title: Serum neutrophil gelatinase-associated lipocalin has an advantage over serum cystatin C and glomerular filtration rate in prediction of adverse cardiovascular outcome in patients with ST-segment elevation myocardial infarction.
abstract: The aim of this study was to assess significance of serum neutrophil gelatinase-associated lipocalin (sNGAL) and cystatin C (sCC) in prediction of adverse cardiovascular outcome after ST-segment elevation myocardial infarction (STEMI).
  
  
  
  We recruited 357 consecutive patients who were admitted to the hospital within 24 h after onset of STEMI. On the 1st and 12th-14th day after hospital admission, we measured levels of sNGAL and sCC. We also determined presence of renal dysfunction (RD), defined as glomerular filtration rate < 60 mL/min/1.73 m2. After 3 years of follow-up, we performed a logistic regression and assessed the value of RD, sNGAL, and sCC in prediction of combined endpoint, defined as cardiovascular death or any cardiovascular complication.
  
  
  
  RD, sCC level ≥ 1.9 mg/L, and sNGAL level ≥ 1.25 ng/mL on the 12th-14th day of hospitalization were associated with a 1.6-fold, 1.9-fold, and 2.9-fold higher risk of adverse cardiovascular outcome, respectively. Area under the ROC curve was the highest for the model based on sNGAL level compared to the models based on sCC level or RD presence.
  
  
  
  Measurement of sNGAL level in patients with STEMI on the 12th-14th day after hospital admission may improve prediction of adverse cardiovascular outcome.
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, 650002, Kemerovo, Russian Federation.|Kemerovo State Medical University, Voroshilova Street 22a, 650029, Kemerovo, Russian Federation.
authors.forename: Olga L
authors.initials: OL
authors.lastname: Barbarash
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, 650002, Kemerovo, Russian Federation.
authors.forename: Irina S
authors.initials: IS
authors.lastname: Bykova
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, 650002, Kemerovo, Russian Federation.|Kemerovo State Medical University, Voroshilova Street 22a, 650029, Kemerovo, Russian Federation.
authors.forename: Vasiliy V
authors.initials: VV
authors.lastname: Kashtalap
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, 650002, Kemerovo, Russian Federation.
authors.forename: Mikhail V
authors.initials: MV
authors.lastname: Zykov
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, 650002, Kemerovo, Russian Federation.
authors.forename: Oksana N
authors.initials: ON
authors.lastname: Hryachkova
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, 650002, Kemerovo, Russian Federation.
authors.forename: Victoria V
authors.initials: VV
authors.lastname: Kalaeva
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, 650002, Kemerovo, Russian Federation.
authors.forename: Kristina S
authors.initials: KS
authors.lastname: Shafranskaya
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, 650002, Kemerovo, Russian Federation.|Kemerovo State Medical University, Voroshilova Street 22a, 650029, Kemerovo, Russian Federation.
authors.forename: Victoria N
authors.initials: VN
authors.lastname: Karetnikova
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, 650002, Kemerovo, Russian Federation. antonkutikhin@gmail.com.
authors.forename: Anton G
authors.initials: AG
authors.lastname: Kutikhin
mesh_terms: D015415:Biomarkers / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D015994:Incidence; D000071068:Lipocalin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D051437:Renal Insufficiency / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000401:mortality; D012800:Siberia / Q000453:epidemiology; D015996:Survival Rate / Q000639:trends; D013997:Time Factors
chemical_list: D015415:Biomarkers; D055316:Cystatin C; C489506:LCN2 protein, human; D000071068:Lipocalin-2
keywords: Cystatin C; Glomerular filtration rate; Neutrophil gelatinase-associated lipocalin; Renal dysfunction; ST-segment elevation myocardial infarction