title: Two new α-pyrone derivatives from an endolichenic fungus Tolypocladium sp.
abstract: Two new α-pyrone derivatives, tolypocladones A (1) and B (2), together with five known compounds were isolated from an endolichenic fungus Tolypocladium sp. (4259a). The structures of all the compounds were determined by analysis of their MS and NMR data. Among them, compound 1 was an enantiomeric mixture and the configuration was established by single-crystal X-ray diffraction analysis using Cu-Kα radiation. Also, this is the first report of the presence of compound 3 (glycine, N-(2,3-dihydroxybenzoyl)-methyl ester) and compound 4 (2H-pyran-2-one, 4-methoxy-6-(1,3-pentadienyl)) as natural products.
authors.affiliation: a Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education , Shandong University , Jinan 250012 , China.
authors.forename: Chu-Hong
authors.initials: CH
authors.lastname: Hu
authors.affiliation: a Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education , Shandong University , Jinan 250012 , China.
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Zhou
authors.affiliation: a Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education , Shandong University , Jinan 250012 , China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xie
authors.affiliation: a Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education , Shandong University , Jinan 250012 , China.
authors.forename: Yue-Lan
authors.initials: YL
authors.lastname: Li
authors.affiliation: a Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education , Shandong University , Jinan 250012 , China.
authors.forename: Zun-Tian
authors.initials: ZT
authors.lastname: Zhao
authors.affiliation: a Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education , Shandong University , Jinan 250012 , China.
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D002681:China; D018360:Crystallography, X-Ray; D008011:Lichens / Q000382:microbiology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D011753:Pyrones; C000621832:tolypocladone A; C000621834:tolypocladone B
keywords: Endolichenic fungus; Tolypocladium sp; α-pyrone derivative