title: Release properties of atelocollagen-gelatin complexes as carriers for local administration of fluvastatin.
abstract: The aim of this study was to investigate properties of atelocollagen/gelatin complexes (AC/Gel) and their characteristics of sustained statin release, to assess the utility of AC/Gel. AC/Gel were prepared by changing the mixing ratio of AC (0 to 40% of AC). Analysis of spectra of fluvastatin (Flu), gelatin (Gel), and Flu with Gel complex using a Fourier transform-infrared spectrometer indicates that Flu was bound to Gel through a bond involving the carboxyl and amino groups. Evaluation of characteristics of sustained release of Flu from the AC/Gel using an ultraviolet-visible spectrophotometer showed that the release rate of Flu decreased with increasing the AC content. The histological evaluation using of Sprague-Dawley rats suggest that, unlike the pure Gel sponge, the AC/Gel was not absorbed in an early stage. Therefore, the present study showed that sustained Flu release can be controlled by using an AC/Gel, suggesting the utility of this composite material.
authors.affiliation: Department of Oral and Maxillofacial Implantology, Tokyo Dental College.|Division of Oral Implants Research, Oral Health Science Center, Tokyo Dental College.
authors.forename: Koichi
authors.initials: K
authors.lastname: Kida
authors.affiliation: Division of Oral Implants Research, Oral Health Science Center, Tokyo Dental College.|Department of Pharmacology, Tokyo Dental College.
authors.forename: Koji
authors.initials: K
authors.lastname: Tanabe
authors.affiliation: Department of Oral and Maxillofacial Implantology, Tokyo Dental College.|Division of Oral Implants Research, Oral Health Science Center, Tokyo Dental College.
authors.forename: Hodaka
authors.initials: H
authors.lastname: Sasaki
authors.affiliation: Department of Oral and Maxillofacial Implantology, Tokyo Dental College.|Division of Oral Implants Research, Oral Health Science Center, Tokyo Dental College.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Furuya
authors.affiliation: Division of Oral Implants Research, Oral Health Science Center, Tokyo Dental College.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Miura
authors.affiliation: Division of Oral Implants Research, Oral Health Science Center, Tokyo Dental College.
authors.forename: Masao
authors.initials: M
authors.lastname: Yoshinari
authors.affiliation: Department of Oral and Maxillofacial Implantology, Tokyo Dental College.|Division of Oral Implants Research, Oral Health Science Center, Tokyo Dental College.
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Yajima
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D005229:Fatty Acids, Monounsaturated; D000077340:Fluvastatin; D005780:Gelatin; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D008422:Materials Testing; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D000077340:Fluvastatin; D005780:Gelatin
keywords: Atelocollagen; Controlled release; Fluvastatin; Gelatin; Regeneration