Palladium-Catalyzed Oxidative Annulation of ortho-Alkenylanilines and Allenes: An Access to Benzo[b]azepines.
Palladium-catalyzed oxidative annulation of ortho-alkenylanilines and allenes to constitute valuable, but synthetically challenging, benzo[b]azepines has been developed. The procedure, involving the cleavage of the terminal C(sp2)-H bond of the vinyl moiety and the participation of allenes as two-carbon cycloaddition partner, is attractive in terms of assembly efficiency and environmental friendliness. The transformation features mild reaction conditions and good functional group tolerance, resulting in a variety of benzo[b]azepines in good to excellent yields.
College of Chemistry and Materials Science, Northwest University , 1 Xuefu Road, Xi'an Shaanxi, P. R. China 710127.
Lisha
L
Wu
College of Chemistry and Materials Science, Northwest University , 1 Xuefu Road, Xi'an Shaanxi, P. R. China 710127.
Yinfeng
Y
Meng
Department of Chemistry, Emory & Henry College , Emory, Virginia 24327, United States.
Jamie
J
Ferguson
College of Chemistry and Materials Science, Northwest University , 1 Xuefu Road, Xi'an Shaanxi, P. R. China 710127.
Lijie
L
Wang
College of Chemistry and Materials Science, Northwest University , 1 Xuefu Road, Xi'an Shaanxi, P. R. China 710127.
Fanlong
0000-0002-4293-5133
F
Zeng