How does the multifaceted plant hormone salicylic acid combat disease in plants and are similar mechanisms utilized in humans?
Salicylic acid (SA) is an important plant hormone that regulates many aspects of plant growth and development, as well as resistance to (a)biotic stress. Efforts to identify SA effector proteins have revealed that SA binds to and alters the activity of multiple plant proteins-this represents a shift from the paradigm that hormones mediate their functions via one or a few receptors. SA and its derivatives also have multiple targets in animals; some of these proteins, like their plant counterparts, are associated with pathological processes. Together, these findings suggest that SA exerts its defense-associated effects in both kingdoms via a large number of targets.
Boyce Thompson Institute, 533 Tower Rd, Ithaca, NY, 14853, USA.
D'Maris Amick
DA
Dempsey
Boyce Thompson Institute, 533 Tower Rd, Ithaca, NY, 14853, USA. dfk8@cornell.edu.
Daniel F
DF
Klessig
D000383:Agriculture; D001241:Aspirin / Q000494:pharmacology; D003600:Cytosol / Q000378:metabolism; D060467:Disease Resistance / Q000187:drug effects; D006801:Humans; D010935:Plant Diseases / Q000276:immunology / Q000517:prevention & control*; D010937:Plant Growth Regulators / Q000494:pharmacology*; D020156:Salicylic Acid / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects
D010937:Plant Growth Regulators; D020156:Salicylic Acid; D001241:Aspirin