title: Soybean polar lipids differently impact adipose tissue inflammation and the endotoxin transporters LBP and sCD14 in flaxseed vs. palm oil-rich diets.
abstract: Obesity and type 2 diabetes are nutritional pathologies, characterized by a subclinical inflammatory state. Endotoxins are now well recognized as an important factor implicated in the onset and maintain of this inflammatory state during fat digestion in high-fat diet. As a preventive strategy, lipid formulation could be optimized to limit these phenomena, notably regarding fatty acid profile and PL emulsifier content. Little is known about soybean polar lipid (SPL) consumption associated to oils rich in saturated FA vs. anti-inflammatory omega-3 FA such as α-linolenic acid on inflammation and metabolic endotoxemia. We then investigated in mice the effect of different synthetic diets enriched with two different oils, palm oil or flaxseed oil and containing or devoid of SPL on adipose tissue inflammation and endotoxin receptors. In both groups containing SPL, adipose tissue (WAT) increased compared with groups devoid of SPL and an induction of MCP-1 and LBP was observed in WAT. However, only the high-fat diet in which flaxseed oil was associated with SPL resulted in both higher WAT inflammation and higher circulating sCD14 in plasma. In conclusion, we have demonstrated that LPS transporters LBP and sCD14 and adipose tissue inflammation can be modulated by SPL in high fat diets differing in oil composition. Notably high-flaxseed oil diet exerts a beneficial metabolic impact, however blunted by PL addition. Our study suggests that nutritional strategies can be envisaged by optimizing dietary lipid sources in manufactured products, including fats/oils and polar lipid emulsifiers, in order to limit the inflammatory impact of palatable foods.
authors.affiliation: Univ-Lyon, CarMeN laboratory, INRA UMR1397, INSERM U1060, Université Claude Bernard Lyon 1, INSA-Lyon, IMBL, F-69621 Villeurbanne, France.
authors.forename: Manon
authors.initials: M
authors.lastname: Lecomte
authors.affiliation: ITERG-ENMS, Université de Bordeaux, rue Léo Saignat, 33076 Bordeaux cedex, France.
authors.forename: Leslie
authors.initials: L
authors.lastname: Couëdelo
authors.affiliation: INRA UMR1397, CarMeN laboratory, Univ-Lyon, INSERM U1060, Université Claude Bernard Lyon 1, F-69921 Oullins, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Meugnier
authors.affiliation: INRA UMR1397, CarMeN laboratory, Univ-Lyon, INSERM U1060, Université Claude Bernard Lyon 1, F-69921 Oullins, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Loizon
authors.affiliation: Univ-Lyon, CarMeN laboratory, INRA UMR1397, INSERM U1060, Université Claude Bernard Lyon 1, INSA-Lyon, IMBL, F-69621 Villeurbanne, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Plaisancié
authors.affiliation: Univ-Lyon, CarMeN laboratory, INRA UMR1397, INSERM U1060, Université Claude Bernard Lyon 1, INSA-Lyon, IMBL, F-69621 Villeurbanne, France.
authors.forename: Annie
authors.initials: A
authors.lastname: Durand
authors.affiliation: Univ-Lyon, CarMeN laboratory, INRA UMR1397, INSERM U1060, Université Claude Bernard Lyon 1, INSA-Lyon, IMBL, F-69621 Villeurbanne, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Géloën
authors.affiliation: ITERG-ENMS, Université de Bordeaux, rue Léo Saignat, 33076 Bordeaux cedex, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Joffre
authors.affiliation: ITERG-ENMS, Université de Bordeaux, rue Léo Saignat, 33076 Bordeaux cedex, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Vaysse
authors.affiliation: Univ-Lyon, CarMeN laboratory, INRA UMR1397, INSERM U1060, Université Claude Bernard Lyon 1, INSA-Lyon, IMBL, F-69621 Villeurbanne, France.
authors.forename: Marie-Caroline
authors.initials: MC
authors.lastname: Michalski
authors.affiliation: Univ-Lyon, CarMeN laboratory, INRA UMR1397, INSERM U1060, Université Claude Bernard Lyon 1, INSA-Lyon, IMBL, F-69621 Villeurbanne, France. Electronic address: fabienne.laugerette@univ-lyon1.fr.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Laugerette
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D059305:Diet, High-Fat; D019587:Dietary Supplements; D005227:Fatty Acids / Q000032:analysis; D008043:Linseed Oil / Q000494:pharmacology*; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008810:Mice, Inbred C57BL; D000073878:Palm Oil / Q000494:pharmacology*; D015434:Panniculitis / Q000209:etiology*; D013025:Glycine max / Q000737:chemistry*; D000099231:Lipopolysaccharide-Binding Protein
chemical_list: D000209:Acute-Phase Proteins; D002352:Carrier Proteins; D005227:Fatty Acids; D008043:Linseed Oil; D018950:Lipopolysaccharide Receptors; D008562:Membrane Glycoproteins; D000073878:Palm Oil; D000099231:Lipopolysaccharide-Binding Protein
keywords: CD14; Endotoxin; Flaxseed; Inflammation; LBP; Lecithin