title: Preoperative Antihypertensive Medication in Relation to Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: A Meta-Analysis.
abstract: Background. We undertake a systematic review and meta-analysis to evaluate the effect of preoperative hypertension and preoperative antihypertensive medication to postoperative atrial fibrillation (POAF) in patients undergoing cardiac surgery.Methods. We searched PubMed, Embase, and Cochrane Library (from inception to March 2016) for eligible studies. The outcomes were the effects of preoperative hypertension, preoperative calcium antagonists regimen, preoperative ACE inhibitors regimen, and preoperative beta blocking agents regimen with POAF. We calculated pooled risk ratios (OR) and 95% CIs using random- or fixed-effects models.Results. Twenty-five trials involving 130087 patients were listed. Meta-analysis showed that the number of preoperative hypertension patients in POAF group was significantly higher (P< 0.05), while we found that there are no significant differences between two groups in Asia patients by subgroup analysis, which is in contrast to other outcomes. Compared with the Non-POAF group, the number of patients who used calcium antagonists and ACE inhibitors preoperatively in POAF group was significantly higher (P< 0.05). And we found that there were no significant differences between two groups of preoperative beta blocking agents used (P= 0.08).Conclusions. Preoperative hypertension and preoperative antihypertensive medication in patients undergoing cardiac operations seem to be associated with higher risk of POAF.
authors.affiliation: Department of Anesthesiology of the First People's Hospital of Changde City, Changde, Hunan, China.
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Zhou
authors.affiliation: Department of Anesthesiology of the First People's Hospital of Changde City, Changde, Hunan, China.
authors.forename: Xian-Xue
authors.identifier: 0000-0001-7793-7991
authors.initials: XX
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology of the First People's Hospital of Changde City, Changde, Hunan, China.
authors.forename: Dao-Bo
authors.identifier: 0000-0003-1969-7349
authors.initials: DB
authors.lastname: Pan
authors.affiliation: Department of Anesthesiology of the First People's Hospital of Changde City, Changde, Hunan, China.
authors.forename: An-Ji
authors.initials: AJ
authors.lastname: Chen
authors.affiliation: Department of Anesthesiology of the First People's Hospital of Changde City, Changde, Hunan, China.
authors.forename: Xiong-Fei
authors.initials: XF
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology of the First People's Hospital of Changde City, Changde, Hunan, China.
authors.forename: Hui-Wei
authors.initials: HW
authors.lastname: Deng
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000145:classification / Q000503:physiopathology / Q000628:therapy; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D008297:Male; D011300:Preoperative Care
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers