title: [Increased vascular density with indirect myocardial revascularization in normal rat hearts].
abstract: The aim of this study was to identify if the interaction of myocardial revascularization methods increases the functional vascular area.
  
  
  
  A 4x3 factorial design was performed in 11 groups, five rats per group, ten samples per rat, evaluated at 45 days postoperative, with different surgical combinations. The magnitude of the interaction was evaluated by immunoexpression of vascular endothelium-derived growth factor, fibroblast growth factor and tyrosine receptor, to allow the activity of vascular endothelium-derived growth factor, fibroblast growth factor and thrombin (Flk-1), as well as vascular area measurement; Both measures were performed by computerized morphometry.
  
  
  
  An increase in immunohistochemical expression and vascular area in direct proportion to the interaction was identified; It can be affirmed (ANOVA p < 0.0001), that with the interaction of all the maneuvers the maximum effect is achieved.
  
  
  
  It is demonstrated that indirect myocardial revascularization has a specific weight within the integral myocardial revascularization with a real impact on cost-benefit and cost-effectiveness.
authors.affiliation: Servicio de Cirugía Cardiotorácica, Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. rierac7@gmail.com.
authors.forename: Carlos
authors.initials: C
authors.lastname: Riera-Kinkel
authors.forename: Rubén
authors.initials: R
authors.lastname: Argüero-Sánchez
authors.forename: Enrique
authors.initials: E
authors.lastname: Foyo-Niembro
authors.forename: Emilio
authors.initials: E
authors.lastname: Castellanos
authors.forename: Patricia
authors.initials: P
authors.lastname: Bravo-Ontiveros
authors.forename: Julio
authors.initials: J
authors.lastname: García-Hernández
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D003097:Collateral Circulation / Q000502:physiology; D003331:Coronary Vessels / Q000254:growth & development* / Q000378:metabolism; D005260:Female; D008297:Male; D009204:Myocardial Revascularization / Q000379:methods*; D018919:Neovascularization, Physiologic; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015415:Biomarkers
keywords: Blood proteins; Cardiac surgical procedures; Myocardial revascularization