Combating blood stream infections during induction chemotherapy in children with acute myeloid leukemia: Single center results in India.
Optimal management of infectious complication is the biggest challenge in children receiving chemotherapy for acute myeloid leukemia (AML). We have analyzed the data of children undergoing AML induction chemotherapy at our center from 2002 to 2016 and found that Gram-negative infections are more predominant when compared to the published literature. There also has been a surge in multidrug-resistant (MDR) infections over the last 4 years, which has increased the need for supportive care and escalated the cost of care. We have introduced certain novel methods to combat MDR sepsis and decrease mortality rates.
Department of Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Apollo Speciality Hospital, Chennai, India.
Divya
D
Subburaj
Department of Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Apollo Speciality Hospital, Chennai, India.
Ramya
R
Uppuluri
Department of Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Apollo Speciality Hospital, Chennai, India.
Dhaarani
D
Jayaraman
Department of Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Apollo Speciality Hospital, Chennai, India.
Venkateshwaran
V
Vellaichamyswaminathan
Department of Pediatric Critical Care Group, Apollo Speciality Hospital, Chennai, India.
Sathishkumar
S
Kandath
Department of Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Apollo Speciality Hospital, Chennai, India.
Revathi
R
Raj
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003365:Costs and Cost Analysis; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000191:economics; D006801:Humans; D007194:India; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000191:economics / Q000382:microbiology; D008297:Male
AML; BSI; MDR organisms; supportive care