title: Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine.
abstract: Mesenchymal stem cells (MSCs), as major stem cells for cell therapy, have been studied from different aspects in preclinical and clinical settings for more than a decade. These cells modulate the immune system (humoral and cellular immune responses) in vitro by producing soluble factors (anti-inflammatory molecules) and/or making cell-cell contacts. Hence, they could be used in regenerative medicine, tissue engineering and immune therapy. MSCs-based therapy have been recently used for treatment of cancer regarding the migratory potential of these cells towards tumor cells which makes them considerable candidates, also for cell therapy in both allogeneic and autologous settings. So, this review attempts to focus on the factors secreted by MSCs such as cytokines, their functional role in mounting and controlling immune responses mediated by different immune cell subpopulations and their significance in regenerative medicine in clinical trials. Although, further studies remain to be done to increase our knowledge of regulating development mechanisms, homeostasis and tissue repair in order to provide new tools to implement the efficacy of cell therapy trials. Although MSCs have been proved safe and effective for cell therapy, there are still challenges to overcome before widely applying MSCs in clinic.
authors.affiliation: Department of Health Education and Nutrition, Faculty of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Roghayeh
authors.initials: R
authors.lastname: Hosseinikia
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Nikbakht
authors.affiliation: College of Veterinary Medicine, Razi University, Kermanshah, Iran.
authors.forename: Ali Asghar
authors.initials: AA
authors.lastname: Moghaddam
authors.affiliation: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Tajehmiri
authors.affiliation: Department of Health Education and Nutrition, Faculty of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Mahboobe
authors.initials: M
authors.lastname: Hosseinikia
authors.affiliation: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Oubari
authors.affiliation: Iranian Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
authors.forename: Mahin
authors.initials: M
authors.lastname: Nikougoftar Zarif
authors.affiliation: Department of Health Education and Nutrition, Faculty of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Yahya
authors.initials: Y
authors.lastname: Pasdar
authors.affiliation: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Kamran
authors.initials: K
authors.lastname: Mansouri
keywords: Cell therapy; Immunomodulation; MSCs; Regeneration medicine; Soluble factors