Axial MR diffusion tensor imaging and tractography in clinical diagnosed and pathology confirmed cervical spinal cord astrocytoma.
OBJECTIVE
To evaluate the diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) features of cervical spinal cord astrocytoma.


METHODS
Eleven patients with cervical spinal cord astrocytomas and 10 healthy volunteers were recruited in this study. Conventional magnetic resonance imaging (MRI) and axial DTI were performed on a 3.0T MRI system. Apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) values for the lesions were measured. DTT was performed using the principal diffusion direction method.


RESULTS
ADC values of the lesions and the normal-appearing tissue around the tumour (NATAT) on T2-weighted imaging (T2WI) increased. The ADC values of the lesions were higher. The FA values of the lesions and the NATAT decreased significantly, with the lesions having lower FA values. The RD value (1.36±0.49) of the tumours was significantly higher than those found in the healthy controls, but similar for the AD value (1.84±0.56). There were no differences in ADC or FA values between lesions and NATAT in McCormick Type I vs. Type II patients. Based on the DTT, 7 patients with solid mass tumours were classified as Type I. One patient with a solid mass, 2 patients with cystic degeneration inside the lesions, and 1 patient with a cyst around the mass were classified as Type II.


CONCLUSIONS
FA values of the cervical spinal cord astrocytoma decreased, but the ADC values increased. DTI was sensitive for the evaluation of pathological changes that could not be visualized on T2WI. Our preliminary study indicates that DTT can be used to guide operation planning, and that axial images of DTT may be more valuable.
Department of Neurology, Yuquan Hospital, Clinical Neuroscience Institute, Medical Center, Tsinghua University, Beijing 100040, PR China.
Mangsuo
M
Zhao
Department of Neurology, Yuquan Hospital, Clinical Neuroscience Institute, Medical Center, Tsinghua University, Beijing 100040, PR China.
Bingxin
B
Shi
Department of Neurosurgery, Yuquan Hospital, Clinical Neuroscience Institute, Medical Center, Tsinghua University, Beijing 100040, PR China.
Tuoyu
T
Chen
Department of Neurosurgery, Yuquan Hospital, Clinical Neuroscience Institute, Medical Center, Tsinghua University, Beijing 100040, PR China.
Yuqi
Y
Zhang
Department of Neurology, Yuquan Hospital, Clinical Neuroscience Institute, Medical Center, Tsinghua University, Beijing 100040, PR China.
Tongchao
T
Geng
Department of Neurology, Yuquan Hospital, Clinical Neuroscience Institute, Medical Center, Tsinghua University, Beijing 100040, PR China.
Liyan
L
Qiao
Department of Neurology, PLA General Hospital, Beijing 100853, PR China.
Mingjie
M
Zhang
Center for Biomedical Imaging Research, Tsinghua University, Beijing 100084, PR China.
Le
L
He
Department of Neurosurgery, Yuquan Hospital, Clinical Neuroscience Institute, Medical Center, Tsinghua University, Beijing 100040, PR China. Electronic address: zuohuancong@163.com.
Huancong
H
Zuo
Department of Neurosurgery, Changgung Hospital, Medical Center, Tsinghua University, Beijing 102218, PR China. Electronic address: youngneurosurgeon@163.com.
Guihuai
G
Wang
D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000000981:diagnostic imaging* / Q000473:pathology*; D002574:Cervical Vertebrae / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D013120:Spinal Cord Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D055815:Young Adult
Astrocytoma; Cervical spinal cord; Diffusion tensor imaging; Diffusion tensor tractography