title: Chondroradionecrosis of the larynx: 24-year University of Wisconsin experience.
abstract: Chondroradionecrosis (CRN) is an uncommon but significant complication of laryngeal radiotherapy that presents a diagnostic challenge to clinicians through its similarity in presentation to cancer recurrence.
  
  
  
  Two hundred ninety-four patients underwent primary, adjuvant, or salvage radiation for laryngeal cancer from 1991 to 2015 at the University of Wisconsin. Medical records were reviewed to identify and characterize patients with a diagnosis of CRN.
  
  
  
  Of the 294 patients, 7 cases (2.4%) of CRN were identified. Development of CRN was associated with the presence of cartilage invasion by tumor (p = .038) and ongoing alcohol use postradiotherapy (p = .036). Additionally, a trend between development of CRN and ongoing smoking postradiotherapy was observed (p = .067).
  
  
  
  The diagnosis of CRN is challenging, and the likelihood of successful resolution is modest. A high premium should be placed on efforts directed at prevention, such as tobacco and alcohol cessation. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1189-1194, 2017.
authors.affiliation: Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Gessert
authors.affiliation: Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Britt
authors.affiliation: Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
authors.forename: Austin M W
authors.initials: AMW
authors.lastname: Maas
authors.affiliation: Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Wieland
authors.affiliation: Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Harari
authors.affiliation: Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
authors.forename: Gregory K
authors.initials: GK
authors.lastname: Hartig
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D007825:Laryngectomy / Q000379:methods; D007830:Larynx / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D011379:Prognosis; D011832:Radiation Injuries / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects / Q000379:methods; D035583:Rare Diseases; D012189:Retrospective Studies; D018570:Risk Assessment; D016879:Salvage Therapy / Q000379:methods*; D012720:Severity of Illness Index; D016019:Survival Analysis; D014922:Wisconsin
keywords: chondroradionecrosis; larynx; radiation; radiation injury; radionecrosis