A positive family history of hypertension might be associated with an accelerated onset of type 2 diabetes: Results from the National Center Diabetes Database (NCDD-02).
Type 2 diabetes, which is characterized by a combination of decreased insulin secretion and decreased insulin sensitivity, can be delayed or prevented by healthy lifestyle behaviors. Therefore, it is important that the population in general understands their personal risk at an early age to reduce their chances of ever developing the disease. A family history of hypertension is known to be associated with insulin resistance, but the effect of a family history of hypertension on the onset of type 2 diabetes has not well been examined. We performed a retrospective study examining patient age at the time of the diagnosis of type 2 diabetes by analyzing a dataset of 1,299 patients (1,021 men and 278 women) who had been diagnosed as having type 2 diabetes during a health checkup. The mean ± standard deviation of the patient age at the time of the diagnosis of diabetes was 49.1 ± 10.4 years for patients with a family history of hypertension and 51.8 ± 11.4 years for patients without a family history of hypertension (p < 0.001). A multivariate linear regression analysis showed a significant association between a family history of hypertension and a younger age at the time of the diagnosis of type 2 diabetes, independent of a family history of diabetes mellitus and a male sex, suggesting that a positive family history of hypertension might be associated with the accelerated onset of type 2 diabetes.
Department of Diabetes Research and Diabetes and Metabolism Information Center, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.|Health Management Center, Toranomon Hospital, Tokyo, Japan.|Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Ritsuko
R
Yamamoto-Honda
Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine Center Hospital, Tokyo, Japan.|Division of Diabetes and Metabolism, Iwate Medical University, Morioka, Japan.
Yoshihiko
Y
Takahashi
Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Yasumichi
Y
Mori
Department of Diabetes and Endocrinology, JR Tokyo General Hospital, Tokyo, Japan.|Division of Diabetes and Endocrinology, Department of Internal Medicine, Tokyo Yamate Medical Center, Japan Community Health care Organization, Tokyo, Japan.
Shigeo
S
Yamashita
Department of Diabetes, the Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan.
Yoko
Y
Yoshida
Department of Diabetes, the Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan.
Shoji
S
Kawazu
Department of Diabetes, the Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan.
Yasuhiko
Y
Iwamoto
Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine Center Hospital, Tokyo, Japan.
Hiroshi
H
Kajio
Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, Japan.
Hidekatsu
H
Yanai
Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, Japan.
Shuichi
S
Mishima
Nagara Medical Center, National Hospital Organization, Gifu, Japan.
Nobuhiro
N
Handa
Yutenji Medical Clinic, Tokyo, Japan.
Kotaro
K
Shimokawa
Kanamachi Yoshida Clinic, Tokyo, Japan.
Akiko
A
Yoshida
National Hospital Organization, Tokyo, Japan.
Hiroki
H
Watanabe
Department of Medical Informatics and Economics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kazuhiko
K
Ohe
Ohta Nishinouchi Hospital, Fukushima, Japan.
Takuro
T
Shimbo
Department of Diabetes Research and Diabetes and Metabolism Information Center, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.|Department of Endocrinology and Diabetes, Saitama Medical University, Saitama, Japan.
Mitsuhiko
M
Noda
D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D015897:Comorbidity; D016208:Databases, Factual; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000235:genetics; D015994:Incidence; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D057566:Self Report
Age at the onset of diabetes; Family history of hypertension; Type 2 diabetes