Cytomegalovirus pneumonitis complicated by a central peribronchial pattern of organising pneumonia.
We present five cases of cytomegalovirus (CMV) pneumonitis occurring in patients after recent T cell deplete allogeneic stem cell transplantation (AlloHSCT). These cases were complicated by an organising pneumonia (during the recovery period) with a predominantly central peribronchial pattern. All patients presented with evidence of active CMV pneumonitis which was treated successfully with anti-viral therapy but was followed by persistent severe dyspnoea, cough and hypoxia. High resolution computed tomography (HRCT) imaging showed widespread central peribronchial consolidation with traction bronchiectasis. There was a marked clinical and physiological improvement after treatment with systemic corticosteroids. However, in all patients the lung function remained abnormal and in some cases imaging revealed a fibrosing lung disease. These cases represent a previously undescribed central peribronchial pattern of organising pneumonia complicating CMV pneumonitis that can result in chronic lung damage.
Clinical Haematology, University College Hospital, 235 Euston Road, London, NW1 2BU, United Kingdom.
Maria M
MM
Cuadrado
Imaging Department, University College Hospital, 235 Euston Road, London, NW1 2BU, United Kingdom.
Asia
A
Ahmed
Clinical Haematology, University College Hospital, 235 Euston Road, London, NW1 2BU, United Kingdom.
Ben
B
Carpenter
Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London, WC1E 6JJ, United Kingdom.
Jeremy S
JS
Brown
Allogeneic stem cells transplantation (AlloHSCT); Cytomegalovirus pneumonitis; Organising pneumonia