title: Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation.
abstract: Purpose The major causes of mortality after allogeneic hematopoietic-cell transplantation (allo-HCT) are relapse, graft-versus-host disease (GVHD), and infection. We have reported previously that alterations in the intestinal flora are associated with GVHD, bacteremia, and reduced overall survival after allo-HCT. Because intestinal bacteria are potent modulators of systemic immune responses, including antitumor effects, we hypothesized that components of the intestinal flora could be associated with relapse after allo-HCT. Methods The intestinal microbiota of 541 patients admitted for allo-HCT was profiled by means of 16S ribosomal sequencing of prospectively collected stool samples. We examined the relationship between abundance of microbiota species or groups of related species and relapse/progression of disease during 2 years of follow-up time after allo-HCT by using cause-specific proportional hazards in a retrospective discovery-validation cohort study. Results Higher abundance of a bacterial group composed mostly of Eubacterium limosum in the validation set was associated with a decreased risk of relapse/progression of disease (hazard ratio [HR], 0.82 per 10-fold increase in abundance; 95% CI, 0.71 to 0.95; P = .009). When the patients were categorized according to presence or absence of this bacterial group, presence also was associated with less relapse/progression of disease (HR, 0.52; 95% CI, 0.31 to 0.87; P = .01). The 2-year cumulative incidences of relapse/progression among patients with and without this group of bacteria were 19.8% and 33.8%, respectively. These associations remained significant in multivariable models and were strongest among recipients of T-cell-replete allografts. Conclusion We found associations between the abundance of a group of bacteria in the intestinal flora and relapse/progression of disease after allo-HCT. These might serve as potential biomarkers or therapeutic targets to prevent relapse and improve survival after allo-HCT.
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Jonathan U
authors.initials: JU
authors.lastname: Peled
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Devlin
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Anna
authors.initials: A
authors.lastname: Staffas
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Melissa
authors.initials: M
authors.lastname: Lumish
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Raya
authors.initials: R
authors.lastname: Khanin
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Littmann
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Lilan
authors.initials: L
authors.lastname: Ling
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Satyajit
authors.initials: S
authors.lastname: Kosuri
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Molly
authors.initials: M
authors.lastname: Maloy
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: John B
authors.initials: JB
authors.lastname: Slingerland
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Katya F
authors.initials: KF
authors.lastname: Ahr
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Kori A
authors.initials: KA
authors.lastname: Porosnicu Rodriguez
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shono
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Ann E
authors.initials: AE
authors.lastname: Slingerland
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Melissa D
authors.initials: MD
authors.lastname: Docampo
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Sung
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Daniela
authors.initials: D
authors.lastname: Weber
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Amin M
authors.initials: AM
authors.lastname: Alousi
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Boglarka
authors.initials: B
authors.lastname: Gyurkocza
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Doris M
authors.initials: DM
authors.lastname: Ponce
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Juliet N
authors.initials: JN
authors.lastname: Barker
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Miguel-Angel
authors.initials: MA
authors.lastname: Perales
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Giralt
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Ying
authors.initials: Y
authors.lastname: Taur
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Eric G
authors.initials: EG
authors.lastname: Pamer
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Jenq
authors.affiliation: Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Marcel R M
authors.initials: MRM
authors.lastname: van den Brink
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D005260:Female; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006086:Graft vs Host Disease / Q000382:microbiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000378:metabolism / Q000382:microbiology* / Q000601:surgery*; D012189:Retrospective Studies; D014184:Transplantation, Homologous
chemical_list: D014408:Biomarkers, Tumor