title: Serum soluble Talin-1 levels are elevated in patients with multiple sclerosis, reflecting its disease activity.
abstract: Previously, we identified anti-Talin-1 antibodies in the serum of MS. In this case, we measured the serum soluble Talin-1 (sTalin-1) levels by enzyme-linked immunosorbent assay. The serum sTalin-1 levels were significantly higher in 40 patients with MS than in 43 normal controls and in the acute phase of disease than in the remission phase. Interestingly, serum sTalin-1 levels were associated with a sustained increase in disability after MS attack but not with serum anti-Talin-1 antibody levels. sTalin-1 may be a biomarker for the acute phase of MS and may be used for the short-term prognosis of MS.
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Muto
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address: morim@faculty.chiba-u.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mori
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Uzawa
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Masuda
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Ohtani
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sugimoto
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000134:cerebrospinal fluid / Q000503:physiopathology; D012720:Severity of Illness Index; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D016608:Talin / Q000097:blood* / Q000134:cerebrospinal fluid / Q000276:immunology; D055815:Young Adult
chemical_list: D000906:Antibodies; C518832:TLN1 protein, human; D016608:Talin
keywords: Multiple sclerosis; SEREX; Soluble Talin-1; Talin-1 protein; anti-Talin-1 antibody