Early Huntington's Disease: Impulse Control Deficits but Correct Judgment Regarding Risky Situations.
Huntington's disease (HD) patients show alterations in decision making tasks. However, it is still uncertain if these deficits are due to poor judgment regarding risky situations, or to impulse control deficits.



To elucidate whether decision-making in patients is related to genuine risk behavior or to impulse control deficits.



To test between these two alternative possibilities, we evaluated the performance of 19 prodromal HD patients and 19 matched healthy controls in the Cambridge Gambling Task (CGT). This task assesses decision-making while dissociating between genuine risk-taking behaviors (ascending condition) from impulsive behavior (descending condition).



The results showed that patients and controls had the same performance during all trials in the ascending condition, reflecting a correct judgment regarding risky situations; however, during the descending condition, patients responded before the controls in all trials, making a significantly larger number of higher bets. Unlike the control group, they did not wait for more optimal subsequent options.



These results suggest impulse control deficits in HD gene carriers, but unimpaired risk-taking judgment.
Instituto de Neuroetología, Universidad Veracruzana, México, USA.|Unidad Periférica de Neurociencias, Facultad de Medicina, Universidad Nacional Autónoma de México, Instituto Nacional de Neurología y Neurocirugía "MVS", México, USA.
Victor
V
Galvez
Instituto de Neuroetología, Universidad Veracruzana, México, USA.|Laboratorio de Neuropsicología, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, USA.|Facultad de Psicología, Universidad Veracruzana, México, USA.
Juan
J
Fernandez-Ruiz
Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suarez", México, USA.
Leo
L
Bayliss
Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurología y Neurocirugía, "Manuel Velasco Suarez", México, USA.
Adriana
A
Ochoa-Morales
Consejo Nacional de Ciencia y Tecnología - Cátedras - Instituto de Neuroetología, Universidad Veracruzana, México, USA.
Carlos R
CR
Hernandez-Castillo
Laboratorio de Neuropsicología, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, USA.
Rosalinda
R
Díaz
Unidad Periférica de Neurociencias, Facultad de Medicina, Universidad Nacional Autónoma de México, Instituto Nacional de Neurología y Neurocirugía "MVS", México, USA.
Aurelio
A
Campos-Romo
D000328:Adult; D000368:Aged; D003657:Decision Making; D056344:Executive Function; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000523:psychology*; D007175:Impulsive Behavior; D007600:Judgment; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D062706:Prodromal Symptoms; D011581:Psychological Tests; D011930:Reaction Time; D012309:Risk-Taking
Huntington Disease; decision making; impulse control; judgment; risk-taking