title: Multiresponsive Vesicles Composed of Amphiphilic Azacalix[4]pyridine Derivatives.
abstract: Biomimicry of multiresponsive recognition of cell membrane with artificial membranes is challengeable. In this work, we designed azacalix[4]pyridine-based amphiphilic molecules 1 and 2. The self-assembly behaviors of 1 and 2 were investigated in aqueous medium. As demonstrated by DLS, SEM, TEM, and LSCM measurements, 1 formed stable vesicles (size 322 nm) in a mixture of THF/water, whereas 2 produced giant vesicles with decreased stability (size 928 nm). The vesicles composed of 1, with surface being engineered with the cavities of azacalix[4]pyridines, showed selective responses to a variety of guests including zinc ion, hydroquinone, and proton as monitored by DLS.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Shi-Xin
authors.initials: SX
authors.lastname: Fa
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Wang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Qi-Qiang
authors.identifier: http://orcid.org/0000-0001-5988-1293
authors.initials: QQ
authors.lastname: Wang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Yu-Fei
authors.initials: YF
authors.lastname: Ao
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: De-Xian
authors.identifier: http://orcid.org/0000-0002-9059-5022
authors.initials: DX
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Mei-Xiang
authors.identifier: http://orcid.org/0000-0001-7112-0657
authors.initials: MX
authors.lastname: Wang
keywords: amphiphile; azacalix[4]pyridine; heteracalixaromatics; multiresponsive; vesicle