title: [Comparative Prospective Clinical Economic Study of Original and Generic Bisoprolol in Patients With Coronary Heart Disease].
abstract: OBJECTIVE
  to conduct comparative clinical and economical analysis of original and generic preparations of bisoprolol.
  
  
  METHODS
  The study included 61 patients after acute coronary syndrome (ACS) (34 men, 27 women, age 46-78 years). Patients were distributed (envelope method) to 2 groups. Patients of group A received original bisoprolol, of group C - generic drug. Duration of observation was 6 weeks. Parameters analyzed were dynamics of heart rate (HR), data of treadmill exercise test, and values of calculated cost/effectiveness ratio.
  
  
  RESULTS
  In both groups we observed significant slowing of HR. Data of treadmill test showed similar increases of volume of work.
authors.affiliation: 1Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia: 2Kirov State Medical Academy Kirov, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Tarlovskaya
authors.affiliation: 1Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia: 2Kirov State Medical Academy Kirov, Russia.
authors.forename: T I
authors.initials: TI
authors.lastname: Chudinovskih
mesh_terms: D000319:Adrenergic beta-Antagonists; D000368:Aged; D017298:Bisoprolol; D003327:Coronary Disease; D005080:Exercise Test; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000319:Adrenergic beta-Antagonists; D017298:Bisoprolol