title: Visual Field Progression is Associated with Systemic Concentration of Macrophage Chemoattractant Protein-1 in Normal-Tension Glaucoma.
abstract: To investigate the associations between endothelin-1 (ET-1) and macrophage chemoattractant protein-1 (MCP-1) levels and visual field (VF) progression in normal-tension glaucoma (NTG).
  
  
  
  We conducted a prospective, longitudinal study in 71 patients with NTG. Blood samples from all subjects were assayed for ET-1 and MCP-1 concentrations, and baseline ophthalmic examinations, including the VF, were performed. Baseline data were compared with follow-up data over 3 years.
  
  
  
  After 3 years of follow-up, 14 of the 71 patients showed VF progression, and the systemic MCP-1 level was significantly associated with VF progression (r = 0.318, p = 0.007). Multiple regression analysis showed that VF progression was significantly associated with MCP-1 (odds ratio, OR = 1.021, 95% CI = 1.003-1.040; p = 0.020) and optic disc hemorrhage (ODH; OR = 1.573; 95% CI = 1.140-2.170; p = 0.023).
  
  
  
  Systemic MCP-1 levels were associated with VF progression in patients with NTG.
authors.affiliation: a College of Medicine , The Catholic University of Korea , Seoul , Korea.|b Department of Ophthalmology , Incheon St. Mary's Hospital , Incheon , Korea.
authors.forename: Na Young
authors.initials: NY
authors.lastname: Lee
authors.affiliation: a College of Medicine , The Catholic University of Korea , Seoul , Korea.|c Department of Ophthalmology , Yeouido St. Mary's Hospital , Seoul , Korea.
authors.forename: Min Hee
authors.initials: MH
authors.lastname: Kim
authors.affiliation: a College of Medicine , The Catholic University of Korea , Seoul , Korea.|d Department of Ophthalmology , Seoul St. Mary's Hospital , Seoul , Korea.
authors.forename: Chan Kee
authors.initials: CK
authors.lastname: Park
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D018932:Chemokine CCL2 / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D057066:Low Tension Glaucoma / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012607:Scotoma / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D013997:Time Factors; D014794:Visual Fields / Q000502:physiology*
chemical_list: D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2
keywords: Endothelin-1; macrophage chemoattractant protein-1; normal-tension glaucoma; progression; visual field