title: Can Skin Allograft Occasionally Act as a Permanent Coverage in Deep Burns? A Pilot Study.
abstract: BACKGROUND
  Skin allograft is the gold standard of wound coverage in patients with extensive burns; however, it is considered as a temporary wound coverage and rejection of the skin allograft is considered inevitable. In our study, skin allograft as a permanent coverage in deep burns is evaluated.
  
  
  METHODS
  Skin allograft survival was assessed in 38 patients from March 2009 to March 2014, retrospectively. Because of the lack of tissue specimen from the skin donors, patients with long skin allograft survival in whom the gender of donor and recipient of allograft was the same were excluded. Seven cases with skin allograft longevity and opposite gender in donor and recipient were finally enrolled. A polymerase chain reaction (PCR) test on the biopsy specimen from recipients and donors were undertaken.
  
  
  RESULTS
  PCR on the biopsy specimen from recipients confirmed those specimens belong to the donors. All patients received allograft from the opposite sex. Two (28.57%) patients received allograft from their first-degree blood relatives, and in one (14.29%) case, the allograft was harvested from an alive individual with no blood relation. The rest were harvested from multiorgan donors. In eight months of follow up, no clinical evidence of graft rejection was noted.
  
  
  CONCLUSIONS
  Long term persistence of skin allograft in patients is worthy of more attention. Further studies An increase in knowledge of factors influencing this longevity could realize the dream of burn surgeons to achieve a permanent coverage other than autograft for major burn patients.
authors.affiliation: Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Ezzatollah
authors.initials: E
authors.lastname: Rezaei
authors.affiliation: Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Beiraghi-Toosi
authors.affiliation: Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Ahmadabadi
authors.affiliation: Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Seyed Hassan
authors.initials: SH
authors.lastname: Tavousi
authors.affiliation: Iranian Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Alipour Tabrizi
authors.affiliation: Department of Surgery, Imam Khomeini Hospital, Northern Khorasan University of Medical Sciences, Shirvan, Iran.
authors.forename: Kazem
authors.initials: K
authors.lastname: Fotuhi
authors.affiliation: Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Jabbari Nooghabi
authors.affiliation: Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Manafi
authors.affiliation: School of Medicine, Islamic Azad University, Tehran Branch, Tehran, Iran.
authors.forename: Shokoofeh
authors.initials: S
authors.lastname: Ahmadi Moghadam
keywords: Burn; Polymerase chain reaction; Skin allograft