title: HER2 testing in gastric cancer: results of a German expert meeting.
abstract: Valid HER2 testing is essential for optimal therapy of patients with HER2-positive gastric cancer and the correct use of first-line chemotherapy. While testing for HER2 status in breast cancer is routinely performed, this is not the case for HER2 testing in gastric cancer and it is usually only performed on clinician request. An interdisciplinary German expert group (pathologists and clinicians) took the challenges of HER2 testing in gastric cancer as an opportunity to address essential aspects and questions for the practical use of HER2 testing in this indication. The recommendations made in this manuscript reflect the consensus of all participants and reflect their opinions and long-term experience in this field.
authors.affiliation: Universitätsklinikum Leipzig, Universitäres Krebszentrum (UCCL), Liebigstraße 20, 04103, Leipzig, Germany. florian.lordick@medizin.uni-leipzig.de.
authors.forename: Florian
authors.identifier: http://orcid.org/0000-0001-8591-9339
authors.initials: F
authors.lastname: Lordick
authors.affiliation: UCT University Cancer Center Frankfurt, Frankfurt am Main, Germany.
authors.forename: Salah-Eddin
authors.initials: SE
authors.lastname: Al-Batran
authors.affiliation: Institut für Pathologie, Charité Universitätsmedizin Berlin Campus Mitte, Berlin, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Dietel
authors.affiliation: Pathologisches Institut der Universitätsmedizin Mannheim, Mannheim, Germany.
authors.forename: Timo
authors.initials: T
authors.lastname: Gaiser
authors.affiliation: Universitätsmedizin Mannheim, Mannheim, Germany.
authors.forename: Ralf-Dieter
authors.initials: RD
authors.lastname: Hofheinz
authors.affiliation: Pathologisches Institut der Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kirchner
authors.affiliation: Institut für Pathologie, Medizinische Hochschule Hannover, Hanover, Germany.
authors.forename: Hans H
authors.initials: HH
authors.lastname: Kreipe
authors.affiliation: Medizinische Klinik des Klinikums rechts der Isar, Munich, Germany.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Lorenzen
authors.affiliation: Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Möhler
authors.affiliation: Institut für Pathologie, Uniklinik Köln, Cologne, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Quaas
authors.affiliation: Institut für Pathologie Christian-Albrechts-Universität, Kiel, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Röcken
authors.affiliation: Institut für Pathologie Nordhessen u. Targos GmbH, Kassel, Germany.
authors.forename: Josef
authors.initials: J
authors.lastname: Rüschoff
authors.affiliation: Georgius Agricola Stiftung Ruhr, Institut für Pathologie der Ruhr-Universität Bochum am Berufsgenossenschaftlichen Universitätsklinikum, Bochum, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Tannapfel
authors.affiliation: Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Thuss-Patience
authors.affiliation: Institut für Pathologie, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Baretton
mesh_terms: D032921:Consensus; D006801:Humans; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D013274:Stomach Neoplasms / Q000201:enzymology*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human
keywords: Consensus; Gastric cancer; HER2 testing; Quality assurance; Trastuzumab