Motion management strategies and technical issues associated with stereotactic body radiotherapy of thoracic and upper abdominal tumors: A review from NRG oncology.
The efficacy of stereotactic body radiotherapy (SBRT) has been well demonstrated. However, it presents unique challenges for accurate planning and delivery especially in the lungs and upper abdomen where respiratory motion can be significantly confounding accurate targeting and avoidance of normal tissues. In this paper, we review the current literature on SBRT for lung and upper abdominal tumors with particular emphasis on addressing respiratory motion and its affects. We provide recommendations on strategies to manage motion for different, patient-specific situations. Some of the recommendations will potentially be adopted to guide clinical trial protocols.
Department of Radiation Oncology, University of Pittsburgh Cancer Institute and UPMC CancerCenter, Pittsburgh, PA, 15232, USA.
Edward D
ED
Brandner
Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA.
Indrin J
IJ
Chetty
Sidney Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Tawfik G
TG
Giaddui
Imaging and Radiation Oncology Core (IROC), University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ying
Y
Xiao
Department of Radiation Oncology, University of Pittsburgh Cancer Institute and UPMC CancerCenter, Pittsburgh, PA, 15232, USA.
M Saiful
MS
Huq
D000008:Abdominal Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008168:Lung; D008175:Lung Neoplasms / Q000532:radiotherapy*; D009038:Motion; D016634:Radiosurgery
4D; SBRT; abdomen; gating; lung; respiratory motion; stereotactic body radiotherapy