title: Prospective study of factors important to achieve observation of the entire colon on colon capsule endoscopy.
abstract: BACKGROUND
  Colon capsule endoscopy (CCE) is a procedure in which capsule swallowing facilitates observation of the lumen of the entire digestive tract. It does not require an air supply, and is a noninvasive procedure with a markedly low risk of adverse events in comparison with conventional colonoscopy (CS). It reduces patient stress, and may be acceptable to patients. A limitation of this procedure is that the entire colon observation rate (CCE excretion rate, completed CCE rate) is not 100%. In this study, we prospectively investigated clinical factors important to achieve observation of the entire colon on CCE.
  
  
  METHODS
  The participants were 70 patients for whom CCE was scheduled, and from whom written informed consent regarding participation in this study was obtained. We selected patient background/examination factors, and analyzed all factors involved in observation of the entire colon and factors for completion of the CCE within 4 h after the start of examination using multivariate analysis.
  
  
  RESULTS
  Of the 70 enrolled patients, 64 were analyzed, excluding 6. On multiple logistic analysis, only a water intake of ⩾12.0 ml/min during examination [p= 0.025, odds ratio (OR): 46.753, 95% confidence interval (CI): 1.630-1341.248] was identified as an independent predictive factor involved in observation of the entire colon. With respect to factors involved in the completion of CCE within 4 h, multiple logistic analysis showed that a body mass index (BMI) of ⩾25 (p= 0.039, OR: 13.723, 95% CI: 1.135-165.913), the absence of constipation (p= 0.030, OR: 13.988, 95% CI: 1.287-152.047), and a water intake of ⩾12.0 ml/min during examination (p= 0.004, OR: 12.028, 95% CI: 2.225-65.029) were independent predictive factors.
  
  
  CONCLUSIONS
  Completion of a CCE was most closely related to water intake per hour. In addition to water intake, CCE-promoting factors included a high BMI and the absence of constipation.
authors.affiliation: Nagoya University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Nagoya, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Sato
authors.affiliation: Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
authors.forename: Masanao
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Nagoya University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Nagoya, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Watanabe
authors.affiliation: Nagoya University Hospital, Department of Endoscopy, Nagoya, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamamura
authors.affiliation: Nagoya University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Nagoya, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Funasaka
authors.affiliation: Nagoya University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Nagoya, Japan.
authors.forename: Eizaburo
authors.initials: E
authors.lastname: Ohno
authors.affiliation: Nagoya University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Nagoya, Japan.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Miyahara
authors.affiliation: Nagoya University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Nagoya, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kawashima
authors.affiliation: Nagoya University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Nagoya, Japan.
authors.forename: Hidemi
authors.initials: H
authors.lastname: Goto
authors.affiliation: Nagoya University Hospital, Department of Endoscopy, Nagoya, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hirooka
keywords: body mass index; capsule endoscopy; colon; constipation; gastrointestinal endoscopy; water intake