title: The effects of obesity on lung volumes and oxygenation.
abstract: Obesity can cause hypoxemia by decreasing lung volumes to where there is closure of lung units during normal breathing. Studies describing this phenomenon are difficult to translate into clinical practice. We wanted to determine the lung volume measurements that are associated with hypoxemia in obese patients, and explore how we could use these measurements to identify them.
  
  
  
  We collected pulmonary function test results and arterial blood gas data on 118 patients without obstruction on pulmonary function testing. We included only patients with normal chest imaging and cardiac testing within one year of the pulmonary function test, to exclude other causes of hypoxemia.
  
  
  
  We found that as BMI increases, the mean paO2, ERV % predicted, and ERV/TLC decrease (BMI 20-30 kg/m2: paO2=90±8 mmHg, ERV% predicted 112±50, ERV/TLC (%) 19.7±6.5; BMI 30-40 kg/m2: paO2=84±10 mmHg, ERV% predicted 84±40 ERV/TLC(%) 13.6±7.6; BMI>40 kg/m2: paO278 ±12 mmHg, ERV% predicted 64±27 ERV/TLC(%) 11.4±5.8, ANOVA p<0.001). The A-a gradient increases as BMI increases (r=0.42, p<0.001). This correlation was stronger in men (r=0.54) than in women (r=0.35). The paO2is lower in patients with a low ERV than in those with a normal ERV (p<0.001). In a multivariate linear regression, only the ERV/TLC predicted (%), age, and BMI were associated with oxygenation (r2for A-a gradient =0.28, p=0.036).
  
  
  
  In obese patients without cardiopulmonary disease, oxygen levels decrease as BMI increases. This effect is associated with the obesity-related reduction in ERV and is independent of hypoventilation.
authors.affiliation: Loyola University Medical Center, Hines VA Hospital, Department of Medicine, Division of Pulmonary and Critical Care, Maywood, IL, United States. Electronic address: stephen.littleton@va.gov.
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Littleton
authors.affiliation: Cook County Health and Hospitals System, Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Chicago, IL, United States.
authors.forename: Aiman
authors.initials: A
authors.lastname: Tulaimat
mesh_terms: D000328:Adult; D001784:Blood Gas Analysis / Q000295:instrumentation; D015992:Body Mass Index; D005105:Expiratory Reserve Volume / Q000502:physiology; D005260:Female; D005652:Functional Residual Capacity / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology*; D008168:Lung / Q000378:metabolism / Q000503:physiopathology*; D008176:Lung Volume Measurements / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000208:ethnology / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012119:Respiration; D012129:Respiratory Function Tests / Q000379:methods; D013147:Spirometry; D013990:Tidal Volume / Q000502:physiology*
chemical_list: D010100:Oxygen
keywords: Atelectasis; Pulmonary function tests; Pulmonary gas exchange