Phyllodes Tumor of the Breast: Analysis of 48 Patients.
OBJECTIVE
Phyllodes tumor (PT) is a rare biphasic breast neoplasm that accounts for less than 1% of all breast tumors. The aim of this study was to evaluate the clinicopathologic features, diagnostic difficulties, and therapeutic outcomes of patients with PT.


METHODS
A total of 48 female patients who underwent surgery for PT were included in the study. Patient characteristics, clinicopathologic features of tumors, diagnostic findings, surgical outcomes, adjuvant therapies, and follow-up findings were retrospectively evaluated.


RESULTS
The mean age of patients was 35 years. Painless breast mass was the most common (85.4%) presenting symptom. Total excision with at least 1 cm macroscopic clear margins was the most frequently performed (87.5%) surgery. Most patients (n=34, 70.8%) had benign PT; however, borderline and malignant tumors were found in 9 (18.8%) and 5 (10.4%) patients, respectively. During the mean follow-up period of approximately 30 months, local and distant recurrence was detected in three (6.3%) patients and one (2.1%) patient, respectively. Patients with malignant PT had larger tumors than those with benign and borderline PTs (p=0.010). No significant difference in other clinical, diagnostic, and pathologic characteristics was found between the groups.


CONCLUSIONS
PT can be easily confused with other breast masses such as fibroadenoma due to the non-specific clinical and radiologic findings. Surgical excision with at least 1 cm clear margins is of great importance to reduce the risk of local recurrence. However, recurrence can develop even after appropriate surgery, thus patients should be closely followed up after surgery.
Clinic of General Surgery, Numune Training and Research Hospital, Ankara, Turkey.
Murat Özgür
MÖ
Kılıç
Clinic of General Surgery, Numune Training and Research Hospital, Ankara, Turkey.
Serdar Gökay
SG
Terzioğlu
Clinic of General Surgery, Numune Training and Research Hospital, Ankara, Turkey.
Betül
B
Bozkurt
Clinic of General Surgery, Numune Training and Research Hospital, Ankara, Turkey.
Gül
G
Dağlar
Breast; diagnosis; phyllodes tumor; treatment