title: K2CO3-Mediated Cyclization and Rearrangement of γ,δ-Alkynyl Oximes To Form Pyridols.
abstract: A novel K2CO3-mediated cyclization and rearrangement of γ,δ-alkynyl oximes for the synthesis of pyridols is described. The process accomplishes an efficient [1,3] rearrangement of the O-vinyl oxime intermediate which is in situ generated from the intramolecular nucleophilic addition of γ,δ-alkynyl oximes. The reaction employs readily accessible starting materials, tolerates a wide range of functional groups, and gives a variety of synthetically challenging pyridols in good yields.
authors.affiliation: Key Laboratory of Synthetic and Nature Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University , Xi'an 710127, P. R. China.
authors.forename: Shun
authors.initials: S
authors.lastname: Wang
authors.affiliation: Key Laboratory of Synthetic and Nature Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University , Xi'an 710127, P. R. China.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Guo
authors.affiliation: Key Laboratory of Synthetic and Nature Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University , Xi'an 710127, P. R. China.
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Ren
authors.affiliation: Key Laboratory of Synthetic and Nature Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University , Xi'an 710127, P. R. China.
authors.forename: Yao-Yu
authors.identifier: 0000-0002-0800-7093
authors.initials: YY
authors.lastname: Wang
authors.affiliation: Key Laboratory of Synthetic and Nature Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University , Xi'an 710127, P. R. China.
authors.forename: Zheng-Hui
authors.identifier: 0000-0003-4901-5951
authors.initials: ZH
authors.lastname: Guan