title: Trimetazidine in conditions other than coronary disease, old drug, new tricks?
abstract: Trimetazidine (TMZ) has traditionally been used as an anti-ischemic drug for coronary artery disease by selectively inhibiting the mitochondrial long-chain 3-ketoacyl-CoA thiolase. Recently, new applications for this therapy have been investigated. This article reviews alternative uses for TMZ in non-coronary artery diseases, such as non-ischemic cardiomyopathy, sepsis, myocardial dysfunction induced by anti-cancer drugs, diabetic cardiomyopathy and contrast-induced nephropathy.
authors.affiliation: Department of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou 310000, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Zou
authors.affiliation: Department of Nephrology, Zhejiang Provincial People's Hospital, Hangzhou 310000, China.
authors.forename: Xing-Xing
authors.initials: XX
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou 310000, China.
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Ding
authors.affiliation: Department of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou 310000, China.
authors.forename: Qin-Yang
authors.initials: QY
authors.lastname: Jin
authors.affiliation: Department of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou 310000, China. Electronic address: qly@zjheart.com.
authors.forename: Lin-Yan
authors.initials: LY
authors.lastname: Qian
authors.affiliation: Department of Hepatobiliary Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310000, China. Electronic address: dshuang@zjheart.com.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Huang
authors.affiliation: Department of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou 310000, China. Electronic address: cxj@zjheart.com.
authors.forename: Xue-Jiang
authors.initials: XJ
authors.lastname: Cen
mesh_terms: D000102:Acetyl-CoA C-Acyltransferase / Q000378:metabolism; D000970:Antineoplastic Agents / Q000009:adverse effects*; D064419:Chemically-Induced Disorders / Q000188:drug therapy* / Q000209:etiology; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000378:metabolism; D058065:Diabetic Cardiomyopathies / Q000188:drug therapy*; D058492:Drug Repositioning; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy; D008929:Mitochondria, Heart / Q000378:metabolism; D014292:Trimetazidine / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D014665:Vasodilator Agents; D000102:Acetyl-CoA C-Acyltransferase; D014292:Trimetazidine
keywords: Contrast-induced nephropathy; Diabetic cardiomyopathy; Myocardial dysfunction induced by anti-cancer drugs; Non-ischemic cardiomyopathy; Sepsis; Trimetazidine