title: High coronary calcium score and post-procedural CK-MB are noninvasive predictors of coronary stent restenosis.
abstract: OBJECTIVE
  High coronary calcium score (CCS) and post-procedural cardiac enzyme may be related with poor outcomes in patients with coronary stent implantation.
  
  
  METHODS
  A total of 1,072 patients (63.2% male, mean age: 61.7±10.3 years) who underwent coronary multi-detect computed tomography at index procedure and follow-up coronary angiography (CAG) after drug-eluting stent (DES) were divided into two groups: those with and without target lesion revascularization (TLR; >50% reduction in luminal stent diameter or angina symptoms on follow-up CAG). The CCSs for predicting stent revascularization were elucidated.
  
  
  RESULTS
  There were no significant differences between the two groups with regard to risk factors. The initial CCS was significantly higher in the TLR group (1,102.4±743.7 vs 345.8±51.05,P=0.04). After adjustment of significant factors for TLR, only CCS and post-procedural creatine kinase MB form (CK-MB) elevation were significant predictors of coronary artery TLR. Receiver operation curve revealed that >800 in CCS had 69% in sensitivity and 88% in specificity about predicting the TLR.
  
  
  CONCLUSIONS
  High CCS with post-procedural CK-MB might be the useful predictors for TLR after DES implantation.
authors.affiliation: Anyang Sam Hospital.
authors.forename: Jae-Beom
authors.initials: JB
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Youido St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Yun-Seok
authors.initials: YS
authors.lastname: Choi
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Youido St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Woo-Baek
authors.initials: WB
authors.lastname: Chung
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Youido St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Ami
authors.initials: A
authors.lastname: Kwon
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Youido St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Chul-Soo
authors.initials: CS
authors.lastname: Park
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Youido St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Man-Young
authors.initials: MY
authors.lastname: Lee
mesh_terms: D000368:Aged; D002118:Calcium / Q000097:blood*; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000097:blood*; D052279:Creatine Kinase, MB Form / Q000097:blood*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D052279:Creatine Kinase, MB Form; D002118:Calcium
keywords: calcium; coronary restenosis; creatine kinase; drug-eluting stents