title: An overview of hydrogel-based intra-articular drug delivery for the treatment of osteoarthritis.
abstract: Drug administration by intra-articular injection is an emerging popular treatment for knee osteoarthritis (OA). This method of drug administration minimizes the toxic effects of the drugs administered systemically, and maximizes local effects. However, traditional oral drugs delivered via intra-articular injection are limited by the lack of sustained release. Injectable materials such as hydrogels or hydrogel microspheres have been extensively studied for their applications as intra-articular injection for the treatment of OA, which is attribute to their minimally invasive manner, extended drug retention time and high loading efficiency. In this review, we summarized hydrogel types and hydrogel characteristics for intra-articular injection, and the drugs, proteins and cells used in the injectable delivery systems. Through this review, we hope to inspire researchers to construct novel hydrogel-based delivery system for the intra-articular injection treatment of knee OA.
authors.affiliation: Department of Orthopaedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, China. Electronic address: 13913980758@163.com.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: He
authors.affiliation: Department of Orthopaedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, China. Electronic address: doct.wang@163.com.
authors.forename: Beiyue
authors.initials: B
authors.lastname: Wang
authors.affiliation: Institute of Materials Science, University of Connecticut, Storrs, CT 06269-3136, USA. Electronic address: changmin.hu@uconn.edu.
authors.forename: Changmin
authors.initials: C
authors.lastname: Hu
authors.affiliation: Department of Orthopaedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, China. Electronic address: zhaojianning.0207@163.com.
authors.forename: Jianning
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D048271:Chitosan / Q000737:chemistry; D002809:Chondroitin Sulfates / Q000008:administration & dosage; D016503:Drug Delivery Systems; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage; D020100:Hydrogels; D007270:Injections, Intra-Articular; D008863:Microspheres; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D036103:Nanotechnology; D010003:Osteoarthritis / Q000188:drug therapy*; D013256:Steroids / Q000008:administration & dosage; D023822:Tissue Engineering
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D020100:Hydrogels; D013256:Steroids; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates; D048271:Chitosan
keywords: Hydrogel-based delivery system; Intra-articular injection; Knee osteoarthritis