title: Numerical modeling of hemodynamics scenarios of patient-specific coronary artery bypass grafts.
abstract: A fast computational framework is devised to the study of several configurations of patient-specific coronary artery bypass grafts. This is especially useful to perform a sensitivity analysis of the hemodynamics for different flow conditions occurring in native coronary arteries and bypass grafts, the investigation of the progression of the coronary artery disease and the choice of the most appropriate surgical procedure. A complete pipeline, from the acquisition of patient-specific medical images to fast parameterized computational simulations, is proposed. Complex surgical configurations employed in the clinical practice, such as Y-grafts and sequential grafts, are studied. A virtual surgery platform based on model reduction of unsteady Navier-Stokes equations for blood dynamics is proposed to carry out sensitivity analyses in a very rapid and reliable way. A specialized geometrical parameterization is employed to compare the effect of stenosis and anastomosis variation on the outcome of the surgery in several relevant cases.
authors.affiliation: MOX - Modeling and Scientific Computing, Dipartimento di Matematica, Politecnico di Milano, P.za Leonardo da Vinci 32, 20133, Milan, Italy. francesco.ballarin@sissa.it.|mathLab, Mathematics Area, SISSA, via Bonomea 265, 34136, Trieste, Italy. francesco.ballarin@sissa.it.
authors.forename: Francesco
authors.identifier: 0000-0001-6460-3538
authors.initials: F
authors.lastname: Ballarin
authors.affiliation: MOX - Modeling and Scientific Computing, Dipartimento di Matematica, Politecnico di Milano, P.za Leonardo da Vinci 32, 20133, Milan, Italy.|Computational Mechanics and Advanced Materials Group, Department of Civil Engineering and Architecture, University of Pavia, Via Ferrata 3, 27100, Pavia, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Faggiano
authors.affiliation: CMCS - Modelling and Scientific Computing, Ecole Polytechnique Fédérale de Lausanne, Station 8, 1015, Lausanne, Switzerland.
authors.forename: Andrea
authors.initials: A
authors.lastname: Manzoni
authors.affiliation: CMCS - Modelling and Scientific Computing, Ecole Polytechnique Fédérale de Lausanne, Station 8, 1015, Lausanne, Switzerland.
authors.forename: Alfio
authors.initials: A
authors.lastname: Quarteroni
authors.affiliation: mathLab, Mathematics Area, SISSA, via Bonomea 265, 34136, Trieste, Italy.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Rozza
authors.affiliation: Radiology Unit, Ospedale Luigi Sacco, Via G. B. Grassi 74, 20157, Milan, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Ippolito
authors.affiliation: Cardiovascular Surgery Unit, Ospedale Luigi Sacco, Via G. B. Grassi 74, 20157, Milan, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Antona
authors.affiliation: Cardiovascular Surgery Unit, Ospedale Luigi Sacco, Via G. B. Grassi 74, 20157, Milan, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Scrofani
mesh_terms: D003198:Computer Simulation; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000601:surgery*; D003331:Coronary Vessels / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular
keywords: Cardiovascular simulations; Computational reduction strategies; Coronary bypass grafts; Data assimilation; Geometrical parameterization; Patient-specific computing