title: Automated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiograms.
abstract: To compare the lesion sizes of choroidal neovascularization (CNV) imaged with spectral-domain (SD) and swept-source (SS) optical coherence tomography angiography (OCTA) and measured using an automated detection algorithm.
  
  
  
  Patients diagnosed with CNV were imaged by SD-OCTA and SS-OCTA systems using 3 × 3-mm and 6 × 6-mm scans. The complex optical microangiography (OMAGC) algorithm was used to generate the OCTA images. Optical coherence tomography A datasets for imaging CNV were derived by segmenting from the outer retina to 8 μm below Bruch's membrane. An artifact removal algorithm was used to generate angiograms free of retinal vessel projection artifacts. An automated detection algorithm was developed to quantify the size of the CNV. Automated measurements were compared with manual measurements. Measurements from SD-OCTA and SS-OCTA instruments were compared as well.
  
  
  
  Twenty-seven eyes from 23 subjects diagnosed with CNV were analyzed. No significant differences were detected between manual and automatic measurements: SD-OCTA 3 × 3-mm (P = 0.61, paired t-test) and 6 × 6-mm (P = 0.09, paired t-test) scans and the SS-OCTA 3 × 3-mm (P = 0.41, paired t-test) and 6 × 6-mm (P = 0.16, paired t-test) scans. Bland-Altman analyses were performed to confirm the agreement between automatic and manual measurements. Mean lesion sizes were significantly larger for the SS-OCTA images compared with the SD-OCTA images: 3 × 3-mm scans (P = 0.011, paired sample t-test) and the 6 × 6-mm scans (P = 0.021, paired t-test).
  
  
  
  The automated algorithm measurements of CNV were in agreement with the hand-drawn measurements. On average, automated SS-OCTA measurements were larger than SD-OCTA measurements and consistent with the results from using hand-drawn measurements.
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington, United States.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington, United States.
authors.forename: Chieh-Li
authors.initials: CL
authors.lastname: Chen
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington, United States.
authors.forename: Zhongdi
authors.initials: Z
authors.lastname: Chu
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Fang
authors.initials: F
authors.lastname: Zheng
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Andrew
authors.initials: A
authors.lastname: Miller
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington, United States 3Department of Ophthalmology, Federal University of São Paulo, Sao Paulo, Brazil.
authors.forename: Luiz
authors.initials: L
authors.lastname: Roisman
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Joao
authors.initials: J
authors.lastname: Rafael de Oliveira Dias
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Zohar
authors.initials: Z
authors.lastname: Yehoshua
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Karen B
authors.initials: KB
authors.lastname: Schaal
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: William
authors.initials: W
authors.lastname: Feuer
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gregori
authors.affiliation: Advanced Development, Carl Zeiss Meditec, Inc., Dublin, California, United States.
authors.forename: Sophie
authors.initials: S
authors.lastname: Kubach
authors.affiliation: Advanced Development, Carl Zeiss Meditec, Inc., Dublin, California, United States.
authors.forename: Lin
authors.initials: L
authors.lastname: An
authors.affiliation: Advanced Development, Carl Zeiss Meditec, Inc., Dublin, California, United States.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Stetson
authors.affiliation: Advanced Development, Carl Zeiss Meditec, Inc., Dublin, California, United States.
authors.forename: Mary K
authors.initials: MK
authors.lastname: Durbin
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenfeld
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington, United States 5Department of Ophthalmology, University of Washington, Seattle, Washington, United States.
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001331:Automation; D002829:Choroid / Q000098:blood supply* / Q000473:pathology; D020256:Choroidal Neovascularization / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000379:methods*