Strategies to Target Glucose Metabolism in Tumor Microenvironment on Cancer by Flavonoids.
The imbalance between glucose metabolism and cancer cell growth in tumor microenvironment (TME), which are closely related with the occurrence and progression of cancer. Accumulating evidence has demonstrated that flavonoids exert many biological properties, including antioxidant and anticarcinogenic activities. Recently, the roles and applications of flavonoids, particularly in relation to glucose metabolism in cancers, have been highlighted. Thus, the identification of flavonoids targeting alternative glucose metabolism pathways in TME may represent an attractive approach to the more effective therapeutic strategies for cancer. In this review, we will focus on the roles of flavonoids in regulating glucose metabolism and cancer cell growth in TME, such as proliferation advantage, cell mobility, and chemoresistance to cancer, as well as modifiers of thermal sensitivity. Not only have such large-scale endeavors been useful in providing fundamental insights into natural and synthesized flavonoids that can prevent and treat cancer, but also have led to the discovery of potential targets for cancer therapy.
a Department of Pharmaceutics , Jiangsu University , Shanghai , China.|b Hubei University of Medicine , Shiyan , China.
Gang
G
Wang
a Department of Pharmaceutics , Jiangsu University , Shanghai , China.|b Hubei University of Medicine , Shiyan , China.
Jun-Jie
JJ
Wang
b Hubei University of Medicine , Shiyan , China.
Rui
R
Guan
a Department of Pharmaceutics , Jiangsu University , Shanghai , China.
Li
L
Du
c Jiangsu University Health Science Center , Jiangsu , China.
Jing
J
Gao
c Jiangsu University Health Science Center , Jiangsu , China.
Xing-Li
XL
Fu
D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D005419:Flavonoids / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D051246:Glucose Transport Proteins, Facilitative / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D013963:Thyroid Hormones / Q000378:metabolism; D059016:Tumor Microenvironment / Q000187:drug effects*; D000097810:Thyroid Hormone-Binding Proteins
D002352:Carrier Proteins; D005419:Flavonoids; D005947:Glucose; D051246:Glucose Transport Proteins, Facilitative; D008565:Membrane Proteins; D013963:Thyroid Hormones; D000097810:Thyroid Hormone-Binding Proteins