title: The Effect of Locally Administered Pamidronate on Autogenous Bone Graft in Maxillofacial Reconstruction: A Randomized Clinical Trial.
abstract: BACKGROUND
  Although bone grafts are commonly used in reconstructive surgeries, they are sensitive to local perfusion and are thus prone to severe resorption. Biphosphonates can inactivate osteoclasts and can be used to control the undesirable bone resorption.
  
  
  OBJECTIVE
  To assess the effect of administration of biphosphonates on bone resorption.
  
  
  METHODS
  20 patients with bony defects who were candidates for free autogenous grafts were randomized into "pamidronate" and "control" groups. Bone segments were soaked in either pamidronate solution or normal saline and were inserted into the area of the surgery. Bone densities were measured post-surgery and in 6-month follow-up. Data were obtained via Digora software and analyzed.
  
  
  RESULTS
  The mean±SD bone density in pamidronate group changed from 93.4±14.6 to 93.6±17.5 (p<0.05); in the control group the density decreased from 89.7±13.2 to 78.9±11.4 (p<0.05). The mean difference of bone density in anterior areas of the jaws showed higher DXA in comparison to posterior regions (p=0.002).
  
  
  CONCLUSIONS
  Locally administered pamidronate affects reduction in bone resorption.
authors.affiliation: Craniomaxillofacial Research center, Tehran University of Medical Sciences, Tehran, Iran; Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Bayat
authors.affiliation: Craniomaxillofacial Research center, Tehran University of Medical Sciences, Tehran, Iran; Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Garajei
authors.affiliation: Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: E
authors.initials: E
authors.lastname: Afshari Pour
authors.affiliation: Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Hasheminasab
authors.affiliation: Department of Physiology, Islamic Azad University, Tehran, Iran.
authors.forename: Y
authors.initials: Y
authors.lastname: Ghorbani
authors.affiliation: Oral and Maxillofacial Surgery, Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Attending Faculty, Department of Oral and Maxillofacial Surgery, Azad University of Medical Sciences, Dental College, Tehran, Iran.
authors.forename: M H
authors.initials: MH
authors.lastname: Kalantar Motamedi
authors.affiliation: Craniomaxillofacial Research center, Tehran University of Medical Sciences, Tehran, Iran; Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran; Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Bahrami
keywords: Bone transplantation; Oral surgical procedures; Pamidronate [supplementary concept]; Reconstructive surgical procedures