title: Dephasing and diffusion on the alveolar surface.
abstract: We propose a surface model of spin dephasing in lung tissue that includes both susceptibility and diffusion effects to provide a closed-form solution of the Bloch-Torrey equation on the alveolar surface. The nonlocal susceptibility effects of the model are validated against numerical simulations of spin dephasing in a realistic lung tissue geometry acquired from synchotron-based μCT data sets of mouse lung tissue, and against simulations in the well-known Wigner-Seitz model geometry. The free induction decay is obtained in dependence on microscopic tissue parameters and agrees very well with in vivo lung measurements at 1.5 Tesla to allow a quantification of the local mean alveolar radius. Our results are therefore potentially relevant for the clinical diagnosis and therapy of pulmonary diseases.
authors.affiliation: German Cancer Research Center - DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.|Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
authors.forename: L R
authors.initials: LR
authors.lastname: Buschle
authors.affiliation: German Cancer Research Center - DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.|Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
authors.forename: F T
authors.initials: FT
authors.lastname: Kurz
authors.affiliation: University of Würzburg, Department of Experimental Physics 5, Am Hubland, 97074 Würzburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Kampf
authors.affiliation: University of Heidelberg, Department of Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.|University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC), Member of German Center for Lung Research (DZL), Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.
authors.forename: W L
authors.initials: WL
authors.lastname: Wagner
authors.affiliation: University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC), Member of German Center for Lung Research (DZL), Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.|University of Heidelberg, Department of Translational Pulmonology, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Duerr
authors.affiliation: University of Heidelberg, Department of Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.|University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC), Member of German Center for Lung Research (DZL), Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Stiller
authors.affiliation: University of Heidelberg, Department of Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.|University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC), Member of German Center for Lung Research (DZL), Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Konietzke
authors.affiliation: University of Heidelberg, Department of Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Wünnemann
authors.affiliation: University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC), Member of German Center for Lung Research (DZL), Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.|University of Heidelberg, Department of Translational Pulmonology, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.
authors.forename: M A
authors.initials: MA
authors.lastname: Mall
authors.affiliation: University of Heidelberg, Department of Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.|University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC), Member of German Center for Lung Research (DZL), Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.
authors.forename: M O
authors.initials: MO
authors.lastname: Wielpütz
authors.affiliation: German Cancer Research Center - DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
authors.forename: H P
authors.initials: HP
authors.lastname: Schlemmer
authors.affiliation: German Cancer Research Center - DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.|Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
authors.forename: C H
authors.initials: CH
authors.lastname: Ziener
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004058:Diffusion; D006801:Humans; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D011650:Pulmonary Alveoli / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism*; D055114:X-Ray Microtomography