Anti-Allergic Compounds from the Deep-Sea-Derived Actinomycete Nesterenkonia flava MCCC 1K00610.
A novel cyclic ether, nesterenkoniane (1), was isolated from the deep-sea-derived actinomyceteNesterenkonia flavaMCCC 1K00610, together with 12 known compounds, including two macrolides (2,3), two diketopiperazines (4,5), two nucleosides (6,7), two indoles (8,9), three phenolics (10-12), and one butanol derivate (13). Their structures were established mainly on detailed analysis of the NMR and MS spectroscopic data. All 13 compounds were tested for anti-allergic activities using immunoglobulin E (IgE) mediated rat mast RBL-2H3 cell model. Under the concentration of 20 μg/mL,1exhibited moderate anti-allergic activity with inhibition rate of 9.86%, compared to that of 37.41% of the positive control, loratadine. While cyclo(d)-Pro-(d)-Leu (4) and indol-3-carbaldehyde (8) showed the most potent effects with the IC50values of 69.95 and 57.12 μg/mL, respectively, which was comparable to that of loratadine (IC50= 35.01 μg/mL). To the best of our knowledge, it is the first report on secondary metabolites from the genus ofNesterenkonia.
State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, Xiamen 361005, China. xiechunlanxx@163.com.|Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. xiechunlanxx@163.com.
Chun-Lan
CL
Xie
College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 36102, China. liuqingmei1229@163.com.
Qingmei
Q
Liu
State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, Xiamen 361005, China. xiajinmei@tio.org.cn.
Jin-Mei
JM
Xia
College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 36102, China. yuanyuan201736@163.com.
Yuanyuan
Y
Gao
Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. yangquan7208@vip.163.com.
Quan
Q
Yang
State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, Xiamen 361005, China. shaozongze@tio.org.cn.
Zong-Ze
ZZ
Shao
College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 36102, China. gmliu@jmu.edu.cn.
Guangming
G
Liu
State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, Xiamen 361005, China. yangxianwen@tio.org.cn.
Xian-Wen
XW
Yang
D039903:Actinobacteria / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000494:pharmacology*; D000440:Butanols / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D054659:Diketopiperazines / Q000737:chemistry / Q000494:pharmacology; D007073:Immunoglobulin E / Q000378:metabolism; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D017336:Loratadine / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000494:pharmacology; D008407:Mast Cells / Q000187:drug effects; D008835:Micrococcaceae / Q000737:chemistry* / Q000378:metabolism*; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
D018926:Anti-Allergic Agents; D000440:Butanols; D054659:Diketopiperazines; D007211:Indoles; D018942:Macrolides; D009705:Nucleosides; D007073:Immunoglobulin E; D017336:Loratadine
Nesterenkonia; actinomycetes; deep-sea; food allergy