title: A Rapid Method for the Quantitative Determination of 34 Pesticides in Nonalcoholic Carbonated Beverages Using Liquid-Liquid Extraction Coupled to Dispersive Solid-Phase Cleanup Followed by Gas Chromatography with Tandem Mass Spectrometry.
abstract: An economical, rapid, and sensitive multiresidue method using liquid-liquid extraction (LLE) coupled with dispersive SPE (dSPE) cleanup was developed for the quantitative determination of 34 multiclass multiresidue (MCMR) pesticides (14 organochlorines, eight organophosphates, 10 synthetic pyrethroids, and two herbicides) in nonalcoholic carbonated beverages (cola, orange, lemon-lime, and citra) using GC with tandem MS. The procedure mainly involved LLE by dichloromethane and dSPE cleanup in the presence of magnesium sulfate, primary secondary amine, and C18. The RSD of the developed method was found to be less than 14%. The LOD and LOQ values for all the analyzed pesticides were found in the ranges of 0.001-0.027 μg/L and 0.004-0.088 μg/L, respectively. The LOQ levels of the pesticides analyzed were found to be well below the recommended limit by the European Union (0.1 μg/L in water). The mean recoveries of pesticides in different nonalcoholic carbonated beverages (cola, orange, lemon-lime, and citra) were found to be in the range of 79-111%, with RSDs less than 11%. The validation data prove that the method can be acceptable to regulatory agencies for the routine analysis of MCMR pesticides in nonalcoholic carbonated beverages.
authors.affiliation: Council of Scientific and Industrial Research-Indian Institute of Toxicology Research, Regulatory Toxicology Group, Pesticide Toxicology Laboratory, Vish Vigyan Bhavan MG Marg, Lucknow 226 001, Uttar Pradesh, India.
authors.forename: Satyajeet
authors.initials: S
authors.lastname: Rai
authors.affiliation: Council of Scientific and Industrial Research-Indian Institute of Chemical Technology, Analytical Chemistry and Mass Spectrometry Division, Chromatography Unit, Tarnaka, Uppal Rd, Hyderabad 500 007, Telangana, India.
authors.forename: Madhuri Devi
authors.initials: MD
authors.lastname: Gullapalli
authors.affiliation: Council of Scientific and Industrial Research-Indian Institute of Toxicology Research, Regulatory Toxicology Group, Pesticide Toxicology Laboratory, Vish Vigyan Bhavan MG Marg, Lucknow 226 001, Uttar Pradesh, India.
authors.forename: Anshuman
authors.initials: A
authors.lastname: Srivastava
authors.affiliation: Council of Scientific and Industrial Research-Indian Institute of Chemical Technology, Analytical Chemistry and Mass Spectrometry Division, Chromatography Unit, Tarnaka, Uppal Rd, Hyderabad 500 007, Telangana, India.
authors.forename: Hussain
authors.initials: H
authors.lastname: Shaik
authors.affiliation: Integral University, Department of Bioengineering, Lucknow 226 026, Uttar Pradesh, India.
authors.forename: Mohammed Haris
authors.initials: MH
authors.lastname: Siddiqui
authors.affiliation: Council of Scientific and Industrial Research-Indian Institute of Chemical Technology, Analytical Chemistry and Mass Spectrometry Division, Chromatography Unit, Tarnaka, Uppal Rd, Hyderabad 500 007, Telangana, India.
authors.forename: Mohana Krishna Reddy
authors.initials: MKR
authors.lastname: Mudiam
mesh_terms: D002253:Carbonated Beverages / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D059625:Liquid-Liquid Extraction; D010573:Pesticide Residues / Q000032:analysis*; D052616:Solid Phase Extraction; D053719:Tandem Mass Spectrometry
chemical_list: D010573:Pesticide Residues