title: Nanoskin® Subcutaneous Implant in Guinea Pigs.
abstract: To evaluate the suitability of Nanoskin, a biomaterial derived from bacterial cellulose, as an alternate material for repairing the posterior lamellae of the eyelids.
  
  
  
  Forty guinea pigs received a fragment of Nanoskin subcutaneously in the dorsal region. The animals received Nanoskin (group 1) or Nanoskin coated with a gelatin layer (group 2). The animals were observed daily for over 7, 30, 90, or 180 days with the subcutaneous implants in place. The animals were euthanized at a designated time and the Nanoskin was removed for histologic, morphometric, and transmission electron microscopy evaluation.
  
  
  
  The results were similar for both groups. The subcutaneously implanted Nanoskin resulted in good tissue integration, induced mild inflammation, and was surrounded by a delicate pseudocapsule.
  
  
  
  The good tissue integration of Nanoskin in study indicates that it may be a potential material for application as a substitute of posterior eyelid lamellar tissue. Further clinical studies are required to confirm the preliminary outcomes of this experimental study.
authors.affiliation: Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil.
authors.forename: Kryscia Natsuaki
authors.initials: KN
authors.lastname: Kaminagakura
authors.affiliation: Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil.
authors.forename: Silvana Sue
authors.initials: SS
authors.lastname: Sato
authors.affiliation: Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil.
authors.forename: Patricia
authors.initials: P
authors.lastname: Sugino
authors.affiliation: Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil.
authors.forename: Daniela Carvalho
authors.initials: DC
authors.lastname: Santos
authors.affiliation: Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil.
authors.forename: Laryssa
authors.initials: L
authors.lastname: Kataki
authors.affiliation: Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil.
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Padovani
authors.affiliation: Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil.
authors.forename: Pierre
authors.initials: P
authors.lastname: Basmaji
authors.affiliation: Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil.
authors.forename: Silvana A
authors.initials: SA
authors.lastname: Schellini
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002482:Cellulose / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005143:Eyelids / Q000601:surgery*; D006168:Guinea Pigs; D049329:Nanostructures; D019736:Prostheses and Implants / Q000648:ultrastructure
chemical_list: D001672:Biocompatible Materials; D002482:Cellulose