Synthesis and characterization of a novel cationic hydrogel base on salecan-g-PMAPTAC.
Salecan is a biological macromolecular and biocompatible polysaccharide that has been investigated for recent years. Herein, we report a novel cationic hydrogel fabricated by graft-polymerizing 3-(methacryloylamino)propyl-trimethylammonium chloride (MAPTAC) onto salecan chains. The obtained hydrogels were transparent, solid-elastic, macro-porous, ion-sensitive, and non-cytotoxic. The swelling ratios increased with salecan content, while mechanical strength does the opposite. Moreover, drug delivery test was studied as a potential application. Diclofenac sodium (DS) and insulin were selected as model drugs. Interestingly, in drug loading process, DS molecules exhibited highly affinity to these cationic hydrogels. Almost all the DS molecules in loading solution were absorbed and spread into the hydrogel. For drug release profiles, insulin-loaded hydrogel showed an initial rapid release and a sustained release. As a comparison, DS-loaded hydrogel exhibited a more sustained release profile. Results suggested salecan-g-PMAPTAC hydrogel could be a good candidate for anionic drug loading and delivery.
Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing 210094, China.
Wei
W
Wei
Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing 210094, China.
Xiaoliang
X
Qi
Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing 210094, China.
Junjian
J
Li
Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing 210094, China.
Yin
Y
Zhong
Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing 210094, China.
Gancheng
G
Zuo
Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing 210094, China.
Xihao
X
Pan
Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing 210094, China.
Ting
T
Su
Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing 210094, China.
Jianfa
J
Zhang
Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing 210094, China. Electronic address: weidong@njust.edu.cn.
Wei
W
Dong
D060326:Chemistry Techniques, Synthetic; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry* / Q000633:toxicity; D065546:Drug Liberation; D057809:HEK293 Cells; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D058105:Polymerization; D012212:Rheology; D047071:beta-Glucans / Q000138:chemical synthesis* / Q000737:chemistry* / Q000633:toxicity
D004337:Drug Carriers; D047071:beta-Glucans; C577623:salecan; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
Biomaterials; Drug delivery; Hydrogel; Quaternary ammonium salt; Salecan