title: [Cardiovascular Complications of Rheumatoid Arthritis: Prevalence and Pathogenesis].
abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with high risk of cardiovascular events. Among main causes of death in RA are: myocardial infarction, cerebrovascular accident, sudden cardiac death, which are determined by the early development and rapid progression of atherosclerotic vascular lesions. According to studies high risk of cardiovascular events is not explained by only classical risk factors. It is assumed that there are additional mechanisms of development of adverse outcomes such as systemic inflammation, increased arterial stiffness, and endothelial dysfunction. In this literature review we present various risk factors of cardiovascular events in patients with RA and their relation to RA pathogenesis.
authors.affiliation: Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Center, Moscow, Russia.|V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.
authors.forename: L B
authors.initials: LB
authors.lastname: Krougly
authors.affiliation: Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Center, Moscow, Russia.|V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Fomicheva
authors.affiliation: Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Center, Moscow, Russia.|V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Karpov
authors.affiliation: Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Center, Moscow, Russia.|V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Popkova
authors.affiliation: Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Center, Moscow, Russia.|V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.
authors.forename: D S
authors.initials: DS
authors.lastname: Novikova
authors.affiliation: Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Center, Moscow, Russia.|V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.
authors.forename: E L
authors.initials: EL
authors.lastname: Nasonov
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors
keywords: atherosclerosis; cardiology; cardiovascular complications; myocardial infarction; rheumatoid arthritis; rheumatology; stroke