title: Ex-vivo lung perfusion: the model for the organ reconditioning hub.
abstract: OBJECTIVE
  Lung evaluation and reconditioning by ex-vivo lung perfusion (EVLP) is becoming increasingly established. We review strategies for broader implementation of this technology to transplant centers worldwide.
  
  
  RESULTS
  The organ reconditioning hub model is a viable strategy for disseminating EVLP to small and large transplant centers given the well tolerated prolongation of preservation time afforded by EVLP. Regulatory and process issues remain hurdles to be overcome.
  
  
  CONCLUSIONS
  EVLP demonstrates promise to increase lung utilization. Organ reconditioning hubs appear to be an efficient method of delivering this promise to all transplant centers, not necessarily only the largest ones. Organ allocation processes will need to adapt to this new paradigm of organ preservation and evaluation. Moreover, regulatory issues will need to be deliberated by the transplant community.
authors.affiliation: Division of Thoracic Surgery, Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Yeung
authors.forename: Marcelo
authors.initials: M
authors.lastname: Cypel
authors.forename: Shaf
authors.initials: S
authors.lastname: Keshavjee
mesh_terms: D005112:Extracorporeal Circulation / Q000379:methods*; D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion / Q000379:methods*; D009927:Tissue and Organ Procurement / Q000379:methods*