title: Promoter polymorphism (T-1486C) of TLR-9 gene is associated with knee osteoarthritis in a Turkish population.
abstract: In this study, we aimed to determine whether TLR-9 T-1486C SNP was associated with susceptibility to OA in the Turkish population. The study group comprised 272 patients with Grade 2-3-4 knee OA according to the Kellgren-Lawrence scoring system and the control group was formed of 296 individuals with Grade 0-1. The TLR-9 genotype were assessed by real-time polymerase chain reaction. An analysis of TLR-9 promoter -1486T/C polymorphism revealed that the -1486CC genotype appeared to have a higher risk for OA and -1486TT and -1486CT genotypes have a protective effect against the development of OA (crude OR = 0.473, 95% CI = 0.297-0.754, p = 0.002, adjusted OR = 0.531, 95% CI = 0.326-0.864, p = 0.011). This study indicate that there is a correlation of TLR-9 T-1486C gene polymorphism with advanced knee OA in a Turkish population. Changed in TLR expression due to different allelles may cause osteoarthrith development outcome cartilage degeneration. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2484-2489, 2017.
authors.affiliation: Department of Physical Treatment and Rehabilitation, Bozok University, Yozgat, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Balbaloglu
authors.affiliation: Department of Medical Biology, Bozok University, Yozgat, Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Sabah Ozcan
authors.affiliation: Department of Orthopaedics and Traumatology, Bozok University, Yozgat, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Korkmaz
authors.affiliation: Department of Microbiology, Bozok University, Yozgat, Turkey.
authors.forename: Neziha
authors.initials: N
authors.lastname: Yılmaz
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D051217:Toll-Like Receptor 9 / Q000235:genetics*; D014421:Turkey
chemical_list: C495371:TLR9 protein, human; D051217:Toll-Like Receptor 9
keywords: osteoarthritis; single nucleotide polymorphism; toll-like receptor