Physical mechanism and modeling of heat generation and transfer in magnetic fluid hyperthermia through Néelian and Brownian relaxation: a review.
Current clinically accepted technologies for cancer treatment still have limitations which lead to the exploration of new therapeutic methods. Since the past few decades, the hyperthermia treatment has attracted the attention of investigators owing to its strong biological rationales in applying hyperthermia as a cancer treatment modality. Advancement of nanotechnology offers a potential new heating method for hyperthermia by using nanoparticles which is termed as magnetic fluid hyperthermia (MFH). In MFH, superparamagnetic nanoparticles dissipate heat through Néelian and Brownian relaxation in the presence of an alternating magnetic field. The heating power of these particles is dependent on particle properties and treatment settings. A number of pre-clinical and clinical trials were performed to test the feasibility of this novel treatment modality. There are still issues yet to be solved for the successful transition of this technology from bench to bedside. These issues include the planning, execution, monitoring and optimization of treatment. The modeling and simulation play crucial roles in solving some of these issues. Thus, this review paper provides a basic understanding of the fundamental and rationales of hyperthermia and recent development in the modeling and simulation applied to depict the heat generation and transfer phenomena in the MFH.
Nanyang Institute of Technology in Health and Medicine, Interdisciplinary Graduate School, Nanyang Technological University, Research Techno Plaza, #02-07, 50 Nanyang Drive, Singapore, 637553, Singapore. suri0011@e.ntu.edu.sg.|Lee Kong Chian School of Medicine, Nanyang Technological University, Experimental Medicine Building, Level 3, Yunnan Garden Campus, 59 Nanyang Drive, Singapore, 636921, Singapore. suri0011@e.ntu.edu.sg.|School of Mechanical and Aerospace Engineering, College of Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore. suri0011@e.ntu.edu.sg.
Suriyanto
School of Mechanical and Aerospace Engineering, College of Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
E Y K
http://orcid.org/0000-0002-5701-1080
EY
Ng
Lee Kong Chian School of Medicine, Nanyang Technological University, Experimental Medicine Building, Level 3, Yunnan Garden Campus, 59 Nanyang Drive, Singapore, 636921, Singapore.
S D
SD
Kumar
D000818:Animals; D006358:Hot Temperature; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D060526:Magnetic Fields; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry; D055585:Physical Phenomena
Bioheat transfer; Computational modeling; Magnetic fluid hyperthermia; Nanotechnology; Numerical methods; Optimization