title: Creation of nano eye-drops and effective drug delivery to the interior of the eye.
abstract: Nano eye-drops are a new type of ophthalmic treatment with increased potency and reduced side effects. Compounds in conventional eye-drops barely penetrate into the eye because the cornea, located at the surface of eye, has a strong barrier function for preventing invasion of hydrophilic or large-sized materials from the outside. In this work, we describe the utility of nano eye-drops utilising brinzolamide, a commercially available glaucoma treatment drug, as a target compound. Fabrication of the nanoparticles of brinzolamide prodrug increases the eye penetration rate and results in high drug efficacy, compared with that of commercially available brinzolamide eye-drops formulated as micro-sized structures. In addition, the resulting nano eye-drops were not toxic to the corneal epithelium after repeated administration for 1 week. The nano eye-drops may have applications as a next-generation ophthalmic treatment.
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ikuta
authors.affiliation: Ouchi Shinko Chemical Industrial Co., Ltd., Research and Development Center, 111 Shimojyukumae, Sukagawa, Fukushima 962-0806, Japan.
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Aoyagi
authors.affiliation: Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tanaka
authors.affiliation: Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Sato
authors.affiliation: Ouchi Shinko Chemical Industrial Co., Ltd., Research and Development Center, 111 Shimojyukumae, Sukagawa, Fukushima 962-0806, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inada
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Koseki
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
authors.forename: Tsunenobu
authors.initials: T
authors.lastname: Onodera
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Oikawa
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kasai
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D019573:Epithelium, Corneal / Q000378:metabolism* / Q000473:pathology; D008297:Male; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D009883:Ophthalmic Solutions / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011355:Prodrugs / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013449:Sulfonamides / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D013843:Thiazines / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D009883:Ophthalmic Solutions; D011355:Prodrugs; D013449:Sulfonamides; D013843:Thiazines; C111827:brinzolamide