title: [Indications and Clinical Implications of the Use of the Cardiac Markers BNP and NT-proBNP].
abstract: B-type natriuretic peptides are markers of myocardial wall stress. BNP or NT-proBNP are used for the differential diagnosis of acute dyspnoe where normal serum concentrations make a cardiac cause unlikely. New data show their importance for risk prediction in different stages of heart failure and in primary prevention. Natriuretic peptide guided therapy improves titration of heart failure medications. Compared to BNP, NT-proBNP is better suited during therapy with the new angiotensin-rezeptor-neprilysin-inhibitor Sacubitril/Valsartan. This review article summarizes current data on the importance of B-type natriuretic peptides for the interface of ambulatory and hospital care and presents recommendations for their practical use in patient care.
authors.affiliation: Klinik für Innere Medizin I (Kardiologie, Angiologie, Nephrologie, Pneumologie, Internistische Intensivmedizin), Klinikum St. Marien, Amberg.
authors.forename: Andreas
authors.initials: A
authors.lastname: Luchner
authors.affiliation: Klinik für Kardiologie und Pneumologie, Universitätsmedizin Göttingen, Georg-August-Universität Göttingen, Göttingen.
authors.forename: Stephan
authors.initials: S
authors.lastname: von Haehling
authors.affiliation: Park-Klinikum, Bad Krozingen.
authors.forename: Christian
authors.initials: C
authors.lastname: Holubarsch
authors.affiliation: Goethe University Frankfurt, Department of Internal Medicine III, Division of Cardiology, Frankfurt am Main.
authors.forename: Till
authors.initials: T
authors.lastname: Keller
authors.affiliation: Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Campus Mitte, Charité - Universitätsmedizin Berlin.
authors.forename: Fabian
authors.initials: F
authors.lastname: Knebel
authors.affiliation: Internistische Gemeinschaftspraxis Steiner Thor, Straubing.
authors.forename: Christian
authors.initials: C
authors.lastname: Zugck
authors.affiliation: Klinik für Innere Medizin III, Kardiologie, Angiologie und internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Laufs
mesh_terms: D015415:Biomarkers / Q000097:blood; D004417:Dyspnea / Q000097:blood* / Q000175:diagnosis*; D019317:Evidence-Based Medicine; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain