title: Rapid adiposity growth increases risks of new-onset asthma and airway inflammation in children.
abstract: We aim to (1) examine the influence of long-term adiposity status/short-term adiposity changes on asthma with high or low fractional exhaled nitric oxide (FeNO), and (2) to determine the differences in long-term adiposity status/short-term adiposity changes on atopy, airway inflammation and pulmonary function.
  
  
  
  We recruited 2450 fourth- to sixth-grade children from the nationwide Taiwan Children Health Study. Data regarding various adiposity indicators, atopic status, pulmonary function tests and asthma outcomes were collected annually. New-onset asthma was stratified by airway inflammation status using FeNO. The generalized estimating equation was used for analyzing longitudinal relationships between long-term adiposity status/short-term adiposity changes and new-onset asthma. Individual adiposity growth slopes were obtained using a hierarchical linear model to establish the relationships between short-term adiposity changes and asthma among children with high airway inflammation.
  
  
  
  We found long-term adiposity status predicted childhood asthma with low FeNO, whereas short-term adiposity changes may increase risks of childhood asthma with high FeNO. Long-term adiposity status reduced pulmonary function, whereas short-term adiposity increase were associated with atopic diseases and airway inflammation.
  
  
  
  Obesity-induced asthma could be mediated by high or low airway inflammation, depending on the velocity of increase in adiposity. Rapid adiposity growth may increase risks of childhood asthma and airway inflammation.
authors.affiliation: Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan.|School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.
authors.forename: Y-C
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.|Health Center, Office of Student Affairs, National Taiwan University, Taipei, Taiwan.
authors.forename: A-H
authors.initials: AH
authors.lastname: Chih
authors.affiliation: School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.
authors.forename: J-R
authors.initials: JR
authors.lastname: Chen
authors.affiliation: Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan.
authors.forename: T-H
authors.initials: TH
authors.lastname: Liou
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: W-H
authors.initials: WH
authors.lastname: Pan
authors.affiliation: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.|Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: Y L
authors.initials: YL
authors.lastname: Lee
mesh_terms: D050154:Adiposity / Q000276:immunology; D000293:Adolescent; D001249:Asthma / Q000503:physiopathology* / Q000517:prevention & control; D015992:Body Mass Index; D001944:Breath Tests; D002648:Child; D015897:Comorbidity; D015444:Exercise; D045853:Exhalation; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology* / Q000517:prevention & control; D033183:Interdisciplinary Communication; D008137:Longitudinal Studies; D008297:Male; D009569:Nitric Oxide / Q000032:analysis; D063766:Pediatric Obesity / Q000150:complications / Q000503:physiopathology* / Q000517:prevention & control; D010809:Physical Fitness / Q000502:physiology; D013624:Taiwan / Q000453:epidemiology; D015431:Weight Loss / Q000502:physiology
chemical_list: D009569:Nitric Oxide