title: A maternal effect mutation leading to deficiencies of organs and homeotic transformations in the adults ofDrosophila.
abstract: The temperature sensitive mutationfs(l)h is characterized at the restrictive temperature of 29°C by both a maternal effect responsible for the early embryonic lethality and pupal zygotic lethality. The two phenotypes are inseparable and map at a short deletion in the X chromosome (7Dl, 7D5-6). At semipermissive temperatures, hemizygous mutant females produce adults with morphological defects, such as organ deficiencies and homeotic transformations of haltere to wing and third leg to second leg. These defects depend on the maternal genotype and are governed by an early temperature sensitive period, which covers the end of oogenesis and the first hours of embryogenesis. Furthermore, this maternal effect mutation interacts with some dominant mutations of the bithorax system. These properties suggest thatfs(l)h is somehow involved in segmental determination.
authors.affiliation: Centre de Génétique Moléculaire, C.N.R.S., F-91, Gif-sur-Yvette, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Forquignon
keywords: Drosophila; Homeotic-mutants; Maternal effect mutant; Pattern formation