Interleukin-6 expression in disc derangement of human temporomandibular joint and association with osteoarthrosis.
The inflammatory process is a coordinated response that protects host after infection or trauma, involving several molecular reactions. Once the inflammation is closely linked to the process of destruction of the temporomandibular joint, this study aims to examine, by immunohistochemistry, the expression of interleukin-6 (IL-6), an important inflammatory marker, in temporomandibular articular discs of patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR) and its association with osteoarthrosis (OA). Thirty-eight (n = 38) articular discs were divided into two cutoffs: 1) analysis 1: 4 control (acute pathology), 17 ADDwR, 17 ADDwoR; and 2) analysis 2: without OA (n = 21) and with OA (n = 17). The area of immunostaining was compared statistically between groups (p < 0.05). In the disc samples, no significant differences were observed between the groups ADDwR and ADDwoR, and with and without OA, in respect to the expression of IL-6 by immunohistochemical examination. Future studies should be conducted with a larger sample size, which could clarify the association of the inflammatory mediator IL-6 with temporomandibular joint dysfunction.
School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Flavio
F
de Alcântara Camejo
School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Marina
M
Azevedo
School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Viviane
V
Ambros
School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Karina São Thiago
KST
Caporal
School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Andrea Duarte
AD
Doetzer
School of Dentistry, Marquette University, Milwalkee, USA.
Luis Eduardo
LE
Almeida
School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Marcia
M
Olandoski
School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Lucia
L
Noronha
School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil. Electronic address: paula.trevilatto@pucpr.br.
Paula Cristina
PC
Trevilatto
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D019224:Temporomandibular Joint Disc / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D013705:Temporomandibular Joint Disorders / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D055815:Young Adult
D015850:Interleukin-6
IL-6; Osteoarthrosis; Temporomandibular derangement; Temporomandibular disc