title: Precise determination of the heat delivery during in vivo magnetic nanoparticle hyperthermia with infrared thermography.
abstract: Non-invasive and real-time monitoring of the heat delivery during magnetic nanoparticle hyperthermia (MNH) is of fundamental importance to predict clinical outcomes for cancer treatment. Infrared thermography (IRT) can determine the surface temperature due to three-dimensional heat delivery inside a subcutaneous tumor, an argument that is supported by numerical simulations. However, for precise temperature determination, it is of crucial relevance to use a correct experimental configuration. This work reports an MNH study using a sarcoma 180 murine tumor containing 3.9 mg of intratumorally injected manganese-ferrite nanoparticles. MNH was performed at low field amplitude and non-uniform field configuration. Five 30 min in vivo magnetic hyperthermia experiments were performed, monitoring the surface temperature with a fiber optical sensor and thermal camera at distinct angles with respect to the animal's surface. The results indicate that temperature errors as large as [Formula: see text]C can occur if the experiment is not properly designed. A new IRT error model is found to explain the data. More importantly, we show how to precisely monitor temperature with IRT during hyperthermia, which could positively impact heat dosimetry and clinical planning.
authors.affiliation: Universidade Federal de Goiás, Goiânia, GO 74690-900 Brazil.
authors.forename: Harley F
authors.initials: HF
authors.lastname: Rodrigues
authors.forename: Gustavo
authors.initials: G
authors.lastname: Capistrano
authors.forename: Francyelli M
authors.initials: FM
authors.lastname: Mello
authors.forename: Nicholas
authors.initials: N
authors.lastname: Zufelato
authors.forename: Elisângela
authors.initials: E
authors.lastname: Silveira-Lacerda
authors.forename: Andris F
authors.initials: AF
authors.lastname: Bakuzis
mesh_terms: D000818:Animals; D005290:Ferric Compounds / Q000737:chemistry; D006358:Hot Temperature; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays; D059346:Magnets / Q000737:chemistry*; D008297:Male; D017895:Manganese Compounds / Q000737:chemistry; D051379:Mice; D053758:Nanoparticles; D009369:Neoplasms / Q000628:therapy; D013696:Temperature; D013817:Thermography
chemical_list: D005290:Ferric Compounds; D017895:Manganese Compounds; C551151:manganese ferrite