title: Hypothesis testing in functional linear models.
abstract: Functional data arise frequently in biomedical studies, where it is often of interest to investigate the association between functional predictors and a scalar response variable. While functional linear models (FLM) are widely used to address these questions, hypothesis testing for the functional association in the FLM framework remains challenging. A popular approach to testing the functional effects is through dimension reduction by functional principal component (PC) analysis. However, its power performance depends on the choice of the number of PCs, and is not systematically studied. In this article, we first investigate the power performance of the Wald-type test with varying thresholds in selecting the number of PCs for the functional covariates, and show that the power is sensitive to the choice of thresholds. To circumvent the issue, we propose a new method of ordering and selecting principal components to construct test statistics. The proposed method takes into account both the association with the response and the variation along each eigenfunction. We establish its theoretical properties and assess the finite sample properties through simulations. Our simulation results show that the proposed test is more robust against the choice of threshold while being as powerful as, and often more powerful than, the existing method. We then apply the proposed method to the cerebral white matter tracts data obtained from a diffusion tensor imaging tractography study.
authors.affiliation: Biostatistics, Division of Public Health Sciences Fred Hutchinson Cancer Research Center, Seattle, Washington, U.S.A.
authors.forename: Yu-Ru
authors.initials: YR
authors.lastname: Su
authors.affiliation: Biostatistics, Division of Public Health Sciences Fred Hutchinson Cancer Research Center, Seattle, Washington, U.S.A.
authors.forename: Chong-Zhi
authors.initials: CZ
authors.lastname: Di
authors.affiliation: Biostatistics, Division of Public Health Sciences Fred Hutchinson Cancer Research Center, Seattle, Washington, U.S.A.
authors.forename: Li
authors.initials: L
authors.lastname: Hsu
mesh_terms: D056324:Diffusion Tensor Imaging; D016014:Linear Models; D025341:Principal Component Analysis
keywords: Association-variation index; Functional association; Functional principal component analysis; Power; Wald-type tests