title: Radiomics Features of Multiparametric MRI as Novel Prognostic Factors in Advanced Nasopharyngeal Carcinoma.
abstract: Purpose:To identify MRI-based radiomics as prognostic factors in patients with advanced nasopharyngeal carcinoma (NPC).Experimental Design:One-hundred and eighteen patients (training cohort:n= 88; validation cohort:n= 30) with advanced NPC were enrolled. A total of 970 radiomics features were extracted from T2-weighted (T2-w) and contrast-enhanced T1-weighted (CET1-w) MRI. Least absolute shrinkage and selection operator (LASSO) regression was applied to select features for progression-free survival (PFS) nomograms. Nomogram discrimination and calibration were evaluated. Associations between radiomics features and clinical data were investigated using heatmaps.Results:The radiomics signatures were significantly associated with PFS. A radiomics signature derived from joint CET1-w and T2-w images showed better prognostic performance than signatures derived from CET1-w or T2-w images alone. One radiomics nomogram combined a radiomics signature from joint CET1-w and T2-w images with the TNM staging system. This nomogram showed a significant improvement over the TNM staging system in terms of evaluating PFS in the training cohort (C-index, 0.761 vs. 0.514;P< 2.68 × 10-9). Another radiomics nomogram integrated the radiomics signature with all clinical data, and thereby outperformed a nomogram based on clinical data alone (C-index, 0.776 vs. 0.649;P< 1.60 × 10-7). Calibration curves showed good agreement. Findings were confirmed in the validation cohort. Heatmaps revealed associations between radiomics features and tumor stages.Conclusions:Multiparametric MRI-based radiomics nomograms provided improved prognostic ability in advanced NPC. These results provide an illustrative example of precision medicine and may affect treatment strategies.Clin Cancer Res; 23(15); 4259-69. ©2017 AACR.
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.|Graduate College, Southern Medical University, Guangzhou, Guangdong, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Molecular Imaging, Chinese Academy of Science, Beijing, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.affiliation: Key Laboratory of Molecular Imaging, Chinese Academy of Science, Beijing, P.R. China.
authors.forename: Di
authors.initials: D
authors.lastname: Dong
authors.affiliation: Key Laboratory of Molecular Imaging, Chinese Academy of Science, Beijing, P.R. China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Gu
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.|Shantou University Medical College, Guangdong, P.R. China.
authors.forename: Yuhao
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.|Graduate College, Southern Medical University, Guangzhou, Guangdong, P.R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.|Graduate College, Southern Medical University, Guangzhou, Guangdong, P.R. China.
authors.forename: Zhouyang
authors.initials: Z
authors.lastname: Lian
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.|Graduate College, Southern Medical University, Guangzhou, Guangdong, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.|Graduate College, Southern Medical University, Guangzhou, Guangdong, P.R. China.
authors.forename: Xiaoning
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.|Graduate College, Southern Medical University, Guangzhou, Guangdong, P.R. China.
authors.forename: Shufang
authors.initials: S
authors.lastname: Pei
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.|Shantou University Medical College, Guangdong, P.R. China.
authors.forename: Xiaokai
authors.initials: X
authors.lastname: Mo
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.|School of Medicine, South China University of Technology, Guangzhou, Guangdong, P.R. China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.|Graduate College, Southern Medical University, Guangzhou, Guangdong, P.R. China.
authors.forename: Fusheng
authors.initials: F
authors.lastname: Ouyang
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.|Graduate College, Southern Medical University, Guangzhou, Guangdong, P.R. China.
authors.forename: Baoliang
authors.initials: B
authors.lastname: Guo
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.|Graduate College, Southern Medical University, Guangzhou, Guangdong, P.R. China.
authors.forename: Long
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Radiology, Huizhou Municipal Central Hospital, Huizhou, Guangdong, P.R. China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China.
authors.forename: Changhong
authors.initials: C
authors.lastname: Liang
authors.affiliation: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China. shui7515@126.com.
authors.forename: Shuixing
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000473:pathology; D002681:China; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000473:pathology; D009367:Neoplasm Staging; D049451:Nomograms; D011379:Prognosis; D012307:Risk Factors