title: Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation.
abstract: BACKGROUND
  Interleukin-28 (IL-28B) rs12979860 C/T polymorphism is a known predictor of sustained virological response after antiviral treatment in hepatitis C. IL-28B affects the innate immune system as well as intrahepatic expression level of interferon-stimulated genes.
  
  
  OBJECTIVE
  To investigate the effect of recipient IL-28B polymorphism on occurrence of acute rejection after liver transplantation.
  
  
  METHODS
  140 liver allograft recipients were selected. Acute rejection episodes were recorded in 39 patients (AR group); the remaining had normal graft function (non-AR group). 70 normal subjects were also studied as the control group. The IL-28B rs12979860 was genotyped through PCR-RFLP method.
  
  
  RESULTS
  No significant difference was found between AR and non-AR groups in terms of genotype and allele frequency. However, the CC genotype was significantly (p<0.001) more frequent in patients than in the control group; theCallele variants increased the risk of end-stage liver disease (OR: 2.60).
  
  
  CONCLUSIONS
  Liver damage in association with the carriage of IL-28B C allele is associated with a higher likelihood of developing cirrhosis.
authors.affiliation: Department of Physiology, Fars Science and Research Branch, Islamic Azad University, Shiraz, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Fereidooni
authors.affiliation: Transplant Research Center, Stem Cell Research Institute, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Azarpira
authors.affiliation: Transplant Research Center, Stem Cell Research Institute, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Yaghobi
authors.affiliation: Department of Physiology, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Vahdati
authors.affiliation: Transplant Research Center, Stem Cell Research Institute, Shiraz University of Medical Sciences, Shiraz, Iran ; Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: S A
authors.initials: SA
authors.lastname: Malek-Hoseini
keywords: Cirrhosis; IL-28B polymorphism; Interleukin; Liver transplantation; Rejection