Azomethine-isocyanide [3+2] cycloaddition to imidazoles promoted by silver and DBU.
A new silver-promoted [3+2] cycloaddition of azomethine ylides with isocyanides has been described. The methodology provides an efficient and modular approach to 1,2,4-trisubstituted imidazoles of vital bioactive molecules and atypical antipsychotics analogues.
Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, 130024 Changchun, China. bixh507@nenu.edu.cn.
Xiaoshan
X
Huang
Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, 130024 Changchun, China. bixh507@nenu.edu.cn.
Xuefeng
X
Cong
Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, 130024 Changchun, China. bixh507@nenu.edu.cn.
Pengbing
P
Mi
Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, 130024 Changchun, China. bixh507@nenu.edu.cn and State Key Laboratory of Elemento-Organic Chemistry, Nankai University, 300071 Tianjin, China.
Xihe
http://orcid.org/0000-0002-6694-6742
X
Bi