title: Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis.
abstract: Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility. Secondly, among the 897 GC patients above, 755 cases underwent a radical operation, without distant metastasis and with negative surgical margins included in the survival analysis to evaluate the association of the four SNPs above with gastric cancer prognosis. The C/T or C/C genotypes of rs213210 were related to a lower GC risk (OR = 0.76, 95% CI: 0.62-0.93,P= 0.009) compared to the T/T genotype. Rs11134527 in miR-218 was associated with GC survival, and the G/A and G/G genotypes of rs11134527 resulted in a decreased risk of death when compared with the A/A genotype (HR = 0.75, 95% CI: 0.61-0.95,P= 0.016). This study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis.
authors.affiliation: Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province 130021, China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province 130021, China.
authors.forename: Zhifang
authors.identifier: 0000-0001-9838-1726
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province 130021, China.
authors.forename: Donghui
authors.identifier: 0000-0002-6795-6395
authors.initials: D
authors.lastname: Cao
authors.affiliation: Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province 130021, China; Maternal and Child Health Center of Chaoyang District, Beijing 100020, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province 130021, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Wu
authors.affiliation: Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province 130021, China.
authors.forename: Lili
authors.initials: L
authors.lastname: You
authors.affiliation: Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province 130021, China.
authors.forename: Simin
authors.initials: S
authors.lastname: Wen
authors.affiliation: Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province 130021, China.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Xueyuan
authors.identifier: 0000-0002-1982-1672
authors.initials: X
authors.lastname: Cao
authors.affiliation: Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province 130021, China.
authors.forename: Jing
authors.identifier: 0000-0001-9714-9255
authors.initials: J
authors.lastname: Jiang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs