title: Effect of orotic acid on the mitosis of phytohaemagglutinin stimulated human lymphocytes in culture.
abstract: The addition of excess orotic acid to cultures of normal human lymphocytes stimulated with phytohaemagglutinin causes a reduction in the mitotic rate. It is suggested that this is caused by competition for the available 5-phosphoribosyl-1-pyrophosphate in the cell leading to a reduced purine synthesis. The significance of these results with regard to orotic aciduria is discussed.
authors.affiliation: University Department of Medical Genetics, The Royal Infirmary, Manchester, UK.
authors.forename: J
authors.initials: J
authors.lastname: Timson