title: Blood transfusion indications in neurosurgical patients: A systematic review.
abstract: Neurosurgical procedures can be complicated by significant blood losses that have the potential to decrease tissue perfusion to critical brain tissue. Red blood cell transfusion is used in a variety of capacities both inside, and outside, of the operating room to prevent untoward neurologic damage. However, evidence-based guidelines concerning thresholds and indications for transfusion in neurosurgery remain limited. Consequently, transfusion practices in neurosurgical patients are highly variable and based on institutional experiences. Recently, a paradigm shift has occurred in neurocritical intensive care units, whereby restrictive transfusion is increasingly favored over liberal transfusion but the ideal strategy remains in clinical equipoise. The authors of this study perform a systematic review of the literature with the objective of capturing the changing landscape of blood transfusion indications in neurosurgical patients.
authors.affiliation: Departments of Neurosurgery, University of California, Los Angeles, United States.
authors.forename: Shefali
authors.initials: S
authors.lastname: Bagwe
authors.affiliation: Departments of Neurosurgery, University of California, Los Angeles, United States.
authors.forename: Lawrance K
authors.initials: LK
authors.lastname: Chung
authors.affiliation: Departments of Neurosurgery, University of California, Los Angeles, United States.
authors.forename: Carlito
authors.initials: C
authors.lastname: Lagman
authors.affiliation: Departments of Neurosurgery, University of California, Los Angeles, United States.
authors.forename: Brittany L
authors.initials: BL
authors.lastname: Voth
authors.affiliation: Departments of Neurosurgery, University of California, Los Angeles, United States.
authors.forename: Natalie E
authors.initials: NE
authors.lastname: Barnette
authors.affiliation: Departments of Neurosurgery, University of California, Los Angeles, United States.
authors.forename: Lekaa
authors.initials: L
authors.lastname: Elhajjmoussa
authors.affiliation: Departments of Neurosurgery, University of California, Los Angeles, United States; Radiation Oncology, University of California, Los Angeles, United States; Head and Neck Surgery, University of California, Los Angeles, United States; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, United States. Electronic address: iyang@mednet.ucla.edu.
authors.forename: Isaac
authors.initials: I
authors.lastname: Yang
mesh_terms: D001803:Blood Transfusion / Q000379:methods; D001921:Brain / Q000601:surgery*; D001930:Brain Injuries / Q000601:surgery*; D006801:Humans; D007362:Intensive Care Units; D009493:Neurosurgery / Q000379:methods; D019635:Neurosurgical Procedures
keywords: Blood transfusion; Cerebral neoplasm; Intracranial aneurysm; Neurosurgery; Subarachnoid hemorrhage; Traumatic brain injury