Hypertension and breast cancer risk: a systematic review and meta-analysis.
Observational studies examining the relationship between hypertension and breast cancer risk have reported conflicting findings. We conducted this systematic review and meta-analysis to summarize the evidence regarding the association between hypertension and risk of breast cancer. Eligible studies were identified through a comprehensive literature search of PubMed, EMBASE, and the Cochrane library until August 2016. We included observational studies that reported relative risks (RR) with corresponding 95% confidence intervals (CIs). Results from individual studies were pooled by using a random-effects model. 29 articles of 30 studies, with totally 11643 cases of breast cancer, were eligible for inclusion in the meta-analysis. We observed a statistically significant association between hypertension and increased breast cancer risk (RR: 1.15; 95% CI: 1.08, 1.22). In the subgroup analysis, we found a positive association between hypertension and breast cancer incidence among postmenopausal women (RR: 1.20; 95% CI: 1.09, 1.31). In contrast, hypertension was not associated with risk of breast cancer among premenopausal women (RR: 0.97; 95% CI: 0.84, 1.12) and Asian population (RR: 1.07; 95% CI: 0.94, 1.22).This meta-analysis collectively suggests a significantly association between hypertension and breast cancer risk, specifically for postmenopausal hypertensive women.
Department of Health Statistics, Second Military Medical University, Shanghai 200433, China.
Hedong
H
Han
Department of Health Statistics, Second Military Medical University, Shanghai 200433, China.
Wei
W
Guo
Department of Health Statistics, Second Military Medical University, Shanghai 200433, China.
Wentao
W
Shi
Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Yamei
Y
Yu
Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Yunshuo
Y
Zhang
Department of Health Statistics, Second Military Medical University, Shanghai 200433, China.
Xiaofei
X
Ye
Department of Health Statistics, Second Military Medical University, Shanghai 200433, China.
Jia
J
He
D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology*; D016017:Odds Ratio; D017594:Publication Bias; D018570:Risk Assessment; D012307:Risk Factors