Exploring MicroRNAs on NIX-Dependent Mitophagy.
The dysregulation of autophagy is implicated in many pathological disorders including infections, aging, neurodegenerative diseases, and cancer. Autophagy can be precisely controlled both transcriptionally and translationally. Accumulating evidences show that the autophagy response is regulated by microRNAs, which therefore becomes subject area of interest in recent years. Herein, we give a brief introduction of the recent advancement in the regulation of microRNA on autophagy, and then we focus on the microRNA regulation of the mitophagy receptor, NIX. Finally, we present the methodology on how to study it in detail.
Institute of Neurology, Guangdong Key Laboratory of Age-related Cardiac-cerebral Vascular Disease, The Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.|Medical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wen
W
Li
Institute of Neurology, Guangdong Key Laboratory of Age-related Cardiac-cerebral Vascular Disease, The Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.|Medical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hao
H
Chen
Institute of Neurology, Guangdong Key Laboratory of Age-related Cardiac-cerebral Vascular Disease, The Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.|Medical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Shupeng
S
Li
Institute of Neurology, Guangdong Key Laboratory of Age-related Cardiac-cerebral Vascular Disease, The Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.|Medical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Guanghong
G
Lin
Institute of Neurology, Guangdong Key Laboratory of Age-related Cardiac-cerebral Vascular Disease, The Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China. feng_du@foxmail.com.|The Department of Developmental Biology, Harvard School of Dental Medicine, Harvard Medical School, Boston, MA, USA. feng_du@foxmail.com.|Medical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. feng_du@foxmail.com.
Du
D
Feng
D000818:Animals; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics*; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism; D063306:Mitophagy; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D034622:RNA Interference; D012333:RNA, Messenger / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
C116838:BNIP3L protein, human; D008565:Membrane Proteins; D035683:MicroRNAs; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D025521:Tumor Suppressor Proteins
Autophagy; BNIP3L; LC3; MicroRNAs; Mitophagy; NIX