title: Platelet Count and Mean Platelet Volume at the Time of and After Acute Myocardial Infarction.
abstract: Platelet count has been shown to be lower and mean platelet volume (MPV) to be higher in acute myocardial infarction (MI). However, it is not known whether these changes persist post-MI or if these measures are able to distinguish between acute thrombotic and non-thrombotic MI. Platelet count and MPV were measured in 80 subjects with acute MI (thrombotic and non-thrombotic) and stable coronary artery disease (CAD) at cardiac catheterization (acute phase) and at >3-month follow-up (quiescent phase). Subjects were stratified using stringent clinical, biochemical, histological, and angiographic criteria. Outcome measures were compared between groups by analysis of variance. Forty-seven subjects met criteria for acute MI with clearly defined thrombotic (n = 22) and non-thrombotic (n = 12) subsets. Fourteen subjects met criteria for stable CAD. No significant difference was observed in platelet count between subjects with acute MI and stable CAD at the acute or quiescent phase. MPV was higher in acute MI (9.18 ± 1.21) compared to stable CAD (8.13 ± 0.66; P = 0.003) at the acute phase but not at the quiescent phase (8.48 ± 0.58 vs 8.94 ± 1.42; P = 0.19). No difference in platelet count or MPV was detected between thrombotic and non-thrombotic subsets at acute or quiescent phases. The power to detect differences in these measures between thrombotic and non-thrombotic subsets was 58%. Higher MPV at the time of acute MI is not observed by 3 months post-MI (quiescent phase). Platelet count and MPV do not differ in subjects with thrombotic versus non-thrombotic MI. Further investigation is warranted to evaluate the utility of these measures in the diagnosis of acute MI.
authors.affiliation: 1 Division of Cardiovascular Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: Alok Ravindra
authors.initials: AR
authors.lastname: Amraotkar
authors.affiliation: 2 School of Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: David Day
authors.initials: DD
authors.lastname: Song
authors.affiliation: 3 Bronx Program, Icahn School of Medicine at Mount Sinai, Bronx, NY, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Otero
authors.affiliation: 1 Division of Cardiovascular Medicine, University of Louisville, Louisville, KY, USA.|4 Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA.
authors.forename: Patrick James
authors.initials: PJ
authors.lastname: Trainor
authors.affiliation: 5 Department of Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
authors.forename: Imtiaz
authors.initials: I
authors.lastname: Ismail
authors.affiliation: 6 Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
authors.forename: Vallari
authors.initials: V
authors.lastname: Kothari
authors.affiliation: 2 School of Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: Ayesha
authors.initials: A
authors.lastname: Singh
authors.affiliation: 1 Division of Cardiovascular Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Moore
authors.affiliation: 5 Department of Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.|7 Biostatistics Shared Facility, J. G. Brown Cancer Center, University of Louisville, Louisville, KY, USA.
authors.forename: Shesh Nath
authors.initials: SN
authors.lastname: Rai
authors.affiliation: 1 Division of Cardiovascular Medicine, University of Louisville, Louisville, KY, USA.|8 KentuckyOne Health Jewish Hospital, Louisville, KY, USA.|9 Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Andrew Paul
authors.initials: AP
authors.lastname: DeFilippis
mesh_terms: D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000628:therapy; D010976:Platelet Count
keywords: acute coronary syndrome; atherothrombosis; platelet activation; vascular physiology