High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients.
The neutrophil-to-lymphocyte ratio (NLR) is a novel simple biomarker of inflammation. It has emerged as a predictor of poor prognosis in cancer and cardiovascular disease in general population. But little was known of its prognostic value in chronic hemodialysis (HD) patients. Here we investigated the association between NLR and cardiovascular risk markers, including increased pulse pressure (PP), left ventricular mass index (LVMI) and intima-media thickness (IMT), and mortality in HD patients. Two hundred and sixty-eight HD patients were enrolled in this study and were followed for 36 months. The primary end point was all-cause mortality and cardiovascular mortality. Multivariable Cox regression was used to calculate the adjusted hazard ratios for NLR on all-cause and cardiovascular survival. We pinpointed that higher NLR in HD patients was a predictor of increased PP, LVMI, and IMT; HD patients with higher NLR had a lower survival at the end of the study; furthermore, high NLR was an independent predictor of all-cause and cardiovascular mortality when adjusted for other risk factors. In conclusion, higher NLR in HD patients was associated with cardiovascular risk factors and mortality.
Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Nephrology Faculty, Capital Medical University, Beijing, China.
Han
0000-0003-2869-6911
H
Li
Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Nephrology Faculty, Capital Medical University, Beijing, China.
Xiangxue
0000-0003-3528-582X
X
Lu
Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Nephrology Faculty, Capital Medical University, Beijing, China.
Ruifang
R
Xiong
Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Nephrology Faculty, Capital Medical University, Beijing, China.
Shixiang
0000-0002-5500-4119
S
Wang
D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood* / Q000276:immunology / Q000401:mortality*; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology* / Q000502:physiology; D016016:Proportional Hazards Models; D006435:Renal Dialysis; D012307:Risk Factors; D055815:Young Adult