Bullous pemphigoid of infancy - report and review of infantile and pediatric bullous pemphigoid.
A 4-month-old infant was observed with an acute itchy bullous dermatosis, predominantly involving the extremities, which revealed a dermal infiltrate rich in eosinophils, C3 deposits at the dermalepidermal junction, and circulating antibodies to BP180 antigen, confirming the diagnosis of bullous pemphigoid. He was initially treated with deflazacort 1 mg/kg/day, further increased to 2 mg/ kg/day, followed by reduction over seven weeks with complete clinical resolution within this period. We discuss epidemiology, etiology, relationship with vaccination, clinical features, and treatment of thisrelatively rare bullous dermatosis in the pediatric age.
Department of Dermatology, Coimbra Hospital and University Centre, Coimbra, Portugal. barbara.roqueferreira@gmail.com.
Bárbara R
BR
Ferreira
Ana S
AS
Vaz
Leonor
L
Ramos
José P
JP
Reis
Margarida
M
Gonçalo
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D003176:Complement C3 / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D019085:Fluorescent Antibody Technique, Direct; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007223:Infant; D008297:Male; D024041:Non-Fibrillar Collagens / Q000276:immunology; D010391:Pemphigoid, Bullous / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D011282:Pregnenediones / Q000627:therapeutic use; D000097805:Collagen Type XVII
D000893:Anti-Inflammatory Agents; D001323:Autoantibodies; D001324:Autoantigens; D003176:Complement C3; D024041:Non-Fibrillar Collagens; D011282:Pregnenediones; D000097805:Collagen Type XVII; C021988:deflazacort