title: Hypertensive disorders of pregnancy in women with gestational diabetes mellitus on overweight status of their children.
abstract: Hypertensive disorders of pregnancy (HDP) as a group of medical complications in pregnancy are believed to be associated with an increased risk of poor fetal growth, but the influence on offspring's body composition is not clear. The aim of the present study was to evaluate the association between maternal HDP and overweight status in the offspring of mothers with gestational diabetes mellitus (GDM). A cross-sectional study among 1263 GDM mother-child pairs was performed in Tianjin, China. General linear models and logistic regression models were used to assess the associations of maternal hypertension in pregnancy with anthropometry and overweight status in the offspring from birth to 1-5 years old. Offspring of GDM mothers who were diagnosed with hypertensive disorders during pregnancy had higher mean values of Z-scores for birth weight for gestational age and birth weight for length, and higher mean values of Z-scores for weight for age, weight for length/height, and body mass index for age at 1-5 years old than those of GDM mothers with normal blood pressure during pregnancy. Maternal HDP were associated with increased risks of large for gestational age (OR 1.74, 95% CI 1.08-2.79) and macrosomia (OR 2.02, 95% CI 1.23-3.31) at birth and childhood overweight/obesity at 1-5 years old age (OR 1.88, 95% CI 1.16-3.04). For offspring of mothers with GDM, maternal hypertension during pregnancy was a risk factor for macrosomia at birth and childhood overweight and obesity, and controlling the maternal hypertension may be more important for preventing large-for-gestational-age babies and childhood obesity.
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin, China.
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin, China.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin, China.
authors.forename: J
authors.initials: J
authors.lastname: Leng
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin, China.
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin, China.
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin, China.|Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin, China.
authors.forename: N
authors.initials: N
authors.lastname: Li
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin, China.
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.affiliation: Tianjin Women's and Children's Health Center, Tianjin, China.
authors.forename: H
authors.initials: H
authors.lastname: Tian
authors.affiliation: Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Baccarelli
authors.affiliation: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: L
authors.initials: L
authors.lastname: Hou
authors.affiliation: Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
authors.forename: G
authors.initials: G
authors.lastname: Hu
mesh_terms: D050154:Adiposity; D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D063766:Pediatric Obesity / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors; D013997:Time Factors; D015430:Weight Gain
chemical_list: D015415:Biomarkers; D001786:Blood Glucose