Synthesis of 2,5-Disubstituted Furans from Sc(OTf)3Catalyzed Reaction of Aryl Oxiranediesters with γ-Hydroxyenones.
A convenient synthesis of 2,5-disubstituted furan was developed by employing donor-acceptor oxiranes in a new reaction with γ-hydroxyenones. Sc(OTf)3was found to be the best catalyst, and 2,5-disubstituted furans are obtained in moderate to good yields under mild reaction conditions. The scope of the reaction is quite decent, allowing for the synthesis of disubstituted furans having aryl and heteroaromatic groups.
Department of Chemistry, Indian Institute of Technology Guwahati , North Guwahati, Assam 781039, India.
Keshab
K
Mondal
Department of Chemistry, Indian Institute of Technology Guwahati , North Guwahati, Assam 781039, India.
Subhas Chandra
0000-0002-7581-1831
SC
Pan