title: From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal.
abstract: The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on the detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and which recognizes the highly variable impact of these tumors on patients.
authors.affiliation: Department of Pathology and Endocrine Oncology Site GroupPrincess Margaret Cancer Centre, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada sylvia.asa@uhn.ca Jacqueline.trouillas@univ-lyon1.fr.
authors.forename: S L
authors.initials: SL
authors.lastname: Asa
authors.affiliation: Department of PathologyUppsala University Hospital, Uppsala, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Casar-Borota
authors.affiliation: Service of Endocrinology and Reproductive DiseasesBicêtre Hospital, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Chanson
authors.affiliation: Department of MedicineUniversity of Louvain, Mont-sur-Meuse, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Delgrange
authors.affiliation: Department of Anatomical PathologySt Vincent's Hospital, Sydney, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Earls
authors.affiliation: Department of Medicine and Endocrine Oncology Site GroupPrincess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Ezzat
authors.affiliation: Department of EndocrinologyUniversity of Oxford, Oxford, UK.
authors.forename: A
authors.initials: A
authors.lastname: Grossman
authors.affiliation: Research Institute for Pituitary DiseaseSouthern Tohoku General Hospital, Fukushima, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
authors.affiliation: Department of PathologyToranomon Hospital, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Inoshita
authors.affiliation: Department of EndocrinologyQueen Elizabeth Hospital, University of Birmingham, Birmingham, UK.
authors.forename: N
authors.initials: N
authors.lastname: Karavitaki
authors.affiliation: Division of EndocrinologyQueen Mary Hospital, Barts and the London School of Medicine, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Korbonits
authors.affiliation: Department of NeurosurgeryHarvard Medical School, Brigham & Women's Hospital, Boston, Massachusetts, USA.
authors.forename: E R
authors.initials: ER
authors.lastname: Laws
authors.affiliation: Departments of Pathology and Neurological SurgeryUniversity of Virginia, Charlottesville, Virginia, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Lopes
authors.affiliation: Department of NeurosurgeryRoyal Melbourne Hospital, The University of Melbourne, Melbourne, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Maartens
authors.affiliation: Department of NeurosurgeryUT MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: I E
authors.initials: IE
authors.lastname: McCutcheon
authors.affiliation: Department of Pathology and Endocrine Oncology Site GroupPrincess Margaret Cancer Centre, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: O
authors.initials: O
authors.lastname: Mete
authors.affiliation: Department of NeurosurgeryToranomon Hospital, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nishioka
authors.affiliation: Department of EndocrinologyGroupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, France.
authors.forename: G
authors.initials: G
authors.lastname: Raverot
authors.affiliation: Department of NeuropathologyImperial College, London, UK.
authors.forename: F
authors.initials: F
authors.lastname: Roncaroli
authors.affiliation: Institute of Neuropathology of the University of HamburgHamburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Saeger
authors.affiliation: Department of NeurosurgeryHospital Pablo Tobon Uribe, Medellin, Colombia.
authors.forename: L V
authors.initials: LV
authors.lastname: Syro
authors.affiliation: Department of PathologyGroupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Vasiljevic
authors.affiliation: Department of PathologyHôpital Foch, Suresnes, France.
authors.forename: C
authors.initials: C
authors.lastname: Villa
authors.affiliation: INSERM U1052Cancer Research Center of Lyon, University of Lyon, Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Wierinckx
authors.affiliation: Faculty of Medicine Lyon-EstUniversity of Lyon, Lyon, France sylvia.asa@uhn.ca Jacqueline.trouillas@univ-lyon1.fr.
authors.forename: J
authors.initials: J
authors.lastname: Trouillas
mesh_terms: D000236:Adenoma / Q000145:classification*; D006801:Humans; D018358:Neuroendocrine Tumors / Q000145:classification*; D010911:Pituitary Neoplasms / Q000145:classification*
keywords: nomenclature; pituitary tumors