title: Treatment of anticoagulated patients with negative pressure wound therapy.
abstract: There is a paucity of evidence surrounding the use of negative pressure wound therapy (NPWT) in patients receiving anticoagulant medication. Guidelines generally recommend caution regarding the use of NPWT in anticoagulated patients in general, but areas of particular risk are frequently not highlighted. The US Food and Drug Authority (FDA) reported six mortalities between 2009 and 2011 in patients receiving NPWT. These mortalities were associated with the use of NPWT over vascular graft sites. The coagulation status of these patients was not reported. It is the authors' recommendation that guidelines regarding the use of NPWT in anticoagulated patients highlight specific clinical situations of risk, although there is insufficient evidence to support the avoidance of NPWT in anticoagulated patients in general.
authors.affiliation: School of Nursing, Midwifery and Paramedicine, Curtin University, Bentley, WA, Australia.|Wound Management Innovation Cooperative Research Centre (WMI CRC).
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Boxall
authors.affiliation: School of Nursing, Midwifery and Paramedicine, Curtin University, Bentley, WA, Australia.|The Primary Health Care and Community Nursing at Curtin is part of the School of Nursing, Midwifery and Paramedicine Silver Chain Group, Bentley, WA, Australia.
authors.forename: Keryln
authors.initials: K
authors.lastname: Carville
authors.affiliation: School of Nursing, Midwifery and Paramedicine, Curtin University, Bentley, WA, Australia.
authors.forename: Gavin D
authors.initials: GD
authors.lastname: Leslie
authors.affiliation: Vascular and Endovascular Surgery, Sir Charles Gairdner Hospital, Perth, WA, Australia.|University of Western Australia, Crawley, WA, Australia.|Health Sciences Research and Graduate Studies, Curtin University, Bentley, WA.
authors.forename: Shirley J
authors.initials: SJ
authors.lastname: Jansen
mesh_terms: D000925:Anticoagulants; D006801:Humans; D054843:Negative-Pressure Wound Therapy / Q000009:adverse effects* / Q000592:standards*; D017410:Practice Guidelines as Topic; D014481:United States; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D000925:Anticoagulants
keywords: Anticoagulant; Negative pressure wound therapy; Topical negative pressure