Statistical consequences of a successful lung allocation system - recovering information and reducing bias in models for urgency.
The lung allocation system has reduced the number of waitlist deaths by ranking transplant candidates on the basis of a lung allocation score that requires estimation of the current 1-year restricted mean waitlist survival (urgency). Fewer waitlist deaths and the systematic removal of candidates from the waitlist for transplantation present statistical challenges that must be addressed when using recent waitlist data. Multiple overlapping 1-year follow-up windows are used in a restricted mean model that estimates patient urgency on the basis of updated risk factors at the start of the window. In simulation studies, our proposed multiple imputation procedure was able to produce unbiased parameter estimates with similar efficiency to those obtained if censoring had never occurred. The analysis of 10,740 lung transplant candidates revealed that for most risk factors incorporating additional follow-up windows produced more efficient estimates. Copyright © 2017 John Wiley & Sons, Ltd.
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, U.S.A.
Nabihah
0000-0001-6088-167X
N
Tayob
Department of Biostatistics, University of Michigan, Ann Arbor, MI, U.S.A.
Susan
S
Murray
D000465:Algorithms; D015982:Bias; D056808:Biostatistics; D003198:Computer Simulation; D006801:Humans; D008171:Lung Diseases / Q000401:mortality / Q000601:surgery; D016040:Lung Transplantation / Q000706:statistics & numerical data*; D015233:Models, Statistical; D009010:Monte Carlo Method; D018579:Patient Selection; D016016:Proportional Hazards Models; D012307:Risk Factors; D013997:Time Factors; D009927:Tissue and Organ Procurement / Q000458:organization & administration / Q000706:statistics & numerical data*; D014481:United States / Q000453:epidemiology; D014850:Waiting Lists
correlated follow-up windows; dependent censoring; lung allocation score; multiple imputation; pseudo-observations