title: A New Perspective on the Risk of Hypercoagulopathy in Ovarian Hyperstimulation Syndrome Using Thromboelastography.
abstract: Thromboelastography (TEG) provides real-time assessment of hemostasis by measuring the viscoelastic properties, coagulation factor, and platelet activity in whole blood samples. In this prospective case-control study, we wanted to investigate whether blood clot formation assessment, using TEG, can identify a hypercoagulable state in women with severe ovarian hyperstimulation syndrome (OHSS). Thirty-six women who were hospitalized with severe OHSS were allocated to the OHSS group and 32 women undergoing controlled ovarian hyperstimulation but who did not develop OHSS were allocated to the control group. The TEG indices were compared between women with severe OHSS and controls. All the coagulation indices assessed by TEG were significantly different in the OHSS group compared to the controls, depicting a hypercoagulable state. Median coagulation index was 3.6 (interquartile range: 2.80-4.15) and 1.45 (interquartile range: 0.20-2.30) in study group and controls, respectively ( P < .001). Our results show that TEG can be used to depict a hypercoagulable state in women with severe OHSS.
authors.affiliation: 1 Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Lis Maternity Hospital, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Eyal
authors.initials: E
authors.lastname: Zohav
authors.affiliation: 1 Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Lis Maternity Hospital, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Benny
authors.initials: B
authors.lastname: Almog
authors.affiliation: 1 Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Lis Maternity Hospital, Tel Aviv University, Tel Aviv, Israel.|2 Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
authors.forename: Aviad
authors.initials: A
authors.lastname: Cohen
authors.affiliation: 1 Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Lis Maternity Hospital, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ishai
authors.initials: I
authors.lastname: Levin
authors.affiliation: 3 The Hematology Institute, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Varda
authors.initials: V
authors.lastname: Deutsch
authors.affiliation: 1 Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Lis Maternity Hospital, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ariel
authors.initials: A
authors.lastname: Many
authors.affiliation: 1 Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Lis Maternity Hospital, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ami
authors.initials: A
authors.lastname: Amit
authors.affiliation: 1 Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Lis Maternity Hospital, Tel Aviv University, Tel Aviv, Israel.|2 Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
authors.forename: Yoni
authors.initials: Y
authors.lastname: Cohen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications*; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013916:Thrombelastography / Q000379:methods*; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis*
keywords: hypercoagulability; ovarian hyperstimulation syndrome; thromboelastogram; thrombosis