Methotrexate-Induced Neurotoxicity in Hispanic Adolescents with High-Risk Acute Leukemia-A Case Series.
Intrathecal methotrexate (IT MTX) and high-dose intravenous methotrexate (HD MTX) are important components of treatment in high-risk acute leukemia. We describe five Hispanic adolescents with high-risk acute leukemia at our institution who experienced MTX-induced neurotoxicity. All patients were eventually rechallenged with MTX. Two of the five patients had a second episode of neurotoxicity, but all patients recovered. Further studies should be performed to determine whether Hispanic patients are more susceptible to MTX neurotoxicity.
1 Department of Pediatrics, Cook County Health and Hospitals System , Chicago, Illinois.
Lisa
L
Giordano
1 Department of Pediatrics, Cook County Health and Hospitals System , Chicago, Illinois.
Oyinade
O
Akinyede
2 Department of Pediatrics, University of Illinois Hospital and Health Sciences System , Chicago, Illinois.
Nidhi
N
Bhatt
1 Department of Pediatrics, Cook County Health and Hospitals System , Chicago, Illinois.
Dipti
D
Dighe
1 Department of Pediatrics, Cook County Health and Hospitals System , Chicago, Illinois.
Asneha
A
Iqbal
D000208:Acute Disease; D000293:Adolescent; D017668:Age of Onset; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015331:Cohort Studies; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D007938:Leukemia / Q000188:drug therapy* / Q000453:epidemiology*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D020258:Neurotoxicity Syndromes / Q000453:epidemiology*; D012307:Risk Factors; D055815:Young Adult
D008727:Methotrexate
Hispanic; acute leukemia; methotrexate; neurotoxicity