title: Granulocyte transfusions in the management of invasive fungal infections.
abstract: Granulocyte transfusions have a long history of being used in patients with neutropenia or neutrophil dysfunction to prevent and treat invasive fungal infections. However, there are limited and conflicting data concerning its clinical effectiveness, considerable variations in current granulocyte transfusion practices, and uncertainties about its benefit as an adjunct to modern antifungal therapy. In this review, we provide an overview on granulocyte transfusions and summarize the evidence on their role in the prevention and treatment of invasive fungal infections.
authors.affiliation: Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA.
authors.forename: Kamille A
authors.identifier: 0000-0001-8152-804X
authors.initials: KA
authors.lastname: West
authors.affiliation: Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD, USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Gea-Banacloche
authors.affiliation: Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA.
authors.forename: David
authors.initials: D
authors.lastname: Stroncek
authors.affiliation: Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.
authors.forename: Sameer S
authors.initials: SS
authors.lastname: Kadri
mesh_terms: D046148:Donor Selection; D019317:Evidence-Based Medicine / Q000379:methods; D006098:Granulocytes / Q000637:transplantation*; D006801:Humans; D000072742:Invasive Fungal Infections / Q000097:blood / Q000628:therapy*; D017708:Leukocyte Transfusion / Q000009:adverse effects / Q000379:methods*; D009504:Neutrophils / Q000502:physiology
keywords: fungal infection; granulocytes; leukapheresis; neutropenia; transfusions