title: Hereditary Persistence of Alpha-Fetoprotein Is Associated with the -119G>A Polymorphism inAFPGene.
abstract: Alpha-fetoprotein (AFP) is a glycoprotein that is produced by the liver and yolk sac during fetal development. Its levels are usually raised in malignant conditions. Hereditary persistence of AFP (HPAFP) is a rare benign condition with elevated levels of AFP. It is inherited in a dominant mode with complete penetrance and is usually not associated with any clinical disability. We report two individuals with elevated levels of AFP harboring the -119G>A polymorphism in theAFPgene. A genetic screening to rule out variants in theAFPgene is advised in cases with unexplained persistent AFP levels to avoid inappropriate treatment and surgical options.
authors.affiliation: Asian Healthcare Foundation, Hyderabad, Telangana, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Deshpande
authors.affiliation: Asian Institute of Gastroenterology, Hyderabad, Telangana, India.
authors.forename: Radhika
authors.initials: R
authors.lastname: Chavan
authors.affiliation: Asian Healthcare Foundation, Hyderabad, Telangana, India.
authors.forename: Govardhan
authors.initials: G
authors.lastname: Bale
authors.affiliation: Asian Healthcare Foundation, Hyderabad, Telangana, India.
authors.forename: Urmila Steffie
authors.initials: US
authors.lastname: Avanthi
authors.affiliation: Asian Institute of Gastroenterology, Hyderabad, Telangana, India.
authors.forename: Mohsin
authors.initials: M
authors.lastname: Aslam
authors.affiliation: Asian Institute of Gastroenterology, Hyderabad, Telangana, India.
authors.forename: Mohan
authors.initials: M
authors.lastname: Ramchandani
authors.affiliation: Asian Healthcare Foundation, Hyderabad, Telangana, India; Asian Institute of Gastroenterology, Hyderabad, Telangana, India.
authors.forename: D Nageshwar
authors.initials: DN
authors.lastname: Reddy
authors.affiliation: Asian Healthcare Foundation, Hyderabad, Telangana, India.
authors.forename: V V
authors.initials: VV
authors.lastname: Ravikanth