title: Ovarian function's role during cancer cachexia progression in the female mouse.
abstract: Cachexia is a debilitating condition that occurs with chronic disease, including cancer; our research has shown that some regulation of cancer cachexia progression is affected by sex differences. TheApcMin/+mouse is genetically predisposed to develop intestinal tumors; IL-6 signaling and hypogonadism are associated with cachexia severity in the male. This relationship in the female warrants further investigation, as we have shown that the ability of IL-6 to induce cachexia differs between the sexes. Since ovarian reproductive function relies on a complex system of endocrine signaling to affect whole body homeostasis, we examined the relationship between ovarian reproductive function and progression of cancer cachexia in the femaleApcMin/+mouse. Our study of ovarian reproductive function in femaleApcMin/+mice showed disease-related cessation of estrous cycling (acyclicity) in 38% of mice. Acyclicity, including morphological and functional losses and enhanced muscle inflammatory gene expression, was associated with severe cachexia. Interestingly, ovariectomy rescued body weight and muscle mass and function but increased muscle sensitivity to systemic IL-6 overexpression. In conclusion, our results provide evidence for a relationship between ovarian reproductive function and cachexia progression in femaleApcMin/+mice.
authors.affiliation: Integrative Muscle Biology Laboratory, Department of Exercise Science, University of South Carolina, Columbia, South Carolina.
authors.forename: Kimbell L
authors.initials: KL
authors.lastname: Hetzler
authors.affiliation: Integrative Muscle Biology Laboratory, Department of Exercise Science, University of South Carolina, Columbia, South Carolina.
authors.forename: Justin P
authors.initials: JP
authors.lastname: Hardee
authors.affiliation: Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina; and.
authors.forename: Holly A
authors.initials: HA
authors.lastname: LaVoie
authors.affiliation: Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina; and.
authors.forename: E Angela
authors.initials: EA
authors.lastname: Murphy
authors.affiliation: Integrative Muscle Biology Laboratory, Department of Exercise Science, University of South Carolina, Columbia, South Carolina; carsonj@mailbox.sc.edu.|Center for Colon Cancer Research, University of South Carolina, Columbia, South Carolina.
authors.forename: James A
authors.initials: JA
authors.lastname: Carson
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000150:complications / Q000503:physiopathology*; D000818:Animals; D002100:Cachexia / Q000209:etiology / Q000503:physiopathology*; D018450:Disease Progression; D030762:Estrous Cycle; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018482:Muscle, Skeletal / Q000503:physiopathology*; D010053:Ovary / Q000503:physiopathology*
keywords: ApcMin/+; IL-6, ovariectomy; cancer; inflammation