Modulation of AβPP and GSK3β by Endoplasmic Reticulum Stress and Involvement in Alzheimer's Disease.
Alzheimer's disease (AD) is a dementia disease with neuronal loss and synaptic impairment. This impairment is caused, at least partly, by the generation of two main AD hallmarks, namely the hyperphosphorylated tau protein comprising neurofibrillary tangles and senile plaques containing amyloid-β (Aβ) peptides. The amyloid-β protein precursor (AβPP) and glycogen synthase kinase-3β (GSK3β) are two main proteins associated with AD and are closely correlated with these hallmarks. Recently, both of the proteins were reported to be modulated by endoplasmic reticulum stress (ERS) and are involved in the pathogenesis of AD. The mechanism of ERS plus the modulation of AβPP processing and GSK3β activity by ERS in AD are summarized and explored in this review.
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, P.R. China.|College of Arts and Science of Beijing Union University, Beijing, P.R. China.
Xin-Jun
XJ
Liu
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, P.R. China.|College of Arts and Science of Beijing Union University, Beijing, P.R. China.
Jun
J
Wei
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, P.R. China.|College of Arts and Science of Beijing Union University, Beijing, P.R. China.
Ying-Hui
YH
Shang
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, P.R. China.|College of Arts and Science of Beijing Union University, Beijing, P.R. China.
Han-Chang
HC
Huang
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, P.R. China.|College of Arts and Science of Beijing Union University, Beijing, P.R. China.
Feng-Xue
FX
Lao
D000544:Alzheimer Disease / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D000071679:Glycogen Synthase Kinase 3 beta / Q000378:metabolism*; D006801:Humans
D016564:Amyloid beta-Protein Precursor; D000071679:Glycogen Synthase Kinase 3 beta
Alzheimer’s disease; amyloid-β; apoptosis; endoplasmic reticulum stress; neurofibrillary tangles