title: Patterns of Default Mode Network Deactivation in Obsessive Compulsive Disorder.
abstract: The objective of the present study was to research the patterns of Default Mode Network (DMN) deactivation in Obsessive Compulsive Disorder (OCD) in the transition between a resting and a non-rest emotional condition. Twenty-seven participants, 15 diagnosed with OCD and 12 healthy controls (HC), underwent a functional neuroimaging paradigm in which DMN brain activation in a resting condition was contrasted with activity during a non-rest condition consisting in the presentation of emotionally pleasant and unpleasant images. Results showed that HC, when compared with OCD, had a significant deactivation in two anterior nodes of the DMN (medial frontal and superior frontal) in the non-rest pleasant stimuli condition. Additional analysis for the whole brain, contrasting the resting condition with all the non-rest conditions grouped together, showed that, compared with OCD, HC had a significantly deactivation of a widespread brain network (superior frontal, insula, middle and superior temporal, putamen, lingual, cuneus, and cerebellum). Concluding, the present study found that OCD patients had difficulties with the deactivation of DMN even when the non-rest condition includes the presentation of emotional provoking stimuli, particularly evident for images with pleasant content.
authors.affiliation: Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal.|Spaulding Neuromodulation Center, Department of Physical Medicine &Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.|Department of Applied Psychology, Northeastern University, Boston, USA.
authors.forename: Óscar F
authors.initials: ÓF
authors.lastname: Gonçalves
authors.affiliation: Life and Health Sciences Research Institute, University of Minho, Braga, Portugal.|ICVS-3Bs PT Government Associate Laboratory, Braga/Guimarães, Portugal.
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Soares
authors.affiliation: Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal.|Spaulding Neuromodulation Center, Department of Physical Medicine &Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Sandra
authors.initials: S
authors.lastname: Carvalho
authors.affiliation: Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal.|Spaulding Neuromodulation Center, Department of Physical Medicine &Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Jorge
authors.initials: J
authors.lastname: Leite
authors.affiliation: Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Ganho-Ávila
authors.affiliation: CUF Porto Hospital, Department of Psychiatry, Porto, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Fernandes-Gonçalves
authors.affiliation: Department of Psychiatry, University of Coimbra Hospitals, Coimbra, Portugal.
authors.forename: Fernando
authors.initials: F
authors.lastname: Pocinho
authors.affiliation: Forensic Genetics Unit, Institute of Legal Medicine, Faculty of Medicine, University of Santiago de Compostela, Galicia, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Carracedo
authors.affiliation: Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal.
authors.forename: Adriana
authors.initials: A
authors.lastname: Sampaio
mesh_terms: D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000503:physiopathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004644:Emotions / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D010364:Pattern Recognition, Visual / Q000502:physiology; D010781:Photography; D011699:Putamen / Q000000981:diagnostic imaging / Q000503:physiopathology; D012146:Rest / Q000502:physiology; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*