title: Pilot cohort study on the potential role of TCF7L2 rs7903146 on ischemic heart disease among non-diabetic kidney transplant recipients.
abstract: TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated. On this basis, we investigated its association with major adverse cardiac events (MACE) in a single-center cohort of non-diabetic kidney transplant recipients (KTRs).
  
  
  
  Patients with pretransplant diabetes were excluded and patients who developed post-transplant diabetes were censored at time of diagnosis.
  
  
  
  rs7903146 C>T polymorphism appeared to modulate the risk of MACE: 5-year prevalence was 0.8% in CC patients, 7.2% in CT patients and 9.7% in TT patients (P<.001). TCF7L2 rs7903146 was an independent predictor of MACE in a multivariate Cox regression model (for each T allele, HR: 2.99, 95%CI: 1.62-5.52, P<.001), together with history of cardiac ischemic events (HR: 8.69, 95%CI: 3.57-21.16, P<.001), DGF (HR: 2.42, 95%CI: 0.98-5.95, P=.056) and HLA-mismatches (for each mismatch: HR: 1.55, 95%CI: 1.00-2.43, P=.053). Introduction of rs7903146 C>T polymorphism into a model based on these clinical variables significantly increased predictive power for MACE (P=.003).
  
  
  
  TCF7L2 rs7903146 T allele may be strongly and independently associated with MACE in non-diabetic KTRs. These findings suggest the possibility of employing this SNP to more accurately stratify cardiological risk in KTRs.
authors.affiliation: Department of Translational Medicine, Nephrology and Kidney Transplant Unit, University of Piemonte Orientale, Novara, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Quaglia
authors.affiliation: Department of Translational Medicine, Nephrology and Kidney Transplant Unit, University of Piemonte Orientale, Novara, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Musetti
authors.affiliation: Department of Translational Medicine, Nephrology and Kidney Transplant Unit, University of Piemonte Orientale, Novara, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Merlotti
authors.affiliation: Dipartimento di Scienze del Farmaco & Centro di Ricerca Interdipartimentale di Farmacogenetica e Farmacogenomica (CRIFF), University of Piemonte Orientale, Novara, Italy.
authors.forename: Armando A
authors.initials: AA
authors.lastname: Genazzani
authors.affiliation: Dipartimento di Scienze del Farmaco & Centro di Ricerca Interdipartimentale di Farmacogenetica e Farmacogenomica (CRIFF), University of Piemonte Orientale, Novara, Italy.
authors.forename: Sarah
authors.initials: S
authors.lastname: Cargnin
authors.affiliation: Unit of Medical Statistics and Cancer Epidemiology, University of Piemonte Orientale and CPO Piemonte, Novara, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Cena
authors.affiliation: Department of Translational Medicine, Nephrology and Kidney Transplant Unit, University of Piemonte Orientale, Novara, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cantaluppi
authors.affiliation: Dipartimento di Scienze del Farmaco & Centro di Ricerca Interdipartimentale di Farmacogenetica e Farmacogenomica (CRIFF), University of Piemonte Orientale, Novara, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Terrazzino
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology* / Q000473:pathology; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*
chemical_list: C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein
keywords: TCF7L2; acute myocardial infarction; coronary artery disease; coronary heart disease; kidney transplantation; rs7903146