Bioactive silicon nitride: A new therapeutic material for osteoarthropathy.
While the reciprocity between bioceramics and living cells is complex, it is principally governed by the implant's surface chemistry. Consequently, a deeper understanding of the chemical interactions of bioceramics with living tissue could ultimately lead to new therapeutic strategies. However, the physical and chemical principles that govern these interactions remain unclear. The intricacies of this biological synergy are explored within this paper by examining the peculiar surface chemistry of a relatively new bioceramic, silicon nitride (Si3N4). Building upon prior research, this paper aims at obtaining new insights into the biological interactions between Si3N4and living cells, as a consequence of the off-stoichiometric chemical nature of its surface at the nanometer scale. We show here yet unveiled details of surface chemistry and, based on these new data, formulate a model on how, ultimately, Si3N4influences cellular signal transduction functions and differentiation mechanisms. In other words, we interpret its reciprocity with living cells in chemical terms. These new findings suggest that Si3N4might provide unique new medicinal therapies and effective remedies for various bone or joint maladies and diseases.
Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, 606-8126 Kyoto, Japan.|Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.|The Center for Advanced Medical Engineering and Informatics, Osaka University, Yam daoka, Suita, 565-0871 Osaka, Japan.
Giuseppe
G
Pezzotti
Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, 606-8126 Kyoto, Japan.
Elia
E
Marin
Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.
Tetsuya
T
Adachi
Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, 606-8126 Kyoto, Japan.
Alfredo
A
Rondinella
Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, 606-8126 Kyoto, Japan.
Francesco
F
Boschetto
Department of Medical Engineering for Treatment of Bone and Joint Disorders, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0854, Japan.
Wenliang
W
Zhu
Department of Medical Engineering for Treatment of Bone and Joint Disorders, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0854, Japan.
Nobuhiko
N
Sugano
Amedica Corporation, 1885 West 2100 South, Salt Lake City, UT 84119, United States.
Ryan M
RM
Bock
Amedica Corporation, 1885 West 2100 South, Salt Lake City, UT 84119, United States.
Bryan
B
McEntire
Amedica Corporation, 1885 West 2100 South, Salt Lake City, UT 84119, United States.|Department of Orthopaedic Surgery, University of Missouri, Columbia, MO 65212, United States.
Sonny B
SB
Bal
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D002460:Cell Line; D002470:Cell Survival; D002478:Cells, Cultured; D006801:Humans; D008422:Materials Testing; D018613:Microscopy, Confocal; D008954:Models, Biological; D010003:Osteoarthritis / Q000628:therapy; D017655:Silicon Compounds / Q000737:chemistry / Q000627:therapeutic use; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013499:Surface Properties
D001672:Biocompatible Materials; D017655:Silicon Compounds; C032734:silicon nitride