title: A curated collection of tissue microarray images and clinical outcome data of prostate cancer patients.
abstract: Microscopy image data of human cancers provide detailed phenotypes of spatially and morphologically intact tissues at single-cell resolution, thus complementing large-scale molecular analyses, e.g., next generation sequencing or proteomic profiling. Here we describe a high-resolution tissue microarray (TMA) image dataset from a cohort of 71 prostate tissue samples, which was hybridized with bright-field dual colour chromogenic and silver in situ hybridization probes for the tumour suppressor gene PTEN. These tissue samples were digitized and supplemented with expert annotations, clinical information, statistical models of PTEN genetic status, and computer source codes. For validation, we constructed an additional TMA dataset for 424 prostate tissues, hybridized with FISH probes for PTEN, and performed survival analysis on a subset of 339 radical prostatectomy specimens with overall, disease-specific and recurrence-free survival (maximum 167 months). For application, we further produced 6,036 image patches derived from two whole slides. Our curated collection of prostate cancer data sets provides reuse potential for both biomedical and computational studies.
authors.affiliation: Department of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: Qing
authors.identifier: 0000-0002-5340-301X
authors.initials: Q
authors.lastname: Zhong
authors.affiliation: Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.
authors.forename: Tiannan
authors.identifier: 0000-0003-3869-7651
authors.initials: T
authors.lastname: Guo
authors.affiliation: Department of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Rechsteiner
authors.affiliation: Department of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: Jan H
authors.initials: JH
authors.lastname: Rüschoff
authors.affiliation: Department of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: Niels
authors.initials: N
authors.lastname: Rupp
authors.affiliation: Department of Urology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Fankhauser
authors.affiliation: Department of Urology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: Karim
authors.initials: K
authors.lastname: Saba
authors.affiliation: Department of Urology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: Ashkan
authors.initials: A
authors.lastname: Mortezavi
authors.affiliation: Department of Urology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: Cédric
authors.initials: C
authors.lastname: Poyet
authors.affiliation: Department of Urology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hermanns
authors.affiliation: Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: Holger
authors.initials: H
authors.lastname: Moch
authors.affiliation: Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.|Faculty of Science, University of Zurich, 8057 Zurich, Switzerland.
authors.forename: Ruedi
authors.initials: R
authors.lastname: Aebersold
authors.affiliation: Department of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.|University of Zurich, 8006 Zurich, Switzerland.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Wild
mesh_terms: D020869:Gene Expression Profiling; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008297:Male; D051059:PTEN Phosphohydrolase / Q000235:genetics; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000601:surgery; D040901:Proteomics
chemical_list: D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human