title: Recent Progress in the Design of Monodisperse, Sequence-Defined Macromolecules.
abstract: This review describes different synthetic strategies towards sequence-defined, monodisperse macromolecules, which are built up by iterative approaches and lead to linear non-natural polymer structures. The review is divided in three parts: solution phase-, solid phase-, and fluorous- and polymer-tethered approaches. Moreover, synthesis procedures leading to conjugated and non-conjugated macromolecules are considered and discussed in the respective sections. A major focus in the evaluation is the applicability of the different approaches in polymer chemistry. In this context, simple procedures for monomer and oligomer synthesis, overall yields, scalability, purity of the oligomers, and the achievable level of control (side-chains, backbone, stereochemistry) are important benchmarks.
authors.affiliation: Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry (IOC), Materialwissenschaftliches Zentrum für Energiesysteme (MZE), Geb. 30.48, Straße am Forum 7, 76131, Karlsruhe, Germany.
authors.forename: Susanne C
authors.initials: SC
authors.lastname: Solleder
authors.affiliation: Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry (IOC), Materialwissenschaftliches Zentrum für Energiesysteme (MZE), Geb. 30.48, Straße am Forum 7, 76131, Karlsruhe, Germany.
authors.forename: Rebekka V
authors.initials: RV
authors.lastname: Schneider
authors.affiliation: Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry (IOC), Materialwissenschaftliches Zentrum für Energiesysteme (MZE), Geb. 30.48, Straße am Forum 7, 76131, Karlsruhe, Germany.
authors.forename: Katharina S
authors.initials: KS
authors.lastname: Wetzel
authors.affiliation: Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry (IOC), Materialwissenschaftliches Zentrum für Energiesysteme (MZE), Geb. 30.48, Straße am Forum 7, 76131, Karlsruhe, Germany.
authors.forename: Andreas C
authors.initials: AC
authors.lastname: Boukis
authors.affiliation: Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry (IOC), Materialwissenschaftliches Zentrum für Energiesysteme (MZE), Geb. 30.48, Straße am Forum 7, 76131, Karlsruhe, Germany.
authors.forename: Michael A R
authors.initials: MAR
authors.lastname: Meier
mesh_terms: D002621:Chemistry / Q000639:trends*; D046911:Macromolecular Substances / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis*
chemical_list: D046911:Macromolecular Substances; D011108:Polymers
keywords: conjugated macromolecules; monodisperse; sequence-control; sequence-defined