title: Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways.
abstract: Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis (Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anti-cancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt (also known as protein kinase B) and AMP-activated protein kinase (AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. Furthermore, wogonin also decreases DNA adduct formation with a carcinogenic compound 2-Aminofluorene and inhibits growth of drug resistant malignant cells and their migration and metastasis, without any side effects. Recently, newly synthesized wogonin derivatives have been developed with impressive anti-tumor activity. This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin. We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment. Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed.
authors.affiliation: Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Do Luong
authors.initials: DL
authors.lastname: Huynh
authors.affiliation: Division of Veterinary Medicine, Faculty of Veterinary Science & Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences & Technology, R.S. Pura, Jammu 181102, India.
authors.forename: Neelesh
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar Singh
authors.affiliation: Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Simrinder
authors.initials: S
authors.lastname: Singh Sodhi
authors.affiliation: Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Jiao-Jiao
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Mongre
authors.affiliation: Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Mrinmoy
authors.initials: M
authors.lastname: Ghosh
authors.affiliation: Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Nameun
authors.initials: N
authors.lastname: Kim
authors.affiliation: BRM Institute, Seoul 06111, Republic of Korea.
authors.forename: Yang
authors.initials: Y
authors.lastname: Ho Park
authors.affiliation: Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea. Electronic address: dkjeong@jejunu.ac.kr.
authors.forename: Dong
authors.initials: D
authors.lastname: Kee Jeong
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D018736:DNA Adducts / Q000378:metabolism; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D044950:Flavanones / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D008517:Phytotherapy; D031364:Scutellaria baicalensis / Q000737:chemistry*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D018736:DNA Adducts; D004365:Drugs, Chinese Herbal; D044950:Flavanones; C085514:wogonin
keywords: Anti-cancer; Apoptosis; Pharmacokinetics; Signaling pathways; Wogonin