title: Genome-wide characterization of Mediator recruitment, function, and regulation.
abstract: Mediator is a conserved and essential coactivator complex broadly required for RNA polymerase II (RNAPII) transcription. Recent genome-wide studies of Mediator binding in budding yeast have revealed new insights into the functions of this critical complex and raised new questions about its role in the regulation of gene expression.
authors.affiliation: a Basic Sciences Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA.
authors.forename: Sebastian
authors.identifier: 0000-0002-5694-0574
authors.initials: S
authors.lastname: Grünberg
authors.affiliation: b Department of Biology , Indiana University , Bloomington , IN USA.
authors.forename: Gabriel E
authors.identifier: 0000-0002-0801-7646
authors.initials: GE
authors.lastname: Zentner
mesh_terms: D015966:Gene Expression Regulation, Fungal / Q000502:physiology*; D016681:Genome, Fungal / Q000502:physiology*; D056892:Mediator Complex / Q000235:genetics / Q000378:metabolism; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D056892:Mediator Complex; D029702:Schizosaccharomyces pombe Proteins; D012319:RNA Polymerase II
keywords: ChEC-seq; Mediator; Pre-initiation complex; RNA polymerase II; TFIID