title: Cytotoxic Naphthoquinone and Azaanthraquinone Derivatives from an Endophytic Fusarium solani.
abstract: Bioactivity-guided fractionation of the ethyl acetate extract obtained from the culture of the endophytic fungus Fusarium solani resulted in the isolation of one new naphthoquinone, 9-desmethylherbarine (1), and two azaanthraquinone derivatives, 7-desmethylscorpinone (2) and 7-desmethyl-6-methylbostrycoidin (3), along with four known compounds. Their structures were elucidated by spectral analysis, as well as a direct comparison of spectral data with those of known compounds. Azaanthraquinones 2 and 3 showed cytotoxic activity against four human tumor cell lines, MDA MB 231, MIA PaCa2, HeLa, and NCI H1975. A molecular docking study suggested DNA interactions as the mode of action of these naphthoquinones and azaanthraquinones.
authors.affiliation: Pharmaceutical Sciences Research Division (PSRD), BCSIR Laboratories, Dhaka , Dr. Qudrat-I-Khuda Road, Dhanmondi, Dhaka, Bangladesh.|Department of Pharmacy, Manarat International University , Dhaka, Bangladesh.|Department of Pharmacy, Jahangirnagar University , Savar, Dhaka, Bangladesh.
authors.forename: Nargis Sultana
authors.initials: NS
authors.lastname: Chowdhury
authors.affiliation: Pharmaceutical Sciences Research Division (PSRD), BCSIR Laboratories, Dhaka , Dr. Qudrat-I-Khuda Road, Dhanmondi, Dhaka, Bangladesh.
authors.forename: Md Hossain
authors.initials: MH
authors.lastname: Sohrab
authors.affiliation: Department of Pharmacy, Jahangirnagar University , Savar, Dhaka, Bangladesh.
authors.forename: Md Sohel
authors.initials: MS
authors.lastname: Rana
authors.affiliation: Department of Pharmaceutical Chemistry, University of Dhaka , Dhaka, Bangladesh.
authors.forename: Choudhury Mahmood
authors.initials: CM
authors.lastname: Hasan
authors.affiliation: Institute of Pharmaceutical Sciences, King's College London , 7 Trinity Street, London SE1 1DB, U.K.
authors.forename: Shirin
authors.initials: S
authors.lastname: Jamshidi
authors.affiliation: Institute of Pharmaceutical Sciences, King's College London , 7 Trinity Street, London SE1 1DB, U.K.
authors.forename: Khondaker Miraz
authors.identifier: 0000-0001-8566-8648
authors.initials: KM
authors.lastname: Rahman
mesh_terms: D000085:Acetates; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001372:Aza Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005670:Fusarium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D062105:Molecular Docking Simulation; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000085:Acetates; D000880:Anthraquinones; D000970:Antineoplastic Agents; D001372:Aza Compounds; D009285:Naphthoquinones; C007650:ethyl acetate