title: Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.
abstract: Antioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the Curcuma longa were simultaneously tested and compared in this study. The highest antioxidant power was detected for curcumin with the applied methods. The drug potentials of curcuminoids for Alzheimer's disease were controlled. Bisdemethoxycurcumin (BDMC) showed substantial inhibitory activity. The activity of demethoxycurcumin (DMC) followed BDMC, whereas curcumin showed very little acetylcholinesterase inhibition activity. Antidiabetic activity of curcuminoids was evaluated by their α-glucosidase inhibitory activities. All curcuminoids show activities with decreasing order as BDMC > curcumin > DMC. The significant activities of BDMC compared to its isomers and examination of chemical structures of isomers might be a starting point in designing new drugs for Alzheimer's and Diabetes Mellitus.
authors.affiliation: a Department of Chemistry , Istanbul Technical University , Istanbul , Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Kalaycıoğlu
authors.affiliation: b Faculty of Pharmacy, Department of Analytical Chemistry , Bezmialem Vakıf University , Istanbul , Turkey.
authors.forename: Işıl
authors.initials: I
authors.lastname: Gazioğlu
authors.affiliation: a Department of Chemistry , Istanbul Technical University , Istanbul , Turkey.
authors.forename: F Bedia
authors.initials: FB
authors.lastname: Erim
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000031:analogs & derivatives / Q000494:pharmacology; D036381:Diarylheptanoids; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D036381:Diarylheptanoids; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D010936:Plant Extracts; C034786:bisdemethoxycurcumin; D003474:Curcumin; C050229:demethoxycurcumin
keywords: Turmeric; acetylcholinesterase; bioactivity; bisdemethoxycurcumin; curcumin; demethoxycurcumin