Developmental Venous Anomalies Mimicking Neoplasm on 11C-Methionine PET and DSC Perfusion MRI.
Elevated relative cerebral blood volume on perfusion MRI and increased uptake on C-methionine PET can be used to diagnose and guide biopsy of brain tumors but are not specific. We report increased uptake on C-methionine PET associated with 4 developmental venous anomalies (DVAs) in 3 children with brain tumors, which could potentially mimic tumor and misdirect biopsy. Because DVAs are not readily visible on CT, prevention of misdirected biopsy in patients with focally elevated C-methionine uptake and relative cerebral blood volume relies on close correlation with contrast-enhanced anatomic MRI to exclude DVA or other nonneoplastic etiology.
From the Department of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN.
Julie H
JH
Harreld
Mikhail
M
Doubrovin
Elizabeth R
ER
Butch
Angela
A
Edwards
Barry
B
Shulkin
D001921:Brain / Q000000981:diagnostic imaging; D001932:Brain Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging*; D002550:Cerebral Veins / Q000002:abnormalities* / Q000000981:diagnostic imaging; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008715:Methionine; D008875:Middle Aged; D010477:Perfusion; D049268:Positron-Emission Tomography
D008715:Methionine