title: Injectable and thermally contractible hydroxypropyl methyl cellulose/Fe3O4for magnetic hyperthermia ablation of tumors.
abstract: The development of efficient strategies for the magnetic hyperthermia ablation of tumors remains challenging. To overcome the significant safety limitations, we developed a thermally contractible, injectable and biodegradable material for the minimally invasive and highly efficient magnetic hyperthermia ablation of tumors. This material was composed of hydroxypropyl methyl cellulose (HPMC), polyvinyl alcohol (PVA) and Fe3O4. The thermal contractibility of HPMC/Fe3O4was designed to avoid damaging the surrounding normal tissue upon heating, which was confirmed by visual inspection, ultrasound imaging and computed tomography (CT). The efficient injectability of HPMC/Fe3O4was proven using a very small needle. The biosafety of HPMC/Fe3O4was evaluated by MTT and biochemical assays as well as flow cytometry (FCM). All the aforementioned data demonstrated the safety of HPMC/Fe3O4. The results of in vitro and ex vivo experiments showed that the temperature and necrotic volume of excised bovine liver were positively correlated with the HPMC/Fe3O4weight, iron content and heating duration. The in vivo experimental results showed that the tumors could be completely ablated using 0.06 ml of HPMC/60%Fe3O4after 180 s of induction heating. We believe that this novel, safe and biodegradable material will promote the rapid bench-to-bed translation of magnetic hyperthermia technology, and it is also expected to bring a new concept for the biomaterial research field.
authors.affiliation: Chongqing Key Laboratory of Ultrasound Molecular Imaging & State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China.
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Wang
authors.affiliation: Chongqing Key Laboratory of Ultrasound Molecular Imaging & State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Chongqing Key Laboratory of Ultrasound Molecular Imaging & State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ling
authors.affiliation: Chongqing Key Laboratory of Ultrasound Molecular Imaging & State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Liu
authors.affiliation: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Cai
authors.affiliation: Chongqing Key Laboratory of Ultrasound Molecular Imaging & State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China.
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Chongqing Key Laboratory of Ultrasound Molecular Imaging & State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China.
authors.forename: Xiuzhen
authors.initials: X
authors.lastname: Tang
authors.affiliation: Chongqing Key Laboratory of Ultrasound Molecular Imaging & State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liang
authors.affiliation: Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, PR China.
authors.forename: Yini
authors.initials: Y
authors.lastname: Chen
authors.affiliation: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.
authors.forename: Hangrong
authors.initials: H
authors.lastname: Chen
authors.affiliation: The Center of Material Analysis and Testing of Chongqing University of Science & Technology, Chongqing, 400010, PR China.
authors.forename: Dengming
authors.initials: D
authors.lastname: Chen
authors.affiliation: The Center of Material Analysis and Testing of Chongqing University of Science & Technology, Chongqing, 400010, PR China.
authors.forename: Chunhong
authors.initials: C
authors.lastname: Li
authors.affiliation: Chongqing Key Laboratory of Ultrasound Molecular Imaging & State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Hu
authors.affiliation: Chongqing Key Laboratory of Ultrasound Molecular Imaging & State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China; Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, PR China. Electronic address: zhengyuanyi@gmail.com.
authors.forename: Yuanyi
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000818:Animals; D002417:Cattle; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D006979:Hyperthermia, Induced; D065347:Hypromellose Derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D007267:Injections; D008099:Liver / Q000473:pathology; D060328:Magnetic Phenomena; D008819:Mice, Nude; D009369:Neoplasms / Q000628:therapy*; D013696:Temperature
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D065347:Hypromellose Derivatives
keywords: Hydroxypropyl methyl cellulose; Magnetic hyperthermia; Thermally contractible; Tumor therapy