title: Prevalence of multiple drug-resistantPlasmodium falciparummalaria cases in Northeast India.
abstract: Two numbers of Plasmodium falciparum field isolates from Gossingpara, Runikhata area in Chirang district of Assam had shown multiple mutations in Pfcrt-dhfr-dhps gene (up to seven mutations: One mutation in Pfcrt gene, three mutations in Pfdhfr gene and three mutations in Pfdhps gene). Similarly, two cases in Bat camp, Miao area under Changlang district of Arunachal Pradesh had shown a total of eight mutations, of which one mutation in Pfcrt gene, three mutations in Pfdhfr gene, three mutations in Pfdhps gene and one mutation in PfATPase6 gene. One case in 3 Miles, Miao area of Changlang district has shown mutations in Pfcrt(one mutation), Pfdhfr(four mutations) and Pfdhps(three mutations) gene. These results indicated that there is an existence of multiple mutant P. falciparum malaria cases in northeastern region of India.
authors.affiliation: Regional Medical Research Centre, NER, Dibrugarh, Assam, India.
authors.forename: Jitendra
authors.initials: J
authors.lastname: Sharma
authors.affiliation: Regional Medical Research Centre, NER, Dibrugarh, Assam, India.
authors.forename: Siraj Ahmed
authors.initials: SA
authors.lastname: Khan
authors.affiliation: Regional Medical Research Centre, NER, Dibrugarh, Assam, India.
authors.forename: Monika
authors.initials: M
authors.lastname: Soni
authors.affiliation: Regional Medical Research Centre, NER, Dibrugarh, Assam, India.
authors.forename: Prafulla
authors.initials: P
authors.lastname: Dutta
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics; D000962:Antimalarials / Q000494:pharmacology*; D004351:Drug Resistance; D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000453:epidemiology* / Q000469:parasitology*; D026901:Membrane Transport Proteins / Q000235:genetics; D025261:Mitochondrial Proton-Translocating ATPases / Q000235:genetics; D009154:Mutation; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D015995:Prevalence; D015800:Protozoan Proteins / Q000235:genetics; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics
chemical_list: D000962:Antimalarials; D026901:Membrane Transport Proteins; C416369:PfCRT protein, Plasmodium falciparum; D015800:Protozoan Proteins; D000426:Alcohol Dehydrogenase; D013762:Tetrahydrofolate Dehydrogenase; D025261:Mitochondrial Proton-Translocating ATPases