title: Expanded type III effector recognition by the ZAR1 NLR protein using ZED1-related kinases.
abstract: Nucleotide-binding domain and leucine-rich repeat domain-containing (NLR) proteins are sentinels of plant immunity that monitor host proteins for perturbations induced by pathogenic effector proteins. Here we show that the Arabidopsis ZAR1 NLR protein requires the ZRK3 kinase to recognize the Pseudomonas syringae type III effector (T3E) HopF2a. These results support the hypothesis that ZAR1 associates with an expanded ZRK protein family to broaden its effector recognition spectrum.
authors.affiliation: Department of Cell &Systems Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada.
authors.forename: Derek
authors.initials: D
authors.lastname: Seto
authors.affiliation: Department of Cell &Systems Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada.
authors.forename: Noushin
authors.initials: N
authors.lastname: Koulena
authors.affiliation: Department of Cell &Systems Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada.
authors.forename: Timothy
authors.initials: T
authors.lastname: Lo
authors.affiliation: Department of Cell &Systems Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Menna
authors.affiliation: Department of Cell &Systems Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada.|Centre for the Analysis of Genome Evolution &Function, University of Toronto, Toronto, Ontario M5S 3B2, Canada.
authors.forename: David S
authors.identifier: 0000-0001-8479-3869
authors.initials: DS
authors.lastname: Guttman
authors.affiliation: Department of Cell &Systems Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada.|Centre for the Analysis of Genome Evolution &Function, University of Toronto, Toronto, Ontario M5S 3B2, Canada.
authors.forename: Darrell
authors.initials: D
authors.lastname: Desveaux
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics* / Q000276:immunology*; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D000070576:NLR Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D057865:Plant Immunity; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D044224:Pseudomonas syringae / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins
chemical_list: D029681:Arabidopsis Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D000070576:NLR Proteins; D017346:Protein Serine-Threonine Kinases; C551312:ZAR1 protein, Arabidopsis; D047908:Intracellular Signaling Peptides and Proteins; C000627964:ZRK3 protein, Arabidopsis