title: Efficacy and safety of newly developed cross-linked dextran gel injection for glans penis augmentation with a novel technique.
abstract: There is no safe and effective standard method for glans penis augmentation. Furthermore, there has been scant research on glans penis augmentation due to a poor understanding of glans anatomy, technical difficulty, and a lack of suitable substances for augmentation. Cross-linked dextran gel is a newly developed filler for soft-tissue augmentation. We evaluated the efficacy and safety of using a novel technique to inject cross-linked dextran gel for glans penis augmentation during a 24-week follow-up study. This prospective, single-arm, multicenter study enrolled twenty healthy adult men who underwent glans penis augmentation between June and August 2013. Cross-linked dextran gel was injected into the glans penis using a simple and easy technique. The sizes of the glans penis and individual satisfaction were assessed. Any adverse event was also reported. A total of 18 individuals were analyzed; two of them were lost to follow-up. The mean procedure time and injected volume were about 30 min and 6.6 ± 0.9 ml, respectively. The mean surface areas of the glans at baseline and 24 weeks were 20.0 ± 3.5 cm2 and 33.6 ± 5.4 cm2 , respectively, representing a mean increase of 68.7% ± 14.0% (P < 0.001). Sixteen individuals (88.9%) were satisfied with the outcomes, and none were dissatisfied. There were no serious adverse events during the study. Cross-linked dextran gel injection for glans penis augmentation was easy and showed a significant augmentative effect on the glans penis, good durability, and was well tolerated without serious adverse events. Therefore, cross-linked dextran gel injection may be an effective, new technique for glans penis augmentation.
authors.affiliation: Department of Urology, College of Medicine, Hallym University, Chuncheon, Korea.
authors.forename: Dae Yul
authors.initials: DY
authors.lastname: Yang
authors.affiliation: Department of Urology, College of Medicine, Hallym University, Chuncheon, Korea.
authors.forename: Kyungtae
authors.initials: K
authors.lastname: Ko
authors.affiliation: Department of Urology, College of Medicine, Hallym University, Chuncheon, Korea.
authors.forename: Seong Ho
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Urology, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Du Geon
authors.initials: DG
authors.lastname: Moon
authors.affiliation: Department of Urology, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Jong Wook
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Urology, College of Medicine, Hallym University, Chuncheon, Korea.
authors.forename: Won Ki
authors.initials: WK
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D003432:Cross-Linking Reagents; D003911:Dextrans / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010413:Penis / Q000033:anatomy & histology; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003432:Cross-Linking Reagents; D003911:Dextrans; D005782:Gels