title: Cytotoxic diterpenoids from Pteris ensiformis.
abstract: Phytochemistry investigation on Pteris ensiformis led to the isolation of a new ent-kaurane diterpenoid, ent-kaurane-6β,16α-diol-3-one (1), along with five known diterpenoids (2-6) and three known sesquiterpenes (7-9). Their structures were established by means of spectroscopic methods. The ethanol extract and the isolated compounds (1-9) were evaluated for their antitumor activity against three cancer cell lines.
authors.affiliation: a Key Laboratory of Biotechnology and Bioresources Utilization, The State Ethnic Affairs Commission-Ministry of Education , College of Life Science, Dalian Nationalities University , Dalian 116600 , China.
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Shi
authors.affiliation: b Jiamusi College , Heilongjiang University of Chinese Medicine , Jiamusi 154007 , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of Biotechnology and Bioresources Utilization, The State Ethnic Affairs Commission-Ministry of Education , College of Life Science, Dalian Nationalities University , Dalian 116600 , China.
authors.forename: Wen-Zhong
authors.initials: WZ
authors.lastname: Hu
authors.affiliation: b Jiamusi College , Heilongjiang University of Chinese Medicine , Jiamusi 154007 , China.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Zhang
authors.affiliation: c Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100193 , China.|d Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Branch , Jinghong 666100 , China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: b Jiamusi College , Heilongjiang University of Chinese Medicine , Jiamusi 154007 , China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: d Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Branch , Jinghong 666100 , China.
authors.forename: Guang
authors.initials: G
authors.lastname: Li
authors.affiliation: e Department of Endocrinology , The First Affiliated Hospital of Jiamusi University , Jiamusi 154003 , China.
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Tan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032495:Pteris / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045786:Diterpenes, Kaurane; C000616054:ent-kaurane-6beta,16alpha-diol-3-one
keywords: 16α-diol-3-one; Pteridaceae; Pteris ensiformi; cytotoxicity; ent-kaurane diterpenoid; ent-kaurane-6β