title: Leptin and adiponectin levels in discordant dichorionic twins at 72 hours of age-associations with anthropometric parameters and insulin resistance.
abstract: BACKGROUND
  Insulin resistance (IR) in adults has been associated with intrauterine growth restriction (IUGR). Leptin and adiponectin correlations with anthropometric parameters and IR at 72 h in discordant twins were tested.
  
  
  METHODS
  We included 24 discordant (birth weight discordance ≥20% in relation to the heavier cotwin) and 30 concordant (birth weight discordance ≤10%) twins.
  
  
  RESULTS
  A correlation between leptin (but not adiponectin) level and birth weight (BW), birth length and head circumference in IUGR twins was recorded (p<0.05). Insulin sensitivity (IS) and homeostatic model assessment (HOMA)-IR in IUGR twins were similar to appropriate-for-gestational-age cotwins and unrelated to adipokines. In IUGR twins, adiponectin and insulin associated positively. In larger concordant twins' leptin level correlated with HOMA-IR and insulin.
  
  
  CONCLUSIONS
  Leptin, but not adiponectin, levels correlate positively with anthropometric parameters in IUGR twins. IR in IUGR twins is unrelated to adipokines in the first few days of life.
authors.affiliation: Clinic for Gynecology and Obstetrics, Clinical Center of Serbia - Neonatology, Višegradska 26, Belgrade 11000.
authors.forename: Svetlana J
authors.initials: SJ
authors.lastname: Milenković
authors.affiliation: Clinic for Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade.
authors.forename: Ljiljana B
authors.initials: LB
authors.lastname: Mirković
authors.affiliation: Clinic for Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade.
authors.forename: Miljana Z
authors.initials: MZ
authors.lastname: Jovandarić
authors.affiliation: Center for Anesthesia and Resuscitation, Clinical Center of Serbia, Belgrade.
authors.forename: Dušan M
authors.initials: DM
authors.lastname: Milenković
authors.affiliation: Clinic for Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade.
authors.forename: Violeta V
authors.initials: VV
authors.lastname: Banković
authors.affiliation: School of Medicine, University of Belgrade, Belgrade.
authors.forename: Borisav Z
authors.initials: BZ
authors.lastname: Janković
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000367:Age Factors; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000503:physiopathology; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D013997:Time Factors; D014429:Twins, Dizygotic
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin
keywords: adiponectin; fetal programming; insulin sensitivity (IS); intrauterine growth restriction (IUGR); leptin; twins