title: Construction of Fused Polyheterocycles through Sequential [4 + 2] and [3 + 2] Cycloadditions.
abstract: A method for Pd-catalyzed aerobic oxidative reaction of quinazolinones and alkynes has been developed for sequential [4 + 2] and [3 + 2] cycloadditions to assemble a novel fused-polycyclic system containing tetrahydropyridine and dihydrofuran rings. The reaction process involves C-H and N-H bond functionalization for the formation of tetrahydropyridine and an oxygen radical cyclization for the dihydrofuran ring. This atom- and step-economical synthesis is highly efficient and has good substrate tolerance, which provides a new approach for the construction of polycyclic molecules with potential pharmaceutical interest.
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institute of Molecular Medicine and School of Biomedical Sciences, Huaqiao University , Xiamen 361021, China.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institute of Molecular Medicine and School of Biomedical Sciences, Huaqiao University , Xiamen 361021, China.
authors.forename: Nian
authors.initials: N
authors.lastname: Tian
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institute of Molecular Medicine and School of Biomedical Sciences, Huaqiao University , Xiamen 361021, China.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institute of Molecular Medicine and School of Biomedical Sciences, Huaqiao University , Xiamen 361021, China.
authors.forename: Chunqi
authors.initials: C
authors.lastname: Jia
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institute of Molecular Medicine and School of Biomedical Sciences, Huaqiao University , Xiamen 361021, China.
authors.forename: Xuening
authors.initials: X
authors.lastname: Li
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institute of Molecular Medicine and School of Biomedical Sciences, Huaqiao University , Xiamen 361021, China.
authors.forename: Lianhui
authors.initials: L
authors.lastname: Wang
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institute of Molecular Medicine and School of Biomedical Sciences, Huaqiao University , Xiamen 361021, China.
authors.forename: Xiuling
authors.identifier: 0000-0001-5759-766X
authors.initials: X
authors.lastname: Cui