title: [Psychological Characteristics of Patients With Stress-induced Arterial Hypertension: a Violation of the Regulation of Emotions as a Central Link of Pathogenesis].
abstract: The study of emotional and personality characteristics of patients with hypertension in the workplace (HW) and comparative assessment of the effectiveness of antihypertensive therapy in these patients.
  
  
  
  The study included 170 patients c hypertensive disease stage II, 1-2-th degree, aged 32-52 years, including 85 patients with and 85 patients without WAH, and 82 healthy subjects matched for age and sex. To carry out simulation of the situation of emotional intensity (level of claims assessment process - UE) and a modified version of the test Rosenzweig. Patients with WAH were randomized into 2 groups: patients of group 1 received bisoprolol, 2nd group -eprosartan. If target blood pressure (BP) in 2 weeks, all patients were added indapamide retard. At baseline and after 16 weeks of treatment was carried out daily monitoring of blood pressure and the working day.
  
  
  
  When modeling a situation of emotional intensity in patients with WAP become, compared with patients without a healthy and WAH, revealed (1) marked increase in systolic blood pressure - 16.1, 4.1 and 3.0 mmHg, respectively (p <0,001 ), (2) the dominance of motivation "avoid failure" (UP underestimated in 34.1% of cases, unformed UP - in 21.2% of cases, healthy - 14.6% and 3.7% of cases, cootvetstvenno, p<0,001 in patients without WAH - 20% and 11.8%, respectively, p<0,05). Patients with WAP become different from normal was significantly (p<0.05) the number of the selected blshim emotionally meaningful situations (9.7 and 7.8, respectively) and emotional descriptors (11 and 7, respectively). Patients with WAH differ significantly (p<0,05) more frequent than in healthy, the use of ineffective strategies of emotion regulation in an emotionally meaningful situations: the suppression of the expression of emotions (38.3 and 20.3%, respectively), rumination and disasterization (19 and 11.8%, respectively) and more rare - high performance: sequential actualization of new meanings (25.7 and 31.7%, respectively) and the strategy of interactive subject-subject transformations (12.6 and 25.2%, respectively). After 16 weeks of treatment showed a significant (p<0,001) reduction of blood pressure in the 1st and 2nd groups. The number of patients achieving target blood pressure, at 2, 4 and 6 weeks, respectively, was as follows: 14 in the bisoprolol group and 93 (100%), in the eprosartan group - 0, 52 (100%). Both groups showed significant (p <0,001) reduction in mean daytime and nighttime blood pressure in the weekdays and weekends. In the group of bisoprolol showed a significant (p <0,01) higher average daily decrease in systolic blood pressure in the working day, compared with eprosartan group (26.2 and 19.3 mm Hg, respectively).
  
  
  
  Patients with WAP become emotionally meaningful situations frequently resorted to repression of emotions, choose the inefficient strategies of emotion regulation, they noted the expressed reaction of BP in response to the emotional burden. Antihypertensive therapy based on bisoprolol, is highly effective and has advantages over circuit-based therapy with eprosartan.
authors.affiliation: Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia.|Sechenov First Moscow State Medical University, Moscow, Russia.|M.V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: O D
authors.initials: OD
authors.lastname: Ostroumova
authors.affiliation: Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia.|Sechenov First Moscow State Medical University, Moscow, Russia.|M.V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Pervichko
authors.affiliation: Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia.|Sechenov First Moscow State Medical University, Moscow, Russia.|M.V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Y P
authors.initials: YP
authors.lastname: Zinchenko
mesh_terms: D000179:Acrylates / Q000627:therapeutic use; D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D017298:Bisoprolol / Q000627:therapeutic use; D001794:Blood Pressure; D001795:Blood Pressure Determination; D004644:Emotions; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000523:psychology / Q000628:therapy; D007093:Imidazoles / Q000627:therapeutic use; D007190:Indapamide / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013315:Stress, Psychological / Q000150:complications*; D013876:Thiophenes / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000179:Acrylates; D000959:Antihypertensive Agents; D007093:Imidazoles; D013876:Thiophenes; C068373:eprosartan; D007190:Indapamide; D017298:Bisoprolol
keywords: ambulatory blood pressure monitoring; antihypertensive therapy; arterial hypertension; bisoprolol; emotion regulation strategies; emotional stress