title: [Comparative Assessment of Effects of Free and Fixed Combinations of Hypotensive Drugs on Quality of Life of Patients With Arterial Hypertension of High and Very High Risk].
abstract: OBJECTIVE
  comparative assessment of effects of free and fixed combinations of hypotensive drugs on quality of life (QL) of patients with arterial hypertension (AH) of high and very high risk of cardiovascular complications.
  
  
  METHODS
  Study group comprised 120 patients (70% men, 30% women, age 45-65 years) with degree II (20.9%) and III (79.1%) A. Duration of AH was 10.6+/-2.89 years. Risk was high in 58 (48.3%), very high - in 62 (51.7%) patients. Patients were randomized into 3 groups with different second step therapy. Patients of group 1 received amlodipine + ramipril, group 2 - amlodipine + lisinopril, group 3 - fixed amlodipine/lisinopril combination. If necessary bisoprolol and indapamide were added at 3-rd and 4-th step, respectively. Assessment of QL was carried out prior to therapy and at the end of 14-th week of intervention by means of Short Form-36 (SF-36).
  
  
  RESULTS
  Use of fixed amlodipine/lisinopril combination in patients with AH with high and very high risk of cardiovascular complications compared with free combinations of amlodipine and lisinopril or ramipril was associated with statistically significant improvement of a number of QL parameters as assessed by SF-36 questionnaire: physical functioning, bodily pain, general health, social functioning, and mental health.
authors.affiliation: 1Regional clinical antitubercular clinic, Kursk, Russia; 2Kursk State Medical University, Kursk, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Gridina
authors.affiliation: 1Regional clinical antitubercular clinic, Kursk, Russia; 2Kursk State Medical University, Kursk, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Povetkin
mesh_terms: D017311:Amlodipine / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D017298:Bisoprolol / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000523:psychology; D007190:Indapamide / Q000627:therapeutic use; D017706:Lisinopril / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D017257:Ramipril / Q000627:therapeutic use; D011897:Random Allocation; D011795:Surveys and Questionnaires
chemical_list: D000959:Antihypertensive Agents; D017311:Amlodipine; D017706:Lisinopril; D007190:Indapamide; D017257:Ramipril; D017298:Bisoprolol