title: Hepatic perivascular epithelioid cell tumor (PEComa): a case report with a review of literatures.
abstract: Hepatic perivascular epithelioid cell tumors (PEComas) are very rare. We report a primary hepatic PEComa with a review of the literature. A 56-year-old women presented with a nodular mass detected during the management of chronic renal failure and chronic hepatitis C. Diagnostic imaging studies suggested a nodular hepatocellular carcinoma in segment 5 of the liver. The patient underwent partial hepatectomy. A brown-colored expansile mass measuring 3.2×3.0 cm was relatively demarcated from the surrounding liver parenchyma. The tumor was mainly composed of epithelioid cells that were arranged in a trabecular growth pattern. Adipose tissue and thick-walled blood vessels were minimally identified. A small amount of extramedullary hematopoiesis was observed in the sinusoidal spaces between tumor cells. Tumor cells were diffusely immunoreactive for human melanoma black 45 (HMB45) and Melan A, focally immunoreactive for smooth muscle actin, but not for hepatocyte specific antigen (HSA).
authors.affiliation: Department of Pathology, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Hyun-Jin
authors.initials: HJ
authors.lastname: Son
authors.affiliation: Department of Pathology, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kang
authors.affiliation: Department of Pathology, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Joo Heon
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Radiology, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Han
authors.affiliation: Department of Surgery, Cheju Halla General Hospital, Jeju, Korea.
authors.forename: Min Koo
authors.initials: MK
authors.lastname: Lee
mesh_terms: D000199:Actins / Q000378:metabolism; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D058965:MART-1 Antigen / Q000378:metabolism; D058950:Melanoma-Specific Antigens / Q000378:metabolism; D008856:Microscopy, Fluorescence; D054973:Perivascular Epithelioid Cell Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D058951:gp100 Melanoma Antigen
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D000914:Antibodies, Viral; D058965:MART-1 Antigen; C548667:MLANA protein, human; D058950:Melanoma-Specific Antigens; C548637:PMEL protein, human; D058951:gp100 Melanoma Antigen
keywords: HMB45; Hepatic; Melan A; PEComa