title: Comparison of Blood Viscoelasticity in Pediatric and Adult Cardiac Patients.
abstract: Evidence is accumulating that blood flow patterns in the cardiovascular system and in cardiovascular devices do, in some instances, depend on blood viscoelasticity. Thus, to better understand the challenges to providing circulatory support and surgical therapies for pediatric and adult patients, viscous and elastic components of complex blood viscoelasticity of 31 pediatric patients were compared to those of 29 adult patients with a Vilastic-3 rheometer. A random effects model with categorical age covariates found statistically significant differences between pediatric and adult patients for log viscosity (p = 0.005). Log strain (p < 0.0001) and hematocrit (p < 0.0001) effects were also significant, as were the hematocrit-by-log-strain (p = 0.0006) and age-by-log strain (p = 0.001) interactions. The hematocrit-by-age interaction was not significant. For log elasticity, age differences were insignificant (p = 0.39). The model for log elasticity had significant log strain (p < 0.0001), log strain squared (p < 0.0001) and hematocrit (p < 0.0001) effects, as well as hematocrit-by-log-strain and hematocrit-by-log-strain-squared interactions (p = 0.014). A model for log viscosity with continuous age was also fit to the data, which can be used to refine cardiovascular device design and operation to the age of the patient. We conclude that there are distinct differences between pediatric and adult blood viscosity, as well as substantial variation within the pediatric population, that may impact the performance of devices and procedures.
authors.affiliation: Department of Mechanical Engineering, University of Louisville, 200 Sackett Hall, Louisville, KY, 40292, USA. keith.sharp@louisville.edu.
authors.forename: M Keith
authors.initials: MK
authors.lastname: Sharp
authors.affiliation: School of Public Health, University of Louisville, Louisville, KY, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Gregg
authors.affiliation: School of Public Health, University of Louisville, Louisville, KY, USA.
authors.forename: Guy
authors.initials: G
authors.lastname: Brock
authors.affiliation: Department of Mechanical Engineering, University of Louisville, 200 Sackett Hall, Louisville, KY, 40292, USA.
authors.forename: Neema
authors.initials: N
authors.lastname: Nair
authors.affiliation: Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.
authors.forename: Sarina
authors.initials: S
authors.lastname: Sahetya
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, KY, USA.
authors.forename: Erle H
authors.initials: EH
authors.lastname: Austin
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, KY, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Mascio
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, KY, USA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Slaughter
authors.affiliation: Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.|Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, KY, USA.
authors.forename: George M
authors.initials: GM
authors.lastname: Pantalos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001809:Blood Viscosity; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D004548:Elasticity; D006331:Heart Diseases / Q000097:blood* / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged
keywords: Adult; Blood; Elasticity; Hematocrit; Pediatric; Viscosity