title: Current state of the art for renal replacement therapy in critically ill patients with acute kidney injury.
abstract: Acute kidney injury (AKI) is associated with incremental risk for death and chronic kidney disease and represents a mounting clinical challenge for healthcare professionals. Renal replacement therapy (RRT) use in ICU settings is rising, likely in response to similar trends in AKI, taken together with an ageing population burdened by high prevalence of multi-morbidity and high illness acuity. Numerous features of RRT prescription and delivery are not standardized, nor are they supported from high-quality evidence derived from randomized trials. Despite the publication of rigorous clinical practice guidelines focused on RRT for AKI that are intended to optimize the quality and reliability of RRT in ICU settings, practice patterns and outcomes continue to show significant variability. In this concise review, we aim to summarize new knowledge and recent advances for the provision of RRT for critically ill patients with AKI.
authors.affiliation: Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 2-124E, Clinical Sciences Building, 8440-112 ST NW, Edmonton, T6G 2B7, Canada. bagshaw@ualberta.ca.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Bagshaw
authors.affiliation: Service de Reanimation Medicale, Hopital Nord, CHU Saint-Etienne, Ave. Albert Raimond, 42270 Saint-Prient-en-Jarez, EA3065, Saint-Etienne, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Darmon
authors.affiliation: Department of Critical Care and Nephrology, Guy's and St. Thomas Hospital, London, SE1 9RT, UK.
authors.forename: Marlies
authors.initials: M
authors.lastname: Ostermann
authors.affiliation: Yale University, New Haven, CT, USA.
authors.forename: Fredric O
authors.initials: FO
authors.lastname: Finkelstein
authors.affiliation: Division of Nephrology, St. Michael's Hospital, 30 Bond Street, Toronto, M5B 1W8, Canada.
authors.forename: Ron
authors.initials: R
authors.lastname: Wald
authors.affiliation: Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Ashita J
authors.initials: AJ
authors.lastname: Tolwani
authors.affiliation: Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7022, Cincinnati, OH, 45229, USA.
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Goldstein
authors.affiliation: Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.
authors.forename: David J
authors.initials: DJ
authors.lastname: Gattas
authors.affiliation: Intensive Care Unit, Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Shigehiko
authors.initials: S
authors.lastname: Uchino
authors.affiliation: Department of Intensive Care Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium.|Research Foundation-Flanders, Flanders, Belgium.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Hoste
authors.affiliation: Service de Reanimation Medico-Chirurgicale, Hopital Louise Mourier, Colombes, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: Gaudry
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D003422:Critical Care / Q000592:standards*; D016638:Critical Illness / Q000628:therapy*; D006801:Humans; D017410:Practice Guidelines as Topic; D017582:Renal Replacement Therapy / Q000592:standards*; D015203:Reproducibility of Results
keywords: Acute kidney injury; Citrate; Fluid overload; Modality; Peritoneal dialysis; Renal replacement therapy