Adverse prognostic impact ofTGFB1T869C polymorphism in non-small-cell lung cancer.
Previously, several polymorphisms inTGFB1have been identified in non-small-cell lung cancer (NSCLC), and the variants, C-509T, T869C, and G915C, have been demonstrated to associate with higher circulating levels of TGF-β1. However, little is known about the prognostic value of TGF-β1 polymorphisms in cancers. In this study, by genotyping the TGF-β1 T869C polymorphism in a total of 261 patients with NSCLC using DNA from blood lymphocytes, we first found that NSCLC patients, especially those with allele C carriers, had significantly higher serum TGF-β1 levels than healthy individuals. By using chi-square (χ2) test and Fisher's exact test, we noticed that TC/CC genotypes were positively correlated with smoking, clinical TNM stage, lymph node, and distant metastasis in NSCLC patients. Kaplan-Meier analysis showed that patients with TT genotype had a better overall survival than the allele C carriers (TC + CC). Finally, multivariate analysis confirmed histology, lymph node, and distant metastasis but not T869C polymorphism as independent prognostic factors for NSCLC. Taken together, our data, as a proof of principle, suggest that T869C polymorphism inTGFB1may act as a genetic modifier in NSCLC progression and a promising prognostic marker of survival in NSCLC patients.
Department of Respiratory, The First Affiliated Hospital of Harbin Medical University.
Yulan
Y
Sang
Department of Respiratory, The First Affiliated Hospital of Harbin Medical University.
Xin
X
Bi
Department of Respiratory, The Fourth Hospital of Harbin, Harbin, People's Republic of China.
Yan
Y
Liu
Department of Respiratory, The First Affiliated Hospital of Harbin Medical University.
Wei
W
Zhang
Department of Respiratory, The First Affiliated Hospital of Harbin Medical University.
Dongjie
D
Wang
genotype and multivariate analysis; prognosis; single-nucleotide polymorphisms