title: Ghanamycins A and B, two novel γ-butyrolactones from marine-derived streptomyces ghanaensis TXC6-16.
abstract: Two novel γ-butyrolactones ghanamycins A (1) and B (2) were isolated from the fermentation broth of marine-derived Streptomyces ghanaensis TXC6-16. Their structures were elucidated by spectroscopic analysis. These two novel compounds exhibited antimicrobial activities against some phytopathogens. The minimum IC (MIC) of 2 against Pseudomonas syringae and Erwinia sp. were 50 μg ml-1.
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
authors.forename: Jia-Hui
authors.initials: JH
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
authors.forename: Kang-Bo
authors.initials: KB
authors.lastname: Gu
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
authors.forename: Dao-Jing
authors.initials: DJ
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
authors.forename: Yuan-Guang
authors.initials: YG
authors.lastname: Li
authors.affiliation: First Institute of Oceanography, State Oceanic Administration, Qingdao, China.
authors.forename: Li
authors.initials: L
authors.lastname: Tian
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004885:Erwinia / Q000187:drug effects; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D044224:Pseudomonas syringae / Q000187:drug effects; D013057:Spectrum Analysis; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; C000621050:ghanamycin A; C000621051:ghanamycin B; D015107:4-Butyrolactone