title: Trends in spoligotype patterns ofMycobacterium tuberculosisstrains in central India.
abstract: This study aims to understand trends in spoligotype patterns of Mycobacterium tuberculosis (MTB) in Central India. Elucidation of these trends may provide baseline information to understand the transmission dynamics of strains of MTB in the region. Spoligotyping was carried out on 340 MTB strains isolated from clinical samples received from 2007 to 2011. The prevalence of ST26/CAS1_Del, ST11/EAI3_IND, ST288/CAS2, ST25/CAS1_Del and Beijing lineages showed waxing and waning trends. ST26/CAS1_Del and ST11/EAI3_IND lineages were consistently present and were predominant. Well-established lineages showed a consistent presence in the community. New orphan lineages appeared to be less capable of establishing themselves.
authors.affiliation: Department of Microbiology, NRL, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.
authors.forename: Prabha
authors.initials: P
authors.lastname: Desikan
authors.affiliation: National JALMA Institute of Leprosy and Other Mycobacterial Diseases, Indian Council of Medical Research, Dr. Miyazaki Marg, Agra, Uttar Pradesh, India.
authors.forename: Devendra S
authors.initials: DS
authors.lastname: Chauhan
authors.affiliation: Department of Microbiology, NRL, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.
authors.forename: Nikita
authors.initials: N
authors.lastname: Panwalkar
authors.affiliation: National JALMA Institute of Leprosy and Other Mycobacterial Diseases, Indian Council of Medical Research, Dr. Miyazaki Marg, Agra, Uttar Pradesh, India.
authors.forename: Pragya
authors.initials: P
authors.lastname: Sharma
authors.affiliation: National JALMA Institute of Leprosy and Other Mycobacterial Diseases, Indian Council of Medical Research, Dr. Miyazaki Marg, Agra, Uttar Pradesh, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Yadav
mesh_terms: D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D017720:Molecular Epidemiology; D058889:Molecular Typing; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D015995:Prevalence; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology*