Vitamin D receptor expression and hepcidin levels in the protection or severity of leprosy: a systematic review.
Leprosy is a chronic infectious disease whose disequilibrium in the host's genetic, immunological and clinical mechanisms leads to distinct manifestations defining the type of immunological response. This review focuses its attention on the influence of the Vitamin D Receptor and hepcidin expressions that can suggest the protection or severity of leprosy.
Post-graduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil. Electronic address: analauragrossi@gmail.com.
Ana Laura Grossi de
ALG
Oliveira
Post-graduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Ana Thereza
AT
Chaves
Department of Clinical and Toxicological Analyses, School of Pharmacy, UFMG, Brazil.
Cristiane Alves Silva
CAS
Menezes
Post-graduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Nathalia Sernizon
NS
Guimarães
Department of Parasitology, Institute of Biological Sciences, UFMG, Brazil.
Lilian Lacerda
LL
Bueno
Post-graduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Ricardo Toshio
RT
Fujiwara
Post-graduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Manoel Otávio da Costa
MODC
Rocha
D016208:Databases, Factual; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000517:prevention & control; D064451:Hepcidins / Q000097:blood* / Q000235:genetics; D006801:Humans; D007918:Leprosy / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000097:blood / Q000235:genetics*
D064451:Hepcidins; D018167:Receptors, Calcitriol
Hepcidin; Leprosy; Polymorphism; Protection; Severity; Vitamin D receptor