title: Developmental age-related cell sorting inDictyostelium discoideum.
abstract: The sorting behavior of mixtures ofD. discoideum cells which had been developed for different lengths of time was examined. Cells developed for 4 and 8 h were mixed together and allowed to form slugs. Within the slugs, 8 h cells sorted to the anterior prestalk region while 4 h cells sorted to the posterior prespore region. These results indicate that the more developed a cell is, the more likely it is to become part of the prestalk zone in the slug. They are also consistent with the differential adhesion and chemotaxis hypotheses as a mechanism for cell sorting since cells become more adhesive and chemotactically responsive as development proceeds.
authors.affiliation: Department of Biology, Princeton University, 08544, Princeton, New Jersey, USA.
authors.forename: Sue Ann
authors.initials: SA
authors.lastname: McDonald
keywords: Adhesion; Aging; Cell differentiation; Cell sorting; Chemotaxis