Hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), maternal smoking and size at birth.
In a sample of 442 births from the Child Health and Development Studies cohort, we examined associations between maternal prenatal exposure to hydroxylated polychlorinated biphenyl metabolites (OH-PCBs) and pregnancy outcomes, and whether associations were mediated by maternal thyroid hormone levels and/or modified by maternal smoking. Compared to nonsmokers, smokers had twice the mean concentration of 4-OH-CB107 (p<0.001) and lower levels of its parent compound, PCB118 (p=0.001). Among mothers who smoked, the birth weight of newborns with maternal concentrations of 4-OH-CB107 in the upper quartile was 316g lighter (95% confidence interval (CI) 566, 65) compared to those with maternal concentrations in the lowest quartile, after control for PCB118 and other potential confounders. This association was not observed for non-smoking mothers and was not mediated by maternal thyroid hormone levels. Maternal prenatal 4-OH-CB107 levels appear to be influenced by maternal smoking and contribute to lower birth weight among smokers.
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Katrina
K
Kezios
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Yiwei
Y
Gu
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Xinhua
X
Liu
Child Health and Development Studies, Public Health Institute, Berkeley, CA 94709, USA.
Piera
P
Cirillo
Department of Toxic Substances Control California Environmental Protection Agency, Berkeley, CA 94710, USA.
Darcy
D
Tarrant
Department of Toxic Substances Control California Environmental Protection Agency, Berkeley, CA 94710, USA.
Myrto
M
Petreas
Department of Toxic Substances Control California Environmental Protection Agency, Berkeley, CA 94710, USA.
Jun-Soo
JS
Park
Child Health and Development Studies, Public Health Institute, Berkeley, CA 94709, USA.
Barbara
B
Cohn
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. Electronic address: prf1@cumc.columbia.edu.
Pam
P
Factor-Litvak
D000293:Adolescent; D001724:Birth Weight; D002648:Child; D002675:Child, Preschool; D052244:Endocrine Disruptors / Q000097:blood* / Q000378:metabolism; D004785:Environmental Pollutants / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008297:Male; D018811:Maternal Exposure; D009035:Mothers; D011078:Polychlorinated Biphenyls / Q000097:blood* / Q000378:metabolism; D011247:Pregnancy; D012907:Smoking / Q000097:blood*; D013963:Thyroid Hormones / Q000097:blood
D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D013963:Thyroid Hormones; D011078:Polychlorinated Biphenyls
Birth outcomes; Birth weight; Gestational length; Hydroxylated PCB metabolites; Maternal smoking; Maternal thyroid hormone; Polychlorinated biphenyls