title: N-Pyrrylarylsulfones with High Therapeutic Potential.
abstract: This review illustrates the various studies made to investigate the activity ofN-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure-activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential ofN-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of newN-pyrrylarylsulfone based agents.
authors.affiliation: Department of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, I-00185 Roma, Italy. valeria.famiglini@uniroma1.it.
authors.forename: Valeria
authors.initials: V
authors.lastname: Famiglini
authors.affiliation: Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I-84084 Fiscano, Salerno, Italy. scastellano@unisa.it.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Castellano
authors.affiliation: Department of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, I-00185 Roma, Italy. romano.silvestri@uniroma1.it.
authors.forename: Romano
authors.initials: R
authors.lastname: Silvestri
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D013449:Sulfonamides
keywords: heterocycle; polycyclic compound; sulfonamide; therapeutic agent