title: Dosimetric benefits of intensity-modulated radiotherapy and volumetric-modulated arc therapy in the treatment of postoperative cervical cancer patients.
abstract: As the advantage of using complex volumetric-modulated arc therapy (VMAT) in the treatment of gynecologic cancer has not yet been fully determined, the purpose of this study was to investigate the dosimetric advantages of VMAT by comparing directly with whole pelvic conformal radiotherapy (CRT) and intensity-modulated radiotherapy (IMRT) in the treatment of 15 postoperative cervical cancer patients. Four-field CRT, seven-field IMRT, and two-arc VMAT plans were generated for each patient with identical objective functions to achieve clinically acceptable dose distribution. Target coverage and OAR sparing differences were investigated through dose-volume histogram (DVH) analysis. Nondosimtric differences between IMRT and VMAT were also compared. Target coverage presented by V95% were 88.9% ± 3.8%, 99.9% ± 0.07%, and 99.9% ± 0.1% for CRT, IMRT, and VMAT, respectively. Significant differences on conformal index (CI) and conformal number (CN) were observed with CIs of 0.37 ± 0.07, 0.55 ± 0.04, 0.61 ± 0.04, and CNs of 0.33 ± 0.06, 0.55 ± 0.04, 0.60 ± 0.04 for CRT, IMRT, and VMAT, respectively. IMRT and VMAT decreased the dose to bladder and rectum significantly compared with CRT. No significant differences on the Dmean, V45, and V30 of small bowel were observed among CRT, IMRT, and VMAT. However, VMAT (10.4 ± 4.8 vs. 19.8 ± 11.0, P = 0.004) and IMRT (12.3 ± 5.0 vs. 19.8 ± 11.0, P = 0.02) decreased V40, increased the Dmax of small bowel and the irradiation dose to femoral heads compared with CRT. VMAT irradiated less dose to bladder, rectum, small bowel and larger volume of health tissue with a lower dose (V5 and V10) compared with IMRT, although the differences were not statistical significant. In conclusion, VMAT and IMRT showed significant dosimetric advantages both on target coverage and OAR sparing compared with CRT in the treatment of postoperative cervical cancer. However, no significant difference between IMRT and VMAT was observed except for slightly better dose conformity, slightly less MU, and significant shorter delivery time achieved for VMAT.
authors.affiliation: Radiotherapy and Chemotherapy Department, the 1st Affiliated Hospital of Wenhzou Medical University, Wenzhou, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Deng
authors.affiliation: Radiotherapy and Chemotherapy Department, the 1st Affiliated Hospital of Wenhzou Medical University, Wenzhou, China.
authors.forename: Ce
authors.initials: C
authors.lastname: Han
authors.affiliation: Department of Clinical Solutions Support, Elekta Instrument (Shanghai) Ltd., Shanghai, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Chen
authors.affiliation: Radiotherapy and Chemotherapy Department, the 1st Affiliated Hospital of Wenhzou Medical University, Wenzhou, China.
authors.forename: Congying
authors.initials: C
authors.lastname: Xie
authors.affiliation: Radiotherapy and Chemotherapy Department, the 1st Affiliated Hospital of Wenhzou Medical University, Wenzhou, China.
authors.forename: Jinling
authors.initials: J
authors.lastname: Yi
authors.affiliation: Radiotherapy and Chemotherapy Department, the 1st Affiliated Hospital of Wenhzou Medical University, Wenzhou, China.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Radiotherapy and Chemotherapy Department, the 1st Affiliated Hospital of Wenhzou Medical University, Wenzhou, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Radiotherapy and Chemotherapy Department, the 1st Affiliated Hospital of Wenhzou Medical University, Wenzhou, China.
authors.forename: Zhenxiang
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Radiotherapy and Chemotherapy Department, the 1st Affiliated Hospital of Wenhzou Medical University, Wenzhou, China.
authors.forename: Xiance
authors.initials: X
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D058958:Organs at Risk / Q000528:radiation effects; D010386:Pelvic Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D011184:Postoperative Period; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy* / Q000601:surgery
keywords: cervical cancer; intensity‐modulated radiotherapy; volumetric‐modulated arc therapy; whole pelvic conformal radiotherapy