Soluble CD93 in Serum as a Marker of Allergic Inflammation.
OBJECTIVE
CD93 is receiving renewed attention as a biomarker of inflammation. We aimed to evaluate the potential for serum sCD93 to serve as a novel biomarker for allergic inflammation.


METHODS
We enrolled 348 subjects with an allergic disease [allergic rhinitis (AR), chronic spontaneous urticaria (CSU), or bronchial asthma (BA)], including 14 steroid-naïve BA patients who were serially followed-up.


RESULTS
The serum sCD93 levels (ng/mL) in patients with exacerbated AR (mean±standard deviation, 153.1±58.4) were significantly higher than in patients without AR (132.2±49.0) or with stable AR (122.3±42.1). Serum sCD93 levels in exacerbated CSU (169.5±42.8) were also significantly higher than those in non-CSU (132.4±51.6) and stable CSU (122.8±36.2). This trend was also seen in BA. Serum levels in patients with ICS-naïve BA (161.4±53.1) were significantly higher than those in healthy controls without BA (112.2±30.8), low- and medium-dose ICS users. Serum sCD93 levels in high-dose ICS users (72.2±20.6) were significantly lower than those in low- and medium-dose users. The serum sCD93 levels in steroid-naïve patients with BA (195.1±72.7) decreased after ICS use for 4 weeks (134.4±42.8) and 8 weeks (100.7±13.4), serially.


CONCLUSIONS
Elevated serum sCD93 levels reflected exacerbated status of allergic diseases, including CSU, AR, and asthma. ICS use significantly diminished serum sCD93 levels in steroid-naïve patients with BA. This result may suggest sCD93 in serum as a therapeutic marker for allergic inflammation.
Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Hye Jung
HJ
Park
Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
Heejae
H
Han
Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.|Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Sang Chul
SC
Lee
Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.|Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Young Woong
YW
Son
Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.|Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Da Woon
DW
Sim
Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.|Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Kyung Hee
KH
Park
Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
Yoon Hee
YH
Park
Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
Kyoung Yong
KY
Jeong
Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.|Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Jung Won
JW
Park
Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.|Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. jhleemd@yuhs.ac.
Jae Hyun
JH
Lee
D000328:Adult; D001249:Asthma / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis; D008562:Membrane Glycoproteins / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D011951:Receptors, Complement / Q000097:blood* / Q000378:metabolism; D065631:Rhinitis, Allergic / Q000097:blood* / Q000276:immunology; D014581:Urticaria / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D055815:Young Adult
D015415:Biomarkers; D008562:Membrane Glycoproteins; D011951:Receptors, Complement; C032402:complement 1q receptor
Allergy; asthma; biomarker; inhaled corticosteroid; soluble CD93