title: Developmental profiles of gangliosides in mouse and rat cerebral cortex.
abstract: Developmental profiles of 11 gangliosides, concentration of lipid- and glycoprotein-bound sialic acid, and activity of AChE of the rat and mouse cerebral cortex were followed from the 7thday of gestation to the 21stpostnatal day.There are three main changes in ganglioside concentration, which are similar in both species. The first occurs from gestation day 10 until birth: parallel to decreased proliferation, cell migration, and neuroblast differentiation, GM3and GD3in mouse cortex and GD3in the rat's decreases in favor of GQ1b, GT1b, and GD1a.The second occurs from birth until the first postnatal week: Parallel to increased growth and arborization of dendrites and axons as well as synaptogenesis in rats and mice, there is a two-fold rise of GD1a, whereas GQ1band GT1bremain on a nearly constant level. Concomitantly, GM3and GD3decreases. The third period of ganglioside changes starts in the second postnatal week, parallel to onset of myelination, and is characterized by an increase of GM1in parallel with a decrease of the polysialogangliosides GT1band GQ1b.
authors.affiliation: Institut für Zoologie der Universität Hohenheim, Garbenstraße 30, D-7000, Stuttgart 70, Federal Republic of Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Hilbig
authors.affiliation: Institut für Zoologie der Universität Hohenheim, Garbenstraße 30, D-7000, Stuttgart 70, Federal Republic of Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Rösner
authors.affiliation: Institut für Zoologie der Universität Hohenheim, Garbenstraße 30, D-7000, Stuttgart 70, Federal Republic of Germany.
authors.forename: Gertraude
authors.initials: G
authors.lastname: Merz
authors.affiliation: Institut für Zoologie der Universität Hohenheim, Garbenstraße 30, D-7000, Stuttgart 70, Federal Republic of Germany.
authors.forename: Kordula
authors.initials: K
authors.lastname: Segler-Stahl
authors.affiliation: Institut für Zoologie der Universität Hohenheim, Garbenstraße 30, D-7000, Stuttgart 70, Federal Republic of Germany.
authors.forename: Hinrich
authors.initials: H
authors.lastname: Rahmann
keywords: AChE; Brain cortex; Development; Gangliosides; Glycoproteins; Mammals