title: The effects of retinoic acid on mitosis during tail and limb regeneration in the axolotl larva, Ambystoma mexicanum.
abstract: Regenerating tails and limbs of axolotl larvae (A. mexicanum) were studied for overall growth and for mitosis after the animals received intraperitoneal injections of all-trans retinoic acid. Both processes were depressed to approximately the same extent (60-70%). Some mitosis always survived, even when the treatment was in effect during the entire history of the regenerate. The treatment duration was a major variable in the severity of the effect, whereas the post-amputation age of the regenerate was not. In limb regenerates the epithelial cap and the mesenchymal blastema were affected to roughly the same degree.
authors.affiliation: Department of Visual Sciences, School of Optometry and the Medical Sciences Program, School of Medicine, Indiana University, 47405, Bloomington, Indiana, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Pietsch
keywords: Ambystoma mexicanum; Regeneration; Retinoic acid; Retinoids; Vitamin A