title: A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells.
abstract: A lysosome targetable naphthalimide based fluorescent probe (LyNC) has been designed and synthesized which detects hydrogen peroxide (H2O2) with high selectivity and sensitivity in brain tissues and in living nematodes among various ROS/RNS tested. Further, the probe LyNC was successfully employed in exogenous and endogenous imaging of H2O2in living cell lines.
authors.affiliation: Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India. mksharmaa@yahoo.co.in.
authors.forename: Shahi Imam
authors.initials: SI
authors.lastname: Reja
authors.affiliation: Department of Biotechnology, Guru Nanak Dev University, Amritsar, Punjab, India.
authors.forename: Muskan
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India. mksharmaa@yahoo.co.in.
authors.forename: Neha
authors.initials: N
authors.lastname: Gupta
authors.affiliation: Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India. mksharmaa@yahoo.co.in.
authors.forename: Vandana
authors.identifier: http://orcid.org/0000-0002-8740-1928
authors.initials: V
authors.lastname: Bhalla
authors.affiliation: Department of Zoology, Guru Nanak Dev University, India.
authors.forename: Puja
authors.initials: P
authors.lastname: Ohri
authors.affiliation: Department of Biotechnology, Guru Nanak Dev University, Amritsar, Punjab, India.
authors.forename: Gurcharan
authors.initials: G
authors.lastname: Kaur
authors.affiliation: Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India. mksharmaa@yahoo.co.in.
authors.forename: Manoj
authors.initials: M
authors.lastname: Kumar
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D005910:Glioma / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000032:analysis*; D008247:Lysosomes / Q000737:chemistry*; D015394:Molecular Structure; D053644:Naphthalimides / Q000138:chemical synthesis / Q000737:chemistry*; D061848:Optical Imaging / Q000379:methods*; D051381:Rats
chemical_list: D005456:Fluorescent Dyes; D053644:Naphthalimides; D006861:Hydrogen Peroxide