title: Ruxolitinib, a potent JAK1/JAK2 inhibitor, induces temporary reductions in the allelic burden of concurrentCSF3Rmutations in chronic neutrophilic leukemia.
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, London.
authors.forename: Arief S
authors.initials: AS
authors.lastname: Gunawan
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, London.
authors.forename: Donal P
authors.initials: DP
authors.lastname: McLornan
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, London.
authors.forename: Bridget
authors.initials: B
authors.lastname: Wilkins
authors.affiliation: Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust and Faculty of Medicine, University of Southampton, UK.
authors.forename: Katherine
authors.initials: K
authors.lastname: Waghorn
authors.affiliation: Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust and Faculty of Medicine, University of Southampton, UK.
authors.forename: Yvette
authors.initials: Y
authors.lastname: Hoade
authors.affiliation: Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust and Faculty of Medicine, University of Southampton, UK.
authors.forename: Nicholas C P
authors.initials: NCP
authors.lastname: Cross
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, London claire.harrison@gstt.nhs.uk.
authors.forename: Claire N
authors.initials: CN
authors.lastname: Harrison
mesh_terms: D000483:Alleles; D001706:Biopsy; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D004252:DNA Mutational Analysis; D005260:Female; D018628:Gene Dosage; D006801:Humans; D053613:Janus Kinase 1 / Q000037:antagonists & inhibitors; D053614:Janus Kinase 2 / Q000037:antagonists & inhibitors; D015467:Leukemia, Neutrophilic, Chronic / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009154:Mutation; D009570:Nitriles; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D011720:Pyrazoles / Q000494:pharmacology / Q000627:therapeutic use*; D011743:Pyrimidines; D016184:Receptors, Colony-Stimulating Factor / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: C517047:CSF3R protein, human; D009570:Nitriles; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; D016184:Receptors, Colony-Stimulating Factor; C540383:ruxolitinib; D053613:Janus Kinase 1; D053614:Janus Kinase 2