title: Duration of platelet storage and outcomes of critically ill patients.
abstract: The storage duration of platelet (PLT) units is limited to 5 to 7 days. This study investigates whether PLT storage duration is associated with patient outcomes in critically ill patients.
  
  
  
  This study was a retrospective analysis of critically ill patients admitted to the intensive care unit (ICU) of two hospitals in Australia who received one or more PLT transfusions from 2008 to 2014. Storage duration was approached in several different ways. Outcome variables were hospital mortality and ICU-acquired infection. Associations between PLT storage duration and outcomes were evaluated using multiple logistic regression and also by Cox regression.
  
  
  
  Among 2250 patients who received one or more PLT transfusions while in the ICU, the storage duration of PLTs was available for 64% of patients (1430). In-hospital mortality was 22.1% and ICU infection rate 7.2%. When comparing patients who received PLTs of a maximum storage duration of not more than 3, 4, or 5 days, there were no significant differences in baseline characteristics. After confounders were adjusted for, the storage duration of PLTs was not independently associated with mortality (4 days vs. ≤3 days, odds ratio [OR] 0.88, 95% confidence interval [CI] 0.59-1.30; 5 days vs. ≤3 days, OR 0.97, 95% CI 0.68-1.37) or infection (4 days vs. ≤3 days, OR 0.71, 95% CI 0.39-1.29; 5 days vs. ≤3 days, OR 1.11, 95% CI 0.67-1.83). Similar results were obtained regardless of how storage duration of PLTs was approached.
  
  
  
  In this large observational study in a heterogeneous ICU population, storage duration of PLTs was not associated with an increased risk of mortality or infection.
authors.affiliation: The Australian and New Zealand Intensive Care Research Centre.|Royal Australian Navy, Australian Defence Force, Canberra, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Flint
authors.affiliation: The Australian and New Zealand Intensive Care Research Centre.|The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.|The Medical Intensive Care Unit, Centre Hospitalier et Universitaire de Brest site La Cavale Blanche-Université de Bretagne Occidentale, Brest, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Aubron
authors.affiliation: The Australian and New Zealand Intensive Care Research Centre.
authors.forename: Michael
authors.initials: M
authors.lastname: Bailey
authors.affiliation: The Australian and New Zealand Intensive Care Research Centre.|The Intensive Care Unit, The Austin Hospital.
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Bellomo
authors.affiliation: The Australian and New Zealand Intensive Care Research Centre.|The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Pilcher
authors.affiliation: The Infectious Disease Department, The Alfred Hospital.
authors.forename: Allen C
authors.initials: AC
authors.lastname: Cheng
authors.affiliation: The Transfusion Service of The Austin Hospital, Melbourne, Australia.
authors.forename: Colin
authors.initials: C
authors.lastname: Hegarty
authors.affiliation: The Australian and New Zealand Intensive Care Research Centre.|Joint Health Command, Australian Defence Force, Canberra, Australia.|Burns Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Australia.
authors.forename: Michael C
authors.identifier: 0000-0003-1570-0707
authors.initials: MC
authors.lastname: Reade
authors.affiliation: The Australian and New Zealand Intensive Care Research Centre.|The Transfusion Research Unit, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
authors.forename: Zoe
authors.initials: Z
authors.lastname: McQuilten
mesh_terms: D000328:Adult; D000368:Aged; D001315:Australia / Q000453:epidemiology; D001792:Blood Platelets; D001793:Blood Preservation; D016638:Critical Illness; D017052:Hospital Mortality; D006801:Humans; D007239:Infections / Q000209:etiology / Q000401:mortality; D007362:Intensive Care Units; D008875:Middle Aged; D017713:Platelet Transfusion; D012307:Risk Factors; D013997:Time Factors