title: T-cell Metabolism as a Target to Control Autoreactive T Cells in β-Cell Autoimmunity.
abstract: An increasing body of evidence indicates that bio-energetic metabolism of activated T cells is a potential target to control the autoimmune response in type 1 diabetes (T1D).
  
  
  
  T-cell activation and proliferation is linked to the cell capacity to provide sufficient energy and biosynthesis molecules to support T-cell growth and division. This makes T cells susceptible to metabolic inhibition for the control of the T-cell response. There is a wide therapeutic arsenal of metabolic inhibitors, including novel classes of drugs that have become recently available. With the current knowledge and availability of metabolic inhibitors, we are now in the position to design a metabolic inhibition strategy to determine whether targeting of autoreactive T cells is an effective strategy to control the process of β-cell destruction in T1D.
authors.affiliation: San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, 20131, Milan, Italy.
authors.forename: Carlotta
authors.initials: C
authors.lastname: Bordignon
authors.affiliation: San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, 20131, Milan, Italy.
authors.forename: Adriana
authors.initials: A
authors.lastname: Canu
authors.affiliation: San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, 20131, Milan, Italy.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Dyczko
authors.affiliation: San Raffaele Vita-Salute University, Via Olgettina 58, 20131, Milan, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Leone
authors.affiliation: San Raffaele Vita-Salute University, Via Olgettina 58, 20131, Milan, Italy. paolo.monti@hsr.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Monti
mesh_terms: D000818:Animals; D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D050417:Insulin-Secreting Cells / Q000276:immunology*; D008213:Lymphocyte Activation; D053858:Metabolic Networks and Pathways; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
keywords: Autoimmunity; Immune-metabolism; T cells; Type 1 diabetes