title: TREM1: A Potential Therapeutic Target For Alzheimer's Disease.
abstract: Immunity has been suggested to play crucial roles in the pathogenesis of Alzheimer's disease (AD). The triggering receptor expressed on myeloid cells-1 (TREM1), a member of the immunoglobulin superfamily of receptors, is widely expressed in monocytes and microglia. On the other hand, TREM1 variant, rs6910730G, is reported to associate with AD pathology; however, the exact mechanism is not yet clear. Since phagocytosis of Aβ by monocytes enhances Aβ clearance and attenuates AD pathogenesis, Jiang et al. has investigated if TREM1 can modulate Aβ phagocytosis and degradation by monocytes in the central nervous system (CNS). They found that TREM1 facilitates microglial Aβ phagocytosis while rs6910730Gimpairs this function and exacerbates AD pathogenesis. These findings suggest that TREM1 can be implemented investigated as a potential therapeutic target in AD.
authors.affiliation: Department of Cell Biology, Physiology & Neuroscience, Skirball Institute of Bimolecular Medicine, New York University Langone Medical Center, New York, NY, 10016, USA. khalil.saadipour@nyumc.org.
authors.forename: Khalil
authors.initials: K
authors.lastname: Saadipour
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D010587:Phagocytosis / Q000187:drug effects; D000073871:Triggering Receptor Expressed on Myeloid Cells-1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
keywords: Alzheimer’s disease; Amyloid beta; Microglia; Phagocytosis; TREM1; rs6910730G