Rapid Influenza Diagnostic Tests Improve Suitability of Antiviral Treatment in Hospitalized Children.
Influenza may have a complicated course in young children. The aim of the study was to analyze the suitability of influenza treatment among children younger than 5 years hospitalized due to an influenza-like illness. We conducted a comparison of the treatment among children hospitalized in two consecutive years: 2015, when no rapid influenza diagnostic tests (RIDT) were in use, and 2016, when RIDT were implemented into a routine practice in the pediatric ward. In both seasons, nasopharyngeal swabs were collected and examined with real time qRT-PCR. In the 2015 season, influenza was diagnosed in 15/52 (28 %) children and none of them received oseltamivir, while 14/15 (93 %) patients received antibiotics. In the 2016 season, influenza was diagnosed in 11/63 (17 %) children, 7/11 (64 %) of them received oseltamivir and another 7/11 (64 %) received antibiotics. In four cases antibiotics overlapped oseltamivir. These differences in the use of oseltamivir and antibiotics were statistically significant (p < 0.05). We conclude that the implementation of RIDT improves the suitability of influenza treatment and decreases the frequency of antibiotic therapy. RIDT should be available in pediatric departments to optimize influenza treatment.
Department of Social Medicine and Public Health, Medical University of Warsaw, 3 Oczki Street, 02-007, Warsaw, Poland. aitsch@wum.edu.pl.
Aneta
A
Nitsch-Osuch
Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Warsaw, Poland.
Ernest
E
Kuchar
Department of Social Medicine and Public Health, Medical University of Warsaw, 3 Oczki Street, 02-007, Warsaw, Poland.
Izabela
I
Gołębiak
Department of Social Medicine and Public Health, Medical University of Warsaw, 3 Oczki Street, 02-007, Warsaw, Poland.
Krzysztof
K
Kanecki
Department of Social Medicine and Public Health, Medical University of Warsaw, 3 Oczki Street, 02-007, Warsaw, Poland.
Patryk
P
Tarka
Department of Influenza Research, National Influenza Center, National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland.
Lidia B
LB
Brydak
D000998:Antiviral Agents / Q000008:administration & dosage*; D002673:Child, Hospitalized; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D009980:Influenza A virus / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D007251:Influenza, Human / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D008297:Male; D053139:Oseltamivir / Q000008:administration & dosage*
D000998:Antiviral Agents; D053139:Oseltamivir
Antibiotic Therapy; Antiviral Treatment; Children; Hospitalization; Influenza-Like Illness; Neuraminidase Inhibitors