title: Antimicrobial Metabolites from Streptomyces sp. SN0280.
abstract: One new indole derivative, chloroindole (1), one new diketone, streptoone A (2), two new ketonic acids, streptoones B (3) and C (4), and one known macrolide antibiotic, X-14952B (5), were isolated from Streptomyces sp. SN0280. Extensive NMR, HRESIMS, and IR analysis was used to elucidate their structures. Streptoone A (2) displayed antibacterial activity (MIC value of 7.81 μg/mL) against Clavibater michiganensis, comparable with the positive control streptomycin (MIC value of 7.81 μg/mL). Streptoone B (3) showed antifungal activity (MIC value of 15.63 μg/mL) against Phytophthora capsici (positive control carbendazol MIC value of 7.81 μg/mL). These molecules provide new templates for the potential treatment and management of these phytopathogens.
authors.affiliation: College of Plant Protection, Shenyang Agricultural University , Shenyang 110866, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Tian
authors.affiliation: College of Plant Protection, Shenyang Agricultural University , Shenyang 110866, People's Republic of China.
authors.forename: Jamil
authors.initials: J
authors.lastname: Shafi
authors.affiliation: College of Plant Protection, Shenyang Agricultural University , Shenyang 110866, People's Republic of China.|Engineering & Technological Research Center of Biopesticide for Liaoning Province , Shenyang 110866, People's Republic of China.
authors.forename: Mingshan
authors.initials: M
authors.lastname: Ji
authors.affiliation: College of Plant Protection, Shenyang Agricultural University , Shenyang 110866, People's Republic of China.
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Bi
authors.affiliation: College of Plant Protection, Shenyang Agricultural University , Shenyang 110866, People's Republic of China.|Engineering & Technological Research Center of Biopesticide for Liaoning Province , Shenyang 110866, People's Republic of China.
authors.forename: Zhiguo
authors.identifier: 0000-0002-0909-6788
authors.initials: Z
authors.lastname: Yu
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000378:metabolism; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry; D001562:Benzimidazoles / Q000494:pharmacology; D002219:Carbamates / Q000494:pharmacology; D002681:China; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018942:Macrolides / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010838:Phytophthora / Q000187:drug effects; D012988:Soil Microbiology; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D001562:Benzimidazoles; D002219:Carbamates; D007211:Indoles; D018942:Macrolides; C046082:antibiotic X 14952B; C006698:carbendazim