title: Memory B cells in Guillain-Barré syndrome.
abstract: IgG autoantibodies against gangliosides show the highest titers at the disease onset of axonal Guillain-Barré syndrome (GBS), in which there are no IgM anti-ganglioside antibodies. We hypothesized that memory B cells take part in the development of producing IgG autoantibodies. In this study, we analyzed the memory B cells in patients with GBS using flow cytometry. There was significantly higher percentage of memory B cells in patients with GBS than the healthy controls. The Spearman correlation analysis demonstrated that increased percentage of memory B cells was positively correlated with the clinical severity of the patients with GBS. Our study provides the evidences that memory B cells may be involved in mechanism of GBS.
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
authors.forename: Chunye
authors.initials: C
authors.lastname: Xing
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
authors.forename: Yanlei
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
authors.forename: Qiguang
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
authors.forename: Ziyou
authors.initials: Z
authors.lastname: Qi
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
authors.forename: Zhanyun
authors.initials: Z
authors.lastname: Lv
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
authors.forename: Xungang
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China. Electronic address: wangyuzhong1234@163.com.
authors.forename: Yuzhong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Mishima Hospital, Niigata, Japan. Electronic address: gbs.yuki.cidp@gmail.com.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015703:Antigens, CD / Q000378:metabolism; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015703:Antigens, CD
keywords: Guillain-Barré syndrome; memory B cell