title: Sporulation delay by stable cAMP analogues in the slime moldPhysarum polycephalum.
abstract: Plasmodial cells of the slime moldPhysarum polycephalum become competent for sporulation following a prolonged period of starvation in darkness. Then sporulation can be induced by illumination. Microinjections of the stable (Sp)- and (Rp)-diastereoisomers of adenosine cyclic 3',5' monothionophosphate before and during a sensitive period from the start of illumination until 5 h after lead to a significant delay in the sporulation process.Both of the diastereoisomers of cyclic AMP prolong the time for sporangia to form in darkness. However, the (Sp)-diastereoisomer is more effective and causes morphological changes in plasmodia.The experimental data suggest that cyclic AMP is decisively involved in light-induced differentiation in the lower eukaryotoPhysarum polycephalum.
authors.affiliation: Fachbereich Biologie-Chemie, Universität Bremen, Leobenerstraße, NW 2, D-2800, Bremen 33, Federal Republic of Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Brandt
authors.affiliation: Fachbereich Biologie-Chemie, Universität Bremen, Leobenerstraße, NW 2, D-2800, Bremen 33, Federal Republic of Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Jastorff
authors.affiliation: Fachbereich Biologie-Chemie, Universität Bremen, Leobenerstraße, NW 2, D-2800, Bremen 33, Federal Republic of Germany.
authors.forename: Armin
authors.initials: A
authors.lastname: Hildebrandt
keywords: HPLC; Microinjection; Physarum; Sporangia morphogenesis; cAMP-analogues