title: Perinatal risk factors in newborns with gastrointestinal perforation.
abstract: OBJECTIVE
  To investigate correlation of perinatal risk factors in newborns with gastrointestinal perforation (GIP).
  
  
  METHODS
  Single-center retrospective cohort study was conducted between January 1990 and December 2012. Medical records on all newborns with GIP were reviewed (n= 35). Surgical records and histopathologic examination of all perforated intestine samples were also reviewed.
  
  
  RESULTS
  The most common cause of GIP was necrotizing enterocolitis (51.4%). The most common site of perforation was large intestine. Mortality rate was 31%. Infants with GIP more frequently had very low birth weight (< 1500 g), especially birth weight below 10thpercentile according to gestational age. Ponderal index was not differing between infants with GIP and control subjects. In infants with GIP anemia was more frequently found than in control group.
  
  
  CONCLUSIONS
  GIP in newborns is mostly disease of infants with birth weight below 10thpercentile according to gestational age. GIP occurs more often in infants with anemia.
authors.affiliation: Sandra Prgomet, Adela Arapović, Department of Pediatrics, University Hospital of Split and University of Split, School of Medicine, 21000 Split, Croatia.
authors.forename: Sandra
authors.initials: S
authors.lastname: Prgomet
authors.affiliation: Sandra Prgomet, Adela Arapović, Department of Pediatrics, University Hospital of Split and University of Split, School of Medicine, 21000 Split, Croatia.
authors.forename: Boris
authors.initials: B
authors.lastname: Lukšić
authors.affiliation: Sandra Prgomet, Adela Arapović, Department of Pediatrics, University Hospital of Split and University of Split, School of Medicine, 21000 Split, Croatia.
authors.forename: Zenon
authors.initials: Z
authors.lastname: Pogorelić
authors.affiliation: Sandra Prgomet, Adela Arapović, Department of Pediatrics, University Hospital of Split and University of Split, School of Medicine, 21000 Split, Croatia.
authors.forename: Ivo
authors.initials: I
authors.lastname: Jurić
authors.affiliation: Sandra Prgomet, Adela Arapović, Department of Pediatrics, University Hospital of Split and University of Split, School of Medicine, 21000 Split, Croatia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Čapkun
authors.affiliation: Sandra Prgomet, Adela Arapović, Department of Pediatrics, University Hospital of Split and University of Split, School of Medicine, 21000 Split, Croatia.
authors.forename: Adela
authors.initials: A
authors.lastname: Arapović
authors.affiliation: Sandra Prgomet, Adela Arapović, Department of Pediatrics, University Hospital of Split and University of Split, School of Medicine, 21000 Split, Croatia.
authors.forename: Nataša
authors.initials: N
authors.lastname: Boban
keywords: Gastrointestinal perforation; Necrotizing enterocolitis; Newborn; Ponderal index