NMR reaction monitoring in flow synthesis.
Recent advances in the use of flow chemistry with in-line and on-line analysis by NMR are presented. The use of macro- and microreactors, coupled with standard and custom made NMR probes involving microcoils, incorporated into high resolution and benchtop NMR instruments is reviewed. Some recent selected applications have been collected, including synthetic applications, the determination of the kinetic and thermodynamic parameters and reaction optimization, even in single experiments and on the μL scale. Finally, software that allows automatic reaction monitoring and optimization is discussed.
Área Química Orgánica, Facultad de Químicas, Universidad de Castilla-La Mancha, Avda. Camilo José Cela nº 10, E-13071 Ciudad Real, Spain and Instituto Regional de Investigación Científica Aplicada (IRICA), Avda. Camilo José Cela s/n, E-13071 Ciudad Real, Spain.
M Victoria
MV
Gomez
Área Química Orgánica, Facultad de Químicas, Universidad de Castilla-La Mancha, Avda. Camilo José Cela nº 10, E-13071 Ciudad Real, Spain and Instituto Regional de Investigación Científica Aplicada (IRICA), Avda. Camilo José Cela s/n, E-13071 Ciudad Real, Spain.
Antonio
A
de la Hoz
NMR probes; expert systems; flow chemistry; microcoil