title: Synthesis of fullerene (C60-monoadduct)-based water-compatible imprinted micelles for electrochemical determination of chlorambucil.
abstract: A novel water-compatible C60-monoadduct based imprinted micelles was synthesized by the self-assembly of vinylic-C60-monoadduct with sodium dodecylsulfate micellar system, in the presence of chlorambucil as a model template (anticancer drug). After template retrieval with acetonitrile, these imprinted micelles were immobilized at the surface of ionic liquid decorated carbon ceramic electrode. Herein, C60-monoadduct (the head group of micelle) actually served as a nanomediator for electronic transmission across multiple interfaces. Such modification induced electrocatalytic characteristics by decreasing analyte oxidation overpotential and thereby augmented the electrode kinetics. Consequently, the differential pulse anodic stripping transduction was realized to be approximately four-fold as compared to the corresponding electrode modified without C60-monoadduct. This revealed the potential role of fullerene as nanomediator in the signal transduction. Herein, ionic liquids facilitated electron transport by two-fold without any interfacial barrier through carbon layers than that realized with modified ceramic electrodes made in the absence of ionic liquids. A perfect linearity in the current-concentration profile under optimal conditions was observed for the analyte concentration in the range 1.47-247.20ngmL-1, with the detection limits to the tune of 0.36ngmL-1(S/N=3) in aqueous and real samples.
authors.affiliation: Analytical Division, Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India. Electronic address: prof.bbpd@yahoo.com.
authors.forename: Bhim Bali
authors.initials: BB
authors.lastname: Prasad
authors.affiliation: Analytical Division, Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
authors.forename: Ragini
authors.initials: R
authors.lastname: Singh
authors.affiliation: Analytical Division, Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D002699:Chlorambucil / Q000737:chemistry / Q000302:isolation & purification*; D055664:Electrochemical Techniques / Q000379:methods*; D037741:Fullerenes / Q000737:chemistry*; D008823:Micelles; D054802:Molecular Imprinting; D014867:Water / Q000737:chemistry
chemical_list: D037741:Fullerenes; D008823:Micelles; D014867:Water; D002699:Chlorambucil; C069837:fullerene C60
keywords: C(60)-monoadduct; C(60)-monoadduct-micellar MIP; Chlorambucil; Electrochemical sensor; Molecularly imprinted polymer