title: Quantitative study of regression and regeneration of the thymic cell population after X-irradiation in the newtPleurodeles waltlii Michah.
abstract: The changes in cell numbers of different thymic cell populations and the conditions governing the regeneration of these populations and the thymus itself were examined after X-irradiation (700 rads) of different parts of the body. The general effects of the irradiation were studied in each experimental group in terms of mortality and growth rate. The particular effects on each thymic cell population were studied by the measurement of mitotic activity and of evaluation of the changes in numbers among these populations in the thymus itself, and were compared with the effects in the granulopoietic layer of the liver and in the spleen. The great reduction in the number of lymphocytes after irradiation demonstrates that they are more radiosensitive than other cell types; this reduction can be compensated for by the arrival of new lymphoid cells originating from other lymphoid organs (if they have been protected from irradiation) and by allowing thymic regeneration. Thus, irradiation has indirect effects on non-irradiated areas, and demonstrates that the lymphoid cell population has a high potential for multidirectional migration.
authors.affiliation: Laboratoire de Zoologie et Biologie animale, Université scientifique et médicale de Grenoble, B.P. 68, F-38402, Saint-Martin-d'Hères Cedex, France.
authors.forename: Yehia
authors.initials: Y
authors.lastname: Moustafa
authors.affiliation: Laboratoire de Zoologie et Biologie animale, Université scientifique et médicale de Grenoble, B.P. 68, F-38402, Saint-Martin-d'Hères Cedex, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Chibon
keywords: Irradiation; Lymphoid cells; Regeneration; Thymus