Glycogen-Rich Clear Cell Squamous Cell Carcinoma Originating in the Oral Cavity.
Clear cell squamous cell carcinoma (CCSCC) is a rare histological subtype of squamous cell carcinoma (SCC) that was originally described in the skin. Here, we report a case of a 66-year-old female patient who presented with a fungating ulcerative mass of the left lateral tongue extending anteriorly to the floor of the mouth, and posteriorly to the left retromolar fossa and the oropharynx. The patient had a history of SCC of the left posterior tongue that was treated with partial glossectomy and adjuvant radiotherapy. Representative biopsies were obtained from the floor of the mouth, tongue and retromolar fossa. The examined biopsies showed various degrees of dysplastic surface epithelium with transition into infiltrating epithelial tumor nests and cords with clear cytoplasm and malignant cellular features. Pancytokeratin, CK5/6, and p63 were all diffusely positive. S-100, Calponin, and smooth muscle actin (SMA) were negative. PAS stain was diffusely positive and diastase labile in the tumor clear cells. Sparse areas of mucicarmine positivity were noted. Based on these findings a final diagnosis of a glycogen-rich CCSCC was given. This case represents a very rare histological variant of oral SCC, which is significant for the histological differential diagnosis of clear cell tumors of the oral cavity.
Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, 650 West Baltimore Street, 7th Floor North, Baltimore, MD, 21201, USA. khouryzh@umaryland.edu.
Zaid H
ZH
Khoury
Department of Diagnostic Sciences, School of Dental Medicine, Tufts University, Boston, MA, 02111, USA.|Department of Biomedical Dental Science, Dental College, Dammam University, Dammam, Saudi Arabia.
Amr
A
Bugshan
Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, 21201, USA.
Joshua E
JE
Lubek
Department of Pathology, School of Medicine, University of Maryland Baltimore, Baltimore, MD, 21201, USA.
John C
JC
Papadimitriou
Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, 650 West Baltimore Street, 7th Floor North, Baltimore, MD, 21201, USA.
John R
JR
Basile
Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, 650 West Baltimore Street, 7th Floor North, Baltimore, MD, 21201, USA.
Rania H
RH
Younis
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006003:Glycogen / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology; D000077195:Squamous Cell Carcinoma of Head and Neck
D006003:Glycogen
Clear cell; Glycogen; Oral cavity; Prognosis; Squamous cell carcinoma