abstract: Due to intrathecal application, CSE combines rapid response with adequate analgesia with the possibility of providing unlimited neuraxial obstetrical pain relief via the indwelling epidural catheter. The superiority of CSE over EDA lies above all in its rapid action, excellent analgesia, lack of motor blockade after a single intrathecal opioid administration, lower rate of unilateral blockages and less need for subsequent epidural injections. The most common side effect is pruritus, which is harmless and usually does not require any therapeutic intervention. Even if no effect on rate of C-sections and APGAR values have been observed, the increased rate of fetal bradycardia after CSE must be kept in mind. A reduction of these fetal bradycardias and after intrathecal administration, prolongation of analgesia by means of appropriate drug combinations or additives should be the subject of future research.
authors.forename: Jan
authors.initials: J
authors.lastname: Wallenborn
authors.forename: Thorsten
authors.initials: T
authors.lastname: Artmann
authors.forename: Peter
authors.initials: P
authors.lastname: Kranke
mesh_terms: D015360:Analgesia, Epidural / Q000009:adverse effects / Q000379:methods*; D016362:Analgesia, Obstetrical / Q000009:adverse effects / Q000379:methods*; D000775:Anesthesia, Spinal / Q000009:adverse effects / Q000379:methods*; D001919:Bradycardia / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D003131:Combined Modality Therapy / Q000009:adverse effects / Q000379:methods; D019317:Evidence-Based Medicine; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D048949:Labor Pain / Q000175:diagnosis* / Q000628:therapy*; D010147:Pain Measurement / Q000187:drug effects; D011247:Pregnancy; D011537:Pruritus / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome