title: Effect of Delayed Cord Clamping on Hematocrit, and Thermal and Hemodynamic Stability in Preterm Neonates: A Randomized Controlled Trial.
abstract: OBJECTIVE
  To evaluate the short term clinical effects of delayed cord clamping in preterm neonates.
  
  
  METHODS
  Randomized controlled trial.
  
  
  METHODS
  A tertiary care neonatal unit from October 2013 to September 2014.
  
  
  METHODS
  78 mothers with preterm labor between 27 to 316/7 weeks gestation.
  
  
  METHODS
  Early cord clamping (10 s), delayed cord clamping (60 s) or delayed cord clamping (60 s) along with intramuscular ergometrine (500 µg) administered to the mother.
  
  
  METHODS
  Primary: hematocrit at 4 h after birth; Secondary: temperature on admission in neonatal intensive care unit, blood pressure (non-invasive) at 12 h, and urinary output for initial 72 h.
  
  
  RESULTS
  Mean (SD) hematocrit at 4 h of birth was 58.9 (2.4)% in delayed cord clamping group, and 58.7 (2.1) % in delayed cord clamping with ergometrine group as compared to 47.6 (1.3) % in early cord clamping group. Mean (SD) temperature on admission in NICU was 35.8 (0.2)ºC, 35.8 (0.3)ºC, and 35.5 (0.3)ºC, respectively in these three groups. The mean (SD) non-invasive blood pressure at 12 h of birth was 45.8 (7.0) mmHg, 45.8 (9.0) mmHg, and 35.5 (8.6) mmHg, respectively in these three groups. Mean (SD) urinary output on day 1 of life was 1.1 (0.2) mL/kg/h, 1.1 (0.2) mL/kg/hr and 0.9 (0.2) ml/kg/h, respectively.
  
  
  CONCLUSIONS
  In preterm neonates delayed cord clamping along with lowering the infant below perineum or incision site and administration of ergometrine to mother has significant benefits in terms of increase in hematocrit, higher temperature on admission, and higher blood pressure and urinary output during perinatal transition.
authors.affiliation: Department of Neonatology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India. Correspondence to: Dr Niraj Kumar Dipak, Department of Neonatology, Seth GS Medical College and KEM Hospital, Acharya Donde Marg, Parel, Mumbai 400 012, Maharashtra, India. drndipak@gmail.com.
authors.forename: Niraj Kumar
authors.initials: NK
authors.lastname: Dipak
authors.forename: Ruchi Nimish
authors.initials: RN
authors.lastname: Nanavat
authors.forename: Nand Kishore
authors.initials: NK
authors.lastname: Kabra
authors.forename: Anita
authors.initials: A
authors.lastname: Srinivasan
authors.forename: Anitha
authors.initials: A
authors.lastname: Ananthan
mesh_terms: D000740:Anemia; D001794:Blood Pressure; D003250:Constriction; D005260:Female; D006400:Hematocrit; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D013513:Obstetric Surgical Procedures / Q000706:statistics & numerical data*; D011247:Pregnancy; D014470:Umbilical Cord / Q000098:blood supply / Q000502:physiology / Q000601:surgery