A new benzophenone glycoside from the leaves of Mitracarpus villosus.
A new benzophenone glycoside, mitraphenone A (1), together with three known compounds (2-4) were isolated from the leaves of the traditionally used medicinal plant Mitracarpus villosus (Rubiaceae) collected in Nigeria. A combination of one- and two-dimensional NMR spectroscopic and mass spectrometric measurements were carried out to identify the structure of 1. All isolated compounds (1-4) were screened for their antibacterial activity against several Gram-positive and Gram-negative bacteria. Compound 1 exhibited moderate activity against Enterococcus faecium (strains ATCC 35667 and ATCC 700221) and Staphylococcus aureus ATCC 25923 with MIC values ranging from 25 to 50 μM.
a Institute of Pharmaceutical Biology and Biotechnology , Heinrich Heine University , Duesseldorf , Germany.|b Faculty of Pharmaceutical Sciences, Department of Pharmaceutical and Medicinal Chemistry , Nnamadi Azikiwe University , Awka , Nigeria.
Kenneth G
KG
Ngwoke
b Faculty of Pharmaceutical Sciences, Department of Pharmaceutical and Medicinal Chemistry , Nnamadi Azikiwe University , Awka , Nigeria.
Njideka
N
Orame
a Institute of Pharmaceutical Biology and Biotechnology , Heinrich Heine University , Duesseldorf , Germany.
Shuai
S
Liu
b Faculty of Pharmaceutical Sciences, Department of Pharmaceutical and Medicinal Chemistry , Nnamadi Azikiwe University , Awka , Nigeria.
Festus B C
FBC
Okoye
a Institute of Pharmaceutical Biology and Biotechnology , Heinrich Heine University , Duesseldorf , Germany.
Georgios
G
Daletos
a Institute of Pharmaceutical Biology and Biotechnology , Heinrich Heine University , Duesseldorf , Germany.
Peter
P
Proksch
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001577:Benzophenones / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009549:Nigeria; D064209:Phytochemicals / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D001577:Benzophenones; D006027:Glycosides; D064209:Phytochemicals
Mitracarpus villosus; antibacterial activity; benzophenone glycoside; natural products