title: Patient non adherence to tuberculosis treatment in Sudan: socio demographic factors influencing non adherence to tuberculosis therapy in Khartoum State.
abstract: BACKGROUND
  Despite the Treatment pulmonary TB patients, defaulting from treatment may remain the major challenge to control TB. In addition, it increases the risk of drug resistance, relapse, and death and may prolong infectiousness. Our objective was to identify determinants of treatment defaulting among TB patients in Khartoum State, Sudan.
  
  
  METHODS
  We conducted a case-control study where the patients defaulting from treatment were considered as 'cases' and those completing treatment as 'controls'. Between May 2010 to May 2011.
  
  
  RESULTS
  There were 2727 TB patients who attended TB treatment clinics during study period. Out of these 2399 patients (86%) had continued their treatment while 328 patients (14%) had interrupted it. 105 cases were traced and interviewed. In addition 210 patients who had continued their treatment were included (controls). In the multivariate analysis the variables that remained in the model were: residential locality (rural area) (OR 2.58; 95% CI 1.4 -4.67), patients moving or changing address (OR 5.47; 95% CI 2,90- 10-35), absence of family support (OR 2.14; 95% CI 1.12 - 4.11), and occupation (blue collar work) (OR 2.38; 95% CI 1.39 -4.10).
  
  
  CONCLUSIONS
  The results of this study conclude some socio-demographic factors influence defaulting of TB treatment. We believe that the findings are applicable to current situation of TB management and control in Sudan and other developing countries.
authors.affiliation: Ministry of Health, Saudi Arabia, Maastricht University Medical Centre, Maastricht, the Netherlands.
authors.forename: Ahmed Osman Ahmed
authors.initials: AO
authors.lastname: Ali
authors.affiliation: Maastricht University Medical Centre, Maastricht, the Netherlands.
authors.forename: Martinus Hendrik
authors.initials: MH
authors.lastname: Prins
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016022:Case-Control Studies; D003906:Developing Countries; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009790:Occupations / Q000706:statistics & numerical data; D012111:Residence Characteristics / Q000706:statistics & numerical data; D012944:Social Support; D013397:Sudan; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D055815:Young Adult; D016903:Drug Monitoring
chemical_list: D000995:Antitubercular Agents
keywords: Tuberculosis; adherence; compliance; defaulter; non-adherence