title: Investigation of the role of α-lipoic acid on fatty acids profile, some minerals (zinc, copper, iron) and antioxidant activity against aluminum-induced oxidative stress in the liver of male rats.
abstract: BACKGROUND
  We have investigated the effects of α-lipoic acid (LA), a powerful antioxidant, on the fatty acid (FA) profiles, aluminum accumulation, antioxidant activity and some minerals such as zinc, copper and iron against aluminum chloride (AlCl3)-induced oxidative stress in rat liver.
  
  
  METHODS
  Twenty-eight male Wistar rats were divided into four groups as control, LA, AlCl3 and LA+AlCl3. For 30 days, LA was intraperitoneally administrated (50 mg/kg) and AlCl3 was given via orogastric gavage (1600 ppm) every other day.
  
  
  RESULTS
  AlCl3-treated animals exhibited higher hepatic malondialdehyde concentration and lower glutathione peroxidase and catalase activity, whereas these alterations were restored by the LA supplementation. Total saturated FA of the AlCl3-treated group was higher than the LA supplementation groups. Moreover, total unsaturated FA level of the LA+AlCl3 group was higher than the AlCl3-treated group. Hepatic zinc level of the AlCl3-treated group was lower than the control group, whereas it was higher in the LA and the LA+AlCl3 groups. Hepatic copper levels did not significantly change in the experimental groups. Iron level was lower in the LA and LA+AlCl3 groups compared with the AlCl3-treated group. Moreover, the liver Al concentration was found to be lower in the LA and LA+AlCl3 groups compared to the AlCl3 group.
  
  
  CONCLUSIONS
  These results indicate that AlCl3 treatment can induce oxidative stress in the liver. LA supplementation has a beneficial effect on the AlCl3-induced alterations such as high lipid peroxidation, Al accumulation, FA profile ratios and mineral concentrations.
authors.affiliation: .
authors.forename: Zafer
authors.identifier: http://orcid.org/0000-0001-7982-7155
authors.initials: Z
authors.lastname: Sahin
authors.affiliation: .
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozkaya
authors.affiliation: .
authors.forename: Okkes
authors.initials: O
authors.lastname: Yilmaz
authors.affiliation: .
authors.forename: Abdurrauf
authors.initials: A
authors.lastname: Yuce
authors.affiliation: .
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gunes
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D002712:Chlorides / Q000494:pharmacology*; D003300:Copper / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008903:Minerals / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D008063:Thioctic Acid / Q000494:pharmacology*; D015032:Zinc / Q000378:metabolism
chemical_list: D017607:Aluminum Compounds; D000975:Antioxidants; D002712:Chlorides; D005227:Fatty Acids; D008903:Minerals; D000077410:Aluminum Chloride; D008315:Malondialdehyde; D008063:Thioctic Acid; D003300:Copper; D007501:Iron; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D015032:Zinc
keywords: aluminum; fatty acids; iron; liver; oxidative stress; zinc; α-lipoic acid