Development of anticancer agents targeting the Hedgehog signaling.
Hedgehog signaling is an evolutionarily conserved pathway which is essential in embryonic and postnatal development as well as adult organ homeostasis. Abnormal regulation of Hedgehog signaling is implicated in many diseases including cancer. Consequently, substantial efforts have made in the past to develop potential therapeutic agents that specifically target the Hedgehog signaling for cancer treatment. Here, we review the therapeutic agents for inhibition of the Hedgehog signaling and their clinical advances in cancer treatment.
College of Life Science, Yan'an University, Yan'an, 716000, Shaanxi, China.
Xiangqian
X
Zhang
College of Life Science, Yan'an University, Yan'an, 716000, Shaanxi, China.
Ye
Y
Tian
Medical College, Yan'an University, Yan'an, 716000, Shaanxi, China.
Yanling
Y
Yang
College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, 91766, USA. jhao@westernu.edu.|Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, 91766, USA. jhao@westernu.edu.
Jijun
J
Hao
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D055808:Drug Discovery; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects*; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D053823:Hedgehog Proteins; D054852:Small Molecule Libraries
Cancer; Drugs; Hedgehog signaling; Patched; Safety and clinic; Small molecules; Smothern; Therapeutic