title: Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women.
abstract: Environmental exposure to polycyclic aromatic hydrocarbons (PAHs) is prevalent and may adversely impact pregnancy and development of the fetus. The purpose of this exploratory study was to examine urinary PAH metabolites in potential association with mediators of these outcomes. To do so, we measured a panel of 12 inflammatory, angiogenic, and oxidative stress biomarkers in plasma or urine from women in their third trimester of pregnancy (n = 200). Urinary PAH metabolites were highly detectable (>88%) in the study population, and most were higher in women who had lower education levels, higher body mass index, and who were African-American. Some PAH metabolites showed consistent positive associations with the plasma inflammation marker C-reactive protein (CRP) and the urinary oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane. For example, an interquartile range increase in 2-hydroxynapthalene was associated with a 35% increase in CRP (95% confidence interval = -0.13, 83.2), a 14% increase in 8-OHdG (95% confidence interval =0.59, 30.1), and a 48% increase in 8-isoprostane (95% confidence interval =16.7, 87.0). These data suggest that exposure to PAHs may cause systemic changes during pregnancy that could lead to adverse pregnancy or developmental outcomes; however, these results should be corroborated in a larger study population.
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences , Research Triangle Park, North Carolina 27709, United States.|Department of Environmental Health Sciences, University of Michigan School of Public Health , Ann Arbor, Michigan 48109, United States.
authors.forename: Kelly K
authors.initials: KK
authors.lastname: Ferguson
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts 02115, United States.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: McElrath
authors.affiliation: NSF International , Ann Arbor, Michigan 48105, United States.
authors.forename: Gerry G
authors.initials: GG
authors.lastname: Pace
authors.affiliation: NSF International , Ann Arbor, Michigan 48105, United States.
authors.forename: David
authors.initials: D
authors.lastname: Weller
authors.affiliation: Division of Nephrology, Department of Medicine, University of Michigan , Ann Arbor, Michigan 48109, United States.
authors.forename: Lixia
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Division of Nephrology, Department of Medicine, University of Michigan , Ann Arbor, Michigan 48109, United States.
authors.forename: Subramaniam
authors.initials: S
authors.lastname: Pennathur
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts 02115, United States.
authors.forename: David E
authors.initials: DE
authors.lastname: Cantonwine
authors.affiliation: Department of Environmental Health Sciences, University of Michigan School of Public Health , Ann Arbor, Michigan 48109, United States.
authors.forename: John D
authors.initials: JD
authors.lastname: Meeker
mesh_terms: D015415:Biomarkers / Q000737:chemistry / Q000652:urine; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007249:Inflammation; D018919:Neovascularization, Physiologic; D018384:Oxidative Stress; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry / Q000652:urine*; D011247:Pregnancy
chemical_list: D015415:Biomarkers; D011084:Polycyclic Aromatic Hydrocarbons