title: Modulatory action of 12-O-tetradecanoylphorbol-13-acetate on bud production inHydra.
abstract: A low concentration of 12-O-tetradecanoylphorbol-13-acetate (TPA, 1.0 ng/ml) induced a transient inhibition of bud production in hydra which were fed daily. However, when hydra were starved following TPA-treatment, they produced further buds. Phorbol (1.0 ng/ml) and dimethyl sulfoxide (0.001%) did not influence bud production under either feeding or starvation conditions. These results indicate that TPA modulates asexual reproduction in hydra.
authors.affiliation: Department of Physiology, Hiroshima University School of Dentistry, 734, Hiroshima, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Shiba
keywords: Budding; Hydra; Phorbol; Tumor promoter