title: The ABCDEF Bundle in Critical Care.
abstract: The ABCDEF bundle represents an evidence-based guide for clinicians to approach the organizational changes needed for optimizing intensive care unit patient recovery and outcomes. This article reviews the core evidence and features behind the ABCDEF bundle. The bundle has individual components that are clearly defined, flexible to implement, and help empower multidisciplinary clinicians and families in the shared care of the critically ill. The ABCDEF bundle helps guide well-rounded patient care and optimal resource utilization resulting in more interactive intensive care unit patients with better controlled pain, who can safely participate in higher-order physical and cognitive activities at the earliest point in their critical illness.
authors.affiliation: Center for Health Services Research, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, University of Naples Federico II, 1215 21st Avenue South, Medical Center East, Suite 6100, Nashville, TN 37232-8300, USA.
authors.forename: Annachiara
authors.initials: A
authors.lastname: Marra
authors.affiliation: VA GRECC, Center for Health Services Research, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, Suite 6109, Nashville, TN 37232-8300, USA.
authors.forename: E Wesley
authors.initials: EW
authors.lastname: Ely
authors.affiliation: Division of Anesthesiology Critical Care Medicine, Department of Anesthesiology, Center for Health Services Research, Vanderbilt University Medical Center, 1211 21st Avenue South, Medical Arts Building, Suite 526, Nashville, TN 37212, USA.
authors.forename: Pratik P
authors.initials: PP
authors.lastname: Pandharipande
authors.affiliation: Division of Trauma, Surgical Critical Care, and Emergency General Surgery, Section of Surgical Sciences, Department of Surgery, Center for Health Services Research, Vanderbilt University Medical Center, 1211 21st Avenue South, Medical Arts Building, Suite 404, Nashville, TN 37212, USA. Electronic address: mayur.b.patel@Vanderbilt.Edu.
authors.forename: Mayur B
authors.initials: MB
authors.lastname: Patel
mesh_terms: D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000628:therapy; D006801:Humans; D007362:Intensive Care Units / Q000592:standards; D064872:Patient Care Bundles / Q000379:methods; D010348:Patient Care Team
keywords: Analgesia; Delirium; Early mobility; Intensive care unit; Pain; Sedation; Spontaneous awakening trials; Spontaneous breathing trials