title: Hypothesis: ROBOPHERA, a phosphatase and tensin homolog-targeted antineoplastic therapy.
abstract: Phosphatase and tensin homolog (PTEN) is a protein that regulates cellular response to growth/antigrowth signals, cell survival, apoptosis, proliferation, angiogenesis, and cellular migration. Impairments in these processes are the main hallmarks of cancer, and reduced expression, activity, or stability of PTEN are among the most common etiologies of diverse types of sporadic cancers. Rosiglitazone (RO), bortezomib (BO), phosphatidylserine (PH), ethanol (E), and radiotherapy (RA) (ROBOPHERA) stimulate the expression and increase the activity of PTEN. Here, it is hypothesized that the synergistic effects of these medications on cancerous cells may stimulate differentiation of cancer stem cells toward non-stem-cancer cells, hinder progression and metastasis of the cancer, sensitize cancerous cells to antineoplastic therapies, and increase the efficacy and the rate of success of current treatments.
authors.affiliation: Shiraz School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Arsalan
authors.initials: A
authors.lastname: Azimi
authors.forename: Arian
authors.initials: A
authors.lastname: Azimi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000069286:Bortezomib / Q000008:administration & dosage; D002454:Cell Differentiation / Q000187:drug effects / Q000528:radiation effects; D059248:Chemoradiotherapy; D004357:Drug Synergism; D000431:Ethanol / Q000008:administration & dosage; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology / Q000532:radiotherapy*; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000528:radiation effects; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D010718:Phosphatidylserines / Q000008:administration & dosage; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage
chemical_list: D010718:Phosphatidylserines; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D000431:Ethanol; D000069286:Bortezomib; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human