title: Clival paragangliomas: a report of two cases involving the midline skull base and review of the literature.
abstract: Head and neck paragangliomas are rare neuroendocrine tumors that arise from paraganglion cells of the parasympathetic nervous system. Paragangliomas arising from the midline skull base have only rarely been reported. Surgery is the mainstay of treatment and adjuvant radiation is often recommended. These tumors can rarely secrete metanephrines and normetanephrines which can complicate operative management. Here we present two cases of clival paragangliomas with unique clinical presentations and review the previous literature on skull base paragangliomas.
authors.affiliation: Department of Neurological Surgery, The University of Washington, 908 Jefferson St, Seattle, WA, 98104, USA. Ruzevick@uw.edu.
authors.forename: Jacob
authors.identifier: 0000-0002-6968-5576
authors.initials: J
authors.lastname: Ruzevick
authors.affiliation: Division of Endocrinology, The University of Washington, Seattle, WA, USA.
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Koh
authors.affiliation: Division of Neuropathology, Department of Pathology, The University of Washington, Seattle, WA, USA.
authors.forename: Luis F
authors.initials: LF
authors.lastname: Gonzalez-Cuyar
authors.affiliation: Division of Neuropathology, Department of Pathology, The University of Washington, Seattle, WA, USA.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Cimino
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The University of Washington, Seattle, WA, USA.
authors.forename: Kristen
authors.initials: K
authors.lastname: Moe
authors.affiliation: Division of Endocrinology, The University of Washington, Seattle, WA, USA.
authors.forename: Lorena A
authors.initials: LA
authors.lastname: Wright
authors.affiliation: Division of Endocrinology, The University of Washington, Seattle, WA, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Failor
authors.affiliation: Department of Neurological Surgery, The University of Washington, 908 Jefferson St, Seattle, WA, 98104, USA.
authors.forename: Manuel
authors.initials: M
authors.lastname: Ferreira
mesh_terms: D000368:Aged; D003388:Cranial Fossa, Posterior / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D010236:Paraganglioma, Extra-Adrenal / Q000473:pathology* / Q000601:surgery; D019292:Skull Base Neoplasms / Q000473:pathology* / Q000601:surgery
keywords: Catecholamine-secreting tumor; Paraganglioma; Skull base tumors