title: Enantioselective Bioaccumulation, Tissue Distribution, and Toxic Effects of Myclobutanil Enantiomers in Pelophylax nigromaculatus Tadpole.
abstract: Research on the enantioselective behavior of chiral pesticides on amphibians has received growing attention, because amphibians are experiencing a population decline and amphibian metamorphosis shares many similarities with human fetal development. In this study, the enantioselective behavior of myclobutanil on Pelophylax nigromaculatus tadpole was studied. The antioxidant enzyme (SOD, GST) activities and malondialdehyde (MDA) content were investigated to assess the different toxic effects when tadpoles were exposed to myclobutanil enantiomers for 96 h. In the chronic exposure experiment, the bioaccumulation concentration of (-)-myclobutanil in tadpoles is significantly higher than that of (+)-myclobutanil, and the concentration of myclobutanil in tadpole intestine and liver was higher compared with other tissues. During the elimination experiment, about 95% of myclobutanil in tadpoles was eliminated within only 24 h. On the basis of these data, the enantiomeric differences should be taken into consideration in the risk assessment of myclobutanil.
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University , Yuanmingyuan West Road 2, Beijing 100193, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University , Yuanmingyuan West Road 2, Beijing 100193, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Di
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University , Yuanmingyuan West Road 2, Beijing 100193, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University , Yuanmingyuan West Road 2, Beijing 100193, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University , Yuanmingyuan West Road 2, Beijing 100193, China.
authors.forename: Jinling
authors.initials: J
authors.lastname: Diao
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University , Yuanmingyuan West Road 2, Beijing 100193, China.
authors.forename: Zhiqiang
authors.identifier: http://orcid.org/0000-0002-0816-6203
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007814:Larva / Q000254:growth & development / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D009570:Nitriles / Q000737:chemistry* / Q000378:metabolism*; D010575:Pesticides / Q000737:chemistry* / Q000378:metabolism*; D011898:Ranidae / Q000254:growth & development* / Q000378:metabolism; D013237:Stereoisomerism; D014018:Tissue Distribution; D014230:Triazoles / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D009570:Nitriles; D010575:Pesticides; D014230:Triazoles; D008315:Malondialdehyde; C446685:systhane
keywords: bioaccumulation; enantioselective; myclobutanil; tadpole; toxic effect