title: The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract.
abstract: Many studies show that the human microbiome plays a critical role in the chronic pathologies of obesity, inflammatory bowel diseases, and diabetes. More recently, the interaction between cancer and the microbiome has been highlighted. Most studies have focused on the gut microbiota because it represents the most extensive bacterial community, and the body of evidence correlating it with gut syndromes is increasing. However, in the strict sense, the gastrointestinal (GI) tract begins in the oral cavity, and special attention should be paid to the specific flora of this cavity. This study reviewed the current knowledge about the various microbial ecosystems of the upper part of the GI tract and discussed their potential link to carcinogenesis. The overall composition of the microbial communities, as well as the presence or absence of "key species", in relation to carcinogenesis is addressed. Alterations in the oral microbiota can potentially be used to predict the risk of cancer. Molecular advances and the further monitoring of the microbiota will increase our understanding of the role of the microbiota in carcinogenesis and open new perspectives for future therapeutic and prophylactic modalities.
authors.affiliation: a UFR d'odontologie, UIC Odontologie, CHU hôtel-Dieu, Université de Nantes, 1, place Alexis Ricordeau, B.P. 84215, 44042 Nantes CEDEX 1, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Le Bars
authors.affiliation: b Walloon Excellence in Life Sciences and Biotechnology, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, 1, place de l'Université, 1348 Brussels, Belgium.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Matamoros
authors.affiliation: c EA 3826 Thérapeutiques cliniques et expérimentales des infections, Faculté de médecine, CHU hôtel-Dieu, Université de Nantes, 1, rue G. Veil, 44000 Nantes, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Montassier
authors.affiliation: d Biofortis Innovation Services - Mérieux NutriSciences, 3, route de la Chatterie, 44800 Saint-Herblain, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Le Vacon
authors.affiliation: c EA 3826 Thérapeutiques cliniques et expérimentales des infections, Faculté de médecine, CHU hôtel-Dieu, Université de Nantes, 1, rue G. Veil, 44000 Nantes, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Potel
authors.affiliation: a UFR d'odontologie, UIC Odontologie, CHU hôtel-Dieu, Université de Nantes, 1, place Alexis Ricordeau, B.P. 84215, 44042 Nantes CEDEX 1, France.
authors.forename: Assem
authors.initials: A
authors.lastname: Soueidan
authors.affiliation: a UFR d'odontologie, UIC Odontologie, CHU hôtel-Dieu, Université de Nantes, 1, place Alexis Ricordeau, B.P. 84215, 44042 Nantes CEDEX 1, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Jordana
authors.affiliation: c EA 3826 Thérapeutiques cliniques et expérimentales des infections, Faculté de médecine, CHU hôtel-Dieu, Université de Nantes, 1, rue G. Veil, 44000 Nantes, France.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: de La Cochetière
mesh_terms: D004067:Digestive System Neoplasms / Q000382:microbiology*; D000069196:Gastrointestinal Microbiome; D006801:Humans; D064307:Microbiota; D009055:Mouth / Q000382:microbiology*; D009059:Mouth Diseases / Q000382:microbiology
keywords: carcinogenesis; carcinogenèse; cavité orale; microbiome; oral cavity; upper aerodigestive; voie aérodigestives supérieures