title: [Research advances in the pathogenesis of non-alcoholic fatty liver disease-associated liver cancer].
abstract: Nonalcoholic fatty fiver disease (NAFLD) is one of the most common causes of chronic liver disease in clinical practice. It develops from simple fatty liver, nonalcoholic fatty hepatitis to liver fibrosis which may develop liver cirrhosis and result in hepatocellular carcinoma(HCC) eventually. Although studies show that many cell signaling pathways, genes and cell factors are involved in the progression and development of NAFLD related HCC, the exact mechanism underling the pathogenesis of NAFLD-HCC remains poorly understand. Here in this review, we give a summary of the recent findings at home and abroad that describe the epidemiology and pathogenesis of NAFLD associated HCC.
authors.affiliation: Department of Infectious Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: W
authors.initials: W
authors.lastname: Huang
authors.forename: X X
authors.initials: XX
authors.lastname: Zhang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications*; D018450:Disease Progression; D005234:Fatty Liver / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications*; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications*
keywords: Carcinoma, hepatocellular; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis