title: Diagnosis and treatment of antiphospholipid syndrome in childhood: A review.
abstract: The antiphospholipid syndrome (APS) is a multisystem autoimmune disease characterized by recurrent fetal loss and thromboembolic events associated with the presence of elevated titres of antiphospholipid antibodies (aPL). The purpose of this review is to summarize what is currently known about the diagnosis and treatment of pediatric APS, to highlight key differences between APS presenting in adults versus children throughout, and to identify areas where future research is needed.
authors.affiliation: Department of Pediatrics, University of Alberta, 11405 87 Ave NW, Edmonton, AB T6G 1C9, Canada. Electronic address: Rumsey@ualberta.ca.
authors.forename: Dax G
authors.initials: DG
authors.lastname: Rumsey
authors.affiliation: Pediatric Rheumatology, 2119 Plantation Bend Drive, Sugar Land, TX 77478, USA.
authors.forename: Barry
authors.initials: B
authors.lastname: Myones
authors.affiliation: Department of Pediatrics, University of Alberta, 11405 87 Ave NW, Edmonton, AB T6G 1C9, Canada.
authors.forename: Patti
authors.initials: P
authors.lastname: Massicotte
mesh_terms: D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D002648:Child; D006801:Humans; D010372:Pediatrics; D012307:Risk Factors; D013927:Thrombosis / Q000453:epidemiology / Q000517:prevention & control; D016896:Treatment Outcome
keywords: Diagnosis; Neonatal thrombosis; Pediatric antiphospholipid syndrome; Pediatric catastrophic antiphospholipid syndrome; Treatment