title: A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection.
abstract: One of the largest single sources of epilepsy in the world is produced as a neurological sequela in survivors of cerebral malaria. Nevertheless, the pathophysiological mechanisms of such epileptogenesis remain unknown and no adjunctive therapy during cerebral malaria has been shown to reduce the rate of subsequent epilepsy. There is no existing animal model of postmalarial epilepsy. In this technical report we demonstrate the first such animal models. These models were created from multiple mouse and parasite strain combinations, so that the epilepsy observed retained universality with respect to genetic background. We also discovered spontaneous sudden unexpected death in epilepsy (SUDEP) in two of our strain combinations. These models offer a platform to enable new preclinical research into mechanisms and prevention of epilepsy and SUDEP.
authors.affiliation: Center for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Engineering Science and Mechanics, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.
authors.forename: Paddy
authors.initials: P
authors.lastname: Ssentongo
authors.affiliation: Center for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Engineering Science and Mechanics, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.
authors.forename: Anna E
authors.initials: AE
authors.lastname: Robuccio
authors.affiliation: Center for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Engineering Science and Mechanics, Penn State University, University Park, Pennsylvania 16802, USA.
authors.forename: Godfrey
authors.initials: G
authors.lastname: Thuku
authors.affiliation: Center for Infectious Disease Dynamics, Penn State University, University Park, Pennsylvania 16802, USA.|Departments of Biology and Entomology, Penn State University, University Park, Pennsylvania 16802, USA.
authors.forename: Derek G
authors.initials: DG
authors.lastname: Sim
authors.affiliation: Center for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Engineering Science and Mechanics, Penn State University, University Park, Pennsylvania 16802, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Nabi
authors.affiliation: Center for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Engineering Science and Mechanics, Penn State University, University Park, Pennsylvania 16802, USA.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Bahari
authors.affiliation: Center for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Engineering Science and Mechanics, Penn State University, University Park, Pennsylvania 16802, USA.
authors.forename: Balaji
authors.initials: B
authors.lastname: Shanmugasundaram
authors.affiliation: Center for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Engineering Science and Mechanics, Penn State University, University Park, Pennsylvania 16802, USA.
authors.forename: Myles W
authors.initials: MW
authors.lastname: Billard
authors.affiliation: Center for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Engineering Science and Mechanics, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Geronimo
authors.affiliation: Center for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Engineering Science and Mechanics, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.
authors.forename: Kurt W
authors.initials: KW
authors.lastname: Short
authors.affiliation: Center for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Engineering Science and Mechanics, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.|Department of Bioengineering, Penn State University, University Park, Hershey, Pennsylvania, 16803, USA.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Drew
authors.affiliation: Department of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.|Department of Pathology, Penn State College of Medicine, Hershey, Hershey, Pennsylvania 17033, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Baccon
authors.affiliation: Department of Neurology, Children's National Medical Center, George Washington University, Washington, DC 20010, USA.
authors.forename: Steven L
authors.initials: SL
authors.lastname: Weinstein
authors.affiliation: Department of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.|Department of Neurology, Penn State College of Medicine, Hershey, Hershey, Pennsylvania 17033, USA.
authors.forename: Frank G
authors.initials: FG
authors.lastname: Gilliam
authors.affiliation: Department of Medicine, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA.
authors.forename: José A
authors.initials: JA
authors.lastname: Stoute
authors.affiliation: Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.
authors.forename: Vernon M
authors.initials: VM
authors.lastname: Chinchilli
authors.affiliation: Center for Infectious Disease Dynamics, Penn State University, University Park, Pennsylvania 16802, USA.|Departments of Biology and Entomology, Penn State University, University Park, Pennsylvania 16802, USA.
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Read
authors.affiliation: Center for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Engineering Science and Mechanics, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.|Department of Bioengineering, Penn State University, University Park, Hershey, Pennsylvania, 16803, USA.
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Gluckman
authors.affiliation: Center for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Engineering Science and Mechanics, Penn State University, University Park, Pennsylvania 16802, USA.|Center for Infectious Disease Dynamics, Penn State University, University Park, Pennsylvania 16802, USA.|Department of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.|Department of Physics, Penn State University, University Park, Pennsylvania, 16803, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Schiff
mesh_terms: D000818:Animals; D003645:Death, Sudden / Q000209:etiology*; D004195:Disease Models, Animal; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications* / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D016779:Malaria, Cerebral / Q000150:complications* / Q000469:parasitology / Q000473:pathology; D008297:Male; D051379:Mice; D010962:Plasmodium berghei; D016019:Survival Analysis