title: Management of mixed type congenital mesoblastic nephroma: Case series and review of the literature.
abstract: Congenital mesoblastic nephroma (CMN) is the most common renal tumor of infancy; however, it occurs infrequently with an incidence of 1 : 125,000. The cellular and classical variants are the most common subtypes of tumors, with a mixed variant occurring infrequently. We describe two cases of mixed variant CMN, which presented within days of each other differing in their clinical behavior. The first case followed a typical course, previously described in the literature, while the other deviated significantly. Traditionally, CMN presents as large abdominal mass in the neonatal period associated with a paraneoplastic syndrome, which can result in hypertension or hypercalcemia. Surgical resection is curative in most cases and long-term prognosis is excellent. Hypertension rarely persists after removal of the tumor, but remained in one of our two patients.
authors.affiliation: Department of Pediatrics, Division of Neonatology, College of Medicine, Univeristy of Kentucky, Lexington, KY, USA.
authors.forename: J
authors.initials: J
authors.lastname: Daniel
authors.affiliation: Department of Surgery, Division of Pediatric Surgery, College of Medicine, University of Kentucky, Lexington, KY, USA.
authors.forename: A
authors.initials: A
authors.lastname: Ruzic
authors.affiliation: Department of Pathology, College of Medicine, Univeristy of Kentucky, Lexington KY, USA.
authors.forename: J
authors.initials: J
authors.lastname: Dalland
authors.affiliation: Department of Pathology, College of Medicine, Univeristy of Kentucky, Lexington KY, USA.
authors.forename: V
authors.initials: V
authors.lastname: Miller
authors.affiliation: Department of Pediatrics, Division of Neonatology, College of Medicine, Univeristy of Kentucky, Lexington, KY, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hanna
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007231:Infant, Newborn; D007234:Infant, Premature; D007680:Kidney Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008197:Lymph Node Excision; D008279:Magnetic Resonance Imaging; D008297:Male; D009392:Nephrectomy; D018201:Nephroma, Mesoblastic / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D010257:Paraneoplastic Syndromes / Q000209:etiology; D011247:Pregnancy; D011859:Radiography
keywords: Neonate; abdominal mass; congenital mesoblastic nephroma