title: Monitoring daily intraocular pressure fluctuations with self-tonometry in healthy subjects.
abstract: OBJECTIVE
  To evaluate the accuracy of the intraocular pressure (IOP) measured by healthy subjects with icare®Home and to observe the IOP fluctuation and pattern of IOP fluctuation in healthy subjects over three consecutive days.
  
  
  METHODS
  Sixty healthy subjects were recruited to the study. IOP was measured by the subjects themselves and by study staff using icare®Home tonometers on visits 1 and 2, as well as by study staff using Goldmann applanation tonometry (GAT). Furthermore, the subjects measured their IOP at home for three consecutive days.
  
  
  RESULTS
  Twenty-three per cent of the study eyes were excluded in the statistical analysis due to dropout or non-compliance to the schedule. Approximately 70% of the icare®Home measurements were within 3 mmHg of the GAT measurements. Ten to 16% of the study eyes had IOP peaks outside office hours. Sixty-three per cent of the study eyes had different IOP patterns on consecutive days.
  
  
  CONCLUSIONS
  Rebound self-tonometry appears to be accurate and could be used to monitor short- and long-term IOP variations. The difference between IOP patterns on consecutive days raises questions as to the certainty of a single IOP measurement as a measure of treatment effect.
authors.affiliation: Department of Clinical Neurosciences, Department of Anterior Segment Disorders, Glaucoma, Neuro-Ophthalmology and Oculoplastics (Clinic 1), St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Laurence
authors.initials: L
authors.lastname: Quérat
authors.affiliation: Department of Clinical Neurosciences, Department of Anterior Segment Disorders, Glaucoma, Neuro-Ophthalmology and Oculoplastics (Clinic 1), St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Enping
authors.initials: E
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000503:physiopathology; D064368:Healthy Volunteers; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D011446:Prospective Studies; D015203:Reproducibility of Results; D014065:Tonometry, Ocular / Q000379:methods*; D055815:Young Adult
keywords: IOP fluctuations; healthy subjects; iCare® Home; pattern of IOP fluctuations; rebound self-tonometry