title: Facile synthesis of chlorin bioconjugates by a series of click reactions.
abstract: A multifunctional chlorin platform appended with four short polyethylene glycols and a carboxylate-linker allows rapid conjugation to biotargeting motifs such as proteins and oligonucleotides. The stability and photophysical properties of the chlorin enable development of diagnostics, imaging, molecular tracking, and theranostics.
authors.affiliation: Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA. cdrain@hunter.cuny.edu and Chemistry Program, Graduate Center of the City University of New York, 365 5th Avenue, New York, New York 10016, USA.
authors.forename: Junior
authors.initials: J
authors.lastname: Gonzales
authors.affiliation: Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA. cdrain@hunter.cuny.edu.
authors.forename: N V S Dinesh K
authors.initials: NV
authors.lastname: Bhupathiraju
authors.affiliation: Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA. cdrain@hunter.cuny.edu.
authors.forename: William
authors.initials: W
authors.lastname: Perea
authors.affiliation: Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA. cdrain@hunter.cuny.edu and Chemistry Program, Graduate Center of the City University of New York, 365 5th Avenue, New York, New York 10016, USA.
authors.forename: Huong
authors.initials: H
authors.lastname: Chu
authors.affiliation: Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA. cdrain@hunter.cuny.edu.
authors.forename: Naxhije
authors.initials: N
authors.lastname: Berisha
authors.affiliation: Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA. cdrain@hunter.cuny.edu.
authors.forename: Veronica
authors.initials: V
authors.lastname: Bueno
authors.affiliation: Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA. cdrain@hunter.cuny.edu.
authors.forename: Naser
authors.identifier: http://orcid.org/0000-0002-2568-4643
authors.initials: N
authors.lastname: Dodic
authors.affiliation: Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA. cdrain@hunter.cuny.edu.
authors.forename: Julia
authors.initials: J
authors.lastname: Rozenberg
authors.affiliation: Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA. cdrain@hunter.cuny.edu and Chemistry Program, Graduate Center of the City University of New York, 365 5th Avenue, New York, New York 10016, USA.
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Greenbaum
authors.affiliation: Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA. cdrain@hunter.cuny.edu and Chemistry Program, Graduate Center of the City University of New York, 365 5th Avenue, New York, New York 10016, USA and Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.
authors.forename: Charles Michael
authors.initials: CM
authors.lastname: Drain
mesh_terms: D057930:Click Chemistry; D015394:Molecular Structure; D009841:Oligonucleotides / Q000737:chemistry*; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D011166:Porphyrins; D011506:Proteins; C006969:chlorin