title: Epigenetics of Atherosclerosis: Emerging Mechanisms and Methods.
abstract: Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls. Vessel occlusion, often occurring after plaque rupture, can result in myocardial and cerebral infarction. Epigenetic changes are increasingly being associated with atherosclerosis and are of interest from both therapeutic and biomarker perspectives. Emerging genomic approaches that profile DNA methylation, chromatin accessibility, post-translational histone modifications, transcription factor binding, and RNA expression in low or single cell populations are poised to enhance our spatiotemporal understanding of atherogenesis. Here, we review recent therapeutically relevant epigenetic discoveries and emerging technologies that may generate new opportunities for atherosclerosis research.
authors.affiliation: Toronto General Hospital Research Institute, University Health Network, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Heart & Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Canada.
authors.forename: Nadiya
authors.initials: N
authors.lastname: Khyzha
authors.affiliation: Heart & Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Canada; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada.
authors.forename: Azad
authors.initials: A
authors.lastname: Alizada
authors.affiliation: Heart & Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Canada; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada. Electronic address: michael.wilson@sickkids.ca.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Wilson
authors.affiliation: Toronto General Hospital Research Institute, University Health Network, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Heart & Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Canada. Electronic address: jason.fish@utoronto.ca.
authors.forename: Jason E
authors.initials: JE
authors.lastname: Fish
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000235:genetics* / Q000276:immunology; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D023281:Genomics; D042421:Histone Code; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology; D016328:NF-kappa B / Q000235:genetics / Q000276:immunology; D011499:Protein Processing, Post-Translational; D062085:RNA, Long Noncoding / Q000235:genetics / Q000276:immunology
chemical_list: D016328:NF-kappa B; D062085:RNA, Long Noncoding
keywords: atherosclerosis; endothelial; epigenetics; inflammation; transcription