title: Runx1 Structure and Function in Blood Cell Development.
abstract: RUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies.
authors.affiliation: Institute for Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. C.Bonifer@bham.ac.uk.
authors.forename: Constanze
authors.initials: C
authors.lastname: Bonifer
authors.affiliation: Beth Israel Diaconess Medical Center, Harvard Medical School, Boston, MA, USA.|Istituto di Tecnologie Biomediche, Consiglio Nazionale delle Richerche, Pisa, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Levantini
authors.affiliation: Division of Developmental Biology & Medicine, The University of Manchester, Manchester, UK.
authors.forename: Valerie
authors.initials: V
authors.lastname: Kouskoff
authors.affiliation: Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
authors.forename: Georges
authors.initials: G
authors.lastname: Lacaud
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000378:metabolism* / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D002843:Chromatin / Q000378:metabolism; D050676:Core Binding Factor Alpha 2 Subunit / Q000378:metabolism*; D019337:Hematologic Neoplasms / Q000378:metabolism; D006801:Humans; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D002843:Chromatin; D050676:Core Binding Factor Alpha 2 Subunit; D014157:Transcription Factors
keywords: Blood cell development; Chromatin structure; Isoforms; Leukaemia; RUNX1; Regulation of RUNX1 activity; Transcriptional networks