title: Comparative evaluation of coenzyme Q10-based gel and 0.8% hyaluronic acid gel in treatment of chronic periodontitis.
abstract: BACKGROUND
  The anti-inflammatory and immune enhancing effects of coenzyme Q10(CoQ10) and hyaluronic acid are well established in medical literature. The present study was undertaken to evaluate their role in chronic periodontitis.
  
  
  METHODS
  One hundred twenty sites in 24 patients with clinically confirmed periodontitis were included in the study. A split-mouth design was used for intrasulcular application of CoQ10as adjunct to scaling and root planing (SRP), 0.8% hyaluronic acid as adjunct to SRP and SRP alone. Clinical parameters such as plaque index (PI), gingival color change index (GCCI), Eastman interdental bleeding index (EIBI), pocket depth (PD), and clinical attachment level (CAL) were recorded. All the clinical parameters PI, EIBI, GCCI, PD, and CAL were recorded at baseline before SRP. Only PI, EIBI, and GCCI were recorded at 1stand 2ndweek. Twenty-one days post 2ndweek, i.e., 6thweek all the clinical parameters were recorded again.
  
  
  RESULTS
  Intragroup analysis of all the clinical parameters showed clinical significant results between baseline and 6thweek. However, on intergroup analysis, the results were not significant.
  
  
  CONCLUSIONS
  The local application of CoQ10and hyaluronic acid gel in conjunction with SRP may have a beneficial effect on periodontal health in patients with chronic periodontitis.
authors.affiliation: Department of Periodontics and Implantology, Himachal Institute of Dental Sciences and Research, Paonta Sahib, Sirmour, Himachal Pradesh, India.
authors.forename: Varun
authors.initials: V
authors.lastname: Sharma
authors.affiliation: Department of Periodontics and Implantology, Himachal Institute of Dental Sciences and Research, Paonta Sahib, Sirmour, Himachal Pradesh, India.
authors.forename: Rajan
authors.initials: R
authors.lastname: Gupta
authors.affiliation: Department of Periodontics and Implantology, Himachal Institute of Dental Sciences and Research, Paonta Sahib, Sirmour, Himachal Pradesh, India.
authors.forename: Parveen
authors.initials: P
authors.lastname: Dahiya
authors.affiliation: Department of Periodontics and Implantology, Himachal Institute of Dental Sciences and Research, Paonta Sahib, Sirmour, Himachal Pradesh, India.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Kumar
keywords: Chronic periodontitis; coenzyme Q10; hyaluronic acid; immunomodulators