title: The DrugAge database of aging-related drugs.
abstract: Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug-gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
authors.forename: Diogo
authors.initials: D
authors.lastname: Barardo
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Thornton
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.|Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham (Amrita University), Coimbatore, India.
authors.forename: Harikrishnan
authors.initials: H
authors.lastname: Thoppil
authors.affiliation: Energy Metabolism Laboratory, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Walsh
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
authors.forename: Samim
authors.initials: S
authors.lastname: Sharifi
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
authors.forename: Susana
authors.initials: S
authors.lastname: Ferreira
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
authors.forename: Andreja
authors.initials: A
authors.lastname: Anžič
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
authors.forename: Maria
authors.initials: M
authors.lastname: Fernandes
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
authors.forename: Patrick
authors.initials: P
authors.lastname: Monteiro
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
authors.forename: Tjaša
authors.initials: T
authors.lastname: Grum
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
authors.forename: Rui
authors.initials: R
authors.lastname: Cordeiro
authors.affiliation: Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Evandro Araújo
authors.initials: EA
authors.lastname: De-Souza
authors.affiliation: The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva, Israel.|Judea Regional Research & Development Center, Carmel, 90404, Israel.
authors.forename: Arie
authors.initials: A
authors.lastname: Budovsky
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
authors.forename: Natali
authors.initials: N
authors.lastname: Araujo
authors.affiliation: Department of Science, Yale- NUS College, Singapore City, 138527, Singapore.|Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, 117597, Singapore.
authors.forename: Jan
authors.initials: J
authors.lastname: Gruber
authors.affiliation: Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Petrascheck
authors.affiliation: The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: Vadim E
authors.initials: VE
authors.lastname: Fraifeld
authors.affiliation: Pharmaceutical Artificial Intelligence Research Division, Emerging Technology Centers, Insilico Medicine, Inc, Johns Hopkins University at Eastern, B301, 1101 33rd Street, Baltimore, MD, 21218, USA.|The Biogerontology Research Foundation, Oxford, UK.
authors.forename: Alexander
authors.initials: A
authors.lastname: Zhavoronkov
authors.affiliation: Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia.|Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia.|Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, 119991, Russia.
authors.forename: Alexey
authors.initials: A
authors.lastname: Moskalev
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.|The Biogerontology Research Foundation, Oxford, UK.
authors.forename: João Pedro
authors.initials: JP
authors.lastname: de Magalhães
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D019295:Computational Biology / Q000379:methods; D062313:Databases, Pharmaceutical; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D005853:Geriatrics / Q000379:methods; D006801:Humans; D049990:Membrane Transport Modulators / Q000737:chemistry / Q000494:pharmacology*; D053858:Metabolic Networks and Pathways / Q000187:drug effects*; D051379:Mice; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D014584:User-Computer Interface
chemical_list: D000975:Antioxidants; D049990:Membrane Transport Modulators
keywords: bioinformatics; compound; functional genomics; lifespan; longevity; pharmacology