title: 18F-FDG PET/CT as predictor of tumour biology and prognosis in epithelial ovarian carcinoma.
abstract: OBJECTIVE
  To investigate the relationship between maximum standardised uptake value (SUVmax) of ovarian lesions and histopathology subtypes, and their involvement in the response and prognosis of patients with epithelial ovarian carcinoma (EOC).
  
  
  METHODS
  A retrospective analysis of 31 patients with EOC and18F-FDG-PET/CT before treatment, including an assessment of the SUVmax of ovarian lesion. Histopathological diagnosis and follow-up was performed. A study was made on the relationship between the SUVmax and histological type (type I and II) and tumour stage, as well as the role of various parameters (SUVmax, histology, stage) on the patient outcomes (complete response [CR], overall survival [OS], disease-free survival [DFS], and disease-free [DF] status, at 12 and 24 months).
  
  
  RESULTS
  The medium SUVmax in type I lesions was lower than in type II (6.3 and 9.3, respectively; P=.03). A 7.1 cut-off was set for SUVmax in order to identify type II EOC (sensitivity: 77.8%, specificity: 69.2%; AUC=0.748; P=.02). No significant relationship was found between tumour stage and SUVmax. CR was more common in early stages; relative risk (RR) of 1.64; P=.003, as well as in type I tumours and a lower SUVmax. Tumour stage was decisive in DFS (P=.04), LE24m (0.07) and OS (P=.08). Longer DFS and a higher percentage of DF 24m were observed in type I tumours (RR: 1.32; P=.26).
  
  
  CONCLUSIONS
  SUVmax was related to EOC histology, so could predict the response and prognosis of these patients. No association was found between glycolytic activity of the primary tumor with the response and prognosis.
authors.affiliation: Hospital General Universitario Ciudad Real, Ciudad Real, España. Electronic address: bgg-ist@hotmail.com.
authors.forename: B
authors.initials: B
authors.lastname: González García
authors.affiliation: Hospital General Universitario Ciudad Real, Ciudad Real, España.
authors.forename: A M
authors.initials: AM
authors.lastname: García Vicente
authors.affiliation: Hospital General Universitario Ciudad Real, Ciudad Real, España.
authors.forename: G A
authors.initials: GA
authors.lastname: Jiménez Londoño
authors.affiliation: Hospital General Universitario Ciudad Real, Ciudad Real, España.
authors.forename: F J
authors.initials: FJ
authors.lastname: Pena Pardo
authors.affiliation: Hospital General Universitario Ciudad Real, Ciudad Real, España.
authors.forename: M E
authors.initials: ME
authors.lastname: Bellón Guardia
authors.affiliation: Hospital General Universitario Ciudad Real, Ciudad Real, España.
authors.forename: M P
authors.initials: MP
authors.lastname: Talavera Rubio
authors.affiliation: Hospital General Universitario Ciudad Real, Ciudad Real, España.
authors.forename: A
authors.initials: A
authors.lastname: Palomar Muñoz
authors.affiliation: Hospital General Universitario Ciudad Real, Ciudad Real, España.
authors.forename: P
authors.initials: P
authors.lastname: Gómez Herrero
authors.affiliation: Hospital General Universitario Ciudad Real, Ciudad Real, España.
authors.forename: Á M
authors.initials: ÁM
authors.lastname: Soriano Castrejón
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000077216:Carcinoma, Ovarian Epithelial; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D008954:Models, Biological; D020360:Neoadjuvant Therapy; D009375:Neoplasms, Glandular and Epithelial / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology / Q000628:therapy; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology / Q000628:therapy; D010052:Ovariectomy; D000072078:Positron Emission Tomography Computed Tomography; D011379:Prognosis; D019275:Radiopharmaceuticals; D012189:Retrospective Studies
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)F-FDG-PET/CT; (18)F-FDG-PET/TC; Cáncer epitelial de ovario; Epithelial ovarian carcinoma; Prognosis; Pronóstico; Response; Respuesta al tratamiento