Hemodynamic Consequences of Changes in Microvascular Structure.
In hypertension, an increased media-to-lumen ratio of small resistance arteries might play an important role in the increase of vascular resistance, and may also be an adaptive response to the increased hemodynamic load. The presence of morphological alteration in the microvasculature may be associated to an impaired tissue perfusion and/or to the development of target organ damage. Structural alterations in the microcirculation might represent a predictor of the onset of cardio-cerebrovascular events and hypertension complications. A cross-talk between the small and large artery may exaggerate arterial damage, following a vicious circle. Therefore, in the present review, possible hemodynamic consequences of the presence of microvascular structural alterations will be considered, in terms of their time of onset, role in the development and/or maintenance of high blood pressure values, and interrelationships with structural/mechanical alterations of large conductance arteries.
Clinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.|Istituto Clinico Città di Brescia, Division of Medicine, Brescia, Italy.
Damiano
D
Rizzoni
Clinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Claudia
C
Agabiti-Rosei
Clinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Enrico
E
Agabiti-Rosei
D000273:Adipose Tissue / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D062186:Arterial Pressure; D001158:Arteries / Q000473:pathology / Q000503:physiopathology*; D018450:Disease Progression; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D008833:Microcirculation; D055806:Microvessels / Q000473:pathology / Q000503:physiopathology*; D011379:Prognosis; D066253:Vascular Remodeling; D014655:Vascular Resistance
blood pressure; hemodynamics; hypertension; microcirculation; remodeling; small arteries