title: RNA Methylation Clears the Way.
abstract: During the maternal-to-zygotic transition, maternal mRNAs are cleared by multiple distinct but interrelated pathways. A recent study in Nature by Zhao et al. (2017) finds that YTHDF2, a reader of N6- methylation, facilitates maternal mRNA decay, introducing an additional facet of control over transcript fate and developmental reprogramming.
authors.affiliation: Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: Cassandra
authors.initials: C
authors.lastname: Kontur
authors.affiliation: Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: antonio.giraldez@yale.edu.
authors.forename: Antonio
authors.initials: A
authors.lastname: Giraldez
mesh_terms: D018507:Gene Expression Regulation, Developmental; D008745:Methylation; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics; D023121:RNA, Messenger, Stored / Q000235:genetics*; D015053:Zygote
chemical_list: D012333:RNA, Messenger; D023121:RNA, Messenger, Stored