title: [Serological and nutritional outcome of infants born to HIV positive mothers undergoing option B + therapy in Guédiawaye].
abstract: As part of its Plan to eliminate mother-to-child transmission of HIV, Senegal has adopted, since 2012, WHO's B + option, which consists of systematic triple therapy for HIV-positive pregnant women associated with breastfeeding and antiretroviral (ARV) prophylaxis for their infants. Our study aims to analyze the risks of mother-to-child transmission of HIV and the nutritional outcome of infants undergoing B + option.
  
  
  METHODS
  We conducted a descriptive, retrospective study at the King Baudouin health center in Guédiaway from 1 September 2012 to 30 April 2015. All infants whose mothers were on triple therapy, undergoing protected breastfeeding, ARV prophylaxis and serological test at 14th months were included in the study. The parameters studied were mother's age and serological profile, father's serological status, the sharing of the status within the couple, infant nourishing, infant ARV prophylaxis, nutritional status at 6 and 12 months and serological status of the infant at 14 months. Out of the 126 infants undergoing PMTCT program, 42 or 33.33% of infants following the B + guidelines were included in the study. The age of mothers ranged from 15 to 42 years, with an average age of 31 years. The majority of mothers (88.1%) carried type 1 virus and 11.9% carried type 2 virus; 20 couples (47.62%) were sero-concordant, 14 were serodifferent, while the serological status was unknown or not investigated in 8 fathers (19.05%). A significant difference between fathers' serological profile and the sharing status (p <0.05) was found. The majority of infants (88.1%) were born at term via vaginal delivery (95.2%), with an average birth weight of 2880 grams. In relation to prophylaxis, the majority of infants received prophylactic monotherapy, 27 (64.28%) received NVP, 4 (9.52%) received AZT, while 11 (26.19%) received triple combination of AZT + 3TC + NVP. The AME was effective in 80.9% of infants and weaning began at 12 months in 80.9% of infants. In relation to nutritional status, at 6 months 12% and 7.1% of infants had MAM and MAS respectively. At 12 months, 19.1% of infants had MAM. Retroviral serology was negative in all the 42 infants at 14 months. B + option is an effective strategy to reduce the MTCT rate. However, early malnutrition in children requires nutritional support for breastfeeding mothers as well as a good psychosocial support.
authors.affiliation: Centre Hospitalier Roi Baudouin de Guédiawaye, Dakar, Sénégal.
authors.forename: Diouf Jean
authors.initials: DJ
authors.lastname: Baptiste
authors.affiliation: Clinique Gynécologique et Obstétricale, Hôpital Aristide Le Dantec Dakar. Avenue Pasteur, BP: 3001 Dakar, Sénégal.
authors.forename: Diallo
authors.initials: D
authors.lastname: Djibril
authors.affiliation: Université Cheikh Anta Diop de Dakar Sénégal.
authors.forename: Sylla
authors.initials: S
authors.lastname: Assane
authors.affiliation: ONG Synergie pour l'enfance, Cité Lobatt Fall Pikine, BP: 20330 Thiaroye.
authors.forename: Mbaye
authors.initials: M
authors.lastname: Ngagne
authors.affiliation: ONG Synergie pour l'enfance, Cité Lobatt Fall Pikine, BP: 20330 Thiaroye.
authors.forename: Ouattara
authors.initials: O
authors.lastname: Baly
authors.affiliation: Université Cheikh Anta Diop de Dakar Sénégal.
authors.forename: Ndiaye
authors.initials: N
authors.lastname: Ousmane
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001942:Breast Feeding; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D007228:Infant Nutrition Disorders / Q000453:epidemiology; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008297:Male; D009035:Mothers; D018529:Nutritional Support / Q000379:methods; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000821:virology; D012189:Retrospective Studies; D012675:Senegal; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents
keywords: HIV; PMTCT; nutrition; option B +