The Molecular and Morphologic Structures That Make Saltatory Conduction Possible in Peripheral Nerve.
Saltatory conduction is the process by which action potentials are rapidly and efficiently propagated along myelinated axons. In the peripheral nervous system, saltatory conduction is made possible by a series of morphologically and molecularly distinct subdomains in both axons and their associated myelinating Schwann cells. This review briefly summarizes current knowledge on the molecular structure and physiology of the node of Ranvier and adjacent regions of the axoglial unit in peripheral nerve.
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Steven L
SL
Carroll
D000818:Animals; D001369:Axons / Q000502:physiology; D006801:Humans; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology*; D009474:Neurons / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure*; D010525:Peripheral Nerves / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure*; D012583:Schwann Cells / Q000502:physiology / Q000648:ultrastructure
Axon; Ion channels; Node of Ranvier; Peripheral nerve; Saltatory conduction; Schwann cell