title: Can osteoporosis increase the incidence of heart failure in adults?
abstract: Recent studies have suggested shared comorbidities between heart failure and osteoporosis. In addition, patients with osteoporosis are associated with increased risks of developing cardiovascular disease.
  
  
  
  A retrospective cohort analysis was conducted to determine the association between osteoporosis and heart failure. Data was from the Longitudinal Health Insurance Database 2000 (LHID 2000), Taiwan. Patients with newly diagnosed osteoporosis were identified, and osteoporosis-free controls were randomly selected from the general population and frequency matched according to age, sex, and index year using the LHID 2000. We analyzed the risks of heart failure using Cox proportional-hazards regression models.
  
  
  
  During the mean follow-up of 7.1 ± 3.5 years, the cumulative incidence of heart failure was 2.24% higher in the osteoporosis cohort than in the comparison cohort (p < .001). The overall incidence of heart failure was 10.3 versus 7.62 per 1000 person-years in osteoporosis patients and controls, respectively, with an adjusted HR of 1.13 (95% CI = 1.06-1.21).
  
  
  
  We observed a higher incidence of developing heart failure in Taiwanese adults with osteoporosis, especially in those with chronic comorbidities. There might be linking pathophysiology and mechanisms from osteoporosis to heart failure.
authors.affiliation: a School of Medicine , Fu-Jen Catholic University , New Taipei , Taiwan.|b Division of Cardiology , Shin-Kong Wu Ho-Su Memorial Hospital , Taipei , Taiwan.
authors.forename: Chiung-Zuan
authors.initials: CZ
authors.lastname: Chiu
authors.affiliation: a School of Medicine , Fu-Jen Catholic University , New Taipei , Taiwan.|c Division of Neurology , Shin-Kong Wu Ho-Su Memorial Hospital , Taipei , Taiwan.
authors.forename: Jiann-Horng
authors.initials: JH
authors.lastname: Yeh
authors.affiliation: b Division of Cardiology , Shin-Kong Wu Ho-Su Memorial Hospital , Taipei , Taiwan.
authors.forename: Kou-Gi
authors.initials: KG
authors.lastname: Shyu
authors.affiliation: d Division of Orthopedics , Shin-Kong Wu Ho-Su Memorial Hospital , Taipei , Taiwan.
authors.forename: Sheng-Mou
authors.initials: SM
authors.lastname: Hou
authors.affiliation: e Management Office for Health Data, China Medical University Hospital , Taichung , Taiwan.|f College of Medicine , China Medical University , Taichung , Taiwan.
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Lin
authors.affiliation: g Department of Radiation Oncology , China Medical University Hospital , Taichung , Taiwan.|h Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine , China Medical University , Taichung , Taiwan.
authors.forename: Ji-An
authors.initials: JA
authors.lastname: Liang
mesh_terms: D000368:Aged; D015331:Cohort Studies; D015897:Comorbidity; D016208:Databases, Factual; D005260:Female; D006333:Heart Failure / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications* / Q000453:epidemiology; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan
keywords: Comorbidity; heart failure; osteoporosis; retrospective cohort analysis