Asthma management: A new phenotype-based approach using presence of eosinophilia and allergy.
Asthma is a heterogeneous disease. The Czech Pneumology and Allergology Societies commissioned 10 experts to review the literature and create joint national guidelines for managing asthma, reflecting this heterogeneity. The aim was to develop an easy-to-use diagnostic strategy as a rational approach to the widening opportunities for the use of phenotype-targeted therapy. The guidelines were presented on websites for public comments by members of both the societies. The reviewers' comments contributed to creating the final version of the guidelines. The key hallmark of the diagnostic approach is the pragmatic concept, which assesses the presence of allergy and eosinophilia in each asthmatic patient. The guidelines define three clinically relevant asthma phenotypes: eosinophilic allergic asthma, eosinophilic nonallergic asthma and noneosinophilic nonallergic asthma. The resulting multifunctional classification describing the severity, level of control and phenotype is the starting point for a comprehensive treatment strategy. The level of control is constantly confronted with the intensity of the common stepwise pharmacotherapy, and the concurrently included phenotyping is essential for phenotype-specific therapy. The concept of the asthma approach with assessing the presence of eosinophilia and allergy provides a way for more precise diagnosis, which is a prerequisite for using widening options of personalized therapy.
Czech Pneumology and Phthiseology Society, Prague, Czech Republic.
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http://orcid.org/0000-0001-6612-3888
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Terl
Czech Pneumology and Phthiseology Society, Prague, Czech Republic.
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Sedlák
Czech Society of Allergology and Clinical Immunology, Prague, Czech Republic.
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Cap
Czech Pneumology and Phthiseology Society, Prague, Czech Republic.
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Dvořáková
Czech Pneumology and Phthiseology Society, Prague, Czech Republic.
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Kašák
Czech Society of Allergology and Clinical Immunology, Prague, Czech Republic.
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Kočí
Czech Society of Allergology and Clinical Immunology, Prague, Czech Republic.
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Novotna
Czech Society of Allergology and Clinical Immunology, Prague, Czech Republic.
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Seberova
Czech Society of Allergology and Clinical Immunology, Prague, Czech Republic.
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Panzner
Czech Pneumology and Phthiseology Society, Prague, Czech Republic.
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Zindr
D001249:Asthma / Q000145:classification / Q000175:diagnosis* / Q000628:therapy; D004802:Eosinophilia / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000473:pathology; D010641:Phenotype; D057285:Precision Medicine; D012720:Severity of Illness Index
allergy; asthma heterogeneity; eosinophilia; phenotype-specific therapy