title: Early post-haemorrhagic stroke testosterone and oestradiol levels and long-term risk of death.
abstract: The influence of oestrogen and testosterone replacement on stroke risk has been examined, as well as mechanisms by which oestrogen may protect from post-stroke damage. However, whether testosterone levels in the early time period after haemorrhagic stroke influence long-term mortality has not previously been investigated. We examined whether these concentrations were predictive of risk of death.
  
  
  
  University hospital.
  
  
  
  Prospective study.
  
  
  
  Testosterone and oestrogen levels in the week after haemorrhagic stroke were measured, and the predictive value of these levels and other clinical parameters such as the size, location and severity of the stroke on mortality during the three-year length of the study were assessed.
  
  
  
  Glasgow Coma Scale and low testosterone/oestradiol ratio on post-stroke day 7 were independent predictors of mortality. Stroke location and hematoma volume had no predictive power.
  
  
  
  The testosterone/oestradiol ratio on day 7 after a haemorrhagic stroke is an independent predictor of mortality during later months.
authors.affiliation: a Neurointensive Care Unit , The Second Affiliated Hospital Zhejiang University School of Medicine , Hangzhou , PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Cai
authors.affiliation: a Neurointensive Care Unit , The Second Affiliated Hospital Zhejiang University School of Medicine , Hangzhou , PR China.
authors.forename: Jingbo
authors.initials: J
authors.lastname: Li
authors.affiliation: a Neurointensive Care Unit , The Second Affiliated Hospital Zhejiang University School of Medicine , Hangzhou , PR China.
authors.forename: Shuda
authors.initials: S
authors.lastname: Chen
authors.affiliation: a Neurointensive Care Unit , The Second Affiliated Hospital Zhejiang University School of Medicine , Hangzhou , PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Meng
authors.affiliation: a Neurointensive Care Unit , The Second Affiliated Hospital Zhejiang University School of Medicine , Hangzhou , PR China.
authors.forename: Reng
authors.initials: R
authors.lastname: Ren
authors.affiliation: a Neurointensive Care Unit , The Second Affiliated Hospital Zhejiang University School of Medicine , Hangzhou , PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D004958:Estradiol / Q000097:blood*; D015600:Glasgow Coma Scale; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors; D018709:Statistics, Nonparametric; D020521:Stroke / Q000097:blood / Q000209:etiology / Q000401:mortality; D016019:Survival Analysis; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
chemical_list: D013739:Testosterone; D004958:Estradiol
keywords: GCS score; Haemorrhagic stroke; oestradiol; testosterone