title: White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine.
abstract: Prenatal cocaine exposure (PCE) is associated with risk-taking behaviors, including increased initiation of substance use in adolescence. The neurobiological underpinnings of these behaviors in adolescents with PCE are not well understood. The goal of this study was to compare diffusion-weighted imaging data between adolescents with and without PCE using crossing-fiber models, which may provide more comprehensive estimates of white-matter microstructure within regions of multiple (e.g., primary and secondary) fiber orientations.
  
  
  
  Thirty-nine PCE individuals and 17 comparably aged prenatally non-drug-exposed (NDE) youths were recruited from a longitudinal cohort followed since birth. White matter was examined using tensor-derived and crossing-fiber models. Whole-brain investigations were performed, as were analyses on seven white-matter regions, which included the splenium, body and genu of the corpus callosum, bilateral cingulum, and the right and left superior longitudinal fasciculus (SLF).
  
  
  
  Whole-brain analyses revealed no group differences. However, ROI analyses for anisotropy estimates derived from the crossing-fiber model revealed significant group differences for secondary fibers, with reduced anisotropy among PCE adolescents compared to prenatally non-exposed youth in the right cingulum and the left SLF, and increased anisotropy in the genu.
  
  
  
  Our findings suggest that white-matter differences in PCE adolescents are subtle and localized primarily within secondary fiber orientations, perhaps arising from altered white-matter development.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA. Electronic address: Kristen.morie@yale.edu.
authors.forename: Kristen P
authors.initials: KP
authors.lastname: Morie
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA; National Center on Addictions and Substance Abuse, Yale University School of Medicine, New Haven, CT, 06510, USA.
authors.forename: Sarah W
authors.initials: SW
authors.lastname: Yip
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA.
authors.forename: Zu Wei
authors.initials: ZW
authors.lastname: Zhai
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA.
authors.forename: Jiansong
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Psychology, University of Maryland, College Park, MD, 20742 USA.
authors.forename: Kristen R
authors.initials: KR
authors.lastname: Hamilton
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA; Child Study Center, Yale University School of Medicine, New Haven, CT, 06510, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06510, USA.
authors.forename: Rajita
authors.initials: R
authors.lastname: Sinha
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA; Child Study Center, Yale University School of Medicine, New Haven, CT, 06510, USA.
authors.forename: Linda C
authors.initials: LC
authors.lastname: Mayes
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA; National Center on Addictions and Substance Abuse, Yale University School of Medicine, New Haven, CT, 06510, USA; Child Study Center, Yale University School of Medicine, New Haven, CT, 06510, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06510, USA; Connecticut Mental Health Center, New Haven, CT, 06519, USA.
authors.forename: Marc N
authors.initials: MN
authors.lastname: Potenza
mesh_terms: D000293:Adolescent; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D003042:Cocaine / Q000009:adverse effects*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008297:Male; D059906:Neuroimaging; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology*; D066127:White Matter / Q000473:pathology*
chemical_list: D003042:Cocaine
keywords: Cocaine; DTI; Pre-natal exposure; Substance abuse; White matter