title: Are patients with cancer with sepsis and bacteraemia at a higher risk of mortality? A retrospective chart review of patients presenting to a tertiary care centre in Lebanon.
abstract: Most sepsis studies have looked at the general population. The aim of this study is to report on the characteristics, treatment and hospital mortality of patients with cancer diagnosed with sepsis or septic shock.
  
  
  
  A single-centre retrospective study at a tertiary care centre looking at patients with cancer who presented to our tertiary hospital with sepsis, septic shock or bacteraemia between 2010 and 2015.
  
  
  
  176 patients with cancer were compared with 176 cancer-free controls.
  
  
  
  The primary outcome of this study was the in hospital mortality in both cohorts. Secondary outcomes included patient demographics, emergency department (ED) vital signs and parameters of resuscitation along with laboratory work.
  
  
  
  A total of 352 patients were analysed. The mean age at presentation for the cancer group was 65.39±15.04 years, whereas the mean age for the control group was 74.68±14.04 years (p<0.001). In the cancer cohort the respiratory system was the most common site of infection (37.5%) followed by the urinary system (26.7%), while in the cancer-free arm, the urinary system was the most common site of infection (40.9%). intravenous fluid replacement for the first 24 hours was higher in the cancer cohort. ED, intensive care unit and general practice unit length of stay were comparable in both the groups. 95 (54%) patients with cancer died compared with 75 (42.6%) in the cancer-free group. The 28-day hospital mortality in the cancer cohort was 87 (49.4%) vs 46 (26.1%) in the cancer-free cohort (p=0.009). Patients with cancer had a 2.320 (CI 95% 1.225 to 4.395, p=0.010) odds of dying compared with patients without cancer in the setting of sepsis.
  
  
  
  This is the first study looking at an in-depth analysis of sepsis in the specific oncology population. Despite aggressive care, patients with cancer have higher hospital mortality than their cancer-free counterparts while adjusting for all other variables.
authors.affiliation: Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Abou Dagher
authors.affiliation: Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Christopher
authors.initials: C
authors.lastname: El Khuri
authors.affiliation: Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Ahel Al-Hajj
authors.initials: AA
authors.lastname: Chehadeh
authors.affiliation: Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Ali
authors.initials: A
authors.lastname: Chami
authors.affiliation: Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Rana
authors.initials: R
authors.lastname: Bachir
authors.affiliation: Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Dina
authors.initials: D
authors.lastname: Zebian
authors.affiliation: Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Ralphe
authors.initials: R
authors.lastname: Bou Chebl
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000209:etiology / Q000401:mortality*; D003422:Critical Care; D004636:Emergency Service, Hospital; D005260:Female; D005440:Fluid Therapy; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D007861:Lebanon / Q000453:epidemiology; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000401:mortality*; D012141:Respiratory Tract Infections / Q000150:complications; D012189:Retrospective Studies; D018805:Sepsis / Q000150:complications / Q000401:mortality; D062606:Tertiary Care Centers; D014552:Urinary Tract Infections / Q000150:complications
keywords: ACCIDENT & EMERGENCY MEDICINE; INFECTIOUS DISEASES; ONCOLOGY