Effect of age and gender on serum periostin: Relationship to cortical measures, bone turnover and hormones.
Periostin is an extracellular matrix protein, and in bone is expressed most highly in the periosteum. It increases bone formation through osteoblast differentiation, cell adhesion, Wnt signalling and collagen cross-linking. We hypothesised that serum periostin would be high at times of life when cortical modeling is active, in early adulthood and in older age, and that it would correlate with cortical bone measures, bone turnover and hormones that regulate cortical modeling. We conducted a cross-sectional observational study of 166 healthy men and women at three skeletal stages; the end of longitudinal growth (16-18years), peak bone mass (30-32years) and older age (over 70years). We measured serum periostin with a new ELISA optimised for human serum and plasma which recognises all known splice variants (Biomedica). We measured the distal radius and distal tibia with HR-pQCT, and measured serum PINP, CTX, sclerostin, PTH, IGF-1, estradiol and testosterone. Periostin was higher at age 16-18 than age 30-32 (1253 vs 842pmol/l, p<0.001), but not different between age 30-32 and over age 70. Periostin was inversely correlated with tibia cortical thickness and density (R -0.229, -0.233, both p=0.003). It was positively correlated with PINP (R 0.529, p<0.001), CTX (R 0.427, p<0.001) and IGF-1 (R 0.440, p<0.001). When assessed within each age group these correlations were only significant at age 16-18, except for PINP which was also significant over age 70. We conclude that periostin may have a role in IGF-1 driven cortical modeling and consolidation in young adults, but it may not be an important mediator in older adults.
Mellanby Centre for Bone Research, University of Sheffield, UK. Electronic address: j.walsh@sheffield.ac.uk.
Jennifer S
JS
Walsh
Mellanby Centre for Bone Research, University of Sheffield, UK.
Fatma
F
Gossiel
Mellanby Centre for Bone Research, University of Sheffield, UK.
Jessica R
JR
Scott
Mellanby Centre for Bone Research, University of Sheffield, UK.
Margaret A
MA
Paggiosi
Mellanby Centre for Bone Research, University of Sheffield, UK.
Richard
R
Eastell
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015519:Bone Density / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000097:blood*; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood; D012737:Sex Factors; D013739:Testosterone / Q000097:blood; D055815:Young Adult
D015815:Cell Adhesion Molecules; C583557:IGF1 protein, human; C512835:POSTN protein, human; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D011347:Procollagen; C047202:procollagen Type I N-terminal peptide; D013739:Testosterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I
Aging; Bone turnover; Cortex; HR-pQCT; Peak bone mass; Periostin