title: Probiotics are a good choice in remission of inflammatory bowel diseases: A meta analysis and systematic review.
abstract: Altered gut bacteria and bacterial metabolic pathways are two important factors in initiation and progression of inflammatory bowel disease (IBD). However, efficacy of probiotics in remission of patients with IBD has not been characterized. This study was performed on the studies that specifically assessed the efficacy of probiotics in attaining clinical response on patients with various types of IBD. The efficacy of variant species of probiotics in different conditions and the influence of study quality in outcomes of randomized controlled trials (RCTs) were also assessed. The RCTs were collected by searching in MEDLINE Web of Science and Google scholar. Then all studies were abstracted in abstraction form and the outcomes were analyzed with fixed-effect and mixed-effect models for assessment of efficacy of variant species of probiotics in subgroups of IBDs. Analysis of 9 trials showed that probiotics had not significant effect on Crohn's disease (CD) (p = 0.07) but analysis of 3 trials in children with IBD revealed a significant advantage (p < 0.01). Analysis of 18 trials revealed that probiotics in patients with Ulcerative colitis (UC) in different conditions have significant effects (p = 0.007). VSL#3 probiotics in patients with UC had significant effect (p < 0.01). Combination of Lactobacillus probiotic, prebiotics had significant effect (p = 0.03) only in patients with UC. Combination of Saccharomyces boulardii, Lactobacillus, and VSL#3 probiotics in CD had also a trend for efficiency (p = 0.057). In children with IBD, the combination of Lactobacillus with VSL#3 probiotics had significant effect (p < 0.01). Probiotics are beneficial in IBD, especially the combination ones in UC.
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Mahboube
authors.initials: M
authors.lastname: Ganji-Arjenaki
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Mahmoud
authors.identifier: http://orcid.org/0000-0002-1325-0274
authors.initials: M
authors.lastname: Rafieian-Kopaei
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003093:Colitis, Ulcerative / Q000382:microbiology / Q000628:therapy*; D003424:Crohn Disease / Q000382:microbiology / Q000628:therapy*; D004926:Escherichia coli; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans; D007778:Lactobacillus; D008875:Middle Aged; D056692:Prebiotics / Q000382:microbiology; D019936:Probiotics / Q000627:therapeutic use*; D000069983:Saccharomyces boulardii; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D056692:Prebiotics
keywords: Crohn's disease; IBD; probiotics; ulcerative colitis