title: Multicomponent, Tumor-Homing Chitosan Nanoparticles for Cancer Imaging and Therapy.
abstract: Current clinical methods for cancer diagnosis and therapy have limitations, although survival periods are increasing as medical technologies develop. In most cancer cases, patient survival is closely related to cancer stage. Late-stage cancer after metastasis is very challenging to cure because current surgical removal of cancer is not precise enough and significantly affects bystander normal tissues. Moreover, the subsequent chemotherapy and radiation therapy affect not only malignant tumors, but also healthy tissues. Nanotechnologies for cancer treatment have the clear objective of solving these issues. Nanoparticles have been developed to more accurately differentiate early-stage malignant tumors and to treat only the tumors while dramatically minimizing side effects. In this review, we focus on recent chitosan-based nanoparticles developed with the goal of accurate cancer imaging and effective treatment. Regarding imaging applications, we review optical and magnetic resonance cancer imaging in particular. Regarding cancer treatments, we review various therapeutic methods that use chitosan-based nanoparticles, including chemo-, gene, photothermal, photodynamic and magnetic therapies.
authors.affiliation: Department of Biomedical Engineering, Yonsei University, 1 Yonseidae-gil, Wonju 26493, Gangwon-do, Korea. jkey@yonsei.ac.kr.
authors.forename: Jaehong
authors.initials: J
authors.lastname: Key
authors.affiliation: Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Gyeonggi-do, Korea. kspark1223@cau.ac.kr.
authors.forename: Kyeongsoon
authors.initials: K
authors.lastname: Park
mesh_terms: D000818:Animals; D048271:Chitosan / Q000737:chemistry; D003131:Combined Modality Therapy; D004337:Drug Carriers; D016503:Drug Delivery Systems; D055088:Early Detection of Cancer / Q000379:methods; D006801:Humans; D057054:Molecular Imaging / Q000379:methods; D064847:Multimodal Imaging / Q000379:methods; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*
chemical_list: D004337:Drug Carriers; D048271:Chitosan
keywords: chemotherapy; chitosan; drug delivery; gene therapy; hyperthermic therapy; magnetic resonance imaging; nanoparticles; optical imaging; photodynamic therapy; photothermal therapy