title: [Expression and correlation of survivin and hsa-miR-542-3p in patients with oral squamous cell carcinoma].
abstract: OBJECTIVE
  To detect the expression of survivin and hsa-miR-542-3p in patients with oral squamous cell carcinoma (OSCC) and explore their correlation with clinicopathologic parameters.
  
  
  METHODS
  Protein levels of survivin and hsa-miR-542-3p were measured in 30 OSCC patients and SCC-15 cell line. Plasma hsa-miR-542-3p level was analyzed in 30 OSCC patients and 30 normal controls. Statistical analysis was performed with SPSS 17.0 software package.
  
  
  RESULTS
  In OSCC samples, survivin was increased while hsa-miR-542-3p was decreased. There was a negative correlation between survivin and hsa-miR-542-3p. In SCC-15 cell line, inhibitor and mimic of hsa-miR-542-3p could regulate survivin expression. Plasma level of hsa-miR-542-3p was decreased in OSCC patients. The potential diagnostic performance of plasma hsa-miR-542-3p for OSCC patients was evaluated by ROC curve analysis and AUC was 0.82.
  
  
  CONCLUSIONS
  Down-regulation of hsa-miR-542-3p correlates with increasing of survivin expression in OSCC. Plasma hsa-miR-542-3p is a potential diagnostic biomarker for OSCC.
authors.affiliation: Department of Stomatology, Shanghai Seventh People's Hospital. Shanghai 200137,China. E-mail:13361951308@163.com.
authors.forename: Ning
authors.initials: N
authors.lastname: Wu
authors.forename: Ying
authors.initials: Y
authors.lastname: Lu
authors.forename: Ji-Zong
authors.initials: JZ
authors.lastname: Liang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D015536:Down-Regulation; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D035683:MicroRNAs; D009062:Mouth Neoplasms / Q000378:metabolism*; D014162:Transfection
chemical_list: D051034:Inhibitor of Apoptosis Proteins; C572357:MIRN542 microRNA, human; D035683:MicroRNAs