title: [Clinical and Economic Analysis Riotsiguata in Patients With Unresectable or Residual Chronic Thromboembolic Pulmonary Hypertension].
abstract: OBJECTIVE
  to undertake economic evaluation of riociguat in comparison with standard practice of treating patients with inoperable or residual chronic thromboembolic pulmonary hypertension (CTEPH) in Russian healthcare.
  
  
  METHODS
  Standard practice was revealed by means of peer interview. It comprised bosentan monotherapy with addition of sildenafil in case of disease progression. Difference in efficacy between riociguat and bosentan was established through the indirect comparison based on the results of randomized controlled trials. Difference in costs of CTEPH treatment with riociguat and standard practice eas estimated in the Markov model that simulated changes in disease functional class (FC). Direct medical costs were considered and included drugs prescriptions, in-patient and out-patient medical care. Probabilistic sensitivity analysis was conducted.
  
  
  RESULTS
  The results of indirect comparison suggest statistically significant higher probability of favorable outcomes in case of treatment with riociguat: improvement by more or equal 1 FC (difference in proportions =14.8% with 95% confidence interval from 0.1 to 29.5; p=0.048) and increase of distance in 6-minute walking distance (mean difference =42.9 m with 95% confidence interval from 10.5 to 75.3; p=0.009). In base-case scenario difference in costs between riociguat and standard practice was 60 646.15 RUB per 1 patient per year in favor of the former. Riociguat costs were lower in 94.4% of sensitivity analysis cycles. In 72.5% of sensitivity analysis cycles costs difference in favor of riociguat was at least half of that in in base-case. In 47.3% of sensitivity analysis costs difference in favor of riociguat was equal or higher to that in base-case.
  
  
  CONCLUSIONS
  The results of modeling suggest that in Russian healthcare treatment of CTEPH with riociguat is characterized by higher efficacy at lower costs.
authors.affiliation: The Russian Presidental Acadaemy of National Economy and Public Administration, 119571 82, bild.1, Vernadsky Prospekt, Moscow, Russia Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulaton Pathology, 15, Rechkunovskaya str., 630055 Novosibirsk, Russia.
authors.forename: V
authors.initials: V
authors.lastname: Avksentyev M
authors.affiliation: The Russian Presidental Acadaemy of National Economy and Public Administration, 119571 82, bild.1, Vernadsky Prospekt, Moscow, Russia Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulaton Pathology, 15, Rechkunovskaya str., 630055 Novosibirsk, Russia.
authors.forename: M
authors.initials: M
authors.lastname: Chernyavskiy A
authors.affiliation: The Russian Presidental Acadaemy of National Economy and Public Administration, 119571 82, bild.1, Vernadsky Prospekt, Moscow, Russia Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulaton Pathology, 15, Rechkunovskaya str., 630055 Novosibirsk, Russia.
authors.forename: A
authors.initials: A
authors.lastname: Pyadushkin E