Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties.
Electrospun micro- and nanofibrous poly(glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) substrates have been extensively used as scaffolds for engineered tissues due to their desirable mechanical properties and their tunable degradability. In this study, we fabricated micro/nanofibrous scaffolds from a PGS-PCL composite using a standard electrospinning approach and then coated them with silver (Ag) using a custom radio frequency (RF) sputtering method. The Ag coating formed an electrically conductive layer around the fibers and decreased the pore size. The thickness of the Ag coating could be controlled, thereby tailoring the conductivity of the substrate. The flexible, stretchable patches formed excellent conformal contact with surrounding tissues and possessed excellent pattern-substrate fidelity. In vitro studies confirmed the platform's biocompatibility and biodegradability. Finally, the potential controlled release of the Ag coating from the composite fibrous scaffolds could be beneficial for many clinical applications.
Center of Nanotechnology, King Abdulaziz University, Jeddah 21569, Saudi Arabia. amemic@kau.edu.sa.
Adnan
A
Memic
Center of Nanotechnology, King Abdulaziz University, Jeddah 21569, Saudi Arabia. musab.alzaheri@gmail.com.|Department of Biochemistry, King Abdulaziz University, Jeddah 21569, Saudi Arabia. musab.alzaheri@gmail.com.
Musab
M
Aldhahri
Biomaterials Innovation Research Center (BIRC), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA. atamayol@mit.edu.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. atamayol@mit.edu.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. atamayol@mit.edu.
Ali
A
Tamayol
Biomaterials Innovation Research Center (BIRC), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA. pooriam@mit.edu.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. pooriam@mit.edu.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. pooriam@mit.edu.
Pooria
P
Mostafalu
Center of Nanotechnology, King Abdulaziz University, Jeddah 21569, Saudi Arabia. mshabaan90@yahoo.com.
Mohamed Shaaban
MS
Abdel-Wahab
Biomaterials Innovation Research Center (BIRC), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA. mehdisam@mit.edu.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. mehdisam@mit.edu.
Mohamadmahdi
M
Samandari
Biomaterials Innovation Research Center (BIRC), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA. Kamyar.Mollazadeh@gmail.com.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Kamyar.Mollazadeh@gmail.com.
Kamyar Mollazadeh
KM
Moghaddam
Biomaterials Innovation Research Center (BIRC), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA. n.annabi@neu.edu.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. n.annabi@neu.edu.|Department of Chemical Engineering, Northeastern University, Boston, MA 02115-5000, USA. n.annabi@neu.edu.
Nasim
N
Annabi
Department of Chemical Engineering, Northeastern University, Boston, MA 02115-5000, USA. s.bencherif@northeastern.edu.|Sorbonne University, UTC CNRS UMR 7338, Biomechanics and Bioengineering (BMBI), University of Technology of Compiègne, BP 20529, Rue Personne de Roberval, 60205 Compiègne, France. s.bencherif@northeastern.edu.|School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. s.bencherif@northeastern.edu.
Sidi A
SA
Bencherif
Center of Nanotechnology, King Abdulaziz University, Jeddah 21569, Saudi Arabia. alik@rics.bwh.harvard.edu.|Biomaterials Innovation Research Center (BIRC), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA. alik@rics.bwh.harvard.edu.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. alik@rics.bwh.harvard.edu.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. alik@rics.bwh.harvard.edu.|Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul 05029, Korea. alik@rics.bwh.harvard.edu.
Ali
A
Khademhosseini
electrical properties; electrospinning; flexible electronics; nanocoatings