title: Bioengineered 3D Models for Studying Human Cell-Tuberculosis Interactions.
abstract: In vivo animal models have intrinsic limitations for studying relationships between tuberculosis and its host and there is a need for alternative, in vitro cellular models. A microsphere-based 3D in vitro culture system of Mycobacterium tuberculosis-infected human blood mononuclear cells was reported to address specific aspects of host-pathogen interactions.
authors.affiliation: CNRS, UMR 7355, Orleans, France; University of Orleans, INEM, Experimental and Molecular Immunology and Neurogenetics, Orleans, France.
authors.forename: Sulayman
authors.initials: S
authors.lastname: Benmerzoug
authors.affiliation: CNRS, UMR 7355, Orleans, France; University of Orleans, INEM, Experimental and Molecular Immunology and Neurogenetics, Orleans, France. Electronic address: quesniaux@cnrs-orleans.fr.
authors.forename: Valerie F J
authors.initials: VFJ
authors.lastname: Quesniaux
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology*; D018929:Cell Culture Techniques / Q000379:methods; D002478:Cells, Cultured; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008863:Microspheres; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000472:pathogenicity; D014375:Tuberculoma / Q000382:microbiology / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Tuberculosis; bioelectrospray; extracellular matrix; granuloma; in vitro 3D cell model; microsphere