title: Cure Rate of Fungal Keratitis With Antibacterial Therapy.
abstract: OBJECTIVE
  To study the cure rate of fungal keratitis with moxifloxacin 0.3% monotherapy.
  
  
  METHODS
  A retrospective review of patients with culture-proven fungal keratitis who initially received moxifloxacin 0.3% monotherapy was performed.
  
  
  RESULTS
  Eleven patients with culture-proven fungal keratitis were initially treated with moxifloxacin. One case each of Curvularia and Alternaria keratitis resolved with moxifloxacin monotherapy (18%).
  
  
  CONCLUSIONS
  Moxifloxacin may have a significant clinical therapeutic effect in a subset of patients with fungal keratitis. Review of the literature in combination with the current study suggests that in patients with clinical features suggestive of fungal keratitis, if rapid diagnostic tests are negative or not available, pending culture results, initial therapy should include a fluoroquinolone (moxifloxacin or gatifloxacin) and/or an aminoglycoside (tobramycin or gentamicin).
authors.affiliation: *Department of Ophthalmology, Baylor College of Medicine, Houston, TX; and †Hollingshead Eye Center, Boise, ID.
authors.forename: Alice Y
authors.initials: AY
authors.lastname: Matoba
authors.forename: Ryan
authors.initials: R
authors.lastname: Barrett
authors.forename: Anna E
authors.initials: AE
authors.lastname: Lehmann
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003320:Corneal Ulcer / Q000188:drug therapy / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D007634:Keratitis / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077266:Moxifloxacin