title: Carbapenem-Resistant Enterobacteriaceae: A Strategic Roadmap for Infection Control.
abstract: The incidence of carbapenem-resistant Enterobacteriaceae (CRE) has increased worldwide with great regional variability. Infections caused by these organisms are associated with crude mortality rates of up to 70%. The spread of CRE in healthcare settings is both an important medical problem and a major global public health threat. All countries are at risk of falling victim to the emergence of CRE; therefore, a preparedness plan is required to avoid the catastrophic natural course of this epidemic. Proactive and adequate preventive measures locally, regionally, and nationally are required to contain the spread of these bacteria. The keys to success in preventing the establishment of CRE endemicity in a region are early detection through targeted laboratory protocols and containment of spread through comprehensive infection control measures. This guideline provides a strategic roadmap for infection control measures based on the best available evidence and expert opinion, to enable preparation of a multifaceted preparedness plan to abort epidemics of CRE. Infect Control Hosp Epidemiol 2017;38:580-594.
authors.affiliation: 1Barwon Health,Victoria,Australia.
authors.forename: N Deborah
authors.initials: ND
authors.lastname: Friedman
authors.affiliation: 2Tel Aviv Sourasky Medical Center,Tel Aviv,Israel.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Carmeli
authors.affiliation: 1Barwon Health,Victoria,Australia.
authors.forename: Aaron Lea
authors.initials: AL
authors.lastname: Walton
authors.affiliation: 3National Center for Infection Control,Israel Ministry of Health,Tel Aviv,Israel.
authors.forename: Mitchell James
authors.initials: MJ
authors.lastname: Schwaber
mesh_terms: D015780:Carbapenems / Q000494:pharmacology; D003428:Cross Infection / Q000382:microbiology / Q000517:prevention & control*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D017408:Guidelines as Topic; D006801:Humans; D017053:Infection Control / Q000379:methods*; D018571:Sentinel Surveillance
chemical_list: D015780:Carbapenems