title: Microbe-Induced Inflammatory Signals Triggering Acquired Bone Marrow Failure Syndromes.
abstract: Acquired bone marrow failure syndromes encompass a unique set of disorders characterized by a reduction in the effective production of mature cells by the bone marrow (BM). In the majority of cases, these syndromes are the result of the immune-mediated destruction of hematopoietic stem cells or their progenitors at various stages of differentiation. Microbial infection has also been associated with hematopoietic stem cell injury and may lead to associated transient or persistent BM failure, and recent evidence has highlighted the potential impact of commensal microbes and their metabolites on hematopoiesis. We summarize the interactions between microorganisms and the host immune system and emphasize how they may impact the development of acquired BM failure.
authors.affiliation: Department of Hematology and Oncology, Graduate School of Medical Science, Kanazawa University , Kanazawa, Ishikawa , Japan.
authors.forename: J Luis
authors.initials: JL
authors.lastname: Espinoza
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center , Boston, MA , USA.
authors.forename: Ritesh
authors.initials: R
authors.lastname: Kotecha
authors.affiliation: Department of Hematology and Oncology, Graduate School of Medical Science, Kanazawa University , Kanazawa, Ishikawa , Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
keywords: aplastic anemia; bone marrow failure syndromes; microbe immunity; microbioma; virus-induced anemia