title: Bone Healing Evaluation in Critical-Size Defects Treated With Xenogenous Bone Plus Porcine Collagen.
abstract: OBJECTIVE
  This study aimed to evaluate the osteoconductive features of Bio-Oss Collagen in large critical-size defects (8 mm).
  
  
  METHODS
  Thirty-six adult Wistar Albinus male adult rats were carried out a critical-size defect with a trephine bur of 8 mm in the calvaria. Groups were divided depending on the filling biomaterial as follows: group BO: Bio-Oss (n = 18); group BOC: Bio-Oss Collagen (n = 18). After 7, 30, and 60 days, 6 rats of each group were euthanized with anesthetic overdose. Specimens were laboratory processed for histomorphometric analysis. Histomorphometric data were statistically analyzed by analysis of variance and post-Tukey test (P < 0.05).
  
  
  RESULTS
  Statistical differences were found in new bone formation just in the intragroup comparison among periods after 7 and 60 postoperative days, indicating more new bone formation after 60 days (Tukey test, P = 0.029).
  
  
  CONCLUSIONS
  Under the limitation of this research, it could be concluded that Bio-Oss and Bio-Oss Collagen in this experimental model did not show osteoconductive features.
authors.affiliation: *PhD Student, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil. †MSc Student, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil. ‡Assistant Professor, Department of Oral Pathology, Faculty Adamantinenses Integradas, Adamantina, Sao Paulo, Brazil. §Full Professor, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil; Department of Oral Pathology, Faculty Adamantinenses Integradas, Adamantina, Sao Paulo, Brazil. ¶Assistant Professor, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil.
authors.forename: Juceléia
authors.initials: J
authors.lastname: Maciel
authors.forename: Gustavo Antonio Correa
authors.initials: GA
authors.lastname: Momesso
authors.forename: Gabriel
authors.initials: G
authors.lastname: Ramalho-Ferreira
authors.forename: Renata Bianco
authors.initials: RB
authors.lastname: Consolaro
authors.forename: Paulo Sérgio
authors.initials: PS
authors.lastname: Perri de Carvalho
authors.forename: Leonardo Perez
authors.initials: LP
authors.lastname: Faverani
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Farnezi Bassi
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D003094:Collagen / Q000627:therapeutic use*; D008297:Male; D008903:Minerals / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000293:injuries; D013552:Swine
chemical_list: C077540:Bio-Oss; D008903:Minerals; D003094:Collagen