title: Intracellular calcium release channels: an update.
abstract: Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) are calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we summarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca2+release channels in the regulation of mitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus.
authors.affiliation: The Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA.|Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
authors.forename: Gaetano
authors.identifier: 0000-0001-7231-375X
authors.initials: G
authors.lastname: Santulli
authors.affiliation: The Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA.|Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Nakashima
authors.affiliation: The Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA.|Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Yuan
authors.affiliation: The Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA.|Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.|Department of Medicine, Columbia University, New York, NY, USA.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Marks
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002118:Calcium / Q000378:metabolism / Q000502:physiology; D003920:Diabetes Mellitus / Q000378:metabolism; D006321:Heart / Q000502:physiology; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D019837:Ryanodine Receptor Calcium Release Channel / Q000502:physiology*
chemical_list: D053496:Inositol 1,4,5-Trisphosphate Receptors; D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium
keywords: Calcium; Diabetes mellitus; Heart failure; Hypertension; IP3R; Intracellular calcium release channels; RyR; excitation-contraction coupling