title: Mechanisms of circumferential gyral convolution in primate brains.
abstract: Mammalian cerebral cortices are characterized by elaborate convolutions. Radial convolutions exhibit homology across primate species and generally are easily identified in individuals of the same species. In contrast, circumferential convolutions vary across species as well as individuals of the same species. However, systematic study of circumferential convolution patterns is lacking. To address this issue, we utilized structural MRI (sMRI) and diffusion MRI (dMRI) data from primate brains. We quantified cortical thickness and circumferential convolutions on gyral banks in relation to axonal pathways and density along the gray matter/white matter boundaries. Based on these observations, we performed a series of computational simulations. Results demonstrated that the interplay of heterogeneous cortex growth and mechanical forces along axons plays a vital role in the regulation of circumferential convolutions. In contrast, gyral geometry controls the complexity of circumferential convolutions. These findings offer insight into the mystery of circumferential convolutions in primate brains.
authors.affiliation: School of Automation and Brain Decoding Research Center, Northwestern Polytechnical University, Xi'an, China.|Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, GA, USA.
authors.forename: Tuo
authors.initials: T
authors.lastname: Zhang
authors.affiliation: College of Engineering, The University of Georgia, Athens, GA, USA.
authors.forename: Mir Jalil
authors.initials: MJ
authors.lastname: Razavi
authors.affiliation: Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, GA, USA.
authors.forename: Hanbo
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, GA, USA.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Automation and Brain Decoding Research Center, Northwestern Polytechnical University, Xi'an, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.affiliation: Biomedical Imaging Technology Center, Emory University, Atlanta, GA, USA.
authors.forename: Longchuan
authors.initials: L
authors.lastname: Li
authors.affiliation: School of Automation and Brain Decoding Research Center, Northwestern Polytechnical University, Xi'an, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.affiliation: Biomedical Imaging Technology Center, Emory University, Atlanta, GA, USA.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, GA, USA. tliu@uga.edu.
authors.forename: Tianming
authors.initials: T
authors.lastname: Liu
authors.affiliation: College of Engineering, The University of Georgia, Athens, GA, USA. xqwang@uga.edu.
authors.forename: Xianqiao
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D001921:Brain; D001931:Brain Mapping; D002540:Cerebral Cortex; D006801:Humans; D008959:Models, Neurological; D011323:Primates
keywords: Axon; Computational modeling; Gyral convolution; Heterogeneous growth; MRI