title: Expression of Vav3 protein and its prognostic value in patients with gastric cancer.
abstract: Vav3 is associated with tumor growth, apoptosis, invasion, metastasis and angiogenesis. In this study, we detected the expression of Vav3 in gastric cancer tissues, and explored its role in invasion, metastasis and prognosis of gastric cancer. Vav3, MMP-2, MMP-9, TIMP-1 and TIMP-2 in primary lesion and pericarcinous tissues were tested with Immunohistochemistry and Western blot. Results showed a higher expression of Vav3 in primary lesion than in pericarcinous tissue, and the expression of Vav3 was significantly correlated with MMP-2, MMP-9 and TIMP-1 in gastric cancer tissues. Overexpression of Vav3 was associated with poorer differentiation, advanced clinical stage, more significant infiltration depth, lymphatic metastasis, and perineural invasion. Results of Kaplan-Meier verified that overexpression of Vav3 was related to poorer prognosis and shorter survival time. Moreover, Cox proportional hazard model revealed that overexpression of Vav3 was an independent risk factor of prognosis for patients with gastric cancer. In all, we conclude that overexpression of Vav3 is an independent risk factor for prognosis of gastric cancer, and can be used as a prognostic indicator. This may be because that Vav3 could regulate genes which associated with the invasion and metastasis.
authors.affiliation: Third Department of Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
authors.forename: Bibo
authors.initials: B
authors.lastname: Tan
authors.affiliation: Third Department of Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050011, China. Electronic address: li_yong_hbth@126.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of General Surgery, Hebei General Hospital, Shijiazhuang, 050051, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Shi
authors.affiliation: Third Department of Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
authors.forename: Liqiao
authors.initials: L
authors.lastname: Fan
authors.affiliation: Third Department of Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Pathology, PLA Bethune International Peace Hospital, Shijiazhuang, 050000, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Third Department of Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Tan
authors.affiliation: Third Department of Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Third Department of Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Jia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D051567:Proto-Oncogene Proteins c-vav / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D051567:Proto-Oncogene Proteins c-vav; C560822:TIMP1 protein, human; C560823:TIMP2 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; C496621:VAV3 protein, human; D019716:Tissue Inhibitor of Metalloproteinase-2; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
keywords: Gastric cancer; Invasion; Metastasis; Prognosis; Vav3 protein