title: Prostate volume index stratified prostate cancer risk in patients elected to a first random biopsy set.
abstract: OBJECTIVE
  To investigate prostate volume index (PVI), defined as the ratio of volume of the transitional zone on that of the peripheral zone, as a factor stratifying prostate cancer (PCA) risk in patients elected to a first random biopsy set.
  
  
  METHODS
  The study evaluated 596 patients who were elected to a first random biopsy set because of suspected PCA in a period between September 2010 and September 2015. Prostate volume index was dichotomized to PVI ≤1 vs PVI >1. The multivariate logistic regression model investigated clinical factors with dichotomized PVI associating with PCA.
  
  
  RESULTS
  The detection rate of PCA was 49%. The dichotomized PVI >1 stratified PCA risk (odds ratio [OR] 0.455; p<0.0001) beyond age (OR 1.062; p<0.0001), PSA (OR 1.167; p<0.0001), PV (OR 0.957; p<0.0001), and abnormal digital rectal examination (OR 2.094; p<0.0001). The goodness of fit statistics assessed model efficacy.
  
  
  CONCLUSIONS
  A large cohort of patients elected to a first random biopsy set had PCA risk stratified by dichotomized PVI beyond other clinical independent factors. Confirmatory studies are required.
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Antonio B
authors.initials: AB
authors.lastname: Porcaro
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Corsi
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Nicolò
authors.initials: N
authors.lastname: de Luyk
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Sebben
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Tafuri
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Bizzotto
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cacciamani
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: De Marchi
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Tania
authors.initials: T
authors.lastname: Processali
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Mattevi
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Novella
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Cerruto
authors.affiliation:  Department of Pathology, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Brunelli
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Siracusano
authors.affiliation:  Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
authors.forename: Walter
authors.initials: W
authors.lastname: Artibani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D051517:Digital Rectal Examination; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D017430:Prostate-Specific Antigen