title: A measure of cortico-cortical potentials evoked by 10 Hz direct electrical stimulation of the brain and by means of a differential recording mode of electrocorticographic signals.
abstract: Direct electrical stimulation (DES) at 60 Hz is used to perform real-time functional mapping of the brain during wide-awake neurosurgery. The electrophysiological effects of DES are largely unknown, locally and at a more remote distance. Here, by lowering the DES frequency to 10 Hz and by using a differential recording mode of electro-corticographic (ECoG) signals to improve the focality, we were able to record cortico-cortical evoked potentials easily with standard current amplitude of stimulation (2 mA). DES applied at 10 Hz and differential recording of ECoG could be used to map on-line the connectivity between different sub-cortical and cortical areas with a higher spatial accuracy.
authors.forename: Marion
authors.initials: M
authors.lastname: Vincent
authors.forename: Olivier
authors.initials: O
authors.lastname: Rossel
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
authors.forename: Francois
authors.initials: F
authors.lastname: Bonnetblanc
authors.forename: David
authors.initials: D
authors.lastname: Guiraud
mesh_terms: D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D004558:Electric Stimulation / Q000379:methods*; D000069280:Electrocorticography / Q000379:methods*; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D019635:Neurosurgical Procedures; D014851:Wakefulness / Q000502:physiology