title: [Arterial Hypertension Complicated by Myocardial Hypertrophy and Heart Failure Is Associated With Lower Serum Levels of Vascular Endothelium Growth Factor (VEGF-A165)].
abstract: OBJECTIVE
  To study relationships of serum levels of vascular endothelium growth factor with left ventricular (LV) myocardial hypertrophy (H) and signs of heart failure (HF) in patients with arterial hypertension (AH).
  
  
  METHODS
  We examined 47 patients with AH and by echo established thickening ( more or equal 16 mm) of LV wall and 47 patients with AH and normal (<12 mm) thickness of LV wall from control group selected according to "head-to-head" principle by age and sex. Serum VEGF-A165 level was measured by sandwich solid-phase immunoenzyme assay.
  
  
  RESULTS
  VEGF-A165 level was significantly lower in the group of patients with LVH compared with control group (273.3+/-41.75 vs. 426.6+/-50.00 pg/ml, =0.016). VEGF-A165 level in patients with LVH and NYHA class III HF (140.4+/-51.49 pg/ml) was highly significantly different (p <0.001) from that in in patients without LVH.
  
  
  CONCLUSIONS
  Presence of LVH and HF in patients with AH was associated with lower levels of VEGF-A165 in peripheral blood.
authors.affiliation: 1Educational Scientific Medical Centre of the General Management Department of the President of Russia, Moscow, Russia; 2Sity Clinical Hospital 17, Moscow, Russia; 3State Clinical Hospital 51, Moscow, Russia; 4Federal Research Clinical Center for specialized types of health care and medical technologies, Moscow, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Chumakova
authors.affiliation: 1Educational Scientific Medical Centre of the General Management Department of the President of Russia, Moscow, Russia; 2Sity Clinical Hospital 17, Moscow, Russia; 3State Clinical Hospital 51, Moscow, Russia; 4Federal Research Clinical Center for specialized types of health care and medical technologies, Moscow, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Tipteva
authors.affiliation: 1Educational Scientific Medical Centre of the General Management Department of the President of Russia, Moscow, Russia; 2Sity Clinical Hospital 17, Moscow, Russia; 3State Clinical Hospital 51, Moscow, Russia; 4Federal Research Clinical Center for specialized types of health care and medical technologies, Moscow, Russia.
authors.forename: N E
authors.initials: NE
authors.lastname: Resnichenko
authors.affiliation: 1Educational Scientific Medical Centre of the General Management Department of the President of Russia, Moscow, Russia; 2Sity Clinical Hospital 17, Moscow, Russia; 3State Clinical Hospital 51, Moscow, Russia; 4Federal Research Clinical Center for specialized types of health care and medical technologies, Moscow, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Zateyshchikov