title: Positive Association between Urinary Concentration of Phthalate Metabolites and Oxidation of DNA and Lipid in Adolescents and Young Adults.
abstract: Phthalate has been used worldwide in various products for years. Little is known about the association between phthalate exposure and biomarkers of oxidative stress in adolescents and young adults. Among 886 subjects recruited from a population-based cohort during 2006 to 2008, 751 subjects (12-30 years) with complete phthalate metabolites and oxidation stress measurement were enrolled in this study. Nine urine phthalate metabolites, 8-hydroxydeoxyguanosine (8-OHdG), and 8-iso prostaglandin F2α (8-isoPGF2α) were measured in urine to assess exposure and oxidative stress to DNA and lipid, respectively. Multiple linear regression analysis revealed that an ln-unit increase in mono-methyl phthalate (MMP) concentration in urine was positively associated with an increase in urine biomarkers of oxidative stress (in μg/g; creatinine of 0.098 ± 0.028 in 8-OHdG; and 0.253 ± 0.051 in 8-isoPGF2α). There was no association between other eight phthalate metabolite concentrations and oxidative stress. In conclusion, a higher MMP concentration in urine was associated with an increase in markers of oxidative stress to DNA and lipid in this cohort of adolescents and young adults. Further studies are warranted to clarify the causal relationship between exposure to phthalate and oxidative stress.
authors.affiliation: Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan.|School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan.
authors.forename: Chien-Yu
authors.initials: CY
authors.lastname: Lin
authors.affiliation: Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei 100, Taiwan.|Department of Public Health, College of Public Health, National Taiwan University, Taipei 100, Taiwan.|Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei 100, Taiwan.
authors.forename: Pau-Chung
authors.initials: PC
authors.lastname: Chen
authors.affiliation: Department of Public Health, Tzu Chi University, Hualian County 970, Taiwan.
authors.forename: Chia-Jung
authors.initials: CJ
authors.lastname: Hsieh
authors.affiliation: Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan.
authors.forename: Chao-Yu
authors.initials: CY
authors.lastname: Chen
authors.affiliation: Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualian County 970, Taiwan.
authors.forename: Anren
authors.initials: A
authors.lastname: Hu
authors.affiliation: Department of Health Services Administration, College of Public Health, China Medical University, Taichung 404, Taiwan.
authors.forename: Fung-Chang
authors.initials: FC
authors.lastname: Sung
authors.affiliation: Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Lee
authors.affiliation: Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei 100, Taiwan.|Department of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital, Taipei 100, Taiwan.
authors.forename: Ta-Chen
authors.initials: TC
authors.lastname: Su
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000652:urine; D001711:Biotransformation; D002648:Child; D015331:Cohort Studies; D004247:DNA / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000652:urine; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000652:urine; D005260:Female; D006801:Humans; D016014:Linear Models; D015227:Lipid Peroxidation; D008297:Male; D018384:Oxidative Stress; D010795:Phthalic Acids / Q000652:urine*; D013624:Taiwan
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D010795:Phthalic Acids; C075750:8-epi-prostaglandin F2alpha; C517284:monomethyl phthalate; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D015237:Dinoprost; D003849:Deoxyguanosine