title: Prediction of the Ebola Virus Infection Related Human Genes Using Protein-Protein Interaction Network.
abstract: BACKGROUND
  Ebola hemorrhagic fever (EHF) is caused by Ebola virus (EBOV). It is reported that human could be infected by EBOV with a high fatality rate. However, association factors between EBOV and host still tend to be ambiguous.
  
  
  OBJECTIVE
  According to the "guilt by association" (GBA) principle, proteins interacting with each other are very likely to function similarly or the same. Based on this assumption, we tried to obtain EBOV infection-related human genes in a protein-protein interaction network using Dijkstra algorithm.
  
  
  CONCLUSIONS
  We hope it could contribute to the discovery of novel effective treatments. Finally, 15 genes were selected as potential EBOV infection-related human genes.
authors.affiliation: Department of Biomedical Engineering, Tianjin Key Lab of BME Measurement, Tianjin University, Tianjin. China.
authors.forename: HuanHuan
authors.initials: H
authors.lastname: Cao
authors.affiliation: Biomedical Research Center, CODBIO Company Ltd., Tianjin. China.
authors.forename: YuHang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhao
authors.affiliation: School of Life Science, Shanghai University, Shanghai. China.
authors.forename: Liucun
authors.initials: L
authors.lastname: Zhu
authors.affiliation: School of Life Science, Shanghai University, Shanghai. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Life Science, Shanghai University, Shanghai. China.
authors.forename: JiaRui
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Biomedical Engineering, Tianjin Key Lab of BME Measurement, Tianjin University, Tianjin. China.
authors.forename: Yuan-Ming
authors.initials: YM
authors.lastname: Feng
authors.affiliation: Department of Biomedical Engineering, Tianjin Key Lab of BME Measurement, Tianjin University, Tianjin. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D030562:Databases, Protein; D029043:Ebolavirus / Q000187:drug effects; D019142:Hemorrhagic Fever, Ebola / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D060066:Protein Interaction Maps / Q000235:genetics*
keywords: Ebola virus; GO enrichment; betweenness; human protein identification; pathogenic mechanism; shortest path