title: Diagnostic performance of the Gynecology Imaging Reporting and Data System for malignant adnexal masses.
abstract: OBJECTIVE
  To evaluate the Gynecology Imaging Reporting and Data System (GI-RADS) for diagnosis of malignant adnexal masses in a Chinese population.
  
  
  METHODS
  A retrospective study was conducted of patients who underwent evaluation of suspected adnexal masses at a hospital in Tianjin, China, between January 1, 2015, and January 31, 2016. Ultrasonographic diagnosis was based on the GI-RADS classification-a standardized summary of imaging data that estimates the risk of malignancy-and compared with the final pathological diagnosis.
  
  
  RESULTS
  Among 242 patients, thick wall, solid papillary projection, solid area, central blood flow, ascites, and GI-RADS classification were associated with malignancy (P<0.05 for all variables). The 263 masses evaluated were classified as GI-RADS 2 (functional cyst; n=65), GI-RADS 3 (benign neoplasm; n=68), GI-RADS 4 (one or two morphological findings suggestive of malignancy; n=101), and GI-RADS 5 (≥3 morphological findings suggestive of malignancy; n=28). Four malignant cases with false-negative findings were misclassified as GI-RADS 3, whereas 24 benign cases with false-positive findings were misclassified as GI-RADS 4. The sensitivity, specificity, false-positive rate, false-negative rate, accuracy, and Youden index of the GI-RADS classification were 96.4%, 84.3%, 18.5%, 3.0%, 89.3%, and 80.7%, respectively.
  
  
  CONCLUSIONS
  The GI-RADS classification performed well in the diagnosis of malignant adnexal masses.
authors.affiliation: Department of Ultrasound, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|National Clinical Research Center for Cancer, Tianjin, China.|Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.|Tianjin's Clinical Research Center for Cancer, Tianjin, China.
authors.forename: Tan
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Cancer Prevention Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|National Clinical Research Center for Cancer, Tianjin, China.|Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.|Tianjin's Clinical Research Center for Cancer, Tianjin, China.
authors.forename: Fangxuan
authors.initials: F
authors.lastname: Li
authors.affiliation: Cancer Prevention Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|National Clinical Research Center for Cancer, Tianjin, China.|Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.|Tianjin's Clinical Research Center for Cancer, Tianjin, China.
authors.forename: Juntian
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Ultrasound, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|National Clinical Research Center for Cancer, Tianjin, China.|Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.|Tianjin's Clinical Research Center for Cancer, Tianjin, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000291:Adnexal Diseases / Q000145:classification* / Q000000981:diagnostic imaging* / Q000473:pathology; D000328:Adult; D000368:Aged; D005184:Fallopian Tube Diseases / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010048:Ovarian Cysts / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology; D010051:Ovarian Neoplasms / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology; D011873:Radiology Information Systems / Q000145:classification*; D012189:Retrospective Studies; D014463:Ultrasonography; D055815:Young Adult
keywords: Adnexal masses; Gynecology Imaging Reporting and Data System; Imaging diagnosis; Malignancy; Ovarian carcinoma; Ultrasonography