title: Squamous cell carcinoma arising in a multiple verrucous epidermal nevus.
abstract: Verrucous epidermal nevi are hamartomatous lesions of the epidermis that, unlike other epidermal nevi (such as sebaceous nevus or nevus comedonicus), are rarely associated with malignant neoplasms. The majority of squamous cell carcinoma develop in linear or multiple epidermal nevus and rarely in solitary epidermal nevus. In general, the prognosis is favorable. We report a case of well-differentiated invasive squamous cell carcinoma arising from a multiple verrucous epidermal nevus. Although there is no consensus on prophylactic removal of epidermal nevus, its removal and biopsy should be considered if changes occur.
authors.affiliation: Universidade Federal de São Paulo (UNIFESP) - São Paulo (SP), Brazil.
authors.forename: Samira
authors.initials: S
authors.lastname: Yarak
authors.affiliation: Universidade Federal de São Paulo (UNIFESP) - São Paulo (SP), Brazil.
authors.forename: Taila Yuri Siqueira
authors.initials: TY
authors.lastname: Machado
authors.affiliation: Universidade Federal de São Paulo (UNIFESP) - São Paulo (SP), Brazil.
authors.forename: Marilia Marufuji
authors.initials: MM
authors.lastname: Ogawa
authors.affiliation: Private clinic - Luanda, Angola.
authors.forename: Mirian Luzia da Silva
authors.initials: ML
authors.lastname: Almeida
authors.affiliation: Universidade Federal de São Paulo (UNIFESP) - São Paulo (SP), Brazil.
authors.forename: Milvia Maria Simões E Silva
authors.initials: MM
authors.lastname: Enokihara
authors.affiliation: Universidade Federal de São Paulo (UNIFESP) - São Paulo (SP), Brazil.
authors.forename: Adriana Maria
authors.initials: AM
authors.lastname: Porro
mesh_terms: D000328:Adult; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000473:pathology; D054000:Nevus, Sebaceous of Jadassohn / Q000150:complications* / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D012883:Skin Ulcer / Q000473:pathology