title: Liver transplantation versus liver resection for hepatocellular carcinoma in intention to treat: An attempt to perform an ideal meta-analysis.
abstract: This meta-analysis compared the effects of liver transplantation (LT) and liver resection (LR) on overall survival (OS) and disease-free survival (DFS) in patients with hepatocellular carcinoma (HCC) small transplantable HCC or within Milan criteria. Articles comparing LR with LT for HCC, based on Milan criteria or small size, published up to June 2015 were selected, and a meta-analysis was performed. No randomized controlled trial has been published to date comparing survival outcomes in patients with HCC who underwent LR and LT. Nine studies were identified, including 570 patients who underwent LR and 861 who underwent LT. For HCC within the Milan criteria, the 1-year OS rates following LR and LT were 84.5% (473/560) and 84.4% (710/841), respectively (odds ratio [OR], 0.98; 95% confidence interval [CI], 0.71-1.33; P = 0.8), and the 5-year OS rates were 47.9% (273/570) and 59.3% (509/858), respectively (OR, 0.60; 95% CI, 0.35-1.02; P = 0.06). One-year DFS rates were similar (OR, 1.00; 95% CI, 0.39-2.61; P = 1.00), whereas the 3-year DFS rate was significantly lower in the LR group (54.4%, 210/386) than in the LT group (74.2%, 317/427; OR, 0.24; 95% CI, 0.07-0.80; P = 0.02), and the 5-year DFS rate was significantly lower for LR than LT (OR, 0.18; 95% CI, 0.06-0.53; P < 0.01). For small HCCs, the 5-year OS rate was significantly lower for patients who underwent LR than LT (OR, 0.30; 95% CI, 0.19-0.48; P < 0.001). In conclusion, relative to LR, LT in patients with HCC meeting the Milan criteria had no benefits before 10 years for OS. For DFS, the benefit is obtained after 3 years. Liver Transplantation 23 836-844 2017 AASLD.
authors.affiliation: Department of Digestive Surgery, University Hospital of Caen, Caen, France.|Normandie Université, UNICAEN, CEA, Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire Caen, INSERM Unités Mixtes de Recherche 1086, Centre François Baclesse, Caen, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Menahem
authors.affiliation: Department of Digestive Surgery, University Hospital of Caen, Caen, France.|Normandie Université, UNICAEN, CEA, Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire Caen, INSERM Unités Mixtes de Recherche 1086, Centre François Baclesse, Caen, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Lubrano
authors.affiliation: Department of Hepatology, University Hospital of Henri Mondor, Créteil, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Duvoux
authors.affiliation: Department of Digestive Surgery, University Hospital of Caen, Caen, France.
authors.forename: Andrea
authors.initials: A
authors.lastname: Mulliri
authors.affiliation: Department of Digestive Surgery, University Hospital of Caen, Caen, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Alves
authors.affiliation: Department of Hepatology, University Hospital of Henri Mondor, Créteil, France.
authors.forename: Charlotte
authors.identifier: 0000-0001-6115-8512
authors.initials: C
authors.lastname: Costentin
authors.affiliation: Department of Hepatology, University Hospital of Henri Mondor, Créteil, France.
authors.forename: Ariane
authors.initials: A
authors.lastname: Mallat
authors.affiliation: Normandie Université, UNICAEN, CEA, Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire Caen, INSERM Unités Mixtes de Recherche 1086, Centre François Baclesse, Caen, France.
authors.forename: Guy
authors.initials: G
authors.lastname: Launoy
authors.affiliation: Department of Hepatobiliary Surgery and Liver Transplantation, University Hospital of Henri Mondor, Créteil, France.|Unité INSERM U 1855, University Hospital of Henri Mondor, Créteil, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Laurent
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000401:mortality* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000401:mortality; D006801:Humans; D057194:Intention to Treat Analysis; D008099:Liver / Q000601:surgery; D008103:Liver Cirrhosis / Q000401:mortality / Q000601:surgery; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000401:mortality* / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D012107:Research Design; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome