A Novel Hybrid Plasmid Carrying Multiple Antimicrobial Resistance and Virulence Genes in Salmonella enterica Serovar Dublin.
Virulence plasmids and antibiotic resistance plasmids are usually maintained separately inSalmonellaspp.; however, we report an instance of a hybrid plasmid (pN13-01125) inSalmonella entericaserovar Dublin. Review of the complete sequence of the 172,265-bp plasmid suggests that pN13-01125 is comprised of the previously described pSDVr and pSH696_135 plasmids and that the mechanism of hybridization likely involves IS6(IS26) insertion sequence elements. The plasmid has a low conjugation frequency, confers resistance to six classes of antimicrobials, and contains a completespvvirulence operon.
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Chand S
CS
Mangat
Laboratoire de santé publique du Québec, Saint-Anne-de-Bellevue, Quebec, Canada.
Sadjia
S
Bekal
Center for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, Canada.
Rebecca J
RJ
Irwin
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada michael.mulvey@phac-aspc.gc.ca.
Michael R
MR
Mulvey
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D010957:Plasmids / Q000235:genetics*; D019779:Salmonella enterica / Q000187:drug effects / Q000235:genetics*; D014774:Virulence / Q000235:genetics
D000900:Anti-Bacterial Agents
Salmonella; antimicrobial activity; plasmids; virulence