title: [HAS-BLED and HEMORR2HAGES Scales in Assessment of Bleeding Risk in Patients on Long-Term Warfarin Therapy].
abstract: Aim of the study was to elucidate value of HAS-BLED and HEMORR2HAGES scales for prediction bleedings in patients receiving long-term warfarin (W) therapy.
  
  
  METHODS
  The study involved 119 patients (72 men) aged 60.9+/-9.6 years with atrial fibrillation or venous thromboembolic complications. Follow up period was 5.6 +/-3.4 years. All bleedings were categorized as 1) single bleeding with INR>4.0 during the 1st month of W therapy; 2) any single bleeding after 1st month of W therapy; 3) recurrent bleedings. CYP29 and VKORC1 (G3673A) genotypic variants were determined by PCR. Patients were divided into low (<3 points of HAS-BLED scale, n=58; <4 points.
authors.affiliation: Institute of Cardiology of Russian Cardiology Scientific and Production Complex, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Moreva
authors.affiliation: Institute of Cardiology of Russian Cardiology Scientific and Production Complex, Moscow, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Kropacheva
authors.affiliation: Institute of Cardiology of Russian Cardiology Scientific and Production Complex, Moscow, Russia.
authors.forename: E P
authors.initials: EP
authors.lastname: Panchenko
authors.affiliation: Institute of Cardiology of Russian Cardiology Scientific and Production Complex, Moscow, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Dobrovolsky
authors.affiliation: Institute of Cardiology of Russian Cardiology Scientific and Production Complex, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Zemlyanskaya
authors.affiliation: Institute of Cardiology of Russian Cardiology Scientific and Production Complex, Moscow, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Donnikov
authors.affiliation: Institute of Cardiology of Russian Cardiology Scientific and Production Complex, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Titaeva
authors.affiliation: Institute of Cardiology of Russian Cardiology Scientific and Production Complex, Moscow, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Guskov