title: Estimation of Serum Beta 2-Microglobulin Levels in Individuals Exposed to Carcinogens: Clinical Study in Indian Population.
abstract: OBJECTIVE
  The aim of the study is to evaluate the prognostic value of β2-m as a biochemical parameter for the diagnosis and prognosis of oral squamous cell carcinoma (SCC).
  
  
  METHODS
  The study included 60 patients(15 oral SCC, 15 leukoplakia, 15 individuals exposed to various carcinogens and without oral cancerous or precancerous lesions, 15 healthy individuals). The levels of β2-m were estimated using chemi-luminescent immunometric assay on Immulite fully automated machine. Statistical analysis of the data was done using Tuckey's test, ANOVA and independent samplettest.
  
  
  RESULTS
  Results showed that β2-m was increased in individuals exposed to carcinogens without precancerous and cancerous lesion.
  
  
  CONCLUSIONS
  Serum β2-m can be used as a better indicator and can give an early indication of malignant change and therefore malignancy can be detected at an early and treatable stage.
authors.affiliation: Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra India.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Saddiwal
authors.affiliation: Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra India.
authors.forename: Manjula
authors.initials: M
authors.lastname: Hebbale
authors.affiliation: Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra 411043 India.
authors.forename: Vikrant Dilip
authors.initials: VD
authors.lastname: Sane
authors.affiliation: Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra India.
authors.forename: Darshan
authors.initials: D
authors.lastname: Hiremutt
authors.affiliation: Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra 411043 India.
authors.forename: Rohan
authors.initials: R
authors.lastname: Gupta
authors.affiliation: Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra 411043 India.
authors.forename: Yash
authors.initials: Y
authors.lastname: Merchant
keywords: Chemiluminescent immunometric assay; Oral cancer; Tumor markers; β2-Microglobulin