title: ADRB2 polymorphisms and dyslipidemia risk in Chinese hypertensive patients.
abstract: Single nucleotide polymorphisms (SNPs) within a β-adrenergic receptor (ADRB2) were shown to be related to lipid traits or hyperlipidemia in different ethnicities, but not in a Chinese population. We performed the present study to investigate the possible relationship between them in a Chinese hypertensive population. Seven hundred and eighty-three hypertensive subjects were enrolled in the hospital-based retrospective research. Using the TaqMan PCR method, three polymorphisms (C-47T, A46G, and C79G) of ADRB2 were detected. For the whole population, no significant statistical difference was found for all serum lipids. Similar findings were seen in men and women subgroups. Subsequently, in the case-control study, we observed that the A46G polymorphism was significantly associated with the elevated risk of hypertriglyceridemia in the dominant model (OR: 1.47, 95%CI: 1.05-2.06, P = 0.025). There are no significant differences in the other four models. With regard to C79G and C-47T, no significant association was seen in this population. In addition, haplotype analysis showed that the TAC haplotype carrying frequent alleles of the three SNPs played a reduced role in hypertriglyceridemia risk and the TGC haplotype carrying rare allele of A46G expressed a significant risk effect. In conclusion, these findings indicated that the ADRB2 SNPs might be a genetic risk factor for dyslipidemia in the Chinese hypertensive patients.
authors.affiliation: a Department of Hypertension Research , Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases , Beijing , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
authors.affiliation: a Department of Hypertension Research , Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases , Beijing , China.
authors.forename: Jilin
authors.initials: J
authors.lastname: Liu
authors.affiliation: a Department of Hypertension Research , Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases , Beijing , China.
authors.forename: Zuoguang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: a Department of Hypertension Research , Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases , Beijing , China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Department of Hypertension Research , Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases , Beijing , China.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Wen
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000097:blood / Q000150:complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000150:complications*; D015228:Hypertriglyceridemia / Q000097:blood / Q000150:complications / Q000235:genetics*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010641:Phenotype; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012189:Retrospective Studies; D012306:Risk; D014280:Triglycerides / Q000097:blood
chemical_list: C553443:ADRB2 protein, human; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D018343:Receptors, Adrenergic, beta-2; D014280:Triglycerides; D002784:Cholesterol
keywords: Chinese; lipid; polymorphism; β2 adrenergic receptor or ADRB2