title: Serum reproductive hormone levels and ultrasound findings in female offspring after intracytoplasmic sperm injection: first results.
abstract: To compare reproductive hormone levels and antral follicle count in intracytoplasmic sperm injection (ICSI)-conceived offspring and peers born after spontaneous conception.
  
  
  
  Single-center study of the reproductive health at the age of 18-22 years in the worldwide oldest cohort of female ICSI offspring.
  
  
  
  University hospital.
  
  
  
  A longitudinally followed cohort of singleton women (n = 71) conceived by means of ICSI because of male infertility and a cross-sectionally recruited group of spontaneously conceived women of the same age (n = 81).
  
  
  
  None.
  
  
  
  Differences in serum reproductive hormone levels and ultrasound findings.
  
  
  
  Median levels of antimüllerian hormone (AMH), FSH, LH, and DHEAS were similar between ICSI women and their spontaneously conceived counterparts. Median E2levels in ICSI women taking hormonal contraceptives were higher compared with control women. A minority of ICSI women had AMH levels below the 5th or above the 95th percentile, and ICSI women were not more likely to have AMH levels below the 5th percentile or above the 95th percentile compared with control women. Mean follicle count per ovary was similar between the ICSI and control groups. Furthermore, a similar proportion of women had >19 follicles per ovary (ICSI: 20.9%; control: 20.0%). A strong positive correlation between AMH level and mean follicle count per ovary was found.
  
  
  
  In this cohort of 71 young adult women conceived by means of ICSI because of male infertility in their parents, antral follicle count and circulating reproductive hormone levels, including AMH, FSH, LH, and DHEAS, were found to be similar to results from peers born after spontaneous conception.
authors.affiliation: Center for Medical Genetics, Universitair Ziekenhuis Brussel, Brussels, Belgium. Electronic address: florence_belva@hotmail.com.
authors.forename: Florence
authors.initials: F
authors.lastname: Belva
authors.affiliation: Environment and Health/Youth Health Care, Department of Public Health and Primary Care, Leuven, Belgium.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Roelants
authors.affiliation: Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium.
authors.forename: Veerle
authors.initials: V
authors.lastname: Vloeberghs
authors.affiliation: Laboratory of Hormonology and Tumor Markers, Universitair Ziekenhuis Brussel, Brussels, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Schiettecatte
authors.affiliation: Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Evenepoel
authors.affiliation: Center for Medical Genetics, Universitair Ziekenhuis Brussel, Brussels, Belgium.
authors.forename: Maryse
authors.initials: M
authors.lastname: Bonduelle
authors.affiliation: Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium.
authors.forename: Michel
authors.initials: M
authors.lastname: de Vos
mesh_terms: D000293:Adolescent; D032721:Adult Children; D054304:Anti-Mullerian Hormone / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D005298:Fertility; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D042341:Gonadal Hormones / Q000097:blood*; D006785:Hospitals, University; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D006080:Ovarian Follicle / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D060728:Reproductive Health; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human; D042341:Gonadal Hormones; D019314:Dehydroepiandrosterone Sulfate; D054304:Anti-Mullerian Hormone; D007986:Luteinizing Hormone
keywords: ICSI; fertility; hormones; offspring; reproduction; women