title: Internal dosimetry for radioembolization therapy with Yttrium-90 microspheres.
abstract: The absorbed doses in the liver and adjacent viscera in Yttrium-90 radioembolization therapy for metastatic liver lesions are not well-documented. We sought for a clinically practical way to determine the dosimetry of this advent treatment. Six different female XCAT BMIs and seven different male XCAT BMIs were generated. Using Monte Carlo GATE code simulation, the total of 100MBq90Y was deposited uniformly in the source organ, liver. Self-irradiation and absorbed doses in lung, kidney and bone marrow were calculated. The mean energy of Yittrium-90 (i.e., 0.937 MeV) was used. The S-values and equivalent doses in target organs were estimated. The dose absorbed in the liver was between 84 and 53 Gy and below the target of 80 to 150 Gy. The absorbed dose in the bone marrow, lungs, and kidneys are very low and below 0.1 , 0.4, and 0.5 Gy respectively. Our study indicates that larger activities than the conventional dose of 3 GBq may be both required and safe. Further confirmations in clinical settings are needed.
authors.affiliation: Department of Nuclear Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Fallahpoor
authors.affiliation: Department of Nuclear Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mehrshad
authors.initials: M
authors.lastname: Abbasi
authors.affiliation: Department of Medical Physics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Ali Asghar
authors.initials: AA
authors.lastname: Parach
authors.affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, 75235, USA.
authors.forename: Faraz
authors.initials: F
authors.lastname: Kalantari
mesh_terms: D001853:Bone Marrow / Q000528:radiation effects; D001918:Brachytherapy / Q000379:methods; D004621:Embolization, Therapeutic; D006801:Humans; D007668:Kidney / Q000528:radiation effects; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D008168:Lung / Q000528:radiation effects; D008863:Microspheres; D009010:Monte Carlo Method; D058958:Organs at Risk / Q000528:radiation effects*; D011874:Radiometry / Q000379:methods*; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes
keywords: Yttrium-90; dosimetry; microsphere