title: [Breast cancer in Morocco: phenotypic profile of tumors].
abstract: Breast cancer is most common in women and it is among the leading causes of cancer related deaths. The curability of this type of tumor is increasing thanks to screening programs and treatment advances which have certainly enhanced patient survival. But challenges remain, particularly in respect of phenotypic instability of cancer cells. The aim of this study was to analyse the phenotypic profile of breast cancer in patients treated at Mohammed VI Cancer Treatment Center over the years 2013-2014. We conducted a cross-sectional study over a two-year period, including the cases of breast cancer treated in our Center. Data were collected from patients medical records and analyzed using Epi Info software. 1277 patients were treated in our Center. 99.5% were females, mean age 50.20 ± 11.34 years. The most common histological type was invasive ductal carcinoma (80.7% of cases). It was diagnosed at an early stage (56,9%). The most common molecular phenotype was luminal A (41.4% of cases). Luminal B, HER2 and triple negatives occurred in 10.4%, 6.3%, 11.2% of cases respectively. The study of tumor phenotype in patients with breast cancer helps clinician make treatment choice and policy makers implement programs against this disease.
authors.affiliation: Laboratoire de Physiopathologie et Génétique Moléculaire, Faculté des Sciences Ben M'Sik, Université Hassan II, Casablanca, Maroc.
authors.forename: Ahmadaye Ibrahim
authors.initials: AI
authors.lastname: Khalil
authors.affiliation: Registre des Cancers de la Région du Grand Casablanca, Maroc.
authors.forename: Karima
authors.initials: K
authors.lastname: Bendahhou
authors.affiliation: Laboratoire de Physiopathologie et Génétique Moléculaire, Faculté des Sciences Ben M'Sik, Université Hassan II, Casablanca, Maroc.
authors.forename: Houriya
authors.initials: H
authors.lastname: Mestaghanmi
authors.affiliation: Laboratoire de Biologie et Santé, Unité de Recherche Associée au CNRST-URAC 34, Faculté des Sciences Ben M'Sik, Université Hassan II, Casablanca, Maroc.
authors.forename: Rachid
authors.initials: R
authors.lastname: Saile
authors.affiliation: Centre Mohammed VI pour le traitement des cancers, CHU Ibn Rochd Casablanca, Maroc.
authors.forename: Abdellatif
authors.initials: A
authors.lastname: Benider
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D018567:Breast Neoplasms, Male / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009018:Morocco / Q000453:epidemiology; D009367:Neoplasm Staging; D010641:Phenotype; D055815:Young Adult
keywords: Breast cancer; immunohistochemistry; phenotype; prognosis