title: Intra-patient comparison of reduced-dose model-based iterative reconstruction with standard-dose adaptive statistical iterative reconstruction in the CT diagnosis and follow-up of urolithiasis.
abstract: OBJECTIVE
  To evaluate the accuracy of reduced-dose CT scans reconstructed using a new generation of model-based iterative reconstruction (MBIR) in the imaging of urinary tract stone disease, compared with a standard-dose CT using 30% adaptive statistical iterative reconstruction.
  
  
  METHODS
  This single-institution prospective study recruited 125 patients presenting either with acute renal colic or for follow-up of known urinary tract stones. They underwent two immediately consecutive scans, one at standard dose settings and one at the lowest dose (highest noise index) the scanner would allow. The reduced-dose scans were reconstructed using both ASIR 30% and MBIR algorithms and reviewed independently by two radiologists. Objective and subjective image quality measures as well as diagnostic data were obtained.
  
  
  RESULTS
  The reduced-dose MBIR scan was 100% concordant with the reference standard for the assessment of ureteric stones. It was extremely accurate at identifying calculi of 3 mm and above. The algorithm allowed a dose reduction of 58% without any loss of scan quality.
  
  
  CONCLUSIONS
  A reduced-dose CT scan using MBIR is accurate in acute imaging for renal colic symptoms and for urolithiasis follow-up and allows a significant reduction in dose.
  
  
  CONCLUSIONS
  • MBIR allows reduced CT dose with similar diagnostic accuracy • MBIR outperforms ASIR when used for the reconstruction of reduced-dose scans • MBIR can be used to accurately assess stones 3 mm and above.
authors.affiliation: Peninsula Radiology Academy, William Prance Rd, Plymouth, PL6 5WR, UK. sean.tenant@nhs.net.
authors.forename: Sean
authors.identifier: http://orcid.org/0000-0003-4005-4663
authors.initials: S
authors.lastname: Tenant
authors.affiliation: Peninsula Radiology Academy, William Prance Rd, Plymouth, PL6 5WR, UK.
authors.forename: Chun Lap
authors.initials: CL
authors.lastname: Pang
authors.affiliation: Peninsula Radiology Academy, William Prance Rd, Plymouth, PL6 5WR, UK.
authors.forename: Prageeth
authors.initials: P
authors.lastname: Dissanayake
authors.affiliation: Plymouth University Peninsula Schools of Medicine and Dentistry, John Bull Building, Plymouth, PL6 8BU, UK.|Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Varut
authors.initials: V
authors.lastname: Vardhanabhuti
authors.affiliation: Plymouth Hospitals NHS Trust, Derriford Rd, Plymouth, PL6 8DH, UK.
authors.forename: Colin
authors.initials: C
authors.lastname: Stuckey
authors.affiliation: Plymouth Hospitals NHS Trust, Derriford Rd, Plymouth, PL6 8DH, UK.
authors.forename: Catherine
authors.initials: C
authors.lastname: Gutteridge
authors.affiliation: University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: Hyde
authors.affiliation: Plymouth University Peninsula Schools of Medicine and Dentistry, John Bull Building, Plymouth, PL6 8BU, UK.|Plymouth Hospitals NHS Trust, Derriford Rd, Plymouth, PL6 8DH, UK.
authors.forename: Carl
authors.initials: C
authors.lastname: Roobottom
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011829:Radiation Dosage; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D056844:Renal Colic / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*; D052878:Urolithiasis / Q000000981:diagnostic imaging*; D055815:Young Adult
keywords: Computed tomography; Kidney; Radiation dosage; Renal colic; Urolithiasis