Molecular Mechanisms Mediating Involvement of Glial Cells in Brain Plastic Remodeling in Epilepsy.
In this review we summarize published data on the involvement of glial cells in molecular mechanisms underlying brain plastic reorganization in epilepsy. The role of astrocytes as glial elements in pathological plasticity in epilepsy is discussed. Data on the involvement of aquaporin-4 in epileptogenic plastic changes and on participation of microglia and extracellular matrix in dysregulation of synaptic transmission and plastic remodeling in epileptic brain tissue are reviewed.
Research Center of Neurology, Department of Brain Research, Moscow, 105064, Russia. khaspekleon@mail.ru.
L G
LG
Khaspekov
L E
LE
Frumkina
D000818:Animals; D051401:Aquaporin 4 / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D004827:Epilepsy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009457:Neuroglia / Q000378:metabolism* / Q000473:pathology; D009473:Neuronal Plasticity
C496030:AQP4 protein, human; D051401:Aquaporin 4