title: Burn-Related Dysregulation of Inflammation and Immunity in Experimental and Clinical Studies.
abstract: The purpose of this study was to evaluate burn-related variations of inflammation and immunity. Fifty-five mice were divided randomly into sham burn and burn groups. Eighty-seven hospitalized burn patients were also reviewed. In mice, neutrophils and monocytes were elevated significantly on post burn day (PBD 1). Lymphocytes were reduced on PBDs 1 and 3. Levels of serum tumor necrosis factor-α and interleukin-6 were highest on PBD 1. Interleukin-1β levels were the highest on PBD 3. On PBD 3, CD4CD25T regulatory cells/CD4 cells in spleen were higher. On PBDs 1, 3, 7, and 14, percentage of splenic dendritic cells were significantly lower than the sham burn group. In patients, neutrophils and monocytes were significantly elevated on PBD 1. Levels declined but remained elevated at most days to PBD 7. Lymphocytes in burn groups 1 and 2 were reduced on PBDs 1 and 3, respectively. Our results exhibited that severe burn injury initiated a hyperinflammatory response and immunosuppression. PBDs 1 to 3 were important for changes in inflammation and immunosuppression.
authors.affiliation: *Department of Burn Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China; †The Clinic of No.73901 Troop of PLA, Shanghai, China; and ‡Department of General Surgery, 309th Hospital of PLA, Beijing, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Xiao-Chen
authors.initials: XC
authors.lastname: Qiu
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Wang
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Hong
authors.forename: Guang-Yi
authors.initials: GY
authors.lastname: Wang
authors.forename: Zhao-Fan
authors.initials: ZF
authors.lastname: Xia
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000097:blood / Q000276:immunology* / Q000473:pathology*; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D006760:Hospitalization; D006801:Humans; D007249:Inflammation / Q000209:etiology; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D016207:Cytokines