Association of native T1 times with biventricular function and hemodynamics in precapillary pulmonary hypertension.
In precapillary pulmonary hypertension (PH) patients, we sought to (1) investigate the relationship between ventricular insertion point (VIP) T1 times, hemodynamic parameters, and biventricular function, and (2) determine the predictors of anterior and inferior VIP T1 time. Twenty-two patients with precapillary PH underwent 1.5-T cardiac MR, right heart catheterization (RHC), and echocardiography. A group of 10 healthy age- and sex-matched volunteers served as controls. Biventricular function, morphology and mass were obtained from short-axis cine images. Native T1 times at anterior, inferior VIP, septum and LV lateral wall were respectively derived from all subjects. Mixed venous oxygen saturation (SvO2) was the strongest hemodynamic parameters correlating with anterior (rp= -0.67, P = 0.001) and inferior VIP T1 time (rp= -0.81, P < 0.001). Elevated VIP T1 times were associated with reduced right ventricular (RV) ejection fraction, RV longitudinal and transverse motion, and increased RV end-diastolic and end-systolic volume index. LV diastolic function, quantified as mitral E velocity, was negatively correlated with anterior, inferior VIP (rp= -0.55, P = 0.01) and septal T1 times (rp= -0.50, P = 0.02), and positively correlated with RV systolic function and wall motion. In multivariate linear regression analyses, systolic eccentricity index (sEI) was the independent predictor of average VIPs T1 time (β= 0.47, P < 0.01), and remained significant correlation after adjustment of RHC and demographic parameters. In patients with precapillary PH, VIP T1 times are associated with biventricular function and hemodynamic parameters. Among all the parameters, sEI acts as a determinant of average VIPs T1 time.
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.|Department of Medical Imaging, Shanghai Medical school, Fudan University, Shanghai, China.|Shanghai Institute of Medical Imaging, Fenglin Road 180, Shanghai, China.
Yin Yin
YY
Chen
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.|Department of Medical Imaging, Shanghai Medical school, Fudan University, Shanghai, China.|Shanghai Institute of Medical Imaging, Fenglin Road 180, Shanghai, China.
Hong
H
Yun
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.|Department of Medical Imaging, Shanghai Medical school, Fudan University, Shanghai, China.|Shanghai Institute of Medical Imaging, Fenglin Road 180, Shanghai, China.
Hang
H
Jin
Department of Echocardiography, Zhongshan Hospital, Fudan University, 180#, Fenglin Road, Shanghai, China.
De Hong
H
Kong
Department of Cardiology, Zhongshan Hospital, Fudan University, 180#, Fenglin Road, Shanghai, China.
Yu Liang
YL
Long
Siemens Shenzhen Magnetic Resonance (C.F.), Shenzhen, China.
Cai Xia
CX
Fu
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China. yangshan67@sina.com.|Department of Medical Imaging, Shanghai Medical school, Fudan University, Shanghai, China. yangshan67@sina.com.|Shanghai Institute of Medical Imaging, Fenglin Road 180, Shanghai, China. yangshan67@sina.com.
Shan
S
Yang
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China. zengmengsu@outlook.com.|Department of Medical Imaging, Shanghai Medical school, Fudan University, Shanghai, China. zengmengsu@outlook.com.|Shanghai Institute of Medical Imaging, Fenglin Road 180, Shanghai, China. zengmengsu@outlook.com.
Meng Su
MS
Zeng
D000293:Adolescent; D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D016022:Case-Control Studies; D015150:Echocardiography, Doppler; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016014:Linear Models; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009200:Myocardial Contraction; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D013318:Stroke Volume; D013997:Time Factors; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right; D055815:Young Adult
Biventricular function; Native T1 time; Pulmonary hypertension; T1-mapping