title: Influence of measurement uncertainty on the world health organization recommended regulation for mainstream cigarette smoke constituents.
abstract: The World Health Organization Study Group on Tobacco Product Regulation (WHO TobReg) proposed mandated ceilings on 9 prioritized mainstream cigarette smoke constituents determined from the market-specific median of nicotine-normalized yield distributions. Considering the requirements for assessing and reporting of compliance with ceilings, it is of great importance to estimate the measurement uncertainty. To have a better understanding of influence of measurement uncertainty on the WHO recommended regulation for cigarette smoke constituents, in the present study, the measurement uncertainties were evaluated systematically based on series of collaborative studies reported by three different authorities over the years from 2012 to 2016, according to the approaches guided in ISO/TS 21748. Furthermore, the compliance assessment of 20 representative cigarette samples with proposed ceilings was conducted by taking measurement uncertainty into account. This work demonstrated that measurement uncertainty had great influence on the implementation of the regulated mandated lowering of toxic smoke constituents, both on the setting of ceilings and the compliance assessment as well.
authors.affiliation: China National Tobacco Quality Supervision and Test Center, No.2 Fengyang Street, Zhengzhou High and New Technology Industries Development Zone, Zhengzhou 450001, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Deng
authors.affiliation: China National Tobacco Quality Supervision and Test Center, No.2 Fengyang Street, Zhengzhou High and New Technology Industries Development Zone, Zhengzhou 450001, China. Electronic address: lee_zhonghao@sina.com.
authors.forename: Zhonghao
authors.initials: Z
authors.lastname: Li
authors.affiliation: China National Tobacco Quality Supervision and Test Center, No.2 Fengyang Street, Zhengzhou High and New Technology Industries Development Zone, Zhengzhou 450001, China.
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Bian
authors.affiliation: China National Tobacco Quality Supervision and Test Center, No.2 Fengyang Street, Zhengzhou High and New Technology Industries Development Zone, Zhengzhou 450001, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.affiliation: China National Tobacco Quality Supervision and Test Center, No.2 Fengyang Street, Zhengzhou High and New Technology Industries Development Zone, Zhengzhou 450001, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Liu
authors.affiliation: China National Tobacco Quality Supervision and Test Center, No.2 Fengyang Street, Zhengzhou High and New Technology Industries Development Zone, Zhengzhou 450001, China.
authors.forename: Ziyan
authors.initials: Z
authors.lastname: Fan
authors.affiliation: China National Tobacco Quality Supervision and Test Center, No.2 Fengyang Street, Zhengzhou High and New Technology Industries Development Zone, Zhengzhou 450001, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: China National Tobacco Quality Supervision and Test Center, No.2 Fengyang Street, Zhengzhou High and New Technology Industries Development Zone, Zhengzhou 450001, China.
authors.forename: Gangling
authors.initials: G
authors.lastname: Tang
mesh_terms: D006801:Humans; D012016:Reference Values; D012906:Smoke; D062789:Tobacco Products / Q000331:legislation & jurisprudence / Q000592:standards; D035501:Uncertainty; D014944:World Health Organization
chemical_list: D012906:Smoke
keywords: Cigarette smoke constituents; Compliance assessment; Measurement uncertainty; Tobacco regulation