Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents.
A series of ten novel chalcone incorporated quinazoline derivatives (11a-11j) were designed and synthesized. All the synthesized compounds were evaluated for their anticancer activities against four human cancer cell lines (A549, HT-29, MCF-7 and A375). Among them, four compounds,11f,11g,11iand11jshowed more potent anticancer activity than the control drug, Combretastatin - A4.
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522510, Andhra Pradesh, India.
Sapavat
S
Madhavi
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522510, Andhra Pradesh, India.
Reddymasu
R
Sreenivasulu
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522510, Andhra Pradesh, India.
Jyothsna Pragathi
JP
Yazala
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522510, Andhra Pradesh, India.
Rudraraju Ramesh
RR
Raju
Chalcones; Cytotoxicity; Erlotinib; Gefitinib; Quinazolines; Resveratrol