Eu, Gd-Codoped Yttria Nanoprobes for Optical and T₁-Weighted Magnetic Resonance Imaging.
Nanoprobes with multimodal functionality have attracted significant interest recently because of their potential applications in nanomedicine. This paper reports the successful development of lanthanide-doped Y₂O₃ nanoprobes for potential applications in optical and magnetic resonance (MR) imaging. The morphology, structural, and optical properties of these nanoprobes were characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), and photoluminescence (PL). The cytotoxicity test showed that the prepared lanthanide-doped Y₂O₃ nanoprobes have good biocompatibility. The obvious contrast enhancement in the T₁-weighted MR images suggested that these nanoprobes can be used as a positive contrast agent in MRI. In addition, the clear fluorescence images of the L-929 cells incubated with the nanoprobes highlight their potential for optical imaging. Overall, these results suggest that prepared lanthanide-doped Y₂O₃ nanoprobes can be used for simultaneous optical and MR imaging.
Department of Physics and Astronomy, Seoul National University, Seoul 08826, Korea. timuratabaev@yahoo.com.
Timur Sh
TS
Atabaev
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Korea. pignunssob@naver.com.
Jong Ho
JH
Lee
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, Korea. choel15@naver.com.
Yong Cheol
YC
Shin
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, Korea. nanohan@pusan.ac.kr.
Dong-Wook
DW
Han
Department of Radiology, Pusan National University Yangsan Hospital, Yangsan 50612, Korea. kschoo0618@naver.com.
Ki Seok
KS
Choo
Department of Radiology, Pusan National University Yangsan Hospital, Yangsan 50612, Korea. junwb73@hanmail.net.
Ung Bae
UB
Jeon
Department of Radiology, Pusan National University Yangsan Hospital, Yangsan 50612, Korea. yhwang79@gmail.com.
Jae Yeon
JY
Hwang
Department of Radiology, Pusan National University Yangsan Hospital, Yangsan 50612, Korea. sigmajeonga@hanmail.net.
Jeong A
JA
Yeom
Department of Nano Energy Engineering, Pusan National University, Miryang 50463, Korea. hkkim@pusan.ac.kr.
Hyung-Kook
HK
Kim
Department of Nano Energy Engineering, Pusan National University, Miryang 50463, Korea. yhwang@pusan.ac.kr.
Yoon-Hwae
YH
Hwang
T1-weighted contrast agent; cytotoxicity; magnetic resonance imaging; nanoprobes; optical imaging; yttria