title: Etiology of End-Stage Renal Disease and Arterial Stiffness among Hemodialysis Patients.
abstract: Background. Prior studies have demonstrated that conventional and emerging CV risk factors are associated with worsening arterial stiffness among end-stage renal disease (ESRD) patients on hemodialysis. The present cross-sectional study evaluates the association between the etiology of ESRD and arterial stiffness among a cohort of hemodialysis patients.Methods. Etiology of ESRD was identified from patients' medical records and classified as either vascular renal disease, diabetic nephropathy, nondiabetic glomerulopathy, tubular interstitial nephropathy, hereditary nephropathy, or ESRD of unconfirmed etiology.Results. A total of 82 subjects were enrolled. cfPWV was independently associated with the composite of either diabetic nephropathy or vascular renal disease (p= 0.022), pulse pressure (p= 0.001), and a history of CV events (p= 0.025), but not history of hypertension or diabetes mellitus alone. The median cfPWVs in diabetic nephropathy and vascular renal disease were comparable and significantly higher than median cfPWVs in other etiologies of ESRD.Conclusion. The study suggests that the etiology of ESRD is independently associated with arterial stiffness among hemodialysis patients. Furthermore, arterial stiffness was higher among patients who developed renal sequelae of either diabetes mellitus or hypertension as compared with those who have a history of either diabetes mellitus or hypertension alone.
authors.affiliation: North Hospital Center, Zgharta, Northern Lebanon, Lebanon.
authors.forename: Balsam
authors.initials: B
authors.lastname: El Ghoul
authors.affiliation: Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: Yazan
authors.identifier: 0000-0002-6364-3770
authors.initials: Y
authors.lastname: Daaboul
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
authors.forename: Serge
authors.initials: S
authors.lastname: Korjian
authors.affiliation: Lebanese American University School of Medicine, Byblos, Lebanon.
authors.forename: Andrew
authors.initials: A
authors.lastname: El Alam
authors.affiliation: Lebanese American University School of Medicine, Byblos, Lebanon.
authors.forename: Anthony
authors.identifier: 0000-0002-6986-6203
authors.initials: A
authors.lastname: Mansour
authors.affiliation: Lebanese American University School of Medicine, Byblos, Lebanon.
authors.forename: Essa
authors.identifier: 0000-0002-5056-2517
authors.initials: E
authors.lastname: Hariri
authors.affiliation: North Hospital Center, Zgharta, Northern Lebanon, Lebanon.
authors.forename: Salam
authors.initials: S
authors.lastname: Samad
authors.affiliation: Lebanese University, School of Public Health, Beirut, Lebanon.
authors.forename: Pascale
authors.identifier: 0000-0002-4780-0772
authors.initials: P
authors.lastname: Salameh
authors.affiliation: North Hospital Center, Zgharta, Northern Lebanon, Lebanon.
authors.forename: Georges
authors.initials: G
authors.lastname: Dahdah
authors.affiliation: Diagnosis Center, Hotel-Dieu Hospital, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Blacher
authors.affiliation: Diagnosis Center, Hotel-Dieu Hospital, Paris, France.
authors.forename: Michel E
authors.initials: ME
authors.lastname: Safar
authors.affiliation: Lebanese American University School of Medicine, Byblos, Lebanon; University Medical Center-Rizk Hospital, Beirut, Lebanon.
authors.forename: Sola
authors.identifier: 0000-0002-7159-7559
authors.initials: S
authors.lastname: Aoun Bahous
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000150:complications*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003928:Diabetic Nephropathies / Q000150:complications*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007676:Kidney Failure, Chronic / Q000209:etiology*; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D006435:Renal Dialysis; D012307:Risk Factors; D014652:Vascular Diseases / Q000150:complications*; D059289:Vascular Stiffness