Facile Access to Multisensitive and Self-Healing Hydrogels with Reversible and Dynamic Boronic Ester and Disulfide Linkages.
Multifunctional and multiresponsive hydrogels have presented a promising platform to design and fabricate smart devices for application in a wide variety of fields. However, their preparations often involve multistep preparation of multiresponsive polymer precursors, tedious reactions to introduce functional groups or sophisticated molecular designs. In this work, a multifunctional boronic acid-based cross-linker bis(phenylboronic acid carbamoyl) cystamine (BPBAC) was readily prepared from inexpensive commercially available 3-carboxylphenylboronic acid (CPBA) and cystamine dihydrochloride, which has the ability to cross-link the cis-diols and catechol-containing hydrophilic polymers to form hydrogels. Due to the presence of the reversible and dynamic boronate ester and disulfide bonds, the obtained hydrogels were demonstrated to not only possess pH, glucose, and redox triresponsive features, but also have autonomic self-healing properties under ambient conditions. Moreover, we can modulate the rheological and mechanical properties by simply adjusting the BPBAC amount. The features, such as commercially available starting materials, easy-to-implement approach, and versatility in controlling cross-linking network and mechanical properties, make the strategy described here a promising platform for fabricating multifunctional and smart hydrogels.
State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research Institute (LSMRI) , Qingdao 266101, China.
Ruiwei
R
Guo
Qian
Q
Su
State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research Institute (LSMRI) , Qingdao 266101, China.
Jinwei
J
Zhang
Collaborative Innovation Center of Chemical Science and Engineering , Tianjin 300072, China.
Anjie
A
Dong
State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research Institute (LSMRI) , Qingdao 266101, China.
Cunguo
C
Lin
Jianhua
0000-0001-7833-9715
J
Zhang
D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry*; D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002396:Catechols / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003538:Cystamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D004220:Disulfides / Q000737:chemistry*; D004229:Dithiothreitol / Q000737:chemistry; D004298:Dopamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry*; D010084:Oxidation-Reduction; D044367:Phase Transition; D013499:Surface Properties
D000180:Acrylic Resins; D001897:Boronic Acids; D002396:Catechols; D003432:Cross-Linking Reagents; D004220:Disulfides; D020100:Hydrogels; C000624487:bis(phenylboronic acid carbamoyl)cystamine; C000624438:poly(acrylamide-co-dopamine methacrylamide); D005947:Glucose; C034221:catechol; D003538:Cystamine; D004229:Dithiothreitol; D004298:Dopamine