title: [Clinical and Economic Aspects of Meldonium as Part of Physical Rehabilitation Programs in Patients With Coronary Heart Disease After Percutaneous Coronary Interventions].
abstract: to analyze clinical and economical effectiveness of meldonium as component of integrated program of cardio-rehabilitation in patients with ischemic heart disease (IHD) in the early period after percutaneous coronary intervention (PCI) with incomplete revascularization.
  
  
  
  A program of controlled physical training (CPT) was carried out in patients with stable IHD and positive post PCI exercise test (n=48, age less or equal 65 years) starting 8-10 days after PCI. CRT program consisted of 2 phases - inhospital (exercise on treadmill with max heart rate [HR] 80% of that achieved in initial test, 10 times during 2 weeks) and home (exercise on treadmill with max HR 60% of HR achieved in initial test, 3 times a week for 2 months). Before initiation of CRT patients were distributed into 2 groups: CRT without (n=23; 56.7+/-7.1 years) and with (n=25; 54.6+/-6.8 years) administration of meldonium (1000 mg/day intravenously). Control group (n=24; 50+/-8.4 years) consisted of patients who were under outpatient observation, received similar drug therapy, but were not subjected to CRT. After completion of CRT (in 2.5 months) all patients underwent clinical-instrumental examination with determination of exercise tolerance.
  
  
  
  Exercise duration and metabolic equivalent (MET) increased by 43.9, 36.6, 4.1% and 42.1, 34.8, 3.4% in CRT+ meldonium, CRT only, and control groups, respectively.
  
  
  
  In patients with documented ischemia after PCI inclusion of meldonium in the scheme of rehabilitation was associated with improved physical performance and optimal cost-effectiviness.
authors.affiliation: Saratov State Medical University named after V.I. Razumovskiy, Saratov, Russia.
authors.forename: N P
authors.initials: NP
authors.lastname: Lyamina
authors.affiliation: Saratov State Medical University named after V.I. Razumovskiy, Saratov, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Razborov
authors.affiliation: Saratov State Medical University named after V.I. Razumovskiy, Saratov, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Karpov
mesh_terms: D002317:Cardiovascular Agents / Q000191:economics / Q000627:therapeutic use*; D003327:Coronary Disease / Q000191:economics / Q000503:physiopathology / Q000534:rehabilitation* / Q000601:surgery; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008763:Methylhydrazines / Q000191:economics / Q000627:therapeutic use*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000191:economics / Q000503:physiopathology / Q000534:rehabilitation / Q000601:surgery; D062645:Percutaneous Coronary Intervention; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D008763:Methylhydrazines; C050147:3-(2,2,2-trimethylhydrazine)propionate
keywords: cardio-rehabilitation; clinical and cost-effectiveness; coronary heart disease; meldonium