Storage of platelet concentrates harvested from blood collected into dextrose-free preservative without agitation.
This study addresses the possibility of platelet quality being maintained during storage by an endogenous metabolic fuel, while avoiding dextrose-induced lactate accumulation. This was achieved by harvesting platelet concentrates from blood donations collected into a dextrose-free anticoagulant. Adequate maintenance of all metabolic and functional parameters was observed in platelets from blood collected into 4% citrate. The requirement for platelets stored in CPD plasma to be agitated during storage was confirmed, but agitation could be omitted for dextrose-free platelets without increased lactate generation and a drop in pH. These results indicate that platelet concentrates from dextrose-free blood may be stored without some of the constraints accompanying platelet storage in conventional media, and may thus result in improved delivery of this product.
Product Development Unit, Victoria Red Cross Blood Bank, cnr Balston & Kavanagh Streets, South Melbourne, Victoria, Australia 3205.
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Farrugia
Product Development Unit, Victoria Red Cross Blood Bank, cnr Balston & Kavanagh Streets, South Melbourne, Victoria, Australia 3205.
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Douglas
Product Development Unit, Victoria Red Cross Blood Bank, cnr Balston & Kavanagh Streets, South Melbourne, Victoria, Australia 3205.
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Karabagias
Product Development Unit, Victoria Red Cross Blood Bank, cnr Balston & Kavanagh Streets, South Melbourne, Victoria, Australia 3205.
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Gutowski
Product Development Unit, Victoria Red Cross Blood Bank, cnr Balston & Kavanagh Streets, South Melbourne, Victoria, Australia 3205.
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Ram
agitation; dextrose; platelet concentrates; storage