title: Growth of giant intracranial aneurysms: An aneurysmal wall disorder?
abstract: The enlargement of giant intracranial aneurysms (IA) can be observed in 30 % of cases resulting in a neurological deficit and epilepsy due to its mass effect. This growth process could be due to a morphological disorder of the IA wall. The authors report on 2 cases of giant IA growth responsible for intracranial hypertension. The treatment of these giant IA required a microsurgical excision combined with a series of cerebral revascularization procedures. The role of vasa vasorum on the inflammatory granuloma outside the vessel, which induced the enlargement, is discussed. These cases illustrate the abluminal vasculopathy as the main involvement of this unfavourable natural history.
authors.affiliation: Department of Neurosurgery, Rouen University Hospital, 1, rue de Germont, 76031 Rouen cedex, France. Electronic address: francois-xavier.ferracci@neurochirurgie.fr.
authors.forename: F-X
authors.initials: FX
authors.lastname: Ferracci
authors.affiliation: Department of Neuroradiology, Rouen University Hospital, 76000 Rouen, France.
authors.forename: V
authors.initials: V
authors.lastname: Gilard
authors.affiliation: Department of Neurosurgery, Strasbourg University Hospital, 67000 Strasbourg, France.
authors.forename: H
authors.initials: H
authors.lastname: Cebula
authors.affiliation: Department of Neuroradiology, Rouen University Hospital, 76000 Rouen, France.
authors.forename: N
authors.initials: N
authors.lastname: Magne
authors.affiliation: Department of Neurosurgery, Lille University Hospital, 59000 Lille, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Lejeune
authors.affiliation: Department of Neurosurgery, Rouen University Hospital, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: O
authors.initials: O
authors.lastname: Langlois
authors.affiliation: Department of Neurosurgery, Strasbourg University Hospital, 67000 Strasbourg, France.
authors.forename: F
authors.initials: F
authors.lastname: Proust
mesh_terms: D002533:Cerebral Angiography / Q000379:methods; D002548:Cerebral Revascularization / Q000379:methods; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D008866:Microsurgery / Q000379:methods; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods; D016896:Treatment Outcome
keywords: Aneurysmal wall; Giant intracranial aneurysm; Vasa vasorum