title: Clinical and molecular epidemiology of Acinetobacter baumannii bloodstream infections in an endemic setting.
abstract: The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata.
  
  
  
  Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly analyzed at a single center, at least one transmission opportunity was evident for 85% of patients. This implies that patient-to-patient transmission is the major mode of A. baumannii acquisitions in health facilities. Moreover, all patients who died immediately (<24 h of admission) were infected with a single clone (ST457; relative risk = 1.6; p = 0.05).
  
  
  
  This preliminary analysis should prompt further investigation by mapping genomic virulence determinants among A. baumannii ST457 lineage compared with other strains.
authors.affiliation: Unit of Infectious Diseases, Assaf Harofeh Medical Center, Zerifin, Israel.|Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Dror
authors.initials: D
authors.lastname: Marchaim
authors.affiliation: Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Dana
authors.initials: D
authors.lastname: Levit
authors.affiliation: Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Roy
authors.initials: R
authors.lastname: Zigron
authors.affiliation: NIBN, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Gordon
authors.affiliation: Clinical Microbiology Laboratory, Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: Tsillia
authors.initials: T
authors.lastname: Lazarovitch
authors.affiliation: Instituto de Microbiologia & Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
authors.forename: Joao A
authors.initials: JA
authors.lastname: Carrico
authors.affiliation: NIBN, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Vered
authors.initials: V
authors.lastname: Chalifa-Caspi
authors.affiliation: Public Health Services, Ministry of Health, Jerusalem, Israel.|Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.|ESCMID Study Group for Genomic & Molecular Diagnostics (ESGMD), Basel, Switzerland.
authors.forename: Jacob
authors.initials: J
authors.lastname: Moran-Gilad
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology* / Q000401:mortality / Q000635:transmission; D040981:Acinetobacter baumannii / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000382:microbiology* / Q000401:mortality / Q000635:transmission; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D010802:Phylogeny; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D001426:Bacterial Proteins
keywords: Gram-negative; MDR; MLST; carbapenem; nonfermenter; nosocomial infections; typing