title: Neurogenic Effects of Ghrelin on the Hippocampus.
abstract: Mammalian neurogenesis continues throughout adulthood in the subventricular zone of the lateral ventricle and in the subgranular zone of the dentate gyrus in the hippocampus. It is well known that hippocampal neurogenesis is essential in mediating hippocampus-dependent learning and memory. Ghrelin, a peptide hormone mainly synthesized in the stomach, has been shown to play a major role in the regulation of energy metabolism. A plethora of evidence indicates that ghrelin can also exert important effects on neurogenesis in the hippocampus of the adult brain. The aim of this review is to discuss the current role of ghrelin on the in vivo and in vitro regulation of neurogenesis in the adult hippocampus. We will also discuss the possible role of ghrelin in dietary restriction-induced hippocampal neurogenesis and the link between ghrelin-induced hippocampal neurogenesis and cognitive functions.
authors.affiliation: Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea. praise1107@naver.com.
authors.forename: Chanyang
authors.initials: C
authors.lastname: Kim
authors.affiliation: Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea. shysl@hanmail.net.
authors.forename: Sehee
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Pharmacology and Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul 02447, Korea. sjpark@khu.ac.kr.
authors.forename: Seungjoon
authors.initials: S
authors.lastname: Park
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D004032:Diet; D054439:Ghrelin / Q000378:metabolism*; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D007858:Learning; D008568:Memory; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism; D055495:Neurogenesis; D015398:Signal Transduction
chemical_list: D054439:Ghrelin
keywords: ghrelin; hippocampus; learning; memory; neurogenesis