title: A Review of the Genetics of Hypertension with a Focus on Gene-Environment Interactions.
abstract: OBJECTIVE
  Here, we discuss the interpretation and modeling of gene-environment interactions in hypertension-related phenotypes, with a focus on the necessary assumptions and possible challenges.
  
  
  RESULTS
  Recently, small cohort studies have discovered several novel genetic variants associated with hypertension-related phenotypes through modeling gene-environment interactions. Several consortia-based meta-analytic efforts have uncovered many novel genetic variants in hypertension without modeling interaction terms, giving promise to future meta-analytic efforts that incorporate gene-environment interactions. Heritability studies and genome-wide association studies have established that hypertension, a prevalent cardiovascular disease, has a genetic component that may be modulated by the environment (such as lifestyle factors). This review includes a discussion of known genetic associations for hypertension/blood pressure, including those resulting from the incorporation of gene-environmental interaction modeling.
authors.affiliation: Division of Biostatistics, Washington University in St. Louis, School of Medicine, 660 S. Euclid Ave, Campus Box 8067, St. Louis, MO, 63110, USA. rjwaken@wustl.edu.
authors.forename: R J
authors.initials: RJ
authors.lastname: Waken
authors.affiliation: Division of Biostatistics, Washington University in St. Louis, School of Medicine, 660 S. Euclid Ave, Campus Box 8067, St. Louis, MO, 63110, USA.|Division of Cardiology, Department of Medicine, 660 S. Euclid Ave, Campus Box 8086, St. Louis, MO, 63110, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: de las Fuentes
authors.affiliation: Division of Biostatistics, Washington University in St. Louis, School of Medicine, 660 S. Euclid Ave, Campus Box 8067, St. Louis, MO, 63110, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Rao
mesh_terms: D001794:Blood Pressure / Q000235:genetics*; D004843:Epistasis, Genetic; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D010641:Phenotype
keywords: Cardiovascular disease; Gene-environment; Genetics of hypertension; Phenotypes