title: Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways.
abstract: Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids between the different compartments of eukaryotic cells. They act by recruiting and/or activating effector proteins and thus are involved in regulating various cellular functions, such as vesicular budding, membrane fusion and cytoskeleton dynamics. Although detected in small concentrations in membranes, their role is essential to cell function, since imbalance in their concentrations is a hallmark of many cancers. Their synthesis involves phosphorylating/dephosphorylating positions D3, D4 and/or D5 of their inositol ring by specific lipid kinases and phosphatases. This process is tightly regulated and specific to the different intracellular membranes. Most enzymes involved in phosphoinositide synthesis are conserved between yeast and human, and their loss of function leads to severe diseases (cancer, myopathy, neuropathy and ciliopathy).
authors.affiliation: Department of Molecular and Cellular Genetics, Université de Strasbourg, CNRS, GMGM UMR 7156, F-67000 Strasbourg, France. johan-owen.decraene@univ-tours.fr.
authors.forename: Johan-Owen
authors.initials: JO
authors.lastname: De Craene
authors.affiliation: Department of Molecular and Cellular Genetics, Université de Strasbourg, CNRS, GMGM UMR 7156, F-67000 Strasbourg, France. dimitri.bertazzi@gmail.com.
authors.forename: Dimitri L
authors.initials: DL
authors.lastname: Bertazzi
authors.affiliation: Department of Molecular and Cellular Genetics, Université de Strasbourg, CNRS, GMGM UMR 7156, F-67000 Strasbourg, France. sbar@unistra.fr.
authors.forename: Séverine
authors.initials: S
authors.lastname: Bär
authors.affiliation: Department of Molecular and Cellular Genetics, Université de Strasbourg, CNRS, GMGM UMR 7156, F-67000 Strasbourg, France. s.friant@unistra.fr.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Friant
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D001343:Autophagy; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008247:Lysosomes / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D015398:Signal Transduction; D013261:Sterols / Q000378:metabolism
chemical_list: D000199:Actins; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D010743:Phospholipids; D013261:Sterols; C055525:phosphatidylinositol 3-phosphate; C037178:phosphatidylinositol 4-phosphate; C113567:phosphatidylinositol 5-phosphate
keywords: kinase; lipids; membrane trafficking; phosphatase; phosphoinositides; vesicles