[Effectiveness of prevention of mother to child HIV transmission in Henan province, 2002-2013].
Objective:To evaluate the effectiveness of the intervention on preventing mother to child transmission of HIV and identify the influencing factors.Methods:The data regarding the pregnant women and their infants were collected, including demographic characteristics, pregnancy and delivery, access to antiviral therapy, HIV infection status at age 18 months and survival of infants between 2002 and 2013 through follow-up, Multivariate logistic regression model were used to identify the influencing factors.Results:By the end of 2013, a total of 8 621 554 pregnant women received HIV test, among them 2 264 were infected with HIV. The positive rate of HIV is 0.03%. The HIV positive rate decreased year by year (χ(2) =4.871,P=0.027). A total of 1 530 infants were born from 2002 to 2013, among them 1 384 survived and 92 died at age of 18 months, and 54 were lost for follow up. Sixty infants were tested to be HIV-positive, 1 324 infants were tested to be HIV-negative. The mother to child transmission rate was 4.34%, the corrective mother to child transmission rate was 6.33%. Receiving HIV prevention service in early pregnancy (OR=0.26, 95% CI: 0.09-0.77), standardized antiviral therapy (OR=0.42, 95% CI: 0.21-0.82), artificial feeding (OR=0.06, 95% CI: 0.02-0.21) might be the main protective factors, episiotomy on delivery (OR=3.91, 95% CI: 1.74-8.80) might be the risk factors.Conclusion:The HIV tested positive rate remained to be low and decreased year by year in pregnant women in Henan, but the mother to child HIV transmission rate was high. It is necessary to improve the prevention of mother to child HIV transmission.
Institute of STD/AIDS Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
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Wang
Institute of STD/AIDS Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
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Sun
Institute of STD/AIDS Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
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Fan
Institute of STD/AIDS Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
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Ma
Henan Provincial Academy of Medical Science, Zhengzhou 450016, China.
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Ma
Institute of STD/AIDS Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
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Si
Institute of STD/AIDS Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
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Li
Institute of STD/AIDS Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
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Wang
D000163:Acquired Immunodeficiency Syndrome; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control / Q000635:transmission; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D016015:Logistic Models; D059012:Lost to Follow-Up; D009035:Mothers; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011256:Pregnancy Outcome; D015397:Program Evaluation
D019380:Anti-HIV Agents
AIDS; Infant; Influencing factor; Mother to child transmission