title: Milestone clinical trials of the National Surgical Adjuvant Breast and Bowel Project (NSABP).
abstract: The National Surgical Adjuvant Breast and Bowel Project (NSABP) has made significant contributions in reducing the extent of breast surgery and in improving outcomes of patients with early-stage breast cancer through the conduct of large randomized clinical trials evaluating local and systemic therapy. In 2014, the NSABP merged with two other US National Cancer Institute-funded cooperative groups, the Radiation Therapy Oncology Group (RTOG) and the Gynecologic Oncology Group (GOG), to form NRG Oncology. The combined organization has 218 member institutions with more than 600 affiliate centers located throughout the United States, Canada, Puerto Rico, and other international sites. Over the past half century, the NSABP has entered more than 150,000 women into clinical trials of breast cancer treatment and breast cancer prevention. Many of these trials have been instrumental in establishing new standards of care for patients with breast cancer.
authors.affiliation: National Surgical Adjuvant Breast and Bowel Project (NSABP), Pittsburgh, PA, USA; University of Pittsburgh Cancer Institute School of Medicine, Pittsburgh, PA, USA. priya.rastogi@nsabp.org.
authors.forename: Priya
authors.initials: P
authors.lastname: Rastogi
authors.affiliation: National Surgical Adjuvant Breast and Bowel Project (NSABP), Pittsburgh, PA, USA; Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
authors.forename: D Lawrence
authors.initials: DL
authors.lastname: Wickerham
authors.affiliation: National Surgical Adjuvant Breast and Bowel Project (NSABP), Pittsburgh, PA, USA; Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, USA.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Geyer
authors.affiliation: National Surgical Adjuvant Breast and Bowel Project (NSABP), Pittsburgh, PA, USA; UF Health Cancer Center at Orland Health, Orlando, FL, USA.
authors.forename: Eleftherios P
authors.initials: EP
authors.lastname: Mamounas
authors.affiliation: National Surgical Adjuvant Breast and Bowel Project (NSABP), Pittsburgh, PA, USA; Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Julian
authors.affiliation: National Surgical Adjuvant Breast and Bowel Project (NSABP), Pittsburgh, PA, USA; Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
authors.forename: Norman
authors.initials: N
authors.lastname: Wolmark
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000628:therapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy; D017024:Chemotherapy, Adjuvant / Q000379:methods; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008408:Mastectomy; D020360:Neoadjuvant Therapy; D012955:Societies, Medical; D014015:Tissue Banks
keywords: Breast cancer; clinical trials; locoregional therapy for breast cancer; systemic therapy for breast cancer