Pharmacokinetic Profiles of Meloxicam and Sustained-release Buprenorphine in Prairie Dogs (Cynomys ludovicianus).
In this study, we evaluated the pharmacokinetic profiles of meloxicam and sustained-release (SR) buprenorphine in prairie dogs. The 4 treatment groups were: low-dose meloxicam (0.2 mg/kg SC), high-dose meloxicam (4 mg/kg SC), low-dose buprenorphine SR (0.9 mg/kg SC), and high-dose buprenorphine SR (1.2 mg/kg SC). The highest plasma concentrations occurred within 4 h of administration for both meloxicam treatment groups. The therapeutic range of meloxicam in prairie dogs is currently unknown. However, as compared with the therapeutic range documented in other species (0.39 - 0.91 μg/mL), the mean plasma concentration of meloxicam fell below the minimal therapeutic range prior to 24 h in the low-dose group but remained above therapeutic levels for more than 72 h in the high-dose group. These findings suggest that the current meloxicam dosing guidelines may be subtherapeutic for prairie dogs. The highest mean plasma concentration for buprenorphine SR occurred at the 24-h time point (0.0098 μg/mL) in the low-dose group and at the 8-h time point (0.015 μg/mL) for the high-dose group. Both dosages of buprenorphine SR maintained likely plasma therapeutic levels (0.001 μg/mL, based on previous rodent studies) beyond 72 h. Given the small scale of the study and sample size, statistical analysis was not performed. The only adverse reactions in this study were mild erythematous reactions at injection sites for buprenorphine SR.
Comparative Medicine Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;, Email: yjn5@cdc.gov.
Cynthia D
CD
Cary
Comparative Medicine Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Nicole L
NL
Lukovsky-Akhsanov
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Nadia F
NF
Gallardo-Romero
Comparative Medicine Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Cassandram M
CM
Tansey
Comparative Medicine Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Sharon D
SD
Ostergaard
Comparative Medicine Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Willie D
WD
Taylor
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Clint N
CN
Morgan
Comparative Medicine Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Nathaniel
N
Powell
Comparative Medicine Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
George W
GW
Lathrop
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Christina L
CL
Hutson
D000701:Analgesics, Opioid / Q000493:pharmacokinetics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics; D002047:Buprenorphine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics; D000077239:Meloxicam; D012589:Sciuridae / Q000097:blood*; D013843:Thiazines / Q000493:pharmacokinetics*; D013844:Thiazoles / Q000493:pharmacokinetics*
D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D013843:Thiazines; D013844:Thiazoles; D002047:Buprenorphine; D000077239:Meloxicam