title: Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiative.
abstract: BACKGROUND
  Preference-weighted multi-faceted endpoints have the potential to facilitate comparative effectiveness research that incorporates patient preferences. The Older Persons and Informal Caregivers Survey-Composite endpoint (TOPICS-CEP) is potentially a valuable outcome measure for evaluating interventions in geriatric care as it combines multiple outcomes relevant to older persons in a single metric. The objective of this study was to validate TOPICS-CEP across different study settings (general population, primary care and hospital).
  
  
  METHODS
  Data were extracted from TOPICS Minimum Dataset (MDS), a pooled public-access national database with information on older persons throughout the Netherlands. Data of 17,603 older persons were used. Meta-correlations were performed between TOPICS-CEP indexed scores, EuroQol5-D utility scores and Cantril's ladder life satisfaction scores. Mixed linear regression analyses were performed to compare TOPICS-CEP indexed scores between known groups, e.g. persons with versus without depression.
  
  
  RESULTS
  In the complete sample and when stratified by study setting TOPICS-CEP and Cantril's ladder were moderately correlated, whereas TOPICS-CEP and EQ-5D were highly correlated. Higher mean TOPICS-CEP scores were found in persons who were: married, lived independently and had an education at university level. Moreover, higher mean TOPICS-CEP scores were found in persons without dementia, depression, and dizziness with falls, respectively. Similar results were found when stratified by subgroup.
  
  
  CONCLUSIONS
  This study supports that TOPICS-CEP is a robust measure which can potentially be used in broad settings to identify the effect of intervention or of prevention in elderly care.
authors.affiliation: Department of Geriatric Medicine (HP 925), Radboud University Medical Center, Nijmegen, The Netherlands.|Department for Health Evidence (HP133), Radboud University Medical Center, Nijmegen, the Netherlands.|Vilans, Centre of Expertise for Long-Term Care, Utrecht, the Netherlands.
authors.forename: Cynthia S
authors.initials: CS
authors.lastname: Hofman
authors.affiliation: Department of Geriatric Medicine (HP 925), Radboud University Medical Center, Nijmegen, The Netherlands.|Anu Research Centre, University College Cork, Cork, Ireland.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Lutomski
authors.affiliation: Department of Epidemiology (FA41), University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
authors.forename: Han
authors.initials: H
authors.lastname: Boter
authors.affiliation: Department of Internal Medicine, Section of Geriatric Medicine (F4-108), Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: Bianca M
authors.initials: BM
authors.lastname: Buurman
authors.affiliation: Department of Gerontology and Geriatrics (C2-R), Leiden University Medical Centre, Leiden, the Netherlands.
authors.forename: Anton J M
authors.initials: AJ
authors.lastname: de Craen
authors.affiliation: Department for Health Evidence (HP133), Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: Rogier
authors.initials: R
authors.lastname: Donders
authors.affiliation: Department of Geriatric Medicine (HP 925), Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Marcel G M
authors.initials: MG
authors.lastname: Olde Rikkert
authors.affiliation: Department of Geriatric Medicine (HP 925), Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Makai
authors.affiliation: Department of Geriatric Medicine (HP 925), Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: René J F
authors.initials: RJ
authors.lastname: Melis
mesh_terms: D000368:Aged; D017028:Caregivers; D005260:Female; D006801:Humans; D008297:Male