title: State-of-the-art fertility preservation in children and adolescents undergoing haematopoietic stem cell transplantation: a report on the expert meeting of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) in Baden, Austria, 29-30 September 2015.
abstract: Nowadays, allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a well-established treatment procedure and often the only cure for many patients with malignant and non-malignant diseases. Decrease in short-term complications has substantially contributed to increased survival. Therefore long-term sequelae are reaching the focus of patient care. One of the most important risks of stem cell transplant survivors is infertility. As well as in the field of allo-HSCT also the field of reproductive medicine has achieved substantial advances to offer potential options for fertility preservation in both boys and girls. Access to these procedures as well as their financing differs significantly throughout Europe. As all European children and adolescents should have the same possibility, the Paediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation organised an expert meeting in September 2015. This manuscript describes the recommendations for the diagnosis and pre-emptive procedures that should be offered to all children and adolescents in Europe who have to undergo an allo-HSCT.
authors.affiliation: Department of Hemato-immunology, Robert-Debre Hospital, APHP, Paris-Diderot University, Paris, France.
authors.forename: J-H
authors.initials: JH
authors.lastname: Dalle
authors.affiliation: Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Lucchini
authors.affiliation: Clinica Pediatrica Università degli Studi di Milano Bicocca, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Ospedale San Gerardo di Monza, Monza, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Balduzzi
authors.affiliation: Department of Pediatric and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Ifversen
authors.affiliation: Division of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, Helsinki University Hospital, Helsinki, Finland.|Department of Women's and Children's Health, Karolinska Institute, University Hospital, Stockholm, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Jahnukainen
authors.affiliation: The Fertility Clinic, Section 4071, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
authors.forename: K T
authors.initials: KT
authors.lastname: Macklon
authors.affiliation: Clinic for Gynaecologic Endocrinology and Reproductive Medicine, University Hospital, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Ahler
authors.affiliation: Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Jarisch
authors.affiliation: Department of Pediatrics, Onco-Hematology Unit, Geneva University Hospitals, Geneva, Switzerland.|CANSEARCH Research Laboratory, Geneva University, Geneva, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Ansari
authors.affiliation: EBMT Paris Office, Hospital Saint Antoine, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Beohou
authors.affiliation: Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Bresters
authors.affiliation: Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital, University of Regensburg, Regensburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Corbacioglu
authors.affiliation: EBMT Paris Office, Hospital Saint Antoine, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Dalissier
authors.affiliation: Department of Pediatric Oncology and Hematology, Hospital Universitario Vall d'Hebron, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Diaz de Heredia Rubio
authors.affiliation: Division of Paediatric Oncology/Haematology, University Children's Hospital of Basel, Basel, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Diesch
authors.affiliation: Department of Paediatric Haematology, Royal Hospital for Children, Glasgow, UK.
authors.forename: B
authors.initials: B
authors.lastname: Gibson
authors.affiliation: Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Klingebiel
authors.affiliation: Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Lankester
authors.affiliation: St Anna Children's Hospital, Universitätsklinik für Kinder- und Jugendheilkunde, Medizinische Universität Wien, Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Lawitschka
authors.affiliation: Clinic for Gynaecologic Endocrinology and Reproductive Medicine, University Hospital, Basel, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Moffat
authors.affiliation: St Anna Children's Hospital, Universitätsklinik für Kinder- und Jugendheilkunde, Medizinische Universität Wien, Vienna, Austria.
authors.forename: C
authors.identifier: http://orcid.org/0000-0003-0369-8515
authors.initials: C
authors.lastname: Peters
authors.affiliation: Adolescents and Young Adults Hematology Unit, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris, University Pierre et Marie Curie, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Poirot
authors.affiliation: Division for Reproductive Endocrinology and Infertility, Department for Gynecology and Obstetrics, University Hospital, Frankfurt, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Saenger
authors.affiliation: Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Sedlacek
authors.affiliation: Paediatric Oncology Unit, Paediatric Transplant Unit, Polytechnic and University Hospital 'LA FE', Valencia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Trigoso
authors.affiliation: Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Vettenranta
authors.affiliation: Department of Pediatric Oncology, Hematology and Transplantology, University of Medical Sciences, Poznan, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Wachowiak
authors.affiliation: Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Willasch
authors.affiliation: Division of Reproductive Medicine and Endocrinology, Department of Obstetrics and Gynaecology, Inselspital Bern, University Hospital, Bern, Switzerland.
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authors.lastname: von Wolff
authors.affiliation: Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Yaniv
authors.affiliation: Department of Pediatrics, Bahcesehir University School of Medicine, Pediatric Stem Cell Transplantation Unit, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Yesilipek
authors.affiliation: Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
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mesh_terms: D000293:Adolescent; D001317:Austria; D002648:Child; D003226:Congresses as Topic; D005060:Europe; D005260:Female; D005298:Fertility; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007247:Infertility, Female / Q000517:prevention & control*; D007248:Infertility, Male / Q000517:prevention & control*; D008297:Male; D012955:Societies, Medical