title: Liposomal Co-Encapsulation of Two Novel Europium Complexes and Doxorubicin: Fluorescence Study.
abstract: The present study was undertaken to design the novel liposomal drug formulation containing doxorubicin and europium coordination complexes. It was shown that co-encapsulation of the drugs facilitates the partitioning and permeation of lanthanides into the lipid bilayer. The obtained results suggest that new drug platform may have potential application in the design of novel antitumor agents.
authors.affiliation: Department of Nuclear and Medical Physics, V.N. Karazin Kharkov National University, 4 Svobody Sq, Kharkov, 61072, Ukraine. valeriya.m.trusova@gmail.com.|, 19-32 Geroyev Truda Str, Kharkov, 61072, Ukraine. valeriya.m.trusova@gmail.com.
authors.forename: Valeriya M
authors.initials: VM
authors.lastname: Trusova
authors.affiliation: Department of Applied Organic Chemistry, Faculty of Chemistry, University of Sofia, 1164, Sofia, Bulgaria.
authors.forename: Todor
authors.initials: T
authors.lastname: Deligeorgiev
authors.affiliation: Department of Nuclear and Medical Physics, V.N. Karazin Kharkov National University, 4 Svobody Sq, Kharkov, 61072, Ukraine.
authors.forename: Galyna
authors.initials: G
authors.lastname: Gorbenko
mesh_terms: D002462:Cell Membrane; D056831:Coordination Complexes / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D005453:Fluorescence; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D010539:Permeability
chemical_list: D056831:Coordination Complexes; D004337:Drug Carriers; D028581:Lanthanoid Series Elements; D008051:Lipid Bilayers; D008081:Liposomes; D005063:Europium; D004317:Doxorubicin
keywords: Doxorubicin; Drug combination; Lanthanides; Liposomal drug formulation