Neuroprotective effect of Dl-3-n-butylphthalide on patients with radiation-induced brain injury: a clinical retrospective cohort study.
OBJECTIVE
To evaluate the neuroprotective effects of Dl-3-n-butylphthalide (NBP) on patients with radiation-induced brain injury, a hospital-based, clinical retrospective cohort study was conducted.


METHODS
Data were collected on patients diagnosed with radiation-induced brain injury from January 2009 to January 2015 in Department of Neurology, Sun Yat-Sen Memorial Hospital. All patients enrolled have received cranial radiotherapy and were diagnosed with radiation-induced brain injury. Patients fulfilling certain eligibility criteria were recruited for analysis. The clinical therapeutic effects were observed and evaluated by LENT/SOMA scores before and one month after treatment in these two groups, respectively.


RESULTS
The therapeutic effects of headache (total efficiency 75.76%), eurologic deficit (total efficiency 81.58%), cognitive functions (total efficiency 77.78%) and MRI results (total efficiency 74.29%) were better in the experimental group than those in the control group (p < 0.05). Nevertheless, there was no significant difference in mood and personality changes between these two groups.


CONCLUSIONS
Administration of Dl-3-n-butylphthalide, in adjunct to corticosteroid therapy, might provide a better outcome in patients with radiation-induced brain injury.
a Department of Neurology , Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou , China.
Xiaoni
X
Zhang
a Department of Neurology , Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou , China.
Yi
Y
Li
a Department of Neurology , Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou , China.
Xiangpen
X
Li
a Department of Neurology , Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou , China.
Xiaoming
X
Rong
a Department of Neurology , Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou , China.
Yamei
Y
Tang
a Department of Neurology , Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou , China.
Ying
Y
Peng
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D001572:Benzofurans / Q000008:administration & dosage / Q000494:pharmacology*; D001930:Brain Injuries / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D016371:Cranial Irradiation / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017063:Outcome Assessment, Health Care; D011832:Radiation Injuries / Q000188:drug therapy*; D012189:Retrospective Studies
D000305:Adrenal Cortex Hormones; D001572:Benzofurans; D018696:Neuroprotective Agents; C027125:3-n-butylphthalide
Dl-3-n-butylphthalide; Radiation-induced brain injury; clinical study; neurologic function protection; radiotherapy