title: Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival.
abstract: BACKGROUND
  It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs.
  
  
  METHODS
  Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with allopurinol. Length of the necrotic zone was measured and recorded daily. At each phase, flaps were removed and sent for histopathological study after 1 week observation.
  
  
  RESULTS
  Mean length of the necrotic zone in allopurinol treated skin flaps has been significantly less than normal flaps over all 7 days of observation (p<0.0001). Histopathology study showed less inflammation and more normal tissue structure in the allopurinol treated skin flaps.
  
  
  CONCLUSIONS
  It was demonstrated that systemic administration of allopurinol significantly improved skin flap survival.
authors.affiliation: Department of Plastic Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Rasti Ardakani
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al-Dam
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Ashkan
authors.initials: A
authors.lastname: Rashad
authors.affiliation: Department of Plastic Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Shayesteh Moghadam
keywords: Allopurinol; Antioxidant; Skin flap; Survival