title: Autogenous Bone Marrow Aspirate Coated Synthetic Hydroxyapatite for Reconstruction of Maxillo-Mandibular Osseous Defects: A Prospective Study.
abstract: OBJECTIVE
  This prospective study was conducted to evaluate the bone regeneration capacity of synthetic hydroxyapatite mixed with autogenous bone marrow aspirate when used as a bone graft substitute in maxillo-mandibular osseous defects.
  
  
  METHODS
  This study included nine patients with histopathalogically proven benign osteolytic lesions in maxilla and mandible that were treated with enucleation or marginal resection followed by bone marrow aspirate coated synthetic biphasic hydroxyapatite (hydroxyapatite and beta tricalcium phosphate) graft placement. Incorporation of graft was assessed based on Irwin's radiologic staging. The efficacy of graft to form new bone was radiologically evaluated by observing the sequential changes of density at grafted site using gray scale level histogram which was processed in adobe photoshop 7.0 elements. Clinical assessment of recipient and donor sites was done.
  
  
  RESULTS
  Based on Irwin's radiologic staging, at 6 month follow up period, obvious incorporation of graft with new bone was observed. Sequential changes in bone density measured by gray scale histogram revealed initial resorption followed by replacement of BMA coated hydroxyapatite with new bone formation. None of the patients eventually had complications like infection, wound dehiscence, graft loss at recipient sites at 6 months follow up period.
  
  
  CONCLUSIONS
  Autogenous bone marrow aspirate in combination with synthetic hydroxyapatite is an effective option for accelerating bone regeneration in small to moderate sized jaw bone defects. This mixture provides all the three critical elements needed for bone regeneration (osteogenesis, osteoinduction and osteoconduction) with an added advantage of obviating donor site morbidity.
authors.affiliation: Deprtment of Oral and Maxillofacial Surgery, Narayana Dental College & Hospital, Nellore, Andhra Pradesh 524003 India.
authors.forename: Raja Sekhar
authors.initials: RS
authors.lastname: Gali
authors.affiliation: Deprtment of Oral and Maxillofacial Surgery, Narayana Dental College & Hospital, Nellore, Andhra Pradesh 524003 India.
authors.forename: Sathya Kumar
authors.initials: SK
authors.lastname: Devireddy
authors.affiliation: Department of Pathology, Narayana Dental College & Hospital, Nellore, Andhra Pradesh 524003 India.
authors.forename: N
authors.initials: N
authors.lastname: Mohan Rao
authors.affiliation: Deprtment of Oral and Maxillofacial Surgery, Narayana Dental College & Hospital, Nellore, Andhra Pradesh 524003 India.
authors.forename: R V
authors.initials: RV
authors.lastname: Kishore Kumar
authors.affiliation: Deprtment of Oral and Maxillofacial Surgery, Narayana Dental College & Hospital, Nellore, Andhra Pradesh 524003 India.
authors.forename: Sridhar Reddy
authors.initials: SR
authors.lastname: Kanubaddy
authors.affiliation: Deprtment of Oral and Maxillofacial Surgery, Narayana Dental College & Hospital, Nellore, Andhra Pradesh 524003 India.
authors.forename: Mallikarjuna
authors.initials: M
authors.lastname: Dasari
authors.affiliation: Deprtment of Oral and Maxillofacial Surgery, Narayana Dental College & Hospital, Nellore, Andhra Pradesh 524003 India.
authors.forename: K
authors.initials: K
authors.lastname: Sowjanya
authors.affiliation: Department of Clinical Pharmacology, Narayana Dental College & Hospital, Nellore, Andhra Pradesh 524003 India.
authors.forename: Rama Mohan
authors.initials: RM
authors.lastname: Pathapati
keywords: Benign bone tumor; Bone graft substitute; Bone marrow aspirate; Calcium phosphate ceramic; Hydroxyapatite; Mandible