title: Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E.
abstract: Astaxanthin alleviates hepatic lipid accumulation and peroxidation, inflammation, and fibrosis in mice with high-cholesterol, high-cholate, and high-fat (CL) diet-induced nonalcoholic steatohepatitis (NASH) [...].
authors.affiliation: Food Research Institute, National Agriculture and Food Resrach Organization, Tsukuba, Ibaraki 305-8642, Japan. kobori@affrc.go.jp.
authors.forename: Masuko
authors.initials: M
authors.lastname: Kobori
authors.affiliation: Food Research Institute, National Agriculture and Food Resrach Organization, Tsukuba, Ibaraki 305-8642, Japan. yumitala@affrc.go.jp.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Food Research Institute, National Agriculture and Food Resrach Organization, Tsukuba, Ibaraki 305-8642, Japan. imustum@affrc.go.jp.
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Sakurai
authors.affiliation: Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan. shali0145@gmail.com.
authors.forename: Yinhua
authors.initials: Y
authors.lastname: Ni
authors.affiliation: Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan. guanliangc@gmail.com.
authors.forename: Guanliang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan. nakanaga@staff.kanazawa-u.ac.jp.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Nagashimada
authors.affiliation: Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan. skaneko@m-kanazawa.jp.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kaneko
authors.affiliation: Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan. tota@staff.kanazawa-u.ac.jp.
authors.forename: Tsuguhito
authors.initials: T
authors.lastname: Ota
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects; D004195:Disease Models, Animal; D015852:Eukaryotic Initiation Factor-2 / Q000378:metabolism; D020869:Gene Expression Profiling; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D047493:PPAR alpha / Q000378:metabolism; D047494:PPAR delta / Q000378:metabolism; D025941:Protein Interaction Mapping; D060066:Protein Interaction Maps; D000072482:Retinoic Acid Receptor alpha / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D059467:Transcriptome; D014810:Vitamin E / Q000494:pharmacology*; D024341:Xanthophylls / Q000494:pharmacology
chemical_list: D015852:Eukaryotic Initiation Factor-2; D047493:PPAR alpha; D047494:PPAR delta; D000072482:Retinoic Acid Receptor alpha; D024341:Xanthophylls; D014810:Vitamin E; C005948:astaxanthine
keywords: astaxanthin; comprehensive gene expression analysis; eukaryotic initiation factor-2 (EIF2); nonalcoholic steatohepatitis (NASH); peroxisome proliferator-activated receptor α (PPARA); vitamin E