title: Dissociation between complete hippocampal context memory formation and context fear acquisition.
abstract: Rodents require a minimal time period to explore a context prior to footshock to display plateau-level context fear at test. To investigate whether this rapid fear plateau reflects complete memory formation within that short time-frame, we used the immediate-early gene product Arc as an indicator of hippocampal context memory formation-related activity. We found that hippocampal Arc expression continued to increase well past the minimal time required for plateau-level fear. This raises the possibility that context fear conditioning occurs more rapidly than complete memory formation. Thus, animals may be able to condition robustly to both complete and incomplete contextual representations.
authors.affiliation: Neurodegenerative Disorders, Neuroscience Department, Garvan Institute of Medical Research, Sydney 2010, Australia.|School of Psychology, The University of Sydney, Sydney 2006, Australia.
authors.forename: Jessica
authors.initials: J
authors.lastname: Leake
authors.affiliation: Neurodegenerative Disorders, Neuroscience Department, Garvan Institute of Medical Research, Sydney 2010, Australia.|Faculty of Medicine, University of New South Wales, Sydney 2052, Australia.|School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney 2007, Australia.
authors.forename: Raphael
authors.initials: R
authors.lastname: Zinn
authors.affiliation: School of Psychology, The University of Sydney, Sydney 2006, Australia.
authors.forename: Laura
authors.initials: L
authors.lastname: Corbit
authors.affiliation: Neurodegenerative Disorders, Neuroscience Department, Garvan Institute of Medical Research, Sydney 2010, Australia.|Faculty of Medicine, University of New South Wales, Sydney 2052, Australia.|School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney 2007, Australia.
authors.forename: Bryce
authors.initials: B
authors.lastname: Vissel
mesh_terms: D000386:AIDS-Related Complex / Q000235:genetics / Q000378:metabolism; D000818:Animals; D003214:Conditioning, Classical; D004597:Electroshock / Q000009:adverse effects; D005239:Fear; D046352:Freezing Reaction, Cataleptic / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000378:metabolism; D013997:Time Factors
chemical_list: D012333:RNA, Messenger