title: Changes in the total effective xenoestrogen burden (TEXB) of breast cancer patients during an 18-month post-surgical follow-up.
abstract: We aimed to assess changes in the total effective xenoestrogen burden (TEXB) -a biomarker of combined effect of mixtures of xenoestrogens- in breast cancer patients at surgery (breast adipose tissue) and at different time points during an 18-month follow-up (abdominal adipose tissue), and to analyze the potential influence of socio-demographic, reproductive, tumor, and treatment characteristics on TEXB levels. TEXB-alpha (due to persistent organohalogenated chemicals) and TEXB-beta (due mainly to endogenous estrogens) were quantified in 44 women. TEXB values significantly increased over follow-up (p <0.001); the largest difference was observed at 6-12 months post-surgery (p <0.001); then decreased over time. TEXB-alpha at 6-18 months was significantly higher in younger patients with estrogen receptor positivity (p=0.034) and in those receiving anti-neoplasm chemotherapy. Cancer treatment may be responsible for the increase in TEXB-alpha observed in patients with hormone-dependent tumors, which may confer to xenoestrogens a role in the progression of the disease.
authors.affiliation: University of Granada, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Complejo Hospitalario Universitario de Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: marieta@ugr.es.
authors.forename: Mariana F
authors.initials: MF
authors.lastname: Fernandez
authors.affiliation: CIBER en Epidemiología y Salud Pública (CIBERESP), Spain; Hospital del Mar Research Institute-IMIM, Barcelona, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Pumarega
authors.affiliation: CIBER en Epidemiología y Salud Pública (CIBERESP), Spain; Hospital del Mar Research Institute-IMIM, Barcelona, Spain; School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Miquel
authors.initials: M
authors.lastname: Porta
authors.affiliation: University of Granada, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Complejo Hospitalario Universitario de Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Molina-Molina
authors.affiliation: University of Granada, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Complejo Hospitalario Universitario de Granada, Spain.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Arrebola
authors.affiliation: University of Granada, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Complejo Hospitalario Universitario de Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Olea
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001822:Body Burden; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D004785:Environmental Pollutants / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000378:metabolism*; D008875:Middle Aged; D011184:Postoperative Period
chemical_list: D004785:Environmental Pollutants; D004967:Estrogens; D006843:Hydrocarbons, Chlorinated
keywords: TEXB; breast cancer; cancer treatment; chemotherapy; estrogen receptor tumors; follow up; total effective xenoestrogen burden