title: The prevalence of HPV infections in HPV-vaccinated women from the general population.
abstract: Currently, three prophylactic HPV vaccines are commercially available to prevent HPV 16/18 infection and associated lesions. The aim of the study was to assess markers of HPV infection in women/girls before vaccination and to ascertain the prevalence and spectrum of post-vaccination HPV types. Three hundred and thirty subjects of which 75 were virgins were enrolled. Before the first dose of the HPV vaccine and 1, 3 and 5 years after the completion of HPV vaccination, the samples for cytology, HPV detection and anti-HPV antibody response were taken. At enrolment, HPV DNA was detected in 38% of sexually active girls/women. At the first, second and third follow-up, HPV DNA was found in 40, 45, and 39% of them. The seroprevalence rates to HPV 6, 11, 16 and 18 in these subjects were 31, 21, 18 and 10%. On the follow-up significantly higher levels of antibodies to HPV 16/18 were found after application of divalent vaccine. Results of the study demonstrate high prevalence of HPV infection in young women. In a substantial number of women, HPV-specific antibodies as well as high-risk HPV types were detected. HPV-specific antibodies were also frequently found in non-sexually active girls. The acquisition of HPV after the onset of sexual life was very fast.
authors.affiliation: Department of Immunology, Institute of Haematology and Blood Transfusion, Prague, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Hamsikova
authors.affiliation: Department of Immunology, Institute of Haematology and Blood Transfusion, Prague, Czech Republic.|Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Smahelova
authors.affiliation: Department of Immunology, Institute of Haematology and Blood Transfusion, Prague, Czech Republic.
authors.forename: Viera
authors.initials: V
authors.lastname: Ludvikova
authors.affiliation: Department of Immunology, Institute of Haematology and Blood Transfusion, Prague, Czech Republic.|Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Salakova
authors.affiliation: Department of Immunology, Institute of Haematology and Blood Transfusion, Prague, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Rychla
authors.affiliation: Clinics of Obstetrics & Gynaecology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Skrenkova
authors.affiliation: Departments of Obstetrics and Gynaecology, 2nd Faculty of Medicine, Charles University Prague, Prague, Czech Republic.
authors.forename: Lukas
authors.initials: L
authors.lastname: Rob
authors.affiliation: Department of Immunology, Institute of Haematology and Blood Transfusion, Prague, Czech Republic.|Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
authors.forename: Ruth
authors.initials: R
authors.lastname: Tachezy
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D053918:Papillomavirus Vaccines
keywords: 
  DNA
  ; 
  HPV
  ; antibodies; infection; persistence; vaccination