title: [Tenofovir-associated Fanconi`s syndrome and rickets in a HIV infected girl].
abstract: Tenofovir (TDF) is an inhibitor of reverse transcriptase nucleotide analogue, although it has good tolerability and high anti-retroviral activity, its effect on the kidney has been a concern.
  
  
  OBJECTIVE
  To describe a girl infected with HIV who presented Fanconi syndrome during antiretroviral therapy with TDF.
  
  
  METHODS
  We describe a HIV-1-infected girl, who after 18 months treatment with TDF presented loss of strength and pain of the lower extremities with functional impairment. Laboratory findings were consistent with Fanconi syndrome. Radiographs showed bilateral hip fracture and wrists. Full recovery of Fanconi syndrome was achieved four months after changing antiretroviral therapy.
  
  
  CONCLUSIONS
  TDF-prescribing physicians must be prepared to detect signs and symptoms of renal dysfunction and immediately consider switching to another antiviral drug.
authors.affiliation: Departamentos de Pediatría y Cirugía Norte, Hospital Roberto del Río, Universidad de Chile, Santiago, Chile.
authors.forename: Marcela
authors.initials: M
authors.lastname: Zúñiga
authors.affiliation: Departamentos de Pediatría y Cirugía Norte, Hospital Roberto del Río, Universidad de Chile, Santiago, Chile.
authors.forename: Armando
authors.initials: A
authors.lastname: Galindo
authors.affiliation: Unidad de Enfermedades Infecciosas Pediátricas, Hospital Roberto del Río, Santiago, Chile.
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Galaz
authors.affiliation: Departamentos de Pediatría y Cirugía Norte, Hospital Roberto del Río, Universidad de Chile, Santiago, Chile.
authors.forename: Maritza
authors.initials: M
authors.lastname: Vivanco
authors.affiliation: Unidad de Endocrinología Pediátrica, Hospital Roberto del Río, Universidad de Chile, Santiago, Chile.
authors.forename: Patricio
authors.initials: P
authors.lastname: Romero
authors.affiliation: Departamentos de Pediatría y Cirugía Norte, Hospital Roberto del Río, Universidad de Chile, Santiago, Chile.
authors.forename: Paulina
authors.initials: P
authors.lastname: Balboa
authors.affiliation: Departamentos de Pediatría y Cirugía Norte, Hospital Roberto del Río, Universidad de Chile, Santiago, Chile.
authors.forename: Claudia
authors.initials: C
authors.lastname: Torrejón
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D012279:Rickets / Q000139:chemically induced*; D000068698:Tenofovir / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D019380:Anti-HIV Agents; D000068698:Tenofovir