title: Hemoglobin Willamette (β51Pro → Arg): Case Report and Literature Review.
abstract: We report a case of hemoglobin (Hb) Willamette (β51 Pro → Arg) in the Hematology Department of a tertiary hospital in Fortaleza, Northeast of Brazil. A literature review of the cases described in health sciences databases using as a descriptor Hb Willamette was performed, revealing 12 reported cases, of which only one presented with anemia. Herein, we describe a case of a female 29 years old, with hemoglobinopathy Willamette presenting clinically with anemia, having the lowest hemoglobin rate of the published cases. The relatives of the patient were evaluated andthe patient's mother corresponded to the first description of the association between Hb Willamette and HbC. Among the hemoglobinopathies, hemoglobin Willamette is an extremely rare disease; therefore it is important to analyze its clinical and laboratory manifestations for accurate diagnosis and assessment of potential interactions with other genetic variants.
authors.affiliation: Department of Internal Medicine, Dr. César Cals General Hospital , Fortaleza.
authors.forename: Orivaldo Alves
authors.initials: OA
authors.lastname: Barbosa
authors.affiliation: School of Medicine, State University of Ceará , Fortaleza, Brazil.
authors.forename: Matheus Martins
authors.initials: MM
authors.lastname: de Sousa Dias
authors.affiliation: School of Medicine, State University of Ceará , Fortaleza, Brazil.
authors.forename: Saymon Medeiros
authors.initials: SM
authors.lastname: Távora
authors.affiliation: Hematology Department, University Hospital Walter Cantídio, State University of Ceará , Fortaleza, Brazil.
authors.forename: Gentil Claudino
authors.initials: GC
authors.lastname: de Galiza Neto
authors.affiliation: Hematology Department, University Hospital Walter Cantídio, State University of Ceará , Fortaleza, Brazil.
authors.forename: Jacqueline Holanda
authors.initials: JH
authors.lastname: de Souza
authors.affiliation: Department of Internal Medicine, Dr. César Cals General Hospital , Fortaleza.
authors.forename: Herivaldo Ferreira
authors.initials: HF
authors.lastname: da Silva
keywords: Anemia; congenital; hemoglobin Willamette; hemoglobins; hemolytic