Dicarboxylic acids as pH sensors for hyperpolarized13C magnetic resonance spectroscopic imaging.
Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.
UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA.
D E
DE
Korenchan
C
C
Taglang
C
C
von Morze
J E
JE
Blecha
J W
JW
Gordon
R
R
Sriram
P E Z
PEZ
Larson
D B
DB
Vigneron
H F
HF
VanBrocklin
J
J
Kurhanewicz
D M
DM
Wilson
R R
RR
Flavell
D002247:Carbon Isotopes / Q000737:chemistry*; D003998:Dicarboxylic Acids / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D019047:Phantoms, Imaging
D002247:Carbon Isotopes; D003998:Dicarboxylic Acids; C000615229:Carbon-13