title: Micro-emultocrit technique: A valuable tool for determination of critical HLB value of emulsions.
abstract: The aim of this work was to develop a methodology for rapid determination of the critical hydrophilic-lipophilic balance (HLB) value of lipophilic fractions of emulsions. The emulsions were prepared by the spontaneous emulsification process with HLB value from 4.3 to 16.7. The preparations were stored at 2 different temperatures (25°C and 4°C) and their physicochemical behavior was evaluated by the micro-emultocrit technique and the long-term stability study. The experimental data show a reverse relationship between HLB values of the surfactant mixtures and emulsion stability. A close correlation between the results for both stability procedures was observed, suggesting the use of micro-emultocrit to predict stabilities of such systems. In addition, it was found that the critical HLB of the Mygliol 812 was 15.367.
authors.affiliation: Departmento de Farmácia-Programa de Pós Graduação em Ciências da Saúde-Laboratório de Sistemas Dispersos (LASID), Universidade Federal do Rio Grande do Norte, Rua Praia de Areia Branca 8948, 59094-450, Natal-RN, Brazil.
authors.forename: Janus P F
authors.initials: JP
authors.lastname: Macedo
authors.affiliation: Departmento de Farmácia-Programa de Pós Graduação em Ciências da Saúde-Laboratório de Sistemas Dispersos (LASID), Universidade Federal do Rio Grande do Norte, Rua Praia de Areia Branca 8948, 59094-450, Natal-RN, Brazil.
authors.forename: Leonardo L
authors.initials: LL
authors.lastname: Fernandes
authors.affiliation: Departmento de Farmácia-Programa de Pós Graduação em Ciências da Saúde-Laboratório de Sistemas Dispersos (LASID), Universidade Federal do Rio Grande do Norte, Rua Praia de Areia Branca 8948, 59094-450, Natal-RN, Brazil.
authors.forename: Fábio R
authors.initials: FR
authors.lastname: Formiga
authors.affiliation: Departmento de Farmácia-Programa de Pós Graduação em Ciências da Saúde-Laboratório de Sistemas Dispersos (LASID), Universidade Federal do Rio Grande do Norte, Rua Praia de Areia Branca 8948, 59094-450, Natal-RN, Brazil.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Reis
authors.affiliation: Departmento de Farmácia-Programa de Pós Graduação em Ciências da Saúde-Laboratório de Sistemas Dispersos (LASID), Universidade Federal do Rio Grande do Norte, Rua Praia de Areia Branca 8948, 59094-450, Natal-RN, Brazil.
authors.forename: Toshiyuiky
authors.initials: T
authors.lastname: Nagashima Júnior
authors.affiliation: Departmento de Farmácia-Programa de Pós Graduação em Ciências da Saúde-Laboratório de Sistemas Dispersos (LASID), Universidade Federal do Rio Grande do Norte, Rua Praia de Areia Branca 8948, 59094-450, Natal-RN, Brazil.
authors.forename: Luiz A L
authors.initials: LA
authors.lastname: Soares
authors.affiliation: Departmento de Farmácia-Programa de Pós Graduação em Ciências da Saúde-Laboratório de Sistemas Dispersos (LASID), Universidade Federal do Rio Grande do Norte, Rua Praia de Areia Branca 8948, 59094-450, Natal-RN, Brazil. socrates@digi.com.br.
authors.forename: E Socrates T
authors.initials: ES
authors.lastname: Egito
keywords: creaming index; emulsions; hydrophilic-lipophilic balance; micro-emultocrit; spontaneous emulsification process; stability