title: Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease.
abstract: Cholesterol-rich, apolipoprotein B (apoB)-containing lipoproteins are now widely accepted as the most important causal agents of atherosclerotic cardiovascular disease. Multiple unequivocal and orthogonal lines of evidence all converge on low-density lipoprotein and related particles as being the principal actors in the genesis of atherosclerosis. Here, we review the fundamental role of atherogenic apoB-containing lipoproteins in cardiovascular disease and several other humoral and parietal factors that are required to initiate and maintain arterial degeneration. The biology of foam cells and their interactions with high-density lipoproteins, including cholesterol efflux, are also briefly reviewed.
authors.affiliation: Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Shapiro
authors.affiliation: Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.
authors.forename: Sergio
authors.initials: S
authors.lastname: Fazio
keywords: HDL; apoB; apolipoprotein B; arterial degeneration; atherogenic apoB-lipoprotein; atherosclerotic cardiovascular disease; foam cell