Suppression of the Smurf1 Expression Inhibits Tumor Progression in Gliomas.
Glioblastoma, one of the common malignant brain tumors, results in the highly death, but its underlying molecular mechanisms remain unclear. Smurf1, a member of Nedd4 family of HECT-type ligases, has been reported to contribute to tumorigenicity through several important biological pathways. Recently, it was also found to participate in modulate cellular processes, including morphogenesis, autophagy, growth, and cell migration. In this research, we reported the clinical guiding significance of the expression of Smurf1 in human glioma tissues and cell lines. Western blotting analysis discovered that the expression of Smurf1 was increased with WHO grade. Immunohistochemistry levels discovered that high expression of Smurf1 is closely consistent with poor prognosis of glioma. In addition, suppression of Smurf1 can reduce cell invasion and increase the E-cadherin expression, which is a marker of invasion. Our study firstly demonstrated that Smurf1 may promote glioma cell invasion and suppression of the Smurf1 may provide a novel treatment strategy for glioma.
Department of Neurosurgery, Wuxi Second Hospital Affiliated to Nanjing Medical University, 68 Zhongshan Road, Wuxi, 214002, Jiangsu, China.
Hao
H
Chang
Department of Neurosurgery, Wuxi Second Hospital Affiliated to Nanjing Medical University, 68 Zhongshan Road, Wuxi, 214002, Jiangsu, China.
Jingning
J
Zhang
Department of Neurosurgery, Wuxi Second Hospital Affiliated to Nanjing Medical University, 68 Zhongshan Road, Wuxi, 214002, Jiangsu, China.
Zengli
Z
Miao
Department of Neurosurgery, Taizhou People's Hospital Affiliated to Nantong University, 399 Hailing Road, Taizhou, 225300, Jiangsu, China.
Yasuo
Y
Ding
Department of Neurosurgery, Wuxi Second Hospital Affiliated to Nanjing Medical University, 68 Zhongshan Road, Wuxi, 214002, Jiangsu, China.
Xing
X
Xu
Department of Neurosurgery, Wuxi Second Hospital Affiliated to Nanjing Medical University, 68 Zhongshan Road, Wuxi, 214002, Jiangsu, China.
Xudong
X
Zhao
Department of Pathology, Nantong University, 19 Qixiu Road, Nantong, 226001, Jiangsu, China.
Peng
P
Xu
Department of Neurosurgery, Wuxi Second Hospital Affiliated to Nanjing Medical University, 68 Zhongshan Road, Wuxi, 214002, Jiangsu, China.
Qing
Q
Wang
Department of Neurosurgery, Wuxi Second Hospital Affiliated to Nanjing Medical University, 68 Zhongshan Road, Wuxi, 214002, Jiangsu, China. yuchang_lin@sina.com.
Yuchang
Y
Lin
D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D044767:Ubiquitin-Protein Ligases / Q000096:biosynthesis / Q000235:genetics*
C498342:SMURF1 protein, human; D044767:Ubiquitin-Protein Ligases
Apoptosis; Glioma; Migration; Smurf1