title: ZnO-Nanorods as an Efficient Heterogeneous Catalyst for the Synthesis of Thiazole Derivatives in Water.
abstract: Aims & Scope: Thiazole derivatives are produced using one-pot multicomponent reactions of acid chlorides, potassium thiocyanate, amino acids, alkyl bromides and ZnO nanorods (NR-ZnO) as the catalyst in water at ambient temperature. These reactions were no't performed without using NR-ZnO as the catalyst. Nanorods of ZnO have been prepared by reflux procedure using sodium dodecylsulfate (SDS). Nanorods of ZnO showed a considerable improvement in the yield of the product and displayed significant reusable activity.
  
  
  METHODS
  In these reactions, all chemicals were prepared from Fluka (Buchs, Switzerland). Nanorods of ZnO were synthesized in the laboratory according to literature report. By using an electrothermal 9100 apparatus, melting points of synthesized compounds were determined. Heraeus CHN-O-Rapid analyzer was employed for elemental analyses for C, H, and N. FINNIGANMAT 8430 spectrometer operating at an ionization potential of 70 eV was used for mass spectra. Shimadzu IR-460 spectrometer was employed for IR spectra. BRUKER DRX-500 AVANCE spectrometer at 500.1 and 125.8 MHz was used for 1H, and 13C NMR spectra for solutions in CDCl3 with TMS as internal standard or 85% H3PO4 as external standard, respectively.
  
  
  RESULTS
  We describe a facile and green synthetic method for the synthesis of thiazole derivatives 5 from acid chlorides, potassium thiocyanate, alkyl bromides and amino acids using NR-ZnO- as the catalyst in water at room temperature.
  
  
  CONCLUSIONS
  In conclusion, we describe an efficient, green procedure and high yielding synthesis of thiazole derivatives using acid chlorides, potassium thiocyanate, alkyl bromides and amino acids in the presence of NR-ZnO as the catalyst in water at room temperature.
authors.affiliation: Department of Chemistry, Ferdowsi University of Mashhad, Mashhad. Iran.
authors.forename: Sayyed Jalal
authors.initials: SJ
authors.lastname: Shams-Najafi
authors.affiliation: Department of Chemistry, Ferdowsi University of Mashhad, Mashhad. Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Gholizadeh
authors.affiliation: Department of Chemistry, Ferdowsi University of Mashhad, Mashhad. Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Ahmadpour
authors.affiliation: Department of Chemistry, Faculty of Science, Gonbad Kavous University, P.O. Box 163, Gonbad. Iran.
authors.forename: Faramarz
authors.initials: F
authors.lastname: Rostami-Charati
mesh_terms: D002384:Catalysis; D055772:Green Chemistry Technology / Q000379:methods; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013861:Thiocyanates / Q000737:chemistry; D014867:Water / Q000737:chemistry; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D013844:Thiazoles; D013861:Thiocyanates; D014867:Water; D015034:Zinc Oxide; C009941:potassium thiocyanate
keywords: Alkyl bromides; ZnO nanorod; acid chloride; multicomponent reactions; potassium thiocyanate