title: Genetics of coronary artery disease: discovery, biology and clinical translation.
abstract: Coronary artery disease is the leading global cause of mortality. Long recognized to be heritable, recent advances have started to unravel the genetic architecture of the disease. Common variant association studies have linked approximately 60 genetic loci to coronary risk. Large-scale gene sequencing efforts and functional studies have facilitated a better understanding of causal risk factors, elucidated underlying biology and informed the development of new therapeutics. Moving forwards, genetic testing could enable precision medicine approaches by identifying subgroups of patients at increased risk of coronary artery disease or those with a specific driving pathophysiology in whom a therapeutic or preventive approach would be most useful.
authors.affiliation: Division of Cardiology, Department of Medicine and Center for Genomic Medicine, Massachusetts General Hospital; Cardiovascular Disease Initiative, Broad Institute of Harvard and Massachusetts Institute of Technology, 185 Cambridge Street, CPZN 5.252, Boston, Massachusetts 02114, USA.
authors.forename: Amit V
authors.initials: AV
authors.lastname: Khera
authors.affiliation: Division of Cardiology, Department of Medicine and Center for Genomic Medicine, Massachusetts General Hospital; Cardiovascular Disease Initiative, Broad Institute of Harvard and Massachusetts Institute of Technology, 185 Cambridge Street, CPZN 5.252, Boston, Massachusetts 02114, USA.
authors.forename: Sekar
authors.initials: S
authors.lastname: Kathiresan
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D057285:Precision Medicine; D057170:Translational Research, Biomedical