title: Atorvastatin can ameliorate left atrial stunning induced by radiofrequency ablation for atrial fibrillation.
abstract: The objective of this study was to study the functional changes of the left atrium after radiofrequency ablation treatment for atrial fibrillation and the therapeutic effect of atorvastatin. Fifty-eight patients undergoing radiofrequency ablation for atrial fibrillation were randomly divided into non-atorvastatin group and atorvastatin group. Patients in the atorvastatin group were treated with atorvastatin 20 mg p.o. per night in addition to the conventional treatment of atrial fibrillation; patients in the non-atorvastatin group received conventional treatment of atrial fibrillation only. Echocardiography was performed before radiofrequency ablation operation and 1 week, 2 weeks, 3 weeks, and 4 weeks after operation. Two-dimensional ultrasound speckle tracking imaging system was used to measure the structural indexes of the left atrium. Results indicated that there was no significant change for indexes representing the structural status of the left atrium within a month after radiofrequency ablation (P > 0.05); however, there were significant changes for indexes representing the functional status of the left atrium. There were also significant changes in indexes reflecting left atrial strain status: the S and SRs of atorvastatin group were higher than those of non-atorvastatin group (P < 0.05). In summary, atorvastatin could improve left atrial function and shorten the duration of atrial stunning after radiofrequency ablation of atrial fibrillation.
authors.affiliation: Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.|Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.
authors.forename: Ruiqin
authors.initials: R
authors.lastname: Xie
authors.affiliation: Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.|Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.
authors.forename: Yingtao
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.|Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.|Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.
authors.forename: Hongning
authors.initials: H
authors.lastname: Yin
authors.affiliation: Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.|Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.|Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.
authors.forename: Jidong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.|Department of Cardiology, the Second Hospital of Hebei Medical University. No. 215, West Heping Road, Shijiazhuang, 050000, Hebei, China.
authors.forename: Ling
authors.initials: L
authors.lastname: You
mesh_terms: D000328:Adult; D000368:Aged; D000069059:Atorvastatin / Q000494:pharmacology* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000150:complications / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects*; D005260:Female; D006325:Heart Atria / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology* / Q000528:radiation effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D017682:Myocardial Stunning / Q000150:complications / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D013318:Stroke Volume / Q000187:drug effects / Q000528:radiation effects; D013599:Systole / Q000187:drug effects
chemical_list: D000069059:Atorvastatin
keywords: ablation par radiofréquences; atorvastatin; atorvastatine; atrial fibrillation; atrial stunning; cardiac ultrasound; fibrillation auriculaire; imagerie du suivi du chatoiement à l’échographie; radiofrequency ablation; sidération de l’oreillette; ultrasound speckle tracking imaging; échocardiographie