title: Nutrients and the Pancreas: An Epigenetic Perspective.
abstract: Pancreatic cancer is the fourth most common cause of cancer-related deaths with a dismal average five-year survival rate of six percent. Substitutional progress has been made in understanding how pancreatic cancer develops and progresses. Evidence is mounting which demonstrates that diet and nutrition are key factors in carcinogenesis. In particular, diets low in folate and high in fruits, vegetables, red/processed meat, and saturated fat have been identified as pancreatic cancer risk factors with a proposed mechanism involving epigenetic modifications or gene regulation. We review the current literature assessing the correlation between diet, epigenetics, and pancreatic cancer.
authors.affiliation: Department of Public Health, North Dakota State University, Fargo, ND 58102, USA. andee.weisbeck@ndsu.edu.
authors.forename: Andee
authors.initials: A
authors.lastname: Weisbeck
authors.affiliation: Department of Public Health, North Dakota State University, Fargo, ND 58102, USA. rick.jansen@ndsu.edu.
authors.forename: Rick J
authors.initials: RJ
authors.lastname: Jansen
mesh_terms: D004032:Diet; D044127:Epigenesis, Genetic; D005227:Fatty Acids / Q000008:administration & dosage / Q000009:adverse effects; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood; D005638:Fruit; D006801:Humans; D008461:Meat Products / Q000009:adverse effects / Q000032:analysis; D018977:Micronutrients / Q000008:administration & dosage* / Q000097:blood / Q000172:deficiency; D009752:Nutritional Status; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000235:genetics / Q000517:prevention & control; D000069466:Red Meat / Q000009:adverse effects / Q000032:analysis; D012307:Risk Factors; D014675:Vegetables
chemical_list: D005227:Fatty Acids; D018977:Micronutrients; D005492:Folic Acid
keywords: epigenetics; nutrition; pancreatic cancer