title: Olmesartan-Induced Enteropathy.
abstract: Olmesartan-induced enteropathy mimics celiac disease clinically and pathologically. As in celiac disease, the pathologic findings are villous atrophy and increased intraepithelial lymphocytes. Clinical presentation of olmesartan-induced enteropathy includes diarrhea, weight loss, and nausea. In contrast to celiac disease, tissue transglutaminase is not elevated and there is no response to a gluten-free diet. Including this entity in the differential diagnosis of sprue-like enteropathy is critical for its early diagnosis since replacing olmesartan with an alternative antihypertensive drug can simplify the diagnostic workup and provide both clinical and histologic improvement.
authors.affiliation: Houston Methodist Hospital, Houston, Texas.
authors.forename: Abimbola
authors.initials: A
authors.lastname: Adike
authors.affiliation: University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Juan
authors.initials: J
authors.lastname: Corral
authors.affiliation: Alpert Medical School, Brown University, Providence, Rhode Island.
authors.forename: David
authors.initials: D
authors.lastname: Rybnicek
authors.affiliation: University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Daniel
authors.initials: D
authors.lastname: Sussman
authors.affiliation: Alpert Medical School, Brown University, Providence, Rhode Island.
authors.forename: Samir
authors.initials: S
authors.lastname: Shah
authors.affiliation: Houston Methodist Hospital, Houston, Texas.
authors.forename: Eamonn
authors.initials: E
authors.lastname: Quigley
mesh_terms: D000368:Aged; D047228:Angiotensin II Type 1 Receptor Blockers / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D001284:Atrophy; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000139:chemically induced; D057915:Drug Substitution; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007093:Imidazoles / Q000009:adverse effects*; D007410:Intestinal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008871:Microvilli / Q000187:drug effects / Q000473:pathology; D011237:Predictive Value of Tests; D013777:Tetrazoles / Q000009:adverse effects*; D015431:Weight Loss / Q000187:drug effects
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D007093:Imidazoles; D013777:Tetrazoles; C437965:olmesartan
keywords: celiac disease; diarrhea; olmesartan-induced enteropathy