title: Iron acquisition through the bacterial transferrin receptor.
abstract: Transferrin is one of the sources of iron that is most readily available to colonizing and invading pathogens. In this review, we look at iron uptake by the bacterial transferrin receptor that is found in the families Neisseriaceae, Pasteurellaceae and Moraxellaceae. This bipartite receptor consists of the TonB-dependent transporter, TbpA, and the surface lipoprotein, TbpB. In the past three decades, major advancements have been made in our understanding of the mechanism through which the Tbps take up iron. We summarize these findings and discuss how they relate to the diversity and specificity of the transferrin receptor. We also outline several of the remaining unanswered questions about iron uptake via the bacterial transferrin receptor and suggest directions for future research.
authors.affiliation: a Department of Biochemistry , University of Toronto , Toronto , Canada.
authors.forename: Anastassia K
authors.initials: AK
authors.lastname: Pogoutse
authors.affiliation: a Department of Biochemistry , University of Toronto , Toronto , Canada.
authors.forename: Trevor F
authors.initials: TF
authors.lastname: Moraes
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000235:genetics / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D033881:Transferrin-Binding Protein A / Q000235:genetics / Q000378:metabolism*; D033882:Transferrin-Binding Protein B / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; D033881:Transferrin-Binding Protein A; D033882:Transferrin-Binding Protein B; C057616:tonB protein, Bacteria; D007501:Iron
keywords: TonB-dependent transporter; Transferrin; bacterial iron uptake; outer membrane protein; surface lipoprotein; virulence factor