title: The Heart and Great Vessels.
abstract: Cardiovascular disease is the leading cause of mortality worldwide. We have made large strides over the past few decades in management, but definitive therapeutic options to address this health-care burden are still limited. Given the ever-increasing need, much effort has been spent creating engineered tissue to replaced diseased tissue. This article gives a general overview of this work as it pertains to the development of great vessels, myocardium, and heart valves. In each area, we focus on currently studied methods, limitations, and areas for future study.
authors.affiliation: Tissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205.|College of Medicine, The Ohio State University, Columbus, Ohio 43210.
authors.forename: Ekene
authors.initials: E
authors.lastname: Onwuka
authors.affiliation: Tissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205.|College of Medicine, The Ohio State University, Columbus, Ohio 43210.
authors.forename: Nakesha
authors.initials: N
authors.lastname: King
authors.affiliation: Tissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205.
authors.forename: Eric
authors.initials: E
authors.lastname: Heuer
authors.affiliation: Tissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205.|College of Medicine, The Ohio State University, Columbus, Ohio 43210.|Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, Ohio 43205.
authors.forename: Christopher
authors.initials: C
authors.lastname: Breuer
mesh_terms: D000818:Animals; D021522:Bioartificial Organs; D001672:Biocompatible Materials; D001808:Blood Vessels / Q000166:cytology / Q000637:transplantation*; D002318:Cardiovascular Diseases / Q000628:therapy*; D006801:Humans; D009206:Myocardium / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials