RETINAL DETACHMENT AND RETROBULBAR CYSTS IN A LARGE COHORT OF OPTIC NERVE COLOBOMA.
OBJECTIVE
To examine the relationship between retinal detachment and retrobulbar cysts in patients with optic nerve coloboma (ONC) and Morning Glory syndrome (MGS).


METHODS
Patients diagnosed with either ONC or MGS were identified through a search of the Sick Kids database. Seventy-one patients either agreed to come in for a B-scan or had an incidental orbital B-scan or magnetic resonance imaging or both. Eyes with orbital B-scan ultrasound and/or magnetic resonance imaging images were assessed independently by two ophthalmologists and a radiologist for the presence of retrobulbar cysts. Retinal detachment was identified clinically with either indirect ophthalmoscopy or from fundus photographs.


RESULTS
Forty-five of 71 (63%) and 26/71 (37%) patients had ONC and MGS, respectively. Retinal detachment occurred significantly more often in eyes with MGS than with ONC (9/17 [53%] vs. 5/45 [11%], P = 0.03, respectively). Retrobulbar cysts were not detected more often in MGS than in ONC (11/45 [24%] vs. 7/26 [27%]; P = 1.0). Eyes with retrobulbar cysts were significantly more likely to be associated with retinal detachment than those without (7/18 [39%] vs. 7/53 [13%]; P = 0.04).


CONCLUSIONS
Retinal detachment occurs more frequently in MGS than in ONC in a cohort of patients referred to a specialist children's retinal service. Eyes with retrobulbar cysts are more likely to be associated with retinal detachment.
Department of Ophthalmology, University of Ottawa, Ottawa, Ontario, Canada.
Yufeng N
YN
Chen
Department of Ophthalmology, Oxford University, Oxford Eye Hospital, Headington, Oxford, United Kingdom.
C K
CK
Patel
Department of Ophthalmology and Vision Sciences, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.
Peter J
PJ
Kertes
Department of Ophthalmology and Vision Sciences, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.
Robert G
RG
Devenyi
Department of Medical Imaging, Division of Neuroradiology.
Susan
S
Blaser
Department of Ophthalmology and Vision Sciences, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.
Wai-Ching
WC
Lam
D002675:Child, Preschool; D003103:Coloboma / Q000150:complications*; D003560:Cysts / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D009898:Optic Disk / Q000002:abnormalities*; D009900:Optic Nerve / Q000002:abnormalities*; D009901:Optic Nerve Diseases / Q000150:complications* / Q000453:epidemiology; D009916:Orbital Diseases / Q000453:epidemiology / Q000209:etiology*; D012163:Retinal Detachment / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors