title: Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy.
abstract: Existing dosimetric quantities do not fully account for the dynamic interactions between the key components of photodynamic therapy (PDT) or the varying PDT oxygen consumption rates for different fluence rates. Using a macroscopic model, reacted singlet oxygen ( [ O 2 1 ] rx ) was calculated and evaluated for its effectiveness as a dosimetric metric for PDT outcome. Mice bearing radiation-induced fibrosarcoma tumors were treated with benzoporphyrin derivative monoacid ring A (BPD) at a drug-light interval of 3 h with various in-air fluences (30 to 350 ?? J / cm 2 ) and in-air fluence rates (50 to 150 ?? mW / cm 2 ). Explicit measurements of BPD concentration and tissue optical properties were performed and used to calculate [ O 2 1 ] rx , photobleaching ratio, and PDT dose. For four mice, in situ measurements of O 2
authors.affiliation: University of Pennsylvania, Department of Radiation Oncology, Philadelphia, Pennsylvania, United StatesbUniversity of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
authors.forename: Michele M
authors.initials: MM
authors.lastname: Kim
authors.affiliation: University of Pennsylvania, Department of Radiation Oncology, Philadelphia, Pennsylvania, United States.
authors.forename: Rozhin
authors.initials: R
authors.lastname: Penjweini
authors.affiliation: University of Pennsylvania, Department of Radiation Oncology, Philadelphia, Pennsylvania, United States.
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Zhu
mesh_terms: D000818:Animals; D005354:Fibrosarcoma / Q000628:therapy*; D051379:Mice; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000494:pharmacology; D011166:Porphyrins / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000032:analysis*; D016896:Treatment Outcome; D000077362:Verteporfin
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin; D026082:Singlet Oxygen