title: Rapid determination of 54 pharmaceutical and personal care products in fish samples using microwave-assisted extraction-Hollow fiber-Liquid/solid phase microextraction.
abstract: In this paper, a simple, rapid, solvent-less and environmental friendliness microextraction method, microwave-assisted extraction-hollow fiber-liquid/solid phase microextraction (MAE-HF-L/SME), was developed for simultaneous extraction and enrichment of 54 trace hydrophilic/lipophilic pharmaceutical and personal care products (PPCPs) from fish samples. A solid-phase extraction material, solid-phase microextraction (SPME) fiber, was synthesized. The SPME fiber had a homogeneous, loose structure and good mechanical properties, and they exhibited a good adsorption capacity for most PPCPs selected. The material formed the basis for the method of MAE-HF-L/SME. A method of liquid chromatography-high resolution mass spectroscopy (LC-HRMS) for analysis of 54 PPCPs. Under optimal synthesis and extraction conditions, the limits of detection (LODs, n=3) and the limits of quantitation (LOQs, n=10) for the 54 PPCPs were between 0.01-0.50μg·kg-1and 0.052.00μg·kg-1, respectively. Percent recoveries and the relative standard deviations (RSDs) in spiked fish samples (n=6) were between 56.3%-119.9% and 0.3%-17.1%, respectively. The microextraction process of 54 PPCPs in MAE-HF-L/SME took approximately 12min. The method has a low matrix interference and high enrichment factor and may be applicable for determination of 54 different PPCPs in fish samples.
authors.affiliation: Food Inspection and Quarantine Technology Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau of China, Shenzhen, Guangdong, PR China. Electronic address: zhayi80@gmail.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Food Inspection and Quarantine Technology Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau of China, Shenzhen, Guangdong, PR China; School of Chemistry and Environment Engineering Shenzhen University, Shenzhen, Guangdong, PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Guo
authors.affiliation: Food Inspection and Quarantine Technology Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau of China, Shenzhen, Guangdong, PR China.
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Yue
authors.affiliation: Food Inspection and Quarantine Technology Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau of China, Shenzhen, Guangdong, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.affiliation: Food Inspection and Quarantine Technology Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau of China, Shenzhen, Guangdong, PR China.
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Food Inspection and Quarantine Technology Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau of China, Shenzhen, Guangdong, PR China.
authors.forename: Peijin
authors.initials: P
authors.lastname: Chen
authors.affiliation: Food Inspection and Quarantine Technology Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau of China, Shenzhen, Guangdong, PR China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Wu
authors.affiliation: School of Chemistry and Environment Engineering Shenzhen University, Shenzhen, Guangdong, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.affiliation: School of Chemistry and Environment Engineering Shenzhen University, Shenzhen, Guangdong, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Food Inspection and Quarantine Technology Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau of China, Shenzhen, Guangdong, PR China.
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Kuang
authors.affiliation: Food Inspection and Quarantine Technology Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau of China, Shenzhen, Guangdong, PR China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods; D003358:Cosmetics / Q000032:analysis*; D004867:Equipment Design; D005399:Fishes / Q000378:metabolism*; D057230:Limit of Detection; D059627:Liquid Phase Microextraction / Q000295:instrumentation / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D008872:Microwaves; D004364:Pharmaceutical Preparations / Q000032:analysis*; D052617:Solid Phase Microextraction / Q000295:instrumentation / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D003358:Cosmetics; D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical
keywords: Hollow fiber-liquid/solid phase microextraction; Liquid chromatography–high resolution mass spectroscopy (LC–HRMS); Microwave-assisted extraction (MAE); Pharmaceutical and personal care products (PPCPs); Solid-phase microextraction fiber