title: 4-Aminopyridine ameliorates experimental autoimmune neuritis in Lewis rats.
abstract: We investigated the effect of 4-aminopyridine (4-AP) on experimental autoimmune neuritis (EAN) using a 4-AP-treated group in which 4-AP was administered in the diet, and a control group (n=10 per group). Electrophysiological and pathological assessment was performed in the sciatic nerve. The EAN clinical scores were significantly lower in the 4-AP-treated group than in the control group (p<0.05). The motor conductance velocity two weeks post-immunization was significantly higher in the 4-AP-treated group (p<0.05). Finally, 4-AP did not lead to pathological changes. Thus, 4-AP might be a potential therapeutic agent in demyelinating neuropathy.
authors.affiliation: Division of Neurology, Department of Internal Medicine 3, National Defense Medical College, Tokorozawa, Japan; Department of Internal Medicine, Japan Self Defense Forces Hanshin Hospital, Kawanishi, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Moriguchi
authors.affiliation: Department of Neurology, Kinki University School of Medicine, Osaka-Sayama, Japan. Electronic address: miyamoto@med.kindai.ac.jp.
authors.forename: Katsuichi
authors.initials: K
authors.lastname: Miyamoto
authors.affiliation: Department of Neurology, Kinki University School of Medicine, Osaka-Sayama, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
mesh_terms: D015761:4-Aminopyridine / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000187:drug effects / Q000502:physiology; D005620:Freund's Adjuvant / Q000633:toxicity; D008297:Male; D009185:Myelin Proteins / Q000633:toxicity; D009431:Neural Conduction / Q000187:drug effects; D009444:Neuritis, Autoimmune, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D026902:Potassium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew; D018709:Statistics, Nonparametric; D014611:Vaccination / Q000009:adverse effects
chemical_list: D009185:Myelin Proteins; C425263:P2 peptide; D026902:Potassium Channel Blockers; D005620:Freund's Adjuvant; D015761:4-Aminopyridine
keywords: 4-Aminopyridine; Experimental autoimmune neuritis; Guillain-Barré syndrome