title: Chemical and bioactivity of flavanones obtained from roots of Dalea pazensis Rusby.
abstract: Two new prenylated flavanones, pazentin A (3',4'-dihydroxy-6,2'-diprenylpinocembrin, 1) and pazentin B [4'-hydroxy-2'-methoxy-5'-(1‴, 1‴-dimethylallyl)-6-prenylpinocembrin, 2] together with two known ones (3 and 4) previously isolated from other Dalea species were obtained from the benzene extract of Dalea pazensis Rusby roots. The compounds were evaluated in vitro for their inhibition on mushroom tyrosinase enzyme and in relation to their effect on melanogenesis in B16 murine melanoma cells, by using a spectrophotometric method. The information obtained could be relevant to the knowledge of the structure-activity relationship for these flavonoids with the aim to explore the rational design for skin-whitening agents.
authors.affiliation: Farmacognosia, Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Haya de la torre y Medina Allende, Edificio Ciencias II, X5000HUA Córdoba, Argentina; Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Ciudad Universitaria, X5000HUA Córdoba, Argentina.
authors.forename: María D
authors.initials: MD
authors.lastname: Santi
authors.affiliation: Farmacognosia, Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Haya de la torre y Medina Allende, Edificio Ciencias II, X5000HUA Córdoba, Argentina; Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Ciudad Universitaria, X5000HUA Córdoba, Argentina.
authors.forename: Mariana A
authors.initials: MA
authors.lastname: Peralta
authors.affiliation: Departamento de Farmacia, Facultad de Ciencias Químico-Farmacéuticas y Bioquímicas, Universidad de San Francisco Xavier de Chuquisaca, Sucre, Bolivia.
authors.forename: Caterine S
authors.initials: CS
authors.lastname: Mendoza
authors.affiliation: Farmacognosia, Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Haya de la torre y Medina Allende, Edificio Ciencias II, X5000HUA Córdoba, Argentina; Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Ciudad Universitaria, X5000HUA Córdoba, Argentina. Electronic address: jcabrera@fcq.unc.edu.ar.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Cabrera
authors.affiliation: Farmacognosia, Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Haya de la torre y Medina Allende, Edificio Ciencias II, X5000HUA Córdoba, Argentina; Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Ciudad Universitaria, X5000HUA Córdoba, Argentina. Electronic address: gortega@fcq.unc.edu.ar.
authors.forename: María G
authors.initials: MG
authors.lastname: Ortega
mesh_terms: D000363:Agaricales / Q000201:enzymology*; D000818:Animals; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry* / Q000494:pharmacology*; D008543:Melanins / Q000378:metabolism*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry; D054876:Prenylation
chemical_list: D004791:Enzyme Inhibitors; D044950:Flavanones; D008543:Melanins; D014442:Monophenol Monooxygenase
keywords: Anti-tyrosinase activity; B16 murine melanoma cells; Dalea pazensis Rusby; Prenylated flavanones