title: Association between ACTN3 R577X Polymorphism and Trunk Flexibility in 2 Different Cohorts.
abstract: α-Actinin-3 (ACTN3) R577X polymorphism is associated with muscular strength and power. This study was performed to investigate the association between ACTN3 R577X polymorphisms and flexibility as another component of fitness in 2 cohorts. Cohort 1 consisted of 208 men and 568 women (ages 23-88), while Cohort 2 consisted of 529 men and 728 women (ages 23-87). All participants were recruited from the Tokyo metropolitan area and underwent a battery of tests to assess their grip strength and sit-and-reach flexibility. Genotyping results were analyzed for ACTN3 (rs1815739) polymorphism using the TaqMan approach. In Cohort 1, sit-and-reach in the RR genotype (35.3±0.7 cm) was significantly lower than those in the RX and XX genotypes (37.2±0.3 cm) even after adjusting for sex, age, and exercise habit as covariates (P<0.01). In Cohort 2, sit-and-reach tended to be lower in RR (38.1±0.6 cm) than in RX and XX (39.1±0.3 cm), but the differences were not significant (P=0.114). Analysis in pooled subjects indicated that RR was associated with significantly lower flexibility than RX and XX (P=0.009). The RR genotype of ACTN3 R577X in the general Japanese population showed lower flexibility compared to the RX and XX genotypes.
authors.affiliation: Department of Training Science, Nippon Sport Science University, Tokyo, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Kikuchi
authors.affiliation: Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Zempo
authors.affiliation: Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Fuku
authors.affiliation: Health Promotion and Exercise Program, National Institute of Health and Nutrition, NIBIOHN, Tokyo, Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Murakami
authors.affiliation: Department of Exercise Physiology, Nippon Sport Science University, Tokyo, Japan.
authors.forename: Mikako
authors.initials: M
authors.lastname: Sakamaki-Sunaga
authors.affiliation: Department of Exercise Physiology, Nippon Sport Science University, Tokyo, Japan.
authors.forename: Takanobu
authors.initials: T
authors.lastname: Okamoto
authors.affiliation: Department of Exercise Physiology, Nippon Sport Science University, Tokyo, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Nakazato
authors.affiliation: Health Promotion and Exercise Program, National Institute of Health and Nutrition, NIBIOHN, Tokyo, Japan.
authors.forename: Motohiko
authors.initials: M
authors.lastname: Miyachi
mesh_terms: D000185:Actinin / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology*; D011110:Polymorphism, Genetic; D016059:Range of Motion, Articular / Q000502:physiology; D060726:Torso / Q000502:physiology*; D055815:Young Adult
chemical_list: C118456:ACTN3 protein, human; D000185:Actinin