Emerging CAM Ziziphus nummularia with in vivo sedative-hypnotic, antipyretic and analgesic attributes.
Ziziphus nummularia from Rhamnaceae family is traditionally used for sedative-hypnotic, antipyretic and analgesic purposes; however, scientific validations are lacking. This in vivo study was undertaken to verify the above ameliorative properties of Z. nummularia root methanolic extract. Various fractions of the extract were assayed on Balb/c mice by open field, Brewer's yeast-induced hyperthermia and acetic acid-induced writhing experiments. The significance of the outcomes was analyzed with statistical tests. Various fractions of the extract exhibited marked dose-dependent (p < 0.05) sedative-hypnotic and antipyretic activities. The biological efficacies were most pronounced between 50 and 100 mg/kg. Further, the acetic acid-induced abdominal constrictions were significantly (p < 0.05) attenuated by the extract. Chloroform fraction of the extract was most dominant followed by ethyl acetate. The demonstrated therapeutic attributes of Z. nummularia extract can be exploited to isolate pharmaceutically relevant compounds.
Department of Geology, University of Swabi, Anbar, Khyber Pakhtunkhwa, 23561, Pakistan. mashaljcs@yahoo.com.
Abdur
A
Rauf
Institute of Chemical Sciences, University of Peshawar, Peshawar, KP, 25120, Pakistan.
Jawad
J
Ali
Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan.
Haroon
H
Khan
Department of Chemistry, The University of Jordan, Amman, 11942, Jordan.
Mohammad S
MS
Mubarak
Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego, CA, 92182, USA. seemabiotech83@gmail.com.
Seema
S
Patel
Anti-inflammation; Antinociceptive; Antipyretic; Hypnotic; Sedative; Ziziphus nummularia