title: Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme.
abstract: Artificial enzymes are required to catalyse non-natural reactions. Here, a hybrid catalyst was developed by embedding a novel Ru complex in the transport protein NikA. The protein scaffold activates the bound Ru complex to produce a catalyst with high regio- and stereo-selectivity. The hybrid efficiently and stably produced α-hydroxy-β-chloro chlorohydrins from alkenes (up to 180 TON with a TOF of 1050 h-1).
authors.affiliation: Université Grenoble Alpes, Laboratoire de Chimie et Biologie des Métaux, BioCE, F-Grenoble, France and CNRS, Laboratoire de Chimie et Biologie des Métaux, BioCat, UMR 5249, France and CEA-Grenoble, DRF/BIG/CBM, F-Grenoble, France. stephane.menage@cea.fr.
authors.forename: Sarah
authors.initials: S
authors.lastname: Lopez
authors.affiliation: Université Grenoble Alpes, Laboratoire de Chimie et Biologie des Métaux, BioCE, F-Grenoble, France and CNRS, Laboratoire de Chimie et Biologie des Métaux, BioCat, UMR 5249, France and CEA-Grenoble, DRF/BIG/CBM, F-Grenoble, France. stephane.menage@cea.fr.
authors.forename: Laurianne
authors.initials: L
authors.lastname: Rondot
authors.affiliation: Université Grenoble Alpes, Laboratoire de Chimie et Biologie des Métaux, BioCE, F-Grenoble, France and CNRS, Laboratoire de Chimie et Biologie des Métaux, BioCat, UMR 5249, France and CEA-Grenoble, DRF/BIG/CBM, F-Grenoble, France. stephane.menage@cea.fr.
authors.forename: Christine
authors.initials: C
authors.lastname: Cavazza
authors.affiliation: Université Grenoble Alpes, Laboratoire de Chimie et Biologie des Métaux, BioCE, F-Grenoble, France and CNRS, Laboratoire de Chimie et Biologie des Métaux, BioCat, UMR 5249, France and CEA-Grenoble, DRF/BIG/CBM, F-Grenoble, France. stephane.menage@cea.fr.
authors.forename: Marina
authors.initials: M
authors.lastname: Iannello
authors.affiliation: Université Grenoble Alpes, Laboratoire de Chimie et Biologie des Métaux, BioCE, F-Grenoble, France and CNRS, UMR CEA, IBS, F-38044 Grenoble, France.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Boeri-Erba
authors.affiliation: Inorganic Chemistry, Department of Chemistry and Pharmacy & Interdisciplinary Center for Molecular Materials (ICMM), University of Erlangen-Nuremberg, Egerlandstraße 1, 91058 Erlangen, Germany.
authors.forename: Nicolai
authors.identifier: http://orcid.org/0000-0001-9063-555X
authors.initials: N
authors.lastname: Burzlaff
authors.affiliation: Inorganic Chemistry, Department of Chemistry and Pharmacy & Interdisciplinary Center for Molecular Materials (ICMM), University of Erlangen-Nuremberg, Egerlandstraße 1, 91058 Erlangen, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Strinitz
authors.affiliation: Université Grenoble Alpes, Laboratoire de Chimie et Biologie des Métaux, BioCE, F-Grenoble, France and CNRS, Laboratoire de Chimie et Biologie des Métaux, BioCat, UMR 5249, France and CEA-Grenoble, DRF/BIG/CBM, F-Grenoble, France. stephane.menage@cea.fr.
authors.forename: Adeline
authors.initials: A
authors.lastname: Jorge-Robin
authors.affiliation: Université Grenoble Alpes, Laboratoire de Chimie et Biologie des Métaux, BioCE, F-Grenoble, France and CNRS, Laboratoire de Chimie et Biologie des Métaux, BioCat, UMR 5249, France and CEA-Grenoble, DRF/BIG/CBM, F-Grenoble, France. stephane.menage@cea.fr.
authors.forename: Caroline
authors.initials: C
authors.lastname: Marchi-Delapierre
authors.affiliation: Université Grenoble Alpes, Laboratoire de Chimie et Biologie des Métaux, BioCE, F-Grenoble, France and CNRS, Laboratoire de Chimie et Biologie des Métaux, BioCat, UMR 5249, France and CEA-Grenoble, DRF/BIG/CBM, F-Grenoble, France. stephane.menage@cea.fr.
authors.forename: Stéphane
authors.identifier: http://orcid.org/0000-0003-4512-8836
authors.initials: S
authors.lastname: Ménage
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D002728:Chlorohydrins / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry; D008968:Molecular Conformation; D012428:Ruthenium / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D002728:Chlorohydrins; D056831:Coordination Complexes; D012428:Ruthenium