title: A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible.
abstract: Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Delineating the margins of the disease was impossible at presentation given her OLP, and she was initially treated with concurrent chemoradiation therapy. She then developed a recurrence of the mandibular alveolar ridge. The patient was successfully treated with a composite resection including a segmental mandibulectomy, buccal mucosa resection, partial glossectomy, and ipsilateral neck dissection. This was reconstructed with a free fibula osteo-septo-cutaneous flap. Mandibular OSCC is a rare complication of OLP with few reports on effective reconstructive interventions. The case represents the youngest reported patient with mandibular OSCC arising in the context of OLP and highlights the utility of the free vascularized fibula graft in the treatment of these patients.
authors.affiliation: Duke University School of Medicine, Duke University Medical Center, Durham, N.C.; Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, N.C.; Department of Pathology, Duke University Medical Center, Durham, N.C.; and Division of Otolaryngology - Head and Neck Surgery, Duke University Medical Center, Durham, N.C.
authors.forename: Joanne
authors.initials: J
authors.lastname: Soo
authors.affiliation: Duke University School of Medicine, Duke University Medical Center, Durham, N.C.; Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, N.C.; Department of Pathology, Duke University Medical Center, Durham, N.C.; and Division of Otolaryngology - Head and Neck Surgery, Duke University Medical Center, Durham, N.C.
authors.forename: George
authors.initials: G
authors.lastname: Kokosis
authors.affiliation: Duke University School of Medicine, Duke University Medical Center, Durham, N.C.; Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, N.C.; Department of Pathology, Duke University Medical Center, Durham, N.C.; and Division of Otolaryngology - Head and Neck Surgery, Duke University Medical Center, Durham, N.C.
authors.forename: Michael
authors.initials: M
authors.lastname: Ogilvie
authors.affiliation: Duke University School of Medicine, Duke University Medical Center, Durham, N.C.; Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, N.C.; Department of Pathology, Duke University Medical Center, Durham, N.C.; and Division of Otolaryngology - Head and Neck Surgery, Duke University Medical Center, Durham, N.C.
authors.forename: Xiaoyin
authors.initials: X
authors.lastname: Sara Jiang
authors.affiliation: Duke University School of Medicine, Duke University Medical Center, Durham, N.C.; Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, N.C.; Department of Pathology, Duke University Medical Center, Durham, N.C.; and Division of Otolaryngology - Head and Neck Surgery, Duke University Medical Center, Durham, N.C.
authors.forename: David B
authors.initials: DB
authors.lastname: Powers
authors.affiliation: Duke University School of Medicine, Duke University Medical Center, Durham, N.C.; Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, N.C.; Department of Pathology, Duke University Medical Center, Durham, N.C.; and Division of Otolaryngology - Head and Neck Surgery, Duke University Medical Center, Durham, N.C.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Rocke
authors.affiliation: Duke University School of Medicine, Duke University Medical Center, Durham, N.C.; Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, N.C.; Department of Pathology, Duke University Medical Center, Durham, N.C.; and Division of Otolaryngology - Head and Neck Surgery, Duke University Medical Center, Durham, N.C.
authors.forename: Detlev
authors.initials: D
authors.lastname: Erdmann