title: Immunoexpression of GLUT-1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands.
abstract: This study aimed to evaluate and compare the immunoexpression of glucose transporter-1 (GLUT-1) and angiogenic index between pleomorphic adenomas (PAs), adenoid cystic carcinomas (ACCs), and mucoepidermoid carcinomas (MECs) of the salivary glands, and establish associations with the respective subtype/histological grade. Twenty PAs, 20 ACCs, and 10 MECs were submitted to morphological and immunohistochemical analysis. GLUT-1 expression was semi-quantitatively evaluated and angiogenic index was assessed by microvessel counts using anti-CD34 antibody. Higher GLUT-1 immunoexpression was observed in the MECs compared to PAs and ACCs (p = 0.022). Mean number of microvessels was 66.5 in MECs, 40.4 in PAs, and 21.2 in ACCs (p < 0.001). GLUT-1 expression and angiogenic index showed no significant correlation in the tumors studied. Results suggest that differences in biological behavior of the studied tumors are related to GLUT-1. Benign and malignant salivary gland tumors differ in the angiogenic index; however, angiogenesis may be independent of the tumor cell's metabolic demand.
authors.affiliation: Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil. leliabsouza@gmail.com.|Departamento de Odontologia, Universidade Federal do Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, CEP 59056-000, Brazil. leliabsouza@gmail.com.
authors.forename: Lélia Batista
authors.initials: LB
authors.lastname: de Souza
authors.affiliation: Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.|Department of Pathology and Forensic Medicine, Federal University of Amazonas, Manaus, AM, Brazil.
authors.forename: Lucileide Castro
authors.initials: LC
authors.lastname: de Oliveira
authors.affiliation: State University of Paraíba, Campina Grande, PB, Brazil.
authors.forename: Cassiano Francisco Weege
authors.initials: CFW
authors.lastname: Nonaka
authors.affiliation: Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Maria Luiza Diniz de Sousa
authors.initials: MLDS
authors.lastname: Lopes
authors.affiliation: Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Leão Pereira
authors.initials: LP
authors.lastname: Pinto
authors.affiliation: Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Lélia Maria Guedes
authors.initials: LMG
authors.lastname: Queiroz
mesh_terms: D008949:Adenoma, Pleomorphic / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D003528:Carcinoma, Adenoid Cystic / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D018277:Carcinoma, Mucoepidermoid / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D027342:Excitatory Amino Acid Transporter 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D055806:Microvessels / Q000473:pathology; D008875:Middle Aged; D060787:Neoplasm Grading; D009389:Neovascularization, Pathologic; D012468:Salivary Gland Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D012469:Salivary Glands / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D027342:Excitatory Amino Acid Transporter 2
keywords: Adenoid cystic carcinoma; Angiogenic index; Glucose transporter; Mucoepidermoid carcinoma; Pleomorphic adenoma