title: Nitrosocarbonyl-Henry and Denitration Cascade: Synthesis of α-Ketoamides and α-Keto Oximes.
abstract: An unprecedented Henry reaction of in situ generated nitrosocarbonyl intermediates and concomitant denitration cascade has been developed. The reaction is catalyzed by organic base at room temperature offering α-ketoamides, a demanding scaffold for drug discovery, in high yields. An alteration of substitution pattern also produced α-keto oximes, a high-value synthon. The protocol features operational simplicity and broad substrate scope.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai 600 036, Tamil Nadu, India.
authors.forename: Mallu Kesava
authors.initials: MK
authors.lastname: Reddy
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai 600 036, Tamil Nadu, India.
authors.forename: Sumitava
authors.initials: S
authors.lastname: Mallik
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai 600 036, Tamil Nadu, India.
authors.forename: Isai
authors.initials: I
authors.lastname: Ramakrishna
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai 600 036, Tamil Nadu, India.
authors.forename: Mahiuddin
authors.identifier: 0000-0001-9415-7137
authors.initials: M
authors.lastname: Baidya