title: Genetic analysis ofHairy-wing mutations.
abstract: We studied the genetic bases of threeHairy-wing (Hw1,HwUa,Hw49c) mutations mapping in the region of theachaete-scute complex (AS-C). Analysis of X-ray-induced revertants ofHw1andHw49cuncoveredachaete andscute mutant phenotypes respectively. This indicates that theHw mutant phenotypes result from an excess of function of these genes of theachaete-scute complex (AS-C). The phenotypes of the differentHws show allelic specificity in the pattern of extrachaetes. In addition to these mutations, certain inversions and internal duplications of the AS-C also produce aHw-variegated phenotype, probably due to variegation or decompensation of the genes of the AS-C. The expressivity of the differentHws (mutation or variegation) is modulated by the number of doses of the AS-C present in the genome. A similar dose-dependent modulation is exerted by the transregulatory geneshairy andextramacrochaetae. We discuss these results on the basis of a regulation model of the expression of the AS-C.
authors.affiliation: Instituto de Biología Molecular, C.S.I.C., Facultad de Ciencias, Universidad Autónoma de Madrid, Canto Blanco, 28049, Madrid, Spain.
authors.forename: L García
authors.initials: LG
authors.lastname: Alonso
authors.affiliation: Instituto de Biología Molecular, C.S.I.C., Facultad de Ciencias, Universidad Autónoma de Madrid, Canto Blanco, 28049, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: García-Bellido
keywords: Cell differentiation; Gene organization; Gene regulation; Pattern formation