title: Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor.
abstract: Thermosensitive yolk-shell nanoparticles were developed as remote-controlled targeting drug delivery platform for multimodal imaging and combined therapy of cancer. The nanoparticles were fabricated using magnetic Fe3O4nanoparticles as photothermal cores, thermo-responsive poly(N-isopropylacrylamide)-co-1-Vinyl-2-pyrrolidone p(NIPAM-co-NVP) as shells (Fe3O4-PNIPAM), with a hollow space between the two layers for loading of chemotherapeutic drug. The magnetic iron oxide nanoparticle cores could absorb and transform light to heat efficiently upon the irradiation of near infrared (NIR) laser, resulting in the shrink of the PNIPAM shell and the release of chemo-drugs. In vivo fluorescence/photoacoustic images demonstrated that Fe3O4-PNIPAM nanoparticles could accumulate in the tumor after intravenous injection. Upon the irradiation of the NIR laser, DOX-Fe3O4-PNIPAM nanoparticles exhibited outstanding synergistic effect. The tumor inhibition rate increased from 40.3% (DOX-Fe3O4-PNIPAM alone) and 65.2% (Fe3O4-PNIPAM +NIR) to 91.5%. The results demonstrated that the NIR-responsive nanocarrier offers a novel strategy for cancer theranostics and combined therapy of cancer.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang, China.
authors.forename: Song
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Ding
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang, China.
authors.forename: Shengchang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang, China. Electronic address: qixyemail@163.com.
authors.forename: Xueyong
authors.initials: X
authors.lastname: Qi
authors.affiliation: Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.affiliation: Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.affiliation: Institute of Green Chemistry and Chemical Technology, Jiangsu University, Zhenjiang, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang, China. Electronic address: geyanru@ujs.edu.cn.
authors.forename: Yanru
authors.initials: Y
authors.lastname: Ge
authors.affiliation: Department of Clinical Pharmacy, Affiliated Hospital of Jiangsu University, Zhenjiang, China. Electronic address: linmeimei1983@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Wu
mesh_terms: D000818:Animals; D001943:Breast Neoplasms; D016503:Drug Delivery Systems; D006801:Humans; D007259:Infrared Rays; D051379:Mice; D064847:Multimodal Imaging; D053758:Nanoparticles; D009369:Neoplasms; D014407:Tumor Cells, Cultured
keywords: Magnetic iron oxide; Photoacoustic imaging; Photothermal therapy; Targeting drug delivery; Thermoresponsive