title: Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions.
abstract: The reaction between benzyl amines, triethyl orthoformate, and diethyl phosphite affords either bisphosphonic (compound1) orN-benzylaminobenzylphosphonic (compound2) acid depending on the reaction conditions. The final output of the reaction can be manipulated by the choice of reaction conditions, particularly the molar ratio of substrates.
authors.affiliation: Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, 50-370 Wrocław, Poland. patrycja.miszczyk@pwr.edu.pl.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Miszczyk
authors.affiliation: The Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland. ilona.turowska-tyrk@pwr.edu.pl.
authors.forename: Ilona
authors.initials: I
authors.lastname: Turowska-Tyrk
authors.affiliation: Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, 50-370 Wrocław, Poland. pawel.kafarski@pwr.edu.pl.
authors.forename: Paweł
authors.initials: P
authors.lastname: Kafarski
authors.affiliation: Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, 50-370 Wrocław, Poland. ewa.chmielewska@pwr.edu.pl.
authors.forename: Ewa
authors.initials: E
authors.lastname: Chmielewska
mesh_terms: D001596:Benzylamines / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D018360:Crystallography, X-Ray; D004164:Diphosphonates / Q000138:chemical synthesis*; D005561:Formates / Q000737:chemistry*; D008958:Models, Molecular; D063065:Organophosphonates / Q000138:chemical synthesis*; D017905:Phosphites / Q000737:chemistry*
chemical_list: D001596:Benzylamines; D004164:Diphosphonates; D005561:Formates; D063065:Organophosphonates; D017905:Phosphites; C472310:alpha-benzylaminobenzylphosphonic acid
keywords: N-benzylaminobenzylphosphonates; N-benzylaminomethylenebisphosphonic acid; aminophosphonates; bisphosphonates; multicomponent reactions; synthesis of C-P bond