title: Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients.
abstract: BACKGROUND
  FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infections. We studied the association of Foxp3 polymorphisms in severe RRP patients.
  
  
  METHODS
  A total of 30 Korean severe RRP patients and 195 healthy controls were enrolled. Foxp3 polymorphisms (rs5902434 del/ATT, rs3761548 C/A, rs3761549 C/T, and rs2232365 G/A) were determined by PCR and sequencing.
  
  
  RESULTS
  Genotype frequencies (GF) of rs5902434 ATT/ATT and rs2232365 GG were significantly decreased in female RRP patients than controls (0.0% vs 23.0%, p = 0.039, OR = 9.4 for both).
  
  
  CONCLUSIONS
  We showed that Foxp3 polymorphism of rs5902434 and rs2232365 could be an important protective factor in the susceptibility of severe RRP in female Koreans. Further studies on larger number of patients and other ethnic groups are needed to clarify the association.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Tack-Kyun
authors.initials: TK
authors.lastname: Kwon
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Eun Jae
authors.initials: EJ
authors.lastname: Chung
authors.affiliation: Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
authors.forename: Nuri
authors.initials: N
authors.lastname: Lee
authors.affiliation: Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
authors.forename: Eun Youn
authors.initials: EY
authors.lastname: Roh
authors.affiliation: Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea. eysong1@snu.ac.kr.
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D056910:Republic of Korea; D012141:Respiratory Tract Infections / Q000235:genetics*; D055815:Young Adult
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors
keywords: Disease susceptibility; Foxp3; Human papilloma virus; Recurrent respiratory papillomatosis; Single nucleotide polymorphism