title: Three dimensional approach to investigating biological effects along energetic ion beam pathways.
abstract: Heavy ion beams have many exciting applications, including radiotherapy of deep-seated tumors and simulation tests of space irradiation for astronauts. These beams often use a feature that concentrates the energy deposition largely along the end of the energy pathway, leading to different distributions of biological effects along the axial direction. Currently, there is relatively little information regarding the radial directional difference of biological effects along the heavy ion paths. This study utilized a filter membrane that was quantatively applied with cells to demonstrate a 3D distribution model of irradiation on biological effects in living organisms. Some results have indicated that there is excitatory effect on the non-irradiated regions with energetic ions, which may give new insights into the distribution of biological effects along the paths of heavy ion beams with mid-high energy.
authors.affiliation: Key Lab of Industrial Fermentation Microbiology (Tianjin University of Science and Technology), Ministry of Education, Tianjin, 300457, China.|College of Bioengineering, Tianjin University of Science and Technology, Tianjin, 300457, China.
authors.forename: Xinglin
authors.initials: X
authors.lastname: Li
authors.affiliation: Forestry College of Nanjing Forestry University, Nanjin, 210037, China.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Sun
authors.affiliation: Key Lab of Industrial Fermentation Microbiology (Tianjin University of Science and Technology), Ministry of Education, Tianjin, 300457, China.|College of Bioengineering, Tianjin University of Science and Technology, Tianjin, 300457, China.
authors.forename: Shanying
authors.initials: S
authors.lastname: Wang
authors.affiliation: Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
authors.forename: Wenjian
authors.initials: W
authors.lastname: Li
authors.affiliation: Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Qu
authors.affiliation: Hefei Jiushi Garden Construction Company, Hefei, 230000, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Cui
authors.affiliation: Forestry College, Anhui Agricultural University, Hefei, 230036, China.
authors.forename: Tianren
authors.initials: T
authors.lastname: Sun
authors.affiliation: Key Lab of Industrial Fermentation Microbiology (Tianjin University of Science and Technology), Ministry of Education, Tianjin, 300457, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
authors.forename: Jufang
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Radiological Medicine and Protection, School of Medicine, Suzhou University, Suzhou, 215123, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Key Lab of Industrial Fermentation Microbiology (Tianjin University of Science and Technology), Ministry of Education, Tianjin, 300457, China.|College of Bioengineering, Tianjin University of Science and Technology, Tianjin, 300457, China.
authors.forename: Shuli
authors.initials: S
authors.lastname: Man
authors.affiliation: Tianjin Academy of Education, Enrollment and Examination, Tianjin, 300060, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Key Lab of Industrial Fermentation Microbiology (Tianjin University of Science and Technology), Ministry of Education, Tianjin, 300457, China.|College of Bioengineering, Tianjin University of Science and Technology, Tianjin, 300457, China.
authors.forename: Fuping
authors.initials: F
authors.lastname: Lu
authors.affiliation: Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
authors.forename: Zengquan
authors.initials: Z
authors.lastname: Wei
authors.affiliation: Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
authors.forename: Genming
authors.initials: G
authors.lastname: Jin
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002708:Chlorella / Q000166:cytology / Q000528:radiation effects; D020450:Heavy Ions; D021621:Imaging, Three-Dimensional; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000528:radiation effects; D013481:Superoxides / Q000378:metabolism
chemical_list: D013481:Superoxides; D002244:Carbon