title: Renal infarct volume and renal function decline in acute and chronic phases.
abstract: BACKGROUND
  Acute renal infarction (ARI) is a rare disease. ARI causes decline in renal function in both the acute and chronic phases. However, the correlation between the volume of the infarction and degree of renal function decline has not been fully investigated. Therefore, we aimed to examine the relationship between the volume of the infarction and degree of renal function decline.
  
  
  METHODS
  We performed a single-center, retrospective, observational study investigating clinical parameters and the volume of the infarction. The volume of the infarction was measured using reconstructed computed tomography data.
  
  
  RESULTS
  A total of 39 patients (mean age, 72.6 ± 13.2 years; men, 59%) were enrolled. The median infarction volume was 45 mL (interquartile range, 14-91 mL). The volume of the infarction was significantly associated with the peak lactate dehydrogenase (LDH) level (median, 728 IU/L; interquartile range, 491-1227 U/L) (r = 0.58, p < 0.01) and the degree of renal function decline in both acute and chronic phases (r = -0.44, -0.38, respectively, p < 0.05). The peak LDH level was significantly correlated with the degree of renal function decline in the acute phase but not in the chronic phase (r = -0.35, -0.21; p < 0.05, N.S., respectively).
  
  
  CONCLUSIONS
  The volume of the infarction may be a factor in the degree of renal function decline in ARI. Therefore, assessment of infarct volume in ARI is important.
authors.affiliation: Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichisita Hebita Ishinomaki, Miyagi, 986-8522, Japan.
authors.forename: Saeko
authors.initials: S
authors.lastname: Kagaya
authors.affiliation: Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichisita Hebita Ishinomaki, Miyagi, 986-8522, Japan.
authors.forename: Ojima
authors.initials: O
authors.lastname: Yoshie
authors.affiliation: Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichisita Hebita Ishinomaki, Miyagi, 986-8522, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Fukami
authors.affiliation: Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichisita Hebita Ishinomaki, Miyagi, 986-8522, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sato
authors.affiliation: Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichisita Hebita Ishinomaki, Miyagi, 986-8522, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Saito
authors.affiliation: Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichisita Hebita Ishinomaki, Miyagi, 986-8522, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Takeuchi
authors.affiliation: Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichisita Hebita Ishinomaki, Miyagi, 986-8522, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Matsuda
authors.affiliation: Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichisita Hebita Ishinomaki, Miyagi, 986-8522, Japan. tasukunagasawa0903@gmail.com.
authors.forename: Tasuku
authors.identifier: http://orcid.org/0000-0002-2012-1171
authors.initials: T
authors.lastname: Nagasawa
mesh_terms: D058186:Acute Kidney Injury / Q000473:pathology* / Q000503:physiopathology; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007238:Infarction / Q000473:pathology* / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
keywords: 3-Dimensional reconstructed computed tomography; Acute kidney injury; Acute renal infarction; Atrial fibrillation; Chronic kidney disease