title: On the role of the connective tissue in the patterning of the chick limb musculature.
abstract: By modifying the temporal relationship between connective tissue and myogenic cell invasion during early limb bud development new evidence of the organizing role of the connective tissue was obtained.Muscle cell-deprived wing buds were allowed to grow up to stages 22 to 27 of Hamburger and Hamilton, when they received a transplant of quail myogenic cells (somitic mesoderm or wing premuscular mass) into the dorsal face of their presumptive upper arm. Muscular arrangement in forearm and hand was analyzed 4 days later. In 8 out of 14 of those cases which had received a graft of premuscular mass before stage 25 of Hamburger and Hamilton, muscle development took place distally to the graft-site in accordance with the wing segment.
authors.affiliation: Equipe de recherche associée au CNRS no 621, Morphogenèse expérimentale, Laboratoire de Zoologie et Biologie animale, Université scientifique et médicale de Grenoble, F-38041, Grenoble, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Chevallier
authors.affiliation: Equipe de recherche associée au CNRS no 621, Morphogenèse expérimentale, Laboratoire de Zoologie et Biologie animale, Université scientifique et médicale de Grenoble, F-38041, Grenoble, France.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Kieny
keywords: Chick and quail embryos; Connective tissue; Limb bud musculature Myogenic cells