title: Should I Stay or Should I Go: A Clash of α-Cell Identity.
abstract: Understanding mechanisms for maintaining pancreatic islet cell fate and function is important for addressing the urgent challenge of restoring islet β- and α-cell function in T1DM. In this issue of Cell Metabolism, Chakravarthy et al. (2017) identify a genetic mechanism by which mouse β-cells are spontaneously regenerated from adult α-cells.
authors.affiliation: Department of Medicine, Division of Endocrinology, Metabolism and Lipid Research, School of Medicine, Washington University in Saint Louis, Saint Louis, MO 63110, USA. Electronic address: mremedi@wustl.edu.
authors.forename: Maria S
authors.initials: MS
authors.lastname: Remedi
mesh_terms: D000818:Animals; D050416:Glucagon-Secreting Cells; D050417:Insulin-Secreting Cells; D007515:Islets of Langerhans