Moraxella Species as Potential Sources of MCR-Like Polymyxin Resistance Determinants.
Plasmid-mediated resistance to polymyxins mediated by the MCR-1/2 determinants has been reported inEnterobacteriaceaeworldwide. Using PCR-based and cloning strategies, a series ofMoraxellaspp. were screened formcr-like genes.Moraxellaspp. that are mainly animal pathogens but may also be human pathogens were identified as potential reservoirs ofmcr-like genes.
Emerging Antibiotic Resistance, Medical and Molecular Microbiology Unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland.|INSERM European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland.
Nicolas
N
Kieffer
Emerging Antibiotic Resistance, Medical and Molecular Microbiology Unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland.|INSERM European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland.|Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), Fribourg, Switzerland.|Insitute for Microbiology, University of Lausanne and University Hospital Centre, Lausanne, Switzerland.
Patrice
P
Nordmann
Emerging Antibiotic Resistance, Medical and Molecular Microbiology Unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland laurent.poirel@unifr.ch.|INSERM European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland.|Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), Fribourg, Switzerland.
Laurent
L
Poirel
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004982:Ethanolaminephosphotransferase / Q000235:genetics*; D009016:Moraxella / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D045828:Moraxellaceae Infections / Q000188:drug therapy* / Q000382:microbiology; D010957:Plasmids / Q000235:genetics; D011113:Polymyxins / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D011113:Polymyxins; D004982:Ethanolaminephosphotransferase
MCR; animal; plasmid; polymyxin; reservoir; resistance