title: A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/β-catenin pathway.
abstract: Obesity is a worldwide medical problem resulting in serious morbidity and mortality involving differentiation of pre-adipocytes into mature adipocytes (adipogenesis). Boron treatment has been reported to be associated with weight reduction in experimental animals; however, its effects on pre-adipocyte differentiation and anti-adipogenic molecular mechanisms are unknown. In this study, we demonstrate the inhibitory activities of boric acid (BA) and sodium pentaborate pentahydrate (NaB) on adipogenesis using common cellular models. Boron treatment repressed the expression of adipogenesis-related genes and proteins, including CCAAT-enhancer-binding protein α and peroxisome proliferator-activated receptor γ, by regulating critical growth factors and the β-catenin, AKT, and extracellular signal-regulated kinase signaling pathways. In addition, although boron treatment did not induce apoptosis in pre-adipocytes, it depressed mitotic clonal expansion by regulation of cell cycle genes. Overall, these data offer promising insights into the prevention/treatment of obesity and associated diseases.
authors.affiliation: Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Kayisdagi Cad. 26 Agustos Yerlesimi, 34755 Atasehir, Istanbul, Turkey; National Cancer Instıtute, CDBL, NIH, Frederıck, MD.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Doğan
authors.affiliation: Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Kayisdagi Cad. 26 Agustos Yerlesimi, 34755 Atasehir, Istanbul, Turkey; National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD. Electronic address: selami.demirci@nih.gov.
authors.forename: Selami
authors.initials: S
authors.lastname: Demirci
authors.affiliation: Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Kayisdagi Cad. 26 Agustos Yerlesimi, 34755 Atasehir, Istanbul, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Apdik
authors.affiliation: Department of Medical Genetics, Yeditepe University Medical School Inonu Mah, Kayisdagi Cad. 26 Agustos Yerlesimi, 34755 Atasehir, Istanbul, Turkey.
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Bayrak
authors.affiliation: Department of Medical Genetics, Yeditepe University Medical School Inonu Mah, Kayisdagi Cad. 26 Agustos Yerlesimi, 34755 Atasehir, Istanbul, Turkey.
authors.forename: Sukru
authors.initials: S
authors.lastname: Gulluoglu
authors.affiliation: Department of Medical Genetics, Yeditepe University Medical School Inonu Mah, Kayisdagi Cad. 26 Agustos Yerlesimi, 34755 Atasehir, Istanbul, Turkey.
authors.forename: Emre Can
authors.initials: EC
authors.lastname: Tuysuz
authors.affiliation: Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia; Riken Innovation Center, Riken, Yokohama, Japan.
authors.forename: Oleg
authors.initials: O
authors.lastname: Gusev
authors.affiliation: Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
authors.forename: Albert A
authors.initials: AA
authors.lastname: Rizvanov
authors.affiliation: Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Kayisdagi Cad. 26 Agustos Yerlesimi, 34755 Atasehir, Istanbul, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Nikerel
authors.affiliation: Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Kayisdagi Cad. 26 Agustos Yerlesimi, 34755 Atasehir, Istanbul, Turkey.
authors.forename: Fikrettin
authors.initials: F
authors.lastname: Şahin
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects; D050156:Adipogenesis / Q000187:drug effects* / Q000235:genetics; D052242:Adiponectin / Q000096:biosynthesis / Q000235:genetics; D000818:Animals; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D001881:Borates / Q000494:pharmacology; D001888:Boric Acids / Q000494:pharmacology; D001896:Boron Compounds / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D018816:Genes, cdc / Q000187:drug effects; D020738:Leptin / Q000096:biosynthesis / Q000235:genetics; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009765:Obesity / Q000188:drug therapy*; D013234:Stem Cells / Q000187:drug effects*; D060449:Wnt Signaling Pathway / Q000187:drug effects*
chemical_list: D052242:Adiponectin; C499919:Adipoq protein, mouse; D019440:Anti-Obesity Agents; D001881:Borates; D001888:Boric Acids; D001896:Boron Compounds; D016207:Cytokines; D020738:Leptin; C032688:boric acid; C538809:sodium pentaborate
keywords: Adipogenesis; Boron; Lipogenesis; PPARγ; β-catenin