title: Radiographic and Histological Evaluation of the Healing of Extraction Sockets Filled With Bovine-Derived Xenograft: An Experimental Study in Rats.
abstract: OBJECTIVE
  To evaluate the microenvironment changes in the sockets substituted with bovine-derived xenografts during the early healing period.
  
  
  METHODS
  After extraction of the right maxillary incisor of Sprague Dawley rats, 48 rats were randomly divided into 2 groups. The extraction sockets of the test group were filled with Bio-Oss, whereas the control group was allowed to heal without intervention. The bone quality of the extraction sockets was observed through micro-CT and immunohistochemistry.
  
  
  RESULTS
  Micro-CT scanning showed that the bone mineral density in the test group was significantly higher than that in the control group during the early healing period, whereas immunohistochemistry showed that the bone formation-related factors were significantly different between the test and control groups.
  
  
  CONCLUSIONS
  The bovine-derived xenografts may interfere with the healing process of the extraction socket in the early healing stage. Bone formation of the extraction socket was delayed after grafting with bone substitute.
authors.affiliation: *Doctoral Student, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China, Geriatric Dentistry Department, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China. †Doctoral Student, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, People's Republic of China; Doctoral Student, Dental Implant Center, West China Hospital of Stomatology, National Clinical Key Specialty on Oral Implantology, Sichuan University, Chengdu, Sichuan, People's Republic of China. ‡Postgraduate Student, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, People's Republic of China; Postgraduate Student, Dental Implant Center, West China Hospital of Stomatology, National Clinical Key Specialty on Oral Implantology, Sichuan University, Chengdu, Sichuan, People's Republic of China. §Professor, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, People's Republic of China; Professor, Dental Implant Center, West China Hospital of Stomatology, National Clinical Key Specialty on Oral Implantology, Sichuan University, Chengdu, Sichuan, People's Republic of China. ‖Professor, Geriatric Dentistry Department, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Zhou
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zheng
authors.forename: Meng
authors.initials: M
authors.lastname: Xie
authors.forename: Anchun
authors.initials: A
authors.lastname: Mo
authors.forename: Hongkun
authors.initials: H
authors.lastname: Wu
mesh_terms: D000818:Animals; D015519:Bone Density; D002417:Cattle; D007150:Immunohistochemistry; D007180:Incisor / Q000601:surgery; D008297:Male; D008437:Maxilla / Q000601:surgery; D008903:Minerals / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014081:Tooth Extraction; D020390:Tooth Socket / Q000000981:diagnostic imaging / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*; D055114:X-Ray Microtomography
chemical_list: C077540:Bio-Oss; D008903:Minerals