title: [Safety and Efficacy of Amlodipine, Lisinopril and Rosuvastatin Therapy in Patients With Metabolic Syndrome and Nonalcoholic Fatty Liver Disease].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of amlodipin, lisinopril and rosuvastatin therapy in metabolic syndrome and high cardiovascular risk patients with nonalcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  6 months randomized study of fixed combination of amlodipin and lisinopril with or without rosuvastatin of 20 patients with 2 grade of arterial hypertension, dyslipidemia with metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). Efficacy and safety was revealed: office BP, ABPM, NAFLD Fibrosis scale, insulin resistance index (HOMA-IR), serum lipids were measured basically and after 6 months of therapy.
  
  
  RESULTS
  6 months amlodipin and lisinopril therapy results: office BP decreased from 153,4+/-2,9/83,3+/-2,5 to 131,0+/-2,4/79,9+/-4,5 mm Hg (=0,001, for systolic BP).159/91 to 132/77 mm Hg. 24-hours BP decreased from 153,6+/-3,6/89,5+/-3,2 to 127,1+/-3,0/73,5+/-2,9 (=0,002); in 85% of patients BP normalized. Low density lipoprotein cholesterol (LDL-C) decreased lower 2.5 mmol/l in all patients and lower 1.8 mmol/l in 45% patients on rosuvastatin therapy. Before therapy 3 patients had elevated ALT levels, after 6 months therapy all patients had normal levels of ALT and AST. ALT decreased from 33,7+/-4,3 to 23,2+/-3,5 U/l (=0,01). Alkaline phosphatase decreased from 65,4+/-4,1 to 51,1+/-6,9 U/l (=0,02), gamma glutamyl transpeptidase level was stable. NAFLD Fibrosis index revealed fibrosis and was stable -0,9+/-0,2 and -0,9+/-0,2 (>0,05). HOMA-IR decreased from 4.2+/-0,4 to 2,9+/-0,4 (=0,02).
  
  
  CONCLUSIONS
  Some antihypertensive drugs and statins can be hepatotoxic especially in patients with metabolic syndrome and NAFLD. Antihypertensive drugs and statins with minimal liver metabolism can be preferable in NAFLD patients.
  
  
  CONCLUSIONS
  Amlodipin, lisinopril and rosuvastatin therapy is effective and safe in patients with metabolic syndrome of high cardiovascular risk and liver steatosis.
authors.affiliation: 1I.P. Pavlov First St.-Petersburg State Medical University, St.-Petersburg, Russia; 2Almazov Federal North-West Medical Research Centre, St.-Petersburg, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Baranova
authors.affiliation: 1I.P. Pavlov First St.-Petersburg State Medical University, St.-Petersburg, Russia; 2Almazov Federal North-West Medical Research Centre, St.-Petersburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Berezina
authors.affiliation: 1I.P. Pavlov First St.-Petersburg State Medical University, St.-Petersburg, Russia; 2Almazov Federal North-West Medical Research Centre, St.-Petersburg, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Melioranskaya
authors.affiliation: 1I.P. Pavlov First St.-Petersburg State Medical University, St.-Petersburg, Russia; 2Almazov Federal North-West Medical Research Centre, St.-Petersburg, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Polyakova