title: [Value of Two Dimensional Echocardiography for Assessment of Disease Severity in Patients With Pulmonary Hypertension].
abstract: To carry out complex assessment of the right ventricular (RV) function with two-dimensional echocardiography (2D-EchoCG) for detection of most informative markers of the disease severity in patients with pulmonary hypertension (PH).
  
  
  
  We examined 63 patients with PH (38 with idiopathic PH, 7 with corrected congenital heart defects, 6 with systemic scleroderma, 12 with chronic inoperable thromboembolic PY). Examination included right heart catheterization, 2D-EchoCG, and cardiac magnetic resonance tomography (MRT).
  
  
  
  2D-EchoCG revealed dilation of right chambers of the heart, hypertrophy of RV anterior wall, increase of ratio of right to left ventricular end-diastolic dimensions (RV:LV), reduction of LV stroke volume, diminution of amplitude and velocity of tricuspid annular plane systolic excursion, and significant increase of myocardial performance index Tei. MRT data evidenced for lowering of RV ejection fraction. Canonical correlation was found between integral characteristic of 2D-EchoCG and integral hemodynamic characteristic (r=0.77; p=0.007). We also determined threshold values of RV: LV to be used for stratification of risk in patients with PH.
  
  
  
  In patienns with PH calculation of simple 2D-EchoCG parameters provides information important for determination of disease severity, selection of optimal method of treatment, and monitoring of patients condition.
authors.affiliation: 1Almazov Federal North-West Medical Research Centre, Saint-Petersburg, Russia; 2Institute of Translational Medicine ITMO University, St-Petersburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kyzymly
authors.affiliation: 1Almazov Federal North-West Medical Research Centre, Saint-Petersburg, Russia; 2Institute of Translational Medicine ITMO University, St-Petersburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Ryzhkov
authors.affiliation: 1Almazov Federal North-West Medical Research Centre, Saint-Petersburg, Russia; 2Institute of Translational Medicine ITMO University, St-Petersburg, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Simakova
authors.affiliation: 1Almazov Federal North-West Medical Research Centre, Saint-Petersburg, Russia; 2Institute of Translational Medicine ITMO University, St-Petersburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kozlyonok
authors.affiliation: 1Almazov Federal North-West Medical Research Centre, Saint-Petersburg, Russia; 2Institute of Translational Medicine ITMO University, St-Petersburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Naimushin
authors.affiliation: 1Almazov Federal North-West Medical Research Centre, Saint-Petersburg, Russia; 2Institute of Translational Medicine ITMO University, St-Petersburg, Russia.
authors.forename: O M
authors.initials: OM
authors.lastname: Moiseeva
mesh_terms: D006328:Cardiac Catheterization; D004452:Echocardiography; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013318:Stroke Volume; D016278:Ventricular Function, Right