title: The Comparison of the Effects of Nebivolol and Metoprolol on Erectile Dysfunction in the Cases with Coronary Artery Bypass Surgery.
abstract: OBJECTIVE
  Beta-blocker use is common in the cases with coronary artery bypass surgery. According to the literature, beta-blockers have positive effects but may cause erectile dysfunction (ED). The most commonly used beta-blockers in ischemic cardiac disease are nebivolol and metoprolol. In our clinic, we aimed to compare the effects of nebivolol and metoprolol succinate on ED in the sexually active cases with coronary artery bypass surgery.
  
  
  METHODS
  In our clinic, a total of 119 patients with coronary artery bypass surgery were included in the study. International Index of Erectile Function (IIEF-5) Test was used to evaluate whether the patients had ED and to grade the cases.
  
  
  RESULTS
  No significant difference was found in terms of anti-ischemic efficacy between metoprolol succinate and nebivolol in the postoperative period; however, the incidence of any grade ED was %85.96 in Group 1, %83.87 in Group 2. This difference was considered as statistically significant (p = 0.036).
  
  
  CONCLUSIONS
  Beta-blocker use increases the risk of ED in cases with ischemic cardiac disease. We suggest that the complaints of ED could be less frequent with nebivolol use in sexually active cases with ischemic cardiac disease.
authors.affiliation: Department of Cardiovascular Surgery, Namik Kemal University, Tekirdag, Turkey.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Gür
authors.affiliation: Department of Cardiovascular Surgery, Namik Kemal University, Tekirdag, Turkey.
authors.forename: Selami
authors.initials: S
authors.lastname: Gurkan
authors.affiliation: Department of Cardiovascular Surgery, Namik Kemal University, Tekirdag, Turkey.
authors.forename: Gunduz
authors.initials: G
authors.lastname: Yumun
authors.affiliation: Department of Urology, Namik Kemal University, Tekirdag, Turkey.
authors.forename: Polat
authors.initials: P
authors.lastname: Turker
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D007172:Erectile Dysfunction / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000009:adverse effects*; D008875:Middle Aged; D000068577:Nebivolol / Q000009:adverse effects*; D010410:Penile Erection / Q000187:drug effects*; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D000068577:Nebivolol; D008790:Metoprolol
keywords: beta-blocker; coronary artery bypass surgery; erectile dysfunction