Multifunctional Inorganic Nanoparticles: Recent Progress in Thermal Therapy and Imaging.
Nanotechnology has enabled the development of many alternative anti-cancer approaches, such as thermal therapies, which cause minimal damage to healthy cells. Current challenges in cancer treatment are the identification of the diseased area and its efficient treatment without generating many side effects. Image-guided therapies can be a useful tool to diagnose and treat the diseased tissue and they offer therapy and imaging using a single nanostructure. The present review mainly focuses on recent advances in the field of thermal therapy and imaging integrated with multifunctional inorganic nanoparticles. The main heating sources for heat-induced therapies are the surface plasmon resonance (SPR) in the near infrared region and alternating magnetic fields (AMFs). The different families of inorganic nanoparticles employed for SPR- and AMF-based thermal therapies and imaging are described. Furthermore, inorganic nanomaterials developed for multimodal therapies with different and multi-imaging modalities are presented in detail. Finally, relevant clinical perspectives and the future scope of inorganic nanoparticles in image-guided therapies are discussed.
Department of Biomedical Science and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, Korea. cherrikonda@gmail.com.
Kondareddy
K
Cherukula
Department of Biomedical Science and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, Korea. kamali.mvasagam@gmail.com.
Kamali
K
Manickavasagam Lekshmi
Department of Biomedical Science and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, Korea. sajiuthaman@gmail.com.
Saji
S
Uthaman
Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea. andrew.kihyun.cho@gmail.com.
Kihyun
K
Cho
Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea. chocs@snu.ac.kr.
Chong-Su
CS
Cho
Department of Biomedical Science and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, Korea. pik96@chonnam.ac.kr.
In-Kyu
IK
Park
alternate magnetic field; image-guided therapy; imaging; inorganic nanoparticles; photothermal therapy; surface plasmon resonance