title: Reducing effect of aerobic exercise on blood pressure of essential hypertensive patients: A meta-analysis.
abstract: BACKGROUND
  The comprehensive meta-analysis aimed to explore the reductive effect of aerobic exercise on blood pressure of hypertensive patients.
  
  
  METHODS
  The related researches were selected from PubMed and Embase databases up to June 2016. Based on specific inclusive criteria, the eligible studies were selected, and the heterogeneities in their results were estimated by χ-based Q-test and I statistics. Quantitative meta-analysis was assessed by R 3.12 software, and results were presented by standardized mean difference (SMD) and their 95% confidence intervals (CIs). Outcome indicators were systolic blood pressure (SBP) and diastolic blood pressure (DBP). The publication biases were estimated by Egger test. Besides, the "leave one out" method was used for sensitivity evaluations.
  
  
  RESULTS
  As a result, a total of 13 papers with 802 samples were included. Based on the meta-analysis results, there were no significant differences in SBP and DBP between aerobic and control groups before exercise (SMD = 0.15, 95%CI: -0.16-0.46; SMD = 0.16, 95% CI: -0.23-0.55). However, significant reductions were obviously in aerobic group after aerobics, compared with control (SMD = -0.79, 95% CI: -1.29 to -0.28; SMD = -0.63, 95% CI: -1.14 to -0.12). A significant publication bias was detected in SBP (t = -2.2314, P = 0.04549) but not in DBP (t = -1.4962, P = 0.1604). Additionally, the DBP result would be altered after the exclusion of 2 individual papers.
  
  
  CONCLUSIONS
  Aerobic exercise may be a potential nonpharmacological treatment for blood pressure improvement in essential hypertensive patients.
authors.affiliation: Department of Physical Education, Shanghai University of Finance and Economics School of Physical Education and Sports Training, Shanghai University of Sport, Shanghai, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wen
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
mesh_terms: D001794:Blood Pressure; D015444:Exercise / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000628:therapy*