title: The Correlation Between Pre-treatment Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Parameters and Clinical Prognostic Factors in Pediatric Hodgkin Lymphoma.
abstract: OBJECTIVE
  To compare standardized uptake values (SUV) derived from pre-treatment18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging and clinical prognostic factors in pediatric patients with Hodgkin lymphoma (HL).
  
  
  METHODS
  Pre-treatment FDG PET/CT findings of 28 children with HL were evaluated in this retrospective study. Metabolic tumor volume (MTV), SUVmaxnormalized by weight (SUVweight), lean body mass (SUVlbm), body surface area (SUVbsa) and plasma glucose levels of tumors (SUVglucose) were calculated using pre-treatment FDG PET/CT scan images. These metabolic parameters were correlated with clinical factors [age, sex, number of lymph node groups, presence of splenic involvement, bulky mediastinal disease, Ann Arbor stage, serum white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), serum albumin and hemoglobin levels].
  
  
  RESULTS
  SUVbsa, SUVlbm, SUVweight, SUVglucoseand MTV were higher in patients with stage III-IV disease, bulky tumor and ≥3 lymph node groups (p<0.05). SUVbsaand SUVglucosewere higher in patients with splenic involvement (p<0.05). There was no significant correlation between these metabolic parameters and sex, ESR, levels of albumin and WBC (p>0.05). SUVbsaand SUVlbmwere higher in patients with anemia (p<0.05). Additionally, significant increases were detected in SUVweight, MTV, and SUVglucosewith increasing age (p=0.005, p=0.027, and p=0.009, respectively). SUVbsaand SUVlbmhad no significant correlation with age (p>0.05).
  
  
  CONCLUSIONS
  Metabolic parameters derived from pre-treatment FDG PET/CT may have an important role in predicting high-risk disease in patients with HL. Also, SUVbsaand SUVlbmmay be better markers than SUVweightin the quantitative evaluation of FDG PET/CT scans in pediatric patients.
authors.affiliation: Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Nuclear Medicine, Ankara, Turkey Phone: +90 505 914 53 61 E-mail: ebrualkandr@yahoo.com.
authors.forename: Ebru
authors.initials: E
authors.lastname: Tatcı
authors.forename: İnci
authors.initials: İ
authors.lastname: Uslu Biner
authors.forename: Suna
authors.initials: S
authors.lastname: Emir
authors.forename: Hikmet Gülşah
authors.initials: HG
authors.lastname: Tanyıldız
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Özmen
authors.forename: Engin
authors.initials: E
authors.lastname: Alagöz
authors.forename: Atila
authors.initials: A
authors.lastname: Gökçek
authors.forename: Gürses
authors.initials: G
authors.lastname: Şahin