title: The Development of a Palladium-Catalyzed Tandem Addition/Cyclization for the Construction of Indole Skeletons.
abstract: A palladium-catalyzed tandem addition/cyclization of 2-(2-aminoaryl)acetonitriles with arylboronic acids has been developed for the first time, achieving a new strategy for direct construction of indole skeletons. This system shows good functional group tolerance and remarkable chemoselectivity. In particular, the halogen (e.g., bromo and iodo) substituents are amenable to further synthetic elaborations thereby broadening the diversity of the products. Preliminary mechanistic experiments indicate that this transformation involves sequential nucleophilic addition followed by an intramolecular cyclization.
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, China.
authors.forename: Shuling
authors.initials: S
authors.lastname: Yu
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, China.
authors.forename: Linjun
authors.initials: L
authors.lastname: Qi
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Hu
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, China.
authors.forename: Julin
authors.initials: J
authors.lastname: Gong
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, China.
authors.forename: Tianxing
authors.initials: T
authors.lastname: Cheng
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, China.
authors.forename: Qingzong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, China.
authors.forename: Jiuxi
authors.identifier: 0000-0001-6666-9813
authors.initials: J
authors.lastname: Chen
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, China.
authors.forename: Huayue
authors.identifier: 0000-0003-3431-561X
authors.initials: H
authors.lastname: Wu