title: [Analysis of short-term respiratory adverse events in 183 bronchial thermoplasty procedures].
abstract: Objective:To analyze the short-term (3 weeks) adverse respiratory events after bronchial thermoplasty(BT) in patients with severe asthma.Methods:The China-Japan Friendship Hospital recruited 62 patients with severe asthma for BT treatment from March 2014 to July 2016, with a total of 183 BT procedures. The data of adverse respiratory events within 3 weeks after procedure were collected to analyze the factors that might potentially influence the occurrence of adverse events.Results:Forty-three patients (69.4%) experienced adverse respiratory events within 3 weeks after treatment. Totally 153 adverse respiratory events occurred after 87 procedures(47.5%). The main adverse events were cough (15 events, 8.20%), sputum production (37 events, 20.22%), temporary PEF reduction (37 events, 20.22%), chest distress (12 events, 6.56%), blood in sputum (11 events, 6.01%), asthma exacerbation (10 events, 5.46%), and pneumonia(6 events, 3.28%). Most events were relieved or resolved with standard therapy in 1 week. No severe adverse events including tracheal intubation, malignant arrhythmias or death occurred within 3 weeks after procedure. The baseline eosinophil percentage in induced sputum and blood, operation times, and preoperative FEV(1) (% predicted) might influence the occurrence of adverse events after treatment. Patients with preoperative FEV(1) (% predicted) ≥60% had lower risk of adverse events.Conclusion:BT showed a good security profile in treating patients with severe asthma within 3 weeks after procedure.
authors.affiliation: Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Nong
authors.forename: J T
authors.initials: JT
authors.lastname: Lin
authors.forename: N
authors.initials: N
authors.lastname: Su
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: Q
authors.initials: Q
authors.lastname: Zhao
authors.forename: C Y
authors.initials: CY
authors.lastname: Han
authors.forename: R F
authors.initials: RF
authors.lastname: Qiu
mesh_terms: D000328:Adult; D001249:Asthma / Q000601:surgery*; D001980:Bronchi / Q000473:pathology / Q000601:surgery*; D002681:China; D003371:Cough / Q000150:complications*; D004599:Electric Stimulation Therapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D006979:Hyperthermia, Induced; D007958:Leukocyte Count; D008297:Male; D009130:Muscle, Smooth / Q000601:surgery*; D012129:Respiratory Function Tests; D013183:Sputum; D016896:Treatment Outcome
keywords: Adverse effects; Asthma; Bronchial thermoplasty; Therapeutics