title: Prevalence of Human Papillomavirus infection among Chilean women from 2012 to 2016.
abstract: Here, we evaluated the prevalence of Human Papillomavirus (HPV) in two groups of Chilean women. The first group consisted of 3235 women aged 18-64 years attended in six primary care centers of Santiago. The second group consisted of 456 women 18-85 aged who consulted the Gynaecology Department of the Reference Hospital of Santiago. Samples were collected from October 2012 to February 2016. Cervical swabs were analyzed both HPV genotyping by PCR and Reverse Line Blot, and cervical cytology by Pap testing. Results showed a prevalence of 12.0% HPV positive, 10.3% high-risk (HR) HPV types positive, 3.9% low-risk (LR) HPV types positive, and 1.0% Pap positive in group 1. The most frequent types were 16, 66, and 59, with a prevalence of 3.0%, 1.6%, and 1.5%, respectively. The prevalence were 71.9% HPV positive, 67.3% HR-HPV types positive, 13.6% LR-HPV types positive, and 62.5% Pap positive in group 2. The most frequent types were 16, 31, and 58, with prevalence of 33.6%, 10.5%, and 7.0%, respectively. Among infected women with HPV: 7.6% were infected with HPV16 or HPV18, 3.0% with HPV31, HPV33 or HPV45, and 6.7% with any other HR-HPV. These findings show great difference in HPV prevalence and types between primary care and reference center, and provide useful epidemiological information to assess the impact of HPV vaccination in the future.
authors.affiliation: Sección Virus Oncogénicos, Subdepto. de Enfermedades Virales, Instituto de Salud Pública de Chile, Santiago, Chile.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Vergara
authors.affiliation: Dirección de Atención Primaria, Servicio de Salud Metropolitano Central, Santiago, Chile.
authors.forename: Gloria
authors.initials: G
authors.lastname: Espinoza
authors.affiliation: Sección Virus Oncogénicos, Subdepto. de Enfermedades Virales, Instituto de Salud Pública de Chile, Santiago, Chile.
authors.forename: Monserrat
authors.initials: M
authors.lastname: Balanda
authors.affiliation: Dirección de Atención Primaria, Servicio de Salud Metropolitano Central, Santiago, Chile.
authors.forename: Andrea
authors.initials: A
authors.lastname: Quiero
authors.affiliation: Dirección de Salud, Municipalidad de Huechuraba, Santiago, Chile.
authors.forename: Wilma
authors.initials: W
authors.lastname: Hidalgo
authors.affiliation: Sección Virus Oncogénicos, Subdepto. de Enfermedades Virales, Instituto de Salud Pública de Chile, Santiago, Chile.
authors.forename: Héctor
authors.initials: H
authors.lastname: San Martín
authors.affiliation: Laboratorio Clínico, Hospital San Juan de Dios, Santiago, Chile.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Ramírez
authors.affiliation: Sección Virus Oncogénicos, Subdepto. de Enfermedades Virales, Instituto de Salud Pública de Chile, Santiago, Chile.|Programa de Virología, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
authors.forename: Eugenio
authors.identifier: 0000-0002-5299-7928
authors.initials: E
authors.lastname: Ramírez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002584:Cervix Uteri / Q000821:virology*; D002677:Chile / Q000453:epidemiology; D005260:Female; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Chilean women; genotypes; human papillomavirus; prevalence