A novel framework for understanding reduced awareness of dyskinesias in Parkinson's Disease.
Although dyskinesias-reduced-self-awareness (DRSA) in Parkinson's disease (PD) is related to deficit in metacognition, other factors, such as "Theory of Mind" (ToM), could operate.



Forty-one PD patients were assessed using the Global Awareness of Movement Disorders (GAM) and the Dyskinesias Subtracted-Index (DS-I). To study whether GAM and DS-I scores could be influenced by second-type ToM or Reading the Mind in the Eyes (RME) tasks, we conducted two multiple logistic regression analyses.



The association between the GAM, the DS-I and RME task were highly significant. The association between DS-I and Trail Making Test B-A version was also verified.



DRSA was related with affective component of ToM and executive functions, thus caused by a complex interplay between specific neuropsychological and motor factors.
Department of Neuroscience, Via Cherasco 15, 10126 Turin, Italy.
Sara
S
Palermo
Department of Neuroscience, Via Cherasco 15, 10126 Turin, Italy; Centro Interdipartimentale di Studi Avanzati in Neuroscienze - National Institute of Turin (NIT), Regione Gonzole 10, 10043 Orbassano, Italy.
Leonardo
L
Lopiano
Department of Neuroscience, Via Cherasco 15, 10126 Turin, Italy.
Maurizio
M
Zibetti
Department of Psychology, University of Turin, Via Verdi 10, 10123 Turin, Italy; Cancer Epidemiology Unit, "Città della Salute e della Scienza" Hospital, Turin, Italy.
Rosalba
R
Rosato
Martini Hospital, Via Tofane 71, 10141 Turin, Italy.
Daniela
D
Leotta
Centro Interdipartimentale di Studi Avanzati in Neuroscienze - National Institute of Turin (NIT), Regione Gonzole 10, 10043 Orbassano, Italy; Department of Psychology, University of Turin, Via Verdi 10, 10123 Turin, Italy. Electronic address: martina.amanzio@unito.it.
Martina
M
Amanzio
D000368:Aged; D001364:Awareness / Q000502:physiology*; D004409:Dyskinesia, Drug-Induced / Q000209:etiology / Q000523:psychology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D056345:Theory of Mind / Q000502:physiology*
D007980:Levodopa
Dyskinesias; Parkinson's disease; Reading the Mind in the Eyes; Self-awareness; Theory of Mind