title: Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis.
abstract: Autophagy can eliminate harmful components and maintain cellular homeostasis in response to a series of extracellular insults in eukaryotes. More and more studies show that autophagy plays vital roles in the development of atherosclerosis. Atherosclerosis is a multifactorial disease and shear stress acts as a key role in its process. Understanding the role of shear stress in autophagy may offer insight into atherosclerosis therapies, especially emerging targeted therapy. In this article, we retrospect related studies to summarize the present comprehension of the association between autophagy and atherosclerosis onset and progression.
authors.affiliation: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University , Guangzhou, China .
authors.forename: Feng-Xia
authors.initials: FX
authors.lastname: Guo
authors.affiliation: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University , Guangzhou, China .
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Hu
authors.affiliation: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University , Guangzhou, China .
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University , Guangzhou, China .
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology* / Q000473:pathology*; D001343:Autophagy / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D033081:Shear Strength / Q000502:physiology*; D013314:Stress, Mechanical
keywords: atherosclerosis; autophagy; endothelial cells; macrophage; shear stress; vascular smooth muscle cells