title: Trabeculectomy with Ologen versus Mitomycin C in Juvenile Open-Angle Glaucoma: A 1-Year Study.
abstract: BACKGROUND
  We assessed bleb morphology and the intraocular pressure (IOP)-lowering effect of trabeculectomy with ologen compared to mitomycin C (MMC) in juvenile open-angle glaucoma (JOAG).
  
  
  METHODS
  This is a prospective interventional comparative study conducted on 40 eyes (20 patients) with medically uncontrolled JOAG, randomly operating one eye for trabeculectomy with ologen (group A: 20 eyes) and the other with MMC (group B: 20 eyes). IOP measurement, SITA standard perimetry, and spectral domain optical coherence tomography (OCT) for retinal nerve fiber layer (RNFL) thickness were all done pre- and postoperatively. Postoperative blebs were assessed clinically using the Moorfields bleb grading system (MBGS) and anterior segment OCT (AS-OCT). All patients were examined for up to 1 year postoperatively.
  
  
  RESULTS
  The mean postoperative IOP was statistically significantly lower than the mean preoperative IOP at each follow-up in each group. At 1 year, the mean postoperative IOP was significantly lower in group A. According to the MBGS, blebs with an ologen implant showed significantly better scoring than those with MMC. AS-OCT showed that ologen-induced blebs had significantly more fluid-filled spaces, cleavage planes, and less fibrosis.
  
  
  CONCLUSIONS
  Ologen resulted in a lower long-term postoperative IOP, a better bleb morphology, and fewer complications. Our results suggest that ologen may be a useful alternative to MMC in JOAG.
authors.affiliation: Department of Ophthalmology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
authors.forename: Fathi
authors.initials: F
authors.lastname: El-Sayyad
authors.forename: Heba Magdy Ahmed
authors.initials: HMA
authors.lastname: El-Saied
authors.forename: Mohamad Amr Salah Eddin
authors.initials: MASE
authors.lastname: Abdelhakim
mesh_terms: D000293:Adolescent; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D016685:Mitomycin / Q000494:pharmacology*; D011108:Polymers; D011446:Prospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014130:Trabeculectomy / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000903:Antibiotics, Antineoplastic; D006025:Glycosaminoglycans; D011108:Polymers; C058506:collagen-glycosaminoglycan copolymer; D016685:Mitomycin; D003094:Collagen