title: Pancreatic Cancer Genomics 2.0: Profiling Metastases.
abstract: Pancreatic ductal adenocarcinoma, even when diagnosed early, nearly always metastasizes. Recurrent mutations and genomic instability are early events in the disease. Two recent papers advance our understanding of how the cancer genome evolves as the primary tumor migrates from its origin in the pancreas to colonize distant metastatic sites.
authors.affiliation: Helen Diller Comprehensive Cancer Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address: collissonlab@gmail.com.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Collisson
authors.affiliation: Departments of Pathology and Translational Molecular Pathology, Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: amaitra@mdanderson.org.
authors.forename: Anirban
authors.initials: A
authors.lastname: Maitra
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D021441:Carcinoma, Pancreatic Ductal; D023281:Genomics; D006801:Humans; D010179:Pancreas; D010190:Pancreatic Neoplasms / Q000175:diagnosis*