title: Jesridonin in combination with paclitaxel demonstrates synergistic anti-tumor activity in human esophageal carcinoma cells.
abstract: The novel compound jesridonin, has extensive anti-tumor activity. In this study, we aim to investigate the cytotoxic effects of jesridonin in combination with paclitaxel. Our results showed that jesridonin in combination with paclitaxel had synergistic cytotoxic effects on human esophageal carcinoma both in vitro and in vivo. Hoechst 33258 staining and the Annexin-V FITC assay demonstrated that paclitaxel synergized with jesridonin in a stronger induction of apoptosis than treatment with paclitaxel or jesridonin alone. Western blotting results revealed that the synergistic apoptosis-induction effects of paclitaxel and jesridonin were mediated by the mitochondrial pathway. This may provide a novel strategy to overcome drug resistance for esophageal cancer therapy.
authors.affiliation: Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Collaborative Innovative Center of New Drug Research and Safety Evaluation, Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou University School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Collaborative Innovative Center of New Drug Research and Safety Evaluation, Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou University School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
authors.forename: Dongxiao
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Pharmacy, The Third Affiliated Hospital Of Xinxiang Medical University, 83 Hualan Avenue, Xinxiang, Henan 453003, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Collaborative Innovative Center of New Drug Research and Safety Evaluation, Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou University School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
authors.forename: Saiqi
authors.initials: S
authors.lastname: Wang
authors.affiliation: Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Collaborative Innovative Center of New Drug Research and Safety Evaluation, Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou University School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Collaborative Innovative Center of New Drug Research and Safety Evaluation, Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou University School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
authors.forename: Kairui
authors.initials: K
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Collaborative Innovative Center of New Drug Research and Safety Evaluation, Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou University School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Shi
authors.affiliation: Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Collaborative Innovative Center of New Drug Research and Safety Evaluation, Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou University School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Chang
authors.affiliation: Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Collaborative Innovative Center of New Drug Research and Safety Evaluation, Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou University School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Collaborative Innovative Center of New Drug Research and Safety Evaluation, Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou University School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ke
authors.affiliation: Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Collaborative Innovative Center of New Drug Research and Safety Evaluation, Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou University School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, Henan 450001, China. Electronic address: liuhm@zzu.edu.cn.
authors.forename: Hongmin
authors.initials: H
authors.lastname: Liu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D045786:Diterpenes, Kaurane / Q000494:pharmacology*; D004357:Drug Synergism; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004947:Esophagus / Q000187:drug effects / Q000473:pathology; D006801:Humans; D017239:Paclitaxel / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; C000606573:jesridonin; D017239:Paclitaxel
keywords: Combinatorial treatment; Cytotoxicity; Esophageal carcinoma; Jesridonin; Paclitaxel