title: Visible-Light-Promoted Tandem Difluoroalkylation-Amidation: Access to Difluorooxindoles from Free Anilines.
abstract: An efficient and synthetically convenient method for the synthesis of 3,3-difluoro-2-oxindole through a visible-light-induced photoredox difluoromethylation-amidation is described. The process can generate a broad range of difluorooxindoles using bromodifluoroacetate and broadly available free anilines. The wide range of substrate tolerance and mild reaction conditions make this transformation a highly valuable method in applications for drug discovery and development.
authors.affiliation: School of Energy Science and Engineering, University of Electronic Science and Technology of China , 2006 Xiyuan Avenue, West High-Tech Zone, Chengdu, Sichuan 611731, China.
authors.forename: Ling-Chao
authors.initials: LC
authors.lastname: Yu
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Ji-Wei
authors.initials: JW
authors.lastname: Gu
authors.affiliation: School of Energy Science and Engineering, University of Electronic Science and Technology of China , 2006 Xiyuan Avenue, West High-Tech Zone, Chengdu, Sichuan 611731, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Xingang
authors.identifier: 0000-0002-4406-6533
authors.initials: X
authors.lastname: Zhang