title: The role of Siglec-1 in HIV-1/macrophage interaction.
abstract: Although CD4 T-cells are a major target for HIV, recent work has demonstrated the ability of macrophages despite expressing relatively low levels of CD4, to be a target of the virus. Our recent study has found that the presence of growth factors not only play a role in the phenotype of these monocyte-derived-macrophages, but also are an important aspect of the permissiveness of these cells to infection. The work utilized cellular and biophysical methods to examine Siglec-1 on macrophages as a primary receptor in HIV-1 infection. These findings support the notion that Siglec-1 and macrophages and their interactions with the HIV-1 envelope should be considered in HIV-1 vaccine development.
authors.affiliation: Henry M. Jackson Foundation for the Advancement of Military Medicine, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, 20910, USA; Laboratory of Adjuvant and Antigen Research, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, 20910, USA.
authors.forename: Ousman
authors.initials: O
authors.lastname: Jobe
authors.affiliation: Henry M. Jackson Foundation for the Advancement of Military Medicine, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, 20910, USA; Laboratory of Adjuvant and Antigen Research, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, 20910, USA.
authors.forename: Jiae
authors.initials: J
authors.lastname: Kim
authors.affiliation: Laboratory of Adjuvant and Antigen Research, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, 20910, USA.
authors.forename: Mangala
authors.initials: M
authors.lastname: Rao
keywords: GM-CSF; HIV-1; M-CSF; Siglec-1; macrophages