title: New insights into protein secretion: TANGO1 runs rings around the COPII coat.
abstract: In this issue, Liu et al. (2017.J. Cell Biol.https://doi.org/10.1083/jcb.201611088) and Raote et al. (2017.J. Cell Biol.https://doi.org/10.1083/jcb.201608080) use super-resolution microscopy to visualize large COPII-coated endoplasmic reticulum (ER) export carriers. Rings of TANGO1 surround COPII, implicating TANGO1 in organizing ER exit sites and in regulating COPII coat dynamics and geometry.
authors.affiliation: Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637 bsglick@uchicago.edu.
authors.forename: Benjamin S
authors.identifier: 0000-0002-7921-1374
authors.initials: BS
authors.lastname: Glick
mesh_terms: D000818:Animals; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000378:metabolism*; D022181:COP-Coated Vesicles / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000502:physiology; D006056:Golgi Apparatus / Q000378:metabolism / Q000502:physiology; D021381:Protein Transport / Q000502:physiology*; D033921:Vesicular Transport Proteins / Q000378:metabolism
chemical_list: D033921:Vesicular Transport Proteins; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator