title: Deletion of a Histone Acetyltransferase Leads to the Pleiotropic Activation of Natural Products in Metarhizium robertsii.
abstract: Histone deacetylation normally decreases the gene expression in organisms. By genome-wide deletions of epigenetic regulators in entomopathogenic fungus Metarhizium robertsii, unexpected activations of orphan secondary metabolite genes have been found upon the disruption of a histone acetyltransferase (HAT) gene Hat1. This led to the characterization of 11 new natural products, including eight isocoumarin derivatives meromusides A-H and two nonribosomal peptides meromutides A and B. Therefore, disruption of HAT represents a new approach to mine chemical diversity from fungi.
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101, China.|Savaid Medical School, University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Aili
authors.initials: A
authors.lastname: Fan
authors.affiliation: Institute of Microbiology, College of Life Science, Zhejiang University , Hangzhou 310058, China.
authors.forename: Wubin
authors.initials: W
authors.lastname: Mi
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Institute of Microbiology, College of Life Science, Zhejiang University , Hangzhou 310058, China.
authors.forename: Guohong
authors.initials: G
authors.lastname: Zeng
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050, China.
authors.forename: Youcai
authors.identifier: 0000-0002-3752-7485
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Institute of Microbiology, College of Life Science, Zhejiang University , Hangzhou 310058, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Fang
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101, China.
authors.forename: Wen-Bing
authors.identifier: 0000-0002-9184-3198
authors.initials: WB
authors.lastname: Yin
mesh_terms: D001688:Biological Products; D051548:Histone Acetyltransferases; D052981:Metarhizium; D015394:Molecular Structure; D013172:Spores, Fungal
chemical_list: D001688:Biological Products; D051548:Histone Acetyltransferases