[Clinical efficacy of the fine needle aspiration of the cell block in the diagnosis of parotid gland masses].
OBJECTIVE
To investigate the clinical significance of cell blocks obtained by ultrasound-guided fine needle aspiration in diagnosing parotid gland masses.


METHODS
Cell blocks were made in 285 parotid gland masses by ultrasound-guided fine needle aspiration. Diagnosis was conducted using the cell blocks. Non-tumor masses were subjected to conservative treatment, and cysts and tumors were treated with surgery. The cell block sections from masses with the diagnosis of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) were applied to the detection of immunocytochemical staining for the stem cell factor receptor CD117.


RESULTS
The satisfaction rate of the specimen was 95.1% (271/285). The accuracy rate of the diagnosis was 94.5% (256/271), the sensitivity was 87.0% (67/77), and the specificity was 98.1% (157/160). The positive rate of CD117 in ACC was 95.2% (20/21), whereas that in PA was 20.3% (25/123). The positive rate of CD117 in ACC was higher than that in PA (P<0.01).


CONCLUSIONS
The use of cell blocks obtained from ultrasound-guided fine needle aspiration, together with molecular marker detection, has great significance in diagnosing parotid gland masses. .
Pharmaceutical Department, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
Chen
C
Hong
Dept. of Pathology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
Fang
F
Qingquan
Dept. of Pathology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
Tu
T
Jinhua
Dept. of Stomatology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
Cai
C
Qiaoling
Supersonic Phantom Branch, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
Zhang
Z
Suhua
D008949:Adenoma, Pleomorphic; D044963:Biopsy, Fine-Needle; D003528:Carcinoma, Adenoid Cystic; D003560:Cysts; D005260:Female; D006801:Humans; D008297:Male; D010306:Parotid Gland; D010307:Parotid Neoplasms; D010549:Personal Satisfaction; D013194:Staining and Labeling; D014465:Ultrasonics
cell block; fine needle aspiration; mass; molecular marker; parotid gland