title: Necessity of carbapenem use when prescribed per infectious diseases specialists.
abstract: Preauthorization strategies, including restricting broad-spectrum antimicrobials such as carbapenems to infectious diseases physicians (ID) are commonly employed by stewardship programs. The appropriateness, or "necessity" of empiric carbapenem therapy by ID, defined as an isolated organism sensitive to the carbapenem and resistant to cefepime, was evaluated over a 6month span and included 84 patients. Additionally, 30 patients followed by ID who were not prescribed a carbapenem until final susceptibilities were included as a definitive therapy group. Differences in multi-drug resistant organism (MDRO) risk factors between groups were non-significant. Carbapenem therapy was necessary for only 6 (7%) empiric therapy patients, while four times as many definitive group patients required a carbapenem but did not receive one empirically. Overall, ID's ability to accurately gauge which patients required carbapenems appeared poor in this study. Alternative risk stratification strategies may better guide broad-spectrum antimicrobial use than ID judgment alone.
authors.affiliation: Department of Pharmacy, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA. Electronic address: kellie.goodlet@hhchealth.org.
authors.forename: Kellie J
authors.initials: KJ
authors.lastname: Goodlet
authors.affiliation: Department of Pharmacy, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA; University of Connecticut School of Pharmacy, 69 North Eagleville Road, Unit 3092, Storrs, CT 06269, USA. Electronic address: michael.nailor@hhchealth.org.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Nailor
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015780:Carbapenems / Q000627:therapeutic use*; D003141:Communicable Diseases / Q000188:drug therapy*; D011307:Drug Prescriptions / Q000592:standards; D004363:Drug Utilization / Q000592:standards*; D005260:Female; D006302:Health Services Research; D006801:Humans; D055552:Infectious Disease Medicine; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013038:Specialization; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems
keywords: Antimicrobial; Preauthorization; Resistance; Restriction; Stewardship