title: Regimes of Biomolecular Ultrasmall Nanoparticle Interactions.
abstract: Ultrasmall nanoparticles (USNPs), usually defined as NPs with core in the size range 1-3 nm, are a class of nanomaterials which show unique physicochemical properties, often different from larger NPs of the same material. Moreover, there are also indications that USNPs might have distinct properties in their biological interactions. For example, recent in vivo experiments suggest that some USNPs escape the liver, spleen, and kidney, in contrast to larger NPs that are strongly accumulated in the liver. Here, we present a simple approach to study the biomolecular interactions at the USNPs bio-nanointerface, opening up the possibility to systematically link these observations to microscopic molecular principles.
authors.affiliation: Centre for BioNano Interaction, University College Dublin, School of Chemistry, Belfield, Dublin, 4, Ireland.
authors.forename: Luca
authors.identifier: 0000-0002-2732-5484
authors.initials: L
authors.lastname: Boselli
authors.affiliation: Centre for BioNano Interaction, University College Dublin, School of Chemistry, Belfield, Dublin, 4, Ireland.
authors.forename: Ester
authors.identifier: 0000-0001-8870-5280
authors.initials: E
authors.lastname: Polo
authors.affiliation: Centre for BioNano Interaction, University College Dublin, School of Chemistry, Belfield, Dublin, 4, Ireland.
authors.forename: Valentina
authors.identifier: 0000-0002-8651-5958
authors.initials: V
authors.lastname: Castagnola
authors.affiliation: Centre for BioNano Interaction, University College Dublin, School of Chemistry, Belfield, Dublin, 4, Ireland.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Dawson
mesh_terms: D001826:Body Fluids / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry*; D015394:Molecular Structure; D010316:Particle Size; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008024:Ligands; D011506:Proteins; D006046:Gold
keywords: bioinorganic chemistry; electrophoresis; nanoparticles; proteins; proteomics