title: The effects of parathyroid hormone peptides on the peripheral skeleton of postmenopausal women. A systematic review.
abstract: Given current developments in anabolic therapy for bone, we wished to document the effects of the only currently available anabolic therapy, parathyroid hormone (PTH) peptides, on the peripheral skeleton of postmenopausal women. We undertook a systematic review of English articles using MEDLINE, Scopus and the Cochrane Controlled Trials Register (final update 28th March 2016). Additional studies were identified through searches of bibliographies. Studies included those comparing PTH peptides with placebo, with anti-osteoporotic treatments and in combination therapies. Participants had to be postmenopausal women and outcomes included areal or volumetric bone mineral density (BMD) and measurements of bone microarchitecture at peripheral sites, such as the forearm and tibia. Data were extracted independently and reviewed by EVM and LMM. Data on study design were also collected for methodological risk of bias assessment. The heterogeneity between studies, regarding the drug dose and duration, and the site measured, prevented grouped meta-analysis. There were no significant differences in areal BMD between PTH peptides and placebo at peripheral skeletal sites at 12months. A decrease in aBMD occurred with PTH(1-34) (larger dose) and PTH(1-84) treatment at 18months follow-up in comparison to the placebo arms. Anti-resorptives seemed to attenuate losses of aBMD at peripheral sites when compared to PTH peptides monotherapy, likely mediated by lower cortical porosity. Finally, PTH peptides combined with bisphosphonates or denosumab attenuated peripheral BMD losses in comparison to PTH peptide monotherapy, with evidence of increased BMD at ultradistal peripheral sites when PTH(1-34) was combined with denosumab or hormone replacement therapy. This summary should act as a reference point for the comparison of new anabolic therapies, specifically in comparison to PTH(1-34).
authors.affiliation: MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), Department of Oncology and Metabolism, University of Sheffield, UK; Mellanby Centre for Bone Research, Department of Oncology and Metabolism, University of Sheffield, UK. Electronic address: lmmetcalf1@sheffield.ac.uk.
authors.forename: Louis M
authors.initials: LM
authors.lastname: Metcalf
authors.affiliation: Institute for Cellular Medicine, Newcastle University, UK. Electronic address: terry.aspray@newcastle.ac.uk.
authors.forename: Terry J
authors.initials: TJ
authors.lastname: Aspray
authors.affiliation: MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), Department of Oncology and Metabolism, University of Sheffield, UK; Mellanby Centre for Bone Research, Department of Oncology and Metabolism, University of Sheffield, UK. Electronic address: e.v.mccloskey@sheffield.ac.uk.
authors.forename: Eugene V
authors.initials: EV
authors.lastname: McCloskey
mesh_terms: D015519:Bone Density / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D006801:Humans; D010281:Parathyroid Hormone / Q000494:pharmacology*; D017698:Postmenopause
chemical_list: D010281:Parathyroid Hormone
keywords: Anabolics; Bone density; Osteoporosis; PTH peptides; Peripheral skeleton; Postmenopausal