title: Association between glucose intolerance and bacterial colonisation in an adult population with cystic fibrosis, emergence of Stenotrophomonas maltophilia.
abstract: BACKGROUND
  Diabetes is common in cystic fibrosis (CF). Glucose can be detected in the airway when the blood glucose is elevated, which favours bacterial growth. We investigated the relationship between dysglycemia and lung pathogens in CF.
  
  
  METHODS
  Cross-sectional and prospective analysis of CF patients (N=260) who underwent a 2h-oral glucose tolerance test. Clinical data was collected.
  
  
  RESULTS
  Stenotrophomonas maltophilia (S. maltophilia) was the sole bacteria increased in dysglycemic (AGT: 20.2%, CFRD: 21.6%) patients compared to normotolerants (NGT: 8.7%). S. maltophilia positive patients with dysglycemia had more pulmonary exacerbation events compared to NGTs (1.22 vs 0.63, P=0.003). The interaction between S. maltophilia colonisation and glucose tolerance status significantly increases the risk of lower lung function (P=0.003). Its growth was not affected by the evolution of the glucose tolerance after three years follow-up.
  
  
  CONCLUSIONS
  Prevalence of S. maltophilia was higher in dysglycemic patients, supporting the idea that S. maltophilia is a marker of disease severity in CF.
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec H3T 1A8, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Lehoux Dubois
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec H3T 1A8, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Boudreau
authors.affiliation: Department of Medecine, Université de Montréal, Montréal, Québec H3T 1J4, Canada; Cystic Fibrosis Clinic of the Centre hospitalier de l'Université de Montréal, Montréal, Québec H2W 1T8, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Tremblay
authors.affiliation: Department of Medecine, Université de Montréal, Montréal, Québec H3T 1J4, Canada; Cystic Fibrosis Clinic of the Centre hospitalier de l'Université de Montréal, Montréal, Québec H2W 1T8, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Lavoie
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Medecine, Université de Montréal, Montréal, Québec H3T 1J4, Canada; Cystic Fibrosis Clinic of the Centre hospitalier de l'Université de Montréal, Montréal, Québec H2W 1T8, Canada.
authors.forename: Y
authors.initials: Y
authors.lastname: Berthiaume
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec H3T 1A8, Canada; Department of Medecine, Université de Montréal, Montréal, Québec H3T 1J4, Canada; Cystic Fibrosis Clinic of the Centre hospitalier de l'Université de Montréal, Montréal, Québec H2W 1T8, Canada. Electronic address: remi.rabasa-lhoret@ircm.qc.ca.
authors.forename: R
authors.initials: R
authors.lastname: Rabasa-Lhoret
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Coriati
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002170:Canada / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000097:blood / Q000382:microbiology / Q000503:physiopathology; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis / Q000382:microbiology; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012137:Respiratory System / Q000382:microbiology*; D012141:Respiratory Tract Infections / Q000097:blood / Q000453:epidemiology / Q000382:microbiology; D012720:Severity of Illness Index; D013223:Statistics as Topic; D020615:Stenotrophomonas maltophilia / Q000302:isolation & purification*
chemical_list: D001786:Blood Glucose
keywords: Cystic fibrosis; Cystic fibrosis related diabetes; Infections; Pathogens; Pulmonary exacerbations; Stenotrophomonas maltophilia