Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review.
Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and threonine through interorgan metabolism in which kidneys and liver are the primarily involved. Generally in common feeding conditions, glycine is not sufficiently synthesized in humans, animals, and birds. Glycine acts as precursor for several key metabolites of low molecular weight such as creatine, glutathione, haem, purines, and porphyrins. Glycine is very effective in improving the health and supports the growth and well-being of humans and animals. There are overwhelming reports supporting the role of supplementary glycine in prevention of many diseases and disorders including cancer. Dietary supplementation of proper dose of glycine is effectual in treating metabolic disorders in patients with cardiovascular diseases, several inflammatory diseases, obesity, cancers, and diabetes. Glycine also has the property to enhance the quality of sleep and neurological functions. In this review we will focus on the metabolism of glycine in humans and animals and the recent findings and advances about the beneficial effects and protection of glycine in different disease states.
Department of Biochemistry, Rayalaseema University, Kurnool 518002, India.
Meerza Abdul
MA
Razak
Department of Zoology, K.V.R. Govt College for Women, Kurnool 518002, India.
Pathan Shajahan
PS
Begum
Department of Bionanotechnology, Gachon University, San 65, Bokjeong Dong, Sujeong Gu, Seongnam Si, Gyeonggi Do 461 701, Republic of Korea.
Buddolla
0000-0002-9163-103X
B
Viswanath
Department of Biochemistry, Rayalaseema University, Kurnool 518002, India.
Senthilkumar
0000-0002-8404-8209
S
Rajagopal
D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002794:Choline / Q000378:metabolism; D019587:Dietary Supplements; D005998:Glycine / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008659:Metabolic Diseases / Q000188:drug therapy
D002794:Choline; D005998:Glycine