title: Pyridinium-Substituted TetraphenylethyleneEntailing Alkyne Moiety: Enhancement of Photosensitizing Efficiency and Antimicrobial Activity.
abstract: Apart from sensing and imaging, luminogens with aggregation-induced emission (AIE) are also interesting for photosensitizing. The photosensitizing behavior and bacteria-killing performance of a pyridinium-substituted tetraphenylethylene with an alkyne group (TPE-A-Py+) is reported herein. Interestingly, TPE-A-Py+exhibits higher photosensitizing efficiency than TPE-Py+(without alkyne group) when I-was used as a counteranion. This is well explained by the fact that the ΔΕSTbetween the excited singlet state (S1) and triplet state (T1) was lower for TPE-A-Py+than for TPE-Py+, according to theoretical calculations. Moreover, replacement of I-with other anions (PF6-, N(SO2CF3)2-and BPh4-) led to a decrease of photosensitizing efficiency for TPE-A-Py+. Notably, TPE-A-Py+could be used as an efficient photosensitizer to photo-inactivate ampicillin-resistant (ampr) E. coli at low concentration under white-light irradiation very quickly.
authors.affiliation: CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.|University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: You
authors.affiliation: Key Laboratory of Organic OptoElectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Huili
authors.initials: H
authors.lastname: Ma
authors.affiliation: CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.|University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Yuancheng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.
authors.forename: Guanxin
authors.initials: G
authors.lastname: Zhang
authors.affiliation: CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Peng
authors.affiliation: CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.
authors.forename: Libing
authors.initials: L
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.|University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.|University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Deqing
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000480:Alkynes / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000480:Alkynes; D000900:Anti-Bacterial Agents; D017319:Photosensitizing Agents; D011726:Pyridinium Compounds
keywords: aggregation-induced emission; fluorescent probes; photodynamic therapy; singlet oxygen; tetraphenylethylene