title: Predictive value of different covariates influencing pregnancy rate following intrauterine insemination with homologous semen: a prospective cohort study.
abstract: The aim was to examine the value of different covariates in the prediction of intrauterine insemination (IUI) success. Between July 2011 and September 2015, data from 1401 IUI cycles with homologous semen in 556 couples were collected prospectively, by questionnaire, in a tertiary referral infertility centre. Statistical analysis was performed using generalized estimating equations (GEEs). GEEs were used instead of an ordinary logistic regression model to take into account the correlation between observations from the same person. The primary outcome parameter was clinical pregnancy rate (CPR), confirmed with a gestational sac and fetal heartbeat on ultrasonography at 7-8 weeks. An overall CPR of 9.5% per cycle was observed. Univariate statistical analysis revealed female and male age, male smoking, female body mass index, ovarian stimulation and inseminating motile count (IMC) as covariates significantly influencing CPR per cycle. Multivariate GEE analysis revealed that the only valuable prognostic covariates included female age, male smoking and infertility status (i.e. primary/secondary infertility). IMC showed a significant curvilinear relationship, with first an increase and then a decrease in pregnancy rate.
authors.affiliation: Genk Institute for Fertility Technology, Department of Obstetrics and Gynecology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600 Genk, Belgium; Hasselt University, Department of Physiology, Martelarenlaan 42, 3500 Hasselt, Belgium. Electronic address: annelies.thijssen@uhasselt.be.
authors.forename: Annelies
authors.initials: A
authors.lastname: Thijssen
authors.affiliation: Hasselt University, Center for Statistics (CENSTAT), Agoralaan Building D, 3590 Diepenbeek, Belgium.
authors.forename: An
authors.initials: A
authors.lastname: Creemers
authors.affiliation: Hasselt University, Center for Statistics (CENSTAT), Agoralaan Building D, 3590 Diepenbeek, Belgium.
authors.forename: Wim
authors.initials: W
authors.lastname: Van der Elst
authors.affiliation: Genk Institute for Fertility Technology, Department of Obstetrics and Gynecology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600 Genk, Belgium.
authors.forename: Eva
authors.initials: E
authors.lastname: Creemers
authors.affiliation: Genk Institute for Fertility Technology, Department of Obstetrics and Gynecology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600 Genk, Belgium.
authors.forename: Eva
authors.initials: E
authors.lastname: Vandormael
authors.affiliation: Genk Institute for Fertility Technology, Department of Obstetrics and Gynecology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600 Genk, Belgium.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Dhont
authors.affiliation: Genk Institute for Fertility Technology, Department of Obstetrics and Gynecology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600 Genk, Belgium; Hasselt University, Department of Physiology, Martelarenlaan 42, 3500 Hasselt, Belgium.
authors.forename: Willem
authors.initials: W
authors.lastname: Ombelet
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007315:Insemination, Artificial; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D012661:Semen; D055815:Young Adult
keywords: Homologous semen; Intrauterine insemination; Prognostic factor; Prospective cohort study; Success rate