title: A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test.
abstract: Lichenoid drug eruption (LDE) is a rare form of delayed-type drug eruption. Among anti-tuberculosis (Tb) agents, cycloserine (CS) has been reported as a rare cause of LDE. Positive results on the lymphocyte transformation test (LTT) have not been reported in patients with LDE. In the present case, we performed LTT and a patch test, and successfully proved CS as the offending drug in this patient, who had been treated with multiple anti-Tb drugs. These observations suggest that CS should be considered a possible cause of LDE and that LTT can be an option for the diagnosis of LDE.
authors.affiliation: Department of Pediatrics, Kangwon National University School of Medicine, Chuncheon, Korea.
authors.forename: Jakyoung
authors.initials: J
authors.lastname: Kim
authors.affiliation: The Research Department, Kangwon Regional Cancer Center, Kangwon National University Hospital, Chuncheon, Korea.
authors.forename: Shinyoung
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea.
authors.forename: Chul Min
authors.initials: CM
authors.lastname: Jung
authors.affiliation: Department of Dermatology, Kangwon National University School of Medicine, Chuncheon, Korea.
authors.forename: Chee Won
authors.initials: CW
authors.lastname: Oh
authors.affiliation: Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea.|Department of Allergy and Clinical Immunology, Kangwon National University School of Medicine, Chuncheon, Korea. legent@hanmail.net.
authors.forename: Jae Woo
authors.initials: JW
authors.lastname: Kwon
keywords: Cycloserine; drug eruptions; drug hypersensitivity; lichenoid eruptions; lymphocyte activation