title: Are intratympanic corticosteroids effective for Ménières disease?
abstract: Ménières disease affects the inner ear and its main symptoms are vertigo, hearing loss and fluctuating aural symptoms. Nowadays, there are many therapeutic alternatives, being the use of intratympanic corticosteroids one that has become popular. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple databases. We identified four systematic reviews including 15 studies overall, of which seven were randomized trials. We extracted data and generated a summary of findings table using the GRADE approach. We concluded intratympanic corticosteroids probably do not decrease tinnitus, and might not decrease vertigo, hearing loss or aural fullness sensation in Ménières disease. Intratympanic corticosteroids probably do not cause important adverse effects.
authors.affiliation: Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. Email: angelesbaezaa@gmail.com. Address: Facultad de Medicina, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago Centro, Chile.
authors.forename: Ángela
authors.initials: Á
authors.lastname: Chuang-Chuang
authors.affiliation: Proyecto Epistemonikos, Santiago, Chile; Departamento de Otorrinolaringología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: María A
authors.initials: MA
authors.lastname: Baeza
mesh_terms: D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects; D034381:Hearing Loss / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D000069555:Injection, Intratympanic; D008575:Meniere Disease / Q000188:drug therapy* / Q000503:physiopathology; D016032:Randomized Controlled Trials as Topic; D014012:Tinnitus / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome; D014717:Vertigo / Q000188:drug therapy / Q000209:etiology
chemical_list: D005938:Glucocorticoids