Changes in the Level of Immunoglobulins and CD4/CD8 Ratio in Young and Aged Mice with Estradiol Deficiency.
Studies demonstrated that deficiency in 17β-estradiol (E2) in postmenopausal women influences their immune system. However, few studies have reported alterations in immunologic presentation during nonnatural menopause in young females. Here we compared the differences in immune response between young C57BL/6N mice with surgical or medical variectomy and aged C57BL/6N mice with the common feature of E2deficiency following Con A stimulation. We observed inverted CD4/CD8 ratios in the aged group and apparent reduced production of serum immunoglobin (Ig)G, IgA, and IgM in the surgical group, whereas changes in immune parameters in the medical group were moderate. These data suggested that the immunological response to Con A stimulus differed among the three groups and that E2deficiency was only partially responsible for the development of immune deficiency in aged mice.
a Department of Obstetrics and Gynecology , Jinhua Municipal Central Hospital , Zhejiang Province , People's Republic of China.
Ming-Jun
MJ
Shao
a Department of Obstetrics and Gynecology , Jinhua Municipal Central Hospital , Zhejiang Province , People's Republic of China.
Yi-Jun
YJ
Zhu
b Jinhua Drug Checking Institute , Zhejiang Province , People's Republic of China.
Ying-Er
YE
Qiu
a Department of Obstetrics and Gynecology , Jinhua Municipal Central Hospital , Zhejiang Province , People's Republic of China.
Min
M
Hu
a Department of Obstetrics and Gynecology , Jinhua Municipal Central Hospital , Zhejiang Province , People's Republic of China.
Yun-Qin
YQ
He
D000375:Aging / Q000502:physiology*; D000818:Animals; D016516:CD4-CD8 Ratio; D003208:Concanavalin A / Q000276:immunology; D004195:Disease Models, Animal; D004958:Estradiol / Q000172:deficiency*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008213:Lymphocyte Activation; D008594:Menopause, Premature / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010052:Ovariectomy; D017698:Postmenopause / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003208:Concanavalin A; D004958:Estradiol
Aging; CD4/CD8 ratio; estrogen; immunoglobulin; variectomy