title: Comparison Between Spectral-Domain and Swept-Source Optical Coherence Tomography Angiographic Imaging of Choroidal Neovascularization.
abstract: The purpose of this study was to compare imaging of choroidal neovascularization (CNV) using swept-source (SS) and spectral-domain (SD) optical coherence tomography angiography (OCTA).
  
  
  
  Optical coherence tomography angiography was performed using a 100-kHz SS-OCT instrument and a 68-kHz SD-OCTA instrument (Carl Zeiss Meditec, Inc.). Both 3 × 3- and 6 × 6-mm2 scans were obtained on both instruments. The 3 × 3-mm2 SS-OCTA scans consisted of 300 A-scans per B-scan at 300 B-scan positions, and the SD-OCTA scans consisted of 245 A-scans at 245 B-scan positions. The 6 × 6-mm2 SS-OCTA scans consisted of 420 A-scans per B-scan at 420 B-scan positions, and the SD-OCTA scans consisted of 350 A-scans and 350 B-scan positions. B-scans were repeated four times at each position in the 3 × 3-mm2 scans and twice in the 6 × 6-mm2 scans. Choroidal neovascularization was excluded if not fully contained within the 3 × 3-mm2 scans. The same algorithm was used to detect CNV on both instruments. Two graders outlined the CNV, and the lesion areas were compared between instruments.
  
  
  
  Twenty-seven consecutive eyes from 23 patients were analyzed. For the 3 × 3-mm2 scans, the mean lesion areas for the SS-OCTA and SD-OCTA instruments were 1.17 and 1.01 mm2, respectively (P = 0.047). For the 6 × 6-mm2 scans, the mean lesion areas for the SS-OCTA and SD-OCTA instruments were 1.24 and 0.74 mm2 (P = 0.003).
  
  
  
  The areas of CNV tended to be larger when imaged with SS-OCTA than with SD-OCTA, and this difference was greater for the 6 × 6-mm2 scans.
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Miller
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States 2Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Luiz
authors.initials: L
authors.lastname: Roisman
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington, United States.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Fang
authors.initials: F
authors.lastname: Zheng
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Joao
authors.initials: J
authors.lastname: Rafael de Oliveira Dias
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Zohar
authors.initials: Z
authors.lastname: Yehoshua
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Karen B
authors.initials: KB
authors.lastname: Schaal
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: William
authors.initials: W
authors.lastname: Feuer
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gregori
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington, United States.
authors.forename: Zhongdi
authors.initials: Z
authors.lastname: Chu
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington, United States.
authors.forename: Chieh-Li
authors.initials: CL
authors.lastname: Chen
authors.affiliation: Advanced Development, Carl Zeiss Meditec, Inc., Dublin, California, United States.
authors.forename: Sophie
authors.initials: S
authors.lastname: Kubach
authors.affiliation: Advanced Development, Carl Zeiss Meditec, Inc., Dublin, California, United States.
authors.forename: Lin
authors.initials: L
authors.lastname: An
authors.affiliation: Advanced Development, Carl Zeiss Meditec, Inc., Dublin, California, United States.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Stetson
authors.affiliation: Advanced Development, Carl Zeiss Meditec, Inc., Dublin, California, United States.
authors.forename: Mary K
authors.initials: MK
authors.lastname: Durbin
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington, United States.
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenfeld
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000098:blood supply* / Q000473:pathology; D020256:Choroidal Neovascularization / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity