title: Cyclophilin D regulates lifespan and protein expression of aging markers in the brain of mice.
abstract: Cyclophilin D (cypD) modulates the properties of the permeability transition pore, a phenomenon implicated in the manifestation of many diseases including aging. Here, we examined the effects of partial or complete deletion of cypD on i) lifespan, ii) forebrain protein expression of 18 aging markers as well as regional expression of GFAP, mGluR1, and alpha-synuclein, and iii) behaviour of aged (>24month) male and female mice. Both male and female cypD heterozygous but not KO mice exhibited increased lifespans compared to WT littermates, associated with alterations in the protein expression of some markers, albeit without exhibiting changes in behaviour.
authors.affiliation: Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
authors.forename: Viktoria
authors.initials: V
authors.lastname: Vereczki
authors.affiliation: Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary; MTA-SE Lendület Neurobiochemistry Research Group, Budapest, Hungary.
authors.forename: Josef
authors.initials: J
authors.lastname: Mansour
authors.affiliation: Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary; MTA-SE Lendület Neurobiochemistry Research Group, Budapest, Hungary.
authors.forename: Issa
authors.initials: I
authors.lastname: Pour-Ghaz
authors.affiliation: Department of Human Morphology and Developmental Biology, Semmelweis University, Budapest, Hungary.
authors.forename: Ibolya
authors.initials: I
authors.lastname: Bodnar
authors.affiliation: Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Otto
authors.initials: O
authors.lastname: Pinter
authors.affiliation: Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Dora
authors.initials: D
authors.lastname: Zelena
authors.affiliation: Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
authors.forename: Erzsebet
authors.initials: E
authors.lastname: Oszwald
authors.affiliation: Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary; MTA-SE Laboratory for Neurobiochemistry, Budapest, Hungary.
authors.forename: Vera
authors.initials: V
authors.lastname: Adam-Vizi
authors.affiliation: Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary; MTA-SE Lendület Neurobiochemistry Research Group, Budapest, Hungary. Electronic address: chinopoulos.christos@eok.sote.hu.
authors.forename: Christos
authors.initials: C
authors.lastname: Chinopoulos
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D001522:Behavior, Animal; D000081406:Peptidyl-Prolyl Isomerase F; D021983:Cyclophilins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D055786:Gene Knockout Techniques; D006801:Humans; D008297:Male; D008810:Mice, Inbred C57BL; D016548:Prosencephalon / Q000473:pathology*
chemical_list: D000081406:Peptidyl-Prolyl Isomerase F; C000631446:PPIF protein, mouse; D021983:Cyclophilins
keywords: Alpha-synuclein; GFAP; Heterozygote; Mitochondria; Permeability transition; mGluR1