title: Drugs and Driving Research in Medicinal Drug Development.
abstract: Medicinal drugs that cause drowsiness and inattentiveness may impair driving. The FDA recently emphasized that standardized procedures for measuring drug effects on driving are needed as part of drug registration. Here, I provide an overview of a standardized on-the-road driving test that offers maximal drug sensitivity and uses a real-life outcome measure of driver impairment that is strongly associated with crash risk.
authors.affiliation: Department of Neuropsychology & Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands. Electronic address: j.ramaekers@maastrichtuniversity.nl.
authors.forename: J G
authors.initials: JG
authors.lastname: Ramaekers
mesh_terms: D000063:Accidents, Traffic / Q000517:prevention & control; D001288:Attention / Q000187:drug effects; D001334:Automobile Driving; D055808:Drug Discovery; D006801:Humans; D008004:Licensure; D012106:Research; D012894:Sleep Stages / Q000187:drug effects