title: Molecular mechanisms of tumour invasion: regulation by calcium signals.
abstract: Intracellular calcium (Ca2+) signals are key regulators of multiple cellular functions, both healthy and physiopathological. It is therefore unsurprising that several cancers present a strong Ca2+homeostasis deregulation. Among the various hallmarks of cancer disease, a particular role is played by metastasis, which has a critical impact on cancer patients' outcome. Importantly, Ca2+signalling has been reported to control multiple aspects of the adaptive metastatic cancer cell behaviour, including epithelial-mesenchymal transition, cell migration, local invasion and induction of angiogenesis (see Abstract Figure). In this context Ca2+signalling is considered to be a substantial intracellular tool that regulates the dynamicity and complexity of the metastatic cascade. In the present study we review the spatial and temporal organization of Ca2+fluxes, as well as the molecular mechanisms involved in metastasis, analysing the key steps which regulate initial tumour spread.
authors.affiliation: Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Equipe Labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, University of Lille, 59656, Villeneuve d'Ascq, France.
authors.forename: Oksana
authors.identifier: 0000-0002-1984-0013
authors.initials: O
authors.lastname: Iamshanova
authors.affiliation: Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Equipe Labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, University of Lille, 59656, Villeneuve d'Ascq, France.|Department of Life Science and Systems Biology, University of Torino, Torino, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Fiorio Pla
authors.affiliation: Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Equipe Labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, University of Lille, 59656, Villeneuve d'Ascq, France.
authors.forename: Natalia
authors.initials: N
authors.lastname: Prevarskaya
mesh_terms: D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D002465:Cell Movement; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D009361:Neoplasm Invasiveness
chemical_list: D002118:Calcium
keywords: calcium channel; calcium signalling; cancer cells