Recent Progress in 808 nm Excited Upconversion Nanomaterials as Multifunctional Nanoprobes for Visualized Theranostics in Cancers.
Near-infrared (NIR) light responsive nanomaterials have attracted considerable attention due to their location in the biological window. Especially, lanthanide-doped nanomaterials exhibit unique upconversion luminescence (UCL) properties with low background interference and long luminescence lifetime, which makes them promising in imaging diagnosis of cancers. Compared with traditional upconversion nanomaterials excited by 980 nm laser, 808 nm excitation can overcome the disadvantages of high heating effect and weak penetration depth induced by excitation source. Therefore, developing 808 nm excited upconversion nanoprobes will be important for the in vivo bio-imaging and visualized theranostics of tumors in deep-tissue. In the review paper, we systematically summarized the synthesis strategy and luminescence modulation of Nd3+-sensitized upconversion nanomaterials under 808 nm excitation, discussed the influence of excitation source on heating effect and penetration depth, and particularly focused on their applications in UCL imaging, multi-modal imaging and imaging-guided therapy of cancers.
Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, China.|Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, College of Chemistry & Environmental Science, Hebei University, Baoding, 071002, China.|Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, China.
Leyong
L
Zeng
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, College of Chemistry & Environmental Science, Hebei University, Baoding, 071002, China.
Di
D
Wu
Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, China.
Ying
Y
Tian
Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, China.
Yuanwei
Y
Pan
Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, China.
Aiguo
A
Wu
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, College of Chemistry & Environmental Science, Hebei University, Baoding, 071002, China.
Jinchao
J
Zhang
Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, China.
Guangming
G
Lu
D000818:Animals; D006801:Humans; D049329:Nanostructures / Q000032:analysis* / Q000737:chemistry / Q000627:therapeutic use*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D000068936:Theranostic Nanomedicine
Nd3+-sensitized upconversion nanomaterials; low-heating effect; multi-modal imaging; strong penetration depth; upconversion
luminescence imaging; visualized theranostics.