title: Correlation of Chitinase 3-Like 1 Single Nucleotide Polymorphisms with Hepatocellular Carcinoma in Taiwan.
abstract: Hepatocellular carcinoma (HCC) is the second leading cause of cancer death in Taiwan. Multiple risk factors, such as chronic hepatitis B or C virus infection, carcinogen exposure, cirrhosis, and various single-nucleotide polymorphisms (SNPs), are considered to contribute to hepatocarcinogenesis. Chitinase-3-like protein 1 (CHI3L1), a biomarker implicated in inflammation and tissue remodeling, plays a promoting role in angiogenesis, antiapoptosis, and cell proliferation. This study investigated the role ofCHI3L1SNPs in HCC susceptibility and clinicopathology. Real-time polymerase chain reaction was used to analyze four SNPs ofCHI3L1in 343 patients with HCC and 686 cancer-free controls. We found associations with HCC susceptibility inCHI3L1rs880633 polymorphism carriers with genotypes (TC+CC). We observed that HCC patients had lower frequencies ofCHI3L1rs6691378 polymorphisms with the variant genotype GA+AA than the wild-type carriers with distant metastasis and positive HBsAg did. In 200 HBsAg negative HCC patients, we observed that theCHI3L1rs4950928 polymorphisms carriers with the variant genotype CG+GG had higher frequencies of vascular invasion. Finally, carriers ofCHI3L1rs6691378 and 10399805 polymorphisms with the variant genotypes GA+AA showed lower levels of alpha-fetoprotein in HCC laboratory status. In conclusion, our results indicate that patients withCHI3L1rs880633 variant genotypes TC+CC are at a higher risk of HCC.CHI3L1polymorphisms rs880633 or rs4950928 may be potential candidates for predicting poor HCC prognosis and clinical status.
authors.affiliation: Department of Surgery, Show Chwan Memorial Hospital, Changhua, Taiwan.
authors.forename: Wayne Shih-Wei
authors.initials: WS
authors.lastname: Huang
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan; Department of Optometry, Yuan Pei University, Hsinchu, Taiwan.
authors.forename: Hung-Yu
authors.initials: HY
authors.lastname: Lin
authors.affiliation: School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Chao-Bin
authors.initials: CB
authors.lastname: Yeh
authors.affiliation: Department of Anatomy, Faculty of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Li-You
authors.initials: LY
authors.lastname: Chen
authors.affiliation: School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Ying-Erh
authors.initials: YE
authors.lastname: Chou
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Shun-Fa
authors.initials: SF
authors.lastname: Yang
authors.affiliation: Department of Biomedical Sciences, College of Medicine Sciences and Technology, Chung Shan Medical University, Taichung, Taiwan; Division of Allergy, Department of Pediatrics, Chung-Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Yu-Fan
authors.initials: YF
authors.lastname: Liu
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology* / Q000235:genetics*; D000071451:Chitinase-3-Like Protein 1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D013624:Taiwan / Q000453:epidemiology
chemical_list: C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1
keywords: CHI3L1; Hepatocellular carcinoma; Single nucleotide polymorphism