title: Endothelin 1 as a predictor marker for bronchopulmonary dysplasia in preterm neonates with respiratory distress syndrome.
abstract: OBJECTIVE
  We aimed to investigate if endothelin 1 concentration at day 3 postnatal age could be used as a predictive marker for development of bronchopulmonary dysplasia in preterm neonates with respiratory distress syndrome.
  
  
  METHODS
  This prospective observational study was done on 69 preterm neonates with gestational ages between 28 and 34 weeks and diagnosed as having respiratory distress syndrome. Serum concentrations of endothelin 1 was measured for all patients at day 3 of life and they were divided into BPD and No-BPD groups according to whether they developed bronchopulmonary dysplasia or not.
  
  
  RESULTS
  A total of 17 infants were in the BPD group and 52 infants were in the No-BPD group. Serum endothelin 1 was significantly higher in the BPD group (435.39±172.88) compared with the No-BPD group (302.65±49.32) (p < 0.001). Serum endothelin 1 correlated significantly with days spent on mechanical ventilation (r = 0.379, p = 0.022) and days spent on CPAP (r = 0.391, p = 0.001). A serum endothelin 1 cut off value of 302.7 ng/L could predict preterm that will develop bronchopulmonary dysplasia with a sensitivity of 88.24%, and specificity of 61.54%.
  
  
  CONCLUSIONS
  Serum endothelin 1 is significantly increased at day 3 of life in preterm neonates with respiratory distress syndrome who later develop bronchopulmonary dysplasia (BPD). It seems to be a promising predictive marker for BPD but further studies are needed to find the appropriate time for its measurement.
authors.affiliation: Departments of Pediatric and Neonatology, Ain Shams University, Cairo, Egypt.
authors.forename: M S
authors.initials: MS
authors.lastname: El Shemi
authors.affiliation: Military Medical Academy, Cairo, Egypt.
authors.forename: S
authors.initials: S
authors.lastname: Tawfik
authors.affiliation: Departments of Pediatric and Neonatology, Ain Shams University, Cairo, Egypt.
authors.forename: S M
authors.initials: SM
authors.lastname: Khafagy
authors.affiliation: Department of Clinical Pathology, Ain Shams University, Cairo, Egypt.
authors.forename: M T
authors.initials: MT
authors.lastname: Hamza
authors.affiliation: Departments of Pediatric and Neonatology, Ain Shams University, Cairo, Egypt.
authors.forename: A M A
authors.initials: AM
authors.lastname: Youssef
mesh_terms: D015415:Biomarkers / Q000097:blood; D001997:Bronchopulmonary Dysplasia / Q000097:blood* / Q000453:epidemiology; D003661:Decision Support Techniques; D019332:Endothelin-1 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011446:Prospective Studies; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D019332:Endothelin-1
keywords: Bronchopulmonary dysplasia; endothelin 1; preterm; respiratory distress syndrome