title: Does percutaneous coronary stent implantation increase platelet reactivity?
abstract: High platelet reactivity (PR) values on treatment with clopidogrel are associated with an increased rate of thrombotic events after a percutaneous coronary intervention (PCI). However, we do not know the optimal timing of the performance of the PR measurements. Platelets might be activated during a PCI, which means that the timing of PR measurements, before or after PCI, could influence the outcome. In turn, this could lead to misinterpretation of the patient's response to antiplatelet therapy and a less accurate prediction of the patient's risk of thrombotic events during follow-up. We aimed to evaluate the effect of stent implantation on PR in patients with and without acute coronary syndromes who undergo PCI to assess the optimal timing of PR measurements. A systematic literature search was performed and the results are summarized in this review.
authors.affiliation: Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands; St. Antonius Center for Platelet Function Research, St. Antonius Hospital, Nieuwegein, The Netherlands. Electronic address: p.janssen@antoniusziekenhuis.nl.
authors.forename: P W A
authors.initials: PWA
authors.lastname: Janssen
authors.affiliation: Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands; St. Antonius Center for Platelet Function Research, St. Antonius Hospital, Nieuwegein, The Netherlands; Department of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, The Netherlands.
authors.forename: E A
authors.initials: EA
authors.lastname: Mol
authors.affiliation: Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands; St. Antonius Center for Platelet Function Research, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: S M C
authors.initials: SMC
authors.lastname: Geene
authors.affiliation: Cardiovascular Research Center Aalst OLV Hospital, Aalst, Belgium; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Barbato
authors.affiliation: Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands; St. Antonius Center for Platelet Function Research, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Ten Berg
mesh_terms: D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D000077144:Clopidogrel; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods; D015539:Platelet Activation; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010979:Platelet Function Tests; D015607:Stents / Q000009:adverse effects; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine
keywords: Clopidogrel; Percutaneous coronary intervention; Platelet reactivity; Stenting