title: Increased risk of essential tremor in migraine: A population-based retrospective cohort study.
abstract: OBJECTIVE
  To examine the long-term risk of essential tremor (ET) in migraine.
  
  
  METHODS
  Using population-based administrative data from a subset of the National Health Insurance Research Database (NHIRD) of Taiwan, we identified 22,696 newly diagnosed migraineurs (mean age 44.5 years) and a matched migraine-free cohort of 90,784 individuals in the period 2000-2008. Multivariable Cox proportional hazards regression analysis was conducted for assessing the ET risk for the migraine cohort compared to the migraine-free cohort.
  
  
  RESULTS
  After adjusting for covariates, the migraine cohort had a 1.83-fold increased risk (95% CI 1.50-2.23) of subsequent ET in comparison to the migraine-free cohort (8.97 vs. 4.81 per 10,000 person-years). In the subgroup analysis, patients with migraine were associated with higher risks of ET, regardless of gender, age or the existence of comorbidities.
  
  
  CONCLUSIONS
  Our findings demonstrated an association between migraine and ET, suggesting a possible shared pathophysiology underpinning both disorders.
authors.affiliation: Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.|Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.|Institute of Cognitive Neuroscience, University College London, Queen Square, London, United Kingdom.|College of Medicine, Fu-Jen Catholic University, Taipei, Taiwan.
authors.forename: Chi-Ieong
authors.initials: CI
authors.lastname: Lau
authors.affiliation: Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.|Healthcare Service Research Center (HSRC), Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Che-Chen
authors.initials: CC
authors.lastname: Lin
authors.affiliation: Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.|College of Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Hsuan-Ju
authors.initials: HJ
authors.lastname: Chen
authors.affiliation: Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.|College of Medicine, Taipei Medical University, Taipei, Taiwan.|College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Han-Cheng
authors.initials: HC
authors.lastname: Wang
authors.affiliation: Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.|College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Wei-Hung
authors.initials: WH
authors.lastname: Chen
authors.affiliation: Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.|Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Ji-An
authors.identifier: http://orcid.org/0000-0002-4170-7155
authors.initials: JA
authors.lastname: Liang
mesh_terms: D015331:Cohort Studies; D020329:Essential Tremor / Q000150:complications*; D006801:Humans; D008881:Migraine Disorders / Q000150:complications*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013624:Taiwan