[Nontuberculous mycobacteria].
Dermatologically relevant nontuberculous mycobacteria (NTM) include Mycobacterium marinum and Mycobacterium ulcerans and different rapidly growing mycobacteria (RGM). RGM are widely present in the environment and are facultative pathogenic. Diagnostic detection of nontuberculous mycobacteria is frequently challenging. Immune-competent individuals mostly develop localized infections. Immune-suppressed patients may present with severe and disseminated disease. In these cases, rapid initiation of medical treatment is important. Moreover, infections with the more aggressive Mycobacterium ulcerans should be treated early. Due to the risk for the development of inducible antibiotic resistance, antibiotic regimes for NTM infections typically require at least two drugs. Surgical treatment should also be considered. This article discusses clinical presentation, diagnostic workup, and in particular antibiotic treatment options for dermatologically relevant infections caused by NTM.
Klinik und Poliklinik für Dermatologie und Venerologie, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland.
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Emmerich
Klinik und Poliklinik für Dermatologie und Venerologie, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland. mario.fabri@uk-koeln.de.
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Fabri
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy / Q000379:methods; D062109:Dermatologic Surgical Procedures / Q000379:methods*; D003937:Diagnosis, Differential; D019317:Evidence-Based Medicine; D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects* / Q000302:isolation & purification; D017192:Skin Diseases, Bacterial / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents
Antibiotics; Buruli ulcer; Fish tank granuloma; Mycobacterium marinum; Mycobacterium ulcerans