title: Successful salvage treatment of native valve Enterococcus faecalis infective endocarditis with telavancin: two case reports.
abstract: Infective endocarditis (IE) one-year mortality rates approach 40%. Here, we report two native valve Enterococcus faecalis IE cases in patients successfully treated with telavancin. An 88-year-old with mitral valve endocarditis and a penicillin allergy, initially treated with intravenous vancomycin, was switched to telavancin. A 69-year-old, who previously received amoxicillin and intravenous vancomycin for presumed enterococcal bacteraemia, was diagnosed with dual valve endocarditis for which he received telavancin. Both received six weeks of telavancin. Neither had telavancin-related adverse events, evidence of infection at six months, nor required telavancin dosing adjustments. Documented use of novel treatments for serious enterococcal infections is needed.
authors.affiliation: a Huntsville Hospital , Department of Pharmacy Services , Huntsville , AL , USA.
authors.forename: Mickala M
authors.initials: MM
authors.lastname: Thompson
authors.affiliation: b Alabama Infectious Diseases Center , Huntsville , AL , USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Hassoun
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000617:Aminoglycosides / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology; D013293:Enterococcus faecalis / Q000187:drug effects / Q000302:isolation & purification*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D000077427:Lipoglycopeptides; D008297:Male; D016879:Salvage Therapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000077427:Lipoglycopeptides; C487637:telavancin
keywords: Native valve endocarditis; enterococcal; telavancin; vegetation