Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology.
The incidence of pulmonary ground-glass opacity (GGO) lesions is increasing as a result of the widespread use of multislice spiral computed tomography (CT) and the low-dose CT screening for lung cancer detection. Besides benign lesions, GGOs can be a specific type of lung adenocarcinomas or their preinvasive lesions. Evaluation of pulmonary GGO and investigation of the correlation between CT imaging features and lung adenocarcinoma subtypes or driver genes can be helpful in confirming the diagnosis and in guiding the clinical management. Our review focuses on the pathologic characteristics of GGO detected at CT, involving histopathology and molecular pathology.
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Jian-Wei
JW
Gao
Department of Radiology, European Institute of Oncology, Milan, Italy.
Stefania
S
Rizzo
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Li-Hong
LH
Ma
The Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Xiang-Yu
XY
Qiu
The Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China;; Translational Lung Research Centre Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Arne
A
Warth
Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.
Nobuhiko
N
Seki
Department of Diagnostic Radiology, Saitama International Medical Center, Saitama Medical University, Saitama, Japan;; Department of Respiratory Medicine, Tokyo Women's Medical University, Yachiyo Medical Center, Tokyo, Japan.
Mizue
M
Hasegawa
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Jia-Wei
JW
Zou
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Qian
Q
Li
Università degli studi di Milano, Postgraduation School in Radiodiagnostics, Milan, Italy.
Marco
M
Femia
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Tang-Feng
TF
Lv
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Yong
Y
Song
Ground-glass opacity (GGO); Kirsten rat sarcoma viral oncogene homolog (KRAS); anaplastic lymphoma kinase gene (ALK); computed tomography (CT); driver genes; epidermal growth factor receptor gene (EGFR); pathology