title: Is regeneration inDrosophila the result of epimorphic regulation?
abstract: It has been known for many years that when a wing disc ofDrosophila is bisected, and the fragments cultured in adult females, regulation occurs and either a complete disc is regenerated or the fragment is duplicated. We have investigated how this regeneration process occurs. To establish which cells contribute to the regenerate, and thus determine if regeneration is the result of epimorphic regulation, fragments of discs, after culture in an adult for one to five days, were exposed to3H-thymidine to label replicating cells. Imaginal discs, both whole and as regenerating fragments, undergo some DNA replication which is distributed throughout the disc, but cut discs frequently show clusters of labelled cells around the wound, indicating that regeneration is probably epimorphic.
authors.affiliation: Department of Molecular Biology, University of Edinburgh, Kings Buildings, Mayfield Road, EH9 3JR, Edinburgh, Scotland.
authors.forename: Leslie
authors.initials: L
authors.lastname: Dale
authors.affiliation: Department of Molecular Biology, University of Edinburgh, Kings Buildings, Mayfield Road, EH9 3JR, Edinburgh, Scotland.
authors.forename: Mary
authors.initials: M
authors.lastname: Bownes
keywords: Drosophila; Epimorphic regulation; Imaginal discs