title: Inflammation, DNA Damage,Helicobacter pyloriand Gastric Tumorigenesis.
abstract: Helicobacter pylori (H. pylori)is a Gram negative bacterium that colonizes the stomach of almost half human population. It has evolved to escape immune surveillance, establishes lifelong inflammation, predisposing to genomic instability and DNA damage, notably double strand breaks. The epithelial host cell responds by activation of DNA damage repair (DDR) machinery that seems to be compromised by the infection. It is therefore now accepted that genetic damage is a major mechanism operating in cases ofH. pyloriinduced carcinogenesis. Here, we review the data on the molecular pathways involved in DNA damage and DDR activation duringH. pyloriinfection.
authors.affiliation: Gastroenterology Unit, Department of Pathophysiology, School of Medicine, National and Kapodistrian University Athens, Greece.
authors.forename: Polyxeni
authors.initials: P
authors.lastname: Kalisperati
authors.affiliation: Gastroenterology Unit, Department of Pathophysiology, School of Medicine, National and Kapodistrian University Athens, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Spanou
authors.affiliation: Department of Histology and Embryology, School of Medicine, National and Kapodistrian University Athens, Greece.
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Pateras
authors.affiliation: 1st Department of Pathology, Laiko Hospital, School of Medicine, National and Kapodistrian University of Athens Athens, Greece.
authors.forename: Penelope
authors.initials: P
authors.lastname: Korkolopoulou
authors.affiliation: Department of Pediatrics, University of Patras Medical School Patras, Greece.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Varvarigou
authors.affiliation: 1st Department of Surgery, Laiko Hospital, University of Athens, School of Medicine Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Karavokyros
authors.affiliation: Department of Histology and Embryology, School of Medicine, National and Kapodistrian UniversityAthens, Greece; Biomedical Research Foundation of the Academy of AthensAthens, Greece; Faculty of Biology, Medicine and Health Manchester Cancer Research Centre, Manchester Academic Health Sciences Centre, The University of ManchesterManchester, UK.
authors.forename: Vassilis G
authors.initials: VG
authors.lastname: Gorgoulis
authors.affiliation: Department of Pathophysiology, School of Medicine, National and Kapodistrian University Athens, Greece.
authors.forename: Panayiotis G
authors.initials: PG
authors.lastname: Vlachoyiannopoulos
authors.affiliation: Gastroenterology Unit, Department of Pathophysiology, School of Medicine, National and Kapodistrian University Athens, Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Sougioultzis
keywords: DNA damage repair (DDR); Helicobacter pylori (H. pylori); chronic inflammation; double strand breaks (DSBs); eradication; genomic instability; tumorigenesis; γH2AX