title: The substitution V379I in PA protein attenuates the pathogenicity of influenza A (H1N1) pdm09 viruses in mice.
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, 102206, China.
authors.forename: Yongkun
authors.initials: Y
authors.lastname: Chen
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, 102206, China.
authors.forename: Wenfei
authors.initials: W
authors.lastname: Zhu
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, 102206, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Bai
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, 102206, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zou
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Changsha, 410005, China.
authors.forename: Siyu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Changsha Central Hospital, Changsha, 410004, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, 102206, China.
authors.forename: Xiyan
authors.initials: X
authors.lastname: Li
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Changsha, 410005, China.
authors.forename: Xingyu
authors.initials: X
authors.lastname: Xiang
authors.affiliation: Jilin Provincial Center for Disease Control and Prevention, Changchun, 130062, China.
authors.forename: Qinglong
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Changsha, 410005, China.
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Huang
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, 102206, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, 102206, China.
authors.forename: Dayan
authors.initials: D
authors.lastname: Wang
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, 102206, China. yshu@cnic.org.cn.
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Shu
mesh_terms: D019943:Amino Acid Substitution; D000818:Animals; D002417:Cattle; D004285:Dogs; D005260:Female; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics* / Q000472:pathogenicity*; D061985:Madin Darby Canine Kidney Cells; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000821:virology*; D012324:RNA-Dependent RNA Polymerase / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics*; D014774:Virulence / Q000235:genetics; D014779:Virus Replication / Q000235:genetics
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; C061290:PA protein, influenza viruses; D014764:Viral Proteins; D012324:RNA-Dependent RNA Polymerase