title: To Find a Better Dosimetric Parameter in the Predicting of Radiation-Induced Lung Toxicity Individually: Ventilation, Perfusion or CT based.
abstract: This study aimed to find a better dosimetric parameter in predicting of radiation-induced lung toxicity (RILT) in patients with non-small cell lung cancer (NSCLC) individually: ventilation(V), perfusion (Q) or computerized tomography (CT) based. V/Q single-photon emission computerized tomography (SPECT) was performed within 1 week prior to radiotherapy (RT). All V/Q imaging data was integrated into RT planning system, generating functional parameters based on V/Q SPECT. Fifty-seven NSCLC patients were enrolled in this prospective study. Fifteen (26.3%) patients underwent grade ≥2 RILT, the remaining forty-two (73.7%) patients didn't. Q-MLD, Q-V20, V-MLD, V-V20 of functional parameters correlated more significantly with the occurrence of RILT compared to V20, MLD of anatomical parameters (r = 0.630; r = 0.644; r = 0.617; r = 0.651 vs. r = 0.424; r = 0.520 p < 0.05, respectively). In patients with chronic obstructive pulmonary diseases (COPD), V functional parameters reflected significant advantage in predicting RILT; while in patients without COPD, Q functional parameters reflected significant advantage. Analogous results were existed in fractimal analysis of global pulmonary function test (PFT). In patients with central-type NSCLC, V parameters were better than Q parameters; while in patients with peripheral-type NSCLC, the results were inverse. Therefore, this study demonstrated that choosing a suitable dosimetric parameter individually can help us predict RILT accurately.
authors.affiliation: School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China.|Shandong Cancer Hospital and Institute- Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Xiao
authors.affiliation: Shandong Cancer Hospital and Institute- Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Guoren
authors.initials: G
authors.lastname: Yang
authors.affiliation: Shandong Cancer Hospital and Institute- Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Jinhu
authors.initials: J
authors.lastname: Chen
authors.affiliation: Shandong Cancer Hospital and Institute- Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wang
authors.affiliation: Shandong Cancer Hospital and Institute- Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Shandong Cancer Hospital and Institute- Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Zongwei
authors.initials: Z
authors.lastname: Huo
authors.affiliation: Shandong Cancer Hospital and Institute- Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Qingxi
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Shandong Cancer Hospital and Institute- Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Yu
authors.affiliation: Shandong Cancer Hospital and Institute- Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong, China.|Shandong Academy of Medical Sciences, Jinan, Shandong, China.
authors.forename: Shuanghu
authors.initials: S
authors.lastname: Yuan
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000528:radiation effects; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging* / Q000473:pathology; D011832:Radiation Injuries / Q000000981:diagnostic imaging* / Q000473:pathology; D011874:Radiometry; D011879:Radiotherapy Dosage; D012129:Respiratory Function Tests; D014057:Tomography, X-Ray Computed