title: A set of interesting sequoiatones stereoisomers from a wetland soil-derived fungusTalaromyces flavus.
abstract: Four interesting sequoiatones stereoisomers (1-4) were isolated from a wetland soil-derived fungusTalaromyces flavusby chiral HPLC. On the basis of comprehensive NMR and mass analyses, their planar structures were elucidated as the same as that of sequoiatone B. Among them,1and3(or2and4) were a pair of enantiomers, and1and2(or3and4) were a pair of stereoisomers with epimerization at C-12, which indicated that sequoiatione-type metabolites exist as enantiomers rather than as optically pure compounds in some strains. With the quantum chemical ECD calculations, the absolute configurations of C-8 in1-4were determined, which is the first report to establish the absolute configuration of C-8 in sequoiatones. However, the absolute configurations of C-12 in sequoiatones are still unsolved.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Tianyu
authors.initials: T
authors.lastname: Sun
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zou
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Chen
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Xingzhong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
keywords: Electronic circular dichroism; Sequoiatone; Stereoisomers; Talaromyces flavus; Wetland soil-derived fungus