title: X-Linked Retinoschisis in Juveniles: Follow-Up by Optical Coherence Tomography.
abstract: Purpose.To explore the structural progression of X-linked retinoschisis (XLRS) in patients by using spectral-domain optical coherence tomography (SD-OCT).Design.Retrospective, observational study.Methods.Patients who were diagnosed with XLRS by genetic testing underwent comprehensive ophthalmological examinations from December 2014 to October 2016. Each eye was measured by SD-OCT using the same clinical protocol. A correlation between best-corrected visual acuity (VA) and SD-OCT measurements was observed.Results.Six patients demonstrated retinoschisis (12 eyes) and typical foveal cyst-like cavities (10 eyes) on SD-OCT images with a mean logMAR VA of 0.48. The median age was 7.5 years at the initial visit. Their foveal retinal thickness (516.9μm) and choroid thickness (351.4μm) decreased at a rate of 38.1 and 7.5μm, respectively, at the 10.5-month follow-up visit; however, there were no significant differences (P= 0.622 andP= 0.406, resp.). There was no significant correlation between VA, the foveal retinal thickness, and subfoveal choroid thickness.Conclusions.SD-OCT images for XLRS patients during the juvenile period revealed no significant changes in the fundus structure, including the foveal retinal thickness and choroid thickness within one-year follow-up. There was a lack of correlation between VA, foveal retinal thickness, and subfoveal choroid thickness.
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing Key Laboratory for the Diagnosis and Treatment of Retinal and Choroid Diseases, Beijing, China.
authors.forename: Qin-Rui
authors.initials: QR
authors.lastname: Hu
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing Key Laboratory for the Diagnosis and Treatment of Retinal and Choroid Diseases, Beijing, China.
authors.forename: Lv-Zhen
authors.initials: LZ
authors.lastname: Huang
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing Key Laboratory for the Diagnosis and Treatment of Retinal and Choroid Diseases, Beijing, China.
authors.forename: Xiao-Li
authors.identifier: 0000-0001-8020-5513
authors.initials: XL
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing Key Laboratory for the Diagnosis and Treatment of Retinal and Choroid Diseases, Beijing, China.
authors.forename: Hui-Ka
authors.initials: HK
authors.lastname: Xia
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing Key Laboratory for the Diagnosis and Treatment of Retinal and Choroid Diseases, Beijing, China.
authors.forename: Tian-Qi
authors.initials: TQ
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, Peking University People's Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing Key Laboratory for the Diagnosis and Treatment of Retinal and Choroid Diseases, Beijing, China.
authors.forename: Xiao-Xin
authors.identifier: 0000-0002-5161-9458
authors.initials: XX
authors.lastname: Li
mesh_terms: D002648:Child; D002675:Child, Preschool; D002829:Choroid / Q000000981:diagnostic imaging*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012160:Retina / Q000000981:diagnostic imaging*; D041441:Retinoschisis / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence