title: In vivo characterization of monolithic matrix type transdermal drug delivery systems of pinacidil monohydrate: A technical note.
abstract: The present work aimed to characterize transdermal drug delivery systems of pinacidil monohydrate in vivo by monitoring the effect of the TDDS on blood pressure of methyl prednisolone acetate induced hypertensive rats. The blood pressure of rats was measured using a noninvasive rat BP instrument based on cuff tail technique. A significant fall in rat BP (P<.01) was observed in treatment of hypertensive rats with all the formulations, which was maintained for 48 hours. Interformulation comparison revealed that formulation B-4 was the most effective with 37.96% reduction in BP (160.33±4.96 vs 99.44±4.46 mmHg). It was concluded that a single patch application of pinacidil TDDS (B-4) can effectively control hypertension in rats for 2 days. The system holds promise for clinical studies.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, 110 062, New Delhi, India. aqilmalik@yahoo.com.
authors.forename: Mohd
authors.initials: M
authors.lastname: Aqil
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, 110 062, New Delhi, India.
authors.forename: Asgar
authors.initials: A
authors.lastname: Ali
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Hamdard University, 110 062, New Delhi, India.
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Sultana
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Hamdard University, 110 062, New Delhi, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Dubey
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Hamdard University, 110 062, New Delhi, India.
authors.forename: Abul K
authors.initials: AK
authors.lastname: Najmi
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Hamdard University, 110 062, New Delhi, India.
authors.forename: Kollapa K
authors.initials: KK
authors.lastname: Pillai
keywords: hypertension; methylprednisolone acetate; pinacidil; rat; transdermal drug delivery system