Relationships between acrylamide and glycidamide hemoglobin adduct levels and allergy-related outcomes in general US population, NHANES 2005-2006.
BACKGROUND
Acrylamide-induced immunotoxicity and allergic dermatitis have been reported in animal experiments and clinical reports, respectively. However, epidemiological evidence from the general population is limited.


OBJECTIVE
The purpose of the present study was to estimate the associations between acrylamide exposure and allergy-related outcomes in the general US population.


METHODS
A total of 6982 subjects were selected from the National Health and Nutrition Examination Survey 2005-2006 (NHANES). Internal exposure was measured by the hemoglobin adducts of acrylamide (HbAA) and its metabolite glycidamide (HbGA). Allergy-related outcomes including asthma, hay fever, allergy, itchy rash, sneeze, wheeze and eczema were obtained by self-administered questionnaires. Allergic sensitization was assessed by the total immunoglobulin E (IgE) levels. The associations of HbAA and HbGA quartiles with allergy-related outcomes were calculated using logistic regression models with multivariable adjustments. Analyses were additionally stratified according to age, gender and serum cotinine levels.


RESULTS
When setting quartile 1 of HbAA as reference, the odds ratios (ORs) [95% confidence intervals (CIs)] of quartile 2 to 4 for eczema were 1.18 (0.79-1.76), 1.14 (0.73-1.78) and 1.58 (1.14-2.18), respectively (ptrend= 0.002). Individuals at the highest quartile of HbGA had significantly elevated likelihoods of itchy rash (OR = 1.37, 95% CI = 1.02-1.83, ptrend= 0.032) and eczema (OR = 1.45, 95% CI = 1.06-1.97, ptrend= 0.044). The stratification analyses indicated various results in different subgroups.


CONCLUSIONS
This study indicated significant associations between HbAA and HbGA levels and the likelihoods of allergy-related outcomes in the general US population, depending on age, gender and smoke exposure status. These findings suggested potential public health concerns for the widespread exposure to acrylamide.
Institute of Environmental Health, Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Jing
J
Guo
Institute of Environmental Health, Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Dongdong
D
Yu
Institute of Environmental Health, Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Na
N
Lv
Institute of Environmental Health, Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Rongpan
R
Bai
Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Chunjing
C
Xu
Institute of Environmental Health, Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: chenguangdi@zju.edu.cn.
Guangdi
G
Chen
School of Humanities and Social Sciences, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address: cwm@zju.edu.cn.
Weiming
W
Cao
D020106:Acrylamide / Q000378:metabolism* / Q000633:toxicity; D000328:Adult; D000818:Animals; D001249:Asthma; D004781:Environmental Exposure / Q000032:analysis / Q000706:statistics & numerical data*; D004852:Epoxy Compounds / Q000378:metabolism* / Q000633:toxicity; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D016017:Odds Ratio; D006255:Rhinitis, Allergic, Seasonal; D014481:United States
D004852:Epoxy Compounds; D006454:Hemoglobins; D020106:Acrylamide; C071834:glycidamide
Acrylamide; Allergy; Glycidamide; Hemoglobin adducts; NHANES