title: A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction.
abstract: A peptide vaccine targeting angiotensin II (Ang II) was recently developed as a novel treatment for hypertension to resolve the problem of noncompliance with pharmacotherapy. Ang II plays a crucial role in the pathogenesis of cardiac remodeling after myocardial infarction (MI), which causes heart failure. In the present study, we examined whether the Ang II vaccine is effective in preventing heart failure. The injection of the Ang II vaccine in a rat model of MI attenuated cardiac dysfunction in association with an elevation in the serum anti-Ang II antibody titer. Furthermore, any detrimental effects of the Ang II vaccine were not observed in the rats that underwent sham operations. Treatment with immunized serum from Ang II vaccine-injected rats significantly suppressed post-MI cardiac dysfunction in MI rats and Ang II-induced remodeling-associated signaling in cardiac fibroblasts. Thus, our present study demonstrates that the Ang II vaccine may provide a promising novel therapeutic strategy for preventing heart failure.
authors.affiliation: Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan.|Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Watanabe
authors.affiliation: Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Suzuki
authors.affiliation: Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Wakayama
authors.affiliation: Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Maejima
authors.affiliation: Department of Neurology, Osaka University, Graduate School of Medicine, Osaka, Japan.|Department of Health Development and Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: Munehisa
authors.initials: M
authors.lastname: Shimamura
authors.affiliation: Department of Health Development and Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koriyama
authors.affiliation: Department of Health Development and Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Nakagami
authors.affiliation: Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kumagai
authors.affiliation: Department of Cardiovascular Medicine, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ikeda
authors.affiliation: Department of Cardiovascular Medicine, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akazawa
authors.affiliation: Department of Clinical Gene Therapy, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Morishita
authors.affiliation: Department of Cardiovascular Medicine, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
authors.affiliation: Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan.
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Isobe
mesh_terms: D000804:Angiotensin II / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D006333:Heart Failure / Q000517:prevention & control*; D009203:Myocardial Infarction / Q000150:complications*; D051381:Rats; D016896:Treatment Outcome; D022223:Vaccines, Subunit / Q000008:administration & dosage* / Q000276:immunology*; D014662:Vasoconstrictor Agents / Q000037:antagonists & inhibitors* / Q000276:immunology
chemical_list: D022223:Vaccines, Subunit; D014662:Vasoconstrictor Agents; D000804:Angiotensin II