title: Participation of Leukotrienes in the Immune Modulation of Oral Tolerance.
abstract: Oral tolerance (OT) is characterized as a peripheral immune tolerance form, in which, mature lymphocytes in lymphoid tissues associated with mucosa, become non-functional or hypo responsive due to prior oral administration of antigen. OT is an important immunological phenomenon due to its therapeutic potential in inflammatory processes and others diseases. Here we evaluated leukotriene role in the induction of OT, as well as, the production of cytokines IL-5 and IFN-γ in leukotriene deficient animals (knock-out). Our results suggested that even in the presence of OT and leukotrienes absence, cytokine IFN-γ remains being secreted, which gives us an indication of immune system specificity and also that IFN-γ participates in various immune processes.
authors.affiliation: Laboratory of Parasitology, Department of Morphology and Pathology, Universidade Federal de São Carlos São Carlos, Brazil.
authors.forename: Sandra R P
authors.initials: SR
authors.lastname: de Oliveira
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto - University of São Paulo Ribeirão Preto, Brazil.
authors.forename: Auro
authors.initials: A
authors.lastname: Nomizo
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto - University of São Paulo Ribeirão Preto, Brazil.
authors.forename: Fabiani G
authors.initials: FG
authors.lastname: Frantz
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto - University of São Paulo Ribeirão Preto, Brazil.
authors.forename: Lúcia H
authors.initials: LH
authors.lastname: Faccioli
authors.affiliation: Laboratory of Parasitology, Department of Morphology and Pathology, Universidade Federal de São CarlosSão Carlos, Brazil; Universidade de São Paulo, Escola de Enfermagem de Ribeirão Preto, Ribeirão PretoBrazil.
authors.forename: Ana Paula Keller
authors.initials: AP
authors.lastname: de Matos
authors.affiliation: Bioanalytical, Microfabrication, and Separations Group, Instituto de Química de São Carlos, Universidade de São Paulo São Carlos, Brazil.
authors.forename: Emanuel
authors.initials: E
authors.lastname: Carrilho
authors.affiliation: Laboratory of Parasitology, Department of Morphology and Pathology, Universidade Federal de São CarlosSão Carlos, Brazil; Bioanalytical, Microfabrication, and Separations Group, Instituto de Química de São Carlos, Universidade de São PauloSão Carlos, Brazil; Medical Parasitology Unit, Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de LisboaLisbon, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Afonso
authors.affiliation: Laboratory of Parasitology, Department of Morphology and Pathology, Universidade Federal de São Carlos São Carlos, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: de Freitas Anibal
keywords: IFN-γ; IL-5; cytokines; immune response; leukotriene; oral tolerance