title: Smoking, APOE Genotype, and Cognitive Decline: The Rotterdam Study.
abstract: The association of smoking with preclinical cognitive decline remains unclear and may be modified by the APOEɛ4 genotype. In 5,705 participants (mean age: 63.9±9.1 years; 57.4% women) from the population-based Rotterdam Study, we investigated the relationship between smoking and cognitive decline over a 5.5-year period and examined potential effect modification by APOEɛ4 genotype. We found that current smoking was related to decline in global cognition [difference compared to never smoking: -0.06 (95% C.I.-0.10;-0.01)], as well as decline on specific cognitive tests including the Letter Digit Substitution Task, the 15-Word Learning Test, and the Purdue Pegboard. We found no evidence for effect modification by APOEɛ4 genotype on this relation.
authors.affiliation: Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Robin
authors.initials: R
authors.lastname: Wingbermühle
authors.affiliation: Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Ke-Xin
authors.initials: KX
authors.lastname: Wen
authors.affiliation: Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.|Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Wolters
authors.affiliation: Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.|Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.|Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: M Arfan
authors.initials: MA
authors.lastname: Ikram
authors.affiliation: Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.|Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Daniel
authors.initials: D
authors.lastname: Bos
mesh_terms: D000368:Aged; D053327:Apolipoprotein E4 / Q000235:genetics*; D003071:Cognition; D060825:Cognitive Dysfunction / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012907:Smoking / Q000453:epidemiology* / Q000235:genetics* / Q000523:psychology
chemical_list: D053327:Apolipoprotein E4
keywords: APOEɛ4 genotype; cognitive decline; epidemiology; smoking