title: Cellular Midpalatal Suture Changes after Rapid Maxillary Expansion in Growing Subjects: A Case Report.
abstract: The present case report aimed to investigate immediate histologic changes in midpalatal suture in humans following rapid maxillary expansion compared to control. Three patients (mean age 8.3 +/- 0.9 years) were enrolled in the case report and underwent midpalatal suture biopsy. Two patients underwent treatment before biopsy. The third patient did not show transversal maxillary deficiency and was enrolled as a control. Biopsy samples of midpalatal suture at 7 (subject 1) and 30 days (subject 2) after maxillary expansion as well as of one control (subject 3) were collected and processed for histology. In the control (subject 3) inter-digitations at the palatal suture gap were observed. At 7 days (subject 1) mature bone with small marrow spaces and trabecular bone with the peculiar storiform appearance inside the soft tissue and collagen fibers running parallel only in the central part were present. At 30 days (subject 2), a greater number of newly-formed bone trabeculae with a perpendicular orientation to the long axis of the suture could be seen. At 30 days the fibrous component of bone tissue was less represented compared to the sample at 7 days. Data from the preliminary histological results showed that bone formation was observed in the gap after rapid maxillary expansion, although the healing process was still ongoing.
authors.affiliation: Department of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, Italy. alberto.caprioglio@uninsubria.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Caprioglio
authors.affiliation: Department of Medical, Surgical and Health Sciences, University of Messina, 98100 Messina, Italy. rosamariaf@hotmail.it.
authors.forename: Rosamaria
authors.initials: R
authors.lastname: Fastuca
authors.affiliation: Department of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, Italy. pieroantonio@gmail.com.
authors.forename: Piero Antonio
authors.initials: PA
authors.lastname: Zecca
authors.affiliation: Department of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, Italy. teoberet@libero.it.
authors.forename: Matteo
authors.initials: M
authors.lastname: Beretta
authors.affiliation: Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy. camangan@gmail.com.
authors.forename: Carlo
authors.initials: C
authors.lastname: Mangano
authors.affiliation: Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy. apiattelli@unich.it.
authors.forename: Adriano
authors.initials: A
authors.lastname: Piattelli
authors.affiliation: Department of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, Italy. aldo.macchi@uninsubria.it.
authors.forename: Aldo
authors.initials: A
authors.lastname: Macchi
authors.affiliation: Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy. gio.iezzi@unich.it.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Iezzi
mesh_terms: D001846:Bone Development; D002648:Child; D006801:Humans; D008297:Male; D008437:Maxilla / Q000473:pathology; D010155:Palatal Expansion Technique; D010159:Palate / Q000601:surgery*; D013537:Sutures; D013997:Time Factors
keywords: maxillary expansion; suture; treatment