title: New Cytotoxic Seco-Type Triterpene and Labdane-Type Diterpenes from Nuxia oppositifolia.
abstract: Chromatographic purification of then-hexane and dichloromethane extracts ofNuxia oppositifoliaaerial parts, growing in Saudi Arabia, resulted in the isolation and characterization of three new labdane-type diterpene acids, 2β-acetoxy-labda-7-en-15-oic acid (1), 2β-acetoxy-7-oxolabda-8-en-15-oic acid (2), 2β-acetoxy-6-oxolabda-7-en-15-oic acid (3), and one new seco-triterpene, 3,4-seco olean-12-en-3,30 dioic acid (4), together with 10 known lupane, oleanane and ursane-type triterpenes, as well as the common phytosterols, β-sitosterol and stigmasterol (5-16). Their structures have been assigned on the basis of different spectroscopic techniques including 1D and 2D NMR. Moreover, 13 of the isolated compounds were tested on the human cancer cell lines HeLa (cervical), A549 (lung) and MDA (breast), and most of the compounds showed potent cytotoxic activities in vitro.
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. salmassarani@ksu.edu.sa.
authors.forename: Shaza M
authors.initials: SM
authors.lastname: Al-Massarani
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. aelgamel@ksu.edu.sa.|Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, El-Mansoura 35516, Egypt. aelgamel@ksu.edu.sa.
authors.forename: Ali A
authors.initials: AA
authors.lastname: El-Gamal
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. khalid_parvez@yahoo.com.
authors.forename: Mohammad K
authors.initials: MK
authors.lastname: Parvez
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. mdosari@ksu.edu.sa.
authors.forename: Mohammed S
authors.initials: MS
authors.lastname: Al-Dosari
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. msalsaid@ksu.edu.sa.
authors.forename: Mansour S
authors.initials: MS
authors.lastname: Al-Said
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-kharj 11942, Saudi Arabia. m.youssef@psau.edu.sa.|Department of Pharmacognosy, College of Pharmacy, Alexandria University, Alexandria 21215, Egypt. m.youssef@psau.edu.sa.
authors.forename: Maged S
authors.initials: MS
authors.lastname: Abdel-Kader
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. basudan@ksu.edu.sa.
authors.forename: Omer A
authors.initials: OA
authors.lastname: Basudan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D064209:Phytochemicals; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D064028:Tracheophyta / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D064209:Phytochemicals; D010936:Plant Extracts; D014315:Triterpenes
keywords: Nuxia oppositifolia; cytotoxicity; labdane-type diterpene; seco-triterpene; triterpenes