title: Critical role of HMGA proteins in cancer cell chemoresistance.
abstract: The high-mobility group A (HMGA) proteins are frequently overexpressed in human malignancies and correlate with the presence of metastases and reduced patient survival. Here, we highlight the main studies evidencing a critical role of HMGA in chemoresistance, mainly by activating Akt signaling, impairing p53 activity, and regulating the expression of microRNAs that target genes involved in the susceptibility of cancer cells to antineoplastic agents. Therefore, these studies account for the association of HMGA overexpression with patient poor outcome, indicating the impairment of HMGA as a fascinating perspective for effectively improving cancer therapy.
authors.affiliation: Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Via Pansini 5, 80131, Naples, Italy. daniela.dangelo@unina.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: D'Angelo
authors.affiliation: Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Via Pansini 5, 80131, Naples, Italy.
authors.forename: Paula
authors.initials: P
authors.lastname: Mussnich
authors.affiliation: Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale", IRCCS, Naples, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Arra
authors.affiliation: Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Via Pansini 5, 80131, Naples, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Battista
authors.affiliation: Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Via Pansini 5, 80131, Naples, Italy. alfusco@unina.it.|Dipartimento di Medicina Molecolare e, Biotecnologie Mediche (DMMBM), Università degli Studi di Napoli "Federico II", Via Pansini 5, 80131, Naples, Italy. alfusco@unina.it.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Fusco
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D024003:HMGA Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D024003:HMGA Proteins; D035683:MicroRNAs; D051057:Proto-Oncogene Proteins c-akt
keywords: Apoptosis; Chemoresistance; DNA repair; HMGA; miRNAs