title: Glutamoptosis: A new cell death mechanism inhibited by autophagy during nutritional imbalance.
abstract: Glutaminolysis plays a critical role in nutrient sufficiency and cell signaling activation in mammalian cells. Unexpectedly, our recent investigations revealed that the unbalanced activation of glutaminolysis during nutritional restriction causes a particular form of apoptotic cell death, that we termed "glutamoptosis." We found that the inhibition of autophagy is a key step to allow glutamoptosis-mediated cell death. Thus, autophagy controls glutamoptosis during nutritional imbalance.
authors.affiliation: a Institut Européen de Chimie et Biologie, ACTION Unit U1218, INSERM and University of Bordeaux , Pessac , France.
authors.forename: Victor H
authors.initials: VH
authors.lastname: Villar
authors.affiliation: a Institut Européen de Chimie et Biologie, ACTION Unit U1218, INSERM and University of Bordeaux , Pessac , France.
authors.forename: Raúl V
authors.initials: RV
authors.lastname: Durán
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001343:Autophagy / Q000187:drug effects; D005973:Glutamine / Q000494:pharmacology*; D006801:Humans; D007656:Ketoglutaric Acids / Q000378:metabolism; D000076222:Mechanistic Target of Rapamycin Complex 1 / Q000378:metabolism; D008954:Models, Biological; D009752:Nutritional Status
chemical_list: D007656:Ketoglutaric Acids; D005973:Glutamine; D000076222:Mechanistic Target of Rapamycin Complex 1
keywords: MTORC1; SQSTM1/p62; apoptosis; autophagy; glutaminolysis; α-ketoglutarate