Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis.
Liver cirrhosis is the outcome of chronic liver injury. The current study aimed to investigate the therapeutic effect of undifferentiated mesenchymal stem cells versusin vitropartially differentiated mesenchymal stem cells on liver cirrhosis and hepatic encephalopathy. 50 adult male albino rats constituted the animal model and were divided into the following groups: control, thioacetamide, undifferentiated mesenchymal stem cells and hepatocyte growth factor-differentiated mesenchymal stem cells groups. Cognitive assessment was achieved by open field test and Y-maze task. We measured serum alanine aminotransferase, albumin and transforming growth factor-beta1, gene expression of α-smooth muscle actin, matrix metalloprotein-2, its tissue inhibitor and apoptotic markers: Bax and Bcl2, brain glial fibrillary acidic protein, synaptophysin, and dopaminergic receptors.
Department of Medical Physiology, Kasr Al Ainy Faculty of Medicine, Cairo University, Egypt.
Dalia Azmy
DA
Elberry
Department of Medical Physiology, Kasr Al Ainy Faculty of Medicine, Cairo University, Egypt.
Shaimaa Nasr
SN
Amin
Department of Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Reham Shehab El Nemr
RS
Esmail
Department of Biochemistry, Kasr Al Ainy Faculty of Medicine, Cairo University, Egypt.
Laila Ahmed
LA
Rashed
Department of Medical Physiology, Kasr Al Ainy Faculty of Medicine, Cairo University, Egypt.
Maha Mohamed
MM
Gamal
basal ganglia; hepatic encephalopathy; hippocampus; liver; stem cells