title: Exogeneous cyclic AMP blocks the muscarinic receptor-mediated intracellular Ca2+-release in the gastrulating chick embryo cells.
abstract: Exogeneous cyclic AMP (cAMP, 10-8M), when added together with acetylcholine (ACh, 500 μM) to dissociated chick embryo cells, blocked the ACh-stimulated increase in the level of cytosolic free Ca2+([Ca2+]i). This inhibiting action of exogeneous cAMP is probably mediated by intracellular cyclic GMP (cGMP) and cAMP.
authors.affiliation: Institute of Chemical Physics and Biophysics, Estonian Academy of Sciences, USSR.
authors.forename: Tiit
authors.initials: T
authors.lastname: Laasberg
keywords: Chick embryo; Cytosolic free Ca2+; Exogeneous cAMP; Gastrulation; Intra-cellular cGMP; Muscarinic receptor