title: Silver-promoted (radio)fluorination of unsaturated carbamates via a radical process.
abstract: The intramolecular fluorocyclization of unsaturated carbamates is described here using a hypervalent iodine reagent in the presence of a silver catalyst. Both (hetero)aryl-substituted olefins and acrylamides can be utilized as effective substrates. Preliminary mechanistic investigations suggest that the reaction proceeds via a cyclization/1,2-(hetero)aryl migration/fluorination cascade involving an unusual radical process. Furthermore, starting from no-carrier-added [18F]TBAF, a simple one-pot, two-step cascade method was developed for the generation of18F-labeled heterocycles with high radiochemical purity.
authors.affiliation: Institute of Chemistry & BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. hongjianlu@nju.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Kantapat
authors.initials: K
authors.lastname: Chansaenpak
authors.forename: Hongmiao
authors.initials: H
authors.lastname: Wu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Mengzhe
authors.initials: M
authors.lastname: Wang
authors.forename: Zibo
authors.initials: Z
authors.lastname: Li
authors.forename: Hongjian
authors.initials: H
authors.lastname: Lu