Pertussis Antibody Transfer to Preterm Neonates After Second- Versus Third-Trimester Maternal Immunization.
Preterm infants are most vulnerable to pertussis. Whether they might benefit from maternal immunization is unknown. Extending our previous results in term neonates, this observational study demonstrates that second- rather than third-trimester maternal vaccination results in higher birth anti-pertussis toxin titers in preterm neonates.
Center for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, University of Geneva, Switzerland.|Department of Neonatology and Pediatric Intensive Care, Children's Hospital of Geneva, Switzerland.
Christiane S
CS
Eberhardt
Department of Pediatrics, Children's Hospital of Geneva, Switzerland.
Geraldine
G
Blanchard-Rohner
Center for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, University of Geneva, Switzerland.
Barbara
B
Lemaître
Clinical Research Center, , University of Geneva, Switzerland.
Christophe
C
Combescure
Department of Gynecology and Obstetrics, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Switzerland.
Véronique
V
Othenin-Girard
Department of Gynecology and Obstetrics, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Switzerland.
Antonina
A
Chilin
BioNet-Asia Co, Ltd, Bangkok, Thailand.
Jean
J
Petre
Department of Gynecology and Obstetrics, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Switzerland.
Begoña
B
Martinez de Tejada
Center for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, University of Geneva, Switzerland.|Department of Pediatrics, Children's Hospital of Geneva, Switzerland.
Claire-Anne
CA
Siegrist
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007115:Immunization Schedule; D007231:Infant, Newborn; D007234:Infant, Premature; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D014917:Whooping Cough / Q000517:prevention & control*; D055815:Young Adult
D000907:Antibodies, Bacterial; D010567:Pertussis Vaccine
maternal antibodies; maternal immunization; neonates; pertussis; preterm