Epidemiologic and clinicopathologic evaluation of patients with breast cancer referred to Ghaem Hospital from 2005 to 2014.
Introduction:The most common cancer is Breast Cancer and the first principal purpose of cancer deaths in females of 44-40 ages. The currency of three negative breast cancer involves 10-17%. his sort cancer of the breast is described by a negative receptor of estrogen, progesterone, and HER2 that is much more competitive than the other kinds and the forecast is weaker. Therefore, this research was conducted with the aim of evaluating the outcomes of the medication in patients with a triple negative sort of breast cancer about the different patients with breast cancer.Method:This historical group research was conducted by leading to the reports of all patients with breast cancer whose medication and follow-up was conducted in Hospital of Mashhad Ghaem through 2001 and 2010, their ER, PR, HER2 outcomes being reported in the files. Based on immunohistochemical records (ER, PR, HER2), patients were split into 2 collections: triple negative and another negative and the therapeutic results were analyzed among the 2 groups regarding two and five-year disease-free and throughout durability by Kaplan-Meier method. P<0.05 was regarded necessary.Results:The medicinal studies of 331 cases with breast cancer were investigated in this research. The number of members in the Triple negative collection was 101 (30.5%) and in another negative group was 230 (69.5%). The base overall durability in the triple negative was 32.48 ± 24.56 months and in another negative was 29.67 ± 22.36 months and no notable variation was recognized in the studied collections (P=0.306). Furthermore, the low disease-free durability in the triple negative group was 30.57 ± 24.56 months and in another negative was 28.21 ± 21.72 months and no important variation was recognized in the studied collections (P=0.184).Conclusion:under previously directed investigations, between all the samples of breast cancer, Triple negative had a weaker forecast and a lower durability with the cases in our research, the overall durability and disease-free longevity got were the same in 2 collections of Triple negative and another negative, and the basis of this relationship was apparently the residence of HER2 + subgroup in the non-Triple negative collection which pointed to the durability of cases in the non-Triple negative collection be similar to the Triple negative collection.
Department of Obstetrics and Gynecology, Women's Health Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
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Kadkhodayan
Department of Radiotherapy Oncology, Research Center of Solid Tumor Treatment, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
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Homaee Shandiz
Triple negative; cancer of breast; disease free survival; overall survival