title: Effects of two different lipid emulsions on morbidities and oxidant stress statuses in preterm infants: an observational study.
abstract: OBJECTIVE
  We examined the morbidities and oxidative stress statuses in preterms receiving either SMOFlipid or ClinOleic.
  
  
  METHODS
  This observational study was performed in Etlik Zubeyde Hanim Hospital, Turkey. Infants received SMOFlipid (5 months) or ClinOleic (7 months). Two hundred and twenty seven infants (SMOFlipid: 93, ClinOleic: 134) very low birth weighted infants were included. The oxidative stress status was evaluated in infants at low risk of oxidative stress by total antioxidant capacity (TAC) and total oxidant status (TOS) and oxidative stress index (OSI; TAC/TOS/100) at baseline, first week and third week.
  
  
  RESULTS
  Parenteral nutrition was given for a median of 7 days in both groups. There were statistically insignificantly higher rates of retinopathy of prematurity (9.4 versus 11.7%) and chronic lung disease (4.7 versus 6.7%) in ClinOleic group compared with SMOFlipid group. The TAC, TOS and OSI decreased significantly in ClinOleic group after 1 week, and although the results were not statistically significant, the TAC increased while the TOS and OSI decreased in SMOFlipid group. In both groups, the TAC, TOS and OSI were lower than baseline after 3 weeks.
  
  
  CONCLUSIONS
  SMOFlipid and ClinOleic result in similar oxidative stress statuses after they were stopped, and we detected no statistically significant differences in morbidity rates.
authors.affiliation: a Department of Neonatology , Etlik Zubeyde Hanım Women's Teaching and Research Hospital , Ankara , Turkey.
authors.forename: Sezin
authors.initials: S
authors.lastname: Unal
authors.affiliation: a Department of Neonatology , Etlik Zubeyde Hanım Women's Teaching and Research Hospital , Ankara , Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Demirel
authors.affiliation: a Department of Neonatology , Etlik Zubeyde Hanım Women's Teaching and Research Hospital , Ankara , Turkey.
authors.forename: Sara
authors.initials: S
authors.lastname: Erol
authors.affiliation: a Department of Neonatology , Etlik Zubeyde Hanım Women's Teaching and Research Hospital , Ankara , Turkey.
authors.forename: Dilek Ulubas
authors.initials: DU
authors.lastname: Isik
authors.affiliation: a Department of Neonatology , Etlik Zubeyde Hanım Women's Teaching and Research Hospital , Ankara , Turkey.
authors.forename: Ferit
authors.initials: F
authors.lastname: Kulali
authors.affiliation: a Department of Neonatology , Etlik Zubeyde Hanım Women's Teaching and Research Hospital , Ankara , Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Iyigun
authors.affiliation: a Department of Neonatology , Etlik Zubeyde Hanım Women's Teaching and Research Hospital , Ankara , Turkey.
authors.forename: Ahmet Yagmur
authors.initials: AY
authors.lastname: Bas
mesh_terms: D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage* / Q000009:adverse effects; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010289:Parenteral Nutrition, Total / Q000379:methods*; D010938:Plant Oils / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011446:Prospective Studies; D012178:Retinopathy of Prematurity / Q000453:epidemiology; D013024:Soybean Oil / Q000008:administration & dosage* / Q000009:adverse effects; D014421:Turkey / Q000453:epidemiology
chemical_list: C568346:ClinOleic; D005217:Fat Emulsions, Intravenous; D005395:Fish Oils; D010938:Plant Oils; D013024:Soybean Oil
keywords: Fish oil; olive oil; oxidative stress; preterm; total parenteral nutrition