title: CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice.
abstract: Despite the existence of various databases cataloging cancer drugs, there is an emerging need to support the development and application of personalized therapies, where an integrated understanding of the clinical factors and drug mechanism of action and its gene targets is necessary. We have developed CATTLE (CAncer Treatment Treasury with Linked Evidence), a comprehensive cancer drug knowledge base providing information across the complete spectrum of the drug life cycle. The CATTLE system collects relevant data from 22 heterogeneous databases, integrates them into a unified model centralized on drugs, and presents comprehensive drug information via an interactive web portal with a download function. A total of 2,323 unique cancer drugs are currently linked to rich information from these databases in CATTLE. Through two use cases, we demonstrate that CATTLE can be used in supporting both research and practice in personalized oncology.
authors.affiliation: University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: E
authors.initials: E
authors.lastname: Soysal
authors.affiliation: University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: L-C
authors.initials: LC
authors.lastname: Huang
authors.affiliation: University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.affiliation: University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Wei
authors.affiliation: University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: W
authors.initials: W
authors.lastname: Zheng
authors.affiliation: University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Chang
authors.affiliation: University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: T
authors.initials: T
authors.lastname: Cohen
authors.affiliation: University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: J
authors.initials: J
authors.lastname: Sun
authors.affiliation: University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: H
authors.initials: H
authors.lastname: Xu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D035843:Biomedical Research / Q000706:statistics & numerical data* / Q000639:trends; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D016208:Databases, Factual / Q000706:statistics & numerical data / Q000639:trends; D055808:Drug Discovery / Q000706:statistics & numerical data* / Q000639:trends; D006801:Humans; D051188:Knowledge Bases; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D057285:Precision Medicine / Q000706:statistics & numerical data* / Q000639:trends
chemical_list: D000970:Antineoplastic Agents