title: Serum ferritin as an indicator of the development of encephalopathy in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome.
abstract: OBJECTIVE
  To investigate the diagnostic value of serum ferritin levels as a marker of disease activity and the development of encephalopathy in hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli.
  
  
  METHODS
  Twenty patients with HUS were studied. Serum ferritin levels were compared with clinical features and serum soluble tumor necrosis factor receptor (sTNFR) I and sTNFRII levels. Serum sTNFRI and sTNFRII levels were quantified by enzyme-linked immunosorbent assays.
  
  
  RESULTS
  Serum ferritin levels were significantly elevated at the time of the diagnosis of HUS. Serum ferritin levels were significantly elevated in patients with encephalopathy compared to patients without encephalopathy. HUS patients with serum ferritin levels of >687.5 ng/ml were at high risk of encephalopathy. Serum ferritin levels were significantly positively correlated with serum sTNFRI and sTNFRII levels.
  
  
  CONCLUSIONS
  Serum ferritin levels are a promising indicator of the development of encephalopathy in HUS.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan. shimizum@staff.kanazawa-u.ac.jp.
authors.forename: Masaki
authors.identifier: http://orcid.org/0000-0003-1077-7772
authors.initials: M
authors.lastname: Shimizu
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Inoue
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
authors.forename: Mondo
authors.initials: M
authors.lastname: Kuroda
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Irabu
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Takakura
authors.affiliation: Department of Pediatrics, Komatsu Municipal Hospital, Komatsu, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kaneda
authors.affiliation: Department of Physiology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
authors.forename: Naotoshi
authors.initials: N
authors.lastname: Sugimoto
authors.affiliation: Department of Pediatrics, Kanazawa Medical Center, Kanazawa, Japan.
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Ohta
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yachie
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001927:Brain Diseases / Q000097:blood / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D054324:Enterohemorrhagic Escherichia coli; D004927:Escherichia coli Infections / Q000097:blood / Q000150:complications*; D005260:Female; D005293:Ferritins / Q000097:blood*; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000150:complications* / Q000382:microbiology; D006801:Humans; D007223:Infant; D008297:Male; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D005293:Ferritins
keywords: Encephalopathy; Enterohemorrhagic Escherichia coli; Ferritin; Hemolytic uremic syndrome