title: Sleep Deprivation Induced Plasma Amyloid-β Transport Disturbance in Healthy Young Adults.
abstract: Sleep is an important physiological process and beneficial in the removal of brain metabolites and functional recovery. Prior studies have shown that sleep disorders are significant risk factors for Alzheimer's disease (AD).
  
  
  
  The present study was designed to characterize the effect of short-term total sleep deprivation (TSD) on plasma amyloid-β (Aβ) concentrations.
  
  
  
  A clinical trial was conducted between March 1, 2016, and April 1, 2016. Twenty volunteers (age 27.3±3.4 years) with normal cognitive function and sleeping habits were recruited from the local population. Participants underwent 24 h of TSD. Periprocedural blood samples were collected to compare the changes of plasma Aβ42, Aβ40, low-density lipoprotein receptor-related protein (sLRP-1), soluble receptors for advanced glycation end products (sRAGE), and serum superoxide dismutase (SOD) and malonaldehyde (MDA).
  
  
  
  TSD increased morning plasma Aβ40 levels by 32.6% (p < 0.001) and decreased the Aβ42/Aβ40 ratio by 19.3% (p < 0.001). A positive relationship was found between TSD duration and plasma Aβ40 level (r = 0.51, p < 0.001) and Aβ40/Aβ42 ratio (r = 0.25, p = 0.003). Plasma concentrations of sLRP1 (p = 0.018) and sRAGE (p = 0.001) decreased significantly after TSD. Aβ40 and Aβ42 plasma concentrations correlated with plasma levels of sLRP1 and sRAGE. Serum SOD decreased after TSD (p = 0.005), whereas serum MDA was increased (p = 0.001).
  
  
  
  Sleep deprivation can lead to an elevation of plasma Aβ40 and decrease of the Aβ42/Aβ40 ratio. The underlying mechanisms may be related to increased oxidative stress and impaired peripheral Aβ clearance as pathomechanisms of AD.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wei
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Beiyu
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Huo
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yongning
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Suhang
authors.initials: S
authors.lastname: Shang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Louyan
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Liangjun
authors.initials: L
authors.lastname: Dang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Wei
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Juanli
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Hailei
authors.initials: H
authors.lastname: Yang
authors.affiliation: Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Qiumin
authors.initials: Q
authors.lastname: Qu
mesh_terms: D000328:Adult; D016229:Amyloid beta-Peptides / Q000097:blood*; D005260:Female; D006801:Humans; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010446:Peptide Fragments / Q000097:blood*; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood; D012892:Sleep Deprivation / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors; D055815:Young Adult
chemical_list: C000593871:AGER protein, human; D016229:Amyloid beta-Peptides; C475476:LRP1 protein, human; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D010446:Peptide Fragments; D000067759:Receptor for Advanced Glycation End Products; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); D008315:Malondialdehyde; D013482:Superoxide Dismutase
keywords: Alzheimer’s disease; amyloid-β; sleep; sleep deprivation