title: An NIR-emitting lysosome-targeting probe with large Stokes shift via coupling cyanine and excited-state intramolecular proton transfer.
abstract: An NIR-emitting probe (λem∼ 700 nm) with a large Stokes shift (Δλ ≈ 234 nm) is synthesized by using excited-state intramolecular proton transfer (ESIPT). The phenolic proton, which controls ESIPT, acts as a switch to give strong fluorescence at pH ≈ 5. The probe can selectively show lysosome organelles, therefore leading to a lysosome probe without exhibiting "an alkalinizing effect".
authors.affiliation: Department of Chemistry, University of Akron, Akron, Ohio 44325, USA. yp5@uakron.edu.
authors.forename: Dipendra
authors.initials: D
authors.lastname: Dahal
authors.affiliation: Department of Chemistry, University of Akron, Akron, Ohio 44325, USA. yp5@uakron.edu.
authors.forename: Lucas
authors.initials: L
authors.lastname: McDonald
authors.affiliation: Department of Chemistry, University of Akron, Akron, Ohio 44325, USA. yp5@uakron.edu.
authors.forename: Xiaoman
authors.initials: X
authors.lastname: Bi
authors.affiliation: Department of Chemistry, University of Akron, Akron, Ohio 44325, USA. yp5@uakron.edu.
authors.forename: Chathura
authors.initials: C
authors.lastname: Abeywickrama
authors.affiliation: Department of Chemistry, University of Akron, Akron, Ohio 44325, USA. yp5@uakron.edu.
authors.forename: Farai
authors.initials: F
authors.lastname: Gombedza
authors.affiliation: Department of Chemistry, University of Akron, Akron, Ohio 44325, USA. yp5@uakron.edu.
authors.forename: Michael
authors.identifier: http://orcid.org/0000-0002-2194-6300
authors.initials: M
authors.lastname: Konopka
authors.affiliation: Department of Chemistry, University of Akron, Akron, Ohio 44325, USA. yp5@uakron.edu.
authors.forename: Sailaja
authors.initials: S
authors.lastname: Paruchuri
authors.affiliation: Department of Chemistry, University of Akron, Akron, Ohio 44325, USA. yp5@uakron.edu.
authors.forename: Yi
authors.identifier: http://orcid.org/0000-0001-7275-4563
authors.initials: Y
authors.lastname: Pang