title: Bioactive Lipids and Circulating Progenitor Cells in Patients with Cardiovascular Disease.
abstract: Bone marrow-derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) were quantified using mass spectrometry. CPCs were assessed using flow cytometry. S1P levels correlated with the numbers of CD34+, CD34+/CD133+, and CD34+/CXCR4+ CPCs even after adjustment for potential confounding factors. However, no significant correlation was observed between C1P levels and CPC count. Plasma levels of S1P correlated with the number of CPCs in patients with coronary artery disease, suggesting an important mechanistic role for S1P in stem cell mobilization. The therapeutic effects of adjunctive S1P therapy to mobilize endogenous stem cells need to be investigated. Stem Cells Translational Medicine 2017;6:731-735.
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Salim S
authors.initials: SS
authors.lastname: Hayek
authors.affiliation: Lexington VA Medical Center and Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Klyachkin
authors.affiliation: Lexington VA Medical Center and Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA.|Kasr Alainy Faculty of Medicine, Department of Cardiology, Cairo University, Cairo, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Asfour
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Nima
authors.initials: N
authors.lastname: Ghasemzadeh
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Mosaab
authors.initials: M
authors.lastname: Awad
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Iraj
authors.initials: I
authors.lastname: Hesaroieh
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Hina
authors.initials: H
authors.lastname: Ahmed
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Brandon
authors.initials: B
authors.lastname: Gray
authors.affiliation: Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
authors.forename: Jinhee
authors.initials: J
authors.lastname: Kim
authors.affiliation: Kasr Alainy Faculty of Medicine, Department of Cardiology, Cairo University, Cairo, Egypt.
authors.forename: Edmund K
authors.initials: EK
authors.lastname: Waller
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Arshed A
authors.initials: AA
authors.lastname: Quyyumi
authors.affiliation: Lexington VA Medical Center and Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA.
authors.forename: Ahmed K
authors.initials: AK
authors.lastname: Abdel-Latif
mesh_terms: D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology*; D002452:Cell Count; D002465:Cell Movement; D005260:Female; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008246:Lysophospholipids / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
chemical_list: D008055:Lipids; D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D013110:Sphingosine
keywords: Ceramide-1 phosphate; Circulating progenitor cell; Coronary artery disease; Mobilization; Sphingosine-1 phosphate