title: Chemical composition and biological properties ofSatureja avromanicaMaroofi.
abstract: Satureja avromanicais an indigenous plant which is frequently used as a spice in Avraman-Kurdistan region of Iran. The present study aimed to investigate the chemical composition, antimicrobial and antioxidant properties of theS. avromanica. In addition, rosmarinic acid and total phenolic content ofS. avromanicawas assessed by spectrophotometric method and HPTLC. The essential oil and methanolic extract were isolated by hydrodistillation and maceration methods, respectively. A total of 32 compounds representing 98.6% of the essential oil were identified by GC-MS and GC-FID. The main constituents weren-pentacosane (23.8%), spathulenol (11.5%), β-bourbonen (11.3%) andn-docosane (11.0%). The antibacterial activity of samples were carried out by disc diffusion method and evaluate the minimal inhibitory concentration (MIC) essential oil and methanolic extract were found to be effective againstStaphylococcus aureus,Bacillus cereusandBacillus pumilus. The highest scavenging activity was found for methanolic extract ofS. avromanica(21.58 µg/mL) and the total phenolics of methanolic extract ofS. avromanicawas 95.3 mg GAE/g. The rosmarinic acid content ofS. avromanicamethanolic extract was 0.83 mg/g plant. Antioxidant activity and rosmarininc acid content ofS. avromanicasuggests that the essential oil and methanolic extract ofS. avromanicahas great potential for application as a natural antimicrobial and antioxidant agent to preserve food.
authors.affiliation: Department of Toxicology and Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Abdali
authors.affiliation: Department of Toxicology and Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Javadi
authors.affiliation: Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Akhgari
authors.affiliation: Department of Nutrition, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Seyran
authors.initials: S
authors.lastname: Hosseini
authors.affiliation: Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.|Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Dara
authors.initials: D
authors.lastname: Dastan
keywords: Antimicrobial; Antioxidant; Essential oil; Rosmarinic acid; Satureja avromanica; Spice