Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction.
A versatile continuous-flow synthesis of highly functionalized 1,2,4-oxadiazoles starting from carboxylic acids is reported. This process was applied to the multistep synthesis of imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazoles, using a three reactor, multistep continuous-flow system without isolation of intermediates. This continuous-flow method was successfully combined with a single-step liquid-liquid microextraction unit to remove high boiling point polar solvents and impurities and provides the target compounds in high purity with excellent overall yields.
Cancer Metabolism & Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Ananda
A
Herath
Cancer Metabolism & Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Nicholas D P
ND
Cosford
1,2,4-oxadiazole; imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazole; imidazo[1,2-a]pyridine; liquid–liquid extraction module; microreactor