Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks.
BACKGROUND
We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status.


RESULTS
In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07~2.31 and OR, 1.58; 95% CI, 1.04~2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65~11.01; p = 0.002), 2.34- (95% CI: 1.19~4.61; p = 0.01), and 2.34-fold (95% CI: 1.38~3.96; p = 0.001) higher risks of developing oral cancer.


CONCLUSIONS
Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.
Accelerated Bachelor of Science in Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.|School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
Hsiu-Ting
HT
Tsai
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.|Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan.|Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Ming-Ju
MJ
Hsieh
Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan.|Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chiao-Wen
CW
Lin
Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan.
Shih-Chi
SC
Su
Accelerated Bachelor of Science in Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
Nae-Fang
NF
Miao
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.|Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
Shun-Fa
SF
Yang
Accelerated Bachelor of Science in Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
Hui-Chuan
HC
Huang
Accelerated Bachelor of Science in Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
Fu-Chih
FC
Lai
Department of Biomedical Sciences, College of Medicine Sciences and Technology, Chung Shan Medical University, Taichung, Taiwan.|Division of Allergy, Department of Pediatrics, Chung-Shan Medical University Hospital, Taichung, Taiwan.
Yu-Fan
YF
Liu
D000428:Alcohol Drinking / Q000009:adverse effects*; D000483:Alleles; D001114:Areca / Q000009:adverse effects*; D016022:Case-Control Studies; D005787:Gene Frequency; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D009062:Mouth Neoplasms / Q000209:etiology* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D015843:Serpins / Q000235:genetics*; D012907:Smoking / Q000009:adverse effects*
C085344:SERPIN-B5; D015843:Serpins