A parameterized model for mean urinary inflow rate and its preliminary application in radiotherapy for cervical cancer.
Forty-nine patients with stage IIbcervical cancer were included to investigate the changes in bladder volume in response to different approaches to maintaining consistent bladder filling. The impacts of age (Page), water consumption (Pwat), and body mass index (BMI, Pbmi) on the mean urinary inflow rate (vtot) were analysed. The bladder volume (BV) increased linearly over time. A large variation in vtotamong individuals was observed, ranging from 0.19 to 5.13 ml/min. The vtotwas correlated with Page(R = -0.53, p = 0.01) and Pwat(R = 0.84, p = 0.00), and no correlation between vtotand Pbmiwas found (p > 0.05). Therefore, vtotcould be parameterized using two methods: multivariable linear regression and iterative fitting. There was no statistically significant difference between the two methods. The model accuracy was successfully assessed with several validation tests for patients with good compliance (79.2% of all patients), and the proportion of radiotherapy (RT) fractions with zero wait time (one ultrasound (US) scan) increased from 6.5% to 41.2%. The optimal US scanning number and RT time could be provided using this model. This adaptive RT approach could reduce patient discomfort caused by holding onto urine and reduce technician labour as well as cost.
Division of Physics, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.|Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Fu
F
Jin
Division of Physics, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.|Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Huan-Li
HL
Luo
Forensic Identification Center, College of Criminal Investigation, Southwest University of Political Science and Law, Chongqing, People's Republic of China.
Juan
J
Zhou
Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Ding-Yi
DY
Yang
Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Li
L
Yin
Medical Information and Engineering School, Southwest Medical University, Luzhou, People's Republic of China.
Xiao-Qing
XQ
Yang
Division of Physics, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.|Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Ya-Nan
YN
He
Division of Physics, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.|Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Xian-Feng
XF
Liu
Division of Physics, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.|Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Da
D
Qiu
Division of Physics, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.|Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Ming-Song
MS
Zhong
Division of Physics, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.|Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Han
H
Yang
Division of Physics, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.|Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Chao
C
Li
Division of Physics, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.|Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Qi-Cheng
QC
Li
Division of Physics, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.|Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Guang-Lei
GL
He
Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China. jfazj@126.com.
Ying
Y
Wang
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007206:Individuality; D008875:Middle Aged; D015233:Models, Statistical; D001743:Urinary Bladder / Q000033:anatomy & histology* / Q000502:physiology*; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*