title: Antimicrobial Activity of ε-Poly-l-lysine after Forming a Water-Insoluble Complex with an Anionic Surfactant.
abstract: ε-Poly-l-lysine (ε-PL) is one of the few homopoly(amino-acid)s occurring in nature. ε-PL, which possesses multiple amino groups, is highly soluble in water, where it forms the antimicrobial polycationic chain (PLn+). Although the high water-solubility is advantageous for the use of ε-PL as a food preservative, it has limited the applicability of ε-PL as a biopolymer plastic. Here, we report on the preparation and availability of a water-insoluble complex formed with PLn+and an anionic surfactant, bis(2-ethylhexyl) sulfosuccinate (BEHS-, is also commercialized as AOT) anion. The PLn+/BEHS--complex, which is soluble in organic solvents, was successfully used as a coating material for a cellulose acetate membrane to create a water-resistant antimicrobial membrane. In addition, the thermoplastic PLn+/BEHS--complex was able to be uniformly mixed with polypropylene by heating, resulting in materials exhibiting antimicrobial activities.
authors.affiliation: Department of Bioscience, Fukui Prefectural University , 4-1-1 Matsuoka-Kenjojima, Eiheiji-cho, Yoshida-gun, Fukui 910-1195, Japan.
authors.forename: Kazunori
authors.identifier: 0000-0002-9229-6018
authors.initials: K
authors.lastname: Ushimaru
authors.affiliation: Department of Bioscience, Fukui Prefectural University , 4-1-1 Matsuoka-Kenjojima, Eiheiji-cho, Yoshida-gun, Fukui 910-1195, Japan.
authors.forename: Yoshimitsu
authors.identifier: 0000-0001-5117-5116
authors.initials: Y
authors.lastname: Hamano
authors.affiliation: Department of Bioscience, Fukui Prefectural University , 4-1-1 Matsuoka-Kenjojima, Eiheiji-cho, Yoshida-gun, Fukui 910-1195, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Katano
mesh_terms: D000838:Anions; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000187:drug effects; D006358:Hot Temperature; D008567:Membranes, Artificial; D011107:Polylysine / Q000737:chemistry* / Q000494:pharmacology; D011126:Polypropylenes / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects; D013386:Succinates / Q000737:chemistry* / Q000494:pharmacology; D013501:Surface-Active Agents / Q000737:chemistry* / Q000494:pharmacology; D044366:Transition Temperature
chemical_list: D000838:Anions; D000890:Anti-Infective Agents; D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D011126:Polypropylenes; D013386:Succinates; D013501:Surface-Active Agents; C511925:bis(2-ethylhexyl)sulfosuccinate; D011107:Polylysine