title: Role of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor regulation in stress-induced pain chronification.
abstract: Persistent postsurgical pain is a serious issue in public health, which has received increased interest in recent years. Previous studies have reported that psychological factors promote the development of chronic postsurgical pain. However, it is unclear how chronification of postsurgical pain occurs. The α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPA) phosphorylation in the central nervous system plays a critical role in synaptic plasticity and contributes to central sensitization and chronic pain development. Here, we discuss the role of AMPA receptor regulation in stress-induced pain chronification after surgery.
authors.affiliation: Sufang Liu, Feng Tao, Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX 75246, United States.
authors.forename: Sufang
authors.initials: S
authors.lastname: Liu
authors.affiliation: Sufang Liu, Feng Tao, Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX 75246, United States.
authors.forename: Feng
authors.initials: F
authors.lastname: Tao
keywords: Pain chronification; Stress; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor phosphorylation