title: Comparison of myocardial damage among dogs at different stages of clinical leishmaniasis and dogs with idiopathic chronic kidney disease.
abstract: Canine leishmaniasis (CanL) is a systemic disease caused by the protozoan parasite Leishmania infantum. Myocarditis in CanL has been described previously in CanL by histopathological analysis of post-mortem specimens and by evaluation of cardiac troponin I (cTnI) levels. However, the degree of myocardial damage at different stages of CanL and the role that concurrent azotaemia plays in this myocardial injury are unknown. The aim of this study was to prospectively evaluate and compare the presence of myocardial injury in dogs at different stages of clinical CanL and in dogs with severe idiopathic chronic kidney disease (CKD) by measuring cTnI. Forty-eight dogs were included in the study, divided into four groups: (1) group A (10 healthy dogs); (2) group B (17 dogs with CanL without renal azotaemia, classified as mild to severe in the LeishVet scheme); (3) group C (11 dogs with CanL and renal azotaemia, classified as very severe in the LeishVet scheme); and (4) group D (10 dogs with idiopathic CKD). Dogs in group C had significantly higher cTnI than dogs in groups B and D, although cTnI was also elevated in these groups. Dogs in group A had normal cTnI values. Dogs in groups D and C had similar renal IRIS classification scorers. Severe lymphoplasmocytic myocarditis and a positive real time PCR of L. infantum DNA were observed in all dogs in group C. Dogs with very severe CanL exhibit more myocardial injury than dogs with milder CanL or dogs with idiopathic CKD.
authors.affiliation: Faculty of Veterinary Sciences, University of Extremadura, Avenida de la Universidad s/n, Cáceres 10003, Spain. Electronic address: L.Martinez-Hernandez@liverpool.ac.uk.
authors.forename: L
authors.initials: L
authors.lastname: Martínez-Hernández
authors.affiliation: Langford Cardiology Service, Small Animal Hospital, Langford Veterinary Services, University of Bristol, Bristol BS40 5DU, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: Casamian-Sorrosal
authors.affiliation: Faculty of Veterinary Sciences, University of Extremadura, Avenida de la Universidad s/n, Cáceres 10003, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Barrera-Chacón
authors.affiliation: Faculty of Veterinary Sciences, University of Extremadura, Avenida de la Universidad s/n, Cáceres 10003, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Cuesta-Gerveno
authors.affiliation: Faculty of Veterinary Sciences, University of Extremadura, Avenida de la Universidad s/n, Cáceres 10003, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Belinchón-Lorenzo
authors.affiliation: Faculty of Veterinary Sciences, University of Extremadura, Avenida de la Universidad s/n, Cáceres 10003, Spain.
authors.forename: L C
authors.initials: LC
authors.lastname: Gómez Nieto
authors.affiliation: Faculty of Veterinary Sciences, University of Extremadura, Avenida de la Universidad s/n, Cáceres 10003, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Duque-Carrasco
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000469:parasitology / Q000473:pathology*; D004285:Dogs; D005260:Female; D006321:Heart / Q000469:parasitology; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009205:Myocarditis / Q000209:etiology / Q000469:parasitology / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D019210:Troponin I / Q000097:blood
chemical_list: D019210:Troponin I
keywords: Canine; Cardiac troponin I; Leishmaniasis; Myocardial damage