A Bayesian subgroup analysis using collections of ANOVA models.
We develop a Bayesian approach to subgroup analysis using ANOVA models with multiple covariates, extending an earlier work. We assume a two-arm clinical trial with normally distributed response variable. We also assume that the covariates for subgroup finding are categorical and are a priori specified, and parsimonious easy-to-interpret subgroups are preferable. We represent the subgroups of interest by a collection of models and use a model selection approach to finding subgroups with heterogeneous effects. We develop suitable priors for the model space and use an objective Bayesian approach that yields multiplicity adjusted posterior probabilities for the models. We use a structured algorithm based on the posterior probabilities of the models to determine which subgroup effects to report. Frequentist operating characteristics of the approach are evaluated using simulation. While our approach is applicable in more general cases, we mainly focus on the 2 × 2 case of two covariates each at two levels for ease of presentation. The approach is illustrated using a real data example.
Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH, 45221, USA.
Jinzhong
J
Liu
Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH, 45221, USA.
Siva
S
Sivaganesan
Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Purushottam W
PW
Laud
Department of Mathematics, University of Texas, Austin, TX, 78712, USA.
Peter
P
Müller
D000465:Algorithms; D000704:Analysis of Variance; D001499:Bayes Theorem; D001699:Biometry / Q000379:methods*; D006801:Humans; D015233:Models, Statistical; D011336:Probability
Bayes; Subgroup analysis