title: High-resolution dynamic oxygen-17 MR imaging of mouse brain with golden-ratio-based radial sampling and k-space-weighted image reconstruction.
abstract: OBJECTIVE
  The current study aimed to develop a three-dimensional (3D) dynamic oxygen-17 (17O) MR imaging method with high temporal and spatial resolution to delineate the kinetics of17O water uptake and washout in the brains of mice with glioblastoma (GBM).
  
  
  METHODS
  A 3D imaging method with a stack-of-stars golden-ratio-based radial sampling scheme was employed to acquire17O signal in vivo. A k-space-weighted image reconstruction method was used to improve the temporal resolution while preserving spatial resolution. Simulation studies were performed to validate the method. Using this method, the kinetics of17O water uptake and washout in the brains of mice with GBM were delineated after an intravenous bolus injection of17O water.
  
  
  RESULTS
  The proposed17O imaging method achieved an effective temporal resolution of 7.56 s with a nominal voxel size of 5.625 μL in the mouse brain at 9.4 T. Reduced uptake and prolonged washout of17O water were observed in tumor tissue, suggesting compromised cerebral perfusion.
  
  
  CONCLUSIONS
  This study demonstrated a promising dynamic17O imaging approach that can delineate17O water kinetics in vivo with high temporal and spatial resolution. It can also be used to image cerebral oxygen consumption rate in oxygen-17 inhalation studies. Magn Reson Med 79:256-263, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.|Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Yuchi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.|Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio, USA.|Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Chunying
authors.initials: C
authors.lastname: Wu
authors.affiliation: Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio, USA.|Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Junqing
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.|Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Charlie
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Tomko
authors.affiliation: Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Mikhail D
authors.initials: MD
authors.lastname: Linetsky
authors.affiliation: Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Salomon
authors.affiliation: Department of Neurology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Ciro
authors.initials: C
authors.lastname: Ramos-Estebanez
authors.affiliation: Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio, USA.|Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Yanming
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.|Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio, USA.|Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.|Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D003198:Computer Simulation; D003287:Contrast Media; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D007089:Image Enhancement; D007090:Image Interpretation, Computer-Assisted; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007700:Kinetics; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D008819:Mice, Nude; D010103:Oxygen Isotopes / Q000737:chemistry*; D019047:Phantoms, Imaging; D014867:Water / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D010103:Oxygen Isotopes; C000615258:Oxygen-17; D014867:Water
keywords: golden-ratio-based radial sampling; k-space-weighted image contrast reconstruction; oxygen-17 MRI