Simple index of functional connectivity at rest in Multiple Sclerosis fatigue.
To investigate the EEG-derived functional connectivity at rest (FCR) patterns of fatigued Multiple Sclerosis (MS) patients in order to find good parameters for a future EEG-Neurofeedback intervention to reduce their fatigue symptoms.



We evaluated FCR between hemispheric homologous areas, via spectral coherence between pairs of corresponding left and right bipolar derivations, in the Theta, Alpha and Beta bands. We estimated FCR in 18MS patients with different levels of fatigue and minimal clinical severity and in 11 age and gender matched healthy controls. We used correlation analysis to assess the relationship between the fatigue scores and the FCR values differing between fatigued MS patients and controls.



Among FCR values differing between fatigued MS patients and controls, fatigue symptoms increased with higher Beta temporo-parietal FCR (p=0.00004). Also, positive correlations were found between the fatigue levels and the fronto-frontal FCR in Beta and Theta bands (p=0.0002 and p=0.001 respectively).



We propose that a future EEG-Neurofeedback system against MS fatigue would train patients to decrease voluntarily the beta coherence between the homologous temporo-parietal areas.



We extracted a feature for building an EEG-Neurofeedback system against fatigue in MS.
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: korhan.buyukturkoglu@mssm.edu.
Korhan
K
Buyukturkoglu
Laboratory of Electrophysiology for Translational Neuroscience (LET'S)-ISTC, CNR, Rome, Italy; Movement Control and Neuroplasticity Research Group, Department of Kinesiology, KU Leuven, Leuven, Belgium; Department of Information Engineering, Università Politecnica delle Marche, Ancona, Italy.
Camillo
C
Porcaro
Laboratory of Electrophysiology for Translational Neuroscience (LET'S)-ISTC, CNR, Rome, Italy.
Carlo
C
Cottone
Laboratory of Electrophysiology for Translational Neuroscience (LET'S)-ISTC, CNR, Rome, Italy; Institute of Neurology, Catholic University of the Sacred Hearth, Rome, Italy.
Andrea
A
Cancelli
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Matilde
M
Inglese
Laboratory of Electrophysiology for Translational Neuroscience (LET'S)-ISTC, CNR, Rome, Italy.
Franca
F
Tecchio
D000328:Adult; D001611:Beta Rhythm; D016022:Case-Control Studies; D005221:Fatigue / Q000209:etiology / Q000503:physiopathology*; D025461:Feedback, Physiological; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology*; D009434:Neural Pathways; D010296:Parietal Lobe / Q000502:physiology / Q000503:physiopathology; D013702:Temporal Lobe / Q000502:physiology / Q000503:physiopathology
Brain computer interfaces (BCI); Coherence; EEG functional connectivity at rest (FCR); Electroencephalography (EEG); MS fatigue; Multiple Sclerosis; Neurofeedback