title: Inhibition of indoleamine 2,3-dioxygenase 1/2 prevented cognitive impairment and energetic metabolism changes in the hippocampus of adult rats subjected to polymicrobial sepsis.
abstract: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection that may affect the brain. We investigated the role of indoleamine 2,3-dioxygenase (IDO-1/2) inhibition on long-term memory and energetic metabolism after experimental sepsis by caecal ligation and perforation (CLP). Experimental sepsis increased the activity of complexes I, II-III and IV at 24h after CLP, and IDO-1/2 inhibition normalized the activity of these complexes in the hippocampus. Wistar rats presented impairment of habituation and aversive memories 10days after CLP. Adjuvant treatment with the IDO inhibitor prevented long-term cognitive impairment triggered by sepsis.
authors.affiliation: Research Group of Experimental Neuropathology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil. Electronic address: clarissamc@gmail.com.
authors.forename: Clarissa M
authors.initials: CM
authors.lastname: Comim
authors.affiliation: Research Group of Experimental Neuropathology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil.
authors.forename: Viviane
authors.initials: V
authors.lastname: Freiberger
authors.affiliation: Research Group of Experimental Neuropathology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil.
authors.forename: Letícia
authors.initials: L
authors.lastname: Ventura
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
authors.forename: Francielle
authors.initials: F
authors.lastname: Mina
authors.affiliation: Laboratory of Bioenergetics, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil.
authors.forename: Gabriela K
authors.initials: GK
authors.lastname: Ferreira
authors.affiliation: Laboratory of Experimental Physiopathology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors.forename: Monique
authors.initials: M
authors.lastname: Michels
authors.affiliation: Laboratory of Experimental Physiopathology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors.forename: Jaqueline S
authors.initials: JS
authors.lastname: Generoso
authors.affiliation: Laboratory of Bioenergetics, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil.
authors.forename: Emílio L
authors.initials: EL
authors.lastname: Streck
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil; Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Neuroscience Graduate Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA.
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
authors.affiliation: Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil; Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Barichello
authors.affiliation: Laboratory of Experimental Physiopathology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism* / Q000517:prevention & control*; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D005106:Exploratory Behavior / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D006649:Histocompatibility Antigens / Q000378:metabolism; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism*; D007266:Inhibition, Psychological; D007270:Injections, Intra-Articular; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000150:complications* / Q000209:etiology / Q000382:microbiology; D018709:Statistics, Nonparametric; D013566:Sympathomimetics / Q000494:pharmacology / Q000627:therapeutic use; D010136:p-Hydroxyamphetamine / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D006649:Histocompatibility Antigens; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D013566:Sympathomimetics; D010136:p-Hydroxyamphetamine
keywords: Cognitive impairment; Energetic metabolism; Indoleamine 2,3-dioxygenase 1/2; Sepsis