Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Mice.
Sigma-1 receptor (Sig-1R) is molecular chaperone regulating calcium efflux from the neuronal endoplasmic reticulum to mitochondria. Recent studies show that Sig-1R stimulation antagonizes depressive-like behaviors in animal models, but molecular mechanisms underlying this effect remain unclear. Here, we focus on the effects of Sig-1R ligands on hippocampal neurogenesis and depressive-like behaviors. Sig-1R stimulation also enhances CaMKII /CaMKIV and protein kinase B (Akt) activities in hippocampus. Therefore, we discuss the fundamental roles of Sig-1R, CaMKII /CaMKIV and protein kinase B (Akt) signaling in amelioration of depressive-like behaviors following Sig-1R stimulation.
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan. kfukunaga@m.tohoku.ac.jp.
Kohji
K
Fukunaga
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Shigeki
S
Moriguchi
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism; D003863:Depression / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008024:Ligands; D051379:Mice; D055495:Neurogenesis / Q000502:physiology*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D017480:Receptors, sigma / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D000097605:Sigma-1 Receptor
D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D008024:Ligands; D051057:Proto-Oncogene Proteins c-akt; D017480:Receptors, sigma; D000097605:Sigma-1 Receptor
BDNF; CaMKII; CaMKIV; Depression; Neurogenesis; Sigma-1 receptor