title: First experiences with model based iterative reconstructions influence on quantitative plaque volume and intensity measurements in coronary computed tomography angiography.
abstract: Investigate the influence of adaptive statistical iterative reconstruction (ASIR) and the model-based IR (Veo) reconstruction algorithm in coronary computed tomography angiography (CCTA) images on quantitative measurements in coronary arteries for plaque volumes and intensities.
  
  
  
  Three patients had three independent dose reduced CCTA performed and reconstructed with 30% ASIR (CTDIvolat 6.7 mGy), 60% ASIR (CTDIvol4.3 mGy) and Veo (CTDIvolat 1.9 mGy). Coronary plaque analysis was performed for each measured CCTA volumes, plaque burden and intensities.
  
  
  
  Plaque volume and plaque burden show a decreasing tendency from ASIR to Veo as median volume for ASIR is 314 mm3and 337 mm3-252 mm3for Veo and plaque burden is 42% and 44% for ASIR to 39% for Veo. The lumen and vessel volume decrease slightly from 30% ASIR to 60% ASIR with 498 mm3-391 mm3for lumen volume and vessel volume from 939 mm3to 830 mm3. The intensities did not change overall between the different reconstructions for either lumen or plaque.
  
  
  
  We found a tendency of decreasing plaque volumes and plaque burden but no change in intensities with the use of low dose Veo CCTA (1.9 mGy) compared to dose reduced ASIR CCTA (6.7 mGy & 4.3 mGy), although more studies are warranted.
authors.affiliation: Odense University Hospital Svendborg, Medical Research Department, Valdemarsgade 53, 5700 Svendborg, Denmark; Conrad Research Center, University College Lillebelt, Niels Bohrs Allé 1, 5230 Odense M, Denmark. Electronic address: hepr@ucl.dk.
authors.forename: H
authors.initials: H
authors.lastname: Precht
authors.affiliation: Leiden University Medical Center, Department of Radiology, Division of Image Processing, Albinusdreef 2, 2300 RC Leiden, The Netherlands; Medis Medical Imaging Systems B.V, Schuttersveld 9, 2300 AJ Leiden, The Netherlands.
authors.forename: P H
authors.initials: PH
authors.lastname: Kitslaar
authors.affiliation: Leiden University Medical Center, Department of Radiology, Division of Image Processing, Albinusdreef 2, 2300 RC Leiden, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Broersen
authors.affiliation: Odense University Hospital, Department of Nuclear Medicine, Sdr. Boulevard 29, 5000 Odense C, Denmark; University of Southern Denmark, Centre of Health Economics Research, Campusvej 55, 5230 Odense M, Denmark.
authors.forename: O
authors.initials: O
authors.lastname: Gerke
authors.affiliation: Leiden University Medical Center, Department of Radiology, Division of Image Processing, Albinusdreef 2, 2300 RC Leiden, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Dijkstra
authors.affiliation: Århus University Hospital, Department of Clinical Engineering, Brendstrupgaardsvej 100, 8200 Århus N, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Thygesen
authors.affiliation: Odense University Hospital Svendborg, Medical Research Department, Valdemarsgade 53, 5700 Svendborg, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Egstrup
authors.affiliation: Odense University Hospital Svendborg, Medical Research Department, Valdemarsgade 53, 5700 Svendborg, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Lambrechtsen
mesh_terms: D000368:Aged; D000465:Algorithms; D000072226:Computed Tomography Angiography / Q000379:methods*; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: Cardiac CT; Image quality; Iterative reconstructions; MBIR; Plaque analysis; Veo