title: Suspected Heparin-Induced Thrombocytopenia in Patients Receiving Extracorporeal Membrane Oxygenation.
abstract: Heparin-induced thrombocytopenia (HIT) is an immune reaction usually secondary to unfractionated heparin. Anticoagulation management is critical in patients while on extracorporeal membrane oxygenation (ECMO) to prevent thromboembolism and for the optimal functioning of the circuit. We identified five patients with respiratory failure at our hospital managed with ECMO in the last 2 years that were treated for HIT. A brief clinical course and their management are discussed. We also briefly review the literature for best evidence for management of such patients.
authors.affiliation: Division of Pulmonary, Allergy, Critical Care and Sleep, University of Arizona Medical Center, Tucson, Arizona.
authors.forename: Bhupinder
authors.initials: B
authors.lastname: Natt
authors.affiliation: Division of Pulmonary, Allergy, Critical Care and Sleep, University of Arizona Medical Center, Tucson, Arizona; Department of Emergency Medicine, University of Arizona Medical Center, Tucson, Arizona.
authors.forename: Cameron
authors.initials: C
authors.lastname: Hypes
authors.affiliation: College of Pharmacy, University of Arizona, Tucson, Arizona.
authors.forename: Robyn
authors.initials: R
authors.lastname: Basken
authors.affiliation: Division of Pulmonary, Allergy, Critical Care and Sleep, University of Arizona Medical Center, Tucson, Arizona.
authors.forename: Joshua
authors.initials: J
authors.lastname: Malo
authors.affiliation: Department of Cardiothoracic Surgery, University of Arizona Medical Center, Tucson, Arizona.
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Kazui
authors.affiliation: Division of Pulmonary, Allergy, Critical Care and Sleep, University of Arizona Medical Center, Tucson, Arizona; Department of Emergency Medicine, University of Arizona Medical Center, Tucson, Arizona.
authors.forename: Jarrod
authors.initials: J
authors.lastname: Mosier
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects; D003937:Diagnosis, Differential; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006493:Heparin / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000628:therapy*; D013927:Thrombosis / Q000150:complications / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006493:Heparin
keywords: ECMO; HIT; antibody; anticoagulation