title: Differential processing of the direction and focus of expansion of optic flow stimuli in areas MST and V3A of the human visual cortex.
abstract: Human neuropsychological and neuroimaging studies have raised the possibility that different attributes of optic flow stimuli, namely radial direction and the position of the focus of expansion (FOE), are processed within separate cortical areas. In the human brain, visual areas V5/MT+ and V3A have been proposed as integral to the analysis of these different attributes of optic flow stimuli. To establish direct causal relationships between neural activity in human (h)V5/MT+ and V3A and the perception of radial motion direction and FOE position, we used transcranial magnetic stimulation (TMS) to disrupt cortical activity in these areas while participants performed behavioral tasks dependent on these different aspects of optic flow stimuli. The cortical regions of interest were identified in seven human participants using standard functional MRI retinotopic mapping techniques and functional localizers. TMS to area V3A was found to disrupt FOE positional judgments but not radial direction discrimination, whereas the application of TMS to an anterior subdivision of hV5/MT+, MST/TO-2 produced the reverse effects, disrupting radial direction discrimination but eliciting no effect on the FOE positional judgment task. This double dissociation demonstrates that FOE position and radial direction of optic flow stimuli are signaled independently by neural activity in areas hV5/MT+ and V3A.NEW & NOTEWORTHYOptic flow constitutes a biologically relevant visual cue as we move through any environment. With the use of neuroimaging and brain-stimulation techniques, this study demonstrates that separate human brain areas are involved in the analysis of the direction of radial motion and the focus of expansion in optic flow. This dissociation reveals the existence of separate processing pathways for the analysis of different attributes of optic flow that are important for the guidance of self-locomotion and object avoidance.
authors.affiliation: School of Optometry and Vision Science, University of Bradford, Bradford, West Yorkshire, United Kingdom.|York Neuroimaging Centre, Department of Psychology, University of York, York, United Kingdom.
authors.forename: Samantha L
authors.initials: SL
authors.lastname: Strong
authors.affiliation: York Neuroimaging Centre, Department of Psychology, University of York, York, United Kingdom.|Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, Maryland; and.
authors.forename: Edward H
authors.initials: EH
authors.lastname: Silson
authors.affiliation: York Neuroimaging Centre, Department of Psychology, University of York, York, United Kingdom.
authors.forename: André D
authors.initials: AD
authors.lastname: Gouws
authors.affiliation: York Neuroimaging Centre, Department of Psychology, University of York, York, United Kingdom.|Centre for Neuroscience, Hull-York Medical School, University of York, York, United Kingdom.
authors.forename: Antony B
authors.initials: AB
authors.lastname: Morland
authors.affiliation: School of Optometry and Vision Science, University of Bradford, Bradford, West Yorkshire, United Kingdom; d.mckeefry@bradford.ac.uk.
authors.forename: Declan J
authors.initials: DJ
authors.lastname: McKeefry
mesh_terms: D000328:Adult; D004192:Discrimination, Psychological / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009039:Motion Perception / Q000502:physiology; D057849:Optic Flow / Q000502:physiology*; D010775:Photic Stimulation; D011601:Psychophysics; D050781:Transcranial Magnetic Stimulation; D014793:Visual Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D055815:Young Adult
keywords: V3A; V5/MT+; fMRI; psychophysics; transcranial magnetic stimulation