title: [Prognostic Significance of Erythropoietin in Patients With Acute Coronary Syndrome].
abstract: to investigate the prognostic role of erythropoietin (EPO) in patients with acute coronary syndrome (ACS).
  
  
  
  Eighty-four patients (46 men, 38 women, mean age 63+/-11 years) with ACS were studied. Twenty-one patients had ST-elevation myocardial infarction (STEMI), 12 - non-ST-elevation myocardial infarction, 51 - unstable angina (UA). Ten patients with STEMI received thrombolytic therapy. Coronary angiography during hospitalization was criterion for exclusion from the study. Serum EPO was measured at hospital admission.
  
  
  
  In-hospital mortality was 5%. Median EPO serum level was higher among patients who died (78.1 [27.8-143.5] vs. 9.0 [6.4-14.1]I.U./ml, p=0.004). Acute kidney injury (AKI) was observed in 7 patients with myocardial infarction (21%) and only in 1 with UA.EPO >10.5 I.U./ml was a significant predictor of AKI development (area under curve 0.73; sensitivity 71%, specificity 67%).
  
  
  
  The results of the present study indicate that in patients with ACS admission serum level of EPO may be an important biomarker of development of AKI and in-hospital mortality.
authors.affiliation: Ulyanovsk State University, Ulyanovsk, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Menzorov
authors.affiliation: Ulyanovsk State University, Ulyanovsk, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Shutov
authors.affiliation: Ulyanovsk State University, Ulyanovsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Larionova
authors.affiliation: Ulyanovsk State University, Ulyanovsk, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Strakhov
authors.affiliation: Ulyanovsk State University, Ulyanovsk, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Serova
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000503:physiopathology; D000368:Aged; D000789:Angina, Unstable; D015415:Biomarkers; D017023:Coronary Angiography; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D015415:Biomarkers; C554270:EPO protein, human; D004921:Erythropoietin
keywords: acute coronary syndrome; acute heart failure; acute kidney injury; biomarkers; erythropoietin; prognosis