title: A molecular marker for epithelial morphogenesis in the cockroach.
abstract: A molecular marker has been identified in embryos of the cockroach, Periplaneta americana, that is localized among epithelial cells to those directly involved in morphogenesis. A monoclonal antibody has been developed that selectively binds to epithelial cells undergoing any of three very different morphogenetic movements-invagination, evagination or epiboly. Neighboring cells not involved in these developmental processes are not labeled by the antibody. The antigen is transiently present on the cells for a period just prior to and during the morphogenetic activity. It is localized on the apical surface of the cells. The spatial, temporal and subcellular distributions of antibody binding during development indicate a role for the antigen in epithelial morphogenesis different from that of any previously described molecule.
authors.affiliation: Biology Department, University of Iowa, 52242, Iowa City, Iowa, USA.
authors.forename: Betty A
authors.initials: BA
authors.lastname: Norbeck
authors.affiliation: Biology Department, University of Iowa, 52242, Iowa City, Iowa, USA.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Denburg
keywords: Cockroach; Epithelial morphogenesis; Molecular marker; Monoclonal antibody; Morphogenesis