title: [Effect of Combined Antihypertensive Therapy With Perindopril and Indapamide on Morpho-Functional Parameters of The Heart, Blood Vessels of Small and Medium Caliber in Patients With Essential Hypertension].
abstract: OBJECTIVE
  to study effect of therapy with fixed combination of angiotensin-converting enzyme infibitor and diuretic on structural-functional parameters of the heart and vessels and cognitive function.
  
  
  METHODS
  We included into this study 30 patients (20 women) with mean age 60.06+/-10.19 years, duration of hypertensive disease 14.7 (3; 32) years, body mass index 31.19+/-3.93 kg/m2, and without history of cerebrovascular diseases. Methods of investigation included clinical examination, measurement of parameters of hemodynamics, electro- and echocardiography. Vascular endothelial function and structural - functional state of finger skin capillary network was studied by photopletismography and video capillaroscopy, respectively. The state of cognitive sphere was evaluated with the help of the Montreal Cognitive Assessment (MoCA) test.
  
  
  RESULTS
  We noted improvement of endothelial function of middle caliber arteries and microcirculatory vascular bed (MCVB) (increase of occlusion index at the level of MCVB from 1.4 to 1.8, p<0.00005; increase of density of skin capillary network at rest from 45 to 52 kap/2, p<0.00007); improvement of cognitive function according to changes of MoCA test results (from 23 to 27, p<0,0001). There were no changes of lipid and carbohydrate metabolism, and electrolyte balance. Conclision. The use of fixed of perindopril+indopamide is combination characterized by good tolerability and high results.
authors.affiliation: 1Sechenov First Moscow State Medical University, Moscow, Russia; 2Research Center of Neurology, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Zheleznyh
authors.affiliation: 1Sechenov First Moscow State Medical University, Moscow, Russia; 2Research Center of Neurology, Moscow, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Danilogorskaya
authors.affiliation: 1Sechenov First Moscow State Medical University, Moscow, Russia; 2Research Center of Neurology, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Privalova
authors.affiliation: 1Sechenov First Moscow State Medical University, Moscow, Russia; 2Research Center of Neurology, Moscow, Russia.
authors.forename: Yu N
authors.initials: YN
authors.lastname: Belenkov
authors.affiliation: 1Sechenov First Moscow State Medical University, Moscow, Russia; 2Research Center of Neurology, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Schendrygina
authors.affiliation: 1Sechenov First Moscow State Medical University, Moscow, Russia; 2Research Center of Neurology, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Pavlov
authors.affiliation: 1Sechenov First Moscow State Medical University, Moscow, Russia; 2Research Center of Neurology, Moscow, Russia.
authors.forename: M I
authors.initials: MI
authors.lastname: Tishman
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004452:Echocardiography; D000075222:Essential Hypertension / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007190:Indapamide / Q000627:therapeutic use*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D020913:Perindopril / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D007190:Indapamide; D020913:Perindopril