title: Targeted Drugs as Maintenance Therapy after Autologous Stem Cell Transplantation in Patients with Mantle Cell Lymphoma.
abstract: The treatment landscape for mantle cell lymphoma (MCL) is rapidly evolving toward the incorporation of novel and biologically targeted pharmaceuticals with improved disease activity and gentler toxicity profiles compared with conventional chemotherapeutics. Upfront intensive treatment of MCL includes autologous stem cell transplantation (SCT) consolidation aimed at deepening and lengthening disease remission, but subsequent relapse occurs. Maintenance therapy after autologous SCT in patients with MCL in remission features lower-intensity treatments given over extended periods to improve disease outcomes. Targeted drugs are a natural fit for this space, and are the focus of considerable clinical investigation. This review summarizes recent advances in the field and their potential impact on treatment practices for MCL.
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA 98195, USA. yfengtin@fredhutch.org.|Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. yfengtin@fredhutch.org.
authors.forename: Fengting
authors.initials: F
authors.lastname: Yan
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA 98195, USA. agopal@uw.edu.|Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. agopal@uw.edu.
authors.forename: Ajay K
authors.initials: AK
authors.lastname: Gopal
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA 98195, USA. grafsa@uw.edu.|Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. grafsa@uw.edu.|Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA. grafsa@uw.edu.
authors.forename: Solomon A
authors.initials: SA
authors.lastname: Graf
keywords: maintenance therapy; mantle cell lymphoma; stem cell transplantation