title: Nerve Dependence: From Regeneration to Cancer.
abstract: Nerve dependence has long been described in animal regeneration, where the outgrowth of axons is necessary to the reconstitution of lost body parts and tissue remodeling in various species. Recent discoveries have demonstrated that denervation can suppress tumor growth and metastasis, pointing to nerve dependence in cancer. Regeneration and cancer share similarities in regard to the stimulatory role of nerves, and there are indications that the stem cell compartment is a preferred target of innervation. Thus, the neurobiology of cancer is an emerging discipline that opens new perspectives in oncology.
authors.affiliation: UFR de Biologie, Université de Lille, 59655 Villeneuve d'Ascq, France.
authors.forename: Benoni
authors.initials: B
authors.lastname: Boilly
authors.affiliation: School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia.
authors.forename: Sam
authors.initials: S
authors.lastname: Faulkner
authors.affiliation: School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia.
authors.forename: Phillip
authors.initials: P
authors.lastname: Jobling
authors.affiliation: School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia. Electronic address: hubert.hondermarck@newcastle.edu.au.
authors.forename: Hubert
authors.initials: H
authors.lastname: Hondermarck
mesh_terms: D001369:Axons / Q000502:physiology; D049109:Cell Proliferation; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D020932:Nerve Growth Factor / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D058953:Neural Stem Cells / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology
chemical_list: D009479:Neuropeptides; D018377:Neurotransmitter Agents; D020932:Nerve Growth Factor
keywords: Schwann cells; cancer; nerve dependence; nerve infiltration; neurotrophic growth factors; regeneration; tumor microenvironment