title: [Sleep-disordered breathing syndrome in acute ischemic stroke].
abstract: OBJECTIVE
  To evaluate the prevalence, structure and risk factors of sleep-disordered breathing in patients with acute ischemic stroke.
  
  
  METHODS
  This prospective study included 54 acute ischemic stroke patients aged 66 [57; 72] years, 32 men, 22 women. The diagnosis was confirmed by MRI. The neurological state was assessed with the NIHSS and modified Rankin Scale (mRS). To verify the SDB, cardiorespiratory monitoring was performed on 2-5 day from stroke onset. Total number of SDB episodes, apnea/hypopnea index (AHI), the index of hypoxemia (IH) were registered.
  
  
  CONCLUSIONS
  SDB was detected in 50 (92%) patients, including 44 (88%) with predominantly obstructive apneas (OA), 6 (12%) patients with central apnea (CA). It was found that the severity of respiratory disorders did not depend on the severity of the neurological state but is associated with a variety of somatic, hemodynamic and metabolic disorders (increased BMI, smoking, diabetes mellitus,atrial fibrillation - AF). Cardioembolic stroke (СES) was accompanied by a more pronounced SDB and can be considered as a marker of respiratory disorders during sleep, especially in patients with AF. Involvement of the insula in the brain infarct zone is a significant factor in the development of SDB and increase of central apnea (CA). Multiple small deep (lacunar) infarcts of the brain, including asymptomatic infarcts, visualized by MRI also indicate a high risk of obstructive SDB.
authors.affiliation: Research Center of Neurology, Moscow, Russia.
authors.forename: G M
authors.initials: GM
authors.lastname: Lutohin
authors.affiliation: Research Center of Neurology, Moscow, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Geraskina
authors.affiliation: Research Center of Neurology, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Fonyakin
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000150:complications; D015992:Body Mass Index; D002545:Brain Ischemia / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012890:Sleep; D012891:Sleep Apnea Syndromes; D020181:Sleep Apnea, Obstructive / Q000150:complications*; D020521:Stroke / Q000150:complications*