title: Local ocular surface parameters in patients with systemic celiac disease.
abstract: PurposeThis was a collaborative study from the Ophthalmology and Gastroenterology departments of a tertiary care hospital, designed to investigate the local ocular surface parameters in patients with celiac disease (CD).MethodsFifty-six eyes of 28 patients with CD and 58 eyes of 29 healthy adult subjects serving as controls were evaluated. The Schirmer test, tear-film break-up time, and conjunctival impression cytology were performed in addition to a complete ophthalmological examination. Impression cytology specimens of each group were graded and scored in the range 0-3.ResultsThe 28 patients with CD consisted of 24 females (86%) and 4 males (14%). The mean age was 34.4±11.3 years (22-55 years). Tear-film break-up time and Schirmer test results were significantly lower in the study group than in the controls (P<0.05). Also, there was a significant difference between the groups for impression cytology grading scores (P=0.001).ConclusionsThe CD group showed a marked preponderance of females with an F/M ratio of six females per male, as reported in the literature. Tear-film functions and conjunctival surface epithelial morphology were significantly altered in patients with CD.
authors.affiliation: SB Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
authors.forename: M M
authors.initials: MM
authors.lastname: Uzel
authors.affiliation: SB Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Citirik
authors.affiliation: Department of Gastroenterology, SB Ankara Teaching and Research Hospital, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kekilli
authors.affiliation: SB Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
authors.forename: P
authors.initials: P
authors.lastname: Cicek
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis; D003228:Conjunctiva / Q000473:pathology*; D003315:Cornea / Q000473:pathology*; D003941:Diagnostic Techniques, Ophthalmological; D015352:Dry Eye Syndromes / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012590:Sclera / Q000473:pathology*; D012720:Severity of Illness Index; D013666:Tears / Q000378:metabolism; D055815:Young Adult