title: Cardiac passive-aggressive behavior? The right ventricle in patients with a left ventricular assist device.
abstract: Right ventricular failure (RVF) affects up to 50% of patients post-left ventricular assist device (LVAD) implantation, and carries significant morbidity and mortality. There is no widely-used long-term mechanical support option for the right ventricle, thus early identification, prevention and medical treatment of RVF is of the upmost importance. Areas covered: A PubMed search was first completed searching 'Right ventricular failure post-LVAD' which yielded 152 results, and a subsequent search was performed under 'RV mechanical support' which yielded 374 results, and was filtered to 'humans' and literature written in English, generating 219 results. We focused this research on pre-operative risk factors identified in the literature for developing RVF-post LVAD implantation, and the medical and surgical treatment options for RVF, including mechanical treatment options. Expert commentary: There is little consensus on pre-operative risk factors that reliably predict RVF post-LVAD implantation. Large prospective randomized trials would help clarify indications for specific medical and surgical therapy. We gather this knowledge in the present article and describe the main RVF remediation modalities. Surgeons and anesthesiologists should help prevent and have a low threshold for initiating supportive treatment for RVF, which may include increasingly invasive therapies up to long-term mechanical RV support.
authors.affiliation: a Division of Cardiac Surgery , University of Ottawa Heart Institute , Ottawa , Canada.
authors.forename: Donna May
authors.initials: DM
authors.lastname: Kimmaliardjuk
authors.affiliation: a Division of Cardiac Surgery , University of Ottawa Heart Institute , Ottawa , Canada.
authors.forename: Marc
authors.initials: M
authors.lastname: Ruel
mesh_terms: D006333:Heart Failure / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology*; D006353:Heart-Assist Devices; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D018497:Ventricular Dysfunction, Right / Q000209:etiology*
keywords: Cardiac device; Right ventricular failure; left ventricular assist device; right ventricular assist device; right ventricular failure risk score