Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya.
One hundred healthy infants enrolled as controls in a tuberculosis vaccine study in Nyanza Province, Kenya provided anonymized samples for DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci. The purpose of the study was to characterize allele frequencies in the local population, to support studies of T cell immunity against pathogens, including Mycobacterium tuberculosis. There are no detectable deviations from Hardy Weinberg proportions for the HLA-B, -C, -DRB1, -DPB1, -DQA1 and -DQB1 loci. A minor deviation was detected at the HLA-A locus due to an excess of HLA-A*02:02, 29:02, 30:02, and 68:02 homozygotes. The genotype data are available in the Allele Frequencies Net Database under identifier 3393.
Division of Vaccine Discovery, La Jolla Institute for Allergy & Immunology (LJI), La Jolla, CA 92037, USA; TBRU-ASTRa, USA.
Cecilia S Lindestam
CS
Arlehamn
Division of Infectious Diseases and Immunology, New York University School of Medicine, New York, NY 10016, USA.
Richard
R
Copin
Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia.
Shay
S
Leary
Children's Hospital Oakland Research Institute, Oakland, CA, USA.
Steven J
SJ
Mack
Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia; Vanderbilt University School of Medicine, Nashville, TN 37235, USA.
Elizabeth
E
Phillips
Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia; Vanderbilt University School of Medicine, Nashville, TN 37235, USA.
Simon
S
Mallal
Division of Vaccine Discovery, La Jolla Institute for Allergy & Immunology (LJI), La Jolla, CA 92037, USA; TBRU-ASTRa, USA.
Alessandro
A
Sette
Aeras, Rockville, MD 20850, USA; TBRU-ASTRa, USA.
Gretta
G
Blatner
Aeras, Rockville, MD 20850, USA; TBRU-ASTRa, USA.
Heather
H
Siefers
Division of Infectious Diseases and Immunology, New York University School of Medicine, New York, NY 10016, USA; TBRU-ASTRa, USA. Electronic address: joel.ernst@med.nyu.edu.
Joel D
JD
Ernst
D030561:Databases, Nucleic Acid; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D007223:Infant; D007630:Kenya; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
D006680:HLA Antigens
HLA alleles; Kenya; Luo