title: Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder.
abstract: Obsessive-compulsive disorder (OCD) is a complex and severe psychiatric disorder whose pathogenesis is not fully understood. Recent studies have shown white matter (WM) alterations in adults with OCD, but the results have been inconsistent. The present study investigated WM structure in OCD patients with the hypothesis that large-scale brain networks may be disrupted in OCD. A total of 24 patients with OCD and 23 healthy controls (HCs) were scanned with diffusion tensor imaging. A tract-based spatial statistics (TBSS) approach was used to detect differences across the whole brain in patients with OCD vs HCs; post hoc fiber tractography was applied to characterize developmental differences between the two groups. Relative to HCs, patients with OCD had lower fractional anisotropy (FA) values in the corpus callosum (CC), left anterior corona radiata (ACR), left superior corona radiata (SCR) and left superior longitudinal fasciculus (SLF), and higher radial diffusivity in the genu and body of CC. Among the TBSS de-projected region of interest results, compared with HCs, patients with OCD showed lower of the mean FA values of fiber bundles passing though the SLF, and shorter lengths of ACR, SCR and CC. In conclusion, this study provides novel evidence of widespread microstructural alterations in OCD and suggests that OCD may involve abnormalities affecting a broader network of regions than commonly believed.
authors.affiliation: Medical Psychological Center, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|Medical Psychological Institute of Central South University, Changsha, Hunan, China.
authors.forename: J
authors.initials: J
authors.lastname: Gan
authors.affiliation: Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China.
authors.forename: M
authors.initials: M
authors.lastname: Zhong
authors.affiliation: Medical Psychological Center, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|Medical Psychological Institute of Central South University, Changsha, Hunan, China.
authors.forename: J
authors.initials: J
authors.lastname: Fan
authors.affiliation: Medical Psychological Center, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|Medical Psychological Institute of Central South University, Changsha, Hunan, China.
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.affiliation: Medical Psychological Center, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|Medical Psychological Institute of Central South University, Changsha, Hunan, China.
authors.forename: C
authors.initials: C
authors.lastname: Niu
authors.affiliation: Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: S
authors.initials: S
authors.lastname: Cai
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: L
authors.initials: L
authors.lastname: Zou
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: C
authors.initials: C
authors.lastname: Tan
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: R C K
authors.initials: RC
authors.lastname: Chan
authors.affiliation: Medical Psychological Center, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|Medical Psychological Institute of Central South University, Changsha, Hunan, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology; D066127:White Matter / Q000000981:diagnostic imaging* / Q000503:physiopathology; D055815:Young Adult