title: The modulatory effect of (-)-epigallocatechin 3-O-(3-O-methyl) gallate (EGCG3″Me) on intestinal microbiota of high fat diet-induced obesity mice model.
abstract: (-)-Epigallocatechin 3-O-(3-O-methyl) gallate (EGCG3″Me) has exhibited multiple beneficial effects on the prevention of obesity in oolong tea. However, its absorption is relatively low, and the potential to be fully utilized is not completely elucidated. Therefore, with human flora-associated (HFA) mice model, the effect of EGCG3″Me on high fat diet-induced obesity was investigated by high-throughput sequencing. The shifts in relative abundance of the dominant taxa at the phylum, family and genus levels showed the dramatically effects of EGCG3″Me. Despite significant inter-individual variation, a large increase in Bacteroidetes with concomitant decrease of Firmicutes was observed after the administration of EGCG3″Me for 8weeks, with a corresponding decrease in the Firmicutes/Bacteroidetes ratio, which reflect the modulatory effect of EGCG3″Me on intestinal microbiota. The results showed that EGCG3″Me may have prebiotic-like activity and can be used as a functional food component with potential therapeutic utility in manipulating intestinal microbiota, contributing to the prevention of gut dysbiosis.
authors.affiliation: Department of Food Science and Engineering, School of Marine Sciences, Ningbo University, Ningbo 315211, PR China.
authors.forename: Mei
authors.initials: M
authors.lastname: Cheng
authors.affiliation: Department of Food Science and Engineering, School of Marine Sciences, Ningbo University, Ningbo 315211, PR China; Key Laboratory of Animal Protein Deep Processing Technology of Zhejiang Province, Ningbo University, Ningbo 315211, PR China. Electronic address: zhangxin@nbu.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Food Science and Engineering, School of Marine Sciences, Ningbo University, Ningbo 315211, PR China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Miao
authors.affiliation: Department of Food Science and Engineering, School of Marine Sciences, Ningbo University, Ningbo 315211, PR China.
authors.forename: Jinxuan
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Food Science and Engineering, School of Marine Sciences, Ningbo University, Ningbo 315211, PR China.
authors.forename: Zufang
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Food Science and Engineering, School of Marine Sciences, Ningbo University, Ningbo 315211, PR China.
authors.forename: Peifang
authors.initials: P
authors.lastname: Weng
mesh_terms: D000328:Adult; D000818:Animals; D041963:Bacteroidetes / Q000302:isolation & purification; D004269:DNA, Bacterial / Q000302:isolation & purification; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D005243:Feces / Q000382:microbiology; D005260:Female; D000068536:Bacillota / Q000302:isolation & purification; D055951:Functional Food; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000139:chemically induced / Q000382:microbiology*; D010936:Plant Extracts / Q000494:pharmacology; D056692:Prebiotics; D013662:Tea / Q000737:chemistry
chemical_list: D004269:DNA, Bacterial; D010936:Plant Extracts; D056692:Prebiotics; D013662:Tea; D005707:Gallic Acid; C573278:epigallocatechin-3-O-(3''-O-methyl)-gallate
keywords: EGCG3″Me; Intestinal microbiota; Modulatory effect; Obesity; Prebiotic