title: Predictors of Outcome With Cerebral Autoregulation Monitoring: A Systematic Review and Meta-Analysis.
abstract: OBJECTIVE
  To compare cerebral autoregulation indices as predictors of patient outcome and their dependence on duration of monitoring.
  
  
  METHODS
  Systematic literature search and meta-analysis using PubMed, EMBASE, and the Cochrane Library from January 1990 to October 2015.
  
  
  METHODS
  We chose articles that assessed the association between cerebral autoregulation indices and dichotomized or continuous outcomes reported as standardized mean differences or correlation coefficients (R), respectively. Animal and validation studies were excluded.
  
  
  METHODS
  Two authors collected and assessed the data independently. The studies were grouped into two sets according to the type of analysis used to assess the relationship between cerebral autoregulation indices and predictors of outcome (standardized mean differences or R).
  
  
  RESULTS
  Thirty-three studies compared cerebral autoregulation indices and patient outcomes using standardized mean differences, and 20 used Rs. The only data available for meta-analysis were from patients with traumatic brain injury or subarachnoid hemorrhage. Based on z score analysis, the best three cerebral autoregulation index predictors of mortality or Glasgow Outcome Scale for patients with traumatic brain injury were the pressure reactivity index, transcranial Doppler-derived mean velocity index based on cerebral perfusion pressure, and autoregulation reactivity index (z scores: 8.97, 6.01, 3.94, respectively). Mean velocity index based on arterial blood pressure did not reach statistical significance for predicting outcome measured as a continuous variable (p = 0.07) for patients with traumatic brain injury. For patients with subarachnoid hemorrhage, autoregulation reactivity index was the only cerebral autoregulation index that predicted patient outcome measured with the Glasgow Outcome Scale as a continuous outcome (R = 0.82; p = 0.001; z score, 3.39). We found a significant correlation between the duration of monitoring and predictive value for mortality (R = 0.78; p < 0.001).
  
  
  CONCLUSIONS
  Three cerebral autoregulation indices, pressure reactivity index, mean velocity index based on cerebral perfusion pressure, and autoregulation reactivity index were the best outcome predictors for patients with traumatic brain injury. For patients with subarachnoid hemorrhage, autoregulation reactivity index was the only cerebral autoregulation index predictor of Glasgow Outcome Scale. Continuous assessment of cerebral autoregulation predicted outcome better than intermittent monitoring.
authors.affiliation: 1Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD.2Department of Anesthesiology & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD.3Department of Anesthesiology, Universidad del Valle, School of Medicine, Cali, Colombia.4Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.5Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Lucia
authors.initials: L
authors.lastname: Rivera-Lara
authors.forename: Andres
authors.initials: A
authors.lastname: Zorrilla-Vaca
authors.forename: Romer
authors.initials: R
authors.lastname: Geocadin
authors.forename: Wendy
authors.initials: W
authors.lastname: Ziai
authors.forename: Ryan
authors.initials: R
authors.lastname: Healy
authors.forename: Richard
authors.initials: R
authors.lastname: Thompson
authors.forename: Peter
authors.initials: P
authors.lastname: Smielewski
authors.forename: Marek
authors.initials: M
authors.lastname: Czosnyka
authors.forename: Charles W
authors.initials: CW
authors.lastname: Hogue
mesh_terms: D062186:Arterial Pressure; D001783:Blood Flow Velocity; D000070642:Brain Injuries, Traumatic / Q000401:mortality / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D023261:Glasgow Outcome Scale; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D011237:Predictive Value of Tests; D013345:Subarachnoid Hemorrhage / Q000401:mortality / Q000503:physiopathology*