title: [Ability to Overcome the Thrombocyte Resistance to Acetylsalicylic Acid in Patients With Coronary Artery Disease After Myocardial Revascularization With Coronary Stenting].
abstract: Resistance to acetylsalicylic acid (ASA) in patients with coronary artery disease is a poor predictor for the development of atherothrombotic complications. In 277 patients with coronary artery disease suffered uncomplicated coronary angioplasty with stent implantation, we was estimated arachidon-induced platelet aggregation during treatment with acetylsalicylic acid by bedside VerifyNow Assay test at 28-90 days after the intervention. It was found that 18.9% of the 144 patients receiving a combination of ASA 75 mg with 15.2 mg of magnesium hydroxide had true (laboratory) resistance to ASA. At the same time on the original enteric coated ASA 100 mg, we can found only 0.8% resistance to ASA among 129 patients. We made switch from combination of ASA 75 mg with 15.2 mg of magnesium hydroxide to original enteric coated ASA 100 mg and repeat VerifyNow Assay test at 2-4 days and found lost of resistance in 92% of 28 patients. Thus, resistance to the ASA is not constant, it depends on the form and the applied dose of ASA, and eliminating more than 92% when ASA changes from ineffective to effective form.
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: I V
authors.initials: IV
authors.lastname: Pershukov
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: S L
authors.initials: SL
authors.lastname: Ostaschenko
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: T N
authors.initials: TN
authors.lastname: Kuznetsova
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: S N
authors.initials: SN
authors.lastname: Scherbo
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Karben
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: E V
authors.initials: EV
authors.lastname: Sokryukina
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: A A
authors.initials: AA
authors.lastname: Omarov
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: D M
authors.initials: DM
authors.lastname: Ramazanov
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: N V
authors.initials: NV
authors.lastname: Bosak
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: L V
authors.initials: LV
authors.lastname: Shulzhenko
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: R K
authors.initials: RK
authors.lastname: Kalmatov
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: T A
authors.initials: TA
authors.lastname: Batyraliev
authors.affiliation: Central State Medical Academy, President Management Department RF, Moscow, Russia.|Voronezh Regional Clinical Hospital 1, Voronezh, Russia.|N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.|Sani Konukoglu Medical Center, Gaziantep ,Turkey.|Scientific and Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.|Central Hospital of Oilworkers, Baku, Azerbaijan.|Krasnodar City Emergency Clinical Hospital, Krasnodar, Russia.|Kuban State Medical University, Krasnodar, Russia.|Osh State University, Osh, Kyrgyzstan.
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000601:surgery; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D015607:Stents
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin
keywords: VerifyNow; acetylsalicylic acid; coronary artery disease; coronary stenting; laboratory resistance