title: Donor Considerations in Fecal Microbiota Transplantation.
abstract: OBJECTIVE
  Tremendous acceleration has been made in understanding the gut microbiota in the past decade and, with it, further understanding of the pathologic role of dysbiosis and the use of fecal microbiota transplantation (FMT) as therapy. FMT has been studied in many disease states including the most common indication of Clostridium difficile infection (CDI), though many questions regarding stool donor selection remain.
  
  
  RESULTS
  Though traditionally, one donor has provided stool for one patient, research is underway to explore many donor selection considerations from the use of pooled donor stool to selection of a high diversity donor. It is well-known that dietary intake shapes the gut microbiota and the potential implications of this on FMT donor selection are being explored. Though further high-quality research is needed, optimizing the fecal microbiota inoculum holds great promise.
authors.affiliation: Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Naval Medical Center San Diego, San Diego, CA, USA. danimhbarnes@gmail.com.
authors.forename: Danielle
authors.initials: D
authors.lastname: Barnes
authors.affiliation: Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Stanford Children's Health, Palo Alto, CA, USA.
authors.forename: K T
authors.initials: KT
authors.lastname: Park
mesh_terms: D046148:Donor Selection / Q000379:methods* / Q000639:trends; D064806:Dysbiosis / Q000628:therapy; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology / Q000628:therapy; D000069467:Fecal Microbiota Transplantation / Q000379:methods* / Q000639:trends; D000069196:Gastrointestinal Microbiome; D006801:Humans; D016032:Randomized Controlled Trials as Topic
keywords: Clostridium difficile infection; Competitive donor; FMT donor; Fecal microbiota transplant