title: Wound healing potential of a polyvinyl alcohol-blended pectin hydrogel containing Hippophae rahmnoides L. extract in a rat model.
abstract: In this study, we investigated the effect of a polyvinyl alcohol-blended pectin hydrogel (PVA-PT HG) containing the extracts of Hippophae rhamnoides L. (H. rhamnoides L.) leaves on wound healing in a rat model. The total phenolic content in the extract solution was 40.64±2.7 GAE mg/g and that of flavonoids was 13.15±1.8 QE mg/g. Of the total flavonoids in HGs, 61.6 and 50.0% were released at pH 5.5 and 7.4 after 60min. In rat acute wound models, the wound size was reduced significantly and the recovery rate was significantly higher after treatment with HG containing the extracts, compared with treatment with the control and HG only. The wound healing effects of the HG containing the extracts were confirmed by histological evaluation of the wound tissue. Therefore, HG containing extracts from H. rhamnoides L. leaves enhanced wound healing effectively, and so may be developed as a cover to promote wound healing.
authors.affiliation: Department of Advanced Chemicals and Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
authors.forename: Jin
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, Chonnam National University, Yeosu, Jeonnam 59662, Republic of Korea. Electronic address: cmlee@jnu.ac.kr.
authors.forename: Chang-Moon
authors.initials: CM
authors.lastname: Lee
mesh_terms: D000818:Animals; D005260:Female; D005419:Flavonoids / Q000737:chemistry; D031281:Hippophae / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D010368:Pectins / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D000067996:RAW 264.7 Cells; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D005419:Flavonoids; D020100:Hydrogels; D009569:Nitric Oxide; D010368:Pectins; D011142:Polyvinyl Alcohol
keywords: Flavonoid; Hippophae rhamnoides L.; Hydrogel; Inflammation; Wound healing