title: Serum Levels of Visfatin and Interleukin-6 in Non-Obese Versus Obese Men with Coronary Artery Disease.
abstract: To evaluate and compare the serum levels of visfatin, interleukin-6 and lipid profile in non-obese and obese male patients with coronary artery disease.
  
  
  
  Observational, comparative study.
  
  
  
  Punjab Institute of Cardiology and Lahore General Hospital, Lahore, from July to December 2013.
  
  
  
  The participants included 20 non-obese group I with coronary artery disease (CAD) and 20 obese males group II with coronary artery disease (angiographically confirmed). All the participants were in the age group of 35 - 55 years being non-smokers and non-diabetic. Serum visfatin and interleukin-6 levels were analysed by Enzyme Linked Immunosorbent Assay (ELISA). Lipid profile was also evaluated. Results were compared with T-test and Mann Whitney U test. The values were considered significant at 0.05 level of significance.
  
  
  
  Serum visfatin 9.05 versus 3.9 ng/ml and interleukin-6 12.80 versus 0.60 pg/ml levels were significantly (p-value < 0.001 of both) raised in the obese CAD group as compared to non-obese with CAD. Lipid profile also showed raised levels of total serum cholesterol, low density lipoproteins, triglycerides, very low density lipoproteins and low levels of high density lipoproteins in obese group.
  
  
  
  Significantly raised levels of serum visfatin and interleukin-6 indicate adipose tissue as an imperative source of these adipocytokines involved in inflammation in CAD. Altered lipid profile also seen in obese patients with CAD.
authors.affiliation: Department of Physiology, Lahore Medical and Dental College (LMDC), Lahore.
authors.forename: Shaheena
authors.initials: Sh
authors.lastname: Naz
authors.affiliation: Department of Physiology, Lahore Medical and Dental College (LMDC), Lahore.
authors.forename: Qamar Shakoor
authors.initials: QSh
authors.lastname: Sandhu
authors.affiliation: Department of Physiology, Lahore Medical and Dental College (LMDC), Lahore.
authors.forename: Abida
authors.initials: A
authors.lastname: Akhtar
authors.affiliation: Department of Physiology, Lahore Medical and Dental College (LMDC), Lahore.
authors.forename: Uzma
authors.initials: U
authors.lastname: Zafar
authors.affiliation: Department of Physiology, Lahore Medical and Dental College (LMDC), Lahore.
authors.forename: Attiqa
authors.initials: A
authors.lastname: Khalid
authors.affiliation: Department of Physiology, Postgraduate Medical Institute (PGMI), Lahore.
authors.forename: Muniza
authors.initials: M
authors.lastname: Saeed
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003324:Coronary Artery Disease / Q000097:blood* / Q000209:etiology; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000150:complications
chemical_list: D015415:Biomarkers; D016207:Cytokines; C508600:IL6 protein, human; D015850:Interleukin-6; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human