title: Mitochondrial biogenesis in neurodegeneration.
abstract: Mitochondria play a key role in energy production, calcium homeostasis, cell survival, and death. Adverse stimulations including neurodegenerative diseases may result in mitochondrial dynamic imbalance, free radical production, calcium accumulation, intrinsic cell death pathway activation and eventually cell death. Therefore, preserving or promoting mitochondrial function is a potential therapeutic target for the treatment of neurodegenerative disorders. Mitochondrial biogenesis is a process by which new mitochondria are produced from existing mitochondria. This biogenesis process is regulated by Peroxisome proliferator-activated receptor-gamma (PPARγ) coactivator-1alpha (PGC-1α). Once being activated by either phosphorylation or de-acetylation, PGC-1α activates nuclear respiratory factor 1 and 2 (NRF1 and NRF2), and subsequently mitochondrial transcription factor A (Tfam). The activation of this PGC-1α - NRF -Tfam pathway leads to synthesis of mitochondrial DNA and proteins and generation of new mitochondria. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Pharmaceutical Sciences, Biomanufacturing Research Institute Technology Enterprise (BRITE), North Carolina Central University, Durham, North Carolina.
authors.forename: P Andy
authors.identifier: 0000-0002-8712-3147
authors.initials: PA
authors.lastname: Li
authors.affiliation: Department of Pharmaceutical Sciences, Biomanufacturing Research Institute Technology Enterprise (BRITE), North Carolina Central University, Durham, North Carolina.|Department of Neurology, General Hospital of Ningxia Medical University, Ningxia Key Laboratory for Cerebrocranial Diseases, Ningxia Medical University, Yinchuan, PR China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Pharmaceutical Sciences, Biomanufacturing Research Institute Technology Enterprise (BRITE), North Carolina Central University, Durham, North Carolina.|Department of Neurosurgery, General Hospital of Ningxia Medical University, Ningxia Key Laboratory for Cerebrocranial Diseases, Ningxia Medical University, Yinchuan, PR China.
authors.forename: Shaocai
authors.initials: S
authors.lastname: Hao
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D009410:Nerve Degeneration / Q000473:pathology*; D001678:Organelle Biogenesis
keywords: mitochondrial biogenesis; mitochondrion; neurodegeneration