title: Predicting Presynaptic and Postsynaptic Neurotoxins by Developing Feature Selection Technique.
abstract: Presynaptic and postsynaptic neurotoxins are proteins which act at the presynaptic and postsynaptic membrane. Correctly predicting presynaptic and postsynaptic neurotoxins will provide important clues for drug-target discovery and drug design. In this study, we developed a theoretical method to discriminate presynaptic neurotoxins from postsynaptic neurotoxins. A strict and objective benchmark dataset was constructed to train and test our proposed model. The dipeptide composition was used to formulate neurotoxin samples. The analysis of variance (ANOVA) was proposed to find out the optimal feature set which can produce the maximum accuracy. In the jackknife cross-validation test, the overall accuracy of 94.9% was achieved. We believe that the proposed model will provide important information to study neurotoxins.
authors.affiliation: Department of Pathophysiology, Southwest Medical University, Luzhou 646000, China.
authors.forename: Hua
authors.identifier: 0000-0001-6728-4544
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Anesthesiology, The Affiliated Traditional Chinese Medical Hospital of Southwest Medical University, Luzhou 646000, China.
authors.forename: Yunchun
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Pathophysiology, Southwest Medical University, Luzhou 646000, China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Pathophysiology, Southwest Medical University, Luzhou 646000, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Pathophysiology, Southwest Medical University, Luzhou 646000, China.
authors.forename: Po
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Pathophysiology, Southwest Medical University, Luzhou 646000, China.
authors.forename: Chenggang
authors.identifier: 0000-0002-3142-6296
authors.initials: C
authors.lastname: Duan
authors.affiliation: Department of Pathophysiology, Southwest Medical University, Luzhou 646000, China.
authors.forename: Ping
authors.identifier: 0000-0002-0699-8487
authors.initials: P
authors.lastname: Zou
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D019295:Computational Biology; D006801:Humans; D008962:Models, Theoretical; D009498:Neurotoxins / Q000737:chemistry* / Q000627:therapeutic use; D017729:Presynaptic Terminals / Q000737:chemistry / Q000187:drug effects*
chemical_list: D000596:Amino Acids; D009498:Neurotoxins