title: The influence of metabolic imbalances and oxidative stress on the outcome of critically ill polytrauma patients: a review.
abstract: The critically ill polytrauma patient presents with a series of associated pathophysiologies secondary to the traumatic injuries. The most important include systemic inflammatory response syndrome (SIRS), sepsis, oxidative stress (OS), metabolic disorders, and finally multiple organ dysfunction syndrome (MODS) and death. The poor outcome of these patients is related to the association of the aforementioned pathologies. The nutrition of the critically ill polytrauma patient is a distinct challenge because of the rapid changes in terms of energetic needs associated with hypermetabolism, sepsis, SIRS, and OS. Moreover, it has been proven that inadequate nutrition can prolong the time spent on a mechanical ventilator and the length of stay in an intensive care unit (ICU). A series of mathematical equations can predict the energy expenditure (EE), but they have disadvantages, such as the fact that they cannot predict the EE accurately in the case of patients with hypermetabolism. Indirect calorimetry (IC) is another method used for evaluating and monitoring the energy status of critically ill patients. In this update paper, we present a series of pathophysiological aspects associated with the metabolic disaster affecting the critically ill polytrauma patient. Furthermore, we present different non-invasive monitoring methods that could help the intensive care physician in the adequate management of this type of patient.
authors.affiliation: Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Str. Eftimie Murgu Nr. 2, Timisoara, 300041 Timis Romania.|Clinic of Anaesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Bd. Liviu Rebreanu Nr.156, Timisoara, 300736 Timis Romania.
authors.forename: Alexandru Florin
authors.identifier: 0000-0003-1286-4431
authors.initials: AF
authors.lastname: Rogobete
authors.affiliation: Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Str. Eftimie Murgu Nr. 2, Timisoara, 300041 Timis Romania.|Clinic of Anaesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Bd. Liviu Rebreanu Nr.156, Timisoara, 300736 Timis Romania.
authors.forename: Dorel
authors.initials: D
authors.lastname: Sandesc
authors.affiliation: Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Str. Eftimie Murgu Nr. 2, Timisoara, 300041 Timis Romania.|Clinic of Anaesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Bd. Liviu Rebreanu Nr.156, Timisoara, 300736 Timis Romania.
authors.forename: Marius
authors.initials: M
authors.lastname: Papurica
authors.affiliation: Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Str. Eftimie Murgu Nr. 2, Timisoara, 300041 Timis Romania.
authors.forename: Emil Robert
authors.initials: ER
authors.lastname: Stoicescu
authors.affiliation: Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Str. Eftimie Murgu Nr. 2, Timisoara, 300041 Timis Romania.
authors.forename: Sonia Elena
authors.initials: SE
authors.lastname: Popovici
authors.affiliation: Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, Str. Eftimie Murgu Nr. 2, Timisoara, 300041 Timis Romania.
authors.forename: Lavinia Melania
authors.initials: LM
authors.lastname: Bratu
authors.affiliation: Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Str. Eftimie Murgu Nr. 2, Timisoara, 300041 Timis Romania.
authors.forename: Corina
authors.initials: C
authors.lastname: Vernic
authors.affiliation: Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Str. Eftimie Murgu Nr. 2, Timisoara, 300041 Timis Romania.
authors.forename: Adriana Mariana
authors.initials: AM
authors.lastname: Sas
authors.affiliation: Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, Str. Eftimie Murgu Nr. 2, Timisoara, 300041 Timis Romania.
authors.forename: Adrian Tudor
authors.initials: AT
authors.lastname: Stan
authors.affiliation: Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Str. Eftimie Murgu Nr. 2, Timisoara, 300041 Timis Romania.|Clinic of Anaesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Bd. Liviu Rebreanu Nr.156, Timisoara, 300736 Timis Romania.
authors.forename: Ovidiu Horea
authors.initials: OH
authors.lastname: Bedreag
keywords: Critically ill; Energy expenditure; Indirect calorimetry; Metabolic disaster; Overfeeding; Oxidative stress; Polytrauma; Underfeeding