title: [The essentiality and rationality of the Brazilian national listing of essential medicines].
abstract: One strategy to implement the rational use of medicines is the adoption of an 'essential medicines list'. The objective of this study was to analyze the list of medicines contained in the Brazilian National Relation of Essential Medicines (Rename, 2013) in terms of essentiality and rationality. Essentiality was determined by comparing this list to the 18th Essential Medicines List (EML) published by the World Health Organization (WHO). Drugs which were part of the Brazilian National Relation of Essential Medicines but not included in the EML were assessed using the classification described in La revue Prescrire to detect medications without added therapeutic value. It was discovered that the Brazilian National Relation of Essential Medicines contains 190 medications not included in the EML, of which 63 have no added therapeutic value. In addition, discrepancies were identified between the recommendations of the WHO and the drugs included in the Brazilian National Relation of Essential Medicines. It is concluded that drugs that are non-essential and provide no added therapeutic value should not be included in a list of essential medicines funded by the three Brazilian federal entities.
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade de Sorocaba. Rodovia Raposo Tavares Km 92,5. 18023-000 Sorocaba SP Brasil. sueli.gmo@epm.br.
authors.forename: Sueli Miyuki
authors.initials: SM
authors.lastname: Yamauti
authors.affiliation: Instituto de Saúde, Secretaria de Estado da Saúde de São Paulo. São Paulo SP Brasil.
authors.forename: José Ruben de Alcântara
authors.initials: JR
authors.lastname: Bonfim
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade de Sorocaba. Rodovia Raposo Tavares Km 92,5. 18023-000 Sorocaba SP Brasil. sueli.gmo@epm.br.
authors.forename: Silvio
authors.initials: S
authors.lastname: Barberato-Filho
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade de Sorocaba. Rodovia Raposo Tavares Km 92,5. 18023-000 Sorocaba SP Brasil. sueli.gmo@epm.br.
authors.forename: Luciane Cruz
authors.initials: LC
authors.lastname: Lopes
mesh_terms: D001938:Brazil; D018954:Drugs, Essential / Q000145:classification / Q000592:standards* / Q000600:supply & distribution; D006801:Humans; D004364:Pharmaceutical Preparations / Q000145:classification / Q000592:standards* / Q000600:supply & distribution; D014944:World Health Organization
chemical_list: D018954:Drugs, Essential; D004364:Pharmaceutical Preparations