title: Bifunctional squaramide-catalyzed synthesis of chiral dihydrocoumarins via ortho-quinone methides generated from 2-(1-tosylalkyl)phenols.
abstract: A bifunctional squaramide-catalyzed reaction of azlactones with o-quinone methides in situ generated from 2-(1-tosylalkyl)-phenols has been successfully developed under basic conditions, providing an efficient and mild access to chiral dihydrocoumarins bearing adjacent tertiary and quaternary stereogenic centers in high yields with excellent diastereo- and enantioselectivities.
authors.affiliation: State Key Lab of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. gfjiang@hnu.edu.cn and State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China. ygzhou@dicp.ac.cn.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhou
authors.affiliation: State Key Lab of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. gfjiang@hnu.edu.cn.
authors.forename: Mao-Lin
authors.initials: ML
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China. ygzhou@dicp.ac.cn.
authors.forename: Xiang
authors.identifier: http://orcid.org/0000-0002-8698-2951
authors.initials: X
authors.lastname: Gao
authors.affiliation: State Key Lab of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. gfjiang@hnu.edu.cn.
authors.forename: Guo-Fang
authors.identifier: http://orcid.org/0000-0002-2295-7677
authors.initials: GF
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China. ygzhou@dicp.ac.cn.
authors.forename: Yong-Gui
authors.identifier: http://orcid.org/0000-0002-3321-5521
authors.initials: YG
authors.lastname: Zhou