title: [Importance of diffusion imaging in liver metastases].
abstract: OBJECTIVE
  Detection and characterization of focal liver lesions.
  
  
  METHODS
  Due to its excellent soft tissue contrast, the availability of liver-specific contrast agents and the possibility of functional imaging, magnetic resonance imaging (MRI) is the method of choice for the evaluation of focal liver lesions.
  
  
  METHODS
  Diffusion-weighted imaging (DWI) enables generation of functional information about the microstructure of a tissue besides morphological information.
  
  
  METHODS
  In the detection of focal liver lesions DWI shows a better detection rate compared to T2w sequences and a slightly poorer detection rate compared to dynamic T1w sequences. In principle, using DWI it is possible to distinguish malignant from benign liver lesions and also to detect a therapy response at an early stage.
  
  
  RESULTS
  For both detection and characterization of focal liver lesions, DWI represents a promising alternative to the morphological sequences; however, a more detailed characterization with the use of further sequences should be carried out particularly for the characterization of solid benign lesions. For the assessment and prognosis of therapy response, DWI offers advantages compared to morphological sequences.
  
  
  CONCLUSIONS
  For the detection of focal liver lesions DWI is in principle sufficient. After visual detection of a solid liver lesion a more detailed characterization should be carried out using further sequences (in particular dynamic T1w sequences). The DWI procedure should be used for the assessment and prognosis of a therapy response.
authors.affiliation: Institut für Klinische Radiologie und Nuklearmedizin, Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim der Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland. philipp.riffel@umm.de.
authors.forename: P
authors.initials: P
authors.lastname: Riffel
authors.affiliation: Institut für Klinische Radiologie und Nuklearmedizin, Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim der Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.
authors.forename: S O
authors.initials: SO
authors.lastname: Schoenberg
authors.affiliation: Institut für Klinische Radiologie und Nuklearmedizin, Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim der Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Krammer
mesh_terms: D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D012680:Sensitivity and Specificity
keywords: Detection rate; Focal liver lesions; Liver imaging; MRI; Response to therapy