title: Role of breast magnetic resonance imaging in predicting residual lobular carcinoma in situ after initial excision.
abstract: BACKGROUND
  Breast magnetic resonance (MR) imaging is a useful screening modality in detecting suspicious lesions in patients with a history of lobular carcinoma in situ (LCIS). This study aimed to evaluate the effectiveness of breast MR imaging in detecting remnant LCIS lesions after initial excision.
  
  
  METHODS
  Between 2011 and 2015, 29 patients with LCIS who underwent initial excision were enrolled. Breast ultrasonography and breast MR imaging was conducted after initial excision. Imaging findings were compared with pathologic results.
  
  
  RESULTS
  There were nine (31.0%) cases with positive margins after initial excision; they were LCIS (n=8) and atypical lobular hyperplasia (n=1). Residual lesions were identified in 12 cases; they were invasive lobular carcinoma (n=1; 3.4%), LCIS (n=9; 31.0%), atypical lobular hyperplasia (n=1; 3.4%), and papillary carcinoma in situ (n=1; 3.4%). Prior to the second operation, these lesions could be detected in seven cases using ultrasonography (sensitivity, 53.3%; specificity, 100%) and in 10 cases using breast MR imaging (sensitivity, 83.3%; specificity, 100%).
  
  
  CONCLUSIONS
  Breast MR imaging showed higher sensitivity than breast ultrasonography in detecting remnant LCIS lesions. If a suspicious lesion was found using breast MR imaging, a second operation should be considered because of the possibility of multifocality, even if LCIS was confirmed at the initial operation.
authors.affiliation: Department of Surgery, Kyungpook National University, School of Medicine, Daegu, Republic of Korea.
authors.forename: Ryu Kyung
authors.initials: RK
authors.lastname: Lee
authors.affiliation: Department of Radiology, Kyungpook National University, School of Medicine, Daegu, Republic of Korea.
authors.forename: Hye Jung
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Surgery, Kyungpook National University, School of Medicine, Daegu, Republic of Korea. Electronic address: drjeeyeon@naver.com.
authors.forename: Jeeyeon
authors.initials: J
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000071960:Breast Carcinoma In Situ / Q000000981:diagnostic imaging* / Q000601:surgery; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D000072662:Margins of Excision; D008408:Mastectomy; D008875:Middle Aged; D018365:Neoplasm, Residual; D011182:Postoperative Care / Q000379:methods*; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary
keywords: MR; breast; carcinoma; lobular