title: [Effect of Fixed Lercanidipine/Enalapril Combination on 24-Hour Blood Pressure Profile in Elderly Patients With Arterial Hypertension].
abstract: We studied effect of therapy with fixed combination of lercanidipine and enalapril on 24-hour blood pressure (BP) profile in 34 elderly patients (mean age 76.4+/-5.2 years, 14 men, 20 women) with degree II hypertension. After clinical examination patients were given lercanidipine/enalapril combination (10/10 mg/day). The dose was increased to 10+20 mg/day when necessary. Assessment of efficacy was conducted on Rate of achievement of target BP [systolic (S) BP <150 mm HG, diastolic (D) BP<90 mmHg] and dynamics of parameters of 24-hour BP profile. Re-examinations were carried out on weeks 4.8 and 12 of treatment. Administration of lercanidipine/enalapril combination was associated with mean 24-hour SBP and DBP lowering (by15.3 and 8.7%, respectively). Diurnal and nocturnal SBP/DBP decreased by 15.7/ 9.2.
authors.affiliation: Voronezh State Medical Academy named after N.N. Burdenko of the Ministry of Public Health of the Russian Federation, Studencheskaya St., 394036 Voronezh, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Gosteva
authors.affiliation: Voronezh State Medical Academy named after N.N. Burdenko of the Ministry of Public Health of the Russian Federation, Studencheskaya St., 394036 Voronezh, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Vasileva