title: Association of G308A and G238A Polymorphisms of the TNF-α Gene with Risk of Coronary Heart Disease: Systematic Review and Meta-analysis.
abstract: It is widely acknowledged that coronary heart disease (CHD) has a genetic influence. One of the most promising candidate genes is tumor necrosis factor-alpha (TNF-α). Although there have been several positive studies associating the TNF-α gene and CHD, the evidence is not entirely consistent. The aim of the study was to evaluate the role of the TNF-α gene in CHD using combined evidence by generating a meta-analysis and a systematic review of all published data.
  
  
  
  Meta-analysis and systematic review were conducted using 27 articles of genetic association studies of the TNF-α gene variants (G308A and G238A) and CHD. To analyze the association we used allelic, additive, dominant and recessive models. Moreover, we conducted a subanalysis by populations using the same four models.
  
  
  
  TNF-α variant G308A showed a significant association with CHD but only when the analysis comprised the whole population. In addition, the variant G238A yielded the same outcome in the Asian population.
  
  
  
  Genetic polymorphisms at positions -308 and -238 in the promoter region of the TNF-α gene may be useful as predictive factors for CHD.
authors.affiliation: División Académica de Ciencias de la Salud, Jalpa de Méndez, Tabasco, Mexico.
authors.forename: Karely
authors.initials: K
authors.lastname: Pulido-Gómez
authors.affiliation: División Académica Multidisciplinaria de Jalpa de Méndez, Jalpa de Méndez, Tabasco, Mexico.
authors.forename: Yazmín
authors.initials: Y
authors.lastname: Hernández-Díaz
authors.affiliation: División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, México.
authors.forename: Carlos Alfonso
authors.initials: CA
authors.lastname: Tovilla-Zárate
authors.affiliation: División Académica de Ciencias de la Salud, Jalpa de Méndez, Tabasco, Mexico.
authors.forename: Isela Esther
authors.initials: IE
authors.lastname: Juárez-Rojop
authors.affiliation: División Académica Multidisciplinaria de Jalpa de Méndez, Jalpa de Méndez, Tabasco, Mexico. Electronic address: thelma.glez.castro@gmail.com.
authors.forename: Thelma Beatriz
authors.initials: TB
authors.lastname: González-Castro
authors.affiliation: Hospital General de Yajalón, Secretaría de Salud, Yajalón, Chiapas, México.
authors.forename: María Lilia
authors.initials: ML
authors.lastname: López-Narváez
authors.affiliation: División Académica de Ciencias de la Salud, Jalpa de Méndez, Tabasco, Mexico.
authors.forename: Mariela
authors.initials: M
authors.lastname: Alpuin-Reyes
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Cardiovascular disease; Meta-analysis; Systematic review; TNF-α