title: A Long-Term Survivor of Metastatic Pancreatic Adenocarcinoma: Free of Recurrence 12 Years After Treatment of Oligometastatic Disease.
abstract: Aggressive local therapy for patients with oligometastatic pancreatic ductal adenocarcinoma (PDAC) has traditionally not been pursued due to high rates of distant progression. We describe a 62-year-old male initially presenting with resectable PDAC who underwent the Whipple procedure but developed multiple liver metastases within two months of starting adjuvant gemcitabine. Oxaliplatin was added to the regimen and complete resolution of the liver lesions resulted. He remained disease-free for five years until re-staging revealed a small lung nodule. This was resected and confirmed to be metastatic PDAC. After additional adjuvant gemcitabine, the patient remained free of recurrence for 12 years after diagnosis of metastatic disease and ultimately passed away from complications of ascending cholangitis associated with stricture at the biliary-enteric anastomosis site. He had no evidence of disease recurrence at the time of death. Next-generation sequencing of the tumor was unrevealing, showing only an activating mutation of KRAS and a deleterious mutation of tumor protein p53 (TP53). Our case suggests that while the prognosis for metastatic PDAC is poor, the population is nonetheless heterogeneous. Prognostic biomarkers are needed for the identification of patients for whom aggressive local treatment of oligometastatic PDAC may be warranted.
authors.affiliation: Department of Therapeutic Radiology, Yale University School of Medicine.
authors.forename: John M
authors.initials: JM
authors.lastname: Stahl
authors.affiliation: Department of Pathology, Yale University School of Medicine.
authors.forename: Zenta
authors.initials: Z
authors.lastname: Walther
authors.affiliation: Radiation Oncology, Torrance Memorial Medical Center.
authors.forename: Bryan W
authors.initials: BW
authors.lastname: Chang
authors.affiliation: Department of Medical Oncology, Yale University School of Medicine.
authors.forename: Howard S
authors.initials: HS
authors.lastname: Hochster
authors.affiliation: Department of Therapeutic Radiology, Yale University School of Medicine.
authors.forename: Kimberly L
authors.initials: KL
authors.lastname: Johung
keywords: long-term survivor; metastatectomy; oligometastatic cancer; pancreatic adenocarcinoma