Computational Psychiatry and the Challenge of Schizophrenia.
Schizophrenia research is plagued by enormous challenges in integrating and analyzing large datasets and difficulties developing formal theories related to the etiology, pathophysiology, and treatment of this disorder. Computational psychiatry provides a path to enhance analyses of these large and complex datasets and to promote the development and refinement of formal models for features of this disorder. This presentation introduces the reader to the notion of computational psychiatry and describes discovery-oriented and theory-driven applications to schizophrenia involving machine learning, reinforcement learning theory, and biophysically-informed neural circuit models.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.|Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.|Department of Neuroscience, Yale-New Hospital, New Haven, CT, USA.|VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA.
John H
JH
Krystal
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
John D
JD
Murray
Department of Psychology, Yale University, New Haven, CT, USA.|Department of Psychology, Spring Health, New York, NY, USA.
Adam M
AM
Chekroud
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.|Department of Psychology, Yale University, New Haven, CT, USA.
Philip R
PR
Corlett
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Genevieve
G
Yang
Center for Neural Science, NYU, New York, NY, USA.
Xiao-Jing
XJ
Wang
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Alan
A
Anticevic
D019295:Computational Biology / Q000379:methods*; D006801:Humans; D009488:Neurosciences / Q000379:methods*; D011570:Psychiatry / Q000379:methods*; D012559:Schizophrenia
computational neuroscience; computational psychiatry; delusions; machine learning; medication selection; schizophrenia; working memory