title: MnO2-Based Nanoplatform Serves as Drug Vehicle and MRI Contrast Agent for Cancer Theranostics.
abstract: Multidrug resistance (MDR) greatly impedes the therapeutic efficacy of chemotherapeutic agents. Overexpression of ATP-binding cassette (ABC) transporters, such as P-gp, on the surface of tumor cells is a major mechanism in MDR. In this study, we fabricated manganese dioxide (MnO2)/doxorubicin (DOX)-loaded albumin nanoparticles (BMDN) for magnetic resonance imaging and reversing MDR in resistant tumor. BMDN facilitated the delivery of DOX into MDR tumor cells through their MDR reversal effects including enhanced cellular uptake, reduced drug efflux, and decreased hypoxic tumor microenvironment. BMDN also acted as an effective MRI contrast agent, thereby causing good in vitro and in vivo T1-weighted imaging.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Xing
authors.forename: Hengte
authors.initials: H
authors.lastname: Ke
authors.forename: Yu-Jing
authors.initials: YJ
authors.lastname: He
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Cui
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: College of Life Sciences and Biotechnology, Dalian University , Dalian, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Jiang
authors.forename: Jian-Bin
authors.initials: JB
authors.lastname: Qiao
authors.forename: Na
authors.initials: N
authors.lastname: Lu
authors.forename: Huabing
authors.identifier: http://orcid.org/0000-0003-1637-2872
authors.initials: H
authors.lastname: Chen
authors.forename: Hu-Lin
authors.initials: HL
authors.lastname: Jiang
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry*; D004317:Doxorubicin; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008279:Magnetic Resonance Imaging; D017895:Manganese Compounds; D010087:Oxides; D000068936:Theranostic Nanomedicine
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D003287:Contrast Media; D017895:Manganese Compounds; D010087:Oxides; D004317:Doxorubicin; C016552:manganese dioxide
keywords: doxorubicin; manganese dioxide; multidrug resistance; multifunction nanoparticles; theranostics