title: Identification of a Novel HIV Type 1 CRF01_AE/B'/C Recombinant Isolate in Sichuan, China.
abstract: We report in this study a novel HIV-1 unique recombinant virus (XC2014EU01) isolated from an HIV-positive man who infected through heterosexual sex in Sichuan, China. The near full-length genome analyses showed that XC2014EU01 harbored one subtype B segment in pol region and two subtype C segments in gag-pol region in a CRF01_AE backbone. The unique mosaic structure was distinctly different from the other CRF01_AE/B'/C recombinant forms reported. Phylogenetic tree analyses revealed that the subtype B region originated from a Thailand subtype B' lineage, the subtype C regions were from an India C lineage, and the backbone was from CRF01_AE. XC2014EU01 was still identified as CCR5-tropic, and plasma of XC2014EU01 infected person had the media neutralizing activity. The emergence of XC2014EU01 may increase the complexity of the HIV-1 epidemic among high-risk populations and the difficulty of vaccine research and development.
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .|2 Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University , Beijing, People's Republic of China .|3 Clinical Center for HIV/AIDS, Capital Medical University Beijing, People's Republic of China .
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Desheng
authors.initials: D
authors.lastname: Kong
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Weisi
authors.initials: W
authors.lastname: Xu
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Fan
authors.initials: F
authors.lastname: Li
authors.affiliation: 4 Sichuan Center for Disease Control and Prevention , Chengdu, People's Republic of China .
authors.forename: Shu
authors.initials: S
authors.lastname: Liang
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: 2 Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University , Beijing, People's Republic of China .|3 Clinical Center for HIV/AIDS, Capital Medical University Beijing, People's Republic of China .
authors.forename: Fujie
authors.initials: F
authors.lastname: Zhang
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
authors.affiliation: 1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
authors.forename: Liying
authors.initials: L
authors.lastname: Ma
mesh_terms: D002681:China; D016679:Genome, Viral; D005838:Genotype; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
keywords: HIV-1; coreceptor tropism; neutralizing activity; recombinant