title: Effects of Hyperlipidemia and Cardiovascular Diseases on Proliferation, Differentiation and Homing of Mesenchymal Stem Cells.
abstract: BACKGROUND
  Various clinical studies have revealed that cardiovascular diseases (CVD) are associated with bone loss diseases such as osteoporosis and periodontitis, especially in older population. As one of the best-established risk factors of CVD, hyperlipidemia is also reported to interfere with the metabolism, function and regeneration of mineralized tissues. Derived from postnatal tissue reservoirs, mesenchymal stem cells (MSCs) are considered promising cell sources for mesenchymal and non-mesenchymal tissue regeneration based on their capacities for self-renewal and multi-lineage differentiation as well as potent immunosuppressive effects, secretion of cytokines and regulation of vascularization. MSCs could home to the injury sites from peripheral circulation, proliferate and differentiate into bone-forming cells, therefore significantly enhancing bone regeneration. However, elevated blood lipid levels affect the physiological behaviors of MSCs, as well as the performance of transplanted MSCs.
  
  
  OBJECTIVE
  This review aims to summarize the effects of hyperlipidemia and CVD on the proliferation, osteogenic differentiation and homing of MSCs. The principal observations of the underlying cellular and molecular mechanisms as well as the effects of lipid-lowering therapy on MSCs are also discussed.
authors.affiliation: School of Stomatology, Shandong University, Jinan, Shandong 250012, China.|Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Shandong University, Jinan, Shandong 250012, China.|Endodontics, Comprehensive Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ye
authors.affiliation: Endodontics, Comprehensive Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
authors.forename: Chengfei
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D006949:Hyperlipidemias / Q000503:physiopathology*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D010012:Osteogenesis
keywords: Cardiovascular diseases; homing; hyperlipidemia; mesenchymal stem cells; osteogenic differentiation; proliferation