title: Prospective study of percutaneous cryoablation combined with allogenic NK cell immunotherapy for advanced renal cell cancer.
abstract: In this study, the clinical efficacy of cryosurgery combined with allogenic NK cell immunotherapy for advanced renal cell cancer was evaluated. From July to December 2016, we enrolled 60 patients who met the enrollment criteria and divided them into two groups: (1) the simple cryoablation group (n=30); and (2) the cryoablation combined with allogenic NK cells group (n=30). The clinical efficacy, quality of life, immune function, and other related indicators were evaluated. Combining allogeneic NK cells with cryoablation had a synergistic effect, not only enhancing the immune function and improving the quality of life of the patients, but also significantly exhibiting good clinical efficacy of the patients. This study is the first clinical trial that has evaluated the safety and efficacy of allogenic NK cells combined with cryosurgery for the treatment of renal cell cancer.
authors.affiliation: Department of Biological Treatment Center, Fuda Cancer Hospital, Jinan University School of Medicine, China; Fuda Cancer Institute, Guangzhou, China.
authors.forename: Mao
authors.initials: M
authors.lastname: Lin
authors.affiliation: Department of Biological Treatment Center, Fuda Cancer Hospital, Jinan University School of Medicine, China; Fuda Cancer Institute, Guangzhou, China.
authors.forename: Kecheng
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Biological Treatment Center, Fuda Cancer Hospital, Jinan University School of Medicine, China.
authors.forename: Shuzhen
authors.initials: S
authors.lastname: Liang
authors.affiliation: Department of Biological Treatment Center, Fuda Cancer Hospital, Jinan University School of Medicine, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Biological Treatment Center, Fuda Cancer Hospital, Jinan University School of Medicine, China.
authors.forename: Yinqing
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Hank Bioengineering Co., Ltd, Shenzhen, China.
authors.forename: Mingjie
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Biological Treatment Center, Fuda Cancer Hospital, Jinan University School of Medicine, China; Fuda Cancer Institute, Guangzhou, China. Electronic address: linmaogz@163.com.
authors.forename: Jibing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Biological Treatment Center, Fuda Cancer Hospital, Jinan University School of Medicine, China; Fuda Cancer Institute, Guangzhou, China; Department of Oncology, Fuda Cancer Hospital, Jinan University School of Medicine, China. Electronic address: 18922210657@163.com.
authors.forename: LiZhi
authors.initials: L
authors.lastname: Niu
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*; D003131:Combined Modality Therapy; D003452:Cryosurgery / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects / Q000379:methods; D007677:Kidney Function Tests; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011446:Prospective Studies; D011788:Quality of Life; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: Allogenic NK cell; Clinical efficacy; Clinical trial; Percutaneous cryoablation; Renal cell cancer