Intranodal meningothelial proliferation in a patient with Cowden syndrome: a case report.
Ectopic meningothelial proliferations are rare and can occur in a multitude of extracranial/spinal anatomic locations. Perineurioma is another uncommon entity that shares similar histological characteristics to those found in meningothelial proliferations. These include bland spindle cells with thin, bipolar nuclei; eosinophilic cytoplasm; and indistinct cell borders, arranged in short fascicles with whorl formation. Given their uncommon occurrence and shared histological and immunohistochemical features, their distinction can present a diagnostic challenge. Immunohistochemical studies can provide guidance when attempting to distinguish between these 2 lesions. Here, we present an unusual case of a patient with Cowden syndrome who was discovered to have a meningothelial proliferation within an axillary lymph node. To the best of our knowledge, this is the first case in which a meningothelial proliferation has been identified in a lymph node. Furthermore, the occurrence in a patient with Cowden syndrome is intriguing and raises the possibility of a pathogenetic link.
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756, USA.
Andrea
A
Olofson
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756, USA.
Jonathan
J
Marotti
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756, USA.
Laura J
LJ
Tafe
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756, USA. Electronic address: Konstantinos.linos@hitchcock.org.
Konstantinos
K
Linos
D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D049109:Cell Proliferation; D002828:Choristoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006223:Hamartoma Syndrome, Multiple / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D018317:Nerve Sheath Neoplasms / Q000737:chemistry / Q000473:pathology*; D011237:Predictive Value of Tests
D014408:Biomarkers, Tumor
Cowden; Ectopic meningioma; Lymph node; Meningothelial; Perineurioma