title: Transformation of marginal zone lymphoma (and association with other lymphomas).
abstract: Marginal zone lymphomas (MZL) are a diverse group of indolent lymphoproliferative disorders that comprise three subtypes: nodal, splenic and mucosal associated marginal zone lymphomas (MALT). Histologic transformation (HT) to an aggressive lymphoma is a rare event that can occur in any subtype, and at lower frequency compared to other indolent non Hodgkin lymphomas (NHL) like follicular lymphoma. There are few data directly associated with risk and prognosis of transformation in MZL. However, recent advances in the understanding of molecular and genetic features of MALT have contributed to an evolving appreciation of HT in this disease. Optimal treatment of HT of MZL remains unknown. Much of the approach to managing transformed MZL is extrapolated from other indolent NHLs.
authors.affiliation: Wilmot Cancer Institute, University of Rochester, 601 Elmwood Avenue, Box 704, Rochester, NY 14642, USA. Electronic address: carla_casulo@urmc.rochester.edu.
authors.forename: Carla
authors.initials: C
authors.lastname: Casulo
authors.affiliation: Wilmot Cancer Institute, University of Rochester, 601 Elmwood Avenue, Box 704, Rochester, NY 14642, USA. Electronic address: jonathan_friedberg@urmc.rochester.edu.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Friedberg
mesh_terms: D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D012307:Risk Factors
keywords: Aggressive lymphoma; Marginal zone lymphoma; Non-Hodgkin lymphoma; Transformation