Nutritional parameters and carbohydrate and fat metabolism after prolonged salsolinol administration in rats fed normal or high-fat diets.
OBJECTIVE
Previous studies have reported that exogenous salsolinol might contribute to myenteric cell death and altered gastrointestinal motility. Because the entire gut mucosal, entero-endocrine and motor functions are integrated by the enteric nervous system, the aim of the present study was to investigate if prolonged intraperitoneal salsolinol administration alters basic metabolism and nutritional parameters in adult Wistar rats fed normal or high-fat diets.


METHODS
Male Wistar rats were subjected to continuous intraperitoneal low dosing of salsolinol with ALZET osmotic mini-pumps for 2 or 4 weeks and fed either a normal or high-fat diet. Appropriate groups served as the controls. Nutritional status (food intake, body weight, and epididymal fat pads weight), residual solid food in the stomach and biochemical parameters (GIP, GLP-1, CRF, glucose, TG, LDL, HDL) were assessed.


RESULTS
Prolonged salsolinol treatment significantly reduced total body mass and adipose tissue accumulation. The effects were more pronounced in the salsolinol-treated rats fed a high-fat diet. In salsolinol-treated rats, serum postprandial GIP levels were elevated, and serum postprandial GLP-1 levels were lower compared with the appropriate controls.


CONCLUSIONS
Salsolinol might influence the regulatory mechanisms of body weight and epididymal fat pad accumulation through neurohormonal pathways.
Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland.
Magdalena
M
Kurnik-Lucka
Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland.
Krzysztof
K
Gil
Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland.
Andrzej
A
Bugajski
Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland.
Agata
A
Furgała
Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland.
Piotr
P
Thor
D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D050260:Carbohydrate Metabolism / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000378:metabolism*; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D007546:Isoquinolines / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009752:Nutritional Status; D017208:Rats, Wistar
D004041:Dietary Fats; D007546:Isoquinolines; C036617:salsolinol