title: Prostate transitional zone volume-based nomogram for predicting prostate cancer and high progression prostate cancer in a real-world population.
abstract: OBJECTIVE
  To evaluate and compare the efficacy of prostate volume (PV), transitional zone volume (TZV), and prostate volume index (PVI, the ratio of TZV to peripheral zone volume) in the identification of men at risk of prostate cancer (PCa) and high-progression PCa (HPPCa) at the initial biopsy (IBX) in a real-world population.
  
  
  METHODS
  From Jul 2014 to Aug 2016, data on 1144 patients who had undergone the initial prostate biopsies were prospectively collected and analyzed. Univariate and multivariate logistic regression analyses were performed to identify the independent predictors for PCa and HPPCa. Based on independent predictors, nomogram models were developed and internally validated to assess a man's risk of harboring PCa and HPPCa.
  
  
  RESULTS
  The detection rates of PCa and HPPCa were 43.09% (493/1144) and 39.16% (448/1144), respectively. In the multivariate analyses, age, PSA, TZV, DRE, and TRUS instead of PV or PVI were independent predictors for PCa and HPPCa, percent free PSA was independent predictor for PCa not for HPPCa. Such independent predictors were finally included in the nomogram models. The AUCs of TZV-based nomogram models were 87.0% for PCa and 87.7% for HPPCa, which were higher than that of PSA alone or other predictive models.
  
  
  CONCLUSIONS
  TZV is a better predictive biomarker than PV or PVI for PCa and HPPCa, we recommend adding TZV but not PV or PVI to the nomogram models to improve the predictive accuracy of PCa and HPPCa at IBX.
authors.affiliation: Department of Urology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Urology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China.|Department of Ultrasound, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Shaowei
authors.initials: S
authors.lastname: Xie
authors.affiliation: Department of Urology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China.
authors.forename: Xun
authors.initials: X
authors.lastname: Shangguan
authors.affiliation: Department of Urology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China.
authors.forename: Jiahua
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of Urology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China.
authors.forename: Yinjie
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Urology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China.
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Xin
authors.affiliation: Department of Urology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China.
authors.forename: Fan
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Urology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Shao
authors.affiliation: Department of Urology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China.
authors.forename: Liancheng
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Urology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Sha
authors.affiliation: Department of Pathology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Urology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China. dongbaijun@renji.com.
authors.forename: Baijun
authors.initials: B
authors.lastname: Dong
authors.affiliation: Department of Urology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China. xuewei@renji.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Xue
mesh_terms: D000368:Aged; D019540:Area Under Curve; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D049451:Nomograms; D011471:Prostatic Neoplasms / Q000473:pathology*; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity
keywords: Biopsy; Nomogram; Prostatic neoplasm; Transitional zone volume