title: Cytotoxic Natural Products from Marine Sponge-Derived Microorganisms.
abstract: A growing body of evidence indicates that marine sponge-derived microbes possess the potential ability to make prolific natural products with therapeutic effects. This review for the first time provides a comprehensive overview of new cytotoxic agents from these marine microbes over the last 62 years from 1955 to 2016, which are assorted into seven types: terpenes, alkaloids, peptides, aromatics, lactones, steroids, and miscellaneous compounds.
authors.affiliation: School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China. hwzhang@zjut.edu.cn.
authors.forename: Huawei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China. baixl2012@163.com.
authors.forename: Ziping
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China. yingzhoudengyuan@sina.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000378:metabolism*; D001688:Biological Products / Q000494:pharmacology*; D006801:Humans; D010455:Peptides / Q000494:pharmacology; D011161:Porifera / Q000378:metabolism*; D013256:Steroids / Q000494:pharmacology
chemical_list: D001688:Biological Products; D010455:Peptides; D013256:Steroids
keywords: cytotoxic compound; marine microbe; natural product; sponge-derived microbe