title: Preparation of a stable aqueous suspension of reduced graphene oxide by a green method for applications in biomaterials.
abstract: A green approach for the preparation of a stable reduced graphene oxide (RGO) suspension from graphene oxide (GO) has been developed. This method uses l-serine (l-Ser) as the reductant and yellow dextrin (YD) as the stabilizing agent. X-ray photoelectron spectroscopy, UV-vis spectroscopy, X-ray diffraction and thermogravimetric analyses showed that l-Ser can efficiently reduce GO at a comparatively low temperature, and that the YD adsorbed onto the RGO facilitating the formation of a stable RGO aqueous suspension. Since l-Ser and YD are natural environmentally friendly materials, this approach provides a green method to produce stable RGO from GO on a large scale. Sodium salicylate (SS) which has an aromatic structure was loaded onto the RGO through π-π interactions and a maximum loading capacity of 44.6mg/g was obtained. The release of the loaded SS can be controlled by adjusting the solution pH, and a 74.8% release was reached after 70h at pH 7.4. The release profile of SS could be further controlled by incorporating it into RGO Dispersed carboxylated chitosan films.
authors.affiliation: Huanhu Hospital, Tianjin 300060, PR China; Tianjin Cerebral Vascular and Neural Degenerative Disease Key Laboratory, Tianjin 300060, PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ji
authors.affiliation: School of Science, Tianjin University, PR China.
authors.forename: Yahui
authors.initials: Y
authors.lastname: Song
authors.affiliation: Huanhu Hospital, Tianjin 300060, PR China; Tianjin Cerebral Vascular and Neural Degenerative Disease Key Laboratory, Tianjin 300060, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.affiliation: Tianjin Medical University, Tianjin 300072, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ge
authors.affiliation: School of Science, Tianjin University, PR China.
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Beijing 302 Hospital, Beijing 300060, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.affiliation: Tianjin First Center Hospital, Tianjin 300192, PR China. Electronic address: yongqiangwang1962@sina.com.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Huanhu Hospital, Tianjin 300060, PR China; Tianjin Cerebral Vascular and Neural Degenerative Disease Key Laboratory, Tianjin 300060, PR China.
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.affiliation: Huanhu Hospital, Tianjin 300060, PR China. Electronic address: qhx@tju.edu.cn.
authors.forename: Haixia
authors.initials: H
authors.lastname: Qiu
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials; D048271:Chitosan / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D055772:Green Chemistry Technology; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D012980:Sodium Salicylate / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D010087:Oxides; D014867:Water; D006108:Graphite; D048271:Chitosan; D012980:Sodium Salicylate
keywords: Graphene oxide; Green method; Sodium salicylate; Stable