title: The mazy case of Notch and immunoregulatory cells.
abstract: The Notch pathway represents a conserved signal transduction machinery that is straightforward and based on a few elements (ligands, receptors, transducers). However, the existence of multiple control levels of the Notch signaling final outcome makes it strictly context dependent and dose dependent. The function of Notch as a regulator of cell development and differentiation, as well as the aberrant consequences of its modulation, either positive or negative, is well established. In this review, we will discuss our current knowledge about Notch-dependent regulation of generation and function of 2 subsets of the immunoregulatory system, namely regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). Then, we will focus on an unforeseen mechanism that may unveil an additional way of Notch to govern the surrounding environment in cancer.
authors.affiliation: Department of Experimental Medicine, Sapienza University, Rome, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Grazioli
authors.affiliation: Department of Experimental Medicine, Sapienza University, Rome, Italy.
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Felli
authors.affiliation: Department of Molecular Medicine, Sapienza University, Rome, Italy; and isabella.screpanti@uniroma1.it.|Institute Pasteur Italy-Foundation Cenci Bolognetti, Sapienza University, Rome, Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Screpanti
authors.affiliation: Department of Molecular Medicine, Sapienza University, Rome, Italy; and antonello.campese@uniroma1.it.
authors.forename: Antonio Francesco
authors.initials: AF
authors.lastname: Campese
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D000072737:Myeloid-Derived Suppressor Cells / Q000166:cytology / Q000276:immunology*; D051880:Receptors, Notch / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology*
chemical_list: D051880:Receptors, Notch
keywords: Foxp3; MDSC; T-ALL; Treg