title: Focus Issue: Cancer-Beyond tumor genetics to protein landscapes.
abstract: The proteins that regulate cell proliferation, metastatic potential, survival in circulation, and immune evasion represent most of the targets for therapeutic intervention in cancer. Furthermore, genomic profiling of just the cancer cells leaves critical information about the tumor microenvironment in the dark. The articles highlighted in this Focus Issue describe efforts to translate genomic data into knowledge of aberrant signaling that can be therapeutically targeted and strategies to explore not only the changes that occur in the protein landscape of the tumors but also in the protein profiles of the tumor microenvironment.
authors.affiliation: Associate Editor, Science Signaling, AAAS, Washington, DC 20005, USA. lferrare@aaas.org.
authors.forename: Leslie K
authors.initials: LK
authors.lastname: Ferrarelli
authors.affiliation: Editor, Science Signaling, AAAS, Washington, DC 20005, USA.
authors.forename: Nancy R
authors.identifier: http://orcid.org/0000-0001-5179-8890
authors.initials: NR
authors.lastname: Gough