title: Early-onset preeclampsia is associated with perinatal mortality and severe neonatal morbidity.
abstract: OBJECTIVE
  To evaluate neonatal outcomes of pregnancies complicated by early-onset preeclampsia (PE) and compare these outcomes to those of gestational age matched neonates born to mothers whose pregnancy was not complicated by early-onset PE.
  
  
  METHODS
  We analyzed the outcome in 97 neonates born to mothers with early-onset PE (24-32 weeks amenorrhea at diagnosis) and compared it to that of 680 gestational age-matched neonates born between 25-36 weeks due to other etiologies and admitted to the Neonatal Intensive Care Unit (NICU) of a tertiary referral hospital in the Netherlands. We used Chi-square test, Wilcoxon test, and logistic regression analyses.
  
  
  RESULTS
  Neonates born to PE mothers had a higher perinatal mortality (13% vs. 7%, p = 0.03) and infant mortality (16% vs. 9%, p= 0.03), a 20% lower birth weight (1150 vs. 1430 g, p<0.001), were more often SGA (22% vs. 9%, p < 0.001) and had more neonatal complications as compared to neonates born to mothers without PE.
  
  
  CONCLUSIONS
  Overall adverse perinatal outcome is significantly worse in neonates born to mothers with early-onset PE. The effect of early-onset PE on perinatal mortality seems partially due to SGA. Whether these differences are due to uteroplacental factors or intrinsic neonatal factors remains to be elucidated.
authors.affiliation: a Department of Obstetrics and Gynecology , Radboud University Medical Centre, Nijmegen , the Netherlands.
authors.forename: Joris J A
authors.initials: JJA
authors.lastname: van Esch
authors.affiliation: b Department of Neonatology , Radboud University Medical Centre, Nijmegen , the Netherlands.
authors.forename: Arno F
authors.initials: AF
authors.lastname: van Heijst
authors.affiliation: c Department for Health Evidence , Radboud University Medical Centre, Nijmegen , the Netherlands.
authors.forename: Anton F J
authors.initials: AFJ
authors.lastname: de Haan
authors.affiliation: a Department of Obstetrics and Gynecology , Radboud University Medical Centre, Nijmegen , the Netherlands.
authors.forename: Olivier W H
authors.initials: OWH
authors.lastname: van der Heijden
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology*; D009017:Morbidity; D009426:Netherlands / Q000453:epidemiology; D054238:Perinatal Mortality; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000401:mortality; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012189:Retrospective Studies; D055815:Young Adult
keywords: Early-onset preeclampsia; SGA; mortality; perinatal outcome; preterm birth