A study on associations of single-nucleotide polymorphisms within H19 and HOX transcript antisense RNA (HOTAIR) with genetic susceptibility to rheumatoid arthritis in a Chinese population.
OBJECTIVE
The purpose of our study was to examine whether the H19 rs2839698, rs217727, and HOX transcript antisense RNA (HOTAIR) rs12826786 polymorphisms were associated with genetic susceptibility to rheumatoid arthritis (RA) in a Chinese population.


METHODS
A total of 777 participants were enrolled in this study, including 328 RA patients and 449 healthy controls. The H19 rs2839698, rs217727, and HOTAIR rs12826786 polymorphisms were detected by the ligase detection reaction-polymerase chain reaction (LDR-PCR) technology.


RESULTS
No significant difference in genotype distribution between RA patients and healthy controls was found (P = 0.38 for rs2839698; P = 0.79 for rs217727; P = 0.39 for rs12826786). The difference in allele frequencies between RA patients and controls was also non-significant (rs2839698 T versus C, P = 0.23, odds ratio (OR) = 1.15, 95% confidence interval (CI) = 0.92-1.43; rs217727 C versus T, P = 0.55, OR = 1.07, 95% CI = 0.87-1.32; and rs12826786 T versus C, P = 0.32, OR = 1.14, 95% CI = 0.88-1.47). We have also evaluated the relationships of above-mentioned polymorphisms with risk of RA under dominant model and recessive model, but non-significant evidence was found. No significant evidence was detected for the relationships of H19 rs2839698, rs217727, and HOTAIR rs12826786 polymorphisms with risk of different serotypes of RA.


CONCLUSIONS
Our results indicated that H19 rs2839698, rs217727, and HOTAIR rs12826786 polymorphisms might not be involved in the genetic background of RA in Chinese.
Department of Preventive Medicine, School of Medicine, Ningbo University, 818 Fenghua Road, 315211, Ningbo, Zhejiang, People's Republic of China.|Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 818 Fenghua Road, 315211, Ningbo, Zhejiang, People's Republic of China.
Jian-Zhe
JZ
Zhou
Department of Preventive Medicine, School of Medicine, Ningbo University, 818 Fenghua Road, 315211, Ningbo, Zhejiang, People's Republic of China.|Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 818 Fenghua Road, 315211, Ningbo, Zhejiang, People's Republic of China.
Jing-Jing
JJ
Li
Department of Preventive Medicine, School of Medicine, Ningbo University, 818 Fenghua Road, 315211, Ningbo, Zhejiang, People's Republic of China.|Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 818 Fenghua Road, 315211, Ningbo, Zhejiang, People's Republic of China.
Dong-Jin
DJ
Hua
Department of Preventive Medicine, School of Medicine, Ningbo University, 818 Fenghua Road, 315211, Ningbo, Zhejiang, People's Republic of China.|Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 818 Fenghua Road, 315211, Ningbo, Zhejiang, People's Republic of China.
Si-Chao
SC
Huang
Department of Preventive Medicine, School of Medicine, Ningbo University, 818 Fenghua Road, 315211, Ningbo, Zhejiang, People's Republic of China.|Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 818 Fenghua Road, 315211, Ningbo, Zhejiang, People's Republic of China.
Qing-Qing
QQ
Sun
Department of Rheumatology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, 59 Liuting Road, 315010, Ningbo, Zhejiang, People's Republic of China.
Hua
H
Huang
Department of Rheumatology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, 59 Liuting Road, 315010, Ningbo, Zhejiang, People's Republic of China.
Xia-Fei
XF
Xin
Department of Preventive Medicine, School of Medicine, Ningbo University, 818 Fenghua Road, 315211, Ningbo, Zhejiang, People's Republic of China. cenhan@nbu.edu.cn.|Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 818 Fenghua Road, 315211, Ningbo, Zhejiang, People's Republic of China. cenhan@nbu.edu.cn.
Han
H
Cen
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding / Q000235:genetics*
C094335:H19 long non-coding RNA; C561566:HOTAIR long untranslated RNA, human; D062085:RNA, Long Noncoding
H19; HOTAIR; Long non-coding RNA; Polymorphism; Rheumatoid arthritis