title: Pore modulation of zirconium-organic frameworks for high-efficiency detection of trace proteins.
abstract: Tunable electrochemical biosensors based on analogous Zr-MOFs were developed for protein detection, the performances of which rely on the pore sizes and surroundings of the MOFs that show diverse binding behaviors to aptamers and then the targeted proteins. The optimized Zr-MOF-based sensor has high selectivity to lysozyme in a wide concentration range and a low detection limit of 3.6 pg mL-1, with good repeatability, stability, and applicability in real samples. This work will establish a new platform for biosensing and extend the application scope of MOF materials.
authors.affiliation: Henan Provincial Key Lab of Surface & Interface Science, Zhengzhou University of Light Industry, Zhengzhou 450002, P. R. China. dumiao@zzuli.edu.cn.
authors.forename: Chun-Sen
authors.identifier: http://orcid.org/0000-0002-5095-7359
authors.initials: CS
authors.lastname: Liu
authors.affiliation: Henan Provincial Key Lab of Surface & Interface Science, Zhengzhou University of Light Industry, Zhengzhou 450002, P. R. China. dumiao@zzuli.edu.cn.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Zhang
authors.affiliation: Henan Provincial Key Lab of Surface & Interface Science, Zhengzhou University of Light Industry, Zhengzhou 450002, P. R. China. dumiao@zzuli.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Henan Provincial Key Lab of Surface & Interface Science, Zhengzhou University of Light Industry, Zhengzhou 450002, P. R. China. dumiao@zzuli.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Henan Provincial Key Lab of Surface & Interface Science, Zhengzhou University of Light Industry, Zhengzhou 450002, P. R. China. dumiao@zzuli.edu.cn.
authors.forename: Feng-He
authors.initials: FH
authors.lastname: Duan
authors.affiliation: Henan Provincial Key Lab of Surface & Interface Science, Zhengzhou University of Light Industry, Zhengzhou 450002, P. R. China. dumiao@zzuli.edu.cn.
authors.forename: Di-Ming
authors.initials: DM
authors.lastname: Chen
authors.affiliation: Henan Provincial Key Lab of Surface & Interface Science, Zhengzhou University of Light Industry, Zhengzhou 450002, P. R. China. dumiao@zzuli.edu.cn.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Wang
authors.affiliation: Henan Provincial Key Lab of Surface & Interface Science, Zhengzhou University of Light Industry, Zhengzhou 450002, P. R. China. dumiao@zzuli.edu.cn.
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Henan Provincial Key Lab of Surface & Interface Science, Zhengzhou University of Light Industry, Zhengzhou 450002, P. R. China. dumiao@zzuli.edu.cn.
authors.forename: Miao
authors.identifier: http://orcid.org/0000-0002-1029-1820
authors.initials: M
authors.lastname: Du
mesh_terms: D015374:Biosensing Techniques; D055664:Electrochemical Techniques; D008958:Models, Molecular; D009113:Muramidase / Q000032:analysis* / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry*; D010316:Particle Size; D015040:Zirconium / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D015040:Zirconium; D009113:Muramidase