Finger tapping impairments are highly sensitive for evaluating upper motor neuron lesions.
BACKGROUND
Identifying highly sensitive and reliable neurological exam components are crucial in recognizing clinical deficiencies. This study aimed to investigate finger tapping performance differences between patients with CNS demyelinating lesions and healthy control subjects.


METHODS
Twenty-three patients with multiple sclerosis or clinically isolated syndrome with infratentorial and/or cervical cord lesions on MRI, and 12 healthy controls were videotaped while tapping the tip of the index finger against the tip and distal crease of the thumb using both the dominant and non-dominant hand. Videos were assessed independently by 10 evaluators (three MS neurologists, four neurology residents, three advanced practice providers). Sensitivity and inter-evaluator reliability of finger tapping interpretations were calculated.


RESULTS
A total of 1400 evaluations (four videos per each of the 35 subjects evaluated by 10 independent providers) were obtained. Impairments in finger tapping against the distal thumb crease of the non-dominant hand, identified by neurologists, had the greatest sensitivity (84%, p < 0.001) for detecting impairment. Finger tapping against the thumb crease was more sensitive than the thumb tip across all categories of providers. The best inter-evaluator reliability was associated with neurologists' evaluations for the thumb crease of the non-dominant hand (kappa = 0.83, p < 0.001).


CONCLUSIONS
Impaired finger tapping against the distal thumb crease of the non-dominant hand was a more sensitive technique for detecting impairments related to CNS demyelinating lesions. Our findings highlight the importance of precise examinations of the non-dominant side where impaired fine motor control secondary to an upper motor injury might be detectable earlier than the dominant side.
Department of Neurology and Neurotherapeutics, Clinical Center for Multiple Sclerosis, Multiple Sclerosis & Neuroimmunology Imaging Program, Neuroinnovation Program, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Afsaneh
A
Shirani
Department of Neurology and Neurotherapeutics, Clinical Center for Multiple Sclerosis, Multiple Sclerosis & Neuroimmunology Imaging Program, Neuroinnovation Program, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Braeden D
BD
Newton
Department of Neurology and Neurotherapeutics, Clinical Center for Multiple Sclerosis, Multiple Sclerosis & Neuroimmunology Imaging Program, Neuroinnovation Program, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Darin.Okuda@UTSouthwestern.edu.
Darin T
DT
Okuda
D000328:Adult; D003711:Demyelinating Diseases / Q000175:diagnosis*; D005260:Female; D005385:Fingers / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology*; D009103:Multiple Sclerosis / Q000175:diagnosis*; D009460:Neurologic Examination / Q000379:methods*; D015203:Reproducibility of Results
Demyelinating; Finger tapping; Magnetic resonance imaging; Multiple sclerosis; Neurological examination; Upper motor neuron