Toll-like receptor-associated keratitis and strategies for its management.
Keratitis is an inflammatory condition, characterized by involvement of corneal tissues. Most recurrent challenge of keratitis is infection. Bacteria, virus, fungus and parasitic organism have potential to cause infection. TLR are an important class of protein which has a major role in innate immune response to combat with pathogens. In last past years, extensive research efforts have provided considerable abundance information regarding the role of TLR in various types of keratitis. This paper focuses to review the recent literature illustrating amoebic, bacterial, fungal and viral keratitis associated with Toll-like receptor molecules and summarize existing thoughts on pathogenesis and treatment besides future probabilities for prevention against TLR-associated keratitis.
Department of Biotechnology, Lovely Professional University, Phagwara, 144411, Punjab, India.
Amandeep
A
Kaur
Department of Chemistry, Lovely Professional University, Phagwara, 144411, Punjab, India.
Vijay
V
Kumar
Department of Biotechnology, Lovely Professional University, Phagwara, 144411, Punjab, India.
Simranjeet
S
Singh
Department of Chemistry, Lovely Professional University, Phagwara, 144411, Punjab, India.
Joginder
J
Singh
Department of Chemistry, Lovely Professional University, Phagwara, 144411, Punjab, India. nivij.res@gmail.com.
Niraj
N
Upadhyay
Department of Zoology, Lovely Professional University, Phagwara, 144411, Punjab, India.
Shivika
S
Datta
Department of Biotechnology, Lovely Professional University, Phagwara, 144411, Punjab, India.
Sourav
S
Singla
Department of Chemistry, Lovely Professional University, Phagwara, 144411, Punjab, India.
Virender
V
Kumar
Cytokines; Infection; Keratitis; Toll-like receptor; Treatment