title: The molecular biology of pelvi-ureteric junction obstruction.
abstract: Over recent years routine ultrasound scanning has identified increasing numbers of neonates as having hydronephrosis and pelvi-ureteric junction obstruction (PUJO). This patient group presents a diagnostic and management challenge for paediatric nephrologists and urologists. In this review we consider the known molecular mechanisms underpinning PUJO and review the potential of utilising this information to develop novel therapeutics and diagnostic biomarkers to improve the care of children with this disorder.
authors.affiliation: Bristol Renal Group, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK. laura.jackson@bristol.ac.uk.|Bristol Royal Hospital for Children, Bristol, UK. laura.jackson@bristol.ac.uk.
authors.forename: Laura
authors.identifier: 0000-0002-8243-6566
authors.initials: L
authors.lastname: Jackson
authors.affiliation: Bristol Royal Hospital for Children, Bristol, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Woodward
authors.affiliation: Bristol Renal Group, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK.|Bristol Royal Hospital for Children, Bristol, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Coward
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D006801:Humans; D006869:Hydronephrosis / Q000151:congenital* / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D007682:Kidney Pelvis / Q000473:pathology; D008967:Molecular Biology; D058990:Molecular Targeted Therapy / Q000379:methods; D021782:Multicystic Dysplastic Kidney / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D009154:Mutation; D014513:Ureter / Q000473:pathology; D014517:Ureteral Obstruction / Q000235:genetics / Q000378:metabolism* / Q000628:therapy
chemical_list: D015415:Biomarkers
keywords: Aetiology; Biomarker; Hydronephrosis; Molecular biology; Pelvi-ureteric junction obstruction