title: Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1.
abstract: New Ru(ii)-caged abiraterone complexes were synthesized that exhibit strong absorption in the visible region and release the steroidal CYP17A1 inhibitor abiraterone upon exposure to low energy visible light in buffer and prostate cancer cells. Photoinduced release results in abiraterone binding to its CYP17A1 target in an inhibitory mode.
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu.
authors.forename: Ao
authors.initials: A
authors.lastname: Li
authors.affiliation: Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Rahul
authors.initials: R
authors.lastname: Yadav
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Jessica K
authors.identifier: http://orcid.org/0000-0003-2505-0955
authors.initials: JK
authors.lastname: White
authors.affiliation: Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA.
authors.forename: Mackenzie K
authors.initials: MK
authors.lastname: Herroon
authors.affiliation: Department of Chemistry, Binghamton University, Binghamton, New York 13902, USA.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Callahan
authors.affiliation: Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA.
authors.forename: Izabela
authors.initials: I
authors.lastname: Podgorski
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Claudia
authors.initials: C
authors.lastname: Turro
authors.affiliation: Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Emily E
authors.initials: EE
authors.lastname: Scott
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA.
authors.forename: Jeremy J
authors.identifier: http://orcid.org/0000-0001-5196-7463
authors.initials: JJ
authors.lastname: Kodanko
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D065607:Cytochrome P-450 Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008027:Light; D008297:Male; D015394:Molecular Structure; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D012428:Ruthenium / Q000737:chemistry / Q000494:pharmacology*; D013254:Steroid 17-alpha-Hydroxylase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D065607:Cytochrome P-450 Enzyme Inhibitors; D012428:Ruthenium; C501892:CYP17A1 protein, human; D013254:Steroid 17-alpha-Hydroxylase