title: Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort.
abstract: To characterize actual achieved patterns of oxygenation in infants born appropriate vs small for gestational age (SGA) randomized to a lower (85-89%) vs higher (91%-95%) oxygen saturation target in the Surfactant Positive Pressure and Oxygen Trial. To determine the association between achieved oxygen saturation levels and survival in infants born appropriate vs SGA enrolled in the Surfactant Positive Pressure and Oxygen Trial.
  
  
  
  Median oxygen saturation and intermittent hypoxemia events (<80%, 20 seconds-5  minutes) were documented in 1054 infants of 240/7-276/7weeks of gestation while receiving supplemental oxygen during the first 3 days of life.
  
  
  
  Lower target infants who were small for gestational age had the lowest oxygen saturation and highest incidence of intermittent hypoxemia during the first 3 days of life. The lowest quartile of oxygen saturation (≤92%) during the first 3 days of life was associated with lower 90-day survival for both infants born appropriate and SGA. An increased incidence of intermittent hypoxemia events during the first 3 days of life was associated with lower 90-day survival only in infants born SGA.
  
  
  
  Lower achieved oxygen saturation during the first 3 days of life was associated with lower 90-day survival in extremely preterm infants. Infants born SGA had enhanced vulnerability to lower oxygen saturation targets as evidenced by lower achieved oxygen saturation and an association between increased intermittent hypoxemia events and lower survival.
  
  
  
  ClinicalTrials.gov: NCT00233324.
authors.affiliation: Division of Neonatology, Rainbow Babies & Children's Hospital, Department of Pediatrics, Case Western Reserve University, Cleveland, OH. Electronic address: jmd3@case.edu.
authors.forename: Juliann M
authors.initials: JM
authors.lastname: Di Fiore
authors.affiliation: Division of Neonatology, Rainbow Babies & Children's Hospital, Department of Pediatrics, Case Western Reserve University, Cleveland, OH.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Martin
authors.affiliation: Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, OH.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, OH.
authors.forename: Nathan
authors.initials: N
authors.lastname: Morris
authors.affiliation: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
authors.forename: Waldemar A
authors.initials: WA
authors.lastname: Carlo
authors.affiliation: Department of Pediatrics, University of California, San Diego, CA.
authors.forename: Neil
authors.initials: N
authors.lastname: Finer
authors.affiliation: Division of Neonatology, Rainbow Babies & Children's Hospital, Department of Pediatrics, Case Western Reserve University, Cleveland, OH.
authors.forename: Michele
authors.initials: M
authors.lastname: Walsh
mesh_terms: D015331:Cohort Studies; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000378:metabolism* / Q000401:mortality / Q000628:therapy*; D007236:Infant, Small for Gestational Age; D008297:Male; D010102:Oxygen Inhalation Therapy; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D015996:Survival Rate
chemical_list: D011663:Pulmonary Surfactants
keywords: hypoxia; intermittent hypoxemia; oxygen saturation; small for gestational age; supplemental oxygen