title: Natural Products from Deep-Sea-Derived Fungi ̶ A New Source of Novel Bioactive Compounds?
abstract: BACKGROUND
  Over the last two decades, deep-sea-derived fungi are considered to be a new source of pharmacologically active secondary metabolites for drug discovery mainly based on the underlying assumption that the uniqueness of the deep sea will give rise to equally unprecedented natural products. Indeed, up to now over 200 new metabolites have been identified from deep-sea fungi, which is in support of the statement made above.
  
  
  RESULTS
  This review summarizes the new and/or bioactive compounds reported from deepsea- derived fungi in the last six years (2010 - October 2016) and critically evaluates whether the data published so far really support the notion that these fungi are a promising source of new bioactive chemical entities.
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany.
authors.forename: Georgios
authors.initials: G
authors.lastname: Daletos
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany.
authors.forename: Weaam
authors.initials: W
authors.lastname: Ebrahim
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany.
authors.forename: Elena
authors.initials: E
authors.lastname: Ancheeva
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
authors.forename: Mona
authors.initials: M
authors.lastname: El-Neketi
authors.affiliation: Fukang Pharma North-East of Dongwaihuan Road, Dongcheng Industrial Area, 262700 Shouguang City, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Song
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001688:Biological Products
keywords: Deep-sea fungi; bioactive metabolites; bioprospecting; drug discovery; extremophiles; natural products