title: Topical interferon alpha-2B topic as the first therapeutic option in a clinical case of conjunctival intraepithelial neoplasia.
abstract: BACKGROUND
  Conjunctival intraepithelial neoplasia is a pre-malignant lesion of the ocular surface. It can be treated with topical interferon alpha-2b (INF α-2b) as first choice.
  
  
  METHODS
  A 71-year-old man referred for corneal-conjunctival, gelatinous lesion in the left eye (LE) with an area of almost 270°. The clinical diagnosis was compatible with a corneal-conjunctival intraepithelial neoplasia. Topical treatment was started with INF α-2b at a dose of one million international units (IU)/ml, 4 times/day for 4 months, with remission being achieved.
  
  
  CONCLUSIONS
  The isolated use of topical INF α-2b is an effective treatment as a first option in the case of corneal-conjunctival intraepithelial neoplasia, positioning itself as a form of effective and safe treatment compared to other therapeutic options. Surgical excision and use of other chemotherapy agents could lead to severe limbic deficits and other side effects.
authors.affiliation: Servicio Extremeño de Salud, Unidad de Córnea y Superficie Anterior, Hospital Nuestra Señora de la Montaña , Cáceres, España. Electronic address: silviapagan90@hotmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Pagán Carrasco
authors.affiliation: Servicio Extremeño de Salud, Unidad de Córnea y Superficie Anterior, Hospital Nuestra Señora de la Montaña , Cáceres, España.
authors.forename: D
authors.initials: D
authors.lastname: Arranz Maestro
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002278:Carcinoma in Situ / Q000188:drug therapy*; D003230:Conjunctival Neoplasms / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2 / Q000008:administration & dosage*; D008297:Male
chemical_list: D000970:Antineoplastic Agents; D000077190:Interferon alpha-2
keywords: Conjunctival intraepithelial neoplasia; Interferón α-2b tópico; Neoplasia intraepitelial córneo-conjuntival; Other topical adjuvant treatments; Otros tratamientos tópicos coadyuvantes; Topical interferon α-2b