[The clinical impact of artery-first approach combined with vascular resection and reconstruction in the treatment of pancreatic head carcinoma].
Objective:To evaluate the application of artery first, combined vascular resection and reconstruction in the treatment of pancreatic head carcinoma.Methods:The clinical data of 13 patients with pancreatic head cancer were retrospectively analyzed from February 2014 to March 2016 in the Affiliated Hospital of Xiamen University. Preoperative computed tomography of high resolution layer or magnetic resonance imaging examination demonstrated pancreatic head carcinoma, as well as close adhesion, stenosis, compression or displacement of superior mesenteric vein or portal vein wall. In the operation, the artery first approach was used and the whole arterial blood supply in the head of the pancreas was fully exposed and interdicted. Finally, en block resection and vascular resection and reconstruction was adopted.Results:12 of 13 patients had pancreatoduodenectomy synchronously with vascular resection and reconstruction; the other patient had these two surgery sequentially. Four patients received blood vessel wedge resection, five had segmental resection combined with end to end suture, and four had segmental resection combined with artificial vascular graft reconstruction. Operation time was (327.2±65.5) minutes, and the amount of blood loss was (472.6±226.4) millilitres. One patient suffered from delayed gastric emptying, and two patients had pancreatic fistula. All patients recovered from postoperative complications by conservative treatment. No patients developed biliary fistula, gastrointestinal fistula, abdominal infection, pulmonary infection, diarrhea, hypoglycemia or other complications, and none died in perioperative period. Postoperative pathological findings confirmed the diagnosis of pancreatic ductal adenocarcinoma. Mean tumor diameter was (4.2±1.5)cm, and (3.8±1.5) metastasis were found in (13.6±2.5) resected lymph nodes. In 11 cases, the tumor cells were found in the outer membrane of blood vessels, 2 cases were found to have tumor invasion in the inner membrane, and all the resection margins were negative. All patients were followed up, and 2 patients died of liver metastasis 11 months and 18 months after operation, respectively. One patient survived with local recurrence of tumor 13 months after surgery. Other patients had no tumor recurrence and metastasis.Conclusions:The artery first approch combined vascular resection and reconstruction is safe effective and feasible in the treatment of pancreatic head carcinoma. It can improve the ablation rate of pancreatoduodenectomy.
Department of Hepatobiliary Surgery, Chenggong Hospital Affiliated to Xiamen University, Xiamen Key Laboratory of biliary tract diseases, Xiamen 361000, China.
J L
JL
Huang
Department of Hepatobiliary Surgery, Chenggong Hospital Affiliated to Xiamen University, Xiamen Key Laboratory of biliary tract diseases, Xiamen 361000, China.
W G
WG
Li
Department of Hepatobiliary Surgery, Chenggong Hospital Affiliated to Xiamen University, Xiamen Key Laboratory of biliary tract diseases, Xiamen 361000, China.
F Z
FZ
Chen
Department of Hepatobiliary Surgery, Chenggong Hospital Affiliated to Xiamen University, Xiamen Key Laboratory of biliary tract diseases, Xiamen 361000, China.
Z J
ZJ
Su
Department of Hepatobiliary Surgery, Chenggong Hospital Affiliated to Xiamen University, Xiamen Key Laboratory of biliary tract diseases, Xiamen 361000, China.
F M
FM
Li
Department of Hepatobiliary Surgery, Chenggong Hospital Affiliated to Xiamen University, Xiamen Key Laboratory of biliary tract diseases, Xiamen 361000, China.
B
B
Liu
D001158:Arteries / Q000601:surgery*; D021441:Carcinoma, Pancreatic Ductal / Q000098:blood supply* / Q000473:pathology / Q000601:surgery*; D000072700:Conservative Treatment; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D009364:Neoplasm Recurrence, Local; D061646:Operative Time; D010179:Pancreas / Q000098:blood supply* / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000706:statistics & numerical data; D011169:Portal Vein; D011183:Postoperative Complications / Q000628:therapy; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies
Pancreatic neoplasms; Surgical treatment; Vascular treatment