title: Modular regulation of Rho family GTPases in development.
abstract: Rho family GTPase signaling regulates the actin cytoskeleton and is critical for behaviors that range from the cell to tissue-scale. A theme in Rho GTPase biology is that there are many more regulators, such as guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), than GTPases themselves. Here, we review different, modular cases where GEFs and GAPs function together to elicit precise spatial and temporal control of signaling. We focus on examples from metazoan development, where precise regulation of Rho GTPases is critical for proper tissue form and function.
authors.affiliation: a Department of Biology , Massachusetts Institute of Technology , Cambridge , MA , USA.
authors.forename: Marlis
authors.initials: M
authors.lastname: Denk-Lobnig
authors.affiliation: a Department of Biology , Massachusetts Institute of Technology , Cambridge , MA , USA.
authors.forename: Adam C
authors.initials: AC
authors.lastname: Martin
mesh_terms: D000818:Animals; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction
chemical_list: D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors
keywords: Bcr; C-GAP; Cdc42; Ect-2; RGA-3; RGA-4; Rac; RhoA; RhoGEF2; Spv-1; morphogenesis