The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson's disease.
Adaptive deep brain stimulation uses feedback about the state of neural circuits to control stimulation rather than delivering fixed stimulation all the time, as currently performed. In patients with Parkinson's disease, elevations in beta activity (13-35 Hz) in the subthalamic nucleus have been demonstrated to correlate with clinical impairment and have provided the basis for feedback control in trials of adaptive deep brain stimulation. These pilot studies have suggested that adaptive deep brain stimulation may potentially be more effective, efficient and selective than conventional deep brain stimulation, implying mechanistic differences between the two approaches. Here we test the hypothesis that such differences arise through differential effects on the temporal dynamics of beta activity. The latter is not constantly increased in Parkinson's disease, but comes in bursts of different durations and amplitudes. We demonstrate that the amplitude of beta activity in the subthalamic nucleus increases in proportion to burst duration, consistent with progressively increasing synchronization. Effective adaptive deep brain stimulation truncated long beta bursts shifting the distribution of burst duration away from long duration with large amplitude towards short duration, lower amplitude bursts. Critically, bursts with shorter duration are negatively and bursts with longer duration positively correlated with the motor impairment off stimulation. Conventional deep brain stimulation did not change the distribution of burst durations. Although both adaptive and conventional deep brain stimulation suppressed mean beta activity amplitude compared to the unstimulated state, this was achieved by a selective effect on burst duration during adaptive deep brain stimulation, whereas conventional deep brain stimulation globally suppressed beta activity. We posit that the relatively selective effect of adaptive deep brain stimulation provides a rationale for why this approach could be more efficacious than conventional continuous deep brain stimulation in the treatment of Parkinson's disease, and helps inform how adaptive deep brain stimulation might best be delivered.
Medical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, UK.|Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.|Department of Neurology, Bern University Hospital and University of Bern, Switzerland.
Gerd
G
Tinkhauser
Medical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, UK.|Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Alek
A
Pogosyan
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK.
Simon
S
Little
University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Martijn
M
Beudel
Medical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, UK.|Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Damian M
DM
Herz
Medical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, UK.|Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Huiling
H
Tan
Medical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, UK.|Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Peter
P
Brown
D000328:Adult; D000368:Aged; D001611:Beta Rhythm; D046690:Deep Brain Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy*; D010865:Pilot Projects; D020531:Subthalamic Nucleus
Parkinson’s disease; basal ganglia; beta oscillations; closed-loop control; deep brain stimulation