title: Serum adipocyte fatty acid-binding protein levels are associated with peripheral arterial disease in women, but not men, with type 2 diabetes mellitus.
abstract: BACKGROUND
  Adipocyte fatty acid-binding protein (A-FABP) has been recognized as an important player in macrophage cholesterol trafficking and inflammation, and may promote the development of atherosclerosis. To further elucidate the role of A-FABP in atherosclerosis in diabetes, we investigated the relationship between serum A-FABP concentrations and peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  In all, 488 inpatients with T2DM were enrolled in the study (254 men, 234 women; mean (±SD) age 57.3 ± 13.0 years). The severity of peripheral arterial stenosis was assessed by ultrasound examination. Serum A-FABP concentrations were determined by ELISA.
  
  
  RESULTS
  Serum A-FABP concentrations were significantly higher in patients with than without PAD (8.0 ± 3.3 vs 6.2 ± 1.6 ng/mL, respectively; P < 0.05). Interestingly, there was an obvious gender-related difference in PAD patients with T2DM, with the stenosis rate being higher for female than male T2DM patients in the third A-FABP tertile. Logistic regression analysis revealed that serum A-FABP concentrations were an independent risk factor for PAD in female T2DM patients (odds ratio 1.890, 95% confidence interval 1.041-3.432; P = 0.036), but not in male T2DM patients. Correlation analyses revealed that A-FABP concentrations were correlated with body mass index (BMI), diastolic blood pressure, urinary microalbumin, and serum creatinine in male patients, and with BMI, duration of T2DM, fasting blood glucose, and serum creatinine in female patients.
  
  
  CONCLUSIONS
  Serum A-FABP concentrations are closely associated with PAD in Chinese women with T2DM. The study findings suggest that A-FABP may be a more specific marker of PAD in diabetic women than men.
authors.affiliation: Endocrinology Department, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Min
authors.initials: M
authors.lastname: Ding
authors.affiliation: Endocrinology Department, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Shi
authors.affiliation: Endocrinology Department, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Yun-Zhi
authors.initials: YZ
authors.lastname: Xing
authors.affiliation: Endocrinology Department, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Sun
authors.affiliation: Endocrinology Department, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Qian-Hua
authors.initials: QH
authors.lastname: Fang
authors.affiliation: Endocrinology Department, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Jing-Yun
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: Endocrinology Department, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Qiu-Mei
authors.initials: QM
authors.lastname: Zhang
authors.affiliation: Endocrinology Department, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Chen
authors.affiliation: Endocrinology Department, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: De-Min
authors.initials: DM
authors.lastname: Yu
authors.affiliation: Endocrinology Department, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Chun-Jun
authors.initials: CJ
authors.lastname: Li
mesh_terms: D017667:Adipocytes / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D044466:Asian People; D015415:Biomarkers / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D050556:Fatty Acid-Binding Proteins; D006442:Glycated Hemoglobin; C493410:FABP4 protein, human; C517652:hemoglobin A1c protein, human
keywords: 2型糖尿病; adipocyte; fatty acid binding protein; peripheral arterial disease; type 2 diabetes; 外周动脉疾病; 脂肪细胞; 脂肪酸结合蛋白