title: Thyroid hormone regulation of intestinal epithelial stem cell biology.
abstract: The gastrointestinal tract is a well-characterized target of thyroid hormones and thyroid hormone nuclear receptors TRs, as extensively described in the literature. The paradigm is its important remodelling in amphibians during thyroid hormone-dependent metamorphosis. Interestingly, several studies have described the conservation of this hormonal signal during intestinal development in mammals. Additional data suggested that it may also play a role in intestinal homeostasis, stem cell physiology and progenitor commitment as well as in tumour development. It is worth underlining that in the mammalian intestine the functionality of the TRα1 receptor is coordinated and integrated with other signalling pathways, such as Wnt and Notch, specifically at the level of stem/progenitor cell populations. Here, we summarize these data and concepts and discuss this new role for thyroid hormones and the TRα1 receptor in the biology of intestinal epithelial precursor cells.
authors.affiliation: Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université de Lyon, Université Lyon 1, Centre Léon Bérard, Département de La Recherche, 69000 Lyon, France.
authors.forename: Carla
authors.initials: C
authors.lastname: Frau
authors.affiliation: Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université de Lyon, Université Lyon 1, Centre Léon Bérard, Département de La Recherche, 69000 Lyon, France.
authors.forename: Matthias
authors.initials: M
authors.lastname: Godart
authors.affiliation: Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université de Lyon, Université Lyon 1, Centre Léon Bérard, Département de La Recherche, 69000 Lyon, France. Electronic address: michelina.plateroti@univ-lyon1.fr.
authors.forename: Michelina
authors.initials: M
authors.lastname: Plateroti
mesh_terms: D000663:Amphibians / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D000818:Animals; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006706:Homeostasis / Q000235:genetics; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000166:cytology; D008675:Metamorphosis, Biological / Q000235:genetics; D051379:Mice; D051880:Receptors, Notch / Q000235:genetics* / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D013961:Thyroid Gland / Q000502:physiology; D037021:Thyroid Hormone Receptors alpha / Q000235:genetics* / Q000378:metabolism; D013963:Thyroid Hormones / Q000235:genetics* / Q000378:metabolism; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism; D060449:Wnt Signaling Pathway
chemical_list: D051880:Receptors, Notch; D037021:Thyroid Hormone Receptors alpha; D013963:Thyroid Hormones; D051153:Wnt Proteins
keywords: Intestinal epithelium; Stem cells; Thyroid hormone; Thyroid hormone receptor TR; Wnt and notch pathways