title: Water Solubilization of Fullerene Derivatives by β-(1,3-1,6)-d-Glucan and Their Photodynamic Activities toward Macrophages.
abstract: Anionic and neutral fullerene derivatives were dissolved in water by using β-(1,3-1,6)-d-glucan (β-1,3-glucan) as a solubilizing agent. In the water-solubilized complexes, the concentrations of fullerene derivatives were ≈0.30 mm and the average particle sizes were ≈90 nm. The β-1,3-glucan-complexed fullerene derivative with a carboxylic acid was found to have higher photodynamic activity toward macrophages under visible-light irradiation (λ>610 nm) than other β-1,3-glucan-complexed fullerene derivatives. This result suggests that carboxylic acid moieties in the complex enhance the binding affinity with β-1,3-glucan receptors on the surface of macrophages when the β-1,3-glucan is recognized. In contrast, all β-1,3-glucan-complexed fullerene derivatives showed no photodynamic activity toward HeLa cells under the same conditions.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima, 739-8527, Japan.
authors.forename: Atsushi
authors.identifier: http://orcid.org/0000-0003-3492-3455
authors.initials: A
authors.lastname: Ikeda
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Iizuka
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan.
authors.forename: Naotake
authors.initials: N
authors.lastname: Maekubo
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Nobusawa
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima, 739-8527, Japan.
authors.forename: Kouta
authors.initials: K
authors.lastname: Sugikawa
authors.affiliation: Department of Nanobiochemistry, Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-Minamimachi, Kobe, 650-0047, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Koumoto
authors.affiliation: Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka, 558-8585, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka, 558-8585, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagasaki
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo, 113-8551, Japan.
authors.forename: Motofusa
authors.initials: M
authors.lastname: Akiyama
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D037741:Fullerenes / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D010316:Particle Size; D010778:Photochemotherapy; D000067996:RAW 264.7 Cells; D012995:Solubility; D013329:Structure-Activity Relationship; D013499:Surface Properties; D014867:Water / Q000737:chemistry*; D047071:beta-Glucans / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D037741:Fullerenes; D047071:beta-Glucans; D014867:Water
keywords: Fullerenes; host-guest systems; macrophages; medicinal chemistry; polysaccharides