title: Asymmetric Hydrogenation of In Situ Generated Isochromenylium Intermediates by Copper/Ruthenium Tandem Catalysis.
abstract: The first asymmetric hydrogenation of in situ generated isochromenylium derivatives is enabled by tandem catalysis with a binary system consisting of Cu(OTf)2and a chiral cationic ruthenium-diamine complex. A range of chiral 1H-isochromenes were obtained in high yields with good to excellent enantioselectivity. These chiral 1H-isochromenes could be easily transformed into isochromanes, which represent an important structural motif in natural products and biologically active compounds. The chiral induction was rationalized by density functional theory calculations.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, 100190, P.R. China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P.R. China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Miao
authors.affiliation: BNLMS, Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing, 100871, P.R. China.
authors.forename: Zi-You
authors.initials: ZY
authors.lastname: Tian
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, 100190, P.R. China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P.R. China.
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: He
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, 100190, P.R. China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, 100190, P.R. China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P.R. China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Chen
authors.affiliation: BNLMS, Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing, 100871, P.R. China.
authors.forename: Zhi-Xiang
authors.initials: ZX
authors.lastname: Yu
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, 100190, P.R. China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P.R. China.
authors.forename: Qing-Hua
authors.identifier: 0000-0001-9675-2239
authors.initials: QH
authors.lastname: Fan
keywords: asymmetric catalysis; heterocycles; hydrogenation; ruthenium; tandem reactions