title: Onychogryphosis in tuberous sclerosis complex: an unusual feature.
abstract: Onychogryphosis is an acquired nail plate change. It often affects the toenail and is characterized by an opaque, yellow-brownish nail plate that is distorted, grossly thickened, elongated, and partly curved resembling a ram's horn. Tuberous sclerosis complex is a multisystem disorder associated with high rates of mental retardation, autism, cognitive impairment, behavioral problems, or seizures. Nail disease can also be associated, which is a concern to patients due to pain and nail distortion. We reported a typical tuberous sclerosis complex patient with distinctive clinical features of a ram's horn nails, which presented a great challenge to surgical treatment and nail restoration.
authors.affiliation: The First Affiliated Hospital to Hebei North University - Zhangjiakou, China.
authors.forename: Xiang-Chun
authors.initials: XC
authors.lastname: Han
authors.affiliation: Chinese People's Liberation Army General Hospital - Beijing, China.|The 251st Hospital of Chinese PLA - Zhangjiakou, China.
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Zheng
authors.affiliation: The 251st Hospital of Chinese PLA - Zhangjiakou, China.
authors.forename: Tie-Gang
authors.initials: TG
authors.lastname: Zheng
mesh_terms: D000368:Aged; D018322:Angiofibroma / Q000000981:diagnostic imaging / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging; D008067:Lipoma / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging; D009260:Nail Diseases / Q000473:pathology*; D009262:Nails / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014402:Tuberous Sclerosis / Q000000981:diagnostic imaging / Q000473:pathology*