title: PGE2synthesis and signaling in malignant transformation and progression of human hepatocellular carcinoma.
abstract: Prostaglandin E 2 (PGE2), which is the most abundant prostaglandin produced in hepatocellular carcinoma (HCC), may be involved in hepatocarcinogenesis. Here, the amount of PGE2was significantly increased in HCC tissue and adjacent noncancerous tissues relative to normal liver tissue (P<.001). In addition, the expression of EP2 receptor was considerably upregulated in HCC tissue compared with the expression of EP1 (P<.05), EP3 (P<.01), and EP4 (P<.01) receptor. The expression of EP2 receptor was positively correlated with the level of PGE2in HCC tissue (P<.001). Furthermore, PGE2significantly increased proliferation and invasion potential of human HCC cells. However, antagonism of EP2 signaling suppressed PGE2-induced growth and invasion in human HCC cells. Taken together, upregulation of PGE2level was associated with proliferation and invasion potential of HCC, and EP2 receptor predominately mediated the function of PGE2in the transformation and progression of HCC.
authors.affiliation: Department of Pathology and Institute of Oncology, School of Basic Medical Science, Fujian Medical University, Fuzhou, 350004, China.
authors.forename: Shengbing
authors.initials: S
authors.lastname: Zang
authors.affiliation: Department of Pathology and Institute of Oncology, School of Basic Medical Science, Fujian Medical University, Fuzhou, 350004, China; Department of Pathology, Henan Provincial Chest Hospital, Zhengzhou, 450000, China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Hepatic Surgery, Liver Disease Center of the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Pathology and Institute of Oncology, School of Basic Medical Science, Fujian Medical University, Fuzhou, 350004, China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Pathology and Institute of Oncology, School of Basic Medical Science, Fujian Medical University, Fuzhou, 350004, China.
authors.forename: Haili
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Department of Pathology and Institute of Oncology, School of Basic Medical Science, Fujian Medical University, Fuzhou, 350004, China.
authors.forename: Jiasi
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Hepatic Surgery, Liver Disease Center of the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pathology and Institute of Oncology, School of Basic Medical Science, Fujian Medical University, Fuzhou, 350004, China. Electronic address: draimin@163.com.
authors.forename: Aimin
authors.initials: A
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology; D015232:Dinoprostone / Q000096:biosynthesis*; D018450:Disease Progression; D005260:Female; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D058307:Receptors, Prostaglandin E, EP2 Subtype / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D000970:Antineoplastic Agents; C545644:PTGER2 protein, human; D058307:Receptors, Prostaglandin E, EP2 Subtype; D015232:Dinoprostone
keywords: Antagonism; E prostanoid receptor; Hepatocellular carcinoma; Proliferation; Prostaglandin E 2 (PGE(2))