title: The Expression of B7-H3 in Circulating CD4+CD25high T Cells, Circulating CD14+ Monocytes and Plasma during Hepatitis B Virus Infection Progression.
abstract: BACKGROUND
  B7-H3 is frequently upregulated in response to autoantigens and pathogens during host T cell immune responses. However, the role of B7-H3 which express in CD14+ monocytes and CD4+CD25high T cells had not been investigated.
  
  
  METHODS
  Cytometry and ELISA were used in this study.
  
  
  RESULTS
  The study showed that B7-H3 expression in CD14+ monocytes, CD4+CD25high T cells, and plasma was significantly increased in AHB, CHB, HBV-LC, and HBV-HCC group. In CHB group, the expression of B7-H3 was positively correlated with the ALT and AST levels.
  
  
  CONCLUSIONS
  B7-H3 expression in peripheral CD14+ monocytes, CD4+CD25high T cells, and plasma changed with HBV infection progression and had a significant correlation with liver function in CHB. B7-H3 expression could be utilized as a potential clinical indicator to determine the extent of liver injury.
authors.forename: Jun-Chi
authors.initials: JC
authors.lastname: Xu
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ma
authors.forename: Cui-Lin
authors.initials: CL
authors.lastname: Shi
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhu
authors.forename: Hua-Feng
authors.initials: HF
authors.lastname: Song
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Chuan-Wu
authors.initials: CW
authors.lastname: Zhu
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
mesh_terms: D015496:CD4-Positive T-Lymphocytes; D018450:Disease Progression; D006509:Hepatitis B; D019694:Hepatitis B, Chronic; D006801:Humans; D009000:Monocytes