title: Idiopathic Intracranial Hypertension in Monozygotic Female Twins: Intracranial Pressure Dynamics and Treatment Outcome.
abstract: BACKGROUND
  Familial cases of idiopathic intracranial hypertension (IIH) are exceedingly rare, and its occurrence in monozygotic twins has not been reported previously.
  
  
  METHODS
  We report monozygotic female twins who developed IIH, one at age 25 years and the other at age 28 years. Continuous intracranial pressure (ICP) monitoring confirmed elevated ICP as measured initially by lumbar puncture. In both cases, successful treatment with resolution of papilledema and symptoms relief was achieved after ventriculoperitoneal shunting.
  
  
  CONCLUSIONS
  This report documents the first case of IIH in monozygotic twins and the associated changes in ICP dynamics. Interestingly, almost equivalent alterations in ICP dynamics were found in the 2 patients.
authors.affiliation: Department of Neurosurgery, Hannover Medical School, Hannover, Germany. Electronic address: polemikos_manolis@hotmail.com.
authors.forename: Manolis
authors.initials: M
authors.lastname: Polemikos
authors.affiliation: Department of Neurosurgery, Hannover Medical School, Hannover, Germany.
authors.forename: Hans E
authors.initials: HE
authors.lastname: Heissler
authors.affiliation: Department of Neurosurgery, Hannover Medical School, Hannover, Germany.
authors.forename: Elvis J
authors.initials: EJ
authors.lastname: Hermann
authors.affiliation: Department of Neurosurgery, Hannover Medical School, Hannover, Germany.
authors.forename: Joachim K
authors.initials: JK
authors.lastname: Krauss
mesh_terms: D000328:Adult; D004200:Diseases in Twins / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000000981:diagnostic imaging* / Q000601:surgery*; D007427:Intracranial Pressure / Q000502:physiology*; D016896:Treatment Outcome; D014430:Twins, Monozygotic / Q000235:genetics*; D017287:Ventriculoperitoneal Shunt / Q000379:methods*
keywords: Familial; Idiopathic intracranial hypertension; Intracranial pressure; Monozygotic twins; Pseudotumor cerebri