title: Pemphigus Vulgaris and Eosinophilic Esophagitis in a 13-Year-Old Boy: Case Report and Review of the Literature.
abstract: This case report presents a 13-year-old boy referred to the Department of Paediatric Dentistry, Women's and Children's Hospital, Adelaide, South Australia, Australia, with a 5-week history of severe oral ulcerations and significant weight loss of unknown origin. The diagnosis of pemphigus vulgaris was made after histologic and immunofluorescent examination of an intraoral deep incisional biopsy, with eosinophilic esophagitis also diagnosed during the initial upper gastrointestinal endoscopy. The association between pemphigus vulgaris and eosinophilic esophagitis in this case, although previously unreported, is explicable on the basis of dysregulation of desmoglein 1 (DSG1). This case report identifies a new clinical association that could help clinicians identify further such cases and provides insight into the pathogenesis of both conditions.
authors.affiliation: Department of Paediatric Dentistry, Women's and Children's Hospital, Adelaide, South Australia, Australia.|Discipline of Paediatric Dentistry, School of Dentistry, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: Sumant
authors.initials: S
authors.lastname: Gue
authors.affiliation: Discipline of Paediatric Dentistry, School of Dentistry, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia.|Division of Paediatric Surgery, Department of Paediatric Dentistry, Women's and Children's Hospital, Adelaide, South Australia, Australia.
authors.forename: Gwendolyn
authors.initials: G
authors.lastname: Huang
authors.affiliation: Department of Surgical Pathology, Women's and Children's Hospital, Adelaide, South Australia, Australia.|University Discipline of Pathology, University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: Lynette
authors.initials: L
authors.lastname: Moore
authors.affiliation: Department of Paediatric Gastroenterology, Women's and Children's Hospital, Adelaide, South Australia, Australia.|Discipline of Paediatrics, University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Hammond
authors.affiliation: Discipline of Paediatrics, University of Adelaide, Adelaide, South Australia, Australia.|Department of Paediatric Rheumatology, Women's and Children's Hospital, Adelaide, South Australia, Australia.
authors.forename: Christina A
authors.initials: CA
authors.lastname: Boros
mesh_terms: D000293:Adolescent; D057765:Eosinophilic Esophagitis / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008297:Male; D010392:Pemphigus / Q000150:complications* / Q000473:pathology*