TRPC6 and kidney disease: sclerosing more than just glomeruli?
Fibrosis is a common response to injury but can also perpetuate tissue dysfunction. Transient receptor potential C6 (TRPC6) is implicated in cardiac and skin healing via regulation of myofibroblast differentiation. Wu et al. now demonstrate a role for TRPC6 in renal fibrosis, via a mechanism that also relies on TRPC3 and is antagonized by soluble klotho. Modulation of TRPC3/6 activity may provide a means of dampening the fibrotic response involved in chronic kidney disease progression.
Beth Israel Deaconess Medical Center and Harvard Medical School, Division of Nephrology, Boston, Massachusetts, USA. Electronic address: jschlond@bidmc.harvard.edu.
Johannes
J
Schlondorff
D002454:Cell Differentiation; D005355:Fibrosis; D006801:Humans; D051436:Renal Insufficiency, Chronic; D050052:TRPC Cation Channels; D000074287:TRPC6 Cation Channel
D050052:TRPC Cation Channels; D000074287:TRPC6 Cation Channel; C117032:TRPC6 protein, human