title: Palladium-Catalyzed Cross-Coupling of N-Sulfonylaziridines and Alkenylboronic Acids: Stereospecific Synthesis of Homoallylic Amines with Di- and Trisubstituted Alkenes.
abstract: A palladium-catalyzed cross-coupling of 2-alkylaziridines with alkenylboronic acids to give homoallylamines is presented. The reaction is highly regioselective and stereospecific and provides convenient access to enantioenriched amines with 1,1-disubstituted, 1,2-disubstituted, and trisubstituted alkenes. The modular synthesis of a 2,5-disubstituted pyrrolidine natural product was completed in three steps and 67% overall yield.
authors.affiliation: Department of Chemistry, University of Washington , Box 351700, Seattle, Washington 98105, United States.
authors.forename: Wei Pin
authors.identifier: 0000-0003-1090-7477
authors.initials: WP
authors.lastname: Teh
authors.affiliation: Department of Chemistry, University of Washington , Box 351700, Seattle, Washington 98105, United States.
authors.forename: Forrest E
authors.identifier: 0000-0001-8071-4676
authors.initials: FE
authors.lastname: Michael