Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent.
Gd3+-based contrast agents (CAs) are the most prevailing and widely used for enhanced magnetic resonance imaging (MRI). Numbers of approaches have been developed to regulate the key parameters in order to obtain high-relaxivity CAs, according to the classic Solomon-Bloembergen-Morgen theory. Herein, a method of controlling oxygen vacancies in inorganic nanosized CAs has been developed for largely accelerated proton relaxation to obtain a high r1value. Such a strategy is verified on oxygen-deficient PEG-NaxGdWO3nanorods, which exhibit a remarkable r1value up to 80 mM-1s-1(at 0.7 T) and a high r1value of 32.1 mM-1s-1on a clinical 3.0 T scanner, offering an excellent blood pool MRI performance at a low dose. Meanwhile, free electrons and/or oxygen-vacancy-induced small polarons can endow PEG-NaxGdWO3nanorods with significant photothermal conversion for MRI-guided photothermal therapy.
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.|University of Chinese Academy of Science , Beijing 100049, China.|Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University , Shanghai 200062, China.
Dalong
D
Ni
Department of Radiology, Huashan Hospital, Fudan University , Shanghai 200040, China.
Jiawen
J
Zhang
Department of Radiology, Huashan Hospital, Fudan University , Shanghai 200040, China.
Jing
J
Wang
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
Ping
P
Hu
Department of Radiology, Huashan Hospital, Fudan University , Shanghai 200040, China.
Yingying
Y
Jin
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.|University of Chinese Academy of Science , Beijing 100049, China.
Zhongmin
Z
Tang
Department of Radiology, Huashan Hospital, Fudan University , Shanghai 200040, China.
Zhenwei
Z
Yao
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.|Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University , Shanghai 200062, China.
Wenbo
0000-0001-6664-3453
W
Bu
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
Jianlin
0000-0001-8790-195X
J
Shi
magnetic resonance imaging; oxygen vacancy; photothermal therapy; theranostic agent; tungsten bronzes