title: E6/E7-P53-POU2F1-CTHRC1 axis promotes cervical cancer metastasis and activates Wnt/PCP pathway.
abstract: Cervical cancer is an infectious cancer and the most common gynecologic cancer worldwide. E6/E7, the early genes of the high-risk mucosal human papillomavirus type, play key roles in the carcinogenic process of cervical cancer. However, little was known about its roles in modulating tumor microenvironment, particular extracellular matrix (ECM). In this study, we found that E6/E7 could regulate multiple ECM proteins, especially collagen triple helix repeat containing 1 (CTHRC1). CTHRC1 is highly expressed in cervical cancer tissue and serum and closely correlated with clinicopathological parameters. CTHRC1 promotes cervical cancer cell migration and invasion in vitro and metastasis in vivo. E6/E7 regulates the expression of CTHRC1 in cervical cancer by E6/E7-p53-POU2F1 (POU class 2 homeobox 1) axis. Futhermore, CTHRC1 activates Wnt/PCP signaling pathway. Take together, E6/E7-p53-POU2F1-CTHRC1 axis promotes cervical cancer cell invasion and metastasis and may act as a potential therapeutic target for interventions against cervical cancer invasion and metastasis.
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University, Shanghai 201499, China.|Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University, Shanghai 201499, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University, Shanghai 201499, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Lyu
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University, Shanghai 201499, China.
authors.forename: Lin-Yan
authors.initials: LY
authors.lastname: Zhu
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University, Shanghai 201499, China.
authors.forename: Guang-Dong
authors.initials: GD
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, Changzhou NO. 2 People's Hospital, Jiangsu 213003, China.
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Jiang
authors.affiliation: Changzhou Maternal And Child Health Care Hospital, Jiangsu 213003, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Re
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University, Shanghai 201499, China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Song
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University, Shanghai 201499, China.
authors.forename: Jin-Hao
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Jinzhou Medical University, Liaoning 121001, China.
authors.forename: Can-Can
authors.initials: CC
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Fengxian Hospital, Southern Medical University, Shanghai 201499, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Gu
authors.affiliation: Jinzhou Medical University, Liaoning 121001, China.
authors.forename: Tian-Jiao
authors.initials: TJ
authors.lastname: Luo
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Wu
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.|Department of Obstetrics and Gynecology of Shanghai Medical College, Fudan University, Shanghai 200032, China.|Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China.|Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China.|Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
authors.forename: Cong-Jian
authors.initials: CJ
authors.lastname: Xu
mesh_terms: D002465:Cell Movement / Q000235:genetics; D016764:Cell Polarity; D049109:Cell Proliferation / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D050811:Octamer Transcription Factor-1 / Q000378:metabolism*; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D012372:ROC Curve; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D015854:Up-Regulation / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D060449:Wnt Signaling Pathway
chemical_list: C502426:CTHRC1 protein, human; D016326:Extracellular Matrix Proteins; D050811:Octamer Transcription Factor-1; D009856:Oncogene Proteins, Viral; C494165:POU2F1 protein, human; D016159:Tumor Suppressor Protein p53