title: An Analysis of Individual Body Fat Depots and Risk of Developing Cancer: Insights From the Dallas Heart Study.
abstract: To examine the association between specific adipose tissue depots and the risk of incident cancer in the Dallas Heart Study.
  
  
  
  Individuals without prevalent cancer in the Dallas Heart Study underwent quantification of adipose depots: visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue, and liver fat by magnetic resonance imaging, and subcutaneous lower-body fat (LBF) by dual-energy X-ray absorptiometry from January 1, 2000, through December 31, 2002, and were observed for the development of cancer for up to 12 years. Multivariable Cox proportional hazards modeling was performed to examine the association between fat depots and cancer.
  
  
  
  Of 2627 participants (median age, 43 years; 69% nonwhite race), 167 (6.4%) developed cancer. The most common primary sites of cancer were the breast (in women) and the prostate (in men). In multivariable models adjusted for age, sex, race, smoking, alcohol use, family history of malignancy, and body mass index, a 1-SD increase in VAT was not associated with increased risk of cancer (hazard ratio [HR], 0.94; 95% CI, 0.77-1.14). In contrast, each 1-SD increase in LBF was associated with a reduced incidence of cancer (HR, 0.69; 95% CI, 0.52-0.92) in the fully adjusted model.
  
  
  
  In this study, adiposity-associated cancer risk was heterogeneous and varied by fat depot: VAT was not independently associated with incident cancer, and LBF seemed to protect against cancer development. Further studies of the adiposity-cancer relationship, including serial assessments, are needed to better elucidate this relationship.
authors.affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Arjun
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Ambarish
authors.initials: A
authors.lastname: Pandey
authors.affiliation: Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Colby
authors.initials: C
authors.lastname: Ayers
authors.affiliation: Division of Oncology, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Muhammad S
authors.initials: MS
authors.lastname: Beg
authors.affiliation: Department of Clinical Cancer Prevention and Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Susan G
authors.initials: SG
authors.lastname: Lakoski
authors.affiliation: Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Gloria L
authors.initials: GL
authors.lastname: Vega
authors.affiliation: Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Scott M
authors.initials: SM
authors.lastname: Grundy
authors.affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: David H
authors.initials: DH
authors.lastname: Johnson
authors.affiliation: Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address: ian.neeland@utsouthwestern.edu.
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Neeland
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D001940:Breast / Q000473:pathology*; D005260:Female; D006801:Humans; D015994:Incidence; D050152:Intra-Abdominal Fat / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000473:pathology; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology; D016016:Proportional Hazards Models; D011467:Prostate / Q000473:pathology*; D012307:Risk Factors; D013223:Statistics as Topic; D050507:Subcutaneous Fat, Abdominal / Q000473:pathology*; D013781:Texas / Q000453:epidemiology