title: Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution.
abstract: Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation timeT1of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ∼3. Here, we demonstrate that a remarkable increase in the propane hyperpolarization decay time at high magnetic field (7.1 T) can be achieved by its dissolution in deuterated organic solvents (acetone-d6or methanol-d4). The approximate values of the HP decay time for propane dissolved in acetone-d6are 35.1 and 28.6 s for the CH2group and the CH3group, respectively (similar values were obtained for propane dissolved in methanol-d4), which are ∼50 times larger than the gaseous propaneT1value. Furthermore, we show that it is possible to retrieve HP propane from solution to the gas phase with the preservation of hyperpolarization.
authors.affiliation: International Tomography Center SB RAS, 3A Institutskaya Street, 630090 Novosibirsk, Russia; Novosibirsk State University, 2 Pirogova Street, 630090 Novosibirsk, Russia.
authors.forename: Dudari B
authors.initials: DB
authors.lastname: Burueva
authors.affiliation: International Tomography Center SB RAS, 3A Institutskaya Street, 630090 Novosibirsk, Russia; Novosibirsk State University, 2 Pirogova Street, 630090 Novosibirsk, Russia.
authors.forename: Alexey S
authors.initials: AS
authors.lastname: Romanov
authors.affiliation: International Tomography Center SB RAS, 3A Institutskaya Street, 630090 Novosibirsk, Russia; Novosibirsk State University, 2 Pirogova Street, 630090 Novosibirsk, Russia.
authors.forename: Oleg G
authors.initials: OG
authors.lastname: Salnikov
authors.affiliation: International Tomography Center SB RAS, 3A Institutskaya Street, 630090 Novosibirsk, Russia; Novosibirsk State University, 2 Pirogova Street, 630090 Novosibirsk, Russia.
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Zhivonitko
authors.affiliation: Department of Chemistry and Biochemistry, National Chung Cheng University , 168 University Road, Min-Hsiung, Chiayi 62102, Taiwan.
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Chen
authors.affiliation: Department of Radiology, Vanderbilt University Institute of Imaging Science (VUIIS), 1161 21st Avenue South, Medical Center North, AA-1105, Nashville, Tennessee 37232-2310, United States; Department of Biomedical Engineering and Physics, Vanderbilt-Ingram Cancer Center (VICC), 1301 Medical Center Drive, Nashville, Tennessee 37232-2310, United States.
authors.forename: Danila A
authors.initials: DA
authors.lastname: Barskiy
authors.affiliation: Department of Radiology, Vanderbilt University Institute of Imaging Science (VUIIS), 1161 21st Avenue South, Medical Center North, AA-1105, Nashville, Tennessee 37232-2310, United States; Department of Biomedical Engineering and Physics, Vanderbilt-Ingram Cancer Center (VICC), 1301 Medical Center Drive, Nashville, Tennessee 37232-2310, United States; Russian Academy of Sciences, 14 Leninskiy Prospekt, 119991 Moscow, Russia.
authors.forename: Eduard Y
authors.initials: EY
authors.lastname: Chekmenev
authors.affiliation: Department of Chemistry and Biochemistry, National Chung Cheng University , 168 University Road, Min-Hsiung, Chiayi 62102, Taiwan.
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Hwang
authors.affiliation: International Tomography Center SB RAS, 3A Institutskaya Street, 630090 Novosibirsk, Russia; Novosibirsk State University, 2 Pirogova Street, 630090 Novosibirsk, Russia.
authors.forename: Kirill V
authors.initials: KV
authors.lastname: Kovtunov
authors.affiliation: International Tomography Center SB RAS, 3A Institutskaya Street, 630090 Novosibirsk, Russia; Novosibirsk State University, 2 Pirogova Street, 630090 Novosibirsk, Russia.
authors.forename: Igor V
authors.initials: IV
authors.lastname: Koptyug