title: [Five Year Dynamics of Main Clinical Symptoms in Patients With Ischemic Heart Disease in Russia in Comparison With Other Countries (the CLARIFY Registry)].
abstract: The CLARIFY register (The prospeCtive observational LongitudinAl RegIstry oF patients with stable coronary arterY disease) combined data of outpatients with stable coronary artery disease (CAD) from 45 countries including Russia. Purpose of this publication was to analyze dynamics of stable angina during 5 years of follow up in the Russian CLARIFY cohort compared with cohorts of patients from European and non-European countries.
  
  
  METHODS
  Number of patients recruited in Russia was 2249.
  
  
  RESULTS
  During 5 years of observation proportion of angina decreased by 65.5, 39.5 and 37.0% in Russia, European and non-European countries, respectively. Proportion of patients with heart rate (HR) <60 bpm at the beginning of observation was 17.4, 25.4 and 23.4% in Russia, European and non-European countries, respectively. By the end of 5 years there was a significant increase in the proportion of patients with HR <70 bpm in Russia, while in Europe and other countries response to HR reducing therapy was much more modest. Perhaps this was due to improved treatment of patients recruited in Russia, for example, ivabradine at the end of the observation period was prescribed two times more than in the beginning. Patients from Russia had significantly lower all cause mortality compared with patients recruited in European countries (p<0.03); no significant differences were observed between Russian and European cohorts in cardiovascular mortality and rates of fatal and non-fatal myocardial infarction and stroke.
  
  
  CONCLUSIONS
  Results of the CLARIFY register showed that continuous monitoring of patients with (annual visit and telephone contact between visits) was associated with reduction of angina in stable coronary artery disease from 75 to 58%. Only 26.6% of patients did not reach HR of 70 bpm. During 5 years of follow up mortality from cardiovascular diseases among patients from Russia did not differ from that among patients from non-European countries and was significantly lower than among patients from Europe (RR=0.83, p<0.05).
authors.affiliation: National Research Center for Preventive Medicine, Moscow, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Shalnova
authors.affiliation: National Research Center for Preventive Medicine, Moscow, Russia.
authors.forename: R G
authors.initials: RG
authors.lastname: Oganov On Behalf Of The Participants Registry Clarify
mesh_terms: D003324:Coronary Artery Disease; D005060:Europe; D006801:Humans; D017202:Myocardial Ischemia; D011446:Prospective Studies; D012042:Registries; D012426:Russia
keywords: CLARIFY register; coronary heart disease; stable angina; treatment