A first insight into the genetic diversity ofMycobacterium Tuberculosisin Veracruz, Mexico.
Tuberculosis (TB) remains one of the most important infectious diseases. Although Mexico is one of the Latin American countries with the largest contribution to these statistics, there are few reports that describe the genotypic characteristics of TB. The aim of this study was to use the MIRU-VNTR-24 loci to analyze the genetic diversity of M. tuberculosis circulating in the state of Veracruz, Mexico.



Here, we analyze by MIRU-VNTR-24 loci 80 clinical isolates from individuals with confirmed TB from Veracruz México, also clinical and epidemiological variables were recovered and analyzed.



Of the individuals included in the analyses 65% were from men with an average age of 42 (± 17) years, 17% and 6% were drug and multi-drug resistant. 88% of the isolates were included in 20 clusters, of which 52% were classified into twelve orphan clusters and the remaining 37% were distributed among eight lineages: LAM (10%), EAI (9%), Haarlem (8%), H37Rv (4%), S (4%) and TUR (2%).



An important diversity of lineages and unknown genotypes was identified; however, more studies are necessary in order to understand the characteristics of the genotypes displayed in the region. There is no doubt regarding the need for a molecular epidemiological surveillance system that can help to evaluate the dynamics of genotypes circulating in the country and support strategies for the prevention and management of populations affected by TB.
Ecology and Health Laboratory, Public Health Institute, University of Veracruz, Xalapa, México.
Raquel
R
Almaraz-Velasco
Ecology and Health Laboratory, Public Health Institute, University of Veracruz, Xalapa; Health Sciences Institute, University of Veracruz, Jalapa, México.
Daniela
D
Munro-Rojas
State Program of Mycobacteriosis, Health Jurisdictions V and VII, Veracruz Health Services, Veracruz, México.
Javier
J
Fuentes-Domínguez
Multidisciplinary Research Network on Tuberculosis; Epidemiology and Molecular Ecology Laboratory, School of Health Sciences, Autonomous University of Baja California, Ensenada, Baja California, México.
Raquel
R
Muñiz-Salazar
State Program of Mycobacteriosis, Health Jurisdictions V and VII, Veracruz Health Services, Veracruz, México.
Maria Angélica
MA
Ibarra-Estela
State Program of Mycobacteriosis, Health Jurisdictions V and VII, Veracruz Health Services, Veracruz, México.
Alma Delia
AD
Guevara-Méndez
State Program of Mycobacteriosis, Health Jurisdictions V and VII, Veracruz Health Services, Veracruz, México.
Rosa Icela
RI
Chaparro-Martinez
Nefrology Services, General Hospital "Dr. Eduardo Liceaga", México.
Monserrat
M
Perez-Navarro
Ecology and Health Laboratory, Public Health Institute, University of Veracruz, Xalapa; Multidisciplinary Research Network on Tuberculosis, Ensenada, Baja California, México.
Roberto
R
Zenteno-Cuevas
D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D003430:Cross-Sectional Studies; D004269:DNA, Bacterial / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D018598:Minisatellite Repeats; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology*
D000995:Antitubercular Agents; D004269:DNA, Bacterial