title: Does the serum uric acid level have any relation to arterial stiffness or blood pressure in adults with congenital renal agenesis and/or hypoplasia?
abstract: BACKGROUND
  The relationship between serum uric acid and arterial stiffness or blood pressure is not clear. The serum uric acid level and its association with cardiovascular risk is not well known in patients with reduced renal mass. We aimed to investigate the relation between serum uric acid levels and arterial stiffness and also blood pressure in patients with congenital renal agenesis and/or hypoplasia.
  
  
  METHODS
  In this single center, cross-sectional study, a total of 55 patients (39 (% 70.9) with unilateral small kidney and 16 (%29.1) with renal agenesis) were included. The median age was 35 (21-50) years. The study population was divided into tertiles of serum uric acid (according to 2.40-3.96, 3.97-5.10, and 5.11-9.80 mg/dl cut-off values of serum uric acid levels). Official and 24-h ambulatory non-invasive blood pressures of all patients were measured. The arterial stiffness was assessed by pulse wave velocity (PWV).
  
  
  RESULTS
  PWV values were increased from first to third tertile (5.5 ± 0.6, 5.7 ± 0.8, 6.1 ± 0.7, respectively), but this gradual increase between tertiles did not reach significance. Linear regression analyses showed a positive correlation between serum uric acid levels and PWV (β = 0.40, p = 0.010), but no correlation was found between uric acid and daytime systolic blood pressure (β = 0.24, p = 0.345).
  
  
  CONCLUSIONS
  In congenital renal agenesis/hypoplasia, the serum uric acid level was positively correlated with arterial stiffness, but there was no correlation with blood pressure.
authors.affiliation: a Konya Education and Research Hospital , Department of Nephrology , Konya , Turkey.
authors.forename: Raziye
authors.initials: R
authors.lastname: Yazici
authors.affiliation: a Konya Education and Research Hospital , Department of Nephrology , Konya , Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Guney
authors.affiliation: a Konya Education and Research Hospital , Department of Nephrology , Konya , Turkey.
authors.forename: Lutfullah
authors.initials: L
authors.lastname: Altintepe
authors.affiliation: b Necmettin Erbakan University , Meram Medical School, Department of Cardiology , Konya , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yazici
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001795:Blood Pressure Determination; D002318:Cardiovascular Diseases; D000013:Congenital Abnormalities / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D007668:Kidney / Q000002:abnormalities*; D007674:Kidney Diseases / Q000097:blood / Q000151:congenital*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*; D059289:Vascular Stiffness; D055815:Young Adult
chemical_list: D014527:Uric Acid
keywords: Arterial stiffness; hypoplastic kidney; pulse wave velocity; renal agenesia; uric acid