Pathogenesis of meningococcal purpura fulminans.
Purpura fulminans (PF) is a dreadful and frequent complication of Neisseria meningitidis invasive infection, and is associated with a high mortality rate. This syndrome begins with dermal microvessels thrombosis that rapidly lead to hemorrhagic skin necrosis. In this review, we discuss the prothrombotic events occurring during meningococcal infection. Moreover, recent data from an experimental mouse model have highlighted the critical role of the meningococcus adhesion to the endothelium in the development of PF lesions, thus opening new therapeutic perspectives.
Institut Necker Enfants Malades, 75993 Paris, France.|Université Paris Descartes, 75993, Paris, France.|INSERM U1151, 75993 Paris, France.|CNRS UMR8253, 75993 Paris, France.|Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Necker Enfants Malades, Service de Microbiologie Clinique, 75743 Paris, France.
Hervé
H
Lécuyer
INSERM UMR-S1176, Université Paris-Sud, Université Paris Saclay, 94276 Le Kremlin-Bicêtre, France.|Assistance Publique - Hôpitaux de Paris, Hôpital Universitaire Necker Enfants Malades, Service d'Hématologie Biologique, 75743 Paris, France.
Delphine
D
Borgel
Institut Necker Enfants Malades, 75993 Paris, France.|Université Paris Descartes, 75993, Paris, France.|INSERM U1151, 75993 Paris, France.|CNRS UMR8253, 75993 Paris, France.|Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Necker Enfants Malades, Service de Microbiologie Clinique, 75743 Paris, France.
Xavier
X
Nassif
Institut Necker Enfants Malades, 75993 Paris, France.|Université Paris Descartes, 75993, Paris, France.|INSERM U1151, 75993 Paris, France.|CNRS UMR8253, 75993 Paris, France.
Mathieu
M
Coureuil
D001777:Blood Coagulation; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D008589:Meningococcal Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology*; D009345:Neisseria meningitidis / Q000276:immunology; D055665:Purpura Fulminans / Q000097:blood / Q000209:etiology*
Neisseria meningitidis; coagulation; purpura fulminans