title: Two new sesquiterpene lactone glycosides from Cnicus benedictus.
abstract: Two new sesquiterpene lactone glycosides, namely melitensin 15-O-β-D-glucoside (1) and 11β,13-dihydrosalonitenolide 15-O-β-D-glucoside (2), along with eight known compounds (3-10) were isolated from the aerial part of Cnicus benedictus L. Their structures were elucidated from analyses of extensive spectroscopic data. Compounds 1-6 all possessed an α-methyl-γ-lactone moiety. Moreover, compound 5 exhibited moderate activity against the growth of Aspergillus fumigatus, with IC50values of 17.67 μg mL-1.
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.|b National Center for Natural Products Research, Division of Pharmacognosy, Department of BioMolecular Sciences , School of Pharmacy, University of Mississippi , University , MS , USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Peng
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Jian
authors.affiliation: b National Center for Natural Products Research, Division of Pharmacognosy, Department of BioMolecular Sciences , School of Pharmacy, University of Mississippi , University , MS , USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Zulfiqar
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.|b National Center for Natural Products Research, Division of Pharmacognosy, Department of BioMolecular Sciences , School of Pharmacy, University of Mississippi , University , MS , USA.
authors.forename: Kaiqiang
authors.initials: K
authors.lastname: Zhang
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.|b National Center for Natural Products Research, Division of Pharmacognosy, Department of BioMolecular Sciences , School of Pharmacy, University of Mississippi , University , MS , USA.
authors.forename: Fei
authors.initials: F
authors.lastname: Long
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.
authors.forename: Caiyun
authors.initials: C
authors.lastname: Peng
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Cai
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.|b National Center for Natural Products Research, Division of Pharmacognosy, Department of BioMolecular Sciences , School of Pharmacy, University of Mississippi , University , MS , USA.
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
authors.affiliation: a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D031179:Centaurea; D031181:Cnicus / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D006027:Glycosides; D007783:Lactones; D012717:Sesquiterpenes
keywords: Asteraceae; Cnicus benedictus; antimicrobial; sesquiterpene lactone glycosides