title: Pregnancy and delivery in a woman with severe haemophilia A.
abstract: : Severe form of haemophilia in women is an extremely rare condition. Owing to the rarity of the disease there are no precise recommendations concerning the optimal management of pregnancy and delivery in these patients. We are reporting the clinical course and management of a 30-year-old woman with a severe form of haemophilia A (factor VIII <1 IU/dl) during her first pregnancy and delivery. Antepartum, she was treated on demand by FVIII concentrate and she delivered at 37 weeks of gestation by cesarean section. In postpartal period an excellent control of bleeding was obtained by regularly administering FVIII concentrate for several days as well by concomitant use of tranexamic acid and oral contraceptive pills in the next 6 weeks.
authors.affiliation: aClinic of Haematology, Clinical Center of Serbia bMedical Faculty, University of Belgrade cClinic for Obstetrics and Gynaecology, Clinical Center of Serbia, Belgrade, Serbia.
authors.forename: Jelena N
authors.initials: JN
authors.lastname: Bodrozic
authors.forename: Predrag S
authors.initials: PS
authors.lastname: Miljic
authors.forename: Danijela R
authors.initials: DR
authors.lastname: Lekovic
authors.forename: Milos A
authors.initials: MA
authors.lastname: Petronijevic
authors.forename: Darko A
authors.initials: DA
authors.lastname: Antic
authors.forename: Mirjana M
authors.initials: MM
authors.lastname: Mitrovic
authors.forename: Svetlana M
authors.initials: SM
authors.lastname: Petronijevic-Vrzic
authors.forename: Irena S
authors.initials: IS
authors.lastname: Djunic
mesh_terms: D000328:Adult; D005169:Factor VIII / Q000627:therapeutic use; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy*; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D014148:Tranexamic Acid / Q000627:therapeutic use
chemical_list: D014148:Tranexamic Acid; C078147:F8 protein, human; D005169:Factor VIII