title: TWO CASES OF ACUTE RETINAL NECROSIS DUE TO VARICELLA ZOSTER DESPITE PRIOR SHINGLES VACCINATION.
abstract: OBJECTIVE
  To review two cases of acute retinal necrosis in adults due to varicella zoster virus despite prior shingles vaccination.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  A 62-year-old man and a 64-year-old man with unilateral acute retinal necrosis who had shingles vaccinations 16 and 7 months before their ocular symptoms.
  
  
  RESULTS
  Polymerase chain reaction confirmation of varicella zoster virus in the anterior chambers of both patients. Both patients had good responses to oral antiviral therapy and topical and/or oral steroids.
  
  
  CONCLUSIONS
  These two cases demonstrate that singles vaccination is not an absolute protection against varicella zoster virus-related acute retinal necrosis. However, such vaccination may reduce the severity of the acute retinal necrosis.
authors.affiliation: Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Weinlander
authors.forename: Angeline L
authors.initials: AL
authors.lastname: Wang
authors.forename: Pimkwan
authors.initials: P
authors.lastname: Jaru-Ampornpan
authors.forename: Michael M
authors.initials: MM
authors.lastname: Altaweel
authors.forename: T Michael
authors.initials: TM
authors.lastname: Nork
mesh_terms: D015828:Eye Infections, Viral / Q000209:etiology*; D053061:Herpes Zoster Vaccine / Q000009:adverse effects*; D014645:Herpesvirus 3, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D015882:Retinal Necrosis Syndrome, Acute / Q000821:virology*; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D053061:Herpes Zoster Vaccine