title: A quantitive evaluation of gap junctions and their morphological alteration during differentiation of amphibian notochord cells.
abstract: The early development of notochord cells may be divided into three phases according to the quantitative evaluation of gap junctions: late gastrula, neurula and from tailbud to tadpole. In late gastrula, the percentage of the area of gap junctions to total membrane is 0.054% and most of the gap junctions are small in size. During the stages of neurulation, the ratios of gap junctions to total membrane area increase and remain high (0.106-0.181 %), and the majority of the gap junctions are of medium and large size. The high ratios of gap junctions to membrane area during neurulation suggests that intercellular communication via gap junctions is important during this period. In the stages from tailbud to tadpole the ratios decrease and drop drastically to 0.001 % and most of the gap junctions found are small in size. It is in the last phase that gap junctions of altered configuration appear.
authors.affiliation: Shanghai Institute of Cell Biology, Academia Sinica, 200031, Shanghai, China.
authors.forename: Zeng
authors.initials: Z
authors.lastname: Mi-Bai
authors.affiliation: Shanghai Institute of Cell Biology, Academia Sinica, 200031, Shanghai, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Mei-Yun
keywords: Amphibia; Differentiation; Gap junction; Notochord