[Advances in the research of basic study and clinical application of adipose-derived mesenchymal stem cells].
Since the discovery of adipose-derived mesenchymal stem cell (ADSC) in more than ten years, a great progress has been made from its basic research to clinical application. Compared with bone marrow mesenchymal stem cells, ADSCs are more abundant in reserve, easier to obtain with fewer injuries and less complications. These cells have multiple differentiation potential and can differentiate into adipocytes, chondrocytes and osteoblasts with the influence of different inducing factors. Early studies of ADSCs mainly focused on the ability of multi-directional differentiation, espe-cially on the regeneration of bone defects and cartilage tissue. At present, the researches mainly focus on immunoregulation and paracrine function of ADSCs. Although ADSCs have made a great progress in clinical application, the cell preparation, use pattern, and mechanisms in clinical treatment are not clear. This paper elaborates on these issues.
Department of Burns, the Third Affiliated Hospital of Inner Mongolia Medical University, Baotou 014010, China.
S J
SJ
Cao
L F
LF
Wang
T
T
Ba
Z D
ZD
Rong
G L
GL
Hu
B
B
Zhou
Q
Q
Li
D017667:Adipocytes; D000273:Adipose Tissue / Q000166:cytology*; D002454:Cell Differentiation; D019902:Chondrocytes / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism / Q000502:physiology*; D013234:Stem Cells
Adipose derived stem cells; Basic research; Clinical application; Stem cells