title: Correlation between serum interleukin-6 level and type 1 diabetes mellitus: A systematic review and meta-analysis.
abstract: This report aimed to explore the association between the change of circulating interleukin-6 (IL-6) in patients and the development of type 1 diabetes mellitus (T1DM).
  
  
  
  Four databases (PubMed, CNKI, WanFang and Civip) were used to search and list all clinical case-control studies about serum IL-6 level in T1DM patients between Jan 1, 2000 and Aug 31, 2016.
  
  
  
  A total of 20 case-control studies with 1238 T1DM patients and 742 healthy controls were included in this study. Compared to healthy controls, the serum content of IL-6 in patients with T1DM was significantly greater (overall: SMD, 1.49; 95% CI, 1.04 to 1.93; p<0.001), and notably increased in all subgroup with different age, ethnic and disease duration (all p<0.001). Furthermore, the analysis in subgroup exhibited that serum levels of IL-6 in the age greater than 20-year old (SMD, 1.64; 95% CI, 0.57-2.71; p<0.001), the diseased duration among 0-10years (SMD, 2.43; 95% CI, 1.42-3.44; p<0.001) and the sorted American group (SMD, 1.68; 95% CI, 0.85-2.51; p<0.001) were higher than those in control groups.
  
  
  
  Patients with T1DM were found to be linked to elevated level of serum IL-6, which the age, ethnic and disease durations in T1DM patients had no effect on the serum IL-6 levels for promoting diabetes mellitus.
authors.affiliation: Center of Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Department of Immunology, Faculty of Basic Medical Science, Guilin Medical University, Guilin 541004, China.
authors.forename: Yin-Ling
authors.initials: YL
authors.lastname: Chen
authors.affiliation: Department of Immunology, School of Basic Medicine, Central South University, Changsha, Hunan 410078, China.
authors.forename: Yong-Chao
authors.initials: YC
authors.lastname: Qiao
authors.affiliation: Center of Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Department of Immunology, Faculty of Basic Medical Science, Guilin Medical University, Guilin 541004, China.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Pan
authors.affiliation: Department of Immunology, School of Basic Medicine, Central South University, Changsha, Hunan 410078, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Center of Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.
authors.forename: Yong-Cheng
authors.initials: YC
authors.lastname: Huang
authors.affiliation: Center of Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Department of Immunology, Faculty of Basic Medical Science, Guilin Medical University, Guilin 541004, China.
authors.forename: Yin-Hui
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Center of Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Department of Immunology, Faculty of Basic Medical Science, Guilin Medical University, Guilin 541004, China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Geng
authors.affiliation: Center of Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Department of Immunology, School of Basic Medicine, Central South University, Changsha, Hunan 410078, China; Department of Immunology, Faculty of Basic Medical Science, Guilin Medical University, Guilin 541004, China.
authors.forename: Hai-Lu
authors.initials: HL
authors.lastname: Zhao
authors.affiliation: Center of Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Department of Immunology, Faculty of Basic Medical Science, Guilin Medical University, Guilin 541004, China. Electronic address: mike-527@163.com.
authors.forename: Xiao-Xi
authors.initials: XX
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6
keywords: Cytokines; Interleukin-6; Meta-analysis; Type 1 diabetes mellitus