Antiviral Drug-Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016.
In February 2016, three influenza B/Victoria/2/87 lineage viruses exhibiting 4- to 158-fold reduced inhibition by neuraminidase inhibitors were detected in Laos. These viruses had an H134N substitution in the neuraminidase and replicated efficiently in vitro and in ferrets. Current antiviral drugs may be ineffective in controlling infections caused by viruses harboring this mutation.
Tatiana
T
Baranovich
Phengta
P
Vongphrachanh
Pakapak
P
Ketmayoon
Thongchanh
T
Sisouk
Khampheng
K
Chomlasack
Viengphone
V
Khanthamaly
Ha Thuy
HT
Nguyen
Vasiliy P
VP
Mishin
Henju
H
Marjuki
John R
JR
Barnes
Rebecca J
RJ
Garten
James
J
Stevens
David E
DE
Wentworth
Larisa V
LV
Gubareva
D000293:Adolescent; D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D000998:Antiviral Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015967:Gene Expression Regulation, Viral; D006801:Humans; D007223:Infant; D009981:Influenza B virus / Q000187:drug effects* / Q000235:genetics; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology*; D007812:Laos / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009439:Neuraminidase / Q000235:genetics*; D055815:Young Adult
D000998:Antiviral Agents; D009439:Neuraminidase
H134N substitution; Laos; antimicrobial resistance; antiviral drug–resistant; influenza; influenza B viruses; mutation; neuraminidase; viruses