[Advances in effects of integrin-linked kinase on cutaneous wound healing and the relative mechanism].
Previous studies have demonstrated that integrin-linked kinases (ILKs) are abundantly expressed in extracellular matrix (ECM) riche dermis, hair follicles, and basal cells of epidermis. ILKs are not only essential for the maintenance of skin structure, but also play important roles in wound healing. ILKs can promote the formation of granulation tissue by stimulating the proliferation of fibroblasts and secretion of ECM, accelerate wound contraction by inducing the differentiation of fibroblasts to myofibroblasts, and boost reepithelization by promoting proliferation, migration, and differentiation of keratinocytes and follicle epidermal stem cells.
Department of Burns and Plastic Surgery, Guangzhou Red Cross Hospital, Ji'nan University, Guangzhou 510220, China.
R X
RX
Zhou
Y Y
YY
Li
W H
WH
Lin
G
G
Li
J E
JE
Sun
W B
WB
Zhou
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002454:Cell Differentiation; D002465:Cell Movement; D020405:Dermis / Q000502:physiology; D004817:Epidermis; D004847:Epithelial Cells / Q000502:physiology; D005109:Extracellular Matrix; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D015603:Keratinocytes / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D013234:Stem Cells / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology*; D000099200:Scaffold Protein ILK
D016023:Integrins; D017346:Protein Serine-Threonine Kinases; D000099200:Scaffold Protein ILK
Integrin-linked kinase; Mechanism; Skin; Wound healing; Wounds and injuries