title: Interferon-I: The Pièce de Résistance of HIV-1 Transmission?
abstract: Despite the extensive viral quasispecies that develops in an individual during the course of HIV-1 infection, transmission is typically established by a single donor viral variant. Recent studies now provide insight into the phenotypic properties influencing this selection process at transmission, including the contribution of resistance to type I interferons.
authors.affiliation: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
authors.forename: Damien C
authors.initials: DC
authors.lastname: Tully
authors.affiliation: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Claiborne
authors.affiliation: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. Electronic address: tallen2@mgh.harvard.edu.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Allen
mesh_terms: D014644:Genetic Variation; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007370:Interferon Type I / Q000276:immunology*; D009092:Mucous Membrane / Q000276:immunology / Q000821:virology; D010802:Phylogeny; D012641:Selection, Genetic
chemical_list: D007370:Interferon Type I
keywords: Bottleneck; HIV; Interferon; Mucosal; Resistance; Transmission