title: Curcumin Nanotechnologies and Its Anticancer Activity.
abstract: Cancer is one of the leading causes of death worldwide. Curcumin is a well-established anticancer agent in vitro but its efficacy is yet to be proven in clinical trials. Poor bioavailability of curcumin is the principal reason behind the lack of efficiency of curcumin in clinical trials. Many studies prove that the bioavailability of curcumin can be improved by administering it through nanoparticle drug carriers. This review focuses on the efforts made in the field of nanotechnology to improve the bioavailability of curcumin. Nanotechnologies of curcumin come in various shapes and sizes. The simplest curcumin nanoparticle that increased the bioavailability of curcumin is the curcumin-metal complex. On the other hand, we have intricate thermoresponsive nanoparticles that can release curcumin upon stimulation (analogous to a remote control). Future research required for developing potent curcumin nanoparticles is also discussed.
authors.affiliation: a Department of Zoology , Yogi Vemana University , Kadapa , India.|b Centre for Fish Immunology, School of Life Sciences , Vels Institute of Science Technology and Advanced Studies , Chennai , India.
authors.forename: Parasuraman Aiya
authors.initials: PA
authors.lastname: Subramani
authors.affiliation: c Department of Biotechnology , Govt. College for Men , Kadapa , India.
authors.forename: Kalpana
authors.initials: K
authors.lastname: Panati
authors.affiliation: a Department of Zoology , Yogi Vemana University , Kadapa , India.
authors.forename: Venkata Ramireddy
authors.initials: VR
authors.lastname: Narala
mesh_terms: D000336:Aerosols / Q000737:chemistry / Q000493:pharmacokinetics; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D045744:Cell Line, Tumor; D002986:Clinical Trials as Topic; D003474:Curcumin / Q000737:chemistry / Q000493:pharmacokinetics*; D003505:Cyclodextrins / Q000737:chemistry / Q000494:pharmacology; D004195:Disease Models, Animal; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000493:pharmacokinetics; D058185:Magnetite Nanoparticles / Q000737:chemistry; D036103:Nanotechnology; D010316:Particle Size; D011108:Polymers / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000336:Aerosols; D000970:Antineoplastic Agents; D003505:Cyclodextrins; D008081:Liposomes; D058185:Magnetite Nanoparticles; D011108:Polymers; D003474:Curcumin