title: Alteration of Monoamine Receptor Activity and Glucose Metabolism in Pediatric Patients with Anticonvulsant-Induced Cognitive Impairment.
abstract: A landmark study from the Institute of Medicine reported that the assessment of cognitive difficulties in children with epilepsy is timely and imperative. Anticonvulsant-induced cognitive impairment could influence the quality of life more than seizure itself in patients. Although the monoaminergic system is involved in the regulation of cognitive process, its role in anticonvulsant-induced cognitive impairment remains unclear.Methods:To explore in vivo monoamine receptor binding activity in patients with anticonvulsant-induced cognitive impairment, each patient underwent PET imaging with both monoamine receptor binding agent11C-N-methylspiperone and glucose metabolic agent18F-FDG. Tests of intelligence quotient (IQ), including verbal IQ (VIQ), performance IQ (PIQ), and full-scale IQ (FSIQ), were performed in each patient.Results:Compared with the patients with monotherapy, patients with polytherapy had significantly lower VIQ, PIQ, and FSIQ (P< 0.01 in each comparison), as well as significantly lower monoamine receptor activities detected in the caudate nucleus, prefrontal cortex, dorsal anterior cingulate cortex, and amygdale (P< 0.05 in each comparison). However, regarding the glucose metabolism, there was no significant difference found in patients with monotherapy or polytherapy (P> 0.05).Conclusion:Monoamine receptor PET imaging could be a promising in vivo imaging biomarker for mapping anticonvulsant-induced cognitive impairment.
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China.|Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China.|Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.|Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
authors.forename: Yuankai
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Paediatrics, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China; and.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China.|Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China.|Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.|Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Ji
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China.|Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China.|Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.|Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Hou
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China.|Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China.|Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.|Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China.|Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China.|Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.|Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China.|Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China.|Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.|Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China.|Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China.|Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.|Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yao
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China.|Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China.|Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.|Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
authors.forename: Peizhen
authors.initials: P
authors.lastname: Du
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China.|Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China.|Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.|Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China.|Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China.|Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.|Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Clinical Epidemiology & Biostatistics, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Zexin
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China.|Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China.|Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.|Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China meitian@zju.edu.cn.|Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China.|Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China.|Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Tian
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D060825:Cognitive Dysfunction / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D011954:Receptors, Dopamine / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*
chemical_list: D000927:Anticonvulsants; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D005947:Glucose
keywords: anticonvulsant; cognition; epilepsy; monoamine receptor; positron emission tomography (PET)