title: Temporal Evaluation of Polybrominated Diphenyl Ether (PBDE) Serum Levels in Middle-Aged and Older California Women, 2011-2015.
abstract: In response to health concerns and widespread human exposures, two widely used commercial formulations of polybrominated diphenyl ethers (PBDEs) were banned in the United States in 2005. Initial biomonitoring data have provided early indications of reduced human exposures since these bans took effect. Our objective was to evaluate temporal trends in PBDE serum levels among a population of older California women during a four-year period, beginning approximately five years after these formulations were banned. Automated solid phase extraction and gas chromatography/high resolution mass spectrometry were used to measure PBDE levels in blood collected during 2011-2015 among 1253 women (ages 40-94) participating in the California Teachers Study. Only congeners with detection frequencies (DF) ≥ 75% were included in the present analysis: BDE-47 (DF = 88%); BDE-100 (DF = 78%); and BDE-153 (DF = 80%). Results from age- and race/ethnicity-adjusted linear regression analyses indicated modest, but statistically significant, average annual percent increases in the serum concentrations of all three PBDEs over the four-year study period. While not without limitations, these results, in the context of other biomonitoring data, suggest that earlier reported declines in PBDE levels may have plateaued and may now be starting to increase. Further biomonitoring to ascertain current trends and determinants of population exposures is warranted.
authors.affiliation: Cancer Prevention Institute of California , Berkeley, California 94704, United States.
authors.forename: Susan
authors.identifier: 0000-0002-5582-1741
authors.initials: S
authors.lastname: Hurley
authors.affiliation: Cancer Prevention Institute of California , Berkeley, California 94704, United States.
authors.forename: Debbie
authors.initials: D
authors.lastname: Goldberg
authors.affiliation: Cancer Prevention Institute of California , Berkeley, California 94704, United States.
authors.forename: David O
authors.initials: DO
authors.lastname: Nelson
authors.affiliation: Environmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, California 95812, United States.|Food and Drug Laboratory Branch, California Department of Public Health, Richmond, California 94804, United States.
authors.forename: Weihong
authors.initials: W
authors.lastname: Guo
authors.affiliation: Environmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, California 95812, United States.
authors.forename: Yunzhu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Environmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, California 95812, United States.
authors.forename: Hyoung-Gee
authors.initials: HG
authors.lastname: Baek
authors.affiliation: Environmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, California 95812, United States.
authors.forename: June-Soo
authors.initials: JS
authors.lastname: Park
authors.affiliation: Environmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, California 95812, United States.
authors.forename: Myrto
authors.initials: M
authors.lastname: Petreas
authors.affiliation: Department of Population Sciences, Beckman Research Institute of the City of Hope , Duarte, California 91010, United States.
authors.forename: Leslie
authors.initials: L
authors.lastname: Bernstein
authors.affiliation: Department of Epidemiology, School of Medicine, University of California Irvine , Irvine, California 92697, United States.
authors.forename: Hoda
authors.initials: H
authors.lastname: Anton-Culver
authors.affiliation: Cancer Prevention Institute of California , Berkeley, California 94704, United States.|Stanford University School of Medicine , Department of Health Research and Policy, Stanford, California 94305, United States.
authors.forename: Peggy
authors.initials: P
authors.lastname: Reynolds
mesh_terms: D000368:Aged; D002140:California; D004784:Environmental Monitoring; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D055768:Halogenated Diphenyl Ethers / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D011075:Polybrominated Biphenyls / Q000097:blood*; D052616:Solid Phase Extraction
chemical_list: D055768:Halogenated Diphenyl Ethers; D011075:Polybrominated Biphenyls