title: Chemical leukoderma induced by dimethyl sulfate.
abstract: Chemical leukoderma occurs due to the toxic effect of a variety of chemical agents. Mechanisms include either destruction or inhibition of melanocytes. We report two male patients (36 and 51 years old) who presented with multiple hypopigmented macules and patches on the neck, wrist, and legs after exposure to dimethyl sulfate in a chemical industry. Physical examination revealed irregular depigmentation macules with sharp edges and clear hyperpigmentation around the lesions. History of repeated exposure to a chemical agent can help the clinical diagnosis of chemical leukoderma. This diagnosis is very important for prognosis and therapeutic management of the disease.
authors.affiliation: Hospital of Nanjing Medical University, Nanjing - Jiangsu, China.
authors.forename: Maya Valeska
authors.initials: MV
authors.lastname: Gozali
authors.affiliation: Hospital of Nanjing Medical University, Nanjing - Jiangsu, China.
authors.forename: Jia-An
authors.initials: JA
authors.lastname: Zhang
authors.affiliation: Hospital of Nanjing Medical University, Nanjing - Jiangsu, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yi
authors.affiliation: Hospital of Nanjing Medical University, Nanjing - Jiangsu, China.
authors.forename: Bing-Rong
authors.initials: BR
authors.lastname: Zhou
authors.affiliation: Hospital of Nanjing Medical University, Nanjing - Jiangsu, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Luo
mesh_terms: D000328:Adult; D009783:Dermatitis, Occupational / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced / Q000473:pathology; D017496:Hypopigmentation / Q000139:chemically induced* / Q000473:pathology*; D008297:Male; D008544:Melanocytes / Q000187:drug effects / Q000473:pathology; D008875:Middle Aged; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013463:Sulfuric Acid Esters / Q000633:toxicity*
chemical_list: D013463:Sulfuric Acid Esters; C007482:dimethyl sulfate