title: [Degenerative Aortic Stenosis: Modern View on Development, Course, and Management].
abstract: Degenerative aortic stenosis is an acquired heart defect manifesting as progressive thickening and calcification of leaflets of originally normal tricuspid or congenital bicuspid aortic valve with development of orifice narrowing, left ventricular hypertrophy, and high risk of cardiovascular complications. In this review we present modern concepts of formation and progression of degenerative aortic stenosis and discuss optimal methods of management of this disease.
authors.affiliation: Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Center, Moscow, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Burdeinaya
authors.affiliation: Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Center, Moscow, Russia.
authors.forename: M S
authors.initials: MS
authors.lastname: Safarova
authors.affiliation: Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Center, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Ezhov
authors.affiliation: Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Center, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Kukharchuk
mesh_terms: D001024:Aortic Valve Stenosis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D002114:Calcinosis; D006330:Heart Defects, Congenital; D006801:Humans; D017379:Hypertrophy, Left Ventricular
keywords: aortic stenosis; heart defect; investigation methods; treatment