YCl3Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats.
The pollutants rare earth elements (REEs) have posed great threats to human health. To investigate the cytotoxicity of yttrium (Y), a model that rats have free access to water containing YCl3for 6 months is utilized. The results showed that YCl3treatment promoted neuronal cell apoptosis by upregulating the proapoptotic factors Bax, caspase-3, Cytoc, and DAPK and by downregulating the antiapoptotic factors Bcl-2 and XIAP at both mRNA and protein levels. Conclusively, YCl3exhibited cytotoxicity and promoted neuronal cell death by the induction of apoptotic pathways.
College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
Yechun
Y
Ding
College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
Yuantong
Y
Tian
College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
Zhaoyi
Z
Zeng
School of Basic Medicine, Gannan Medical University, Ganzhou 341000, China.
Ping
P
Shuai
School of Basic Medicine, Gannan Medical University, Ganzhou 341000, China.
Haiying
H
Lan
School of Basic Medicine, Gannan Medical University, Ganzhou 341000, China.
Xianshen
X
Zhu
The Third Affiliated Hospital, Gannan Medical University, Ganzhou 341000, China.
Yi
Y
Zhong
College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
Longhuo
0000-0002-3899-9599
L
Wu
Research Department, Gannan Medical University, Ganzhou 341000, China.
Xiaona
0000-0002-4612-4506
X
Fan
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000096:biosynthesis; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D064550:Death-Associated Protein Kinases / Q000096:biosynthesis; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D009474:Neurons / Q000187:drug effects*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015019:Yttrium / Q000633:toxicity*; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis
C494826:BAX protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D014874:Water Pollutants, Chemical; D051028:bcl-2-Associated X Protein; C064782:yttrium chloride; D015019:Yttrium; C579096:DAPK1 protein, human; D064550:Death-Associated Protein Kinases; D053148:Caspase 3