Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity.
Three new xanthones, oblongixanthone F-H (1-3), along with eight known xanthones (4-11), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated by spectroscopic analysis including 1D- and 2D-NMR spectroscopy and mass spectrometry. The antidiabetic effects of all isolated compounds were evaluated by in vitro α-glucosidase and PTP1B inhibition assays. Compound 11 was the most active compound, and inhibited α-glucosidase and PTP1B with IC50values of 1.7±0.5 and 14.1±3.5μM, respectively.
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark; Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, Ho Chi Minh City University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam.
Binh T D
BT
Trinh
Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, Ho Chi Minh City University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam.
Tam T T
TT
Quach
Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, Ho Chi Minh City University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam.
Dung N
DN
Bui
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark. Electronic address: ds@sund.ku.dk.
Dan
D
Staerk
Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, Ho Chi Minh City University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam. Electronic address: lienhoa-nguyen@vnn.vn.
Lien-Hoa D
LD
Nguyen
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark.
Anna K
AK
Jäger
D029760:Garcinia / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification; D000520:alpha-Glucosidases / Q000378:metabolism
D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D044004:Xanthones; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D000520:alpha-Glucosidases
Acarbose (PubChem CID: 444254); Cowagarcinone E (PubChem CID: 11421303); Cowanin (PubChem CID: 11754819); Cowanol (PubChem CID: 101671063); Garcinia oblongifolia; Norcowanin (PubChem CID: 11518330); Oblongixanthone C (PubChem CID: 25209204); PTP1B; RK682 (PubChem CID: 54678922); Rubraxanthone (PubChem CID: 9953366); Type 2 diabetes; Xanthones; α-Glucosidase