title: Achievement of saturation targets in preterm infants <32 weeks' gestational age in the delivery room.
abstract: BACKGROUND
  To reduce the risks of hypoxia and hyperoxia in preterm infants in the delivery room; national and international guidelines recommend titrating supplemental oxygen delivery to achieve specific oxygen saturation (SpO2) targets. Our aim was to measure the proportion of time infants <32 weeks' gestation spent within and outside prescribed SpO2targets during the first 10 min after birth.
  
  
  METHODS
  Prospective observational study using data from a preductal SpO2sensor and oxygen analyser measuring fraction of inspired oxygen (FiO2) in the inspiratory limb of the respiratory circuit. Measurements of SpO2, heart rate and FiO2were recorded every 2 s. We assessed compliance with the upper SpO2limit only when infants were receiving supplemental oxygen. SpO2measurements were recorded as being below, within or above the target at each time point. We measured the number of times infants were continuously below or above the target range for more than 30 s.
  
  
  RESULTS
  Twenty-seven infants; mean (SD) 28 (3.4) weeks and 962 (370) g were studied. Infants were below, within and above the prescribed targets for 28%, 35% and 37% of the first 10 min after birth, respectively.
  
  
  CONCLUSIONS
  Preterm infants spent almost two-thirds of the first 10 min after birth with oxygen saturations outside prescribed target ranges. New titration strategies are required to reduce the risks of hypoxia and hyperoxia.
authors.affiliation: The Royal Melbourne Hospital Academic Centre, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Lani Nui
authors.initials: LN
authors.lastname: White
authors.affiliation: Newborn Research Centre, The Royal Women's Hospital, Melbourne, Victoria, Australia.|Murdoch Children's Research Institute, Parkville, Victoria, Australia.|The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Marta
authors.initials: M
authors.lastname: Thio
authors.affiliation: Newborn Research Centre, The Royal Women's Hospital, Melbourne, Victoria, Australia.|Murdoch Children's Research Institute, Parkville, Victoria, Australia.|The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Louise S
authors.initials: LS
authors.lastname: Owen
authors.affiliation: Newborn Research Centre, The Royal Women's Hospital, Melbourne, Victoria, Australia.|Murdoch Children's Research Institute, Parkville, Victoria, Australia.|The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: C Omar
authors.initials: CO
authors.lastname: Kamlin
authors.affiliation: The Royal Melbourne Hospital Academic Centre, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Samantha
authors.initials: S
authors.lastname: Sloss
authors.affiliation: Hudson Institute of Medical Research, Clayton, Australia.
authors.forename: Stuart B
authors.initials: SB
authors.lastname: Hooper
authors.affiliation: Newborn Research Centre, The Royal Women's Hospital, Melbourne, Victoria, Australia.|Murdoch Children's Research Institute, Parkville, Victoria, Australia.|The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Davis
authors.affiliation: Newborn Research Centre, The Royal Women's Hospital, Melbourne, Victoria, Australia.|Murdoch Children's Research Institute, Parkville, Victoria, Australia.|The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Dawson
mesh_terms: D003696:Delivery Rooms; D005260:Female; D005865:Gestational Age; D006339:Heart Rate; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010092:Oximetry; D010102:Oxygen Inhalation Therapy; D011446:Prospective Studies; D013997:Time Factors
keywords: Resuscitation; delivery room; heart rate; oxygen saturation; preterm infant