title: Driven transport on open filaments with interfilament switching processes.
abstract: We study a two-filament driven lattice gas model with oppositely directed species of particles moving on two parallel filaments with filament-switching processes and particle inflow and outflow at filament ends. The filament-switching process is correlated with the occupation number of the adjacent site such that particles switch filaments with finite probability only when oppositely directed particles meet on the same filament. This model mimics some of the coarse-grained features observed in context of microtubule-(MT) based intracellular transport, wherein cellular cargo loaded and off-loaded at filament ends are transported on multiple parallel MT filaments and can switch between the parallel microtubule filaments. We focus on a regime where the filaments are weakly coupled, such that filament-switching rate of particles scale inversely as the length of the filament. We find that the interplay of (off-) loading processes at the boundaries and the filament-switching process of particles leads to some distinctive features of the system. These features includes occurrence of a variety of phases in the system with inhomogeneous density profiles including localized density shocks, density difference across the filaments, and bidirectional current flows in the system. We analyze the system by developing a mean field (MF) theory and comparing the results obtained from the MF theory with the Monte Carlo (MC) simulations of the dynamics of the system. We find that the steady-state density and current profiles of particles and the phase diagram obtained within the MF picture matches quite well with MC simulation results. These findings maybe useful for studying multifilament intracellular transport.
authors.affiliation: Institute of Physics, Sachivalaya Marg, Bhubaneswar 751005, India.|Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400085, India.
authors.forename: Subhadip
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Departament de Fisica de la Matèria Condensada, Universitat de Barcelona, C. Marti i Franques 1, 08028 Barcelona, Spain.|UBICS, Universitat de Barcelona Institute of Complex Systems, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Pagonabarraga
authors.affiliation: Institute of Physics, Sachivalaya Marg, Bhubaneswar 751005, India.|Department of Physics, Savitribai Phule Pune University, Ganeshkhind, Pune 411007, India.
authors.forename: Sudipto
authors.initials: S
authors.lastname: Muhuri
mesh_terms: D001692:Biological Transport; D003198:Computer Simulation; D008870:Microtubules / Q000378:metabolism*; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism; D009010:Monte Carlo Method
chemical_list: D020409:Molecular Motor Proteins