title: A retrospective study of ultrasound and FNA cytology investigation of thyroid nodules: working towards combined risk stratification.
abstract: The British Thyroid Association recommended in new guidelines on thyroid cancer treatment [Kwak et al. (Korean J Radiol 14:110-117, 2013)] that ultrasound grading of thyroid nodules should be incorporated into MDT management. A retrospective study was carried out to determine that the impact of US grading has had on MDT decision making in practice. The design used in the study is a retrospective review of case notes. The study was carried out in the hub hospital for thyroid cancer in the North west London Cancer network. We included consecutive patients referred to the regional thyroid multidisciplinary meeting between August 2014 and May 2015 for investigation of thyroid nodules. Data were collected on patient demographics, co-morbidity, thy grading, ultrasound grading, surgery, post-operative histology, and radioactive iodine treatment details. Accuracy of cytology and ultrasound in diagnosing malignancy was correlated to definitive histology. 99 patients with thyroid nodules were included in the study. 97% of patients had at least one fine needle aspiration and 75% had ultrasound grading. Thy3f (Bethesda IV) nodules were more likely to be carcinoma if associated with a U4 grade rather than U3 (67 vs 18%, p = 0.028). Ultrasound grading has recently been introduced to the standard practice in investigation of thyroid nodules. Further assessment of the accuracy of ultrasound grading in clinical practice may allow us to risk-stratify thy3a/thy3f (Bethesda III/IV) lesions and personalise treatment.
authors.affiliation: Northwick Park Hospital, Watford Rd, Harrow, HA1 3UJ, UK. zwl20cam@gmail.com.
authors.forename: Zi Wei
authors.identifier: http://orcid.org/0000-0002-6043-3444
authors.initials: ZW
authors.lastname: Liu
authors.affiliation: Northwick Park Hospital, Watford Rd, Harrow, HA1 3UJ, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Fox
authors.affiliation: Northwick Park Hospital, Watford Rd, Harrow, HA1 3UJ, UK.
authors.forename: Samit
authors.initials: S
authors.lastname: Unadkat
authors.affiliation: Northwick Park Hospital, Watford Rd, Harrow, HA1 3UJ, UK.
authors.forename: Roy
authors.initials: R
authors.lastname: Farrell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D003657:Decision Making; D006801:Humans; D008131:London; D008875:Middle Aged; D011184:Postoperative Period; D012189:Retrospective Studies; D018570:Risk Assessment; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D016606:Thyroid Nodule / Q000000981:diagnostic imaging* / Q000473:pathology; D014463:Ultrasonography
keywords: Fine needle cytology; Thyroid cancer; Thyroid surgery