title: Erythrocytes from hereditary xerocytosis patients heterozygous for KCNN4 V282M exhibit increased spontaneous Gardos channel-like activity inhibited by senicapoc.
authors.affiliation: Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.|Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Alicia
authors.initials: A
authors.lastname: Rivera
authors.affiliation: Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.|Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Vandorpe
authors.affiliation: Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.|Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Boris E
authors.initials: BE
authors.lastname: Shmukler
authors.affiliation: Quest Diagnostics, Marlborough, Massachusetts, USA.
authors.forename: Denis R
authors.initials: DR
authors.lastname: Gallagher
authors.affiliation: Quest Diagnostics, Marlborough, Massachusetts, USA.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Fikry
authors.affiliation: Childrens' Hospital of Oakland Research Institute, Oakland, California, USA.
authors.forename: Frans A
authors.initials: FA
authors.lastname: Kuypers
authors.affiliation: Division of Laboratory Medicine, Boston Childrens' Hospital, Harvard Medical School, Boston, Massachusetts, USA.|Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Carlo
authors.identifier: 0000-0001-8192-8713
authors.initials: C
authors.lastname: Brugnara
authors.affiliation: Quest Diagnostics, Marlborough, Massachusetts, USA.|Departments of Medicine and Pathology, UMass Memorial Medical Center, Worcester, Massachusetts, USA.
authors.forename: L Michael
authors.initials: LM
authors.lastname: Snyder
authors.affiliation: Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.|Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Seth L
authors.identifier: 0000-0002-6228-2512
authors.initials: SL
authors.lastname: Alper
mesh_terms: D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use*; D000745:Anemia, Hemolytic, Congenital / Q000097:blood* / Q000235:genetics; D002452:Cell Count; D004353:Drug Evaluation, Preclinical; D004907:Erythrocyte Deformability; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D000073659:Gain of Function Mutation; D006579:Heterozygote; D006801:Humans; D015160:Hydrops Fetalis / Q000097:blood* / Q000235:genetics; D066298:In Vitro Techniques; D051660:Intermediate-Conductance Calcium-Activated Potassium Channels / Q000037:antagonists & inhibitors* / Q000235:genetics; D017136:Ion Transport / Q000187:drug effects*; D020125:Mutation, Missense; D009996:Osmotic Fragility; D018408:Patch-Clamp Techniques; D011188:Potassium / Q000097:blood*; D026902:Potassium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D014320:Triphenylmethyl Compounds / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000081:Acetamides; D051660:Intermediate-Conductance Calcium-Activated Potassium Channels; C496923:KCNN4 protein, human; D026902:Potassium Channel Blockers; D014320:Triphenylmethyl Compounds; D011188:Potassium; C472774:senicapoc