title: Interleukin-1 Receptor Antagonist and Interleukin-4 Genes Variable Number Tandem Repeats Are Associated with Adiposity in Malaysian Subjects.
abstract: Interleukin-1 receptor antagonist (IL1RA) intron 2 86 bp repeat and interleukin-4 (IL4) intron 3 70 bp repeat are variable number tandem repeats (VNTRs) that have been associated with various diseases, but their role in obesity is elusive. The objective of this study was to investigate the association ofIL1RAandIL4VNTRs with obesity and adiposity in 315 Malaysian subjects (128 M/187 F; 23 Malays/251 ethnic Chinese/41 ethnic Indians). The allelic distributions ofIL1RAandIL4were significantly different among ethnicities, and the alleles were associated with total body fat (TBF) classes. Individuals withIL1RAI/II genotype or allele II had greater risk of having higher overall adiposity, relative to those having the I/I genotype or I allele, respectively, even after controlling for ethnicity [Odds Ratio (OR) of I/II genotype = 12.21 (CI = 2.54, 58.79;p= 0.002); II allele = 5.78 (CI = 1.73, 19.29;p= 0.004)]. However,IL4VNTR B2 allele was only significantly associated with overall adiposity status before adjusting for ethnicity [OR = 1.53 (CI = 1.04, 2.23;p= 0.03)]. Individuals withIL1RAII allele had significantly higher TBF than those with I allele (31.79 ± 2.52versus23.51 ± 0.40;p= 0.005). Taken together,IL1RAintron 2 VNTR seems to be a genetic marker for overall adiposity status in Malaysian subjects.
authors.affiliation: Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR), Kampar Campus, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia.
authors.forename: Yung-Yean
authors.initials: YY
authors.lastname: Kok
authors.affiliation: Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR), Kampar Campus, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia.
authors.forename: Hing-Huat
authors.initials: HH
authors.lastname: Ong
authors.affiliation: Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR), Kampar Campus, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia.
authors.forename: Yee-How
authors.identifier: 0000-0002-8554-049X
authors.initials: YH
authors.lastname: Say
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D005006:Ethnicity; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D018598:Minisatellite Repeats; D009765:Obesity / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: C507763:IL1RN protein, human; C508598:IL4 protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D015847:Interleukin-4