title: Application of Metabolic Profiling to Abdominal Aortic Aneurysm Research.
abstract: Abdominal aortic aneurysm (AAA) is a complex disease posing diagnostic and therapeutic challenges. Metabonomics may aid in the diagnosis of AAA, determination of individualized risk, discovery of therapeutic targets, and improve understanding of pathogenesis. A systematic review of the diversity and outcomes of existing AAA metabonomic research has been performed. Original research studies applying metabonomics to human aneurysmal disease are included. Seven relevant articles were identified: four studies were based on plasma/serum metabolite profiling, and three studies examined aneurysmal tissue. Aminomalonic acid, guanidinosuccinic acid, and glycerol emerge as potential plasma biomarkers of large aneurysm. Lipid profiling improves predictive models of aneurysm presence. Patterns of metabolite variation associated with AAA relate to carbohydrate and lipid metabolism. Perioperative perturbations in metabolites suggest differential systemic inflammatory responses to surgery, generating hypotheses for adjunctive perioperative therapy. Significant limitations include small study sizes, lack of correction for multiple testing false discovery rates, and single time-point sampling. Metabolic profiling carries the potential to identify biomarkers of AAA and elucidate pathways underlying aneurysmal disease. Statistically and methodologically robust studies are required for validation, addressing the hiatus in understanding mechanisms of aneurysm growth and developing effective treatment strategies.
authors.affiliation: Section of Vascular Surgery, Imperial College London , 4 North, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom.
authors.forename: Mahim I
authors.identifier: 0000-0002-9256-684X
authors.initials: MI
authors.lastname: Qureshi
authors.affiliation: Section of Vascular Surgery, Imperial College London , 4 North, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom.
authors.forename: Michele
authors.initials: M
authors.lastname: Greco
authors.affiliation: Computational & Systems Medicine, Imperial College London , Sixth Floor, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, United Kingdom.
authors.forename: Panagiotis A
authors.initials: PA
authors.lastname: Vorkas
authors.affiliation: Computational & Systems Medicine, Imperial College London , Sixth Floor, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, United Kingdom.
authors.forename: Elaine
authors.identifier: 0000-0002-0556-8389
authors.initials: E
authors.lastname: Holmes
authors.affiliation: Section of Vascular Surgery, Imperial College London , 4 North, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom.
authors.forename: Alun H
authors.initials: AH
authors.lastname: Davies
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D015415:Biomarkers / Q000378:metabolism; D018450:Disease Progression; D005990:Glycerol / Q000378:metabolism*; D006146:Guanidines / Q000378:metabolism*; D006801:Humans; D044045:Lipoxins / Q000378:metabolism; D008314:Malonates / Q000378:metabolism*; D055442:Metabolome; D055432:Metabolomics / Q000379:methods; D011379:Prognosis; D013386:Succinates / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism
chemical_list: D015415:Biomarkers; D006146:Guanidines; D044045:Lipoxins; D008314:Malonates; D013386:Succinates; C040527:lipoxin A4; C019249:aminomalonic acid; D013929:Thromboxane B2; C001318:guanidinosuccinic acid; D005990:Glycerol
keywords: aneurysm; arterial disease; metabolic profiling; metabolomics; metabonomics; systems biology