title: Impact of oocyte donation on perinatal outcome in twin pregnancies.
abstract: OBJECTIVE
  To compare perinatal outcomes of twin pregnancies after oocyte donation (OD), in vitro fertilization (IVF) with autologous oocyte (AO), and non-IVF conception.
  
  
  METHODS
  Five-year retrospective cohort study.
  
  
  METHODS
  Tertiary university medical center.
  
  
  METHODS
  All patients with twin pregnancies who gave birth after 24 weeks of gestation. The outcomes of 102 OD twin pregnancies were compared with those of 201 AO and 369 non-IVF twin pregnancies.
  
  
  METHODS
  None.
  
  
  METHODS
  Obstetrical complications (pregnancy-induced hypertensive disorders, gestational diabetes, cholestasis, preterm rupture of membranes, mode of delivery, and postpartum hemorrhage) and neonatal outcome (preterm birth, low birth weight, neonatal hospitalization, and perinatal mortality).
  
  
  RESULTS
  There was an increased incidence of preeclampsia (OD 26.5%, AO 7.0%, non-IVF 8.7%) and postpartum hemorrhage (OD 23.5%, AO 12.4%, non-IVF 7.6%) in the OD group compared with the AO and non-IVF groups. After adjustment for confounding factors, including maternal age and chorionicity, the risk of preeclampsia remained higher in the OD group, as did the risk of postpartum hemorrhage. The OD group was not at higher risk than the AO and non-IVF groups for other complications, particularly for preterm birth or low birth weight.
  
  
  CONCLUSIONS
  OD twin pregnancies are associated with a higher risk of preeclampsia and postpartum hemorrhage than AO and non-IVF twin pregnancies.
authors.affiliation: Maternité Port Royal, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France; DHU Risques et Grossesse, Paris, France. Electronic address: lucie.guilbaud@gmail.com.
authors.forename: Lucie
authors.initials: L
authors.lastname: Guilbaud
authors.affiliation: Département de Gynécologie et de Médecine de la Reproduction, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France.
authors.forename: Pietro
authors.initials: P
authors.lastname: Santulli
authors.affiliation: Maternité Port Royal, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France; DHU Risques et Grossesse, Paris, France.
authors.forename: Eva
authors.initials: E
authors.lastname: Studer
authors.affiliation: Département de Gynécologie et de Médecine de la Reproduction, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gayet
authors.affiliation: Maternité Port Royal, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France; DHU Risques et Grossesse, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Goffinet
authors.affiliation: Maternité Port Royal, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France; DHU Risques et Grossesse, Paris, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Le Ray
mesh_terms: D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D004624:Embryo Transfer / Q000009:adverse effects; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro / Q000009:adverse effects; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D008875:Middle Aged; D018587:Oocyte Donation / Q000009:adverse effects*; D054238:Perinatal Mortality; D006473:Postpartum Hemorrhage / Q000209:etiology*; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D059285:Pregnancy, Twin; D047928:Premature Birth / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: Oocyte donation; assisted reproduction technology; postpartum hemorrhage; preeclampsia; twin gestation