The singular epidemiology of HPV infection among French Guianese women with normal cytology.
BACKGROUND
In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana.


METHODS
Before the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear. Only women with normal cytology and a good quality smear were analyzed. The detection of HPV-DNA was performed using the GREINER-BIO-ONE kit.


RESULTS
Overall, 27.2% of women with normal cervical cytology had a positive HPV-test. There was a U-shaped evolution of prevalence with women over 50 years having the highest HPV prevalence, followed by the 20 to 29 years group. The most prevalent HPV genotypes were HPV 53(3.52%), 68(3.33%), 52(2.59%), 31(2.22%) and 16 (1.85%). The proportion of HPV 16 among HPV-infected women was 6.8%.


CONCLUSIONS
HPV prevalence in cytologically normal women was very high. The most prevalent genotypes were very different from what is usually described in the world, and notably in South America.
Centre d'Investigation Clinique Antilles-Guyane, CIC INSERM 1424, Centre hospitalier de Cayenne, Rue des flamboyants, 97300, Cayenne, French Guiana.
Antoine
A
Adenis
Centre d'Investigation Clinique Antilles-Guyane, CIC INSERM 1424, Centre hospitalier de Cayenne, Rue des flamboyants, 97300, Cayenne, French Guiana.
Valentin
V
Dufit
Centre d'Investigation Clinique Antilles-Guyane, CIC INSERM 1424, Centre hospitalier de Cayenne, Rue des flamboyants, 97300, Cayenne, French Guiana.
Maylis
M
Douine
Laboratoire de Virologie, CHU de la Martinique, Fort de France, Martinique.
Fatiha
F
Najioullah
Laboratoire d'anatomopathologie, CHU de la Martinique, Fort de France, Martinique.
Vincent
V
Molinie
Laboratoire d'anatomopathologie, CHU de la Martinique, Fort de France, Martinique.
Dominique
D
Catherine
Laboratoire de Virologie, CHU de la Martinique, Fort de France, Martinique.
Odile
O
Kilié
Service de Gynecologie Obstétrique, Centre hospitalier de Cayenne, Cayenne, French Guiana.
Nadia
N
Thomas
AGDOC Association de Dépistage Organisé des Cancers de Guyane, Cayenne, French Guiana.
Jean Luc
JL
Deshayes
Département des Centres délocalisés de prévention et de soins, Centre Hospitalier de Cayenne, 97300, Cayenne, French Guiana.
Paul
P
Brousse
Département des Centres délocalisés de prévention et de soins, Centre Hospitalier de Cayenne, 97300, Cayenne, French Guiana.
Hatem Ben
HB
Amor
Département des Centres délocalisés de prévention et de soins, Centre Hospitalier de Cayenne, 97300, Cayenne, French Guiana.
Remy
R
Pignoux
Service de Gynecologie Obstétrique, Centre Hospitalier de l'Ouest Guyanais, Saint Laurent du Maroni, Cayenne, French Guiana.
Gabriel
G
Carles
Département des Centres délocalisés de prévention et de soins, Centre Hospitalier de Cayenne, 97300, Cayenne, French Guiana.
Claire
C
Grenier
Laboratoire des interactions virus Hôtes, Institut Pasteur de la Guyane, Cayenne, French Guiana.
Vincent
V
Lacoste
Laboratoire de Virologie, CHU de la Martinique, Fort de France, Martinique.
Raymond
R
Cesaire
Centre d'Investigation Clinique Antilles-Guyane, CIC INSERM 1424, Centre hospitalier de Cayenne, Rue des flamboyants, 97300, Cayenne, French Guiana. mathieu.nacher@ch-cayenne.fr.
Mathieu
M
Nacher
D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000166:cytology; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005616:French Guiana / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology / Q000517:prevention & control; D015995:Prevalence; D011795:Surveys and Questionnaires; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology / Q000517:prevention & control; D014932:Women's Health Services; D055815:Young Adult
D004279:DNA, Viral
French Guiana; Genotype; Human papillomavirus; Normal cytology; Prevalence