title: Phage therapy is highly effective against chronic lung infections withPseudomonas aeruginosa.
abstract: With an increase in cases of multidrug-resistantPseudomonas aeruginosa, alternative and adjunct treatments are needed, leading to renewed interest in bacteriophage therapy. There have been few clinically relevant studies of phage therapy against chronic lung infections. Using a novel murine model that uses a natural respiratory inhalation route of infection, we show that phage therapy is an effective treatment against chronicP. aeruginosalung infections. We also show efficacy againstP. aeruginosain a biofilm-associated cystic fibrosis lung-like environment. These studies demonstrate the potential for phage therapy in the treatment of established and recalcitrant chronic respiratory tract infections.
authors.affiliation: Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
authors.forename: Elaine M
authors.identifier: 0000-0002-6573-3462
authors.initials: EM
authors.lastname: Waters
authors.affiliation: Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Neill
authors.affiliation: Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
authors.forename: Basak
authors.initials: B
authors.lastname: Kaman
authors.affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
authors.forename: Jaspreet S
authors.initials: JS
authors.lastname: Sahota
authors.affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
authors.forename: Martha R J
authors.initials: MRJ
authors.lastname: Clokie
authors.affiliation: Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
authors.forename: Craig
authors.initials: C
authors.lastname: Winstanley
authors.affiliation: Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
authors.forename: Aras
authors.initials: A
authors.lastname: Kadioglu
mesh_terms: D000818:Animals; D018441:Biofilms; D002908:Chronic Disease; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D051379:Mice; D008807:Mice, Inbred BALB C; D000071059:Phage Therapy; D011552:Pseudomonas Infections / Q000628:therapy*; D011550:Pseudomonas aeruginosa; D012141:Respiratory Tract Infections / Q000628:therapy*; D013997:Time Factors
keywords: Bacterial Infection; Cystic Fibrosis; Respiratory Infection