Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice.
Cigarette smoking (CS) is a major cause of considerable morbidity and mortality by inducing lung cancer and COPD. COPD, a smoking-related disorder, is closely related to the alteration of immune system and inflammatory processes that are specifically mediated by T cells. Soluble common gamma chain (sγc) has recently been identified as a critical regulator of the development and differentiation of T cells. We examined the effects of sγc in a cigarette smoke extract (CSE) mouse model. The sγc level in CSE mice serum is significantly downregulated, and the cellularity of lymph node (LN) is systemically reduced in the CSE group. Overexpression of sγc enhances the cellularity and IFNγ production of CD8 T cells in LN and also enhances Th1 and Th17 differentiation of CD4 T cells in the respiratory tract. Mechanistically, the downregulation of sγc expression mediated by CSE is required to prevent excessive inflammatory T cell responses. Therefore, our data suggest that sγc may be one of the target molecules for the control of immunopathogenic progresses in COPD.
Department of Anatomy and Cell Biology, Pusan National University School of Medicine.
Byunghyuk
B
Lee
Department of Anatomy and Cell Biology, Pusan National University School of Medicine.
Eunhee
E
Ko
Division of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan.
Jiyeon
J
Lee
Department of Anatomy and Cell Biology, Pusan National University School of Medicine.
Yuna
Y
Jo
Department of Anatomy and Cell Biology, Pusan National University School of Medicine.
Hyunju
H
Hwang
Department of Anatomy and Cell Biology, Pusan National University School of Medicine; Department of Orthopedic Surgery, Medical Research Institute, Pusan National University School of Medicine, Busan, South Korea.
Tae Sik
TS
Goh
Division of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan.
Myungsoo
M
Joo
Department of Anatomy and Cell Biology, Pusan National University School of Medicine.
Changwan
C
Hong
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D018450:Disease Progression; D007371:Interferon-gamma / Q000276:immunology / Q000378:metabolism; D053631:Interleukin Receptor Common gamma Subunit / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D008168:Lung / Q000276:immunology* / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000378:metabolism; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D011014:Pneumonia / Q000209:etiology / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D012906:Smoke / Q000009:adverse effects; D012907:Smoking / Q000009:adverse effects; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism; D013997:Time Factors
C000611649:IFNG protein, mouse; C507942:Il2rg protein, mouse; D053631:Interleukin Receptor Common gamma Subunit; D012906:Smoke; D007371:Interferon-gamma
COPD; T cell; cytokine; soluble common gamma chain