title: Mitotic Gene Bookmarking: An Epigenetic Mechanism for Coordination of Lineage Commitment, Cell Identity and Cell Growth.
abstract: Epigenetic control of gene expression contributes to dynamic responsiveness of cellular processes that include cell cycle, cell growth and differentiation. Mitotic gene bookmarking, retention of sequence-specific transcription factors at target gene loci, including the RUNX regulatory proteins, provide a novel dimension to epigenetic regulation that sustains cellular identity in progeny cells following cell division. Runx transcription factor retention during mitosis coordinates physiological control of cell growth and differentiation in a broad spectrum of biological conditions, and is associated with compromised gene expression in pathologies that include cancer.
authors.affiliation: Department of Biochemistry and University of Vermont Cancer Center, The Larner College of Medicine, University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
authors.forename: Sayyed K
authors.initials: SK
authors.lastname: Zaidi
authors.affiliation: Department of Biochemistry and University of Vermont Cancer Center, The Larner College of Medicine, University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
authors.forename: Jane B
authors.initials: JB
authors.lastname: Lian
authors.affiliation: Departments of Orthopedic Surgery & Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
authors.forename: Andre
authors.initials: A
authors.lastname: van Wijnen
authors.affiliation: Department of Biochemistry and University of Vermont Cancer Center, The Larner College of Medicine, University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stein
authors.affiliation: Department of Biochemistry and University of Vermont Cancer Center, The Larner College of Medicine, University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA. gary.stein@uvm.edu.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Stein
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D019070:Cell Lineage / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D008938:Mitosis / Q000235:genetics*
keywords: Epigenetic control; Gene expression; Mitotic bookmarking; RUNX