Risk factors for pressure injury development in critically ill patients in the intensive care unit: a systematic review protocol.
Pressure injuries (PIs) create a significant burden in the health care system. Up to 49% of critically ill patients develop PIs. Identifying and understanding potential risk factors is essential to the provision of effective targeted prevention strategies to mitigate risk. The objectives of this review are to identify patient-centred clinical factors that may be associated with PI development in the adult intensive care environment and to determine the effect size of the relationship between identified factors and PI development in this unique population.



The review will follow the PRISMA reporting guidelines for systematic reviews. Electronic databases (Cochrane; PubMed/MEDLINE; CINAHL (EBSCOhost); Embase; Scopus; PsycINFO; Proquest; Networked Digital Library of Theses and Dissertations; Australian Digital Theses Program, Grey literature, Google scholar, and Clinical Trial Registries) will be systematically searched. A suite of search terms will identify articles that have examined the patient-centred risk factors for PI development in adult intensive care units. The search strategy will be designed to retrieve studies published since inception to 2016 in English language. Quality of the studies will be assessed by using an assessment framework designed to appraise quality in prognostic studies and methodological considerations in the analysis and publication of observational studies. Screening, study selection process, and data extraction will be undertaken by two independent reviewers. Disagreement will be resolved by discussion and, if required, a third independent reviewer. Clinical and methodological heterogeneity across studies will be assessed and, if possible, meta-analyses will be performed.



The evidence synthesis arising from this review will identify person-centred risk factors that are associated with PI development among critically ill patients in intensive care. Findings from this review will demonstrate potential patient risk factors that may influence practice and research priorities to prevent PI development and improve the quality of care provided.



PROSPERO CRD42016037690.
School of Nursing, Queensland University of Technology, Victoria Park Rd, Kelvin Grove, Queensland, 4059, Australia. f.coyer@qut.edu.au.|Intensive Care Services, Royal Brisbane and Women's Hospital, Butterfield St, Herston, Queensland, 4006, Australia. f.coyer@qut.edu.au.|Institute for Skin Integrity and Infection Prevention, University of Huddersfield, Huddersfield, UK. f.coyer@qut.edu.au.
Fiona
0000-0002-8467-0081
F
Coyer
School of Nursing, Queensland University of Technology, Victoria Park Rd, Kelvin Grove, Queensland, 4059, Australia.|School of Nursing, Umm Al-Qura University, Mecca, Saudi Arabia.
Nahla
N
Tayyib
D016638:Critical Illness / Q000628:therapy*; D006801:Humans; D007362:Intensive Care Units; D003668:Pressure Ulcer / Q000517:prevention & control*; D012307:Risk Factors; D000078202:Systematic Reviews as Topic
Intensive/critical care; Predictors; Pressure injury; Pressure ulcer; Risk factors