title: Expression of AKR1B10 as an independent marker for poor prognosis in human oral squamous cell carcinoma.
abstract: Aldo-keto reductase family 1 member B10 (AKR1B10) is implicated in xenobiotic detoxification and has disparate functions in tumorigenesis that are dependent on the cell types. The purpose of this study was to investigate the clinicopathological significance of AKR1B10 as a prognostic marker for oral squamous cell carcinomas (OSCCs).
  
  
  
  AKR1B10 protein expression was analyzed by immunohistochemistry in 77 patients with OSCC.
  
  
  
  The AKR1B10 labeling score for OSCCs (1.16 ± 1.14) was significantly higher than that for normal oral mucosa (0.10 ± 0.23; p < .0001). High expression of AKR1B10 significantly correlated with large tumor size (p = .041), advanced TNM classification (p = .037), and patient's areca quid chewing habit (p = .025). Multivariate analysis revealed that high AKR1B10 labeling score >1.16 (hazard ratio, 3.647; p = .001) significantly correlated with mortality.
  
  
  
  AKR1B10 overexpression is an independent poor prognostic biomarker for OSCC. AKR1B10 inhibitors may be promising in clinical trials against OSCC. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1327-1332, 2017.
authors.affiliation: Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.|Department of Dentistry, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan.
authors.forename: Hui-Hsin
authors.initials: HH
authors.lastname: Ko
authors.affiliation: Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan.|Department of Chemical Engineering and Materials Science, Yuan-Ze University, Chung-Li, Taiwan.
authors.forename: Shih-Lung
authors.identifier: 0000-0003-4674-4892
authors.initials: SL
authors.lastname: Cheng
authors.affiliation: School of Dentistry, National Taiwan University, Taipei, Taiwan.|Department of Dentistry, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan.
authors.forename: Jang-Jaer
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.|School of Dentistry, National Taiwan University, Taipei, Taiwan.|Department of Dentistry, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan.|Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
authors.forename: Hsin-Ming
authors.initials: HM
authors.lastname: Chen
authors.affiliation: Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.|School of Dentistry, National Taiwan University, Taipei, Taiwan.|Department of Dentistry, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan.
authors.forename: Mark Yen-Ping
authors.initials: MY
authors.lastname: Kuo
authors.affiliation: Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.|School of Dentistry, National Taiwan University, Taipei, Taiwan.|Department of Dentistry, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan.
authors.forename: Shih-Jung
authors.initials: SJ
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D000449:Aldehyde Reductase / Q000235:genetics*; D000074408:Aldo-Keto Reductases; D014408:Biomarkers, Tumor / Q000235:genetics; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D015331:Cohort Studies; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D013624:Taiwan
chemical_list: D014408:Biomarkers, Tumor; C120471:AKR1B10 protein, human; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase
keywords: AKR1B10; areca quid; oral cancer; prognosis