title: Genetic Obesity Risk and Attenuation Effect of Physical Fitness in Mexican-Mestizo Population: a Case-Control Study.
abstract: We analyzed commonly reported European and Asian obesity-related gene variants in a Mexican-Mestizo population through each single nucleotide polymorphism (SNP) and a genetic risk score (GRS) based on 23 selected SNPs. Study subjects were physically active Mexican-Mestizo adults (n  =  608) with body mass index (BMI) values from 18 to 55 kg/m2. For each SNP and for the GRS, logistic models were performed to test for simple SNP associations with BMI, fat mass percentage (FMP), waist circumference (WC), and the interaction with VO2maxand muscular endurance (ME). To further understand the SNP or GRS*physical fitness components, generalized linear models were performed. Obesity risk was significantly associated to 6 SNPs (ADRB2 rs1042713, APOB rs512535, PPARA rs1800206, TNFA rs361525, TRHR rs7832552 and rs16892496) after adjustment by gender, age, ancestry, VO2max, and ME. ME attenuated the influence of APOB rs512535 and TNFA rs361525 on obesity risk in FMP. WC was significantly associated to GRS. Both ME and VO2maxattenuated GRS effect on WC. We report associations for 6 out of 23 SNPs and for the GRS, which confer obesity risk, a novel finding for Mexican-Mestizo physically active population. Also, the importance of including physical fitness components variables in obesity genetic risk studies is highlighted, with special regard to intervention purposes.
authors.affiliation: Institute of Biomedical Sciences Department of Surgery, Faculty of Medicine, University of São Paulo, Brasil.|Metric Laboratory, Sport City, SA de CV, Grupo Martí, Mexico City, Mexico.
authors.forename: Paula
authors.initials: P
authors.lastname: Costa-Urrutia
authors.affiliation: Metric Laboratory, Sport City, SA de CV, Grupo Martí, Mexico City, Mexico.
authors.forename: Carolina
authors.initials: C
authors.lastname: Abud
authors.affiliation: Departamento de Ecología y Evolución, Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay.
authors.forename: Valentina
authors.initials: V
authors.lastname: Franco-Trecu
authors.affiliation: Departamento de Genética, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
authors.forename: Valentina
authors.initials: V
authors.lastname: Colistro
authors.affiliation: Laboratorio de Medicina Genómica del Hospital Regional Lic, Adolfo López Mateos, Mexico City, Mexico.
authors.forename: Martha Eunice
authors.initials: ME
authors.lastname: Rodríguez-Arellano
authors.affiliation: Departamento de Investigación en Virología y Micología, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
authors.forename: Joel
authors.initials: J
authors.lastname: Vázquez-Pérez
authors.affiliation: División de Inmunogenética, Departamento de Trasplantes, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
authors.affiliation: Institute of Biomedical Sciences Department of Surgery, Faculty of Medicine, University of São Paulo, Brasil.
authors.forename: Marilia
authors.initials: M
authors.lastname: Seelaender
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008800:Mexico; D009765:Obesity / Q000235:genetics*; D010101:Oxygen Consumption / Q000235:genetics; D010807:Physical Endurance; D010809:Physical Fitness; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors
keywords: Obesity; SNP; VO2max; fitness; muscular endurance