pH responsive controlled release of anti-cancer hydrophobic drugs from sodium alginate and hydroxyapatite bi-coated iron oxide nanoparticles.
Developing a drug carrier system which could perform targeted and controlled release over a period of time is utmost concern in the pharmaceutical industry. This is more relevant when designing drug carriers for poorly water soluble drug molecules such as curcumin and 6-gingerol. Development of a drug carrier system which could overcome these limitations and perform controlled and targeted drug delivery is beneficial. This study describes a promising approach for the design of novel pH sensitive sodium alginate, hydroxyapatite bilayer coated iron oxide nanoparticle composite (IONP/HAp-NaAlg) via the co-precipitation approach. This system consists of a magnetic core for targeting and a NaAlg/HAp coating on the surface to accommodate the drug molecules. The nanocomposite was characterized using FT-IR spectroscopy, X-ray diffraction, scanning electron microscopy, transmission electron microscopy and thermogravimetric analysis. The loading efficiency and loading capacity of curcumin and 6-gingerol were examined. In vitro drug releasing behavior of curcumin and 6-gingerol was studied at pH 7.4 and pH 5.3 over a period of seven days at 37°C. The mechanism of drug release from the nanocomposite of each situation was studied using kinetic models and the results implied that, the release is typically via diffusion and a higher release was observed at pH 5.3. This bilayer coated system can be recognized as a potential drug delivery system for the purpose of curcumin and 6-gingerol release in targeted and controlled manner to treat diseases such as cancer.
Department of Chemistry, University of Colombo, Colombo 03, Sri Lanka.
Danushika C
DC
Manatunga
Department of Chemistry, University of Colombo, Colombo 03, Sri Lanka. Electronic address: rohini@chem.cmb.ac.lk.
Rohini M
RM
de Silva
Department of Chemistry, University of Colombo, Colombo 03, Sri Lanka; Sri Lanka Institute of Nanotechnology (SLINTEC), Nanotechnology & Science Park, Mahenwatte, Pitipana, Homagama, Sri Lanka.
K M Nalin
KMN
de Silva
Sri Lanka Institute of Nanotechnology (SLINTEC), Nanotechnology & Science Park, Mahenwatte, Pitipana, Homagama, Sri Lanka.
Nuwan
N
de Silva
Department of Physics, Michigan Technological University, 118 Fisher Hall, 1400 Townsend Drive, Houghton, USA.
Shiva
S
Bhandari
Department of Physics, Michigan Technological University, 118 Fisher Hall, 1400 Townsend Drive, Houghton, USA.
Yoke Khin
YK
Yap
Ratnapura General Hospital, Colombo Road, Ratnapura, Sri Lanka.
N Pabakara
NP
Costha
D000464:Alginates / Q000032:analysis / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000032:analysis / Q000737:chemistry*; D002396:Catechols / Q000032:analysis / Q000737:chemistry; D003474:Curcumin / Q000032:analysis / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000032:analysis / Q000737:chemistry; D004337:Drug Carriers / Q000032:analysis / Q000737:chemistry; D065546:Drug Liberation; D017886:Durapatite / Q000032:analysis / Q000737:chemistry*; D005233:Fatty Alcohols / Q000032:analysis / Q000737:chemistry; D005290:Ferric Compounds / Q000032:analysis / Q000737:chemistry*; D020723:Glucuronic Acid / Q000032:analysis / Q000737:chemistry; D006603:Hexuronic Acids / Q000032:analysis / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D053768:Metal Nanoparticles / Q000032:analysis / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000032:analysis / Q000737:chemistry; D014961:X-Ray Diffraction / Q000379:methods
D000464:Alginates; D000970:Antineoplastic Agents; D002396:Catechols; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005233:Fatty Alcohols; D005290:Ferric Compounds; D006603:Hexuronic Acids; C000499:ferric oxide; D011092:Polyethylene Glycols; D020723:Glucuronic Acid; D017886:Durapatite; C007845:gingerol; D003474:Curcumin
6-Gingerol; Alginic acid sodium salt (PubChem CID: 5102882); Ammonium iron (II) sulfate hexahydrate (PubChem CID: 16211143); Ammonium iron (III) sulfate dodecahydrate (PubChem CID: 16211144); Calcium nitrate tetra hydrate (PubChem CID: 16211656); Controlled release; Curcumin; Curcumin (PubChem CID: 969516); Diammonium hydrogen phosphate (PubChem CID: 24540); Hydroxyapatite; Magnetic Fe(3)O(4); Sodium alginate; [6]-Gingerol (PubChem CID: 442793)