title: Multiple Valvular Complications of Hypereosinophilic Syndrome.
abstract: Endomyocardial fibrosis (EMF) is the most common cardiac abnormality in hyeperosinophilic syndrome (HES), sometimes complicated with mitral valve disease. Mitral valve disease without ventricular manifestation is very rare, however. Case reports link HES to prosthetic valve thrombosis (PVT), but the optimal type of prosthetic valve in HES is not known. Herein is reported the case of a young female HES patient with secondary mitral valve degeneration and severe regurgitation. A mechanical prosthetic valve was implanted six months after she was diagnosed with HES, but despite anticoagulation and antiplatelet therapy she developed PVT three months later. Partially successful thrombolysis was followed by biological prosthetic valve implantation, with no further complications during the subsequent four years. The eosinophil count and treatment for HES was basically unchanged during the follow up period, following the initiation of treatment. Based on these findings it is suggested that, in HES, the implantation of a biological prosthetic valve might be preferable over a mechanical valve.
authors.affiliation: 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.|Heart Center, Semmelweis University, Budapest, Hungary. Electronic correspondence: pozsonyizoltanimre@gmail.com.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Pozsonyi
authors.affiliation: 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Benedek
authors.affiliation: 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Pál
authors.initials: P
authors.lastname: Sármán
authors.affiliation: 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Lívia
authors.initials: L
authors.lastname: Jánoskuti
authors.affiliation: Heart Center, Semmelweis University, Budapest, Hungary.
authors.forename: Tivadar
authors.initials: T
authors.lastname: Hüttl
authors.affiliation: Heart Center, Semmelweis University, Budapest, Hungary.
authors.forename: Astrid
authors.initials: A
authors.lastname: Apor
mesh_terms: D000328:Adult; D005260:Female; D006349:Heart Valve Diseases / Q000209:etiology*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications*; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000601:surgery*; D011183:Postoperative Complications; D011474:Prosthesis Design; D013927:Thrombosis / Q000209:etiology*