title: Fluconazole Doses Used for Prophylaxis of Invasive Fungal Infection in Neonatal Intensive Care Units: A Network Meta-Analysis.
abstract: To evaluate the safety and efficacy of different doses of fluconazole used for invasive prophylaxis of fungal infection in neonates.
  
  
  
  A systematic search was conducted with PubMed, Scopus, and Web of Science. A manual search was performed as well. Only randomized controlled trials of neonates in a neonatal intensive care unit (NICU) who received fluconazole prophylaxis for invasive fungal infection, regardless of the dose or therapeutic regimen, were included in this review. Data on baseline characteristics, outcomes incidence of proven invasive Candida infection, overall mortality, and invasive Candida infection-related mortality were extracted.
  
  
  
  Eleven studies were included in the review, with fluconazole doses of 3, 4, or 6?mg/kg. When the incidence of invasive Candida and invasive Candida-related mortality were considered as outcomes, the 3 and 6?mg/kg fluconazole doses were found to be statistically superior to placebo (OR, 5.48 [95% credible interval, 1.81-18.94] and 2.63 [1.18-7.02], respectively, and 15.32 [1.54-54.31] and 9.14 [1.26-142.7], respectively), but data for the 3 doses were not statistically significantly different.
  
  
  
  Use of the lowest fluconazole dose (3?mg/kg) should be recommended for Candida prophylaxis in neonates, given that increasing the fluconazole dose is not associated with higher efficacy and has greater potential for toxicity and increased cost.
authors.affiliation: Department of Pharmacy, Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors.forename: Letícia Paula
authors.initials: LP
authors.lastname: Leonart
authors.affiliation: Department of Pharmacy, Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors.forename: Fernanda Stumpf
authors.initials: FS
authors.lastname: Tonin
authors.affiliation: Department of Pharmacy, Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors.forename: Vinicius Lins
authors.initials: VL
authors.lastname: Ferreira
authors.affiliation: Department of Pharmacy, Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors.forename: Suelem
authors.initials: S
authors.lastname: Tavares da Silva Penteado
authors.affiliation: Pelé Pequeno Príncipe Research Institute, Pequeno Príncipe Hospital, Curitiba, PR, Brazil.
authors.forename: Fábio
authors.initials: F
authors.lastname: de Araújo Motta
authors.affiliation: Department of Pharmacy, Universidade Federal do Paraná, Curitiba, PR, Brazil. Electronic address: pontarolo@ufpr.br.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pontarolo
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage*; D058365:Candidiasis, Invasive / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D015725:Fluconazole / Q000008:administration & dosage*; D006801:Humans; D007363:Intensive Care Units, Neonatal
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole
keywords: dose; fluconazole; neonate, preterm infant; prophylaxis