title: Naoxintong/PPARγSignaling Inhibits Cardiac Hypertrophy via Activation of Autophagy.
abstract: As a traditional Chinese medicine, Naoxintong capsule (NXT) has been approved by China Food and Drug Administration (CFDA), which is used for cardiocerebrovascular disease treatment. Here we found that NXT extract significantly promoted H9c2 cardiomyocyte cell autophagy involved in increased autophagy-associated gene expression leading to inhibition of mTOR signaling. Moreover, NXT extract increased PPARγprotein expression and transcription activity of H9c2 cell. Consistent with this, in PPARγgene silenced H9c2 cells, NXT had no effect on autophagy and mTOR signaling. Furthermore, NXT/PPARγ-mediated H9c2 autophagy led to inhibition of cardiomyocyte cell hypertrophy. These findings suggest that the extract of NXT inhibited H9c2 cardiomyocyte cell hypertrophy via PPARγ-mediated cell autophagy.
authors.affiliation: Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Yuan
authors.affiliation: Department of Oncology, Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 212017, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Jin
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Nankai District, Tianjin 300193, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.affiliation: Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
authors.forename: Yongzhong
authors.identifier: 0000-0003-2019-8686
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Nankai District, Tianjin 300193, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae (Tianjin University of Traditional Chinese Medicine), Ministry of Education, Tianjin 300193, China.
authors.forename: Hong
authors.identifier: 0000-0002-0253-8918
authors.initials: H
authors.lastname: Wang