Three variants of the leukotoxin gene in human isolates of Fusobacterium necrophorum subspecies funduliforme.
Leukotoxin is a well-known virulence factor of animal isolates of Fusobacterium necrophorum subspecies necrophorum, and is also expressed by animal isolates of subspecies funduliforme, whereas its presence in isolates from humans has not been fully established. In this study we found that the leukotoxin gene was present in all tested F. necrophorum isolates from humans. Three sequence variants were found, two of which have not been described previously. The sequence types correlated to source of infection. Further studies are needed to examine the role of the leukotoxin in human infections.
Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden. Electronic address: karin.holm@med.lu.se.
Karin
K
Holm
Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden.
Mattias
M
Collin
Department of Clinical Microbiology and Department of Medicine, Viborg Regional Hospital, Viborg, Denmark.
Lena
L
Hagelskjær-Kristensen
Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark.
Anders
A
Jensen
Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden.
Magnus
M
Rasmussen
D005098:Exotoxins / Q000235:genetics*; D005674:Fusobacterium Infections / Q000382:microbiology*; D005675:Fusobacterium necrophorum / Q000235:genetics* / Q000302:isolation & purification; D005838:Genotype; D006801:Humans; D007166:Immunosuppressive Agents; D017422:Sequence Analysis, DNA; D037521:Virulence Factors / Q000235:genetics*
D005098:Exotoxins; D007166:Immunosuppressive Agents; D037521:Virulence Factors; C018579:leukotoxin
Fusobacterium necrophorum; Lemierre; Leukocidin; Leukotoxin; Pharyngotonsillitis; Sequencing