title: Ethical issues in human organoid and gastruloid research.
abstract: Research involving human organoids and gastruloids involves ethical issues associated with their derivation as well as their current and future uses. These include unique issues related to the extent of maturation that can be achievedin vitroor through chimeric research, as well as fundamental ethical considerations such as those concerning the provenance of human biomaterials and the use of gene-editing technologies. Many of these issues are not specifically addressed by existing ethics oversight mechanisms, but these mechanisms might be easily extended to help ensure that human organoid and related research moves forward in an ethically appropriate manner.
authors.affiliation: Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Parkville, Victoria 3010, Australia megan.munsie@unimelb.edu.au.
authors.forename: Megan
authors.identifier: 0000-0003-3588-8321
authors.initials: M
authors.lastname: Munsie
authors.affiliation: Department of Bioethics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
authors.forename: Insoo
authors.initials: I
authors.lastname: Hyun
authors.affiliation: Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD 21205, USA.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Sugarman
mesh_terms: D033041:Embryo Research / Q000941:ethics*; D005775:Gastrula / Q000502:physiology*; D006801:Humans; D009940:Organoids / Q000502:physiology*; D057766:Policy
keywords: Chimera; Ethics; Gastruloids; Organoids; Regulation; Stem cells