title: How to control cyclic nucleotide signaling by light.
abstract: Optogenetics allows to non-invasively manipulate cellular functions with spatio-temporal precision by combining genetic engineering with the control of protein function by light. Since the discovery of channelrhodopsin has pioneered the field, the optogenetic toolkit has been ever expanding and allows now not only to control neuronal activity by light, but rather a multitude of other cellular functions. One important application that has been established in recent years is the light-dependent control of second messenger signaling. The optogenetic toolkit now allows to control cyclic nucleotide-dependent signaling by light in vitro and in vivo.
authors.affiliation: Center of Advanced European Studies and Research (caesar), Minerva Max Planck Research Group, Molecular Physiology, Bonn, Germany.
authors.forename: Vera
authors.initials: V
authors.lastname: Jansen
authors.affiliation: Center of Advanced European Studies and Research (caesar), Minerva Max Planck Research Group, Molecular Physiology, Bonn, Germany.
authors.forename: Jan F
authors.initials: JF
authors.lastname: Jikeli
authors.affiliation: Center of Advanced European Studies and Research (caesar), Minerva Max Planck Research Group, Molecular Physiology, Bonn, Germany; Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany. Electronic address: dagmar.wachten@caesar.de.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Wachten
mesh_terms: D000818:Animals; D006801:Humans; D008027:Light; D009474:Neurons / Q000378:metabolism / Q000528:radiation effects; D009711:Nucleotides / Q000378:metabolism; D009712:Nucleotides, Cyclic / Q000378:metabolism* / Q000528:radiation effects*; D062308:Optogenetics / Q000379:methods*; D015398:Signal Transduction / Q000528:radiation effects
chemical_list: D009711:Nucleotides; D009712:Nucleotides, Cyclic