title: The study of association of Vitamin B12deficiency in type 2 diabetes mellitus with and without diabetic nephropathy in North Indian Population.
abstract: OBJECTIVE
  Diabetic Mellitus is the chronic metabolic disorder associated with various complications of heart, eyes, nerves, kidney etc. Diabetic Nephropathy is one of the leading causes of death in diabetic patient. We hypothesized that decrease Vitamin B12levels is associated with Diabetic Nephropathy. Aim of our study is to study the serum Vitamin B12levels in type 2 diabetes mellitus patients with and without nephropathy.
  
  
  METHODS
  Our study population consist of 100 subjects out of which 50 cases of Diabetes Mellitus without Diabetic Nephropathy and 50 cases of Diabetes Mellitus with Diabetic Nephropathy. We measured various routine lab parameters, apart from it, we measured spot urinary albumin to creatinine ratio to assess diabetic nephropathy and in special investigation we measured serum Vitamin B12by chemiluminesence based immunoassay.
  
  
  RESULTS
  Serum Vitamin B12level in the group with nephropathy (181.6±17.6pg/dl) was significantly lower than in the group without nephropathy (286±30.1pg/dl) (p=0.03).
  
  
  CONCLUSIONS
  Our study points towards the decrease levels of serum Vitamin B12levels associated with the complication of diabetic mellitus such as diabetic nephropathy. So treatment of Vitamin B12deficiency by supplementing could prevent the development and progression of diabetic nephropathy and improves the overall management of diabetic patient.
authors.affiliation: Department of Accident and Emergency Medicine, Lady Hardinge Medical College (LHMC), New Delhi, India. Electronic address: sunny86lhmc@gmail.com.
authors.forename: Sonny
authors.initials: S
authors.lastname: Bherwani
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India. Electronic address: drashoklhmc@gmail.com.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Ahirwar
authors.affiliation: Department of Pathology, Lady Hardinge Medical College (LHMC), New Delhi, India. Electronic address: nair.saumya06@gmail.com.
authors.forename: A S
authors.initials: AS
authors.lastname: Saumya
authors.affiliation: Department of Chest and TB, PGIMS, Rhotak, Haryana, India. Electronic address: dr.nair.sandhya@gmail.com.
authors.forename: A S
authors.initials: AS
authors.lastname: Sandhya
authors.affiliation: Department of Pulmonary and Critical Care, PGIMS, Rhotak, Haryana, India. Electronic address: dr.brijeshprajapat@gmail.com.
authors.forename: Brijesh
authors.initials: B
authors.lastname: Prajapat
authors.affiliation: Max Super Specialty Hospital, Saket, New Delhi, India. Electronic address: situssmc@gmail.com.
authors.forename: Sitendu
authors.initials: S
authors.lastname: Patel
authors.affiliation: Department of Biochemistry, LN Medical College and JK Hospital, Bhopal, MP, India. Electronic address: srushteeghate@gmail.com.
authors.forename: Srushtee Bipin
authors.initials: SB
authors.lastname: Jibhkate
authors.affiliation: Department of Biochemistry, Lady Hardinge Medical College (LHMC), New Delhi, India. Electronic address: drritusingh19@gmail.com.
authors.forename: Ritu
authors.initials: R
authors.lastname: Singh
authors.affiliation: Department of Medicine, Lady Hardinge Medical College (LHMC), New Delhi, India. Electronic address: rajghotekar@rediffmail.com.
authors.forename: L H
authors.initials: LH
authors.lastname: Ghotekar
mesh_terms: D000419:Albuminuria; D003404:Creatinine / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007194:India / Q000453:epidemiology; D014805:Vitamin B 12 / Q000097:blood; D014806:Vitamin B 12 Deficiency / Q000150:complications / Q000453:epidemiology*
chemical_list: D003404:Creatinine; D014805:Vitamin B 12
keywords: Diabetes mellitus; Diabetic nephropathy; Serum Vitamin B(12) levels