title: Unilateral malignant optic glioma following glioblastoma multiforme in the young: a case report and literature review.
abstract: BACKGROUND
  Malignant optic gliomas are rare, but they rapidly become lethal visual pathway tumors. We present the clinical course, treatment, and prognosis of a case of unilateral malignant optic glioma in a young man with a history of brain glioblastoma multiforme (GBM).
  
  
  METHODS
  A 21-year-old man, who had GBM 7 years ago complained of a transient shadow in his vision and presented with normal visual acuity but optic disc edema and an enlarged blind spot in the right eye (oculus dexter, OD). Magnetic resonance imaging (MRI) showed a right intraorbital optic nerve tumor without a brain lesion. Chiasm involvement and severe vision deterioration occurred 3 months later. A biopsy of the right optic nerve revealed glioblastoma. Concurrent chemoradiotherapy (CCRT) prevented involvement of the fellow eye 1 year after symptom onset.
  
  
  CONCLUSIONS
  This report demonstrated that a regular ocular exam should be recommended for several years after GBM. In young healthy patients who are able to undergo chemotherapy and radiotherapy, visual function in the fellow eye can be preserved.
authors.affiliation: Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Kaohsiung, Taiwan.
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Lin
authors.affiliation: Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Kaohsiung, Taiwan. sammy1013@cgmh.org.tw.
authors.forename: Hsiu-Mei
authors.initials: HM
authors.lastname: Huang
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005909:Glioblastoma / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D020339:Optic Nerve Glioma / Q000175:diagnosis*; D055815:Young Adult
keywords: Glioblastoma multiforme; Malignant optic glioma; Optic disc edema; Young