title: Concurrent with T-zone lymphoma and high-grade gastrointestinal cytotoxic T-cell lymphoma in a dog.
abstract: A 9-year-old, spayed female Golden Retriever dog was referred to us for lymphocytosis and lymphadenopathy, secondary to suspected chronic lymphocytic leukemia (CLL). The dog had a clinical history of anorexia, vomiting and melena lasting two days. The popliteal lymph node contained small-to-intermediate lymphocytes, which led us to suspect low-grade lymphoma. Thickened lesions in the stomach and small intestine were detected by ultrasonography. Histopathology of the popliteal lymph node and small intestine revealed a simultaneous presence of T-zone lymphoma (TZL) and high-grade gastrointestinal (GI) cytotoxic T-cell lymphoma. Large granular lymphocytes (LGLs) were seen on cytological examination. Polymerase chain reaction (PCR) revealed that both lymphomas originated in the T-cells. The dog died 15 days after diagnosis, despite chemotherapy.
authors.affiliation: Sanyo Animal Medical Center, 357-1 Komoto, Akaiwa, Okayama 709-0821, Japan.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Suwa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shimoda
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000276:immunology / Q000662:veterinary*; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000662:veterinary*; D009378:Neoplasms, Multiple Primary / Q000276:immunology / Q000662:veterinary*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*