Significant Decrease in Pertactin-Deficient Bordetella pertussis Isolates, Japan.
Prevalence of pertactin-lacking Bordetella pertussis isolates has been observed worldwide. In Japan, however, we found that the frequency of pertactin-deficient isolates in 2014-2016 (8%) was significantly lower than the frequency in 2005-2007 (41%), 2008-2010 (35%), and 2011-2013 (25%). This reduction was closely associated with changes in genotypes.
Yukihiro
Y
Hiramatsu
Yusuke
Y
Miyaji
Nao
N
Otsuka
Yoshichika
Y
Arakawa
Keigo
K
Shibayama
Kazunari
K
Kamachi
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D001886:Bordetella pertussis / Q000235:genetics*; D019143:Evolution, Molecular; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D005838:Genotype; D007564:Japan; D009154:Mutation; D010566:Virulence Factors, Bordetella / Q000235:genetics / Q000378:metabolism*
D001425:Bacterial Outer Membrane Proteins; D010566:Virulence Factors, Bordetella; C068929:pertactin
Bordetella pertussis; Japan; bacteria; genotype; multilocus variable-number tandem-repeat analysis; pertactin; pertussis; respiratory infections; whooping cough