title: Polymorphisms of the lipoprotein lipase gene as genetic markers for stroke in colombian population: a case control study.
abstract: OBJECTIVE
  To analyze if there is an association between the presence of polymorphisms in theLPLgene (rs320, rs285 and rs328) with development of acute ischemic stroke in Colombian population.
  
  
  METHODS
  In a case control design, 133 acute ischemic stroke patients (clinical diagnosis and x-ray CT) and 269 subjects without stroke as controls were studied. PCR -RFLP technique was used to detect rs320, rs285 and rs328 polymorphisms in the LPL gene.
  
  
  RESULTS
  In the present research was not found any association between any of the LPL gene polymorphism and acute ischemic stroke in the population studied; the allele and genotypic frequencies of the studied polymorphisms were similar in cases and controls and followed the Hardy-Weinberg equilibrium. The study was approved by the IRB and each subject signed the informed consent.
  
  
  CONCLUSIONS
  LPL gene polymorphisms are not genetic markers for the development of stroke in the Colombian sample used.
authors.affiliation: Departamento de Ciencias Básicas, Facultad de Salud, Universidad Industrial de Santander, Bucaramenga, Colombia.
authors.forename: Leydi Carolina
authors.initials: LC
authors.lastname: Velásquez Pereira
authors.affiliation: Departamento de Ciencias Básicas, Facultad de Salud, Universidad Industrial de Santander, Bucaramenga, Colombia.
authors.forename: Clara Inés
authors.initials: CI
authors.lastname: Vargas Castellanos
authors.affiliation: Grupo de Ciencias Neurovasculares. Fundación Cardiovascular de Colombia, Bucaramanga, Colombia.
authors.forename: Federico Arturo
authors.initials: FA
authors.lastname: Silva Sieger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D003105:Colombia; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D020521:Stroke / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D008071:Lipoprotein Lipase
keywords: Colombia; Coronary Disease; Genotype; Lipoprotein Lipase; Lipoprotein lipase; Myocardial Infarction; Polymorphism Genetic; Polymorphism Single Nucleotide; Risk