title: [Stable Nitric Oxide Metabolites Levels in Hypertensive Patients With Obesity and High Leptin Level].
abstract: to investigate levels of the stable nitric oxide metabolites (NOx) in hypertensive patients with obesity and hyperleptinemia.
  
  
  
  We examined 124 untreated patients (45 men and 79 women) with essential hypertension (EH) (mean age 51.4+/-6.5 years, mean hypertension duration 8.5+/-7.6 years, 64% with visceral obesity) and 25 healthy volunteers (10 men and 15 women with comparable age).
  
  
  
  NOx levels were significantly higher in hypertensives (43.18+/-21 mol/l) then in controls (28.3+/-9.6 mol/l; p=0.01). Obese hypertensives had lower NOx concentration than nonobese hypertensives (38.8+/-17.9 and 48.5+/-24.7 mol/l, respectively; <0.05). With increase of degree of obesity NOx levels decreased significantly (r=-0.3; p<0.05). NOx levels correlated with presence (r=-0.44; p<0,05) and degree of obesity (r=-0.3; p<0.05). Hypertensives with high leptin levels had lower NOx concentration (29+/-12.2 mol/l), compared to hypertensives with normal leptin levels (34. 7+/-10.5 mol/l) (p<0.05).
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Podzolkov
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Bragina
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: N F
authors.initials: NF
authors.lastname: Murashko
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000201:enzymology*; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000150:complications / Q000201:enzymology*
chemical_list: D020738:Leptin; D009569:Nitric Oxide
keywords: arterial hypertension; leptin; nitric oxide; obesity