title: Level of FABP3, FABP4, Nt-proBNP and Total Cardiovascular Risk in the Population of Central Kazakhstan.
abstract: OBJECTIVE
  The study analyzed the level of cytokines playing the significant role in the diagnosis of circulatory system diseases and total cardiovascular risk.
  
  
  METHODS
  The study involved 1,244 residents of Karaganda region. We had studied baseline participant characteristics, in addition to calculating the total cardiovascular risk and assessment of Fatty Acid Binding Proteins 3 (FABP3), Fatty Acid Binding Proteins 4 (FABP4) and N-Terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP) level.
  
  
  RESULTS
  The results showed the combination of high cardiovascular risk (CVR) with increased titers of cardiac markers, reflecting common pathogenic mechanisms in its development, among residents of Karaganda region.
  
  
  CONCLUSIONS
  The combination of high CVR with the increased titers of cardiac markers showed common pathogenic mechanisms in its development, and support the diagnostic and prognostic value of these parameters among residents of Karaganda region, and also reflects the possibility to include these cardiac markers in the program of screening survey of population for early prevention of cardiovascular disease and its complications.
authors.affiliation: Karaganda State Medical University, Department of Internal Medicine 2, Karaganda, Kazakhstan.
authors.forename: Alexandr Borisovich
authors.initials: AB
authors.lastname: Marchenko
authors.affiliation: Karaganda State Medical University, Department of Internal Medicine 2, Karaganda, Kazakhstan.
authors.forename: Farida Ustarovna
authors.initials: FU
authors.lastname: Nildibayeva
authors.affiliation: Karaganda State Medical University, Department of Medical Biophysics and Informatics, Karaganda, Kazakhstan.
authors.forename: Marina Anatolevna
authors.initials: MA
authors.lastname: Sorokina
authors.affiliation: Karaganda State Medical University, Department of Internal Medicine 2, Karaganda, Kazakhstan.
authors.forename: Elena Mihaylovna
authors.initials: EM
authors.lastname: Laryushina
authors.affiliation: Karaganda State Medical University, Department of Internal Medicine 3, Karaganda, Kazakhstan.
authors.forename: Lyudmila Gennadevna
authors.initials: LG
authors.lastname: Turgunova
authors.affiliation: Karaganda State Medical University, Vice-rector for strategic development, research and international collaboration, Karaganda, Kazakhstan.
authors.forename: Anar Akyilbekovna
authors.initials: AA
authors.lastname: Turmukhambetova
keywords: Central Kazakhstan; cardiac markers; epidemiology; pathogenesis; total cardiovascular risk