title: Associations of central aortic pressure and brachial blood pressure with flow mediated dilatation in apparently healthy Japanese men: The Circulatory Risk in Communities Study (CIRCS).
abstract: Endothelial dysfunction is considered the first stage in the development of atherosclerosis and cardiovascular disease, and brachial flow-mediated dilation (FMD) is a measure of endothelial function. It is uncertain which of central systolic aortic pressure (CAP) or brachial systolic blood pressure (SBP) is more strongly associated with FMD. Therefore, we examined the correlations of CAP and SBP with FMD in Japanese men.
  
  
  
  The study subjects comprised 507 male volunteers aged 30-79 years that were residents in two communities under the Circulatory Risk in Communities Study (CIRCS) between 2013 and 2015. The low percent change of FMD (%FMD) ≤5.0%, after 5 min of reactive hyperemia evaluated by the brachial artery diameter, was used to assess endothelial dysfunction. Values of CAP and SBP were divided into tertiles, with the lowest tertile used as a reference.
  
  
  
  After adjustment for cardiovascular risk factors, the multivariable odds ratio (95% CI) of low FMD for the highest versus lowest tertile of CAP was 1.5 (0.9-2.6) for total subjects and 1.4 (0.5-3.8) for those with, and 2.4 (1.2-4.8) for those without antihypertensive medication use. The corresponding odd ratios for the highest versus lowest tertile of SBP were 0.9 (0.5-1.5), 0.8 (0.3-2.2), and 1.3 (0.7-2.5), respectively.
  
  
  
  Higher CAP levels were associated with low FMD for men without antihypertensive medication, but such an association was not found for SBP levels.
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan.
authors.forename: Keyang
authors.initials: K
authors.lastname: Liu
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan.
authors.forename: Renzhe
authors.initials: R
authors.lastname: Cui
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan; Department of Public Health and Preventive Medicine, Minia University, Egypt.
authors.forename: Ehab S
authors.initials: ES
authors.lastname: Eshak
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan.
authors.forename: Meishan
authors.initials: M
authors.lastname: Cui
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan.
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Dong
authors.affiliation: Osaka Center for Cancer, Cardiovascular Disease Prevention, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kiyama
authors.affiliation: Osaka Center for Cancer, Cardiovascular Disease Prevention, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Okada
authors.affiliation: Osaka Center for Cancer, Cardiovascular Disease Prevention, Japan; Tokyo Metropolitan Institute of Gerontology, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kitamura
authors.affiliation: Department of Public Health, Dokkyo Medical University, School of Medicine, Japan.
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Umesawa
authors.affiliation: Departments of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yamagishi
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Imano
authors.affiliation: Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohira
authors.affiliation: Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan. Electronic address: iso@pbhel.med.osaka-u.ac.jp.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001011:Aorta / Q000503:physiopathology*; D062186:Arterial Pressure / Q000187:drug effects; D050197:Atherosclerosis / Q000175:diagnosis / Q000503:physiopathology*; D001916:Brachial Artery / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D007564:Japan; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012039:Regional Blood Flow; D012307:Risk Factors; D012737:Sex Factors; D014664:Vasodilation / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents
keywords: Central aortic pressure; Cross sectional study; Endothelial function; Japanese men