title: [Composite pheochromocytoma: A rare adrenal tumor].
abstract: BACKGROUND
  Composite pheochromocytoma is a rare tumor of the adrenal medulla composed of pheochromocytoma and neuroblastic tumor. We report the case of a composite pheochromocytoma detected in a patient with neurofibromatosis type 1.
  
  
  METHODS
  A 61-year-old male patient presented occasional sweats with palpitation and moderate high blood pressure. Urinary catecholamine level was increased. CT scan showed a heterogeneous tumor limited to the adrenal gland. Histologically, the tumor showed two components: pheochromocytoma and ganglioneuroma and was diagnosed as a composite pheochromocytoma. This tumor is particularly associated with neurofibromatosis type 1, the NF1 germline gene mutation may be involved in its physiopathology.
  
  
  CONCLUSIONS
  Composite pheochromocytoma is a rare tumor whose pheochromocytoma component is suspected clinically but the final diagnosis is assessed by pathological examination. Prognosis is still difficult to establish due to the rarity of these tumors.
authors.affiliation: Service d'anatomie et cytologie pathologiques, CHU Pontchaillou, 2, rue Henri-le-Guilloux, 35033 Rennes cedex 9, France. Electronic address: gwladysrobinet@gmail.com.
authors.forename: Gwladys
authors.initials: G
authors.lastname: Robinet
authors.affiliation: Service d'anatomie et cytologie pathologiques, CHU Pontchaillou, 2, rue Henri-le-Guilloux, 35033 Rennes cedex 9, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rioux-Leclercq
authors.affiliation: Service d'urologie, CHU Pontchaillou, 2, rue Henri-le-Guilloux, 35033 Rennes cedex 9, France.
authors.forename: Andréa
authors.initials: A
authors.lastname: Manunta
authors.affiliation: Service d'urologie, CHU Pontchaillou, 2, rue Henri-le-Guilloux, 35033 Rennes cedex 9, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Mathieu
authors.affiliation: Service d'anatomie et cytologie pathologiques, hôpital universitaire de La-Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Tissier
authors.affiliation: Service d'urologie, CHU Pontchaillou, 2, rue Henri-le-Guilloux, 35033 Rennes cedex 9, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Peyronnet
authors.affiliation: Service d'anatomie et cytologie pathologiques, CHU Pontchaillou, 2, rue Henri-le-Guilloux, 35033 Rennes cedex 9, France.
authors.forename: Solène-Florence
authors.initials: SF
authors.lastname: Kammerer-Jacquet
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000473:pathology*; D035583:Rare Diseases / Q000473:pathology*
keywords: Adrenal gland; Composite pheochromocytome; Ganglioneuroma; Ganglioneurome; Neurofibromatose type 1; Neurofibromatosis type 1; Phéochromocytome composite; Surrénale