title: Brain functional connectivity in lung cancer population: an exploratory study.
abstract: The present study aimed to explore the functional connectivity differences in Resting State Networks (RSNs) induced by cancer and chemotherapy in Lung Cancer (LC) patients using an Independent Component Analysis (ICA). Three matched groups of 15 LC patients following Chemotherapy (C+), 15 LC patients before Chemotherapy (C-) and 15 Healthy Controls (HC) were included. Analysis was performed using ICA and a multivariate pattern analysis (MVPA) to classify groups based on profiles of functional connectivity. We found significant differences in four of the RSN identified: Default Mode Network (DMN), Predominantly Left and Right Anterior Temporal Network, and Cerebellum Network. Whereas DMN showed decreased connectivity, the other RSNs exhibited increased connectivity in both LC groups compared to HC and in C+ in comparison to C-. MVPA discriminated significantly and accurately between all groups. Our study showed that disrupted functional connectivity associated with cancer and chemotherapy-induced cognitive deficits is not only related to DMN decreased connectivity abnormalities but also to an increased connectivity of other RSNs, suggesting a potential compensatory mechanism. Graphical abstract.
authors.affiliation: Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.|Neuro-Oncology Unit, Hospital Universitari de Bellvitge-ICO L'Hospitalet-IDIBELL, 08907, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Simó
authors.affiliation: Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.|Department of Basic Psychology, Campus Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Rifà-Ros
authors.affiliation: Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Vaquero
authors.affiliation: Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.|Department of Basic Psychology, Campus Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Ripollés
authors.affiliation: Neuro-Oncology Unit, Hospital Universitari de Bellvitge-ICO L'Hospitalet-IDIBELL, 08907, Barcelona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Cayuela
authors.affiliation: Radiation Oncology Department, Hospital Germans Trias i Pujol, ICO Badalona, 08916, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Jové
authors.affiliation: Lung Cancer Unit, Radiation Oncology Department, ICO L'Hospitalet, 08907, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Navarro
authors.affiliation: Lung Cancer Unit, Medical Oncology Department, ICO L'Hospitalet, 08907, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Cardenal
authors.affiliation: Neuro-Oncology Unit, Hospital Universitari de Bellvitge-ICO L'Hospitalet-IDIBELL, 08907, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Bruna
authors.affiliation: Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907, Barcelona, Spain. antoni.rodriguez@icrea.cat.|Department of Basic Psychology, Campus Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, 08907, Barcelona, Spain. antoni.rodriguez@icrea.cat.|Catalan Institution for Research and Advanced Studies, ICREA, 08010, Barcelona, Spain. antoni.rodriguez@icrea.cat.
authors.forename: Antoni
authors.initials: A
authors.lastname: Rodríguez-Fornells
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D009483:Neuropsychological Tests; D017671:Platinum Compounds / Q000009:adverse effects / Q000627:therapeutic use; D011446:Prospective Studies; D012146:Rest
chemical_list: D000970:Antineoplastic Agents; D017671:Platinum Compounds
keywords: Chemotherapy; Default mode network; Functional connectivity; Lung cancer; Resting-state functional magnetic resonance imaging