[Epigenetic regulations and cerebral plasticity: towards new therapeutic options in neurodegenerative diseases?]
Although revealed in the 1950's, epigenetics is still a fast-growing field. Its delineations continuously evolve and become clarified. In particular, "neuroepigenetics", a notion that encompasses epigenetic regulations associated with neuronal processes, appears very promising. Indeed, the challenge to be undertaken in this sub-field is double. On the one hand, it should bring molecular comprehension of specific neuronal processes, some of them falling within the long term regulations, such as learning and memory. On the other hand, it could bring therapeutic options for brain diseases, e.g. neurodegenerative diseases such as Alzheimer's or Huntington's diseases.
Karine
K
Merienne
Anne-Laurence
AL
Boutillier
D000818:Animals; D044127:Epigenesis, Genetic / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D058990:Molecular Targeted Therapy / Q000639:trends*; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000628:therapy*; D009473:Neuronal Plasticity / Q000235:genetics*