title: Peri-Implant Distribution of Polyethylene Debris in Postmortem-Retrieved Knee Arthroplasties: Can Polyethylene Debris Explain Loss of Cement-Bone Interlock in Successful Total Knee Arthroplasties?
abstract: Loss of mechanical interlock between cement and bone with in vivo service has been recently quantified for functioning, nonrevised, cemented total knee arthroplasties (TKAs). The cause of interlocking trabecular resorption is not known. The goal of this study is to quantify the distribution of PE debris at the cement-bone interface and determine if polyethylene (PE) debris is locally associated with loss of interlock.
  
  
  
  Fresh, nonrevised, postmortem-retrieved TKAs (n = 8) were obtained en bloc. Laboratory-prepared constructs (n = 2) served as negative controls. The intact cement-bone interface of each proximal tibia was embedded in Spurr's resin, sectioned, and imaged under polarized light to identify birefringent PE particles. PE wear particle number density was quantified at the cement-bone interface and distal to the interface, and then compared with local loss of cement-bone interlock.
  
  
  
  The average PE particle number density for postmortem-retrieved TKAs ranged from 8.6 (1.3) to 24.9 (3.1) particles/mm2(standard error) but was weakly correlated with years in service. The average particle number density was twice as high as distal (>5mm) to the interface compared to at the interface. The local loss of interlock at the interface was not related to the presence, absence, or particle density of PE.
  
  
  
  PE debris can migrate extensively along the cement-bone interface of well-fixed tibial components. However, the amount of local bone loss at the cement-bone interface was not correlated with the amount of PE debris at the interface, suggesting that the observed loss of trabecular interlock in these well-fixed TKAs may be due to alternative factors.
authors.affiliation: Department of Orthopaedic Surgery, State University of New York Upstate Medical University, Syracuse, New York.
authors.forename: Karen I
authors.initials: KI
authors.lastname: Cyndari
authors.affiliation: Department of Orthopaedic Surgery, State University of New York Upstate Medical University, Syracuse, New York.
authors.forename: Jacklyn R
authors.initials: JR
authors.lastname: Goodheart
authors.affiliation: Department of Orthopaedic Surgery, State University of New York Upstate Medical University, Syracuse, New York.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Miller
authors.affiliation: Department of Orthopaedic Surgery, State University of New York Upstate Medical University, Syracuse, New York.
authors.forename: Megan E
authors.initials: ME
authors.lastname: Oest
authors.affiliation: Department of Orthopaedic Surgery, State University of New York Upstate Medical University, Syracuse, New York.
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Damron
authors.affiliation: Department of Orthopaedic Surgery, State University of New York Upstate Medical University, Syracuse, New York.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Mann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D001843:Bone Cements; D001862:Bone Resorption; D000069343:Bone-Implant Interface; D005260:Female; D006801:Humans; D007717:Knee / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020959:Polyethylene; D019736:Prostheses and Implants; D011475:Prosthesis Failure; D013977:Tibia / Q000601:surgery*
chemical_list: D001843:Bone Cements; D020959:Polyethylene
keywords: aseptic loosening; polyethylene debris; postmortem retrieval; total knee arthroplasty; ultra-high-molecular-weight polyethylene