title: Transcriptional and epigenetic regulation of follicular T-helper cells and their role in autoimmunity.
abstract: T-follicular helper (Tfh) cells are a specialized subset of T cells that provide help to B cells and promote the formation of germinal centers (GCs). Tfh cells transmit important signals to B cells that drive class switch recombination, somatic hyper-mutation, the generation of high-affinity antibodies, immunological memory and their differentiation into plasma cells or memory B cells in the GCs. Tfh-cell differentiation is regulated by the coordinated functions of distinct cytokines, including interleukin (IL)-6, IL-21, IL-12, IL-23, IL-2, IL-7 and transforming growth factor-β (TGF-β), as well as transcription factors, including B-cell lymphoma 6 protein (Bcl-6), Signal transducers and activators of transcription (STAT)1, STAT3, STAT4, B-cell activating transcription factor (Batf), interferon regulatory factor 4 (IRF4), v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog (C-Maf), T-cell-specific transcription factor 1 (TCF-1) and Achaete-scute homolog 2 (Acl2), which have been shown to form a complex transcriptional network. In addition, increasing evidence indicates that epigenetic regulations, such as DNA methylation, histone modifications and non-coding RNA regulations, also coordinately control the differentiation and function of Tfh cells along with transcription factors. Furthermore, abnormalities in the regulation of Tfh cells have been associated with several autoimmune diseases, such as systemic lupus erythematosus (SLE), multiple sclerosis (MS) and rheumatoid arthritis (RA). Herein, this review aims to summarize the coordinate regulation and interaction of transcription factors, cytokines and epigenetic modifications that control Tfh-cell differentiation as well as the mechanism of dysregulation of Tfh cells in pathogenesis of autoimmune diseases, which highlight potential therapeutic targets.
authors.affiliation: a Department of Dermatology , Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics , Changsha , China and.
authors.forename: Hong
authors.initials: H
authors.lastname: Qiu
authors.affiliation: a Department of Dermatology , Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics , Changsha , China and.
authors.forename: Haijing
authors.initials: H
authors.lastname: Wu
authors.affiliation: b Division of Rheumatology & Clinical Immunology , Department of Medicine, University of Hong Kong , Hong Kong.
authors.forename: Vera
authors.initials: V
authors.lastname: Chan
authors.affiliation: b Division of Rheumatology & Clinical Immunology , Department of Medicine, University of Hong Kong , Hong Kong.
authors.forename: Chak-Sing
authors.initials: CS
authors.lastname: Lau
authors.affiliation: a Department of Dermatology , Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics , Changsha , China and.
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Lu
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015551:Autoimmunity / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006657:Histones / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D058990:Molecular Targeted Therapy; D011485:Protein Binding; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D006657:Histones; D035683:MicroRNAs; D014157:Transcription Factors
keywords: DNA methylation; T-follicular helper; autoimmunity; histone modifications; microRNAs; transcription factor