title: The value of microparticles in detecting acute rejection episodes after liver transplantation.
abstract: BACKGROUND
  Non-invasive markers for diagnosis of acute rejection (AR) following liver transplantation have not been developed, yet.
  
  
  OBJECTIVE
  We analyzed the correlation of plasma microparticle levels (MP) with AR.
  
  
  METHODS
  MP (CD4, CD8, CD25, CD31, MHC) of 11 AR patients and 11 controls were analyzed within the first week after transplantation.
  
  
  RESULTS
  CD4, CD8 and CD31 positive MP were higher in the AR, whereas overall MP count, CD25 and MHCI positive MP proportions did not differ between both groups.
  
  
  CONCLUSIONS
  MP dynamics within the first period of transplantation could help to clarify on-going mechanisms of immunomodulation.
authors.affiliation: a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Mehmet Haluk
authors.initials: MH
authors.lastname: Morgul
authors.affiliation: a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Splith
authors.affiliation: b Department of Medicine I Cardiology, Angiology and Intensive Care , General Hospital Chemnitz gGmbH , Chemnitz , Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Leonhardt
authors.affiliation: a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Nathanael
authors.initials: N
authors.lastname: Raschzok
authors.affiliation: a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Reutzel-Selke
authors.affiliation: a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Rosa Bianca
authors.initials: RB
authors.lastname: Schmuck
authors.affiliation: a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Andreou
authors.affiliation: a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Georgi
authors.initials: G
authors.lastname: Atanasov
authors.affiliation: a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Benzing
authors.affiliation: a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Krenzien
authors.affiliation: c Department of Visceral , Transplant, Thoracic, and Vascular Surgery, University Hospital Leipzig , Leipzig , Germany.
authors.forename: Hans-Michael
authors.initials: HM
authors.lastname: Hau
authors.affiliation: d Department of General , Visceral, and Vascular Surgery, University Hospital Jena , Jena , Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Felgendreff
authors.affiliation: e Department of Traumatology, Hand and Orthopedic Surgery , Harzklinikum Dorothea Christiane Erxleben GmbH , Quedlinburg , Germany.
authors.forename: Sergej
authors.initials: S
authors.lastname: Klunk
authors.affiliation: a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Johann
authors.initials: J
authors.lastname: Pratschke
authors.affiliation: a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Igor Maximillian
authors.initials: IM
authors.lastname: Sauer
authors.affiliation: a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Schmelzle
mesh_terms: D015704:CD4 Antigens / Q000097:blood; D016827:CD8 Antigens / Q000097:blood; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D005260:Female; D006084:Graft Rejection / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000097:blood; D013997:Time Factors
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens; D019408:Platelet Endothelial Cell Adhesion Molecule-1
keywords: T cell-derived microparticles; endothelial cell-derived microparticles; graft monitoring; non-invasive marker; regulatory T cells