title: Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease.
abstract: Depression is common in premanifest Huntington's disease (preHD) and results in significant morbidity. We sought to examine how variations in structural and functional brain networks relate to depressive symptoms in premanifest HD and healthy controls. Brain networks were constructed using diffusion tractography (70 preHD and 81 controls) and resting state fMRI (92 preHD and 94 controls) data. A sub-network associated with depression was identified in a data-driven fashion and network-based statistics was used to investigate which specific connections correlated with depression scores. A replication analysis was then performed using data from a separate study. Correlations between depressive symptoms with increased functional connectivity and decreased structural connectivity were seen for connections in the default mode network (DMN) and basal ganglia in preHD. This study reveals specific connections in the DMN and basal ganglia that are associated with depressive symptoms in preHD. Hum Brain Mapp 38:2819-2829, 2017. © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
authors.affiliation: Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: McColgan
authors.affiliation: Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom.|Department of Electronic Engineering, NED University of Engineering and Technology, Karachi, Pakistan.
authors.forename: Adeel
authors.initials: A
authors.lastname: Razi
authors.affiliation: Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom.
authors.forename: Sarah
authors.initials: S
authors.lastname: Gregory
authors.affiliation: Developmental Imaging and Biophysics Section, UCL Institute of Child Health, London, WC1N 1EH, United Kingdom.
authors.forename: Kiran K
authors.initials: KK
authors.lastname: Seunarine
authors.affiliation: APHP Department of Genetics, Groupe Hospitalier Pitié-Salpêtrière, and Institut du Cerveau et de la Moelle, INSERM U1127, CNRS UMR7225, Sorbonne Universités - UPMC Université Paris VI UMR_S1127, Paris, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Durr
authors.affiliation: Department of Neurology, Leiden University Medical Centre, 2300RC Leiden, The Netherlands.
authors.forename: Raymund
authors.initials: R
authors.lastname: A C Roos
authors.affiliation: Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, British Columbia, V5Z 4H4, Canada.
authors.forename: Blair R
authors.initials: BR
authors.lastname: Leavitt
authors.affiliation: Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom.
authors.forename: Rachael I
authors.initials: RI
authors.lastname: Scahill
authors.affiliation: Developmental Imaging and Biophysics Section, UCL Institute of Child Health, London, WC1N 1EH, United Kingdom.
authors.forename: Chris A
authors.initials: CA
authors.lastname: Clark
authors.affiliation: Department of Biostatistics, University of Iowa, Iowa City, Iowa.
authors.forename: Doug R
authors.initials: DR
authors.lastname: Langbehn
authors.affiliation: Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom.
authors.forename: Geraint
authors.initials: G
authors.lastname: Rees
authors.affiliation: Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom.|National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, United Kingdom.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Tabrizi
mesh_terms: D057565:Apathy; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001931:Brain Mapping; D015331:Cohort Studies; D003866:Depressive Disorder / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000150:complications; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D011569:Psychiatric Status Rating Scales
chemical_list: D010100:Oxygen
keywords: Huntington's disease; brain network; depression; diffusion tractography; functional MRI