Impact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment.
In healthy older adults, resveratrol supplementation has been shown to improve long-term glucose control, resting-state functional connectivity (RSFC) of the hippocampus, and memory function. Here, we aimed to investigate if these beneficial effects extend to individuals at high-risk for dementia, i.e., patients with mild cognitive impairment (MCI). In a randomized, double-blind interventional study, 40 well-characterized patients with MCI (21 females; 50-80 years) completed 26 weeks of resveratrol (200 mg/d;n= 18) or placebo (1,015 mg/d olive oil;n= 22) intake. Serum levels of glucose, glycated hemoglobin A1c and insulin were determined before and after intervention. Moreover, cerebral magnetic resonance imaging (MRI) (3T) (n= 14 vs. 16) was conducted to analyze hippocampus volume, microstructure and RSFC, and neuropsychological testing was conducted to assess learning and memory (primary endpoint) at both time points. In comparison to the control group, resveratrol supplementation resulted in lower glycated hemoglobin A1c concentration with a moderate effect size (ANOVARMp= 0.059, Cohen'sd= 0.66), higher RSFC between right anterior hippocampus and right angular cortex (p< 0.001), and led to a moderate preservation of left anterior hippocampus volume (ANOVARMp= 0.061, Cohen'sd= 0.68). No significant differences in memory performance emerged between groups. This proof-of-concept study indicates for the first-time that resveratrol intake may reduce glycated hemoglobin A1c, preserves hippocampus volume, and improves hippocampus RSFC in at-risk patients for dementia. Larger trials with longer intervention time should now determine if these benefits can be validated and extended to cognitive function.
Department of Neurology, Charité - University Medicine BerlinBerlin, Germany; NeuroCure Cluster of Excellence, Charité - University Medicine BerlinBerlin, Germany.
Theresa
T
Köbe
Department of Neurology, Charité - University Medicine BerlinBerlin, Germany; NeuroCure Cluster of Excellence, Charité - University Medicine BerlinBerlin, Germany; Department of Neurology, Max Planck Institute of Human Cognitive and Brain SciencesLeipzig, Germany; SFB 1052 Obesity Mechanism Subproject A1, University of LeipzigLeipzig, Germany.
A Veronica
AV
Witte
Department of Neurology, Charité - University Medicine BerlinBerlin, Germany; NeuroCure Cluster of Excellence, Charité - University Medicine BerlinBerlin, Germany.
Ariane
A
Schnelle
Department of General Medicine, Goethe-University Frankfurt am Main, Germany.
Valentina A
VA
Tesky
Department of General Medicine, Goethe-University Frankfurt am Main, Germany.
Johannes
J
Pantel
Department of Nutrition Physiology and Human Nutrition, Gottfried Wilhelm Leibniz University Hannover, Germany.
Jan-Philipp
JP
Schuchardt
Department of Nutrition Physiology and Human Nutrition, Gottfried Wilhelm Leibniz University Hannover, Germany.
Andreas
A
Hahn
Medical Practice Bohlken for Neurology and Psychiatry Berlin, Germany.
Jens
J
Bohlken
Biostatistics and Clinical Epidemiology, Charité - University Medicine Berlin Berlin, Germany.
Ulrike
U
Grittner
Department of Neurology, Charité - University Medicine BerlinBerlin, Germany; NeuroCure Cluster of Excellence, Charité - University Medicine BerlinBerlin, Germany; Center for Stroke Research Berlin, Charité - University Medicine BerlinBerlin, Germany; Department of Neurology, University Medicine GreifswaldGreifswald, Germany.
Agnes
A
Flöel
MCI; hippocampus; memory performance; resting-state functional connectivity; resveratrol