title: High blood pressure variability predicts 30-day mortality but not 1-year mortality in hospitalized elderly patients.
abstract: BACKGROUND
  The association of blood pressure (BP) variability (BPV) in hospitalized patients, which represents day-to-day variability, with mortality has been extensively reported in patients with stroke, but poorly defined for other medical conditions.
  
  
  OBJECTIVE
  To assess the association of day-to-day blood pressure variability in hospitalized patients, 10 BP measurements were obtained in individuals ≥75 years old hospitalized in a geriatric ward. Day-to-day BPV, measured 3 times a day, was calculated in each patient as the coefficient of variation of systolic BP. Patients were stratified by quartiles of coefficient of variation of systolic BP, and 30-day and 1-year mortality data were compared between those in the highest versus the lowest (reference) group.
  
  
  RESULTS
  Overall, 469 patients were included in the final analysis. Mean coefficient of variation of systolic BP was 12.1%. 30-day mortality and 1-year mortality occurred in 29/469 (6.2%) and 95/469 (20.2%) individuals respectively. Patients in the highest quartile of BPV were at a significantly higher risk for 30-day mortality (HR =4.12, CI 1.12-15.10) but not for 1-year mortality compared with the lowest BPV quartile (HR =1.61, CI 0.81-3.23).
  
  
  CONCLUSIONS
  Day-to-day BPV is associated with 30-day, but not with 1-year mortality in hospitalized elderly patients.
authors.affiliation: a Department of Geriatrics , Rabin Medical Center, Beilinson campus , Petah Tikva , Israel.|b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
authors.forename: Avraham
authors.initials: A
authors.lastname: Weiss
authors.affiliation: b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.|c Internal Medicine E , Rabin Medical Center, Beilinson campus , Petah Tikva , Israel.
authors.forename: Yaron
authors.initials: Y
authors.lastname: Rudman
authors.affiliation: a Department of Geriatrics , Rabin Medical Center, Beilinson campus , Petah Tikva , Israel.|b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
authors.forename: Yichayaou
authors.initials: Y
authors.lastname: Beloosesky
authors.affiliation: b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.|d Unit of Endocrinology and Metabolism , Rabin Medical Center, Beilinson campus , Petah Tikva , Israel.
authors.forename: Amit
authors.initials: A
authors.lastname: Akirov
authors.affiliation: b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.|e Bio-statistical Unit , Rabin Medical Center, Beilinson Campus , Petah Tikva , Israel.
authors.forename: Tzippy
authors.initials: T
authors.lastname: Shochat
authors.affiliation: b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.|c Internal Medicine E , Rabin Medical Center, Beilinson campus , Petah Tikva , Israel.
authors.forename: Alon
authors.initials: A
authors.lastname: Grossman
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D005260:Female; D006801:Humans; D006973:Hypertension / Q000401:mortality* / Q000503:physiopathology; D008297:Male; D009026:Mortality
keywords: Blood pressure; elderly; mortality; variability