[Research progress on forkhead box protein O1 and bone metabolism].
Recent studies found that forkhead box protein O1 (FoxO1) does not only demonstrate important biological functions in cell proliferation, gluconeogenesis, energy metabolism, and oxidative stress, but it also plays a vital role in the remodeling process of bones. FoxO1 can regulate bone mass by affecting osteoblasts, osteoclasts, and precursor cells. In this article, we review the role of FoxO1 in bone metabolism and elucidate its underlying mechanism.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Shu
S
Linjing
State Key Laboratory of Oral Diseases, Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Wu
W
Yingying
State Key Laboratory of Oral Diseases, Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Tan
T
Zhen
State Key Laboratory of Oral Diseases, Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Gong
G
Ping
D001842:Bone and Bones / Q000378:metabolism*; D049109:Cell Proliferation; D000071161:Forkhead Box Protein O1; D006801:Humans; D010006:Osteoblasts; D010010:Osteoclasts
D000071161:Forkhead Box Protein O1
bone metabolism; forkhead box protein O1; osteoblasts; osteoclasts