title: Microangiopathic hemolytic anemia in pregnancy.
abstract: Microangipathic hemolytic anemia (MAHA) is a serious diagnosis and difficult to manage in pregnant patients as multiple life threatening conditions could present with MAHA. ADAMTS13 enzyme activity can be affected during pregnancy with multiple factors. A persistent extremely low ADAMTS13 enzyme activity levels, without an inhibitor, after the delivery was an important factor to establish the diagnosis. We present a case of likely congenital ADAMST13 deficiency that manifested for the first time in a pregnant woman at week 37 of pregnancy.
authors.affiliation: University of Massachusetts Medical School, Department of Medicine, United States; University of Massachusetts Medical School, Department of Hematology and Oncology, United States. Electronic address: mohammed.salhab@umassmemorial.org.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Salhab
authors.affiliation: University of Massachusetts Medical School, Department of Medicine, United States.
authors.forename: Andrew
authors.initials: A
authors.lastname: Hsu
authors.affiliation: University of Massachusetts Medical School, Department of Medicine, United States.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Ryer
authors.affiliation: University of Massachusetts Medical School, Department of Medicine, United States; University of Massachusetts Medical School, Department of Hematology and Oncology, United States.
authors.forename: Juliet
authors.initials: J
authors.lastname: Appiah
authors.affiliation: University of Massachusetts Medical School, Department of Medicine, United States; University of Massachusetts Medical School, Department of Hematology and Oncology, United States.
authors.forename: Bradley
authors.initials: B
authors.lastname: Switzer
mesh_terms: D000328:Adult; D000743:Anemia, Hemolytic / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000473:pathology
keywords: ADAMST13; Microagiopathic hemolytic anemia (MAHA); Preeclampsia; Thrombotic thrombocytopenic purpura