title: MicroRNA applications for prostate, ovarian and breast cancer in the era of precision medicine.
abstract: The high degree of conservation in microRNA fromCaenorhabditiselegansto humans has enabled relatively rapid implementation of findings in model systems to the clinic. The convergence of the capacity for genomic screening being implemented in the prevailing precision medicine initiative and the capabilities of microRNA to address these changes holds significant promise. However, prostate, ovarian and breast cancers are heterogeneous and face issues of evolving therapeutic resistance. The transforming growth factor-beta (TGFβ) signaling axis plays an important role in the progression of these cancers by regulating microRNAs. Reciprocally, microRNAs regulateTGFβactions during cancer progression. One must consider the expression of miRNA in the tumor microenvironment a source of biomarkers of disease progression and a viable target for therapeutic targeting. The differential expression pattern of microRNAs in health and disease, therapeutic response and resistance has resulted in its application as robust biomarkers. With two microRNA mimetics in ongoing restorative clinical trials, the paradigm for future clinical studies rests on the current observational trials to validate microRNA markers of disease progression. Some of today's biomarkers can be translated to the next generation of microRNA-based therapies.
authors.affiliation: Department of MedicineSamuel Ochin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Bethany
authors.initials: B
authors.lastname: Smith
authors.affiliation: Department of MedicineSamuel Ochin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Agarwal
authors.affiliation: Department of MedicineSamuel Ochin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA bhowmickn@cshs.org.|Greater Los Angeles Veterans AdministrationLos Angeles, California, USA.
authors.forename: Neil A
authors.initials: NA
authors.lastname: Bhowmick
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000502:physiology*; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: TGF-β; biomarker; clinical trials; microRNA; microenvironment