title: A biophysical model of how α-tubulin carboxy-terminal tails tune kinesin-1 processivity along microtubule.
abstract: It appears that so-called post-translational modifications of tubulin heterodimers are mostly focussed at positions of amino acid sequences of carboxy-terminal tails. These changes have very profound effects on microtubule functions especially in connection with cellular traffic in terms of motor proteins. In this study, we elaborated the biophysical model aimed to explain the strategy governing these subtle interplays between structural and functional properties of microtubules. We relied onto Langevin equations including fluctuation-dissipation processes. In that context we found out that small interaction between a charged motor neck domain and oppositely charged carboxy-terminal tail of the α-tubulin plays the decisive role in tuning kinesin-1 motor processivity along microtubules.
authors.affiliation: University of Novi Sad, Faculty of Technical Sciences, Novi Sad, Serbia.
authors.forename: Miljko V
authors.initials: MV
authors.lastname: Sataric
authors.affiliation: University of Novi Sad, Faculty of Technical Sciences, Novi Sad, Serbia. Electronic address: dalsek@uns.ac.rs.
authors.forename: Dalibor L
authors.initials: DL
authors.lastname: Sekulic
authors.affiliation: University of Belgrade, Institute of Nuclear Sciences Vinca, Belgrade, Serbia.
authors.forename: Slobodan
authors.initials: S
authors.lastname: Zdravkovic
authors.affiliation: University of Novi Sad, Faculty of Technical Sciences, Novi Sad, Serbia.
authors.forename: Nebojsa M
authors.initials: NM
authors.lastname: Ralevic
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001703:Biophysics / Q000379:methods*; D003599:Cytoskeleton; D006801:Humans; D016547:Kinesins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D020409:Molecular Motor Proteins; D011499:Protein Processing, Post-Translational; D014404:Tubulin / Q000378:metabolism* / Q000502:physiology
chemical_list: D020409:Molecular Motor Proteins; D014404:Tubulin; D016547:Kinesins
keywords: Carboxy–terminal tails; Cytoskeleton; Kinesin–1; Microtubule; Motor proteins; Post–translational modifications