Targeted therapy of octreotide-modified oleanolic acid liposomes to somatostatin receptor overexpressing tumor cells.
To prepare and validate the efficacy of a novel targeted drug delivery system - octreotide (Oct)-modified oleanolic acid (OA) liposomes.



OA liposomes (OA-L) were prepared by an ethanol injection method. The Oct-modified OA liposomes (O-OA-L) were synthesized and their properties were evaluated. Cellular uptake and competition inhibition studies were performed.



The OA vesicles presented satisfactory particles size (100-200 nm), stability and drug release characteristics; their ζ potential was -1.42 ± 0.08 mV. The O-OA-L had a higher cell proliferation inhibitory activity and cellular uptake than that of OA-L for somatostatin receptor-positive A549 cells.



The O-OA-L, as a promising agent, can target actively the lesion site with safe and high-efficiency pattern.
Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China.|State Key Laboratory of Metastable Materials Science & Technology, Yanshan University, Qinhuangdao 066004, China.
Qianqian
Q
Wang
Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China.|Hebei Province Asparagus Industry Technology Research Institute, Qinhuangdao 066004, China.
Ruiyan
R
Zhu
Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China.
Meili
M
Wang
Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China.
Shanshan
S
Xing
Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China.
Lei
L
Li
Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China.
Yuchu
Y
He
Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China.
Weiwei
W
Cao
Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China.|State Key Laboratory of Metastable Materials Science & Technology, Yanshan University, Qinhuangdao 066004, China.
Dawei
D
Gao
D000072283:A549 Cells; D000818:Animals; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry*; D008175:Lung Neoplasms / Q000188:drug therapy*; D051379:Mice; D015282:Octreotide / Q000008:administration & dosage / Q000737:chemistry; D009828:Oleanolic Acid / Q000008:administration & dosage* / Q000737:chemistry; D017481:Receptors, Somatostatin / Q000096:biosynthesis; D023041:Xenograft Model Antitumor Assays
D008081:Liposomes; D017481:Receptors, Somatostatin; D009828:Oleanolic Acid; D015282:Octreotide
antitumor activity; octreotide; oleanolic acid; somatostatin receptor; targeting transportation