CTLA-4 gene polymorphisms associate with efficacy of postoperative radioiodine-131 for differentiated thyroid carcinoma.
OBJECTIVE
To investigate the association of CTLA-4 polymorphisms with efficacy of postoperative radioiodine-131 (I-131) treatment for differentiated thyroid carcinoma (DTC).


METHODS
A total of 324 DTC patients and 350 healthy individuals were enrolled in our study. Patients received I-131 remnant ablation following surgical resection. Based on the treatment efficacy, patients were divided into the effective (n = 183) and ineffective groups (n = 141). CTLA-4 polymorphisms (+49A>G, CT60A>G and -318C>T) were genotyped by polymerase chain reaction-restriction fragment length polymorphism.


RESULTS
AG + AA genotype distribution and A allele frequency of +49A>G and CT60A>G polymorphisms were higher in the effective group than the ineffective group.


CONCLUSIONS
+49A>G and CT60A>G polymorphisms were associated with the efficacy of postoperative I-131 treatment for DTC; and they might be bioindicators related to the prognosis of I-131 treatment.
The 2nd Department of General Surgery, Heilongjiang Provincial Hospital, Harbin 150030, China.
De-Feng
DF
Chang
The 2nd Department of General Surgery, Heilongjiang Provincial Hospital, Harbin 150030, China.
Xiao-Hong
XH
Chen
Department of Anesthesiology, Heilongjiang Provincial Hospital, Harbin 150030, China.
Jing
J
Huang
The 2nd Department of General Surgery, Heilongjiang Provincial Hospital, Harbin 150030, China.
Ya-Mei
YM
Sun
The 2nd Department of General Surgery, Heilongjiang Provincial Hospital, Harbin 150030, China.
Da-Yong
DY
Zhu
The 2nd Department of General Surgery, Heilongjiang Provincial Hospital, Harbin 150030, China.
Zhong-Qing
ZQ
Xu
D000483:Alleles; D015415:Biomarkers; D060908:CTLA-4 Antigen / Q000235:genetics*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use; D053208:Kaplan-Meier Estimate; D008297:Male; D060787:Neoplasm Grading; D020641:Polymorphism, Single Nucleotide; D011182:Postoperative Care; D011379:Prognosis; D012008:Recurrence; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D016896:Treatment Outcome
D015415:Biomarkers; D060908:CTLA-4 Antigen; D007457:Iodine Radioisotopes
+49A>G; -318C>T; CT60A>G; CTLA-4 gene; differentiated thyroid carcinoma; efficacy; polymorphism; radioiodine-131