title: Relationship between intraocular pressure, anterior chamber depth and lens thickness in primary open-angle glaucoma patients.
abstract: BACKGROUND
  To investigate the relationship between intraocular pressure (IOP), anterior chamber depth (ACD) and lens thickness (LT) in primary open-angle glaucoma (POAG) patients and compare with age- and sex-matched controls.
  
  
  METHODS
  A cross-sectional analytical study of 62 newly diagnosed POAG patients compared with 62 age- and sex-matched control subjects in a tertiary eye clinic. Socio-demographic data and ocular examinations were documented. IOP was measured using the Goldmann applanation tonometer. LT and ACD were measured using A-scan ultrasonography and the IOLMaster, respectively. Data were analyzed using SPSS version 19.0 and level of significance set at p value <0.05.
  
  
  RESULTS
  In the glaucoma group and control groups, respectively, mean age was 60.3 ± 8.9 and 58.5 ± 8.1 years (p = 0.234), mean IOP was 28.27 ± 7.88 and 14.47 ± 2.60 mmHg (p < 0.001), mean ACD was 3.12 ± 0.27 and 3.15 ± 0.24 mm (p = 0.514), mean LT was 4.24 ± 0.46 and 4.23 ± 0.45 mm (p = 0.903), and mean ACD was shallower in females (p = 0.034) and (p = 0.001). In the glaucoma group, there was a positive correlation between IOP and ACD (r = 0.022, p = 0.864), but a negative correlation between IOP and LT (r = -0.04, p = 0.758) and ACD and LT (r = -0.058, p = 0.657). In the control group, there was a positive correlation between IOP and ACD (r = 0.141, p = 0.275), IOP and LT (r = 0.031, p = 0.811) and ACD and LT (r = 0.016, p = 0.901).
  
  
  CONCLUSIONS
  ACD is shallower in females. There is no significant correlation between IOP and ACD or between IOP and LT in POAG as well as normal individuals.
authors.affiliation: Ophthalmology Department, College of Heath Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria. dr.bolajoko@yahoo.com.
authors.forename: Bolajoko A
authors.initials: BA
authors.lastname: Adewara
authors.affiliation: Ophthalmology Department, College of Heath Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
authors.forename: Bernice O
authors.initials: BO
authors.lastname: Adegbehingbe
authors.affiliation: Ophthalmology Department, College of Heath Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
authors.forename: Oluwatoyin H
authors.initials: OH
authors.lastname: Onakpoya
authors.affiliation: Ophthalmology Department, Lily Hospitals Limited, Warri, Nigeria.
authors.forename: Chidi G
authors.initials: CG
authors.lastname: Ihemedu
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000867:Anterior Chamber / Q000473:pathology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D007908:Lens, Crystalline / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014065:Tonometry, Ocular
keywords: Anterior chamber depth; Intraocular pressure; Lens thickness; Nigeria; Primary open-angle glaucoma