title: Translational applications of adult stem cell-derived organoids.
abstract: Adult stem cells from a variety of organs can be expanded long-termin vitroas three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from patient-derived healthy and diseased tissue allows for the study of organ development, tissue homeostasis and disease. In this Review, we discuss the generation of adult stem cell-derived organoid cultures and their applications inin vitrodisease modeling, personalized cancer therapy and regenerative medicine.
authors.affiliation: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht 3584CT, The Netherlands.|Cancer Genomics Netherlands, UMC Utrecht, Utrecht 3584CG, The Netherlands.
authors.forename: Jarno
authors.identifier: 0000-0002-2941-6179
authors.initials: J
authors.lastname: Drost
authors.affiliation: Cancer Genomics Netherlands, UMC Utrecht, Utrecht 3584CG, The Netherlands.|Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht 3584CT, The Netherlands h.clevers@hubrecht.eu.|Princess Máxima Center for Pediatric Oncology, Utrecht 3584CT, The Netherlands.
authors.forename: Hans
authors.identifier: 0000-0002-3077-5582
authors.initials: H
authors.lastname: Clevers
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology*; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D009940:Organoids / Q000166:cytology*; D057285:Precision Medicine; D044968:Regenerative Medicine; D057170:Translational Research, Biomedical
keywords: Adult stem cells; Cancer; Disease modelling; Organoids