title: A "win-win" nanoplatform: TiO2:Yb,Ho,F for NIR light-induced synergistic therapy and imaging.
abstract: To avoid the defect of low energy transfer efficiency in core-shell UCNP-TiO2NPs, doping rare earth into TiO2and improving the photocatalytic activity of TiO2itself under Vis-NIR light might be a more direct and efficient strategy for high1O2production. Here, we designed a TiO2:Yb,Ho,F-β-CD@DTX/HA nanoplatform using TiO2:Yb,Ho,F as the core, β-CD as the drug carrier, hyaluronic acid (HA) as the capping agent and target, and then applied it for 808 nm induced photodynamic-chemotherapy and 980 nm upconversion fluorescence/MR imaging. The results were as follows: (i) for TiO2as a photosensitizer, after doping Yb, Ho, F into TiO2, it could directly generate reactive oxygen species under an 808 nm laser; the dopants enhanced the absorption under the UV-Vis-NIR region and increased the electron-hole pair separation. (ii) For TiO2as the upconversion host, F and Ho also endowed TiO2:Yb,Ho,F with enhanced upconversion fluorescence under a 980 nm laser and T2-MRI contrast performance (r2= 30.71 mM-1s-1), respectively, thus, facilitating imaging for deep tissues. (iii) The HA shell outside of β-CD prevented the unexpected leaking of DTX, which improved the target abilities and achieved the enzyme-responsive drug release. The in vitro and in vivo studies also demonstrated the nanosystem could efficiently suppress tumor growth by combination therapy and had excellent imaging (UCL/MR) ability. Particularly, our work was the first example that utilized TiO2simultaneously as a photosensitizer and upconversion host, which simplified the core-shell UCNP-TiO2nanocomposites and reached a "win-win" cooperation in NIR-induced photodynamic therapy and UCL imaging.
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China. jie_0822paper @163.com yhchpaper@sina.com and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province 450001, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China. jie_0822paper @163.com yhchpaper@sina.com.
authors.forename: Pei
authors.initials: P
authors.lastname: Luo
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China. jie_0822paper @163.com yhchpaper@sina.com.
authors.forename: Chong
authors.initials: C
authors.lastname: Sun
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China. jie_0822paper @163.com yhchpaper@sina.com.
authors.forename: Lingchang
authors.initials: L
authors.lastname: Meng
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China. jie_0822paper @163.com yhchpaper@sina.com.
authors.forename: Weiran
authors.initials: W
authors.lastname: Ye
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China. jie_0822paper @163.com yhchpaper@sina.com.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China. jie_0822paper @163.com yhchpaper@sina.com and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province 450001, P.R. China.
authors.forename: Bin
authors.identifier: http://orcid.org/0000-0002-9442-1177
authors.initials: B
authors.lastname: Du
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles; D008674:Metals, Rare Earth; D051379:Mice; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D014025:Titanium; D023041:Xenograft Model Antitumor Assays
chemical_list: D004337:Drug Carriers; D008674:Metals, Rare Earth; D017319:Photosensitizing Agents; C009495:titanium dioxide; D014025:Titanium