title: Analyzing the efficacy of frequent sodium checks during hypertonic saline infusion after elective brain tumor surgery.
abstract: OBJECTIVE
  To assess the utility of frequent sodium checks (every 6h) in patients receiving hypertonic saline (HS) after elective brain tumor surgeries.
  
  
  METHODS
  A single-institution retrospective review of patients having undergone elective craniotomies for brain tumors and treated with postoperative continuous intravenous infusions of 3% HS was performed. Changes in serum sodium values were analyzed at different time points. The rates of <12.5, 25, and 50cc/h infusions were also examined. Healthcare cost analysis was performed by extrapolating our cohort to the total number of craniotomies performed in the United States.
  
  
  RESULTS
  No significant differences among sodium values checked between 0 to 4, 4-6, 6-8, 8-10, and >10h were observed (P=.64). In addition, no differences in serum sodium values among the rates of <12.5, 25, and 50cc/h were found (P=.30). No patients developed symptoms of acute hypernatremia.
  
  
  CONCLUSIONS
  Serum sodium values did not significantly change more than 10h after infusion of HS. Further studies are needed to determine the optimal frequency of routine sodium checks to increase the quality of care and decrease healthcare costs.
authors.affiliation: Departments of Neurosurgery, Los Angeles, United States.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Tucker
authors.affiliation: Departments of Neurosurgery, Los Angeles, United States.
authors.forename: Seung J
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Departments of Neurosurgery, Los Angeles, United States.
authors.forename: Lawrance K
authors.initials: LK
authors.lastname: Chung
authors.affiliation: Departments of Neurosurgery, Los Angeles, United States.
authors.forename: Natalie E
authors.initials: NE
authors.lastname: Barnette
authors.affiliation: Departments of Neurosurgery, Los Angeles, United States.
authors.forename: Brittany L
authors.initials: BL
authors.lastname: Voth
authors.affiliation: Departments of Neurosurgery, Los Angeles, United States.
authors.forename: Carlito
authors.initials: C
authors.lastname: Lagman
authors.affiliation: Departments of Neurosurgery, Los Angeles, United States.
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Nagasawa
authors.affiliation: Departments of Neurosurgery, Los Angeles, United States; Radiation Oncology, Los Angeles, United States; Head and Neck Surgery, Los Angeles, United States; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, United States. Electronic address: iyang@mednet.ucla.edu.
authors.forename: Isaac
authors.initials: I
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000601:surgery*; D003363:Cost Control; D003711:Demyelinating Diseases / Q000209:etiology; D017558:Elective Surgical Procedures; D005260:Female; D006403:Hematologic Tests / Q000191:economics / Q000706:statistics & numerical data*; D006801:Humans; D006955:Hypernatremia / Q000097:blood / Q000453:epidemiology; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D011184:Postoperative Period; D012189:Retrospective Studies; D012462:Saline Solution, Hypertonic / Q000493:pharmacokinetics*; D012964:Sodium / Q000097:blood*; D055815:Young Adult
chemical_list: D012462:Saline Solution, Hypertonic; D012964:Sodium