A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles.
In this paper, highly purified and stable gold nanoparticle (AuNP) dimers connected at the two ends of DNA linkage were prepared by a versatile method. A nanostructured, surface-enhanced Raman scattering (SERS) switching sensor system was fabricated based on the controlled organization of gold nanoparticles (AuNPs) by a DNA nanomachine through the controlled formation/deformation of SERS "hotspots". This strategy not only opens opportunities in the precise engineering of gap distances in gold-gold nanostructures in a highly controllable and reproducible fashion, but also provides a unique ability to research the origin of SERS and sequence-specific DNA detection.
Department of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, China. shanshui4956@126.com.
Yansheng
Y
Li
Department of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, China. cy172872060@163.com.
Yaya
Y
Cheng
Department of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, China. xuliping@ustb.edu.cn.
Liping
L
Xu
Department of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, China. hongwudu@ustb.edu.cn.
Hongwu
H
Du
Peking University People's Hospital, Beijing 100083, China. zhangpeixun@126.com.
Peixun
P
Zhang
Department of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, China. wyq_wen@iccas.ac.cn.
Yongqiang
Y
Wen
Department of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, China. zhangxueji@ustb.edu.cn.
Xueji
X
Zhang
gold nanoparticles; molecular beacon sensors; self-assembly; surface-enhanced Raman scattering (SERS); switch