title: Cell-Based Models for Development of Antiatherosclerotic Therapies.
abstract: The leading cause of death worldwide is cardiovascular disease. Among the conditions related to the term, the most prominent one is the development of atherosclerotic plaques in the walls of arteries. The situation gets even worse with the fact that the plaque development may stay asymptomatic for a prolonged period of time. When it manifests as a cardiovascular disorder, it is already too late: the unfortunate individual is prescribed with a plethora of synthetic drugs, which are of debatable efficacy in the prevention of atherosclerotic lesions and safety. Cell models could be useful for the purpose of screening substances potentially effective against atherosclerosis progression and effective in reduction of already present plaques. In this overview, we present studies making use of in vitro and ex vivo models of atherosclerosis development that can prove valuable for clinical applications.
authors.affiliation: Institute of General Pathology and Pathophysiology, Moscow, Russia; INSERM UMR_S 1166-ICAN Faculté de Médecine Pitié-Salpêtrière, Paris, France.
authors.forename: Emile R
authors.identifier: 0000-0002-3811-3399
authors.initials: ER
authors.lastname: Zakiev
authors.affiliation: Institute of General Pathology and Pathophysiology, Moscow, Russia.
authors.forename: Nikita G
authors.identifier: 0000-0002-2082-2429
authors.initials: NG
authors.lastname: Nikiforov
authors.affiliation: Institute of General Pathology and Pathophysiology, Moscow, Russia; Institute for Atherosclerosis Research, Skolkovo Innovation Center, Moscow, Russia.
authors.forename: Alexander N
authors.identifier: 0000-0002-6495-1628
authors.initials: AN
authors.lastname: Orekhov
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008954:Models, Biological; D058226:Plaque, Atherosclerotic / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*