Aspirin and risk of multiple myeloma in adults: A systematic review and meta-analysis.
Multiple myeloma is a relatively uncommon plasma cell malignancy. Preclinical and clinical studies have suggested that aspirin might modify the risk of multiple myeloma. We performed a systematic review and meta-analysis of studies to examine the association between regular aspirin use and risk of multiple myeloma. Five observational studies including 332,660 adults were evaluated. The pooled estimate had a hazard ratio of 0.90 (95% confidence interval =0.58-1.39; P=0.638). Odds ratios from the two case-control studies were similar. The findings demonstrated that there was no significant association between aspirin use and the risk of multiple myeloma.
Department of Clinical Oncology, Tuen Mun Hospital, Tuen Mun, Hong Kong, SAR, China.
Shing Fung
SF
Lee
Department of Clinical Oncology, Tuen Mun Hospital, Tuen Mun, Hong Kong, SAR, China.
Ting Ying
TY
Ng
Department of Clinical Oncology, Tuen Mun Hospital, Tuen Mun, Hong Kong, SAR, China.
Frank Chi Sing
FC
Wong
Department of Clinical Oncology, Tuen Mun Hospital, Tuen Mun, Hong Kong, SAR, China.
Stewart Yuk
SY
Tung
Analgesics; Aspirin; Meta-analysis; Multiple myeloma; Neoplasms