Croconaine nanoparticles with enhanced tumor accumulation for multimodality cancer theranostics.
A novel nanoparticle self-assembled by polyethylene glycol (PEG) modified croconaine dye (CR780) is presented for photoacoustic (PA)/near-infrared (NIR) fluorescence imaging-guided photothermal therapy (PTT). The simple PEGylation made CR780 amphiphilic, and led to their self-assembly into well-defined and uniform nanostructures with size tunable by controlling the assembly conditions. The CR780-PEG5K not only displayed the strength of small molecules (including rapid distribution to different organs, fast renal clearance and minimal accumulation to normal tissues), but also demonstrated the advantages of nanomaterials (including high physiological stability, multimodal theranostic ability, high tumor accumulation and retention). These facilely synthesized molecular nanoprobes showed great clinical translation potential as a versatile theranostic agent.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China.
Longguang
L
Tang
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, United States.
Fuwu
F
Zhang
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China.
Fei
F
Yu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China.
Wenjing
W
Sun
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China.
Menglin
M
Song
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, United States.
Xiaoyuan
X
Chen
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China. Electronic address: zhangxzh@xmu.edu.cn.
Xianzhong
X
Zhang
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China. Electronic address: xiaolian-sun@xmu.edu.cn.
Xiaolian
X
Sun
D000818:Animals; D016923:Cell Death; D004396:Coloring Agents / Q000737:chemistry; D003131:Combined Modality Therapy; D004705:Endocytosis; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D008819:Mice, Nude; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D061088:Photoacoustic Techniques; D011092:Polyethylene Glycols / Q000737:chemistry*; D013347:Subcellular Fractions / Q000378:metabolism; D013696:Temperature; D000068936:Theranostic Nanomedicine; D013876:Thiophenes / Q000737:chemistry*
C000625645:CR780-PEG5K; D004396:Coloring Agents; D013876:Thiophenes; D011092:Polyethylene Glycols
Controlled assembly; EPR effect; Molecular nanoprobe; Multimodality imaging; Photothermal therapy