Bioactive constituents from transformed root cultures of Nepeta teydea.
A phytochemical study of an extract from transformed root cultures of Nepeta teydea, induced by Agrobacterium rhizogenes, led to the isolation of the following new compounds: the sesquiterpene (-)-cinalbicol, the diterpene teydeadione (6,11,14-trihydroxy-12-methoxy-abieta-5,8,11,13,15-penten-7-one), a degraded C23-triterpene (teydealdehyde) and three fatty acid esters of lanosta-7,24-dien-3β-ol. The propyl ester of rosmarinic acid was also isolated for the first time from a natural source. In addition, two dehydroabietane diterpenes, eight triterpenes and eighteen known phenolic compounds were obtained. The antifeedant, cytotoxic and phytotoxic activities of the isolated compounds have also been investigated.
Instituto de Productos Naturales y Agrobiología, CSIC, Avda. Astrofísico F. Sánchez 3, 38206, La Laguna, Tenerife, Canary Islands, Spain. Electronic address: bmfraga@ipna.csic.es.
Braulio M
BM
Fraga
Instituto de Ciencias Agrarias, CSIC, Serrano 113, 28006, Madrid, Spain.
Azucena
A
González-Coloma
Instituto de Ciencias Agrarias, CSIC, Serrano 113, 28006, Madrid, Spain.
Sergio
S
Alegre-Gómez
Instituto Universitario de Bioorgánica "Antonio González", Universidad de La Laguna, Tenerife, Spain.
Matías
M
López-Rodríguez
Instituto de Productos Naturales y Agrobiología, CSIC, Avda. Astrofísico F. Sánchez 3, 38206, La Laguna, Tenerife, Canary Islands, Spain.
Leonardo J
LJ
Amador
Instituto de Productos Naturales y Agrobiología, CSIC, Avda. Astrofísico F. Sánchez 3, 38206, La Laguna, Tenerife, Canary Islands, Spain.
Carmen E
CE
Díaz
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D046508:Culture Techniques; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification; D027521:Nepeta / Q000737:chemistry* / Q000254:growth & development; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D018517:Plant Roots / Q000737:chemistry* / Q000254:growth & development; D018411:Spodoptera
D003603:Cytotoxins; D007306:Insecticides; D010936:Plant Extracts
(-)-Cinalbicol; Biological activity; Diterpenes; Lamiaceae; Nepeta teydea; Phenolic compounds; Sesquiterpenes; Teydeadione; Teydealdehyde; Transformed root cultures; Triterpenes