title: Anti-EGFRvIII Chimeric Antigen Receptor-Modified T Cells for Adoptive Cell Therapy of Glioblastoma.
abstract: Glioblastoma (GBM) is one of the most devastating brain tumors with poor prognosis and high mortality. Although radical surgical treatment with subsequent radiation and chemotherapy can improve the survival, the efficacy of such regimens is insufficient because the GBM cells can spread and destroy normal brain structures. Moreover, these non-specific treatments may damage adjacent healthy brain tissue. It is thus imperative to develop novel therapies to precisely target invasive tumor cells without damaging normal tissues. Immunotherapy is a promising approach due to its capability to suppress the growth of various tumors in preclinical model and clinical trials. Adoptive cell therapy (ACT) using T cells engineered with chimeric antigen receptor (CAR) targeting an ideal molecular marker in GBM, e.g. epidermal growth factor receptor type III (EGFRvIII) has demonstrated a satisfactory efficacy in treating malignant brain tumors. Here we summarize the recent progresses in immunotherapeutic strategy using CAR-modified T cells oriented to EGFRvIII against GBM.
authors.affiliation: Translational Research Center, People's Hospital of Henan Province, Zhengzhou University, Zhengzhou 450003, China.
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Ren
authors.affiliation: Departmentt of Neurosurgery, People's Hospital of Henan Province, Zhengzhou University, Zhengzhou 450003, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450003, China.
authors.forename: Tian-Fang
authors.initials: TF
authors.lastname: Li
authors.affiliation: Translational Research Center, People's Hospital of Henan Province, Zhengzhou University, #7 Weiwu Road, Zhengzhou 450003, China; and Dr. Tian-Fnag Li, The First Affiliated Hospital of Zhengzhou University, #1 Jianshe Road, Zhengzhou 450003, China.
authors.forename: Shuang-Yin
authors.initials: SY
authors.lastname: Han
mesh_terms: D001932:Brain Neoplasms / Q000276:immunology / Q000628:therapy*; D060846:Cell Engineering; D064987:Cell- and Tissue-Based Therapy; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000276:immunology; D005909:Glioblastoma / Q000276:immunology / Q000628:therapy*; D006801:Humans; D016219:Immunotherapy, Adoptive; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation*
chemical_list: D011948:Receptors, Antigen, T-Cell; C410723:epidermal growth factor receptor VIII; D066246:ErbB Receptors
keywords: EGFRvIII; adoptive cell therapy; chimeric antigen receptor; glioblastoma.