title: The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling.
abstract: Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins. Studies show that ncRNAs are not only involved in cell proliferation, apoptosis, differentiation, metabolism and other physiological processes, but also involved in the pathogenesis of diseases. Cardiac remodeling is the main pathological basis of a variety of cardiovascular diseases. Many studies have shown that the occurrence and development of cardiac remodeling are closely related with the regulation of ncRNAs. Recent research of ncRNAs in heart disease has achieved rapid development. Thus, we summarize here the latest research progress and mainly the molecular mechanism of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), in cardiac remodeling, aiming to look for new targets for heart disease treatment.
authors.affiliation: Center for Developmental Cardiology, Institute for Translational Medicine, Qingdao University, Dengzhou Road 38, Qingdao 266021, China. gjn.1127@163.com.
authors.forename: Jinning
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Basic Medical College, Qingdao University Medical College, Ningxia Road 308, Qingdao 266071, China. qd.wh@163.com.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Xu
authors.affiliation: Center for Developmental Cardiology, Institute for Translational Medicine, Qingdao University, Dengzhou Road 38, Qingdao 266021, China. wangjx@qdu.edu.cn.
authors.forename: Jianxun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Center for Developmental Cardiology, Institute for Translational Medicine, Qingdao University, Dengzhou Road 38, Qingdao 266021, China. wangk696@163.com.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.affiliation: Center for Developmental Cardiology, Institute for Translational Medicine, Qingdao University, Dengzhou Road 38, Qingdao 266021, China. peifli@qdu.edu.cn.
authors.forename: Peifeng
authors.initials: P
authors.lastname: Li
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D012313:RNA / Q000235:genetics* / Q000378:metabolism; D000079962:RNA, Circular; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D020257:Ventricular Remodeling
chemical_list: D035683:MicroRNAs; D000079962:RNA, Circular; D062085:RNA, Long Noncoding; D012313:RNA
keywords: cardiac remodeling; circular RNA; long non-coding RNA; microRNA; non-coding RNA