title: The enigmatic oncogene and tumor suppressor-like properties of RAD54B: Insights into genome instability and cancer.
abstract: One of the major challenges to the cell is to ensure genome stability, which can be compromised through endogenous errors or exogenous DNA damaging agents, such as ionizing radiation or common chemotherapeutic agents. To maintain genome stability the cell has a multifaceted line of defense, including cell cycle checkpoints and DNA damage repair pathways. RAD54B is involved in many of these pathways and thus exhibits a role in maintaining and repairing genome stability following DNA damage. RAD54B is involved in cell cycle regulation after DNA damage and participates in homologous recombinational repair, which ensures the precise repair of the most deleterious DNA lesions, double-stranded breaks. This review focuses on structural aspects of RAD54B, molecular functions associated with its cellular roles in preventing genome instability, and how aberrant function contributes to oncogenesis. By understanding how aberrant RAD54B expression and/or function can contribute to oncogenesis, novel therapeutic approaches that specifically exploit these aberrant genetics are now being explored for precision medicine targeting. RAD54B represents an ideal candidate for synthetic genetic therapeutic approaches (synthetic dosage lethality or synthetic lethality), which are designed to target the specific genetics associated with cancer formation. These therapeutic approaches represent a precision-based approach, which is ideal as we are now entering the era of precision medicine.
authors.affiliation: Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.|Research Institute in Oncology and Hematology, CancerCare Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada.
authors.forename: Erin N
authors.initials: EN
authors.lastname: McAndrew
authors.affiliation: Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.|Research Institute in Oncology and Hematology, CancerCare Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada.
authors.forename: Kirk J
authors.identifier: 0000-0003-0081-8737
authors.initials: KJ
authors.lastname: McManus
mesh_terms: D059447:Cell Cycle Checkpoints; D004265:DNA Helicases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D004260:DNA Repair / Q000235:genetics; D016147:Genes, Tumor Suppressor; D042822:Genomic Instability / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D009857:Oncogenes / Q000235:genetics
chemical_list: D009687:Nuclear Proteins; C491221:RAD54B protein, human; D004265:DNA Helicases