Alveolar soft-part sarcoma of the mediastinum: A case report.
We report a 53-year-old man with metastases of alveolar soft-part sarcoma originated from the mediastinum. He was hospitalized due to lower extremities' paralysis. Computed tomography scan findings revealed multiple nodules of bilateral lungs, swollen mediastinal lymph nodes, and osteolysis of thoracic vertebrae. We performed spinal decompression and biopsy from vertebra. And, we finally diagnosed this case as metastases of mediastinal alveolar soft-part sarcoma which was removed 10 years ago. Alveolar soft-part sarcoma is rare tumor accounted for 0.5%-1.0% of soft tissue sarcoma that often occurs primarily in the lower extremities and trunk. It is difficult to distinguish between alveolar soft-part sarcoma and paraganglioma, renal cell carcinoma and granular cell tumor morphologically. Periodic acid-Schiff stain and immunohistochemical staining ofASPL-TFE3are useful in making a definitive diagnosis of alveolar soft-part sarcoma. This case is a rare case of alveolar soft-part sarcoma originated in the mediastinum with local recurrence and distant metastases 10 years after the initial surgery.
Respiratory Disease Center, Yokohama City University Medical Center, Yokohama, Japan.
Yohei
Y
Kameda
Respiratory Disease Center, Yokohama City University Medical Center, Yokohama, Japan.
Teppei
T
Nishii
Respiratory Disease Center, Yokohama City University Medical Center, Yokohama, Japan; Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Masahiro
M
Tsuboi
Respiratory Disease Center, Yokohama City University Medical Center, Yokohama, Japan.
Hiromasa
H
Arai
Respiratory Disease Center, Yokohama City University Medical Center, Yokohama, Japan.
Kenji
K
Inui
Respiratory Disease Center, Yokohama City University Medical Center, Yokohama, Japan.
Takeshi
T
Kaneko
Pathology Division, Department of Clinical Research, National Hospital Organization Hakodate Hospital, Hakodate, Japan.
Noriko
N
Kimura
Division of Endocrinology, Metabolism and Hypertension, Kyoto Medical Center, Kyoto, Japan.
Mitsuhide
M
Naruse
Department of Surgery, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Munetaka
M
Masuda
ASPL-TFE3; Alveolar soft-part sarcoma; differential diagnosis; mediastinum tumor; recurrence