title: Transcription elongation.
abstract: This review is focused on recent progress in understanding how Escherichia coli RNAP polymerase translocates along the DNA template and the factors that affect this movement. We discuss the fundamental aspects of RNAP translocation, template signals that influence forward or backward movement, and host or phage factors that modulate translocation.
authors.affiliation: a PHRI Center, NJMS, Rutgers, The State University of New Jersey , Newark , NJ , USA.
authors.forename: Arkady
authors.initials: A
authors.lastname: Mustaev
authors.affiliation: b Department of Molecular Biology and Genetics , Cornell University , Ithaca , NY , USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Roberts
authors.affiliation: c Department of Microbiology & Immunology , Columbia University Medical Center , New York , NY , USA.
authors.forename: Max
authors.initials: M
authors.lastname: Gottesman
mesh_terms: D004269:DNA, Bacterial / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D061805:Transcription Elongation, Genetic / Q000502:physiology*
chemical_list: D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D012321:DNA-Directed RNA Polymerases
keywords: Gre A/B; RNAP backtracking; bacteriophage transcription factors; transcription elongation; transcription-coupled repair