title: The clinical significance of Epstein-Barr virus DNA in peripheral blood mononuclear cells in patients with non-Hodgkin lymphoma.
abstract: The aim of the study was to determine the clinical significance of EBV DNA in the peripheral blood mononuclear cells (PBMCs) from the patients with non-Hodgkin lymphoma (NHL). Newly diagnosed patients with NHL were enrolled in the study (n = 328), and clinical data retrospectively analyzed. EBV DNA was detectable in 34.8% of patients, and the positivity rate was 51.6% for T/NK cell subtype and 24.3% for B cell subtype (p < .001). In diffuse large B cell lymphoma (DLBCL), extranodal NK/T-cell lymphoma, nasal type (ENKTL), peripheral T-cell lymphoma not otherwise classified (PTCL.NOS), or angioimmunoblastic T cell lymphoma (AITL), positive EBV DNA before treatment was associated with more risk factors with prognostic significance, including older age, advanced stage, extranodal involvement, bone marrow infiltration, elevated LDH, and B symptoms, and with poor prognosis.
authors.affiliation: a Fujian Provincial Key Laboratory on Hematology , Fujian Medical University Union Hospital, Fujian Institute of Hematology , Fuzhou , Fujian , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: a Fujian Provincial Key Laboratory on Hematology , Fujian Medical University Union Hospital, Fujian Institute of Hematology , Fuzhou , Fujian , China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Zheng
authors.affiliation: a Fujian Provincial Key Laboratory on Hematology , Fujian Medical University Union Hospital, Fujian Institute of Hematology , Fuzhou , Fujian , China.
authors.forename: Buyuan
authors.initials: B
authors.lastname: Chen
authors.affiliation: a Fujian Provincial Key Laboratory on Hematology , Fujian Medical University Union Hospital, Fujian Institute of Hematology , Fuzhou , Fujian , China.
authors.forename: Xiaozhu
authors.initials: X
authors.lastname: Yang
authors.affiliation: a Fujian Provincial Key Laboratory on Hematology , Fujian Medical University Union Hospital, Fujian Institute of Hematology , Fuzhou , Fujian , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zheng
authors.affiliation: a Fujian Provincial Key Laboratory on Hematology , Fujian Medical University Union Hospital, Fujian Institute of Hematology , Fuzhou , Fujian , China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: a Fujian Provincial Key Laboratory on Hematology , Fujian Medical University Union Hospital, Fujian Institute of Hematology , Fuzhou , Fujian , China.
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.affiliation: a Fujian Provincial Key Laboratory on Hematology , Fujian Medical University Union Hospital, Fujian Institute of Hematology , Fuzhou , Fujian , China.
authors.forename: Tingbo
authors.initials: T
authors.lastname: Liu
authors.affiliation: a Fujian Provincial Key Laboratory on Hematology , Fujian Medical University Union Hospital, Fujian Institute of Hematology , Fuzhou , Fujian , China.
authors.forename: Jianda
authors.initials: J
authors.lastname: Hu
mesh_terms: D004279:DNA, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000150:complications; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007119:Immunoblastic Lymphadenopathy; D007963:Leukocytes, Mononuclear; D054391:Lymphoma, Extranodal NK-T-Cell / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000821:virology; D012189:Retrospective Studies
chemical_list: D004279:DNA, Viral
keywords: Epstein-Barr virus; clinical features; non-Hodgkin lymphoma; prognosis