title: Biliary reconstruction in liver transplant patients with primary sclerosing cholangitis, duct-to-duct or Roux-en-Y?
abstract: Roux-en-Y choledochojejunostomy and duct-to-duct (D-D) anastomosis are biliary reconstruction methods for liver transplantation. However, there is a controversy over which method produces better results. We have compared the outcome of D-D anastomosis vs. Roux-en-Y hepaticojejunostomy in patients with primary sclerosing cholangitis who had undergone liver transplant in Shiraz Organ Transplant Center.
  
  
  
  The medical records of 405 patients with primary sclerosing cholangitis (PSC) who had undergone liver transplant from 1996 to 2015 were reviewed. Patients were divided into two groups: Roux-en-Y group and D-D group. Morbidity, disease recurrence, and graft and patient survival rates were compared between the two groups.
  
  
  
  Total of 143 patients underwent a D-D biliary reconstruction, and 260 patients had a Roux-en-Y loop. Biliary complication involved 4.2% of patients from the D-D group, and 3.9% from the Roux-en-Y group (P=. 863). Actuarial 1-, 3-, and 5-year patient survival for D-D and Roux-en-Y group was 92%, 85%, and 74%; and 87%, 83%, and 79%, respectively (P=.384). The corresponding 1-, 3-, and 5-year probability of biliary complication was 97%, 95%, and 92%; and 98%, 97%, and 94%, respectively (P=.61).
  
  
  
  Duct-to-duct biliary reconstruction in liver transplantation for selected patients with PSC is a good alternative instead of Roux-en-Y biliary reconstruction.
authors.affiliation: Shiraz Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Shamsaeefar
authors.affiliation: Shiraz Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shafiee
authors.affiliation: Shiraz Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Saman
authors.initials: S
authors.lastname: Nikeghbalian
authors.affiliation: Shiraz Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Kourosh
authors.initials: K
authors.lastname: Kazemi
authors.affiliation: Shiraz Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohsenreza
authors.initials: M
authors.lastname: Mansorian
authors.affiliation: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Nasrin
authors.identifier: 0000-0001-9534-4014
authors.initials: N
authors.lastname: Motazedian
authors.affiliation: Division of Nephrology, Department of Internal Medicine, University of ‎Michigan, Ann Arbor, Michigan.
authors.forename: Farsad
authors.initials: F
authors.lastname: Afshinnia
authors.affiliation: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Bita
authors.initials: B
authors.lastname: Geramizadeh
authors.affiliation: Shiraz Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Malekhosseini
mesh_terms: D000328:Adult; D000713:Anastomosis, Roux-en-Y / Q000379:methods*; D001662:Biliary Tract Surgical Procedures; D015209:Cholangitis, Sclerosing / Q000601:surgery*; D002768:Choledochostomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D011379:Prognosis; D019651:Plastic Surgery Procedures; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Roux-en-Y; duct-to-duct; primary sclerosing cholangitis; transplantation