title: Audio-visual speech perception in adult readers with dyslexia: an fMRI study.
abstract: Developmental dyslexia is a specific deficit in reading and spelling that often persists into adulthood. In the present study, we used slow event-related fMRI and independent component analysis to identify brain networks involved in perception of audio-visual speech in a group of adult readers with dyslexia (RD) and a group of fluent readers (FR). Participants saw a video of a female speaker saying a disyllabic word. In the congruent condition, audio and video input were identical whereas in the incongruent condition, the two inputs differed. Participants had to respond to occasionally occurring animal names. The independent components analysis (ICA) identified several components that were differently modulated in FR and RD. Two of these components including fusiform gyrus and occipital gyrus showed less activation in RD compared to FR possibly indicating a deficit to extract face information that is needed to integrate auditory and visual information in natural speech perception. A further component centered on the superior temporal sulcus (STS) also exhibited less activation in RD compared to FR. This finding is corroborated in the univariate analysis that shows less activation in STS for RD compared to FR. These findings suggest a general impairment in recruitment of audiovisual processing areas in dyslexia during the perception of natural speech.
authors.affiliation: Department of Psychology, Otto-Friedrich University Bamberg, Bamberg, Germany.
authors.forename: Jascha
authors.initials: J
authors.lastname: Rüsseler
authors.affiliation: Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Klinikum Magdeburg, Neurologie, Magdeburg, Germany.
authors.forename: Ivonne
authors.initials: I
authors.lastname: Gerth
authors.affiliation: Department of Psychiatry, Medical School Hannover, Hannover, Germany.
authors.forename: Gregor R
authors.initials: GR
authors.lastname: Szycik
authors.affiliation: Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany. thomas.muente@neuro.uni-luebeck.de.|Institute of Psychology II, University of Lübeck, Lübeck, Germany. thomas.muente@neuro.uni-luebeck.de.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Münte
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D004410:Dyslexia / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009039:Motion Perception / Q000502:physiology*; D012938:Social Perception; D013067:Speech Perception / Q000502:physiology*; D055815:Young Adult
keywords: Audio-visual processing; Developmental dyslexia; Event-related fMRI; Independent component analysis