title: Hepatitis C virus - Associated marginal zone lymphoma.
abstract: The link between hepatitis C virus (HCV) infection and the development of B-cell non-Hodgkin lymphoma is now well established and based on a number of epidemiological studies. It is further supported by the observation of lymphoma regression after HCV eradication by antiviral treatment. The far most frequent entities are marginal zone lymphoma (MZL) and diffuse large B-cell lymphoma (DLBCL). MZL usually emerge on a background of mixed cryoglobulinemia, a low-grade lymphoproliferation, and often transform into DLBCL, thereby following a multistep oncogenesis process. The role of HCV in lymphomagenesis is not yet fully understood but several mechanisms have been proposed including (i) chronic external stimulation through the B-cell receptor and other surface receptors, and (ii) direct transformation by intracellular viral proteins, the former being probably predominant in MZL. Regression of HCV-associated MZL can be achieved with antiviral therapy and the novel generation of direct-acting antiviral agents appears highly effective and safe for the treatment of these lymphoma.
authors.affiliation: Department of Hematology, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France; UPMC Univ Paris 06, UMRS-1138, Paris, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Armand
authors.affiliation: Hemato-Oncology Unit, Centre Hospitalier de Versailles, Le Chesnay, France; Université Versailles Saint Quentin en Yvelines, Université Paris-Saclay, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Besson
authors.affiliation: Department of Hematology, Hôpital Necker, APHP, Paris, France; Inserm UMR1163, CNRS ERL 8254, Institut Imagine, Paris, France; Université Sorbonne Paris Cité, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
authors.affiliation: Department of Hematology, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France; UPMC Univ Paris 06, UMRS-1138, Paris, France. Electronic address: frederic.davi@aphp.fr.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Davi
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy / Q000276:immunology* / Q000821:virology*
chemical_list: D000998:Antiviral Agents
keywords: Hepatitis C virus; Lymphomagenesis; Marginal zone lymphoma; Treatment