title: The significance of the levels of IL-4, IL-31 and TLSP in patients with asthma and/or rhinitis.
abstract: To investigate the clinical significance of the levels of IL-4, IL-33 and thymic stromal lymphopoietin (TLSP) in patients with asthma and/or rhinitis, then do the simple verification in animals.
  
  
  
  Levels of IL-4 IL-31, IL-33 and TLSP were detected by ELISA and real-time PCR in 64 asthma patients (sIgE[+]: 32 cases, sIgE[-]: 32 cases), 64 rhinitis patients (sIgE[+]: 32 cases, sIgE[-]: 32 cases), 64 asthma complicated with allergic rhinitis patients (sIgE[+]: 32 cases, sIgE[-]: 32 cases) and 32 healthy controls. Then we detected the IL-4, IL-31, IL-33 and TLSP in the sensitized mice.
  
  
  
  Results showed that levels of IL-4, IL-31, IL-33 and TSLP in asthma and rhinitis patients, and those complicated with allergic rhinitis, had significant differences compared with the control group (p < 0.05). It was found that the indicators of mugwort and dust mite allergic patients were significantly higher than that of other allergic patients (p < 0.05). We got the same tendency in in vivo experiments.
  
  
  
  IL-4, IL-31, IL-33 and TSLP may be involved in the pathogenesis of asthma and rhinitis; dust mite and mugwort allergy could increase them significantly.
authors.affiliation: Department of immunology, China Medical University, Shenyang 110010, China.
authors.forename: Ruonan
authors.initials: R
authors.lastname: Chai
authors.affiliation: Department of immunology, China Medical University, Shenyang 110010, China.
authors.forename: Beixing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of immunology, China Medical University, Shenyang 110010, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Qi
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology; D052179:Antigens, Plant / Q000276:immunology; D019306:Artemisia / Q000276:immunology; D001249:Asthma / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D001798:Blood Proteins / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D002648:Child; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D000067596:Interleukin-33 / Q000235:genetics / Q000378:metabolism*; D015847:Interleukin-4 / Q000235:genetics / Q000378:metabolism*; D007378:Interleukins / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008875:Middle Aged; D008925:Mites / Q000276:immunology; D065631:Rhinitis, Allergic / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D055815:Young Adult; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D039741:Antigens, Dermatophagoides; D052179:Antigens, Plant; D001798:Blood Proteins; D016207:Cytokines; C502187:IL31 protein, human; D000067596:Interleukin-33; D007378:Interleukins; D015847:Interleukin-4; D007073:Immunoglobulin E; D000094632:Thymic Stromal Lymphopoietin
keywords: asthma; dust mite; mugwort; rhinitis