New mechanistic interpretations for nitrone reactivity.
The reactivity of nitrones in cycloadditions and related reactions is revisited by introducing a topological perspective. In particular, the study of electron localization function (ELF) along a reaction pathway allows evaluating bond reorganization showing that in several cases the bonds are formed in a sequential way, the second one being formed once the first one is already formed. Both classical 1,3-dipolar cycloadditions and Mannich-type reactions revealed unexpected features often underestimated in classical mechanistic studies.
Instituto de Biocomputación y Fisica de Sistemas Complejos (BIFI), Universidad de Zaragoza, Campus San Francisco, 50009 Zaragoza, Aragón, Spain. pmerino@unizar.es.
Pedro
P
Merino
Tomás
T
Tejero
Ignacio
I
Delso
Rosa
R
Matute