title: [Gastric adenoma of pyloric type associated with familial adenomatous polyposis: A rare histological type not to be overlooked].
abstract: We report here two cases of gastric adenomas of pyloric type diagnosed during the follow-up of familial adenomatous polyposis (FAP). This rare histological lesion has been only recently described in this particular context and its clinical and pathological spectrum remains to be evaluated. Our two cases were very different in their clinical and endoscopic presentation. In the first patient, the lesion was diagnosed late during the evolution of FAP; it was very large and protruded above the adjacent mucosa; because of its large size, its treatment proved to be difficult. In the second patient, the lesion was discovered incidentally in gastric biopsies, early in the course of FAP. Both lesions presented the characteristic morphological and immunohistochemical features of pyloric adenoma, including the expression of MUC6. Both showed evidence of dysplasia, including high-grade dysplasia in the largest lesion. Pyloric adenoma belongs to the spectrum of gastric polyps associated with FAP; its prognosis and evolution remain to be evaluated.
authors.affiliation: Service de pathologie morphologique, département de biologie et pathologie médicales, Gustave-Roussy Cancer Campus Grand Paris, 114, rue Edouard-Vaillant, 94805 Villejuif cedex, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Didier
authors.affiliation: Service de pathologie morphologique, département de biologie et pathologie médicales, Gustave-Roussy Cancer Campus Grand Paris, 114, rue Edouard-Vaillant, 94805 Villejuif cedex, France.
authors.forename: Peggy
authors.initials: P
authors.lastname: Dartigues
authors.affiliation: Service de pathologie morphologique, département de biologie et pathologie médicales, Gustave-Roussy Cancer Campus Grand Paris, 114, rue Edouard-Vaillant, 94805 Villejuif cedex, France.
authors.forename: Ranya
authors.initials: R
authors.lastname: Soufan
authors.affiliation: Service de gastroentérologie, département de médecine, Gustave-Roussy Cancer Campus Grand Paris, 114, rue Edouard-Vaillant, 94805 Villejuif cedex, France.
authors.forename: David
authors.initials: D
authors.lastname: Malka
authors.affiliation: Service de gastroentérologie, département de médecine, Gustave-Roussy Cancer Campus Grand Paris, 114, rue Edouard-Vaillant, 94805 Villejuif cedex, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Burtin
authors.affiliation: Service de pathologie morphologique, département de biologie et pathologie médicales, Gustave-Roussy Cancer Campus Grand Paris, 114, rue Edouard-Vaillant, 94805 Villejuif cedex, France; Faculté de médecine de Bicêtre, université Paris-Sud, université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France. Electronic address: jean-yves.scoazec@gustaveroussy.fr.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Scoazec
mesh_terms: D000236:Adenoma / Q000145:classification / Q000150:complications* / Q000473:pathology*; D011125:Adenomatous Polyposis Coli / Q000150:complications*; D000293:Adolescent; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000145:classification / Q000150:complications* / Q000473:pathology*
keywords: Adénome gastrique; Adénome pylorique; Dysplasia; Dysplasie; Familial adenomatous polyposis; Gastric adenoma; MUC6; Polypose adénomateuse familiale; Pyloric adenoma