title: Cancer antigen-125 plasma level as a biomarker of new-onset atrial fibrillation in postmenopausal women.
abstract: Plasma cancer antigen (CA)-125 is a tumour marker recently shown to be associated with systolic heart failure and new-onset atrial fibrillation (AF) after myocardial infarction. However, no reports have described the relationship between CA-125 and new-onset AF in healthy postmenopausal women. The aim of the present study was to evaluate the relationship between CA-125 and new-onset AF in postmenopausal women.
  
  
  
  Between 2005 and 2015, 2086 women, including 1012 postmenopausal women, visited our hospital for annual health check-ups. We excluded patients with systolic dysfunction, chronic inflammatory disease, chronic obstructive pulmonary disease, histories of AF or neoplastic diseases. A total of 746 postmenopausal women underwent thorough physical examinations, including those for biomarkers such as brain natriuretic peptide, high-sensitivity C-reactive protein (hs-CRP) and CA-125.
  
  
  
  During the 10-year observation period, AF was documented in 31 participants (4.2%). The mean age of participants developing AF (75±6 years) was higher than that of those without AF (68±8 years). Participants developing AF showed significantly higher CA-125 (11.4±6.3 U/mL) and hs-CRP (0.10±0.11 mg/dL) levels than did those without AF (7.7±3.2 U/mL, p<0.01; 0.07±0.08 mg/dL, p<0.05). Cox regression analyses revealed ageing (HR 1.3; 95% CI 1.08 to 1.57; p<0.01) and plasma CA-125 levels (HR 1.29; 95% CI 1.10 to 1.51; p=0.02) as independent predictors of AF.
  
  
  
  High CA-125 levels might be associated with new-onset AF in healthy postmenopausal women.
authors.affiliation: Cardiology, Aoyama Hospital, Tokyo Women's Medical University, Tokyo, Japan.|Cardiology, National Hospital Organization Yokohama Medical Center, Kanagawa, Japan.|Cardiology, Tokyo Women's Medical University, Tokyo, Japan.|Cardiology, Institute of Geriatrics Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Sekiguchi
authors.affiliation: Cardiology, Aoyama Hospital, Tokyo Women's Medical University, Tokyo, Japan.|Cardiology, Tokyo Women's Medical University, Tokyo, Japan.|General Medicine, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Shimamoto
authors.affiliation: Cardiology, Aoyama Hospital, Tokyo Women's Medical University, Tokyo, Japan.|Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Mayu
authors.initials: M
authors.lastname: Takano
authors.affiliation: Cardiology, Aoyama Hospital, Tokyo Women's Medical University, Tokyo, Japan.|Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Kimura
authors.affiliation: Cardiology, Aoyama Hospital, Tokyo Women's Medical University, Tokyo, Japan.|Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Yufuko
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Cardiology, Aoyama Hospital, Tokyo Women's Medical University, Tokyo, Japan.|Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Fujio
authors.initials: F
authors.lastname: Tatsumi
authors.affiliation: Cardiology, Aoyama Hospital, Tokyo Women's Medical University, Tokyo, Japan.|Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Watanabe
authors.affiliation: Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Jujo
authors.affiliation: Cardiology, Tokyo Women's Medical University, Tokyo, Japan.|Cardiology, Institute of Geriatrics Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Ishizuka
authors.affiliation: Cardiology, Aoyama Hospital, Tokyo Women's Medical University, Tokyo, Japan.|Cardiology, Tokyo Women's Medical University, Tokyo, Japan.|General Medicine, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kawana
authors.affiliation: Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Hagiwara
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications*; D017698:Postmenopause; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen
keywords: Atrial Fibrillation; Epidemiology; Inflammatory markers