title: [A Case of a Pituitary Adenoma Diagnosed as Carney Complex Syndrome in an Older Female Patient].
abstract: Carney complex syndrome is an autosomal dominant familial tumor syndrome first described by Carney et al. in 1985. The diagnostic criteria include endocrine hyperactivity and spotty skin pigmentation. A 73-year-old woman with cerebral infarction was referred to our department because her brain magnetic resonance imaging(MRI)revealed a pituitary tumor. Her blood tests revealed elevated levels of growth hormone(GH), thyroid stimulating hormone(TSH), and insulin-like growth factor-1(IGF-1). We suspected the presence of a GH-secreting tumor and performed the operation. The pathological finding was a TSH-positive pituitary adenoma. Her cervical computed tomography(CT)revealed a thyroid tumor and the tumor removal was performed. The pathological diagnosis was papillary carcinoma. She had skin pigmentation bilaterally on her face, forearms, hands, and legs. We diagnosed this case as Carney complex syndrome based on these findings.
authors.affiliation: Department of Neurosurgery, Osaka Police Hospital.
authors.forename: Ai
authors.initials: A
authors.lastname: Okamoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Wajima
authors.forename: Rinsei
authors.initials: R
authors.lastname: Tei
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shin
authors.forename: Misato
authors.initials: M
authors.lastname: Inoue
authors.forename: Shuta
authors.initials: S
authors.lastname: Aketa
authors.forename: Taiji
authors.initials: T
authors.lastname: Yonezawa
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D000368:Aged; D001921:Brain / Q000473:pathology; D056733:Carney Complex / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D019382:Human Growth Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D012867:Skin / Q000473:pathology
chemical_list: D019382:Human Growth Hormone; C406545:pegvisomant