title: Primordium specific requirement of the homeotic gene fork head in the developing gut of the Drosophila embryo.
abstract: The homeotic gene fork head (fkh) of Drosophila melanogaster promotes terminal as opposed to segmental development in the ectodermal parts of the gut. Molecular analysis revealed that fkh expression is not restricted to the ectodermal parts of the gut, but is detectable in a variety of other tissues. Therefore, the phenotype of fkh mutant embryos was re-examined using molecular probes as tissue specific markers. With the exception of the nervous system, which was not studied, phenotypic effects were found in all tissues expressing fkh protein in the wild-type. Particularly, these tissues include all components of the gut in the Drosophila embryo: the foregut and hindgut, the midgut and the yolk nuclei. The defects observed in the gut of fkh mutant embryos are primordium specific.
authors.affiliation: Institut für Genetik und Mikrobiologie, Universität München, Maria-Ward-Straß e la, D-8000, München 19, Germany.
authors.forename: Detlef
authors.initials: D
authors.lastname: Weigel
authors.affiliation: Biozentrum der Universität, Klingelbergstraße 70, CH-4056, Basel, Switzerland.|Department of Genetics, Baylor College of Medicine, Texas Medical Center, 77030, Houston, TX, USA.
authors.forename: Hugo J
authors.initials: HJ
authors.lastname: Bellen
authors.affiliation: Institut für Genetik und Mikrobiologie, Universität München, Maria-Ward-Straß e la, D-8000, München 19, Germany.
authors.forename: Gerd
authors.initials: G
authors.lastname: Jürgens
authors.affiliation: Institut für Genetik und Mikrobiologie, Universität München, Maria-Ward-Straß e la, D-8000, München 19, Germany.
authors.forename: Herbert
authors.initials: H
authors.lastname: Jäckle
keywords: Drosophila embryo; Enhancer detection; Fork head gene; Gut development; Homeotic genes