title: The Effect of a Home Delivery Meal Service of Energy- and Protein-Rich Meals on Quality of Life in Malnourished Outpatients Suffering from Lung Cancer: A Randomized Controlled Trial.
abstract: Undernutrition is prevalent in cancer patients and associated with increased incidence of complications and mortality. We investigated the effects of a home delivery meal service, providing a selection of energy-dense, protein-rich meals, on quality of life (QoL) in malnourished lung cancer patients. Forty lung cancer patients with nutritional risk score ≥3 (NRS-2002) were randomized to control or intervention. The intervention group was offered energy- and protein-rich main meals and snacks, delivered 3 times per week. The control group continued their habitual diet. Primary endpoint, QoL, and secondary endpoints were assessed at baseline, and after 6 and 12 wk. Data on unplanned readmissions, length of hospital stay, and mortality were collected 3 and 6 mo post-intervention. Intervention group improved standard Chair Stand Test (30-s CST) after 6 and 12 wk (P < 0.01) compared to control. Intervention exerted a significant positive effect on performance score after 12 wk (P  =  0.047). Increased energy and protein intakes were strongly associated with improved QoL, functional score, hand grip strength, symptom and performance scores. Food delivery service with energy- and protein-rich main meals and snacks can improve lower body strength and performance status in malnourished lung cancer patients.
authors.affiliation: a Clinical Nutrition Research Unit , Copenhagen University Hospital Herlev-Gentofte , Gentofte , Denmark.
authors.forename: Eva
authors.initials: E
authors.lastname: Leedo
authors.affiliation: a Clinical Nutrition Research Unit , Copenhagen University Hospital Herlev-Gentofte , Gentofte , Denmark.
authors.forename: Josephine
authors.initials: J
authors.lastname: Gade
authors.affiliation: a Clinical Nutrition Research Unit , Copenhagen University Hospital Herlev-Gentofte , Gentofte , Denmark.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Granov
authors.affiliation: b Department of Oncology , Herlev University Hospital , Herlev , Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Mellemgaard
authors.affiliation: c Department of Hematology , Copenhagen University Hospital Herlev-Gentofte , Hellerup , Denmark.
authors.forename: Tobias Wirenfeldt
authors.initials: TW
authors.lastname: Klausen
authors.affiliation: a Clinical Nutrition Research Unit , Copenhagen University Hospital Herlev-Gentofte , Gentofte , Denmark.
authors.forename: Katrine
authors.initials: K
authors.lastname: Rask
authors.affiliation: a Clinical Nutrition Research Unit , Copenhagen University Hospital Herlev-Gentofte , Gentofte , Denmark.|d Department of Nutrition , Exercise and Sports, University of Copenhagen , Copenhagen , Denmark.
authors.forename: Arne
authors.initials: A
authors.lastname: Astrup
mesh_terms: D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage*; D023381:Endpoint Determination; D005260:Female; D005522:Food Services; D018737:Hand Strength; D006801:Humans; D007902:Length of Stay; D008175:Lung Neoplasms / Q000150:complications / Q000178:diet therapy* / Q000188:drug therapy; D008297:Male; D044342:Malnutrition / Q000178:diet therapy / Q000453:epidemiology* / Q000209:etiology; D062407:Meals; D008875:Middle Aged; D015596:Nutrition Assessment; D010045:Outpatients; D015995:Prevalence; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D004044:Dietary Proteins