title: Helicobacter pyloriinfection with intestinal metaplasia: An independent risk factor for colorectal adenomas.
abstract: OBJECTIVE
  To explore the association betweenHelicobacter pylori(H. pylori) infection status, intestinal metaplasia (IM), and colorectal adenomas.
  
  
  METHODS
  We retrospectively reviewed 1641 individuals aged ≥ 40 years who underwent physical examination, laboratory testing,13C-urea breath testing, gastroscopy, colonoscopy, and an interview to ascertain baseline characteristics and general state of health. Histopathological results were obtained by gastric and colorectal biopsies.
  
  
  RESULTS
  The prevalence ofH. pyloriinfection and adenomas was 51.5% (845/1641) and 18.1% (297/1641), respectively.H. pyloriinfection was significantly correlated with an increased risk of colorectal adenomas (crude OR = 1.535, 95%CI: 1.044-1.753,P= 0.022; adjusted OR = 1.359, 95%CI: 1.035-1.785,P= 0.028). Individuals with IM had an elevated risk of colorectal adenomas (crude OR = 1.664, 95%CI: 1.216-2.277,P= 0.001; adjusted OR = 1.381, 95%CI: 0.998-1.929,P= 0.059). Stratification based onH. pyloriinfection stage and IM revealed that IM accompanied byH. pyloriinfection was significantly associated with an increased risk of adenomas (crude OR = 2.109, 95%CI: 1.383-3.216,P= 0.001; adjusted OR = 1.765, 95%CI: 1.130-2.757,P= 0.012).
  
  
  CONCLUSIONS
  H. pylori-related IM is associated with a high risk of colorectal adenomas in Chinese individuals.
authors.affiliation: Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Yi-Na
authors.initials: YN
authors.lastname: Chen
authors.affiliation: Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Chun-Jing
authors.initials: CJ
authors.lastname: Lin
authors.affiliation: Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Pan
authors.affiliation: Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Jian-Sheng
authors.initials: JS
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001944:Breath Tests; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D007422:Intestines / Q000382:microbiology* / Q000473:pathology*; D008679:Metaplasia / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D008875:Middle Aged; D015995:Prevalence; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D013270:Stomach / Q000473:pathology; D016896:Treatment Outcome
keywords: Chinese population; Chronic gastritis; Colorectal neoplasms; Helicobacter pylori; Intestinal metaplasia