title: Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate.
abstract: Nanoporous lithium doping magnesium silicate (nl-MS) was introduced into calcium sulfate hemihydrate to prepare calcium sulfate composite (nl-MSC) bone cements. The introduction of nl-MS improved the in vitro degradability of nl-MSC cements, which could neutralize acidic degradable products of calcium sulfate and prevented the pH from dropping. The cements were implanted into the bone defects of femur bone of rabbits, and the results of histological and immunohistochemical analysis revealed that massive new bone tissue formed in the defects while the cements were degradable, indicating that the osteogenesis and degradability of the nl-MSC cements were much better than the control calcium sulfate dihydrate (CSD) cements. Furthermore, the positive expression of vascular endothelial growth factor and collagen type I for nl-MSC cements was higher than CSD, indicating that addition of nl-MS into the cements enhanced vascularization and osteogenic differentiation. The results suggested that the nl-MSC cements with good biocompatibility and degradability could promote vascularization and osteogenesis, and had great potential to treat bone defects.
authors.affiliation: Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Liehu
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Weizong
authors.initials: W
authors.lastname: Weng
authors.affiliation: Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Qirong
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Jin
authors.initials: J
authors.lastname: Cui
authors.affiliation: Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Yuechao
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Biomedical Engineering, Inje University, Gimhae, Republic of Korea.
authors.forename: Jung-Woog
authors.initials: JW
authors.lastname: Shin
authors.affiliation: Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Jiacan
authors.initials: J
authors.lastname: Su
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects*; D002133:Calcium Sulfate / Q000737:chemistry*; D002454:Cell Differentiation / Q000187:drug effects; D005260:Female; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D007124:Immunoenzyme Techniques; D008094:Lithium / Q000737:chemistry*; D017633:Magnesium Silicates / Q000737:chemistry*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects*; D011817:Rabbits; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D001843:Bone Cements; D017633:Magnesium Silicates; D042461:Vascular Endothelial Growth Factor A; D008094:Lithium; D002133:Calcium Sulfate
keywords: bone cements; degradability; nanoporous lithium doping magnesium silicate; osteogenesis; vascularization