Clinical Significance of Fibrinogen Degradation Product Among Traumatized Patients.
OBJECTIVE
We retrospectively analyzed trauma patients who were transported by a physician-staffed helicopter (doctor helicopter) to investigate the clinical significance of the fibrinogen degradation product (FDP) level on arrival.


METHODS
From February 2011 to July 2016, a medical chart review was retrospectively performed for all patients with trauma who were transported by the doctor helicopter. The subjects were divided into 2 groups: a survival group and a fatal group.


RESULTS
There were 135 patients in the survival group and 16 in the fatal group. The ratio of head injury, value of Injury Severity Score (ISS), and level of FDP in the fatal group were significantly greater than in the survival group. The average Glasgow Coma Scale and systolic blood pressure in the fatal group were significantly smaller than in the survival group. The FDP level at arrival was positively associated with the ISS (R = 0.74, P < .0001). After excluding subjects with shock, unconsciousness, and head injury, the FDP level was still positively associated with the ISS (R = 0.60, P < .0001).


CONCLUSIONS
Therefore, the FDP level may be a useful biochemical parameter for the initial evaluation of the severity of trauma, even in blunt trauma patients without head injury or with stable vital signs.
Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University, Shizouka, Japan.
Kouhei
K
Ishikawa
Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University, Shizouka, Japan.
Kazuhiko
K
Omori
Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University, Shizouka, Japan.
Kei
K
Jitsuiki
Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University, Shizouka, Japan.
Hiromichi
H
Ohsaka
Numazu City Hospital, Numazu, Japan.
Hiroshi
H
Ito
Numazu City Hospital, Numazu, Japan.
Katsuhito
K
Shimoyama
Numazu City Hospital, Numazu, Japan.
Toru
T
Fukunaga
Numazu City Hospital, Numazu, Japan.
Norikazu
N
Urabe
Numazu City Hospital, Numazu, Japan.
Souichirou
S
Kitamura
Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University, Shizouka, Japan. Electronic address: yyanaga@juntendo.ac.jp.
Youichi
Y
Yanagawa
D000328:Adult; D000368:Aged; D017732:Air Ambulances; D006259:Craniocerebral Trauma / Q000378:metabolism / Q000401:mortality; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D015600:Glasgow Coma Scale; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014187:Transportation of Patients; D014947:Wounds and Injuries / Q000378:metabolism* / Q000401:mortality; D014949:Wounds, Nonpenetrating / Q000378:metabolism / Q000401:mortality
D005338:Fibrin Fibrinogen Degradation Products