Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues.
BACKGROUND
To manage the complications of irradiation of head and neck tissue is a challenging issue for the otolaryngologist. Definitive treatment of these complications is still controversial. Recently, hyperbaric oxygen therapy is promising option for these complications.


OBJECTIVE
In this study, we used biochemical and histopathological methods to investigate the efficacy of hyperbaric oxygen against the inflammatory effects of radiotherapy in blood and laryngeal tissues when radiotherapy and hyperbaric oxygen are administered on the same day.


METHODS
Thirty-two Wistar Albino rats were divided into four groups. The control group was given no treatment, the hyperbaric oxygen group was given only hyperbaric oxygen therapy, the radiotherapy group was given only radiotherapy, and the radiotherapy plus hyperbaric oxygen group was given both treatments on the same day.


RESULTS
Histopathological and biochemical evaluations of specimens were performed. Serum tumor necrosis factor-α, interleukin-1β, and tissue inflammation levels were significantly higher in the radiotherapy group than in the radiotherapy plus hyperbaric oxygen group, whereas interleukin-10 was higher in the radiotherapy plus hyperbaric oxygen group.


CONCLUSIONS
When radiotherapy and hyperbaric oxygen are administered on the same day, inflammatory cytokines and tissue inflammation can be reduced in an early period of radiation injury.
Necmettin Erbakan University, Department of Otorhinolaryngology Head and Neck Surgery, Konya, Turkey. Electronic address: maricigil79@gmail.com.
Mitat
M
Arıcıgil
Necmettin Erbakan University, Department of Otorhinolaryngology Head and Neck Surgery, Konya, Turkey.
Mehmet Akif
MA
Dündar
Horasan State Hospital, Department of Otorhinolaryngology Head and Neck Surgery, Erzurum, Turkey.
Abitter
A
Yücel
Necmettin Erbakan University, Department of Otorhinolaryngology Head and Neck Surgery, Konya, Turkey.
Hamdi
H
Arbağ
Necmettin Erbakan University, Department of Undersea and Hyperbaric Medicine, Konya, Turkey.
Abdullah
A
Arslan
Necmettin Erbakan University, Department of Radiation Oncology, Konya, Turkey.
Meryem
M
Aktan
Necmettin Erbakan University, Department of Pathology, Konya, Turkey.
Sıdıka
S
Fındık
Necmettin Erbakan University, Department of Biochemistry, Konya, Turkey.
İbrahim
İ
Kılınç
D000818:Animals; D005260:Female; D006931:Hyperbaric Oxygenation; D007249:Inflammation / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D016753:Interleukin-10 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D009333:Neck; D018384:Oxidative Stress; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
Hyperbaric oxygen; Inflamação; Inflammation; Neck radiotherapy; Oxigênio hiperbárico; Radioterapia de pescoço