Kaposi's sarcoma in an HIV-negative patient.
We report an HIV-negative, 55-year-old manwith recurrent Kaposi's sarcoma (KS) of the lowerextremities, who does not fit into any of thefour previously described variants of KS: classicKS, AIDS-related KS, iatrogenic KS, and AfricanendemicKS. There are reports in the literature ofchildhood-onset KS, which is thought to be dueto an inherited immune deficiency that confers ahigher susceptibility to human Herpesvirus-8 (HHV-8), which is the virus that is known to cause KS. Ourpatient may be affected with an inherited immunedeficiency that has predisposed him to KS, and thismutation also may account for his prostate andbladder cancer.
Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.
Shields
S
Callahan
Randie H
RH
Kim
Nooshin
N
Brinster
Jo-Ann
JA
Latkowski
D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D011471:Prostatic Neoplasms / Q000150:complications / Q000601:surgery; D011878:Radiotherapy; D012514:Sarcoma, Kaposi / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000601:surgery
D000970:Antineoplastic Agents