title: Data report on inflammatory C-C chemokines among insulin-using women with diabetes mellitus and breast cancer.
abstract: Injectable insulin use may interfere with pro-inflammatory cytokines' production and, thus, play a role in the activation of tumor-associated macrophages - a process mainly influenced by inflammatory C-C chemokines. The data presented shows the relationship between pre-existing use of injectable insulin in women diagnosed with breast cancer and type 2 diabetes mellitus, the inflammatory C-C chemokine profiles at the time of breast cancer diagnosis, and subsequent cancer outcomes. A Pearson correlation analysis stratified by insulin use and controls is also provided. We present the observed relationship between the investigated C-C chemokines and between each of these biomarkers and previously reported adipokines levels in this study population [1].
authors.affiliation: State University of New York at Buffalo, Dept. of Pharmacy Practice, NYS Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, NY 14203, United States.
authors.forename: Zachary A P
authors.initials: ZA
authors.lastname: Wintrob
authors.affiliation: Cleveland Clinic, Dept. of Biostatistics and Epidemiology, 9500 Euclid Ave., Cleveland, OH 44195, United States.
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Hammel
authors.affiliation: State University of New York at Buffalo, Dept. of Pharmacy Practice, NYS Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, NY 14203, United States.
authors.forename: George K
authors.initials: GK
authors.lastname: Nimako
authors.affiliation: State University of New York at Buffalo, Dept. of Pharmacy Practice, NYS Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, NY 14203, United States.
authors.forename: Zahra S
authors.initials: ZS
authors.lastname: Fayazi
authors.affiliation: State University of New York at Buffalo, Dept. of Biostatistics, 718 Kimball Tower, Buffalo, NY 14214, United States.
authors.forename: Dan P
authors.initials: DP
authors.lastname: Gaile
authors.affiliation: State University of New York at Buffalo, Dept. of Pharmacy Practice, NYS Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, NY 14203, United States.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Davis
authors.affiliation: The UNC Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics, Campus Box 7569, Chapel Hill, NC 27599, United States.
authors.forename: Alan
authors.initials: A
authors.lastname: Forrest
authors.affiliation: State University of New York at Buffalo, Dept. of Pharmacy Practice, NYS Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, NY 14203, United States; Roswell Park Cancer Institute, Dept. of Pharmacy Services, Elm & Carlton Streets, Buffalo, NY 14263, United States.
authors.forename: Alice C
authors.initials: AC
authors.lastname: Ceacareanu
keywords: Breast cancer; C-C chemokines; CCL-2; CCL-3; CCL-4; CCL-5; Cancer prognosis; Diabetes; Inflammation; Inflammatory cytokines; Insulin; Tumor-associated macrophages