title: Antiretroviral therapy in HIV-infected adolescents: clinical and pharmacologic challenges.
abstract: With the currently available combined antiretroviral therapy regimens, durable suppression of viral replication, preservation of immune function and normalizing life expectancy, are all becoming achievable goals. Teenagers and young adults living with HIV present unique clinical and pharmacologic challenges to optimizing antiretroviral treatment outcomes. Areas covered: In this expert review of the topic, we examine recent clinical trial data and draw on our program's 25 year experience working with both perinatally and behaviorally HIV infected adolescents. Expert commentary: In order to be effective, the antiretrovirals we provide must be combined with multidisciplinary interventions and ongoing socio-behavioral support to ensure treatment adherence and prevent the emergence of viral resistance.
authors.affiliation: a Jacobi Medical Center, Department of Pediatrics, Division of Infectious Diseases , Albert Einstein College of Medicine , Bronx , NY , USA.
authors.forename: Joanna
authors.initials: J
authors.lastname: Dobroszycki
authors.affiliation: b Montefiore Medical Center , Department of Pediatrics, Division of Infectious Diseases , Bronx , NY , USA.
authors.forename: Philip
authors.initials: P
authors.lastname: Lee
authors.affiliation: c Jacobi Medical Center, Department of Pediatrics, Division of Adolescent Medicine , Albert Einstein College of Medicine , Bronx , NY , USA.
authors.forename: Dina L
authors.initials: DL
authors.lastname: Romo
authors.affiliation: a Jacobi Medical Center, Department of Pediatrics, Division of Infectious Diseases , Albert Einstein College of Medicine , Bronx , NY , USA.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rosenberg
authors.affiliation: d Jacobi Medical Center, Department of Pediatrics, Division of Allergy-Immunology , Albert Einstein College of Medicine , Bronx , NY , USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Wiznia
authors.affiliation: a Jacobi Medical Center, Department of Pediatrics, Division of Infectious Diseases , Albert Einstein College of Medicine , Bronx , NY , USA.
authors.forename: Jacobo
authors.initials: J
authors.lastname: Abadi
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D033183:Interdisciplinary Communication; D008017:Life Expectancy; D055118:Medication Adherence; D016896:Treatment Outcome; D014779:Virus Replication / Q000187:drug effects; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents
keywords: Adolescents; HIV infection; HIV pharmacology; adherence; antiretoviral therapy; perinatal HIV infection