title: Sex-specific cognitive abnormalities in early-onset psychosis.
abstract: Brain maturation differs depending on the area of the brain and sex. Girls show an earlier peak in maturation of the prefrontal cortex. Although differences between adult females and males with schizophrenia have been widely studied, there has been less research in girls and boys with psychosis. The purpose of this study was to examine differences in verbal and visual memory, verbal working memory, auditory attention, processing speed, and cognitive flexibility between boys and girls.
  We compared a group of 80 boys and girls with first-episode psychosis to a group of controls.
  We found interactions between group and sex in verbal working memory (p = 0.04) and auditory attention (p = 0.01). The female controls showed better working memory (p = 0.01) and auditory attention (p = 0.001) than males. However, we did not find any sex differences in working memory (p = 0.91) or auditory attention (p = 0.93) in the psychosis group.
  These results are consistent with the presence of sex-modulated cognitive profiles at first presentation of early-onset psychosis.
authors.affiliation: Grupo Psicosis y Neurodesarrollo, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Sevilla, Unidad de Hospitalizacion de Salud Mental, Sevilla, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Ruiz-Veguilla
authors.affiliation: Grupo Psicosis y Neurodesarrollo, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Sevilla, Unidad de Hospitalizacion de Salud Mental, Sevilla, Spain.
authors.forename: Josefa
authors.initials: J
authors.lastname: Moreno-Granados
authors.affiliation: Grupo Psicosis y Neurodesarrollo, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Sevilla, Unidad de Hospitalizacion de Salud Mental, Sevilla, Spain.
authors.forename: Maria D
authors.initials: MD
authors.lastname: Salcedo-Marin
authors.affiliation: Departamento de Psiquiatría, ISS Fundación Jiménez Díaz, Universidad Autónoma, Centro de Investigación en Salud Mental (CIBERSAM), Madrid, Spain.
authors.forename: Maria L
authors.initials: ML
authors.lastname: Barrigon
authors.affiliation: Unidad de Salud Mental Infantil (USMI), Hospital Virgen Macarena, Sevilla, Spain.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Blanco-Morales
authors.affiliation: Unidad de Salud Mental Infantil (USMI), Hospital Virgen Macarena, Sevilla, Spain.
authors.forename: Evelio
authors.initials: E
authors.lastname: Igunza
authors.affiliation: USMI, Hospital Torrecardenas, Almeria, Spain.
authors.forename: Anselmo
authors.initials: A
authors.lastname: Cañabate
authors.affiliation: USMI, Hospital Virgen de Valme, Sevilla, Spain.
authors.forename: Maria D
authors.initials: MD
authors.lastname: Garcia
authors.affiliation: USMI, Hospital Reina Sofia, Córdoba, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Guijarro
authors.affiliation: USMI, Hospital Virgen de las Nieves, Granada, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Diaz-Atienza
authors.affiliation: Institute of Psychiatry, London, UK.
authors.forename: Maite
authors.initials: M
authors.lastname: Ferrin
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D003072:Cognition Disorders / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012737:Sex Factors