The effect of different mitral annuloplasty rings on valve geometry and annular stress distribution†.
To characterize the remodelling effects and deformational forces of normosized rigid, semirigid and flexible mitral annuloplasty rings after implantation in healthy pigs.



Measurements were performed in vivo with 80-kg porcine animals. Twenty-eight animals were randomized into a no ring group, a flexible ring group (Duran AnCore Ring, Medtronic, Minneapolis, MN, USA), a rigid ring group (Carpentier-Edwards Classic annuloplasty ring, Edwards Lifesciences, Irvine, CA, USA) and a semirigid ring group (Carpentier-Edwards Physio I annuloplasty ring, Edwards Lifesciences). Sonomicrometry crystals were implanted together with an annuloplasty ring and a dedicated mitral annular force transducer. The mitral annuloplasty rings were compared with respect to annular geometry and mitral annular forces.



Cyclic changes in the mitral annulus (MA) circumference were significantly lower for all ring groups (flexible: 7 ± 3 mm, semirigid: 4 ± 2 mm and rigid: 2 ± 1 mm) compared to the no ring group (11 ± 5 mm), implying the remodelling capacity of all annuloplasty rings. The cyclic change of the MA area and the septa-lateral and inter-commissural distances were equal in the semirigid and rigid ring groups and significantly lower compared to the no ring and flexible ring groups, suggesting a stronger and equal remodelling effect in the semirigid and rigid ring groups. Forces measured in the transducer reflected the remodelling capacity of the annuloplasty rings and were in general lower for the semirigid and rigid ring groups compared to the no ring and flexible ring groups. Especially the forces in the inter-commissural direction were significantly reduced for the semirigid and rigid ring groups (semi-rigid: 1.4 ± 0.8 N, rigid: 1.2 ± 0.8 N) compared to the no ring and flexible ring groups (no ring: 3.0 ± 1.1 N, flexible: 3.4 ± 1.6 N).



This study is the first to describe different remodelling effects and deformational forces of normosized mitral annuloplasty rings in vivo . Insights into the relationship between the remodelling effects and the accumulated forces of different mitral annuloplasty rings may have implications for ring selections in an aetiology-based mitral valve repair strategy. We propose the application of such a biomechanical approach for quantitative comparison of mitral annuloplasty rings and for future innovations on a rational basis.
Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.|Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Søren Nielsen
SN
Skov
Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.|Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Diana Mathilde
DM
Røpcke
Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.|Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Marcell Juan
MJ
Tjørnild
Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.|Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Christine
C
Ilkjær
Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.|Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Jonas
J
Rasmussen
Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.|Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Hans
H
Nygaard
Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.|Department of Biomedical Engineering, University of Arkansas, Fayetteville, AR, USA.
Morten Olgaard
MO
Jensen
Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.|Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Sten Lyager
SL
Nielsen
D000818:Animals; D004195:Disease Models, Animal; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D008943:Mitral Valve / Q000601:surgery*; D058386:Mitral Valve Annuloplasty / Q000379:methods*; D008944:Mitral Valve Insufficiency / Q000503:physiopathology / Q000601:surgery*; D011474:Prosthesis Design; D013552:Swine
Annuloplasty ring selection; Mitral annular forces; Mitral valve; Mitral valve annuloplasty