title: Lutetium177PSMA radionuclide therapy for men with prostate cancer: a review of the current literature and discussion of practical aspects of therapy.
abstract: Prostate-specific membrane antigen (PSMA) is a receptor on the surface of prostate cancer cells that is revolutionising the way we image and treat men with prostate cancer. New small molecule peptides with high-binding affinity for the PSMA receptor have allowed high quality, highly specific PET imaging, in addition to the development of targeted radionuclide therapy for men with prostate cancer. This targeted therapy for prostate cancer has, to date, predominately used Lutetium 177 (Lu) labelled PSMA peptides. Early clinical studies evaluating the safety and efficacy of Lu PSMA therapy have demonstrated promising results with a significant proportion of men with metastatic prostate cancer, who have already failed other therapies, responding clinically to Lu PSMA. This review discusses the practical issues of administering Lu PSMA, and gives an overview of the findings from currently published trials in regards to treatment response rates, expected toxicities and safety.
authors.affiliation: University of New South Wales, Sydney, NSW, Australia.|Garvan Institute of Medical Research, Darlinghurst, Australia.
authors.forename: Louise
authors.identifier: http://orcid.org/0000-0002-4895-7384
authors.initials: L
authors.lastname: Emmett
authors.affiliation: Institute of Medical Physics, The University of Sydney, Sydney, NSW, Australia.
authors.forename: Kathy
authors.initials: K
authors.lastname: Willowson
authors.affiliation: Peter McCallum Cancer Institute, Melbourne, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Violet
authors.affiliation: St Vincent's Hospital, Sydney, Australia.
authors.forename: Jane
authors.initials: J
authors.lastname: Shin
authors.affiliation: St Vincent's Hospital, Sydney, Australia.
authors.forename: Ashley
authors.initials: A
authors.lastname: Blanksby
authors.affiliation: St Vincent's Hospital, Sydney, Australia.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lee
mesh_terms: D000954:Antigens, Surface / Q000378:metabolism*; D043425:Glutamate Carboxypeptidase II / Q000378:metabolism*; D006801:Humans; D008187:Lutetium / Q000627:therapeutic use*; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods*; D011879:Radiotherapy Dosage; D012449:Safety
chemical_list: D000954:Antigens, Surface; D008187:Lutetium; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II
keywords: Lutetium; PSMA; prostate cancer; theranostics