title: PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides.
abstract: In most eukaryotes, phosphoinositides (PIs) have crucial roles in multiple cellular functions. Although the cellular levels of phosphatidylinositol 5-phosphate (PI5P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) are extremely low relative to some other PIs, emerging evidence demonstrates that both lipids are crucial for the endocytic pathway, intracellular signaling, and adaptation to stress. Mutations that causes defects in the biosynthesis of PI5P and PI(3,5)P2are linked to human diseases including neurodegenerative disorders. Here, we review recent findings on cellular roles of PI5P and PI(3,5)P2, as well as the pathophysiological importance of these lipids.Key words: Phosphoinositides, Membrane trafficking, Endocytosis, Vacuoles/Lysosomes, Fab1/PIKfyve.
authors.affiliation: Life Sciences Institute, University of Michigan.
authors.forename: Junya
authors.initials: J
authors.lastname: Hasegawa
authors.affiliation: Life Sciences Institute, University of Michigan.
authors.forename: Bethany S
authors.initials: BS
authors.lastname: Strunk
authors.affiliation: Life Sciences Institute, University of Michigan.
authors.forename: Lois S
authors.initials: LS
authors.lastname: Weisman
mesh_terms: D000818:Animals; D004194:Disease; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism; D018384:Oxidative Stress; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*
chemical_list: D018129:Phosphatidylinositol Phosphates; C106336:phosphatidylinositol 3,5-diphosphate; C113567:phosphatidylinositol 5-phosphate
keywords: Endocytosis; Fab1/PIKfyve; Membrane trafficking; Phosphoinositides; Vacuoles/Lysosomes