Cutting Edge in IFN Regulation: Inflammatory Caspases Cleave cGAS.
Caspases have important functions beyond their established role in driving inflammation and apoptosis. In this issue of Immunity, Wang et al. (2017) demonstrate that inflammasome-triggered caspases cleave and inactivate the DNA sensor cGAS, thus restricting the type I interferon response to cytosolic DNA.
III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
Simon
S
Heidegger
III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
Tobias
T
Haas
III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany. Electronic address: hendrik.poeck@tum.de.
Hendrik
H
Poeck
D020169:Caspases; D003600:Cytosol / Q000276:immunology; D006801:Humans; D058847:Inflammasomes; D007370:Interferon Type I; D009713:Nucleotidyltransferases / Q000235:genetics*
D058847:Inflammasomes; D007370:Interferon Type I; D009713:Nucleotidyltransferases; D020169:Caspases