Echinodorus grandiflorus: Ethnobotanical, phytochemical and pharmacological overview of a medicinal plant used in Brazil.
Echinodorus grandiflorus (Cham. & Schltdl.) Micheli is a native Brazilian species used in traditional practices for the treatment of several conditions such as inflammatory diseases, arthritis and hypertension. Through a systematic review of the accumulated knowledge about the species E. grandiflorus, the botanical, phytochemistry, ethnobotanical and pharmacological properties of this medicinal plant demonstrates its potential to naturally provide anti-inflammatory and anti-oxidant with a special emphasis on anti-hypertensive and cardioprotective effects. The body of literature reports that the chemical composition of crude E. grandiflorus extracts are notably composed of diterpenoids and flavonoids metabolites. Pharmacological studies have shown that oral treatments using the hydroalcoholic extracts of leaves from this plant has a significant anti-inflammatory, anti-hypertensive, diuretic and cardioprotective effects in rats with no toxicity. The holistic activities of complex extracts are corroborated by the individuals mechanisms of action, as well as, synergistic benefits attributed to the isolated chemical major constituents in this species. In light of the serious health concerns ascribed, it is important to investigate medicinal plant species with histories of traditional use for circulatory problems to meet the growing demands by scientifically validating their use and safety.
Fundação Oswaldo Cruz (FIOCRUZ), Departamento de Produtos Naturais, Laboratório de Produtos Naturais, PN3, Farmanguinhos, CEP 21041-250, Rua Sizenando Nabuco, 100, Rio de Janeiro, RJ, Brazil. Electronic address: andremarques@far.fiocruz.br.
André M
AM
Marques
Fundação Oswaldo Cruz (FIOCRUZ), Centro de Desenvolvimento Tecnológico em Saúde (CDTS), Rio de Janeiro, Brazil.
D William
DW
Provance
Instituto de Pesquisas de Produtos Naturais Walter Mors (IPPN), Universidade Federal do Rio de Janeiro, CEP 21.941-590, Rio de Janeiro, RJ, Brazil.
Maria Auxiliadora C
MAC
Kaplan
Fundação Oswaldo Cruz (FIOCRUZ), Departamento de Produtos Naturais, Laboratório de Produtos Naturais, PN3, Farmanguinhos, CEP 21041-250, Rua Sizenando Nabuco, 100, Rio de Janeiro, RJ, Brazil.
Maria Raquel
MR
Figueiredo
D034901:Alismataceae / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001938:Brazil; D006801:Humans; D064209:Phytochemicals / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D064209:Phytochemicals; D010936:Plant Extracts
Anti-hypertensive; Chapéu de couro; Echinodorus grandiflorus; Hypertension; Leather hat; Medicinal plants