title: Time and age dependent decrease of NT-proBNP after septal myectomy in hypertrophic obstructive cardiomyopathy.
abstract: NT-proBNP level is a predictive factor in hypertrophic cardiomyopathy patients, in which left ventricular outflow tract obstruction contributes to an increased NT-proBNP level. However, studies regarding the influence of septal myectomy on NT-proBNP level in hypertrophic obstructive cardiomyopathy are lacking.
  
  
  
  One hundred and eighty-two patients who underwent septal myectomy in Fuwai Hospital from May 2011 to March 2016 and were included in the present study. Preoperative and follow-up NT-proBNP was retrospectively collected. Correlation analysis was performed to determine the factors affecting preoperative NT-proBNP and postoperative decrease.
  
  
  
  The cohort had a median age of 46.2 [IQR: 36.5-53.1] years, and 106 (58.2%) patients were male. NT-proBNP decreased to 816.5 [IQR: 400.3-1661.8] pg/mL from preoperative 1732.4 [IQR: 819-3296.5] pg/mL (p<0.001). Baseline NT-proBNP was correlated with gender (p<0.001), maximum septal thickness (p<0.001), and resting pressure gradient (p=0.006). The extent of NT-proBNP decrease was positively correlated with age (p<0.001), baseline NT-proBNP (p<0.001), follow-up time (p=0.020), and enlargement of the ascending aorta (p=0.019). NT-proBNP exhibited a persistent decrease after myectomy.
  
  
  
  Myectomy significantly reduced NT-proBNP level in hypertrophic obstructive cardiomyopathy patients, in which a time-dependent manner of decrease indicated myocardial remodeling of the heart after myectomy.
authors.affiliation: .
authors.forename: Hao
authors.initials: H
authors.lastname: Cui
authors.affiliation: .
authors.forename: Xi
authors.initials: X
authors.lastname: Wu
authors.affiliation: .
authors.forename: Shuiyun
authors.initials: S
authors.lastname: Wang
authors.affiliation: .
authors.forename: Bing
authors.initials: B
authors.lastname: Tang
authors.affiliation: .
authors.forename: Changsheng
authors.initials: C
authors.lastname: Zhu
authors.affiliation: .
authors.forename: Haibo
authors.initials: H
authors.lastname: Chen
authors.affiliation: .
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhou
authors.affiliation: .
authors.forename: Rong
authors.initials: R
authors.lastname: Wu
authors.affiliation: .
authors.forename: Qinjun
authors.initials: Q
authors.lastname: Yu
authors.affiliation: .
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Huang
mesh_terms: D000328:Adult; D000367:Age Factors; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D004452:Echocardiography; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000032:analysis*; D010446:Peptide Fragments / Q000032:analysis*; D057234:Preoperative Period; D012189:Retrospective Studies
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: N-terminal pro-B-type natriuretic peptide (NT-proBNP); age; hypertrophic cardiomyopathy; myectomy; remodeling