title: Fertility enhancing activity and toxicity profile of aqueous extract of Chasmanthera dependens roots in male rats.
abstract: This study evaluated the fertility-enhancing activity and safety of aqueous extract of Chasmanthera dependens root (AECDR) in male rats. In the fertility study, twenty, sodium arsenite (10 mg/kg) body weight (BW)-treated male rats (171.02 ± 3.36 g), assigned into four groups (I-IV), received 1 ml of distilled water (DW), 25, 50 and 100 mg/kg BW of AECDR for 60 days, whereas the control received DW. After 7 days of pairing with female rats (153.67 ± 2.24 g), spermatogenic, fertility, testicular function indices and enzymatic antioxidant activities were evaluated. The animal groupings in the toxicity study were similar to the fertility study except no administration of sodium arsenite. Sodium arsenite treatment-related decreases (p < .05) in the semen and sperm parameters, testicular function indices, antioxidant activities and female rat fertility indices were reversed/ameliorated by AECDR. AECDR significantly altered the function indices of the liver and kidney and the lipid profile and selectively altered the haematological parameters. There was no treatment-related histoarchitectural changes in the organs. Overall, the aqueous extract of C. dependens roots exhibited pro-spermatogenic, fertility enhancing, antioxidant and androgenic activities in male rats. It also exhibited functional toxicity. Therefore, the chronic use of AECDR may not be completely safe as oral remedy.
authors.affiliation: Phytopharmacology, Toxicology and Reproductive Biochemistry Research Laboratory, Department of Biochemistry, University of Ilorin, Ilorin, Nigeria.
authors.forename: A L
authors.initials: AL
authors.lastname: Quadri
authors.affiliation: Phytopharmacology, Toxicology and Reproductive Biochemistry Research Laboratory, Department of Biochemistry, University of Ilorin, Ilorin, Nigeria.
authors.forename: M T
authors.initials: MT
authors.lastname: Yakubu
mesh_terms: D000818:Animals; D018053:Arsenites / Q000494:pharmacology; D005298:Fertility / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D017670:Sodium Compounds / Q000494:pharmacology; D013081:Sperm Motility / Q000187:drug effects / Q000502:physiology; D013091:Spermatogenesis / Q000187:drug effects / Q000502:physiology; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D064028:Tracheophyta
chemical_list: D018053:Arsenites; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D017670:Sodium Compounds; C017947:sodium arsenite
keywords: 
  Chasmanthera dependens
  ; functional toxicity; male fertility; menispermaceae; sodium arsenite