title: [Generalized circumscribed scleroderma with blisters].
abstract: The patient suffered from a 20-year course of generalized circumscribed scleroderma and presented with blisters in circumscribed areas of the affected skin. The development of subepidermal blisters has been described in all clinical forms of circumscribed scleroderma. Aetiology and pathogenesis of blister formation have not yet been clarified. An obstruction of the lymphatic vessels due to the present sclerosis is favoured. Treatment of bullous circumscribed scleroderma is considered to be difficult. Oral steroids, methotrexate, hydroxychloroquine and PUVA methods have been used with varying success.
authors.affiliation: Klinik für Dermatologie, Allergologie und Phlebologie, Klinikum Bremerhaven Reinkenheide, Postbrookstr. 103, 27574, Bremerhaven, Deutschland. gunnar.wagner@klinikum-bremerhaven.de.
authors.forename: G
authors.initials: G
authors.lastname: Wagner
authors.affiliation: Klinik für Dermatologie, Allergologie und Phlebologie, Klinikum Bremerhaven Reinkenheide, Postbrookstr. 103, 27574, Bremerhaven, Deutschland.
authors.forename: V
authors.initials: V
authors.lastname: Meyer
authors.affiliation: Klinik für Dermatologie, Allergologie und Phlebologie, Klinikum Bremerhaven Reinkenheide, Postbrookstr. 103, 27574, Bremerhaven, Deutschland.
authors.forename: M M
authors.initials: MM
authors.lastname: Sachse
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D001706:Biopsy; D001768:Blister / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D010406:Penicillins / Q000627:therapeutic use; D011239:Prednisolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D012008:Recurrence; D012594:Scleroderma, Localized / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012867:Skin / Q000473:pathology; D014467:Ultraviolet Therapy
chemical_list: D010406:Penicillins; D011239:Prednisolone; C035287:prednicarbate; D008727:Methotrexate
keywords: Bullous morphea; Herpes zoster; Hydroxychloroquine; Obstructed lymphatic vessels; Subepidermal blistering