title: Prognostic factors of left ventricle function deterioration in patients with coronary disease and normal results of echocardiographic examination in a 2-year observation - prospective cohort study.
abstract: BACKGROUND
  Coronary disease is one of the strongest risk factors of developing heart failure. Identification of the predictive factors of left ventricle (LV) function deterioration in patients with stable angina pectoris and normal systolic function of LV, is a challenge for clinicians.
  
  
  OBJECTIVE
  Identification of prognostic factors: clinical, echocardiographic, biochemical (NT-proBNP, hsCRP) and spiroergometric of left ventricle function deterioration in patients with coronary disease and normal results of baseline echocardiographic examination in a 2-year observation.
  
  
  METHODS
  The study group comprised of 32 patients with stable angina pectoris and normal heart function, aged 50.9 ± 4 years; 23 men (71.8%). At baseline we performed echocardiography, cardiopulmonary exercise testing and determined serum levels of B-type natriuretic peptide and C-reactive protein. 24 months later we performed echocardiography and cardiopulmonary exercise testing.
  
  
  RESULTS
  Patients with stable angina pectoris and normal LV function are at risk of developing the impairment of LV function. Diastolic dysfunctions of LV are a crucial element of the whole clinical picture. 53.1% developed of LV diastolic dysfunction: 37% isovolumetric relaxation disorders and 15% pseudonormalization. The analysis of the tests carried out after a 2-year observation indicated a relation-ship between developing diastolic dysfunction of LV and the presence of type II diabetes (p = 0.01). Peak oxygen consumption (VO2peak) at baseline was significantly lower in patients who developed diastolic dysfunction of LV a er 2 years (p = 0.03).
  
  
  CONCLUSIONS
  The predictors of LV diastolic function deterioration in a 2-year observation in this group of patients include type II diabetes and peak oxygen consumption VO2peak.
authors.affiliation: John Paul II Hospital; Department of Medical Education, Jagiellonian University School of Medicine, św. Łazarza 16, Kraków, Poland. agnieszka.skrzypek@gmail.com.
authors.forename: Agnieszka Barbara
authors.initials: AB
authors.lastname: Skrzypek
authors.forename: Stanisław
authors.initials: S
authors.lastname: Górski
authors.forename: Magdalena
authors.initials: M
authors.lastname: Wilczyńska-Golonka
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Nessler
mesh_terms: D000328:Adult; D060050:Angina, Stable / Q000150:complications* / Q000503:physiopathology*; D015331:Cohort Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology*
keywords: dysfunction of left ventricle; patients with stable angina pectoris; prognostic factors of left ventricle dysfunction