title: Properties of skin stem cells and their potential clinical applications in modern dermatology.
abstract: Stem cells play an important role in medical science, and scientists are investing large sums in order to perform sophisticated studies designed to establish potential clinical applications of stem cells. Growing experience has enabled researchers to determine the precise nature of stem cell division. Although the properties of this particular population of cells have been known and used for some time, mainly with regards to bone marrow-derived mesenchymal stem cell transplantation, we now face a significant challenge in implementing the practical use of skin-derived precursors, making it possible to avoid the necessity for patients to undergo invasive procedures in order to obtain stem cells from bone marrow. Multiple trials have so far been performed, bringing hope for the treatment of disorders previously considered untreatable. Patients suffering from a number of dermatological diseases, including malignant melanoma, systemic lupus erythematosus, vitiligo, alopecia or junctional epidermolysis bullosa, may benefit from treatment based on stem cells. The aim of this review is to summarize available data on stem cells and their potential applications in the treatment of dermatological disorders. The work described is based on data published up to the end of September 2016.
authors.affiliation: Nicolaus Copernicus University in Toruń, Faculty of Medicine, Chair of Dermatology, Sexually Transmitted Diseases, Immunodermatology, Toruń, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Niezgoda
authors.affiliation: Department of Principles of Clinical Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Niezgoda
authors.affiliation: Nicolaus Copernicus University in Toruń, Faculty of Medicine, Chair of Dermatology, Sexually Transmitted Diseases, Immunodermatology, Toruń, Poland.
authors.forename: Laura
authors.initials: L
authors.lastname: Nowowiejska
authors.affiliation: Nicolaus Copernicus University in Toruń, Faculty of Medicine, Chair of Dermatology, Sexually Transmitted Diseases, Immunodermatology, Toruń, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Białecka
authors.affiliation: Nicolaus Copernicus University in Toruń, Faculty of Medicine, Chair of Dermatology, Sexually Transmitted Diseases, Immunodermatology, Toruń, Poland.
authors.forename: Kaja
authors.initials: K
authors.lastname: Męcińska-Jundziłł
authors.affiliation: Nicolaus Copernicus University in Toruń, Faculty of Medicine, Chair of Dermatology, Sexually Transmitted Diseases, Immunodermatology, Toruń, Poland.
authors.forename: Urszula
authors.initials: U
authors.lastname: Adamska
authors.affiliation: Nicolaus Copernicus University in Toruń, Faculty of Medicine, Chair of Dermatology, Sexually Transmitted Diseases, Immunodermatology, Toruń, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Czajkowski
mesh_terms: D000273:Adipose Tissue / Q000166:cytology; D002454:Cell Differentiation; D000067470:Cellular Reprogramming Techniques; D000078404:Epidermal Cells; D048091:Guided Tissue Regeneration; D018859:Hair Follicle / Q000166:cytology; D006801:Humans; D020286:Pericytes / Q000502:physiology; D012627:Sebaceous Glands / Q000166:cytology; D012867:Skin / Q000166:cytology*; D012871:Skin Diseases / Q000628:therapy*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*
keywords: dermatology; skin; stem cell; therapy; treatment