title: [Molecular-allergological aspects of allergen-specific immunotherapy].
abstract: Allergen-specific immunotherapy (SIT) does not achieve 100% efficacy, nor is there a reliable marker for therapy failure. However, advances in molecular allergology over the past few years have allowed a significantly improved characterization of the patients using molecular-allergological analysis methods (molecular phenotyping). Thus, major and minor allergens can be identified. In addition, the marker allergens for the severity of an allergic reaction, the pathological and therapeutic predictive marker allergens, and sensitization patterns are identified.
authors.affiliation: Forschungsgruppe Klinische und Molekulare Allergologie, Forschungszentrum Borstel, Parkallee 35, 23845, Borstel, Deutschland. ujappe@fz-borstel.de.|Interdisziplinäre Allergieambulanz, Medizinische Klinik III, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Deutschland. ujappe@fz-borstel.de.
authors.forename: Uta
authors.initials: U
authors.lastname: Jappe
mesh_terms: D000485:Allergens / Q000276:immunology* / Q000627:therapeutic use*; D000818:Animals; D016207:Cytokines / Q000276:immunology*; D003888:Desensitization, Immunologic / Q000379:methods*; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*
chemical_list: D000485:Allergens; D016207:Cytokines
keywords: Biomarker; Desensitization, immunologic; Major allergens; Marker allergens; Minor allergens