title: Contribution of type III interferons to antiviral immunity: location, location, location.
abstract: Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as the first line of defense against virus infection and regulate the development of both innate and adaptive immune responses. Type III IFNs were originally identified as a novel ligand-receptor system acting in parallel with type I IFNs, but subsequent studies have provided increasing evidence for distinct roles for each IFN family. In addition to their compartmentalized antiviral actions, these two systems appear to have multiple levels of cross-regulation and act coordinately to achieve effective antimicrobial protection with minimal collateral damage to the host.
authors.affiliation: From the Departments of Microbiology, Biochemistry and Molecular Genetics and kotenkse@njms.rutgers.edu.|Center for Immunity and Inflammation, and.|University Hospital Cancer Center, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers, Newark, New Jersey 07103.
authors.forename: Sergei V
authors.initials: SV
authors.lastname: Kotenko
authors.affiliation: Center for Immunity and Inflammation, and durbinje@njms.rutgers.edu.|University Hospital Cancer Center, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers, Newark, New Jersey 07103.|Pathology and Laboratory Medicine.
authors.forename: Joan E
authors.initials: JE
authors.lastname: Durbin
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000276:immunology; D007372:Interferons; D007378:Interleukins / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*; D000095022:Interferon Lambda
chemical_list: D007370:Interferon Type I; D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda
keywords: antiviral agent; interferon; mucosal immunology; viral immunology; virology