title: Applicability of the EORTC risk tables to predict outcomes in non-muscle-invasive bladder cancer in Turkish patients.
abstract: OBJECTIVE
  To evaluate the consistency of the results of patients who were treated for non-muscle-invasive bladder cancer (NMIBC) in our clinic with the European Organization for Research and Treatment of Cancer (EORTC) risk table.
  
  
  METHODS
  Data were retrospectively analyzed from 452 patients who had undergone transurethral resection of bladder tumor (TUR-BT) between the years 2002, and 2010 for primary or recurrent NMIBC. Our study had a retrospective design but based on prospective cohort study. Patients were staged according to the 2002 Tumor Node Metastasis (TNM) classification and the 1973 World Health Organization grading system. Recurrence was defined as non-muscle-invasive or muscle-invasive and progression as muscle-invasive tumor determined based on following cystoscopy and TUR-BT results, and confirmed by histopathologic analysis. Patients in the current study were classified into four groups according to the EORTC risk tables. Time to first recurrence and progression was determined for each risk group.
  
  
  RESULTS
  Of the 452 patients, 348 were enrolled in this study. The overall mean follow-up period was 55.25 months of all patients. Of 348 patients, 130 (37.4%) and 258 patients (74.1%) had recurrence after treatment at the 1 and 5 year follow-up period, respectively. While 35 (10.1%) and 99 patients (28.4%) progressed to muscle-invasive cancer at the 1 and 5 year follow-up period, respectively. In the multivariate analysis, grade, number, size of the tumor size, and concomitant carcinoma in situ were found to be statistically significant for disease progression and recurrence.
  
  
  CONCLUSIONS
  When EORTC risk tables were comparatively evaluated in our patient population, we can say that EORTC tables predict nearly accurately the clinical course of patients with NMIBC.
authors.affiliation: Clinic of Urology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Muhammet Fatih
authors.initials: MF
authors.lastname: Kılınç
authors.affiliation: Clinic of Urology, İdil State Hospital, Şırnak, Turkey.
authors.forename: Göksel
authors.initials: G
authors.lastname: Bayar
authors.affiliation: Clinic of Urology, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Dalkılıç
authors.affiliation: Clinic of Urology, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.
authors.forename: Nurettin Cem
authors.initials: NC
authors.lastname: Sönmez
authors.affiliation: Clinic of Urology, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Arısan
authors.affiliation: Clinic of Urology, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.
authors.forename: Soner
authors.initials: S
authors.lastname: Güney
keywords: Disease recurrence; EORTC; progression; urinary bladder neoplasm