Pd-Catalyzed Direct ortho-C-H Arylation of Aromatic Ketones Enabled by a Transient Directing Group.
The Pd-catalyzed direct C(sp2)-H arylation of aromatic ketones using a transient directing group is described. The ketimine/carboxylate bidentate directing group in situ generated from aromatic ketone and glycine enabled a palladium-catalyzed ortho-C-H arylation, which shows extensive substrate compatibility.
State Key Laboratory and Institute of Elemento-organic Chemistry, School of Chemistry, Nankai University , Tianjin 300071, China.
Jiancong
J
Xu
State Key Laboratory and Institute of Elemento-organic Chemistry, School of Chemistry, Nankai University , Tianjin 300071, China.
Yang
Y
Liu
State Key Laboratory and Institute of Elemento-organic Chemistry, School of Chemistry, Nankai University , Tianjin 300071, China.
Ying
Y
Wang
State Key Laboratory and Institute of Elemento-organic Chemistry, School of Chemistry, Nankai University , Tianjin 300071, China.
Yajuan
Y
Li
State Key Laboratory and Institute of Elemento-organic Chemistry, School of Chemistry, Nankai University , Tianjin 300071, China.
Xiaohua
X
Xu
State Key Laboratory and Institute of Elemento-organic Chemistry, School of Chemistry, Nankai University , Tianjin 300071, China.
Zhong
0000-0001-5722-7175
Z
Jin