title: Enzyme distribution patterns in the imaginal wing disc ofDrosophila melanogaster and other diptera : A subdivision of compartments into territories.
abstract: Analysis of the development of the aldehyde oxidase (AO) pattern in the wing pouch ofD. melanogaster showed that the extension of areas with AO activity occurs in steps. This indicates that the activation of this enzyme is regulated in groups of cells. It is proposed to use the term 'territory' for such a cell group. In the wing pouches ofD. melanogaster, D. simulans andMusca, corresponding parts of the disc become AO positive at comparable developmental stages. This indicates that AO becomes active in individual territories in a specific sequence.Borderlines of the distribution pattern of different enzymes in the wing pouch ofDrosophila and other dipteran species are in agreement with those found for the development of the AO pattern or are complementary to them. This indicates the existence of a common set of territories in the wing pouches of all higher diptera. Borderlines of patterns, as caused by different genetic constitution, are also in accord with this set of territories. The borderlines of some territories coincide with the compartmental A/P or D/V boundary. The results support the idea that both the location of compartmental boundaries and that of borderlines of enzyme territories are determined by a single mechanism.The distribution and the shape of the territories in the wing pouch is best explained by the reaction-diffusion model proposed by Meinhardt (1980), which involves three different gradients.
authors.affiliation: Zoological Laboratory, University of Leiden, 2300 RA, Leiden, The Netherlands.
authors.forename: Th E
authors.initials: TE
authors.lastname: Sprey
authors.affiliation: Zoological Laboratory, University of Leiden, 2300 RA, Leiden, The Netherlands.
authors.forename: A A C
authors.initials: AA
authors.lastname: Eskens
authors.affiliation: Department of Biological Sciences, University of Central Florida, 32816, Orlando, Florida, USA.
authors.forename: D T
authors.initials: DT
authors.lastname: Kuhn
keywords: D. melanogaster; Enzyme Patterns; Imaginal discs; Pattern formation; Territories