title: The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study.
abstract: The adipocytokines and insulin-like growth factor 1 (IGF-1) are involved in insulin resistance, the cardiometabolic syndrome, and atherosclerosis. Therefore, investigating the relationship between circulating levels of the novel adipocytokines and IGF-1 is worthwhile. The correlation between IGF-1, visfatin, and omentin-1 has not been adequately investigated. In a population-based study, 324 postmenopausal women were randomly selected. Circulating IGF-1, visfatin, omentin-1, adiponectin, and high-sensitivity C-reactive protein (hs-CRP) levels were measured with the highly specific enzyme-linked immunosorbent assay method. In multiple regression analyses adjusted for alkaline phosphatase, osteocalcin, and hs-CRP, circulating IGF-1 was significantly correlated with visfatin levels (standardized β coefficient [β] = 0.13, partial correlation coefficient [r] = 0.12, p = 0.028). The significant positive correlation between serum IGF-1 and visfatin levels remained after additional adjustments for age and BMI (β = 0.12, r = 0.12, p = 0.025), metabolic syndrome (β = 0.13, r = 0.12, p = 0.021), and type 2 diabetes mellitus (β = 0.13, r = 0.12, p = 0.026). No significant correlations were found between IGF-1, adiponectin, and omentin-1. There is a significant correlation between serum IGF-1 and visfatin levels in postmenopausal women beyond metabolic syndrome, type 2 diabetes, bone formation markers, and hs-CRP levels. The observed correlation between higher circulating IGF-1 and the higher visfatin levels might be a physiological compensation and adaptation to protect against visfatin-induced proinflammatory effects.
authors.affiliation: a Department of Endocrine Disorders, The Persian Gulf Tropical Medicine Research Centre , The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Darabi
authors.affiliation: a Department of Endocrine Disorders, The Persian Gulf Tropical Medicine Research Centre , The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: Afshin
authors.initials: A
authors.lastname: Ostovar
authors.affiliation: a Department of Endocrine Disorders, The Persian Gulf Tropical Medicine Research Centre , The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Raeisi
authors.affiliation: a Department of Endocrine Disorders, The Persian Gulf Tropical Medicine Research Centre , The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Kalantarhormozi
authors.affiliation: b The Persian Gulf Nuclear Medicine Research Centre, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Assadi
authors.affiliation: a Department of Endocrine Disorders, The Persian Gulf Tropical Medicine Research Centre , The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: Samad
authors.initials: S
authors.lastname: Akbarzadeh
authors.affiliation: c Department of Biochemistry, The Persian Gulf Marine Biotechnology Research Centre , The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: Safieh
authors.initials: S
authors.lastname: Momeni
authors.affiliation: c Department of Biochemistry, The Persian Gulf Marine Biotechnology Research Centre , The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: Sina
authors.initials: S
authors.lastname: Dobaradaran
authors.affiliation: a Department of Endocrine Disorders, The Persian Gulf Tropical Medicine Research Centre , The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: Katayoun
authors.initials: K
authors.lastname: Vahdat
authors.affiliation: a Department of Endocrine Disorders, The Persian Gulf Tropical Medicine Research Centre , The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences , Bushehr , Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Nabipour
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D058851:GPI-Linked Proteins / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D037102:Lectins / Q000378:metabolism*; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism*; D017698:Postmenopause / Q000378:metabolism*
chemical_list: D052242:Adiponectin; D016207:Cytokines; D058851:GPI-Linked Proteins; C583557:IGF1 protein, human; C432397:ITLN1 protein, human; D037102:Lectins; D007334:Insulin-Like Growth Factor I; D054409:Nicotinamide Phosphoribosyltransferase
keywords: Adipocytokine; adiponectin; insulin-like growth factor 1; omentin-1; visfatin