Difference in imaging biomarkers of neurodegeneration between early and late-onset amnestic Alzheimer's disease.
Neuroimaging biomarkers differ between patients with early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD). Whether these changes reflect cognitive heterogeneity or differences in disease severity is still unknown. This study aimed at investigating changes in neuroimaging biomarkers, according to the age of onset of the disease, in mild amnestic Alzheimer's disease patients with positive amyloid biomarkers in cerebrospinal fluid. Both patient groups were impaired on tasks assessing verbal and visual recognition memory. EOAD patients showed greater executive and linguistic deficits, while LOAD patients showed greater semantic memory impairment. In EOAD and LOAD, hypometabolism involved the bilateral temporoparietal junction and the posterior cingulate cortex. In EOAD, atrophy was widespread, including frontotemporoparietal areas, whereas it was limited to temporal regions in LOAD. Atrophic volumes were greater in EOAD than in LOAD. Hypometabolic volumes were similar in the 2 groups. Greater extent of atrophy in EOAD, despite similar extent of hypometabolism, could reflect different underlying pathophysiological processes, different glucose-based compensatory mechanisms or distinct level of premorbid atrophic lesions.
Aix-Marseille Université, INSERM UMR 1106, Institut de Neurosciences des Systèmes, Marseille, France. Electronic address: anne-laure.aziz@hotmail.fr.
Anne-Laure
AL
Aziz
Aix-Marseille Université, INSERM UMR 1106, Institut de Neurosciences des Systèmes, Marseille, France; APHM, Public Health Department, Marseille, France.
Bernard
B
Giusiano
Département de psychologie, Université de Montréal, Montréal, Quebec, Canada; Centre de recherche Institut universitaire de gériatrie de Montréal (CRIUGM), Montréal, Quebec, Canada.
Sven
S
Joubert
Aix-Marseille Université, Centre de Résonance Magnétique Biologique et Médicale - CRMBM, UMR 7339 AMU-CNRS, Marseille, France.
Lauréline
L
Duprat
Aix-Marseille Université, INSERM UMR 1106, Institut de Neurosciences des Systèmes, Marseille, France; Neurology and Neuropyschology Department & CMRR PACA Ouest, AP-HM, Marseille, France.
Mira
M
Didic
Neurology and Neuropyschology Department & CMRR PACA Ouest, AP-HM, Marseille, France.
Claude
C
Gueriot
Neurology and Neuropyschology Department & CMRR PACA Ouest, AP-HM, Marseille, France.
Lejla
L
Koric
Immunology and Immunopathology Department, Assistance Publique-Hôpitaux de Marseille, Marseille, France; Aix Marseille Université, CRN2M, CNRS UMR 7286, Marseille Cedex 15, France.
José
J
Boucraut
Aix-Marseille Université, INSERM UMR 1106, Institut de Neurosciences des Systèmes, Marseille, France; Neurology and Neuropyschology Department & CMRR PACA Ouest, AP-HM, Marseille, France.
Olivier
O
Felician
Aix-Marseille Université, Centre de Résonance Magnétique Biologique et Médicale - CRMBM, UMR 7339 AMU-CNRS, Marseille, France.
Jean-Philippe
JP
Ranjeva
Nuclear Medicine Department, Assistance Publique-Hôpitaux de Marseille, Timone Hospital, Marseille, France; Institut de Neurosciences de la Timone, UMR 7289, Aix-Marseille Université & CNRS, Assistance Publique-Hôpitaux de Marseille, Marseille, France; CERIMED, Aix-Marseille Université, Marseille, France.
Eric
E
Guedj
Aix-Marseille Université, INSERM UMR 1106, Institut de Neurosciences des Systèmes, Marseille, France; Neurology and Neuropyschology Department & CMRR PACA Ouest, AP-HM, Marseille, France.
Mathieu
M
Ceccaldi
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D000682:Amyloid / Q000134:cerebrospinal fluid; D001284:Atrophy; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D003071:Cognition; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D008875:Middle Aged; D009410:Nerve Degeneration; D059906:Neuroimaging; D049268:Positron-Emission Tomography; D012720:Severity of Illness Index
D000682:Amyloid; D015415:Biomarkers; D005947:Glucose
Age of onset; Alzheimer's disease; Magnetic resonance imaging; Neuroimaging biomarkers; Positron emission tomography imaging