Serum Endocan as a Predictive Marker for Decreased Urine Volume in Peritoneal Dialysis Patients.
BACKGROUND Endocan is expressed in vascular endothelial cells, and its expression is enhanced following endothelial injury via inflammatory cytokines. Subsequently, endocan is secreted into the circulation. Thus, serum endocan levels are considered a marker of endothelial injury. However, to the best of our knowledge, no data on the serum endocan levels in peritoneal dialysis (PD) patients are available. MATERIAL AND METHODS This study included 21 PD patients who underwent peritoneal equilibration test (PET) more than once between 2011 and 2015. Serum samples were collected from each patient, and the 24-h urine volume was measured at the time of PET. Serum endocan levels were measured using enzyme-linked immunosorbent assay (ELISA) at the time of the first PET, and their relationship with clinical data or the extent of urine volume decline (mL/year) was analyzed retrospectively. RESULTS Serum endocan levels were positively correlated with proteinuria level, serum creatinine level, serum tumor necrosis factor (TNF)-α level, β2-microglobulin level, and PD drainage volume, but not with urine volume at baseline. The extent of decline in urine volume was significantly associated with serum endocan level, proteinuria level, serum creatinine level, and serum TNF-α level at baseline in a simple linear regression analysis. Moreover, multiple linear regression analysis showed that the serum endocan level and proteinuria level at baseline were independent predictors for the extent of decline in urine volume. CONCLUSIONS The results of this study indicate that serum endocan level and proteinuria level may be useful predictive markers for decreased urine volume in PD patients.
Department of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.|Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.
Satoru
S
Oka
Department of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.|Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.|Medical Educational Development Center, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Yoko
Y
Obata
Clinical Research Center, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Shuntaro
S
Sato
Department of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.|Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.
Kenta
K
Torigoe
Department of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.|Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.
Miki
M
Sawa
Department of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Shinichi
S
Abe
Department of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Kumiko
K
Muta
Department of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.|Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.
Yuki
Y
Ota
Department of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.|Department of Blood Purification, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Mineaki
M
Kitamura
Department of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Satoko
S
Kawasaki
Department of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Misaki
M
Hirose
Department of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Tadashi
T
Uramatsu
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.
Hiroshi
H
Mukae
Department of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.|Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.
Tomoya
T
Nishino
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003401:Creatine / Q000097:blood; D042783:Endothelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D010530:Peritoneal Dialysis / Q000009:adverse effects / Q000379:methods*; D011507:Proteinuria / Q000652:urine*; D011509:Proteoglycans / Q000097:blood*; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014554:Urination / Q000502:physiology
D015415:Biomarkers; C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans; D014409:Tumor Necrosis Factor-alpha; D003401:Creatine