Generation of diversity in thymic epithelial cells.
In the thymus, diverse populations of thymic epithelial cells (TECs), including cortical and medullary TECs and their subpopulations, have distinct roles in coordinating the development and repertoire selection of functionally competent and self-tolerant T cells. Here, we review the expanding diversity in TEC subpopulations in relation to their functions in T cell development and selection as well as their origins and development.
Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan.
Yousuke
Y
Takahama
Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan.
Izumi
I
Ohigashi
Institute for Immunology and Immunotherapy, Medical School, University of Birmingham, Birmingham B15 2TT, UK.
Song
S
Baik
Institute for Immunology and Immunotherapy, Medical School, University of Birmingham, Birmingham B15 2TT, UK.
Graham
G
Anderson
D000818:Animals; D018925:Chemokines / Q000276:immunology; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D060168:Thymocytes / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology* / Q000196:embryology / Q000378:metabolism
D018925:Chemokines