title: Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF.
abstract: Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays.IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.
authors.affiliation: Department of Experimental Medical Science, Lund University, Lund, Sweden. abraham.roos@astrazeneca.com.|Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. abraham.roos@astrazeneca.com.|AstraZeneca R&D Gothenburg, Respiratory, Inflammation and Autoimmunity, Innovative Medicines, Pepparedsleden 1, 431 83, Mölndal, Sweden. abraham.roos@astrazeneca.com.
authors.forename: Abraham B
authors.initials: AB
authors.lastname: Roos
authors.affiliation: Department of Experimental Medical Science, Lund University, Lund, Sweden.
authors.forename: Michiko
authors.initials: M
authors.lastname: Mori
authors.affiliation: Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.|Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: Harpreet K
authors.initials: HK
authors.lastname: Gura
authors.affiliation: Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Lorentz
authors.affiliation: Department of Respiratory Medicine and Allergology, Lund University, Lund, Sweden.
authors.forename: Leif
authors.initials: L
authors.lastname: Bjermer
authors.affiliation: Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.|Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: Hans Jürgen
authors.initials: HJ
authors.lastname: Hoffmann
authors.affiliation: Department of Experimental Medical Science, Lund University, Lund, Sweden.
authors.forename: Jonas S
authors.initials: JS
authors.lastname: Erjefält
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.|Department of Medicine, Firestone Institute of Respiratory Health at St. Joseph's Health Care, Hamilton, ON, Canada.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Stampfli
mesh_terms: D000368:Aged; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism*; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000276:immunology*; D018123:Receptors, Interleukin / Q000276:immunology*; D053722:Receptors, Interleukin-17 / Q000276:immunology*; D015854:Up-Regulation / Q000276:immunology; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology*
chemical_list: C109985:IL17RA protein, human; C448419:IL17RC protein, human; D018123:Receptors, Interleukin; D053722:Receptors, Interleukin-17; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2