title: Teduglutide for treatment of adult patients with short bowel syndrome.
abstract: The European Society for Clinical Nutrition has published recommendations on the 'definition and classification of intestinal failure (IF)'. Two criteria must be present: a 'decreased absorption of macronutrients and/or water and electrolytes due to a loss of gut function' and the 'need for parenteral support'. Home parenteral support (HPS) is the primary treatment for chronic IF but is associated with complications. Areas covered: The principal cause of chronic IF is short bowel syndrome (SBS). The aim of treatment is to maximize intestinal absorption and reduce or eliminate the need for HPS to achieve the best possible quality of life. Teduglutide, an analog of glucagon-like peptide 2, improves intestinal rehabilitation by promoting mucosal growth, reducing intestinal loss and promoting intestinal absorption. This article provides an overview and opinion on teduglutide for SBS. Expert opinion: Teduglutide may provide a new treatment strategy for SBS patients with chronic IF. When prescribed, patients should be informed of the benefits and risks of the drug and must be closely monitored in an expert center. Furthermore, as this treatment is costly, cost-effectiveness analysis as well as the risk-benefit ratio needs to be better evaluated.
authors.affiliation: a Hopital Beaujon - Department of Gastroenterology and Nutrition Support , APHP - University Paris VII , Clichy , France.
authors.forename: Lore
authors.initials: L
authors.lastname: Billiauws
authors.affiliation: b Hopital Beaujon - Department of Pharmacy , APHP - University Paris VII , Clichy , France.
authors.forename: Julie
authors.initials: J
authors.lastname: Bataille
authors.affiliation: a Hopital Beaujon - Department of Gastroenterology and Nutrition Support , APHP - University Paris VII , Clichy , France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Boehm
authors.affiliation: a Hopital Beaujon - Department of Gastroenterology and Nutrition Support , APHP - University Paris VII , Clichy , France.|c Laboratory for Vascular Translational Science , UFR de Médecine Paris Diderot , Paris , France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Corcos
authors.affiliation: a Hopital Beaujon - Department of Gastroenterology and Nutrition Support , APHP - University Paris VII , Clichy , France.|d Centre de Recherche sur l'Inflammation , Gastrointestinal and Metabolic Dysfunctions in Nutritional Pathologies , Paris , France.
authors.forename: Francisca
authors.initials: F
authors.lastname: Joly
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic / Q000379:methods; D003362:Cost-Benefit Analysis; D053767:Glucagon-Like Peptide 2 / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D010288:Parenteral Nutrition / Q000379:methods; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use*; D011788:Quality of Life; D018570:Risk Assessment; D012778:Short Bowel Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D053767:Glucagon-Like Peptide 2; D010455:Peptides; C494910:teduglutide
keywords: Teduglutide; glucagon-like peptide-2; short bowel syndrome; total parenteral nutrition