title: Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease.
abstract: Cardiorespiratory fitness (CRF) has been shown to be related to brain health in older adults. In individuals at risk for developing Alzheimer's disease (AD), CRF may be a modifiable risk factor that could attenuate anticipated declines in brain volume and episodic memory. The objective of this study was to determine the association between CRF and both hippocampal volume and episodic memory in a cohort of cognitively healthy older adults with familial and/or genetic risk for Alzheimer's disease (AD).
  
  
  
  Eighty-six enrollees from the Wisconsin Registry for Alzheimer's Prevention participated in this study. Participants performed a graded maximal exercise test, underwent a T-1 anatomical magnetic resonance imaging scan, and completed the Rey Auditory Verbal Learning Test (RAVLT).
  
  
  
  There were no significant relationships between CRF and HV or RAVLT memory scores for the entire sample. When the sample was explored on the basis of gender, CRF was significantly associated with hippocampal volume for women. For men, significant positive associations were observed between CRF and RAVLT memory scores.
  
  
  
  These results suggest that CRF may be protective against both hippocampal volume and episodic memory decline in older adults at risk for AD, but that the relationships may be gender specific.
authors.affiliation: William S. Middleton Memorial Veterans Hospital Madison WI USA; Department of Kinesiology University of Wisconsin School of Education Madison WI USA.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Dougherty
authors.affiliation: Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Schultz
authors.affiliation: Department of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Boots
authors.affiliation: William S. Middleton Memorial Veterans Hospital Madison WI USA; Department of Kinesiology Iowa State University College of Human Sciences Ames IA USA.
authors.forename: Laura D
authors.initials: LD
authors.lastname: Ellingson
authors.affiliation: William S. Middleton Memorial Veterans Hospital Madison WI USA; Department of Family Medicine and Community Health University of Wisconsin Madison WI USA.
authors.forename: Jacob D
authors.initials: JD
authors.lastname: Meyer
authors.affiliation: William S. Middleton Memorial Veterans Hospital Madison WI USA; Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Van Riper
authors.affiliation: William S. Middleton Memorial Veterans Hospital Madison WI USA; Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA.
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Stegner
authors.affiliation: Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Dorothy F
authors.initials: DF
authors.lastname: Edwards
authors.affiliation: Department of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Oh
authors.affiliation: Division of Cardiology University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Jean
authors.initials: J
authors.lastname: Einerson
authors.affiliation: Division of Cardiology University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Claudia E
authors.initials: CE
authors.lastname: Korcarz
authors.affiliation: Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Koscik
authors.affiliation: Department of Biostatistics & Medical Informatics University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Maritza N
authors.initials: MN
authors.lastname: Dowling
authors.affiliation: Department of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Gallagher
authors.affiliation: Department of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Carlsson
authors.affiliation: Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA.
authors.forename: Howard A
authors.initials: HA
authors.lastname: Rowley
authors.affiliation: Department of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Barbara B
authors.initials: BB
authors.lastname: Bendlin
authors.affiliation: Department of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Asthana
authors.affiliation: Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA; Department of Neurology University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Bruce P
authors.initials: BP
authors.lastname: Hermann
authors.affiliation: Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Sager
authors.affiliation: Division of Cardiology University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: James H
authors.initials: JH
authors.lastname: Stein
authors.affiliation: Department of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Sterling C
authors.initials: SC
authors.lastname: Johnson
authors.affiliation: Department of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
authors.forename: Ozioma C
authors.initials: OC
authors.lastname: Okonkwo
authors.affiliation: William S. Middleton Memorial Veterans Hospital Madison WI USA; Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA.
authors.forename: Dane B
authors.initials: DB
authors.lastname: Cook
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D000072599:Cardiorespiratory Fitness / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D065840:Protective Factors; D012042:Registries; D012737:Sex Factors
keywords:  exercise; APOE‐e4; cognition; family history; physical activity