title: Acetaminophen use and asthma in children.
abstract: QuestionA child with a history of asthma came to my clinic with acute fever. I have heard that acetaminophen might be associated with exacerbation of asthma. Is it safe if I recommend acetaminophen for this child?AnswerMost studies suggest an association between acetaminophen use in children and development of asthma later in childhood. However, several confounding factors in study design might contribute to this positive correlation, and without a prospective controlled trial, confirming this finding is challenging. If children have a known history of asthma, it is likely safe to administer a single dose of acetaminophen without concern of precipitating adverse respiratory symptoms. Regular use of acetaminophen to relieve fever or pain does not seem to exacerbate asthma in children more than ibuprofen does.
authors.forename: Teeranai
authors.initials: T
authors.lastname: Sakulchit
authors.forename: Ran D
authors.initials: RD
authors.lastname: Goldman
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects*; D000367:Age Factors; D058633:Antipyretics / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007223:Infant; D012307:Risk Factors
chemical_list: D058633:Antipyretics; D000082:Acetaminophen