title: Stereoselective and nonstereoselective pharmacokinetics of rabeprazole - an overview.
abstract: 1. Proton pump inhibitors have been extensively used for the treatment of ailments due to increased gastric acid secretion such as peptic ulcers, gastroesophageal reflux disease, etc. 2. There are several approved drugs in the proton pump inhibitor class with the latest entries representing single enantiomer drugs of the previously approved racemic drugs. 3. Despite having a high degree of structural resemblance, rabeprazole, was shown to possess some unique differentiation from other drugs in the class. One of the key distinguishing features of rabeprazole was related to the lesser involvement of polymorphic metabolism in its pharmacokinetic disposition. 4. The review was aimed to provide pharmacokinetic data of rabeprazole from several clinical studies including drug-drug interaction studies where rabeprazole was either a perpetrator drug or victim drug. 5. Additional perspectives on therapy considerations due to the unique metabolic disposition of rabeprazole including the possible issues related to chirality were provided.
authors.affiliation: a Department of Metabolism and Pharmacokinetics , Johns Hopkins Drug Discovery Program and Johns Hopkins University , Baltimore , MD , USA.|b Department of Neurology , Johns Hopkins University , Baltimore , MD , USA , and.
authors.forename: Ranjeet Prasad
authors.initials: RP
authors.lastname: Dash
authors.affiliation: a Department of Metabolism and Pharmacokinetics , Johns Hopkins Drug Discovery Program and Johns Hopkins University , Baltimore , MD , USA.|b Department of Neurology , Johns Hopkins University , Baltimore , MD , USA , and.
authors.forename: Rana
authors.initials: R
authors.lastname: Rais
authors.affiliation: c Department of Metabolism and Pharmacokinetics , Zydus Research Centre , Ahmedabad , Gujarat , India.
authors.forename: Nuggehally R
authors.initials: NR
authors.lastname: Srinivas
mesh_terms: D000818:Animals; D004347:Drug Interactions; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000378:metabolism*; D054328:Proton Pump Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D064750:Rabeprazole / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors; D064750:Rabeprazole
keywords: Clinical; drug interaction; enantiomer; pharmacokinetics; rabeprazole