title: Implantation potential of mosaic embryos.
abstract: Chromosomal mosaicism is a relatively common finding in human IVF embryos. However, the association between mosaicism in trophoectoderm and inner mass cells, the mechanisms involved, and its effects on implantation are far from established. We retrospectively reanalyzed array-CGH results from 1,362 trophoectoderm biopsies. We detected chromosomal mosaicism in 183 blastocysts (13.4%). A decrease in the clinical pregnancy rate when we compared the cycles where only mosaic embryos were transferred (26.9%) vs. euploid embryos were transferred (40.2%) was not statistically different (p = 0.127). Also a tendency to increase the biochemical miscarriage was reported (21.2% mosaic group vs. 12.3% euploid group; p=0.102). Our data suggests that the transfer of some mosaic embryos achieve full term pregnancies. Additional studies are needed to clarify how embryo mosaicism affects the outcomes of the IVF cycles.
authors.affiliation: a Instituto Bernabeu Biotech , Alicante , Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Lledó
authors.affiliation: a Instituto Bernabeu Biotech , Alicante , Spain.
authors.forename: Ruth
authors.initials: R
authors.lastname: Morales
authors.affiliation: a Instituto Bernabeu Biotech , Alicante , Spain.
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Ortiz
authors.affiliation: a Instituto Bernabeu Biotech , Alicante , Spain.|b Instituto Bernabeu , Alicante , Spain.
authors.forename: Helena
authors.initials: H
authors.lastname: Blanca
authors.affiliation: b Instituto Bernabeu , Alicante , Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Ten
authors.affiliation: b Instituto Bernabeu , Alicante , Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Llácer
authors.affiliation: a Instituto Bernabeu Biotech , Alicante , Spain.|b Instituto Bernabeu , Alicante , Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Bernabeu
mesh_terms: D010064:Embryo Implantation; D005260:Female; D006801:Humans; D008297:Male; D009030:Mosaicism; D011247:Pregnancy; D019836:Preimplantation Diagnosis; D012189:Retrospective Studies
keywords: Comprehensive chromosome screening (CCS); embryo mosaicism; full term pregnancy