Early onset of cardiometabolic risk factor profiles in drug naïve adolescents and young adults with first-episode schizophrenia.
We performed a case-control study, which included antipsychotic-naïve first-episode schizophrenia (FES) of adolescents and young adults and general population controls, to investigate the early-onset cardiometabolic risk factors in FES.



FES had more frequent lower HDL-C when compared to controls. However, the distribution of BMI and the frequency of hypercholesterolemia, elevated LDL-C, hypertriglyceridemia in FES were not significantly different to controls.



The results indicated that abnormal HDL-C might be an early-onset event in drug-naïve FES of adolescents and young adults who are unlikely to have other cardiometabolic risks.
Xinxiang Medical University, The Second Affiliated Hospital, Xinxiang 453002, China; Xinxiang Medical University, School of Public Health, Xinxiang 453003, China.
Desheng
D
Zhai
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China.
Yan
Y
Lang
Xinxiang Medical University, School of Pharmacy, Xinxiang 453003, China.
Yihang
Y
Feng
Xinxiang Medical University, School of Public Health, Xinxiang 453003, China.
Yijun
Y
Liu
Xinxiang Medical University, School of Pharmacy, Xinxiang 453003, China.
Gaopan
G
Dong
McLean Hospital & Harvard Medical School, USA.
Xin
X
Wang
McLean Hospital & Harvard Medical School, USA.
Ying
Y
Cao
Xinxiang Medical University, School of Pharmacy, Xinxiang 453003, China.
Taizhen
T
Cui
Xinxiang Medical University, School of Pharmacy, Xinxiang 453003, China.
Chenyang
C
Ni
Xinxiang Medical University, School of Pharmacy, Xinxiang 453003, China.
Yonggan
Y
Ji
Xinxiang Medical University, School of Pharmacy, Xinxiang 453003, China.
Xiaodan
X
Zhang
Xinxiang Medical University, School of Pharmacy, Xinxiang 453003, China; McLean Hospital & Harvard Medical School, USA. Electronic address: zhaoyingxxmc@163.com.
Ying
Y
Zhao
Xinxiang Medical University, The Second Affiliated Hospital, Xinxiang 453002, China. Electronic address: zhangruilingxx@163.com.
Ruiling
R
Zhang
D000208:Acute Disease; D000293:Adolescent; D017668:Age of Onset; D001786:Blood Glucose; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors; D012559:Schizophrenia / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D055815:Young Adult
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL
Cardiometabolic risk factor; Drug naïve; First-episode schizophrenia; High-density lipoprotein cholesterol (HDL-C)