title: Antioxidant and anti-osteoporotic effects of anthraquinones and related constituents from the aqueous dissolved Aloe exudates.
abstract: In this study, 25 known anthraquinones and related compounds were isolated from aqueous dissolved Aloe exudates. The antioxidant and anti-osteoporotic activities of the isolated compounds were then investigated. Compounds 8, 11, 20, and 23 showed good antioxidant activity based on peroxyl radical-scavenging and reducing capacity assays at a concentration of 10.0 μM. Additionally, compounds 7, 9, 15-16, 18, 21-22 and 24-25 showed potent peroxyl radical-scavenging activities with values ranging from 5.28 to 14.60 at 10.0 μM. Moreover, compounds 8, 11, 15, 20 and 22 exhibited significantly suppressed tartrate-resistant acid phosphatase (TRAP) activity in nuclear factor-κB ligand-activated osteoclastic RAW 264.7 cells, with values of 125.67, 118.54, 127.64, 125.82 and 124.98%, respectively. These results indicate that Aloe is an excellent source of antioxidant and anti-osteoporotic phytochemicals.
authors.affiliation: a College of Pharmacy , Chungnam National University , Daejeon , Korea.
authors.forename: Ya Nan
authors.initials: YN
authors.lastname: Sun
authors.affiliation: b Korean Medicine (KM) Application Center , Korea Institute of Oriental Medicine , Daegu , Korea.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: c Department of Food and Nutrition , Hannam University , Daejeon , Korea.
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Lee
authors.affiliation: c Department of Food and Nutrition , Hannam University , Daejeon , Korea.
authors.forename: Hae Dong
authors.initials: HD
authors.lastname: Jang
authors.affiliation: b Korean Medicine (KM) Application Center , Korea Institute of Oriental Medicine , Daegu , Korea.
authors.forename: Jin Yeul
authors.initials: JY
authors.lastname: Ma
authors.affiliation: a College of Pharmacy , Chungnam National University , Daejeon , Korea.
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D000880:Anthraquinones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D010010:Osteoclasts / Q000187:drug effects* / Q000378:metabolism; D010024:Osteoporosis / Q000188:drug therapy; D010545:Peroxides / Q000378:metabolism; D053147:Plant Exudates / Q000737:chemistry*; D000071681:Tartrate-Resistant Acid Phosphatase / Q000378:metabolism
chemical_list: D000880:Anthraquinones; D000975:Antioxidants; D016328:NF-kappa B; D010545:Peroxides; D053147:Plant Exudates; C049375:perhydroxyl radical; D000071681:Tartrate-Resistant Acid Phosphatase
keywords: Aloe; anthraquinone; anti-osteoporosis; antioxidant; asphodelaceae