First Indian report of IncX3 plasmid carryingblaNDM-7inEscherichia colifrom bloodstream infection: potential for rapid dissemination.
EnterobacteriaceaewithblaNDM-7is only infrequently observed. Self-transmissible plasmids carrying theblaNDMgene increase the dissemination of carbapenem resistance in developing countries. This study investigates the whole genome sequence of ablaNDM-7-positiveEscherichia coli. The isolate was an extended-spectrum β-lactamase producer by combined disc diffusion test and carbapenemase producer by CarbaNP method. Sequencing results revealed the isolate asE. coliST-167 with IncX3 plasmid carryingblaNDM-7in addition toblaTEM-1andblaCMY-42genes. The identification of IncX3-blaNDM-7combination is the first report in India whereblaNDM-7is known to cause higher resistance to carbapenems compared to its variants.
Department of Clinical Microbiology, Christian Medical College, Vellore, India.
N K
NK
Devanga Ragupathi
Department of Clinical Microbiology, Christian Medical College, Vellore, India.
D P
DP
Muthuirulandi Sethuvel
Department of Clinical Microbiology, Christian Medical College, Vellore, India.
R
R
Gajendiran
Department of Clinical Microbiology, Christian Medical College, Vellore, India.
J L K
JL
Daniel
Division of Epidemiology and Communicable Diseases, Indian Council of Medical Research, New Delhi, India.
K
K
Walia
Department of Clinical Microbiology, Christian Medical College, Vellore, India.
B
B
Veeraraghavan
IncX3; ST167 Escherichia coli; blaNDM-7; carbapenem resistance; whole genome sequencing