title: Activities, function, and health-related quality of life (HRQOL) of older adults with cancer.
abstract: OBJECTIVE
  This study aims to (1) describe the activities, function, and health-related quality of life (HRQOL) of a large sample of older adults (age ≥65) with cancer, (2) identify the associations with demographics, cancer type, comorbid conditions, and ability to participate in activities and functional status.
  
  
  METHODS
  The Health Registry/Cancer Survivorship Cohort is an institutional database designed to aid cancer survivorship research. The registry includes three measures of patient-reported HRQOL: FACT-G and PROMIS® Global measures for physical and mental health. Other measures included in the registry are cancer type, date from diagnosis, number of comorbid conditions and specific conditions and their limitations in daily activity, and self-reported daily activity/function.
  
  
  RESULTS
  Our sample consists of 768 older adults with cancer, mean age 72years, 60% female, and 90% White. Mean scores for HRQOL: FACT-G (85, range: 25-108), PROMIS-physical (48, range: 16-67) and, PROMIS-mental (51, range: 21-67). In multivariable models, Black race, one or more comorbid conditions, and Gastrointestinal cancer (p<.05), and patient- reported decreased levels of activities/function were all independently associated with poor HRQOL (p<.0001).
  
  
  CONCLUSIONS
  Older Black adults with cancer, those that have high comorbidity burden, with gastrointestinal cancers and those that report decreased ability to participate in daily activities/function reported poorer HRQOL. As geriatric oncology moves towards trying to identify who may need supportive services, this study demonstrated that a one question patient-reported level of activities and functional ability were independently associated with physical, mental, and cancer-specific HRQOL.
authors.affiliation: Department of Occupational Therapy, College of Health and Human Services, Colorado State University, 800 Oval Drive, Fort Collins, CO 80526, USA. Electronic address: m.pergolotti@colostate.edu.
authors.forename: Mackenzi
authors.initials: M
authors.lastname: Pergolotti
authors.affiliation: Biostatistics Core Facility, The University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, 170 Manning Drive, Chapel Hill, NC 27599, USA. Electronic address: Allison_Deal@med.unc.edu.
authors.forename: Allison M
authors.initials: AM
authors.lastname: Deal
authors.affiliation: Division of Hematology/Oncology, 'School of Medicine, University of Alabama at Birmingham, USA. Electronic address: gwilla@uab.edu.
authors.forename: Grant R
authors.initials: GR
authors.lastname: Williams
authors.affiliation: School of Nursing, The University of North Carolina at Chapel Hill, Carrington Hall, CB #7460, Chapel Hill, NC 27599-7460, USA. Electronic address: ashley_bryant@unc.edu.
authors.forename: Ashley L
authors.initials: AL
authors.lastname: Bryant
authors.affiliation: UNC Lineberger Comprehensive Cancer Center, Campus Box 7295, Chapel Hill 27599, USA. Electronic address: jeannette_bensen@med.unc.edu.
authors.forename: Jeannette T
authors.initials: JT
authors.lastname: Bensen
authors.affiliation: Geriatric Oncology Program, The University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, 170 Manning Drive, Chapel Hill, NC 27599, USA. Electronic address: hyman_muss@med.unc.edu.
authors.forename: Hyman B
authors.initials: HB
authors.lastname: Muss
authors.affiliation: Department of Health Policy and Management, 1101D McGavran-Greenberg Hall, Campus Box 7411, The University of North Carolina at Chapel Hill, Gillings School of Global Public Health, 135 Dauer Drive, Chapel Hill, NC 27599, USA. Electronic address: bbreeve@email.unc.edu.
authors.forename: Bryce B
authors.initials: BB
authors.lastname: Reeve
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D044383:Black People; D015897:Comorbidity; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000523:psychology*; D000071066:Patient Reported Outcome Measures; D011788:Quality of Life; D012042:Registries; D000073859:Survivorship; D044465:White People
keywords: Activities; Functional status; Health-related quality of life; Neoplasm; Older adults; Supportive services