A phosphine mediated sequential annulation process of 2-tosylaminochalcones with MBH carbonates to construct functionalized aza-benzobicyclo[4.3.0] derivatives.
A novel phosphine mediated sequential annulation process to construct functionalized aza-benzobicyclo[4.3.0] derivatives has been developed involving a one-pot sequential catalytic and stoichiometric process, which generates a series of benzobicyclo[4.3.0] compounds containing one quaternary center with up to 94% yield and 20 : 1 dr value. In this reaction, MBH carbonates act as 1,2,3-C3synthons.
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China. hyou@nankai.edu.cn.
Qinglong
http://orcid.org/0000-0001-8876-8118
Q
Zhang
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China. hyou@nankai.edu.cn.
Yannan
http://orcid.org/0000-0003-4279-4876
Y
Zhu
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China. hyou@nankai.edu.cn.
Hongxing
http://orcid.org/0000-0001-6024-3600
H
Jin
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China. hyou@nankai.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China and Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
You
http://orcid.org/0000-0002-9430-4034
Y
Huang