title: Continuous Aspirin Use Does Not Increase Bleeding Risk of Split-Thickness Skin Transplantation Repair to Chronic Wounds.
abstract: BACKGROUND
  Discontinuation of aspirin therapy before cutaneous surgery may cause serious complications.
  
  
  OBJECTIVE
  The aim of this prospective study was to evaluate the bleeding risk of split-thickness skin transplantation repair to chronic wounds in patients on aspirin therapy.
  
  
  METHODS
  A total of 97 patients who underwent split-thickness skin transplantation surgery of chronic wounds during a 2-year period were enrolled. They were categorized on the basis of aspirin therapies. The primary outcome was postoperative bleeding and bleeding complications. Univariate analysis was performed to examine the association between aspirin and bleeding complications. Among the 26 patients taking aspirin continuously in group A, there were 5 bleeding complications (19.23%). Among the 55 nonusers in group B, there were 10 bleeding complications (18.18%). Among the 16 discontinuous patients in group C, there were 3 bleeding complications (18.75%). No statistical differences were found among the groups ( P = .956). Univariate analysis showed that continuous aspirin use was not significantly associated with bleeding complications (odds ratio, 0.933; 95% confidence interval, 0.283-3.074; P = .910 in the aspirin and control groups) and that discontinuous aspirin use was not significantly associated with bleeding complications (odds ratio, 0.963; 95% confidence interval, 0.230-4.025; P = .959 in the aspirin and control groups; odds ratio, 0.969; 95% confidence interval, 0.198-4.752; P = .969 in the aspirin and discontinuous groups).
  
  
  CONCLUSIONS
  Continuous aspirin use does not produce an additional bleeding risk in patients who undergo split-thickness skin transplantation repair of chronic wounds.
authors.affiliation: 1 Department of Burns & Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.|2 Department of Burns & Plastic Surgery, Central Hospital of Zibo, Zibo, Shandong Province, China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Sun
authors.affiliation: 1 Department of Burns & Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Yibing
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 2 Department of Burns & Plastic Surgery, Central Hospital of Zibo, Zibo, Shandong Province, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: 2 Department of Burns & Plastic Surgery, Central Hospital of Zibo, Zibo, Shandong Province, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: 2 Department of Burns & Plastic Surgery, Central Hospital of Zibo, Zibo, Shandong Province, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.affiliation: 2 Department of Burns & Plastic Surgery, Central Hospital of Zibo, Zibo, Shandong Province, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000453:epidemiology*; D011446:Prospective Studies; D012867:Skin / Q000293:injuries*; D016038:Skin Transplantation / Q000379:methods / Q000706:statistics & numerical data*
chemical_list: D001241:Aspirin
keywords: aspirin; bleeding; chronic wound; skin transplantation