title: Electrospun water-stable zein/ethyl cellulose composite nanofiber and its drug release properties.
abstract: A simple and cost-effective way to prepare water-stable zein-based nanofibers for potential drug delivery was presented in this article. Corn protein zein was co-electrospun with hydrophobic ethyl cellulose. Indomethacin, as a model drug, was incorporated in situ into the composite nanofibers. Scanning electron microscopy and element mapping revealed the morphologies of drug-loaded nanofibers and drug distribution, respectively. Fourier transform infrared spectra confirmed the physical blending among the components. Differential scanning calorimetry and X-ray diffraction demonstrated the physical state of drug and polymers in the nanofiber matrix. The composite nanofibers showed a sustained diffusion-controlled release according to the results of in vitro dissolution tests.
authors.affiliation: Key Laboratory of Eco-textiles, Jiangnan University, Wuxi, People's Republic of China.
authors.forename: Hangyi
authors.initials: H
authors.lastname: Lu
authors.affiliation: Key Laboratory of Eco-textiles, Jiangnan University, Wuxi, People's Republic of China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Key Laboratory of Eco-textiles, Jiangnan University, Wuxi, People's Republic of China.
authors.forename: Guohui
authors.initials: G
authors.lastname: Li
authors.affiliation: Key Laboratory of Eco-textiles, Jiangnan University, Wuxi, People's Republic of China; Laboratory of Natural Medicine, Wuxi Medical School, Jiangnan University, People's Republic of China.
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Key Laboratory of Eco-textiles, Jiangnan University, Wuxi, People's Republic of China. Electronic address: qfwei@jiangnan.edu.cn.
authors.forename: Qufu
authors.initials: Q
authors.lastname: Wei
mesh_terms: D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004355:Drug Stability; D007213:Indomethacin / Q000737:chemistry* / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry; D017155:Wettability; D014961:X-Ray Diffraction; D015028:Zein / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D014867:Water; C013517:ethyl cellulose; D002482:Cellulose; D015028:Zein; D007213:Indomethacin
keywords: Drug release; Electrospinning; Ethyl cellulose; Water-stability; Zein