Tissue expression of human epididymal secretory protein 4 may be useful in the differential diagnosis of uterine cervical tumors.
Human Epididymal Secretory Protein 4 was firstly described as an epididymis-specific protein but more recently it has been demonstrated to be a putative serum tumor marker for different malignancies, especially ovarian epithelial cancers. The aim of this study is to investigate the association between tissue Human Epididymal Secretory Protein 4 expression and the clinicopathological features of uterine cervical tumors.



This retrospective study was designed to evaluate the differences of tissue expressions of Human Epididymal Secretory Protein 4 protein in a spectrum of cervical neoplasms. One hundred and seven patients recently diagnosed as having cervical intraepithelial neoplasm or invasive squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma based on pathology databases.



Decreased or negative Human Epididymal Secretory Protein 4 expressions were determined in both normal cervical epithelia and in intraepithelial carcinomas, while increased HE4 expression was observed in invasive tumors.



This study demonstrated that altered expression of Human Epididymal Secretory Protein 4 may involve in tumorigenesis in the uterine cervix. Our findings also suggested the presence of a correlation between Human Epididymal Secretory Protein 4 expression and the invasive potential of uterine tumors. Therefore it may be thought that the tissue expression of HE4 can be used to differentiate high grade intraepithelial tumors from carcinomas.
Tepecik Training and Research Hospital, Department of Pathology, Izmir, Turkey. agdiniz@gmail.com.
Gulden
G
Diniz
Tugba
T
Karadeniz
Sevil
S
Sayhan
Talya
T
Akata
Fatma
F
Aydiner
Duygu
D
Ayaz
Dudu
D
Solakoglu Kahraman
Tulay
T
Akman
D000230:Adenocarcinoma / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018196:Carcinoma, Adenosquamous / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011506:Proteins / Q000378:metabolism*; D065310:Squamous Intraepithelial Lesions of the Cervix / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*; D000081102:WAP Four-Disulfide Core Domain Protein 2; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000378:metabolism*
D014408:Biomarkers, Tumor; D011506:Proteins; D000081102:WAP Four-Disulfide Core Domain Protein 2; C569698:WFDC2 protein, human
HE4; Human Epididymal Secretory Protein 4; Uterine cervix; adenocarcinoma; adenosquamous carcinoma; squamous cell carcinoma