title: Nasal polyposis in cystic fibrosis: follow-up of children and adolescents for a 3-year period.
abstract: BACKGROUND
  Nasal polyposis is often found in patients with cystic fibrosis.
  
  
  OBJECTIVE
  To assess the incidence of nasal polyposis, the response to medical treatment, recurrence and the need for surgical intervention in children and adolescents with cystic fibrosis during a three-year follow-up.
  
  
  METHODS
  Clinical symptoms (pulmonary, pancreatic insufficiency, malnutrition, nasal obstruction), two positive sweat chloride tests, and genotype findings in 23 patients with cystic fibrosis were analyzed. All patients underwent nasal endoscopy every 12 months from January 2005 to December 2007, to assess the presence and grade of Nasal Polyps. Nasal polyposis, when present, were treated with topical corticosteroids for 6-12 months, with progress being evaluated within the 3 years of follow-up.
  
  
  RESULTS
  In the first evaluation, nasal polyposis was diagnosed in 30.43% of patients (3 bilateral and 4 unilateral), recurrent pneumonia in 82.6%, pancreatic insufficiency in 87%, and malnutrition in 74%. The presence of nasal polyposis was not associated with chloride values in the sweat, genotype, clinical signs of severity of cystic fibrosis, or nasal symptoms. In the three-year period of follow up, 13 patients (56.52%) had at least one event of polyposis, with the youngest being diagnosed at 32 months of age. Only one patient underwent surgery (polypectomy), and there was one diagnosis of nasopharyngeal carcinoma.
  
  
  CONCLUSIONS
  The study showed a high incidence of nasal polyposis. Monitoring through routine endoscopy in patients with cystic fibrosis, even in the absence of nasal symptoms, is highly recommended. The therapy with topical corticosteroids achieved good results. Thus, an interaction between pediatricians and otolaryngologists is necessary.
authors.affiliation: Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Medicina de Botucatu, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Botucatu, SP, Brazil. Electronic address: silke@fmb.unesp.br.
authors.forename: Silke Anna Theresa
authors.initials: SAT
authors.lastname: Weber
authors.affiliation: Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Medicina de Botucatu, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Botucatu, SP, Brazil.
authors.forename: Renata Mizusaki
authors.initials: RM
authors.lastname: Iyomasa
authors.affiliation: Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Medicina de Botucatu, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Botucatu, SP, Brazil.
authors.forename: Camila de Castro
authors.initials: CC
authors.lastname: Corrêa
authors.affiliation: Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Medicina de Botucatu, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Botucatu, SP, Brazil.
authors.forename: Wellington Novais Mafra
authors.initials: WNM
authors.lastname: Florentino
authors.affiliation: Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Medicina de Botucatu, Departamento de Pediatria, Botucatu, SP, Brazil.
authors.forename: Giesela Fleischer
authors.initials: GF
authors.lastname: Ferrari
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D009296:Nasal Cavity / Q000000981:diagnostic imaging / Q000473:pathology; D009298:Nasal Polyps / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods; D011446:Prospective Studies; D012008:Recurrence; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Cystic fibrosis; Diagnosis; Diagnóstico; Endoscopia; Endoscopy; Fibrose cística; Polipose; Polyposis; Terapia; Therapy