title: [Autism spectrum disorder: Etiological, diagnostic and therapeutic aspects].
abstract: Autism spectrum disorder (ASD) was described for the first time in 1943 by Leo Kanner, and since 2004, 18 490 articles in the subject have been published, which in turn have been cited 48 416 times.1 Almost half of these publications come from the United States of America and the vast maority of the efforts to improve the quality of life of these patients have taken place in developed countries. This disorder consists of an inability to acquire social and emotional skills during early development that progressively results in variable degrees of social adaptation discapacity. The etiology is multifactorial and includes functional and structural neurological abnormalities, some of them with putative genetic and/or epigenetic origin. There is an alarming lack of knowledge in the subject among health care professionals. The purpose of this systematic review is to summarize the most relevant historical, diagnostic and therapeutic aspects of ASD.
authors.affiliation: Departamentos de Neuropediatría, Centro Neurológico, Centro Médico American Birtish Cowdray, Ciudad de México, México. cealreflo@gmail.com.
authors.forename: César
authors.initials: C
authors.lastname: Reynoso
authors.forename: María José
authors.initials: MJ
authors.lastname: Rangel
authors.forename: Virgilio
authors.initials: V
authors.lastname: Melgar
mesh_terms: D000067877:Autism Spectrum Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D002491:Central Nervous System Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018479:Early Intervention, Educational / Q000379:methods; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D011379:Prognosis; D011613:Psychotherapy / Q000379:methods; D012307:Risk Factors
chemical_list: D002491:Central Nervous System Agents
keywords: Asperger syndrome; Autistic disorder; Neurodevelopmental disorders; Pervasive child development disorders