title: Metal artifact reduction in MRI-based cervical cancer intracavitary brachytherapy.
abstract: Magnetic resonance imaging (MRI) plays an increasingly important role in brachytherapy planning for cervical cancer. Yet, metal tandem, ovoid intracavitary applicators, and fiducial markers used in brachytherapy cause magnetic susceptibility artifacts in standard MRI. These artifacts may impact the accuracy of brachytherapy treatment and the evaluation of tumor response by misrepresenting the size and location of the metal implant, and distorting the surrounding anatomy and tissue. Metal artifact reduction sequences (MARS) with high bandwidth RF selective excitations and turbo spin-echo readouts were developed for MRI of orthopedic implants. In this study, metal artifact reduction was applied to brachytherapy of cervical cancer using the orthopedic metal artifact reduction (O-MAR) sequence. O-MAR combined MARS features with view angle tilting and slice encoding for metal artifact correction (SEMAC) to minimize in-plane and through-plane susceptibility artifacts. O-MAR improved visualization of the tandem tip on T2and proton density weighted (PDW) imaging in phantoms and accurately represented the diameter of the tandem. In a pilot group of cervical cancer patients (N  =  7), O-MAR significantly minimized the blooming artifact at the tip of the tandem in PDW MRI. There was no significant difference observed in artifact reduction between the weak (5 kHz, 7 z-phase encodes) and medium (10 kHz, 13 z-phase encodes) SEMAC settings. However, the weak setting allowed a significantly shorter acquisition time than the medium setting. O-MAR also reduced susceptibility artifacts associated with metal fiducial markers so that they appeared on MRI at their true dimensions.
authors.affiliation: Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, United States of America.
authors.forename: Yuan James
authors.initials: YJ
authors.lastname: Rao
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Zoberi
authors.forename: Mo
authors.initials: M
authors.lastname: Kadbi
authors.forename: Perry W
authors.initials: PW
authors.lastname: Grigsby
authors.forename: Jochen
authors.initials: J
authors.lastname: Cammin
authors.forename: Stacie L
authors.initials: SL
authors.lastname: Mackey
authors.forename: Jose
authors.initials: J
authors.lastname: Garcia-Ramirez
authors.forename: S Murty
authors.initials: SM
authors.lastname: Goddu
authors.forename: Julie K
authors.initials: JK
authors.lastname: Schwarz
authors.forename: H Michael
authors.initials: HM
authors.lastname: Gach
mesh_terms: D016477:Artifacts; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D057918:Fiducial Markers / Q000592:standards; D006801:Humans; D007089:Image Enhancement / Q000379:methods* / Q000592:standards; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D008670:Metals / Q000009:adverse effects; D019047:Phantoms, Imaging; D019736:Prostheses and Implants / Q000009:adverse effects*; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*
chemical_list: D008670:Metals