title: Long-term results of periodontal regenerative therapy: A retrospective practice-based cohort study.
abstract: OBJECTIVE
  Evaluation of the long-term effectiveness of regenerative treatment of intra-bony defects in periodontal practice.
  
  
  METHODS
  A total of 1,008 intra-bony defects in 176 patients were analysed after using collagen-added deproteinized bovine bone mineral (DBBMc) with or without collagen membrane (CM) or enamel matrix derivative (EMD). Defects were classified as one- and two-wall and as shallow (≤6 mm), moderate (>6 and <11 mm) and deep (≥11 mm). Radiographic bone level changes were evaluated after 1 year, 2 to 4 years and 5 to 10 years.
  
  
  RESULTS
  Mean radiographic defect fill was 3.8 mm after 1 year and remained stable up to 10 years. Deep and moderate defects showed a higher degree of fill than shallow defects (53.3%, 49.2%, 42.9%). Tooth loss amounted to 2.6%, was dependent on initial defect size (1.2% shallow, 1.4% moderate, 5.7% deep defects) and occurred mainly due to endodontic reasons.
  
  
  CONCLUSIONS
  Within the limits of the retrospective study design, the findings indicate that periodontal treatment using DBBMc with or without CM or EMD can lead to long-term defect reduction and tooth survival for up to 10 years in the setting of a periodontal practice.
authors.affiliation: Private Practice for Periodontology, Aachen, Germany.
authors.forename: Frank
authors.identifier: http://orcid.org/0000-0002-5146-5452
authors.initials: F
authors.lastname: Bröseler
authors.affiliation: Private Practice for Periodontology, Aachen, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Tietmann
authors.affiliation: Private Practice, Hattingen, Germany.
authors.forename: Ann-Katrin
authors.initials: AK
authors.lastname: Hinz
authors.affiliation: Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.
authors.forename: Søren
authors.identifier: http://orcid.org/0000-0002-4160-5837
authors.initials: S
authors.lastname: Jepsen
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use; D003746:Dental Enamel Proteins / Q000627:therapeutic use; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D003746:Dental Enamel Proteins; D003094:Collagen
keywords: bovine bone mineral; collagen; compliance; enamel matrix protein; long-term; membrane; radiographic bone level; regenerative periodontal therapy