title: Design, synthesis, and biological evaluation of a highly water-soluble psoralen-based photosensitizer.
abstract: In recent years, photodynamic therapy (PDT) has been approved for treating various medical conditions, including cancer. PDT is a treatment that employs a particular drugs, called photosensitizers which work along with specific light source. The growth of this medical industry is expanding as it is another promising alternative to treat cancer which lessen the burden of treatments in patients. This includes the benefits of minimally invasive procedures and delivering high accuracy in targeting mutations. In recent two decades, cancer researchers have produced remarkable studies on developing photosensitizers that enhance understanding of biology and genetics of cancer. It is unfortunate that not all PDT can work as well as other profound treatment because PDT has various limitations like PDT leads photosensitivity reaction that arises when the photosensitizer remains in the body for a long period of time. In this paper, our studies centers on synthesizing a highly soluble photosensitizing agent with improved effectiveness on detecting cancer cells.
authors.affiliation: Department of Materials Science, National Institute of Technology, Yonago College, Yonago City, Tottori 683-8502, Japan. Electronic address: uruma@yonago-k.ac.jp.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Uruma
authors.affiliation: Department of Materials Science, National Institute of Technology, Yonago College, Yonago City, Tottori 683-8502, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Nonomura
authors.affiliation: Department of Materials Science, National Institute of Technology, Yonago College, Yonago City, Tottori 683-8502, Japan.
authors.forename: Priscilla Yoong Mei
authors.initials: PY
authors.lastname: Yen
authors.affiliation: Department of Materials Science, National Institute of Technology, Yonago College, Yonago City, Tottori 683-8502, Japan.
authors.forename: Marie
authors.initials: M
authors.lastname: Edatani
authors.affiliation: Department of Materials Science, National Institute of Technology, Yonago College, Yonago City, Tottori 683-8502, Japan.
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Yamamoto
authors.affiliation: Department of Biomedical Sciences, Tottori University, Yonago City, Tottori 683-8503, Japan.
authors.forename: Kunishige
authors.initials: K
authors.lastname: Onuma
authors.affiliation: Department of Biomedical Sciences, Tottori University, Yonago City, Tottori 683-8503, Japan.
authors.forename: Futoshi
authors.initials: F
authors.lastname: Okada
mesh_terms: D016475:3T3 Cells; D000818:Animals; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D015195:Drug Design; D011564:Furocoumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D066244:Proton Magnetic Resonance Spectroscopy; D012995:Solubility; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014867:Water / Q000737:chemistry*
chemical_list: D011564:Furocoumarins; D017319:Photosensitizing Agents; D014867:Water