title: Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer.
abstract: OBJECTIVE
  To explore the correlation of the primary tumor's maximum standardized uptake value (SUVmax) and minimum apparent diffusion coefficient (ADCmin) with clinicopathologic features, and to determine their predictive power in endometrial cancer (EC).
  
  
  METHODS
  A total of 45 patients who had undergone staging surgery after a preoperative evaluation with18F-fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) and diffusion-weighted magnetic resonance imaging (DW-MRI) were included in a prospective case-series study with planned data collection. Multiple linear regression analysis was used to determine the correlations between the study variables.
  
  
  RESULTS
  The mean ADCminand SUVmaxvalues were determined as 0.72±0.22 and 16.54±8.73, respectively. A univariate analysis identified age, myometrial invasion (MI) and lymphovascular space involvement (LVSI) as the potential factors associated with ADCminwhile it identified age, stage, tumor size, MI, LVSI and number of metastatic lymph nodes as the potential variables correlated to SUVmax. In multivariate analysis, on the other hand, MI was the only significant variable that correlated with ADCmin(p=0.007) and SUVmax(p=0.024). Deep MI was best predicted by an ADCmincutoff value of ≤0.77 [93.7% sensitivity, 48.2% specificity, and 93.0% negative predictive value (NPV)] and SUVmaxcutoff value of >20.5 (62.5% sensitivity, 86.2% specificity, and 81.0% NPV); however, the two diagnostic tests were not significantly different (p=0.266).
  
  
  CONCLUSIONS
  Among clinicopathologic features, only MI was independently correlated with SUVmaxand ADCmin. However, the routine use of18F-FDG PET/CT or DW-MRI cannot be recommended at the moment due to less than ideal predictive performances of both parameters.
authors.forename: Evrim
authors.initials: E
authors.lastname: Sürer Budak
authors.forename: Tayfun
authors.initials: T
authors.lastname: Toptaş
authors.affiliation: Akdeniz University Faculty of Medicine, Department of Nuclear Medicine, Antalya, Turkey Phone: +90 532 638 06 54 E-mail: afunda@akdeniz.edu.tr.
authors.forename: Funda
authors.initials: F
authors.lastname: Aydın
authors.forename: Ali Ozan
authors.initials: AO
authors.lastname: Öner
authors.forename: Can
authors.initials: C
authors.lastname: Çevikol
authors.forename: Tayup
authors.initials: T
authors.lastname: Şimşek