title: Anakinra use during pregnancy: Report of a case with Familial Mediterranean Fever and infertility.
abstract: Familial Mediterranean fever (FMF), affecting people of Mediterranean origin, is an endemic and sometimes problematic disease because of colchicine resistance/intolerance, with relative lack of treatment alternatives, and disease- or treatment-related issues, such as subfertility. Anakinra, being a rational and effective treatment alternative, has no conclusive human pregnancy data. Here we report a case of FMF with infertility who became pregnant with in vitro fertilization (IVF) under treatment with anakinra, along with the pregnancy outcome.
authors.affiliation: Department of Internal Medicine, Ankara University School of Medicine, İbn-i Sina Hospital, Ankara, Turkey.
authors.forename: Ufuk
authors.initials: U
authors.lastname: İlgen
authors.affiliation: Department of Rheumatology, Yıldırım Beyazıt University Medical School, Atatürk Research and Training Hospital, Ankara, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Küçükşahin
keywords: Anakinra; Familial Mediterranean Fever; interleukin-1β; pregnancy