Neuronatin Is Associated with an Anti-Inflammatory Role in the White Adipose Tissue.
Neuronatin (NNAT) is known to regulate ion channels during brain development and plays a role in maintaining the structure of the nervous system. A previous in silico analysis showed thatNnatwas overexpressed in the adipose tissue of an obese rodent model relative to the wild type. Therefore, the aim of the present study was to investigate the function ofNnatin the adipose tissue. Because obesity is known to systemically induce low-grade inflammation, theNnatexpression level was examined in the adipose tissue obtained from C57BL/6 mice administered lipopolysaccharide (LPS). Unexpectedly, theNnatexpression level decreased in the white adipose tissue after LPS administration. To determine the role of NNAT in inflammation, 3T3-L1 cells overexpressingNnatwere treated with LPS. The level of the p65 subunit of nuclear factor-kappa B (NF-κB) and the activity of NF-κB luciferase decreased following LPS treatment. These results indicate that NNAT plays an anti-inflammatory role in the adipose tissue.
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Hye In
HI
Ka
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Sora
S
Han
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Ae Lee
AL
Jeong
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Sunyi
S
Lee
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Hyo Jeong
HJ
Yong
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Ariundavaa
A
Boldbaatar
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Hyun Jeong
HJ
Joo
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Su Jung
SJ
Soh
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Ji Young
JY
Park
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Jong-Seok
JS
Lim
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Myung Sok
MS
Lee
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Young
Y
Yang
D041721:3T3-L1 Cells; D052436:Adipose Tissue, White / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D000818:Animals; D003198:Computer Simulation; D015870:Gene Expression; D007249:Inflammation; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000187:drug effects / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000502:physiology*; D009765:Obesity / Q000276:immunology; D015398:Signal Transduction
D008070:Lipopolysaccharides; D008565:Membrane Proteins; D016328:NF-kappa B; D009419:Nerve Tissue Proteins; C490239:Nnat protein, mouse
Adipocyte; NF-κB; anti-inflammation; inflammation; neuronatin; obesity