Hollow hyaluronic acid particles by competition between adhesive and cohesive properties of catechol for anticancer drug carrier.
The marine mussel-inspired properties of catechol, adhesiveness and cohesiveness, have been applied with pH control to fabricate hollow particles using a silica core and catechol-modified hyaluronic acid (HA-CA) shell for an anticancer drug carrier. The competition between adhesive and cohesive properties of catechol with different pH values leads to various structures, a rough catechol modified HA (HA-CA) shell at pH 5.5, monodisperse spherical silica@HA-CA particles at pH 7.4, and an amorphous HA-CA layer at pH 8.5. The redox transition of catechol with pH is a key factor modulating the behavior of the HA-CA shell on the silica core, which induces strong adhesion of HA-CA to silica at pH 5.5 and structural hardness with cohesive coupling at pH 7.4. In addition, after core removal, the hollow HA-CA particles are followed by loading of anticancer drug, doxorubicin (DOX). DOX loaded HA-CA particles show pH-triggered release behavior and dramatic cytotoxic effect indicating that they are a promising novel anticancer drug carrier.
Department of Chemistry and Research Institute for Convergence of Basic Science, Hanyang University, Seoul 133-791, Republic of Korea. Electronic address: ljw5081@naver.com.
Jeongwook
J
Lee
Department of Life Science, Research Institute for Nature Sciences, Hanyang University, Seoul 133-791, Republic of Korea. Electronic address: vanity0706@gmail.com.
Ki Chun
KC
Yoo
Department of Chemistry and Research Institute for Convergence of Basic Science, Hanyang University, Seoul 133-791, Republic of Korea. Electronic address: abmartt@gmail.com.
Jaehyoung
J
Ko
Department of Chemistry and Research Institute for Convergence of Basic Science, Hanyang University, Seoul 133-791, Republic of Korea. Electronic address: ybw0110@nate.com.
Bowon
B
Yoo
Department of Chemistry and Research Institute for Convergence of Basic Science, Hanyang University, Seoul 133-791, Republic of Korea. Electronic address: joohwees@hanyang.ac.kr.
Joohuei
J
Shin
Department of Life Science, Research Institute for Nature Sciences, Hanyang University, Seoul 133-791, Republic of Korea. Electronic address: sj0420@hanyang.ac.kr.
Su-Jae
SJ
Lee
Department of Chemistry and Research Institute for Convergence of Basic Science, Hanyang University, Seoul 133-791, Republic of Korea. Electronic address: dsohn@hanyang.ac.kr.
Daewon
D
Sohn
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002396:Catechols / Q000737:chemistry*; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D012822:Silicon Dioxide
D000970:Antineoplastic Agents; D002396:Catechols; D004337:Drug Carriers; D012822:Silicon Dioxide; D004317:Doxorubicin; D006820:Hyaluronic Acid
Adhesive; Catechol; Hyaluronic acid; Redox transition; pH triggered release