title: [Structural and Functional Remodeling of Vascular Wall in Persons With Family History of Hypertension].
abstract: Aim of investigation - to study parameters of structural and functional remodeling of vascular wall in persons with family history of hypertension (with burdened or positive hypertensive heredity). We examined 95 persons (aged 17 - 28 years) with family history of hypertension (positive hypertensive heredity) and divided them into 3 groups: group 1 - patients with arterial hypertension (AH), group 2 - patients with high normal blood pressure (BP), group 3 - persons with normal BP). Control (C) group comprised 24 subjects with normal BP without family history of AH. Examination included ultrasound investigation of brachial artery (BA) and common carotid artery, assessment of endothelial-dependent flow-mediated dilatation (EDFMD) of BA, calculation of parameters of distensibility coefficient of vascular wall. EDFMD in groups 1 and 2 was lower than in controls, and corresponded to values of carotid intima-media thickness (CIMT) (<0.001). Mean values of arterial wall distensibility coefficient in persons with family history of AH were smaller than in control group (=0.0001 - <0.005). Lowest mean values of common carotid artery elasticity coefficient as well as highest pulse wave propagation velocity along elastic type vessels was observed in group 1. Thus patients with family history of AH even at early stages had signs of endothelial dysfunction: lowered EDFMD of BA, increased CIMT, lowered elastic properties and increased stiffness of carotid artery wall.
authors.affiliation: Kazan State Medical University, ul. Butlerova, 49, 420012 Kazan, Russia.
authors.forename: S D
authors.initials: SD
authors.lastname: Mayanskaya
authors.affiliation: Kazan State Medical University, ul. Butlerova, 49, 420012 Kazan, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Grebenkina