New flavonol glycoside from Scabiosa prolifera L. aerial parts with in vitro antioxidant and cytotoxic activities.
Phytochemical investigation of the chemical constituents of the aerial parts of Scabiosa prolifera L. led to the isolation of one new flavonol glycoside, kaempferol-3-O-(4″,6″-di-E-p-coumaroyl)-β-D-galactopyranoside (1), along with ten other known compounds including luteolin-7-O-(2″-O-ethyl-β-glucopyranoside), β-sitosterol, β-sitosterylglucoside, ursolic acid, corosolic acid, ursolic acid 3-O-β-D-arabinopyranoside, apigenin, methyl-α-D-glucopyranoside, luteolin-7-O-β-glucopyranoside and isoorientin. The structures of all isolated compounds were established using chemical methods and spectroscopic methods including IR, UV, NMR (1D and 2D) and HRESIMS. All compounds were isolated for the first time from the plant. The antioxidant and cytotoxic activities of compounds 1 and 2 were also investigated.
a Faculty of Science, Department of Chemistry , Yarmouk University , Irbid , Jordan.
Mahmoud A
MA
Al-Qudah
a Faculty of Science, Department of Chemistry , Yarmouk University , Irbid , Jordan.
Noor K
NK
Otoom
b Faculty of Engineering Technology, Department of Physics and Basic Sciences , Al- Balqa' Applied University , Amman , Jordan.
Hala I
HI
Al-Jaber
c Department of Clinical Laboratory Sciences , College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, and King Abdullah International Medical Research Center (KAIMRC) , Jeddah , Kingdom of Saudi Arabia.
Ayman M
AM
Saleh
d School of Science, Department of Chemistry , The University of Jordan , Amman , Jordan.
Musa H
MH
Abu Zarga
e School of Pharmacy, Department of Pharmaceutical Sciences , The University of Jordan , Amman , Jordan.
Fatma U
FU
Afifi
d School of Science, Department of Chemistry , The University of Jordan , Amman , Jordan.
Sultan T
ST
Abu Orabi
D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D002301:Cardiac Glycosides; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification; D049917:Dipsacaceae / Q000737:chemistry*; D044948:Flavonols / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D044949:Kaempferols; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D012855:Sitosterols; D014315:Triterpenes
D000975:Antioxidants; D002301:Cardiac Glycosides; D003603:Cytotoxins; D044948:Flavonols; D006027:Glycosides; D044949:Kaempferols; D010936:Plant Extracts; D012855:Sitosterols; D014315:Triterpenes; C025473:gamma-sitosterol; C006552:kaempferol; C113861:corosolic acid
Dipsacaceae; Scabiosa prolifera; antioxidant activity; cytotoxic activity; kaempferol-3-O-(4″,6″-di-E-p-coumaroyl)-β-D-galactopyranoside