Infantile fibrosarcoma treated with postoperative vincristine and dactinomycin.
Infantile fibrosarcoma is a non-rhabdomyosarcoma soft-tissue sarcoma that occurs in infancy and which has a relatively good prognosis. A vincristine and dactinomycin (VA) regimen has been shown to be effective, although the duration of chemotherapy has not been well defined. We describe the case of a 4-month-old boy with a mass at the left dorsum of the foot who was diagnosed with infantile fibrosarcoma after resection of the tumor, the margin of which was macroscopically positive. VA treatment was carried out with careful monitoring of response and adverse effects. Pancytopenia was seen during the second cycle, and therapy was reduced thereafter. The treatment was continued for 38 weeks (12 cycles). There was no functional impairment, and no evidence of recurrence at 18 months after therapy.
Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
Hiroki
H
Yoshihara
Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
Yuri
Y
Yoshimoto
Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
Yosuke
Y
Hosoya
Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
Daisuke
D
Hasegawa
Department of Pediatric Surgery, St Luke's International Hospital, Tokyo, Japan.
Takafumi
T
Kawano
Department of Pediatric Surgery, St Luke's International Hospital, Tokyo, Japan.
Akiko
A
Sakoda
Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, National Center for Child Health and Development, Tokyo, Japan.|Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
Hajime
H
Okita
Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
Atsushi
A
Manabe
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003609:Dactinomycin / Q000627:therapeutic use*; D005354:Fibrosarcoma / Q000188:drug therapy* / Q000601:surgery; D005528:Foot / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000601:surgery; D014750:Vincristine / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D003609:Dactinomycin; D014750:Vincristine
adjuvant chemotherapy; dactinomycin; fibrosarcoma; infant; vincristine