title: [Coronary Heart Disease at the Patient With Metabolic Syndrome: Strategy of Antianginal Therapy].
abstract: Fist-line drugs in ischemic heart disease are -adrenoblockers. However there are cases when comorbidities limit possibilities of their use. In metabolic syndrome some representatives of this class unfavorably affect insulin sensitivity, carbohydrate and lipid metabolism. Alternative is to use ivabradine - selective inhibitor of If receptors with negative chronotropic activity. Ivabradine is metabolically neutral, has no negative inotropic effect, no influence on atrioventricular conduction and arterial pressure.
authors.affiliation: N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.
authors.forename: N G
authors.initials: NG
authors.lastname: Poteshkina
authors.affiliation: N.I. Pirogov Russian National Research State Medical University, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Troshina
mesh_terms: D001552:Benzazepines / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000627:therapeutic use; D003327:Coronary Disease / Q000150:complications* / Q000628:therapy*; D006339:Heart Rate; D006801:Humans; D000077550:Ivabradine; D024821:Metabolic Syndrome / Q000150:complications* / Q000628:therapy*
chemical_list: D001552:Benzazepines; D002317:Cardiovascular Agents; D000077550:Ivabradine