title: Comparison of Two Swiss-Designed Hyaluronic Acid Gels: Six-Month Clinical Follow-Up.
abstract: The aim of this paper is to compare 2 hyaluronic acid gel fillers from the same Swiss manufacturer and with the same indications: filling of line wrinkles and folds. The products differ by their cross-linking process. With very simple easy-to-reproduce tests, cohesivity and resistance to traction forces were examined. Also, both gels were injected under ultrasound control in the mid reticular dermis of three subjects. The papules were controlled under ultrasound and biopsies at D0 and D15. Results showed significant differences between the 2 gels in all the tests. The new gel, manufactured with a lower-crosslinking density, seems to benefit from better integration in the tissue of the mid reticular dermis and to have a more cohesive nature than its comparator from a previous crosslinking technology. Under clinical observation, the range of new products present excellent tissue integration properties. <p><em>J Drugs Dermatol. 2017;16(2):154-161.</em></p>.
authors.forename: Patrick
authors.initials: P
authors.lastname: Micheels
authors.forename: Didier
authors.initials: D
authors.lastname: Sarazin
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Besse
authors.forename: Badwi
authors.initials: B
authors.lastname: Eliasd
mesh_terms: D000368:Aged; D003357:Cosmetic Techniques; D004339:Drug Compounding; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry / Q000627:therapeutic use*; D008875:Middle Aged; D015595:Skin Aging; D013499:Surface Properties; D013557:Switzerland
chemical_list: D005782:Gels; D006820:Hyaluronic Acid