title: Benzofuran glycosides and coumarins from the bark of Streblus indicus (Bur.) Corner.
abstract: Two pairs of rare benzofuran glucoside epimers, indicuses A and B and indicuses C and D, three biogenetically related compounds indicuses E-G, and one coumarin indicus H, as well as 11 known compounds, were isolated from the bark of Streblus indicus (Bur.) Corner. The structures of indicuses A-H were elucidated by NMR and MS data, as well as by CD. (S)-Marmesinin exhibited moderate antimicrobial activity in vitro against Bacillus subtilis and Saccharomyces cerevisiae. 7,8-Dihydroxy-3-(3-methyl-2-butenyl) coumarin, umbelliferone, and scopoletin displayed strong cytotoxic activity in vitro against human bladder carcinoma cell line EJ. The structure-activity relationships indicate that hydroxylation at C-7 in the cytotoxic compounds is crucial to their activities.
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China; Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guilin, 541006, PR China.
authors.forename: Ruijie
authors.initials: R
authors.lastname: He
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
authors.forename: Liangdeng
authors.initials: L
authors.lastname: Wu
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Nie
authors.affiliation: Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Nanning, 530022, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Nanning, 530022, PR China.
authors.forename: Buming
authors.initials: B
authors.lastname: Liu
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
authors.forename: Shengping
authors.initials: S
authors.lastname: Deng
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
authors.forename: Ruiyun
authors.initials: R
authors.lastname: Yang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Huang
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Nong
authors.affiliation: State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China. Electronic address: lijun9593@gxnu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, PR China. Electronic address: czyzsu@163.com.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D001412:Bacillus subtilis / Q000187:drug effects; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012603:Scopoletin / Q000737:chemistry / Q000302:isolation & purification; D013329:Structure-Activity Relationship; D014468:Umbelliferones / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D003374:Coumarins; D005663:Furans; D006027:Glycosides; D010936:Plant Extracts; D014468:Umbelliferones; C495190:marmesinin; C031477:7-hydroxycoumarin; D012603:Scopoletin
keywords: Benzofuran glycoside; Coumarin; Cytotoxicity; Moraccae; Streblus indicus (Bur.) Corner; Streblus lour