title: Association of Y-linked variants with impulsivity and aggression in boys with attention-deficit/hyperactivity disorder of Chinese Han descent.
abstract: Y chromosome plays important role in brain function and may help to explain the sex difference in attention-deficit/hyperactivity disorder (ADHD). A total of 857 boys with ADHD and 574 male controls were genotyped for 14 Y-linked markers. Analyses for both dichotomous phenotype and quantitative traits and the interaction effects with MAOA were performed. The results indicated significant association of four markers (M88, M95, M175, and M119) with inhibition function and aggression in boys with ADHD. Positive interaction effects with MAOA were also detected. In conclusion, some Y-linked variants may be associated with the impulsivity and aggression in boys with ADHD.
authors.affiliation: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors.forename: Haimei
authors.initials: H
authors.lastname: Li
authors.affiliation: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Su
authors.affiliation: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.affiliation: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.affiliation: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China. Electronic address: qianqiujin@bjmu.edu.cn.
authors.forename: Qiujin
authors.initials: Q
authors.lastname: Qian
authors.affiliation: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China. Electronic address: wangyf@bjmu.edu.cn.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000374:Aggression; D044466:Asian People / Q000235:genetics* / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D002648:Child; D002681:China; D050173:Genes, Y-Linked; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007175:Impulsive Behavior; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics; D010641:Phenotype
chemical_list: D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human
keywords: ADHD; Externalizing behavior; Y-linked variants