title: Few-Layer Graphdiyne Nanosheets Applied for Multiplexed Real-Time DNA Detection.
abstract: Despite recent progress in 2D nanomaterials-based biosensing, it remains challenging to achieve sensitive and high selective detection. This study develops few-layer graphdiyne (GD) nanosheets (NSs) that are used as novel sensing platforms for a variety of fluorophores real-time detection of DNA with low background and high signal-to-noise ratio, which show a distinguished fluorescence quenching ability and different affinities toward single-stranded DNA and double-stranded DNA. Importantly, for the first time, a few-layer GD NSs-based multiplexed DNA sensor is developed.
authors.affiliation: State Key Laboratory of Biochemical Engineering, CAS Center for Excellence in Nanoscience, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 Beiertiao, Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Nargish
authors.initials: N
authors.lastname: Parvin
authors.affiliation: State Key Laboratory of Biochemical Engineering, CAS Center for Excellence in Nanoscience, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 Beiertiao, Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Jin
authors.affiliation: Department of Physical Chemistry, School of Metallurgical and Ecological Engineering, University of Science and Technology Beijing, No. 30, Xueyuan Road, Haidian District, Beijing, 100083, P. R. China.
authors.forename: Yanze
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Physical Chemistry, School of Metallurgical and Ecological Engineering, University of Science and Technology Beijing, No. 30, Xueyuan Road, Haidian District, Beijing, 100083, P. R. China.
authors.forename: Ranbo
authors.initials: R
authors.lastname: Yu
authors.affiliation: Institute of Advanced Materials, Nanjing Tech University, Chemical Engineering Block, 5 Xinmofan Road, Nanjing, 210009, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zheng
authors.affiliation: Institute of Advanced Materials, Nanjing Tech University, Chemical Engineering Block, 5 Xinmofan Road, Nanjing, 210009, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Huang
authors.affiliation: School of Materials Science and Engineering, Nanjing University of Posts and Telecommunications, No. 9 Wenyuan Road, Nanjing, 210046, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Materials Science and Engineering, Nanjing University of Posts and Telecommunications, No. 9 Wenyuan Road, Nanjing, 210046, P. R. China.
authors.forename: Lianhui
authors.initials: L
authors.lastname: Wang
authors.affiliation: Center for Programmable Materials, School of Materials Science and Engineering, Nanyang Technological University, No. 50 Nanyang Avenue, Singapore, 639798, Singapore.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Institute of Chemistry, Chinese Academy of Sciences, Zhongguancun North First Street 2, 100190, Beijing, P. R. China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Gao
authors.affiliation: Centre for Clean Environment and Energy, Gold Coast Campus, Griffith University, Queensland, 4222, Australia.
authors.forename: Huijun
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Science and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, China.
authors.forename: Wenping
authors.initials: W
authors.lastname: Hu
authors.affiliation: Institute of Chemistry, Chinese Academy of Sciences, Zhongguancun North First Street 2, 100190, Beijing, P. R. China.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Biochemical Engineering, CAS Center for Excellence in Nanoscience, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 Beiertiao, Zhongguancun, Beijing, 100190, P. R. China.|Centre for Clean Environment and Energy, Gold Coast Campus, Griffith University, Queensland, 4222, Australia.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
mesh_terms: D015374:Biosensing Techniques; D004247:DNA; D004277:DNA, Single-Stranded; D049329:Nanostructures; D013050:Spectrometry, Fluorescence
chemical_list: D004277:DNA, Single-Stranded; D004247:DNA
keywords: biosensing; fluorescence quenching; graphdiyne nanosheets; real-time detection