title: Fungemia due to Saprochaete capitata in a non-neutropenic patient hospitalized in an intensive care unit after cardiac surgery.
abstract: The majority of invasive fungal infections observed in non-neutropenic patients hospitalized in an intensive care unit are caused by Candida spp and current guidelines recommend echinocandins as the first-line treatment. Fungemias caused by filamentous or arthrosporic fungi such as Saprochaete capitata (previously named Geotrichum capitatum) are extremely rare. In fact, invasive infections due to S. capitata have been reported almost exclusively in neutropenic oncohematological patients. In this report, we describe a case of fungemia caused by S. capitata in a non-neutropenic patient hospitalized in an intensive care unit after aortic valve replacement. The prompt identification of S. capitata is extremely important because of its intrinsic resistance to echinocandins.
authors.affiliation: Microbiology and Virology Unit, IRCCS San Matteo Hospital Foundation, 19, Piazzale Golgi, 27100 Pavia, Italy. Electronic address: c.cavanna@smatteo.pv.it.
authors.forename: C
authors.initials: C
authors.lastname: Cavanna
authors.affiliation: Microbiology and Virology Unit, IRCCS San Matteo Hospital Foundation, 19, Piazzale Golgi, 27100 Pavia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Lallitto
authors.affiliation: Microbiology and Virology Unit, IRCCS San Matteo Hospital Foundation, 19, Piazzale Golgi, 27100 Pavia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Mangione
authors.affiliation: Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Tamarozzi
authors.affiliation: Microbiology and Virology Unit, IRCCS San Matteo Hospital Foundation, 19, Piazzale Golgi, 27100 Pavia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Marone
authors.affiliation: Respiratory Rehabilitation Unit, IRCCS Maugeri Foundation, 27100 Pavia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Ceriana
mesh_terms: D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000534:rehabilitation; D055499:Catheter-Related Infections / Q000382:microbiology; D002405:Catheterization, Central Venous / Q000009:adverse effects; D062905:Central Venous Catheters / Q000382:microbiology; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000627:therapeutic use; D016469:Fungemia / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006760:Hospitalization; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008826:Microbial Sensitivity Tests; D004718:Saccharomycetales / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins
keywords: Echinocandins; Fungemia; Infection fongique; Intensive Care Unit; Non-neutropenic patient; Patients non neutropéniques; Saprochaete capitata; Unité de soins intensifs; Échinocandines