Long non-coding RNA LOC100129148 functions as an oncogene in human nasopharyngeal carcinoma by targeting miR-539-5p.
Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical roles in carcinogenesis and progression, including human nasopharyngeal carcinoma (NPC). The correlation between lncRNAs expression and NPC development has not been well identified in the recent literature. Recently, high-through put analysis reveals that LOC100129148 is highly expressed in NPC. However, whether the aberrant expression of LOC100129148 in NPC is corrected with tumorigenesis or prognosis has not been investigated. Herein, we identified that LOC100129148 was up-regulated in NPC tissues and cell lines, and higher expression of LOC100129148 resulted in a markedly poorer survival time. Over-expressed LOC100129148 favored, but silenced LOC100129148 hampered cell proliferation in NPC cells. Additionally, LOC100129148 enhanced the KLF12 expression through functioning as a competitive 'sponge' for miR-539-5p. Thus, our study reports a novel mechanism underlying NPC carcinogenesis, and provides a potential novel diagnosis and treatment biomarker for NPC.
Department of Otorhinolaryngology-Head and Neck Surgery, ZhongNan Hospital, Wuhan University, Wuhan 430071, Hubei, P. R. China.
Kai-Yu
KY
Sun
Department of Otorhinolaryngology-Head and Neck Surgery, ZhongNan Hospital, Wuhan University, Wuhan 430071, Hubei, P. R. China.
Tao
T
Peng
Department of Otorhinolaryngology-Head and Neck Surgery, ZhongNan Hospital, Wuhan University, Wuhan 430071, Hubei, P. R. China.
Zhe
Z
Chen
Department of Otorhinolaryngology-Head and Neck Surgery, ZhongNan Hospital, Wuhan University, Wuhan 430071, Hubei, P. R. China.
Peng
P
Song
Department of Otorhinolaryngology-Head and Neck Surgery, ZhongNan Hospital, Wuhan University, Wuhan 430071, Hubei, P. R. China.
Xu-Hong
XH
Zhou
D063646:Carcinogenesis / Q000235:genetics; D002277:Carcinoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D049109:Cell Proliferation / Q000235:genetics; D018450:Disease Progression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D053208:Kaplan-Meier Estimate; D051741:Kruppel-Like Transcription Factors / Q000096:biosynthesis; D035683:MicroRNAs / Q000235:genetics*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D009857:Oncogenes / Q000235:genetics*; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D015854:Up-Regulation
C436492:KLF12 protein, human; D051741:Kruppel-Like Transcription Factors; C552081:MIRN539 microRNA, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding
KLF12; LOC100129148; hsa-miRNA-539-5p (miR-539-5p); nasopharyngeal carcinoma (NPC); tumorigenesis