title: The maternal serum thiol/disulfide homeostasis is impaired in pregnancies complicated by idiopathic intrauterine growth restriction.
abstract: OBJECTIVE
  To investigate the maternal serum thiol/disulfide homeostasis in pregnancies complicated by idiopathic intrauterine growth restriction (IUGR) and to compare the results with healthy pregnancies.
  
  
  METHODS
  This descriptive cohort study included 55 pregnant women complicated by idiopathic IUGR and 57 similar gestational aged healthy pregnant women in the third trimester of gestation. Maternal serum samples were collected at the day of diagnosis and the thiol/disulfide homeostasis was measured by using an automated assay method. The patients were followed up until delivery and perinatal outcomes were recorded.
  
  
  RESULTS
  Maternal serum native thiol (308.1 ± 40.7 μmol/L vs. 282.4 ± 60.6 μmol/L) and total thiol (346.8 ± 48.1 μmol/L vs. 324.0 ± 62.2 μmol/L) concentrations were significantly lower in IUGR group compared with healthy controls (p: .010 and p: .032, respectively), whereas disulfide (19.3 ± 8.7 μmol/L vs. 20.8 ± 7.8 μmol/L) concentrations were similar between the groups (p: .350). Maternal serum disulfide/native thiol and disulfide/total thiol ratios were higher in IUGR group compared with healthy controls (p: .014 and p: .017, respectively), whereas native thiol/total thiol ratio was significantly lower in IUGR group compared with healthy controls (p: .016).
  
  
  CONCLUSIONS
  This study suggests that there is an impaired maternal thiol/disulfide homeostasis in pregnancies complicated by idiopathic IUGR during the third trimester of gestation.
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Orkun
authors.initials: O
authors.lastname: Cetin
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Erbil
authors.initials: E
authors.lastname: Karaman
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Boza
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Numan
authors.initials: N
authors.lastname: Cim
authors.affiliation: b Department of Biochemistry, Faculty of Medicine , Yıldırım Beyazıt University , Ankara , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Alisik
authors.affiliation: b Department of Biochemistry, Faculty of Medicine , Yıldırım Beyazıt University , Ankara , Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Kolusarı
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Hanım Guler
authors.initials: HG
authors.lastname: Sahin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004220:Disulfides / Q000097:blood*; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000175:diagnosis; D005500:Follow-Up Studies; D006706:Homeostasis; D006801:Humans; D018384:Oxidative Stress; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood; D012680:Sensitivity and Specificity; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D015415:Biomarkers; D004220:Disulfides; D013438:Sulfhydryl Compounds
keywords: Maternal serum; intrauterine growth restriction; pregnancy; thiol/disulfide homeostasis