Effects of ritonavir and cobicistat on dolutegravir exposure: when the booster can make the difference.
Department of Infectious Diseases, L. Sacco University Hospital, Milan, Italy.
Cristina
C
Gervasoni
Department of Infectious Diseases, L. Sacco University Hospital, Milan, Italy.
Agostino
A
Riva
Unit of Clinical Pharmacology, L. Sacco University Hospital, Milan, Italy.
Valeria
V
Cozzi
Department of Infectious Diseases, L. Sacco University Hospital, Milan, Italy.
Amedeo
A
Capetti
Department of Infectious Diseases, L. Sacco University Hospital, Milan, Italy.
Giuliano
G
Rizzardini
Clinical Pharmacology Unit, Department Biomedical and Clinical Sciences, CNR Institute of Neuroscience, L. Sacco University Hospital, Università di Milano, Milan, Italy.|Scientific Institute IRCCS E.Medea, Bosisio Parini 23842, Italy.
Emilio
E
Clementi
Unit of Clinical Pharmacology, L. Sacco University Hospital, Milan, Italy.
Dario
D
Cattaneo
D019380:Anti-HIV Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000069547:Cobicistat / Q000493:pharmacokinetics* / Q000627:therapeutic use; D065692:Cytochrome P-450 CYP3A Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000069454:Darunavir / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D019428:HIV Integrase Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017320:HIV Protease Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015497:HIV-1 / Q000187:drug effects; D006575:Heterocyclic Compounds, 3-Ring / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010078:Oxazines; D010879:Piperazines; D011728:Pyridones; D019438:Ritonavir / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000099226:Dolutegravir
D019380:Anti-HIV Agents; D000069547:Cobicistat; D065692:Cytochrome P-450 CYP3A Inhibitors; D000069454:Darunavir; D019428:HIV Integrase Inhibitors; D017320:HIV Protease Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D010078:Oxazines; D010879:Piperazines; D011728:Pyridones; D019438:Ritonavir; D000099226:Dolutegravir