title: Influence of Synbiotics on Selected Oxidative Stress Parameters.
abstract: The aim of the present study was to assess synbiotic (Lactobacillus casei+ inulin) influence on oxidative stress parameters such as concentrations of malondialdehyde (MDA), hydrogen peroxide (H2O2), glutathione, and free sulfhydryl groups content. Experiments were carried out on healthy volunteers (n= 32). The subjects were divided into women group (n= 16) and men group (n= 16) and randomly assigned to synbiotic and control groups. Blood samples were collected before synbiotic supplementation and after 7 wks, at the end of the study. The administration of synbiotic resulted in a significant decrease in MDA (p< 0.01), H2O2(p< 0.01), and GSSG concentrations (p< 0.05) as compared with the control groups and significant increase in the concentrations of GSHt (p< 0.001), GSH (p< 0.01), and -SH group content (p< 0.05) versus control. Synbiotics containingL. caseiplus inulin may have positive influence on selected oxidative stress markers.
authors.affiliation: Department of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, 7/9 Zeligowskiego St, 90-752 Lodz, Poland.
authors.forename: Paulina
authors.identifier: 0000-0001-5867-6239
authors.initials: P
authors.lastname: Kleniewska
authors.affiliation: Department of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, 7/9 Zeligowskiego St, 90-752 Lodz, Poland.
authors.forename: Rafał
authors.identifier: 0000-0001-6784-453X
authors.initials: R
authors.lastname: Pawliczak
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005978:Glutathione / Q000097:blood; D064368:Healthy Volunteers; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D007444:Inulin / Q000008:administration & dosage* / Q000378:metabolism; D007780:Lacticaseibacillus casei / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D011044:Poland; D013438:Sulfhydryl Compounds / Q000097:blood; D058616:Synbiotics / Q000008:administration & dosage*; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D013438:Sulfhydryl Compounds; D008315:Malondialdehyde; D007444:Inulin; D006861:Hydrogen Peroxide; D005978:Glutathione