title: [Association of I/D and -786 Polymorphisms of ACE and NOS3 Genes With Features of the Course of Ischemic Heart Disease and Diabetes Mellitus Type 2].
abstract: to study relationship of ACE insertion-deletion (I/D) polymorphism and NOS3 T-786C polymorphism with characteristics of the course of ischemic heart disease (IHD) at the background of diabetes mellitus.
  
  
  
  Were examined 114 patients with IHD, 29.8% of patients had type 2 diabetes mellitus. ACE and NOS3 polymorphisms were determined by allele-specific polymerase chain reaction with primers by "Lytech".
  
  
  
  Patients with combined pathology belonged to older age group, had increased frequency of obesity and predominance of functional class II chronic heart failure. In this group we detected association of D allele of the ACE gene with higher frequency of dyslipidemia and obesity. Among patients with IHD without diabetes we observed associations of ACE I/D and NOS3 T-786C polymorphisms (close and moderate, respectively) with severity of effort angina. We also found that frequency of dyslipidemia among carriers of II and TT genotypes was lower than among carriers of other genotypes.
  
  
  
  Presence of type 2 diabetes as background pathology leads to a change of character of association of ACE I/D and NOS3 T-786C polymorphisms with clinical characteristics of patients with IHD.
authors.affiliation: Research Institute for Cardiology, Tomsk, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Afanasiev
authors.affiliation: Research Institute for Cardiology, Tomsk, Russia.
authors.forename: E F
authors.initials: EF
authors.lastname: Muslimova
authors.affiliation: Research Institute for Cardiology, Tomsk, Russia.
authors.forename: T Y
authors.initials: TY
authors.lastname: Rebrov
authors.affiliation: Research Institute for Cardiology, Tomsk, Russia.
authors.forename: T N
authors.initials: TN
authors.lastname: Sergienko
authors.affiliation: Research Institute for Cardiology, Tomsk, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Repin
mesh_terms: D000368:Aged; D000483:Alleles; D003324:Coronary Artery Disease / Q000150:complications* / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications* / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; D007703:Peptidyl-Dipeptidase A
keywords: ACE; NOS3; ischemic heart disease; type 2 diabetes mellitus