title: Antimicrobial susceptibility ofLeptospiraspp. isolated from environmental, human and animal sources in Malaysia.
abstract: Leptospirosis is a zoonosis with worldwide distribution caused by pathogenic spirochetes of the genus Leptospira. The aim of this study was to evaluate the susceptibility of isolates obtained from different hosts. A total of 65 Leptospira isolates from humans (n = 1), zoonoses (rat, n = 60; dog, n = 1; swine, n = 1) and environment (n = 2) were tested against six antibiotics. All the isolates were resistant to trimethoprim and sulphamethoxazole and had high MIC toward chloramphenicol (MIC90: 6.25 μg/ml). All except one environment isolate were sensitive to ampicillin, doxycycline and penicillin G.
authors.affiliation: Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Douadi
authors.initials: D
authors.lastname: Benacer
authors.affiliation: Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Siti Nursheena Mohd
authors.initials: SN
authors.lastname: Zain
authors.affiliation: Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Malaysia.
authors.forename: Peck Toung
authors.initials: PT
authors.lastname: Ooi
authors.affiliation: Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Kwai Lin
authors.initials: KL
authors.lastname: Thong
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004285:Dogs; D004783:Environmental Microbiology; D006801:Humans; D007919:Leptospira / Q000187:drug effects* / Q000302:isolation & purification*; D007922:Leptospirosis / Q000382:microbiology* / Q000662:veterinary*; D008296:Malaysia; D008826:Microbial Sensitivity Tests; D051381:Rats; D013552:Swine
chemical_list: D000900:Anti-Bacterial Agents