title: [Interaction Between Personality, Pain, and Genes in Ischemic Heart Disease].
abstract: Personality traits of the patient with ischemic heart disease (IHD) are thought to determine disease course. Their level depends on clinical presentations of IHD including the presence of cardiac pain. The aim of the study was to identify the modifying effect of genes coding for serotonin transporter (5-HTTLPR), serotonin receptor type 2A (A-1438G) and 2C (Cys23Ser) as well as brain-derived neurotrophic factor (Val66Met) on personality traits in pain and painless forms of IHD. We found interaction between pain and personality factors mediated by genetic variant. Pain syndrome was associated with higher neuroticism scores in carriers of allele S (5-HTTLPR), allele Ser (5-HTR2C), and the genotype ValVal (BDNF) and with higher hostility levels in patients with allele Ser. The results may be used for purposes of personalized examination of IHD patients directed to prevention of unfavorable course of the disease.
authors.affiliation: Mental Health Research Center, Moscow, Russia.|Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Golimbet
authors.affiliation: Mental Health Research Center, Moscow, Russia.|Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: B A
authors.initials: BA
authors.lastname: Volel
authors.affiliation: Mental Health Research Center, Moscow, Russia.|Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: S N
authors.initials: SN
authors.lastname: Enikopolov
authors.affiliation: Mental Health Research Center, Moscow, Russia.|Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: G I
authors.initials: GI
authors.lastname: Korovaytseva
authors.affiliation: Mental Health Research Center, Moscow, Russia.|Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: F Yu
authors.initials: FY
authors.lastname: Kopulov
mesh_terms: D000367:Age Factors; D000368:Aged; D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D010146:Pain / Q000235:genetics / Q000503:physiopathology; D010551:Personality / Q000235:genetics; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D050486:Serotonin Plasma Membrane Transport Proteins; C579455:BDNF protein, human
keywords: aggression; gene polymorphism; ischemic heart disease; neuroticism; pain; serotonin