[Colorectal cancer the importance of primary tumor location].
Retrospective evaluations of the relevance of primary colorectal cancer (CRC) location consistently indicate that right-sided tumors, arising in the cecum, ascending colon, hepatic bend, transverse colon and splenic flexure, are clinically, biologically and genetically different from left-sided tumors - those located in the descending colon, sigmoid colon or rectum. Location in the right-sided colon represents a negative prognostic indicator, particularly for stage III and IV carcinomas. Irrespective of treatment, the rightward location is associated with a significantly increased risk of death when compared to the left side.Key words: colorectal cancer - location - therapy - prognosis.
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M
Ryska
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J
Bauer
D044684:Colon, Transverse / Q000601:surgery; D015179:Colorectal Neoplasms / Q000134:cerebrospinal fluid / Q000601:surgery; D006801:Humans; D011379:Prognosis; D012189:Retrospective Studies