Relationship Between Ktransand K1with SimultaneousVersusSeparate MR/PET in Rabbits with VX2 Tumors.
To compare the relationship between Ktransfrom DCE-MRI and K1from dynamic13N-NH3-PET, with simultaneous and separate MR/PET in the VX-2 rabbit carcinoma model.



MR/PET was performed simultaneously and separately, 14 and 15 days after VX-2 tumor implantation at the paravertebral muscle. The Ktransand K1values were estimated using an in-house software program. The relationships between Ktransand K1were analyzed using Pearson's correlation coefficients and linear/non-linear regression function.



Assuming a linear relationship, Ktransand K1exhibited a moderate positive correlations with both simultaneous (r=0.54-0.57) and separate (r=0.53-0.69) imaging. However, while the Ktransand K1from separate imaging were linearly correlated, those from simultaneous imaging exhibited a non-linear relationship. The amount of change in K1associated with a unit increase in Ktransvaried depending on Ktransvalues.



The relationship between Ktransand K1may be mis-interpreted with separate MR and PET acquisition.
Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.|Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Kyung Hee
KH
Lee
Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.|Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Seung Kwan
SK
Kang
Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea jmgoo@plaza.snu.ac.kr jaes@snu.ac.kr.|Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.|Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jin Mo
JM
Goo
Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea jmgoo@plaza.snu.ac.kr jaes@snu.ac.kr.|Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jae Sung
JS
Lee
Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.|Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Gi Jeong
GJ
Cheon
Department of Neuroscience, College of Medicine, Gachon University, Incheon, Republic of Korea.
Seongho
S
Seo
Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.|Armed Forces Seoul Hospital, Seoul, Republic of Korea.
Eui Jin
EJ
Hwang
D000818:Animals; D002277:Carcinoma / Q000378:metabolism; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D064847:Multimodal Imaging / Q000379:methods; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000473:pathology*; D010477:Perfusion; D049268:Positron-Emission Tomography; D011817:Rabbits
D003287:Contrast Media
13N-NH3 PET; MR/PET; dynamic contrast enhanced-MRI; perfusion parameter; rabbit