title: Neutrophil to Lymphocyte Ratio as a predictor of early penile prosthesis implant infection.
abstract: OBJECTIVE
  To investigate the predictive value of preoperative serum neutrophil-to-lymphocyte ratio (NLR) on the development of postoperative infections in patients undergoing penile prosthesis implantation (PPI).
  
  
  METHODS
  We retrospectively analyzed the data of 361 patients who underwent PPI over a 4-year period with at least 1-year follow-up. Demographics, blood results, and postoperative 1-year complications were recorded. Recommended cutoff values of NLR for early postoperative infectious complications were determined using receiver operating characteristic analysis.
  
  
  RESULTS
  A total of 153 patients with the mean age of 56.4 ± 8 years were included in the study. Mean follow-up time was 56.7 ± 30.4 months (12-108 months). Early postoperative infectious complications were occured in 18 patients (11.8%). These infections were prosthesis infection in 8 patients (5.2%), wound infection in 6 patients (3.9%), and urinary tract infection in 4 patients (2.6%). All these complications were occured within the first year of the surgery. Mean NLR was statistically higher in patients with postoperative complications when compared with uncomplicated cases (7.2 ± 3.9 vs. 2.2 ± 1.4, p < 0.001, respectively) Using a cut point of 6.2, preoperative NLR predicted postoperative complications with a sensitivity of 67% and specificity of 99%.
  
  
  CONCLUSIONS
  This study is the first to investigate the relationship between NLR and early postoperative infection as a complication of PPI. The results demonstrated that the NLR value could be a potential laboratory parameter for predicting early postoperative infectious complications in patients undergoing PPI.
authors.affiliation: Department of Urology, Izmir Bozyaka Training and Research Hospital, Saim Cikrikci Street, No: 59, 35170, Karabaglar, Izmir, Turkey. drbolat@hotmail.com.
authors.forename: Deniz
authors.initials: D
authors.lastname: Bolat
authors.affiliation: Department of Urology, Izmir Bozyaka Training and Research Hospital, Saim Cikrikci Street, No: 59, 35170, Karabaglar, Izmir, Turkey.
authors.forename: Yusuf Kadir
authors.initials: YK
authors.lastname: Topcu
authors.affiliation: Department of Urology, Izmir Bozyaka Training and Research Hospital, Saim Cikrikci Street, No: 59, 35170, Karabaglar, Izmir, Turkey.
authors.forename: Ozgu
authors.initials: O
authors.lastname: Aydogdu
authors.affiliation: Department of Urology, Izmir Bozyaka Training and Research Hospital, Saim Cikrikci Street, No: 59, 35170, Karabaglar, Izmir, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Minareci
authors.affiliation: Department of Urology, Izmir Bozyaka Training and Research Hospital, Saim Cikrikci Street, No: 59, 35170, Karabaglar, Izmir, Turkey.
authors.forename: Cetin
authors.initials: C
authors.lastname: Dincel
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes; D008875:Middle Aged; D009504:Neutrophils; D015917:Penile Prosthesis / Q000009:adverse effects*; D011237:Predictive Value of Tests; D057234:Preoperative Period; D019919:Prosthesis Implantation / Q000009:adverse effects*; D016459:Prosthesis-Related Infections / Q000097:blood* / Q000209:etiology; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000097:blood* / Q000209:etiology; D014552:Urinary Tract Infections / Q000097:blood* / Q000209:etiology
chemical_list: D015415:Biomarkers
keywords: Biomarker; Complication; Infection; Inflammation; Neutrophil-to-lymphocyte ratio; Penile prosthesis