title: Cross-Lagged Panel Analysis of Depression and Behavioral Dysfunction in the First Year After Moderate-to-Severe Traumatic Brain Injury.
abstract: Timely treatment of depression and behavioral dysfunction after moderate-to-severe traumatic brain injury (TBI) could improve health, function, and quality of life. The authors hypothesized that 6-month depression would be the stronger contributor to later depression and behavioral dysfunction in a sample of 88 adults with moderate-to-severe TBI. A structural equation modeling cross-lagged panel analysis, adjusting for all 6-month predictors, revealed that 6-month depression had a stronger relationship to 12-month depression (βstand=0.55, p=0.002) and behavioral dysfunction (βstand=0.41, p=0.004) than did 6-month behavioral dysfunction (βstand=0.17, p=0.270, βstand=0.30, p=0.035). Depression may be in the developmental pathway to behavioral dysfunction, triggering a cycle of reciprocal causality.
authors.affiliation: From the Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh (S.B.J., J.M.M., A.K.W.); and the Departments of Psychiatry and Behavioral Sciences, Rehabilitation Medicine, and Epidemiology, University of Washington, Seattle (J.R.F.).
authors.forename: Shannon B
authors.initials: SB
authors.lastname: Juengst
authors.affiliation: From the Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh (S.B.J., J.M.M., A.K.W.); and the Departments of Psychiatry and Behavioral Sciences, Rehabilitation Medicine, and Epidemiology, University of Washington, Seattle (J.R.F.).
authors.forename: John M
authors.initials: JM
authors.lastname: Myrga
authors.affiliation: From the Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh (S.B.J., J.M.M., A.K.W.); and the Departments of Psychiatry and Behavioral Sciences, Rehabilitation Medicine, and Epidemiology, University of Washington, Seattle (J.R.F.).
authors.forename: Jesse R
authors.initials: JR
authors.lastname: Fann
authors.affiliation: From the Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh (S.B.J., J.M.M., A.K.W.); and the Departments of Psychiatry and Behavioral Sciences, Rehabilitation Medicine, and Epidemiology, University of Washington, Seattle (J.R.F.).
authors.forename: Amy K
authors.initials: AK
authors.lastname: Wagner
mesh_terms: D000328:Adult; D000070642:Brain Injuries, Traumatic / Q000150:complications* / Q000523:psychology*; D015331:Cohort Studies; D003863:Depression / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000209:etiology*; D011569:Psychiatric Status Rating Scales; D057566:Self Report
keywords: Behavioral Therapy (Neuropsychiatric Aspects); Depression; Traumatic Brain Injury