Circulating Estrogen Levels and Self-Reported Health and Mobility Limitation in Community-Dwelling Men of the Framingham Heart Study.
BACKGROUND
Self-rated health is a commonly used global indicator of health status. Few studies have examined the association of self-rated health and mobility with estrone and estradiol in men. Accordingly, we determined the cross-sectional, incident, and mediating relations between circulating estrone and estradiol levels with self-rated health, mobility limitation, and physical performance in community-dwelling men.


METHODS
The cross-sectional sample included 1,148 men, who attended Framingham Offspring Study Examinations 7 and 8. Estrone and estradiol levels were measured using liquid chromatography tandem mass spectrometry at Examination 7. Self-reported mobility limitation and self-rated health were assessed at Examinations 7 and 8. Additionally, short physical performance battery, usual walking speed, and grip strength were assessed at Examination 7.


RESULTS
In incident analysis, estradiol levels at Examination 7 were associated with increased odds of fair or poor self-rated health at Examination 8, after adjusting for age, body mass index, comorbidities, and testosterone levels; in an individual with 50% greater estradiol than other, the odds of reporting "fair or poor" self-rated health increased by 1.78 (95% confidence interval: 1.25-2.55; p = .001). Neither estrone nor estradiol levels were associated with any physical performance measure at baseline.


CONCLUSIONS
Higher circulating levels of estradiol are associated with increased risk of incident fair/poor self-rated health in community-dwelling men. The mechanisms by which circulating levels of estradiol are related to self-rated health in men need further investigation.
Center for Healthcare Organization and Implementation Research, Bedford VA Medical Center, Massachusetts.|Boston University School of Public Health, Massachusetts.
Guneet Kaur
GK
Jasuja
Hebrew SeniorLife, Institute for Aging Research, Boston, Massachusetts.|Harvard Medical School, Boston, Massachusetts.
Thomas G
TG
Travison
The National Heart, Lung and Blood Institute's Framingham Heart Study, Massachusetts.|Section of General Internal Medicine, Boston University School of Medicine, Massachusetts.
Joanne M
JM
Murabito
Brigham and Women's Hospital, Research Program in Men's Health, Aging and Metabolism, Harvard Medical School, Boston, Massachusetts.
Maithili N
MN
Davda
Section of General Internal Medicine, Boston University School of Medicine, Massachusetts.
Adam J
AJ
Rose
Brigham and Women's Hospital, Research Program in Men's Health, Aging and Metabolism, Harvard Medical School, Boston, Massachusetts.
Shehzad
S
Basaria
Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Massachusetts.
Andrea
A
Coviello
Boston University School of Public Health, Massachusetts.|The National Heart, Lung and Blood Institute's Framingham Heart Study, Massachusetts.|Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Massachusetts.
Ramachandran S
RS
Vasan
The National Heart, Lung and Blood Institute's Framingham Heart Study, Massachusetts.|Department of Mathematics, Boston University, Massachusetts.
Ralph
R
D'Agostino
Brigham and Women's Hospital, Research Program in Men's Health, Aging and Metabolism, Harvard Medical School, Boston, Massachusetts.
Shalender
S
Bhasin
D000368:Aged; D000375:Aging / Q000502:physiology*; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood*; D004970:Estrone / Q000097:blood*; D015577:Geriatric Assessment / Q000379:methods / Q000706:statistics & numerical data; D018737:Hand Strength / Q000502:physiology; D054624:Health Status Disparities; D006801:Humans; D057187:Independent Living / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D012647:Self-Assessment; D013223:Statistics as Topic; D014481:United States / Q000453:epidemiology; D000072797:Walking Speed / Q000502:physiology
D004970:Estrone; D004958:Estradiol
Estradiol; Estrone; Physical function; Self-rated health