title: Outcome of Non-Invasive Brain Stimulation in Substance Use Disorders: A Review of Randomized Sham-Controlled Clinical Trials.
abstract: Non-invasive brain stimulation (NIBS) might be a new approach to treat substance use disorders (SUD). A systematic review and critical analysis was performed to identify potential therapeutic effects of NIBS on addictions. A search of the Medline database was conducted for randomized sham-controlled trials using NIBS in the field of addiction and published until August 2016. Twenty-six studies in various SUD met the inclusion criteria. Converging evidence indicates that NIBS might be a promising mean to treat patients with alcohol and tobacco use disorders, by acting on craving reduction and other mechanisms such as improvement in cognitive dysfunctions.
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (BT, J-C C-G); the INSERM U1093, Cognition, Action et Plasticité Sensorimotrice, University of Burgundy-Franche-Comté, Dijon, France (BT); the CHU de Nantes, Psychiatric Neuromodulation Unit, Addictology and Liaison Psychiatry Department, Nantes, France (AS, SB); the Laboratory of Canada Research Chair in Cognitive Neuroplasticity, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Quebec, Medical School, Laval University, Québec, Canada (SF); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); the Addiction Division, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland (SA, DZ); and the Addictive Disorders Research Group and Neuroscience Center, University of Geneva, Switzerland (SA, DZ).
authors.forename: Benoit
authors.initials: B
authors.lastname: Trojak
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (BT, J-C C-G); the INSERM U1093, Cognition, Action et Plasticité Sensorimotrice, University of Burgundy-Franche-Comté, Dijon, France (BT); the CHU de Nantes, Psychiatric Neuromodulation Unit, Addictology and Liaison Psychiatry Department, Nantes, France (AS, SB); the Laboratory of Canada Research Chair in Cognitive Neuroplasticity, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Quebec, Medical School, Laval University, Québec, Canada (SF); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); the Addiction Division, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland (SA, DZ); and the Addictive Disorders Research Group and Neuroscience Center, University of Geneva, Switzerland (SA, DZ).
authors.forename: Anne
authors.initials: A
authors.lastname: Sauvaget
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (BT, J-C C-G); the INSERM U1093, Cognition, Action et Plasticité Sensorimotrice, University of Burgundy-Franche-Comté, Dijon, France (BT); the CHU de Nantes, Psychiatric Neuromodulation Unit, Addictology and Liaison Psychiatry Department, Nantes, France (AS, SB); the Laboratory of Canada Research Chair in Cognitive Neuroplasticity, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Quebec, Medical School, Laval University, Québec, Canada (SF); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); the Addiction Division, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland (SA, DZ); and the Addictive Disorders Research Group and Neuroscience Center, University of Geneva, Switzerland (SA, DZ).
authors.forename: Shirley
authors.initials: S
authors.lastname: Fecteau
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (BT, J-C C-G); the INSERM U1093, Cognition, Action et Plasticité Sensorimotrice, University of Burgundy-Franche-Comté, Dijon, France (BT); the CHU de Nantes, Psychiatric Neuromodulation Unit, Addictology and Liaison Psychiatry Department, Nantes, France (AS, SB); the Laboratory of Canada Research Chair in Cognitive Neuroplasticity, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Quebec, Medical School, Laval University, Québec, Canada (SF); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); the Addiction Division, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland (SA, DZ); and the Addictive Disorders Research Group and Neuroscience Center, University of Geneva, Switzerland (SA, DZ).
authors.forename: Laurence
authors.initials: L
authors.lastname: Lalanne
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (BT, J-C C-G); the INSERM U1093, Cognition, Action et Plasticité Sensorimotrice, University of Burgundy-Franche-Comté, Dijon, France (BT); the CHU de Nantes, Psychiatric Neuromodulation Unit, Addictology and Liaison Psychiatry Department, Nantes, France (AS, SB); the Laboratory of Canada Research Chair in Cognitive Neuroplasticity, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Quebec, Medical School, Laval University, Québec, Canada (SF); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); the Addiction Division, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland (SA, DZ); and the Addictive Disorders Research Group and Neuroscience Center, University of Geneva, Switzerland (SA, DZ).
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Chauvet-Gelinier
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (BT, J-C C-G); the INSERM U1093, Cognition, Action et Plasticité Sensorimotrice, University of Burgundy-Franche-Comté, Dijon, France (BT); the CHU de Nantes, Psychiatric Neuromodulation Unit, Addictology and Liaison Psychiatry Department, Nantes, France (AS, SB); the Laboratory of Canada Research Chair in Cognitive Neuroplasticity, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Quebec, Medical School, Laval University, Québec, Canada (SF); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); the Addiction Division, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland (SA, DZ); and the Addictive Disorders Research Group and Neuroscience Center, University of Geneva, Switzerland (SA, DZ).
authors.forename: Sonja
authors.initials: S
authors.lastname: Koch
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (BT, J-C C-G); the INSERM U1093, Cognition, Action et Plasticité Sensorimotrice, University of Burgundy-Franche-Comté, Dijon, France (BT); the CHU de Nantes, Psychiatric Neuromodulation Unit, Addictology and Liaison Psychiatry Department, Nantes, France (AS, SB); the Laboratory of Canada Research Chair in Cognitive Neuroplasticity, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Quebec, Medical School, Laval University, Québec, Canada (SF); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); the Addiction Division, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland (SA, DZ); and the Addictive Disorders Research Group and Neuroscience Center, University of Geneva, Switzerland (SA, DZ).
authors.forename: Samuel
authors.initials: S
authors.lastname: Bulteau
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (BT, J-C C-G); the INSERM U1093, Cognition, Action et Plasticité Sensorimotrice, University of Burgundy-Franche-Comté, Dijon, France (BT); the CHU de Nantes, Psychiatric Neuromodulation Unit, Addictology and Liaison Psychiatry Department, Nantes, France (AS, SB); the Laboratory of Canada Research Chair in Cognitive Neuroplasticity, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Quebec, Medical School, Laval University, Québec, Canada (SF); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); the Addiction Division, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland (SA, DZ); and the Addictive Disorders Research Group and Neuroscience Center, University of Geneva, Switzerland (SA, DZ).
authors.forename: Daniele
authors.initials: D
authors.lastname: Zullino
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (BT, J-C C-G); the INSERM U1093, Cognition, Action et Plasticité Sensorimotrice, University of Burgundy-Franche-Comté, Dijon, France (BT); the CHU de Nantes, Psychiatric Neuromodulation Unit, Addictology and Liaison Psychiatry Department, Nantes, France (AS, SB); the Laboratory of Canada Research Chair in Cognitive Neuroplasticity, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Quebec, Medical School, Laval University, Québec, Canada (SF); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); the Addiction Division, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland (SA, DZ); and the Addictive Disorders Research Group and Neuroscience Center, University of Geneva, Switzerland (SA, DZ).
authors.forename: Sophia
authors.initials: S
authors.lastname: Achab
mesh_terms: D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D019966:Substance-Related Disorders / Q000628:therapy*; D016896:Treatment Outcome
keywords: Alcohol Abuse and Dependence; Drug/Substance Abuse; ECT