title: Trypanothione Reductase: A Target for the Development of Anti- Trypanosoma cruzi Drugs.
abstract: OBJECTIVE
  Chagas disease or American trypanosomiasis is a major parasitic disease in Latin America with restricted available treatment: nifurtimox and benznidazole. These two drugs are ineffective in the chronic phase of the disease; therefore, there is a need for the development of new, efficient and safe drugs for the treatment of this pathology. With this goal, one of the promising targets is trypanothione reductase (TR), a key enzyme in the metabolism of Trypanosoma cruzi.
  
  
  CONCLUSIONS
  In this review, we analyse the importance of TR as a drug target, as well as the well-known and new inhibitors reported in the last decade as potential therapeutic agents for Chagas disease.
authors.affiliation: Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, Escobedo, 66050, Mexico.
authors.forename: Karina
authors.initials: K
authors.lastname: Vázquez
authors.affiliation: Centro de Bioinformática Estructural DETEMA, Facultad de Química, Universidad de la Republica, P.O. 1157, Montevideo, Uruguay.
authors.forename: Margot
authors.initials: M
authors.lastname: Paulino
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Santiago, 6094411, Chile.
authors.forename: Cristian O
authors.initials: CO
authors.lastname: Salas
authors.affiliation: Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, Escobedo, 66050, Mexico.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Zarate-Ramos
authors.affiliation: Centro de Bioinformática Estructural DETEMA, Facultad de Química, Universidad de la Republica, P.O. 1157, Montevideo, Uruguay.
authors.forename: Brenda
authors.initials: B
authors.lastname: Vera
authors.affiliation: Centro de Biotecnologia Genomica, Instituto Politecnico Nacional, Boulevard del Maestro, s/n, Esquina Elías Piña, Reynosa, 88710, Mexico.
authors.forename: Gildardo
authors.initials: G
authors.lastname: Rivera
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy*; D016503:Drug Delivery Systems; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D009547:Nifurtimox / Q000737:chemistry / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000201:enzymology*
chemical_list: D004791:Enzyme Inhibitors; D014344:Trypanocidal Agents; D009247:NADH, NADPH Oxidoreductases; C049608:trypanothione reductase; D009547:Nifurtimox
keywords: Chagas disease; Trypanosoma cruzi; drugs; inhibitors; target; trypanothione reductase