Polyketide Synthase Modules Redefined.
Modular redefinition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of a module, has been challenged by Abe and co-workers in their recent study. With this new understanding has emerged renewed hope for engineering these assembly lines to produce new materials and medicines.
Department of Molecular Biosciences, The University of Texas at Austin, 100 E. 24th St., Austin, TX, 78712, USA.
Adrian T
0000-0002-4358-7628
AT
Keatinge-Clay
D000213:Acyl Carrier Protein / Q000378:metabolism; D000217:Acyltransferases / Q000378:metabolism; D000818:Animals; D001419:Bacteria / Q000737:chemistry / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D055162:Biocatalysis; D019295:Computational Biology; D019143:Evolution, Molecular; D064429:Fatty Acid Synthases / Q000378:metabolism; D006801:Humans; D048630:Polyketide Synthases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D061065:Polyketides / Q000378:metabolism*; D000072417:Protein Domains; D015202:Protein Engineering; D013379:Substrate Specificity
D000213:Acyl Carrier Protein; D061065:Polyketides; D048630:Polyketide Synthases; D000217:Acyltransferases; D064429:Fatty Acid Synthases
assembly lines; enzymology; evolution-guided engineering; modules; polyketides