title: Reactive Arthritis.
abstract: Reactive arthritis is classified as a spondyloarthropathy. Current concepts of disease suggest an infectious trigger, followed by inflammatory arthritis. Several mechanisms have been proposed to explain the interaction of host susceptibility and microorganism. Diagnosis relies on a compatible clinical syndrome and microbiologic confirmation of the pathogen. Antibiotic therapy seems useful in Chlamydia-triggered arthritis. The role of antibiotics in arthritis triggered by enteric pathogens is less clear. The role of tumor necrosis factor alpha inhibitors in therapy is evolving. Many patients have a course limited to a few months, but others experience extraarticular disease and more prolonged courses.
authors.affiliation: Section of Bone and Joint Infections, Department of Infectious Disease, Medicine Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Desk G-21, Cleveland, OH 44195, USA. Electronic address: schmits@ccf.org.
authors.forename: Steven K
authors.initials: SK
authors.lastname: Schmitt
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016918:Arthritis, Reactive / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology* / Q000503:physiopathology; D002169:Campylobacter Infections / Q000150:complications / Q000188:drug therapy; D002690:Chlamydia Infections / Q000150:complications / Q000188:drug therapy; D004405:Dysentery, Bacillary / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D012480:Salmonella Infections / Q000150:complications / Q000188:drug therapy; D015009:Yersinia Infections / Q000150:complications / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents
keywords: Campylobacter; Chlamydia; Inflammatory arthritis; Reactive arthritis; Salmonella; Shigella; Spondyloarthropathy; Yersinia