title: [Possible Relation Between Antenatal Venlafaxine Use and VACTERL Association in a Newborn: A Case Report].
abstract: Major depressive disorder is common during antenatal period and many women are prescribed antidepressant drugs despite no antidepressant can be regarded as definitely safe in pregnancy. Previous studies have suggested links between gestational use of selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI) and certain birth defects. VACTERL association is a rare group of congenital malformations which were observed to occur together more often than would be expected by chance. Diagnosis requires coexistence of at least three congenital malformations from vertebral (V), anal (A), cardiac (C), tracheoesophageal (TE), renal (R), and limb (L) regions. Here, a case of a newborn female whose mother's gestational history revealed venlafaxine use before and during her pregnancy is reported. This newborn had anal atresia, patent ductus arteriosus, tracheoesophageal fistula, and upper limb anomalies. To the best of authors' knowledge this is the first report of VACTERL association possibly related to gestational use of SSRI or SNRI.
authors.forename: Muammer Özgür
authors.initials: MÖ
authors.lastname: Çevik
authors.forename: Mustafa
authors.initials: M
authors.lastname: Çelik
authors.forename: İbrahim Hakan
authors.initials: İH
authors.lastname: Bucak
authors.forename: Behice
authors.initials: B
authors.lastname: Han Almış
authors.forename: Mehmet
authors.initials: M
authors.lastname: Turğut
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000002:abnormalities* / Q000000981:diagnostic imaging; D000928:Antidepressive Agents / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy; D003937:Diagnosis, Differential; D004947:Esophagus / Q000002:abnormalities* / Q000000981:diagnostic imaging; D017809:Fatal Outcome; D005260:Female; D006330:Heart Defects, Congenital / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities* / Q000000981:diagnostic imaging; D017880:Limb Deformities, Congenital / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D013131:Spine / Q000002:abnormalities* / Q000000981:diagnostic imaging; D014132:Trachea / Q000002:abnormalities* / Q000000981:diagnostic imaging; D000069470:Venlafaxine Hydrochloride / Q000009:adverse effects*
chemical_list: D000928:Antidepressive Agents; D000069470:Venlafaxine Hydrochloride