[Assessment of predictive factors for survival in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy].
Objective:To evaluate the clinical predictive factors for survival prognosis in patients with locally advanced rectal cancer after neoadjuvant chemoradiotheraphy.Methods:The study included 87 patients with middle and lower locally advanced rectal cancer, who underwent neoadjuvant chemoradiotheraphy followed by radical surgery between April 2007 and May 2015. The clinical factors associated with 3-year disease-free survival (DFS) and overall survival (OS) were analyzed.Kaplan-Meier analysis of disease-free survival and overall survival was performed for all patients.Results:The 3-year DFS was significantly improved in patients with negative lymph node(95.2% vs 69.5%, χ(2)=8.642,P=0.003). The 3-year OS was better in the patients with lower serum level of pre- chemoradiotheraphy carcino-embryonic antigen (CEA)(90.9% vs 66.7%, χ(2)=8.820,P=0.003). Cox regression multivariate analysis revealed that serum level of pre-chemoradiotheraphy CEA was an independent predictive factor for 3-year OS(P=0.035).Conclusion:Serum level of pre- chemoradiotheraphy CEA is an independent risk factor for 3-year OS.
Department of General Surgery, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
G J
GJ
Wu
T
T
Yu
W W
WW
Jia
Q
Q
An
G
G
Xiao
X
X
Wang
D059248:Chemoradiotherapy; D018572:Disease-Free Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D015999:Multivariate Analysis; D020360:Neoadjuvant Therapy; D011379:Prognosis; D012004:Rectal Neoplasms / Q000628:therapy*; D012007:Rectum; D012307:Risk Factors
Neoadjuvant chemoradiotherapy; Prognosis; Rectal neoplasms