title: Redox Control of Mitochondrial Calcium Uptake.
abstract: Dong et al. (2017) establish how the mitochondrial Ca2+uniporter (MCU) integrates Ca2+and oxidative stress signals by identifying a cysteine residue that controls MCU channel activity, a mechanism causing mitochondrial Ca2+overload and cell death during oxidative stress.
authors.affiliation: Department of Cell Physiology and Metabolism, University of Geneva, 1, rue Michel-Servet, 1211 Geneva 4, Switzerland. Electronic address: nicolas.demaurex@unige.ch.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Demaurex
authors.affiliation: Department of Cell Physiology and Metabolism, University of Geneva, 1, rue Michel-Servet, 1211 Geneva 4, Switzerland.
authors.forename: Manon
authors.initials: M
authors.lastname: Rosselin
mesh_terms: D002118:Calcium; D015220:Calcium Channels / Q000737:chemistry*; D008928:Mitochondria; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D015220:Calcium Channels; D002118:Calcium
keywords: apoptosis; cell signaling; inflammation; ion channels; metabolism; mitochondria; oxidative stress