Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers.
Amyloid-β (Aβ) oligomers are causative agents triggering AD pathogenesis, but their elimination remains challenging. We herein reported a natural cyclopeptide tyrocidine A prevents and reverses amyloidogenesis without Aβ oligomer accumulation by stabilizing the monomeric, but not the oligomeric state of Aβ peptides.
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhoubh5@mail.sysu.edu.cn phsbxzh@mail.sysu.edu.cn.
Gesi
G
Wen
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhoubh5@mail.sysu.edu.cn phsbxzh@mail.sysu.edu.cn.
Wenjing
W
Qin
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhoubh5@mail.sysu.edu.cn phsbxzh@mail.sysu.edu.cn.
Daoyuan
D
Chen
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhoubh5@mail.sysu.edu.cn phsbxzh@mail.sysu.edu.cn.
Youqiao
Y
Wang
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhoubh5@mail.sysu.edu.cn phsbxzh@mail.sysu.edu.cn.
Xin
X
Yue
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhoubh5@mail.sysu.edu.cn phsbxzh@mail.sysu.edu.cn.
Ziyi
Z
Liu
Department of Pharmacology, Xinhua College of Sun Yat-sen University, Guangzhou, P. R. China.
Yingnan
Y
Cao
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhoubh5@mail.sysu.edu.cn phsbxzh@mail.sysu.edu.cn.
Jun
J
Du
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhoubh5@mail.sysu.edu.cn phsbxzh@mail.sysu.edu.cn.
Binhua
B
Zhou
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhoubh5@mail.sysu.edu.cn phsbxzh@mail.sysu.edu.cn.
Xianzhang
http://orcid.org/0000-0002-3015-6634
X
Bu
D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008968:Molecular Conformation; D066329:Protein Aggregates / Q000187:drug effects; D055550:Protein Stability / Q000187:drug effects; D014440:Tyrocidine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*
D016229:Amyloid beta-Peptides; D066329:Protein Aggregates; D014440:Tyrocidine