title: Enhancement of Healing of Long Tubular Bone Defects in Rabbits Using a Mixture of Atelocollagen Gel and Bone Marrow Aspirate Concentrate.
abstract: We evaluated the bone-forming potential of a mixture of atelocollagen and bone marrow aspirate concentrate which was transplanted into bone defects. Radial shaft defects of about 10 mm in size were created in 30 New Zealand white rabbits. Ten rabbits in the control group were not treated further, 10 rabbits in the first experimental group (E1) received an atelocollagen injection, and 10 rabbits in the second experimental group (E2) received an injection of a mixture of atelocollagen and bone marrow aspirate concentrate. The groups were compared radiologically at 8 weeks. Osteogenesis in group E2 progressed more rapidly than that in the other groups, and osteogenesis in group E1 progressed faster than that in the control group. Thus, the administration of a mixture of atelocollagen and bone marrow aspirate concentrate in bone defects was found to enhance bone defect healing.
authors.affiliation: Department of Orthopedic Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, Catholic University, Uijeongbu-si, Republic of Korea.
authors.forename: Ho Youn
authors.initials: HY
authors.lastname: Park
authors.forename: Asode Ananthram
authors.initials: AA
authors.lastname: Shetty
authors.forename: Jang Mook
authors.initials: JM
authors.lastname: Kim
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Kim
authors.forename: Jae-Deog
authors.initials: JD
authors.lastname: Jang
authors.forename: Nam Yong
authors.initials: NY
authors.lastname: Choi
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Seok Jung
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D002118:Calcium / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D003094:Collagen / Q000494:pharmacology*; D003114:Colony-Forming Units Assay; D005782:Gels / Q000494:pharmacology*; D008863:Microspheres; D011817:Rabbits; D013396:Suction; D034421:Sus scrofa; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D005782:Gels; C059821:atelocollagen; D003094:Collagen; D000469:Alkaline Phosphatase; D002118:Calcium
keywords: Atelocollagen; Bone defect; Bone marrow aspirate concentrate; Delayed union; Osteogenesis