title: Clear cell adenocarcinoma of cervix in 1-year-old girl without in utero exposure to diethylstilbestrol: an uncommon tumour at an uncommon age and site.
abstract: Adenocarcinoma of cervix constitutes about 10-15% cases of carcinoma cervix. Clear cell variant is even a rarer variant of adenocarcinoma. It rarely occurs in the paediatric age group and a known risk factor is in utero exposure to diethylstilbestrol (DES). We report here a case of primary cervical tumour in a 1-year-old girl, which was initially suspected to be an embryonal rhabdomyosarcoma botryoides. Histopathology with immunohistochemical analysis revealed clear cell adenocarcinoma. There was no maternal history of DES intake during pregnancy. We discuss the histopathological characteristics and clinical course of this unusual tumour.
authors.affiliation: Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Aditi
authors.initials: A
authors.lastname: Arora
authors.affiliation: Fatima Hospital, Lucknow, Uttar Pradesh, India.
authors.forename: Anurag
authors.initials: A
authors.lastname: Rastogi
authors.affiliation: Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Azfar
authors.initials: A
authors.lastname: Neyaz
authors.affiliation: Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Nuzhat
authors.initials: N
authors.lastname: Husain
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology / Q000601:surgery*; D003937:Diagnosis, Differential; D004054:Diethylstilbestrol; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007223:Infant; D011247:Pregnancy; D018233:Rhabdomyosarcoma, Embryonal / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D004054:Diethylstilbestrol