title: Terrylenediimide-Based Intrinsic Theranostic Nanomedicines with High Photothermal Conversion Efficiency for Photoacoustic Imaging-Guided Cancer Therapy.
abstract: Activatable theranostic nanomedicines involved in photothermal therapy (PTT) have received constant attention as promising alternatives to traditional therapies in clinic. However, the theranostic nanomedicines widely suffer from instability and complicated nanostructures, which hamper potential clinical applications. Herein, we demonstrated a terrylenediimide (TDI)-poly(acrylic acid) (TPA)-based nanomedicine (TNM) platform used as an intrinsic theranostic agent. As an exploratory paradigm in seeking biomedical applications, TDI was modified with poly(acrylic acid)s (PAAs), resulting in eight-armed, star-like TPAs composed of an outside hydrophilic PAA corona and an inner hydrophobic TDI core. TNMs were readily fabricated via spontaneous self-assembly. Without additional vehicle and cargo, the as-prepared TNMs possessed a robust nanostructure and high photothermal conversion efficiency up to approximately 41%. The intrinsic theranostic properties of TNMs for use in photoacoustic (PA) imaging by a multispectral optoacoustic tomography system and in mediating photoinduced tumor ablation were intensely explored. Our results suggested that the TNMs could be successfully exploited as intrinsic theranostic agents for PA imaging-guided efficient tumor PTT. Thus, these TNMs hold great potential for (pre)clinical translational development.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology , Beijing 100029, China.
authors.forename: Shaobo
authors.initials: S
authors.lastname: Zhang
authors.forename: Weisheng
authors.initials: W
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology , Beijing 100029, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.forename: Chan
authors.initials: C
authors.lastname: Li
authors.affiliation: University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Xing-Jie
authors.identifier: 0000-0002-4793-1705
authors.initials: XJ
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology , Beijing 100029, China.
authors.forename: Meizhen
authors.identifier: 0000-0001-8519-8578
authors.initials: M
authors.lastname: Yin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007094:Imides / Q000737:chemistry / Q000627:therapeutic use*; D007834:Lasers; D061986:MCF-7 Cells; D051379:Mice; D061088:Photoacoustic Techniques; D010789:Phototherapy; D013329:Structure-Activity Relationship; D000068936:Theranostic Nanomedicine
chemical_list: D000970:Antineoplastic Agents; D007094:Imides
keywords: photoacoustic imaging; photothermal therapy; self-assembly; terrylenediimides; theranostic nanomedicine