title: GEAR: A database of Genomic Elements Associated with drug Resistance.
abstract: Drug resistance is becoming a serious problem that leads to the failure of standard treatments, which is generally developed because of genetic mutations of certain molecules. Here, we present GEAR (A database of Genomic Elements Associated with drug Resistance) that aims to provide comprehensive information about genomic elements (including genes, single-nucleotide polymorphisms and microRNAs) that are responsible for drug resistance. Right now, GEAR contains 1631 associations between 201 human drugs and 758 genes, 106 associations between 29 human drugs and 66 miRNAs, and 44 associations between 17 human drugs and 22 SNPs. These relationships are firstly extracted from primary literature with text mining and then manually curated. The drug resistome deposited in GEAR provides insights into the genetic factors underlying drug resistance. In addition, new indications and potential drug combinations can be identified based on the resistome. The GEAR database can be freely accessed through http://gear.comp-sysbio.org.
authors.affiliation: Department of Computer Science and Technology, Tongji University, Shanghai 201804, China.|Department of Electronic Engineering, City University of Hong Kong, Kowloon 999077, Hong Kong.
authors.forename: Yin-Ying
authors.initials: YY
authors.lastname: Wang
authors.affiliation: Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, Hubei 430074, China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Chen
authors.affiliation: Department of Computer Science and Technology, Tongji University, Shanghai 201804, China.
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Xiao
authors.affiliation: Department of Computer Science and Technology, Tongji University, Shanghai 201804, China.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Xie
authors.affiliation: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
authors.forename: Qibin
authors.initials: Q
authors.lastname: Luo
authors.affiliation: European Molecular Biology Laboratory (EMBL), Heidelberg, 69117, Germany.
authors.forename: Peer
authors.initials: P
authors.lastname: Bork
authors.affiliation: Department of Computer Science and Technology, Tongji University, Shanghai 201804, China.
authors.forename: Xing-Ming
authors.initials: XM
authors.lastname: Zhao
mesh_terms: D016000:Cluster Analysis; D030541:Databases, Genetic; D004351:Drug Resistance; D016678:Genome; D006801:Humans; D009154:Mutation