title: Quantitative measurement of indomethacin crystallinity in indomethacin-silica gel binary system using differential scanning calorimetry and X-ray powder diffractometry.
abstract: Differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRPD) methods were developed for the quantitative analysis of the crystallinity of indomethacin (IMC) in IMC and silica gel (SG) binary system. The DSC calibration curve exhibited better linearity than that of XRPD. No phase transformation occurred in the IMC-SG mixtures during DSC measurement. The major sources of error in DSC measurements were inhomogeneous mixing and sampling. Analyzing the amount of IMC in the mixtures using high-performance liquid chromatography (HPLC) could reduce the sampling error. DSC demonstrated greater sensitivity and had less variation in measurement than XRPD in quantifying crystalline IMC in the IMC-SG binary system.
authors.affiliation: School of Pharmacy, University of Maryland, 20 North Pine Street, 21201, Baltimore, MD. xpan100_2000@yahoo.com.|Wyeth, 401 North Middletown Road, Building 230/1073, 10965, Pearl River, NY. xpan100_2000@yahoo.com.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Pan
authors.affiliation: Genta, 2 Connell Drive, 07922, Berkeley Heights, NJ.
authors.forename: Thomas
authors.initials: T
authors.lastname: Julian
authors.affiliation: School of Pharmacy, University of Maryland, 20 North Pine Street, 21201, Baltimore, MD.
authors.forename: Larry
authors.initials: L
authors.lastname: Augsburger
keywords: Differential scanning calorimetry; X-ray powder diffractometry; amorphization; crystallinity; indomethacin; quantitative analysis; silica gel