Interactions between three typical endocrine-disrupting chemicals (EDCs) in binary mixtures exposure on myocardial differentiation of mouse embryonic stem cell.
In recent years, various kinds of endocrine-disrupting chemicals (EDCs) have been detected in human blood and urine. Thus, it was important to investigate the combined toxicity effect of EDCs. In the present study, we evaluated the individual and combined developmental toxicities of three classic EDCs: perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and bisphenol A (BPA) by embryonic stem cell test (EST). The similarities and differences between combination of same chemical group as well as different chemical groups were investigated in this research. Our results showed that the three compounds were all classified as weak embryotoxicity. The results of co-exposure revealed that there was synergistic action in combination of PFOS and BPA on myocardial differentiation. However, in all endpoints, the combined effects between PFOA with PFOS or BPA were both additive action. Therefore, we concluded that the additive effects were found in most different EDC mixtures whether they had similar structure or not. On the other hand, synergistic action was observed in a mixture of EDCs that belonged to a different chemical groups.
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China. Electronic address: zhouren77@126.com.
Ren
R
Zhou
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China.
Wei
W
Cheng
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China.
Yan
Y
Feng
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China.
Hongying
H
Wei
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China.
Fan
F
Liang
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China; The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, PR China; MOE-Shanghai Key Laboratory of Children's Environmental Health, Shanghai, 200092, PR China. Electronic address: wangyan@shsmu.edu.cn.
Yan
Y
Wang
D017738:Alkanesulfonic Acids / Q000494:pharmacology*; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D002210:Caprylates / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D004347:Drug Interactions; D052244:Endocrine Disruptors / Q000494:pharmacology*; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology; D005466:Fluorocarbons / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D000066450:Mouse Embryonic Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D000098826:Bisphenol A Compounds
D017738:Alkanesulfonic Acids; D001559:Benzhydryl Compounds; D002210:Caprylates; D052244:Endocrine Disruptors; D004968:Estrogens, Non-Steroidal; D005466:Fluorocarbons; D010636:Phenols; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid; C006780:bisphenol A; D000098826:Bisphenol A Compounds
Bisphenol A; Combined toxicity; Embryonic stem cell test; Perfluorinated compounds