title: Metabolism plays the key roles in Th cells differentiation.
abstract: The increasing rate of autoimmunity in recent decades cannot be related to only genetic instabilities and disorders. Diet can directly influence our health. Studies have shown that there is a relationship between nutritional elements and alteration in the immune system. Among immune cells, the function of T lymphocyte is important in directing immune response. T CD4+ cells lead other immune cells to respond to pathogens by secreting cytokines. HIV+ patients, who have largely lost their T CD4+ cells, are susceptible to opportunistic infections, which do not normally affect healthy people. It seems that the metabolism of T cells is critical for their differentiation and their consequent functions. After activation, T cells need to undergo clonal expansion, which is a high energy- consuming process. Studies have shown that specific metabolites deprivation or their excess supply affects T CD4+cells subsets differentiation. Abnormal induction of subsets of T CD4+ cells causes some autoimmunity reactions and hyper-sensitivity as well, which may result from imbalance of diet uptake. In this mini-review, we describe the findings about fatty acids, glucose, amino acids, and vitamins, which are effective in determining the fates of T CD4+ cells. These findings may help us uncover the role of diet in autoimmune diseases.
authors.affiliation: Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Safaieye, Yazd. aissouda@ssu.ac.ir.
authors.forename: A
authors.initials: A
authors.lastname: Hosseinzadeh
authors.forename: S
authors.initials: S
authors.lastname: Soukhtehzari
authors.forename: M
authors.initials: M
authors.lastname: Ghaedi
authors.forename: R
authors.initials: R
authors.lastname: Mansouri
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D002454:Cell Differentiation; D016207:Cytokines; D006801:Humans; D016176:T-Lymphocyte Subsets
chemical_list: D016207:Cytokines