title: Signatures of DNA target selectivity by ETS transcription factors.
abstract: The ETS family of transcription factors is a functionally heterogeneous group of gene regulators that share a structurally conserved, eponymous DNA-binding domain. DNA target specificity derives from combinatorial interactions with other proteins as well as intrinsic heterogeneity among ETS domains. Emerging evidence suggests molecular hydration as a fundamental feature that defines the intrinsic heterogeneity in DNA target selection and susceptibility to epigenetic DNA modification. This perspective invokes novel hypotheses in the regulation of ETS proteins in physiologic osmotic stress, their pioneering potential in heterochromatin, and the effects of passive and pharmacologic DNA demethylation on ETS regulation.
authors.affiliation: a Department of Chemistry , Georgia State University , Atlanta , GA , USA.|b Center for Diagnostics and Therapeutics, Georgia State University , Atlanta , GA , USA.
authors.forename: Gregory M K
authors.identifier: 0000-0001-5107-9458
authors.initials: GMK
authors.lastname: Poon
authors.affiliation: a Department of Chemistry , Georgia State University , Atlanta , GA , USA.
authors.forename: Hye Mi
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D019175:DNA Methylation / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000502:physiology*; D006570:Heterochromatin / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009997:Osmotic Pressure / Q000502:physiology*; D000072417:Protein Domains; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics / Q000378:metabolism*
chemical_list: D006570:Heterochromatin; D050783:Proto-Oncogene Proteins c-ets; D004247:DNA
keywords: DNA methylation; ETS transcription factors; Ets-1; PU.1; epigenetics; molecular hydration; phylogeny