Regioselective synthesis of C3 alkylated and arylated benzothiophenes.
Benzothiophenes are heterocyclic constituents of important molecules relevant to society, including those with the potential to meet modern medical challenges. The construction of molecules would be vastly more efficient if carbon-hydrogen bonds, found in all organic molecules, can be directly converted into carbon-carbon bonds. In the case of elaborating benzothiophenes, functionalization of carbon-hydrogen bonds at carbon-number 3 (C3) is markedly more demanding than at C2 due to issues of regioselectivity (C3 versus C2), and the requirement of high temperatures, precious metals and the installation of superfluous directing groups. Herein, we demonstrate that synthetically unexplored but readily accessible benzothiophene S-oxides serve as novel precursors for C3-functionalized benzothiophenes. Employing an interrupted Pummerer reaction to capture and then deliver phenol and silane coupling partners, we have discovered a directing group-free method that delivers C3-arylated and -alkylated benzothiophenes with complete regioselectivity, under metal-free and mild conditions.
School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Harry J
HJ
Shrives
School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
José A
JA
Fernández-Salas
School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Christin
C
Hedtke
School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Alexander P
0000-0003-1754-527X
AP
Pulis
School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
David J
DJ
Procter