title: Head regeneration and polarity reversal inHydra attenuata can occur in the absence of DNA synthesis.
abstract: Regeneration in hydra is considered to be morphallactic because it can occur in the absence of cell division. Whether DNA synthesis is required for regeneration or other repatterning events is not known. The question was investigated by blocking DNA synthesis with hydroxyurea and examining several developmental processes. Head regeneration, reversal of regeneration polarity and battery cell differentiation all took place in the absence of DNA synthesis. Hence, morphallactic regulation in hydra is independent of both DNA synthesis and mitosis.
authors.affiliation: Developmental Biology Center and Department of Developmental and Cell Biology, University of California, 92717, Irvine, California, USA.
authors.forename: Susan G
authors.initials: SG
authors.lastname: Cummings
authors.affiliation: Developmental Biology Center and Department of Developmental and Cell Biology, University of California, 92717, Irvine, California, USA.
authors.forename: Hans R
authors.initials: HR
authors.lastname: Bode
keywords: DNA synthesis; Epithelial cells; Hydra; Morphallactic regeneration; Polarity reversal