title: Linking hepatitis C virus infection to pre-1994 blood transfusions in female patients.
abstract: Most blood transfusions occur in female patients. The introduction of serologic screening practices by blood banks reduced the transfusion-related rate of infection with hepatitis C virus (HCV). In Mexico patients with pre-1994 transfusion history are at high risk of being detected with HCV infection. We aimed at establishing an interrelationship between two variables: pre-1994 transfusion history and rate of infection in women treated in the Guadalajara Metropolitan Area hospitals, in Mexico.
  
  
  
  Analytical observational case-control study which included both non-infected women and patients diagnosed with hepatitis C virus infection, in whom the pre-1994 transfusion history was determined. The cases were 150 women with confirmed hepatitis C virus serologic diagnosis. The controls were 150 women whose hepatitis C virus-detection serologic tests had yielded negative results.
  
  
  
  An odds ratio of 9.07 (95% CI: 5.37 – 15.3; p< 0.001) was found where the rate of infection for the case group was 0.72 while the control group had a ratio of 0.22; population attributable risk (PAR) was 0.64 (95% CI: 0.53 – 0.73), while etiologic fraction was 0.88 (95% CI: 0.81 – 0.93).
  
  
  
  Among women, having been exposed to pre-1994 blood transfusion means a risk 9.07 times higher than not being exposed to blood transfusion in the same time frame.
authors.affiliation: Departamento de Epidemiología, Unidad de Medicina Familiar 168, Instituto Mexicano del Seguro Social, Tepatitlán, Jalisco, México. Address: Avenida Patria 3000, Edificio 23, Departamento 6, Colonia Lagos del Country, Zapopan, Jalisco, México. Email: hugo_ramos@ucol.mx.
authors.forename: Christian
authors.initials: C
authors.lastname: Ramos Flores
authors.affiliation: Departamento de Infectología, Centro Médico Nacional de Occidente, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Guadalajara Jalisco, México.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Echeagaray
authors.affiliation: Coordinación de Información y Análisis Estratégico, Jefatura de Servicios de Prestaciones Médicas, Instituto Mexicano del Seguro Social, Guadalajara Jalisco, México.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Castañeda
authors.affiliation: Banco de Sangre Central, Centro Médico Nacional de Occidente, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Guadalajara Jalisco, México.
authors.forename: Maria de Lourdes
authors.initials: ML
authors.lastname: Vargas
authors.affiliation: Banco de Sangre Central, Centro Médico Nacional de Occidente, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Guadalajara Jalisco, México.
authors.forename: Raúl
authors.initials: R
authors.lastname: Montes-González
authors.affiliation: Hospital de Ginecoobstetricia, Centro Médico Nacional de Occidente, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Guadalajara Jalisco, México.
authors.forename: Susana
authors.initials: S
authors.lastname: Luna
authors.affiliation: Hospital de Ginecoobstetricia, Centro Médico Nacional de Occidente, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Guadalajara Jalisco, México.
authors.forename: Laura
authors.initials: L
authors.lastname: Díaz
authors.affiliation: Banco de Sangre Central, Centro Médico Nacional de Occidente, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Guadalajara Jalisco, México.
authors.forename: Oscar
authors.initials: O
authors.lastname: Torres
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification*; D006526:Hepatitis C / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D012698:Serologic Tests / Q000379:methods*; D013997:Time Factors; D065227:Transfusion Reaction
keywords:  blood transfusion;  hepatitis C; risk factors