title: Association between Cataract and Keratinocytic Skin Cancers or Melanoma: Speculating on the Common Role of Sun and Ultraviolet Radiation Exposures.
abstract: Cataract and sun-related skin conditions are proxies to lifetime UV exposure. We examined the association between them using real-world data from an unselected Israeli population.
  
  
  
  Computerized data was obtained from an Israeli health maintenance organization regarding cases of sun-related skin pathologies and cataract diagnosed between 2006 and 2011 in 686,260 members aged 40 or above.
  
  
  
  Sun-related skin disorders were found in 9.3% of the study population, more commonly among the elderly, and those who reside in areas of higher socioeconomic status. Cataract was diagnosed in 13.1% of the study population, with highest prevalence (47%) among squamous cell carcinoma patients, who were the oldest group. Multivariable analysis adjusting for age, sex, residential district, birth region, smoking, and chronic comorbidities showed no statistically significant association between melanoma and cataract (OR = 1.06; 95% CI: 0.91-1.22). Basal cell carcinoma, squamous cell carcinomas, and actinic keratosis were associated with increased likelihood of prevalent cataract with adjusted odds ratios (95% CI) of 1.14 (1.08-1.20), 1.11 (1.01-1.19), and 1.16 (1.13-1.19), respectively. When stratified by gender, the association between actinic keratosis and cataract was stronger in women than in men, particularly in patients under 65 years.
  
  
  
  The association between the prevalence of skin cancers and the prevalence of cataract enhances the conclusion that cataract is related to UVR exposure.
authors.affiliation: a Department of Ophthalmology , Tel Aviv Sourasky Medical Center , Tel Aviv , Israel.|b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
authors.forename: David
authors.identifier: 0000-0002-1704-8145
authors.initials: D
authors.lastname: Varssano
authors.affiliation: c Medical Division , Maccabi Healthcare Services , Tel Aviv , Israel.
authors.forename: Mira
authors.initials: M
authors.lastname: Friedman
authors.affiliation: a Department of Ophthalmology , Tel Aviv Sourasky Medical Center , Tel Aviv , Israel.|b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
authors.forename: Michaella
authors.initials: M
authors.lastname: Goldstein
authors.affiliation: a Department of Ophthalmology , Tel Aviv Sourasky Medical Center , Tel Aviv , Israel.|b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
authors.forename: Shai
authors.initials: S
authors.lastname: Bar-Sela
authors.affiliation: c Medical Division , Maccabi Healthcare Services , Tel Aviv , Israel.|d Department of Oncology , Sheba Medical Center , Tel Hashomer , Israel.
authors.forename: Tal
authors.initials: T
authors.lastname: Sella
authors.affiliation: b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.|c Medical Division , Maccabi Healthcare Services , Tel Aviv , Israel.
authors.forename: Varda
authors.initials: V
authors.lastname: Shalev
authors.affiliation: b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.|c Medical Division , Maccabi Healthcare Services , Tel Aviv , Israel.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Chodick
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D002386:Cataract / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D055623:Keratosis, Actinic / Q000453:epidemiology*; D008297:Male; D008545:Melanoma / Q000453:epidemiology*; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D015995:Prevalence; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000453:epidemiology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
keywords: Actinic keratosis; Israel; cataract; melanoma; skin cancer