title: Covalent Modifications of RUNX Proteins: Structure Affects Function.
abstract: The RUNX family of transcription factors plays important roles in tissue-specific gene expression. Many of their functions depend on specific post-translational modifications (PTMs), and in this review, we describe how PTMs govern RUNX DNA binding, transcriptional activity, protein stability, cellular localization, and protein-protein interactions. We also report how these processes can be disrupted in disease settings. Finally, we describe how alterations of RUNX1, or the enzymes that catalyze its post-translational modifications, contribute to hematopoietic malignancies.
authors.affiliation: Sylvester Comprehensive Cancer Center, Miami, FL, 33136, USA.
authors.forename: Ezra
authors.initials: E
authors.lastname: Blumenthal
authors.affiliation: Sylvester Comprehensive Cancer Center, Miami, FL, 33136, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Greenblatt
authors.affiliation: Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Guang
authors.initials: G
authors.lastname: Huang
authors.affiliation: Sylvester Comprehensive Cancer Center, Miami, FL, 33136, USA.
authors.forename: Koji
authors.initials: K
authors.lastname: Ando
authors.affiliation: Sylvester Comprehensive Cancer Center, Miami, FL, 33136, USA.|Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
authors.forename: Ye
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Sylvester Comprehensive Cancer Center, Miami, FL, 33136, USA. snimer@med.miami.edu.|Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, 33136, USA. snimer@med.miami.edu.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Nimer
mesh_terms: D000818:Animals; D050657:Core Binding Factor alpha Subunits / Q000235:genetics* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D060066:Protein Interaction Maps / Q000235:genetics; D011499:Protein Processing, Post-Translational / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D050657:Core Binding Factor alpha Subunits; D004268:DNA-Binding Proteins; D014157:Transcription Factors
keywords: Acetylation; Acute Myeloid Leukemia; CBFβ; Cleidocranial Dysplasia; FPD/AML; Methylation; Phosphorylation; Post-Translational Modifications; RUNX1; RUNX2; RUNX3; Transcriptional Activation; Transcriptional Repression; Ubiquitylation