title: Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction.
abstract: Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whether vitamin D-binding protein expression is altered in fetal growth restriction-associated placental dysfunction. Protein was extracted from 35 placentae derived from 17 healthy control subjects and 18 gestation-matched subjects with fetal growth restriction (FGR). FGR subjects were further subdivided as idiopathic (n= 9) and nonidiopathic (n= 9). Vitamin D-binding protein and 25(OH) vitamin D were measured by ELISA and normalized to protein concentration. The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR,p< 0.05, Student'st-test) that were strongly associated with idiopathic fetal growth restriction (p< 0.01, Kruskal-Wallis), whereas levels of vitamin D-binding protein were not associated with placental 25(OH) vitamin D stores (p= 0.295, Pearson's correlation). As such, vitamin D-binding protein may be a factor in unexplained placental dysfunction associated with idiopathic fetal growth restriction and may potentially serve as a biomarker of this disease.
authors.affiliation: Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women's Hospital, Parkville, VIC 3052, Australia.
authors.forename: Alice F
authors.initials: AF
authors.lastname: Wookey
authors.affiliation: Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women's Hospital, Parkville, VIC 3052, Australia.
authors.forename: Tejasvy
authors.initials: T
authors.lastname: Chollangi
authors.affiliation: Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women's Hospital, Parkville, VIC 3052, Australia.
authors.forename: Hannah E J
authors.initials: HE
authors.lastname: Yong
authors.affiliation: Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women's Hospital, Parkville, VIC 3052, Australia.
authors.forename: Bill
authors.identifier: 0000-0002-0132-9858
authors.initials: B
authors.lastname: Kalionis
authors.affiliation: Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women's Hospital, Parkville, VIC 3052, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women's Hospital, Parkville, VIC 3052, Australia.
authors.forename: Shaun P
authors.identifier: 0000-0003-3070-6971
authors.initials: SP
authors.lastname: Brennecke
authors.affiliation: Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women's Hospital, Parkville, VIC 3052, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women's Hospital, Parkville, VIC 3052, Australia; Department of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3168, Australia.
authors.forename: Padma
authors.identifier: 0000-0003-2535-5134
authors.initials: P
authors.lastname: Murthi
authors.affiliation: Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women's Hospital, Parkville, VIC 3052, Australia.
authors.forename: Harry M
authors.identifier: 0000-0003-0553-9489
authors.initials: HM
authors.lastname: Georgiou
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D047109:Fetal Development; D005317:Fetal Growth Retardation / Q000378:metabolism*; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D014809:Vitamin D-Binding Protein / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D014809:Vitamin D-Binding Protein