title: Separation of nuclear isomers for cancer therapeutic radionuclides based on nuclear decay after-effects.
abstract: 177Lu has sprung as a promising radionuclide for targeted therapy. The low soft tissue penetration of its β-emission results in very efficient energy deposition in small-size tumours. Because of this,177Lu is used in the treatment of neuroendocrine tumours and is also clinically approved for prostate cancer therapy. In this work, we report a separation method that achieves the challenging separation of the physically and chemically identical nuclear isomers,177mLu and177Lu. The separation method combines the nuclear after-effects of the nuclear decay, the use of a very stable chemical complex and a chromatographic separation. Based on this separation concept, a new type of radionuclide generator has been devised, in which the parent and the daughter radionuclides are the same elements. The177mLu/177Lu radionuclide generator provides a new production route for the therapeutic radionuclide177Lu and can bring significant growth in the research and development of177Lu based pharmaceuticals.
authors.affiliation: Radiation and Isotopes for Health, Department of Radiation Science and Technology, Faculty of Applied Sciences, Technical University Delft, Mekelweg 15, 2629 JB, Delft, The Netherlands.|Catalysis Engineering, Department of Chemical Engineering, Faculty of Applied Sciences, Delft University of Technology, Van der Maasweg 9, 2629 HZ, Delft, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Bhardwaj
authors.affiliation: Radiation and Isotopes for Health, Department of Radiation Science and Technology, Faculty of Applied Sciences, Technical University Delft, Mekelweg 15, 2629 JB, Delft, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: van der Meer
authors.affiliation: Radiation and Isotopes for Health, Department of Radiation Science and Technology, Faculty of Applied Sciences, Technical University Delft, Mekelweg 15, 2629 JB, Delft, The Netherlands.
authors.forename: S K
authors.initials: SK
authors.lastname: Das
authors.affiliation: Radiation and Isotopes for Health, Department of Radiation Science and Technology, Faculty of Applied Sciences, Technical University Delft, Mekelweg 15, 2629 JB, Delft, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: de Bruin
authors.affiliation: Catalysis Engineering, Department of Chemical Engineering, Faculty of Applied Sciences, Delft University of Technology, Van der Maasweg 9, 2629 HZ, Delft, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Gascon
authors.affiliation: Radiation and Isotopes for Health, Department of Radiation Science and Technology, Faculty of Applied Sciences, Technical University Delft, Mekelweg 15, 2629 JB, Delft, The Netherlands.
authors.forename: H T
authors.initials: HT
authors.lastname: Wolterbeek
authors.affiliation: Radiation and Isotopes for Health, Department of Radiation Science and Technology, Faculty of Applied Sciences, Technical University Delft, Mekelweg 15, 2629 JB, Delft, The Netherlands.
authors.forename: A G
authors.initials: AG
authors.lastname: Denkova
authors.affiliation: Radiation and Isotopes for Health, Department of Radiation Science and Technology, Faculty of Applied Sciences, Technical University Delft, Mekelweg 15, 2629 JB, Delft, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Serra-Crespo
mesh_terms: D000818:Animals; D006801:Humans; D008187:Lutetium / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000532:radiotherapy*; D011851:Radioactivity; D011868:Radioisotopes / Q000737:chemistry* / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals; D008187:Lutetium; C000615061:Lutetium-177