title: Association between Free Triiodothyronine Levels and Peripheral Arterial Disease in Euthyroid Participants.
abstract: This current cross-sectional study investigates the relationship between thyroid hormones and peripheral artery disease (PAD) among euthyroid Chinese population aged 40 years and above. Serum free triiodothyronine (FT3), free thyroxin (FT4), thyroid-stimulating hormone (TSH), and thyroid antibodies were measured. PAD was defined as ankle-brachial index (ABI) < 0.9. There were 91 (2.9%) PAD cases among the 3,148 euthyroid study participants. Participants in the highest quartile of FT3 and free-triiodothyronine-to-free-thyroxin (FT3/FT4 ratio) had a decreased risk of prevalent PAD (multivariate-adjusted odds ratio, 95% confidence interval: 0.32, 0.15-0.62, P for trend = 0.01 and 0.31, 0.13-0.66, P for trend = 0.004, respectively) compared to those in the lowest quartile. To conclude, FT3 levels and the FT3/FT4 ratio was inversely associated with prevalent PAD in euthyroid Chinese population aged 40 years and above.
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
authors.forename: Po
authors.initials: P
authors.lastname: Wang
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
authors.forename: Rui
authors.initials: R
authors.lastname: DU
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ding
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
authors.forename: Kui
authors.initials: K
authors.lastname: Peng
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
authors.forename: Yu Fang
authors.initials: YF
authors.lastname: Bi
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
authors.forename: Wei Qing
authors.initials: WQ
authors.lastname: Wang
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
authors.forename: Jie Li
authors.initials: JL
authors.lastname: Lu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000097:blood*; D012307:Risk Factors; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D014284:Triiodothyronine; D013974:Thyroxine