The clinical epidemiology of young adults starting renal replacement therapy in the UK: presentation, management and survival using 15 years of UK Renal Registry data.
Clinical epidemiology data for young adults on renal replacement therapy (RRT) are lacking. While mostly transplanted, they have an increased risk of graft loss during young adulthood.



We combined the UK Renal Registry paediatric and adult databases to describe patient characteristics, transplantation and survival for young adults. We grouped patients 11-30 years of age starting RRT from 1999 to 2008 by age band and examined their course during 5 years of follow-up.



The cohort (n = 3370) was 58% male, 79% white and 29% had glomerulonephritis. Half (52%) started RRT on haemodialysis (HD). Most (78%) were transplanted (18% pre-emptive, 61% as second modality); 11% were not listed for transplant. Transplant timing varied by age group. The deceased:living donor kidney transplant ratio was 2:1 for 11-<16 year olds and 1:1 otherwise. Median deceased donor transplant waiting times ranged from 6 months if <16 years of age to 17 months if ≥21 years. Overall 8% died, with being on dialysis and not transplant listed versus transplanted {hazard ratio [HR] 16.6 [95% confidence interval (CI) 10.8-25.4], P < 0.0001} and diabetes versus glomerulonephritis [HR 4.03 (95% CI 2.71-6.01), P < 0.0001] increasing mortality risk.



This study highlights the frequent use of HD and the importance of transplant listing and diabetes for young adults. More than half the young adults in our cohort started renal replacement therapy on HD. One in 10 young adults were not listed for transplant by 5 years and were ∼20 times more likely to die than those who were transplanted. Diabetes as a primary renal disease was common among young adults and associated with increased mortality. Overall, almost 1 in 10 young adults had died by 5 years from the start of RRT.
UK Renal Registry, Bristol BS10 5NB, UK.|School of Social and Community Medicine, University of Bristol, Room 1.13/1.14, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK.
Alexander J
AJ
Hamilton
UK Renal Registry, Bristol BS10 5NB, UK.
Anna
A
Casula
School of Social and Community Medicine, University of Bristol, Room 1.13/1.14, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK.
Yoav
Y
Ben-Shlomo
UK Renal Registry, Bristol BS10 5NB, UK.|School of Social and Community Medicine, University of Bristol, Room 1.13/1.14, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK.
Fergus J
FJ
Caskey
Bristol Royal Hospital for Children, Bristol BS2 8BJ, UK.
Carol D
CD
Inward
D000293:Adolescent; D000328:Adult; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality* / Q000628:therapy; D016030:Kidney Transplantation / Q000401:mortality*; D008297:Male; D011379:Prognosis; D012042:Registries / Q000706:statistics & numerical data*; D017582:Renal Replacement Therapy / Q000401:mortality*; D015996:Survival Rate; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult
clinical epidemiology; dialysis; kidney transplantation; registries; survival; young adult