title: The Effect of PCDH15 Gene Variations on the Risk of Noise-induced Hearing Loss in a Chinese Population.
abstract: Noise-induced hearing loss (NIHL) is a complex disease caused by interactions between environmental and genetic factors. This study investigated whether genetic variability in protocadherin related 15 (PCDH15) underlies an increased susceptibility to the development of NIHL in a Chinese population. The results showed that compared with the TT genotype of rs11004085, CT/CC genotypes were associated with an increased risk of NIHL [adjusted odds ratio (OR) = 2.64; 95% confidence interval (CI): 1.14-6.11, P = 0.024]. Additionally, significant interactions between the rs11004085 and rs978842 genetic variations and noise exposure were observed in the high-level exposure groups (P < 0.05). Furthermore, the risk haplotype TAGCC was observed when combined with higher levels of noise exposure (P < 0.05). Thus, our study confirms that genetic variations in PCDH15 modify the susceptibility to NIHL development in humans.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Xiang Rong
authors.initials: XR
authors.lastname: Xu
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Jing Jing
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China; National Center of Occupational Safety and Health, Beijing 102308, China.
authors.forename: Qiu Yue
authors.initials: QY
authors.lastname: Yang
authors.affiliation: Henan Provincial Institute for Occupational Health, Zhengzhou 450052, Henan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Jiao
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Li Hua
authors.initials: LH
authors.lastname: He
authors.affiliation: Henan Provincial Institute for Occupational Health, Zhengzhou 450052, Henan, China.
authors.forename: Shan Fa
authors.initials: SF
authors.lastname: Yu
authors.affiliation: Henan Provincial Institute for Occupational Health, Zhengzhou 450052, Henan, China.
authors.forename: Gui Zhen
authors.initials: GZ
authors.lastname: Gu
authors.affiliation: Wugang Institute for Occupational Health, Wugang 462500, Henan, China.
authors.forename: Guo Shun
authors.initials: GS
authors.lastname: Chen
authors.affiliation: Henan Provincial Institute for Occupational Health, Zhengzhou 450052, Henan, China.
authors.forename: Wen Hui
authors.initials: WH
authors.lastname: Zhou
authors.affiliation: Henan Provincial Institute for Occupational Health, Zhengzhou 450052, Henan, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.affiliation: Henan Provincial Institute for Occupational Health, Zhengzhou 450052, Henan, China.
authors.forename: Yan Hong
authors.initials: YH
authors.lastname: Li
authors.affiliation: Wugang Institute for Occupational Health, Wugang 462500, Henan, China.
authors.forename: Huan Ling
authors.initials: HL
authors.lastname: Zhang
authors.affiliation: Henan Provincial Institute for Occupational Health, Zhengzhou 450052, Henan, China.
authors.forename: Zeng Rui
authors.initials: ZR
authors.lastname: Zhang
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Xian Ning
authors.initials: XN
authors.lastname: Jin
mesh_terms: D000070585:Cadherin Related Proteins; D015820:Cadherins / Q000235:genetics*; D002681:China; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006317:Hearing Loss, Noise-Induced / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D012307:Risk Factors
chemical_list: C498835:CDHR15, human; D000070585:Cadherin Related Proteins; D015820:Cadherins