title: Spirooxindole synthesis via palladium-catalyzed dearomative reductive-Heck reaction.
abstract: Palladium-catalyzed intramolecular dearomative reductive-Heck reaction of C2-substituted indoles is developed, which provides access to structurally diverse 3,2'-spiropyrrolidine oxindoles. By changing the hydride source to AcONa base, direct C3-arylation products [2,3-b]quinolinones are achieved in good yields. The reaction of C2-substituted benzofuran is also realized, delivering the desired spiro-product.
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. yxjia@zjut.edu.cn.
authors.forename: Ren-Rong
authors.initials: RR
authors.lastname: Liu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. yxjia@zjut.edu.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. yxjia@zjut.edu.cn.
authors.forename: Ren-Xiao
authors.initials: RX
authors.lastname: Liang
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. yxjia@zjut.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Xiang
authors.affiliation: Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310035, China.
authors.forename: Hu-Jun
authors.initials: HJ
authors.lastname: Xie
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. yxjia@zjut.edu.cn.
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Gao
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. yxjia@zjut.edu.cn.
authors.forename: Yi-Xia
authors.identifier: http://orcid.org/0000-0001-7936-0049
authors.initials: YX
authors.lastname: Jia