title: Donor age matters in T-cell depleted haploidentical hematopoietic stem cell transplantation in pediatric patients: Faster immune reconstitution using younger donors.
abstract: T-cell depleted (TCD) haploidentical transplantation is increasingly used in paediatric patients with haematological malignancies and donor selection is a challenge. We conclude that a simple criterion such as donor age should be also considered in depleted haploidentical setting because faster immune reconstitution is achieved using younger donors decreasing non-relapse related mortality.
authors.affiliation: Stem Cell Transplant Unit, Hospital Niño Jesus, Madrid, Spain. Electronic address: mgonzalezv.hnjs@salud.madrid.org.
authors.forename: Marta
authors.initials: M
authors.lastname: González-Vicent
authors.affiliation: Stem Cell Transplant Unit, Hospital Niño Jesus, Madrid, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Molina
authors.affiliation: Stem Cell Transplant Unit, Hospital Niño Jesus, Madrid, Spain.
authors.forename: Natalia
authors.initials: N
authors.lastname: Deltoro
authors.affiliation: Blood Bank, Hospital Niño Jesus, Madrid, Spain.
authors.forename: Julián
authors.initials: J
authors.lastname: Sevilla
authors.affiliation: Histocompatibility Laboratory, Community Transfusion Center, Madrid, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Vicario
authors.affiliation: Oncology Laboratory, Hospital Niño Jesus, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Castillo
authors.affiliation: Oncology Laboratory, Hospital Niño Jesus, Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Ramirez
authors.affiliation: Stem Cell Transplant Unit, Hospital Niño Jesus, Madrid, Spain.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Díaz
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001782:Blood Donors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival / Q000276:immunology*; D006239:Haplotypes; D019337:Hematologic Neoplasms / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007223:Infant; D008212:Lymphocyte Depletion; D008297:Male; D055815:Young Adult
keywords: Donor age; HSCT; Haploidentical; Immune reconstitution; Pediatric; T-cell depletion