title: Catecholamine-Induced Chest Pain Mimicking Infarction Due to an MIBG-Negative and DOPA-Positive Succinate Dehydrogenase Syndrome Subunit B-Related Pheochromocytoma.
abstract: This 16-year-old boy presented with acute retrosternal pain possibly representing acute myocardial infarction. Cardiac enzymes were within reference ranges. There were marked increases in metanephrine to 3299 μg/24 h (reference, <400 μg/24 h), normetanephrine to 1309 μg/24 h (reference, 0-390 μg/24 h), and chromogranin A to 1605 ng/mL (reference, 0-150 μg/24 h). An incidental left adrenal mass was found during CTPA performed to exclude pulmonary embolism. I-MIBG scintigraphy was negative, and genetic screening detected SDHB (succinate dehydrogenase syndrome subunit B) gene mutation. Based on the gene mutation, F-DOPA PET/CT was performed, confirming a left-sided pheochromocytoma.
authors.affiliation: From the Departments of *Internal Medicine, and †Nuclear Medicine, Radiology, Neuroradiology, Medical Physics, Clinical Laboratory, Microbiology, Pathology, Molecular Biology, "Santa Maria della Misericordia" Hospital, Rovigo, Italy; and ‡Department of Radiology, University of Southern California, Los Angeles, CA.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mazza
authors.forename: Alice
authors.initials: A
authors.lastname: Ferretti
authors.forename: Antonella Paola
authors.initials: AP
authors.lastname: Sacco
authors.forename: Domenico
authors.initials: D
authors.lastname: Rubello
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Colletti
mesh_terms: D019797:3-Iodobenzylguanidine; D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000235:genetics; D002395:Catecholamines / Q000009:adverse effects*; D002637:Chest Pain / Q000139:chemically induced / Q000000981:diagnostic imaging*; D004295:Dihydroxyphenylalanine; D006801:Humans; D008297:Male; D009154:Mutation; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D010673:Pheochromocytoma / Q000150:complications* / Q000235:genetics; D000072078:Positron Emission Tomography Computed Tomography; D013385:Succinate Dehydrogenase / Q000235:genetics*
chemical_list: D002395:Catecholamines; D019797:3-Iodobenzylguanidine; D004295:Dihydroxyphenylalanine; D013385:Succinate Dehydrogenase