title: Automated detection of the choroid boundary within OCT image data using quadratic measure filters.
abstract: A novel method for the automated detection of the outer choroid boundary within spectral-domain optical coherence tomography image data, based on an image model within the space of functions of bounded variation and the application of quadratic measure filters, is presented. The same method is used for the segmentation of retinal layer boundaries and proves to be suitable even for data generated without special imaging modes and moderate line averaging. Based on the segmentations, an automated determination of the central fovea region and choroidal thickness measurements for this and two adjacent 1-mm regions are provided. The quality of the method is assessed by comparison with manual delineations performed by five trained graders. The study is based on data from 50 children of the ages 8 to 13 that were obtained in the framework of the LIFE Child study at Leipzig University.
authors.affiliation: Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Wagner
authors.affiliation: Leipzig University, Saxonian Incubator for Clinical Translation, Leipzig, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Scheibe
authors.affiliation: Leipzig University, Saxonian Incubator for Clinical Translation, Leipzig, GermanycLeipzig University, Paul-Flechsig-Institute of Brain Research, Leipzig, Germany.
authors.forename: Mike
authors.initials: M
authors.lastname: Francke
authors.affiliation: Leipzig University, Saxonian Incubator for Clinical Translation, Leipzig, GermanycLeipzig University, Paul-Flechsig-Institute of Brain Research, Leipzig, Germany.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Zimmerling
authors.affiliation: Ernst-Abbe-Hochschule Jena-University of Applied Sciences, Department SciTec, Jena, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Frey
authors.affiliation: Leipzig University, LIFE Leipzig Research Center for Civilization Diseases, Leipzig, Germany.
authors.forename: Mandy
authors.initials: M
authors.lastname: Vogel
authors.affiliation: Leipzig University, Saxonian Incubator for Clinical Translation, Leipzig, GermanyfLeipzig University, Institute of Mathematics, Leipzig, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Luckhaus
authors.affiliation: Leipzig University Hospital, Department of Ophthalmology, Leipzig, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Wiedemann
authors.affiliation: Leipzig University, LIFE Leipzig Research Center for Civilization Diseases, Leipzig, GermanyhUniversity Hospital for Children and Adolescents and Center for Pediatric Research, Department of Women and Child Health, Leipzig University, Leipzig, GermanyiLeipzig University, Integrated Research and Treatment Center Adiposity Diseases, Leipzig, Germany.
authors.forename: Wieland
authors.initials: W
authors.lastname: Kiess
authors.affiliation: Leipzig University Hospital, Department of Ophthalmology, Leipzig, Germany.
authors.forename: Franziska G
authors.initials: FG
authors.lastname: Rauscher
mesh_terms: D000293:Adolescent; D002648:Child; D002829:Choroid / Q000000981:diagnostic imaging; D005123:Eye / Q000000981:diagnostic imaging*; D005584:Fovea Centralis / Q000000981:diagnostic imaging; D006801:Humans; D012160:Retina / Q000000981:diagnostic imaging; D041623:Tomography, Optical Coherence