title: A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide-induced anemic rats.
abstract: By using a feedback system control scheme, the best combination of formononetin, ononin, calycosin, and calycosin-7-O-β-d-glucoside derived from Astragali Radix was shown to activate a hypoxia response element, a regulator for erythropoietin (EPO) transcription, in kidney fibroblast. In cyclophosphamide-induced anemic rats, the treatment of combined flavonoids, or EPO, improved the levels of red blood cells, white blood cells, hemoglobin, and hematocrit. In addition, the altered levels of antioxidant capacity, super oxidase dismutase, and malondialdehyde, triggered in anemic rats, were restored to control levels by the treatment of flavonoids. Here, we proposed a possible therapy by using the common flavonoids in treating anemia.
authors.affiliation: Division of Life Science and Center for Chinese Medicine The Hong Kong University of Science and Technology China; School of Pharmacy Shanghai University of Traditional Chinese Medicine China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Division of Life Science and Center for Chinese Medicine The Hong Kong University of Science and Technology China.
authors.forename: Amy G W
authors.initials: AG
authors.lastname: Gong
authors.affiliation: Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and Technology China.
authors.forename: Kashif
authors.initials: K
authors.lastname: Riaz
authors.affiliation: Division of Life Science and Center for Chinese Medicine The Hong Kong University of Science and Technology China.
authors.forename: Jun Y
authors.initials: JY
authors.lastname: Deng
authors.affiliation: Department of Mechanical and Aerospace Engineering University of California Los Angeles CA USA.
authors.forename: Chih M
authors.initials: CM
authors.lastname: Ho
authors.affiliation: Division of Life Science and Center for Chinese Medicine The Hong Kong University of Science and Technology China; HKUST Shenzhen Research Institute Nanshan Shenzhen Guangdong Province China.
authors.forename: Huang Q
authors.initials: HQ
authors.lastname: Lin
authors.affiliation: Division of Life Science and Center for Chinese Medicine The Hong Kong University of Science and Technology China; HKUST Shenzhen Research Institute Nanshan Shenzhen Guangdong Province China.
authors.forename: Tina T X
authors.initials: TT
authors.lastname: Dong
authors.affiliation: Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and Technology China.
authors.forename: Yi-Kuen
authors.initials: YK
authors.lastname: Lee
authors.affiliation: Division of Life Science and Center for Chinese Medicine The Hong Kong University of Science and Technology China; HKUST Shenzhen Research Institute Nanshan Shenzhen Guangdong Province China.
authors.forename: Karl W K
authors.initials: KW
authors.lastname: Tsim
keywords: feedback system control; flavonoids combination; hematological parameters