Age at injury is associated with the long-term cognitive outcome of traumatic brain injuries.
BACKGROUND
The association between age at injury (AAI) and long-term cognitive outcome of traumatic brain injuries (TBI) is debatable.


METHODS
Eligible participants with a history of TBI from Alzheimer's Disease Neuroimaging Initiative were divided into a childhood TBI (cTBI) group (the AAI ≤ 21 years old) and an adult TBI (aTBI) group (the AAI > 21 years old).


RESULTS
The cTBI group has a higher Everyday Cognition total score than the aTBI group. All perceived cognitive functions are worse for the cTBI group than for the aTBI group except memory. By contrast, the cTBI group has higher assessment scores on either the Boston Naming Test or Rey Auditory Verbal Learning Test than the aTBI group.


CONCLUSIONS
The AAI is associated with the long-term cognitive outcomes in older adults with a history of TBI.
Master of Physician Assistant Studies, School of Health & Rehabilitation Sciences, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
Wei
W
Li
Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Shannon L
SL
Risacher
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Thomas W
TW
McAllister
Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Andrew J
AJ
Saykin
Alzheimer's disease; Dementia; Executive function; TBI