title: Pathophysiology of trauma-induced coagulopathy: disseminated intravascular coagulation with the fibrinolytic phenotype.
abstract: In severe trauma patients, coagulopathy is frequently observed in the acute phase of trauma. Trauma-induced coagulopathy is coagulopathy caused by the trauma itself. The pathophysiology of trauma-induced coagulopathy consists of coagulation activation, hyperfibrino(geno)lysis, and consumption coagulopathy. These pathophysiological mechanisms are the characteristics to DIC with the fibrinolytic phenotype.
authors.affiliation: Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, Sapporo, 060-8648 Japan.
authors.forename: Mineji
authors.initials: M
authors.lastname: Hayakawa
keywords: Coagulopathy; Disseminated intravascular coagulation; Fibrinogen; Fibrinolysis; Massive bleeding; Transfusion; Trauma