title: Dangerous Liaisons: Deviant Endothelium NOTCHes toward Tumor Metastasis.
abstract: In this issue of Cancer Cell, Wieland et al. uncover a feedback loop in which tumor cells, by augmenting Notch signaling, provoke a senescent and pro-inflammatory state in endothelial cells, promoting neutrophil infiltration, tumor cell adhesion, and metastasis. Interfering with this Notch-dependent crosstalk may be a therapeutic approach to block metastasis.
authors.affiliation: Department of Medicine, Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine, New York, NY 10021, USA.
authors.forename: Peipei
authors.initials: P
authors.lastname: Guo
authors.affiliation: Department of Medicine, Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: srafii@med.cornell.edu.
authors.forename: Shahin
authors.initials: S
authors.lastname: Rafii
mesh_terms: D002448:Cell Adhesion; D045744:Cell Line, Tumor; D042783:Endothelial Cells / Q000378:metabolism; D004727:Endothelium; D004730:Endothelium, Vascular; D006801:Humans; D015398:Signal Transduction