title: Unsweetened IgG Is Bad for Dengue Patients.
abstract: Dengue hemorrhagic fever is shown to correlate with secondary infection with a virus serotype different from the previous infection. However, only a small fraction of secondary infections leads to hemorrhagic fever. A recent Science paper suggests that the fucosylation state and isotype of IgGs elicited in patients may enhance disease severity.
authors.affiliation: Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore. Electronic address: sheemei.lok@duke-nus.edu.sg.
authors.forename: Shee-Mei
authors.initials: SM
authors.lastname: Lok
mesh_terms: D000914:Antibodies, Viral; D060085:Coinfection; D003715:Dengue / Q000821:virology*; D003716:Dengue Virus / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G; D019595:Severe Dengue / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G
keywords: IgG; dengue; dengue hemorrhagic fever; enhancement of disease; fucosylation of IgG; platelet depletion