Regulation of Coronary Blood Flow.
The heart is uniquely responsible for providing its own blood supply through the coronary circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of dedicated research, is understood to be dictated through multiple mechanisms that include extravascular compressive forces (tissue pressure), coronary perfusion pressure, myogenic, local metabolic, endothelial as well as neural and hormonal influences. While each of these determinants can have profound influence over myocardial perfusion, largely through effects on end-effector ion channels, these mechanisms collectively modulate coronary vascular resistance and act to ensure that the myocardial requirements for oxygen and substrates are adequately provided by the coronary circulation. The purpose of this series of Comprehensive Physiology is to highlight current knowledge regarding the physiologic regulation of coronary blood flow, with emphasis on functional anatomy and the interplay between the physical and biological determinants of myocardial oxygen delivery. © 2017 American Physiological Society. Compr Physiol 7:321-382, 2017.
Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN.
Adam G
AG
Goodwill
California Medical Innovations Institute, 872 Towne Center Drive, Pomona, CA.
Gregory M
GM
Dick
Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN.|Weldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Drive, Lafayette, IN.
Alexander M
AM
Kiel
Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN.
Johnathan D
JD
Tune
D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000033:anatomy & histology / Q000294:innervation; D004730:Endothelium, Vascular / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D006728:Hormones / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
D006728:Hormones; D007473:Ion Channels