title: Aedes aegypti Control Through Modernized, Integrated Vector Management.
abstract: In the context of the ongoing, unprecedented Zika virus outbreak in the Americas, the World Health Organization has expressed its support for developing and up-scaling three novel approaches to controlling theAedes aegyptimosquito: the Sterile Insect Technique (SIT), the Release of Insects carrying Dominant Lethal genes (RIDL) and the release ofWolbachia-infected mosquitoes. Whereas the former two approaches are temporary insect population suppression strategies,Wolbachiainfection is a self-sustaining, invasive strategy that uses inherited endosymbiotic bacteria to render natural mosquito populations arbovirus resistant.
  
  
  
  A mathematical model is parameterised with new, Brazilian field data informing the mating competitiveness of mass-reared, released insects; and simulations compare and contrast projections of vector control achieved with the alternative approaches.
  
  
  
  Important disadvantages ofWolbachiaand SIT are identified: both strategies result in mosquitoes ovipositing non-viable eggs and, by alleviating intense larval competition, can cause an overall increase in survival to the adult stage. However, it is demonstrated that strategically combining the suppression methods withWolbachiacan generate a sustained control while mitigating the risks of inadvertent exacerbation of the wild mosquito population.
  
  
  
  This initial analysis demonstrates potential for good synergy when combining novel mosquito approaches in a modernized, integrated vector control programme.
authors.affiliation: Department of Disease Control, The London School of Hygiene & Tropical Medicine, London, United Kingdom.
authors.forename: Laith
authors.initials: L
authors.lastname: Yakob
authors.affiliation: Department of Infectious Disease Epidemiology, The London School of Hygiene & Tropical Medicine, London, United Kingdom.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Funk
authors.affiliation: Department of Infectious Disease Epidemiology, The London School of Hygiene & Tropical Medicine, London, United Kingdom.
authors.forename: Anton
authors.initials: A
authors.lastname: Camacho
authors.affiliation: Department of Infectious Disease Epidemiology, The London School of Hygiene & Tropical Medicine, London, United Kingdom.
authors.forename: Oliver
authors.initials: O
authors.lastname: Brady
authors.affiliation: Department of Infectious Disease Epidemiology, The London School of Hygiene & Tropical Medicine, London, United Kingdom.
authors.forename: W John
authors.initials: WJ
authors.lastname: Edmunds