A compendium of proteins that interact with HIF-1α.
Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is composed of an O2-regulated HIF-1α subunit and a constitutively expressed HIF-1β subunit. This review provides a compendium of proteins that interact with the HIF-1α subunit, many of which regulate HIF-1 activity in either an O2-dependent or O2-independent manner.
Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205 USA. Electronic address: gsemenza@jhmi.edu.
Gregg L
GL
Semenza
D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000378:metabolism*; D015687:Cell Hypoxia / Q000502:physiology; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
C497396:ARNT protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D014157:Transcription Factors; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator; D010100:Oxygen
Oxygen biology; Transcriptional regulation