title: Concomitant confluent and reticulated papillomatosis and acanthosis nigricans in an obese girl with insulin resistance successfully treated with oral minocycline: Case report and published work review.
abstract: Concomitant confluent and reticulated papillomatosis (CRP) and acanthosis nigricans (AN) is rare. We present a case of concomitant CRP and obesity-associated AN in a 12-year-old obese Japanese girl. Curiously, oral minocycline therapy, which has been shown to be effective for CRP, was effective against both CRP and AN. Possible mechanisms by which minocycline could have improved skin lesions of CRP and obesity-associated AN are discussed. In addition, reports of concomitant CRP and obesity-associated AN are reviewed. CRP and obesity-associated AN share common clinicopathological features and some reports have described concomitant CRP and obesity-associated AN. Together with the observation that skin lesions of CRP and obesity-associated AN in the present case responded to oral minocycline therapy, these facts suggest a tight relationship or a common pathogenetic pathway between these pathologies.
authors.affiliation: Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fukumoto
authors.affiliation: Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kozaru
authors.affiliation: Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.|Division of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Sakaguchi
authors.affiliation: Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.|Division of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Oka
mesh_terms: D000052:Acanthosis Nigricans / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D000469:Alkaline Phosphatase / Q000097:blood; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D002648:Child; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008911:Minocycline / Q000627:therapeutic use; D009765:Obesity / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D010212:Papilloma / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D035583:Rare Diseases / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D002096:C-Peptide; D000469:Alkaline Phosphatase; D008911:Minocycline
keywords: acanthosis nigricans; confluent and reticulated papillomatosis; insulin resistance; minocycline; obesity