title: [Azilsartan Medoxomil Capabilities in Arterial Hypertension and Obesity].
abstract: Arterial hypertension (AH) is one of the most common cardiovascular disease. Angiotensin II (AT II), the hormone of renin-angiotensin-aldosterone system, realizes its negative effects through AT 1 receptors - application point of angiotensin receptor blockers (ARB). Due to different dissociation AT 1 receptors properties some ARBs are more effective than others. Multiply multicenter randomized and observational studies approve the effectiveness and safety of azilsartan medoxomil in patients with AH 1-2 grade. Several preclinical studies have shown the additional properties of azilsartan, including increase of insulin sensitivity, cardio- and nephron protection in obesity. In our clinical case we showed the positive influence of azilsartan medoxomil on clinic and ambulatory blood pressure, 24-hour aortic stiffness parameters, longitudinal left ventricular strain in patient with AH and obesity.
authors.affiliation: A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
authors.forename: Y A
authors.initials: YA
authors.lastname: Vasyuk
authors.affiliation: A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
authors.forename: E Y
authors.initials: EY
authors.lastname: Shupenina
authors.affiliation: A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Nesvetov
authors.affiliation: A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Nesterova
authors.affiliation: A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Golubkova
mesh_terms: D000328:Adult; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D018660:Blood Pressure Monitoring, Ambulatory; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009765:Obesity / Q000150:complications; D010069:Oxadiazoles / Q000627:therapeutic use*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D001562:Benzimidazoles; D010069:Oxadiazoles; C557413:azilsartan medoxomil
keywords: 24-hour central blood pressure; aortic stiffness; arterial hypertension; azilsartan medoxomil; left ventricular strain assessment; obesity