Surgical treatment of adhesion-related chronic abdominal and pelvic pain after gynaecological and general surgery: a systematic review and meta-analysis.
Chronic pain is a frequent post-operative complication, affecting ~20-40% of patients who have undergone surgery of the female genital or alimentary tract. Chronic pain is an important risk factor for diminished quality of life after surgery. Adhesions are frequently associated with chronic post-operative pain; however, surgical treatment of adhesion-related pain is controversial.



The aim of this study was to investigate the efficacy and harms of surgical interventions for chronic post-operative pain attributable to adhesions.



A search was conducted using PubMed, EMBASE and CENTRAL, without restrictions pertaining to date, publication status or language. Randomized trials and cohort studies from all surgical interventions for chronic post-operative pain were considered eligible. Patients with a concomitant diagnosis that could cause chronic pain (e.g. endometriosis or inflammatory conditions) were excluded. Outcome measures were graded according to clinical relevance, with improvement of pain at long-term follow-up regarded as most clinically relevant.



A total of 4294 unique citations were identified, of which 13 studies met the criteria for inclusion. Two of the analysed studies were randomized trials, of which one had a low risk of bias. Only one trial, randomizing between laparoscopic adhesiolysis without an adhesion barrier and diagnostic laparoscopy, reported improvement of pain at long-term follow-up. In this trial, pain improved in 55.8% of patients after adhesiolysis and in 41.7% of patients in the control group; however, the difference was not significant (relative risk (RR) 1.34; 95% CI: 0.89-2.02). Most non-randomized studies had mid-length follow-up (6-12 months). In pooled analyses of trials and non-randomized studies, improvement of pain was reported in 72% of patients who underwent adhesiolysis (95% CI: 61-83%) at any follow-up longer than 3 months. The incidence of negative laparoscopies was 20% (95% CI: 10-30%). The overall incidence of complications following laparoscopic adhesiolysis was 4% (95% CI: 1-6%).



Laparoscopic adhesiolysis reduces pain from adhesions in ~70% of patients in the initial phase after treatment. However, there is little evidence for long-term efficacy of adhesiolysis for chronic pain. Other drawbacks of laparoscopic adhesiolysis are the high rate of negative laparoscopies and the risk of bowel injury. At present, there is little evidence to support routine use of adhesiolysis in treatment for chronic pain. New research is needed to investigate whether the results of adhesiolysis can be improved with new techniques for diagnosis and prevention of adhesion reformation.
Radboud University Medical Centre, Department of Surgery, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Barend A
BA
van den Beukel
Radboud University Medical Centre, Department of Surgery, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Roy
R
de Ree
Radboud University Medical Centre, Department of Surgery, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Suzanne
S
van Leuven
Onze Lieve Vrouwe Gasthuis, Department of Obstetrics and Gynaecology, PO Box 95500, 1090 HM Amsterdam, The Netherlands.
Erica A
EA
Bakkum
Radboud University Medical Centre, Department of Surgery, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Chema
C
Strik
Radboud University Medical Centre, Department of Surgery, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Harry
H
van Goor
Radboud University Medical Centre, Department of Surgery, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Richard P G
RPG
Ten Broek
D015746:Abdominal Pain / Q000209:etiology / Q000601:surgery*; D059350:Chronic Pain / Q000209:etiology / Q000601:surgery*; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D017699:Pelvic Pain / Q000209:etiology / Q000601:surgery*; D011183:Postoperative Complications / Q000601:surgery*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D000267:Tissue Adhesions / Q000150:complications / Q000601:surgery*; D016896:Treatment Outcome
adhesiolysis; adhesion prevention; adhesions; chronic pain; laparoscopy; laparotomy