title: Recent advances in understanding the cellular roles of GSK-3.
abstract: Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed protein kinase that sits at the nexus of multiple signaling pathways. Its deep integration into cellular control circuits is consummate to its implication in diseases ranging from mood disorders to diabetes to neurodegenerative diseases and cancers. The selectivity and insulation of such a promiscuous kinase from unwanted crosstalk between pathways, while orchestrating a multifaceted response to cellular stimuli, offer key insights into more general mechanisms of cell regulation. Here, we review recent advances that have contributed to the understanding of GSK-3 and its role in driving appreciation of intracellular signal coordination.
authors.affiliation: Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON, M5G 1X5, Canada.
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Cormier
authors.affiliation: Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON, M5G 1X5, Canada.
authors.forename: James R
authors.identifier: 0000-0003-3731-5797
authors.initials: JR
authors.lastname: Woodgett
keywords: GSK-3; GSK-3 biology; GSK-3 isoform; GSK-3 post-translational modification; glycogen synthase kinase-3