title: A Potential Role ofSalmonellaInfection in the Onset of Inflammatory Bowel Diseases.
abstract: Inflammatory bowel disease (IBD) includes a set of pathologies that result from a deregulated immune response that may affect any portion of the gastrointestinal tract. The most prevalent and defined forms of IBD are Crohn's disease and ulcerative colitis. Although the etiology of IBD is not well defined, it has been suggested that environmental and genetic factors contribute to disease development and that the interaction between these two factors can trigger the pathology. Diet, medication use, vitamin D status, smoking, and bacterial infections have been proposed to influence or contribute to the onset or development of the disease in susceptible individuals. The infection with pathogenic bacteria is a key factor that can influence the development and severity of this disease. Here, we present a comprehensive review of studies performed in human and mice susceptible to IBD, which supports the notion that infection with bacterial pathogens, such asSalmonella, could promote the onset of IBD due to permanent changes in the intestinal microbiota, disruption of the epithelial barrier and alterations of the intestinal immune response after infection.
authors.affiliation: Facultad de Ciencias Biológicas, Departamento de Genética Molecular y Microbiología, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile , Santiago , Chile.
authors.forename: Bárbara M
authors.initials: BM
authors.lastname: Schultz
authors.affiliation: Facultad de Ciencias Biológicas, Departamento de Genética Molecular y Microbiología, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile , Santiago , Chile.
authors.forename: Carolina A
authors.initials: CA
authors.lastname: Paduro
authors.affiliation: Facultad de Ciencias Biológicas, Departamento de Genética Molecular y Microbiología, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile , Santiago , Chile.
authors.forename: Geraldyne A
authors.initials: GA
authors.lastname: Salazar
authors.affiliation: Facultad de Ciencias Biológicas, Departamento de Genética Molecular y Microbiología, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile , Santiago , Chile.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Salazar-Echegarai
authors.affiliation: Facultad de Ciencias Biológicas, Departamento de Genética Molecular y Microbiología, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile , Santiago , Chile.
authors.forename: Valentina P
authors.initials: VP
authors.lastname: Sebastián
authors.affiliation: Facultad de Ciencias Biológicas y Facultad de Medicina, Departamento de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Universidad Andrés Bello , Santiago , Chile.
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Riedel
authors.affiliation: Facultad de Ciencias Biológicas, Departamento de Genética Molecular y Microbiología, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile; Facultad de Medicina, Departamento de Endocrinología, Pontificia Universidad Católica de Chile, Santiago, Chile; INSERM, UMR 1064, Nantes, France.
authors.forename: Alexis M
authors.initials: AM
authors.lastname: Kalergis
authors.affiliation: Facultad de Medicina, Departamento de Gastroenterología, Pontificia Universidad Católica de Chile , Santiago , Chile.
authors.forename: Manuel
authors.initials: M
authors.lastname: Alvarez-Lobos
authors.affiliation: Facultad de Ciencias Biológicas, Departamento de Genética Molecular y Microbiología, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile; INSERM, UMR 1064, Nantes, France.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Bueno
keywords: Crohn’s disease; Salmonella enterica serovar Typhimurium; gut microbiota; inflammatory bowel disease; innate immune response; ulcerative colitis; virulence factors