title: Cannabidiol Affects MK-801-Induced Changes in the PPI Learned Response of Capuchin Monkeys (Sapajusspp.).
abstract: There are several lines of evidence indicating a possible therapeutic action of cannabidiol (CBD) in schizophrenia treatment. Studies with rodents have demonstrated that CBD reverses MK-801 effects in prepulse inhibition (PPI) disruption, which may indicate that CBD acts by improving sensorimotor gating deficits. In the present study, we investigated the effects of CBD on a PPI learned response of capuchin monkeys (Sapajusspp.). A total of seven monkeys were employed in this study. In Experiment 1, we evaluated the CBD (doses of 15, 30, 60 mg/kg, i.p.) effects on PPI. In Experiment 2, the effects of sub-chronic MK-801 (0.02 mg/kg, i.m.) on PPI were challenged by a CBD pre-treatment. No changes in PPI response were observed after CBD-alone administration. However, MK-801 increased the PPI response of our animals. CBD pre-treatment blocked the PPI increase induced by MK-801. Our findings suggest that CBD's reversal of the MK-801 effects on PPI is unlikely to stem from a direct involvement on sensorimotor mechanisms, but may possibly reflect its anxiolytic properties.
authors.affiliation: Primate Center and Laboratory of Neurosciences and Behavior, Department of Physiological Sciences, Institute of Biology, University of Brasilia Brasilia, Brazil.
authors.forename: Patricia G
authors.initials: PG
authors.lastname: Saletti
authors.affiliation: Primate Center and Laboratory of Neurosciences and Behavior, Department of Physiological Sciences, Institute of Biology, University of BrasiliaBrasilia, Brazil; Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska University HospitalStockholm, Sweden.
authors.forename: Rafael S
authors.initials: RS
authors.lastname: Maior
authors.affiliation: Department of Pharmaceutical Sciences, School of Health Sciences, University of Brasilia Brasilia, Brazil.
authors.forename: Marilia
authors.initials: M
authors.lastname: Barros
authors.affiliation: System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Toyama, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Nishijo
authors.affiliation: Primate Center and Laboratory of Neurosciences and Behavior, Department of Physiological Sciences, Institute of Biology, University of BrasiliaBrasilia, Brazil; Neuroscience Research Group, University CEUMASão Luís, Brazil.
authors.forename: Carlos
authors.initials: C
authors.lastname: Tomaz
keywords: MK-801; cannabidiol (CBD); learning; memory; monkey; prepulse inhibition