title: [Renoprotecion With Metabolic Syndrome: the Possibility of Receptor Agonist Imidazoline Moxonidine].
abstract: The article is devoted to the of prevalence, diagnosis, and prognostic significance of renal damage in metabolic syndrome. The pathogenetic mechanisms of development and progression of chronic kidney disease in individuals with obesity, including the role of increased activity of the sympathetic nervous system is discussed. Approaches to the choice of antihypertensive drugs with an emphasis on metabolic and renal protection properties are given. The advantages of imidazoline receptors in neuroprotective of moxonidine in patients with arterial hypertension, metabolic syndrome, and diabetes mellitus is discussed in detail. number of mechanisms of renal protection actions of the agonists of imidazoline receptors is described.
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.|A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
authors.forename: O D
authors.initials: OD
authors.lastname: Ostroumova
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.|A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Zykova
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension; D007093:Imidazoles / Q000627:therapeutic use*; D054755:Imidazoline Receptors / Q000819:agonists*; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D007674:Kidney Diseases / Q000517:prevention & control; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000503:physiopathology
chemical_list: D000959:Antihypertensive Agents; D007093:Imidazoles; D054755:Imidazoline Receptors; C043482:moxonidine
keywords: Metabolic syndrome; antihypertensive treatment; arterial hypertension; microalbuminuria; moxonidine; obesity