title: Thrombin-Activatable Fibrinolysis Inhibitor Gene Polymorphism (TAFI1040C/T) in Women With Recurrent Spontaneous Abortion.
abstract: Recurrent spontaneous abortion (RSA) is defined as 3 or more consecutive pregnancy failures. Thrombin-activatable fibrinolysis inhibitor (TAFI) is a plasma zymogen that regulates both fibrinolysis and inflammation. The TAFI 1040C/T polymorphism could alter the circulating levels of TAFI with a reduced capacity to remove the fibrin clots from the circulation; therefore, it could be considered a molecular risk factor for RSA. The TAFI 1040C/T polymorphism was studied in 50 patients with RSA by polymerase chain reaction-restriction fragment length polymorphism technique and compared to 50 age- and gender-matched healthy volunteers as a control group to verify its possible association with RSA. In case group, the wild genotype (C/C) and heterozygous genotype (C/T) did not reduce the risk of RSA (odds ratio: 0.368 and 0.767, respectively), even when compared to the number of RSA ( P = .71). A higher frequency of C allele in the control group and a higher frequency of T allele in the case group were observed but with no statistical significance. In conclusion, our study revealed that TAFI 1040C/T could not be considered a molecular predictive factor for RSA in Egyptians.
authors.affiliation: 1 Department of Clinical and Chemical Pathology, Kasr Al-Ainy Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Nabil
authors.initials: N
authors.lastname: ElDanasori
authors.affiliation: 1 Department of Clinical and Chemical Pathology, Kasr Al-Ainy Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Nelly
authors.initials: N
authors.lastname: Abulata
authors.affiliation: 1 Department of Clinical and Chemical Pathology, Kasr Al-Ainy Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Iman A
authors.initials: IA
authors.lastname: Shaheen
authors.affiliation: 1 Department of Clinical and Chemical Pathology, Kasr Al-Ainy Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Alaa M
authors.initials: AM
authors.lastname: ElGendy
authors.affiliation: 2 Department of Obstetrics and Gynecology, Kasr Al-Ainy Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Waleed
authors.initials: W
authors.lastname: El-Khayat
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D025901:Carboxypeptidase B2 / Q000235:genetics*; D016022:Case-Control Studies; D004534:Egypt; D005260:Female; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D055815:Young Adult
chemical_list: D025901:Carboxypeptidase B2
keywords: PCR-RFLP; TAFI; TAFI 1040C/T gene polymorphism; recurrent spontaneous abortion