title: Does familial risk for alcohol use disorder predict alcohol hangover?
abstract: OBJECTIVE
  Positive family history of alcohol use disorder (FHP), a variable associated with propensity for alcohol use disorder (AUD), has been linked with elevated hangover frequency and severity, after controlling for alcohol use. This implies that hangover experiences may be related to AUD. However, inadequate control of alcohol consumption levels, low alcohol dose and testing for hangover during the intoxication phase detract from these findings. Here, we present further data pertinent to understanding the relationship between family history and alcohol hangover.
  
  
  METHODS
  Study 1 compared past year hangover frequency in a survey of 24 FHP and 118 family history negative (FHN) individuals. Study 2 applied a quasi-experimental naturalistic approach assessing concurrent hangover severity in 17 FHP and 32 FHN individuals the morning after drinking alcohol. Both studies applied statistical control for alcohol consumption levels.
  
  
  RESULTS
  In Study 1, both FHP status and estimated blood alcohol concentration on the heaviest drinking evening of the past month predicted the frequency of hangover symptoms experienced over the previous 12 months. In Study 2, estimated blood alcohol concentration the previous evening predicted hangover severity but FHP status did not.
  
  
  CONCLUSIONS
  FHP, indicating familial risk for AUD, was not associated with concurrent hangover severity but was associated with increased estimates of hangover frequency the previous year.
authors.affiliation: Keele University, Keele, Staffordshire, ST5 5BG, Newcastle, UK. r.stephens@keele.ac.uk.
authors.forename: Richard
authors.identifier: http://orcid.org/0000-0002-5851-8975
authors.initials: R
authors.lastname: Stephens
authors.affiliation: Keele University, Keele, Staffordshire, ST5 5BG, Newcastle, UK.
authors.forename: Kara
authors.initials: K
authors.lastname: Holloway
authors.affiliation: Keele University, Keele, Staffordshire, ST5 5BG, Newcastle, UK.
authors.forename: James A
authors.initials: JA
authors.lastname: Grange
authors.affiliation: Psychology Department, University of Central Lancashire (UCLAN), Fylde Rd, PR1 2HE, Preston, UK.
authors.forename: Lauren
authors.initials: L
authors.lastname: Owen
authors.affiliation: Health and Safety Laboratory, Buxton, UK.
authors.forename: Kate
authors.initials: K
authors.lastname: Jones
authors.affiliation: Acadia University, Wolfville, Canada.
authors.forename: Darren
authors.initials: D
authors.lastname: Kruisselbrink
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000097:blood / Q000235:genetics; D000435:Alcoholic Intoxication / Q000097:blood* / Q000175:diagnosis / Q000235:genetics*; D000437:Alcoholism / Q000097:blood* / Q000175:diagnosis / Q000235:genetics*; D000067401:Blood Alcohol Content; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012307:Risk Factors; D057566:Self Report; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000067401:Blood Alcohol Content
keywords: Alcohol hangover frequency; Alcohol hangover severity; Alcohol use disorder (AUD); Concurrent hangover; Family history