Precursor-B-cell-ALL leukemia cutis resembling lipomas: an atypical presentation of a rare entity and a review of the literature.
Leukemia cutis (LC) is an extramedullary manifestationof leukemia owing to cutaneous infiltration ofneoplastic cells resulting in characteristic firm,erythematous nodules. Most cases of LC occur inpatients with acute myelogenous leukemia andchronic myelogenous leukemia. However in rarecases, LC has presented in patients with acutelymphoblastic leukemia (ALL). In these rare ALLassociatedcases, only 10 cases of precursor-B-ALL(pre-B-ALL) have been described in the literature.We report a case of a 22-year-old man with relapsingpre-B-ALL who presented with a 4-day history ofmultiple asymptomatic, soft, dome-shaped, lipomalikemounds on his scalp and chin, which exhibitedcutaneous involvement by leukemic cells. To date, thisis the first case of pre-B-ALL associated leukemia cutispresenting as soft, dome-shaped mounds resemblinglipomas.
Department of Dermatology, Baylor College of Medicine, Houston, Texas. ymhuang@bcm.edu.
Yuan Yu Michael
YY
Huang
Melinda
M
Liu
Jennifer S
JS
Ruth
Silvia
S
Potenziani
Sylvia
S
Hsu
D003937:Diagnosis, Differential; D006801:Humans; D017254:Leukemic Infiltration / Q000175:diagnosis* / Q000473:pathology; D008067:Lipoma / Q000175:diagnosis*; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000473:pathology; D012535:Scalp; D012867:Skin / Q000473:pathology*; D055815:Young Adult