title: [Intracardiac Thrombosis in a Child With Hereditary Thrombophilia].
abstract: A child who had undergone subclavian vein catheterization in the neonatal period was hospitalized in a grave condition at the age of 1 year 7 months with echocardiographic signs of right ventricular thrombus. Further examination revealed low level of protein C and mutations in methylenetetrahydrofolate reductase and plasminogen activator inhibitor-1 genes. Basing on this observation, the authors recommend purposeful search for genetic thrombophilia in children with history of prolonged catheterization of veins and prophylactic anticoagulation therapy in case of positive result. article describes a case of intracardiac thrombosis in a child 1 year 7 month having a reduction of protein C and mutations in the genes of methylenetetrahydrofolate reductase and plasminogen activator inhibitor 1. e suffered a subclavian vein catheterization in the neonatal period. The patient was hospitalized in serious condition. According to the results of echocardiography revealed a thrombus in the right ventricle. This case shows that the intracardiac thrombi in children are the result of exposure to many of prothrombotic factors. With this in mind, the authors recommend a survey of genetic thrombophilia children having long vein catheterization and use of anticoagulation therapy as a prophylactic measure.
authors.affiliation: 1Buryat State University, Ulan-Ude, Russia; 2Buryat branch of the Scientific Center of family health problems and human reproduction, Ulan-Ude, Russia; 3Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Zhdanova
authors.affiliation: 1Buryat State University, Ulan-Ude, Russia; 2Buryat branch of the Scientific Center of family health problems and human reproduction, Ulan-Ude, Russia; 3Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Bimbaev
authors.affiliation: 1Buryat State University, Ulan-Ude, Russia; 2Buryat branch of the Scientific Center of family health problems and human reproduction, Ulan-Ude, Russia; 3Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.
authors.forename: R B
authors.initials: RB
authors.lastname: Gatipova
authors.affiliation: 1Buryat State University, Ulan-Ude, Russia; 2Buryat branch of the Scientific Center of family health problems and human reproduction, Ulan-Ude, Russia; 3Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Patrushev
mesh_terms: D004452:Echocardiography; D005260:Female; D006331:Heart Diseases / Q000209:etiology* / Q000473:pathology; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D007223:Infant; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009154:Mutation; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D015912:Thrombolytic Therapy; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics; D013927:Thrombosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
chemical_list: D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)