title: Absolute Stereochemical Determination of Asymmetric Sulfoxides via Central to Axial Induction of Chirality.
abstract: The absolute configuration of chiral sulfoxides is determined by means of host-guest complexation that leads to the induction of axial chirality in an achiral host. The central to axial induction of helicity is rationalized by a simple recognition of the relative length and size of the substituents attached to the S-center. This technique is used to determine the absolute configuration of chiral sulfoxides, requiring micrograms of sample, without the need for prefunctionalization.
authors.affiliation: Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United States.
authors.forename: Hadi
authors.identifier: 0000-0001-6520-0845
authors.initials: H
authors.lastname: Gholami
authors.affiliation: Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United States.
authors.forename: Jun
authors.identifier: 0000-0002-9986-0312
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United States.
authors.forename: Mercy
authors.initials: M
authors.lastname: Anyika
authors.affiliation: Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United States.
authors.forename: Babak
authors.identifier: 0000-0002-3193-0732
authors.initials: B
authors.lastname: Borhan