title: RUNX1-ETO Leukemia.
abstract: AML1-ETO leukemia is the most common cytogenetic subtype of acute myeloid leukemia, defined by the presence of t(8;21). Remarkable progress has been achieved in understanding the molecular pathogenesis of AML1-ETO leukemia. Proteomic surveies have shown that AML-ETO forms a stable complex with several transcription factors, including E proteins. Genome-wide transcriptome and ChIP-seq analyses have revealed the genes directly regulated by AML1-ETO, such as CEBPA. Several lines of evidence suggest that AML1-ETO suppresses endogenous DNA repair in cells to promote mutagenesis, which facilitates acquisition of cooperating secondary events. Furthermore, it has become increasingly apparent that a delicate balance of AML1-ETO and native AML1 is important to sustain the malignant cell phenotype. Translation of these findings into the clinical setting is just beginning.
authors.affiliation: Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Shan
authors.initials: S
authors.lastname: Lin
authors.affiliation: Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Mulloy
authors.affiliation: Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. goyama@ims.u-tokyo.ac.jp.
authors.forename: Susumu
authors.initials: S
authors.lastname: Goyama
mesh_terms: D000818:Animals; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics* / Q000378:metabolism*; D004260:DNA Repair / Q000235:genetics / Q000502:physiology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism*; D016296:Mutagenesis / Q000235:genetics / Q000502:physiology; D040901:Proteomics / Q000379:methods; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D059467:Transcriptome / Q000235:genetics / Q000502:physiology
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D014157:Transcription Factors
keywords: AML1(RUNX1); AML1-ETO (RUNX1-ETO); Acute myeloid leukemia; DNA repair; Epigenetics; Signal transduction; Transcription factor complex