title: In vivo bioactivity of porous polyetheretherketone with a foamed surface.
abstract: The in vivo bioactivity of porous polyetheretherketone (PEEK) with a foamed surface was evaluated using rabbit femoral bone. Cylindrical porous PEEK scaffolds, with pore diameter of 550 μm and porosity of 70%, were first prepared and immersed in 98% sulfuric acid, and then washed and immersed in 3 M potassium carbonate solution used as a foaming reagent. Numerous open pores of various sizes, as well as new functional groups, were visualized on the treated PEEK surface by scanning electron microscopy and X-ray photoelectron spectroscopy, respectively. Micro computed tomography (micro-CT) showed that the volumetric density of treated PEEK was higher than that of bare PEEK at 8 weeks after surgery (p<0.05). Additionally, von Kossa staining indicated ingrowth of mature new bone tissue at 4 weeks relative to the bare PEEK group. Our data indicate that surface-treated PEEK exhibited improved bioactivity in vivo.
authors.affiliation: Department of Oral Implantology, Osaka Dental University.
authors.forename: Ayato
authors.initials: A
authors.lastname: Hieda
authors.forename: Naoya
authors.initials: N
authors.lastname: Uemura
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Isumi
authors.initials: I
authors.lastname: Toda
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Baba
mesh_terms: D000818:Animals; D001577:Benzophenones; D001842:Bone and Bones; D007659:Ketones; D008422:Materials Testing; D056951:Photoelectron Spectroscopy; D011092:Polyethylene Glycols; D011108:Polymers; D016062:Porosity; D011817:Rabbits; D055114:X-Ray Microtomography
chemical_list: D001577:Benzophenones; D007659:Ketones; D011108:Polymers; C063834:polyetheretherketone; D011092:Polyethylene Glycols