title: Synthesis and cytotoxic activity of two steroids: icogenin aglycone analogs.
abstract: During the process of icogenin analog research, we obtained two cytotoxic steroids: compound 4 and compound 6 casually. Their in vitro antitumor activities were tested by the standard MTT assay. The results disclosed that compound 4 (IC50= 3.65-6.90 μM) showed potential antitumor activities against HELA, KB cell lines and compound 6 (IC50= 2.40-9.05 μM) showed potential antitumor activities against HELA, BGC-823, KB, A549, HCT-8 cell lines.
authors.affiliation: a Pharmacy Department , Traffic Hospital of Shandong Province , Jinan 250031 , China.
authors.forename: Yu-Yao
authors.initials: YY
authors.lastname: Guan
authors.affiliation: a Pharmacy Department , Traffic Hospital of Shandong Province , Jinan 250031 , China.
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Li
authors.affiliation: b State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing 100050 , China.
authors.forename: Ping-Sheng
authors.initials: PS
authors.lastname: Lei
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002777:Cholestanols / Q000737:chemistry; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D012503:Saponins / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002777:Cholestanols; C496798:Icogenin; D012503:Saponins; D013256:Steroids; C079655:squalamine
keywords: Steroid; antitumor; icogenin aglycone; synthesis