title: Dopamine and uric acid electrochemical sensor based on a glassy carbon electrode modified with cubic Pd and reduced graphene oxide nanocomposite.
abstract: A cubic Pd and reduced graphene oxide modified glassy carbon electrode (Pd/RGO/GCE) was fabricated to simultaneously detect dopamine (DA) and uric acid (UA) by cyclic voltammetry (CV) and different pulse voltammetry (DPV) methods. Compared with Pd/GCE and RGO/GCE, the Pd/RGO/GCE exhibited excellent electrochemical activity in electrocatalytic behaviors. Performing the Pd/RGO/GCE in CV measurement, the well-defined oxidation peak potentials separation between DA and UA reached to 145mV. By using the differential pulse voltammetry (DPV) technique, the calibration curves for DA and UA were found linear with the concentration range of 0.45-421μM and 6-469.5μM and the detection limit (S/N =3) were calculated to be 0.18μM and 1.6μM, respectively. Furthermore, the Pd/RGO/GCE displayed high selectivity when it was applied into the determination of DA and UA even though in presence of high concentration of interferents. Additionally, the prepared electrochemical sensor of Pd/RGO/GCE demonstrated a practical feasibility in rat urine and serum samples determination.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
authors.forename: Beibei
authors.initials: B
authors.lastname: Yang
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
authors.forename: Jiatai
authors.initials: J
authors.lastname: Zhong
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yan
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhang
authors.affiliation: School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, PR China.
authors.forename: Chunyang
authors.initials: C
authors.lastname: Zhai
authors.affiliation: Tokyo University of Science Yamaguchi, Sanyo-Onoda-shi, Yamaguchi 756-0884, Japan.
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Shiraishi
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China; Tokyo University of Science Yamaguchi, Sanyo-Onoda-shi, Yamaguchi 756-0884, Japan. Electronic address: duyk@suda.edu.cn.
authors.forename: Yukou
authors.initials: Y
authors.lastname: Du
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry*; D004298:Dopamine / Q000032:analysis* / Q000097:blood / Q000652:urine; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D007854:Lead / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D051381:Rats; D014527:Uric Acid / Q000032:analysis* / Q000097:blood / Q000652:urine
chemical_list: D010087:Oxides; D014527:Uric Acid; D007854:Lead; D002244:Carbon; D006108:Graphite; D004298:Dopamine
keywords: Dopamine; Electrochemical detection; Graphene; Pd nanocubes; Uric acid