Multiple mucocutaneous ulcers associated with cocaine-induced midline destructive lesions.
Cocaine-induced midline destructive lesions (CIMDL) occur in a small subset of cocaine users, who clinically present with inflammation and necrosis of facial midline structures such as the palate, nasal septum, turbinates, and sinuses. We present a patient with CIMDL occurring concomitantly with ulcers on the cheek and upper trunk. Multiple biopsy specimens from the cutaneous and mucosal lesions consistently showed a dense dermal/submucosal infiltrate of neutrophils and plasma cells, without vasculitis or thrombosis. The ulcers resolved following cessation of cocaine use.
Brittany
B
Blaise
Lucinda
L
Buescher
Division of Dermatology, Southern Illinois University School of Medicine, Springfield. mwilson3@siumed.edu.
Morgan L
ML
Wilson
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D019970:Cocaine-Related Disorders / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D061270:Nasal Septal Perforation / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology / Q000473:pathology; D019226:Oral Ulcer / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology / Q000473:pathology; D021362:Palate, Hard; D012883:Skin Ulcer / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology / Q000473:pathology
D019268:Antibodies, Antineutrophil Cytoplasmic