title: [Nonplatelet Effects of Ticagrelor].
abstract: This review summarizes current knowledge concerning "nonplatelet effects of P2Y12 receptor antagonist ticagrelor. We show the experimental and clinical evidence that ticagrelor increases plasma concentration of adenosine as a potential mechanism of additive effects of ticagrelor. In addition, we sought to compare the clinical profile of ticagrelor with pharmacological effects of adenosine and discuss from this point of view the effects of ticagrelor on vascular tone, cardiac electrophysiology, ischemia/reperfusion injury, immunity and inflammatory reactions, peripheral nerves.
authors.affiliation: Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Complex, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Boiko
authors.affiliation: Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Complex, Moscow, Russia.
authors.forename: G N
authors.initials: GN
authors.lastname: Soboleva
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D001341:Autonomic Nervous System / Q000187:drug effects; D006801:Humans; D007109:Immunity / Q000187:drug effects; D017202:Myocardial Ischemia / Q000188:drug therapy; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D058921:Purinergic P2Y Receptor Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000077486:Ticagrelor; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D010975:Platelet Aggregation Inhibitors; D058921:Purinergic P2Y Receptor Antagonists; D000077486:Ticagrelor; D000241:Adenosine
keywords: adenosine; nonplatelet effects of ticagrelor; ticagrelor