title: Association between numbers of decayed teeth and HbA1c in Japanese patients with type 2 diabetes mellitus.
abstract: BACKGROUND
  Dental caries (DC) are more prevalent in individuals with diabetes than in healthy individuals. However, the association between glycaemic control and DC has not been well characterized in patients with type 2 diabetes mellitus (T2DM). We therefore assessed the association between glycated haemoglobin (HbA1c) serum concentrations and the prevalence of DC in patients with T2DM.
  
  
  METHODS
  Retrospective analyses of data pertaining to 108 Japanese patients with T2DM hospitalized because of poor or worsened glycaemic control were included. We divided the patients based on HbA1c into two groups: HbA1c level ≥75 mmol/mol (9.0%) as poorly controlled T2DM, and HbA1c level <75 mmol/mol (9.0%) as a control group. We compared the association of lifestyle factors, dental caries, and periodontal health between patients with poorly controlled T2DM and controls. Stepwise multiple regression analyses were performed to evaluate the association between HbA1c, the absolute number of decayed teeth (DT), the sum of decayed, missing, and filled teeth, and the Met Need Index (MNI).
  
  
  RESULTS
  DT was higher and MNI was lower in patients with poorly controlled T2DM as compared to that in controls (P = 0.006 and P = 0.004, respectively). Multiple regression analyses revealed a significant association between HbA1c levels and DT (adjusted β = 0.039, 95% confidence interval [CI], 0.005 to 0.072, P = 0.025) and the MNI (adjusted β = -0.216, 95% CI -0.374 to -0.058, P = 0.008).
  
  
  CONCLUSIONS
  DT and MNI were associated with HbA1c in T2DM patients.
authors.affiliation: a Department of Endocrinology , Tochigi Medical Center Shimotsuga, Ohira-machi Kawatsure 420-1 , Tochigi City , Tochigi , Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Yonekura
authors.affiliation: b Usui Dental Office , 12-14 Numawada-machi , Tochigi City , Tochigi , Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Usui
authors.affiliation: a Department of Endocrinology , Tochigi Medical Center Shimotsuga, Ohira-machi Kawatsure 420-1 , Tochigi City , Tochigi , Japan.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Murano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003731:Dental Caries / Q000097:blood* / Q000150:complications; D048909:Diabetes Complications / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006760:Hospitalization; D006801:Humans; D007564:Japan; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin
keywords: Dental caries; diabetes; haemoglobin A1c; systemic disease