title: A nutritional supplement containing lactoferrin stimulates the immune system, extends lifespan, and reduces amyloidβpeptide toxicity inCaenorhabditis elegans.
abstract: Lactoferrin is a highly multifunctional glycoprotein involved in many physiological functions, including regulation of iron absorption and immune responses. Moreover, there is increasing evidence for neuroprotective effects of lactoferrin. We usedCaenorhabditis elegansas a model to test the protective effects, both on phenotype and transcriptome, of a nutraceutical product based on lactoferrin liposomes. In a dose-dependent manner, the lactoferrin-based product protected against acute oxidative stress and extended lifespan ofC. elegansN2. Furthermore, Paralysis of the transgenicC. elegansstrain CL4176, caused by Aβ1-42 aggregates, was clearly ameliorated by treatment. Transcriptome analysis in treated nematodes indicated immune system stimulation, together with enhancement of processes involved in the oxidative stress response. The lactoferrin-based product also improved the protein homeostasis processes, cellular adhesion processes, and neurogenesis in the nematode. In summary, the tested product exerts protection against aging and neurodegeneration, modulating processes involved in oxidative stress response, protein homeostasis, synaptic function, and xenobiotic metabolism. This lactoferrin-based product is also able to stimulate the immune system, as well as improving reproductive status and energy metabolism. These findings suggest that oral supplementation with this lactoferrin-based product could improve the immune system and antioxidant capacity. Further studies to understand the molecular mechanisms related with neuronal function would be of interest.
authors.affiliation: Cell Biology Laboratory Food Biotechnology Department Biópolis SL Paterna, Valencia 46980 Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Martorell
authors.affiliation: Cell Biology Laboratory Food Biotechnology Department Biópolis SL Paterna, Valencia 46980 Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Llopis
authors.affiliation: Cell Biology Laboratory Food Biotechnology Department Biópolis SL Paterna, Valencia 46980 Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Gonzalez
authors.affiliation: Cell Biology Laboratory Food Biotechnology Department Biópolis SL Paterna, Valencia 46980 Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ramón
authors.affiliation: Research and Development Department Sesderma Laboratories Rafelbuñol, Valencia 46138 Spain.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Serrano
authors.affiliation: Research and Development Department Sesderma Laboratories Rafelbuñol, Valencia 46138 Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Torrens
authors.affiliation: Research and Development Department Sesderma Laboratories Rafelbuñol, Valencia 46138 Spain.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Serrano
authors.affiliation: Research and Development Department Sesderma Laboratories Rafelbuñol, Valencia 46138 Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Navarro
authors.affiliation: Cell Biology Laboratory Food Biotechnology Department Biópolis SL Paterna, Valencia 46980 Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Genovés
keywords: Alzheimer's disease; Caenorhabditis elegans; immune system; lactoferrin; neuroprotection