title: Toll-like receptors as a key regulator of mesenchymal stem cell function: An up-to-date review.
abstract: Understanding the role of toll-like receptors (TLRs) in the immunomodulation potential, differentiation, migration, and survival of mesenchymal stem cells (MSCs) is absolutely vital to fully exploiting their MSC-based therapeutic potential. Furthermore, through recognition of exogenous or endogenous ligands produced upon injury, TLRs have been linked to allograft rejection and maintenance of chronic inflammatory diseases, including Crohn's disease, rheumatoid arthritis. Characterizing the effect of TLRs in biological control of MSCs fate and function could improve our knowledge about the MSC-based cell therapy and immunotherapy. In this paper, we outline the impacts of TLR activation and mechanisms on MSCs immunomodulatory functions, differentiation, migration, and survivability. Moreover, we indicate that the expression patterns of TLRs in MSCs from different sources.
authors.affiliation: Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Solmaz
authors.initials: S
authors.lastname: Shirjang
authors.affiliation: Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Mansoori
authors.affiliation: Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Solali
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Majid Farshdousti
authors.initials: MF
authors.lastname: Hagh
authors.affiliation: Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Shamsk@tbzmed.ac.ir.
authors.forename: Karim
authors.initials: K
authors.lastname: Shamsasenjan
mesh_terms: D050156:Adipogenesis / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage; D002465:Cell Movement / Q000502:physiology; D020219:Chondrogenesis / Q000502:physiology; D011992:Endosomes / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000502:physiology; D007249:Inflammation / Q000503:physiopathology; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D051379:Mice; D009928:Organ Specificity; D010012:Osteogenesis / Q000502:physiology; D000069452:Pathogen-Associated Molecular Pattern Molecules; D051193:Toll-Like Receptors / Q000502:physiology*
chemical_list: D000069452:Pathogen-Associated Molecular Pattern Molecules; D051193:Toll-Like Receptors
keywords: Immunology; Mechanism; Mesenchymal stem cell; Therapeutic use; Toll-like receptor