Microbiota and reproducibility of rodent models.
The gut microbiota (GM) plays a critical role in human health and disease. Likewise, it is becoming increasingly evident that changes or disruptions to the GM can have significant effects on animal models and their expressed phenotypes, adding a complex and important variable into basic research and preclinical studies. In this article, we review some of the most common sources of GM variability in rodent models, and discuss measures to address this variability for improved reproducibility.
Department of Veterinary Pathobiology at the University of Missouri in Columbia, Missouri.
Craig L
CL
Franklin
Department of Veterinary Pathobiology at the University of Missouri in Columbia, Missouri.
Aaron C
AC
Ericsson
D000822:Animal Husbandry; D000818:Animals; D004195:Disease Models, Animal; D000069196:Gastrointestinal Microbiome; D016998:Helicobacter; D016481:Helicobacter Infections / Q000382:microbiology / Q000662:veterinary; D023421:Models, Animal; D015203:Reproducibility of Results; D012377:Rodentia / Q000382:microbiology