title: An Overview on Current Issues and Challenges of Endothelial Progenitor Cell-Based Neovascularization in Patients with Diabetic Foot Ulcer.
abstract: Diabetic foot ulcer's impaired wound healing, which leads to the development of chronic non-healing wounds and ultimately amputation, is a major problem worldwide. Although recently endothelial progenitor cell-derived cell therapy has been used as a therapeutic intervention to treat diabetic wounds, thereby promoting neovascularization, the results, however, are not satisfactory. In this article, we have discussed the several steps that are involved in the neovascularization process, which might be impaired during diabetes. In addition, we have also discussed the reported possible interventions to correct these impairments. Thus, we have summarized neovascularization as a process with a coordinated sequence of multiple steps and thus, there is the need of a combined therapeutic approach to achieve better treatment outcomes.
authors.affiliation: Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University , Shanghai, People's Republic of China .
authors.forename: Sushant Kumar
authors.initials: SK
authors.lastname: Das
authors.affiliation: Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University , Shanghai, People's Republic of China .
authors.forename: Yi Feng
authors.initials: YF
authors.lastname: Yuan
authors.affiliation: Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University , Shanghai, People's Republic of China .
authors.forename: Mao Quan
authors.initials: MQ
authors.lastname: Li
mesh_terms: D000818:Animals; D017719:Diabetic Foot / Q000473:pathology / Q000628:therapy*; D066026:Endothelial Progenitor Cells / Q000166:cytology*; D006801:Humans; D018919:Neovascularization, Physiologic; D014945:Wound Healing
keywords: autophagy; diabetic foot ulcer; endothelial progenitor cells; neovascularization