title: Early computed tomography modifications following bronchial thermoplasty in patients with severe asthma.
abstract: Bronchial thermoplasty (BT) is a recent, promising and well-tolerated technique for the treatment of severe asthma. By delivering thermal energy to the airway wall, this procedure can induce early pulmonary opacities seen on computed tomography (CT). We aimed to examine early CT modifications induced by BT and to determine their association with respiratory symptoms.Unenhanced chest CT was performed the day after each BT session in 13 patients with severe asthma, leading to the examination of 38 treated lobes. A total of 15 BT-treated lobes were evaluated in 11 patients at 1 month. The first two patients also underwent CT at 1 week.No symptoms suggestive of pulmonary infection were noted following BT in any patient. Peribronchial consolidations and ground-glass opacities were observed in all treated lobes on day 1, with three lower lobes showing complete collapse. Mild involvement of an adjacent untreated lobe was observed in 12 out of 38 (32%) cases. Opacities had decreased in 5 out of 15 (33%) and disappeared in 10 out of 15 (67%) at 1 month.BT induced early pulmonary peribronchial hyperdensities in all treated lobes. These alterations were unrelated to clinical symptoms and spontaneously decreased or disappeared after 1 month.
authors.affiliation: Dept of Radiology, Bichat Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France marie-pierre.debray@aphp.fr.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Debray
authors.affiliation: Dept of Pneumology A, Bichat Claude Bernard Hospital Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Dombret
authors.affiliation: Inserm UMR1152, Physiopathology and Epidemiology of Respiratory Diseases, Paris, France.|Faculty of Medicine, Paris Diderot University, Bichat Campus, Paris, France.|Laboratory of Excellence, INFLAMEX, Université Sorbonne Paris Cité and DHU FIRE, Paris, France.
authors.forename: Marina
authors.initials: M
authors.lastname: Pretolani
authors.affiliation: Inserm UMR1152, Physiopathology and Epidemiology of Respiratory Diseases, Paris, France.|Faculty of Medicine, Paris Diderot University, Bichat Campus, Paris, France.|Laboratory of Excellence, INFLAMEX, Université Sorbonne Paris Cité and DHU FIRE, Paris, France.|Dept of Pneumology B, Bichat Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Thabut
authors.affiliation: Clinical Investigation Center, Bichat-Claude Bernard University Hospital, Paris, France.
authors.forename: Loubna
authors.initials: L
authors.lastname: Alavoine
authors.affiliation: Dept of Radiology, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France.|Université Paris 13, PRES Sorbonne-Paris-Cité, UPRES EA 2363, Bobigny, France.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Brillet
authors.affiliation: Dept of Pneumology A, Bichat Claude Bernard Hospital Assistance Publique-Hôpitaux de Paris, Paris, France.|Inserm UMR1152, Physiopathology and Epidemiology of Respiratory Diseases, Paris, France.|Faculty of Medicine, Paris Diderot University, Bichat Campus, Paris, France.|Laboratory of Excellence, INFLAMEX, Université Sorbonne Paris Cité and DHU FIRE, Paris, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Taillé
authors.affiliation: Dept of Radiology, Bichat Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.|Faculty of Medicine, Paris Diderot University, Bichat Campus, Paris, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Khalil
authors.affiliation: Dept of Respiratory Diseases, Inserm U1067 and CNRS UMR7733, Aix-Marseille University, Marseille, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Chanez
authors.affiliation: Dept of Pneumology A, Bichat Claude Bernard Hospital Assistance Publique-Hôpitaux de Paris, Paris, France.|Inserm UMR1152, Physiopathology and Epidemiology of Respiratory Diseases, Paris, France.|Faculty of Medicine, Paris Diderot University, Bichat Campus, Paris, France.|Laboratory of Excellence, INFLAMEX, Université Sorbonne Paris Cité and DHU FIRE, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Aubier
mesh_terms: D000328:Adult; D001249:Asthma / Q000000981:diagnostic imaging* / Q000601:surgery*; D001980:Bronchi / Q000601:surgery*; D000074060:Bronchial Thermoplasty; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed