title: Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.
abstract: A series of selenides, diselenides and organoselenoheterocycles were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors against the human (h) isoforms hCA I, II, IV, VII and IX, involved in a variety of diseases among which glaucoma, retinitis pigmentosa, epilepsy, arthritis and tumors etc. These investigated compounds showed inhibitory action against these isoforms and some of them were selective for inhibiting the cytosolic over the membrane-bound isoforms, thus making them interesting leads for the development of isoform-selective inhibitors.
authors.affiliation: Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Angeli
authors.affiliation: Università degli Studi di Firenze, Department of Chemistry "Ugo Schiff", Via della Lastruccia 3-13, I-50019 Sesto Fiorentino, Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Tanini
authors.affiliation: Università degli Studi di Firenze, Department of Chemistry "Ugo Schiff", Via della Lastruccia 3-13, I-50019 Sesto Fiorentino, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Viglianisi
authors.affiliation: University of Naples "Federico II", Department of Chemical Sciences, Via Cintia 4, I-80126 Naples, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Panzella
authors.affiliation: Università degli Studi di Firenze, Department of Chemistry "Ugo Schiff", Via della Lastruccia 3-13, I-50019 Sesto Fiorentino, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Capperucci
authors.affiliation: Università degli Studi di Firenze, Department of Chemistry "Ugo Schiff", Via della Lastruccia 3-13, I-50019 Sesto Fiorentino, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Menichetti
authors.affiliation: Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address: claudiu.supuran@unifi.it.
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D018036:Selenium Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D007527:Isoenzymes; D018036:Selenium Compounds; D002256:Carbonic Anhydrases
keywords: Carbonic anhydrase; Diselenides; Inhibitors; Metalloenzymes; Selenides; Selenium; Selenoheterocycles