title: Pseudomonas aeruginosaBiofilm, a Programmed Bacterial Life for Fitness.
abstract: A biofilm is a community of microbes that typically inhabit on surfaces and are encased in an extracellular matrix. Biofilms display very dissimilar characteristics to their planktonic counterparts. Biofilms are ubiquitous in the environment and influence our lives tremendously in both positive and negative ways.Pseudomonas aeruginosais a bacterium known to produce robust biofilms.P. aeruginosabiofilms cause severe problems in immunocompromised patients, including those with cystic fibrosis or wound infection. Moreover, the unique biofilm properties further complicate the eradication of the biofilm infection, leading to the development of chronic infections. In this review, we discuss the history of biofilm research and general characteristics of bacterial biofilms. Then, distinct features pertaining to each stage ofP. aeruginosabiofilm development are highlighted. Furthermore, infections caused by biofilms on their own or in association with other bacterial species (i.e., multispecies biofilms) are discussed in detail.
authors.affiliation: Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.|Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
authors.forename: Keehoon
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.|Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.|Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
authors.forename: Sang Sun
authors.initials: SS
authors.lastname: Yoon
mesh_terms: D018441:Biofilms / Q000254:growth & development*; D060085:Coinfection; D003550:Cystic Fibrosis / Q000382:microbiology; D056084:Genetic Fitness; D006801:Humans; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000254:growth & development / Q000502:physiology*; D053038:Quorum Sensing
keywords: Biofilm; Pseudomonas aeruginosa; biofilm development; biofilm infections; multi-species biofilm