title: Increased Pittsburgh Compound-B Accumulation in the Subcortical White Matter of Alzheimer's Disease Brain.
abstract: Using 11C-Pittsburgh compound B (PiB)-PET and MRI volume data, we investigated whether white matter (WM) PiB uptake in Alzheimer's disease (AD) brain is larger than that of cortical PiB uptake-negative (PiB-negative) brain. Forty-five subjects who underwent both PiB-PET and MRI were included in the study (32 AD patients with cortical PiB-positive and 13 cortical amyloid -negative patients). Individual areas of gray matter (GM) and WM were segmented, then regional GM and WM standard uptake value ratio (SUVR) normalized to cerebellar GM with partial volume effects correction was calculated. Three regional SUVRs except WM in the centrum semiovale in the AD group were significantly larger than those in the PiB-negative groups. Frontal WM SUVR in the AD group vs frontal WM SUVR in the PiB-negative group was 2.57 ± 0.55 vs 1.64 ± 0.22; parietal, 2.50 ± 0.52 vs 1.74 ± 0.22; posterior cingulate, 2.84 ± 0.59 vs 1.73 ± 0.22; and WM in the centrum semiovale, 2.21 ± 0.53 vs 2.42 ± 0.36, respectively. We found that PiB uptake in AD brain is significantly larger than that in PiB-negative brain in the frontal, parietal and posterior cingulate subcortical WM, except in the centrum semiovale.
authors.affiliation: Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Wakabayashi
authors.affiliation: Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Ishii
authors.affiliation: Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Chisa
authors.initials: C
authors.lastname: Hosokawa
authors.affiliation: Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hyodo
authors.affiliation: Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Kaida
authors.affiliation: Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamada
authors.affiliation: Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Yukinobu
authors.initials: Y
authors.lastname: Yagyu
authors.affiliation: Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Tsurusaki
authors.affiliation: Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Takenori
authors.initials: T
authors.lastname: Kozuka
authors.affiliation: Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
authors.forename: Kazuro
authors.initials: K
authors.lastname: Sugimura
authors.affiliation: Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Takamichi
authors.initials: T
authors.lastname: Murakami
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D000814:Aniline Compounds / Q000493:pharmacokinetics*; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013844:Thiazoles / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D066127:White Matter / Q000000981:diagnostic imaging*
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D013844:Thiazoles
keywords: 11C-PiB-PET; Alzheimer's disease; Amyloid deposit; Dementia; White matter