title: Nerve cell production in Hydra is deregulated by tumour-promoting phorbol ester.
abstract: The tumour-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) interfers with nerve cell production in Hydra when applied to the animals' culture medium. Precursor cells exposed to 0.2 nM TPA during the first half of their S-phase are prevented from differentiating into nerve cells. Precursor cells which start their S-phase following a treatment with TPA give rise to nerve cells. The frequency is higher than in untreated control animals.
authors.affiliation: Zoologisches Institut der Universität zu Köln, Weyertal 119, W-5000, Köln, Federal Republic of Germany.
authors.forename: Valerie
authors.initials: V
authors.lastname: Greger
authors.affiliation: Zoologisches Institut der Universität zu Köln, Weyertal 119, W-5000, Köln, Federal Republic of Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Berking
keywords: Differentiation; Hydra; Nerve cells; Tumour-promoting phorbol esters