title: Quantum mechanical model for the anticarcinogenic effect of extremely-low-frequency electromagnetic fields on early chemical hepatocarcinogenesis.
abstract: Using the conventional Haberkorn approach, it is evaluated the recombination of the radical pair (RP) singlet spin state to study theoretically the cytoprotective effect of an extremely-low-frequency electromagnetic field (ELF-EMF) on early stages of hepatic cancer chemically induced in rats. The proposal is that ELF-EMF modulates the interconversion rate of singlet and triplet spin states of the RP populations modifying the products from the metabolization of carcinogens. Previously, we found that the daily treatment with ELF-EMF 120 Hz inhibited the number and area of preneoplastic lesions in chemical carcinogenesis. The singlet spin population is evaluated diagonalizing the spin density matrix through the Lanczos method in a radical pair mechanism (RPM). Using four values of the interchange energy, we have studied the variations over the singlet population. The low magnetic field effect as a test of the influence over the enzymatic chemical reaction is evaluated calculating the quantum yield. Through a bootstrap technique the range is found for the singlet decay rate for the process. Applying the quantum measurements concept, we addressed the impact toward hepatic cells. The result contributes to improving our understanding of the chemical carcinogenesis process affected by charged particles that damage the DNA.
authors.affiliation: Departamento de Física CINVESTAV-IPN, Ap. Postal 14-740, CdMex, C.P. 07000, Mexico.
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Godina-Nava
authors.affiliation: Departamento de Física CINVESTAV-IPN, Ap. Postal 14-740, CdMex, C.P. 07000, Mexico.
authors.forename: Gabino
authors.initials: G
authors.lastname: Torres-Vega
authors.affiliation: Posgrado en Ciencias Cognitivas UAEM, Av. Universidad 1001, Col. Chamilpa, Cuernavaca Morelos, C.P. 62209, Mexico.
authors.forename: Germán Octavio
authors.initials: GO
authors.lastname: López-Riquelme
authors.affiliation: Departamento de Ciências Exatas e Tecnológicas, Universidade Estadual de Santa Cruz, Campus Soane Nazaré de Andrade, Rodovia Jorge Amado, Km 16, Bairro Salobrinho, 45662-900 Ilhéus, BA, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: López-Sandoval
authors.affiliation: Departamento de Ciências Exatas e Tecnológicas, Universidade Estadual de Santa Cruz, Campus Soane Nazaré de Andrade, Rodovia Jorge Amado, Km 16, Bairro Salobrinho, 45662-900 Ilhéus, BA, Brazil.
authors.forename: Arturo Rodolfo
authors.initials: AR
authors.lastname: Samana
authors.affiliation: Departamento de Ciências Exatas e Tecnológicas, Universidade Estadual de Santa Cruz, Campus Soane Nazaré de Andrade, Rodovia Jorge Amado, Km 16, Bairro Salobrinho, 45662-900 Ilhéus, BA, Brazil.
authors.forename: Fermín
authors.initials: F
authors.lastname: García Velasco
authors.affiliation: National Polytechnic Institute, Sepi-ESIME, Zacatenco, Professional Unit Adolfo López Mateos, Col. Lindavista, Cd Mex, C.P. 07738, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Hernández-Aguilar
authors.affiliation: National Polytechnic Institute, Sepi-ESIME, Zacatenco, Professional Unit Adolfo López Mateos, Col. Lindavista, Cd Mex, C.P. 07738, Mexico.
authors.forename: Arturo
authors.initials: A
authors.lastname: Domínguez-Pacheco
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004052:Diethylnitrosamine; D004195:Disease Models, Animal; D004574:Electromagnetic Fields; D022781:Hepatocytes / Q000201:enzymology; D008113:Liver Neoplasms / Q000201:enzymology / Q000628:therapy*; D055909:Magnetic Field Therapy; D008954:Models, Biological; D011789:Quantum Theory; D013997:Time Factors
chemical_list: D004052:Diethylnitrosamine; D003577:Cytochrome P-450 Enzyme System