Randomised controlled trial demonstrates that fermented infant formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides reduces the incidence of infantile colic.
OBJECTIVE
We examined the effects on gastrointestinal (GI) tolerance of a novel infant formula that combined specific fermented formula (FERM) with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS), with a 9:1 ratio and concentration of 0.8 g/100 mL.


METHODS
This prospective, double-blind, randomised, controlled trial comprised 432 healthy, term infants aged 0-28 days whose parents decided to not start, or discontinued, breastfeeding. Infant formula with scGOS/lcFOS+50%FERM, scGOS/lcFOS+15%FERM, 50%FERM and scGOS/lcFOS were tested. Parents completed standardised seven-day diaries on GI symptoms, crying, sleeping and stool characteristics each month until the infants were 17 weeks.


RESULTS
All the formulas were well tolerated. At four weeks, the overall incidence of infantile colic was significantly lower (8%) with scGOS/lcFOS+50%FERM than scGOS/lcFOS (20%, p = 0.034) or 50%FERM (20%, p = 0.036). Longitudinal modelling showed that scGOS/lcFOS+50%FERM-fed infants also displayed a persistently lower daily crying duration and showed a consistent stool-softening effect than infants who received formula without scGOS/lcFOS.


CONCLUSIONS
The combination of fermented formula with scGOS/lcFOS was well tolerated and showed a lower overall crying time, a lower incidence of infantile colic and a stool-softening effect in healthy term infants. These findings suggest for the first time that a specific infant formula has a preventive effect on infantile colic in formula-fed infants.
Department of Pediatrics, UZ, Vrije Universiteit Brussel, Brussels, Belgium.
Yvan
Y
Vandenplas
Nutricia Research, Utrecht, The Netherlands.
Thomas
T
Ludwig
Nutricia Research, Utrecht, The Netherlands.
Hetty
H
Bouritius
Kinderartsenpraktijk, Hasselt, Belgium.
Philippe
P
Alliet
Slaney Medical Centre, Enniscorthy, Ireland.
Derek
D
Forde
Algemeen Stedelijk Ziekenhuis Aalst, Aalst, Belgium.
Stefaan
S
Peeters
Pédiatrie, Hôpital d'Enfants, Dijon, France.
Frederic
F
Huet
Paediatrics and Child Health, University College Cork, Cork, Ireland.
Jonathan
J
Hourihane
D003085:Colic / Q000517:prevention & control*; D003448:Crying; D043302:Cultured Milk Products; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007231:Infant, Newborn; D009844:Oligosaccharides / Q000627:therapeutic use*; D056692:Prebiotics; D011446:Prospective Studies
D009844:Oligosaccharides; D056692:Prebiotics
Fermented formula; Gastrointestinal tolerance; Infant formula; Infantile colic; Prebiotic