title: Successful Treatment of Generalized Essential Telangiectasia With 6-Mercaptopurine.
abstract: <p>Generalized essential telangiectasia (GET) is a notoriously difficult to treat disorder with no current satisfactory treatments. This case and discussion report the use of 6-mercaptopurine (6-MP) as a successful treatment for GET. Moreover, we show that GET may represent a state of increased angiogenesis, a paradigm shift from the current understanding that these telangiectasias represent dilatations of only pre-existing vessels. This new view of GET may drive others to look at novel agents for treatment.</p> <p><em>J Drugs Dermatol. 2017;16(3):280-282.</em></p>.
authors.forename: Alex M
authors.initials: AM
authors.lastname: Glazer
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Sofen
authors.forename: Darrell S
authors.initials: DS
authors.lastname: Rigel
authors.forename: Jerome L
authors.initials: JL
authors.lastname: Shupack
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D015415:Biomarkers / Q000652:urine; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D024141:Collagen Type IV / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000652:urine; D006801:Humans; D054025:Lasers, Dye / Q000627:therapeutic use; D028022:Low-Level Light Therapy; D015122:Mercaptopurine / Q000008:administration & dosage / Q000627:therapeutic use*; D045726:Metalloproteases / Q000652:urine; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000652:urine*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D013684:Telangiectasis / Q000188:drug therapy* / Q000473:pathology / Q000523:psychology / Q000532:radiotherapy
chemical_list: D018952:Antigens, CD34; D000964:Antimetabolites, Antineoplastic; D015415:Biomarkers; D024141:Collagen Type IV; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D005340:Fibrinogen; D015122:Mercaptopurine; D045726:Metalloproteases