title: The Effects of Intravenous Dexmedetomidine Injections on IOP in General Anesthesia Intubation: A Meta-Analysis.
abstract: Objective. The aim of this meta-analysis is to evaluate the effects of dexmedetomidine on intraocular pressure (IOP) in patients with general anesthesia administered via intubation.Methods. We searched randomized controlled trials (RCT) on the effects of intravenous injection of dexmedetomidine on IOP in patients with general anesthesia administered via intubation.Results. The meta-analysis study showed that (1) a statistically significant difference [WMD = -3.40 mmHg, 95% CI (-4.76, -2.04),P< 0.00001] was found between IOP of the two groups. (2) The IOP of the dexmedetomidine group that was administrated succinylcholine was lower than that of placebo group which was administrated succinylcholine [WMD = -4.13 mmHg, 95% CI (-6.01, -2.25),P< 0.0001]. (3) Compared with the IOP of patients in the placebo group, patients with intubation in the dexmedetomidine group maintained a lower IOP [WMD = -3.10 mmHg, 95% CI (-5.12, -1.07),P= 0.003]. However, for incidences of bradycardia, the use of dexmedetomidine was higher than that of the placebo [RR = 0.23, 95% CI (0.07, 0.76),P= 0.02].Conclusion. This meta-analysis showed that, in many cases, dexmedetomidine can lower the IOP of patients with general anesthesia administered by intubation.
authors.affiliation: Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China; Zhaoqing Medical College, Zhaoqing 526000, China.
authors.forename: Chengmao
authors.identifier: 0000-0001-5680-791X
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Zhaoqing Medical College, Zhaoqing 526000, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Lin
authors.identifier: 0000-0002-5226-3772
authors.initials: L
authors.lastname: Ruan
mesh_terms: D061605:Administration, Intravenous; D000768:Anesthesia, General / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D001919:Bradycardia / Q000188:drug therapy; D002318:Cardiovascular Diseases / Q000188:drug therapy; D020927:Dexmedetomidine / Q000008:administration & dosage*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007429:Intraocular Pressure / Q000187:drug effects*; D007442:Intubation, Intratracheal; D016032:Randomized Controlled Trials as Topic; D013390:Succinylcholine / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D013390:Succinylcholine