title: In situ memory T cells and patterns of invasion predict outcome in patients with early-stage oral squamous cell carcinoma.
abstract: OBJECTIVE
  The objective of this study was to explore the prognostic value of in situ memory T cells and patterns of invasion (POI) in early stage oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  One hundred fifty-seven patients with early stage (cT1T2N0) OSCC were identified from a pre-existing database of patients with oral cancer and were classified by POI according to hematoxylin-eosin staining. We examined the impact of the immunohistochemical expression of CD45RO in OSCC. Overall survival (OS) curves were calculated using the Kaplan-Meier method.
  
  
  RESULTS
  Margin status was significantly associated with local recurrence in early stage OSCC (p= 0.000), and depth of invasion was also associated with regional recurrence (2 mm: p= 0.034; 4 mm: p= 0.015). The expression of CD45RO (p= 0.021) and POI (p= 0.027) individually was associated with OS, and patients in the group with combination score tended to have worse OS (p= 0.012).
  
  
  CONCLUSIONS
  Combined evaluation of POI and CD45RO might prove to be a useful indicator for high-risk patients with occult metastases from early stage OSCC.
authors.affiliation: Department of Oral Pathology, Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, Heilongjiang, China.
authors.forename: Jiankai
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Oral Pathology, Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Meng
authors.affiliation: Department of Oral Pathology, Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China.
authors.forename: Dongxia
authors.initials: D
authors.lastname: Qiang
authors.affiliation: Department of Oral Pathology, Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China.
authors.forename: Changsheng
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Oral Pathology, Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Oral Pathology, Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China.
authors.forename: Eryang
authors.initials: E
authors.lastname: Zhao
mesh_terms: D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D015996:Survival Rate; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: CD45RO; early stage; oral squmaous cell cacinoma; patterns of invasion