title: Spindle cell oncocytoma: Report of two cases with massive bleeding and review of the literature.
abstract: Spindle cell oncocytoma (SCO) is a rare pituitary tumor, classified as a WHO grade I neoplasm. Due to its rarity, SCO is often preoperatively misdiagnosed as a pituitary macroadenoma. In the present study we report two recent cases of SCO, a 61-year-old male and a 65-year-old female presenting at Treviso General Hospital between March 2014 and April 2015. Tumor resection was achieved by endoscopic transsphenoidal approach but massive hemorrhagic events hampered surgery, endangering the patient's life in both cases. Both tumors featured fascicles of spindle cells with eosiniphilic cytoplasm expressing vimentin, S-100 and thyroid transcription factor-1 (TTF-1). The diagnosis of SCO was confirmed by second opinion in both cases. Extensive review of available literature, about 30 cases from 2002 to 2015, provided valuable clinical data for preoperative diagnosis and surgical removal of SCO tumors.
authors.affiliation: Department of Neurosurgery, Treviso Regional Hospital, University of Padova, Treviso, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Billeci
authors.affiliation: Department of Neurosurgery, Treviso Regional Hospital, University of Padova, Treviso, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Marton
authors.affiliation: Department of Neurosurgery, Treviso Regional Hospital, University of Padova, Treviso, Italy. Electronic address: egiordan@ulss.tv.it.
authors.forename: Enrico
authors.initials: E
authors.lastname: Giordan
authors.affiliation: Department of Pathology, Treviso Regional Hospital, University of Padova, Treviso, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Carraro
authors.affiliation: Department of Neuroradiology, Treviso Regional Hospital, University of Padova, Treviso, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Ronzon
authors.affiliation: Department of Pathology, Treviso Regional Hospital, University of Padova, Treviso, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Rossi
mesh_terms: D018249:Adenoma, Oxyphilic / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D000368:Aged; D002543:Cerebral Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000000981:diagnostic imaging / Q000601:surgery; D010911:Pituitary Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D012017:Referral and Consultation
keywords: Bleeding macroadenoma; Oncocytoma adenohypophysis; Pituitary bleeding; Pituitary gland; Rare pituitary neoplasm; Spindle cell oncocytoma