title: Memory and depressive effect on male and female Swiss mice exposed to tannery effluent.
abstract: Although tannery industries generate substantial profits to the countries they are located in, they work with one of the most environmentally harmful human activities. Tannery effluents (TE) are highly toxic; thus, their improper release into water bodies may cause severe problems to individuals depending on this water. Therefore, the aim of the current study is to assess the effects of oral exposure to TE on the anxiety-, memory deficit- and depression-predictive behaviors in male and female Swiss adult mice. The following experimental groups were set in order to do so, control, positive control (reference drugs) and effluent. The animals in the effluent group were treated with 5% TE diluted in potable water for 15 consecutive days. The neurobehavioral tests started on the 12th experimental day. The results found through the elevated plus-maze test (for anxiety prediction) showed no anxiogenic or anxiolytic effects on animals exposed to TE. On the other hand, animals treated with TE showed short- and long-term memory deficit in the object recognition test, as well as depression-predictive behavior in the forced swimming test. These results may concern the high concentration of heavy metals and neurotoxic organic compounds in the TE. Therefore, the oral exposure to TE, even for a short period-of-time, has effects on the central nervous system (CNS) that lead to neurobehavioral changes. Thus, the current study broadens the knowledge on this research field by demonstrating the neurotoxicity of xenobiotics to male and female Swiss mice.
authors.affiliation: Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil, Post-Graduation Program in Conservation of Cerrado Natural Resources, Biological Research Laboratory, Goiano Federal Institute - Urutaí Campus, GO, Brazil; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil. Biological Research Laboratory, Goiano Federal Institute - Urutaí Campos, GO, Brazil.
authors.forename: Abraão Tiago Batista
authors.initials: ATB
authors.lastname: Guimarães
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil. Biological Research Laboratory, Goiano Federal Institute - Urutaí Campos, GO, Brazil.
authors.forename: Raíssa
authors.initials: R
authors.lastname: de Oliveira Ferreira
authors.affiliation: Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil. Biological Research Laboratory, Goiano Federal Institute - Urutaí Campos, GO, Brazil; Departamento de Ciências Biológicas, Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano - Campus Urutaí, GO, Brazil. Biological Sciences Department, Post-Graduation Program in Conservation of Cerrado Natural Resources, Goiano Federal Institute - Urutaí Campus, GO, Brazil.
authors.forename: Aline Sueli
authors.initials: AS
authors.lastname: de Lima Rodrigues
authors.affiliation: Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil, Post-Graduation Program in Conservation of Cerrado Natural Resources, Biological Research Laboratory, Goiano Federal Institute - Urutaí Campus, GO, Brazil; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil. Biological Research Laboratory, Goiano Federal Institute - Urutaí Campos, GO, Brazil; Departamento de Ciências Biológicas, Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano - Campus Urutaí, GO, Brazil. Biological Sciences Department, Post-Graduation Program in Conservation of Cerrado Natural Resources, Goiano Federal Institute - Urutaí Campus, GO, Brazil; Programa de Pós-Graduação em Biodiversidade Animal, Universidade Federal de Goiás - Campus Samambaia, Goiânia, GO, Brazil. Post-Graduation Program in Animal Biodiversity, Federal University of Goiás - Samambaia Campus, Goiânia, GO, Brazil. Electronic address: guilhermeifgoiano@gmail.com.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Malafaia
mesh_terms: D000818:Animals; D001007:Anxiety / Q000139:chemically induced; D001522:Behavior, Animal / Q000187:drug effects; D003863:Depression / Q000139:chemically induced*; D005260:Female; D007220:Industrial Waste / Q000009:adverse effects*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D051379:Mice
chemical_list: D007220:Industrial Waste
keywords: Agro-industrial waste; Experimental models; Tannery industries; Xenobiotics