title: Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants.
abstract: Cytokine polymorphisms may contribute to the prevalence of respiratory distress syndrome. The present study was done to investigate the frequency of interleukin- (IL-) 10 and tumor necrosis factor- (TNF-)αgene polymorphisms and their association with the risk of RDS in preterm infants. One-hundred and nineteen patients with RDS and 119 healthy preterm infants were enrolled. PCR restriction fragment length polymorphism was used to determine the frequency of IL-10 and TNF-αgenotypes at -1082 A and -308 A, respectively. One-hundred and nineteen out of 238 infants had RDS (50%). The age of the mothers and gestational age ranged 17-45 (mean: 28.6 ± 5.3) years and 24-34 (mean: 34.3 ± 2.38) weeks, respectively. Totally, 23 deaths were recorded in the RDS group. Incidence of TNF-α-308 A/A and TNF-α-308 G/A was 84% and 16%, respectively. TNF-a-308 G/G was not found in both groups. Prevalence of IL-10-1082 G/G and IL-10-1082 G/A variants was 65.5% and 34.5%, respectively. IL-10-1082 A/A was not found in both groups. The incidence of the allele G in the IL-10-1082 polymorphism was lower in RDS group (P< 0.05). We found that the risk of RDS was correlated to sex, gestational age, and IL-10-1082.
authors.affiliation: Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Abolfazl
authors.identifier: 0000-0002-2844-7133
authors.initials: A
authors.lastname: Khoshdel
authors.affiliation: Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Soleiman
authors.identifier: 0000-0001-8285-8681
authors.initials: S
authors.lastname: Kheiri
authors.affiliation: Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Omidvari
authors.affiliation: Cellular and Molecular Research Center, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Moradi
authors.affiliation: Subspecialty of Pediatrics, Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Hamidi
authors.affiliation: Department of Medical Genetics, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Teimori
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007234:Infant, Premature; D016753:Interleukin-10 / Q000235:genetics*; D007492:Iran; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology / Q000235:genetics*; D013501:Surface-Active Agents / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D055815:Young Adult
chemical_list: C508609:IL10 protein, human; D013501:Surface-Active Agents; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10