title: Isocyanide-Induced Activation of Copper Sulfate: Direct Access to Functionalized Heteroarene Sulfonic Esters.
abstract: A novel and direct approach to alkyl/aryl heteroarene sulfonic esters using copper sulfate as the environmentally benign inorganic sulfonation reagent was first realized with the aid of isocyanide. A variety of heterocycles reacted to afford the corresponding sulfonic esters through C-H functionalization. In this transformation, the otherwise inert copper sulfate was unusually activated by an isocyanide and employed as the source of the sulfonic substituents in an unprecedented fashion. The findings suggest that an appropriate activator may liberate the chemical activities of some relatively inert inorganic salts for organic synthesis.
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, School of Materials Science and Engineering, Shanghai University, Shanghai, 200444, China.
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Hong
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, School of Materials Science and Engineering, Shanghai University, Shanghai, 200444, China.
authors.forename: Qitao
authors.initials: Q
authors.lastname: Tan
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, School of Materials Science and Engineering, Shanghai University, Shanghai, 200444, China.
authors.forename: Bingxin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, School of Materials Science and Engineering, Shanghai University, Shanghai, 200444, China.|State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.|Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai, 200062, China.
authors.forename: Bin
authors.identifier: 0000-0002-9251-6930
authors.initials: B
authors.lastname: Xu
keywords: C−H activation; copper sulfate; heterocycles; isocyanide; sulfonation