title: IL-1βand IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype.
abstract: Background.Systemic lupus erythematosus (SLE) is an autoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity. To better categorize SLE subtypes, we determined the dominant cytokines based on familial SLE patients.Methods.RF, IgE, and multiple cytokines (i.e., IL-1β, IL-6, IL-8, IL-10, IL-17, IFN-γ, IP-10, MCP-1, and MIP-1β) were measured in sera of familial SLE patients (n= 3), noninherited SLE patients (n= 108), and healthy controls (n= 80).Results.Three familial SLE patients and 5 noninherited SLE cases are with features of RF+IgE+. These RF+IgE+ SLE patients expressed significantly higher levels of IL-1βand IL-6 than the other SLE patients (P< 0.05). IL-6 correlated with both IgE and IL-1βlevels in RF+IgE+ SLE patients (r2= 0.583,P= 0.027;r2= 0.847,P= 0.001), and IgE also correlated with IL-1β(r2= 0.567,P= 0.031).Conclusion.Both IL-1βand IL-6 are highly expressed cytokines in RF+IgE+ SLE subtype which may be related to the pathogenesis of this special SLE subtype and provide accurate treatment strategy by neutralizing IL-1βand IL-6.
authors.affiliation: Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, China.
authors.forename: Yongkang
authors.identifier: 0000-0002-7352-3465
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, China.
authors.forename: Bei
authors.identifier: 0000-0001-9872-6747
authors.initials: B
authors.lastname: Cai
authors.affiliation: Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, China.
authors.forename: Junlong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, China.
authors.forename: Beilei
authors.initials: B
authors.lastname: Shen
authors.affiliation: Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, China.
authors.forename: Zhuochun
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Rheumatology, West China Hospital Affiliated to Sichuan University, Chengdu, China.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Tan
authors.affiliation: Department of Internal Medicine, Sector Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands.
authors.forename: Carla C
authors.initials: CC
authors.lastname: Baan
authors.affiliation: Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, China.
authors.forename: Lanlan
authors.identifier: 0000-0002-1640-7839
authors.initials: L
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D053583:Interleukin-1beta / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D012217:Rheumatoid Factor / Q000097:blood*; D055815:Young Adult
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6; D007073:Immunoglobulin E; D012217:Rheumatoid Factor