title: Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery.
abstract: In a Perspective, David Bennett makes a case for neural reserve to be considered as a therapeutic endpoint in clinical trials for dementia.
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
authors.forename: David A
authors.initials: DA
authors.lastname: Bennett
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D001921:Brain / Q000502:physiology*; D058245:Cognitive Reserve; D003704:Dementia / Q000188:drug therapy*; D055808:Drug Discovery; D006801:Humans