title: Extensive bullous lichen sclerosus et atrophicus.
abstract: Lichen sclerosus et atrophicus is a chronic disease of unknown etiology characterized by atrophic and sclerotic plaques in both genital and extragenital regions. Extensive bullous lichen sclerosus et atrophicus (BLSA) is a severe variant of the disease with no widely accepted treatment. We present a 63-year-old woman with extensive extragenital, ivory-colored, atrophic plaques on her trunk and extremities and disseminated hemorrhagic bullae. The patient was unsuccessfully treated with standard topical corticosteroid therapy, doxycycline and chloroquine. According to the literature, there is little evidence of the efficacy of doxycycline and hydroxychloroquine in the treatment of BLSA. We report a rare case of extensive BLSA that is unresponsive to these drugs.
authors.affiliation: Clinical Center of Serbia, Faculty of Medicine, University of Belgrade - Belgrade, Serbia.
authors.forename: Jelica
authors.initials: J
authors.lastname: Vukicevic
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001706:Biopsy; D001768:Blister / Q000188:drug therapy / Q000473:pathology*; D003879:Dermatologic Agents / Q000627:therapeutic use; D020405:Dermis / Q000473:pathology; D004318:Doxycycline / Q000627:therapeutic use; D004817:Epidermis / Q000473:pathology; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D018459:Lichen Sclerosus et Atrophicus / Q000188:drug therapy / Q000473:pathology*; D008875:Middle Aged; D017211:Treatment Failure
chemical_list: D000305:Adrenal Cortex Hormones; D003879:Dermatologic Agents; D006886:Hydroxychloroquine; D004318:Doxycycline