title: Diversity-Oriented Synthesis of Libraries Based on Benzofuran and 2,3-Dihydrobenzofuran Scaffolds.
abstract: Benzofuran and 2,3-dihydrobenzofuran scaffolds are core components in a large number of biologically active natural and synthetic compounds including approved drugs. Herein, we report efficient synthetic protocols for preparation of libraries based on 3-carboxy 2-aryl benzofuran and 3-carboxy 2-aryl trans-2,3-dihydrobenzofuran scaffolds using commercially available salicylaldehydes, aryl boronic acids or halides and primary or secondary amines. The building blocks were selected to achieve variation in physicochemical properties and statistical molecular design and subsequent synthesis resulted in 54 lead-like compounds with molecular weights of 299-421 and calculated octanol/water partition coefficients of 1.9-4.7.
authors.affiliation: Department of Chemistry, Umeå University , SE90187 Umeå, Sweden.
authors.forename: Liena
authors.initials: L
authors.lastname: Qin
authors.affiliation: Department of Chemistry, Umeå University , SE90187 Umeå, Sweden.
authors.forename: Duc-Duy
authors.initials: DD
authors.lastname: Vo
authors.affiliation: Department of Chemistry, Umeå University , SE90187 Umeå, Sweden.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Nakhai
authors.affiliation: Department of Chemistry, Umeå University , SE90187 Umeå, Sweden.
authors.forename: C David
authors.initials: CD
authors.lastname: Andersson
authors.affiliation: Department of Chemistry, Umeå University , SE90187 Umeå, Sweden.
authors.forename: Mikael
authors.identifier: 0000-0002-3219-4669
authors.initials: M
authors.lastname: Elofsson
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D000586:Amination; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D001572:Benzofurans; D001897:Boronic Acids; D054852:Small Molecule Libraries; C013243:salicylaldehyde; C043168:coumaran
keywords: 2,3-dihydrobenzofuran; benzofuran; diversity oriented synthesis