Artificial and natural RNA interactions between bacteria and C. elegans.
Nineteen years after Lisa Timmons and Andy Fire first described RNA transfer from bacteria to C. elegans in an experimental setting48the biologic role of this trans-kingdom RNA-based communication remains unknown. Here we summarize our current understanding on the mechanism and potential role of such social RNA.
a Gurdon Institute, University of Cambridge , Cambridge , UK.|b Department of Genetics , University of Cambridge , Cambridge , UK.
Fabian
F
Braukmann
a Gurdon Institute, University of Cambridge , Cambridge , UK.|b Department of Genetics , University of Cambridge , Cambridge , UK.
David
D
Jordan
a Gurdon Institute, University of Cambridge , Cambridge , UK.|b Department of Genetics , University of Cambridge , Cambridge , UK.|c Wellcome Trust Sanger Institute , Wellcome Trust Genome Campus, Cambridge , UK.
Eric
E
Miska
D000821:Animal Feed; D000818:Animals; D001419:Bacteria / Q000235:genetics*; D017173:Caenorhabditis elegans / Q000235:genetics*; D005786:Gene Expression Regulation; D034622:RNA Interference; D012329:RNA, Bacterial / Q000235:genetics; D018510:RNA, Helminth / Q000235:genetics
D012329:RNA, Bacterial; D018510:RNA, Helminth
Bacteria; C. elegans; environmental RNAi; mobile RNA