title: Effect of volume of porogens on the porosity of PLGA scaffolds in pH-controlled environment.
abstract: Poly(lactic-co-glycolic acid) (PLGA) is a well-studied biodegradable polymer used in drug delivery and other medical applications such as in tissue regeneration. It is often necessary to impart porosity within the scaffold (microparticles) in order to promote the growth of tissue during the regeneration process. Sodium chloride and ammonium bicarbonate have been extensively used as porogens in the generation of porous microstructure. In this study, we compared the effect of volumes (250 μl, 500 μl and 750 μl) of two porogens, sodium chloride (1.71 M) and ammonium bicarbonate (1.71 M), on the porosity of PLGA microparticles.
authors.affiliation: a Drug Delivery Laboratory, School of Pharmacy , University of Nottingham Malaysia Campus , Semenyih , Malaysia.|b School of Pharmacy , Monash University Malaysia , Bandar Sunway , Malaysia.
authors.forename: Manish
authors.initials: M
authors.lastname: Gupta
authors.affiliation: a Drug Delivery Laboratory, School of Pharmacy , University of Nottingham Malaysia Campus , Semenyih , Malaysia.|c Pharmaceutical Manufacturing Technology Centre, University of Limerick , Limerick , Ireland.
authors.forename: Adeyinka
authors.initials: A
authors.lastname: Aina
authors.affiliation: a Drug Delivery Laboratory, School of Pharmacy , University of Nottingham Malaysia Campus , Semenyih , Malaysia.
authors.forename: Yamina
authors.initials: Y
authors.lastname: Boukari
authors.affiliation: a Drug Delivery Laboratory, School of Pharmacy , University of Nottingham Malaysia Campus , Semenyih , Malaysia.|d Penang Medical College , George Town , Malaysia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Doughty
authors.affiliation: a Drug Delivery Laboratory, School of Pharmacy , University of Nottingham Malaysia Campus , Semenyih , Malaysia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Morris
authors.affiliation: a Drug Delivery Laboratory, School of Pharmacy , University of Nottingham Malaysia Campus , Semenyih , Malaysia.
authors.forename: Nashiru
authors.initials: N
authors.lastname: Billa
mesh_terms: D001639:Bicarbonates / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity / Q000187:drug effects*; D012965:Sodium Chloride / Q000737:chemistry
chemical_list: D001639:Bicarbonates; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012965:Sodium Chloride; C027043:ammonium bicarbonate
keywords: PLGA; Porosity; scaffolds; tissue regeneration and porogens