title: Metal-Free Intermolecular Aminoarylation of Alkynes.
abstract: A metal-free aminoarylation of internal alkynes is described, yielding tetrasubstituted enaminoates. The transformation proceeds in good to excellent yields through a tandem conjugate addition/Smiles rearrangement involving aryl and heteroaryl sulfonamides. Substrate scope is very broad under simple, user-friendly conditions, and the reaction can be used to easily access biologically active phenethylamine derivatives.
authors.affiliation: School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Pauline T G
authors.initials: PT
authors.lastname: Rabet
authors.affiliation: Department of Oncology, AstraZeneca, Darwin Building, Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK.
authors.forename: Scott
authors.initials: S
authors.lastname: Boyd
authors.affiliation: School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Michael F
authors.identifier: 0000-0001-9633-1135
authors.initials: MF
authors.lastname: Greaney
keywords: alkynes; aminoarylation; difunctionalization; rearrangments; sulfonamides