Maternal obesity and inflammatory mediators: A controversial association.
The link between maternal obesity and inflammatory mediators is still unclear. Our aim was to summarize the main findings of recently published studies on this topic. We performed a search in Medline for studies published in the last years on obesity, human pregnancy, and inflammatory mediators. We report the findings of 30 studies. The characteristics and number of participants, study design, gestational age at sample collection, and type of sample varied widely. Approximately two-thirds of them investigated more than one mediator, and 50% included participants in only one trimester of pregnancy. The most frequently investigated mediators were leptin, tumour necrosis factor-alpha (TNF-α), and interleukin (IL)-6. Almost all studies reported an association between maternal obesity, leptin, and C-reactive protein (CRP) serum levels but not with IL-1β and IL-10. The association of IL-6, TNF-α, monocyte chemo-attractant protein-1 (MCP-1), adiponectin, and resistin with maternal obesity is still controversial. To clarify the physiopathological link between maternal obesity and inflammation, more high-quality studies are needed.
Department of Obstetrics, Universidade Federal de São Paulo, São Paulo, Sao Paulo, Brazil.
Karen Priscilla Tezotto
KPT
Pendeloski
Department of Obstetrics, Universidade Federal de São Paulo, São Paulo, Sao Paulo, Brazil.
Erika
E
Ono
Department of Obstetrics, Universidade Federal de São Paulo, São Paulo, Sao Paulo, Brazil.
Maria Regina
MR
Torloni
Department of Obstetrics, Universidade Federal de São Paulo, São Paulo, Sao Paulo, Brazil.
Rosiane
R
Mattar
Department of Obstetrics, Universidade Federal de São Paulo, São Paulo, Sao Paulo, Brazil.
Silvia
0000-0001-5312-7804
S
Daher
D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D018836:Inflammation Mediators / Q000032:analysis*; D009765:Obesity / Q000150:complications*; D011247:Pregnancy; D011248:Pregnancy Complications
D018836:Inflammation Mediators
adipokine; cytokine; inflammatory mediator; maternal obesity; pregnancy