title: Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity.
abstract: Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular attention will be paid to the recently described zinc-sensing GPR39 receptor as well as aspects of zinc deficiency. Furthermore, an attempt will be made to give a possible explanation of the mechanisms by which zinc interacts with the monoamine system in the context of depression and neural plasticity.
authors.affiliation: Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland; Department of Animal Physiology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
authors.forename: Urszula
authors.initials: U
authors.lastname: Doboszewska
authors.affiliation: Department of Animal Physiology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Wlaź
authors.affiliation: Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland; Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Kraków, Poland.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Nowak
authors.affiliation: Department of Psychiatry, Medical University of Warsaw, Nowowiejska 27, 00-665 Warszawa, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Radziwoń-Zaleska
authors.affiliation: Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin 130041, China.
authors.forename: Ranji
authors.identifier: 0000-0002-1129-3772
authors.initials: R
authors.lastname: Cui
authors.affiliation: Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
authors.forename: Katarzyna
authors.identifier: 0000-0002-9257-8154
authors.initials: K
authors.lastname: Młyniec
mesh_terms: D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000188:drug therapy* / Q000378:metabolism*; D019587:Dietary Supplements; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D015032:Zinc / Q000008:administration & dosage* / Q000378:metabolism*
chemical_list: D015306:Biogenic Monoamines; D015032:Zinc