Mechanisms of resistance to quinolones in Salmonella Typhimurium from patients with infectious diarrhea.
This study investigated the mechanisms of resistance of 36 quinolone-resistant Salmonella Typhimurium strains isolated from outpatients with infectious diarrhea in Beijing Tian Tan Hospital between 2013 and 2015. The resistance spectrum of the 36 strains was measured using a broth dilution method. Class 1 integrons harboring the β-lactamase gene and mutations in quinolone resistance determining regions were also investigated. All 36 quinolone-resistant Salmonella Typhimurium strains were found to be multidrug-resistant and the majority of these strains harbored Class 1 integrons. These findings study suggests that strategies for determining resistance spectrums should be implemented with greater urgency.
Emergency Department, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Jing
J
Yuan
Emergency Department, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Wei
W
Guo
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002681:China; D003967:Diarrhea / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D005798:Genes, Bacterial; D006801:Humans; D032023:Integrons; D008826:Microbial Sensitivity Tests; D010045:Outpatients; D015363:Quinolones / Q000494:pharmacology*; D012480:Salmonella Infections / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D015363:Quinolones
Salmonella Typhimurium; diarrhea; fluoroquinolone; resistance