title: Lung Volume Reduction Coils as a Novel Bronchoscopic Treatment for Emphysema.
abstract: Chronic obstructive pulmonary disease remains a major cause of morbidity and mortality worldwide. Despite regular advances in pharmacology, there remains great potential for addressing structural deficiencies, especially in emphysema. The loss of alveolar attachments to small bronchial tubes results in diffuse loss of elastic recoil and airway collapse during exhalation. This appears physiologically as hyperinflation of lung volumes with flattened diaphragms and significantly elevated residual volumes (RV) on pulmonary function testing (predicted RV > 175%).
authors.affiliation: Houston Methodist Hospital, Houston, Texas.
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Connolly
mesh_terms: D000497:Alloys; D001999:Bronchoscopy / Q000009:adverse effects / Q000295:instrumentation*; D004548:Elasticity; D004867:Equipment Design; D006801:Humans; D008168:Lung / Q000503:physiopathology / Q000601:surgery*; D008176:Lung Volume Measurements; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D011656:Pulmonary Emphysema / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000497:Alloys; C013616:nitinol
keywords: COPD; chronic obstructive pulmonary disease; emphysema; lung volume reduction coils; nitinol coils