title: Human Cases of Fascioliasis in Fujian Province, China.
abstract: Fascioliasis is a foodborne zoonotic parasitic disease. We report 4 cases occurring in the same family, in whom diagnosis of acute fascioliasis was established after series of tests. One case was hospitalized with fever, eosinophilia, and hepatic lesions. MRI showed hypodense changes in both liver lobes. The remaining 3 cases presented with the symptom of stomachache only. Stool analysis was positive forFasciolaeggs in 2 adult patients. The immunological test and molecular identification of eggs were confirmed at the National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China. The results of serological detection were positive in all the 4 patients. DNA sequencing of PCR products of the eggs demonstrated 100% homology with ITS andcox1ofFasciola hepatica. The conditions of the patients were not improved by broad-spectrum anti-parasitic drugs until administration of triclabendazole.
authors.affiliation: National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health and Family Planning Commission, Shanghai 200025, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ai
authors.affiliation: National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health and Family Planning Commission, Shanghai 200025, China.
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Cai
authors.affiliation: National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health and Family Planning Commission, Shanghai 200025, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health and Family Planning Commission, Shanghai 200025, China.
authors.forename: Jia-Xu
authors.initials: JX
authors.lastname: Chen
authors.affiliation: National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health and Family Planning Commission, Shanghai 200025, China.
authors.forename: Shao-Hong
authors.initials: SH
authors.lastname: Chen
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000032:analysis; D002681:China; D018509:DNA, Helminth / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D003576:Electron Transport Complex IV / Q000235:genetics; D005210:Fasciola hepatica / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D005211:Fascioliasis / Q000175:diagnosis* / Q000469:parasitology / Q000473:pathology*; D005243:Feces / Q000469:parasitology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008853:Microscopy; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D000947:Antigens, Helminth; D018509:DNA, Helminth; D021903:DNA, Ribosomal Spacer; D003576:Electron Transport Complex IV
keywords: Fasciola hepatica; diagnosis; human case; triclabendazole