title: Peptides from gluten digestion: A comparison between old and modern wheat varieties.
abstract: Coeliac disease is an autoimmune enteropathy that develops in genetically predisposed subjects after the ingestion of gluten or related proteins. Coeliac disease has an increasing incidence in the last years in western countries and it has been suggested that wheat breeding might have contributed to select more toxic forms of gluten. In this work, we analysed gluten peptides generated by in vitro digestion of different old and modern Triticum varieties, using LC-MS. We concluded that old varieties analysed produced a higher quantity of peptides containing immunogenic and toxic sequences than modern ones. Thus old wheat lines are not to be considered "safer" for subjects that are genetically predisposed to celiac disease.
authors.affiliation: Department of Food Science, University of Parma, Parco Area delle Scienze 59/A, 43124, Italy. Electronic address: barbara.prandi@unipr.it.
authors.forename: Barbara
authors.initials: B
authors.lastname: Prandi
authors.affiliation: Department of Food Science, University of Parma, Parco Area delle Scienze 59/A, 43124, Italy.
authors.forename: Tullia
authors.initials: T
authors.lastname: Tedeschi
authors.affiliation: Open Fields S.R.L., Strada Consortile 2, 43044 Collecchio, PR, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Folloni
authors.affiliation: Department of Food Science, University of Parma, Parco Area delle Scienze 59/A, 43124, Italy.
authors.forename: Gianni
authors.initials: G
authors.lastname: Galaverna
authors.affiliation: Department of Food Science, University of Parma, Parco Area delle Scienze 59/A, 43124, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Sforza
mesh_terms: D002446:Celiac Disease / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D004063:Digestion; D020022:Genetic Predisposition to Disease; D005983:Glutens / Q000009:adverse effects / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D016056:Immunodominant Epitopes; D010446:Peptide Fragments / Q000009:adverse effects / Q000276:immunology / Q000378:metabolism*; D010449:Peptide Mapping / Q000379:methods; D018570:Risk Assessment; D012307:Risk Factors; D014908:Triticum / Q000009:adverse effects / Q000145:classification / Q000276:immunology / Q000378:metabolism*
chemical_list: D016056:Immunodominant Epitopes; D010446:Peptide Fragments; D005983:Glutens
keywords: Coeliac disease; Gluten peptides; In vitro digestion; Old wheat; Wheat breeding