title: Extracorporeal photopheresis in pediatric patients: Practical and technical considerations.
abstract: In adults, extracorporeal photopheresis (ECP) is widely utilized for a variety of indications, most commonly cutaneous T-cell lymphoma, acute or chronic graft-versus-host disease (GVHD), solid organ transplant rejection, and other autoimmune and T-cell-mediated disorders. In pediatric patients, the majority of case series and reports have focused on its use in the management of acute and chronic GVHD. Currently utilized ECP technologies were designed for adult patients and there are several challenges in adapting these technologies for use in children. In our review, we focus on practical considerations and procedural modifications for ECP use in pediatric patients, with special attention to patient safety.
authors.affiliation: Department of Pathology and Laboratory Medicine, New York-Presbyterian Hospital-Weill Cornell Medicine, New York, New York.
authors.forename: Robert A
authors.identifier: http://orcid.org/0000-0002-3484-790X
authors.initials: RA
authors.lastname: DeSimone
authors.affiliation: Department of Pathology and Cell Biology, New York-Presbyterian Hospital-Columbia University Medical Center, New York, New York.
authors.forename: Joseph
authors.initials: J
authors.lastname: Schwartz
authors.affiliation: Department of Pediatrics, Division of Hematology/Oncology/Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Schneiderman
mesh_terms: D002648:Child; D006086:Graft vs Host Disease / Q000628:therapy; D006801:Humans; D010372:Pediatrics / Q000379:methods; D017893:Photopheresis / Q000379:methods* / Q000592:standards; D013673:Technology Assessment, Biomedical
keywords: extracorporeal photopheresis (ECP); graft-versus-host disease (GVHD); pediatrics; therapeutic apheresis