title: Case report of nivolumab-related pneumonitis.
abstract: We report a case with suggestive antiprogrammed death-1 inhibitor-related pneumonitis in an endometrial cancer patient. This case presented with fever and cough after three dosages of nivolumab. Computed tomography initially showed centrilobular nodularities in a unilateral lung, which was compatible with aspiration pneumonia. However, diffuse ground-glass opacities (GGO) rapidly developed in the unilateral lung over 4 days despite the use of broad-spectrum antibiotics. Development of GGO was considered to be related to a nivolumab-mediated immune reaction. Corticosteroid was administered and the GGO subsequently disappeared. The present report focuses on the computed tomography diagnostic features of nivolumab-related pneumonitis. The accumulation of knowledge regarding various types of antiprogrammed death-1-related pneumonitis will lead to appropriate treatment for this newly emerging adverse event.
authors.affiliation: Laboratory for Joint Research & Development, St. Luke's International University, Tokyo, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Tada
authors.affiliation: Department of Radiology, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kurihara
authors.affiliation: Department of Oncology & Hematology, Edogawa Hospital, Tokyo, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Myojo
authors.affiliation: Department of Thoracic Surgery, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Fumitsugu
authors.initials: F
authors.lastname: Kojima
authors.affiliation: Department of Thoracic Surgery, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Ishikawa
authors.affiliation: Department of Thoracic Surgery, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Yoshiyasu
authors.affiliation: Department of Hematology, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Morimoto
authors.affiliation: Department of Hematology, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Ito
authors.affiliation: Department of Hematology, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Koyamada
authors.affiliation: Department of Hematology, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Yamashita
authors.affiliation: Department of Thoracic Surgery, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Bando
authors.affiliation: Department of Hematology, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Mori
authors.affiliation: Immunotherapy & Cell Therapy Service, St. Luke's International Hospital, 9-1, Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan.|Laboratory for Joint Research & Development, St. Luke's International University, Tokyo, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Heike
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects / Q000379:methods*; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009362:Neoplasm Metastasis; D000077594:Nivolumab; D011014:Pneumonia / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D061026:Programmed Cell Death 1 Receptor / Q000276:immunology; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D000077594:Nivolumab; D008775:Methylprednisolone
keywords: PD-1 inhibitor; immune-related pneumonitis; nivolumab