The Epitranscriptome of Noncoding RNAs in Cancer.
The activity of RNA is controlled by different types of post-transcriptional modifications, such as the addition of methyl groups and other chemical and structural changes, that have been recently described in human cells by high-throughput sequencing. Herein, we will discuss how the so-called epitranscriptome is disrupted in cancer and what the contribution of its writers, readers, and erasers to the process of cellular transformation is, particularly focusing on the epigenetic modifications of ncRNAs.Significance:Chemical modifications of RNA play a central role in the control of messenger and ncRNA activity and, thus, are tightly regulated in cells. In this review, we provide insight into how these marks are altered in cancer cells and how this knowledge can be translated to the clinical setting.Cancer Discov; 7(4); 359-68. ©2017 AACR.
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain. ppandolf@bidmc.harvard.edu mesteller@idibell.cat.|Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.|Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Catalonia, Spain.
Manel
M
Esteller
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. ppandolf@bidmc.harvard.edu mesteller@idibell.cat.
Pier Paolo
PP
Pandolfi
D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D044127:Epigenesis, Genetic; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D022661:RNA, Untranslated / Q000235:genetics*; D059467:Transcriptome / Q000235:genetics*
D022661:RNA, Untranslated