title: [Primary large cell neuroendocrine carcinoma of the breast: a rare tumor in humans].
abstract: Primitive large cell neuroendocrine tumor of the breast is an extremely rare entity. Less than ten cases have been reported in the literature. We report a new case of a 61-year old male patient presenting with locally advanced tumor of the right breast, immediately metastasized to the lungs and pleura, staged cT4bN1M1. The patient received eight cycles of Docetaxel-based chemotherapy every 21 days, with a good clinical and radiological response (>50%), followed by adjuvant tamoxifen with disease stabilization for 18 months. Immunohistochemistry is still essential to determine the neuroendocrine nature of this tumor. Treatment is not well codified due to the rarity of this type of cancer.
authors.affiliation: Service d'Oncologie et de Radiothérapie, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: Fatima
authors.initials: F
authors.lastname: Safini
authors.affiliation: Service d'Oncologie et de Radiothérapie, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: Zineb
authors.initials: Z
authors.lastname: Bouchbika
authors.affiliation: Service d'Oncologie et de Radiothérapie, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: Zineb
authors.initials: Z
authors.lastname: Bennani
authors.affiliation: Service d'Oncologie et de Radiothérapie, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: Sara
authors.initials: S
authors.lastname: Belkheiri
authors.affiliation: Laboratoire d'Etude Anatomopathologique Moulay Driss Premier, Casablanca, Maroc.
authors.forename: Hicham El
authors.initials: HE
authors.lastname: Attar
authors.affiliation: Service d'Oncologie et de Radiothérapie, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: Nadia
authors.initials: N
authors.lastname: Benchakroun
authors.affiliation: Service d'Oncologie et de Radiothérapie, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: Hassan
authors.initials: H
authors.lastname: Jouhadi
authors.affiliation: Service d'Oncologie et de Radiothérapie, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: Nezha
authors.initials: N
authors.lastname: Tawfiq
authors.affiliation: Service d'Oncologie et de Radiothérapie, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: Souha
authors.initials: S
authors.lastname: Sahraoui
authors.affiliation: Service d'Oncologie et de Radiothérapie, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: Abdellatif
authors.initials: A
authors.lastname: Benider
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D018567:Breast Neoplasms, Male / Q000188:drug therapy / Q000473:pathology*; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy / Q000473:pathology*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D000077143:Docetaxel; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary; D013629:Tamoxifen / Q000008:administration & dosage; D043823:Taxoids / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D013629:Tamoxifen; D000077143:Docetaxel
keywords: Breast cancer; large cells; neuroendocrine