title: [Free Radical Processes Play an Important Role in the Etiology and Pathogenesis of Atherosclerosis and Diabetes].
abstract: In this review, we present with exhaustive completeness the data of foreign studies and results of many years of own research, evidencing of the important role of free radical processes in the etiology and pathogenesis of atherosclerosis. The review contains the rationale for the concept that oxidative stress in atherosclerosis is even more developed during disorders of carbohydrate metabolism, contributing to the emergence of carbonyl stress in diabetes. We hypothesize that there exists a single common molecular mechanism of primary preatherogenic damages of vessel walls in atherosclerosis and diabetes, which enhances the formation of carbonyl-modified low-density lipoproteins to be accumulated in the foam cells. Possible reasons for failure of "antioxidant therapy" of atherosclerosis are discussed.
authors.affiliation: Institute of Cardiology of Russian Cardiology Scientific and Production Complex, Moscow, Russia.
authors.forename: V Z
authors.initials: VZ
authors.lastname: Lankin
authors.affiliation: Institute of Cardiology of Russian Cardiology Scientific and Production Complex, Moscow, Russia.
authors.forename: A K
authors.initials: AK
authors.lastname: Tikhaze
mesh_terms: D000975:Antioxidants; D050197:Atherosclerosis / Q000209:etiology / Q000378:metabolism; D003920:Diabetes Mellitus / Q000209:etiology / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D008077:Lipoproteins, LDL; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D008077:Lipoproteins, LDL
keywords: atherosclerosis; carbonyl stress; diabetes; free radicals; modified low-density lipoprotein; oxidative stress