Gene-based genome-wide association study identified 19p13.3 for lean body mass.
Lean body mass (LBM) is a complex trait for human health. To identify genomic loci underlying LBM, we performed a gene-based genome-wide association study of lean mass index (LMI) in 1000 unrelated Caucasian subjects, and replicated in 2283 unrelated Caucasians subjects. Gene-based association analyses highlighted the significant associations of three genes UQCR, TCF3 and MBD3 in one single locus 19p13.3 (discovery p = 6.10 × 10-5, 1.65 × 10-4and 1.10 × 10-4; replication p = 2.21 × 10-3, 1.84 × 10-3and 6.95 × 10-3; combined p = 2.26 × 10-6, 4.86 × 10-6and 1.15 × 10-5, respectively). These results, together with the known functional relevance of the three genes to LMI, suggested that the 19p13.3 region containing UQCR, TCF3 and MBD3 genes was a novel locus underlying lean mass variation.
Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, PR China.
Shu
S
Ran
Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Jiangsu, PR China.
Lei
L
Zhang
Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Jiangsu, PR China.
Lu
L
Liu
Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Jiangsu, PR China.
An-Ping
AP
Feng
Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Jiangsu, PR China.|Department of Epidemiology and Statistics, School of Public Health, Soochow University, Jiangsu, PR China.
Yu-Fang
YF
Pei
Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, PR China.
Lei
L
Zhang
Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, PR China.
Ying-Ying
YY
Han
Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, PR China.
Yong
Y
Lin
Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Jiangsu, PR China.
Xiao
X
Li
Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Jiangsu, PR China.
Wei-Wen
WW
Kong
Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Jiangsu, PR China.
Xin-Yi
XY
You
Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Jiangsu, PR China.
Wen
W
Zhao
Department of Biostatistics, Tulane University, New Orleans, Louisiana, USA.
Qing
Q
Tian
Department of Biostatistics, Tulane University, New Orleans, Louisiana, USA.
Hui
H
Shen
Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Jiangsu, PR China.|Department of Epidemiology and Statistics, School of Public Health, Soochow University, Jiangsu, PR China.
Yong-Hong
YH
Zhang
Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, PR China.|Department of Biostatistics, Tulane University, New Orleans, Louisiana, USA.
Hong-Wen
HW
Deng
D000328:Adult; D000368:Aged; D001823:Body Composition / Q000235:genetics*; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D013851:Thinness / Q000235:genetics*