Experimental Evolution to Study Virus Emergence.
Understanding how viruses adapt to new environments and acquire new phenotypes is critical for developing comprehensive responses to outbreaks. By studying the emergence of vaccine-derived poliovirus outbreaks, Stern et al. describe how a combination of sequence analysis and experimental evolution can be used to reveal adaptive pathways.
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: grubaugh@scripps.edu.
Nathan D
ND
Grubaugh
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Translational Science Institute, La Jolla, CA 92037, USA. Electronic address: andersen@scripps.edu.
Kristian G
KG
Andersen
D005075:Biological Evolution; D004196:Disease Outbreaks; D011051:Poliomyelitis / Q000453:epidemiology*; D017955:Poliovirus / Q000235:genetics; D011055:Poliovirus Vaccine, Oral
D011055:Poliovirus Vaccine, Oral