title: Three-Component Asymmetric Mannich Reaction Catalyzed by a Lewis Acid with Rhodium-Centered Chirality.
abstract: A highly efficient direct asymmetric three-component Mannich reaction of an N-acylpyrazole, an aldehyde and a primary or secondary amine, was enabled by a rhodium-based Lewis-acid catalyst with metal-centered chirality. Excellent enantioselectivities were achieved for a variety of substrates at a typical catalyst loading of merely 0.5 mol % (23 examples, up to 98 % ee).
authors.affiliation: Fujian Provincial Key Laboratory of Chemical Biology, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, People's Republic of China.
authors.forename: Lihe
authors.initials: L
authors.lastname: Feng
authors.affiliation: Fujian Provincial Key Laboratory of Chemical Biology, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, People's Republic of China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Dai
authors.affiliation: Fujian Provincial Key Laboratory of Chemical Biology, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, People's Republic of China.|Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße 4, 35043, Marburg, Germany.
authors.forename: Eric
authors.initials: E
authors.lastname: Meggers
authors.affiliation: Fujian Provincial Key Laboratory of Chemical Biology, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, People's Republic of China.
authors.forename: Lei
authors.identifier: http://orcid.org/0000-0002-4478-6880
authors.initials: L
authors.lastname: Gong
keywords: Lewis acids; Mannich reaction; metal-centered chirality; multicomponent reactions; rhodium