title: [Comparative Clinical Biochemical Assessment of the State of Myocardium After Coronary Artery Bypass Surgery Performed Using Various Techniques].
abstract: We compared parameters of the state of myocardium after coronary artery bypass surgery (CABS) performed according to the following techniques - with complete cardiopulmonary bypass (CABS-CBP), beating heart bypass grafting with parallel normothermic perfusion (CABS-BH-NP), and beating heart bypass grafting (CABS-BH). Patients (n=100, 86% men, 14% women, age 56-69 years) were divided into 3 groups with comparable sex, age, state of the myocardium, and EUROSCORE surgical risk. In group 1 patients (n=35) we used CABS-CHB, in group 2 (n=32) - CABS-BH-NP, in group 3 (n=33) - CABS-BH. The following parameters were obtained on day 1 after surgery: left ventricular ejection fraction (EF, echocardiography), blood plasma levels of creatine phosphokinase (CPK), CPK-MB, and cardiac troponin I (TnI). There was no significant difference in parameters studied between groups 1 and 2 with a tendency to their more pronounced positive dynamics in group 2. In group 3 compared with groups 1 and 2 we observed significant lowering of levels of CPK (by 21.2-30.9%, p<0.05), CPK-MB (by 9.1-13.1%, p<0.05), TnI (by 0.6-0.7%, p<0.05), and elevation of EF (by 9.8-11.6%, p<0.05). Rate of development of myocardial infarction in group 3 (6.8%) was lower than in groups 1 and 2 (14.2 and 9.8%, respectively). In all groups we observed close correlation between biochemical parameters and left ventricular EF (r=0.74-0.82, p<0.01).
authors.affiliation: Central Clinical Hospital With Polyclinic of the General Management Department of the President of RF, Moscow, Russia.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Kambarov
authors.affiliation: Central Clinical Hospital With Polyclinic of the General Management Department of the President of RF, Moscow, Russia.
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
authors.affiliation: Central Clinical Hospital With Polyclinic of the General Management Department of the President of RF, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Semenyuk
authors.affiliation: Central Clinical Hospital With Polyclinic of the General Management Department of the President of RF, Moscow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Bugrimova
authors.affiliation: Central Clinical Hospital With Polyclinic of the General Management Department of the President of RF, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Ivanov
authors.affiliation: Central Clinical Hospital With Polyclinic of the General Management Department of the President of RF, Moscow, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Velichko
authors.affiliation: Central Clinical Hospital With Polyclinic of the General Management Department of the President of RF, Moscow, Russia.
authors.forename: E E
authors.initials: EE
authors.lastname: Simakov
authors.affiliation: Central Clinical Hospital With Polyclinic of the General Management Department of the President of RF, Moscow, Russia.
authors.forename: M E
authors.initials: ME
authors.lastname: Bilko
authors.affiliation: Central Clinical Hospital With Polyclinic of the General Management Department of the President of RF, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Lushkin