title: Intratympanic methylprednisolone perfusion as a salvage treatment for profound idiopathic sudden sensorineural hearing loss.
abstract: OBJECTIVE
  This study aimed to examine the effectiveness of intratympanic methylprednisolone perfusion as salvage treatment for profound idiopathic sudden sensorineural hearing loss.
  
  
  METHODS
  A retrospective clinical study of 97 patients with unilateral profound idiopathic sudden sensorineural hearing loss was performed. In all, 83 patients who received salvage intratympanic methylprednisolone perfusion plus conventional treatment (except for steroids) as the second-line therapy were assigned to the study group, while 14 patients who received conventional treatment alone were assigned to the comparison group.
  
  
  RESULTS
  In the study group, treatments in patients with a shorter interval from disease onset to intratympanic methylprednisolone perfusion (up to 15 days) had significantly greater improvements in the overall effective rate and pure tone average compared with patients with a longer interval (over 15 days). For patients with a short interval from disease onset to intratympanic methylprednisolone perfusion, those in the study group had significantly greater improvements in the overall effective rate and pure tone average compared with those in the comparison group. In both the study and comparison groups, hearing improvements were greater at low frequencies than at medium and high frequencies.
  
  
  CONCLUSIONS
  The interval from disease onset to intratympanic methylprednisolone perfusion was the major factor affecting hearing recovery. Early second-line salvage intratympanic methylprednisolone perfusion significantly improved the degree of hearing recovery in profound idiopathic sudden sensorineural hearing loss patients after failure of systemic steroid treatment.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University,People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School,People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School,People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School,People's Republic of China.
authors.forename: X
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School,People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School,People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University,People's Republic of China.
authors.forename: W
authors.initials: W
authors.lastname: She
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy*; D003639:Hearing Loss, Sudden / Q000188:drug therapy*; D006801:Humans; D000069555:Injection, Intratympanic; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D016896:Treatment Outcome; D014432:Tympanic Membrane
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone
keywords:  Methylprednisolone; Hearing Loss; Perfusion; Salvage Therapy