title: Prokaryotic Argonaute Uses an All-in-One Mechanism to Provide Host Defense.
abstract: In this issue, Swarts et al. (2017) discover that prokaryotic Argonaute proteins generate their own DNA guide strands through a newly characterized, unguided "chopping" activity. Double-stranded chopping products are selectively loaded onto Argonaute, enabling DNA-guided defense against foreign DNA.
authors.affiliation: Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50011, USA. Electronic address: sashital@iastate.edu.
authors.forename: Dipali G
authors.initials: DG
authors.lastname: Sashital
mesh_terms: D060565:Argonaute Proteins / Q000235:genetics*; D004247:DNA; D011387:Prokaryotic Cells
chemical_list: D060565:Argonaute Proteins; D004247:DNA