title: Design, Network Analysis and In Silico Modeling of Biologically Significant 4-(substituted benzyl)-2-Amino-6-HydroxyPyrimidine-5-Carboxamide Nanoparticles.
abstract: The synthesized 4-(4-hydroxy benzyl)-2-amino-6-hydroxy pyrimidine-5-carboxamide was chosen to perform in silico modeling with identified drug target AGT, TNF, F2 and BCL2L1. The identified human proteins are vital in the pain management and also an important target for the study of wound healing activity. The enzymes were identified by using BioGRID, string database and network analysis through Cytoscape software. The wound healing activity was evaluated by excision wound model. The observed results revealed that, the pyrimidine nanoparticles showed significant wound healing activity compared to standard and synthesized compound. The detailed synthesis of nanoparticles formulation spectral analysis and pharmacological screening data's were reported. The revealed reports of synthesized analogues and formulated nanoparticles will generate a very good impact to the chemists and research scholars for further investigations in wound healing and pain management.
authors.affiliation: International Research Centre, Kalasalingam University, Anand Nagar, Krishnankoil, Tamilnadu, India.
authors.forename: Theivendren
authors.initials: T
authors.lastname: Panneerselvam
authors.affiliation: Department of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil, Tamilnadu, India.
authors.forename: Vellaichamy
authors.initials: V
authors.lastname: Sivakumar
authors.affiliation: National Centre for Advanced Research in Discrete Mathematics, Kalasalingam University, Anand nagar, Krishnankoil, Tamilnadu, India.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Arumugam
authors.affiliation: International Research Centre, Kalasalingam University, Anand Nagar, Krishnankoil, Tamilnadu, India.
authors.forename: Kunjiappan
authors.initials: K
authors.lastname: Selvaraj
authors.affiliation: Department of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil, Tamilnadu, India.
authors.forename: Murugan
authors.initials: M
authors.lastname: Indhumathy
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003198:Computer Simulation; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D059408:Pain Management / Q000379:methods; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D014945:Wound Healing / Q000187:drug effects
chemical_list: D011743:Pyrimidines; C030986:pyrimidine