title: Aerobic Exercise Suppresses Atherosclerosis Through Adiponectin-Nuclear Transcription Factor κB Pathway in Apolipoprotein E-deficient Mice.
abstract: We aimed to investigate the therapeutic effect of aerobic exercise on atherosclerosis (AS) in apolipoprotein E-deficient mice and the adiponectin (ApN)-nuclear transcription factor κB (NF-κB) pathway involved in the related anti-inflammation.
  
  
  
  ApoE-deficient mice with AS (AS+C), and ApoE-deficient mice with AS and aerobic exercise (AS+E) were investigated for body weight and visceral fat. Pathomorphology of the aortic vascular wall was qualitatively and quantitatively evaluated with hematoxylin-eosin staining. The ApN messenger RNA level in adipose tissue and ApN level in plasma were determined. The aortic adiponectin receptor 1 (AdipoR1) and NF-κB levels were determined with western blot.
  
  
  
  There was no significant difference in body weight between the AS+C and the AS+E groups, but visceral fat in the AS+E group was significantly smaller than that in the AS+C group. Aortic vascular wall fiber board in the AS+C group broke, but this aortic disease in the AS+E group was obviously alleviated. The AS+E group showed a smaller neointimal hyperplasia and plaque area compared with AS+C group. After a high-fat diet, the ApN levels in both adipose tissue and plasma were decreased in the AS+C group and returned to a relative high level in the AS+E group. The expression of AdipoR1 protein in the AS+C group was significantly lower than those in the AS+E group. As for NF-κB protein, its enhanced expression in the AS+C group was reversed to a relatively low level in the AS+E group.
  
  
  
  Aerobic exercise suppressed AS through the ApN-NF-κB pathway in ApoE-deficient mice.
authors.affiliation: Department of Physical Education, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Human Kinetic Science, Hebei Institute of Physical Education, Shijiazhuang, Hebei, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Human Kinetic Science, Hebei Institute of Physical Education, Shijiazhuang, Hebei, China; College of Basic Medical, Hebei Medical University, Shijiazhuang, Hebei, China. Electronic address: jiaogf8@163.com.
authors.forename: Guangfa
authors.initials: G
authors.lastname: Jiao
authors.affiliation: Department of Physical Education, Henan Mechanical and Electrical Vocational College, Zhengzhou, Henan, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Yue
authors.affiliation: Department of Physical Education, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Wang
mesh_terms: D052242:Adiponectin / Q000032:analysis / Q000097:blood / Q000502:physiology*; D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D001011:Aorta / Q000473:pathology; D001057:Apolipoproteins E / Q000172:deficiency*; D050197:Atherosclerosis / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D008297:Male; D051379:Mice; D016328:NF-kappa B / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D054419:Receptors, Adiponectin / Q000032:analysis / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D052242:Adiponectin; D001057:Apolipoproteins E; D016328:NF-kappa B; D054419:Receptors, Adiponectin; C475419:adiponectin receptor 1, mouse
keywords: Adiponectin; Aerobic exercise; Apolipoprotein E–deficient mice; Atherosclerosis; Nuclear transcription factor κB