title: Modular synthesis of supramolecular DNA amphiphiles through host-guest interactions and their self-assembly into DNA-decorated nanovesicles.
abstract: DNA nanostructures have found potential applications in various fields including nanotechnology, materials science and nanomedicine, hence the design and synthesis of DNA nanostructures is extremely important. Self-assembly of DNA amphiphiles provides an efficient strategy for the crafting of soft DNA nanostructures. However, the synthesis of DNA amphiphiles is always challenging. Herein, we show a non-covalent approach based on the host-guest interaction between β-CD and adamantane for the synthesis of DNA amphiphiles, and report their amphiphilicity-driven self-assembly into DNA decorated vesicles. The DNA-directed surface addressability of the vesicles is demonstrated through their surface decoration with Au-NPs through DNA hybridization. Our results suggest that the non-covalent approach represents a simple, efficient and universal method for the synthesis of DNA amphiphiles, and provides an excellent strategy for the creation of smart DNA nanostructures.
authors.affiliation: School of Chemistry, Indian Institute of Science Education and Research-Thiruvananthapuram (IISER-TVM), CET campus, Trivandrum-695016, India. reji@iisertvm.ac.in.
authors.forename: Shine K
authors.initials: SK
authors.lastname: Albert
authors.forename: Hari Veera Prasad
authors.initials: HVP
authors.lastname: Thelu
authors.forename: Murali
authors.initials: M
authors.lastname: Golla
authors.forename: Nithiyanandan
authors.initials: N
authors.lastname: Krishnan
authors.forename: Reji
authors.initials: R
authors.lastname: Varghese
mesh_terms: D057930:Click Chemistry; D004247:DNA / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D009693:Nucleic Acid Hybridization
chemical_list: D004247:DNA