title: The follicle-stimulating hormone receptor Asn680Ser polymorphism is associated with preterm birth in Hispanic women.
abstract: OBJECTIVE
  Recently, a study based on the analysis of accelerated evolution of related genes at birth identified the follicle-stimulating hormone receptor (FSHR) as a possible candidate for the development of preterm delivery. Additionally, FSHR expression has been described in extragonadal tissue including the placenta. Therefore, the aim of the present study was to determine the association between the N680S polymorphism of the follicle-stimulating hormone receptor and preterm birth in a population of Hispanic women.
  
  
  METHODS
  Placenta samples were obtained from 64 women who had preterm births and 54 control cases. DNA was extracted and genotyped for the N680S FSHR gene polymorphism by polymerase chain reaction-restriction fragment length polymorphism. The χ2test and t-test were used to calculate statistical significance.
  
  
  RESULTS
  Statistically significant differences in genotype frequencies for the N680S polymorphism were observed between preterm and term groups (p = .04). Based on the Akaike information criterion values, the dominant model showed that the NN genotype had a significantly increased risk of preterm birth compared with the SS + NS genotype (OR 2.52, 95% CI 1.20-5.33, p = .02).
  
  
  CONCLUSIONS
  The results herein suggest that the FSHR polymorphism N680S is significantly associated with preterm birth in the Hispanic population.
authors.affiliation: a Unidad de Investigacion Medica en Medicina Reproductiva, UMAE Hospital de Gineco Obstetricia No. 4 Luis Castelazo Ayala, Instituto Mexicano del Seguro Social , Ciudad de Mexico , Mexico.
authors.forename: Pablo
authors.initials: P
authors.lastname: Dominguez-Lopez
authors.affiliation: a Unidad de Investigacion Medica en Medicina Reproductiva, UMAE Hospital de Gineco Obstetricia No. 4 Luis Castelazo Ayala, Instituto Mexicano del Seguro Social , Ciudad de Mexico , Mexico.
authors.forename: Laura
authors.initials: L
authors.lastname: Diaz-Cueto
authors.affiliation: b Centro Nacional de Investigacion Disciplinaria en Fisiologia y Mejoramiento Animal, Instituto Nacional de Investigaciones Forestales, Agricolas y Pecuarias , Queretaro , Mexico.
authors.forename: Miguel
authors.initials: M
authors.lastname: Arechavaleta-Velasco
authors.affiliation: c Division de Obstetricia , UMAE Hospital de Gineco Obstetricia No. 4 Luis Castelazo Ayala, Instituto Mexicano del Seguro Social , Ciudad de Mexico , Mexico.
authors.forename: Felipe
authors.initials: F
authors.lastname: Caldiño-Soto
authors.affiliation: d Red de Apoyo a la Investigacion (RAI), Universidad Nacional Autonoma de Mexico-Instituto Nacional de Ciencias Medicas y Nutricion SZ , Ciudad de Mexico , Mexico.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ulloa-Aguirre
authors.affiliation: a Unidad de Investigacion Medica en Medicina Reproductiva, UMAE Hospital de Gineco Obstetricia No. 4 Luis Castelazo Ayala, Instituto Mexicano del Seguro Social , Ciudad de Mexico , Mexico.
authors.forename: Fabian
authors.identifier: http://orcid.org/0000-0002-6814-1235
authors.initials: F
authors.lastname: Arechavaleta-Velasco
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D007197:Indians, Central American / Q000235:genetics*; D008800:Mexico; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics*; D011962:Receptors, FSH / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D011962:Receptors, FSH
keywords: Follicle-stimulating hormone receptor; Hispanic population; preterm birth; single nucleotide polymorphism