title: Changes in circulating peptide YY and ghrelin are associated with early smoking relapse.
abstract: Ghrelin and peptide YY (PYY) during ad libitum smoking have been associated with decreased reported craving (ghrelin) and increased positive affect (PYY), and higher baseline ghrelin levels predicted subsequent increased risk of smoking relapse. The current study assessed PYY and ghrelin during ad libitum smoking and again after the initial 48h of a smoking cessation attempt. The data compared smokers who abstained for 28days (n=37), smokers who relapsed (n=54), and nonsmokers (n=37). Plasma samples and subjective measures assessing craving and mood were collected at the beginning of each session. Results showed that relapsers experienced greater levels of distress (ps <0.01). While nonsmokers and abstainers showed no change in ghrelin across the initial 48h, relapsers declined (p <0.01). With PYY, relapsers increased (p <0.05) across the early abstinent phase. PYY and ghrelin may be useful predictors of relapse, specifically in reference to early withdrawal.
authors.affiliation: Duluth Medical Research Institute, University of Minnesota Medical School, Duluth, MN, USA. Electronic address: lemie008@d.umn.edu.
authors.forename: Andrine M
authors.initials: AM
authors.lastname: Lemieux
authors.affiliation: Duluth Medical Research Institute, University of Minnesota Medical School, Duluth, MN, USA; Department of Biobehavioral Health and Population Sciences, University of Minnesota Medical School, Duluth, MN, USA. Electronic address: malabsi@umn.edu.
authors.forename: Mustafa
authors.initials: M
authors.lastname: al'Absi
mesh_terms: D000328:Adult; D066249:Craving / Q000502:physiology; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D008297:Male; D019894:Peptide YY / Q000097:blood*; D012008:Recurrence; D012907:Smoking / Q000097:blood* / Q000523:psychology; D016540:Smoking Cessation / Q000379:methods / Q000523:psychology*; D013315:Stress, Psychological / Q000097:blood* / Q000523:psychology
chemical_list: D054439:Ghrelin; D019894:Peptide YY
keywords: Craving; Ghrelin; Nicotine dependence; Peptide YY; Relapse; Withdrawal