title: Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries.
abstract: Spinal cord injury (SCI) is a devastating neurological condition that affects individuals worldwide, significantly reducing quality of life, for both patients and their families. In recent years there has been a growing interest in cell therapy potential in the context of spinal cord injuries. The present review aims to discuss and compare the restorative approaches based on the current knowledge, available spinal cord restorative cell therapies, and use of selected cell types. However, treatment options for spinal cord injury are limited, but rehabilitation and experimental technologies have been found to help maintain or improve remaining nerve function in some cases. Mesenchymal stem cells as well as olfactory ensheathing cells seem to show therapeutic impact on damaged spinal cord and might be useful in neuroregeneration. Recent research in animal models and first human trials give patients with spinal cord injuries hope for recovery.
authors.affiliation: Department of Pathophysiology, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
authors.forename: Zadroga
authors.initials: Z
authors.lastname: Anna
authors.affiliation: Department of Neurology and Neurosurgery, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
authors.forename: Jezierska-Woźniak
authors.identifier: 0000-0002-0571-8877
authors.initials: JW
authors.lastname: Katarzyna
authors.affiliation: Department of Pathophysiology, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
authors.forename: Czarzasta
authors.initials: C
authors.lastname: Joanna
authors.affiliation: Department of Neurology and Neurosurgery, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Barczewska
authors.affiliation: Department of Pathophysiology, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland; Laboratory for Regenerative Medicine, Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland; Foundation for the Nerve Cells Regeneration, Olsztyn, Poland.
authors.forename: Wojtkiewicz
authors.identifier: 0000-0003-0856-3644
authors.initials: W
authors.lastname: Joanna
authors.affiliation: Department of Neurology and Neurosurgery, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
authors.forename: Maksymowicz
authors.initials: M
authors.lastname: Wojciech