title: Matrix Metalloproteases as Biomarkers of Disease.
abstract: Matrix metalloprotease play a vital role in many cellular processes. Dysfunction in activity of these enzymes has been implicated in the pathogenesis of a number of diseases. Factors that affect the balanced interaction between MMPs and their inhibitors, such as genetic mutations of extracellular matrix components or dysregulation of MMP expression, can lead to various diseases. Due to their essential role in ECM remodeling, MMPs have become targets of interest as biomarkers for the diagnosis and prognosis of diseases associated with alterations of the ECM.
authors.affiliation: Departamento de Ciências Biológicas, Instituto de Ciências Químicas, Ambientais e Farmacêuticas, Universidade Federal de São Paulo, Diadema, SP, Brazil. profferfonseca@gmail.com.|Laboratório de Análises Clínicas-Anexo 3, Faculdade de Medicina do ABC, Vila Principe de Gales, n.821, Santo André, SP, 09060-650, Brazil. profferfonseca@gmail.com.
authors.forename: Fernando Luiz Affonso
authors.initials: FL
authors.lastname: Fonseca
authors.affiliation: Laboratório de Análises Clínicas-Anexo 3, Faculdade de Medicina do ABC, Vila Principe de Gales, n.821, Santo André, SP, 09060-650, Brazil.
authors.forename: Beatriz
authors.initials: B
authors.lastname: da Costa Aguiar Alves
authors.affiliation: Departamento de Ciências Biológicas, Instituto de Ciências Químicas, Ambientais e Farmacêuticas, Universidade Federal de São Paulo, Diadema, SP, Brazil.
authors.forename: Ligia Ajaime
authors.initials: LA
authors.lastname: Azzalis
authors.affiliation: Laboratório de Análises Clínicas-Anexo 3, Faculdade de Medicina do ABC, Vila Principe de Gales, n.821, Santo André, SP, 09060-650, Brazil.
authors.forename: Thaís Moura Gáscon
authors.initials: TM
authors.lastname: Belardo
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D004194:Disease / Q000235:genetics*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics* / Q000378:metabolism*; D009154:Mutation; D011379:Prognosis
chemical_list: D015415:Biomarkers; D016326:Extracellular Matrix Proteins; D020782:Matrix Metalloproteinases
keywords: Cancer; Disease; Inflammatory disease; Matrix metalloproteases