title: Relation of Thyroid Hormone Levels with Fluid-Resistant Shock among Preterm Septicemic Neonates.
abstract: OBJECTIVE
  To compare thyroid hormone levels between septicemic preterm neonates with and without shock.
  
  
  METHODS
  Preterm septicemic infants with shock constituted Group A (n=36) and those without shock constituted Group B, with groups matched (1:1) for gestation and postnatal age. Those with maternal thyroid disorders, thyrotropic medication and life expectancy <12 hours were excluded. We compared serum tri-iodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) between the groups by univariate and multivariate (adjusting for SNAPPE-II) analysis.
  
  
  RESULTS
  Median (IQR) TSH was significantly lower in Group A [1.39 (0.83,3.48)] vs Group B [5.1 (2.32,7.19)] mmol/dL (P<0.001). Serum T3 and T4 were also lower in Group A (P<0.001). On multivariate analysis, none of these measures were independently associated with septic shock.
  
  
  CONCLUSIONS
  Thyroid hormone levels do not independently predict presence of shock among septic preterms.
authors.affiliation: Departments of Pediatrics and *Nuclear Medicine, PGIMER, Chandigarh, India. Correspondence to: Prof. Sourabh Dutta, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India. sourabhdutta@yahoo.co.in.
authors.forename: Sourabh
authors.initials: S
authors.lastname: Dutta
authors.forename: Sarvendra
authors.initials: S
authors.lastname: Singh
authors.forename: Anish
authors.initials: A
authors.lastname: Bhattacharya
authors.forename: Sundaram
authors.initials: S
authors.lastname: Venkataseshan
authors.forename: Praveen
authors.initials: P
authors.lastname: Kumar
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008297:Male; D018805:Sepsis / Q000097:blood* / Q000150:complications; D012769:Shock / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D013963:Thyroid Hormones / Q000097:blood*
chemical_list: D013963:Thyroid Hormones