title: Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS).
abstract: International Society for CNS Clinical Trials and Methodology convened an expert working-group that assembled consistency/inconsistency flags for the Positive and Negative Syndrome Scale (PANSS). Twenty-four flags were identified and divided based on extent to which they represent error (Possibly, Probably, Very probably or definitely). The flags were applied to assessments derived from the NEWMEDS data repository and the CATIE clinical trial data. Almost 40% of ratings had at least one inconsistency flag raised and 10% had two. Application of flags to clinical rating can improve reliability and validity of trials.
authors.affiliation: Bar Ilan University, Ramat Gan, Israel. Electronic address: Jonathan.Rabinowitz@biu.ac.il.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rabinowitz
authors.affiliation: SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Nina R
authors.initials: NR
authors.lastname: Schooler
authors.affiliation: UCLA, Department of Psychiatry and Biobehavioral Sciences, 760 Westwood Plaza, Ste. 28-224, Los Angeles, CA 90095, USA.
authors.forename: Ariana
authors.initials: A
authors.lastname: Anderson
authors.affiliation: Multi-Health Systems, Inc., Research & Development, Clinical/Education/Public Safety Division, 3770 Victoria Park Avenue, Toronto, ON M2H 3M6, Canada.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Ayearst
authors.affiliation: Bracket Global, LLC, PO Box 7137, McLean, VA 22106, USA.
authors.forename: David
authors.initials: D
authors.lastname: Daniel
authors.affiliation: Tel Aviv University, Tel Aviv, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Davidson
authors.affiliation: Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
authors.forename: Anzalee
authors.initials: A
authors.lastname: Khan
authors.affiliation: Lundbeck LLC, 6 Parkway North, Suite 400, Deerfield, IL 60015, USA.
authors.forename: Bruce
authors.initials: B
authors.lastname: Kinon
authors.affiliation: Groupe Hospitalier COCHIN, Pavillon TARNIER, 27 rue du Faubourg Saint-Jacques, France.
authors.forename: Francois
authors.initials: F
authors.lastname: Menard
authors.affiliation: Long Island University, 1 University Plaza, Brooklyn, NY 11201, USA.
authors.forename: Lewis
authors.initials: L
authors.lastname: Opler
authors.affiliation: ProPhase LLC, 3 Park Avenue, New York, NY 10016 & NYU School of Medicine, Dept. of Psychiatry, 1 Park Avenue, New York, NY 10016, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Opler
authors.affiliation: 11629 Danville Drive, Rockville, MD 20852, USA.
authors.forename: Joanne B
authors.initials: JB
authors.lastname: Severe
authors.affiliation: Janssen Scientific Affairs, LLC, 1125 Trenton-Harbourton Rd, Titusville, NJ 08560, USA.
authors.forename: David
authors.initials: D
authors.lastname: Williamson
authors.affiliation: Cronos CCS, 201 South Main Street, Lambertville, NJ 08530, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Yavorsky
authors.affiliation: Abbvie Pharma, R436, Bldg AP9A-2, 1 North Waukegan Road, North Chicago, IL 60064, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
mesh_terms: D002986:Clinical Trials as Topic; D019992:Databases as Topic; D006801:Humans; D011569:Psychiatric Status Rating Scales; D058996:Quality Improvement; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000175:diagnosis*