title: Blood Biomarkers Predict the Cognitive Effects of Aripiprazole in Patients with Acute Schizophrenia.
abstract: Aripiprazole has been reported to exert variable effects on cognitive function in patients with schizophrenia. Therefore, in the present study, we evaluated biological markers, clinical data, and psychiatric symptoms in order to identify factors that influence cognitive function in patients with schizophrenia undergoing aripiprazole treatment. We evaluated cognitive function in 51 patients with schizophrenia using Brief Assessment of Cognition in Schizophrenia (BACS), as well as background information, psychiatric symptoms, plasma catecholamine metabolites-homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG)-, and serum brain-derived neurotrophic factor (BDNF). Multivariate analyses were performed in order to identify factors independently associated with cognitive function. Brain-derived neurotrophic factor levels, number of hospitalizations, and MHPG levels were associated with verbal memory and learning. Total hospitalization period and MHPG levels were associated with working memory. Age at first hospitalization and education were associated with motor speed. The number of hospital admissions, Positive and Negative Syndrome Scale negative subscale scores (PANSS-N), MHPG levels, BDNF levels, and Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS) scores were associated with verbal fluency. Homovanillic acid and MHPG levels, duration of illness, and PANSS-N scores were associated with attention and processing speed. Brain-derived neurotrophic factor and MHPG levels were associated with executive function. These results suggest that treatment of psychiatric symptoms and cognitive dysfunction may be improved in patients treated with aripiprazole by controlling for these contributing factors.
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 8078555, Japan. hori-h@med.uoeh-u.ac.jp.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Hori
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 8078555, Japan. yoshi621@med.uoeh-u.ac.jp.
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 8078555, Japan. asuka-k@med.uoeh-u.ac.jp.
authors.forename: Asuka
authors.initials: A
authors.lastname: Katsuki
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 8078555, Japan. k-atake@med.uoeh-u.ac.jp.
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Atake
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 8078555, Japan. igataryouhei@gmail.com.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Igata
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 8078555, Japan. konikoni0125@hotmail.co.jp.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Konishi
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 8078555, Japan. hirokibeppu0928@hotmail.co.jp.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Beppu
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 8078555, Japan. inevitable_instinct77@yahoo.co.jp.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Tominaga
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000068180:Aripiprazole / Q000009:adverse effects* / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003071:Cognition / Q000187:drug effects*; D056344:Executive Function / Q000187:drug effects; D005260:Female; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D008734:Methoxyhydroxyphenylglycol / Q000097:blood*; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D008734:Methoxyhydroxyphenylglycol; D000068180:Aripiprazole; D006719:Homovanillic Acid
keywords: aripiprazole; brain-derived neurotrophic factor; cognitive function; schizophrenia