Keeping the customers stratified: moving toward genetics-based treatment options in childhood NS.
In this issue, Bierzynska et al. report the results of analyzing a cohort of children with steroid-resistant nephrotic syndrome (SRNS) of childhood, correlating genetic studies with clinical outcomes. This approach has the potential to advance both our research into the causes and treatments of childhood SRNS and our ability to stratify patients into groups that are likely to be responsive to specific treatments. Here, we discuss some of the strengths and limitations of this report.
Department of Pharmacology and Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Megan
M
Puckelwartz
Division of Kidney Diseases, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address: schnaper@northwestern.edu.
H William
HW
Schnaper
D015331:Cohort Studies; D006801:Humans; D009404:Nephrotic Syndrome