title: [Recurrent urinary tract infections: prevention of recurrence with intravesical instillations of chondroitin sulfate and hyaluronic acid.]
abstract: OBJECTIVE
  The aim of our study is to demonstrate that intravesical administration of the association chondroitin sulfate (CS) and hyaluronic acid (HA), according to our treatment schedule, is a benefit for women with recurrent urinary tract infections (RUTI), not only from a clinical point of view, but also reducing recurrences.
  
  
  METHODS
  This is a study of 28 women diagnosed with RUTI, with a positive culture, and compatible symptoms;frethey underwent treatment according to the protocol of intravesical instillations of the combination CS 2%-1 gr + HA 1.6%-800 mg. To evaluate the effectiveness of the treatment, symptoms improvement, reduction of the number of episodes of urinary tract infection and quality of life were considered.
  
  
  RESULTS
  In our series, we can observe an improvement of the quality of life assessed by PG-I, 66% after 12 months. It was seen that 55.6% of the patient's urine cultures became negative, while 44.4% had episodes of urinary infection, but with lower baseline symptoms intensity.
  
  
  CONCLUSIONS
  Patients included in the protocol of instillation improved significantly their quality of life; in addition, to a considerable extent new urinary infections were not presented, being milder when they presented.
authors.affiliation: Servicio de Urología. Hospital Clínico Universitario Virgen de la Arrixaca. El Palmar. Murcia. España.
authors.forename: Jesús Ignacio
authors.initials: JI
authors.lastname: Tornero Ruiz
authors.affiliation: Servicio de Urología. Hospital Clínico Universitario Virgen de la Arrixaca. El Palmar. Murcia. España.
authors.forename: Gloria
authors.initials: G
authors.lastname: Martínez Gómez
authors.affiliation: Servicio de Urología. Hospital Clínico Universitario Virgen de la Arrixaca. El Palmar. Murcia. España.
authors.forename: José Félix
authors.initials: JF
authors.lastname: Escudero Bregante
authors.affiliation: Servicio de Urología. Hospital Clínico Universitario Virgen de la Arrixaca. El Palmar. Murcia. España.
authors.forename: Guillermo Antonio
authors.initials: GA
authors.lastname: Gómez Gómez
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002809:Chondroitin Sulfates / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D008875:Middle Aged; D011788:Quality of Life; D012008:Recurrence; D014552:Urinary Tract Infections / Q000517:prevention & control*
chemical_list: D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates