title: Assessment of Gold Nanoparticle-Mediated-Enhanced Hyperthermia Using MR-Guided High-Intensity Focused Ultrasound Ablation Procedure.
abstract: High-intensity focused ultrasound (HIFU) has gained increasing popularity as a noninvasive therapeutic procedure to treat solid tumors. However, collateral damage due to the use of high acoustic powers during HIFU procedures remains a challenge. The objective of this study is to assess the utility of using gold nanoparticles (gNPs) during HIFU procedures to locally enhance heating at low powers, thereby reducing the likelihood of collateral damage. Phantoms containing tissue-mimicking material (TMM) and physiologically relevant concentrations (0%, 0.0625%, and 0.125%) of gNPs were fabricated. Sonications at acoustic powers of 10, 15, and 20 W were performed for a duration of 16 s using an MR-HIFU system. Temperature rises and lesion volumes were calculated and compared for phantoms with and without gNPs. For an acoustic power of 10 W, the maximum temperature rise increased by 32% and 43% for gNPs concentrations of 0.0625% and 0.125%, respectively, when compared to the 0% gNPs concentration. For the power of 15 W, a lesion volume of 0, 44.5 ± 7, and 63.4 ± 32 mm3was calculated for the gNPs concentration of 0%, 0.0625%, and 0.125%, respectively. For a power of 20 W, it was found that the lesion volume doubled and tripled for concentrations of 0.0625% and 0.125% gNPs, respectively, when compared to the concentration of 0% gNPs. We conclude that gNPs have the potential to locally enhance the heating and reduce damage to healthy tissue during tumor ablation using HIFU.
authors.affiliation: Department of Mechanical, Materials Engineering College of Engineering and Applied Science, University of Cincinnati , Cincinnati, Ohio 45221, United States.
authors.forename: Surendra B
authors.initials: SB
authors.lastname: Devarakonda
authors.affiliation: Division of Solid and Fluid Mechanics Center for Devices and Radiological Health, U.S. Food and Drug Administration , Silver Spring, Maryland 20993, United States.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Myers
authors.affiliation: Department of Radiology, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio 45221, United States.
authors.forename: Mathew
authors.initials: M
authors.lastname: Lanier
authors.affiliation: Department of Radiology, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio 45221, United States.
authors.forename: Charles
authors.initials: C
authors.lastname: Dumoulin
authors.affiliation: Department of Mechanical, Materials Engineering College of Engineering and Applied Science, University of Cincinnati , Cincinnati, Ohio 45221, United States.
authors.forename: Rupak K
authors.identifier: 0000-0002-7235-9560
authors.initials: RK
authors.lastname: Banerjee
mesh_terms: D000162:Acoustics; D000465:Algorithms; D003198:Computer Simulation; D006046:Gold / Q000737:chemistry*; D057086:High-Intensity Focused Ultrasound Ablation / Q000295:instrumentation*; D006801:Humans; D006979:Hyperthermia, Induced; D008279:Magnetic Resonance Imaging / Q000379:methods; D053768:Metal Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000628:therapy; D010316:Particle Size; D019047:Phantoms, Imaging; D013499:Surface Properties; D013696:Temperature
chemical_list: D006046:Gold
keywords: HIFU; High intensity focused ultrasound; MRI; cancer therapy; gold nanoparticles; hyperthermia