title: With the Help of MOM: Mitochondrial Contributions to Cellular Quality Control.
abstract: Mitochondria are essential organelles because they have key roles in cellular energy metabolism and many other metabolic pathways. Several quality control systems have evolved to ensure that dysfunctional mitochondria are either repaired or eliminated. The activities of these pathways are crucial for cellular health because they maintain functional mitochondria. In addition, the cytosolic ubiquitin-proteasome system (UPS) and the mitochondria-associated degradation pathway (MAD) share some of their core components, are functionally tightly interconnected, and mutually modulate their activities. Thus, the mitochondrial outer membrane (MOM) actively supports quality control systems in extramitochondrial compartments. Furthermore, mitochondrial quality surveillance systems also act on cytosolic or endoplasmic reticulum (ER) substrates and modulate immune responses. Therefore, mitochondria contribute to cellular quality control and homeostasis on several levels.
authors.affiliation: Institut für Zellbiologie, Universität Bayreuth, Universitätsstraße 30, 95440 Bayreuth, Germany. Electronic address: ralf.braun@uni-bayreuth.de.
authors.forename: Ralf J
authors.initials: RJ
authors.lastname: Braun
authors.affiliation: Institut für Zellbiologie, Universität Bayreuth, Universitätsstraße 30, 95440 Bayreuth, Germany. Electronic address: benedikt.westermann@uni-bayreuth.de.
authors.forename: Benedikt
authors.initials: B
authors.lastname: Westermann
mesh_terms: D000818:Animals; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D007109:Immunity; D008928:Mitochondria / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism*; D063306:Mitophagy; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species