title: Interplay between siderophores and colibactin genotoxin in Escherichia coli.
abstract: Highly pathogenic Escherichia coli strains that belong to the phylogenetic group B2 have developed a greater ability to acquire iron (heme receptor and numerous siderophores), to produce the genotoxin colibactin and to synthesize antimicrobial siderophore-microcins. There is an increased prevalence of these E. coli strains over the last 30 years in the intestinal microbiota in industrialized countries. Integrating the regulation of fitness/virulence factors, such as siderophores, colibactin and siderophore-microcins into networks that respond to specific environmental signals, such as the local iron concentration, could result in an accurate production of specific fitness/virulence factors, so that the E. coli can adapt to the competitive environment that is the gut and/or the blood. Iron deficiency is common in infancy, even in industrialized countries. Usual strategies for anemia correction are iron supplementation and iron fortification of foods. The long-term consequences and risks associated with high iron supply in the light of this iron-dependent network described in this review could explain at least in part the increased prevalence of E. coli B2 in the gut of people in industrialized countries. © 2017 IUBMB Life, 69(6):435-441, 2017.
authors.affiliation: IRSD, Université de Toulouse III Paul Sabatier, INSERM, INRA, ENVT, Toulouse, France.|Service de Bactériologie-Hygiène, CHU Toulouse, Toulouse, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Martin
authors.affiliation: IRSD, Université de Toulouse III Paul Sabatier, INSERM, INRA, ENVT, Toulouse, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Tronnet
authors.affiliation: IRSD, Université de Toulouse III Paul Sabatier, INSERM, INRA, ENVT, Toulouse, France.|Service de Bactériologie-Hygiène, CHU Toulouse, Toulouse, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Garcie
authors.affiliation: IRSD, Université de Toulouse III Paul Sabatier, INSERM, INRA, ENVT, Toulouse, France.|Service de Bactériologie-Hygiène, CHU Toulouse, Toulouse, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Oswald
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001430:Bacteriocins / Q000096:biosynthesis / Q000235:genetics; D019587:Dietary Supplements; D004758:Enterobactin / Q000096:biosynthesis / Q000235:genetics; D004926:Escherichia coli / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D000069196:Gastrointestinal Microbiome / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D007501:Iron / Q000008:administration & dosage / Q000378:metabolism*; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D061065:Polyketides / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D017262:Siderophores / Q000096:biosynthesis* / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D001430:Bacteriocins; D010455:Peptides; D061065:Polyketides; D012097:Repressor Proteins; D017262:Siderophores; D037521:Virulence Factors; C569566:colibactin; C068477:ferric uptake regulating proteins, bacterial; D004758:Enterobactin; D007501:Iron
keywords: E. coli; commensalism; iron; pathogenesis