Parent of Origin and Prognosis in Familial Breast Cancer in Sweden.
It has been suggested that prognosis in familial breast cancer could be influenced by the parent of origin, with a worse prognosis when inherited paternally. This study aimed to investigate the effect of the parent of origin on prognosis.



Index patients were divided into two study groups depending on the parent of origin. Tumour characteristics and survival data for index patients were collected.



In total, 319 families fulfilled the inclusion criteria. No significant difference in overall or recurrence-free survival between those with maternal and those with paternal inheritance was observed, with hazard ratios (HR) of 0.99 (95% confidence interval (CI)=0.54 to 1.80, p=0.97) and 1.22 (95% CI=0.78 to 1.92, p=0.38), respectively.



We found no evidence for a worse prognosis in patients with paternally inherited breast cancer. However, only large differences in prognosis were excluded and the tendency for worse recurrence-free survival in the group with paternal inheritance therefore merits further study.
Department of Oncology-Pathology, Karolinska Institute Solna, Stockholm, Sweden camilla.wendt@sll.se.|Department of Oncology, Sodersjukhuset, Stockholm, Sweden.
Camilla
C
Wendt
Department of Molecular Medicine and Surgery, Karolinska Institute Solna, Stockholm, Sweden.|Department of Clinical Genetics, Karolinska University Hospital Solna, Stockholm, Sweden.
Annika
A
Lindblom
Department of Oncology-Pathology, Karolinska Institute Solna, Stockholm, Sweden.|Department of Oncology, Karolinska University Hospital Solna, Stockholm, Sweden.
Brita
B
Arver
Department of Oncology-Pathology, Karolinska Institute Solna, Stockholm, Sweden.|Department of Oncology, Sodersjukhuset, Stockholm, Sweden.
Anna
A
VON Wachenfeldt
Department of Oncology-Pathology, Karolinska Institute Solna, Stockholm, Sweden.|Department of Oncology, Sodersjukhuset, Stockholm, Sweden.
Sara
S
Margolin
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000208:ethnology / Q000401:mortality; D015331:Cohort Studies; D018572:Disease-Free Survival; D005192:Family Health; D005220:Fathers; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009035:Mothers; D011379:Prognosis; D016016:Proportional Hazards Models; D012306:Risk; D013548:Sweden
Breast cancer; genomic imprinting; inheritance; prognosis