title: Behavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal.
abstract: Purpose To evaluate the polymer doped rods behavior with bioactive glass and hydroxyapatite for possible application as a fracture fixing method. Methods Twenty eight Rattus norvegicus Wistar underwent bone defect for access to the femoral medullary canal and distributed into three experimental groups: group A - doped castor bean polymer with bioactive glass; group B - castor bean polymer and; group C - castor bean polymer doped with bioactive glass and hydroxyapatite. After 15 and 60 evaluation days, the femurs were removed and sent for histology and scanning electron microscopy. Results Initially mild and moderate inflammatory infiltrate is observed that decreases as time goes by, and the presence of connective tissue capsule around the graft in all groups. Regarding the biomaterials resorption little was observed. The implanted rods did not favor the osteoconductive process in the femoral medullary canal which was observed only in the C15 group. Conclusions The association of castor bean polymer, bioactive glass and hydroxyapatite was biocompatible and osteointegrable. The osteoconductive only occurred in the presence of hydroxyapatite and bioactive glass (C15 Group) and little biodegradation was observed.
authors.affiliation: Postgraduate Program in Health and Development, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Viviani Teixeira Dos
authors.initials: VT
authors.lastname: Santos
authors.affiliation: Universidade Anhanguera-Uniderp, Campo Grande, MS, Brazil.
authors.forename: Gilberto Gonçalves
authors.initials: GG
authors.lastname: Facco
authors.affiliation: Postgraduate Program in Health and Development, UFMS, Campo Grande, MS, Brazil.
authors.forename: Hudman Cunha
authors.initials: HC
authors.lastname: Ortiz
authors.affiliation: Postgraduate Program in Health and Development, UFMS, Campo Grande, MS, Brazil.
authors.forename: Iandara Schettert da
authors.initials: IS
authors.lastname: Silva
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D001861:Bone Regeneration; D002368:Castor Oil / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry / Q000627:therapeutic use*; D005269:Femur; D005593:Fracture Fixation, Internal / Q000379:methods*; D005898:Glass / Q000737:chemistry*; D016268:Internal Fixators; D023421:Models, Animal; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001672:Biocompatible Materials; D002368:Castor Oil; D017886:Durapatite