title: [Perforated peptic ulcer closure: laparoscopic or open?]
abstract: OBJECTIVE
  To compare laparoscopic and open closure of perforated peptic ulcer (PPU).
  
  
  METHODS
  The study included 153 patients who underwent PPU suturing. 78 patients underwent laparoscopic closure (laparoscopic group) and open suturing via upper midline laparotomy was performed in 75 cases (open group). Surgery time, postoperative pain severity, time of analgesics intake, postoperative complications, hospital-stay and and cosmetic effect were compared.
  
  
  RESULTS
  Laparoscopic PPU closure may be effective and accessible in experienced endoscopic surgeon. It significantly reduces postoperative pain severity, need for analgesics, incidence of postoperative complications and provides excellent cosmetic effect. However, there is greater time of surgery compared with open intervention. There were no significant differences in hspital-stay between groups.
  
  
  CONCLUSIONS
  Laparoscopic PPU suturing can be considered a good alternative to open surgery. Further researches are needed for standardization, assessment of safety, real advantages and disadvantages of laparoscopic technique.
authors.affiliation: Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation.
authors.forename: A V
authors.initials: AV
authors.lastname: Alekberzade
authors.affiliation: Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation.
authors.forename: N N
authors.initials: NN
authors.lastname: Krylov
authors.affiliation: Topchubashov Research Center of Surgery, Ministry of Health of the Azerbaijan Republic, Baku.
authors.forename: E A
authors.initials: EA
authors.lastname: Rustamov
authors.affiliation: Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation.
authors.forename: D A
authors.initials: DA
authors.lastname: Badalov
authors.affiliation: Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation.
authors.forename: M A
authors.initials: MA
authors.lastname: Popovtsev
mesh_terms: D000368:Aged; D057186:Comparative Effectiveness Research; D013505:Digestive System Surgical Procedures / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods; D007813:Laparotomy / Q000009:adverse effects / Q000379:methods; D008297:Male; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care; D010439:Peptic Ulcer Perforation / Q000175:diagnosis / Q000601:surgery; D019990:Perioperative Care / Q000379:methods; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D012426:Russia; D058106:Wound Closure Techniques / Q000009:adverse effects