title: The effects of histones H1o, H5 and HMG proteins on cell division of cultured murine erythroleukemia cells.
abstract: In the present study the effect of histones H1oand H5, and the nonhistone chromatin proteins HMG 1, 2, 14 and 17 (the high mobility group proteins), as well as the acidic peptide fragments of HMG 1 and 2 and polyglutamate, on cell division and differentation of cultured murine erythroleukemia (Friend) cells has been investigated. It was found that histones H1oand H5, the acidic peptide fragments of HMG 1 and 2, HMG 14 and 17 and sodium polyglutamate stimulated cell division at a concentration of 10 μg/ml. None of the H1o, H5 or HMG protein preparations induced hemoglobin synthesis, as judged by benzidine staining.
authors.affiliation: Department of Biological Sciences, State University of New York, 14226, Buffalo, New York, USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Richman
authors.affiliation: MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, Scotland.
authors.forename: Keith
authors.initials: K
authors.lastname: Gooderham
authors.affiliation: Department of Biological Sciences, State University of New York, 14226, Buffalo, New York, USA.
authors.forename: Reed
authors.initials: R
authors.lastname: Flickinger
keywords: Cell division; HMG proteins; Histones