title: Overview of iron metabolism in health and disease.
abstract: Iron is an essential element for numerous fundamental biologic processes, but excess iron is toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney disease and iron administration is a mainstay of anemia management in many patients. This review provides an overview of the essential role of iron in biology, the regulation of systemic and cellular iron homeostasis, how imbalances in iron homeostasis contribute to disease, and the implications for chronic kidney disease patients.
authors.affiliation: Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Som
authors.initials: S
authors.lastname: Dev
authors.affiliation: Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Jodie L
authors.initials: JL
authors.lastname: Babitt
mesh_terms: D002318:Cardiovascular Diseases / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D000090463:Iron Deficiencies; D019190:Iron Overload / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000378:metabolism
chemical_list: D007501:Iron
keywords: Iron metabolism; anemia; chronic kidney disease; iron deficiency; iron overload