title: Regional homogeneity, resting-state functional connectivity and amplitude of low frequency fluctuation associated with creativity measured by divergent thinking in a sex-specific manner.
abstract: Brain connectivity is traditionally thought to be important for creativity. Here we investigated the associations of creativity measured by divergent thinking (CMDT) with resting-state functional magnetic imaging (fMRI) measures and their sex differences. We examined these relationships in the brains of 1277 healthy young adults. Whole-brain analyses revealed a significant interaction between verbal CMDT and sex on (a) regional homogeneity within an area from the left anterior temporal lobe (b) on the resting state functional connectivity (RSFC) between the mPFC and the left inferior frontal gyrus and (c) on fractional amplitude of low frequency fluctuations (fALFF) in several distinct areas, including the precuneus and middle cingulate gyrus, left middle temporal gyrus, right middle frontal gyrus, and cerebellum. These interactions were mediated by positive correlations in females and negative correlations in males. These findings suggest that greater CMDT in females is reflected by (a) regional coherence (regional homogeneity) of brain areas responsible for representing and combining concepts as well as (b) the efficient functional connection (RSFC) between the key areas for the default state of cognitive activity and speech production, and (c) greater spontaneous neural activity (fALFF) during the resting of brain areas involved in frontal lobe functions, default cognitive activities, and language functions. Furthermore, these findings suggest that the associations between creativity and resting state brain connectivity patterns are different between males and females.
authors.affiliation: Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. Electronic address: takehi@idac.tohoku.ac.jp.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Takeuchi
authors.affiliation: Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Department of Radiology and Nuclear Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Taki
authors.affiliation: Creative Interdisciplinary Research Division, Frontier Research Institute for Interdisciplinary Science, Tohoku University, Sendai, Japan; Human and Social Response Research Division, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan; Smart Ageing International Research Center, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Rui
authors.initials: R
authors.lastname: Nouchi
authors.affiliation: School of Medicine, Kobe University, Kobe, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Yokoyama
authors.affiliation: Division of Clinical research, Medical-Industry Translational Research Center, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kotozaki
authors.affiliation: Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; Department of Psychiatry, Tohoku Pharmaceutical University, Sendai, Japan.
authors.forename: Seishu
authors.initials: S
authors.lastname: Nakagawa
authors.affiliation: Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sekiguchi
authors.affiliation: Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Kunio
authors.initials: K
authors.lastname: Iizuka
authors.affiliation: Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Sugiko
authors.initials: S
authors.lastname: Hanawa
authors.affiliation: Smart Ageing International Research Center, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Araki
authors.affiliation: Graduate School of Arts and Sciences, Department of General Systems Studies, The University of Tokyo, Tokyo, Japan.
authors.forename: Carlos
authors.initials: C
authors.lastname: Makoto Miyauchi
authors.affiliation: Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Shinada
authors.affiliation: Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Sakaki
authors.affiliation: Department of Ubiquitous Sensing, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nozawa
authors.affiliation: Department of Ubiquitous Sensing, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Ikeda
authors.affiliation: Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Yokota
authors.affiliation: School of Electronic, Electrical and Systems Engineering, Loughborough University, England, UK.
authors.forename: Magistro
authors.initials: M
authors.lastname: Daniele
authors.affiliation: Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sassa
authors.affiliation: Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; Smart Ageing International Research Center, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Kawashima
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D003405:Creativity; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011581:Psychological Tests; D012727:Sex Characteristics; D055815:Young Adult
keywords: Anterior temporal lobe; Creativity; Divergent thinking; Functional connectivity; Regional coherence; Resting state; Sex difference