title: Photoreversibility and Biocompatibility of Polydimethylsiloxane-Coumarin as Adjustable Intraocular Lens Material.
abstract: Polydimethylsiloxane (PDMS) constitutes an interesting material for a variety of biomedical applications, especially as intraocular lenses (IOLs), for its excellent transparency. In this work, a photoreversible PDMS-coumarin network, whose shape and properties can be adjusted postoperatively in a noninvasive manner, is developed. The synthesis of PDMS-coumarin is achieved by amidation of a coumarin acid chloride derivative with amine-functionalized PDMSs. Under exposure of λ > 300 nm, these polymers can be cured by dimerization of coumarin. The cured polymers can be uncrosslinked via photocleavage of cyclobutane dimers upon illumination at λ < 290 nm. The diffusion of linear PDMSs in a crosslinked network and the controlled shape modification are studied, which demonstrate that these polymers are good candidates for adjustable IOL application. IOL disks prepared from these materials show high hydrophobicity and good transparency. In vitro cytotoxicity, lens epithelial cell adhesion assays, and rabbit host reaction against implanted disks demonstrate the biocompatibility of the polymer.
authors.affiliation: Center for Education and Research on Macromolecules (CERM), Chemistry Department, University of Liege, B6 Sart-Tilman, B-4000, Liege, Belgium.
authors.forename: Rachid
authors.initials: R
authors.lastname: Jellali
authors.affiliation: Laboratory of Mammalian Cell Culture (GIGA-R), University of Liege, B6 Sart-Tilman, B-4000, Liege, Belgium.
authors.forename: Virginie
authors.initials: V
authors.lastname: Bertrand
authors.affiliation: Center for Education and Research on Macromolecules (CERM), Chemistry Department, University of Liege, B6 Sart-Tilman, B-4000, Liege, Belgium.
authors.forename: Michaël
authors.initials: M
authors.lastname: Alexandre
authors.affiliation: Laboratory of Mammalian Cell Culture (GIGA-R), University of Liege, B6 Sart-Tilman, B-4000, Liege, Belgium.
authors.forename: Nancy
authors.initials: N
authors.lastname: Rosière
authors.affiliation: Département Clinique des Animaux de Compagnie et des Équidés, University of Liège, B44 Sart-Tilman, B-4000, Liege, Belgium.
authors.forename: Magda
authors.initials: M
authors.lastname: Grauwels
authors.affiliation: Laboratory of Mammalian Cell Culture (GIGA-R), University of Liege, B6 Sart-Tilman, B-4000, Liege, Belgium.
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: De Pauw-Gillet
authors.affiliation: Center for Education and Research on Macromolecules (CERM), Chemistry Department, University of Liege, B6 Sart-Tilman, B-4000, Liege, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Jérôme
mesh_terms: D000818:Animals; D002460:Cell Line; D003374:Coumarins / Q000737:chemistry*; D005347:Fibroblasts / Q000378:metabolism*; D007910:Lenses, Intraocular; D008422:Materials Testing; D051379:Mice; D012828:Silicones / Q000737:chemistry*
chemical_list: D003374:Coumarins; D012828:Silicones; C078211:polymethylsiloxane; C030123:coumarin
keywords: adjustable intraocular lens; biocompatibility; coumarin; photoreversible crosslinking; polydimethylsiloxane