Disseminated Lichtheimia ramosa Infection After Hematopoietic Stem Cell Transplantation in a Child With Chronic Granulomatous Disease.
Mucormycosis is uncommon in patients with chronic granulomatous disease (CGD). We report a 7-year-old boy with X-linked CGD and absent oxidative burst who developed fatal Lichtheimia ramosa infection with fungal thrombosis of the kidneys, spleen and other organs after hematopoietic stem cell transplantation. Lichtheimia infection is rarely reported in patients with CGD and could be related to iatrogenic immunosuppression.
From the *Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, and †Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Michael
M
Winstead
John
J
Ozolek
Andrew
A
Nowalk
John
J
Williams
Mark
M
Vander Lugt
Philana
P
Lin
D017809:Fatal Outcome; D006105:Granulomatous Disease, Chronic / Q000382:microbiology / Q000601:surgery*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D009090:Mucorales / Q000302:isolation & purification*; D009091:Mucormycosis / Q000209:etiology*; D020246:Venous Thrombosis / Q000382:microbiology