title: Carcinogenesis mechanisms of Fusobacterium nucleatum.
abstract: Transformed cells of cancers may be related to stromal cells, immune cells, and some bacteria such as Fusobacterium nucleatum. This review aimed to evaluate carcinogenesis mechanisms of Fusobacterium spp. in the oral cavity, pancreatic and colorectal cancers. These cancers are the three of the ten most prevalence cancer in the worldwide. Recent findings demonstrated that F. nucleatum could be considered as the risk factor for these cancers. The most important carcinogenesis mechanisms of F. nucleatum are chronic infection, interaction of cell surface molecules of these bacteria with immune system and stromal cells, immune evasion and immune suppression. However, there are some uncertainty carcinogenesis mechanisms about these bacteria, but this review evaluates almost all the known mechanisms. Well-characterized virulence factors of F. nucleatum such as FadA, Fap2, LPS and cell wall extracts may act as effector molecules in the shift of normal epithelial cells to tumor cells. These molecules may provide new targets, drugs, and strategies for therapeutic intervention.
authors.affiliation: Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Pourya
authors.initials: P
authors.lastname: Gholizadeh
authors.affiliation: Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hosein
authors.initials: H
authors.lastname: Eslami
authors.affiliation: Infectious and Tropical Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Kafilhs@tbzmed.ac.ir.
authors.forename: Hossein Samadi
authors.initials: HS
authors.lastname: Kafil
mesh_terms: D063646:Carcinogenesis; D015179:Colorectal Neoplasms / Q000382:microbiology; D016967:Fusobacterium nucleatum / Q000378:metabolism*; D006801:Humans; D009062:Mouth Neoplasms / Q000382:microbiology; D010190:Pancreatic Neoplasms / Q000382:microbiology; D012307:Risk Factors
keywords: Colorectal cancer; Fusobacterium nucleatum; Mechanisms; Oral cavity cancer; Pancreatic cancer