title: Early-Stage Gastric Cancer Can Be Found in Improved Atrophic Mucosa over Time from Successful Helicobacter pylori Eradication.
abstract: OBJECTIVE
  Early-stage gastric cancer (EGC) is detected even after successful Helicobacter pylori eradication. This study is aimed at clarifying the clinicopathological characteristics of EGC detected after successful H. pylori eradication.
  
  
  METHODS
  This retrospective study analyzed 57 cases of EGC detected after successful H. pylori eradication and resected endoscopically at Kyoto Prefectural University of Medicine, between January 2009 and June 2014. Clinicopathological findings of 57 cases (H. pylori-eradicated group) were investigated, and compared with those in active H. pylori infection resected in the same period (H. pylori-positive group).
  
  
  RESULTS
  Most EGCs were detected in patients with severe atrophic mucosa, both in H. pylori-eradicated and H. pylori-positive groups, while the percentage of EGC detected in patients with mild atrophic mucosa gradually increased over time from successful eradication (H. pylori-positive: 7%, up to the fourth year since eradication: 11%, after the fifth year since eradication: 32%). The percentage of EGC detected in patients with mild atrophic mucosa after the fifth year since eradication was significantly higher than that in patients with active H. pylori infection (p = 0.004).
  
  
  CONCLUSIONS
  After the fifth year following eradication, we should be alert to the incidence of EGC, irrespective of the severity of mucosal atrophic change.
authors.affiliation: Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Majima
authors.forename: Osamu
authors.initials: O
authors.lastname: Handa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
authors.forename: Osamu
authors.initials: O
authors.lastname: Dohi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Okayama
authors.forename: Naohisa
authors.initials: N
authors.lastname: Yoshida
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kamada
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Katada
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Uchiyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Takagi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Konishi
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Yagi
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Itoh
mesh_terms: D000367:Age Factors; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000069916:Endoscopic Mucosal Resection; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D007564:Japan; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology* / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents
keywords: Detection; Early-stage gastric cancer; Eradication; Helicobacter pylori; Mucosal atrophy