title: Regenerating muscle with arginine methylation.
abstract: Protein arginine methyltransferase (PRMT) is a family of nine proteins catalyzing the methylation of arginine residues. They were recently shown to be essential for proper regeneration of skeletal muscles. However, the mechanisms triggering the methylation event, as well as how the methylated substrates regulate muscle stem cell function and fate decision remain to be determined. This point-of-view will discuss the recent findings on the specific role of PRMT1, CARM1/PRMT4, PRMT5, and PRMT7 in muscle stem cell fate guidance, and shed light on the future challenges which could help defining the therapeutic potential of PRMT inhibitors against muscular disorders and aging.
authors.affiliation: a Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital , Montréal , Québec , Canada.|b Departments of Oncology and Medicine , McGill University , Montréal , Québec , Canada.
authors.forename: Roméo S
authors.initials: RS
authors.lastname: Blanc
authors.affiliation: a Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital , Montréal , Québec , Canada.|b Departments of Oncology and Medicine , McGill University , Montréal , Québec , Canada.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Richard
mesh_terms: D000375:Aging / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001120:Arginine / Q000378:metabolism; D006801:Humans; D008745:Methylation; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000502:physiology*; D009135:Muscular Diseases / Q000378:metabolism / Q000473:pathology; D032446:Myoblasts / Q000378:metabolism* / Q000473:pathology; D011484:Protein-Arginine N-Methyltransferases; D012038:Regeneration
chemical_list: D009124:Muscle Proteins; D001120:Arginine; D011484:Protein-Arginine N-Methyltransferases
keywords: PRMT; PRMT1; PRMT7; arginine methylation; inhibitor; muscle regeneration; muscle stem cell