The impact of the Psychoactive Substances Act 2016 on the online availability of MDMB-CHMICA.
BACKGROUND
In May 2016, the UK Government enacted the Psychoactive Substances Act which made it an offense to produce or supply many drugs including new psychoactive substances (NPS).


OBJECTIVE
We aimed to assess the impact of the Act on the availability of the synthetic cannabinoid receptor agonist methyl 2-[[1-(cyclohexylmethyl)indole-3-carbonyl]amino]-3,3-dimethylbutanoate (MDMB-CHMICA) from internet-based suppliers.


METHODS
Internet snapshot availability study.


METHODS
We conducted two snapshot availability surveys looking at the number of websites offering to sell MDMB-CHMICA: the first in March prior to implementation of the Act and the second in June, 1 month post-implementation.


RESULTS
In March and June 2016, we identified 47 and 38 websites, respectively, which offered to sell MDMB-CHMICA. There were no significant differences in the price of the drug nor the forms available for purchase. In the June survey there was a significant decrease in the number of websites which openly stated they were based in the UK (from 14 down to 2), three websites stated that they did not supply customers based in the UK and two websites stated they had ceased sales of MDMB-CHMICA due to the Act.


CONCLUSIONS
This study showed a small but limited reduction in the availability of MDMB-CHMICA from internet-based suppliers following implementation of the Act.
Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, London, UK.|Emergency Department, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, London, UK.
M
M
Haden
Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, London, UK.|Faculty of Life Sciences and Medicine, King's College London, London, UK.
D M
DM
Wood
Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, London, UK.|Faculty of Life Sciences and Medicine, King's College London, London, UK.
P I
PI
Dargan
D006801:Humans; D007211:Indoles / Q000191:economics* / Q000600:supply & distribution*; D020407:Internet; D007880:Legislation, Drug; D011619:Psychotropic Drugs / Q000600:supply & distribution*; D006113:United Kingdom
D007211:Indoles; D011619:Psychotropic Drugs; C000610109:methyl 2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate