Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study.
Cardiopulmonary fitness is decreased in type 1 diabetes for reasons that are incompletely understood. In this study, leptin was associated with exercise capacity independent of insulin sensitivity (IS) and body mass index (BMI), suggesting that leptin may relate to cardiopulmonary fitness by mechanisms beyond IS and/or obesity.
Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO. Electronic address: Petter.Bjornstad@childrenscolorado.org.
Petter
P
Bjornstad
Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States; Center for Women's Health Research, Divisions of General Internal Medicine and Cardiology, University of Colorado School of Medicine, Aurora, CO, United States.
Melanie
M
Cree-Green
Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.
Amy
A
Baumgartner
Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.
Gregory
G
Coe
Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.
Yesenia Garcia
YG
Reyes
Division of Pediatric Cardiology, University of Colorado School of Medicine, Aurora, CO, United States.
Michal
M
Schafer
Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.
Laura
L
Pyle
Center for Women's Health Research, Divisions of General Internal Medicine and Cardiology, University of Colorado School of Medicine, Aurora, CO, United States; Divisions of General Internal Medicine and Cardiology, University of Colorado School of Medicine, Aurora, CO, United States.
Judith G
JG
Regensteiner
Center for Women's Health Research, Divisions of General Internal Medicine and Cardiology, University of Colorado School of Medicine, Aurora, CO, United States; Division of Endocrinology, Veterans Administration Hospital, University of Colorado School of Medicine, Aurora, CO, United States.
Jane E B
JEB
Reusch
Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States; Center for Women's Health Research, Divisions of General Internal Medicine and Cardiology, University of Colorado School of Medicine, Aurora, CO, United States.
Kristen J
KJ
Nadeau
D050154:Adiposity; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D000072599:Cardiorespiratory Fitness; D002648:Child; D003120:Colorado; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D050177:Overweight / Q000150:complications*; D010101:Oxygen Consumption; D063766:Pediatric Obesity / Q000150:complications*; D012727:Sex Characteristics; D055815:Young Adult
D015415:Biomarkers; D020738:Leptin
Adiposity; Cardiopulmonary fitness; Insulin sensitivity; Leptin; Type 1 diabetes