title: Sleep Patterns and Neuropsychiatric Symptoms in Hospitalized Patients With Dementia.
abstract: The authors examined 28 dementia inpatients receiving treatment as usual. Beginning-to-end differences in neuropsychiatric symptoms and actigraphic sleep patterns were measured. Using a mixed-model, the authors regressed neuropsychiatric symptoms on average sleep minutes (between-subjects effect) and each night's deviation from average (within-subject effect). Sleep did not significantly differ from beginning to end of participation, whereas neuropsychiatric symptoms did. Average sleep minutes predicted average neuropsychiatric symptoms (p=0.002), but each night's deviation from the average did not predict next day's symptoms (p=0.90). These findings raise questions about the immediate benefits of treating sleep-wake disturbances on neuropsychiatric symptoms in hospitalized inpatients with dementias.
authors.affiliation: From the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (KST, RKP); and the Department of Psychiatry, University of Connecticut Health Center, Farmington, Conn. (AW).
authors.forename: Kaloyan S
authors.initials: KS
authors.lastname: Tanev
authors.affiliation: From the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (KST, RKP); and the Department of Psychiatry, University of Connecticut Health Center, Farmington, Conn. (AW).
authors.forename: Andrew
authors.initials: A
authors.lastname: Winokur
authors.affiliation: From the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (KST, RKP); and the Department of Psychiatry, University of Connecticut Health Center, Farmington, Conn. (AW).
authors.forename: Roger K
authors.initials: RK
authors.lastname: Pitman
mesh_terms: D056044:Actigraphy; D000369:Aged, 80 and over; D003704:Dementia / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007297:Inpatients; D008297:Male; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012890:Sleep / Q000502:physiology
keywords: Alzheimer-s Disease; Dementia; Mood Disorders (Neuropsychiatric Aspects); Sleep; Violence/Aggression