title: Comparison of Ferric Sulfate Combined Mineral Trioxide Aggregate Pulpotomy and Zinc Oxide Eugenol Pulpectomy of Primary Maxillary Incisors: An 18-month Randomized, Controlled Trial.
abstract: OBJECTIVE
  The purpose of this study was to compare outcomes and survival of ferric sulfate with mineral trioxide aggregate (FS+MTA) pulpotomy and root canal therapy (RCT) in carious vital primary maxillary incisors.
  
  
  METHODS
  In this parallel group noninferiority trial, asymptomatic carious vital primary incisors with pulp exposure in healthy 18- to 46-month-olds were allocated randomly to receive FS+MTA pulpotomy or RCT between September 2010 and September 2012. Each incisor was classified into one of the following radiographic outcomes: N (incisor without pathologic change); Po (pathologic change present, follow-up recommended); Px (pathologic change present, extract.) Clinical findings and incisor survival were secondary outcomes.
  
  
  RESULTS
  Seventy subjects were enrolled with a total of 172 incisors. Twelve- and 18-month radiographic outcomes demonstrated no statistical difference between FS+MTA pulpotomy and RCT incisors for Px outcomes (P=0.38; odds ratio equals 0.60; 95 percent confidence interval equals 0.19 to 1.89; chi-square test). There was no statistical differences in clinical outcomes for FS+MTA pulpotomy and RCT at 12 and 18 months (P=0.51; Fisher's exact test) or survival for FS+MTA pulpotomy and RCT incisors (P=0.11; log-rank test).
  
  
  CONCLUSIONS
  Ferric Sulfate with Mineral Trioxide Aggregate (FS+MTA) is an alternative to RCT for vital primary incisors.
authors.affiliation: Division Chief, Pediatric Dentistry, Janeway Children's Health and Rehabilitation Centre, and a clinical assistant professor, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
authors.forename: Trang D
authors.initials: TD
authors.lastname: Nguyen
authors.affiliation: Dentist-in-Chief, Department of Dentistry, The Hospital for Sick Children, and an associate professor, Dentistry, University of Toronto, in Toronto, ON, Canada.
authors.forename: Peter L
authors.initials: PL
authors.lastname: Judd
authors.affiliation: Staff Pediatric Dentist, Department of Dentistry, The Hospital for Sick Children, and an assistant professor, Dentistry, University of Toronto, in Toronto, ON, Canada.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Barrett
authors.affiliation: Clinical Research Project Coordinator, The Hospital for Sick Children, in Toronto, ON, Canada.
authors.forename: Nicole
authors.initials: N
authors.lastname: Sidhu
authors.affiliation: Director of Clinics, Department of Dentistry, The Hospital for Sick Children, and an associate professor, Dentistry, University of Toronto, in Toronto, ON, Canada;, Email: michael.casas@sickkids.ca.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Casas
mesh_terms: D017607:Aluminum Compounds / Q000627:therapeutic use*; D017610:Calcium Compounds / Q000627:therapeutic use*; D002675:Child, Preschool; D004338:Drug Combinations; D005054:Eugenol / Q000627:therapeutic use*; D005260:Female; D005290:Ferric Compounds / Q000627:therapeutic use*; D006801:Humans; D007180:Incisor / Q000601:surgery*; D007223:Infant; D008297:Male; D008437:Maxilla; D010087:Oxides / Q000627:therapeutic use*; D011670:Pulpectomy / Q000379:methods*; D011672:Pulpotomy / Q000379:methods*; D012390:Root Canal Therapy / Q000379:methods; D017640:Silicates / Q000627:therapeutic use*; D014094:Tooth, Deciduous / Q000601:surgery; D015034:Zinc Oxide / Q000627:therapeutic use*
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D005290:Ferric Compounds; D010087:Oxides; D017640:Silicates; C086631:mineral trioxide aggregate; C024823:ferric sulfate; D005054:Eugenol; D015034:Zinc Oxide