title: Mushroom Consumption and Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study.
abstract: BACKGROUND
  Both in vivo and in vitro studies have indicated that edible mushrooms may have preventive effects against cognitive impairment. However, few cohort studies have yet examined the relationship between mushroom consumption and incident dementia.
  
  
  OBJECTIVE
  We examined the relationship between mushroom consumption and incident dementia in a population of elderly Japanese subjects.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Ohsaki Cohort 2006 Study.
  
  
  METHODS
  13,230 individuals aged ≥65 years living in Ohsaki City, northeastern Japan.
  
  
  METHODS
  Daily mushroom consumption, other lifestyle factors, and dementia incidence.
  
  
  RESULTS
  The 5.7 years incidence of dementia was 8.7%. In comparison with participants who consumed mushrooms <1 time/wk, the multi-adjusted HRs (95% CI) for incident dementia among those did so 1-2 times/week and ≥3 times/week were 0.95 (0.81, 1.10) and 0.81 (0.69, 0.95), respectively (P-trend <.01). The inverse association persisted after excluding participants whose dementia event occurred in the first 2 years of follow-up and whose baseline cognitive function was lower. The inverse association did not differ statistically in terms of vegetable consumption (P-interaction = .10).
  
  
  CONCLUSIONS
  This cohort study suggests that frequent mushroom consumption is significantly associated with a lower risk of incident dementia, even after adjustment for possible confounding factors.
authors.affiliation: Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.
authors.forename: Shu
authors.identifier: http://orcid.org/0000-0002-1208-5836
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.
authors.forename: Yasutake
authors.initials: Y
authors.lastname: Tomata
authors.affiliation: Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.
authors.forename: Kemmyo
authors.initials: K
authors.lastname: Sugiyama
authors.affiliation: Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Sugawara
authors.affiliation: Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsuji
mesh_terms: D000363:Agaricales; D000368:Aged; D003071:Cognition; D003704:Dementia / Q000453:epidemiology* / Q000209:etiology; D004034:Diet Surveys; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires
keywords: Japan; cohort study; dementia; elderly; mushroom