title: Interleukin-12B gene polymorphisms and bronchial asthma risk: A meta-analysis.
abstract: OBJECTIVE
  This meta-analysis aims to investigate whether interleukin-12B (IL-12B) -1188A/C or the promoter polymorphisms may be a risk factor for asthma.
  
  
  METHODS
  Web of Science, PubMed, China National Knowledge Infrastructure (CNKI) and Wanfang databases were searched (updated August 20, 2015).
  
  
  METHODS
  Articles evaluating the association between IL-12B genetic polymorphisms and asthma risk were selected.
  
  
  RESULTS
  13 eligible studies with a total of 5092 subjects were finally included in this meta-analysis. For IL-12B -1188A/C, analysis by ethnicity indicated that there was a markedly reduced risk for asthma in East Asian (CC + AC vs. AA: OR = 0.64, 95% CI = 0.50-0.81, P < 0.001). For IL-12B promoter, analysis by ethnicity indicated there was a markedly increased risk in East Asian (MM vs. WM + WW: OR = 1.57, 95% CI = 1.18-2.10, P = 0.002). Analysis by allergic state revealed the similar results in atopic subgroup.
  
  
  CONCLUSIONS
  IL-12B -1188 C allele may be a protective factor against asthma in East Asian. In addition, promoter MM genotype may be a risk factor for asthma in East Asian and allergic people.
authors.affiliation: a Department of Respiratory Medicine , the First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
authors.forename: Fangwei
authors.initials: F
authors.lastname: Li
authors.affiliation: a Department of Respiratory Medicine , the First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
authors.forename: Yanting
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: a Department of Respiratory Medicine , the First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
authors.forename: Xinming
authors.initials: X
authors.lastname: Xie
authors.affiliation: a Department of Respiratory Medicine , the First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
authors.forename: Rui
authors.initials: R
authors.lastname: Ke
authors.affiliation: a Department of Respiratory Medicine , the First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Li
authors.affiliation: a Department of Respiratory Medicine , the First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: b Department of Clinical Research Center , the First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.affiliation: a Department of Respiratory Medicine , the First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
authors.forename: Manxiang
authors.initials: M
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000235:genetics*; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D053762:Interleukin-12 Subunit p40 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D053762:Interleukin-12 Subunit p40
keywords: Asthma; IL-12B; genetic; meta-analysis; polymorphisms