title: [Thromboxane A2: Mechanisms of Synthesis and Intracellular Signaling System of Realization].
abstract: One of major complications of ischemic heart disease is myocardial infarction, which develops as a result of thrombosis at the site of ruptured atherosclerotic plaque. Platelets activation and aggregation are the key events of this process. The efficiency of aspirin and/or clopidogrel use is limited by residual platelet reactivity what indicates the need to explore its mechanisms. This review covers intracellular signaling systems involved in realization of effects of the main platelet agonists in order to specify new molecules for the target therapy in case of aspirin resistance.
authors.affiliation: Donetsk National Medical University named after M. Gorky, Donetsk, Ukraine.
authors.forename: E F
authors.initials: EF
authors.lastname: Barinov
mesh_terms: D006801:Humans; D009203:Myocardial Infarction / Q000378:metabolism; D017202:Myocardial Ischemia / Q000378:metabolism; D058226:Plaque, Atherosclerotic; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism; D015398:Signal Transduction; D013928:Thromboxane A2 / Q000378:metabolism*
chemical_list: D010975:Platelet Aggregation Inhibitors; D013928:Thromboxane A2