title: dMyc is required in retinal progenitors to prevent JNK-mediated retinal glial activation.
abstract: In the nervous system, glial cells provide crucial insulation and trophic support to neurons and are important for neuronal survival. In reaction to a wide variety of insults, glial cells respond with changes in cell morphology and metabolism to allow repair. Additionally, these cells can acquire migratory and proliferative potential. In particular, after axonal damage or pruning the clearance of axonal debris by glial cells is key for a healthy nervous system. Thus, bidirectional neuron-glial interactions are crucial in development, but little is known about the cellular sensors and signalling pathways involved. In here, we show that decreased cellular fitness in retinal progenitors caused by reduced Drosophila Myc expression triggers non cell-autonomous activation of retinal glia proliferation and overmigration. Glia migration occurs beyond its normal limit near the boundary between differentiated photoreceptors and precursor cells, extending into the progenitor domain. This overmigration is stimulated by JNK activation (and the function of its target Mmp1), while proliferative responses are mediated by Dpp/TGF-β signalling activation.
authors.affiliation: i3S -Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.|IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
authors.forename: Lígia
authors.identifier: 0000-0001-9487-7978
authors.initials: L
authors.lastname: Tavares
authors.affiliation: i3S -Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.|IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
authors.forename: Andreia
authors.initials: A
authors.lastname: Correia
authors.affiliation: i3S -Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.|IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
authors.forename: Marília A
authors.initials: MA
authors.lastname: Santos
authors.affiliation: i3S -Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.|IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
authors.forename: João B
authors.initials: JB
authors.lastname: Relvas
authors.affiliation: i3S -Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.|IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
authors.forename: Paulo S
authors.initials: PS
authors.lastname: Pereira
mesh_terms: D000818:Animals; D017209:Apoptosis; D001369:Axons / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement; D049109:Cell Proliferation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D004331:Drosophila melanogaster; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D048670:MAP Kinase Kinase 4 / Q000378:metabolism; D008297:Male; D055495:Neurogenesis; D009457:Neuroglia / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D017956:Photoreceptor Cells, Invertebrate / Q000378:metabolism*; D012160:Retina / Q000166:cytology; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C102284:Myc protein, Drosophila; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D048670:MAP Kinase Kinase 4