title: Genetic interaction between homoeotic Sex combs reduced and Regulator of bithorax (or trithorax) genes of Drosophila melanogaster.
abstract: Regulator of bithorax (Rg-bx)-, or trithorax (trx)-lethal larvae occasionally show a homoeotic transformation of the dorsal prothorax to mesothoracic structures. This transformation suggests a reduced activity of the Sex combs reduced (Scr) gene on the basis of gene dosage studies, as well as enhanced expression of the phenotypes of the weak Scr-alleles in Rg-bx-larvae. Morphological observations of adult flies doubly heterozygous for Rg-bx and Scr mutations also suggest the enhancement of an aspect of Scr adult phenotypes. I conclude that the Rg-bx+gene function is required for the optimal expression of the Scr gene in larval and imaginai cells.
authors.affiliation: Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, 186, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sato
keywords: Drosophila; Homoeotic genes; Segment differentiation