title: Organocatalytic Enantioselective Michael/Cyclization Domino Reaction between 3-Amideoxindoles and α,β-Unsaturated Aldehydes: One-Pot Preparation of Chiral Spirocyclic Oxindole-γ-lactams.
abstract: The first organocatalytic enantioselective Michael/cyclization domino reaction between 3-amideoxindoles and α,β-unsaturated aldehydes is described. After sequential oxidation with pyridinium chlorochromate, a direct and one-pot preparation of highly sterically hindered spirocyclic oxindole-γ-lactams was achieved in 51-81% yields with 75-97% ee and ≤80/20 dr.
authors.affiliation: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu 610041, P. R. China.|University of Chinese Academy of Sciences , Beijing 100039, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yang
authors.affiliation: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu 610041, P. R. China.|University of Chinese Academy of Sciences , Beijing 100039, P. R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu 610041, P. R. China.|University of Chinese Academy of Sciences , Beijing 100039, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu 610041, P. R. China.|University of Chinese Academy of Sciences , Beijing 100039, P. R. China.
authors.forename: Zheng-Bing
authors.initials: ZB
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu 610041, P. R. China.|University of Chinese Academy of Sciences , Beijing 100039, P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu 610041, P. R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Peng
authors.affiliation: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu 610041, P. R. China.
authors.forename: Li-Xin
authors.identifier: 0000-0003-0830-7421
authors.initials: LX
authors.lastname: Wang