title: Changes in contrast transit times on digital subtraction angiography post-Pipeline Embolization Device deployment.
abstract: It is postulated that hemodynamic changes occur in the distal vascular bed post-deployment of Pipeline Embolization Devices (PEDs). In this paper, we evaluate changes in the contrast transit times (TTs) on digital subtraction angiography (DSA) post-PED interventions. DSA films were analyzed using custom-made software for the time-density relationship at baseline and compared to post-PED deployment. All analyses were performed within the middle cerebral artery (MCA) M1 segment. Analyses included TT10%-100%(time needed for the contrast to change from 10% image intensity to 100%), TT100%-10%, and TT25%-25%. Forty-four patients were included. We found a significant decrease in TT10%-100%(2.79 to 2.24 seconds, p < 0.001) post-PED. There was a significant correlation between the percentage change in TT100%-10%and aneurysm size ( p = 0.02). There was also a significant decrease in TT25%-25%(7.07 to 6.41 seconds, p = 0.02) post-PED. Moreover, there was a significant correlation between the absolute or percentage changes in TT25%-25%and aneurysm size (rho = 0.54, p = 0.05 and rho = 0.29, p = 0.05, respectively). Statistically significant distal intracranial hemodynamic changes occur post-PED deployment. These hemodynamic changes appear to be more pronounced with large and giant aneurysms.
authors.affiliation: 1 Department of Neurosurgery, University of Illinois at Chicago, USA.
authors.forename: Ahmed E
authors.initials: AE
authors.lastname: Hussein
authors.affiliation: 1 Department of Neurosurgery, University of Illinois at Chicago, USA.|2 Department of Bioengineering, University of Illinois at Chicago, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Linninger
authors.affiliation: 1 Department of Neurosurgery, University of Illinois at Chicago, USA.
authors.forename: Sophia F
authors.initials: SF
authors.lastname: Shakur
authors.affiliation: 1 Department of Neurosurgery, University of Illinois at Chicago, USA.
authors.forename: Fady T
authors.initials: FT
authors.lastname: Charbel
authors.affiliation: 2 Department of Bioengineering, University of Illinois at Chicago, USA.
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Hsu
authors.affiliation: 1 Department of Neurosurgery, University of Illinois at Chicago, USA.
authors.forename: Fady T
authors.initials: FT
authors.lastname: Charbel
authors.affiliation: 1 Department of Neurosurgery, University of Illinois at Chicago, USA.|2 Department of Bioengineering, University of Illinois at Chicago, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Alaraj
mesh_terms: D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction; D002533:Cerebral Angiography; D003287:Contrast Media / Q000493:pharmacokinetics*; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012984:Software
chemical_list: D003287:Contrast Media
keywords: Angiography; Pipeline Embolization Device; cerebral aneurysm; contrast; flow diversion; intracranial hemodynamics; transit time