SCFAs Control Skin Immune Responses via Increasing Tregs.
We are surrounded by billions of microbes, and our immune system is substantially affected by the commensal bacteria on the surface of our body. Schwarz et al. describe the immune-suppressive effect of sodium butyrate, a bacterial metabolite that is categorized as one of the short-chain fatty acids, during skin inflammatory responses.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Gyohei
G
Egawa
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Tetsuya
T
Honda
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; PRESTO, Japan Science and Technology Agency, Saitama, Japan. Electronic address: kaba@kuhp.kyoto-u.ac.jp.
Kenji
K
Kabashima
D000287:Administration, Topical; D020148:Butyric Acid / Q000008:administration & dosage*; D003872:Dermatitis / Q000188:drug therapy / Q000276:immunology*; D005232:Fatty Acids, Volatile / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007377:Interleukin-3 / Q000378:metabolism*; D012680:Sensitivity and Specificity
D005232:Fatty Acids, Volatile; D007166:Immunosuppressive Agents; D007377:Interleukin-3; D020148:Butyric Acid