title: Chemical composition, antioxidant activity and cytotoxicity on tumour cells of the essential oil from flowers of Magnolia grandiflora cultivated in Iran.
abstract: Magnolia grandiflora (Magnoliaceae) is an evergreen tree with fragrant and showy flowers native to southeastern USA but widely cultivated all over the world and used in cosmetics industry in treatment of skin diseases. Here, we report on the chemical analysis of the essential oil obtained from flowers of plants cultivated in Iran, together with the evaluation of its antioxidant and cytotoxic activities. The essential oil composition was dominated by bioactive sesquiterpenes, namely β-elemene, bicyclogermacrene, germacrene D and (E)-caryophyllene. The oil exhibited moderate radical scavenging activity towards the [Formula: see text] radical, and mild non-selective inhibitory effects against A375, MDA-MB 231 and T98 G tumour cell lines. The latter were influenced by the presence of the anticancer β-elemene. These results provided new insights for potential application of M. grandiflora volatile oil in the pharmaceutical and cosmetics industry where only the non-volatile magnolol and honokiol have hitherto been fully exploited.
authors.affiliation: a Faculty of Agriculture, Department of Horticulture , University of Maragheh , Maragheh , Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Morshedloo
authors.affiliation: b School of Pharmacy , University of Camerino , Camerino , Italy.
authors.forename: Luana
authors.initials: L
authors.lastname: Quassinti
authors.affiliation: b School of Pharmacy , University of Camerino , Camerino , Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Bramucci
authors.affiliation: b School of Pharmacy , University of Camerino , Camerino , Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Lupidi
authors.affiliation: b School of Pharmacy , University of Camerino , Camerino , Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Maggi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D035264:Flowers / Q000737:chemistry; D006801:Humans; D007492:Iran; D031566:Magnolia / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D009822:Oils, Volatile; D010936:Plant Extracts; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; C445979:beta-elemene; C024714:caryophyllene; C027259:germacrene D
keywords: GC-MS; Magnolia grandiflora; antioxidant; cytotoxicity; essential oil; β-elemene