Modifications in dietary and alcohol intakes between before and after cancer diagnosis: Results from the prospective population-based NutriNet-Santé cohort.
Postdiagnosis diet and alcohol consumption may be associated with cancer prognosis, recurrence and mortality. Our aim was to investigate food, nutrient and alcohol intake variations between before and after cancer diagnosis and their determinants in a prospective cohort. Subjects (n = 696) were incident cancer cases diagnosed in the NutriNet-Santé cohort between 2009 and 2016. Food, nutrient and alcohol intakes were prospectively collected using repeated nonconsecutive 24-hr dietary records since subjects' inclusion (i.e. an average of 2 y before diagnosis). Mean number of dietary records per subject was 5.9 before and 8.1 after diagnosis. All dietary data before and after diagnosis were compared by mixed models. Factors associated with the main dietary changes observed were also investigated using multivariable logistic regressions. We observed a decrease in intakes of vegetables (mean decrease in intake in patients who decreased their intake=-102.4 ± 79.8 g/d), dairy products (-93.9 ± 82.8 g/d), meat/offal (-35.5 ± 27.8/d), soy products (-85.8 ± 104.1 g/d), sweetened soft drinks (-77.9 ± 95.4 g/d), and alcoholic drinks (-92.9 ± 119.9 g/d), and an increase in broths (42.1 ± 34.9 g/d) and fats/sauces (18.0 ± 13.4 g/d). We observed a decrease in energy intake (-377.2 ± 243.5 kcal/d) and in intakes of alcohol (-7.6 ± 9.4 g/d) proteins (-17.4 ± 12.5 g/d), and several vitamins (p < 0.05) and micronutrients (p < 0.05). Conversely, lipid (19.4 ± 14.6 g/d), SFA (9.3 ± 7.0 g/d), MUFA (8.3 ± 6.3 g/d) and vitamin E (3.9 ± 3.3 mg/d) intakes increased after diagnosis. This large prospective study suggests that cancer diagnosis is a key period for nutritional changes. It highlights some healthy behaviors such as a decrease in alcohol and sweetened drink consumption, but also less favorable trends, such as a decrease in vegetable consumption and in many vitamin and mineral intakes. These results provide insights to identify and target recommendations to put forward for better nutritional care of cancer survivors.
Sorbonne Paris Cité Epidemiology and Statistics Research Center, Nutritional Epidemiology Research Team (EREN): Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Bobigny, F-93017, France.
Philippine
0000-0001-8130-8485
P
Fassier
Sorbonne Paris Cité Epidemiology and Statistics Research Center, Nutritional Epidemiology Research Team (EREN): Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Bobigny, F-93017, France.|Oncology Department, Avicenne Hospital, Bobigny, F-93017, France.
Laurent
L
Zelek
Sorbonne Paris Cité Epidemiology and Statistics Research Center, Nutritional Epidemiology Research Team (EREN): Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Bobigny, F-93017, France.
Lucie
L
Lécuyer
Léon Bérard Cancer Center, Lyon, F-69008, France.
Patrick
P
Bachmann
Léon Bérard Cancer Center, Lyon, F-69008, France.|Cancer Research Centre of Lyon UMR Inserm 1052 CNRS 5286 CLB, Lyon, F-69003, France.
Marina
0000-0001-9900-5861
M
Touillaud
Sorbonne Paris Cité Epidemiology and Statistics Research Center, Nutritional Epidemiology Research Team (EREN): Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Bobigny, F-93017, France.
Nathalie
N
Druesne-Pecollo
Sorbonne Paris Cité Epidemiology and Statistics Research Center, Nutritional Epidemiology Research Team (EREN): Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Bobigny, F-93017, France.
Pilar
P
Galan
Sociology Department, University of Rouen, DySola, EA 4701, Rouen, F-76821, France.
Patrice
P
Cohen
Sociology Department, University of Rouen, DySola, EA 4701, Rouen, F-76821, France.
Hélène
H
Hoarau
Sorbonne Paris Cité Epidemiology and Statistics Research Center, Nutritional Epidemiology Research Team (EREN): Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Bobigny, F-93017, France.
Paule
P
Latino-Martel
Sorbonne Paris Cité Epidemiology and Statistics Research Center, Nutritional Epidemiology Research Team (EREN): Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Bobigny, F-93017, France.
Emmanuelle
E
Kesse-Guyot
Sorbonne Paris Cité Epidemiology and Statistics Research Center, Nutritional Epidemiology Research Team (EREN): Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Bobigny, F-93017, France.
Julia
J
Baudry
Sorbonne Paris Cité Epidemiology and Statistics Research Center, Nutritional Epidemiology Research Team (EREN): Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Bobigny, F-93017, France.|Public Health Department, Avicenne Hospital, Bobigny, F-93017, France.
Serge
S
Hercberg
Sorbonne Paris Cité Epidemiology and Statistics Research Center, Nutritional Epidemiology Research Team (EREN): Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Bobigny, F-93017, France.
Mélanie
M
Deschasaux
Sorbonne Paris Cité Epidemiology and Statistics Research Center, Nutritional Epidemiology Research Team (EREN): Inserm U1153, Inra U1125, Cnam, Paris 5, 7 and 13 Universities, Bobigny, F-93017, France.
Mathilde
M
Touvier
D000428:Alcohol Drinking; D004032:Diet; D004041:Dietary Fats; D002149:Energy Intake; D005260:Female; D005500:Follow-Up Studies; D005518:Food Preferences; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis* / Q000517:prevention & control*; D011379:Prognosis; D011446:Prospective Studies; D014675:Vegetables
D004041:Dietary Fats
Diet; alcohol intake; cancer survivors; nutrient intake; prospective cohort