Altered resting-state hippocampal functional networks associated with chemotherapy-induced prospective memory impairment in breast cancer survivors.
In this study, we aimed to investigate the intrinsic hippocampal functional connectivity (FC) network and its relationship with prospective memory in patients with breast cancer suffering from chemotherapy-induced cognitive impairment (CICI). Thirty-four breast cancer patients before and after adjuvant chemotherapy (CB and CC, respectively) and 31 age- and education-matched cognitively normal (CN) women were recruited and subjected to a prospective memory task and a resting-state functional magnetic resonance imaging scan. Seed-based functional connectivity analysis was used to compare the hippocampal FC networks between CC and CN groups. Partial correction analysis was used to examine the association between the hippocampal FC network and prospective memory in the CC group. The cancer group that underwent chemotherapy obtained significantly poorer scores than the CN group on mini-mental state examination, verbal fluency test, digit span, and prospective memory examination. Compared to the CN group, CC group showed increased hippocampal connectivity in the frontal and parietal cortex, precuneus, posterior cingulate cortex, and the cerebellum. In addition, the increasing hippocampal FC networks were negatively correlated with prospective memory performance in the CC group. These findings suggest maladaptive hippocampal functioning as a mechanism underlying the impairment of prospective memory in patients experiencing CICI.
Department of Oncology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, China.
Huaidong
H
Cheng
Department of Oncology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, China.
Wen
W
Li
Department of Neurology, Affiliated Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Liang
L
Gong
Department of Oncology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, China.
Han
H
Xuan
Department of Oncology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, China.
Zhonglian
Z
Huang
Department of Oncology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, China.
Hong
H
Zhao
Department of Oncology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, China.
Long Sheng
LS
Wang
Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Neuropsychological Laboratory, Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Kai
K
Wang
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001931:Brain Mapping; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy; D063132:Connectome; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000209:etiology* / Q000523:psychology*; D008875:Middle Aged; D012146:Rest / Q000523:psychology*; D017741:Survivors