title: Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China: Guangzhou Birth Cohort Study.
abstract: Prior investigations on the associations of polyfluoroalkyl substances (PFASs) with fetal growth are mixed. Moreover, little research has accrued pertaining to the association between isomers of PFASs with gestational age and birth weight. To address this gap and present novel information, we conducted a study including 321 pairs of mothers and their infants recruited from Guangzhou, China. High performance liquid chromatography-mass spectrometry was utilized to analyze isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) along with other PFAS levels in cord serum samples. Mothers' and infants' characteristics were gathered from medical records. The resulting data revealed that higher PFOS, PFOA and isomers of PFOS were associated with lower birth weight. Per ln-unit (ng/mL) increase in cord serum total branched PFOS isomers was associated with a 126.3g (95% CI: -195.9, -56.8) reduction in the weight of infants at birth, while an ln-unit (ng/mL) increase of serum linear PFOS isomers (n-PFOS) was associated with a 57.2g (95% CI: -103.1, -11.3) reduction in the weight of infants at birth upon the subsequent adjustment for potential confounding variables. Notably, the association between cord PFAS level and birth weight was more pronounced in male infants. Furthermore, a positive association among branched PFOS isomers (1m-PFOS and 3+4+5m-PFOS) and gestational age was found. No associations could be found among other PFASs in conjunction with gestational age or birth weight. In conclusion, this investigation suggests that higher PFAS concentrations are associated with lower birth weight, and branched PFOS isomers show greater impact on infant birth weight than linear PFOS.
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Zeng
authors.affiliation: Department of Epidemiology, College for Public Health and Social Justice, Saint Louis University, Saint Louis 63104, USA.
authors.forename: Zhengmin Min
authors.initials: ZM
authors.lastname: Qian
authors.affiliation: School of Social Work, College for Public Health and Social Justice, Saint Louis University, Saint Louis 63104, USA.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Vaughn
authors.affiliation: Department of Chemistry, Université de Montréal, Montreal, QC H3C 3J7, Canada.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Sauvé
authors.affiliation: Faculty of Health, School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
authors.forename: Gunther
authors.initials: G
authors.lastname: Paul
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, State University of New York, Albany, NY 12144-3445, USA.
authors.forename: Shao
authors.initials: S
authors.lastname: Lin
authors.affiliation: Liwan District Maternal and Child Health Hospital, Guangzhou 510375, China.
authors.forename: Long
authors.initials: L
authors.lastname: Lu
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Hu
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Bo-Yi
authors.initials: BY
authors.lastname: Yang
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Xiao-Di
authors.initials: XD
authors.lastname: Qin
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: Xu
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Bao
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Ya-Zhi
authors.initials: YZ
authors.lastname: Zhang
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yuan
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Yan-Peng
authors.initials: YP
authors.lastname: Tian
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Min
authors.initials: M
authors.lastname: Nian
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou 310053, China; Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China. Electronic address: fucx@gzcdc.org.cn.
authors.forename: Chuanxi
authors.initials: C
authors.lastname: Fu
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: donggh5@mail.sysu.edu.cn.
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Dong
mesh_terms: D000328:Adult; D017738:Alkanesulfonic Acids / Q000097:blood* / Q000737:chemistry / Q000633:toxicity; D001724:Birth Weight / Q000187:drug effects*; D002681:China; D002851:Chromatography, High Pressure Liquid; D015331:Cohort Studies; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood* / Q000737:chemistry / Q000633:toxicity; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D047109:Fetal Development / Q000187:drug effects; D005466:Fluorocarbons / Q000097:blood* / Q000737:chemistry / Q000633:toxicity; D005865:Gestational Age; D006801:Humans; D007536:Isomerism; D008297:Male; D008499:Medical Records; D012737:Sex Factors
chemical_list: D017738:Alkanesulfonic Acids; D004785:Environmental Pollutants; D005466:Fluorocarbons; C076994:perfluorooctane sulfonic acid
keywords: Birth weight; Gestational age; Isomers; Polyfluoroalkyl substances (PFASs)