title: Evidence of metachronous development of ovarian teratomas: a case report of bilateral mature cystic teratomas of the ovaries and systematic literature review.
abstract: BACKGROUND
  Mature cystic teratomas are usually found in the ovaries. They are bilateral in 10 to 15% of cases and multiple cystic teratomas may be present in one ovary. The aim of this study is to clarify if development of mature cystic teratomas of the ovaries in a single host is metachronous or due to autoimplant or recurrence.
  
  
  METHODS
  We report a woman with bilateral mature cystic teratomas of the ovaries. DNA profiles of these teratomas were investigated via short tandem repeat (STR) analysis and methylation statuses were determined via methylation sensitive multiplex ligation-dependent probe amplification methods. The results showed that the cystic teratomas originated from different stages of oogonia or primary oocyte before germinal vesicle stage failure of meiosis I in female gametogenesis. Potentially relevant literature was searched in PubMed database. Cases of bilateral or multiple mature cystic teratomas of the ovaries were analyzed. To date, there has been no reported case of multiple mature cystic teratomas in which clarification of the origin was achieved using molecular genetic methods.
  
  
  CONCLUSIONS
  The results of this case study provide evidence of metachronous development of mature cystic teratomas of the ovaries and may serve as a reference in the management of patients following laparoscopic cystectomy.
authors.affiliation: Department of Obstetrics and Gynecology, Jen-Ai Hospital, Taichung, Taiwan.
authors.forename: Wen-Chung
authors.initials: WC
authors.lastname: Wang
authors.affiliation: Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, No.110, Sec. 1, Chien Kuo N. Road, Taichung, 402, Taiwan, Republic of China. yenchein@csmu.edu.tw.
authors.forename: Yen-Chein
authors.initials: YC
authors.lastname: Lai
mesh_terms: D000328:Adult; D056915:DNA Copy Number Variations; D019175:DNA Methylation; D005260:Female; D056426:Genetic Loci; D006801:Humans; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats; D060787:Neoplasm Grading; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D017422:Sequence Analysis, DNA; D013724:Teratoma / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery
keywords: Mature cystic teratoma; Meiosis; Metachronous; Multiplex ligation-dependent probe amplification analysis; Parthenogenesis; Short tandem repeat analysis