Network analysis of Urocortins.
OBJECTIVE
Urocortins (Ucns), members of corticotropin releasing factor family, play critical roles in a number of pathological and physiological conditions. Many proteins have been reported to participate in Ucns signaling pathways, which formed complex interaction networks.


METHODS
STITCH ('search tool for interactions of chemicals') is an interaction network database that provides exploration of the known and predicted interactions among large sets of chemicals and proteins.


RESULTS
In this study, using STITCH, interaction networks of Ucns were constructed by database mining, and then their topological parameters and important nodes were analyzed by network related tools. This may help a quick and thorough overview of the Ucns mechanisms underlying in a visual format.
Department of Traditional Chinese Medicine, Zhejiang Pharmaceutical College, Ningbo, China.
Shao-Jun
SJ
Chen
D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D016208:Databases, Factual; D006801:Humans; D060066:Protein Interaction Maps; D018019:Receptors, Corticotropin-Releasing Hormone / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D054832:Urocortins / Q000378:metabolism*
D018019:Receptors, Corticotropin-Releasing Hormone; D054832:Urocortins; D003346:Corticotropin-Releasing Hormone