Higher Prevalence of Frailty Among a Sample of HIV-Infected Middle-aged and Older Chinese Adults Is Associated With Neurocognitive Impairment and Depressive Symptoms.
We investigated the prevalence and correlates of prefrailty/frailty, determined on the basis of the Fried criteria, in Chinese patients with and those without human immunodeficiency virus (HIV) infection. HIV-infected patients were more likely to be frail or prefrail than controls, and this association remained significant after adjustment for potential confounders (odds ratio, 3.79). After additional adjustment for neurocognitive impairment and depressive and insomnia symptoms, this association remained significant but attenuated (odds ratio, 2.16). In the HIV-infected group, these 3 variables were independently associated with prefrailty/frailty. These findings suggest that neurocognitive impairment and depressive and/or insomnia symptoms may account for a higher prevalence of prefrailty/frailty in HIV-infected patients but require further longitudinal investigation.
Department of Epidemiology, School of Public Health,  Fudan University, Shanghai, China.|Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai.
Yingying
Y
Ding
Taizhou City Center for Disease Control and Prevention, Taizhou City, China.
Haijiang
H
Lin
Department of Epidemiology, School of Public Health,  Fudan University, Shanghai, China.|Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai.
Xing
X
Liu
Department of Epidemiology, School of Public Health,  Fudan University, Shanghai, China.|Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, USA.
Frank Y
FY
Wong
Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
Yan V
YV
Sun
Hubert Department of Global Health, Rollins School of Public Health, Emory University , Atlanta, Georgia, USA.|Department of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia, USA.
Vincent C
VC
Marconi
Department of Epidemiology, School of Public Health,  Fudan University, Shanghai, China.|Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai.
Na
N
He
D000328:Adult; D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D002681:China; D003430:Cross-Sectional Studies; D003863:Depression / Q000150:complications / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000150:complications / Q000453:epidemiology*; D015995:Prevalence; D012959:Socioeconomic Factors
HIV infection; depressive symptoms; frailty; insomnia symptoms.; neurocognitive impairment