title: Comparison of half-dose photodynamic therapy and 689 nm laser treatment in eyes with chronic central serous chorioretinopathy.
abstract: OBJECTIVE
  To compare visual and anatomical outcomes between half-dose photodynamic therapy (hd-PDT) and 689 nm laser therapy (689-LT) in chronic central serous chorioretinopathy (CSC).
  
  
  METHODS
  Forty eyes of 40 patients with symptomatic chronic CSC were randomized in a 1:1 ratio to receive either hd-PDT or 689-LT delivering 95 J/cm2via an intensity application of 805 mW/cm2over 118 s. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography findings were compared between the two treatment groups.
  
  
  RESULTS
  Mean CSC duration was 17.1 ± 6.66 weeks and 18.7 ± 7.46 weeks in the hd-PDT and 689-LT groups respectively. Both groups showed significant BCVA improvements, as well as reductions in central retinal and subfoveal choroidal thickness. Although hd-PDT led to a faster reduction in central retinal thickness, no significant differences were recorded between groups for any other measured parameter at any time point. Complete photoreceptor recovery was observed in eight and seven eyes in the hd-PDT and 689-LT groups respectively.
  
  
  CONCLUSIONS
  Both hd-PDT and 689-LT were effective at treating chronic CSC. Further studies are warranted to evaluate long-term safety and efficacy.
authors.affiliation: Eye Clinic, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazzale Spedale Civili, 1, 25100, Brescia, Italy. dott.andrea.russo@me.com.
authors.forename: Andrea
authors.identifier: http://orcid.org/0000-0002-1566-3662
authors.initials: A
authors.lastname: Russo
authors.affiliation: Eye Clinic, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazzale Spedale Civili, 1, 25100, Brescia, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Turano
authors.affiliation: Eye Clinic, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazzale Spedale Civili, 1, 25100, Brescia, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Morescalchi
authors.affiliation: Eye Clinic, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazzale Spedale Civili, 1, 25100, Brescia, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Gambicorti
authors.affiliation: Eye Clinic, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazzale Spedale Civili, 1, 25100, Brescia, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Cancarini
authors.affiliation: Eye Clinic, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazzale Spedale Civili, 1, 25100, Brescia, Italy.
authors.forename: Sarah
authors.initials: S
authors.lastname: Duse
authors.affiliation: Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
authors.forename: Ciro
authors.initials: C
authors.lastname: Costagliola
authors.affiliation: Eye Clinic, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazzale Spedale Civili, 1, 25100, Brescia, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Semeraro
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000188:drug therapy*; D002829:Choroid / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000473:pathology; D005654:Fundus Oculi; D006801:Humans; D007262:Infusions, Intravenous; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D010865:Pilot Projects; D011166:Porphyrins / Q000008:administration & dosage*; D011446:Prospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D000077362:Verteporfin; D014792:Visual Acuity
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin
keywords: Central serous chorioretinopathy; Laser treatment; Photodynamic therapy; Subthreshold micropulse laser