title: Manganese Complex of Ethylenediaminetetraacetic Acid (EDTA)-Benzothiazole Aniline (BTA) Conjugate as a Potential Liver-Targeting MRI Contrast Agent.
abstract: A novel manganese(II) complex based on an ethylenediaminetetraacetic acid (EDTA) coordination cage bearing a benzothiazole aniline (BTA) moiety (Mn-EDTA-BTA) was designed and synthesized for use as a liver-specific MRI contrast agent with high chelation stability. In addition to forming a hydrophilic, stable complex with Mn2+, this new Mn chelate was rapidly taken up by liver hepatocytes and excreted by the kidneys and biliary system. The kinetic inertness and R1relaxivity of the complex were much higher than those of mangafodipir trisodium (MnDPDP), a clinically approved liver-specific MRI contrast agent. The diagnostic utility of this new Mn complex in MRI was demonstrated by high-sensitivity tumor detection in an animal model of liver cancer.
authors.forename: Md Kamrul
authors.initials: MK
authors.lastname: Islam
authors.forename: Soyeon
authors.initials: S
authors.lastname: Kim
authors.forename: Hee-Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: Subin
authors.initials: S
authors.lastname: Park
authors.forename: Gang-Ho
authors.initials: GH
authors.lastname: Lee
authors.forename: Hyo Jeung
authors.initials: HJ
authors.lastname: Kang
authors.forename: Jae-Chang
authors.initials: JC
authors.lastname: Jung
authors.affiliation: Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation , Chumbok-ro 80, Dong-gu, Daegu 41061, Korea.
authors.forename: Joon-Suk
authors.initials: JS
authors.lastname: Park
authors.forename: Tae-Jeong
authors.initials: TJ
authors.lastname: Kim
authors.forename: Yongmin
authors.identifier: 0000-0002-0585-8714
authors.initials: Y
authors.lastname: Chang
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D000818:Animals; D052160:Benzothiazoles / Q000737:chemistry* / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D002614:Chelating Agents / Q000737:chemistry / Q000493:pharmacokinetics; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics; D056831:Coordination Complexes / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D004492:Edetic Acid / Q000737:chemistry*; D022781:Hepatocytes / Q000473:pathology; D006801:Humans; D008099:Liver / Q000166:cytology / Q000000981:diagnostic imaging* / Q000473:pathology; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008345:Manganese / Q000737:chemistry* / Q000493:pharmacokinetics; D008807:Mice, Inbred BALB C; D008819:Mice, Nude
chemical_list: D000814:Aniline Compounds; D052160:Benzothiazoles; D002614:Chelating Agents; D003287:Contrast Media; D056831:Coordination Complexes; D008345:Manganese; D004492:Edetic Acid