title: The Role of Runx1 in Embryonic Blood Cell Formation.
abstract: The de novo generation of hematopoietic stem and progenitor cells (HSPC) occurs solely during embryogenesis from a population of epithelial cells called hemogenic endothelium (HE). During midgestation HE cells in multiple intra- and extraembryonic vascular beds leave the vessel wall as they transition into HSPCs in a process termed the endothelial to hematopoietic transition (EHT). Runx1 expression in HE cells orchestrates the transcriptional switch necessary for the transdifferentiation of endothelial cells into functional HSPCs. Runx1 is widely considered the master regulator of developmental hematopoiesis because it plays an essential function during specification of the hematopoietic lineage during embryogenesis. Here we review the role of Runx1 in embryonic HSPC formation, with a particular focus on its role in hemogenic endothelium.
authors.affiliation: Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19103, USA.
authors.forename: Amanda D
authors.initials: AD
authors.lastname: Yzaguirre
authors.affiliation: MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford, OX3 9DS, UK.
authors.forename: Marella F T R
authors.initials: MF
authors.lastname: de Bruijn
authors.affiliation: Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19103, USA. nancyas@exchange.upenn.edu.
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Speck
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000378:metabolism*; D054338:Cell Transdifferentiation / Q000502:physiology; D050676:Core Binding Factor Alpha 2 Subunit / Q000378:metabolism*; D047108:Embryonic Development / Q000502:physiology*; D053595:Embryonic Stem Cells / Q000378:metabolism / Q000502:physiology; D004730:Endothelium, Vascular / Q000378:metabolism; D055018:Hemangioblasts / Q000378:metabolism*; D006410:Hematopoiesis / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D013234:Stem Cells / Q000378:metabolism
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit
keywords: Hematopoiesis; Hematopoietic stem cell; Hemogenic endothelium; Runx1