title: [Type of Thrombolytic Agent and Rate of Acute Kidney Injury in Patients With Myocardial Infarction].
abstract: Aim of this study was to assess incidence and severity of acute kidney injury (AKI) in patients with ST-elevation (STE) myocardial infarction (MI) after thrombolytic therapy with alteplase or streptokinase. Among 292 included patients (227 men, 65 women, mean age 58+/-11 years) 170 received streptokinase, 122 - alteplase. Coronary angiography in acute stage of MI was an exclusion criterion. Thrombolysis was effective in 213 (73%) patients. There was no statistically significant difference in effectiveness of thrombolysis among streptokinase or alteplase treated patients. Incidence of AKI in patients with STEMI was 25%. Both incidence and severity of AKI were higher in streptokinase treated patients. Only stage II-III AKI was significantly associated with higher in-hospital mortality.
authors.affiliation: Department of Internal Medicine, Ulyanovsk State University, ul. Architect Livchaka, 2/1, 432063 Ulyanovsk, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Menzorov
authors.affiliation: Department of Internal Medicine, Ulyanovsk State University, ul. Architect Livchaka, 2/1, 432063 Ulyanovsk, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Shutov
authors.affiliation: Department of Internal Medicine, Ulyanovsk State University, ul. Architect Livchaka, 2/1, 432063 Ulyanovsk, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Serov
authors.affiliation: Department of Internal Medicine, Ulyanovsk State University, ul. Architect Livchaka, 2/1, 432063 Ulyanovsk, Russia.
authors.forename: Y V
authors.initials: YV
authors.lastname: Saenko
authors.affiliation: Department of Internal Medicine, Ulyanovsk State University, ul. Architect Livchaka, 2/1, 432063 Ulyanovsk, Russia.
authors.forename: I Y
authors.initials: IY
authors.lastname: Grishenkin