Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer.
BACKGROUND
A patient's medical history and familial cancer history are important information for assessing the risk of hereditary cancer. We have generated a self-administered questionnaire for patients with gynecologic cancer. This pilot study analyzed the usefulness of this questionnaire and the rates of patients that meet the Society of Gynecologic Oncology criteria in ovarian cancer and endometrial cancer patients.


METHODS
Ovarian or endometrial cancer patients were recruited for this study. After informed consent was obtained, participants completed the questionnaire. Genetic risks were assessed from the data of each patient's questionnaire by Society of Gynecologic Oncology guideline. Clinical and pathological findings were compared between the genetic risk groups.


RESULTS
A total of 105 patients were identified with ovarian cancer and 56 patients with endometrial cancer eligible for this study. According to the Society of Gynecologic Oncology guideline, of the 105 ovarian cancer patients, 25 patients (23%) had a 20-25% risk and three patients (2.9%) had a 5-10% risk of hereditary breast and ovarian cancer syndrome. A further 22 patients (21%) had a 5-10% risk of Lynch syndrome. Two patients (1.9%) met the Amsterdam criteria II. Of 56 endometrial cancer patients, 24 patients (42.9%) had a 5-10% risk of Lynch syndrome. The endometrial cancer patients with genetic risk of Lynch syndrome were younger (mean age: 47.79) at diagnosis compared to patients without a genetic risk of Lynch syndrome (mean age: 57.91).


CONCLUSIONS
In this study, we were able to show that the newly designed questionnaire is a useful tool for evaluating cancer family history along with Society of Gynecologic Oncology criteria or Amsterdam criteria II. When considering the risk of Lynch syndrome for a patient with ovarian cancer, it is important to collect a second and third relative's family history.
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Kenta
K
Masuda
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Akira
A
Hirasawa
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Haruko
H
Irie-Kunitomi
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Tomoko
T
Akahane
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Arisa
A
Ueki
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Yusuke
Y
Kobayashi
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Wataru
W
Yamagami
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Hiroyuki
H
Nomura
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Fumio
F
Kataoka
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Eiichiro
E
Tominaga
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Kouji
K
Banno
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Nobuyuki
N
Susumu
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Daisuke
D
Aoki
D000328:Adult; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005833:Genital Neoplasms, Female / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics; D010375:Pedigree; D010865:Pilot Projects; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires
Lynch syndrome; endometrial cancer; family history; hereditary breast and ovarian cancer syndrome; ovarian cancer; self-administered questionnaire