title: Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort.
abstract: Vitamin D binding protein (DBP) gene encodes for Gc, an α2globulin that transports vitamin D metabolites in serum. Given the role of vitamin D in MS onset and disease progression we analyzed the frequencies of three polymorphisms (rs7041, rs4588 and rs2282679) within DBP gene in 701 Italian multiple sclerosis (MS) patients and 831 healthy controls (HC). None of the polymorphisms showed any association with MS onset and progression. Our results suggest that DBP is not involved in the pathogenesis of MS in Italians.
authors.affiliation: Don C. Gnocchi Foundation, IRCCS, Piazza Morandi, 3, 20121 Milano, Italy. Electronic address: cagliardi@dongnocchi.it.
authors.forename: Cristina
authors.initials: C
authors.lastname: Agliardi
authors.affiliation: Don C. Gnocchi Foundation, IRCCS, Piazza Morandi, 3, 20121 Milano, Italy.
authors.forename: Franca Rosa
authors.initials: FR
authors.lastname: Guerini
authors.affiliation: Don C. Gnocchi Foundation, IRCCS, Piazza Morandi, 3, 20121 Milano, Italy.
authors.forename: Milena
authors.initials: M
authors.lastname: Zanzottera
authors.affiliation: Don C. Gnocchi Foundation, IRCCS, Piazza Morandi, 3, 20121 Milano, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Bolognesi
authors.affiliation: Don C. Gnocchi Foundation, IRCCS, Piazza Morandi, 3, 20121 Milano, Italy.
authors.forename: Andrea Saul
authors.initials: AS
authors.lastname: Costa
authors.affiliation: Don C. Gnocchi Foundation, IRCCS, Piazza Morandi, 3, 20121 Milano, Italy; Department of Biomedical Sciences and Technology, University of Milano, Via Flli Cervi 93, 20090 Segrate, Milano, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Clerici
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D014807:Vitamin D / Q000097:blood; D014809:Vitamin D-Binding Protein / Q000235:genetics*; D055815:Young Adult
chemical_list: D014809:Vitamin D-Binding Protein; D014807:Vitamin D
keywords: DBP; Gc; Multiple sclerosis; Polymorphism; SNP; Vitamin D