title: Oral health in relation to all-cause mortality: the IPC cohort study.
abstract: We evaluated the association between oral health and mortality. The study population comprised 76,188 subjects aged 16-89 years at recruitment. The mean follow-up time was 3.4 ± 2.4 years. Subjects with a personal medical history of cancer or cardiovascular disease and death by casualty were excluded from the analysis. A full-mouth clinical examination was performed in order to assess dental plaque, dental calculus and gingival inflammation. The number of teeth and functional masticatory units <5 were recorded. Causes of death were ascertained from death certificates. Mortality risk was evaluated using Cox regression model with propensity score calibrated for each oral exposure. All-cause mortality risk were raised with dental plaque, gingival inflammation, >10 missing teeth and functional masticatory units <5. All-cancer mortality was positively associated with dental plaque and gingival inflammation. Non-cardiovascular and non-cancer mortality were also positively associated with high dental plaque (HR = 3.30, [95% CI: 1.76-6.17]), high gingival inflammation (HR = 2.86, [95% CI: 1.71-4.79]), >10 missing teeth (HR = 2.31, [95% CI: 1.40-3.82]) and functional masticatory units <5 (HR = 2.40 [95% CI 1.55-3.73]). Moreover, when ≥3 oral diseases were cumulated in the model, the risk increased for all-cause mortality (HR = 3.39, [95% CI: 2.51-5.42]), all-cancer mortality (HR = 3.59, [95% CI: 1.23-10.05]) and non-cardiovascular and non-cancer mortality (HR = 4.71, [95% CI: 1.74-12.7]). The present study indicates a postive linear association between oral health and mortality.
authors.affiliation: Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7-Denis Diderot University, U.F.R. of Odontology, Paris, France.
authors.forename: Margaux
authors.initials: M
authors.lastname: Adolph
authors.affiliation: Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7-Denis Diderot University, U.F.R. of Odontology, Paris, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Darnaud
authors.affiliation: Centre d'Investigation Préventive et Clinique (IPC), Paris, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Thomas
authors.affiliation: Centre d'Investigation Préventive et Clinique (IPC), Paris, France.|Manhès Hospital, Fleury-Mérogis, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Pannier
authors.affiliation: Centre d'Investigation Préventive et Clinique (IPC), Paris, France.|Department of Cardiology, Georges Pompidou European Hospital, AP-HP, Paris 5 - Descartes University, Medicine Faculty, Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Danchin
authors.affiliation: Department of Epidemiology and Public Health, University College London, London, UK.
authors.forename: G David
authors.initials: GD
authors.lastname: Batty
authors.affiliation: Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7-Denis Diderot University, U.F.R. of Odontology, Paris, France.|EA 2496, Paris 5 - Descartes University, U.F.R. of Odontology, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bouchard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000150:complications / Q000401:mortality* / Q000473:pathology; D003773:Dental Plaque / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D005260:Female; D005891:Gingivitis / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000150:complications / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D009369:Neoplasms / Q000150:complications / Q000401:mortality* / Q000473:pathology; D009909:Oral Health; D016016:Proportional Hazards Models