Treatment with 17β-Estradiol Reduced Body Weight and the Risk of Cardiovascular Disease in a High-Fat Diet-Induced Animal Model of Obesity.
Estrogen receptor α (ERα) and estrogen receptor β (ERβ) play important roles in cardiovascular disease (CVD) prevention. Recently, these estrogen receptors were reconsidered as an important treatment target of obesity leading to CVD. In this study, 17β-estradiol (17β-E) replacement therapy applied to high-fat diet-induced obese C57B male mice and ovariectomized (OVX) rats were evaluated, and the protective effects against high-fat diet-induced obesity were assessed in C57B mouse hearts. The results showed that 17β-E treatment activated both ERα and ERβ, and ERβ levels increased in a dose-dependent manner in high-fat diet C57B mouse cardiomyocytes following 17β-E treatment. Notably, an almost 16% reduction in body weight was observed in the 17β-E-treated (12 μg/kg/day for 60 days) high-fat diet-induced obese C57B male mice. These results suggested that 17β-E supplements may reduce CVD risk due to obesity.
The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, B24 Yinquan South Road, Qingyuan 511518, China. tim_sigeen@hotmail.com.|Graduate Institute of Basic Medical Science, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. tim_sigeen@hotmail.com.
Wei-Jen
WJ
Ting
Graduate Institute of Basic Medical Science, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. cyhuang@mail.cmu.edu.tw.|Graduate Institute of Chinese Medical Science, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. cyhuang@mail.cmu.edu.tw.|Department of Health and Nutrition Biotechnology, Asia University, 500 Lioufeng Road, Taichung 41354, Taiwan. cyhuang@mail.cmu.edu.tw.
Chih-Yang
CY
Huang
Department of Urology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, B24 Yinquan South Road, Qingyuan 511518, China. 00687@qyry.com.
Chong-He
CH
Jiang
Department of Pathology, Changhua Christian Hospital, 135 Nanxiao Street, Changhua 50006, Taiwan. 93668@cch.org.tw.|Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, 79-9 Sha-Luen Hu, Hou-Loung Town, Miaoli 35664, Taiwan. 93668@cch.org.tw.
Yueh-Min
YM
Lin
Department of Hospital and Health Care Administration, China Nan University of Pharmacy & Science, 60, Section 1, Erren Road, Rende District, Tainan 71710, Taiwan. alanjack@mail.cnu.edu.tw.
Li-Chin
LC
Chung
Department of Nursing, Mei Ho University, 23 Pingguang Road, Pingtung 91202, Taiwan. x00003061@meiho.edu.tw.
Chia-Yao
CY
Shen
Division of Cardiology, China Medical University Hospital, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. paidoctor1@gmail.com.
Peiying
P
Pai
Department of Emergency Medicine, China Medical University Hospital, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. cathyshibu@gmail.com.
Kuan-Ho
KH
Lin
Department of Biotechnology, Bharathiar University, Coimbatore 641046, India. padma.vijaya@gmail.com.
Vijaya Padma
VP
Viswanadha
School of Medicine, College of Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. liaosjay@gmail.com.
Shih-Chieh
SC
Liao
D000818:Animals; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D059305:Diet, High-Fat / Q000009:adverse effects; D004958:Estradiol / Q000627:therapeutic use*; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000150:complications / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000378:metabolism
D004967:Estrogens; D011960:Receptors, Estrogen; D004958:Estradiol
17β-estradiol; estrogen receptor α; estrogen receptor β; heart protection