title: Characterization of H5N1 highly pathogenic mink influenza viruses in eastern China.
abstract: Members of the H5 subtype of highly pathogenic avian influenza viruses pose a great threat to both poultry and humans with severe consequences for both industry and public health sectors. Here, we isolated and characterized two H5N1 highly pathogenic influenza viruses in deceased mink from eastern China. Phylogenetic analyses showed that the G15 and XB15 viruses belonged to clade 2.3.2.1b and 2.3.2.1e, respectively. Both of these viruses were highly pathogenic in chickens. They were also shown to exhibit moderate to high pathogenicity in mice without pre-adaptation. Further, the mink influenza viruses had severe antigenic drift with corresponding Re-6 vaccine and current vaccines may fail to confer protection against these H5N1 viruses in poultry.
authors.affiliation: China Animal Health and Epidemiology Center, Qingdao, China. Electronic address: civcul@163.com.
authors.forename: Wenming
authors.initials: W
authors.lastname: Jiang
authors.affiliation: China Animal Health and Epidemiology Center, Qingdao, China.
authors.forename: Suchun
authors.initials: S
authors.lastname: Wang
authors.affiliation: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
authors.forename: Chuanmei
authors.initials: C
authors.lastname: Zhang
authors.affiliation: China Animal Health and Epidemiology Center, Qingdao, China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Li
authors.affiliation: China Animal Health and Epidemiology Center, Qingdao, China.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Hou
authors.affiliation: China Animal Health and Epidemiology Center, Qingdao, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: China Animal Health and Epidemiology Center, Qingdao, China.
authors.forename: Jiming
authors.initials: J
authors.lastname: Chen
authors.affiliation: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Shan
mesh_terms: D000818:Animals; D000940:Antigenic Variation; D002645:Chickens; D002681:China; D005260:Female; D053124:Influenza A Virus, H5N1 Subtype / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D007252:Influenza Vaccines / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008907:Mink / Q000821:virology*; D009976:Orthomyxoviridae Infections / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D011201:Poultry Diseases / Q000517:prevention & control* / Q000821:virology; D017422:Sequence Analysis, DNA / Q000662:veterinary; D013047:Specific Pathogen-Free Organisms; D014611:Vaccination / Q000662:veterinary*; D014774:Virulence
chemical_list: D007252:Influenza Vaccines
keywords: Antigenicity; H5N1; Mink; Pathogenicity