Do External or Internal Factors Lead to Tumor Development? It Is Still Unknown.
Arguments supporting the "bad luck" hypothesis presented by C. Tomasetti and B. Vogelstein ((2015) Science, 347, 78-81) and A. V. Lichtenstein ((2017) Biochemistry (Moscow), 82, 75-80) are critically discussed. Those arguments are not sufficient for recognition of the "bad luck" hypothesis and the leading role of internal factors in spontaneous tumor development.
Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, 119991, Russia. manskikh@mail.ru.
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D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics* / Q000378:metabolism*