title: The Application of Proteomics to Traumatic Brain and Spinal Cord Injuries.
abstract: Traumatic brain injury (TBI) and traumatic spinal cord injury (SCI), collectively termed neurotrauma, are two parallel neurological conditions that can cause long-lasting neurological impairment and other comorbidities in patients, while at the same time, can create a high burden to society. To date, there are still no FDA-approved therapeutic interventions for either TBI or SCI. Recent advances in proteomic technologies, including tandem mass spectrometry, as well as imaging mass spectrometry, have enabled new approaches to study the differential proteome in TBI and SCI with the use of either animal disease models and/or biosamples from clinical observational studies. Thus, the applications of state-of-the-art proteomic method hold promises in shedding light on identifying clinically useful neurotrauma "biomarkers" and/or in identifying distinct and, otherwise, unobvious systems pathways or "key drivers" that can be further exploited as new therapeutic intervention targets.
authors.affiliation: Program for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA.|Department of Chemistry, University of Florida, Gainesville, FL, 32611, USA.|Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia, PO Box 426, Alexandria, 21321, Egypt.
authors.forename: George Anis
authors.initials: GA
authors.lastname: Sarkis
authors.affiliation: Program for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA.|Department of Chemistry, University of Florida, Gainesville, FL, 32611, USA.
authors.forename: Manasi D
authors.initials: MD
authors.lastname: Mangaonkar
authors.affiliation: Program for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA.|Biological Sciences Division/Integrative Omics, Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA, 99352, USA.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Moghieb
authors.affiliation: Department of Chemistry, University of Florida, Gainesville, FL, 32611, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Lelling
authors.affiliation: Department of Chemistry, University of Florida, Gainesville, FL, 32611, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Guertin
authors.affiliation: Program for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA.|Department of Chemistry, University of Florida, Gainesville, FL, 32611, USA.
authors.forename: Hamad
authors.initials: H
authors.lastname: Yadikar
authors.affiliation: Program for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Program for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA.
authors.forename: Firas
authors.initials: F
authors.lastname: Kobeissy
authors.affiliation: Program for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA. kawangwang17@gmail.com.|Department of Neuroscience, University of Florida, Gainesville, FL, 32611, USA. kawangwang17@gmail.com.|Department of Physiological Sciences, University of Florida, Gainesville, FL, 32611, USA. kawangwang17@gmail.com.|Department of Chemistry, University of Florida, Gainesville, FL, 32611, USA. kawangwang17@gmail.com.
authors.forename: Kevin K W
authors.initials: KK
authors.lastname: Wang
mesh_terms: D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism*; D015897:Comorbidity; D004195:Disease Models, Animal; D006801:Humans; D013058:Mass Spectrometry; D040901:Proteomics; D013119:Spinal Cord Injuries / Q000378:metabolism*
chemical_list: D015415:Biomarkers
keywords: Mass spectrometry; Mass spectrometry imaging; Spinal cord injury neuroproteomics; Systems biology; Traumatic brain injury