title: Four new bi-2-(2-phenylethyl)chromone derivatives of agarwood from Aquilaria crassna.
abstract: Four new bi-2-(2-phenylethyl)chromone derivatives, crassins A-D (1-4), were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna. The structures including the absolute configurations of compounds were unambiguously elucidated by extensive spectroscopic methods (1D and 2D NMR, UV, ECD, IR, MS), and by comparison with the literature. The isolated compounds were tested for their acetylcholinesterase (AChE) and α-glucosidase inhibitory activities, as well as cytotoxic activities. All the compounds showed weak inhibitory activity against AChE, while compounds 3 and 4 also displayed weak cytotoxicity against human myeloid leukemia cell line (K562).
authors.affiliation: College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
authors.forename: Fan-Dong
authors.initials: FD
authors.lastname: Kong
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
authors.forename: Hui-Qin
authors.initials: HQ
authors.lastname: Chen
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China. Electronic address: chenzhibao_2000@sina.com.
authors.forename: Zhi-Bao
authors.initials: ZB
authors.lastname: Chen
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. Electronic address: daihaofu@itbb.org.cn.
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D000110:Acetylcholinesterase; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D065089:Glycoside Hydrolase Inhibitors / Q000302:isolation & purification; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D029645:Thymelaeaceae / Q000737:chemistry*; D014934:Wood / Q000737:chemistry*; D000520:alpha-Glucosidases
chemical_list: D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; C062550:2-(2-phenylethyl)chromone; D000110:Acetylcholinesterase; D000520:alpha-Glucosidases
keywords: Agarwood; Aquilaria crassna; Bi-2-(2-phenylethyl)chromone; Biological activity