title: [Advances in the Research of the Regulation of Chinese Traditional Medicine Monomer and Its Derivatives on Autophagy in Non-small Cell Lung Cancer].
abstract: The high morbidity and mortality of non-small cell lung cancer (NSCLC) did influence the quality of life of tumor patients world-wide. There is an urgent need to develop new therapies that have high anti-tumor activity and low toxicity side effects. It is widely accepted that autophagy can play diverse roles in carcinogenesis, such as induces pro-death of lung cancer cells or helps the escape from cell death, making it become a proper anticancer target. It's believed that various monomers of Chinese traditional medicine closely correlates to anti-NSCLC activities, and that even could affect the acquired multiple drug resistance (MDR). Furthermore, autophagy might be the underling mechanisms which could play a role as the candidate targets of natural active compounds. Recent studies of terpenoids, alkaloid, dietary polyphenols, saponins and other active ingredients that extracted from a large variety of herbs suggest that different monomer compounds could either regulate the activity of pro-death autophagy or influence the level of protective autophagy of NSCLC cells, thus changing their drug sensitivity and cell viability. This paper aims to give a systemic description of the latest advances about natural compounds and their derivatives that involved in tumorigenesis of NSCLC via inducing the autophagy.
authors.affiliation: Department of Cancer Biotherapy Center, the Third Affiliated Hospital of Kunming Medical University, Kunming 650500, China.
authors.forename: Meiyi
authors.initials: M
authors.lastname: Xiang
authors.affiliation: Department of Cancer Biotherapy Center, the Third Affiliated Hospital of Kunming Medical University, Kunming 650500, China.
authors.forename: Ruilei
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Cancer Biotherapy Center, the Third Affiliated Hospital of Kunming Medical University, Kunming 650500, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Cancer Biotherapy Center, the Third Affiliated Hospital of Kunming Medical University, Kunming 650500, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Song
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001343:Autophagy / Q000187:drug effects*; D063646:Carcinogenesis / Q000187:drug effects; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D008516:Medicine, Chinese Traditional / Q000379:methods*
chemical_list: D000972:Antineoplastic Agents, Phytogenic