title: Green tea and its anti-angiogenesis effects.
abstract: The development of new blood vessels from a pre-existing vasculature (also known as angiogenesis) is required for many physiological processes including embryogenesis and post-natal growth. However, pathological angiogenesis is also a hallmark of cancer and many ischaemic and inflammatory diseases. The pro-angiogenic members of the VEGF family (vascular endothelial growth factor family), VEGF-A, VEGF-B, VEGF-C, VEGF-D and placental growth factor (PlGF), and the related receptors, VEGFR-1, VEGFR-2 and VEGFR-3 have a central and decisive role in angiogenesis. Indeed, they are the targets for anti-angiogenic drugs currently approved. Green tea (from the Camellia sinensis plant) is one of the most popular beverages in the world. It is able to inhibit angiogenesis by different mechanisms such as microRNAs (miRNAs). Green tea and its polyphenolic substances (like catechins) show chemo-preventive and chemotherapeutic features in various types of cancer and experimental models for human cancers. The tea catechins, including (-)-epigallocatechin-3-gallate (EGCG), have multiple effects on the cellular proteome and signalome. Note that the polyphenolic compounds from green tea are able to change the miRNA expression profile associated with angiogenesis in various cancer types. This review focuses on the ability of the green tea constituents to suppress angiogenesis signaling and it summarizes the mechanisms by which EGCG might inhibit the VEGF family. We also highlighted the miRNAs affected by green tea which are involved in anti-angiogenesis.
authors.affiliation: Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Bahman
authors.initials: B
authors.lastname: Rashidi
authors.affiliation: Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mehrnoush
authors.initials: M
authors.lastname: Malekzadeh
authors.affiliation: Department of Biosystems, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven - KULeuven, Kasteelpark Arenberg 30, B-3001 Heverlee, Belgium.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Goodarzi
authors.affiliation: Department of Molecular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
authors.forename: Aria
authors.initials: A
authors.lastname: Masoudifar
authors.affiliation: Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Mirzaeih911h@mums.ac.ir.
authors.forename: Hamed
authors.initials: H
authors.lastname: Mirzaei
mesh_terms: D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D013662:Tea / Q000737:chemistry*; D042442:Vascular Endothelial Growth Factors / Q000037:antagonists & inhibitors*
chemical_list: D035683:MicroRNAs; D013662:Tea; D042442:Vascular Endothelial Growth Factors; D002392:Catechin; C045651:epigallocatechin gallate
keywords: Angiogenesis; Epigallocatechin-3-gallate; Green tea; MicroRNA; VEGF