Synthesis and antimicrobial properties of 4-acylaminobenzenethiosulfoacid S-esters.
A series of esters of 4-acetyl, 4-trifluoroacetyl- and 4-(3-chloropropionyl)aminobenzenethiosulfoacids (twenty-four compounds) were synthesized and characterized by elemental analysis,1H NMR and IR spectroscopy. The antibacterial activity of the novel candidates has been screened using the agar diffusion or serial dilution methods against representative Gram-positive (Staphylococcus aureus,Bacillus subtilis,Bacillus mesentericus,Mycobacteriumsp.,Mycobacterium luteum), Gram-negative (Aeromonassp.,Burkholderia cepacia,Alcaligenes faecalis,Pseudomonas aeruginosa,Escherichia coli,Proteus vulgaris) bacteria and fungi (Candida albicans,Candida tenuis,Candida glabrata,Verticillium dahliae,Trichophyton gypseum,Aspergillus niger,Aspergillus fumigatus,Penicillium chrysogenum). Particular potency has been discovered against all tested pathogenic bacteria and fungi by compounds1land3lat nanomolar concentrations. Some appropriate effect of thiosulfoesters structure upon their antimicrobial activity was determined.
Department of Technology of Biologically Active Substances, Pharmacy & Biotechnology, Lviv National Polytechnic University, S. Bandery Str. 12, Lviv, Ukraine.
Vira
V
Lubenets
Department of Technology of Biologically Active Substances, Pharmacy & Biotechnology, Lviv National Polytechnic University, S. Bandery Str. 12, Lviv, Ukraine.
Sofiya
S
Vasylyuk
Department of Technology of Biologically Active Substances, Pharmacy & Biotechnology, Lviv National Polytechnic University, S. Bandery Str. 12, Lviv, Ukraine.
Nataliya
N
Monka
Department of Technology of Biologically Active Substances, Pharmacy & Biotechnology, Lviv National Polytechnic University, S. Bandery Str. 12, Lviv, Ukraine.
Khrystyna
K
Bolibrukh
Department of Technology of Biologically Active Substances, Pharmacy & Biotechnology, Lviv National Polytechnic University, S. Bandery Str. 12, Lviv, Ukraine.
Olena
O
Komarovska-Porokhnyavets
Department of Technology of Biologically Active Substances, Pharmacy & Biotechnology, Lviv National Polytechnic University, S. Bandery Str. 12, Lviv, Ukraine.
Diana
D
Baranovych
Department of Technology of Biologically Active Substances, Pharmacy & Biotechnology, Lviv National Polytechnic University, S. Bandery Str. 12, Lviv, Ukraine.
Rostyslav
R
Musyanovych
Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, R. Weigla Str. 12, 53-114 Wrocław, Poland.
Ewa
E
Zaczynska
Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, R. Weigla Str. 12, 53-114 Wrocław, Poland.
Anna
A
Czarny
Department of Pharmaceutical Microbiology and Parasitology, Wrocław Medical University, T. Chałubińskiego Street 4, 50-368 Wrocław, Poland.
Urszula
U
Nawrot
Department of Technology of Biologically Active Substances, Pharmacy & Biotechnology, Lviv National Polytechnic University, S. Bandery Str. 12, Lviv, Ukraine.
Volodymyr
V
Novikov
Antimicrobial activity; Bactericidal activity; Fungicidal activity; Thiosulfoacid derivatives; Thiosulfoesters