title: [Proprotein Convertase Subtilisin/Kexin-Type 9 (PCSK9) New Opportunities of Lipid-Lowering Therapy].
abstract: In the literature review covered issues opening protein-proprotein convertase, subtilisin/kexin-type9 (PCSK9), its modern terminology, the results of its biochemical, molecular and genetic studies, metabolic regulation, functions and clinical findings in the blood content ofPCSK9 in lipid disorders and clinical pharmacological studies of monoclonal antibodies to this protein for the correction of lipid metabolism of major interest for cardiology and lipidology.
authors.affiliation: Institute of Internal and Preventive Medicine, Novosibirsk, Russia.
authors.forename: K S
authors.initials: KS
authors.lastname: Astrakova
authors.affiliation: Institute of Internal and Preventive Medicine, Novosibirsk, Russia.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Ragino
authors.affiliation: Institute of Internal and Preventive Medicine, Novosibirsk, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Shakhtshneider
authors.affiliation: Institute of Internal and Preventive Medicine, Novosibirsk, Russia.
authors.forename: M I
authors.initials: MI
authors.lastname: Voevoda
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D058990:Molecular Targeted Therapy; D000071449:Proprotein Convertase 9 / Q000032:analysis / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D043484:Proprotein Convertases
chemical_list: D000911:Antibodies, Monoclonal; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases
keywords: coronary heart disease; lipid-lowering therapy; monoclonal antibodies; proprotein convertase; subtilisin/kexin-type 9 (PCSK9)