title: Predictors of tobacco abstinence in outpatient smokers with schizophrenia or bipolar disorder treated with varenicline and cognitive behavioral smoking cessation therapy.
abstract: The estimated mortality gap between those with and without serious mental illness (SMI) is increasing, now estimated at 28years, which is largely due to smoking-related diseases.
  
  
  
  We sought to identify predictors of 14-day continuous abstinence in stable outpatient smokers with SMI.
  
  
  
  Adult smokers with schizophrenia spectrum (n=130) or bipolar disorder (n=23) were enrolled in a 12-week course of varenicline and cognitive-behavioral therapy for smoking cessation.
  
  
  
  Independent predictors of abstinence included reduction in withdrawal symptoms prior to the quit day, fewer cigarettes smoked per day at baseline, better baseline attention, remitted alcohol dependence, and lower expectation of peer support to aid quitting.
  
  
  
  Interventions that consider these targets may improve smoking cessation outcomes in those with SMI.
authors.affiliation: Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States.
authors.forename: Randi M
authors.initials: RM
authors.lastname: Schuster
authors.affiliation: Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States. Electronic address: ccather@mgh.harvard.edu.
authors.forename: Corinne
authors.initials: C
authors.lastname: Cather
authors.affiliation: Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States.
authors.forename: Gladys N
authors.initials: GN
authors.lastname: Pachas
authors.affiliation: Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, United States; MGH Biostatistics Center, United States; Harvard T.H. Chan School of Public Health, United States.
authors.forename: Haiyue
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States.
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Cieslak
authors.affiliation: Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States.
authors.forename: Susanne S
authors.initials: SS
authors.lastname: Hoeppner
authors.affiliation: Harvard Medical School, United States; MGH Biostatistics Center, United States; Harvard T.H. Chan School of Public Health, United States.
authors.forename: David
authors.initials: D
authors.lastname: Schoenfeld
authors.affiliation: Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, United States.
authors.forename: A Eden
authors.initials: AE
authors.lastname: Evins
mesh_terms: D001288:Attention; D001714:Bipolar Disorder / Q000453:epidemiology*; D015928:Cognitive Behavioral Therapy; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018722:Nicotinic Agonists / Q000627:therapeutic use; D010045:Outpatients / Q000523:psychology / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000453:epidemiology*; D000074285:Smokers / Q000523:psychology / Q000706:statistics & numerical data; D016540:Smoking Cessation / Q000379:methods / Q000523:psychology / Q000706:statistics & numerical data*; D013375:Substance Withdrawal Syndrome; D014029:Tobacco Use Disorder / Q000453:epidemiology* / Q000628:therapy; D000068580:Varenicline / Q000627:therapeutic use*
chemical_list: D018722:Nicotinic Agonists; D000068580:Varenicline
keywords: Abstinence; Bipolar; Nicotine; Predictors; Schizophrenia; Smoking cessation; Varenicline