title: Helicobacter pylori Outer Membrane Protein-Related Pathogenesis.
abstract: Helicobacter pyloricolonizes the human stomach and induces inflammation, and in some cases persistent infection can result in gastric cancer. Attachment to the gastric mucosa is the first step in establishing bacterial colonization, and outer membrane proteins (OMPs) play a pivotal role in binding to human cells. Some OMP interaction molecules are known inH. pylori, and their associated host cell responses have been gradually clarified. Many studies have demonstrated that OMPs are essential to CagA translocation into gastric cells via the Type IV secretion system ofH. pylori. This review summarizes the mechanisms through whichH. pyloriutilizes OMPs to colonize the human stomach and how OMPs cooperate with the Type IV secretion system.
authors.affiliation: Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-Machi, Yufu-City, Oita 879-5593, Japan. m13d9013@oita-u.ac.jp.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Matsuo
authors.affiliation: Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-Machi, Yufu-City, Oita 879-5593, Japan. kidoyasu@oita-u.ac.jp.
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Kido
authors.affiliation: Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-Machi, Yufu-City, Oita 879-5593, Japan. yyamaokal@oita-u.ac.jp.|Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA. yyamaokal@oita-u.ac.jp.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamaoka
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism; D016480:Helicobacter pylori / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D001425:Bacterial Outer Membrane Proteins; D037521:Virulence Factors
keywords: Helicobacter pylori; Type IV secretion system; outer membrane protein; pathogenesis