title: Transporters Revealed.
abstract: The subfamily C ATP-binding cassette (ABCC) transporters mediate multidrug resistance and ion conductance regulation. Recent atomic or near-atomic resolution structures of three physiologically significant ABCC transporters (MRP1, SUR1, and CFTR), determined by using single-particle cryo-electron microscopy (cryo-EM), reveal structural details that help explain the wide functional diversity of this ABC transporter subfamily.
authors.affiliation: Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Jyh-Yeuan
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Electronic address: dan.rosenbaum@utsouthwestern.edu.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Rosenbaum
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000737:chemistry; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins
chemical_list: D018528:ATP-Binding Cassette Transporters; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins