title: Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects against H2O2-induced myocardial cell injury.
abstract: In the present study, three new triterpenoids, 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-α-L-arabinopyranoside (1), 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (2), and urs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (3), and a known triterpenoid, 3β-hydroxy-urs-2, 18-dien-28-oic acid (4, randialic acid B), were isolated from the aerial parts of Ilex cornuta. Their structures were identified by the spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR) and chemical reactions. Compound 4 showed significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury. Compounds 1-4 did not show any significant DPPH radical scavenging activity.
authors.affiliation: Children's Hospital of Soochow University, Suzhou 215003, China; College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Li
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Liu
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China. Electronic address: xuqiongming@suda.edu.cn.
authors.forename: Qiong-Ming
authors.initials: QM
authors.lastname: Xu
authors.affiliation: Children's Hospital of Soochow University, Suzhou 215003, China. Electronic address: maocm68@163.com.
authors.forename: Chen-Mei
authors.initials: CM
authors.lastname: Mao
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Yang
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000378:metabolism; D002317:Cardiovascular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000378:metabolism; D030017:Ilex / Q000737:chemistry*; D015394:Molecular Structure; D009206:Myocardium / Q000166:cytology / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000187:drug effects; D010851:Picrates / Q000378:metabolism; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D001713:Biphenyl Compounds; D002317:Cardiovascular Agents; D010851:Picrates; D010936:Plant Extracts; D014315:Triterpenes; C000616518:randialic acid B; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Aquifoliaceae; Cardiomyocytes Oxidative injury; Ilex cornuta; Triterpenoids