title: Phenacyl azides as efficient intermediates: one-pot synthesis of pyrrolidines and imidazoles.
abstract: Phenacyl azides were decomposed in basic media to generate N-unsubstituted imines which were reacted with cyclic amino acids to give an azomethine ylide that underwent [3 + 2] cycloaddition with maleimides and N-unsubstituted imines to yield various diastereoselective pyrrolidines and imidazoles respectively in a one-pot three component manner with good to excellent yields.
authors.affiliation: Department of Medicinal Chemistry and Biotechnology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India. ahmedkamal@iict.res.in ram.cdri@gmail.com.
authors.forename: Chada Narsimha
authors.initials: CN
authors.lastname: Reddy
authors.affiliation: Department of Medicinal Chemistry and Biotechnology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India. ahmedkamal@iict.res.in ram.cdri@gmail.com.
authors.forename: Manda
authors.initials: M
authors.lastname: Sathish
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India.
authors.forename: Susanta
authors.initials: S
authors.lastname: Adhikary
authors.affiliation: Centre for X-Ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India.
authors.forename: Jagadeesh Babu
authors.initials: JB
authors.lastname: Nanubolu
authors.affiliation: Catalytic Chemistry Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Alarifi
authors.affiliation: Applied Organic Chemistry Group, Chemical Science & Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam 785006, India.
authors.forename: Ram Awatar
authors.initials: RA
authors.lastname: Maurya
authors.affiliation: Department of Medicinal Chemistry and Biotechnology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India. ahmedkamal@iict.res.in ram.cdri@gmail.com and Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India and Catalytic Chemistry Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Ahmed
authors.identifier: http://orcid.org/0000-0002-5750-2920
authors.initials: A
authors.lastname: Kamal