title: The role for infarct volume as a surrogate measure of functional outcome following ischemic stroke.
abstract: The failed translation of proposed therapeutic agents for ischemic stroke from preclinical to clinical studies has led to increased scrutiny of preclinical studies, namely the model and outcome measures utilized. Preclinical studies routinely use infarct volume as an experimental endpoint or measure in studies employing young-adult, healthy male animals despite the fact that clinically, ischemic stroke is a disease of the elderly and improvements in functional outcome from pre- to post-intervention remains the most widely utilized assessment. The validity of infarct volume as a surrogate measure for functional outcome remains unclear in clinical studies as well as preclinical studies, particularly those utilizing a more clinically relevant aged thromboembolic model. In this work, we will address the relationship between acute and chronic functional outcome and infarct volume using a variety of functional assessments ranging from more simplistic, subjective measurements such as the modified Neurologic Severity Score (mNSS), to more complex, objective measurements such as grip strength and inclined plane.
authors.affiliation: Department of Neurosurgery, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Turner
authors.affiliation: Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: DiPasquale
authors.affiliation: Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, USA.
authors.forename: Aric F
authors.initials: AF
authors.lastname: Logsdon
authors.affiliation: Department of Neurosurgery, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA.
authors.forename: Zhenjun
authors.initials: Z
authors.lastname: Tan
authors.affiliation: Department of Neurosurgery, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA.
authors.forename: Zachary J
authors.initials: ZJ
authors.lastname: Naser
authors.affiliation: Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, USA.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Huber
authors.affiliation: Department of Neurosurgery, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA.
authors.forename: Charles L
authors.initials: CL
authors.lastname: Rosen
authors.affiliation: Department of Neurosurgery, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA.
authors.forename: Brandon P
authors.initials: BP
authors.lastname: Lucke-Wold
keywords: behavior; functional outcome; ischemic stroke