title: The Impact of tagSNPs in CXCL16 Gene on the Risk of Myocardial Infarction in a Chinese Han Population.
abstract: CXCL16has been demonstrated to be involved in the development of atherosclerosis and myocardial infarction (MI). Nonetheless, the role of theCXCL16polymorphisms on MI pathogenesis is far to be elucidated. We herein genotyped four tagSNPs inCXCL16gene (rs2304973, rs1050998, rs3744700, and rs8123) in 275 MI patients and 670 control subjects, aimed at probing into the impact ofCXCL16polymorphisms on individual susceptibility to MI. Multivariate logistic regression analysis showed that C allele (OR = 1.31, 95% CI = 1.03-1.66, andP= 0.029) and CC genotype (OR = 1.84, 95% CI = 1.11-3.06, andP= 0.018) of rs1050998 were associated with increased MI risk; and C allele (OR = 0.77, 95% CI = 0.60-0.98, andP= 0.036) of rs8123 exhibited decreased MI risk, while the other two tagSNPs had no significant effect. Consistently, the haplotype rs2304973T-rs1050998C-rs3744700G-rs8123A containing the C allele of rs1050998 and A allele of rs8123 exhibited elevated MI risk (OR = 1.41, 95% CI = 1.02-1.96, andP= 0.037). Further stratified analysis unveiled a more apparent association with MI risk among younger subjects (≤60 years old). Taken together, our results provided the first evidence thatCXCL16polymorphisms significantly impacted MI risk in Chinese subjects.
authors.affiliation: Institute of Aging Research, Guangdong Medical University, Dongguan, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang, China.
authors.forename: Shun
authors.initials: S
authors.lastname: Xu
authors.affiliation: Institute of Aging Research, Guangdong Medical University, Dongguan, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China; Department of Clinical Laboratory, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Institute of Aging Research, Guangdong Medical University, Dongguan, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang, China.
authors.forename: Meng-Yun
authors.initials: MY
authors.lastname: Cai
authors.affiliation: Institute of Aging Research, Guangdong Medical University, Dongguan, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Liang
authors.affiliation: Department of Cardiovascular Disease, The First People's Hospital of Foshan, Foshan, China.
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Cen
authors.affiliation: Department of Cardiovascular Disease, The First People's Hospital of Foshan, Foshan, China.
authors.forename: Xi-Li
authors.initials: XL
authors.lastname: Yang
authors.affiliation: Department of Cardiovascular Disease, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
authors.forename: Can
authors.initials: C
authors.lastname: Chen
authors.affiliation: Institute of Aging Research, Guangdong Medical University, Dongguan, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang, China.
authors.forename: Xinguang
authors.identifier: 0000-0001-6963-1386
authors.initials: X
authors.lastname: Liu
authors.affiliation: Institute of Aging Research, Guangdong Medical University, Dongguan, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang, China.
authors.forename: Xing-Dong
authors.identifier: 0000-0003-4956-0917
authors.initials: XD
authors.lastname: Xiong
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D051116:Receptors, Scavenger / Q000235:genetics*
chemical_list: C423727:CXCL16 protein, human; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC; D051116:Receptors, Scavenger