title: Testosterone therapy has positive effects on anthropometric measures, metabolic syndrome components (obesity, lipid profile, Diabetes Mellitus control), blood indices, liver enzymes, and prostate health indicators in elderly hypogonadal men.
abstract: To alleviate late-onset hypogonadism, testosterone treatment is offered to suitable patients. Although testosterone treatment is commonly given to late-onset hypogonadism patients, there remains uncertainty about the metabolic effects during follow-ups. We assessed the associations between testosterone treatment and wide range of characteristics that included hormonal, anthropometric, biochemical features. Patients received intramuscular 1,000 mg testosterone undecanoate for 1 year. Patient anthropometric measurements were undertaken at baseline and at each visit, and blood samples were drawn at each visit, prior to the next testosterone undecanoate. Eighty-eight patients (51.1 ± 13.0 years) completed the follow-up period. Testosterone treatment was associated with significant increase in serum testosterone levels and significant stepladder decrease in body mass index, total cholesterol, triglycerides and glycated haemoglobin from baseline values among all patients. There was no significant increase in liver enzymes. There was an increase in haemoglobin and haematocrit, as well as in prostate-specific antigen and prostate volume, but no prostate biopsy intervention was needed for study patients during 1-year testosterone treatment follow-up. Testosterone treatment with long-acting testosterone undecanoate improved the constituents of metabolic syndrome and improved glycated haemoglobin in a stepladder fashion, with no adverse effects.
authors.affiliation: Department of Urology & Andrology, Hamad General Hospital, Doha, Qatar.
authors.forename: O
authors.initials: O
authors.lastname: Canguven
authors.affiliation: Department of Urology & Andrology, Hamad General Hospital, Doha, Qatar.
authors.forename: R A
authors.initials: RA
authors.lastname: Talib
authors.affiliation: Department of Surgery, Hamad General Hospital, Doha, Qatar.
authors.forename: W
authors.initials: W
authors.lastname: El Ansari
authors.affiliation: Institute of Urology & Andrology, Norderstedt-Hamburg, Germany.
authors.forename: D-J
authors.initials: DJ
authors.lastname: Yassin
authors.affiliation: Institute of Urology & Andrology, Norderstedt-Hamburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Salman
authors.affiliation: Department of Urology & Andrology, Hamad General Hospital, Doha, Qatar.|Department of Surgery, Hamad General Hospital, Doha, Qatar.
authors.forename: A
authors.initials: A
authors.lastname: Al-Ansari
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D009765:Obesity / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D011467:Prostate / Q000187:drug effects*; D013739:Testosterone / Q000627:therapeutic use*; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008055:Lipids; D013739:Testosterone
keywords: erectile dysfunction; hypogonadism; metabolic syndrome; quality of life; testosterone therapy