What increases the risk of malnutrition in Parkinson's disease?
Parkinson's disease (PD) patients are at a higher risk of malnutrition. The prevalence has been estimated to 0-24%, while 3%-60% of PD patients are reported to be at risk of malnutrition. To date, there is no clear explanation for malnutrition in these patients. The aim of this study was to determine the prevalence of malnutrition and to analyze factors that influence its appearance. The Mini Nutritional Assessment (MNA) was used to determine normal nutritional status; at risk of malnutrition; and already malnourished status. The Unified Parkinson's Disease Rating Scale (UPDRS) parts III and IV, Hoehn and Yahr scale (H&Y scale), Beck Depression Inventory (BDI), Mini Mental State Examination (MMSE), Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale - eating part (QUIP-RS) and Mini Nutritional Assessment (MNA) were used to evaluate the factors affecting patient nutritional status. Out of 96 patients, 55,2% were at risk of malnutrition, while 8,3% had already been malnourished. Age, H&Y scale, UPDRS part III, 'off' periods and depression influence negatively on MNA. More patients with 'off' periods were rigor dominant. Thyroid gland hormone therapy was related to malnutrition, while patients with normal nutritional status used ropinirole more often than pramipexole. Factors affecting nutritional status are age, motor symptoms and stage severity, 'off' states, rigidity dominant type with 'off' states, and thyroid hormone replacement therapy. Ropinirole exhibited the possible 'protective' effect against malnutrition.
Clinical Department of Neurology, Osijek University Hospital Center, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University in Osijek, Osijek, Croatia. Electronic address: svetlana.tomic@vip.hr.
Svetlana
S
Tomic
Clinical Department of Neurology, Osijek University Hospital Center, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University in Osijek, Osijek, Croatia.
Vlasta
V
Pekic
Clinical Department of Neurology, Osijek University Hospital Center, Osijek, Croatia.
Zeljka
Z
Popijac
Clinical Department of Neurology, Osijek University Hospital Center, Osijek, Croatia.
Tomislav
T
Pucic
Clinical Department of Neurology, Osijek University Hospital Center, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University in Osijek, Osijek, Croatia.
Marta
M
Petek
Clinical Department of Neurology, Osijek University Hospital Center, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University in Osijek, Osijek, Croatia.
Tihana Gilman
TG
Kuric
Clinical Department of Neurology, Osijek University Hospital Center, Osijek, Croatia.
Sanja
S
Misevic
Clinical Department of Neurology, Osijek University Hospital Center, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University in Osijek, Osijek, Croatia.
Ruzica Palic
RP
Kramaric
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000150:complications* / Q000453:epidemiology*; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology* / Q000209:etiology*; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D012737:Sex Factors; D013223:Statistics as Topic
Malnutrition; Nutritional assessment; Parkinson disease; Risk factors