title: Twenty-Four-Hour Real-Time Continuous Monitoring of Cerebral Edema in Rabbits Based on a Noninvasive and Noncontact System of Magnetic Induction.
abstract: Cerebral edema is a common disease, secondary to craniocerebral injury, and real-time continuous monitoring of cerebral edema is crucial for treating patients after traumatic brain injury. This work established a noninvasive and noncontact system by monitoring the magnetic induction phase shift (MIPS) which is associated with brain tissue conductivity. Sixteen rabbits (experimental groupn= 10, control group,n= 6) were used to perform a 24 h MIPS and intracranial pressure (ICP) simultaneously monitored experimental study. For the experimental group, after the establishment of epidural freeze-induced cerebral edema models, the MIPS presented a downward trend within 24 h, with a change magnitude of -13.1121 ± 2.3953°; the ICP presented an upward trend within 24 h, with a change magnitude of 12-41 mmHg. The ICP was negatively correlated with the MIPS. In the control group, the MIPS change amplitude was -0.87795 ± 1.5146 without obvious changes; the ICP fluctuated only slightly at the initial value of 12 mmHg. MIPS had a more sensitive performance than ICP in the early stage of cerebral edema. These results showed that this system is basically capable of monitoring gradual increases in the cerebral edema solution volume. To some extent, the MIPS has the potential to reflect the ICP changes.
authors.affiliation: College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China. calvin_gen@163.com.|College of Bioengineering, Chongqing University, Chongqing 400030, China. calvin_gen@163.com.
authors.forename: Gen
authors.initials: G
authors.lastname: Li
authors.affiliation: College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China. ywqmk@sohu.com.
authors.forename: Ke
authors.initials: K
authors.lastname: Ma
authors.affiliation: College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China. nksunj@126.com.|Department of Neurosurgery, Southwest Hospital, Chongqing 400038, China. nksunj@126.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.affiliation: College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China. tjjingui@126.com.
authors.forename: Gui
authors.initials: G
authors.lastname: Jin
authors.affiliation: College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China. qmingxin@tmmu.edu.cn.
authors.forename: Mingxin
authors.initials: M
authors.lastname: Qin
authors.affiliation: Department of Neurosurgery, Southwest Hospital, Chongqing 400038, China. fenghua_swh@sina.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Feng
mesh_terms: D000818:Animals; D001921:Brain; D001929:Brain Edema; D007427:Intracranial Pressure; D008991:Monitoring, Physiologic; D055585:Physical Phenomena; D011817:Rabbits
keywords: cerebral edema; intracranial pressure; magnetic induction; noncontact; real-time monitoring