title: Increased Coagulation and Decreased Fibrinolysis as Measured with Overall Hemostatic Potential Are Dependent on BMI and Not Associated with PCOS.
abstract: Overall hemostatic potential (OHP) captures all factors that affect coagulation and fibrinolysis cascade. It has not yet been assessed in polycystic ovary syndrome (PCOS). The aim of the study was to identify the relationship of OHP with a syndrome per se and body mass index (BMI).
  
  
  
  In 90 women with PCOS aged 30.9 ± 8.1 years (50 obese, 13 overweight, and 27 lean) and 21 healthy age-matched controls (11 obese and 10 lean), OHP with overall coagulation potential (OCP) and overall fibrinolytic potential (OFP) was determined spectrophotometrically. OFP was calculated.
  
  
  
  OHP increased with BMI in PCOS (9.6 ± 2.3 in lean, 12.5 ± 5.1 in overweight, and 15.5 ± 3.8 Abs-sum in obese) and in controls (9.1 ± 1.0 in lean and 17.3 ± 4.6 Abs-sum in obese). There was significant difference between lean and obese PCOS (P < 0.001) and between lean and obese controls (P < 0.001). OCP also increased with BMI in PCOS (P < 0.001 for lean vs. obese) and in controls (P < 0.001 for lean vs. obese). OFP decreased with BMI in PCOS (P < 0.001 for obese vs. overweight vs. lean) and in controls (P < 0.001 for obese vs. lean). OHP in healthy obese and obese PCOS did not differ significantly, while OHP for healthy obese was increased in comparison to overweight and lean PCOS (P < 0.001).
  
  
  
  PCOS was not associated with increased OHP compared with BMI and age-matched controls. However, increase in OHP was positively associated with BMI in PCOS and healthy women.
authors.affiliation: 1 Department of Endocrinology and Diabetology, University Medical Centre Maribor , Maribor, Slovenia .
authors.forename: Matej
authors.initials: M
authors.lastname: Rakusa
authors.affiliation: 2 Department of Endocrinology, Diabetes and Metabolic Disease, University Medical Centre Ljubljana , Ljubljana, Slovenia .
authors.forename: Mojca
authors.initials: M
authors.lastname: Jensterle
authors.affiliation: 3 Laboratory for Haemostasis and Atherothrombosis, University Medical Centre Ljubljana , Ljubljana, Slovenia .
authors.forename: Mojca
authors.initials: M
authors.lastname: Božič-Mijovski
authors.affiliation: 2 Department of Endocrinology, Diabetes and Metabolic Disease, University Medical Centre Ljubljana , Ljubljana, Slovenia .
authors.forename: Andrej
authors.initials: A
authors.lastname: Janez
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000502:physiology*; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D003430:Cross-Sectional Studies; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood; D050177:Overweight / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*
keywords: body mass index; coagulation; fibrinolysis; polycystic ovary syndrome