Difluoromethylcarbene for iron-catalyzed cyclopropanation.
Difluoroethylsulfonium salt, Ph2S+CH2CF2H OTf-, was developed into a convenient difluoromethylcarbene reagent for the iron-catalyzed cyclopropanation of terminal olefins, giving various difluoromethyl-cyclopropanes with excellent diastereoselectivities and in high yields.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chmistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China. jlin@sioc.ac.cn jchxiao@sioc.ac.cn.
Yaya
Y
Duan
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chmistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China. jlin@sioc.ac.cn jchxiao@sioc.ac.cn.
Jin-Hong
http://orcid.org/0000-0002-7000-9540
JH
Lin
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chmistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China. jlin@sioc.ac.cn jchxiao@sioc.ac.cn.
Ji-Chang
JC
Xiao
Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK.
Yu-Cheng
YC
Gu