title: Comparison of influenza and RSV diagnostic from nasopharyngeal swabs by rapid fluorescent immunoassay (Sofia system) and rapid bedside testing (BinaxNOW) vs. conventional fluorescent immunoassay in a German university children's hospital.
abstract: The Sofia fluorescent immunoassay showed excellent sensitivity and specificity compared to conventional fluorescent immunoassay for Influenza A (Influenza B was not detected during the study period) and RSV in patients with suspected ILI (influenza-like illness). Thus the fast and easy-to-handle Sofia FIA leads to rapid and reliable diagnosis, which can be used by clinicians to avoid unnecessary antibiotic treatment and rapidly identify patients who need to be isolated upon hospital admission.
authors.affiliation: Division of Pediatric Infectious Diseases, Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Lindwurmstr. 4, 80337, Munich, Germany. Anita.Rack@med.uni-muenchen.de.
authors.forename: Anita L
authors.initials: AL
authors.lastname: Rack-Hoch
authors.affiliation: Division of Pediatric Infectious Diseases, Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Lindwurmstr. 4, 80337, Munich, Germany.
authors.forename: Gudrun
authors.initials: G
authors.lastname: Laniado
authors.affiliation: Division of Pediatric Infectious Diseases, Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Lindwurmstr. 4, 80337, Munich, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Hübner
mesh_terms: D005455:Fluorescent Antibody Technique / Q000379:methods*; D005858:Germany; D006785:Hospitals, University; D006801:Humans; D009980:Influenza A virus / Q000302:isolation & purification; D007251:Influenza, Human / Q000175:diagnosis* / Q000821:virology; D009305:Nasopharynx / Q000821:virology; D000067716:Point-of-Care Testing; D015203:Reproducibility of Results; D018357:Respiratory Syncytial Virus Infections / Q000175:diagnosis* / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification; D012680:Sensitivity and Specificity
keywords: Child; Influenza; Nasopharyngeal swab; RSV; Rapid fluorescent immunoassay