title: Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting.
abstract: It has been shown that inflammation and oxidative stress are important factors in postoperative atrial fibrillation (POAF). Angiotensin converting enzyme (ACE) and apelin have a close relationship with inflammation and oxidative stress. The effect of ACE and apelin on POAF after off-pump coronary artery bypass grafting (OPCABG) remains a question. The concentrations of serum ACE, angiotensin II (Ang II), apelin, bradykinin (BK), malondialdehyde (MDA), and C reactive protein (CRP) were measured in the perioperative period of OPCABG. The levels of serum ACE in the POAF group were higher than in the no POAF group both preoperatively and postoperatively. Apelin in the POAF group was lower than in the no POAF group. There was a correlation between serum ACE and apelin. Postoperatively, CRP and MDA in the POAF group were higher than in the no POAF group; however, there was no difference before the operation. Preoperative ACE and apelin were both significant and independent risk factors for POAF. In conclusion, the high ACE and low apelin preoperatively led to CRP and MDA being increased postoperatively, which was probably associated with POAF after OPCABG. Apelin may be a new predictor for POAF.
authors.affiliation: Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China; Department of Cardiovascular Surgery, General Hospital of Shenyang Military Region, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Cardiovascular Surgery, General Hospital of Shenyang Military Region, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Cardiovascular Surgery, General Hospital of Shenyang Military Region, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
authors.forename: Yin-Li
authors.initials: YL
authors.lastname: Xu
authors.affiliation: Department of Cardiovascular Surgery, General Hospital of Shenyang Military Region, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Wu
authors.affiliation: Department of Cardiovascular Surgery, General Hospital of Shenyang Military Region, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Xue
authors.affiliation: Department of Cardiovascular Surgery, General Hospital of Shenyang Military Region, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
authors.forename: Hui-Shan
authors.identifier: 0000-0001-6523-7488
authors.initials: HS
authors.lastname: Wang
mesh_terms: D000368:Aged; D000804:Angiotensin II / Q000097:blood; D000073861:Apelin; D001281:Atrial Fibrillation / Q000209:etiology* / Q000503:physiopathology; D001920:Bradykinin / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007249:Inflammation; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D015999:Multivariate Analysis; D018384:Oxidative Stress; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D011183:Postoperative Complications; D011184:Postoperative Period; D057234:Preoperative Period; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins; D000804:Angiotensin II; D008315:Malondialdehyde; D002097:C-Reactive Protein; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A; D001920:Bradykinin