title: Assessment of plasma biomarkers for their association with Multiple Sclerosis progression.
abstract: In a cross-sectional study involving 160 Multiple Sclerosis (MS) patients and 70 healthy controls we set out to determine the association of five blood biomarkers with MS risk and progression scores. High levels of Semaphorin3A (SEMA3A) in females, and low levels of prolactin and estradiol in males associated with MS risk. High MS disability correlated with higher SEMA3A levels in females. Our findings suggest the clinical applicability of SEMA3A, and prolactin as biomarkers for MS progression. However, these biomarkers had sex-specific associations with MS, and any therapeutic approaches utilizing them should take that into consideration.
authors.affiliation: Molecular Pathology Unit, Department of Pathology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat, 13110 Jabriya, Kuwait. Electronic address: sindhujacob@hsc.edu.kw.
authors.forename: Sindhu
authors.initials: S
authors.lastname: Jacob
authors.affiliation: Department of Pathology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat, 13110 Jabriya, Kuwait. Electronic address: asmaa.alkandari@hsc.edu.kw.
authors.forename: Asmaa
authors.initials: A
authors.lastname: Al-Kandari
authors.affiliation: Division of Neurology, Department of Medicine, Amiri Hospital, Sharq, Kuwait; Neurology Clinic, Department of Medicine, Dasman Diabetes Institute, P.O. Box 1180, Dasman 15462, Kuwait. Electronic address: alroughani@gmail.com.
authors.forename: Raed
authors.initials: R
authors.lastname: Alroughani
authors.affiliation: Human Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait. Electronic address: rabeah@hsc.edu.kw.
authors.forename: Rabeah
authors.initials: R
authors.lastname: Al-Temaimi
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D006233:Persons with Disabilities; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000145:classification / Q000503:physiopathology*; D011388:Prolactin / Q000097:blood*; D040121:Semaphorin-3A / Q000097:blood*; D012727:Sex Characteristics; D013109:Sphingomyelins / Q000378:metabolism; D055815:Young Adult
chemical_list: D040121:Semaphorin-3A; D013109:Sphingomyelins; D004958:Estradiol; D011388:Prolactin
keywords: Multiple Sclerosis; Prolactin; Semaphorin3A; Sphingomyelin; Testosterone