Protecting impact of Jaft against carbendazim induced biochemical changes in male Wistar rats.
Introduction:Pesticides are a critical tool for crop protection and control of different pests and insects. The present research conducted to evaluate the protective role of Jaft extract against oxidative pressure, biochemical variations because of limited time giveaway to carbendazim in Wistar mice males. Fresh fruits ofquercus brantiiwere dried and the internal layer (Jaft) was collected for a hydroalcoholic extract by a maceration method at normal ambient condition. For the experimental study, twenty-four adult male rats (Wistar albino rats weighing 150-200 g) were randomized into 3 teams out of eight. Team I subserved like a vehicle treated group, received corn oil additionally to their food, while the animals in the second team got 0.1 ml carbendazim (50mg/ kg in corn oil) via oral path for nine days. Rats in group III received Jaft (500 mg/ kg orally + in carbendazim for 9 days. Blood samples were obtained by heart puncture to determine alkaline phosphatase (ALP), blood urea nitrogen (BUN), creatinine, alanine (ALT) and aspartate aminotransferases (AST); by using auto-analyzer in serum.Kidneys and liver separated from rats and provided for series of biochemical parameters homogenization like GSH and MDA stages.Result:The serum content of AST, ALT, ALP, BUN and creatinine were significantly elevated by in carbendazim treatment (group II) compared to the negative group (p<0.01).The liver enzymes operations, creatinine and BUN were significantly reduced in rats (p<0.05) when Jaft was received in a short period of time (group III). Hepatic and GSH and renal MDA stages in group (II) were clearly (p<0.05) enhanced and decreased consequently. The GSH and MDA stages content were significantly normalized in mice (p<0.05) when Jaft was received by group III.Conclusions:According to the present data, Jaft can neutralize carbendazim contain pressure of oxidative and recover the abnormal pathological injuries in Wistar mice males.
Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
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Mirzaei
Department of Biotechnology, Fergusson College, Pune - 414001, Maharashtra, India.
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Sepehri
Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
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Sadeghi
Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
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Alamdari