title: Optimization of a Modified QuEChERS Method for Multiresidue Analysis of Pharmaceuticals and Personal Care Products in Sewage and Surface Water by LC-MS/MS.
abstract: A quick, sensitive multiresidue method was developed for the analysis of 19 multiclass pharmaceuticals and personal care products (PPCPs) in surface water and sewage water. The proposed modified QuEChERS method involved the extraction of water samples (10 mL) with acetonitrile (10 mL) after the addition of 1% acetic acid, 4 g magnesium sulfate, and 0.2 g ammonium acetate, and was validated in distilled water, surface water, and sewage water with respect to linearity, LOD and LOQ, precision, and accuracy. The LOD and LOQ varied within the ranges of 0.001-0.167 and 0.002-0.25 ng/mL, respectively. Recoveries of the target compounds ranged from 73 to 125%, with precision RSD values <27%. The method provided a precise estimation of PPCPs in field samples, and acetaminophen, atenolol, metformin, sulfamethoxazole, carbamazepine, methylparaben, and triclosan were detected in concentrations ranging from 0.10 to 1.40 and 0.10 to 3.4 ng/mL in surface water and sewage water, respectively. This is an innovative application of the QuEChERS approach for estimation of PPCPs from aqueous matrixes. The method provides significantly higher output (preparation of 25-30 samples a day) compared to conventional SPE-based methods (<10 samples a day).
authors.affiliation: Council of Scientific and Industrial Research-National Environmental Engineering Research Institute, Water Technology and Management Division, Nehru Nagar, Nagpur 440 020, Maharashtra, India.
authors.forename: Akanksha S
authors.initials: AS
authors.lastname: Kachhawaha
authors.affiliation: Council of Scientific and Industrial Research-National Environmental Engineering Research Institute, Water Technology and Management Division, Nehru Nagar, Nagpur 440 020, Maharashtra, India.
authors.forename: Pranav M
authors.initials: PM
authors.lastname: Nagarnaik
authors.affiliation: Indian Council of Agricultural Research, National Research Centre for Grapes, National Referral Laboratory, Pune 412 307, Maharashtra, India.
authors.forename: Manjusha
authors.initials: M
authors.lastname: Jadhav
authors.affiliation: Indian Council of Agricultural Research, National Research Centre for Grapes, National referral Laboratory, Pune 412 307, Maharashtra, India.
authors.forename: Anjali
authors.initials: A
authors.lastname: Pudale
authors.affiliation: Council of Scientific and Industrial Research-National Environmental Engineering Research Institute, Water Technology and Management Division, Nehru Nagar, Nagpur 440 020, Maharashtra, India.
authors.forename: Pawan K
authors.initials: PK
authors.lastname: Labhasetwar
authors.affiliation: Indian Council of Agricultural Research, National Research Centre for Grapes, National Referral Laboratory, Pune 412 307, Maharashtra, India.
authors.forename: Kaushik
authors.initials: K
authors.lastname: Banerjee
mesh_terms: D002853:Chromatography, Liquid; D003358:Cosmetics / Q000032:analysis*; D004350:Drug Residues / Q000032:analysis*; D012722:Sewage / Q000032:analysis*; D053719:Tandem Mass Spectrometry; D014867:Water / Q000032:analysis*; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D003358:Cosmetics; D012722:Sewage; D014874:Water Pollutants, Chemical; D014867:Water