title: Synthesis characterization and cytotoxicity studies of platinum(II) complexes with reduced amino pyridine schiff base and its derivatives as ligands.
abstract: A series of reduced amino pyridine Schiff base platinum(II) complexes were prepared as potential anticancer drugs, and characterized by NMR, IR spectroscopy, elemental analysis, and molar conductivity. UV and CD results showed the binding mode between these compounds and salmon sperm DNA may be intercalation. The cytotoxicity of these complexes was validated against A549, Hela, and MCF-7 cell lines by MTT assay. Some complexes exhibited better cytotoxic activity than cisplatin against Hela and MCF-7 cell lines.
authors.affiliation: a Chemical Biology Key Laboratory of Hebei Province , Hebei University , Baoding , P.R. China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Li
authors.affiliation: a Chemical Biology Key Laboratory of Hebei Province , Hebei University , Baoding , P.R. China.
authors.forename: Qin-Qin
authors.initials: QQ
authors.lastname: Yan
authors.affiliation: a Chemical Biology Key Laboratory of Hebei Province , Hebei University , Baoding , P.R. China.
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Liu
authors.affiliation: a Chemical Biology Key Laboratory of Hebei Province , Hebei University , Baoding , P.R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: a Chemical Biology Key Laboratory of Hebei Province , Hebei University , Baoding , P.R. China.
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Lv
authors.affiliation: a Chemical Biology Key Laboratory of Hebei Province , Hebei University , Baoding , P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Fu
authors.affiliation: a Chemical Biology Key Laboratory of Hebei Province , Hebei University , Baoding , P.R. China.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Han
authors.affiliation: a Chemical Biology Key Laboratory of Hebei Province , Hebei University , Baoding , P.R. China.
authors.forename: Jian-Long
authors.initials: JL
authors.lastname: Du
mesh_terms: D000072283:A549 Cells; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001665:Binding Sites; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D061986:MCF-7 Cells; D008297:Male; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry*; D012474:Salmon; D012545:Schiff Bases / Q000737:chemistry*; D013094:Spermatozoa / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007364:Intercalating Agents; D008024:Ligands; D009944:Organoplatinum Compounds; D011725:Pyridines; D012545:Schiff Bases; D004247:DNA
keywords: DNA interaction; antitumor activity; platinum(II) complexes; reduced amino pyridine Schiff base