An event-related potential study on the time course of mental rotation in upper-limb amputees.
Mental rotation of body parts involves sequential cognitive processes, including visual processing, categorization and the mental rotation process itself. However, how these processes are affected by the amputation of a limb is still unclear.



Twenty-five right upper-limb amputees and the same number of matched healthy controls participated in a hand mental rotation task. Thirty-two-channel electroencephalography (EEG) was recorded and the event-related potentials (ERPs) were analyzed.



In the early visual processing phase, amputees and controls showed a similar P100. During the categorization phase, the amputees exhibited a decreased N200 compared with controls, and the decline was positively correlated with the time since amputation. In the mental rotation phase, controls had a larger ERP for the right upright hand than for the left upright hand, while amputees had a larger ERP for the left (intact) upright hand than for the right (affected) upright hand.



Early visual processing was not affected by limb amputation. However, the perceptual salience of hand pictures decreased and the intact hand gained more significance in the amputees.



Event-related potentials had the capability of showing the differences in categorization and mental rotation phases between amputees and controls.
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim 68159, Germany.
Yuanyuan
Y
Lyu
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: meagle@sjtu.edu.cn.
Xiaoli
X
Guo
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim 68159, Germany.
Robin
R
Bekrater-Bodmann
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim 68159, Germany.
Herta
H
Flor
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: stong@sjtu.edu.cn.
Shanbao
S
Tong
D000328:Adult; D000674:Amputees; D016022:Case-Control Studies; D003071:Cognition; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D011930:Reaction Time; D012399:Rotation; D034941:Upper Extremity / Q000294:innervation / Q000503:physiopathology; D014796:Visual Perception
Amputation; Event-related potential (ERP); Mental rotation; N200; P300; Rotation-related negativity (RRN)