title: [The Study of Associations of Polymorphisms of Candidate Gene of Cardiovascular Diseases With Reduction of Glomerular Filtration Rate in Patients With ST Segment Elevation Myocardial Infarction].
abstract: OBJECTIVE
  to study associations of polymorphic genetic variants of inflammatory response, endothelial function, lipid metabolism, and blood coagulation with impaired renal function in patients with ST elevation myocardial infarction (STEMI).
  
  
  METHODS
  We enrolled in the study 171 patients admitted to the Kemerovo Cardiology Dispensary within 24 hours after onset of STEMI. All patients underwent genotype identification of 25 polymorphic variants of 18 major candidate genes for cardiovascular disease. Genotyping was performed with DNA chip SINKAR-1 (Institute of Medical Genetics and LLC "Genomic Diagnosis"). Glomerular filtration rate (GFR) was estimated using serum creatinine level measured at admission.
  
  
  RESULTS
  Comparison of allelic and genotype frequencies of the studied polymorphisms revealed that angiotensin-converting enzyme (ACE) gene rs4291 was associated with decreased GFR: odds ratio (OR) for carriers of rare TT genotype was 2.31 [1.01-5.25], =0.043. Analysis of genotype combinations of ACE rs4343 polymorphism and hepatic lipase gene (LIPC) rs1800588 showed that AA genotype of rs4343 polymorphism in combination with CC genotype of rs1800588 polymorphism was associated with lowest risk of renal dysfunction, whereas GG and AG genotypes of ACE rs4343 in combination with TT and CT genotypes of LIPC rs1800588.
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Zykov
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Makeeva
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Golubenko
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Kashtalap
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Kulish
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: I S
authors.initials: IS
authors.lastname: Bykova
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Kalaeva
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Karetnikova
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: O L
authors.initials: OL
authors.lastname: Barbarash
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2Research Institute of Medical Genetics,Tomsk, Russia; 3Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
mesh_terms: D000483:Alleles; D002318:Cardiovascular Diseases; D005838:Genotype; D005919:Glomerular Filtration Rate / Q000235:genetics; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D000072657:ST Elevation Myocardial Infarction / Q000235:genetics / Q000503:physiopathology