title: Clinical Significance and Prognosis Value of Wnt Signaling Pathway in Cervical Cancer.
abstract: Cervical cancer is among the most commonly diagnosed cancer in women, supporting the need for identification of novel prognostic and predictive biomarkers to predict the risk of developing of this malignancy or predict the prognosis of patients. Against this background, the activation of the Wingless-type (Wnt)/β-catenin pathway has been suggested as the main dysregulated pathways, which is involved in the multistep process of cervical carcinogenesis, suggesting its value as a potential biomarker or therapeutic target. The aim of current review is to give an overview about the potential application of WNT pathway and its value which is differentially expressed in cervical cancer versus non-tumorigenic tissue as biomarker for risk stratification and predict the prognosis of patients with cervical cancer. J. Cell. Biochem. 118: 3028-3033, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Afsane
authors.initials: A
authors.lastname: Bahrami
authors.affiliation: Department of Gynecology Oncology, Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Malihe
authors.initials: M
authors.lastname: Hasanzadeh
authors.affiliation: Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Soodabeh
authors.initials: S
authors.lastname: ShahidSales
authors.affiliation: Department of Gynecology Oncology, Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Zohre
authors.initials: Z
authors.lastname: Yousefi
authors.affiliation: Department of Gynecology Oncology, Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Sima
authors.initials: S
authors.lastname: Kadkhodayan
authors.affiliation: Department of Gynecology Oncology, Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Marjaneh
authors.initials: M
authors.lastname: Farazestanian
authors.affiliation: Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mona
authors.initials: M
authors.lastname: Joudi Mashhad
authors.affiliation: Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Gharib
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Seyed
authors.identifier: 0000-0002-5247-4043
authors.initials: S
authors.lastname: Mahdi Hassanian
authors.affiliation: Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amir
authors.identifier: 0000-0002-4968-0962
authors.initials: A
authors.lastname: Avan
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D011379:Prognosis; D018570:Risk Assessment; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D060449:Wnt Signaling Pathway
chemical_list: D014408:Biomarkers, Tumor
keywords: CERVICAL CANCER; PATIENTS; WNT PATHWAY