title: T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma.
abstract: BACKGROUND
  Hypertension remains to be a global public health burden and demands novel intervention strategies such as targeting T cells and T-cell-derived cytokines. Mineralocorticoid receptor (MR) antagonists have been clinically used to treat hypertension. However, the function of T-cell MR in blood pressure (BP) regulation has not been elucidated.
  
  
  OBJECTIVE
  We aim to determine the role of T-cell MR in BP regulation and to explore the mechanism.
  
  
  RESULTS
  Using T-cell MR knockout mouse in combination with angiotensin II-induced hypertensive mouse model, we demonstrated that MR deficiency in T cells strikingly decreased both systolic and diastolic BP and attenuated renal and vascular damage. Flow cytometric analysis showed that T-cell MR knockout mitigated angiotensin II-induced accumulation of interferon-gamma (IFN-γ)-producing T cells, particularly CD8+population, in both kidneys and aortas. Similarly, eplerenone attenuated angiotensin II-induced elevation of BP and accumulation of IFN-γ-producing T cells in wild-type mice. In cultured CD8+T cells, T-cell MR knockout suppressed IFN-γ expression whereas T-cell MR overexpression and aldosterone both enhanced IFN-γ expression. At the molecular level, MR interacted with NFAT1 (nuclear factor of activated T-cells 1) and activator protein-1 in T cells. Finally, T-cell MR overexpressing mice manifested more elevated BP compared with control mice after angiotensin II infusion and such difference was abolished by IFN-γ-neutralizing antibodies.
  
  
  CONCLUSIONS
  MR may interact with NFAT1 and activator protein-1 to control IFN-γ in T cells and to regulate target organ damage and ultimately BP. Targeting MR in T cells specifically may be an effective novel approach for hypertension treatment.
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Xue-Nan
authors.initials: XN
authors.lastname: Sun
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Lin-Juan
authors.initials: LJ
authors.lastname: Du
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Meng-Ru
authors.initials: MR
authors.lastname: Zeng
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Zheng
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Wu-Chang
authors.initials: WC
authors.lastname: Zhang
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Mingjiang
authors.initials: M
authors.lastname: Zhu
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Deping
authors.initials: D
authors.lastname: Kong
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Limin
authors.initials: L
authors.lastname: Lu
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Zhu-Xia
authors.initials: ZX
authors.lastname: Shen
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Yi
authors.initials: Y
authors.lastname: Yi
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Lili
authors.initials: L
authors.lastname: Du
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Mu
authors.initials: M
authors.lastname: Qin
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Zichun
authors.initials: Z
authors.lastname: Hua
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Shuyang
authors.initials: S
authors.lastname: Sun
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Huiyong
authors.initials: H
authors.lastname: Yin
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Ying
authors.initials: Y
authors.lastname: Yu
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.).
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital (S.S., Z.Z.), Shanghai Jiao Tong University School of Medicine, China; Institute for Nutritional Sciences (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., M.Z., D.K., Z.-X.S., H.Y., Y.Y.) and Institute of Biochemistry and Cell Biology (B.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, China; Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China (L.Z., L.L.); Department of Cardiology, Jing'an District Centre Hospital of Shanghai, Fudan University, China (Z.-X.S.); The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, China (Z.H.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China (Y.Y.). duansz@shsmu.edu.cn.
authors.forename: Sheng-Zhong
authors.initials: SZ
authors.lastname: Duan
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006973:Hypertension / Q000235:genetics / Q000378:metabolism; D007371:Interferon-gamma / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018161:Receptors, Mineralocorticoid / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D018161:Receptors, Mineralocorticoid; D007371:Interferon-gamma; D000109:Acetylcholine
keywords: T-cell; hypertension; inflammation; interferon-gamma; mineralocorticoid receptor