ILC-poiesis: Making Tissue ILCs from Blood.
The development of human innate lymphoid cells (ILCs) remains poorly characterized. In a recent issue of Cell, Lim et al. show that human peripheral-blood CD117+ILCs harbor ILC precursors (ILCPs) derived from hematopoietic stem cells. Peripheral-blood ILCPs can generate all ILC subsets in vivo and in vitro.
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Clinical and Experimental Medicine, Linköping University, 581 83 Linköping, Sweden. Electronic address: jenny.mjosberg@ki.se.
Jenny
J
Mjösberg
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 171 77 Stockholm, Sweden.
Luca
L
Mazzurana
D006412:Hematopoietic Stem Cells; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes