Multimodality Treatment of Gastric Lymphoma.
Gastric lymphoma is rare, accounting for 3% of gastric neoplasms and 10% of lymphomas. Treatment should be stratified based on histologic type, stage, Helicobacter pylori infection, and t(11;18) translocation status. Surgery is no longer a mainstay for treatment and should be reserved for rare situations such as perforation, fistula formation, and severe bleeding. Multimodal treatment, including H pylori eradication, radiation therapy, chemotherapy, and immunotherapy, should be provided as appropriate and can result in excellent outcomes.
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Unit 1484, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Naruhiko
N
Ikoma
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Unit 1484, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Brian D
BD
Badgwell
Acute Care Services, The University of Texas MD Anderson Cancer Center, Unit 1485, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address: pmansfie@mdanderson.org.
Paul F
PF
Mansfield
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D016481:Helicobacter Infections / Q000517:prevention & control; D016480:Helicobacter pylori; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000628:therapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000628:therapy*; D009367:Neoplasm Staging / Q000379:methods; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000628:therapy*
Chemotherapy; Helicobacter pylori infection; Primary gastric lymphoma; Radiation therapy; Surgery