title: Enantioselective Direct α-Arylation of Pyrazol-5-ones with 2-Indolylmethanols via Organo-Metal Cooperative Catalysis.
abstract: The first catalytic asymmetric α-arylation of pyrazol-5-ones has been established by using 2-indolylmethanols as direct electrophilic arylation reagents under the cooperative catalysis of Pd(0) and a chiral phosphoric acid, which afforded the α-arylation products of pyrazol-5-ones in generally high yields and good enantioselectivities (up to 99% yield, >99% ee).
authors.affiliation: School of Chemistry and Material Science, Jiangsu Normal University , Xuzhou 221116, China.
authors.forename: Zi-Qi
authors.initials: ZQ
authors.lastname: Zhu
authors.affiliation: School of Chemistry and Material Science, Jiangsu Normal University , Xuzhou 221116, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.affiliation: School of Chemistry and Material Science, Jiangsu Normal University , Xuzhou 221116, China.
authors.forename: Jin-Xi
authors.initials: JX
authors.lastname: Liu
authors.affiliation: School of Chemistry and Material Science, Jiangsu Normal University , Xuzhou 221116, China.
authors.forename: Ji-Yu
authors.initials: JY
authors.lastname: Tao
authors.affiliation: School of Chemistry and Material Science, Jiangsu Normal University , Xuzhou 221116, China.
authors.forename: Feng
authors.identifier: 0000-0003-3922-0708
authors.initials: F
authors.lastname: Shi