Fine Needle Aspiration Cytology of Diffuse-Type Tenosynovial Giant Cell Tumors.
BACKGROUND
Tenosynovial giant cell tumor (TSGCT), also known as giant cell tumor of tendon sheath or pigmented villonodular synovitis, is the most common benign tumor of the tendon and synovium. The intra-articular diffuse type can present as a large infiltrative mass involving adjacent soft tissue and sometimes causes secondary destruction of bone, which leads to radiographic and clinical concern for malignancy. The tumor may also be purely extra-articular.


METHODS
Here, we report the fine needle aspiration cytology findings of 2 cases of diffuse-type TSGCT with large mononuclear cells with eccentric nuclei, finely granular cytoplasm, and a peripheral well-defined cytoplasmic rim of hemosiderin ("ladybird cells").


CONCLUSIONS
Although the presence of ladybird cells has been described in tissue sections of TSGCT, their identification in cytological specimens has not been reported to our knowledge. When observed, their presence may aid in differentiating TSGCT from other lesions with multinucleated osteoclast-type giant cells occurring at or near joints.
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Zimin
Z
Zhao
Cherie
C
Paquette
Akeesha A
AA
Shah
Kristen A
KA
Atkins
Henry F
HF
Frierson
D000368:Aged; D001399:Azure Stains; D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle; D002467:Cell Nucleus / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D000070779:Giant Cell Tumor of Tendon Sheath / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D015726:Giant Cells / Q000737:chemistry / Q000473:pathology*; D006485:Hemosiderin / Q000032:analysis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008751:Methylene Blue; D065006:Papanicolaou Test; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed; D014966:Xanthenes
D001399:Azure Stains; D014408:Biomarkers, Tumor; C067461:Diff Quik; D014966:Xanthenes; D006485:Hemosiderin; D008751:Methylene Blue
Fine needle aspiration cytology; Ladybird cells; Multinucleated giant cells; Pigmented villonodular synovitis; Tenosynovial giant cell tumor