IsoSel: Protein Isoform Selector for phylogenetic reconstructions.
The reliability of molecular phylogenies is strongly dependent on the quality of the assembled datasets. In the case of eukaryotes, the selection of only one protein isoform per genomic locus is mandatory to avoid biases linked to redundancy. Here, we present IsoSel, a tool devoted to the selection of alternative isoforms in the context of phylogenetic reconstruction. It provides a better alternative to the widely used approach consisting in the selection of the longest isoforms and it performs better than Guidance, its only available counterpart. IsoSel is publicly available at http://doua.prabi.fr/software/isosel.
Univ. Lyon, Université Claude Bernard Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive, UMR 5558, F-69622, Villeurbanne, France.
Héloïse
H
Philippon
Univ. Lyon, Université Claude Bernard Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive, UMR 5558, F-69622, Villeurbanne, France.
Alexia
A
Souvane
Univ. Lyon, Université Claude Bernard Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive, UMR 5558, F-69622, Villeurbanne, France.
Céline
C
Brochier-Armanet
Univ. Lyon, Université Claude Bernard Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive, UMR 5558, F-69622, Villeurbanne, France.
Guy
http://orcid.org/0000-0002-6850-6265
G
Perrière
D000465:Algorithms; D017398:Alternative Splicing / Q000235:genetics; D000595:Amino Acid Sequence / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D006801:Humans; D010802:Phylogeny; D010944:Plants / Q000235:genetics; D020033:Protein Isoforms / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software
D020033:Protein Isoforms