title: Sensitivity to Antimicrobial Drugs ofPseudomonas AeruginosaExtreme-Resistant Strains Isolated in the Major Hospitals of Central Kazakhstan.
abstract: OBJECTIVE
  The article presents the current data on the sensitivity of the main 37 strains of eXtremaly Drugs Resistance (XDR) category to anti-pseudomonas drugs.
  
  
  METHODS
  The strains were collected during the prospective multicenter study in large multidisciplinary hospitals of Central Kazakhstan. Susceptibility to antimicrobial drugs was carried out by disk method and the serial dilution method with the interpretation of the results according to EUCAST criteria. Detection of carbapenemases gene of VIM, IMP, NDM and GES classes was carried out by PCR method using the commercial kits.
  
  
  RESULTS
  All identified carbapenemases were sorted to VIM class and accounted for 63.64%. Resistance to aminoglycoside drugs exceeded 80%. All the strains were susceptible to polymyxin.
  
  
  CONCLUSIONS
  Thus, at the present stage the circulation of P. aeruginosa strains of XDR category continues in major hospitals in Kazakhstan. The strains remain sensitiveness only to polymyxin.
authors.affiliation: Institute of Antimicrobial Hemotherapy, Smolensk, Russia.
authors.forename: Ilya S
authors.initials: IS
authors.lastname: Azizov
authors.affiliation: Karaganda State Medical University, National Scientific Medical Center, Karaganda, Kazakhstan.
authors.forename: Alyona V
authors.initials: AV
authors.lastname: Lavrinenko
authors.affiliation: Karaganda State Medical University, National Scientific Medical Center, Karaganda, Kazakhstan.
authors.forename: Ilya A
authors.initials: IA
authors.lastname: Belyaev
authors.affiliation: Karaganda State Medical University, National Scientific Medical Center, Karaganda, Kazakhstan.
authors.forename: Dmitry B
authors.initials: DB
authors.lastname: Babenko
authors.affiliation: Institute of Antimicrobial Hemotherapy, Smolensk, Russia.
authors.forename: Natalya A
authors.initials: NA
authors.lastname: Shambilova
authors.affiliation: Karaganda State Medical University, National Scientific Medical Center, Karaganda, Kazakhstan.
authors.forename: Nelya M
authors.initials: NM
authors.lastname: Bissenova
keywords: Antibiotic resistance; MALDI-TOF; Pseudomonas aeruginosa; VIM; carbapenemases gene