title: [Clinical and Economic Efficacy of Ivabradine in Patients Suffered Myocardial Infarction].
abstract: OBJECTIVE
  to assess the clinical and cost-effectiveness of the addition to the treatment of patients with coronary artery disease, myocardial infarction (MI) If current blocker ivabradine.
  
  
  METHODS
  as a basis for pharmacoeconomic research results of the program are taken battleships, in which 1226 patients with MI less than 12 months ago, for 16 weeks received ivabradine in addition to standard therapy. When conducting pharmacoeconomic calculations take into account the direct medical and non-medical costs of treating patients with drugs; the call ambulance crews (CAC); on the patients stay in the hospital at admission. To determine the cost of use of ivabradine used data on daily dosages of the drug presented in the program battleships. In this case, using the retail price of drugs taken from the resource pharmindex.ru (date accessed 6/23/14). When calculating the cost of hospitalization and emergency calls using the values specified in the decree of october 18, 2013 No932 "About the state guarantees the free provision of medical care to citizens for 2014 and the planning period of 2015 and 2016.".
  
  
  RESULTS
  according to a study LINCOR adding ivabradine to standard therapy resulted in a significant reduction in the frequency of angina attacks, the need for treatment for CACs and hospitalization. Average total cost of a full 16-week course of therapy with a patient ivabradine 1.87 times lower than with the standard therapy alone. The most obvious benefits to health care institutions: the total cost of emergency calls and hospitalization when added to treatment with ivabradine reduced 20 027.79 to 1,630.45 rubles., Ie 12.3 times.
  
  
  CONCLUSIONS
  despite the increase in direct costs due to the cost of the drug, the addition to the standard therapy of ivabradine in patients with myocardial infarction, pharmaco is more effective than using only standard therapy, due to a significant reduction in the need for emergency calls and hospitalization.
authors.affiliation: Research Institute of Vaccines and Sera. I.I. Mechnikov Medical Sciences , Dubrovskaya 1-st str., 15, bild 1, 115088 Moscow, Russia; I.M. Sechenov First Moscow Medical State University, 8, bild. 2, Trubetckay, 119992 Moscow, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: Dyakov
authors.affiliation: Research Institute of Vaccines and Sera. I.I. Mechnikov Medical Sciences , Dubrovskaya 1-st str., 15, bild 1, 115088 Moscow, Russia; I.M. Sechenov First Moscow Medical State University, 8, bild. 2, Trubetckay, 119992 Moscow, Russia.
authors.forename: M G
authors.initials: MG
authors.lastname: Gleser