title: High serum resistin levels are associated with peripheral artery disease in the hypertensive patients.
abstract: Hypertension is a risk factor for peripheral arterial disease (PAD). Subjects with PAD are at increased risk of future cardiovascular (CV) events. Resistin is involved in the pathological processes of CV diseases. The aim of this study is to investigate whether resistin level is correlated with PAD in hypertensive patients.
  
  
  
  One hundred and twenty-four hypertensive patients were enrolled in this study. Ankle-brachial index (ABI) values were measured using the automated oscillometric method. An ABI value < 0.9 defined the low ABI group. Anthropometric analysis with waist circumference and body mass index, and fasting serum levels of blood urea nitrogen, creatinine, glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total calcium, phosphorus, and high-sensitivity C-reactive protein (hs-CRP) were measured using standard enzymatic automated methods. Serum levels of human resistin were determined using a commercially available enzyme immunoassay.
  
  
  
  Eighteen hypertensive patients (14.5%) were included in the low ABI group. Hypertensive patients in the low ABI group were older (p = 0.043) and had higher serum creatinine (p < 0.001), high-sensitivity C-reactive protein (hs-CRP; p = 0.013), and resistin (p < 0.001) levels but a lower estimated glomerular filtration rate (p = 0.002) than patients in the normal ABI group. After the adjustment for factors that were significantly associated with PAD on multivariate logistic regression analysis, serum resistin (odds ratio [OR], 1.176; 95% confidence interval [CI], 1.028-1.345; p = 0.018) was also an independent predictor of PAD in hypertensive patients.
  
  
  
  A high serum resistin level is an independent predictor of PAD in hypertensive patients.
authors.affiliation: Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.|School of Medicine, Tzu Chi University, Hualien, Taiwan.
authors.forename: Bang-Gee
authors.initials: BG
authors.lastname: Hsu
authors.affiliation: Department of Nursing, Tzu Chi University of Science and Technology, Hualien, Taiwan.
authors.forename: Chung-Jen
authors.initials: CJ
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Buddhist Tzu Chi General Hospital, No. 707, Section 3, Chung-Yang Road, Hualien, 97002, Taiwan.
authors.forename: Chiu-Fen
authors.initials: CF
authors.lastname: Yang
authors.affiliation: Division of Cardiology, Buddhist Tzu Chi General Hospital, No. 707, Section 3, Chung-Yang Road, Hualien, 97002, Taiwan.
authors.forename: Yu-Chih
authors.initials: YC
authors.lastname: Chen
authors.affiliation: School of Medicine, Tzu Chi University, Hualien, Taiwan. abanggeelily@gmail.com.|Division of Cardiology, Buddhist Tzu Chi General Hospital, No. 707, Section 3, Chung-Yang Road, Hualien, 97002, Taiwan. abanggeelily@gmail.com.
authors.forename: Ji-Hung
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D052243:Resistin / Q000097:blood*; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D052243:Resistin
keywords: Ankle-brachial index; Hypertension; Peripheral arterial disease; Resistin