TOX and ADIPOQ Gene Polymorphisms Are Associated with Antipsychotic-Induced Weight Gain in Han Chinese.
To find the genetic markers related to the antipsychotic-induced weight gain (AIWG), we analyzed associations among candidate gene single-nucleotide polymorphisms (SNPs) and quantitative traits of weight changes and lipid profiles in a Chinese Han population. A total of 339 schizophrenic patients, including 86 first-episode patients (FEPs), meeting the entry criteria were collected. All patients received atypical antipsychotic drug monotherapy and hospitalization and were followed for 12 weeks. Forty-three SNPs in 23 candidate genes were calculated for quantitative genetic association with AIWG, performed by PLINK. The TOX gene SNP rs11777927 (P = 0.009) and the ADIPOQ gene SNP rs182052 (P = 0.019) were associated with AIWG (in body mass index, BMI). In addition, the BDNF SNP rs6265 (P = 0.002), BDAF SNP rs11030104 SNP (P = 0.001), and ADIPOQ SNPs rs822396 (P = 0.003) were significantly associated with the change of waist-to-hip ratio (WHR) induced by atypical antipsychotics. These results were still significant after age and gender adjustments. These findings provide preliminary evidence supporting the role of TOX, ADIPOQ and BDNF in weight and WHR gain induced by atypical antipsychotics.
Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.|Department of Psychiatry, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Shen
S
Li
Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.|Tianjin Mental Health Centre, Tianjin Anding Hospital, Tianjin, 300222, China.
Chengai
C
Xu
Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Yuan
Y
Tian
Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.|Tianjin Mental Health Centre, Tianjin Anding Hospital, Tianjin, 300222, China.
Xueshi
X
Wang
Tianjin Mental Health Centre, Tianjin Anding Hospital, Tianjin, 300222, China.
Rui
R
Jiang
Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Miaomiao
M
Zhang
Tianjin Mental Health Centre, Tianjin Anding Hospital, Tianjin, 300222, China.
Lili
L
Wang
Tianjin Jianhua Hospital, Tianjin, 300112, China.
Guifu
G
Yang
Tianjin Mental Health Centre, Tianjin Anding Hospital, Tianjin, 300222, China.
Ying
Y
Gao
Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Chenyu
C
Song
Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Yukun
Y
He
Tianjin Mental Health Centre, Tianjin Anding Hospital, Tianjin, 300222, China.
Ying
Y
Zhang
Tianjin Mental Health Centre, Tianjin Anding Hospital, Tianjin, 300222, China.
Jie
J
Li
Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Wei-Dong
WD
Li
D052242:Adiponectin / Q000235:genetics*; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D002681:China; D005260:Female; D006609:High Mobility Group Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000188:drug therapy; D049629:Waist-Hip Ratio; D015430:Weight Gain / Q000187:drug effects / Q000235:genetics*
C499918:ADIPOQ protein, human; D052242:Adiponectin; D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; D006609:High Mobility Group Proteins; C558851:TOX protein, human; C579455:BDNF protein, human