Follicular output rate can predict clinical pregnancy in women with unexplained infertility undergoing IVF/ICSI: a prospective cohort study.
This study aimed to determine whether follicular output rate (FORT) can predict the clinical pregnancy rate in women with unexplained infertility undergoing IVF/ICSI. This was a prospective study conducted at Dar El Teb subfertility centre in Cairo between June 2014 and July 2016. A total of 303 women with unexplained infertility, who were undergoing IVF/ICSI, were divided into three groups according to FORT tertile values. FORT was calculated as pre-ovulatory follicle count/antral follicle count × 100. There was a progressive and significant increase from the low to the high FORT groups in the clinical pregnancy rate (29.9%, 43.3% and 57.8%; P < 0.001), number of retrieved oocytes (5.4 ± 1.5, versus 6.8 ± 2.8, and 7.4 ± 2.1; P < 0.001), and fertilization rate (48.4 ± 21.8 versus 55.3 ± 20.3 and 57.4 ± 19.2; P = 0.006). Multivariate logistic regression analysis revealed that the correlation between FORT and pregnancy was independent of potential confounding factors (P = 0.008). We concluded that FORT is an independent variable affecting the clinical pregnancy rate in IVF/ICSI cycles. Higher FORT values had better oocyte yield and clinical pregnancy rates in women with unexplained infertility undergoing IVF/ICSI with potentially normal ovarian response.
Department of Gynecology and Obstetrics, Cairo University, 1 Alsaraya Street, AlKasr AlAiny, Cairo 11562, Egypt. Electronic address: abdelgany2@gmail.com.
A
A
Hassan
Department of Gynecology and Obstetrics, Cairo University, 1 Alsaraya Street, AlKasr AlAiny, Cairo 11562, Egypt.
M
M
Kotb
Department of Gynecology and Obstetrics, Ain Shams University, Ramsis Street, Abassiya, Cairo 1156, Egypt.
A
A
AwadAllah
Department of Gynecology and Obstetrics, Cairo University, 1 Alsaraya Street, AlKasr AlAiny, Cairo 11562, Egypt.
A
A
Wahba
Department of Gynecology and Obstetrics, Beni Suef University, Beni Suef Governorate, Egypt.
N
N
Shehata
D000328:Adult; D006063:Chorionic Gonadotropin; D005260:Female; D006801:Humans; D007246:Infertility; D008297:Male; D006080:Ovarian Follicle; D010062:Ovulation Induction / Q000706:statistics & numerical data*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic; D055815:Young Adult
D006063:Chorionic Gonadotropin
FORT; ICSI; IVF; Ovarian response; Unexplained infertility