title: Roles of RUNX in Hippo Pathway Signaling.
abstract: The Runt-domain (RD) transcription factors (RUNX genes) are an important family of transcriptional mediators that interact with a variety of proteins including the Hippo pathway effector proteins, YAP and TAZ. In this chapter we focus on two examples of RUNX-TAZ/YAP interactions that have particular significance in human cancer. Specifically, recent evidence has found that RUNX2 cooperates with TAZ to promote epithelial to mesenchymal transition mediated by the soluble N-terminal ectodomain of E-Cadherin, sE-Cad. Contrastingly, in gastric cancer, RUNX3 acts as a tumor suppressor via inhibition of the YAP-TEAD complex and disruption of downstream YAP-mediated gene transcription and the oncogenic phenotype. The reports highlighted in this chapter add to the growing repertoire of instances of Hippo pathway crosstalk that have been identified in cancer. Elucidation of these increasingly complex interactions may help to identify novel strategies to target Hippo pathway dysregulation in human cancer.
authors.affiliation: Department of Pathology and Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, and the Veterans Administration Health Service, Baltimore, MD, USA. TPassaniti@som.umaryland.edu.
authors.forename: Antonino
authors.initials: A
authors.lastname: Passaniti
authors.affiliation: Department of Pathology and Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, and the Veterans Administration Health Service, Baltimore, MD, USA.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Brusgard
authors.affiliation: The Mechanobiology Institute (MBI) and the NUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.
authors.forename: Yiting
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: The Mechanobiology Institute (MBI) and the NUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.|Institute of Molecular and Cell Biology A*STAR, Singapore, Republic of Singapore.
authors.forename: Marius
authors.initials: M
authors.lastname: Sudol
authors.affiliation: The Mechanobiology Institute (MBI) and the NUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.
authors.forename: Megan
authors.initials: M
authors.lastname: Finch-Edmondson
mesh_terms: D000818:Animals; D050657:Core Binding Factor alpha Subunits / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D050657:Core Binding Factor alpha Subunits; D025521:Tumor Suppressor Proteins; D017346:Protein Serine-Threonine Kinases
keywords: Breast cancer; Gastric cancer; Hippo pathway; RUNX proteins; TAZ; TEAD; YAP; sE-Cad