title: Epigenetics of kidney disease.
abstract: DNA methylation and histone modifications determine renal programming and the development and progression of renal disease. The identification of the way in which the renal cell epigenome is altered by environmental modifiers driving the onset and progression of renal diseases has extended our understanding of the pathophysiology of kidney disease progression. In this review, we focus on current knowledge concerning the implications of epigenetic modifications during renal disease from early development to chronic kidney disease progression including renal fibrosis, diabetic nephropathy and the translational potential of identifying new biomarkers and treatments for the prevention and therapy of chronic kidney disease and end-stage kidney disease.
authors.affiliation: Department of Medicine IV, Faculty of Medicine, University of Freiburg, Freiburg, Germany. nicola.wanner@uniklinik-freiburg.de.|Center for Systems Biology (ZBSA), Albert-Ludwigs-University, Freiburg, Germany. nicola.wanner@uniklinik-freiburg.de.|Renal Division, University Hospital Freiburg, Breisacher Strasse 66, 79106, Freiburg, Germany. nicola.wanner@uniklinik-freiburg.de.
authors.forename: Nicola
authors.identifier: 0000-0002-4886-7020
authors.initials: N
authors.lastname: Wanner
authors.affiliation: Department of Medicine IV, Faculty of Medicine, University of Freiburg, Freiburg, Germany. wibke.bechtel@uniklinik-freiburg.de.|Renal Division, University Hospital Freiburg, Breisacher Strasse 66, 79106, Freiburg, Germany. wibke.bechtel@uniklinik-freiburg.de.
authors.forename: Wibke
authors.initials: W
authors.lastname: Bechtel-Walz
mesh_terms: D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005355:Fibrosis; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000473:pathology; D051436:Renal Insufficiency, Chronic / Q000378:metabolism* / Q000473:pathology
keywords: Chronic kidney disease; Diabetes; Epigenetic therapy; Epigenetics; Kidney