title: Subgingival Microbiota in White Patients With Desquamative Gingivitis: A Cross-Sectional Study.
abstract: Presence of epithelial desquamation, erythema, and erosions on gingival tissue is usually described in the literature as desquamative gingivitis (DG). A wide range of autoimmune/dermatologic disorders can manifest as DG, although the two more common are oral lichen planus and mucous membrane pemphigoid. The aim of this study is to investigate prevalence of 11 periodontopathogenic microorganisms in patients with DG and to compare it with the microbiologic status of individuals affected by plaque-induced gingivitis (pGI).
  
  
  
  Cross-sectional clinical and microbiologic data were obtained from 66 patients (33 in each group). Subgingival plaque samples were analyzed using semiquantitative polymerase chain reaction analysis.
  
  
  
  Statistically significant difference, but with little clinical significance, was observed in gingival conditions between the two groups, probably due to the worse home control hygiene of patients with DG. Prevalence and levels of Aggregatibacter actinomycetemcomitans, Eikenella corrodens, and Fusobacterium nucleatum/periodonticum were statistically higher in samples from patients with DG than in those with pGI. In multivariate regression models, subgingival colonization of A. actinomycetemcomitans and F. nucleatum/periodonticum was not statistically associated with DG, whereas, high levels of E. corrodens were associated with 13-fold increased odds for DG.
  
  
  
  Microbiologic differences were found in subgingival plaque for patients with DG and pGI. This may suggest possible association between periodontal pathogens and DG.
authors.affiliation: Department of Surgical Sciences, Center for Interdepartmental Research - Dental School, University of Turin, Turin, Italy.
authors.forename: Paolo G
authors.initials: PG
authors.lastname: Arduino
authors.affiliation: Department of Surgical Sciences, Center for Interdepartmental Research - Dental School, University of Turin, Turin, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Romano
authors.affiliation: Department of Surgical Sciences, Center for Interdepartmental Research - Dental School, University of Turin, Turin, Italy.
authors.forename: Danilo
authors.initials: D
authors.lastname: Sasia
authors.affiliation: Department of Surgical Sciences, Center for Interdepartmental Research - Dental School, University of Turin, Turin, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Broccoletti
authors.affiliation: Unit of Epidemiology, Regional Health Service Azienda Sanitaria Locale Torino 3, Grugliasco, Italy.
authors.forename: Fulvio
authors.initials: F
authors.lastname: Ricceri
authors.affiliation: Division of Microbiology and Virology, Azienda Ospedaliero University, Città della Salute e della Scienza - Molinette Hospital, Turin, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Barbui
authors.affiliation: Division of Microbiology and Virology, Azienda Ospedaliero University, Città della Salute e della Scienza - Molinette Hospital, Turin, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Brossa
authors.affiliation: Division of Microbiology and Virology, Azienda Ospedaliero University, Città della Salute e della Scienza - Molinette Hospital, Turin, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Cipriani
authors.affiliation: Department of Surgical Sciences, Center for Interdepartmental Research - Dental School, University of Turin, Turin, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Cricenti
authors.affiliation: Department of Surgical Sciences, Center for Interdepartmental Research - Dental School, University of Turin, Turin, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Cabras
authors.affiliation: Department of Surgical Sciences, Center for Interdepartmental Research - Dental School, University of Turin, Turin, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Aimetti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001419:Bacteria / Q000302:isolation & purification*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005881:Gingiva / Q000382:microbiology*; D005891:Gingivitis / Q000382:microbiology*; D006801:Humans; D008297:Male; D064307:Microbiota; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012044:Regression Analysis; D044465:White People
keywords: Aggregatibacter actinomycetemcomitans; Eikenella corrodens; Fusobacterium nucleatum; cross-sectional studies; gingival diseases; polymerase chain reaction