title: Sleep regulation of the distribution of cortical firing rates.
abstract: Sleep is thought to mediate both mnemonic and homeostatic functions. However, the mechanism by which this brain state can simultaneously implement the 'selective' plasticity needed to consolidate novel memory traces and the 'general' plasticity necessary to maintain a well-functioning neuronal system is unclear. Recent findings show that both of these functions differentially affect neurons based on their intrinsic firing rate, a ubiquitous neuronal heterogeneity. Furthermore, they are both implemented by the NREM slow oscillation, which also distinguishes neurons based on firing rate during sequential activity at the DOWN→UP transition. These findings suggest a mechanism by which spiking activity during the slow oscillation acts to maintain network statistics that promote a skewed distribution of neuronal firing rates, and perturbation of that activity by hippocampal replay acts to integrate new memory traces into the existing cortical network.
authors.affiliation: New York University Neuroscience Institute, New York University, New York, NY 10016, United States; Center for Neural Science, New York University, New York, NY 10003, United States.
authors.forename: Daniel
authors.initials: D
authors.lastname: Levenstein
authors.affiliation: New York University Neuroscience Institute, New York University, New York, NY 10016, United States.
authors.forename: Brendon O
authors.initials: BO
authors.lastname: Watson
authors.affiliation: Center for Neural Science, New York University, New York, NY 10003, United States; Courant Institute of Mathematical Sciences, New York University, New York, NY 10012, United States. Electronic address: rinzeljm@gmail.com.
authors.forename: John
authors.initials: J
authors.lastname: Rinzel
authors.affiliation: New York University Neuroscience Institute, New York University, New York, NY 10016, United States; Center for Neural Science, New York University, New York, NY 10003, United States. Electronic address: gyorgy.buzsaki@nyumc.org.
authors.forename: György
authors.initials: G
authors.lastname: Buzsáki
mesh_terms: D002540:Cerebral Cortex / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D008568:Memory / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D012890:Sleep / Q000502:physiology*