title: Spoligotype defined lineages ofMycobacterium tuberculosisand drug resistance: Merely a casual correlation?
abstract: Drug-resistant tuberculosis (TB) is a major challenge to TB control strategy worldwide. Analysis of genetic polymorphism among drug resistant Mycobacterium tuberculosis (MTB) strains may help provide some insight into the transmission dynamics of these strains. Spoligotyping is a widely used technique to identify genetic polymorphism, based on 43 known spacers interspersed between direct repeat regions. Considerable work has been done in various parts of the world using this technique to identify and analyse the polymorphic nature of MTB. Many studies have been carried out to determine the association of drug resistance with spoligotype defined lineages, and much data has been produced over the years. New information continues to be generated. This review aims to put together the findings of relevant studies in an attempt to understand the correlation of drug resistance with spoligotype defined lineages of MTB. This would help provide a perspective of the available data that can be used as a starting point to understand the molecular epidemiology of drug resistant TB.
authors.affiliation: Department of Microbiology and NRL, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.
authors.forename: Nikita
authors.initials: N
authors.lastname: Panwalkar
authors.affiliation: National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Indian Council of Medical Research, Agra, Uttar Pradesh, India.
authors.forename: Devendra S
authors.initials: DS
authors.lastname: Chauhan
authors.affiliation: Department of Microbiology and NRL, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.
authors.forename: Prabha
authors.initials: P
authors.lastname: Desikan
mesh_terms: D024881:Drug Resistance, Bacterial; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics*; D011110:Polymorphism, Genetic; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology*