title: The role of Notch signalling in ovarian angiogenesis.
abstract: In adults, the ovary is characterized with extensive angiogenesis and regular intervals of rapid growth. Ovarian function is dependent on the network of angiogenic vessels which enable the follicle and/or corpus luteum to receive oxygen, nutrients and hormonal support. Abnormal angiogenesis is involved in the induction and development of pathological ovary, such as polycystic ovary syndrome and ovarian cancer. Notch signalling pathway is one of the primary regulators of angiogenesis and a therapeutic target for ovarian diseases. Here, we will review literatures on the expression pattern of Notch pathway components in the ovary and on the role of Notch signalling pathway on ovarian angiogenesis.
authors.affiliation: Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Taishan Medical College, Taian, People's Republic of China.
authors.forename: Zuowang
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan, People's Republic of China.
authors.forename: Xiaocui
authors.initials: X
authors.lastname: Chen
authors.affiliation: Molecular and Cellular Biology Division, Sunnybrook Health Science Centre, University of Toronto, Toronto, ON, Canada.|Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
authors.forename: Corrinne G
authors.initials: CG
authors.lastname: Lobe
authors.affiliation: Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan, People's Republic of China. ju.liu@sdu.edu.cn.
authors.forename: Ju
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D058990:Molecular Targeted Therapy; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000235:genetics; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D010053:Ovary / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D051880:Receptors, Notch / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D051880:Receptors, Notch
keywords: Angiogenesis; Dll4; Jagged 1; Nitric Oxide; Notch signalling pathway; Ovarian cancer; Polycystic ovary syndrome; VEGF