Drift diffusion model of reward and punishment learning in rare alpha-synuclein gene carriers.
To understand the cognitive effects of alpha-synuclein polymorphism, we employed a drift diffusion model (DDM) to analyze reward- and punishment-guided probabilistic learning task data of participants with the rare alpha-synuclein gene duplication and age- and education-matched controls. Overall, the DDM analysis showed that, relative to controls, asymptomatic alpha-synuclein gene duplication carriers had significantly increased learning from negative feedback, while they tended to show impaired learning from positive feedback. No significant differences were found in response caution, response bias, or motor/encoding time. We here discuss the implications of these computational findings to the understanding of the neural mechanism of alpha-synuclein gene duplication.
a School of Social Sciences and Psychology, Marcs Institute for Brain and Behaviour, Western Sydney University , Penrith , Australia.
Ahmed A
AA
Moustafa
b Nyírő Gyula Hospital, National Institute of Psychiatry and Addictions , Budapest , Hungary.|c Faculty of Medicine, Department of Physiology , University of Szeged , Szeged , Hungary.|d Department of Cognitive Science , Budapest University of Technology and Economics , Budapest , Hungary.
Szabolcs
S
Kéri
b Nyírő Gyula Hospital, National Institute of Psychiatry and Addictions , Budapest , Hungary.|d Department of Cognitive Science , Budapest University of Technology and Economics , Budapest , Hungary.
Bertalan
B
Polner
e Department of Psychology , Syracuse University, Syracuse , NY , USA.
Corey
C
White
D016022:Case-Control Studies; D019295:Computational Biology; D030141:Feedback, Psychological; D005260:Female; D020440:Gene Duplication; D006801:Humans; D007858:Learning; D008297:Male; D008875:Middle Aged; D008960:Models, Psychological; D010300:Parkinson Disease / Q000235:genetics* / Q000503:physiopathology; D011678:Punishment; D012201:Reward; D051844:alpha-Synuclein / Q000235:genetics*
D051844:alpha-Synuclein
Alpha-synuclein gene; Parkinson’s disease; drift diffusion model; punishment; reinforcement learning; reward