title: Soluble CD40 ligand contributes to blood-brain barrier breakdown and central nervous system inflammation in multiple sclerosis and neuromyelitis optica spectrum disorder.
abstract: Soluble CD40 ligand (sCD40L) is reported to disrupt the blood-brain barrier (BBB). Cerebrospinal fluid (CSF) and serum sCD40L levels were measured in 29 multiple sclerosis (MS), 29 neuromyelitis optica spectrum disorder (NMOSD), and 27 disease control (DC) patients. In MS, serum sCD40L levels were higher than in DCs and positively correlated with the CSF/serum albumin ratio (Qalb). In NMOSD, CSF sCD40L levels were significantly increased compared to DCs, and were correlated to Qalb, CSF cell counts, protein concentrations, and interleukin-6 levels. sCD40L could be involved in BBB disruption in MS, whereas it may contribute to CNS inflammation in NMOSD.
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Japan. Electronic address: hiroki_masuda@msn.com.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Masuda
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Japan. Electronic address: morim@faculty.chiba-u.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mori
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Japan. Electronic address: n9n13@hotmail.com.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Japan. Electronic address: auzawa@chiba-u.jp.
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Uzawa
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Japan. Electronic address: ryohei_otani@yahoo.co.jp.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Ohtani
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Japan. Electronic address: kuwabara-s@faculty.chiba-u.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
mesh_terms: D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier / Q000503:physiopathology*; D023201:CD40 Ligand / Q000097:blood* / Q000134:cerebrospinal fluid*; D002490:Central Nervous System / Q000473:pathology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000473:pathology*; D009471:Neuromyelitis Optica / Q000097:blood / Q000134:cerebrospinal fluid / Q000473:pathology*; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D015850:Interleukin-6; D023201:CD40 Ligand
keywords: Blood-brain barrier; CD40 ligand; Central nervous system; Cerebrospinal fluid; Multiple sclerosis; Neuromyelitis optica