Exploration of Nitrate Reductase Metabolic Pathway inCorynebacterium pseudotuberculosis.
Based on the ability of nitrate reductase synthesis,Corynebacterium pseudotuberculosisis classified into two biovars: Ovis and Equi. Due to the presence of nitrate reductase, the Equi biovar can survive in absence of oxygen. On the other hand, Ovis biovar that does not have nitrate reductase is able to adapt to various ecological niches and can grow on certain carbon sources. Apart from these two biovars, some other strains are also able to carry out the reduction of nitrate. The enzymes that are involved in electron transport chain are also identified by in silico methods. Findings about pathogen metabolism can contribute to the identification of relationship between nitrate reductase and theC. pseudotuberculosispathogenicity, virulence factors, and discovery of drug targets.
Institute of Biologic Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
Sintia
0000-0003-0270-9059
S
Almeida
Institute of Biologic Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
Cassiana
0000-0003-3764-4531
C
Sousa
Center for Nuclear Energy in Agriculture, University of Sao Paulo, 13400-970 Piracicaba, SP, Brazil.
Vinícius
V
Abreu
Institute of Biologic Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
Carlos
C
Diniz
Escola de Veterinária, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Departamento de Medicina Veterinária, Universidade Federal de Lavras, Lavras, MG, Brazil.
Elaine M S
EM
Dorneles
Escola de Veterinária, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Andrey P
0000-0002-9325-5728
AP
Lage
Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India.
Debmalya
D
Barh
Institute of Biologic Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
Vasco
0000-0002-4775-2280
V
Azevedo