title: Cell membrane-derived nanomaterials for biomedical applications.
abstract: The continued evolution of biomedical nanotechnology has enabled clinicians to better detect, prevent, manage, and treat human disease. In order to further push the limits of nanoparticle performance and functionality, there has recently been a paradigm shift towards biomimetic design strategies. By taking inspiration from nature, the goal is to create next-generation nanoparticle platforms that can more effectively navigate and interact with the incredibly complex biological systems that exist within the body. Of great interest are cellular membranes, which play essential roles in biointerfacing, self-identification, signal transduction, and compartmentalization. In this review, we explore the major ways in which researchers have directly leveraged cell membrane-derived biomaterials for the fabrication of novel nanotherapeutics and nanodiagnostics. Such emerging technologies have the potential to significantly advance the field of nanomedicine, helping to improve upon traditional modalities while also enabling novel applications.
authors.affiliation: Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Ronnie H
authors.initials: RH
authors.lastname: Fang
authors.affiliation: Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Yao
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Jean C
authors.initials: JC
authors.lastname: Fang
authors.affiliation: Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: zhang@ucsd.edu.
authors.forename: Liangfang
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D020811:Biomedical Technology / Q000379:methods*; D015374:Biosensing Techniques; D002462:Cell Membrane / Q000378:metabolism*; D016503:Drug Delivery Systems; D006801:Humans; D056747:Immunomodulation; D049329:Nanostructures / Q000737:chemistry*
keywords: Biomimetic nanoparticle; Cell membrane; Detoxification; Drug delivery; Imaging; Immunotherapy