Predicting dementia using socio-demographic characteristics and the Free and Cued Selective Reminding Test in the general population.
BACKGROUND
Our study aimed to determine whether the consideration of socio-demographic features improves the prediction of Alzheimer's dementia (AD) at 5 years when using the Free and Cued Selective Reminding Test (FCSRT) in the general older population.


METHODS
Our analyses focused on 2558 subjects from the prospective Three-City Study, a cohort of community-dwelling individuals aged 65 years and over, with FCSRT scores. Four "residual scores" and "risk scores" were built that included the FCSRT scores and socio-demographic variables. The predictive performance of crude, residual and risk scores was analyzed by comparing the areas under the ROC curve (AUC).


RESULTS
In total, 1750 subjects were seen 5 years after completing the FCSRT. AD was diagnosed in 116 of them. Compared with the crude free-recall score, the predictive performances of the residual score and of the risk score were not significantly improved (AUC: 0.83 vs 0.82 and 0.88 vs 0.89 respectively).


CONCLUSIONS
Using socio-demographic features in addition to the FCSRT does not improve its predictive performance for dementia or AD.
Neuropsychiatry: Epidemiological and Clinical Research, INSERM U1061, 34093, Montpellier, Cedex 5, France. t-mura@chu-montpellier.fr.|University of Montpellier, Montpellier, France. t-mura@chu-montpellier.fr.|Medical Information Department, University Hospital of Montpellier, Montpellier, France. t-mura@chu-montpellier.fr.
Thibault
http://orcid.org/0000-0001-6420-1336
T
Mura
Neuropsychiatry: Epidemiological and Clinical Research, INSERM U1061, 34093, Montpellier, Cedex 5, France.
Marieta
M
Baramova
Neuropsychiatry: Epidemiological and Clinical Research, INSERM U1061, 34093, Montpellier, Cedex 5, France.|University of Montpellier, Montpellier, France.|Memory Consultation, Centre Mémoire de Ressource et de Recherche, Gui de Chauliac University Hospital, Montpellier, France.
Audrey
A
Gabelle
Neuropsychiatry: Epidemiological and Clinical Research, INSERM U1061, 34093, Montpellier, Cedex 5, France.
Sylvaine
S
Artero
Memory Consultation, Centre Mémoire de Ressource et de Recherche, University Hospital, Bordeaux, France.|ISPED, Centre INSERM U1219, Bordeaux Population Health Research Center, Bordeaux, France.|University of Bordeaux,, Centre INSERM U1219, Bordeaux Population Health Research Center, Bordeaux, France.
Jean-François
JF
Dartigues
ISPED, Centre INSERM U1219, Bordeaux Population Health Research Center, Bordeaux, France.|University of Bordeaux,, Centre INSERM U1219, Bordeaux Population Health Research Center, Bordeaux, France.
Hélène
H
Amieva
Neuropsychiatry: Epidemiological and Clinical Research, INSERM U1061, 34093, Montpellier, Cedex 5, France.|University of Montpellier, Montpellier, France.
Claudine
C
Berr
D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015984:Causality; D015897:Comorbidity; D003463:Cues; D003704:Dementia / Q000175:diagnosis* / Q000453:epidemiology*; D004522:Educational Status; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D000073216:Mental Status and Dementia Tests; D015995:Prevalence; D011379:Prognosis; D016016:Proportional Hazards Models; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D012959:Socioeconomic Factors
Alzheimer disease; Dementia; Early clinical trial; Prediction; preclinical Alzheimer disease; prodromal Alzheimer disease