title: The Role of Semaphorin 3A in Bone Remodeling.
abstract: Bone remodeling occurs at the bone surface throughout adult life and associates bony quantity and quality. This process is a balance between the osteoblastic bone formation and osteoclastic bone resorption, which cross-talks together. Semaphorin 3A is a membrane-associated secreted protein and regarded as a diffusible axonal chemorepellent, which has been identified in the involvement of bone resorption and formation synchronously. However, the role of Semaphorin 3A in bone homeostasis and diseases remains elusive, in particular the association to osteoblasts and osteoclasts. In this review article, we summarize recent progress of Semaphorin 3A in the bone mass, homeostasis, and diseases and discuss the novel application of nerve-based bone regeneration. This will facilitate the understanding of Semaphorin 3A in skeletal biology and shed new light on the modulation and potential treatment in the bone disorders.
authors.affiliation: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu, China.
authors.forename: Zhenxia
authors.initials: Z
authors.lastname: Li
authors.affiliation: Program in Biological Sciences in Dental Medicine, Harvard School of Dental Medicine Boston, MA, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Hao
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, Sichuan University Chengdu, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Duan
authors.affiliation: Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Wu
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, Sichuan University Chengdu, China.
authors.forename: Zongke
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu, China.
authors.forename: Zhihe
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, Sichuan University Chengdu, China.
authors.forename: Shishu
authors.initials: S
authors.lastname: Huang
keywords: Semaphorin 3A; nerve innervation; osteoprotection; remodeling; skeleton