title: Interferon-gamma-induced local leukocytoclastic vasculitis at the subcutaneous injection site.
abstract: Cutaneous reactions associated with interferons (IFNs) treatment are either localized or generalized. The most common presentation of localized reactions at IFNs injection site is usually an erythematous patch or plaque. Local leukocytoclastic vasculitis presenting with cutaneous necrosis is extremely rare. We report a 19-year-old man with hepatitis B who had local leukocytoclastic vasculitis induced by interferon-gama injection at the injection site. After changing the injection sites and using the combined treatment of prednisone and colchicine, the previous lesion healed and no other cutaneous lesion occurred. We also made a mini review of such cases.
authors.affiliation: The First Affiliated Hospital, SunYat-sen University - Guangzhou, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University - Guangzhou, China.
authors.forename: Juan-Hua
authors.initials: JH
authors.lastname: Liu
authors.affiliation: The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University - Guangzhou, China.
authors.forename: Yu-Kun
authors.initials: YK
authors.lastname: Zhao
authors.affiliation: The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University - Guangzhou, China.
authors.forename: Di-Qing
authors.initials: DQ
authors.lastname: Luo
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003078:Colchicine / Q000627:therapeutic use; D004890:Erythema / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D007279:Injections, Subcutaneous / Q000009:adverse effects; D007371:Interferon-gamma / Q000009:adverse effects*; D008297:Male; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D016896:Treatment Outcome; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D007371:Interferon-gamma; D003078:Colchicine; D011241:Prednisone