Impact of therapeutic food compared to oral nutritional supplements on nutritional outcomes in mildly underweight healthy children in a low-medium income society.
Therapeutic foods (RUTF) are used to treat severe acute malnutrition in children 5 years and under in low and middle income countries (LMI), while liquid nutritional supplements (ONS) are used in affluent societies. With globalisation and economic growth in LMI, there will be an inclination to move towards practices applied in affluent countries. This study compared the effect of supplementation with a RUTF and an ONS, on nutritional outcomes in mildly underweight children.



68 Pakistani (5-10 y), mildly underweight (weight Z-score: -2 to -1) children randomly received either RUTF or ONS (500 kcal/day), in addition to their habitual diet for four weeks. Weight, height, skinfolds and their changes during intervention, were compared between the two groups and at follow up, post-supplementation.



All nutritional outcomes and height improved with both supplements, but net weight gain (kg) and changes from baseline for weight, height, triceps and sub-scapular thickness Z-scores did not differ between the two supplements [mean (SD), RUTF vs ONS; weight gain (kg), 0.59 (0.30) vs 0.65 (0.42), p = 0.483; weight Z-score, 0.12 (0.09) vs 0.15 (0.13), p = 0.347; height Z-score, 0.04 (0.08) vs 0.04 (0.08), p = 0.908; triceps Z-score, 0.29 (0.24) vs 0.31 (0.23), p = 0.796; subscapular Z-score, 0.37 (0.29) vs 0.31 (0.25), p = 0.385]. Weight gain (0.6 kg) for both groups was lower than anticipated (2 kg). Post-supplementation, there was a tendency for weight and height Z-score to return to baseline.



RUTF and ONS are equivalently effective in improving nutritional outcomes in children 5 to 10 y at risk of malnutrition but the observed benefit is less than expected and not sustainable.



This trial was registered at www.controlled-trials.com reference: ISRCTN51555749.



This trial was registered at www.controlled-trials.com reference: ISRCTN51555749.
School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK; Khyber Medical University Peshawar, Pakistan.
Sadia
S
Fatima
School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
Dalia
D
Malkova
School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
Charlotte
C
Wright
School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK. Electronic address: Konstantinos.Gerasimidis@glasgow.ac.uk.
Konstantinos
K
Gerasimidis
D017028:Caregivers; D002648:Child; D015362:Child Nutrition Disorders / Q000517:prevention & control; D002675:Child, Preschool; D003258:Consumer Behavior; D004032:Diet; D019587:Dietary Supplements; D005260:Female; D005526:Food, Formulated / Q000032:analysis; D006801:Humans; D008297:Male; D044623:Nutrition Therapy / Q000379:methods*; D009753:Nutritive Value; D010154:Pakistan; D011203:Poverty; D013851:Thinness / Q000178:diet therapy*; D016896:Treatment Outcome; D015430:Weight Gain
Malnutrition; Oral nutritional supplements; Ready to use therapeutic food