title: The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease.
abstract: The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer's disease has focused attention on the role this receptor family plays in the CNS. Surprisingly, it was discovered that two LDLR family members, ApoE receptor 2 (Apoer2) and VLDL receptor (Vldlr), play key roles in brain development and adult synaptic plasticity, primarily by mediating Reelin signaling. This review focuses on Apoer2 and Vldlr signaling in the CNS and its role in human disease.
authors.affiliation: Departments of Molecular Genetics and Neuroscience and Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390.
authors.forename: Courtney
authors.initials: C
authors.lastname: Lane-Donovan
authors.affiliation: Departments of Molecular Genetics and Neuroscience and Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 Joachim.herz@utsouthwestern.edu.|Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
authors.forename: Joachim
authors.initials: J
authors.lastname: Herz
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D002490:Central Nervous System / Q000378:metabolism* / Q000473:pathology / Q000502:physiology / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011973:Receptors, LDL / Q000737:chemistry / Q000378:metabolism*; D000091042:Reelin Protein; D015398:Signal Transduction
chemical_list: D026503:Low Density Lipoprotein Receptor-Related Protein-1; D011973:Receptors, LDL; D000091042:Reelin Protein; C036053:VLDL receptor; C000717127:RELN protein, human
keywords: Alzheimer’s disease; apolipoprotein E; apolipoprotein E receptor 2; apolipoproteins; cell signaling; endocytosis; lipoprotein receptors; neurons; very low density lipoprotein receptor