title: Stroke Related to Transcatheter Heart Valve Thrombosis.
abstract: Non-obstructive transcatheter heart valve (THV) thrombosis as a potential mechanism after stroke after transapical transcatheter aortic valve replacement (TAVR) is demonstrated by the present case report. By performing cardiac computed tomography (CT) in addition to standard transthoracic echocardiography (TTE) follow up after TAVR, it has been shown recently that non-obstructive THV thrombosis may be more common than previously anticipated. However, the clinical implications of non-obstructive THV thrombosis remain unclear. In the present patient, post-TAVR TTE and transeophageal echocardiography demonstrated normal THV function, and showed no evidence of THV thrombosis. In contrast, cardiac CT revealed findings consistent with THV thrombosis. The patient subsequently developed acute ischemic stroke that was treated with thrombolysis. Follow up cardiac CT and echocardiography demonstrated complete THV thrombus resolution.
authors.affiliation: Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark,. Electronic correspondence: nh@dadlnet.dk.
authors.forename: Nicolaj C
authors.initials: NC
authors.lastname: Hansson
authors.affiliation: Department of Radiology and Divisionof Cardiology, St. Paul´s Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Jonathon
authors.initials: J
authors.lastname: Leipsic
authors.affiliation: Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark.
authors.forename: Tina
authors.initials: T
authors.lastname: Leetmaa
authors.affiliation: Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark.
authors.forename: Ulrik M
authors.initials: UM
authors.lastname: Mortensen
authors.affiliation: Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark.
authors.forename: Henning R
authors.initials: HR
authors.lastname: Andersen
authors.affiliation: Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark.
authors.forename: Jesper M
authors.initials: JM
authors.lastname: Jensen
authors.affiliation: Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark.
authors.forename: Bjarne L
authors.initials: BL
authors.lastname: Nørgaard
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000601:surgery; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000209:etiology*; D017548:Echocardiography, Transesophageal; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D061330:Multidetector Computed Tomography; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D065467:Transcatheter Aortic Valve Replacement / Q000009:adverse effects*