Case report - atypical hemolytic uremic syndrome triggered by influenza B.
BACKGROUND
Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, influenza B has not been reported to trigger aHUS.


METHODS
A 6-month-old boy presented with hemolytic uremic syndrome triggered by influenza B infection. Initially the child recovered spontaneously. When he relapsed Eculizumab treatment was initiated, resulting in complete and sustained remission. A pathogenic mutation in membrane cofactor protein (MCP) was detected.


CONCLUSIONS
Influenza B is a trigger for aHUS and might be underreported as such. Influenza vaccination may protect patients at risk.
University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246, Hamburg, Germany. r.kobbe@uke.de.
Robin
R
Kobbe
University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246, Hamburg, Germany.
Raphael
R
Schild
University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246, Hamburg, Germany.
Martin
M
Christner
University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246, Hamburg, Germany.
Jun
J
Oh
University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246, Hamburg, Germany.
Sebastian
S
Loos
University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246, Hamburg, Germany.
Markus J
MJ
Kemper
D065766:Atypical Hemolytic Uremic Syndrome / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D009981:Influenza B virus / Q000145:classification / Q000302:isolation & purification*; D007251:Influenza, Human / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D016896:Treatment Outcome
Atypical HUS; HUS; Hemolytic uremic syndrome; Influenza; Influenza vaccination; Quadrivalent; aHUS