title: Phenolic constituents from Rheum nobile and their antioxidant activity.
abstract: Although the rhizomes of Rheum nobile Hook. f. et Thoms (Polygonaceae) are widely used in Tibetan medicine, no previous investigations regarding the biological activities and rarely chemical constituents of this plant have been reported. As part of an ongoing search for novel bioactive agents, a phytochemical investigation of R. nobile led to the isolation of two new compounds Rheumone B (1) and piceatannol-4'-O-β-D-(6″-O-acetyl)-glucoside (2), together with 15 known compounds by gel filtration over Sephadex LH-20 and preparative HPLC. Their structures were determined by combined spectroscopic methods. Compounds 1-10 were evaluated for their ability to scavenge 2,2-diphenyl-1-picrylhydzyl (DPPH) radical and compounds 7-10 showed relatively strong scavenging abilities with IC50values from 2.76 μM to 11.80 μM. In conclusion, naphthalene glycosides, stilbene glycosides, flavanols, especially anthraquinones are main chemical constituents of this plant. The ability to scavenge DPPH radical of compound 8 was the highest among compounds 1-10.
authors.affiliation: a School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Fei
authors.affiliation: a School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
authors.forename: Juan
authors.identifier: http://orcid.org/0000-0002-3202-6729
authors.initials: J
authors.lastname: Wang
authors.affiliation: b Beijing Institute of Traditional Chinese Medicine, Beijing Hospital of Traditional Chinese Medicine , Affiliated to Capital Medical University , Beijing , China.
authors.forename: Bing
authors.initials: B
authors.lastname: Peng
authors.affiliation: c Department of Chemistry and Biochemistry , University of North Carolina at Wilmington , Wilmington , NC , USA.
authors.forename: Jiangnan
authors.initials: J
authors.lastname: Peng
authors.affiliation: d School of Basic Medical Science , Beijing University of Chinese Medicine , Beijing , China.
authors.forename: Jing-Hong
authors.initials: JH
authors.lastname: Hu
authors.affiliation: b Beijing Institute of Traditional Chinese Medicine, Beijing Hospital of Traditional Chinese Medicine , Affiliated to Capital Medical University , Beijing , China.
authors.forename: Zu-Ping
authors.initials: ZP
authors.lastname: Zeng
authors.affiliation: e Department of Tibetan medicine , Tibetan Traditional Medical College , Lhasa , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: e Department of Tibetan medicine , Tibetan Traditional Medical College , Lhasa , China.
authors.forename: Qi-En
authors.initials: QE
authors.lastname: Li
authors.affiliation: a School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
authors.forename: Zeng-Ping
authors.initials: ZP
authors.lastname: Gao
authors.affiliation: d School of Basic Medical Science , Beijing University of Chinese Medicine , Beijing , China.
authors.forename: Xing-Li
authors.initials: XL
authors.lastname: Yan
mesh_terms: D000880:Anthraquinones / Q000737:chemistry; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D064209:Phytochemicals; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry; D012250:Rheum / Q000737:chemistry
chemical_list: D000880:Anthraquinones; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006027:Glycosides; D010636:Phenols; D064209:Phytochemicals; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Rheum nobile; antioxidant activity; phenolic constituents