title: Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort.
abstract: Casting-type calcifications and a histopathological picture with cancer-filled duct-like structures have been presented as breast cancer with neoductgenesis. We correlated mammographic features and histopathological neoductgenesis with prognosis in a DCIS cohort with long follow-up. Mammographic features were classified into seven groups according to Tabár. Histopathological neoductgenesis was defined by concentration of ducts, lymphocyte infiltration, and periductal fibrosis. Endpoints were ipsilateral (IBE) in situ and invasive events. Casting-type calcifications and neoductgenesis were both related to high nuclear grade, ER- and PR-negativity, and HER2 overexpression but not to each other. Casting-type calcifications and neoductgenesis were both related to a nonsignificant lower risk of invasive IBE, HR 0.38 (0.13-1.08) and 0.82 (0.29-2.27), respectively, and the HR of an in situ IBE was 0.90 (0.41-1.95) and 1.60 (0.75-3.39), respectively. Casting-type calcifications could not be related to a worse prognosis in DCIS. We cannot explain why a more aggressive phenotype of DCIS did not correspond to a worse prognosis. Further studies on how the progression from in situ to invasive carcinoma is driven are needed.
authors.affiliation: Department of Surgical Sciences, Uppsala University, Uppsala Academic Hospital, Uppsala, Sweden.
authors.forename: Wenjing
authors.identifier: 0000-0002-1312-6337
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Department of Pathology, Örebro University, Örebro, Sweden.
authors.forename: Thomas
authors.initials: T
authors.lastname: Sollie
authors.affiliation: Department of Pathology, Falun Central Hospital, Falun, Sweden.
authors.forename: Tibor
authors.identifier: 0000-0001-8479-0115
authors.initials: T
authors.lastname: Tot
authors.affiliation: Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Carl
authors.initials: C
authors.lastname: Blomqvist
authors.affiliation: Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden.
authors.forename: Shahin
authors.initials: S
authors.lastname: Abdsaleh
authors.affiliation: Department of Surgery, Örebro University, Örebro, Sweden.
authors.forename: Göran
authors.initials: G
authors.lastname: Liljegren
authors.affiliation: Department of Surgical Sciences, Uppsala University, Uppsala Academic Hospital, Uppsala, Sweden.
authors.forename: Fredrik
authors.identifier: 0000-0002-0130-7296
authors.initials: F
authors.lastname: Wärnberg