title: CSF analysis for protein biomarker identification in patients with leptomeningeal metastases from CNS lymphoma.
abstract: Leptomeningeal metastases (LM) from lymphoma remain a difficult complication for oncologist due to the high incidence in morbidity and mortality. Early diagnostic and initiation of treatment are essential to prevent neurological deterioration. Areas covered: In this review, several proteomic approaches are described in order to help and provide the basis for the identification of biomarkers useful in early diagnosis, also in discovery novel targets for therapeutic agents. In fact, the identification of biomarkers will have a high potential to detect leptomeningeal lymphoma, as well as to predict its progression and treatment response. Expert commentary: In the case of LM by Central nervous system (CNS) lymphoma, these studies generated the first insights into the utility of proteomic analysis for biomarker identification and will be demonstrated that identifying specific proteins in cerebrospinal fluid (CSF) had much greater sensitivity for detecting LM in comparison to standard cytological protocols.
authors.affiliation: a Proteomics Unit , Cancer Research Centre, IBSAL, University of Salamanca-CSIC , Salamanca , Spain.
authors.forename: N
authors.initials: N
authors.lastname: Galicia
authors.affiliation: a Proteomics Unit , Cancer Research Centre, IBSAL, University of Salamanca-CSIC , Salamanca , Spain.
authors.forename: R
authors.initials: R
authors.lastname: Dégano
authors.affiliation: a Proteomics Unit , Cancer Research Centre, IBSAL, University of Salamanca-CSIC , Salamanca , Spain.|b Department of Medicine and General Service of Cytometry , Cancer Research Centre, IBSAL, University of Salamanca-CSIC , Salamanca , Spain.
authors.forename: P
authors.initials: P
authors.lastname: Díez
authors.affiliation: a Proteomics Unit , Cancer Research Centre, IBSAL, University of Salamanca-CSIC , Salamanca , Spain.|b Department of Medicine and General Service of Cytometry , Cancer Research Centre, IBSAL, University of Salamanca-CSIC , Salamanca , Spain.
authors.forename: M
authors.initials: M
authors.lastname: González-González
authors.affiliation: b Department of Medicine and General Service of Cytometry , Cancer Research Centre, IBSAL, University of Salamanca-CSIC , Salamanca , Spain.
authors.forename: R
authors.initials: R
authors.lastname: Góngora
authors.affiliation: a Proteomics Unit , Cancer Research Centre, IBSAL, University of Salamanca-CSIC , Salamanca , Spain.
authors.forename: N
authors.initials: N
authors.lastname: Ibarrola
authors.affiliation: a Proteomics Unit , Cancer Research Centre, IBSAL, University of Salamanca-CSIC , Salamanca , Spain.|b Department of Medicine and General Service of Cytometry , Cancer Research Centre, IBSAL, University of Salamanca-CSIC , Salamanca , Spain.
authors.forename: M
authors.initials: M
authors.lastname: Fuentes
mesh_terms: D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid*; D016543:Central Nervous System Neoplasms / Q000134:cerebrospinal fluid* / Q000235:genetics / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000134:cerebrospinal fluid* / Q000235:genetics / Q000473:pathology; D040901:Proteomics
chemical_list: D014408:Biomarkers, Tumor
keywords: Leptomeningeal Lymphoma; biomarkers; cerebrospinal fluid; proteins; proteomics