title: Organisation and assembly of the surface membrane during early cleavage of the mouse embryo.
abstract: An attempt was made to understand the ways in which 'newly inserted' membrane was organised in relation to existing membrane during early cleavage of the mouse embryo by (i) monitoring the redistribution of a variety of surface-binding ligands (applied to the embryo during the previous cell cycle) and (ii) analysing the localisation of newly synthesised lipid at defined stages during the second cell cycle. The membrane dynamics of the embryo appear similar to those of somatic cells during cytokinesis and/or motility, and are consistent with previous suggestions (Pratt 1985) that the main cytocortical domains of the polarised 8-cell blastomere may start to diverge during early cleavage as a result of localised assembly and reorganisation of the embryo cytocortex.
authors.affiliation: Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY, Cambridge, UK.
authors.forename: Hester P M
authors.initials: HP
authors.lastname: Pratt
authors.affiliation: Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY, Cambridge, UK.
authors.forename: Martin A
authors.initials: MA
authors.lastname: George
keywords: Cleavage; Membrane assembly; Mouse embryo