title: Evaluation of New Biphasic Calcium Phosphate Bone Substitute: Rabbit Femur Defect Model and Preliminary Clinical Results.
abstract: Autogenous bone grafting, used to repair bone defects, is limited and the donor site can experience complications. Compared to autogenous bone graft, artificial bones have different porosity, which might make them suitable alternatives to bone grafts. Here, two porous biphasic calcium phosphate bone substitutes, namely Bicera™ and Triosite™, are used in an animal study and clinical practice to find a suitable porosity for implantation. Bicera™ and Triosite™ consist of 60 wt% hydroxyapatite and 40 wt% β-tricalcium phosphate, with the porosity of Bicera™ (82%) being higher than that of Triosite™ (70%). In the animal study, the implantation procedure was carried out on twenty-four female New Zealand rabbits. 12 weeks after implantation, the new bones were well infiltrated into the Bicera™ and Triosite™ bone grafts. In the clinical study, patients with comminuted fracture, fracture nonunion, or arthrodesis were included in the study of bone substitution with Bicera™. 27 patients underwent fracture fixation treatment. Bone healing of 22.22% (6/27) of patients happened within 3 months after the surgery, and that of 66.67% (18/27) of patients happened within 6 months. These results reveal that Bicera™ has good incorporation with host bone, and that new bone is able to grow within the porous structure, giving it high potential in the treatment of bone defects.
authors.affiliation: Department of Orthopaedic Surgery, Far Eastern Memorial Hospital, Banqiao, 21 Nanya S. Rd. Sec. 2, Banciao Dist., New Taipei City, 220 Taiwan.|Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, 10002 Taiwan.
authors.forename: Yeong-Jang
authors.initials: YJ
authors.lastname: Chen
authors.affiliation: Department of Orthopaedic Surgery, Far Eastern Memorial Hospital, Banqiao, 21 Nanya S. Rd. Sec. 2, Banciao Dist., New Taipei City, 220 Taiwan.|Institute of Biomedical Engineering, National Taiwan University, Taipei, 10002 Taiwan.
authors.forename: Jwo-Luen
authors.initials: JL
authors.lastname: Pao
authors.affiliation: Department of Orthopaedic Surgery, Far Eastern Memorial Hospital, Banqiao, 21 Nanya S. Rd. Sec. 2, Banciao Dist., New Taipei City, 220 Taiwan.|Institute of Biomedical Engineering, National Taiwan University, Taipei, 10002 Taiwan.
authors.forename: Chiang Sang
authors.initials: CS
authors.lastname: Chen
authors.affiliation: Department of Orthopaedic Surgery, Far Eastern Memorial Hospital, Banqiao, 21 Nanya S. Rd. Sec. 2, Banciao Dist., New Taipei City, 220 Taiwan.|Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, 32003 Taiwan.
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Department of Orthopaedic Surgery, Far Eastern Memorial Hospital, Banqiao, 21 Nanya S. Rd. Sec. 2, Banciao Dist., New Taipei City, 220 Taiwan.
authors.forename: Chun-Chien
authors.initials: CC
authors.lastname: Chang
authors.affiliation: Department of Surgical Intensive Care Unit, Far Eastern Memorial Hospital, New Taipei City, 220 Taiwan.
authors.forename: Fang-Ming
authors.initials: FM
authors.lastname: Hung
authors.affiliation: Department of Orthopaedic Surgery, Far Eastern Memorial Hospital, Banqiao, 21 Nanya S. Rd. Sec. 2, Banciao Dist., New Taipei City, 220 Taiwan.|Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, 32003 Taiwan.
authors.forename: Chih-Hung
authors.initials: CH
authors.lastname: Chang
keywords: Biphasic calcium phosphate; Bone substitute; Fracture healing; Hydroxyapatite