title: Diversity-oriented synthesis and cytotoxic activity evaluation of biaryl-containing macrocycles.
abstract: Synthesis of biaryl-containing macrocycles has been carried out through a four-step approach comprising two Ugi four component reactions and a Suzuki-Miyaura macrocyclization. This protocol allowed the synthesis of 12- and 14-membered macrocycles. Cytotoxic activity evaluation showed that some of the molecules were effective against leukemia, glioblastoma and lung cancer cell lines (IC50= 4.0, 5.9 and 7.6, respectively).
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior S.N., Ciudad Universitaria, Coyoacán, Ciudad de México, 04510, Mexico. lmiranda@unam.mx.
authors.forename: Karell
authors.initials: K
authors.lastname: Pérez-Labrada
authors.forename: Marco A
authors.initials: MA
authors.lastname: Cruz-Mendoza
authors.forename: Alejandra
authors.initials: A
authors.lastname: Chávez-Riveros
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hernández-Vázquez
authors.forename: Tomás
authors.initials: T
authors.lastname: Torroba
authors.forename: Luis D
authors.initials: LD
authors.lastname: Miranda
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D047028:Macrocyclic Compounds