title: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A lymphocytic reactive response of the central nervous system? A case report.
abstract: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroid (CLIPPERS) was first described in 2010. The characteristic clinical picture, radiological distribution and steroid response have been well-described in previous reports. However, the underlying pathogenesis and nosological position of CLIPPERS in the CNS require further investigation for the primary CNS lymphoma have been identified by autopsy subsequently. Here, we report a 51-year-old woman who was diagnosed with CLIPPERS but progressed to primary CNS lymphomatoid granulomatosis, which supports that CLIPPERS is not just an inflammatory CNS disorder.
authors.affiliation: The PLA General Hospital, Department of Neurology, PR China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Wang
authors.affiliation: The PLA General Hospital, Department of Neurology, PR China.
authors.forename: Dehui
authors.initials: D
authors.lastname: Huang
authors.affiliation: The PLA General Hospital, Department of Neurology, PR China.
authors.forename: Xusheng
authors.initials: X
authors.lastname: Huang
authors.affiliation: The PLA General Hospital, Department of Neurology, PR China.
authors.forename: Jiatang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The PLA General Hospital, Department of Neurology, PR China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Ran
authors.affiliation: The PLA General Hospital, Department of Radiology, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lou
authors.affiliation: The PLA General Hospital, Department of Pathology, PR China.
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Gui
authors.affiliation: The PLA General Hospital, Department of Neurology, PR China. Electronic address: Yusy1963@126.com.
authors.forename: Shengyuan
authors.initials: S
authors.lastname: Yu
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D019394:Ki-67 Antigen / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011149:Pons / Q000473:pathology*; D013256:Steroids / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D015703:Antigens, CD; D019394:Ki-67 Antigen; D013256:Steroids
keywords: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS); Lymphocytic proliferative disease; Primary central nervous system lymphoma (PCNSL); Primary central nervous system lymphomatoid granulomatosis (PCNS-LYG)