title: Two possible modes of pioneering associated with combinations of H2A.Z and p300/CBP at nucleosome-occupied enhancers.
abstract: Pioneer transcription factors are defined by their ability to bind nucleosome-occupied regions. Here, we discuss the properties of nucleosomes bound by pioneers at enhancer regions. We describe how select pioneers bind nucleosome-occupied or -depleted enhancer sites. Importantly, by revisiting and expanding existing data sets, we show differential H2A.Z and p300/CBP association at bound enhancers, highlighting two possible pioneering modes.
authors.affiliation: a Max Planck Institute of Immunobiology and Epigenetics , Department of Cellular and Molecular Immunology , Freiburg im Breisgau , Germany.
authors.forename: Pierre
authors.identifier: 0000-0002-0659-0799
authors.initials: P
authors.lastname: Cauchy
authors.affiliation: b Max Planck Institute for Molecular Genetics , Department of Developmental Genetics , Berlin , Germany.
authors.forename: Frederic
authors.initials: F
authors.lastname: Koch
authors.affiliation: c Institut de Génétique Moléculaire de Montpellier, CNRS UMR5535 , Montpellier , France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Andrau
mesh_terms: D000818:Animals; D004742:Enhancer Elements, Genetic / Q000502:physiology*; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009707:Nucleosomes / Q000235:genetics / Q000378:metabolism*; D050880:p300-CBP Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D006657:Histones; D009707:Nucleosomes; C077020:histone H2A.F-Z; D050880:p300-CBP Transcription Factors
keywords: H2A.Z; MNase-Seq; labile; nucleosome; p300/CBP; transcription factor