title: The role of interleukin-17A in the pathogenesis of kidney diseases.
abstract: Being a member of the IL-17 family, comprising six structurally related ligands, IL-17A is a cytokine, produced by multiple cell types, such as CD4+αβ T cells, γδ T cells, natural killer cells, neutrophils, macrophages, dendritic cells, lymphoid tissue inducer cells, mast cells and plasma cells. IL-17A participates in tissue inflammation by inducing the expression of chemokines, proinflammatory cytokines and matrix metalloproteases. Besides its role in host defence against infectious diseases, IL-17A is involved in different autoimmune and inflammatory diseases. In this review, we will highlight the role of IL-17A in the pathogenesis of acute and chronic kidney diseases. Due to its pleiotropic character, IL-17A is involved in the development of atherosclerosis, hypertension, diabetic nephropathy, ischaemia-reperfusion injury, fibrosis, glomerulonephritis, nephrotic syndrome, minimal change disease and acute renal allograft rejection. In addition, inhibition of IL-17A may be a promising therapeutic target to prevent end-stage renal disease.
authors.affiliation: Department of Nephrology, Ghent University Hospital, Ghent, Belgium.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Cortvrindt
authors.affiliation: Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
authors.forename: Reinhart
authors.initials: R
authors.lastname: Speeckaert
authors.affiliation: Department of Clinical Chemistry, Ghent University Hospital, Ghent, Belgium.
authors.forename: Alena
authors.initials: A
authors.lastname: Moerman
authors.affiliation: Department of Clinical Chemistry, Ghent University Hospital, Ghent, Belgium.
authors.forename: Joris R
authors.initials: JR
authors.lastname: Delanghe
authors.affiliation: Department of Nephrology, Ghent University Hospital, Ghent, Belgium. Electronic address: marijn.speeckaert@ugent.be.
authors.forename: Marijn M
authors.initials: MM
authors.lastname: Speeckaert
mesh_terms: D000818:Animals; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D007668:Kidney / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D016030:Kidney Transplantation / Q000379:methods; D008264:Macrophages / Q000473:pathology
chemical_list: D020381:Interleukin-17
keywords: Interleukin-17A; inflammation; kidney disease