title: Pannexin hemichannels: A novel promising therapy target for oxidative stress related diseases.
abstract: Pannexins, which contain three subtypes: pannexin-1, -2, and -3, are vertebrate glycoproteins that form non-junctional plasma membrane intracellular hemichannels via oligomerization. Oxidative stress refers to an imbalance of the generation and elimination of reactive oxygen species (ROS). Studies have shown that elevated ROS levels are pivotal in the development of a variety of diseases. Recent studies indicate that the occurrence of these oxidative stress related diseases is associated with pannexin hemichannels. It is also reported that pannexins regulate the production of ROS which in turn may increase the opening of pannexin hemichannels. In this paper, we review recent researches about the important role of pannexin hemichannels in oxidative stress related diseases. Thus, pannexin hemichannels, novel therapeutic targets, hold promise in managing oxidative stress related diseases such as the tumor, inflammatory bowel diseases (IBD), pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), cardiovascular disease, insulin resistance (IR), and neural degeneration diseases.
authors.affiliation: Learning Key Laboratory for Pharmacoproteomics, Institute of Pharmacy and Pharmacology, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, P. R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.affiliation: Learning Key Laboratory for Pharmacoproteomics, Institute of Pharmacy and Pharmacology, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, P. R. China.
authors.forename: Linxi
authors.initials: L
authors.lastname: Chen
authors.affiliation: Learning Key Laboratory for Pharmacoproteomics, Institute of Pharmacy and Pharmacology, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, P. R. China.
authors.forename: Lanfang
authors.identifier: http://orcid.org/0000-0001-7510-8751
authors.initials: L
authors.lastname: Li
mesh_terms: D001692:Biological Transport / Q000502:physiology; D002318:Cardiovascular Diseases / Q000473:pathology; D049109:Cell Proliferation / Q000502:physiology; D017630:Connexins / Q000378:metabolism*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000473:pathology; D007333:Insulin Resistance / Q000502:physiology; D009369:Neoplasms / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D017630:Connexins; D009419:Nerve Tissue Proteins; C492764:PANX1 protein, human; C492765:PANX2 protein, human; C492766:PANX3 protein, human; D017382:Reactive Oxygen Species
keywords: ATP; oxidative stress; pannexins