title: Efficient reporting of the estimated glomerular filtration rate without height in pediatric patients with cancer.
abstract: BACKGROUND
  The updated bedside Schwartz equation requires constant, serum creatinine concentration and height measurements to calculate the estimated glomerular filtration rate (eGFR) in pediatric patients. Unlike the serum creatinine levels, obtaining height information from the laboratory information system (LIS) is not always possible in a clinical laboratory. Recently, the height-independent eGFR equation, the full age spectrum (FAS) equation, has been introduced. We evaluated the performance of height-independent eGFR equation in Korean children with cancer.
  
  
  METHODS
  A total of 250 children who underwent chromium-51-ethylenediamine tetra acetic-acid (51Cr-EDTA)-based glomerular filtration rate (GFR) measurements were enrolled. The 51Cr-EDTA GFR was used as the reference GFR. The bias (eGFR - measured GFR), precision (root mean square error [RMSE]) and accuracy (P30) of the FAS equations were compared to those of the updated Schwartz equation. P30 was defined as the percentage of patients whose eGFR was within ±30% of the measured GFR.
  
  
  RESULTS
  The FAS equation showed significantly lower bias (mL/min/1.73 m2) than the updated Schwartz equation (4.2 vs. 8.7, p<0.001). The RMSE and P30 were: updated Schwartz of 43.8 and 64.4%, respectively, and FAS of 42.7 and 66.8%, respectively.
  
  
  CONCLUSIONS
  The height-independent eGFR-FAS equation was less biased and as accurate as the updated Schwartz equation in Korean children. The use of the height-independent eGFR equation will allow for efficient reporting of eGFR through the LIS in clinical laboratories.
authors.affiliation: .
authors.forename: Tae-Dong
authors.initials: TD
authors.lastname: Jeong
authors.affiliation: .
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Cho
authors.affiliation: .
authors.forename: Woochang
authors.initials: W
authors.lastname: Lee
authors.affiliation: .
authors.forename: Sail
authors.initials: S
authors.lastname: Chun
authors.affiliation: .
authors.forename: Ki-Sook
authors.initials: KS
authors.lastname: Hong
authors.affiliation: .
authors.forename: Won-Ki
authors.initials: WK
authors.lastname: Min
mesh_terms: D000293:Adolescent; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis*; D012189:Retrospective Studies
chemical_list: D003404:Creatinine
keywords: children; creatinine; glomerular filtration rate; height; laboratory information system