title: Distribution of androgenetic cells in fetal mouse chimeras.
abstract: To asses the potential of androgenetic cells to participate in post-midgestation fetal development we have made use of an in situ detectable cell lineage marker in the analysis of chimeric mouse fetuses containing an androgenetic cell lineage. Our results show conclusively that androgenetic cells participate in the formation of derivatives of all lineages and in some tissues may contribute the majority of the total cell population. However, the allocation or persistence of androgenetic cells was non-random. High contribution of androgenetic cells was observed in brown adipose tissue, mesenchyme, smooth muscle, perichondrium, peripheral nerves and epithelia of the intestinal tract and the trachea. Thus, androgenetic cells were able to efficiently populate mesodermal, ectodermal and endodermal derivatives. In contrast, there was a clear prejudice against androgenetic cells in the brain.
authors.affiliation: Institut für Biologie III der Universität Freiburg, Schänzlestraße 1, D-79104, Freiburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Fundele
authors.affiliation: Institut für Biologie III der Universität Freiburg, Schänzlestraße 1, D-79104, Freiburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Krause
authors.affiliation: Wellcome/CRC Institute of Cancer and Developmental Biology, Tennis Court Road, CB2 lQR, Cambridge.|Physiological Laboratory, University of Cambridge, UK.
authors.forename: S C
authors.initials: SC
authors.lastname: Barton
authors.affiliation: Wellcome/CRC Institute of Cancer and Developmental Biology, Tennis Court Road, CB2 lQR, Cambridge.|Physiological Laboratory, University of Cambridge, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Surani
authors.affiliation: Institut für Anatomic der Universität Freiburg, Albertstraße 17, D-79104, Freiburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Christ
keywords: Androgenesis; Imprinting; Mouse chimeras