title: Antibacterial, antifungal, and antiviral effects of three essential oil blends.
abstract: New agents that are effective against common pathogens are needed particularly for those resistant to conventional antimicrobial agents. Essential oils (EOs) are known for their antimicrobial activity. Using the broth microdilution method, we showed that (1) two unique blends of Cinnamomum zeylanicum, Daucus carota, Eucalyptus globulus and Rosmarinus officinalis EOs (AB1 and AB2; cinnamon EOs from two different suppliers) were active against the fourteen Gram-positive and -negative bacteria strains tested, including some antibiotic-resistant strains. Minimal inhibitory concentrations (MICs) ranged from 0.01% to 3% v/v with minimal bactericidal concentrations from <0.01% to 6.00% v/v; (2) a blend of Cinnamomum zeylanicum, Daucus carota, Syzygium aromaticum, Origanum vulgare EOs was antifungal to the six Candida strains tested, with MICs ranging from 0.01% to 0.05% v/v with minimal fungicidal concentrations from 0.02% to 0.05% v/v. Blend AB1 was also effective against H1N1 and HSV1 viruses. With this dual activity, against H1N1 and against S. aureus and S. pneumoniae notably, AB1 may be interesting to treat influenza and postinfluenza bacterial pneumonia infections. These blends could be very useful in clinical practice to combat common infections including those caused by microorganisms resistant to antimicrobial drugs.
authors.affiliation: PiLeJe, Paris Cedex 15, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Brochot
authors.affiliation: PiLeJe, Paris Cedex 15, France.
authors.forename: Angèle
authors.initials: A
authors.lastname: Guilbot
authors.affiliation: Fonderephar, Toulouse Cedex 09, France.
authors.forename: Laïla
authors.initials: L
authors.lastname: Haddioui
authors.affiliation: Fonderephar, Toulouse Cedex 09, France.|Laboratoire de Génie Chimique UMR 5503, Faculté des Sciences Pharmaceutiques, Université Paul Sabatier, Toulouse, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Roques
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry*; D014780:Viruses / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D009822:Oils, Volatile
keywords: 
  E. coli
  ; Fungi; antimicrobials; infection; viruses