title: Proteomic Analysis of Liver Proteins in a Rat Model of Chronic Restraint Stress-Induced Depression.
abstract: Depression is a global mental disorder disease and greatly threatened human health and stress is considered to be one of the important factors that lead to depression. In this study, we used newly developed iTRAQ labeling and high performance liquid chromatography (HPLC) and mass spectrum united analysis technology obtained the 2176 accurate proteins. Successively, we used the GO analysis and IPA software to analyze the 98 differentially expressed proteins of liver in depression rats due to chronic restraint stress, showing a map of proteomics analysis of liver proteins from the aspects of related functions, disease and function analysis, canonical pathway analysis, and associated network. This study provide important information for comprehensively understanding the mechanisms of dysfunction or injury in the liver in depression.
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan Dong Lu 11, Chao Yang District, Beijing 100029, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Li
authors.affiliation: Institute of Basic Medical Sciences, Academy of Medical Science, Peking Union Medical College, Dong Dan San Tiao, Dong Cheng District, Beijing 100005, China.
authors.forename: Zhengguang
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan Dong Lu 11, Chao Yang District, Beijing 100029, China.
authors.forename: Ronghua
authors.identifier: 0000-0001-5254-5000
authors.initials: R
authors.lastname: Zhao
authors.affiliation: Institute of Basic Medical Sciences, Academy of Medical Science, Peking Union Medical College, Dong Dan San Tiao, Dong Cheng District, Beijing 100005, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan Dong Lu 11, Chao Yang District, Beijing 100029, China.
authors.forename: Ming
authors.identifier: 0000-0003-3189-1216
authors.initials: M
authors.lastname: Xie
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D030562:Databases, Protein; D003863:Depression / Q000150:complications / Q000378:metabolism*; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D007103:Immobilization; D008099:Liver / Q000378:metabolism*; D008297:Male; D040901:Proteomics / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D012269:Ribosomal Proteins / Q000737:chemistry; D015398:Signal Transduction; D012984:Software; D013315:Stress, Psychological; D053719:Tandem Mass Spectrometry
chemical_list: D012269:Ribosomal Proteins; C063565:Rpl35 protein, rat