ResistoMap-online visualization of human gut microbiota antibiotic resistome.
We created ResistoMap—a Web-based interactive visualization of the presence of genetic determinants conferring resistance to antibiotics, biocides and heavy metals in human gut microbiota. ResistoMap displays the data on more than 1500 published gut metagenomes of world populations including both healthy subjects and patients. Multiparameter display filters allow visual assessment of the associations between the meta-data and proportions of resistome. The geographic map navigation layer allows to state hypotheses regarding the global trends of antibiotic resistance and correlates the gut resistome variations with the national clinical guidelines on antibiotics application.



ResistoMap was implemented using AngularJS, CoffeeScript, D3.js and TopoJSON. The tool is publicly available at http://resistomap.rcpcm.org.



yarygin@phystech.edu.



Supplementary data are available at Bioinformatics online.
Moscow Institute of Physics and Technology (MIPT), 9 Institutskiy per, Dolgoprudny, Moscow Region, Russian Federation.|Federal Research and Clinical Centre of Physical-Chemical Medicine (FRCC PCM), Malaya Pirogovskaya 1a, Moscow, Russian Federation.
Konstantin S
KS
Yarygin
Federal Research and Clinical Centre of Physical-Chemical Medicine (FRCC PCM), Malaya Pirogovskaya 1a, Moscow, Russian Federation.
Boris A
BA
Kovarsky
Data Laboratory, Kostycheva 64-12, Bryansk, Russian Federation.
Tatyana S
TS
Bibikova
Data Laboratory, Kostycheva 64-12, Bryansk, Russian Federation.
Damir S
DS
Melnikov
Moscow Institute of Physics and Technology (MIPT), 9 Institutskiy per, Dolgoprudny, Moscow Region, Russian Federation.|Federal Research and Clinical Centre of Physical-Chemical Medicine (FRCC PCM), Malaya Pirogovskaya 1a, Moscow, Russian Federation.
Alexander V
AV
Tyakht
Moscow Institute of Physics and Technology (MIPT), 9 Institutskiy per, Dolgoprudny, Moscow Region, Russian Federation.|Federal Research and Clinical Centre of Physical-Chemical Medicine (FRCC PCM), Malaya Pirogovskaya 1a, Moscow, Russian Federation.
Dmitry G
DG
Alexeev
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D006801:Humans; D054892:Metagenome; D064307:Microbiota / Q000187:drug effects*; D012984:Software
D000900:Anti-Bacterial Agents