevated MA (P < 0.001) and 24-hour urinary protein (P = 0.024) patients. Hb1Ac percentages (P < 0.001) were significantly enhanced in patients with 1,5-AG serum concentrations ≤10 mg/L compared to >10 mg/L. With a derived receiver operating characteristic (ROC) curve, a 1,5-AG cut-off value of 11.55 mg/L for hyperglycemia could be diagnosed with a specificity of 71.2 (69.7-72.6) and a sensitivity of 75.3 (73.6-76.9). The serum 1,5-AG concentration is a marker for hyperglycemia and may be particularly useful as an indicator for short-term glycemic excursions in order to improve treatments in T2DM patients.
authors.affiliation: Department of Endocrinology, Xuhui District Central Hospital, No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Nephrology, Xuhui District Central Hospital, No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Junqin
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Department of Endocrinology, Xuhui District Central Hospital, No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, No. 639 Zhizaoju Road, Shanghai 200011, China.
authors.forename: Minghao
authors.initials: M
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism*; D003847:Deoxyglucose / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D003847:Deoxyglucose; D006442:Glycated Hemoglobin; D014527:Uric Acid; C006584:1,5-anhydroglucitol