title: Retinal, NPY- and 5ht- inputs to the aged suprachiasmatic nucleus in common marmosets (Callithrix jacchus).
abstract: The circadian timing system (CTS) anticipates optimal physiological patterns in response to environmental fluctuations, such as light-dark cycle. Since age-related disruption of circadian synchronization is linked to several pathological conditions, we characterized alterations of neurochemical constituents and retinal projections to the major pacemaker of CTS, the suprachiasmatic nucleus (SCN), in adult and aged marmosets. We used intraocular injections of neural tracer Cholera toxin b (CTb) to report age-related reductions in CTb, neuropeptide Y and serotonin immunoreactivities. Considering these projections arise in SCN from nuclei that relay environmental information to entrain the circadian clock, we provide important anatomical correlates to age-associated physiological deficits.
authors.affiliation: Laboratory of Neurochemical Studies, Physiology Department, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970 Natal, RN, Brazil. Electronic address: rovenaclara@gmail.com.
authors.forename: Rovena C G J
authors.initials: RCGJ
authors.lastname: Engelberth
authors.affiliation: Laboratory of Neurochemical Studies, Physiology Department, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970 Natal, RN, Brazil.
authors.forename: Kayo D de Azevedo
authors.initials: KDA
authors.lastname: Silva
authors.affiliation: Laboratory of Neurochemical Studies, Physiology Department, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970 Natal, RN, Brazil.
authors.forename: Felipe Porto
authors.initials: FP
authors.lastname: Fiuza
authors.affiliation: Laboratory of Neuroanatomy, Morphology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Joacil Germano
authors.initials: JG
authors.lastname: Soares
authors.affiliation: Laboratory of Neuroanatomy, Morphology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Miriam S M O
authors.initials: MSMO
authors.lastname: Costa
authors.affiliation: Laboratory of Neuroanatomy, Morphology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Ruthnaldo R de Melo
authors.initials: RRM
authors.lastname: Lima
authors.affiliation: Laboratory of Neuroanatomy, Morphology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Expedito Silva do
authors.initials: ESD
authors.lastname: Nascimento
authors.affiliation: Department of Biosciences, Federal University of Sergipe, Itabaiana, Sergipe, Brazil.
authors.forename: José R Dos
authors.initials: JRD
authors.lastname: Santos
authors.affiliation: Laboratory of Experimental Neurology, Department of Biomedical Sciences, Health Science Center, University of State of Rio Grande do Norte, Mossoró, RN, Brazil.
authors.forename: José R L P
authors.initials: JRLP
authors.lastname: Cavalcanti
authors.affiliation: Laboratory of Neurochemical Studies, Physiology Department, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970 Natal, RN, Brazil.
authors.forename: Jeferson S
authors.initials: JS
authors.lastname: Cavalcante
mesh_terms: D000344:Afferent Pathways / Q000502:physiology*; D000375:Aging; D000818:Animals; D002144:Callithrix; D002772:Cholera Toxin / Q000378:metabolism; D003720:Densitometry; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D012160:Retina / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013493:Suprachiasmatic Nucleus / Q000166:cytology / Q000378:metabolism*
chemical_list: D009478:Neuropeptide Y; D012701:Serotonin; D002772:Cholera Toxin
keywords: Aging; Cholera toxin subunit b; Neuropeptide Y; Retinal projections; Serotonin; Suprachiasmatic nucleus