title: Orchestration of dual cyclization processes and dual quenching mechanisms for enhanced selectivity and drastic fluorescence turn-on detection of cysteine.
abstract: We reported a new approach to achieve enhanced selectivity with a drastic turn-on fluorescence response for the detection of Cys through dual intramolecular cyclization processes and dual PET and ICT quenching mechanisms by the incorporation of an acrylate and a maleimide group onto two opposite sides of a single coumarin fluorophore.
authors.affiliation: Shanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China. kylou@ecust.edu.cn.
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Tong
authors.affiliation: Shanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China. kylou@ecust.edu.cn.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Shanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China. kylou@ecust.edu.cn.
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China. kylou@ecust.edu.cn.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China. kylou@ecust.edu.cn.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Ma
authors.affiliation: Shanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China. kylou@ecust.edu.cn.
authors.forename: Kaiyan
authors.identifier: http://orcid.org/0000-0003-1231-8801
authors.initials: K
authors.lastname: Lou
authors.affiliation: Shanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China. kylou@ecust.edu.cn and Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131-0001, USA. wwang@unm.edu.
authors.forename: Wei
authors.identifier: http://orcid.org/0000-0001-6043-0860
authors.initials: W
authors.lastname: Wang