'APAAN in the neck' - A reflection on some novel impurities found in seized materials containing amphetamine in Ireland during routine forensic analysis.
This perspective examines amphetamine importations into Ireland. Some novel by-products were detected and linked to a change in the method of production of P2P from APAAN. These by-products remained present during subsequent Leuckart reaction conditions. Novel by-products from substituted cathinone synthesis reactions were also isolated and characterized.
Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, D08W9RT, Ireland.|Forensic Science Ireland, Garda HQ, Phoenix Park, Dublin 8, D08HN3X, Ireland.
John D
http://orcid.org/0000-0003-0926-1621
JD
Power
Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, D08W9RT, Ireland.
Pierce
P
Kavanagh
Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, D08W9RT, Ireland.
Gavin
http://orcid.org/0000-0002-2496-8396
G
McLaughlin
Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, D08W9RT, Ireland.
Michael
M
Barry
Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, D08W9RT, Ireland.|School of Chemical and Pharmaceutical Sciences, College of Sciences and Health, Dublin Institute of Technology, Kevin Street, Dublin 8, D08NF82, Ireland.
Geraldine
G
Dowling
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, L3 3AF, Liverpool, UK.
Simon D
http://orcid.org/0000-0001-8632-5372
SD
Brandt
D000096:Acetone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000097:Acetonitriles / Q000138:chemical synthesis / Q000737:chemistry*; D000661:Amphetamine / Q000138:chemical synthesis / Q000737:chemistry*; D000697:Central Nervous System Stimulants / Q000138:chemical synthesis / Q000737:chemistry*; D004340:Drug Contamination; D008401:Gas Chromatography-Mass Spectrometry; D006868:Hydrolysis; D013287:Illicit Drugs / Q000138:chemical synthesis / Q000737:chemistry*; D007494:Ireland; D010604:Pharmacy
D000097:Acetonitriles; D000697:Central Nervous System Stimulants; D013287:Illicit Drugs; D000096:Acetone; C006725:benzyl cyanide; D000661:Amphetamine; C008863:1-phenyl-2-propanone
APAAN; amphetamine; by-products; importations; synthesis