title: Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering.
abstract: Ischemic stroke continues to be a leading cause of morbidity and mortality throughout the world. To protect and/or repair the ischemic brain, a multitiered approach may be centered on neural stem cell (NSC) transplantation. Transplanted NSCs exert beneficial effects not only via structural replacement, but also via immunomodulatory and/or neurotrophic actions. Unfortunately, the clinical translation of such promising therapies remains elusive, in part due to their limited persistence/survivability within the hostile ischemic microenvironment. Herein, we discuss current approaches for the development of NSCs more amenable to survival within the ischemic brain as a tool for future cellular therapies in stroke.
authors.affiliation: 1 Department of Clinical Neurosciences, Division of Stem Cell Neurobiology, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.|2 Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, MD, USA.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Bernstock
authors.affiliation: 1 Department of Clinical Neurosciences, Division of Stem Cell Neurobiology, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.
authors.forename: Luca
authors.initials: L
authors.lastname: Peruzzotti-Jametti
authors.affiliation: 2 Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, MD, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ye
authors.affiliation: 1 Department of Clinical Neurosciences, Division of Stem Cell Neurobiology, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.
authors.forename: Florian A
authors.initials: FA
authors.lastname: Gessler
authors.affiliation: 2 Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, MD, USA.
authors.forename: Dragan
authors.initials: D
authors.lastname: Maric
authors.affiliation: 1 Department of Clinical Neurosciences, Division of Stem Cell Neurobiology, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.
authors.forename: Nunzio
authors.initials: N
authors.lastname: Vicario
authors.affiliation: 2 Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, MD, USA.
authors.forename: Yang-Ja
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: 1 Department of Clinical Neurosciences, Division of Stem Cell Neurobiology, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.
authors.forename: Stefano
authors.initials: S
authors.lastname: Pluchino
authors.affiliation: 2 Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, MD, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Hallenbeck
mesh_terms: D002545:Brain Ischemia / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D060846:Cell Engineering / Q000379:methods*; D002470:Cell Survival; D006801:Humans; D058953:Neural Stem Cells / Q000276:immunology / Q000473:pathology / Q000637:transplantation*; D033581:Stem Cell Transplantation / Q000379:methods*; D020521:Stroke / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D019172:Transplantation Conditioning / Q000379:methods*
keywords: Ischemic stroke; cellular engineering; neural stem cells; post-translational modifications; preconditioning