title: Treatment of metastatic melanoma: a multidisciplinary approach.
abstract: The prognosis of stage IV metastatic melanoma is poor. An overall 1-year survival of 25.5% and a median survival of 6.2 months were reported without any significant improvement during the last 30 years before the introduction of new drugs (immune checkpoint inhibitors and targeted therapies) which completely modified the therapeutic approach and induced an overwhelming improvement on the survival rates of these patients. This review will analyze the therapeutic tools available for the treatment of patients with metastatic melanoma, including adjuvant interferon and locoregional therapies (surgery, radiotherapy and electrochemotherapy) and will mainly focus on the presentation of results obtained by the new treatments (checkpoint inhibitors and targeted therapies).
authors.affiliation: Clinic of Dermatology, Department of Medical Sciences, School of Medicine, University of Turin, Turin, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fava
authors.affiliation: Clinic of Dermatology, Department of Medical Sciences, School of Medicine, University of Turin, Turin, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Astrua
authors.affiliation: Clinic of Dermatology, Department of Medical Sciences, School of Medicine, University of Turin, Turin, Italy.|Department of Dermatology, Mt. Zion Cancer Research Center, University of California, San Francisco, CA, USA.
authors.forename: Martina
authors.initials: M
authors.lastname: Sanlorenzo
authors.affiliation: Clinic of Dermatology, Department of Medical Sciences, School of Medicine, University of Turin, Turin, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Ribero
authors.affiliation: Clinic of Dermatology, Department of Medical Sciences, School of Medicine, University of Turin, Turin, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Brizio
authors.affiliation: Department of Oncology, University of Turin, Turin, Italy.|Radiation Oncology Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
authors.forename: Andrea R
authors.initials: AR
authors.lastname: Filippi
authors.affiliation: Clinic of Dermatology, Department of Medical Sciences, School of Medicine, University of Turin, Turin, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Marra
authors.affiliation: Section of Surgical Dermatology, AOU Città della Salute e della Scienza, Turin, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Picciotto
authors.affiliation: Medical Oncology Unit, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Turin, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Sangiolo
authors.affiliation: Medical Oncology Unit, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Turin, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Carnevale-Schianca
authors.affiliation: Department of Oncology, University of Turin, Turin, Italy.|Medical Oncology Unit, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Turin, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Aglietta
authors.affiliation: Sarcoma Unit, Department of Surgery, University of Turin, Turin, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Sandrucci
authors.affiliation: Department of Oncology, University of Turin, Turin, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Ricardi
authors.affiliation: Section of Surgical Dermatology, AOU Città della Salute e della Scienza, Turin, Italy.
authors.forename: Virginia
authors.initials: V
authors.lastname: Caliendo
authors.affiliation: Clinic of Dermatology, Department of Medical Sciences, School of Medicine, University of Turin, Turin, Italy - pietro.quaglino@unito.it.
authors.forename: Pietro
authors.initials: P
authors.lastname: Quaglino
authors.affiliation: Clinic of Dermatology, Department of Medical Sciences, School of Medicine, University of Turin, Turin, Italy.
authors.forename: Maria T
authors.initials: MT
authors.lastname: Fierro
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D008545:Melanoma / Q000556:secondary* / Q000628:therapy*; D010348:Patient Care Team; D012878:Skin Neoplasms / Q000473:pathology*