title: Oculomotor Prediction: A Window into the Psychotic Mind.
abstract: Psychosis - an impaired contact with reality - is a hallmark of schizophrenia. Many psychotic symptoms are associated with disruptions in agency - the sense that 'I' cause my actions. A failure to predict sensory consequences of one's own actions may underlie agency disturbances. Such predictions rely on corollary discharge (CD) signals, 'copies' of movement commands sent to sensory regions prior to action execution. Here, we make a case that the oculomotor system is a promising model for understanding CD in psychosis, building on advances in our understanding of the behavioral and neurophysiological correlates of CD associated with eye movements. In this opinion article, we provide an overview of recent evidence for disturbed oculomotor CD in schizophrenia, potentially linking bizarre and disturbing psychotic experiences with basic physiological processes.
authors.affiliation: Department of Psychology, Michigan State University, East Lansing, MI, USA. Electronic address: kthakkar@msu.edu.
authors.forename: Katharine N
authors.initials: KN
authors.lastname: Thakkar
authors.affiliation: Department of Psychiatry and Behavioral Neurosciences, Brain Imaging Research Division, Wayne State University, Detroit, MI, USA.
authors.forename: Vaibhav A
authors.initials: VA
authors.lastname: Diwadkar
authors.affiliation: Bernstein Center for Computational Neuroscience and Department of Psychology, Humboldt Universität, 10099 Berlin, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Rolfs
mesh_terms: D005133:Eye Movements; D006801:Humans; D009068:Movement; D011618:Psychotic Disorders; D012559:Schizophrenia / Q000503:physiopathology*; D012677:Sensation