title: Inflammatory bowel diseases: a burden in pediatrics: Case series and a review of the literature.
abstract: BACKGROUND
  Inflammatory bowel disease is a chronic condition of the gastrointestinal tract, comprising mainly Crohn disease (CD) and ulcerative colitis (UC). Both of them are frequently encountered in children, being multifactorial conditions, with an unclear etiology.
  
  
  METHODS
  We present 4 cases of inflammatory bowel disease (IBD) in children in order to underline the variable evolution depending on the patient's particularities.
  The first case, a 13-year-old male patient, with a history of Henoch-Schonlein purpura, was admitted for rectal bleeding and weight loss, with normal laboratory parameters. The colonoscopy and the histopathological examination established the diagnosis of UC. The evolution was initially favorable under corticosteroids and sulfasalazine, but with 3 relapses in 2 years. The second case, a 16-year-old male patient, with a history of lactose intolerance and constipation, was admitted for bloody, diarrheic stools, the laboratory tests pointing out only leukocytosis with neutrophilia. The colonoscopy and histopathological examination established the diagnosis of UC. The patient's evolution was slowly favorable. The third case, a 9-year old male patient, with emotional disorders and babbling, admitted for semiconsistent, bloody stools, with increased inflammatory tests, whose colonoscopy pointed out diffuse edema and hemorrhages, the histopathological examination establishing the diagnosis of CD. The evolution was initially favorable, but with 5 relapses in 3 years. The last case, a 12-year-old male patient, was admitted with diarrheic, bloody stools, refractory to antibiotics, and weight loss, with increased inflammatory tests. The colonoscopy pointed out ulcerations, hemorrhages, and disseminated puss deposits. The histopathological examination established the diagnosis of CD. The patient's evolution was favorable, with only 1 relapse in 3 years.
  
  
  CONCLUSIONS
  The adequate management, especially the self-management can influence the prognosis of patients with IBD, even though it is unpredictable and burdened by the risk of malignant transformation.
authors.affiliation: Department of Pediatrics I, University of Medicine and Pharmacy Department of Pathology, County Hospital, Tîrgu Mureş, Romania.
authors.forename: Cristina Oana
authors.initials: CO
authors.lastname: Mărginean
authors.forename: Lorena Elena
authors.initials: LE
authors.lastname: Meliţ
authors.forename: Simona
authors.initials: S
authors.lastname: Mocanu
authors.forename: Maria Oana
authors.initials: MO
authors.lastname: Mărginean
mesh_terms: D000293:Adolescent; D002648:Child; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D008297:Male