title: T1 polymorphism in a disintegrin and metalloproteinase 33 (ADAM33) gene may contribute to the risk of childhood asthma in Asians.
abstract: OBJECTIVE
  Polymorphisms in ADAM33 gene have been implicated in susceptibility to the risk of childhood asthma. However, the results remain controversial. We performed meta-analyses to clarify the relationship between them.
  
  
  METHODS
  Relevant articles were searched in PubMed, Embase, Wanfang, and China National Knowledge Infrastructure. The Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the associations.
  
  
  RESULTS
  Fourteen studies with five ADAM33 polymorphisms (F + 1, T1, T2, S2, and V4) were identified, involving 2687 cases and 2996 controls. ADAM33 F + 1, T2, and T1 polymorphisms showed significant associations with asthma risks in the overall and Caucasian children, Asian children, and Caucasian and Chinese children, respectively; however, these significant results were unstable in sensitivity analysis. T1 revealed significant and stable associations with asthma risks among Asian children in the dominant (OR = 2.00, 95% CI = 1.40-2.87, P = 0.0002) and codominant (OR = 3.06, 95% CI = 1.71-5.50, P = 0.0002) models; in cumulative meta-analyses, these significant results were robust. Concerning S2 or V4 polymorphism, no significant associations were observed.
  
  
  CONCLUSIONS
  These findings demonstrate that ADAM33 T1 polymorphism might be a potential susceptible predictor of asthma for Asian children. Further functional studies between this polymorphism and asthma risks are warranted.
authors.affiliation: Department of Neonatology, Chongqing Health Center for Women and Children, Chongqing Obstetrics and Gynecology Hospital, 64 Jing Tang street, Yu Zhong District, Chongqing, 400013, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Deng
authors.affiliation: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
authors.forename: Fengyan
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Department of Neonatology, Chongqing Health Center for Women and Children, Chongqing Obstetrics and Gynecology Hospital, 64 Jing Tang street, Yu Zhong District, Chongqing, 400013, China. xyzhong1964@163.com.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Zhong
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000293:Adolescent; D044466:Asian People / Q000235:genetics*; D001249:Asthma / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D051722:ADAM Proteins; C450441:ADAM33 protein, human
keywords: ADAM33; Asthma; Childhood; Meta-analysis; Polymorphism