title: Risk Factors for Central Serous Chorioretinopathy: Multivariate Approach in a Case-Control Study.
abstract: The purpose of this prospective study was to investigate the potential risk factors associated independently with central serous retinopathy (CSR) in a Greek population, using multivariate approach.
  
  
  
  Participants in the study were 183 consecutive patients diagnosed with CSR and 183 controls, matched for age. All participants underwent complete ophthalmological examination and information regarding their sociodemographic, clinical, medical and ophthalmological history were recorded, so as to assess potential risk factors for CSR. Univariate and multivariate analysis was performed.
  
  
  
  Univariate analysis showed that male sex, high educational status, high income, alcohol consumption, smoking, hypertension, coronary heart disease, obstructive sleep apnea, autoimmune disorders, H. pylori infection, type A personality and stress, steroid use, pregnancy and hyperopia were associated with CSR, while myopia was found to protect from CSR. In multivariate analysis, alcohol consumption, hypertension, coronary heart disease and autoimmune disorders lost their significance, while the remaining factors were all independently associated with CSR.
  
  
  
  It is important to take into account the various risk factors for CSR, so as to define vulnerable groups and to shed light into the pathogenesis of the disease.
authors.affiliation: a 2nd Department of Ophthalmology , Ophthalmiatrion Athinon , Athens , Greece.
authors.forename: Irini
authors.initials: I
authors.lastname: Chatziralli
authors.affiliation: b Medical Retina Department , Korgialeneio Benakeio, Red Cross Hospital , Athens , Greece.
authors.forename: Stamatina A
authors.initials: SA
authors.lastname: Kabanarou
authors.affiliation: a 2nd Department of Ophthalmology , Ophthalmiatrion Athinon , Athens , Greece.
authors.forename: Efstratios
authors.initials: E
authors.lastname: Parikakis
authors.affiliation: a 2nd Department of Ophthalmology , Ophthalmiatrion Athinon , Athens , Greece.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Chatzirallis
authors.affiliation: b Medical Retina Department , Korgialeneio Benakeio, Red Cross Hospital , Athens , Greece.
authors.forename: Tina
authors.initials: T
authors.lastname: Xirou
authors.affiliation: a 2nd Department of Ophthalmology , Ophthalmiatrion Athinon , Athens , Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Mitropoulos
mesh_terms: D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006115:Greece / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D014792:Visual Acuity
keywords: Central serous chorioretinopathy; hypertension; multivariate; myopia; risk factors; stress