title: Risk factors and clinical outcome of profound thrombocytopenia in adult patients with DENV infections.
abstract: Severe thrombocytopenia is common in dengue virus (DENV) infections. However, studies focusing on the role of profound thrombocytopenia (PT) (nadir platelet counts ≤ 20 000/mm3) in DENV infections are scarce. This study aims to identify the associated features and outcome of DENV patients with PT. It involves 237 adult hospitalized patients who were DENV PCR positive. The presence of comorbidity (AOR = 4.625; 95% CI = 1.113-19.230), higher admission hematocrit (AOR = 1.213; 95% CI = 1.067-1.379), lower admission albumin (AOR = 0.870; 95% CI = 0.766-0.988) and lower admission platelets (AOR = 0.980; 95% CI = 0.969-0.991) was associated with platelets ≤ 20 000/mm3in multivariate logistic regression. PT was not affected by DENV serotypes, coinfections and secondary DENV infections. Patients with PT had significantly higher risk of experiencing warning signs (AOR = 3.709, 95% CI = 1.089-12.634) and longer hospital stay (AOR = 1.943, 95% CI = 1.010-3.774). However, severe dengue disease, hemorrhagic manifestations and need for intensive care were not significantly associated with PT.
authors.affiliation: a Jeffrey Cheah School of Medicine and Health Sciences , Monash University Malaysia , Bandar Sunway , Selangor , Malaysia.
authors.forename: Amreeta
authors.initials: A
authors.lastname: Dhanoa
authors.affiliation: b Department of Pathology , Hospital Sultanah Aminah Johor Bahru , Johor , Malaysia.
authors.forename: Ganeswrie
authors.initials: G
authors.lastname: Rajasekaram
authors.affiliation: a Jeffrey Cheah School of Medicine and Health Sciences , Monash University Malaysia , Bandar Sunway , Selangor , Malaysia.
authors.forename: Sharifah Syed
authors.initials: SS
authors.lastname: Hassan
authors.affiliation: a Jeffrey Cheah School of Medicine and Health Sciences , Monash University Malaysia , Bandar Sunway , Selangor , Malaysia.
authors.forename: Amutha
authors.initials: A
authors.lastname: Ramadas
authors.affiliation: a Jeffrey Cheah School of Medicine and Health Sciences , Monash University Malaysia , Bandar Sunway , Selangor , Malaysia.
authors.forename: Nur Amelia
authors.initials: NA
authors.lastname: Azreen Adnan
authors.affiliation: c Clinical School Johor Bahru, Jeffrey Cheah School of Medicine and Health Sciences , Monash University Malaysia , Johor , Malaysia.
authors.forename: Chun Fatt
authors.initials: CF
authors.lastname: Lau
authors.affiliation: c Clinical School Johor Bahru, Jeffrey Cheah School of Medicine and Health Sciences , Monash University Malaysia , Johor , Malaysia.
authors.forename: Teik Seng
authors.initials: TS
authors.lastname: Chan
authors.affiliation: c Clinical School Johor Bahru, Jeffrey Cheah School of Medicine and Health Sciences , Monash University Malaysia , Johor , Malaysia.
authors.forename: Chin Fang
authors.initials: CF
authors.lastname: Ngim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology*; D003716:Dengue Virus / Q000472:pathogenicity / Q000502:physiology; D005260:Female; D006400:Hematocrit; D006470:Hemorrhage / Q000097:blood* / Q000473:pathology; D006760:Hospitalization; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012189:Retrospective Studies; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism; D019595:Severe Dengue / Q000097:blood* / Q000150:complications / Q000473:pathology; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000097:blood* / Q000150:complications / Q000473:pathology
chemical_list: D012709:Serum Albumin
keywords: DENV infections; Dengue; thrombocytopenia