The function of myostatin in the regulation of fat mass in mammals.
Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mutation in its coding region can lead to the famous double muscle trait in cattle. Muscle and adipose tissue develop from the same mesenchymal stem cells, and researchers have found that MSTN is expressed in fat tissues and plays a key role in adipogenesis. Interestingly, MSTN can exert a dual function, either inhibiting or promoting adipogenesis, according to the situation. Due to its potential function in controlling body fat mass, MSTN has attracted the interest of researchers. In this review, we explore its function in regulating adipogenesis in mammals, including preadipocytes, multipotent stem cells and fat mass.
Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan, Hubei 430208 People's Republic of China.
Bing
B
Deng
Key Laboratory of Swine Genetics and Breeding of the Agricultural Ministry and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070 People's Republic of China.
Feng
F
Zhang
Wuhan University of Technology, Wuhan, 430074 People's Republic of China.
Jianghui
J
Wen
Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan, Hubei 430208 People's Republic of China.
Shengqiang
S
Ye
Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan, Hubei 430208 People's Republic of China.
Lixia
L
Wang
Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan, Hubei 430208 People's Republic of China.
Yu
Y
Yang
Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Science and Technology, Wuhan, Hubei 430208 People's Republic of China.
Ping
P
Gong
Key Laboratory of Swine Genetics and Breeding of the Agricultural Ministry and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070 People's Republic of China.|The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070 China.
Siwen
S
Jiang
Adipogenesis; Fat; Myostatin; Regulation; Signaling pathway