title: Structure-symptom relationship with wide-area ultrasound scanning of knee osteoarthritis.
abstract: The aetiology of knee pain in osteoarthritis (OA) is heterogeneous and its relationship with structural changes and function is unclear. Our goal was to determine the prevalence of wide-area scanned ultrasound-defined knee OA structural features and their association with pain and functional impairment in 79 symptomatic and 63 asymptomatic subjects. All subjects underwent ultrasound knee wide-area scanning and the severity of articular cartilage degeneration, the presence and size of osteophytes, and meniscal extrusion were evaluated. Subjects filled in a self-administrated questionnaire on present knee pain, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) on clinical symptoms and function over the past week. Cartilage changes were the most prevalent followed by lateral meniscal extrusion, osteophytes and medial meniscal extrusion. The global femoral cartilage grade associated strongly with pain and the WOMAC index. Site-specifically, early medial cartilage changes and thinning in sulcus and lateral site were associated with symptoms. The presence of femoral lateral osteophytes was also associated with both outcomes. Using the novel wide-area ultrasound scanning technique, we were able to confirm the negative impact of femoral cartilage OA changes on clinical symptoms. Presence, not necessarily size, of lateral femoral osteophytes was also associated with increased pain and disability.
authors.affiliation: Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland.
authors.forename: Jana
authors.initials: J
authors.lastname: Podlipská
authors.affiliation: Department of Internal Medicine, Mikkeli Central Hospital, Mikkeli, Finland.
authors.forename: Juhani M
authors.initials: JM
authors.lastname: Koski
authors.affiliation: Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Kuopio, Finland.|Department of Physical and Rehabilitation Medicine, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Päivi
authors.initials: P
authors.lastname: Kaukinen
authors.affiliation: Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.|Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.|Center for Life Course Health Research, University of Oulu, Oulu, Finland.
authors.forename: Marianne
authors.initials: M
authors.lastname: Haapea
authors.affiliation: Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland.|Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.|Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.
authors.forename: Osmo
authors.initials: O
authors.lastname: Tervonen
authors.affiliation: Department of Physical and Rehabilitation Medicine, University of Helsinki, Finland.|Helsinki University Hospital, Helsinki, Finland.
authors.forename: Jari P
authors.initials: JP
authors.lastname: Arokoski
authors.affiliation: Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland.|Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.|Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.
authors.forename: Simo
authors.initials: S
authors.lastname: Saarakkala
mesh_terms: D000368:Aged; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008592:Menisci, Tibial / Q000000981:diagnostic imaging / Q000503:physiopathology; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012720:Severity of Illness Index; D013977:Tibia / Q000000981:diagnostic imaging / Q000503:physiopathology