Regulation role of CRTC3 in skeletal muscle and adipose tissue.
The cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway plays important role in regulating energy homeostasis. Many of the effects of the cAMP-PKA signaling is mediated through the cAMP responsive element binding protein (CREB) and its coactivator CREB-regulated transcription coactivators (CRTCs). CRTC3 is a member of CRTCs family proteins and plays important roles in glucose and energy metabolism. Previous studies show that global knockout of CRTC3 enhances oxygen consumption and energy expenditure and subsequently protects the knockout animal against obesity. In skeletal muscle, CRTC3 affects lipid and glycogen metabolism and mitochondrial biogenesis. In white adipocytes, CRTC3 regulates GLUT4 expression and glucose uptake. More recently, the localization and function of CRTC3 in brown fat have been reported. In this review, we mainly discuss the regulatory role of CRTC3 in skeletal muscle and adipose tissues.
College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou, Zhejiang, P. R. China.|Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Hangzhou, Zhejiang, P. R. China.
Jiaqi
J
Liu
College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou, Zhejiang, P. R. China.|Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Hangzhou, Zhejiang, P. R. China.
Ziye
Z
Xu
College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou, Zhejiang, P. R. China.|Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Hangzhou, Zhejiang, P. R. China.
Weiche
W
Wu
College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou, Zhejiang, P. R. China.|Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Hangzhou, Zhejiang, P. R. China.
Yizhen
Y
Wang
College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou, Zhejiang, P. R. China.|Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Hangzhou, Zhejiang, P. R. China.
Tizhong
http://orcid.org/0000-0002-4738-414X
T
Shan
D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
C495791:CRTC3 protein, human; D014157:Transcription Factors; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D055372:AMP-Activated Protein Kinases; D005947:Glucose
CRTC3; adipose tissue; glucose and lipid metabolism; skeletal muscle