title: The modification of natural products for medical use.
abstract: Drug innovation is characterized by painstaking molecular-level syntheses and modifications as the basic components of research and development. Similarly, natural products are chemically tailored and modified based upon their structural and biological properties. To some extent, the modification of natural products is quite different fromde novostructure-based drug discovery. This review describes the general strategies and principles for the modification of natural products to drugs, as illustrated by several successful medicines that originated from natural products.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Zongru
authors.initials: Z
authors.lastname: Guo
keywords: Artemisinin; Indirubin; Multi-dimensional optimization; Natural products; Structure–acitivity reactivity; Synthesis