title: The Role of ABO Blood Type in Thrombosis Scoring Systems.
abstract: In addition to their major role in transfusion medicine, there is increasing evidence that ABO blood group antigens (complex carbohydrate molecules widely expressed on the surface of red blood cells and several other cell types) are implicated in the development of a wide array of pathologic conditions. In particular, intense research has been dedicated over the last 50 years to the study of the association between non-O blood type and the risk of developing cardiovascular disorders. Several pathways have been hypothesized to explain this relationship, the most reasonable implying the influence of the ABO blood group on circulating plasma levels of von Willebrand factor, factor VIII, and several inflammatory cytokines. This narrative review summarizes the current knowledge on the role of ABO antigens in both venous and arterial thromboses, focusing on their association with clinical scoring systems evaluating thrombotic risk.
authors.affiliation: Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantua, Italy.|Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Marano
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.|Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Vaglio
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Liviana
authors.initials: L
authors.lastname: Catalano
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Pupella
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Giancarlo Maria
authors.initials: GM
authors.lastname: Liumbruno
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D018570:Risk Assessment / Q000379:methods*; D013927:Thrombosis / Q000175:diagnosis*
chemical_list: D000017:ABO Blood-Group System