Epithelial Homeostasis: A Piezo of the Puzzle.
A recent study shows that, upon stretching or wounding, epithelia display a fast proliferative response that allows for re-establishment of optimal cell density or sealing of the wound. This increased proliferation is induced by the stretch-activated channel Piezo1 and involves calcium-triggered ERK signalling.
The Wellcome Trust/Cancer Research UK Gurdon Institute and Zoology Department, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; School of Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK. Electronic address: ep16996@bristol.ac.uk.
Eugenia
E
Piddini
D020013:Calcium Signaling; D002455:Cell Division; D004847:Epithelial Cells / Q000166:cytology*; D006706:Homeostasis; D007473:Ion Channels / Q000235:genetics*
D007473:Ion Channels