title: A Head-to-Head Comparison of UK SF-6D and Thai and UK EQ-5D-5L Value Sets in Thai Patients with Chronic Diseases.
abstract: OBJECTIVE
  Little was known about the head-to-head comparison of psychometric properties between SF-6D and EQ-5D-5L or the different value sets of EQ-5D-5L. Therefore, this study set out to compare the psychometric properties including agreement, convergent, and known-group validity between the SF-6D and the EQ-5D-5L using the real value sets from Thailand and the UK in patients with chronic diseases.
  
  
  METHODS
  356 adults taking a medication for at least 3 months were identified from a university hospital in Bangkok, Thailand, between July 2014 and March 2015. Agreement was assessed by intraclass correlation coefficients (ICCs) and Bland-Altman plots. Convergent validity was evaluated using Spearman's rank correlation coefficients between SF-6D and EQ-5D-5L and EQ-VAS and SF-12v2. For known-groups validity, the Mann-Whitney U test and Kruskal-Wallis test were used to examine the associations between SF-6D and EQ-5D-5L and patient characteristics.
  
  
  RESULTS
  Agreements between the SF-6D and the EQ-5D-5L using Thai and UK value sets were fair, with ICCs of 0.45 and 0.49, respectively. Bland-Altman plots showed that the majority of the SF-6D index scores were lower than the EQ-5D-5L index scores. Both the EQ-5D-5L value sets were more related to the EQ-VAS and physical health, while the SF-6D was more associated with mental health. Both EQ-5D-5L value sets were more sensitive than the SF-6D in discriminating patients with different levels of more known groups except for adverse drug reactions.
  
  
  CONCLUSIONS
  The SF-6D and both EQ-5D-5L value sets appeared to be valid but sensitive to different outcomes in Thai patients with chronic diseases.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand. phantipa.s@pharm.chula.ac.th.
authors.forename: Phantipa
authors.initials: P
authors.lastname: Sakthong
authors.affiliation: Pharmacy Unit, Phramongkutklao Hospital, Bangkok, Thailand.
authors.forename: Wipaporn
authors.initials: W
authors.lastname: Munpan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000523:psychology*; D002908:Chronic Disease / Q000188:drug therapy* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055553:Prescription Drugs / Q000627:therapeutic use*; D011594:Psychometrics / Q000379:methods*; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D013785:Thailand; D006113:United Kingdom; D044465:White People / Q000523:psychology*; D055815:Young Adult
chemical_list: D055553:Prescription Drugs
keywords: Discrete Choice Experiment; Health Utility; Index Score; Mental Component Summary; Physical Component Summary