title: Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-1.
abstract: The aim of this study is to investigate the mechanisms of Chinese herbal medicine called "Baoyuan Jiedu" (BYJD for short) decoction, improving life quality and preventing muscle atrophy of cancer cachexia model mice. We showed that the effect of BYJD decoction increased body weights of mice and reduced tumor volume and tumor mass. Furthermore, BYJD decoction increased the gastrocnemii mass and the transverse diameter of muscle fiber morphology. Moreover, BYJD reduced the expression of Atrogin-1 and MuRF-1 protein. Collectively, our results show that BYJD decoction improves the life quality of cancer cachexia mice and prevents muscle atrophy by downregulating expression of Atrogin-1 and MuRF-1.
authors.affiliation: College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.
authors.forename: YaNan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.
authors.forename: XiaoChun
authors.initials: X
authors.lastname: Han
authors.affiliation: Shandong Food and Drug Administration, Jinan, Shandong 250014, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Ouyang
authors.affiliation: College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.
authors.forename: ZhiChun
authors.initials: Z
authors.lastname: Wu
authors.affiliation: College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.
authors.forename: HuaYun
authors.initials: H
authors.lastname: Yu
authors.affiliation: College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Foreign Language, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.
authors.forename: GuoWei
authors.initials: G
authors.lastname: Liu
authors.affiliation: College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.
authors.forename: XuMing
authors.identifier: 0000-0002-3328-6469
authors.initials: X
authors.lastname: Ji