title: Glioactive ATP controls BDNF recycling in cortical astrocytes.
abstract: We have recently reported that long-term memory retention requires synaptic glia for proBDNF uptake and recycling. Through the recycling course, glial cells release endocytic BDNF, a mechanism that is activated in response to glutamateviaAMPA and mGluRI/II receptors. Cortical astrocytes express receptors for many different transmitters suggesting for a complex signaling controlling endocytic BDNF secretion. Here, we demonstrated that the extracellular nucleotide ATP, activating P2X and P2Y receptors, regulates endocytic BDNF secretion in cultured astrocytes. Our data indicate that distinct glioactive molecules can participate in BDNF glial recycling and suggest that cortical astrocytes contributing to neuronal plasticity can be influenced by neurotransmitters in tune with synaptic needs.
authors.affiliation: Centre for Integrative Biology (CIBIO), University of Trento , Povo (TN), Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Vignoli
authors.affiliation: Centre for Integrative Biology (CIBIO), University of Trento, Povo (TN), Italy; European Brain Research Institute (EBRI)-Rita Levi-Montalcini, Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Canossa
keywords: calcium; glial network; gliotransmission; neurotrophins; synaptic plasticity