APOL1: a case in point for replacing race with genetics.
Ethnicity-specific differences in apolipoprotein L1 (APOL1) polymorphisms are associated with racial disparities in kidney transplantation outcomes. APOL1 genotyping may better help define graft outcome risk pre-transplantation; however, more research is needed.
Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: girish.nadkarni@mssm.edu.
Girish N
GN
Nadkarni
Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Christina M
CM
Wyatt
Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Barbara
B
Murphy
Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Michael J
MJ
Ross
D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000235:genetics*; D046148:Donor Selection / Q000379:methods*; D005820:Genetic Testing; D005838:Genotype; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects; D008075:Lipoproteins, HDL / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D011183:Postoperative Complications / Q000208:ethnology / Q000235:genetics; D044469:Racial Groups; D018570:Risk Assessment; D012307:Risk Factors; D014019:Tissue Donors; D016896:Treatment Outcome
C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D008075:Lipoproteins, HDL