Bioapplications of Electrochemical Sensors and Biosensors.
Recent progress in the electrochemical field enabled development of miniaturized sensing devices that can be used in biological settings to obtain fundamental and practical biochemically relevant information on physiology, metabolism, and disease states in living systems. Electrochemical sensors and biosensors have demonstrated potential for rapid, real-time measurements of biologically relevant molecules. This chapter provides an overview of the most recent advances in the development of miniaturized sensors for biological investigations in living systems, with focus on the detection of neurotransmitters and oxidative stress markers. The design of electrochemical (bio)sensors, including their detection mechanism and functionality in biological systems, is described as well as their advantages and limitations. Application of these sensors to studies in live cells, embryonic development, and rodent models is discussed.
Clarkson University, Clarkson, NY, United States.
Eduard
E
Dumitrescu
Clarkson University, Clarkson, NY, United States. Electronic address: eandrees@clarkson.edu.
Silvana
S
Andreescu
D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D008839:Microelectrodes; D018377:Neurotransmitter Agents / Q000032:analysis; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000032:analysis; D059010:Single-Cell Analysis / Q000295:instrumentation / Q000379:methods
D018377:Neurotransmitter Agents; D017382:Reactive Oxygen Species
Electrochemical detection; Electrochemical sensors; In vivo electrochemistry; Neurotransmitters; Oxidative stress; RNS; ROS; Single cell