title: Effect of metformin on exercise capacity in metabolic syndrome.
abstract: OBJECTIVE
  Metabolic syndrome is a constellation of risk factors with increased predilection towards occurrence of cardiovascular diseases. Currently physical exercise and management with metformin are the prevailing treatment modalities for metabolic syndrome. Patients with metabolic syndrome have been found to have reduced exercise capacity over a period of time. Likewise metformin has been shown to decrease exercise capacity among healthy volunteers. Hence this study aims to evaluate the effect of metformin on the exercise capacity of patients with metabolic syndrome.
  
  
  METHODS
  Prospective study with 6 weeks follow up.
  
  
  METHODS
  Newly diagnosed patients with metabolic syndrome and to be started on Table Metformin 500mg twice a day were recruited for the study after obtaining written informed consent. Cardiopulmonary Exercise Testing (CPET) was done at baseline before the subjects were started on metformin and after 6 weeks of treatment using cardiopulmonary exercise testing apparatus (ZAN600).
  
  
  RESULTS
  Fifteen treatment naïve patients with metabolic syndrome completed six weeks of therapy with metformin. In these patients oxygen uptake [VO2] showed statistically significant decrease from 1.10±0.44 at baseline to 0.9±0.39 (l/min) after six weeks of treatment with metformin [mean difference of -0.20 (-0.31 to -0.09); P=0.001]. Similarly oxygen uptake/kg body weight [VO2/Kg] showed a significant decrease from 14.10±4.73 to 11.44±3.81 (mlkg-1min-1) at the end of six weeks of treatment [mean difference of -2.66 (-4.06 to -1.26); P=0.001].
  
  
  CONCLUSIONS
  Six weeks of treatment with metformin significantly decreases exercise capacity in newly diagnosed patients with metabolic syndrome.
authors.affiliation: Pharmacology, Medical University of Americas, Nevis, WI, United States; Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India(1). Electronic address: dr.abialbon@gmail.com.
authors.forename: Abi Albon
authors.initials: AA
authors.lastname: Paul
authors.affiliation: Dept of Pharmacology, JIPMER, Puducherry, India; Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India(1). Electronic address: steven_d44@rediffmail.com.
authors.forename: Steven Aibor
authors.initials: SA
authors.lastname: Dkhar
authors.affiliation: Dept of Endocrinology, JIPMER, Puducherry, India; Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India(1). Electronic address: sadishkk@gmail.com.
authors.forename: Sadishkumar
authors.initials: S
authors.lastname: Kamalanathan
authors.affiliation: Dept of Medicine, JIPMER, Puducherry, India; Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India(1). Electronic address: thabah.m@jipmer.edu.in.
authors.forename: Molly Mary
authors.initials: MM
authors.lastname: Thabah
authors.affiliation: Dept of Clinical Pharmacology, SRMMC&RI, Chennai, India; Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India(1). Electronic address: melvingeorge2003@gmail.com.
authors.forename: Melvin
authors.initials: M
authors.lastname: George
authors.affiliation: Dept of Pharmacology, JIPMER, Puducherry, India; Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India(1). Electronic address: insnewlook@yahoo.co.in.
authors.forename: Indumathi
authors.initials: I
authors.lastname: Chandrasekaran
authors.affiliation: Dept of Clinical Pharmacology, JIPMER, Puducherry, India; Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India(1). Electronic address: vikneswaran786@gmail.com.
authors.forename: Vikneswaran
authors.initials: V
authors.lastname: Gunaseelan
authors.affiliation: Dept of Clinical Pharmacology, JIPMER, Puducherry, India; Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India(1). Electronic address: sandhiyaselvarajan@gmail.com.
authors.forename: Sandhiya
authors.initials: S
authors.lastname: Selvarajan
mesh_terms: D005080:Exercise Test; D005081:Exercise Therapy; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000628:therapy*; D008687:Metformin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin
keywords: Exercise capacity; Metabolic syndrome; Metformin