title: Potential Neuroprotective Effects of Adiponectin in Alzheimer's Disease.
abstract: The adipocyte-secreted protein adiponectin (APN) has several protective functions in the peripheral tissues including insulin sensitizing, anti-inflammatory and anti-oxidative effects that may benefit neurodegenerative diseases such as Alzheimer's disease (AD). In addition, dysregulation of cerebral insulin sensitivities and signaling activities have been implicated in AD. Emerging insights into the mechanistic roles of adiponectin and AD highlight the potential therapeutic effects for AD through insulin signaling.
authors.affiliation: Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. royclng@hku.hk.|Research Center of Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. royclng@hku.hk.
authors.forename: Roy Chun-Laam
authors.initials: RC
authors.lastname: Ng
authors.affiliation: Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. koonho@hku.hk.|Research Center of Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. koonho@hku.hk.|Hong Kong University Alzheimer's Disease Research Network, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. koonho@hku.hk.|Neuroimmunology and Neuroinflammation Research Laboratory, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. koonho@hku.hk.
authors.forename: Koon-Ho
authors.initials: KH
authors.lastname: Chan
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D052242:Adiponectin / Q000235:genetics / Q000378:metabolism*; D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D047495:PPAR gamma / Q000819:agonists / Q000378:metabolism
chemical_list: D052242:Adiponectin; D018696:Neuroprotective Agents; D047495:PPAR gamma
keywords: Alzheimer’s disease; Amyloid-β; adiponectin; cognitive impairments