title: Association between diabetes mellitus and incidence of intracerebral haemorrhage and case fatality rates: A retrospective population-based cohort study.
abstract: We investigated the associations between diabetes (type 1, type 2 or no diabetes) and intracerebral haemorrhage (ICH) incidence as well as case fatality after ICH, in a retrospective cohort study of people aged 40 to 89 years in Scotland during the period 2004 to 2013, using linkage of population-based records of diagnosed diabetes, hospital discharges and deaths. We calculated ICH incidence and 30-day case fatality after hospital admission for ICH, along with their relative risks (RR) and 95% confidence intervals (CIs), among people with type 1 or type 2 diabetes compared to people without diabetes, adjusting for age, sex and socio-economic status (SES). There were 77, 1275 and 9778 incident ICH events and the case-fatality rate was 44% (95% CI 33, 57), 38% (95% CI 35, 41) and 36% (95% CI 35, 37) in people with type 1, type 2 and without diabetes, respectively. In comparison with absence of diabetes, type 1 diabetes was associated with a higher incidence of ICH (1.74, 95% CI 1.38-2.21) and higher case fatality after ICH (1.35, 95% CI 1.01-1.70), after adjustment for age, sex and SES. The small increases in ICH incidence (1.06, 95% CI 0.99-1.12) and case-fatality (1.04, 95% CI 0.96-1.13) in people with type 2 diabetes compared with people without diabetes were not statistically significant.
authors.affiliation: Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.|Normandy University, UNICAEN, CHU Côte de Nacre, Neurology Service, Caen, France.
authors.forename: Marion
authors.identifier: 0000-0003-0900-1766
authors.initials: M
authors.lastname: Boulanger
authors.affiliation: Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
authors.forename: Rustam
authors.initials: R
authors.lastname: Al-Shahi Salman
authors.affiliation: Information Services Division, NHS National Services Scotland, Edinburgh, UK.
authors.forename: Jan
authors.initials: J
authors.lastname: Kerssens
authors.affiliation: Usher Institute for Population Health Sciences and Informatics, Medical School, University of Edinburgh, Edinburgh, UK.
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Wild
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000401:mortality; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000401:mortality; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D003929:Diabetic Neuropathies / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009026:Mortality; D012042:Registries; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors; D012606:Scotland / Q000453:epidemiology
keywords: case fatality; epidemiology; haemorrhagic stroke; incidence; intracerebral haemorrhage; risk factors; type 1 diabetes; type 2 diabetes