title: Medicinal Plants as Protective Strategies Against Parkinson's Disease.
abstract: Parkinson's disease is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra pars compacta region. An important mechanism contributing to its development is oxidative stress, induced by the imbalance between the endogenous antioxidant defenses and free radicals production. Naturally occurring bioactive compounds exhibit high antioxidant capacity that may help reducing oxidative stress and even reverse the damage induced by ROS. Fruits are particularly rich in phytochemicals with antioxidant effect, and their properties against the development of neurodegenerative diseases are of great interest. This review discusses how the fruits bioactive compounds and synthetic analogs have been assessed for their ability to regulate molecular pathways involved in neuronal survival such as MAPK, Nrf2, and NF-κB, thus elucidating the possible therapeutic and neuroprotective actions of these compounds.
authors.affiliation: Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C. Colombia.
authors.forename: Natalia Areiza
authors.initials: NA
authors.lastname: Mazo
authors.affiliation: Universidad San Sebastian, Lientur 1457, Concepcion, 4030000. Chile.
authors.forename: Valentina
authors.initials: V
authors.lastname: Echeverria
authors.affiliation: Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C. Colombia.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Cabezas
authors.affiliation: Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C. Colombia.
authors.forename: Marco
authors.initials: M
authors.lastname: Avila-Rodriguez
authors.affiliation: Institute of Pharmacy and Translational Medicine, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya St., 119991 Moscow. Russian Federation.
authors.forename: Vadim V
authors.initials: VV
authors.lastname: Tarasov
authors.affiliation: Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Visakhapatnam-530 045, Andhra Pradesh. India.
authors.forename: Nagendra S
authors.initials: NS
authors.lastname: Yarla
authors.affiliation: GALLY International Biomedical Research Consulting LLC, San Antonio, TX. United States.
authors.forename: Gjumrakch
authors.initials: G
authors.lastname: Aliev
authors.affiliation: Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C. Colombia.
authors.forename: George E
authors.initials: GE
authors.lastname: Barreto
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D000978:Antiparkinson Agents / Q000302:isolation & purification / Q000494:pharmacology; D059290:Dopaminergic Neurons / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D010300:Parkinson Disease / Q000503:physiopathology / Q000517:prevention & control*; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D000978:Antiparkinson Agents; D005609:Free Radicals; D018696:Neuroprotective Agents; D028321:Plant Preparations; D017382:Reactive Oxygen Species
keywords: Parkinson's Disease; dopaminergic neurons; neuroprotective fruits; phytochemicals; signaling pathways; transcription factors