Computational models of O-LM cells are recruited by low or high theta frequency inputs depending on h-channel distributions.
Although biophysical details of inhibitory neurons are becoming known, it is challenging to map these details onto function. Oriens-lacunosum/moleculare (O-LM) cells are inhibitory cells in the hippocampus that gate information flow, firing while phase-locked to theta rhythms. We build on our existing computational model database of O-LM cells to link model with function. We place our models in high-conductance states and modulate inhibitory inputs at a wide range of frequencies. We find preferred spiking recruitment of models at high (4-9 Hz) or low (2-5 Hz) theta depending on, respectively, the presence or absence of h-channels on their dendrites. This also depends on slow delayed-rectifier potassium channels, and preferred theta ranges shift when h-channels are potentiated by cyclic AMP. Our results suggest that O-LM cells can be differentially recruited by frequency-modulated inputs depending on specific channel types and distributions. This work exposes a strategy for understanding how biophysical characteristics contribute to function.
Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.|Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Vladislav
0000-0001-5000-389X
V
Sekulić
Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.|Departments of Medicine (Neurology) and Physiology, University of Toronto, Toronto, Ontario, Canada.
Frances K
0000-0001-7819-4202
FK
Skinner
D000200:Action Potentials; D000818:Animals; D003198:Computer Simulation; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D008959:Models, Neurological; D013826:Theta Rhythm
computational neuroscience; hippocampus interneuron; mouse; multi-compartment model; neuroscience