Antibacterial, antioxidant, antifungal and anti-inflammatory activities of crude extract from Nitraria schoberi fruits.
This study is the first comprehensive investigation of the antibacterial, antioxidant, antifungal and anti-inflammatory activities of a crude extract from Nitraria schoberi L. (Zygophyllaceae) fruits. The extract was tested against four Gram-negative (Pseudomonas aeruginosa, Enterobacter aerogenes, Klebsiella pneumoniae and Acinetobacter lwoffii) and one Gram-positive (Staphylococcus aureus) bacteria using the agar disc diffusion and microdilution methods. P. aeruginosa was inhibited the most (widest inhibition zone) while K. pneumonia showed the largest MIC value. The antioxidant activity of fruits (0.02 mg/mL vs. 0.04, 0.06 and 1.00 mg/mL for α-tocopherol, butylated hydroxyanisole and ascorbic acid, respectively) was determined by the paired diene method. The antifungal activity of N. schoberi fruits was tested against different fungi, including Aspergillus niger and Candida albicans, with 300 µg/mL of fruit extract being the most effective concentration. The percentage of anti-inflammatory activity assayed for N. schoberi fruit extract at 100, 200 and 500 µg/mL was 36.12, 59.89 and 88.33 %, respectively. N. schoberi fruits possess potent antibacterial, antioxidant, antifungal and anti-inflammatory properties, and may be used as an antibacterial and antifungal to treat diseases and/or as a protective agent against disorders associated with oxidative stress and inflammation.
Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran. javad.sharifirad@gmail.com.|Department of Pharmacognosy, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran. javad.sharifirad@gmail.com.
Javad
J
Sharifi-Rad
Pediatric Infections Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. m.hoseinialfatemi@gmail.com.
Seyedeh Mahsan
SM
Hoseini-Alfatemi
Department of Range and Watershed Management, Faculty of Natural Resources, University of Zabol, Zabol, Iran.
Majid
M
Sharifi-Rad
, Miki-cho Post Office Retired, Ikenobe 3011-2, P.O. Box 7, Kagawa-ken, 761-0799, Japan.
Jaime A
JA
Teixeira da Silva
Agar disc diffusion method; Anti-inflammatory activity; Antifungal activity; Antimicrobial activity; Antioxidant activity; Zygophyllaceae