title: Improved shear wave motion detection using coded excitation for transient elastography.
abstract: Transient elastography (TE) is well adapted for use in studying liver elasticity. However, because the shear wave motion signal is extracted from the ultrasound signal, the weak ultrasound signal can significantly deteriorate the shear wave motion tracking process and make it challenging to detect the shear wave motion in a severe noise environment, such as within deep tissues and within obese patients. This paper, therefore, investigated the feasibility of implementing coded excitation in TE for shear wave detection, with the hypothesis that coded ultrasound signals can provide robustness to weak ultrasound signals compared with traditional short pulse. The Barker 7, Barker 13, and short pulse were used for detecting the shear wave in the TE application. Two phantom experiments and one in vitro liver experiment were done to explore the performances of the coded excitation in TE measurement. The results show that both coded pulses outperform the short pulse by providing superior shear wave signal-to-noise ratios (SNR), robust shear wave speed measurement, and higher penetration intensity. In conclusion, this study proved the feasibility of applying coded excitation in shear wave detection for TE application. The proposed method has the potential to facilitate robust shear elasticity measurements of tissue.
authors.affiliation: School of Biomedical Engineering, Shenzhen University, Shenzhen, China.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China.
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: He
authors.affiliation: School of Biomedical Engineering, Shenzhen University, Shenzhen, China.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China.
authors.forename: Xian-Fen
authors.initials: XF
authors.lastname: Diao
authors.affiliation: School of Biomedical Engineering, Shenzhen University, Shenzhen, China.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China.
authors.forename: Hao-Ming
authors.initials: HM
authors.lastname: Lin
authors.affiliation: School of Biomedical Engineering, Shenzhen University, Shenzhen, China.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China.
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: School of Biomedical Engineering, Shenzhen University, Shenzhen, China.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Shen
authors.affiliation: School of Biomedical Engineering, Shenzhen University, Shenzhen, China.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China.
authors.forename: Si-Ping
authors.initials: SP
authors.lastname: Chen
authors.affiliation: School of Biomedical Engineering, Shenzhen University, Shenzhen, China.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China.
authors.forename: Zheng-Di
authors.initials: ZD
authors.lastname: Qin
authors.affiliation: School of Biomedical Engineering, Shenzhen University, Shenzhen, China.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D004548:Elasticity / Q000502:physiology*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D055590:Electromagnetic Phenomena; D006801:Humans; D008099:Liver / Q000502:physiology / Q000648:ultrastructure*; D033081:Shear Strength / Q000502:physiology*; D059629:Signal-To-Noise Ratio; D013552:Swine / Q000502:physiology; D014463:Ultrasonography