title: Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas.
abstract: We isolated a new ellagitannin, davicratinic acid A (5), together with four known ellagitannins, davidiin (1), granatin A (2), pedunculagin (3), and 3-O-galloylgranatin A (4), from an aqueous acetone extract of driedDavidia involucrataleaves. The known ellagitannins were identified based on spectroscopic data. The structure of davicratinic acid A (5), a monomeric ellagitannin possessing a unique, skew-boat glucopyranose core, was established based on spectroscopic data. Additionally, we examined the effects of several tannins with good yields from this plant on drug-resistant bacteria and human oral squamous cell carcinomas, and found that davidiin (1) exhibited the most potent antibacterial and antitumor properties among the tannins examined.
authors.affiliation: Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan. yshimozu@okayama-u.ac.jp.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Shimozu
authors.affiliation: Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan. ph422109@s.okayama-u.ac.jp.
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan. pelp67gx@s.okayama-u.ac.jp.
authors.forename: Akari
authors.initials: A
authors.lastname: Esumi
authors.affiliation: Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan. ph20101@s.okayama-u.ac.jp.
authors.forename: Hiroe
authors.initials: H
authors.lastname: Aoyama
authors.affiliation: Department of Molecular Microbiology and Biotechnology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan. tkuroda@hiroshima-u.ac.jp.
authors.forename: Teruo
authors.initials: T
authors.lastname: Kuroda
authors.affiliation: Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, School of Dentistry, Meikai University, Saitama 350-0283, Japan. sakagami@dent.meikai.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakagami
authors.affiliation: Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan. hatano@pharm.okayama-u.ac.jp.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hatano
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D029767:Cornaceae / Q000737:chemistry*; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D047348:Hydrolyzable Tannins / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D009062:Mouth Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology
chemical_list: D047348:Hydrolyzable Tannins; D010936:Plant Extracts; C013515:ellagitannin
keywords: Davidia involucrata; anti-bacterial effect; antitumor effect; davicratinic acid A; ellagitannin