Clinical significance of NDRG3 in patients with breast cancer.
OBJECTIVE
The expression level of NDRG3 gene is investigated among breast cancer (BC) patients.


METHODS
Real-time quantitative PCR was performed.


RESULTS
NDRG3 was downregulated in BC patients particularly in advanced stage of the disease. HER2 status was significantly correlated with the expression of NDRG3. Also, triple-negative BC patients showed low levels of NDRG3 expression in comparison to other subtypes. Lastly, the expression of NDRG3 had significant impact on survival, with NDRG3 downregulated patients having the worst event-free survival rate among others.


CONCLUSIONS
We have presented that NDRG3 might be a tumor suppressor candidate. NDRG3 downregulation might be involved in the tumorigenesis and development of invasive BC in an advanced phase of the disease.
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mehrdad Asghari
MA
Estiar
Recombinant Proteins Department, Breast Cancer Research Center, ACECR, Tehran, Iran.
Ali-Akbar
AA
Zare
Cancer Genetics Department, Breast Cancer Research Center, ACECR, Tehran, Iran.
Rezvan
R
Esmaeili
Cancer Genetics Department, Breast Cancer Research Center, ACECR, Tehran, Iran.
Leila
L
Farahmand
Developmental Neurobiology, Instituto de Neurociencias UMH-SIC, Alicante, Spain.
Hassan
H
Fazilaty
Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Davood
D
Jafari
Cancer Genetics Department, Breast Cancer Research Center, ACECR, Tehran, Iran.
Tannaz
T
Samadi
Cancer Genetics Department, Breast Cancer Research Center, ACECR, Tehran, Iran.
Keivan
K
Majidzadeh-A
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality*; D016022:Case-Control Studies; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D055815:Young Adult
D014408:Biomarkers, Tumor; D047908:Intracellular Signaling Peptides and Proteins; C431706:NDRG3 protein, human; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger
MYC; NDRG; breast cancer