Preparation and evaluation of molecularly imprinted polymer for selective recognition and adsorption of gossypol.
Molecularly imprinted polymers (MIPs) were designed and prepared via bulk thermal polymerization with gossypol as the template molecule and dimethylaminoethyl methacrylate as the functional monomer. The morphology and microstructures of MIPs were characterized by scanning electron microscope and Brunauer-Emmett-Teller surface areas. Static adsorption tests were performed to evaluate adsorption behavior of gossypol by the MIPs. It was found that adsorption kinetics and adsorption isotherms data of MIPs for gossypol were fit well with the pseudo-second-order model and Freundlich model, respectively. Scatchard analysis showed that heterogeneous binding sites were formed in the MIPs, including lower-affinity binding sites with the maximum adsorption of 252 mg/g and higher-affinity binding sites with the maximum adsorption of 632 mg/g. Binding studies also revealed that MIPs had favorable selectivity towards gossypol compared with non-imprinted polymers. Furthermore, adsorption capacity of MIPs maintained above 90% after 5 regeneration cycles, indicating MIPs were recyclable and could be used multiple times. These results demonstrated that prepared MIPs could be a promising functional material for selective adsorption of gossypol.
Center for Green Chemistry and Organic Functional Materials Laboratory, Xinjiang Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Urumqi, China.|University of the Chinese Academy of Sciences, Beijing, China.
Keke
K
Zhi
Center for Green Chemistry and Organic Functional Materials Laboratory, Xinjiang Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Urumqi, China.|University of the Chinese Academy of Sciences, Beijing, China.
Lulu
L
Wang
Center for Green Chemistry and Organic Functional Materials Laboratory, Xinjiang Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Urumqi, China.|University of the Chinese Academy of Sciences, Beijing, China.|Department of Chemical and Environmental Engineering, Xinjiang Institute of Engineering, Urumqi, China.
Yagang
0000-0001-9457-1450
Y
Zhang
Center for Green Chemistry and Organic Functional Materials Laboratory, Xinjiang Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Urumqi, China.|University of the Chinese Academy of Sciences, Beijing, China.
Xuemin
X
Zhang
Center for Green Chemistry and Organic Functional Materials Laboratory, Xinjiang Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Urumqi, China.
Letao
L
Zhang
Center for Green Chemistry and Organic Functional Materials Laboratory, Xinjiang Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Urumqi, China.
Li
L
Liu
College of Pharmacy, Xinjiang Medical University, Urumqi, China.
Jun
J
Yao
College of Pharmacy, Xinjiang Medical University, Urumqi, China.
Wei
W
Xiang
D000327:Adsorption; D001665:Binding Sites; D006072:Gossypol / Q000737:chemistry / Q000302:isolation & purification*; D008689:Methacrylates / Q000737:chemistry*; D054802:Molecular Imprinting; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D052616:Solid Phase Extraction; D017550:Spectroscopy, Fourier Transform Infrared
D008689:Methacrylates; D011108:Polymers; D006072:Gossypol
gossypol; molecular recognition; molecularly imprinted polymer; selective adsorption