PRISMA-combined Myeloperoxidase -463G/A gene polymorphism and coronary artery disease: A meta-analysis of 4744 subjects.
BACKGROUND
Myeloperoxidase (MPO) -463G/A gene polymorphism may be associated with an increased risk of developing coronary artery disease (CAD). Studies on the subject, however, do not provide a clear consensus. This meta-analysis was performed to explore the relationship between MPO gene -463G/A polymorphism and CAD risk.


METHODS
This meta-analysis combines data from 4744 subjects from 9 independent studies. By using fixed or random effect models, the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were assessed.


RESULTS
Our analysis found a significant association between MPO gene -463G/A polymorphism and CAD in the whole population under all genetic models: allelic (OR: 0.68, 95% CI: 0.54-0.85, P = 0.0009), recessive (OR: 0.41, 95% CI: 0.22-0.76, P = 0.005), dominant (OR: 0.682, 95% CI: 0.534-0.871, P = 0.002), homozygous (OR: 0.36, 95% CI: 0.16-0.79, P = 0.01), heterozygous genetic model (OR: 0.832, 95% CI: 0.733-0.945, P = 0.004), and additive (OR: 0.64, 95% CI: 0.46-0.90, P = 0.01), especially in the Chinese subgroup (P < 0.05). On the contrary, we found no such relationship in the non-Chinese subgroup (P > 0.05).


CONCLUSIONS
The MPO gene -463G/A polymorphism is associated with CAD risk, especially within the Chinese population. The A allele of MPO gene -463G/A polymorphism might protect the people from suffering the CAD risk.
Department of Geriatrics Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Physiology, University of Cincinnati, Cincinnati, OH Department of Nephrology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yan-Yan
YY
Li
Hui
H
Wang
Jin
J
Qian
Hyun Jun
HJ
Kim
Jing-Jing
JJ
Wu
Lian-Sheng
LS
Wang
Chuan-Wei
CW
Zhou
Zhi-Jian
ZJ
Yang
Xin-Zheng
XZ
Lu
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D003324:Coronary Artery Disease / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D009195:Peroxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D009195:Peroxidase