title: Catalytic topological insulator Bi2Se3nanoparticles for invivo protection against ionizing radiation.
abstract: Bi2Se3nanoparticles (NPs) have attracted wide interests in biological and medical applications. Layer-like Bi2Se3with high active surface area is promising for free radical scavenging. Here, we extended the medical applications of Bi2Se3NPs further to in vivo protection against ionizing radiation based on their superior antioxidant activities and electrocatalytic properties. It was found that Bi2Se3NPs can significantly increase the surviving fraction of mice after exposure of high-energy radiation of gamma ray. Additionally, the Bi2Se3NPs can help to recover radiation-lowered red blood cell counts, white blood cell counts and platelet levels. Further investigations revealed that Bi2Se3NPs behaved as functional free radical scavengers and significantly decreased the level of methylenedioxyamphetamine. In vivo toxicity studies showed that Bi2Se3NPs did not cause significant side effects in panels of blood chemistry, clinical biochemistry and pathology.
authors.affiliation: Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Science, Tianjin University, Tianjin, China; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China. Electronic address: xiaodongzhang@tju.edu.cn.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zhang
authors.affiliation: Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Science, Tianjin University, Tianjin, China.
authors.forename: Yaqi
authors.initials: Y
authors.lastname: Jing
authors.affiliation: Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Song
authors.affiliation: Environment, Energy and Natural Resources Center, Department of Environmental Science and Engineering, Fudan University, Shanghai, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Science, Tianjin University, Tianjin, China.
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
authors.forename: Xuhui
authors.initials: X
authors.lastname: Xue
authors.affiliation: Future Tech. Corporate R&D/LG Chem Research Park, Daejeon, Republic of Korea.
authors.forename: Yuho
authors.initials: Y
authors.lastname: Min
authors.affiliation: Department of Materials Science and Engineering, Cheongam-Ro 77, Pohang University of Science and Technology, Pohang, Republic of Korea.
authors.forename: Gyeongbae
authors.initials: G
authors.lastname: Park
authors.affiliation: Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Shen
authors.affiliation: Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China. Electronic address: yuanmings1962@163.com.
authors.forename: Yuan-Ming
authors.initials: YM
authors.lastname: Sun
authors.affiliation: Department of Materials Science and Engineering, Cheongam-Ro 77, Pohang University of Science and Technology, Pohang, Republic of Korea. Electronic address: ujeong@postech.ac.kr.
authors.forename: Unyong
authors.initials: U
authors.lastname: Jeong
mesh_terms: D000818:Animals; D002384:Catalysis; D016166:Free Radical Scavengers; D005720:Gamma Rays; D051379:Mice; D053758:Nanoparticles; D011839:Radiation, Ionizing; D011837:Radiation-Protective Agents
chemical_list: D016166:Free Radical Scavengers; D011837:Radiation-Protective Agents
keywords: Bi(2)Se(3); Free radical scavenging; Radiation protection