Essential Oil Composition and Bioactivities of Waldheimia glabra (Asteraceae) from Qinghai-Tibet Plateau.
Waldheimia glabra is traditionally used as incense and as an anti-influenza drug by Tibetans in China. Here, we collected W. glabra from the Gangs Rinpoche mountain at an altitude of 5200 m, and analyzed its essential oil by gas chromatography-mass spectrometry (GC-MS) combined with the retention indices (RI). Twenty-seven compounds, representing 72.4% of the total essential oil, were identified, including α-bisabolol (20.2%), valeranone (11.8%), chamazulene (9.9%), spathulenol (8.2%), β-caryophyllene (6.1%), and caryophyllene oxide (5.2%). Bioactivity evaluation of the essential oil revealed that it exhibited potent anti-influenza effect on viruses H3N2 and anti-inflammatory effect by inhibiting the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages, but no anti-complementary activity.
College of Science, Tibet University, Lhasa 8500, Tibet, China. 12110700018@fudan.edu.cn.
Ji
J
De
School of Pharmacy, Fudan University, Shanghai 201203, China. luyan@fudan.edu.cn.
Yan
Y
Lu
School of Pharmacy, Fudan University, Shanghai 201203, China. 13111030032@fudan.edu.cn.
Lijun
L
Ling
School of Life Science, Fudan University, Shanghai 200438, China. nanpeng@fudan.edu.cn.
Nan
N
Peng
School of Life Science, Fudan University, Shanghai 200438, China. yangzhong@fudan.edu.cn.
Yang
Y
Zhong
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects; D008070:Lipopolysaccharides / Q000009:adverse effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology; D010938:Plant Oils / Q000737:chemistry* / Q000494:pharmacology; D000067996:RAW 264.7 Cells; D018609:Tibet
D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D008070:Lipopolysaccharides; D009822:Oils, Volatile; D010938:Plant Oils; D009569:Nitric Oxide
Tibetan medicine; Waldheimia glabra; anti-inflammatory; anti-influenza; essential oil