title: Single Nucleotide Polymorphisms in the PTPN1 Gene Are Associated with Susceptibility to Esophageal Squamous Cell Carcinoma: A Case-Control Study in Inner Mongolia, China.
abstract: OBJECTIVE
  This case-control study investigated the association of single nucleotide polymorphisms in the PTPN1 gene with susceptibility to esophageal squamous cell carcinoma (ESCC) in Inner Mongolia, China.
  
  
  METHODS
  A total of 302 patients living in Inner Mongolia China who were pathologically diagnosed with ESCC between April 2012 and 2016 were selected for the ESCC group; 373 healthy individuals were selected for the control group. The rs2904268 C>G, rs2230605 A>G, and rs16995309 C>T polymorphisms in the PTPN1 gene were detected by bidirectional polymerase chain reaction amplification of specific alleles. The haplotype frequencies were analyzed by SHEsis software. Binary logistic regression analysis was conducted to analyze risk factors associated with ESCC.
  
  
  RESULTS
  Statistical differences between the ESCC and control groups were observed for history of smoking, drinking, and poor eating habits (all p < 0.05). Both the rs2904268 C>G CG and GG genotype frequencies were markedly higher in the ESCC group relative to the control group (both p < 0.05). However, the genotype frequencies of rs2230605 A>G and rs16995309 C>T were similar between the ESCC and control groups (all p > 0.05). Compared with the control group, the ESCC group had notably elevated frequencies of the GGC and GAT haplotypes and significantly reduced frequencies of CGC and GGT haplotypes (all p < 0.05). A history of smoking, drinking, poor eating habits, the rs2904268 C>G CG+GG genotypes, and the GAT haplotype were all identified as risk factors for ESCC (all p < 0.05).
  
  
  CONCLUSIONS
  These results indicated that the PTPN1 gene polymorphism rs2904268 is associated with susceptibility to ESCC in Inner Mongolia.
authors.affiliation: Department of Medical Oncology in Section One, Chifeng Municipal Hospital , Chifeng, China .
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Ji
authors.affiliation: Department of Medical Oncology in Section One, Chifeng Municipal Hospital , Chifeng, China .
authors.forename: Le-Le
authors.initials: LL
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology in Section One, Chifeng Municipal Hospital , Chifeng, China .
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology in Section One, Chifeng Municipal Hospital , Chifeng, China .
authors.forename: Sheng-Jie
authors.initials: SJ
authors.lastname: Yin
authors.affiliation: Department of Medical Oncology in Section One, Chifeng Municipal Hospital , Chifeng, China .
authors.forename: Di
authors.initials: D
authors.lastname: Shang
authors.affiliation: Department of Medical Oncology in Section One, Chifeng Municipal Hospital , Chifeng, China .
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Sun
authors.affiliation: Department of Medical Oncology in Section One, Chifeng Municipal Hospital , Chifeng, China .
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D000328:Adult; D000483:Alleles; D001483:Base Sequence / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004938:Esophageal Neoplasms / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics
chemical_list: C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
keywords: Inner Mongolia; PTPN1; case–control study; esophageal squamous cell carcinoma; single nucleotide polymorphism; susceptibility