Synthesis of pyrrolo[1,2-a]naphthyridines by Lewis acid mediated cycloisomerization.
Pyrrolo[1,2-a]naphthyridines were synthesized from 3-alkynyl-2-([1H]-pyrrol-1-yl)pyridines and 3-alkynyl-4-([1H]-pyrrol-1-yl)pyridines by cycloisomerization. The reactions are performed by application of the Lewis acids PtCl2or Bi(OTf)3without the need of further additives. With the described methods a number of derivatives containing a variety of functional groups have been synthesized in up to 78% yield.
Universität Rostock, Institut für Chemie, Albert-Einstein-Str. 3a, 18059 Rostock, Germany. peter.langer@uni-rostock.de.
Anika
A
Flader
Silvio
S
Parpart
Peter
P
Ehlers
Peter
P
Langer