title: Autoimmune limbic encephalitis with anti-contactin-associated protein-like 2 antibody secondary to pembrolizumab therapy.
abstract: Immune checkpoint inhibitors such as Pembrolizumab are used to restore antitumour immune response. It is important to be vigilant of immune mediated adverse events related to such therapy. We report a case of autoimmune limbic encephalitis with Contactin-Associated Protein-like 2 (CASPR2) antibody secondary to Pembrolizumab therapy for metastatic melanoma.
authors.affiliation: Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. Electronic address: MichaelP.Brown@sa.gov.au.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Brown
authors.affiliation: Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. Electronic address: Pravin.Hissaria@sa.gov.au.
authors.forename: Pravin
authors.initials: P
authors.lastname: Hissaria
authors.affiliation: Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. Electronic address: hsinchiehamy.hsieh@sa.gov.au.
authors.forename: Amy Hc
authors.initials: AH
authors.lastname: Hsieh
authors.affiliation: Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. Electronic address: Chris.Kneebone@sa.gov.au.
authors.forename: Christopher
authors.initials: C
authors.lastname: Kneebone
authors.affiliation: Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. Electronic address: Wilson.vallat@sa.gov.au.
authors.forename: Wilson
authors.initials: W
authors.lastname: Vallat
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D001323:Autoantibodies / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000000981:diagnostic imaging / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D020363:Limbic Encephalitis / Q000000981:diagnostic imaging / Q000276:immunology* / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000276:immunology / Q000628:therapy; D008565:Membrane Proteins / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000276:immunology*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D001323:Autoantibodies; C403049:CNTNAP2 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C582435:pembrolizumab