title: [The expression of claudins in colonic neoplasms].
abstract: OBJECTIVE
  the evaluation of localization claudin-1, -3 and -4 types of cancer and colon polyps.
  
  
  METHODS
  The study included 32 colon adenocarcinoma and 86 polyps. Antibody claudin-1; -3 and -4 were used as immunohistochemical markers in this study.
  
  
  RESULTS
  84/118, 64/118, 52/118 reaction with claudin-1, claudin-3 and claudin-4 in cancer and colon polyps had a membrane localization, respectively. In 33 (27.9%) cases was found paradoxical reaction claudin-1; in 50 (42.4%) - a paradoxical reaction claudin-3 in 66 (55.9%) - a paradoxical reaction claudin-4. Among the paradoxical claudin reaction nuclear localization of marker was observed relatively rarely: claudin-3 in 2.5% cases of colon cancer; claudin-4 in 8.5% of colon polyps.
  
  
  CONCLUSIONS
  Mislocalization claudin-3 to nucleus in colon cancer and mislocalization claudin-4 to nucleus in adenomas of the colon were detected for the first time. The potential reasons for the paradoxical expression are discussed and a review of the literature, related all the alleged mechanisms of this mislocalization is provided.
authors.affiliation: Lomonosov Moscow State University, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Oleinikova
authors.affiliation: Lomonosov Moscow State University, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Kharlova
authors.affiliation: Lomonosov Moscow State University, Moscow, Russia; Russian Medical Academy of Postgraduate Education Ministry of Health of Russia, Moscow, Russia.
authors.forename: P G
authors.initials: PG
authors.lastname: Mal'kov
authors.affiliation: Lomonosov Moscow State University, Moscow, Russia; Russian Medical Academy of Postgraduate Education Ministry of Health of Russia, Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Danilova
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000236:Adenoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002467:Cell Nucleus / Q000235:genetics; D062445:Claudin-1 / Q000096:biosynthesis* / Q000235:genetics; D062465:Claudin-3 / Q000096:biosynthesis* / Q000235:genetics; D062506:Claudin-4 / Q000096:biosynthesis* / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000378:metabolism / Q000473:pathology
chemical_list: D062445:Claudin-1; D062465:Claudin-3; D062506:Claudin-4