title: A novel zebrafish-based model of nociception.
abstract: Chronic pain affects the lives of millions yearly, but few new treatments are available. Due to decreasing budgets and increasing costs of preclinical research, alternatives are sought with high translatability and low cost. Here we demonstrate the utility of a zebrafish-based model of nociception to serve as a novel screening tool for analgesic drugs. Zebrafish swimming behavior was measured following administration of various algogens including histamine, cinnamaldehyde, mustard oil, acetic acid and complete Freund's adjuvant. All compounds reduce distance traveled, thought to be an expression of nociception. Additionally, the suppression of swimming was attenuated by administration of the common analgesic, morphine. Together these data provide support for the use of zebrafish as a cost-effective and translatable model of nociception.
authors.affiliation: Department of Biology, University of Alabama at Birmingham, Birmingham, USA.
authors.forename: J Christopher
authors.initials: JC
authors.lastname: Taylor
authors.affiliation: Department of Psychology, University of Alabama at Birmingham, Birmingham, USA.
authors.forename: L Savannah
authors.initials: LS
authors.lastname: Dewberry
authors.affiliation: Department of Psychology, University of Alabama at Birmingham, Birmingham, USA.
authors.forename: Stacie K
authors.initials: SK
authors.lastname: Totsch
authors.affiliation: Department of Psychology, University of Alabama at Birmingham, Birmingham, USA.
authors.forename: Lindsey R
authors.initials: LR
authors.lastname: Yessick
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, USA.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: DeBerry
authors.affiliation: Department of Biology, University of Alabama at Birmingham, Birmingham, USA.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Watts
authors.affiliation: Department of Psychology, University of Alabama at Birmingham, Birmingham, USA. Electronic address: rsorge@uab.edu.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Sorge
mesh_terms: D019342:Acetic Acid / Q000633:toxicity; D000171:Acrolein / Q000031:analogs & derivatives / Q000633:toxicity; D000701:Analgesics, Opioid / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005620:Freund's Adjuvant / Q000633:toxicity; D006632:Histamine / Q000633:toxicity; D017442:Histamine Agonists / Q000633:toxicity; D008297:Male; D009020:Morphine / Q000494:pharmacology* / Q000627:therapeutic use*; D009149:Mustard Plant / Q000633:toxicity; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D059225:Nociception / Q000187:drug effects*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010938:Plant Oils / Q000633:toxicity; D013550:Swimming; D015027:Zebrafish
chemical_list: D000701:Analgesics, Opioid; D000972:Antineoplastic Agents, Phytogenic; D017442:Histamine Agonists; D009292:Narcotic Antagonists; D010938:Plant Oils; D009270:Naloxone; D009020:Morphine; D000171:Acrolein; D006632:Histamine; D005620:Freund's Adjuvant; D019342:Acetic Acid; C012843:cinnamaldehyde; C027793:mustard oil
keywords: Behavior; Model; Nociception; Nociceptors; Pain; Zebrafish