title: Sepsis Mimicker in an Human Immunodeficiency Virus-Infected Patient.
abstract: A 22-year-old human immunodeficiency virus-infected male presented with fever, rash, hypotension, and renal insufficiency 18 days following initiation of therapy with an efavirenz-based antiretroviral regimen. Although rash is a common side effect of efavirenz, severe hypersensitivity reactions are rare. Systemic symptoms can include hepatic toxicity and pneumonitis, and in one instance death. Corticosteroids are the mainstay of treatment.
authors.affiliation: Department of Infectious Disease, Walter Reed National Military Medical Center, 8960 Brown Drive, Bethesda, MD 20889.
authors.forename: Mackenzie K
authors.initials: MK
authors.lastname: Morgan
authors.affiliation: Department of Infectious Disease, Walter Reed National Military Medical Center, 8960 Brown Drive, Bethesda, MD 20889.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Hartzell
authors.affiliation: Department of Infectious Disease, Walter Reed National Military Medical Center, 8960 Brown Drive, Bethesda, MD 20889.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Blaylock
mesh_terms: D000480:Alkynes; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D044966:Anti-Retroviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D048588:Benzoxazines / Q000494:pharmacology / Q000627:therapeutic use; D003521:Cyclopropanes; D063926:Drug Hypersensitivity Syndrome / Q000150:complications / Q000175:diagnosis*; D005076:Exanthema / Q000209:etiology; D005334:Fever / Q000209:etiology; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis*; D015497:HIV-1 / Q000472:pathogenicity; D006801:Humans; D008297:Male; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000068698:Tenofovir / Q000494:pharmacology / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000209:etiology; D055815:Young Adult
chemical_list: D000480:Alkynes; D000900:Anti-Bacterial Agents; D044966:Anti-Retroviral Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D018894:Reverse Transcriptase Inhibitors; D000068698:Tenofovir; C098320:efavirenz