title: Sorption-desorption test for functional assessment of skin treated with a lipid system that mimics epidermal lamellar bodies.
abstract: BACKGROUND
  Many skin diseases are associated with either increases or decreases in lamellar body secretion, or dysfunctional lamellar bodies. Consequently, diseased skin is characterized by reduced barrier function and altered lipid composition and organization. Human skin is commonly evaluated in vivo with non-invasive biophysical techniques. The dynamic functions of the skin are evaluated with repeat measurements such as the sorption-desorption test (SDT).
  
  
  OBJECTIVE
  The aim of this study was to evaluate in vivo skin hydration-dehydration kinetics after treatment with a lipid system that mimics the morphology, structure and composition of lamellar bodies in both healthy and irritated human skin.
  
  
  METHODS
  A patch with an aqueous solution of 2% sodium lauryl sulfate (SLS) was used to irritate the skin of the volunteers. The SDT was performed with the CM 820 corneometer.
  
  
  RESULTS
  After treatment with this system, both healthy and SLS-irritated skin increased their ability to retain water and to release water slowly during the desorption phase.
  
  
  CONCLUSIONS
  Treatment with this system seems to reinforce the barrier function in both healthy and SLS-irritated human skin. Therefore, the present study provides evidence that this system could be of interest for developing future treatments for protecting and repairing the skin.
authors.affiliation: Department of Chemical and Surfactant Technology, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), 08034, Barcelona, Spain.
authors.forename: Verónica
authors.identifier: http://orcid.org/0000-0003-1246-5713
authors.initials: V
authors.lastname: Moner
authors.affiliation: Bicosome S.L., 08034, Barcelona, Spain.
authors.forename: Estibalitz
authors.initials: E
authors.lastname: Fernández
authors.affiliation: Faculty of Pharmacy, Department of Pharmacy and Pharmaceutical Technology, University of Barcelona, 08028, Barcelona, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Del Pozo
authors.affiliation: Bicosome S.L., 08034, Barcelona, Spain.
authors.forename: Gelen
authors.initials: G
authors.lastname: Rodríguez
authors.affiliation: Bicosome S.L., 08034, Barcelona, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Cócera
authors.affiliation: Department of Chemical and Surfactant Technology, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), 08034, Barcelona, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: de la Maza
authors.affiliation: Department of Chemical and Surfactant Technology, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), 08034, Barcelona, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: López
mesh_terms: D000328:Adult; D017453:Dermatitis, Irritant / Q000175:diagnosis*; D004817:Epidermis / Q000378:metabolism; D005260:Female; D006801:Humans; D007509:Irritants / Q000008:administration & dosage; D050356:Lipid Metabolism; D008875:Middle Aged; D012869:Skin Absorption; D012879:Skin Physiological Phenomena; D012882:Skin Tests / Q000379:methods*; D014867:Water / Q000378:metabolism*
chemical_list: D007509:Irritants; D014867:Water
keywords: accumulated water decay (AWD); corneometer; skin lipids; sorption-desorption test; water sorption capacity (WSC); water-holding capacity (WHC)