title: IL-17 and IL-22 in immunity: Driving protection and pathology.
abstract: IL-17 and IL-22 are tissue-signaling cytokines that favor protection and regeneration of barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share cellular sources, signaling pathways, and functional aspects; however, taking a closer look they differ, e.g. in their pro-inflammatory or regenerative potential. An imbalance of the carefully orchestrated tissue-signaling system might result in autoimmune diseases, promote cancer growth, or predispose to infectious diseases. This review highlights recent understandings in cellular sources, signaling mechanisms, physiologic as well as pathogenic role of the double-faceted cytokines IL-17 and IL-22.
authors.affiliation: Department of Dermatology and Allergy, Technische Universität Munich, Munich, Germany.
authors.forename: Kilian
authors.initials: K
authors.lastname: Eyerich
authors.affiliation: UOC Coordinamento Scientifico, Istituto Nazionale per la Promozione della Salute delle Popolazioni Migranti e il contrasto delle Malattie della Povertà, INMP, Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Dimartino
authors.affiliation: UOC Coordinamento Scientifico, Istituto Nazionale per la Promozione della Salute delle Popolazioni Migranti e il contrasto delle Malattie della Povertà, INMP, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Cavani
mesh_terms: D000818:Animals; D015551:Autoimmunity; D006801:Humans; D007109:Immunity; D007239:Infections / Q000276:immunology*; D020381:Interleukin-17 / Q000276:immunology*; D007378:Interleukins / Q000276:immunology*; D007422:Intestines / Q000276:immunology*; D008168:Lung / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D012038:Regeneration; D015398:Signal Transduction; D012867:Skin / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*; D000097043:Interleukin-22
chemical_list: D020381:Interleukin-17; D007378:Interleukins; D000097043:Interleukin-22
keywords: Th17; Th22; autoimmune diseases; cytokines