Quantum-chemical, NMR, FT IR, and ESI MS studies of complexes of colchicine with Zn(II).
Colchicine is a tropolone alkaloid from Colchicinum autumnale. It shows antifibrotic, antimitotic, and anti-inflammatory activities, and is used to treat gout and Mediterranean fever. In this work, complexes of colchicine with zinc(II) nitrate were synthesized and investigated using DFT,1H and13C NMR, FT IR, and ESI MS. The counterpoise-corrected and uncorrected interaction energies of these complexes were calculated. We also calculated their1H,13C NMR, and IR spectra and compared them with the corresponding experimentally obtained data. According to the ESI MS mass spectra, colchicine forms stable complexes with zinc(II) nitrate that have various stoichiometries: 2:1, 1:1:1, and 2:1:1 with respect to colchichine, Zn(II), and nitrate ion. All of the complexes were investigated using the quantum theory of atoms in molecules (QTAIM). The calculated and the measured spectra showed differences before and after the complexation process. Calculated electron densities and bond critical points indicated the presence of bonds between the ligands and the central cation in the investigated complexes that satisfied the quantum theory of atoms in molecules. Graphical Abstract DFT, NMR, FT IR, ESI MS, QTAIM and puckering studies of complexes of colchicine with Zn(II).
Faculty of Chemistry, Adam Mickiewicz University in Poznan, ul. Umultowska 89b, 61-614, Poznań, Poland. wojciech.jankowski89@gmail.com.
Wojciech
http://orcid.org/0000-0003-2058-6945
W
Jankowski
Faculty of Chemistry, Adam Mickiewicz University in Poznan, ul. Umultowska 89b, 61-614, Poznań, Poland.
Joanna
J
Kurek
Faculty of Chemistry, Adam Mickiewicz University in Poznan, ul. Umultowska 89b, 61-614, Poznań, Poland.
Piotr
P
Barczyński
Faculty of Chemistry, Adam Mickiewicz University in Poznan, ul. Umultowska 89b, 61-614, Poznań, Poland.
Marcin
M
Hoffmann
Colchicine; Complexes of colchicine with metal cations; DFT; ESI MS; FT IR; NMR; Quantum chemical calculations