title: Management strategies for neoplastic and vascular brain lesions presenting during pregnancy: A series of 29 patients.
abstract: BACKGROUND
  The occurrence of a brain tumor or intracranial vascular lesion during pregnancy is a rare event, but when it happens, it jeopardizes the lives of both the mother and infant. It also creates challenges of a neurosurgical, obstetric, and ethical nature. A multidisciplinary approach should be used for their care.
  
  
  METHODS
  Between 1986 and 2015, 12 pregnant women diagnosed with brain tumors and 17 women with intracranial vascular lesion underwent treatment at the Neurosurgery Department of the Servidores do Estado Hospital and Rede D'Or/São Luis. The Neurosurgery Department teamed up with Obstetrics Anesthesiology Departments in establishing the procedures. The patients' records, surgical descriptions, imaging studies, and histopathological material were reviewed.
  
  
  RESULTS
  Among 12 patients presenting with brain tumors, there were neither operative mortality nor fetal deaths. Among the vascular lesions, aneurysm rupture was responsible for bleeding in 6 instances. Arteriovenous malformation was diagnosed in 7 patients. In this subgroup, the maternal and fetal mortality rates were 11.7% and 23.7%, respectively.
  
  
  CONCLUSIONS
  We can assert that the association between a brain tumor and vascular lesions with pregnancy is a very unusual event, which jeopardizes both the lives of the mother and infant. It remains incompletely characterized due to the rare nature of these potentially devastating events. Knowing the exact mechanism responsible for the interaction of pregnancy and with these lesions will improve the treatment of these patients.
authors.affiliation: Neurosurgical and Obstetrics Departments of Servidores do Estado Hospital, RJ, Brazil.
authors.forename: Celestino Esteves
authors.initials: CE
authors.lastname: Pereira
authors.affiliation: Neurosurgical and Obstetrics Departments of Servidores do Estado Hospital, RJ, Brazil.
authors.forename: Jose Carlos
authors.initials: JC
authors.lastname: Lynch
keywords: Arteriovenous malformation; brain tumor; cerebral aneurysm; pregnancy