title: Improvement of radiocephalic fistula maturation: rationale and design of the Liposomal Prednisolone to Improve Hemodialysis Fistula Maturation (LIPMAT) study - a randomized controlled trial.
abstract: BACKGROUND
  Non-maturation is a frequent complication of radiocephalic arteriovenous fistulas (RCAVF). In an animal model, liposomal prednisolone improved maturation of experimental fistulas. The Liposomal Prednisolone to Improve Hemodialysis Fistula Maturation (LIPMAT) study investigates if liposomal prednisolone improves RCAVF maturation.
  
  
  RESULTS
  The LIPMAT study is an investigator-initiated, multicenter, double-blinded, placebo-controlled randomized controlled trial with 1:1 randomization to liposomal prednisolone or placebo. Eighty patients receiving an RCAVF will be included. The primary outcome is the cephalic vein diameter six weeks after surgery, measured by ultrasound. The LIPMAT study started in May 2016. Enrollment is expected to be completed by the end of 2017.
  
  
  CONCLUSIONS
  The LIPMAT study is the first to evaluate the efficacy of liposomal prednisolone to enhance RCAVF maturation.
authors.affiliation: Departments of Internal Medicine and Vascular Surgery, Leiden University Medical Center, Leiden - The Netherlands.
authors.forename: Bram M
authors.initials: BM
authors.lastname: Voorzaat
authors.affiliation: Departments of Internal Medicine and Vascular Surgery, Leiden University Medical Center, Leiden - The Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: van Schaik
authors.affiliation: Departments of Internal Medicine and Vascular Surgery, Leiden University Medical Center, Leiden - The Netherlands.|Department of Vascular Surgery, Haaglanden Medical Center, The Hague - The Netherlands.
authors.forename: Koen E A
authors.initials: KE
authors.lastname: van der Bogt
authors.affiliation: Departments of Nephrology and Vascular Surgery, Academic Medical Center, Amsterdam - The Netherlands.
authors.forename: Liffert
authors.initials: L
authors.lastname: Vogt
authors.affiliation: Departments of Nephrology and Vascular Surgery, Academic Medical Center, Amsterdam - The Netherlands.
authors.forename: Laurens
authors.initials: L
authors.lastname: Huisman
authors.affiliation: Department of Nephrology, Alrijne Hospital, Leiderdorp - The Netherlands.
authors.forename: Bas A Th F
authors.initials: BA
authors.lastname: Gabreëls
authors.affiliation: Departments of Nephrology and Vascular Surgery, Haga Hospital, The Hague - The Netherlands.
authors.forename: Irene M
authors.initials: IM
authors.lastname: van der Meer
authors.affiliation: Departments of Nephrology and Vascular Surgery, Haga Hospital, The Hague - The Netherlands.
authors.forename: Randolph G S
authors.initials: RG
authors.lastname: van Eps
authors.affiliation: Department of Vascular Surgery, Haaglanden Medical Center, The Hague - The Netherlands.
authors.forename: Daniël
authors.initials: D
authors.lastname: Eefting
authors.affiliation: Departments of Nephrology and Vascular Surgery, OLVG, Amsterdam - The Netherlands.
authors.forename: Marcel C
authors.initials: MC
authors.lastname: Weijmer
authors.affiliation: Departments of Nephrology and Vascular Surgery, OLVG, Amsterdam - The Netherlands.
authors.forename: Han O
authors.initials: HO
authors.lastname: Groeneveld
authors.affiliation: Departments of Nephrology and Vascular Surgery, OLVG, Amsterdam - The Netherlands.
authors.forename: Roos C
authors.initials: RC
authors.lastname: van Nieuwenhuizen
authors.affiliation: Department of Nephrology, Reinier de Graaf Hospital, Delft - The Netherlands.
authors.forename: Henk
authors.initials: H
authors.lastname: Boom
authors.affiliation: Department of Nephrology, Spaarne Hospital, Haarlem - The Netherlands.
authors.forename: Cornelis A
authors.initials: CA
authors.lastname: Verburgh
authors.affiliation: Department of Nephrology, Tergooi Hospital, Hilversum - The Netherlands.
authors.forename: Karien
authors.initials: K
authors.lastname: van der Putten
authors.affiliation: Departments of Internal Medicine and Vascular Surgery, Leiden University Medical Center, Leiden - The Netherlands.
authors.forename: Joris I
authors.initials: JI
authors.lastname: Rotmans
mesh_terms: D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects / Q000379:methods*; D002985:Clinical Protocols; D004311:Double-Blind Method; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D008081:Liposomes; D009426:Netherlands; D011239:Prednisolone / Q000008:administration & dosage* / Q000009:adverse effects; D017534:Radial Artery / Q000503:physiopathology / Q000601:surgery*; D006435:Renal Dialysis; D012107:Research Design; D016896:Treatment Outcome; D014463:Ultrasonography; D034941:Upper Extremity / Q000098:blood supply*; D014654:Vascular Patency; D014680:Veins / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*
chemical_list: D005938:Glucocorticoids; D008081:Liposomes; D011239:Prednisolone