title: Locally Recurrent Lentigo Maligna and Lentigo Maligna Melanoma: Characteristics and Time to Recurrence After Surgery.
abstract: BACKGROUND
  Various studies have reported local recurrence (LR) rates after surgical treatment of lentigo maligna (LM) and lentigo maligna melanoma (LMM). However, the time to LR of LM/LMM is not currently known, as few studies report time to LR and have long-term follow-up.
  
  
  OBJECTIVE
  To define time to LR in LM/LMM after surgical treatment, and to describe features of observed LR.
  
  
  METHODS
  Retrospective single-center study of consecutive patients presenting with locally recurrent LM/LMM.
  
  
  RESULTS
  Six hundred forty-nine cases of LM/LMM were reviewed; 29 (21 LM, and 8 LMM) of 41 locally recurrent cases had original histology reports and were included. The mean time to LR was 57.5 months (range 7-194). For cases presenting as primary LM, LR was also in situ in 14/21 (67%) of cases. Seven of 21 LM recurred as LMM. Of the 8 primary LMM, 3/8 (37.5%) presented with subsequent LMM and all were slightly deeper on re-excision.
  
  
  CONCLUSIONS
  The mean time to LR of LM/LMM is at least 57.5 months, underscoring the importance of long-term follow-up. Seven of 21 LM recurred as invasive disease, but the lack of development of LMM from LM in most recurrent cases confirms LM is slowly progressive.
authors.affiliation: *Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York; †Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Connolly
authors.forename: Brian P
authors.initials: BP
authors.lastname: Hibler
authors.forename: Erica H
authors.initials: EH
authors.lastname: Lee
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Rossi
authors.forename: Klaus J
authors.initials: KJ
authors.lastname: Busam
authors.forename: Kishwer S
authors.initials: KS
authors.lastname: Nehal
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery*; D013997:Time Factors