title: Association betweenHelicobacter pyloriand end-stage renal disease: A meta-analysis.
abstract: OBJECTIVE
  To investigate the prevalence and association ofHelicobacter pylori(H. pylori) with end-stage renal disease (ESRD).
  
  
  METHODS
  SA comprehensive literature search was completed from inception until October 2016. Studies that reported prevalence, relative risks, odd ratios, hazard ratios or standardized incidence ratio ofH. pyloriamong ESRD patients were included. Participants withoutH. pyloriwere used as comparators to assess the association betweenH. pyloriinfection and ESRD. Pooled risk ratios and 95%CI was calculated using a random-effect model. Adjusted point estimates from each study were combined by the generic inverse variance method of DerSimonian and Laird.
  
  
  RESULTS
  Of 4546 relevant studies, thirty-seven observational studies met all inclusion criteria. Thirty-five cross-sectional studies were included in the analyses to assess the prevalence and association ofH. pyloriwith ESRD. The estimated prevalence ofH. pyloriamong ESRD patients was 44% (95%CI: 40%-49%). The pooled RR ofH. pyloriin patients with ESRD was 0.77 (95%CI: 0.59-1.00) when compared with the patients without ESRD. Subgroup analysis showed significantly reduced risk ofH. pyloriin adult ESRD patients with pooled RR of 0.71 (95%CI: 0.55-0.94). The data on the risk of ESRD in patients withH. pyloriwere limited. Two cohort studies were included to assess the risk of ESRD in patients withH. pylori. The pooled risk RR of ESRD in patients withH. pyloriwas 0.61 (95%CI: 0.03-12.20).
  
  
  CONCLUSIONS
  The estimated prevalence ofH. pyloriin ESRD patients is 44%. Our meta-analysis demonstrates a decreased risk ofH. pyloriin adult ESRD patients.
authors.affiliation: Karn Wijarnpreecha, Charat Thongprayoon, Ridhmi Rajapakse, Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, United States.
authors.forename: Karn
authors.initials: K
authors.lastname: Wijarnpreecha
authors.affiliation: Karn Wijarnpreecha, Charat Thongprayoon, Ridhmi Rajapakse, Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, United States.
authors.forename: Charat
authors.initials: C
authors.lastname: Thongprayoon
authors.affiliation: Karn Wijarnpreecha, Charat Thongprayoon, Ridhmi Rajapakse, Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, United States.
authors.forename: Pitchaphon
authors.initials: P
authors.lastname: Nissaisorakarn
authors.affiliation: Karn Wijarnpreecha, Charat Thongprayoon, Ridhmi Rajapakse, Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, United States.
authors.forename: Natasorn
authors.initials: N
authors.lastname: Lekuthai
authors.affiliation: Karn Wijarnpreecha, Charat Thongprayoon, Ridhmi Rajapakse, Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, United States.
authors.forename: Veeravich
authors.initials: V
authors.lastname: Jaruvongvanich
authors.affiliation: Karn Wijarnpreecha, Charat Thongprayoon, Ridhmi Rajapakse, Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, United States.
authors.forename: Kiran
authors.initials: K
authors.lastname: Nakkala
authors.affiliation: Karn Wijarnpreecha, Charat Thongprayoon, Ridhmi Rajapakse, Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, United States.
authors.forename: Ridhmi
authors.initials: R
authors.lastname: Rajapakse
authors.affiliation: Karn Wijarnpreecha, Charat Thongprayoon, Ridhmi Rajapakse, Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, United States.
authors.forename: Wisit
authors.initials: W
authors.lastname: Cheungpasitporn
mesh_terms: D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology*; D008297:Male; D064887:Observational Studies as Topic; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors
keywords: End stage kidney disease; Helicobacter pylori; Kidney failure; Meta-analysis; Renal disease; Renal insufficiency