title: Esophagectomy for cancer in octogenarians: should we do it?
abstract: OBJECTIVE
  Inconsistent data exists regarding esophagectomy outcomes in octogenarians undergoing transhiatal esophagectomy for esophageal cancer.
  
  
  METHODS
  A retrospective review was performed for esophagectomy cancer patients between 2000 and 2012 at our tertiary referral center. Outcome data for octogenarians was compared to younger patients aged 20 to 79 years. A case-matched group of patients younger than 80 years old (n = 33) was included based on the Charlson comorbidity index with the octogenarian group (n = 33). Endpoints included operative morbidity and mortality as well as short- and long-term survival.
  
  
  RESULTS
  Thirty-three octogenarians met inclusion criteria. The median age was 82 years, and 79% were male; 76% had adenocarcinoma, 87% had distal esophageal, and 52% had poorly differentiated tumors. Stages 0 through III were observed in 6, 18, 27, and 48% of octogenarians, respectively. Neoadjuvant therapy was administered to 70% of patients, with 48% experiencing downstaging. Transhiatal esophagectomy was performed in 82% of patients, with R0 resection in 94%. The mean hospital stay was 18 days, with morbidity and mortality rates 56 and 9%, respectively, not significantly different from 13-day hospital stay, 45% morbidity, and 9% mortality in younger patients. Cardiac, pulmonary, and surgical site complications occurred in 24, 27, and 6% of octogenarians, respectively. Anastomotic leak occurred in 18% and reoperations in 3%. The median, 3-year survival, and 5-year survival were 21 months, 55.9%, and 37.1%, respectively. Overall survival was worse for octogenarians (p < 0.001).
  
  
  CONCLUSIONS
  Postoperative mortality, morbidity, and length of stay in octogenarians are comparable to younger patients, while the overall survival is worse. With appropriate patient selection, good outcomes can be accomplished in octogenarians undergoing esophagectomy for cancer.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Miami-Miller School of Medicine, 1120 NW 14th Street, CRB (C232), Miami, FL, 33136, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Paulus
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Miami-Miller School of Medicine, 1120 NW 14th Street, CRB (C232), Miami, FL, 33136, USA.
authors.forename: Caroline
authors.initials: C
authors.lastname: Ripat
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Miami-Miller School of Medicine, 1120 NW 14th Street, CRB (C232), Miami, FL, 33136, USA.
authors.forename: Vadim
authors.initials: V
authors.lastname: Koshenkov
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Miami-Miller School of Medicine, 1120 NW 14th Street, CRB (C232), Miami, FL, 33136, USA.
authors.forename: Angela T
authors.initials: AT
authors.lastname: Prescott
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Miami-Miller School of Medicine, 1120 NW 14th Street, CRB (C232), Miami, FL, 33136, USA.
authors.forename: Kiran
authors.initials: K
authors.lastname: Sethi
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Miami-Miller School of Medicine, 1120 NW 14th Street, CRB (C232), Miami, FL, 33136, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Stuart
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Miami-Miller School of Medicine, 1120 NW 14th Street, CRB (C232), Miami, FL, 33136, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Tiesi
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Miami-Miller School of Medicine, 1120 NW 14th Street, CRB (C232), Miami, FL, 33136, USA.
authors.forename: Alan S
authors.initials: AS
authors.lastname: Livingstone
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Miami-Miller School of Medicine, 1120 NW 14th Street, CRB (C232), Miami, FL, 33136, USA. dyakoub@med.miami.edu.
authors.forename: Danny
authors.initials: D
authors.lastname: Yakoub
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018579:Patient Selection; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
keywords: Elderly; Esophageal cancer; Esophagectomy; Octogenarian; Surgery