title: Total Synthesis of (±)-Grandilodine B.
abstract: The first total synthesis of the opened-type Kopsia alkaloid grandilodine B is reported. Four stereocenters of this alkaloid, three of them quaternary, are stereoselectively generated by a Diels-Alder reaction, a diastereoselective cyanation of tertiary alcohol, and a facial-selective nitrone 1,3-dipolar cycloaddition.
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
authors.forename: Zhonglei
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
authors.forename: Xiaoni
authors.initials: X
authors.lastname: Xie
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Yao
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
authors.forename: Liansuo
authors.identifier: 0000-0001-7747-2979
authors.initials: L
authors.lastname: Zu