title: The Microenvironmental Landscape of Brain Tumors.
abstract: The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here, we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TME in cancer. By developing a comprehensive understanding of the complex and interconnected microenvironmental landscape of brain malignancies we will greatly expand the range of therapeutic strategies available to target these deadly diseases.
authors.affiliation: Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3A 1A3, Canada.
authors.forename: Daniela F
authors.initials: DF
authors.lastname: Quail
authors.affiliation: Ludwig Institute for Cancer Research, University of Lausanne, 1066 Lausanne, Switzerland; Department of Oncology, University of Lausanne, Chemin des Boveresses 155, 1066 Lausanne, Switzerland. Electronic address: johanna@joycelab.org.
authors.forename: Johanna A
authors.initials: JA
authors.lastname: Joyce
mesh_terms: D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000276:immunology* / Q000628:therapy; D003713:Dendritic Cells / Q000502:physiology; D006801:Humans; D008264:Macrophages / Q000502:physiology; D017628:Microglia / Q000502:physiology; D018919:Neovascularization, Physiologic; D009504:Neutrophils / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology; D059016:Tumor Microenvironment; D014945:Wound Healing
keywords: blood-brain barrier; brain metastasis; brain tumor microenvironment; glioma; immunotherapy; tumor-associated macrophage