Intracellular delivery of proteins by nanocarriers.
Intracellular delivery of proteins is potentially a game-changing approach for therapeutics. However, for most applications, the protein needs to access the cytosol to be effective. A wide variety of strategies have been developed for protein delivery, however access of delivered protein to the cytosol without acute cytotoxicity remains a critical issue. In this review we discuss recent trends in protein delivery using nanocarriers, focusing on the ability of these strategies to deliver protein into the cytosol.
Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA.
Moumita
M
Ray
Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA.
Yi-Wei
YW
Lee
Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA.
Federica
F
Scaletti
Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA.|College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
Ruijin
R
Yu
Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA.
Vincent M
VM
Rotello
D003593:Cytoplasm / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D053769:Nanocapsules / Q000737:chemistry / Q000627:therapeutic use*; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D011506:Proteins / Q000737:chemistry / Q000627:therapeutic use*
D004337:Drug Carriers; D053769:Nanocapsules; D011506:Proteins
cytosolic delivery; nanoparticle-stabilized nanocapsules; nuclear targeting; protein; punctate fluorescence