title: Microwave-assisted Olefin Metathesis as Pivotal Step in the Synthesis of Bioactive Compounds.
abstract: Over the last two decades, olefin metathesis has emerged as a new avenue in the design of new routes for the synthesis of natural products and active pharmaceutical ingredients. In many cases, syntheses based on olefin metathesis strategies provide significant routes in terms of increasing the overall yields, improving the synthesis scope, and decreasing the number of steps. On the other hand, over the last decade, microwave-assisted chemistry has experienced an incredible development, which rapidly opened new areas in organic synthesis and in homogeneous catalysis. In this review article, we highlight applications of microwaveheated olefin metathesis reactions as pivotal steps in the total synthesis of biologically active compounds. By drawing selected examples from the recent literature, we aim to illustrate the great synthetic power and variety of metathesis reactions, as well as the beneficial effects of microwave irradiation over conventional heating sources. The majority of the selected applications of microwave-assisted olefin metathesis cover the synthesis of medium-ring cycles, macrocycles, and peptidomimetics by means of ring-closing metathesis (RCM) and crossmetathesis (CM) routes.
authors.affiliation: Laboratory of Macromolecular Chemistry and Organic Catalysis, Department of Chemistry, University of Liege, Sart-Tilman (B.6a), B-4000 Liege, Belgium.
authors.forename: Koffi Senam
authors.initials: KS
authors.lastname: Etse
authors.affiliation: Laboratory of Macromolecular Chemistry and Organic Catalysis, Department of Chemistry, University of Liege, Sart-Tilman (B.6a), B-4000 Liege, Belgium.
authors.forename: Alice
authors.initials: A
authors.lastname: Ngendera
authors.affiliation: Laboratory of Macromolecular Chemistry and Organic Catalysis, Department of Chemistry, University of Liege, Sart-Tilman (B.6a), B-4000 Liege, Belgium.
authors.forename: Nelly Tshibalonza
authors.initials: NT
authors.lastname: Ntumba
authors.affiliation: Laboratory of Macromolecular Chemistry and Organic Catalysis, Department of Chemistry, University of Liege, Sart-Tilman (B.6a), B-4000 Liege, Belgium.
authors.forename: Albert
authors.initials: A
authors.lastname: Demonceau
authors.affiliation: Laboratory of Organometallic Chemistry and Homogeneous Catalysis, Department of Chemistry, University of Liege, Sart-Tilman (B.6a), B-4000 Liege, Belgium.
authors.forename: Lionel
authors.initials: L
authors.lastname: Delaude
authors.affiliation: Institute of Organic Chemistry of the Romanian Academy, 202B Spl. Independentei, 060023 Bucharest, P.O. Box 35-108, Romania.
authors.forename: Ileana
authors.initials: I
authors.lastname: Dragutan
authors.affiliation: Institute of Organic Chemistry of the Romanian Academy, 202B Spl. Independentei, 060023 Bucharest, P.O. Box 35-108, Romania.
authors.forename: Valerian
authors.initials: V
authors.lastname: Dragutan
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure
chemical_list: D000475:Alkenes; D001688:Biological Products
keywords: Cross-metathesis; microwaves; natural products; olefin metathesis; ring-closing metathesis; ruthenium
  catalysts