Plasma proANP1-98levels are positively associated with central obesity: A cross-sectional study in a general population of China.
BACKGROUND
Atrial natriuretic peptide (ANP) and its prohormone activating enzyme are associated with central obesity, suggesting there may be a potential relationship between proANP1-98and central obesity. However, the association is still lack of population-based evidence. We explored the association in a general population of China.


METHODS
We measured plasma proANP1-98, waist circumference and other traditional biomarkers in 2203 participants aged≥30y. Multivariate logistic regression models were used to determine the association between plasma proANP1-98and central obesity, and odds ratio (OR) and 95% confidence interval (CI) were calculated.


RESULTS
High proANP1-98was significantly associated with increased risk of central obesity in participants, and the multivariate adjusted OR (95% CI) of central obesity associated with the second, third and fourth quartiles of proANP1-98were 1.33 (1.03-1.72), 1.69 (1.31-2.19) and 1.76 (1.35-2.29), respectively, compared with the lowest quartile of proANP1-98. There was a dose-response relationship between proANP1-98and risk of central obesity among the participants (Ptrend<0.001). Sensitivity analyses further confirmed these associations. Adding proANP1-98to a model containing conventional risk factors improved discriminatory power of central obesity (as shown by significant improvement in continuous NRI and IDI).


CONCLUSIONS
Contrary to known reduced ANP levels in central obesity, we found that plasma proANP1-98was positively associated with central obesity, suggesting that elevated plasma proANP1-98may be a marker or a risk factor for central obesity.
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.
Zhengbao
Z
Zhu
Center for Disease Prevention and Control of Gusu District, Suzhou, China.
Qiu
Q
Zhang
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.
Hao
H
Peng
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.
Chongke
C
Zhong
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.
Yan
Y
Liu
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.
Xinfeng
X
Huangfu
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.
Yunfan
Y
Tian
Center for Disease Prevention and Control of Gusu District, Suzhou, China.
Xiangqin
X
Chao
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.
Aili
A
Wang
Center for Disease Prevention and Control of Gusu District, Suzhou, China.
Jianhua
J
Jin
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.. Electronic address: yhzhang@suda.edu.cn.
Yonghong
Y
Zhang
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D056128:Obesity, Abdominal / Q000097:blood* / Q000453:epidemiology*; D055105:Waist Circumference
D015415:Biomarkers; D009320:Atrial Natriuretic Factor
Central obesity; Chinese; Cross-sectional study; Plasma proANP; Waist circumference