title: Inflammatory status and uricaemia determine HDL-cholesterol levels in hypertensive adults over 65: an analysis of the FAPRES register.
abstract: In inflammatory disease, the levels of high-density lipoprotein cholesterol (HDL-C) decrease, and the composition of HLD-C changes. Data from the "non-inflammatory" general population indicate the presence of the same phenomenon, albeit to a smaller extent. Levels of uricaemia contribute to the overall inflammatory state of patients. The aim of this study was to analyse the association between inflammatory state, levels of uricaemia, and levels of HLD-C in a hypertensive Spanish population aged 65 or older. This was a retrospective analysis of the FAPRES database. We compared lipid levels [HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides] in terciles of patients according to their leukocyte counts and uricaemia. When we observed statistically significant differences at a 95% confidence level, we constructed a multivariable linear regression model to adjust for possible confounders. We analysed 860 patients (52.7% women) with a mean age of 72.9 years (±5.8). Participants in the highest tercile for leukocytes or uricaemia presented with significantly lower levels of HDL-C and higher levels of triglycerides, but there was no difference in total cholesterol or LDL-C. The multivariable analysis confirmed an independent and inverse association between HDL-C and both leukocytes (β = -0.001, p = 0.025) and uricaemia (β = -1.054, p = 0037) as well as an independent, direct association between triglycerides and both leukocytes (β = 0.004, p = 0.049), and uricaemia (β = 8.411, p = 0.003). In hypertensive adults aged 65 or older, inflammatory state, and uricaemia independently operate to decrease HDL-C-these findings confirm those described in studies in people with inflammatory disease. This phenomenon could help to define a proatherogenic profile in people without inflammatory disease.
authors.affiliation: Cardiology Service, General University Hospital of Elche, Camí de l'Almazara 11, 03203, Elche (Alicante), Spain. mariamteati@hotmail.com.
authors.forename: María Amparo
authors.initials: MA
authors.lastname: Quintanilla
authors.affiliation: Rheumatology Unit, General University Hospital of Alicante, Alicante, Spain.|Department of Clinical Medicine, Universidad Miguel Hernández, Alicante, Spain.
authors.forename: Mariano
authors.identifier: http://orcid.org/0000-0002-0219-9055
authors.initials: M
authors.lastname: Andrés
authors.affiliation: Rheumatology Unit, General University Hospital of Alicante, Alicante, Spain.|Department of Clinical Medicine, Universidad Miguel Hernández, Alicante, Spain.
authors.forename: Eliseo
authors.initials: E
authors.lastname: Pascual
authors.affiliation: Unidad de Vigilancia de la Salud, Unión de Mutuas, Castellón, Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Pallarés
authors.affiliation: Servicio de Cardiología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Fácila
authors.affiliation: Cardiology Service, General University Hospital of Elche, Camí de l'Almazara 11, 03203, Elche (Alicante), Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Morillas
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D033461:Hyperuricemia / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D007958:Leukocyte Count; D007962:Leukocytes; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D014527:Uric Acid
keywords: Cholesterol levels; Inflammation; Leukocytes count; Serum uric acid