title: Pseudohypoparathyroidism with basal ganglia calcification: A case report of rare cause of reversible parkinsonism.
abstract: BACKGROUND
  Parkinsonism can be secondary to many internal diseases, in some certain conditions, it seems that the clinical manifestations of parkinsonism presenting reversible. We report a case of patient with parkinsonism secondary to pseudohypoparathyroidism, who improved markedly after the supplement of serum calcium.
  
  
  METHODS
  A 52-year-old woman with acute parkinsonism was diagnosed as pseudohypoparathyroidism after the conducting of brain computed tomography, laboratory examinations, and gene detection. The son of the patient was also examined and was diagnosed as pseudohypoparathyroidism, who had ever complained of the history of epilepsy. The clinical manifestations of parkinsonism of the patient was reevaluated after the supplement of serum calcium according to the diagnosis.
  
  
  RESULTS
  The brain computed tomography revealed the basal ganglia calcification of the patient, accompanying by serum hypocalcemia and hyperphosphatemia. Loss of function mutation also confirmed the diagnosis. Five days after the therapy targeting at correction of serum hypocalcemia, the patient improved greatly in dyskinesia.
  
  
  CONCLUSIONS
  This study reported a patient presenting as acute reversible parkinsonism, who was finally diagnosed as pseudohypoparathyroidism. It indicated us that secondary parkinsonism should be carefully differentiated for its dramatic treatment effect. And the family history of seizures might be an indicator for the consideration of pseudohypoparathyroidism.
authors.affiliation: Department of Neurology, Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Cheng-Yuan
authors.initials: CY
authors.lastname: Song
authors.forename: Zhen-Xiang
authors.initials: ZX
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Cong-Cong
authors.initials: CC
authors.lastname: Sun
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Liu
mesh_terms: D001480:Basal Ganglia Diseases / Q000150:complications; D002114:Calcinosis / Q000150:complications; D002118:Calcium / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000208:ethnology*; D011547:Pseudohypoparathyroidism / Q000150:complications* / Q000188:drug therapy
chemical_list: D002118:Calcium