title: Comparative study of autologous fat vs hyaluronic acid in correction of the nasolabial folds.
abstract: OBJECTIVE
  In the article, comparison of the hyaluronic acid (HA) and autologous fat is conducted to evaluate the effectiveness and safety in correction of the nasolabial folds (NLFs).
  
  
  METHODS
  From November 2012 to December 2015, a single-blinded, randomized study was conducted. Sixty-two patients were included in the study, and 57 of them completed the whole procedure. The patients were randomly allocated to receive the treatments of HA or fat in both NLFs. The Wrinkle Severity Rating Scale (WSRS) and Global Aesthetic Improvement Scale (GAIS) were used for assessment. Efficacy was assessed using two parameters: evaluation of final improvement by blinded evaluator and patient-self using photographs. The effectiveness endpoint was improvement of scores at 1, 3, 6, 9, and 12 months from baseline. The adverse events (AEs) were recorded.
  
  
  RESULTS
  In the blinded evaluator scores for NLF in accordance with WSRS, there were no significant differences between the two methods within 9 months. A statistically significant difference between the lipoinjection and HA groups was found at 12-month follow-up period. Subjects' self-assessment was similar to the results seen for the evaluator scores. The difference of AEs between the HA and fat group was obvious in the early stage of recovery. In the later stage, the AEs of the HA and fat group were similar.
  
  
  CONCLUSIONS
  Both HA gel and autologous fat provide augmentation of NLFs. The magnitude and duration of NLF correction appear to be similarly effective and safe within a period.
authors.affiliation: Plastic Surgery Department, China Japan Friendship Hospital, Beijing, China.
authors.forename: Xiaogen
authors.initials: X
authors.lastname: Hu
authors.affiliation: Plastic Surgery Department, China Japan Friendship Hospital, Beijing, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Xue
authors.affiliation: Plastic Surgery Department, China Japan Friendship Hospital, Beijing, China.
authors.forename: Huijie
authors.initials: H
authors.lastname: Qi
authors.affiliation: Plastic Surgery Department, China Japan Friendship Hospital, Beijing, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000067548:Dermal Fillers / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D060052:Nasolabial Fold; D015361:Rhytidoplasty / Q000009:adverse effects / Q000379:methods*; D016037:Single-Blind Method; D015595:Skin Aging; D050151:Subcutaneous Fat / Q000637:transplantation*; D013997:Time Factors; D014182:Transplantation, Autologous / Q000009:adverse effects
chemical_list: D000067548:Dermal Fillers; D006820:Hyaluronic Acid
keywords: clinical research; facial rejuvenation; fat injections; filler