title: Platelet Count in First Trimester of Pregnancy as a Predictor of Perinatal Outcome.
abstract: OBJECTIVE
  To rule out maternal and pregnancy factors that may contribute to platelet count (PLT) changes in the first trimester of gestation and examine if there is any association between its levels and adverse perinatal outcome.
  
  
  METHODS
  The study population included all patients from the first-trimester visit between 2013-2015 with pregnancy results. Linear multiple regression was constructed to rule out variables that may have a significant contribution to PLT. For each adverse outcome at birth, multiple logistic regression analysis was implemented to estimate the PLT effect.
  
  
  RESULTS
  PLT was measured in 6092 patients. There was the significant contribution on PLT in the first trimester from maternal weight, the presence of rheumatologic disease, BHCG levels and MPV. There was a significant association between PLT and abnormal cardiotocography at delivery (OR 1.004; IC95% 1.001 to 1.007) and C-Section due to abnormal CTG (OR 1.005; IC95% 1.002 to 1.008). When adjusted for factors that interact with PLT there was also a significant association with pH at birth < 7.10 and gestational diabetes.
  
  
  CONCLUSIONS
  Maternal and pregnancy factors can poorly predict relevant changes in PLT at the first trimester of gestation. PLT at first trimester of pregnancy might predict adverse perinatal outcome in combination with other markers.
authors.affiliation: Department of Obstetrics and Gynecology, Hospital General, Universitario Gregorio Marañon de Madrid, Madrid, Spain.
authors.forename: Santiago Garcia-Tizon
authors.initials: SG
authors.lastname: Larroca
authors.affiliation: Department of Internal Medicine, Hospital Universitario, Principe de Asturias de Alcalá de Henares, Madrid, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Arevalo-Serrano
authors.affiliation: Department of Obstetrics and Gynecology, Hospital General, Universitario Gregorio Marañon de Madrid, Madrid, Spain.
authors.forename: Virginia Ortega
authors.initials: VO
authors.lastname: Abad
authors.affiliation: Department of Obstetrics and Gynecology, Hospital General, Universitario Gregorio Marañon de Madrid, Madrid, Spain.
authors.forename: Pilar Pintado
authors.initials: PP
authors.lastname: Recarte
authors.affiliation: Department of Obstetrics and Gynecology, Hospital General, Universitario Gregorio Marañon de Madrid, Madrid, Spain.
authors.forename: Alejandro Garcia
authors.initials: AG
authors.lastname: Carreras
authors.affiliation: Department of Obstetrics and Gynecology, Hospital General, Universitario Gregorio Marañon de Madrid, Madrid, Spain.
authors.forename: Gonzalo Nozaleda
authors.initials: GN
authors.lastname: Pastor
authors.affiliation: Department of Obstetrics and Gynecology, Hospital General, Universitario Gregorio Marañon de Madrid, Madrid, Spain.
authors.forename: Cesar Rodriguez
authors.initials: CR
authors.lastname: Hernandez
authors.affiliation: Department of Obstetrics and Gynecology, Hospital General, Universitario Gregorio Marañon de Madrid, Madrid, Spain.
authors.forename: Ricardo Perez Fernandez
authors.initials: RP
authors.lastname: Pacheco
authors.affiliation: Department of Obstetrics and Gynecology, Hospital General, Universitario Gregorio Marañon de Madrid, Madrid, Spain.
authors.forename: Juan De Leon
authors.initials: JL
authors.lastname: Luis
keywords: Platelet Count; Pregnancy Outcome; Pregnancy Trimester First