Intact parathyroid hormone levels and primary hyperparathyroidism.
OBJECTIVE
The aim of this article is to compare clinical characteristics and lab values for metabolic syndrome between primary hyperparathyroidism (PHPT) patients with different levels of serum intact parathyroid hormone (iPTH) and to determine correlation between different clinical characteristics among PHPT patients Methods: We reviewed charts of 212 PHPT patients in this retrospective study. Patients were divided into two groups according to their initial serum iPTH levels. Student's t-tests were used to compare the two groups for differences in clinical characteristics and laboratory values. Pearson's correlation coefficients were used to assess associations.


RESULTS
Of the 212 PHPT patients, 100 were classified as m-iPTH group (serum iPTH < 140 pg/mL), whereas 112 patients were defined as h-iPTH group (serum iPTH ≥ 140 pg/mL). The h-iPTH patients were younger, had higher serum calcium and alkaline phosphatase levels, but exhibited lower 25(OH)-vitamin D and HDL levels, when compared with those of m-iPTH patients. Adenoma weights in the h-iPTH group tended to be higher than that in the m-iPTH group. Furthermore, association studies revealed that the iPTH level was positively correlated with adenoma weight and serum calcium and triglyceride (TG) levels but negatively correlated with HDL level.


CONCLUSIONS
Our study supports the hypothesis that iPTH level is associated with TG and HDL levels and should be a factor to consider in the management of PHPT patients.
a Division of Endocrinology, Metabolism & Nutrition , Department of Medicine, Rutgers University-Robert Wood Johnson Medical School , New Brunswick , NJ , USA.
Haidar
H
Al-Hraishawi
a Division of Endocrinology, Metabolism & Nutrition , Department of Medicine, Rutgers University-Robert Wood Johnson Medical School , New Brunswick , NJ , USA.
Peter J
PJ
Dellatore
a Division of Endocrinology, Metabolism & Nutrition , Department of Medicine, Rutgers University-Robert Wood Johnson Medical School , New Brunswick , NJ , USA.|b Department of Medicine , Icahn School of Medicine at Mount Sinai (James J. Peters VA Bronx) , New York , NY , USA.
Xinjiang
X
Cai
a Division of Endocrinology, Metabolism & Nutrition , Department of Medicine, Rutgers University-Robert Wood Johnson Medical School , New Brunswick , NJ , USA.
Xiangbing
X
Wang
D000236:Adenoma / Q000097:blood* / Q000150:complications; D000328:Adult; D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood* / Q000209:etiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010282:Parathyroid Neoplasms / Q000097:blood* / Q000150:complications; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood*
D008076:Cholesterol, HDL; D010281:Parathyroid Hormone; D014280:Triglycerides
Calcium; hyperparathyroidism; lipid; metabolic syndrome; parathyroid hormone