title: Invasive Ductal Carcinoma: Correlation of Immunophenotypic Features with Age.
abstract: OBJECTIVE
  To evaluate the frequency of hormone receptors and Her2neu expression and their correlation with age in patients of carcinoma breast.
  
  
  METHODS
  Descriptive, cross-sectional study.
  
  
  METHODS
  Department of Histopathology, Dr. Ziauddin Hospital, Karachi, between the period 2006 - 2013.
  
  
  METHODS
  Estrogen receptors, progesterone receptors and Her2neu immunohistochemical staining was performed on all specimens of carcinoma breast of female patients. Allred scoring was followed using normal epithelium as internal control. Age was determined in years. Results were described as percentages.
  
  
  RESULTS
  Three hundred and forty-six cases of infiltrating ductal carcinoma of breast between the age of 20 - 90 years (mean= 49 ±14 years) were studied. Seventy-nine (23%) cases were below the age of 40 years. ER +ve cases were 210 (61%), PR +ve were 190 (55%), and 78 (23%) were Her2neu +ve. Three were 12 (3%) triple positive cases and 58 (17%) triple negative cases. One hundred and seven (31%) cases were ER/PR+ve and Her2neu -ve. Most of the breast cancer cases were aged between 41 - 50 years. Estrogen receptor positivity was maximum between 41 - 60 years. Fifty percent cases of carcinoma breast below 30-year age were also ER positive.
  
  
  CONCLUSIONS
  A high proportion of breast cancer in young Pakistani females is alarming. Younger age harbours aggressive clinicopathologic characteristics. There is a due need for identifying high risk individuals/families including BRCA1 and BRCA2 testings, biologically driven trials devoted specifically to this group.
authors.affiliation: Department of Histopathology, Dr. Ziauddin University Hospital, Karachi.
authors.forename: Fouzia
authors.initials: F
authors.lastname: Lateef
authors.affiliation: Department of Histopathology, Dr. Ziauddin University Hospital, Karachi.
authors.forename: Saba
authors.initials: S
authors.lastname: Jamal
authors.affiliation: Department of Histopathology, Dr. Ziauddin University Hospital, Karachi.
authors.forename: Surrayya
authors.initials: S
authors.lastname: Nasir
authors.affiliation: Department of Histopathology, Dr. Ziauddin University Hospital, Karachi.
authors.forename: Zainab
authors.initials: Z
authors.lastname: Jamil
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D008408:Mastectomy / Q000379:methods; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D018570:Risk Assessment; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human