title: Intensive care medicine research agenda on cardiac arrest.
abstract: Over the last 15 years, treatment of comatose post-cardiac arrest patients has evolved to include therapeutic strategies such as urgent coronary angiography with percutaneous coronary intervention (PCI), targeted temperature management (TTM)-requiring mechanical ventilation and sedation-and more sophisticated and cautious prognostication. In 2015, collaboration between the European Resuscitation Council (ERC) and the European Society for Intensive Care Medicine (ESICM) resulted in the first European guidelines on post-resuscitation care. This review addresses the major recent advances in the treatment of cardiac arrest, recent trials that have challenged current practice and the remaining areas of uncertainty.
authors.affiliation: School of Clinical Sciences, University of Bristol, Bristol, UK. jerry.nolan@nhs.net.|Anaesthesia and Intensive Care Medicine, Royal United Hospital, Bath, UK. jerry.nolan@nhs.net.
authors.forename: Jerry P
authors.identifier: http://orcid.org/0000-0003-3141-3812
authors.initials: JP
authors.lastname: Nolan
authors.affiliation: Pediatric Critical Care Medicine, Russell Raphaely Endowed Chair of Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, USA.|Anesthesiology and Critical Care Medicine, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Berg
authors.affiliation: Ambulance Victoria, Victoria, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Bernard
authors.affiliation: Department of Emergency Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
authors.forename: Bentley J
authors.initials: BJ
authors.lastname: Bobrow
authors.affiliation: Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Clifton W
authors.initials: CW
authors.lastname: Callaway
authors.affiliation: Department of Clinical Sciences Lund, Neurology, Skane University Hospital, Lund University, Lund, Sweden.
authors.forename: Tobias
authors.initials: T
authors.lastname: Cronberg
authors.affiliation: Department of Cardiology, Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands.
authors.forename: Rudolph W
authors.initials: RW
authors.lastname: Koster
authors.affiliation: Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Kudenchuk
authors.affiliation: University of Washington-Harborview Center for Prehospital Emergency Care, University of Washington, Seattle, WA, USA.
authors.forename: Graham
authors.initials: G
authors.lastname: Nichol
authors.affiliation: Critical Care Medicine, Warwick Medical School and Heart of England NHS Foundation Trust, University of Warwick, Coventry, CV4 7AL, UK.
authors.forename: Gavin D
authors.initials: GD
authors.lastname: Perkins
authors.affiliation: University of Washington, Seattle, WA, USA.
authors.forename: Tom D
authors.initials: TD
authors.lastname: Rea
authors.affiliation: Department of Anaesthesiology and Intensive Care, Catholic University School of Medicine, Largo Gemelli, 8, 00168, Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Sandroni
authors.affiliation: Anaesthesia and Intensive Care Medicine, North Bristol NHS Trust, Southmead Hospital, Bristol, BS10 5NB, UK.
authors.forename: Jasmeet
authors.initials: J
authors.lastname: Soar
authors.affiliation: Department of Anaesthesiology, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.|Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Kjetil
authors.initials: K
authors.lastname: Sunde
authors.affiliation: Medical ICU, Cochin Hospital (AP-HP), Paris-Cardiovascular-Research-Centre, INSERM U970 (Sudden Death Expertize Centre), Université Paris-Descartes-Sorbonne-Paris-Cité, Paris, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Cariou
mesh_terms: D035843:Biomedical Research; D016887:Cardiopulmonary Resuscitation / Q000193:education / Q000379:methods*; D003128:Coma / Q000628:therapy; D017023:Coronary Angiography / Q000379:methods*; D003422:Critical Care; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D018696:Neuroprotective Agents / Q000627:therapeutic use; D058687:Out-of-Hospital Cardiac Arrest / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D017063:Outcome Assessment, Health Care; D062645:Percutaneous Coronary Intervention / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D012121:Respiration, Artificial / Q000379:methods; D061665:Time-to-Treatment
chemical_list: D018696:Neuroprotective Agents
keywords: Advanced life support; Basic life support; Cardiac arrest; Cardiopulmonary resuscitation; Post-resuscitation care; Prognostication