title: [Combination Therapy of Pregabalin with Tramadol for Treatment of Peripheral Neuropathy in Patients with Gynecological Cancer Receiving Taxane Containing Chemotherapy].
abstract: Taxane-based regimens are often used in gynecologic cancer chemotherapy. Chemotherapy-induced peripheral neuropathy( CIPN)is one of the typical side effects caused by taxanes. Grade 2 or higher CIPN is observed in 5% to 30% of ovarian cancer patients who are treated with paclitaxel, which is recognized as one of the unmanageable side effects leading to treatment interruption. We retrospectively investigated the significance of combination therapy of pregabalin with tramadol for CIPN in patients with gynecological cancer. In the current study, 19 patients(19/22; 86%)were administered pregabalin with tramadol orally for at least 1week, and we observed improvement of the CIPN in 15 patients(15/19; 79%).We suggest that the combination therapy of pregabalin with tramadol has a positive impact on the CIPN in patients under a taxane-based chemotherapy.
authors.affiliation: Dept. of Gynecologic Oncology, Saitama Medical University International Medical Center.
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Kosei
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shintani
authors.forename: Yuri
authors.initials: Y
authors.lastname: Yano
authors.forename: Sho
authors.initials: S
authors.lastname: Sato
authors.forename: Akira
authors.initials: A
authors.lastname: Yabuno
authors.forename: Akira
authors.initials: A
authors.lastname: Kurosaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshida
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fujiwara
mesh_terms: D000328:Adult; D000368:Aged; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000517:prevention & control*; D000069583:Pregabalin / Q000627:therapeutic use*; D012189:Retrospective Studies; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use; D014147:Tramadol / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000188:drug therapy*
chemical_list: D004338:Drug Combinations; D043823:Taxoids; D014147:Tramadol; D000069583:Pregabalin