title: Clinical characteristics of anti-SAE antibodies in Chinese patients with dermatomyositis in comparison with different patient cohorts.
abstract: This study aimed to analyze the clinical features of anti-SAE antibodies in Chinese myositis patients in comparison with different cohorts. The anti-SAE antibodies were tested in myositis patients and in control subjects. Long-term follow-up was conducted on the antibody-positive patients. Anti-SAE antibodies were exclusively present in 12 out of 394 (3.0%) adult dermatomyositis (DM) patients. Of the anti-SAE-positive DM patients, 75% had distinctive diffuse dark-red or pigment-like skin rashes, and 67% of these patients experienced mild muscle weakness. Muscular biopsies showed mild pathological manifestations. Compared with the antibody-negative group, the average age of dermatomyositis onset in the antibody-positive group was higher, and dysphagia occurred more frequently noted (p = 0.012). Only 9 patients received follow-up, 7 experienced improvement after treatment. The anti-SAE antibody levels correlated with improved disease condition. The anti-SAE antibody was found exclusively in adult DM patients, occurring infrequently in Chinese patients. In addition to a diffuse dark-red or pigment-like skin rash and mild muscular weakness, common symptoms included propensity for developing dysphagia. Serum levels of the anti-SAE antibody correlated with myositis disease activity, and anti-SAE-positive patients were responsive to treatment.
authors.affiliation: Department of Rheumatology, China-Japan Friendship Hospital, Haoyang District, Beijing, China.
authors.forename: Yongpeng
authors.initials: Y
authors.lastname: Ge
authors.affiliation: Department of Rheumatology, China-Japan Friendship Hospital, Haoyang District, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Rheumatology, China-Japan Friendship Hospital, Haoyang District, Beijing, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Shu
authors.affiliation: Department of Rheumatology, China-Japan Friendship Hospital, Haoyang District, Beijing, China.
authors.forename: Qinglin
authors.initials: Q
authors.lastname: Peng
authors.affiliation: Department of Rheumatology, China-Japan Friendship Hospital, Haoyang District, Beijing, China. guochunwang@hotmail.com.
authors.forename: Guochun
authors.initials: G
authors.lastname: Wang
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000378:metabolism*; D016022:Case-Control Studies; D002681:China; D003680:Deglutition Disorders / Q000453:epidemiology / Q000209:etiology; D003882:Dermatomyositis / Q000150:complications* / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000453:epidemiology / Q000209:etiology; D044764:Ubiquitin-Activating Enzymes / Q000037:antagonists & inhibitors*
chemical_list: D001323:Autoantibodies; D044764:Ubiquitin-Activating Enzymes