title: Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders.
abstract: The flavonoids, baicalin (5,6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one-7-O-d-β-glucuronic acid) 1 and its aglycone, baicalein 2 are found in edible medicinal plants, Scutellaria baicalensis Georgi and Oroxylum indicum (L.) Kurz in abundant quantities. The antioxidant and anti-inflammatory effects of these flavonoids have been demonstrated in various disease models, including diabetes, cardiovascular diseases, inflammatory bowel diseases, gout and rheumatoid arthritis, asthma, neurodegenerative-, liver- and kidney diseases, encephalomyelitis, and carcinogenesis. These flavonoids have almost no toxicity to human normal epithelial, peripheral and myeloid cells. Their antioxidant and anti-inflammatory activities are largely due to their abilities to scavenge the reactive oxygen species (ROS) and improvement of antioxidant status by attenuating the activity of NF-κB and suppressing the expression of several inflammatory cytokines and chemokines including monocyte chemotactic protein-1 (MCP-1), nitric oxide synthase, cyclooxygenases, lipoxygenases, cellular adhesion molecules, tumor necrosis factor and interleukins. In this review, we summarize the antioxidant and anti-inflammatory effects of baicalin and baicalein with molecular mechanisms for their chemopreventive and chemotherapeutic applications in the treatment of inflammatory-related diseases.
authors.affiliation: Department of Chemistry, Tripura University, Suryamaninagar 799022, Tripura, India. Electronic address: dindabtu@gmail.com.
authors.forename: Biswanath
authors.initials: B
authors.lastname: Dinda
authors.affiliation: Department of Chemistry, Dasaratha Deb Memorial College, Khowai 799201, Tripura, India.
authors.forename: Subhajit
authors.initials: S
authors.lastname: Dinda
authors.affiliation: Department of Chemistry, Dasaratha Deb Memorial College, Khowai 799201, Tripura, India.
authors.forename: Saikat
authors.initials: S
authors.lastname: DasSharma
authors.affiliation: Department of Chemistry, National Institute of Technology, Agartala 799055, Tripura, India.
authors.forename: Rajarshi
authors.initials: R
authors.lastname: Banik
authors.affiliation: Department of Chemistry, Tripura University, Suryamaninagar 799022, Tripura, India.
authors.forename: Ankita
authors.initials: A
authors.lastname: Chakraborty
authors.affiliation: Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, 1300 Jefferson Park Ave, VA22908, USA.
authors.forename: Manikarna
authors.initials: M
authors.lastname: Dinda
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000627:therapeutic use*; D044950:Flavanones / Q000737:chemistry / Q000627:therapeutic use*; D005419:Flavonoids / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D044950:Flavanones; D005419:Flavonoids; C038044:baicalin; C006680:baicalein
keywords: Baicalein; Baicalin; Chemoprevention; Flavonoids; Inflammatory diseases