title: Comparison of spin-echo echoplanar imaging and gradient recalled echo-based MR elastography at 3 Tesla with and without gadoxetic acid administration.
abstract: OBJECTIVE
  To compare spin-echo echoplanar imaging (SE-EPI) and gradient recalled echo (GRE) MR elastography (MRE) at 3 T with and without gadoxetic acid administration.
  
  
  METHODS
  We included 84 patients who underwent MRE before and after gadoxetic acid administration, each time using SE-EPI and GRE sequences. Diagnostic performance for predicting clinical liver cirrhosis and high-risk oesophageal varices was assessed using the area under the receiver-operating characteristic curve (AUC). The relationships between T2* and success of MRE, and correlations of liver stiffness (LS) values between the two sequences or before and after gadoxetic acid administration, were investigated.
  
  
  RESULTS
  SE-EPI-MRE resulted in a significantly lower failure rate than GRE-MRE (1.19% vs. 10.71%, P = 0.018). Increased T2* was related to higher probability of successful LS measurement (odds ratio, 1.426; P = 0.004). The AUC of SE-EPI-MRE was comparable to that of GRE-MRE for the detection of clinical liver cirrhosis (0.938 vs. 0.948, P = 0.235) and high-risk oesophageal varices (0.839 vs. 0.752, P = 0.354). LS values were not significantly different before and after gadoxetic acid administration.
  
  
  CONCLUSIONS
  SE-EPI-MRE can substitute for GRE-MRE for the detection of clinical liver cirrhosis and high-risk oesophageal varices. SE-EPI-MRE is particularly useful in patients with iron deposition, with lower failure rates than GRE-MRE.
  
  
  CONCLUSIONS
  • LS values are comparable between SE-EPI-MRE and GRE-MRE. • Administration of gadoxetic acid does not influence LS measurement. • The failure rate of SE-EPI-MRE is significantly lower than that of GRE-MRE.
authors.affiliation: Department of Radiology, Chonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Chonbuk, 54907, Korea.
authors.forename: Yong Seek
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Radiology, Chonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Chonbuk, 54907, Korea. pichgo@gmail.com.|Research Institute of Clinical Medicine of Chonbuk National University, 20 Geonji-ro, Deokjin-gu, Jeonju, Chonbuk, 54907, Korea. pichgo@gmail.com.|Biomedical Research Institute of Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Chonbuk, 54907, Korea. pichgo@gmail.com.
authors.forename: Ji Soo
authors.identifier: http://orcid.org/0000-0002-4264-5320
authors.initials: JS
authors.lastname: Song
authors.affiliation: MR Applications Development, Siemens Healthcare, Erlangen, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Kannengiesser
authors.affiliation: Research Institute of Clinical Medicine of Chonbuk National University, 20 Geonji-ro, Deokjin-gu, Jeonju, Chonbuk, 54907, Korea.|Biomedical Research Institute of Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Chonbuk, 54907, Korea.|Department of Internal Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Korea.
authors.forename: Seung Young
authors.initials: SY
authors.lastname: Seo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D017352:Echo-Planar Imaging / Q000379:methods*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D016145:Endoscopy, Digestive System; D004932:Esophageal and Gastric Varices / Q000175:diagnosis*; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results; D018570:Risk Assessment
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
keywords: Gadoxetic acid; Gradient recalled echo; Liver fibrosis; Magnetic resonance elastography; Spin echo