title: Weight reduction via life-style modifications results in reverse remodelling and cardiac functional improvement in a patient with obesity.
abstract: The prevalence of obesity has increased strikingly in recent years. Obesity is associated with increased left ventricular end-diastolic dimension (LVEDD), ventricular wall thickness, left ventricular (LV) mass, left atrial diameter, subtle myocardial systolic as well as diastolic dysfunction and has been identified as an independent predictor of these changes. It's convinced that weight reduction results in cardiac reverse remodelling, while the functional changes after weight reduction are variable. Here, we present a recent case of man with moderate obesity who acquires favourable regression in chamber size, wall thickness and significant improvement in cardiac function. Briefly, after life-style modifications and comprehensive secondary prevention, great amounts of weight loss was achieved simultaneously with decreased LVEDD and increased LV ejection fraction. As dietary intervention and regular physical activity are pivotal for these benefits, this non-invasive approach for weight loss should be advocated in selected patients.
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Hou
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing, China.
authors.forename: Xin-Gang
authors.initials: XG
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing, China.
authors.forename: Qiu-Ping
authors.initials: QP
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing, China. Electronic address: cm6141@sina.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D004032:Diet; D015444:Exercise / Q000502:physiology; D015438:Health Behavior; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008019:Life Style; D008297:Male; D009765:Obesity / Q000503:physiopathology* / Q000628:therapy*; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*
keywords: Cardiac functional improvement; Cardiac remodelling; Life-style intervention; Obesity; Weight reduction