title: [The Impact of Renal Dysfunction on Outcomes of In-Hospital and Remote Periods in Patients With ST-Elevation Myocardial Infarction Combined With Type 2 Diabetes Mellitus].
abstract: OBJECTIVE
  To elucidate association of renal dysfunction (RD) with unfavorable outcomes of in-hospital and long-term (1 year) treatment stages of patients with ST-elevation (STE) myocardial infarction (MI) and concomitant diabetes mellitus (DM).
  
  
  METHODS
  We enrolled in this register study 954 patients (65% men, 35% women, mean age 63.4 [62.6-64.2] years) with STE acute coronary syndrome. Mean age of men was 60.3 (59.4-61.1), of women - 69.2 [68.1-70.4] years. DM was verified in 175 patients (18.3%) basing on history data and values of fasting and postprandial glycaemia. Glomerular filtration rate (GFR) was calculated by MDRD formula using serum creatinine level determined at admission.
  
  
  RESULTS
  Four groups of patients were distinguished depending on the presence of DM and RD: with DM and RD (n=82), with DM without RD (n=93), without DM with RD (n=269) and without DM and RD (n=510). Presence of RD in acute period of MI was associated with 3.3-fold increase of risk of in-hospital and annual mortality, while the presence of DM was associated with 1.6-fold increase of in-hospital mortality without significant impact on annual mortality.
  
  
  CONCLUSIONS
  RD had a significant impact on realization of poor outcomes in STEMI patients with concomitant DM. Prognostic significance of combination of DM and RD was proved to be higher than that of isolated DM.
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2State Educational Institution of Higher Professional Education Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Karetnikova
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2State Educational Institution of Higher Professional Education Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Evseeva
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2State Educational Institution of Higher Professional Education Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Zykov
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2State Educational Institution of Higher Professional Education Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: I S
authors.initials: IS
authors.lastname: Bykova
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2State Educational Institution of Higher Professional Education Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Kalaeva
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2State Educational Institution of Higher Professional Education Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: K S
authors.initials: KS
authors.lastname: Shafranskaya
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2State Educational Institution of Higher Professional Education Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Kashtalap
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2State Educational Institution of Higher Professional Education Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Gruzdeva
authors.affiliation: 1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2State Educational Institution of Higher Professional Education Kemerovo State Medical Academy, Kemerovo, Russia.
authors.forename: O L
authors.initials: OL
authors.lastname: Barbarash