title: Retrospective Analysis of Emerging Drugs Use in a Quebec Women's and Children's University Hospital and Perspectives for Safe and Optimal Drug Use.
abstract: Only few medicines are licensed for children. The use of emerging drugs (unmarketed drug, off-label drug with poorly documented use, and/or costly drugs) might represent an essential alternative for pediatric patients.
  
  
  
  The objective of the study was to assess emerging drug uses rate and profile in our women's and children's centre to support the implementation of an appropriate policy.
  
  
  
  We identified retrospectively emerging drugs used between 2013-01-01 and 2014-02-28, using computerized pharmacist software extraction of drugs used. Conventional oncologic drugs were excluded. Retrospective analysis of medical charts for patients who received an emerging drug and literature review for each drug were performed to determine efficacy and safety endpoints. Median delays between first intention and final decision to use the drug and between final decision and first administration were calculated. Proportion of patients who experienced a positive evolution under treatment or a side effect possibly related to the drug was calculated.
  
  
  
  A total of 26 emerging drugs were identified (89 patients, 99 uses). Median treatment duration was 66 days [1-1435]. Median delay between first evocation and final decision to use the drug was 2 days [0-333] and 0 day [0-404] between final decision and first administration. 52/99 (53%) of patients experienced a positive evolution under treatment and 26/99 (26%) experienced a side effect possibly related to emerging drug use.
  
  
  
  This study allowed us to describe emerging drug uses in a women and children tertiary hospital. It led to the implementation of a local emerging drug use policy ensuring optimal and safe use of these drugs. There is a significant number of emerging drugs used in pediatric which shows positive improvement in 56% of patients.
authors.affiliation: Unité de recherche en Pratique Pharmaceutique, CHU Sainte-Justine, Montréal, QC, Canada.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Corny
authors.affiliation: Département de Pharmacie, CHU Sainte-Justine, Montréal, QC, Canada.
authors.forename: Elaine
authors.initials: E
authors.lastname: Pelletier
authors.affiliation: Unité de recherche en Pratique Pharmaceutique, CHU Sainte-Justine, Montréal, QC, Canada.|Département de Pharmacie, CHU Sainte-Justine, Montréal, QC, Canada.
authors.forename: Denis
authors.initials: D
authors.lastname: Lebel
authors.affiliation: Unité de recherche en Pratique Pharmaceutique, CHU Sainte-Justine, Montréal, QC, Canada.|Département de Pharmacie, CHU Sainte-Justine, Montréal, QC, Canada.|Pharmacoeconomic and Pharmacoepidemiology unit, Centre de recherche du Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Bussières
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017277:Drug Approval / Q000706:statistics & numerical data*; D006785:Hospitals, University / Q000458:organization & administration / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D056687:Off-Label Use / Q000706:statistics & numerical data*; D061214:Patient Safety; D010372:Pediatrics / Q000458:organization & administration / Q000706:statistics & numerical data*; D010818:Practice Patterns, Physicians'; D011792:Quebec; D012189:Retrospective Studies; D062606:Tertiary Care Centers / Q000458:organization & administration / Q000706:statistics & numerical data*; D013997:Time Factors
keywords: emerging drugs; off-label; pediatrics; unlicensed