title: Anti-Müllerian hormone concentrations and parity in fertile women: the model of oocyte donors.
abstract: In France until the end of 2015, oocyte donors must have had at least one child and be aged 18-37 years. This population of fertile women was selected to examine whether serum anti-Müllerian hormone (AMH) concentration could be a reliable correlate of spontaneous pregnancy in women who had proven their fertility before. A cohort of 217 women followed between 2009 and 2015 for oocyte donation at the University Hospital of Lille comprised this retrospective study. In these egg donors, aged 20-37 (median: 32 years), the median serum AMH level was 22 pmol/l (5-95th percentiles: 4.9-61.8). No significant correlation was found between serum AMH level and the number of children or the youngest child's age. Among the 32 women with AMH <10 pmol/l, 9 and 3 were less than 30 and 25 years old, respectively. Six women (2.8%) had undetectable serum AMH, i.e. <3 pmol/l. In conclusion, serum AMH level measured in this fertile female cohort showed too much variability to be a good fertility index. Assessment of serum AMH should only be discussed for patients at risk of ovarian failure.
authors.affiliation: Department of Endocrine Gynaecology and Reproductive Medicine, CHU Lille, Univ. Lille, F-59000 Lille, France; INSERM U1172 Team 2, JPARC, Univ. Lille, F-59000 Lille, France. Electronic address: sophie.jonard@chru-lille.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Catteau-Jonard
authors.affiliation: Department of Endocrine Gynaecology and Reproductive Medicine, CHU Lille, Univ. Lille, F-59000 Lille, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Roux
authors.affiliation: Department of Endocrine Gynaecology and Reproductive Medicine, CHU Lille, Univ. Lille, F-59000 Lille, France.
authors.forename: Agathe
authors.initials: A
authors.lastname: Dumont
authors.affiliation: Department of Endocrine Gynaecology and Reproductive Medicine, CHU Lille, Univ. Lille, F-59000 Lille, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Delesalle
authors.affiliation: Department of Endocrine Gynaecology and Reproductive Medicine, CHU Lille, Univ. Lille, F-59000 Lille, France.
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Robin
authors.affiliation: Department of Endocrine Gynaecology and Reproductive Medicine, CHU Lille, Univ. Lille, F-59000 Lille, France; INSERM U1172 Team 2, JPARC, Univ. Lille, F-59000 Lille, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Dewailly
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005298:Fertility; D006801:Humans; D007700:Kinetics; D011247:Pregnancy
chemical_list: D054304:Anti-Mullerian Hormone
keywords: Anti-Müllerian hormone; fertile women; oocyte donors; parity; spontaneous pregnancy