title: Effect of acetate Ringer's solution with or without 5% dextrose administered intravenously to diarrheic calves.
abstract: The objectives of this study were to evaluate the effects of intravenous acetate Ringer's solution, with or without dextrose, on diarrheic calves with either experimentally induced or spontaneous diarrhea. In the experimental model, diarrhea was induced in nine healthy calves by administering cold milk (below 4°C) twice a day for 2 days. The calves were randomly assigned to the isotonic saline (ISS), acetated Ringer's (AR) or acetated Ringer's with 5% dextrose (ARD) groups, with three calves assigned to each group. The calves received 80 ml/kg of their designated solution, at a flow rate of 20 ml/kg/hr. Infusion of ISS, AR and ARD were all found to be safe and effective in increasing plasma volume. Intravenous (IV) infusion of ISS resulted in the acidification secondary to dilution, while AR and ARD infusion inhibited acidification. In addition, prevention of catabolism was observed only with IV infusion of ARD. Sixteen calves with spontaneous diarrhea were enrolled in the clinical study. The calves were randomly assigned to the AR or ARD groups, with eight calves being assigned to each group. The calves received 100 ml/kg of their designated solution, at a flow rate of 25 ml/kg/hr. Intravenous infusion of AR and ARD was found to be effective in increasing plasma volume and inhibiting acidification. Only infusion of ARD prevented catabolism, but it also led to hyperglycemia. Our results suggest that a solution containing dextrose may be beneficial for wasting diarrheic calves.
authors.affiliation: School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimati, Bunnkyoudai, Ebetsu, Hokkaido 069-8501, Japan.|Donan-NOSAI, Donan Agricultural Mutual Relief Association, 354-1 Oshamannbetyo, Azaoshamannbe, Yamakoshi-gun, Hokkaido 049-3521, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsukano
authors.affiliation: Donan-NOSAI, Donan Agricultural Mutual Relief Association, 25-16 Misugityo, Yakumo, Futami-gun, Hokkaido 049-3114, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Kato
authors.affiliation: Donan-NOSAI, Donan Agricultural Mutual Relief Association, 25-16 Misugityo, Yakumo, Futami-gun, Hokkaido 049-3114, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Sarashina
authors.affiliation: Central Research Laboratories, Nippon Zenyaku Kogyo Co., Ltd., 1-1 Aza Tairanoue, Sasagawa, Asakamachi, Koriyama, Fukushima 963-0196, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Abe
authors.affiliation: Central Research Laboratories, Nippon Zenyaku Kogyo Co., Ltd., 1-1 Aza Tairanoue, Sasagawa, Asakamachi, Koriyama, Fukushima 963-0196, Japan.
authors.forename: Tadaharu
authors.initials: T
authors.lastname: Ajito
authors.affiliation: School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimati, Bunnkyoudai, Ebetsu, Hokkaido 069-8501, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Ohtsuka
authors.affiliation: School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimati, Bunnkyoudai, Ebetsu, Hokkaido 069-8501, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood; D000818:Animals; D000831:Animals, Newborn; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D003967:Diarrhea / Q000188:drug therapy / Q000662:veterinary*; D004359:Drug Therapy, Combination / Q000662:veterinary; D005260:Female; D005947:Glucose / Q000627:therapeutic use*; D007262:Infusions, Intravenous / Q000662:veterinary; D007552:Isotonic Solutions / Q000627:therapeutic use*; D008297:Male
chemical_list: D007552:Isotonic Solutions; C028570:Ringer's acetate; D005947:Glucose; D020155:3-Hydroxybutyric Acid
keywords: acetate Ringer’s solution; beta-hydroxybutyrate; calf; catabolism; diarrhea