title: ERECTA signaling controls Arabidopsis inflorescence architecture through chromatin-mediated activation of PRE1 expression.
abstract: Flowering plants display a remarkable diversity in inflorescence architecture, and pedicel length is one of the key contributors to this diversity. In Arabidopsis thaliana, the receptor-like kinase ERECTA (ER) mediated signaling pathway plays important roles in regulating inflorescence architecture by promoting cell proliferation. However, the regulating mechanism remains elusive in the pedicel. Genetic interactions between ERECTA signaling and the chromatin remodeling complex SWR1 in the control of inflorescence architecture were studied. Comparative transcriptome analysis was applied to identify downstream components. Chromatin immunoprecipitation and nucleosome occupancy was further investigated. The results indicated that the chromatin remodeler SWR1 coordinates with ERECTA signaling in regulating inflorescence architecture by activating the expression of PRE1 family genes and promoting pedicel elongation. It was found that SWR1 is required for the incorporation of the H2A.Z histone variant into nucleosomes of the whole PRE1 gene family and the ERECTA controlled expression of PRE1 gene family through regulating nucleosome dynamics. We propose that utilization of a chromatin remodeling complex to regulate gene expression is a common theme in developmental control across kingdoms. These findings shed light on the mechanisms through which chromatin remodelers orchestrate complex transcriptional regulation of gene expression in coordination with a developmental cue.
authors.affiliation: State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops & Key Laboratory of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education & Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Center for Genomics and Biotechnology, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian Province, China.
authors.forename: Hanyang
authors.initials: H
authors.lastname: Cai
authors.affiliation: State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops & Key Laboratory of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education & Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Center for Genomics and Biotechnology, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian Province, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops & Key Laboratory of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education & Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Center for Genomics and Biotechnology, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian Province, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops & Key Laboratory of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education & Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Center for Genomics and Biotechnology, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian Province, China.
authors.forename: Man
authors.initials: M
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops & Key Laboratory of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education & Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Center for Genomics and Biotechnology, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian Province, China.
authors.forename: Zhenxia
authors.initials: Z
authors.lastname: Su
authors.affiliation: State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops & Key Laboratory of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education & Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Center for Genomics and Biotechnology, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops & Key Laboratory of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education & Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Center for Genomics and Biotechnology, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian Province, China.
authors.forename: Heming
authors.initials: H
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops & Key Laboratory of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education & Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Center for Genomics and Biotechnology, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian Province, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Qin
mesh_terms: D017360:Arabidopsis / Q000033:anatomy & histology / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle / Q000235:genetics; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D018506:Gene Expression Regulation, Plant; D006657:Histones / Q000378:metabolism; D056626:Inflorescence / Q000033:anatomy & histology* / Q000378:metabolism; D020935:MAP Kinase Signaling System; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism; D020929:Mitogen-Activated Protein Kinase Kinases / Q000235:genetics / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D009707:Nucleosomes / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: C507995:ARP6 protein, Arabidopsis; D029681:Arabidopsis Proteins; D002843:Chromatin; D006657:Histones; D008840:Microfilament Proteins; D009707:Nucleosomes; C513126:PRE1 protein, Arabidopsis; D011956:Receptors, Cell Surface; D014157:Transcription Factors; C457763:ER protein, Arabidopsis; D017346:Protein Serine-Threonine Kinases; C458516:AtMPK3 protein, Arabidopsis; C436293:MPK6 protein, Arabidopsis; D020928:Mitogen-Activated Protein Kinases; D020929:Mitogen-Activated Protein Kinase Kinases
keywords: 
  Arabidopsis
  ; ERECTA; H2A.Z; PRE1; SWR1; inflorescence architecture