title: Oxidative balance score and serum γ-glutamyltransferase level among Korean adults: a nationwide population-based study.
abstract: OBJECTIVE
  The oxidative balance score (OBS) comprises dietary and non-dietary lifestyle pro-oxidants and antioxidants. Elevated serum γ-glutamyltransferase (GGT) level has currently emerged as a biomarker of oxidative stress. In this study, we examined whether OBS was inversely associated with serum GGT level and whether OBS could be a useful marker to predict GGT among Korean adults.
  
  
  METHODS
  This cross-sectional study was based on data obtained from the 2010 and 2011 Korea National Health and Nutrition Examination Survey. 2087 men and 2071 women were included in final analysis. The OBS was divided into five equal interval categories, and GGT was dichotomized into low and high using its sex-specific median value. Multiple logistic regression analysis was conducted to assess the association between OBS categories and high GGT.
  
  
  RESULTS
  Compared with the lowest OBS category as reference, the multivariable adjusted ORs (95% CIs) for the highest OBS category of men and women were 0.05 (0.01-0.19) and 0.27 (0.09-0.78), respectively (p for trend <0.01).
  
  
  CONCLUSIONS
  A higher OBS that indicates a predominance of antioxidant over pro-oxidant exposure was strongly inversely associated with GGT level among Korean adults.
authors.affiliation: Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 135-720, Republic of Korea.
authors.forename: A-Ra
authors.initials: AR
authors.lastname: Cho
authors.affiliation: Department of Family Medicine, Yong-in Severance Hospital, Yonsei University College of Medicine, Yong-in City, Republic of Korea.
authors.forename: Yu-Jin
authors.initials: YJ
authors.lastname: Kwon
authors.affiliation: Department of Family Medicine, Chungbuk National University Hospital College, Cheongju, Republic of Korea.
authors.forename: Hyoung-Ji
authors.initials: HJ
authors.lastname: Lim
authors.affiliation: Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hye Sun
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Sinae
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jae-Yong
authors.initials: JY
authors.lastname: Shim
authors.affiliation: Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 135-720, Republic of Korea.
authors.forename: Hye-Ree
authors.initials: HR
authors.lastname: Lee
authors.affiliation: Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 135-720, Republic of Korea. ukyjhome@yuhs.ac.
authors.forename: Yong-Jae
authors.initials: YJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004032:Diet / Q000009:adverse effects* / Q000208:ethnology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D050177:Overweight / Q000097:blood* / Q000208:ethnology / Q000209:etiology / Q000276:immunology; D018384:Oxidative Stress; D056910:Republic of Korea; D057185:Sedentary Behavior / Q000208:ethnology; D015854:Up-Regulation; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human
keywords: Biomarker; Inflammation; Oxidative balance score; Oxidative stress; γ-Glutamyltransferase