title: The effect of low-level laser therapy on tooth movement during canine distalization.
abstract: The aim of the study is to determine the effects of low level laser therapy on tooth movement during canine distalization by evaluating IL-1β, TGF-β1 levels in gingival crevicular fluid. Maxillary first premolars of the 15 Angle Class II division I patients (12-19 years old) were extracted. Right maxillary canines were distalized by standard protocol as control group whereas the left maxillary canines distalized by laser application. A gallium-aluminum-arsenide diode laser with an output power of 20 mW was applied as five doses from the buccal and the palatal side on the day 0, and the 3rd, 7th, 14th, 21th 30th, 33st, 37th, 60th, 63th, and 67th days. Gingival crevicular fluid samples were obtained with filtration paper at the initial, 7th, 14th, and 21th days, and the IL-1ß and TGF-ß1 cytokine levels were analyzed. Orthodontic models and periodontal indices were taken initially and on the days 30th, 60th, and 90th of canine distalization period. Tooth movement was assessed by scanning models (3Shape). The amount of tooth movement in the laser group was 40% more than the control group. First day IL-1ß levels were statistically higher than initial and 21st day levels (P= 0.003, P = 0.012). The rise in IL-1ß levels caused the negative correlations between 7th day IL-1β and 21st day TGF-β1 levels describes the tissue effects of laser application. Periodontal indices showed no sign of gingival inflammation during canine distalization period. As conclusion, laser does accelerate tooth movement and could shorten the whole treatment duration.
authors.affiliation: Department of Orthodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey. sevinerol@gmail.com.
authors.forename: Sevin Erol
authors.initials: SE
authors.lastname: Üretürk
authors.affiliation: Department of Orthodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: Müyesser
authors.initials: M
authors.lastname: Saraç
authors.affiliation: Department of Orthodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: Sönmez
authors.initials: S
authors.lastname: Fıratlı
authors.affiliation: Department of Biochemistry, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: Şule Batu
authors.initials: ŞB
authors.lastname: Can
authors.affiliation: Department of Biochemistry, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: Yegane
authors.initials: Y
authors.lastname: Güven
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Fıratlı
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D016022:Case-Control Studies; D003481:Cuspid / Q000528:radiation effects*; D003773:Dental Plaque / Q000532:radiotherapy; D005260:Female; D005883:Gingival Crevicular Fluid / Q000378:metabolism; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism; D054023:Lasers, Semiconductor / Q000627:therapeutic use; D028022:Low-Level Light Therapy; D008297:Male; D010512:Periodontal Index; D014085:Tooth Migration / Q000532:radiotherapy*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D053583:Interleukin-1beta; D053773:Transforming Growth Factor beta1
keywords: Canine distalization; IL-1β; Low-level laser therapy; TGF-β; Velocity of orthodontic tooth movement