title: Near-Infrared Spectroscopy Reveals Abnormal Hemodynamics in the Left Dorsolateral Prefrontal Cortex of Menopausal Depression Patients.
abstract: Background/Objective. Menopausal depression (MD) is characterized by depressive symptoms along with hormonal fluctuations. We investigate brain function alteration between major depressive disorder (MDD) and MD.Methods. The difference in oxygenated hemoglobin (Oxy-Hb) for the prefrontal cortex (PFC) was compared retrospectively among 90 females presented with 30 MDD, 30 MD, and 30 healthy controls (HCs) using verbal fluency task (VFT) with near-infrared spectroscopy (NIRS).Results. We observed a significant difference in Oxy-Hb alteration in the left dorsolateral PFC (DLPFC) using VFT with NIRS (channel 18,P= 0.007) between the MD and MDD groups. A significant difference in Oxy-Hb levels was observed among the three groups in the bilateral DLPFC (channels 18, 27, 33, 39, 41, and 45;P< 0.05). Compared to the HCs, the MD group presented lower Oxy-Hb activation in the right DLPFC (channel 41;P= 0.048) and the left DLPFC (channels 18, 39, and 45;P< 0.05), and the MDD group presented lower Oxy-Hb activation in the right DLPFC (channels 27, 33, and 41;P< 0.05) and the left DLPFC (channels 39 and 45;P< 0.05).Conclusion. Abnormal hemodynamics of the left DLPFC can differentiate MD from MDD by NIRS.
authors.affiliation: Medical Center, Tsinghua University, Beijing, China; YuQuan Hospital, Tsinghua University, Beijing, China.
authors.forename: Xiang-Yun
authors.identifier: 0000-0002-7925-6791
authors.initials: XY
authors.lastname: Ma
authors.affiliation: Tianjin Anding Hospital, Tianjin, China.
authors.forename: Yong-Jun
authors.identifier: 0000-0001-9643-6615
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: YuQuan Hospital, Tsinghua University, Beijing, China.
authors.forename: Bo
authors.identifier: 0000-0002-8389-338X
authors.initials: B
authors.lastname: Xu
authors.affiliation: YuQuan Hospital, Tsinghua University, Beijing, China.
authors.forename: Kun
authors.identifier: 0000-0001-6762-596X
authors.initials: K
authors.lastname: Feng
authors.affiliation: YuQuan Hospital, Tsinghua University, Beijing, China.
authors.forename: Gao-Xiang
authors.identifier: 0000-0001-9754-1484
authors.initials: GX
authors.lastname: Sun
authors.affiliation: YuQuan Hospital, Tsinghua University, Beijing, China.
authors.forename: Xiao-Qian
authors.identifier: 0000-0002-3830-3651
authors.initials: XQ
authors.lastname: Zhang
authors.affiliation: YuQuan Hospital, Tsinghua University, Beijing, China.
authors.forename: Xiao-Min
authors.identifier: 0000-0002-0920-4195
authors.initials: XM
authors.lastname: Liu
authors.affiliation: YuQuan Hospital, Tsinghua University, Beijing, China.
authors.forename: Chen-Yu
authors.initials: CY
authors.lastname: Shen
authors.affiliation: Medical Center, Tsinghua University, Beijing, China; YuQuan Hospital, Tsinghua University, Beijing, China.
authors.forename: Xia-Jin
authors.identifier: 0000-0003-3083-4236
authors.initials: XJ
authors.lastname: Ren
authors.affiliation: Medical Center, Tsinghua University, Beijing, China; YuQuan Hospital, Tsinghua University, Beijing, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Sun
authors.affiliation: YuQuan Hospital, Tsinghua University, Beijing, China.
authors.forename: Po-Zi
authors.identifier: 0000-0002-6637-3999
authors.initials: PZ
authors.lastname: Liu
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000503:physiopathology*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*