title: Vancomycin-associated linear IgA disease mimicking toxic epidermal necrolysis.
abstract: Linear IgA dermatosis is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. In the last three decades, many different drugs have been associated with the drug-induced form of the disease, especially vancomycin. We report a case of vancomycin-induced linear IgA disease mimicking toxic epidermal necrolysis. The aim of this work is to emphasize the need to include this differential diagnosis in cases of epidermal detachment and to review the literature on the subject and this specific clinical presentation.
authors.affiliation: Universidade Federal de São Paulo (Unifesp) - São Paulo (SP), Brazil.
authors.forename: Amanda Regio
authors.initials: AR
authors.lastname: Pereira
authors.affiliation: Universidade Federal de São Paulo (Unifesp) - São Paulo (SP), Brazil.
authors.forename: Luis Henrique Barbizan de
authors.initials: LH
authors.lastname: Moura
authors.affiliation: Universidade Federal de São Paulo (Unifesp) - São Paulo (SP), Brazil.
authors.forename: Jhonatan Rafael Siqueira
authors.initials: JR
authors.lastname: Pinheiro
authors.affiliation: Universidade Federal de São Paulo (Unifesp) - São Paulo (SP), Brazil.
authors.forename: Victor Pavan
authors.initials: VP
authors.lastname: Pasin
authors.affiliation: Universidade Federal de São Paulo (Unifesp) - São Paulo (SP), Brazil.
authors.forename: Milvia Maria Simões E Silva
authors.initials: MM
authors.lastname: Enokihara
authors.affiliation: Universidade Federal de São Paulo (Unifesp) - São Paulo (SP), Brazil.
authors.forename: Adriana Maria
authors.initials: AM
authors.lastname: Porro
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001706:Biopsy; D003937:Diagnosis, Differential; D004817:Epidermis / Q000473:pathology; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D062027:Linear IgA Bullous Dermatosis / Q000139:chemically induced* / Q000473:pathology*; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000473:pathology*; D014640:Vancomycin / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin