title: Influence of graphene-oxide nanosheets impregnation on properties of sterculia gum-polyacrylamide hydrogel formed by radiation induced polymerization.
abstract: Present work is an attempt, to explore the potential of graphene oxide nanoplates impregnation, on the mechanical and drug delivery properties of sterculia gum-polyacrylamide composite hydrogel formed by radiation induced polymerization. These polymers were characterized by SEM, cryo-SEM, AFM, FTIR's,13C NMR and swelling studies. Release profile of an anticancer drug 'gemcitabine' was studied to determine the drug release mechanism and best fit kinetic model. Furthermore, some important biomedical properties of the polymers such as blood compatibility, mucoadhesion, antioxidant properties and gel strength were also studied. Impregnation of GO into sterculia gum-poly(AAm) hydrogels decreased the swelling of hydrogels but improved the mechanical, drug loading and drug release properties of the hydrogels. Release of gemcitabine from drug loaded hydrogels occurred through non-Fickian diffusion mechanism and release profile was best fitted in first order kinetic model. These hydrogels have been found as haemocompatible, mucoadhesive, and antioxidant in nature.
authors.affiliation: Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India. Electronic address: baljitsinghhpu@yahoo.com.
authors.forename: Baljit
authors.initials: B
authors.lastname: Singh
authors.affiliation: Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India.
authors.forename: Baldev
authors.initials: B
authors.lastname: Singh
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000268:Adhesiveness; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D065546:Drug Liberation; D024841:Fluoroquinolones / Q000737:chemistry; D000077735:Gemifloxacin; D006108:Graphite / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D007413:Intestinal Mucosa / Q000737:chemistry; D007618:Karaya Gum / Q000737:chemistry*; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry; D009287:Naphthyridines / Q000737:chemistry; D010087:Oxides / Q000737:chemistry*; D058105:Polymerization; D011827:Radiation; D032361:Sterculia / Q000737:chemistry; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D000975:Antioxidants; D001672:Biocompatible Materials; D004337:Drug Carriers; D024841:Fluoroquinolones; D000077735:Gemifloxacin; D006108:Graphite; D020100:Hydrogels; D007618:Karaya Gum; D009287:Naphthyridines; D010087:Oxides; D000099166:Polyacrylamides
keywords: Drug delivery; Gemcitabine; Grapheme oxide; Hydrogels