title: The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration.
abstract: The PARK2 gene encodes an ubiquitin E3 ligase that is involved in mitochondrial homeostasis and linked to Parkinson's disease. In this issue, Gupta et al. (2017) demonstrate that PARK2 expression is frequently reduced in human cancers and that this alteration leads to dysregulated PI3K signaling.
authors.affiliation: Oncology R&D Group, Pfizer Worldwide Research & Development, 10646/CB4, Science Center Drive, San Diego, CA 92121, USA.
authors.forename: Nathan T
authors.initials: NT
authors.lastname: Ihle
authors.affiliation: Oncology R&D Group, Pfizer Worldwide Research & Development, 10646/CB4, Science Center Drive, San Diego, CA 92121, USA. Electronic address: robert.abraham@pfizer.com.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Abraham
mesh_terms: D006801:Humans; D008928:Mitochondria; D009369:Neoplasms; D010300:Parkinson Disease / Q000235:genetics; D019869:Phosphatidylinositol 3-Kinases; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; D019869:Phosphatidylinositol 3-Kinases