title: Consistency Test between Scoring Systems for Predicting Outcomes of Chronic Myeloid Leukemia in a Saudi Population Treated with Imatinib.
abstract: Inconsistency in prognostic scores occurs where two different risk categories are applied to the same chronic myeloid leukemia (CML) patient. This study evaluated common scoring systems for identifying risk groups based on patients' molecular responses to select the best prognostic score when conflict prognoses are obtained from patient profiles. We analyzed 104 patients diagnosed with CML and treated at King Abdulaziz Medical City, Saudi Arabia, who were monitored for major molecular response (achieving aBCR-ABL1transcript level equal to or less than 0.1%) by Real-Time Quantitative Polymerase Chain Reaction (RQ-PCR), and their risk profiles were identified using Sokal, Hasford, EUTOS, and ELTS scores based on the patients' clinical and hematological parameters at diagnosis. Our results found that the Hasford score outperformed other scores in identifying risk categories for conflict groups, with an accuracy of 63%.
authors.affiliation: The Department of Computer Science, King Abdulaziz University, Jeddah, Saudi Arabia; School of Computer Science, University of Adelaide, Adelaide, SA, Australia.
authors.forename: Haneen R
authors.identifier: 0000-0003-4475-4878
authors.initials: HR
authors.lastname: Banjar
authors.affiliation: Pathology and Laboratory Medicine, King Abdulaziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia.
authors.forename: Enaam
authors.identifier: 0000-0002-5592-2921
authors.initials: E
authors.lastname: Alsobhi