title: Pediococcus spp.: An important genus of lactic acid bacteria and pediocin producers.
abstract: Probiotics have gained increasing attention due to several health benefits related to the human digestive and immune systems. Pediococcus spp. are lactic acid bacteria (LAB) that are widely described as probiotics and characterized as coccus-shaped bacteria (arranged in tetrads), Gram-positive, non-motile, non-spore forming, catalase-negative, and facultative anaerobes. There are many Pediococcus strains that produce pediocin, an effective antilisterial bacteriocin. Pediocins are small, cationic molecules consisting of a conserved hydrophilic N-terminal portion containing the YGNGV motif and an amphiphilic or hydrophobic C-terminal variable portion. A number of studies have been developed with Pediococcus isolated from multiple biological niches to conduct fermentation processes for pediocin or Pediococcus cell production. This review gathers the most significant information about the cultivation, mode of action, and variability of bacteriocins produced by Pediococcus spp., emphasizing their applications in the areas of food and clinical practice. This updated panorama assists in delimiting the challenges that still need to be overcome for pediocin use to be approved for human consumption and the food industry.
authors.affiliation: Biochemical and Pharmaceutical Technology Department, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Lineu Prestes 580, São Paulo 05508-900, Brazil.
authors.forename: Maria Carolina W
authors.initials: MC
authors.lastname: Porto
authors.affiliation: Biochemical and Pharmaceutical Technology Department, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Lineu Prestes 580, São Paulo 05508-900, Brazil.
authors.forename: Taís Mayumi
authors.initials: TM
authors.lastname: Kuniyoshi
authors.affiliation: Biochemical and Pharmaceutical Technology Department, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Lineu Prestes 580, São Paulo 05508-900, Brazil.
authors.forename: P O S
authors.initials: PO
authors.lastname: Azevedo
authors.affiliation: Biochemical and Pharmaceutical Technology Department, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Lineu Prestes 580, São Paulo 05508-900, Brazil.
authors.forename: Michele
authors.initials: M
authors.lastname: Vitolo
authors.affiliation: Biochemical and Pharmaceutical Technology Department, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Lineu Prestes 580, São Paulo 05508-900, Brazil. Electronic address: rpsolive@usp.br.
authors.forename: R P S
authors.initials: RP
authors.lastname: Oliveira
mesh_terms: D005285:Fermentation; D005516:Food Microbiology; D000070017:Pediocins; D010376:Pediococcus; D019936:Probiotics
chemical_list: D000070017:Pediocins
keywords: Anti-Listeria; Bacteriocin; Lactic acid bacteria; Pediocins; Pediococcus spp.