title: Ceftriaxone Etest non-susceptible methicillin susceptible Staphylococcus aureus time-kill responses.
abstract: We determined the correlation between Etest and BMD MICs with bactericidal activity in MSSA blood isolates. Ceftriaxone was bactericidal in 36% and 9% of isolates exposed to the Etest and BMD MIC, respectively. With the sub-optimal activity of ceftriaxone, the Etest MIC may be a conservative method in identifying clinical utility.
authors.affiliation: Department of Pharmacy, The Ohio State University Wexner Medical Center, 410 W 10th Ave Columbus, OH, 43210, USA.
authors.forename: Derek N
authors.initials: DN
authors.lastname: Bremmer
authors.affiliation: Department of Pathology, The Ohio State University Medical Center, 410 W 10th Ave Columbus, OH, 43210, USA.
authors.forename: Joan-Miquel
authors.initials: JM
authors.lastname: Balada-Llasat
authors.affiliation: Department of Pharmacy, The Ohio State University Wexner Medical Center, 410 W 10th Ave Columbus, OH, 43210, USA.
authors.forename: Debra A
authors.initials: DA
authors.lastname: Goff
authors.affiliation: Department of Pharmacy, The Ohio State University Wexner Medical Center, 410 W 10th Ave Columbus, OH, 43210, USA. Electronic address: Karri.Bauer@osumc.edu.
authors.forename: Karri A
authors.initials: KA
authors.lastname: Bauer
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D000077723:Cefepime; D002443:Ceftriaxone / Q000494:pharmacology*; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D002512:Cephalothin / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests / Q000379:methods*; D006801:Humans; D010068:Oxacillin / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D000097583:Ceftaroline
chemical_list: D000900:Anti-Bacterial Agents; D000077723:Cefepime; D002443:Ceftriaxone; D002444:Cefuroxime; D002511:Cephalosporins; D002512:Cephalothin; D010068:Oxacillin; D000097583:Ceftaroline
keywords: Antibiotic susceptibility testing methods; Bacteremia; Ceftriaxone; Staphylococcus aureus; Time-kill curves