title: Premature Ovarian Failure in French Canadian Leigh Syndrome.
abstract: In all surviving girls with Leigh syndrome, French Canadian variety, a mitochondrial disease, we detected premature ovarian failure, manifested as absent or arrested breast development, lack of menarche, high follicle-stimulating hormone, a prepubertal uterus, and small ovaries. Pubertal onset and progression should be evaluated in girls with mitochondrial diseases.
authors.affiliation: Division of Endocrinology and Research Center, CHU Sainte-Justine, Montréal, Québec, Canada; Centre de Santé et de Services Sociaux de Chicoutimi, Chicoutimi, Québec, Canada.
authors.forename: Chiraz
authors.initials: C
authors.lastname: Ghaddhab
authors.affiliation: Division of Medical Genetics and Research Center, CHU Sainte-Justine, Montréal, Québec, Canada.
authors.forename: Charles
authors.initials: C
authors.lastname: Morin
authors.affiliation: Centre de Santé et de Services Sociaux de Chicoutimi, Chicoutimi, Québec, Canada; Department of Pediatrics, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Catherine
authors.initials: C
authors.lastname: Brunel-Guitton
authors.affiliation: Centre de Santé et de Services Sociaux de Chicoutimi, Chicoutimi, Québec, Canada; Department of Pediatrics, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Grant A
authors.initials: GA
authors.lastname: Mitchell
authors.affiliation: Division of Endocrinology and Research Center, CHU Sainte-Justine, Montréal, Québec, Canada; Centre de Santé et de Services Sociaux de Chicoutimi, Chicoutimi, Québec, Canada.
authors.forename: Guy
authors.initials: G
authors.lastname: Van Vliet
authors.affiliation: Division of Endocrinology and Research Center, CHU Sainte-Justine, Montréal, Québec, Canada; Centre de Santé et de Services Sociaux de Chicoutimi, Chicoutimi, Québec, Canada. Electronic address: celine.huot.hsj@ssss.gouv.qc.ca.
authors.forename: Céline
authors.initials: C
authors.lastname: Huot
mesh_terms: D000293:Adolescent; D002170:Canada; D005260:Female; D006801:Humans; D007888:Leigh Disease / Q000145:classification / Q000150:complications*; D016649:Primary Ovarian Insufficiency / Q000209:etiology*
keywords: metabolic acidosis; premature ovarian failure