title: Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host.
abstract: Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies aimed at the development of novel and more specific drugs to treat chagasic patients. The primary tool for facing this challenge is deep knowledge about the similarities and differences between the parasite and its human host.
authors.affiliation: Vitor Sueth-Santiago, Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro, Campus São Gonçalo, Rua José Augusto Pereira dos Santos, São Gonçalo, CEP 24425-004, Brazil.
authors.forename: Vitor
authors.initials: V
authors.lastname: Sueth-Santiago
authors.affiliation: Vitor Sueth-Santiago, Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro, Campus São Gonçalo, Rua José Augusto Pereira dos Santos, São Gonçalo, CEP 24425-004, Brazil.
authors.forename: Debora
authors.initials: D
authors.lastname: Decote-Ricardo
authors.affiliation: Vitor Sueth-Santiago, Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro, Campus São Gonçalo, Rua José Augusto Pereira dos Santos, São Gonçalo, CEP 24425-004, Brazil.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Morrot
authors.affiliation: Vitor Sueth-Santiago, Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro, Campus São Gonçalo, Rua José Augusto Pereira dos Santos, São Gonçalo, CEP 24425-004, Brazil.
authors.forename: Celio Geraldo
authors.initials: CG
authors.lastname: Freire-de-Lima
authors.affiliation: Vitor Sueth-Santiago, Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro, Campus São Gonçalo, Rua José Augusto Pereira dos Santos, São Gonçalo, CEP 24425-004, Brazil.
authors.forename: Marco Edilson Freire
authors.initials: ME
authors.lastname: Lima
keywords: CYP51; Cruzipain; Trans-sialidase; Trypanosoma cruzi; Trypanothione reductase; Tubulin