title: Increase of body mass index (BMI) from 1.5 to 3 years of age augments the degree of insulin resistance corresponding to BMI at 12 years of age.
abstract: To elucidate the effect of early growth patterns on the metabolic sensitivity to adiposity, we examined the relationship between the homeostatic model assessment of insulin resistance (HOMA-IR) and body mass index (BMI) levels at 12 years of age in 101 boys and 91 girls in a birth cohort. Children with an increase in BMI from the ages of 1.5 to 3 years exhibited a greater increase of HOMA-IR per BMI increase at 12 years of age compared to those with a decrease in BMI or stable BMI from 1.5 to 3 years. This suggests that children who show an increase in BMI from 1.5 to 3 years, a period normally characterized by a decreased or stable BMI, are more prone to developing insulin resistance at 12 years of age.
authors.affiliation: Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu, Tochigi-ken, 321-0293.
authors.forename: Osamu
authors.initials: O
authors.lastname: Arisaka
authors.affiliation: Department of Public Health, Dokkyo Medical University School of Medicine, Mibu.
authors.forename: Toshimi
authors.initials: T
authors.lastname: Sairenchi
authors.affiliation: Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu.
authors.forename: Go
authors.initials: G
authors.lastname: Ichikawa
authors.affiliation: Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu.
authors.forename: Satomi
authors.initials: S
authors.lastname: Koyama
mesh_terms: D050154:Adiposity; D015992:Body Mass Index; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D011379:Prognosis
keywords: BMI; adiposity rebound; insulin resistance; metabolic sensitivity; toddler