Nicotinamide for skin cancer chemoprevention.
Nicotinamide (vitamin B3) has a range of photoprotective effects in vitro and in vivo; it enhances DNA repair, reduces UV radiation-induced suppression of skin immune responses, modulates inflammatory cytokine production and skin barrier function and restores cellular energy levels after UV exposure. Pharmacological doses of nicotinamide have been shown to reduce actinic keratoses and nonmelanoma skin cancer incidence in high-risk individuals, making this a nontoxic and accessible option for skin cancer chemoprevention in this population.
Discipline of Dermatology, Central Clinical School, University of Sydney at Royal Prince Alfred Hospital and Melanoma Institute Australia, Sydney, Australia.
Diona L
DL
Damian
D002280:Basal Cell Carcinoma / Q000517:prevention & control*; D002294:Carcinoma, Squamous Cell / Q000517:prevention & control*; D004260:DNA Repair / Q000187:drug effects; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects / Q000528:radiation effects; D055623:Keratosis, Actinic / Q000188:drug therapy; D008545:Melanoma / Q000517:prevention & control*; D009536:Niacinamide / Q000494:pharmacology / Q000627:therapeutic use*; D016377:Organ Transplantation; D012878:Skin Neoplasms / Q000517:prevention & control*; D014466:Ultraviolet Rays / Q000009:adverse effects; D014803:Vitamin B Complex / Q000494:pharmacology / Q000627:therapeutic use*
D014803:Vitamin B Complex; D009536:Niacinamide
basal cell carcinoma; melanoma; niacinamide; squamous cell carcinoma; vitamin B3