[Ghrelin: a gastric hormone at the crossroad between growth and appetite regulation].
Ghrelin is a 28 amino acid peptide hormone synthesized within the gastrointestinal tract. Initially identified as the endogenous ligand of the GHS-R1a (Growth Hormone Secretagogue Receptor 1a), ghrelin is a powerful stimulator of growth hormone (GH) secretion. At the crossroad between nutrition, growth and long-term energy metabolism, ghrelin also plays a unique role as the first identified gastric hormone increasing appetite and adiposity. However, the role of the ghrelin/GHS-R system in the physiology of growth, feeding behaviour and energy homeostasis needs to be better understood. Utilization of pharmacological tools and complementary animal models with deficiency in preproghrelin, ghrelin-O-acyl-transferase (GOAT - the enzyme that acylates ghrelin -) or GHS-R in situations of chronic undernutrition or high fat diet gives a more precise overview of the role of ghrelin in the pathophysiology of eating and metabolic disorders.
Alexandra
A
Labarthe
Virginie
V
Tolle
D000818:Animals; D001069:Appetite Regulation / Q000235:genetics; D004734:Energy Metabolism / Q000235:genetics; D001068:Feeding and Eating Disorders / Q000235:genetics / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000502:physiology; D054439:Ghrelin / Q000378:metabolism / Q000502:physiology*; D048788:Growth and Development / Q000235:genetics; D006801:Humans; D008659:Metabolic Diseases / Q000235:genetics / Q000378:metabolism
D005768:Gastrointestinal Hormones; D054439:Ghrelin