title: Effect of Kaempferia parviflora on sexual performance in streptozotocin-induced diabetic male rats.
abstract: Kaempferia parviflora Wall. Ex.Baker or Krachidum (KP) has been used locally in medicine and food. It has been claimed that KP has aphrodisia properties; however, no scientific data in support of this function in diabetic model have been reported. This study aimed to investigate the efficacy of KP on sexual behaviour and sperm parameter in streptozotocin (STZ)-induced diabetic male rats. Diabetes was induced in twenty male rats by STZ and divided into four groups: diabetic control group, and 3 treatment groups where KP was dose at 140, 280 and 420 mg/kg orally once a day for 6 weeks. Five normal control rats were treated with vehicle. The body weight, blood glucose, food intake, epididymal sperm parameter, sexual behaviour and serum testosterone level were evaluated. The results showed that KP treatment has no effect on the body weight, blood glucose and food intake in diabetic rats. A significant increase in sperm density in diabetic rats was observed (p < .05) at highest dose of KP. Furthermore, KP treatment demonstrated a significant recovery of sexual behaviour and serum testosterone levels in diabetic rats. These results confirm that KP exhibits aphrodisiac properties that improve the sperm density, testosterone level and sexual performance of STZ-induced diabetic rats.
authors.affiliation: Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand.
authors.forename: T
authors.initials: T
authors.lastname: Lert-Amornpat
authors.affiliation: Department of Environmental Science, Faculty of Environment, Kasetsart University, Bangkok, Thailand.
authors.forename: C
authors.initials: C
authors.lastname: Maketon
authors.affiliation: Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand.|Computational Biomodelling Laboratory for Agricultural Science and Technology (CBLAST), Faculty of Science, Kasetsart University, Bangkok, Thailand.
authors.forename: W
authors.initials: W
authors.lastname: Fungfuang
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental; D004435:Eating / Q000187:drug effects; D004822:Epididymis / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000097:blood; D030521:Zingiberaceae
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts; D013739:Testosterone
keywords: 
  Kaempferia parviflora
  ; diabetes mellitus; rat; sexual performance; testoseterone