title: A catalytic enantioselective approach to tetrol bearing vicinal all-carbon quaternary stereogenic centers.
abstract: The first highly enantioselective catalytic protocol for selective manipulation of tetrol benzylidene acetals through chiral phosphoric acid mediated oxidative desymmetrization is reported. This efficient approach provides a general access to vicinal all-carbon quaternary stereogenic center structural motifs, as well as structures containing vicinal tertiary and quaternary stereocenters enantioselectively. The synthetic utility has been furthermore demonstrated by transformations and gram-scale processes.
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China. wzheng@nju.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China. wzheng@nju.edu.cn.
authors.forename: Kou-Sen
authors.initials: KS
authors.lastname: Cao
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China. wzheng@nju.edu.cn.
authors.forename: Wen-Hua
authors.identifier: http://orcid.org/0000-0002-0299-3953
authors.initials: WH
authors.lastname: Zheng