title: [Comparative Assessment of Effects of Isosorbide Dinitrate, Isosorbide-5-Mononitrate and Nicorandil on the Frequency-of Angina Attacks and Vasoregulating Endothelial Function in Patients With Ischemic Heart Disease].
abstract: OBJECTIVE
  to compare effects of isosorbide dinitrate, isosorbide-5-mononitrate and nicorandil on frequency of angina attacks and vasoregulating endothelial function in patients with ischemic heart disease (IHD).
  
  
  METHODS
  In 117 patients with stable II-III functional class angina we analyzed frequency of angina attacks, exercise tolerance, data of 24-hour Holter ECG monitoring and brachial artery Doppler study.
  
  
  RESULTS
  Patients with IHD had impaired endothelium-dependent vasodilation in the form of reduced endothelial response to increase of "shear stress" during test with reactive hyperemia. Long-term therapy with isosorbide dinitrate, isosorbide-5-mononitrate, and nicorandil was associated with normalization of endothelium-dependent vasodilation of the brachial artery. This effect was more pronounced during therapy with nicorandil.
authors.affiliation: I.M. Sechenov First Moscow Medical State University, ul. Trubetskaya 8 str. 2, 119992 Moscow, Russia.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Sizova
authors.affiliation: I.M. Sechenov First Moscow Medical State University, ul. Trubetskaya 8 str. 2, 119992 Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Kozlova
authors.affiliation: I.M. Sechenov First Moscow Medical State University, ul. Trubetskaya 8 str. 2, 119992 Moscow, Russia.
authors.forename: V L
authors.initials: VL
authors.lastname: Zakharova
authors.affiliation: I.M. Sechenov First Moscow Medical State University, ul. Trubetskaya 8 str. 2, 119992 Moscow, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Shameeva