title: [Insomnia due to hypnotic abuse].
abstract: Insomnia due to hypnotic abuse and dependence is a common and serious problem of somnology irrespectively of which one comes first: sleep disturbances or drug use. Modern hypnotics demonstrate selective affinity to some types of benzodiazepine receptors. This explains its higher safety profile compared to first-generation hypnotics. Nevertheless, there are reports of dependence and withdrawal syndrome associated with its administration as well. This literature review shows that seizures, hemodynamic and respiratory disturbances are the most dangerous symptoms of withdrawal. Treatment of hypnotic dependence includes detoxication and gradual withdrawal of medicines.
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: M G
authors.initials: MG
authors.lastname: Poluektov
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: P V
authors.initials: PV
authors.lastname: Pchelina
mesh_terms: D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects* / Q000627:therapeutic use; D011963:Receptors, GABA-A; D012640:Seizures / Q000209:etiology; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders
chemical_list: D006993:Hypnotics and Sedatives; D011963:Receptors, GABA-A