title: Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy.
abstract: Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls. DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and of the therapeutic approaches.
authors.affiliation: Studio Oculistico d'Azeglio, Piazza Galileo, 6, 40123 Bologna, Italy. Electronic address: balduccinicole@gmail.com.
authors.forename: Nicole
authors.initials: N
authors.lastname: Balducci
authors.affiliation: Ophthalmology Unit, Policlinco Sant'Orsola-Malpighi, Via Palagi, 9, 40138 Bologna, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ciardella
authors.affiliation: GB Bietti Foundation IRCCS, Via Livenza, 3, 00128 Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gattegna
authors.affiliation: Optovue, Inc., 2800 Bayview Drive, Fremont, CA 94538, USA.
authors.forename: Qienyuan
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Scientific Institute San Raffaele, Via Olgettina, 60 Milan, Italy.
authors.forename: Maria Lucia
authors.initials: ML
authors.lastname: Cascavilla
authors.affiliation: Unit of Neurology, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Via Altura, 3, 40139 Bologna, Italy; IRCCS, Istituto delle Scienze Neurologiche di Bologna, Ospedale Bellaria, Via Altura, 3, 40139 Bologna, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: La Morgia
authors.affiliation: GB Bietti Foundation IRCCS, Via Livenza, 3, 00128 Rome, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Savini
authors.affiliation: GB Bietti Foundation IRCCS, Via Livenza, 3, 00128 Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Parisi
authors.affiliation: Scientific Institute San Raffaele, Via Olgettina, 60 Milan, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Bandello
authors.affiliation: Unit of Neurology, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Via Altura, 3, 40139 Bologna, Italy; IRCCS, Istituto delle Scienze Neurologiche di Bologna, Ospedale Bellaria, Via Altura, 3, 40139 Bologna, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Carelli
authors.affiliation: Studio Oculistico d'Azeglio, Piazza Galileo, 6, 40123 Bologna, Italy; Scientific Institute San Raffaele, Via Olgettina, 60 Milan, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Barboni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000792:Angiography / Q000379:methods*; D001284:Atrophy / Q000000981:diagnostic imaging* / Q000473:pathology; D001808:Blood Vessels / Q000000981:diagnostic imaging* / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D029241:Optic Atrophy, Autosomal Dominant / Q000000981:diagnostic imaging* / Q000473:pathology; D009898:Optic Disk / Q000000981:diagnostic imaging* / Q000473:pathology; D011446:Prospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult
keywords: DOA; Dominant optic atrophy; Inherited mitochondrial optic neuropathies; Optical coherence tomography angiography; Vessel density