Embryonal Origin of MTSCC of Kidney May Explain its Morphological Heterogeneity: Diagnostic Impact of Genetic Analysis.
Previous genetic and morphologic characterisation of mucinous tubular and spindle cell carcinoma (MTSCC) have yielded controversial results. The aim of this study was to explain the phenotypic heterogeneity of MTSCC diagnosed by genetic means.



We analyzed 7 MTSCC by array CGH and microsatellite allelotyping and by histology for morphological variation. We worked-up two entire kidneys with MTSCC to find microscopic alterations.



We confirmed the diagnosis of MTSCC by detecting copy number changes at chromosomes 1, 4, 6, 8, 13, 14, 15, 18 and 22. We detected 13 small, microscopic precursor lesions in the two kidneys and found similar histological structures in precursor lesions and MTSCC.



MTSCC develops from embryonal rest-like lesions of impaired differentiation which may explain its morphological variations. Until diagnosis of a "malignant" MTSCC" is not confirmed by genetic means, it should not be called carcinoma.
Department of Urology, Medical School, University of Pecs, Pecs, Hungary.
Daniel
D
Banyai
Department of Urology, Medical School, University of Pecs, Pecs, Hungary.
Fanni
F
Vastag
Medical Faculty, Ruprecht-Karls-University, Heidelberg, Germany.
Maria
M
Yusenko
Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University and German Red Cross Blood Service Baden-Württemberg - Hessen, Mannheim, Germany.
Peter
P
Bugert
Department of Urology, Medical School, University of Pecs, Pecs, Hungary G.Kovacs@gmx.de gyula.kovacs@urz.uni-heidelberg.de.|Medical Faculty, Ruprecht-Karls-University, Heidelberg, Germany.
Gyula
G
Kovacs
D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000483:Alleles; D002454:Cell Differentiation; D019070:Cell Lineage; D055028:Comparative Genomic Hybridization; D005260:Female; D005820:Genetic Testing; D006801:Humans; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D010641:Phenotype; D012509:Sarcoma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology
Mucinous tubular and spindle cell carcinoma; array CGH; microsatellite analysis; morphological heterogeneity; precursor lesion