The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.
BACKGROUND
There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.


OBJECTIVE
This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).


METHODS
In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.


RESULTS
Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects.


CONCLUSIONS
Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied.


CONCLUSIONS
The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.
Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
Indermeet
I
Kohli
Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.
Rubina
R
Shafi
Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
Prescilia
P
Isedeh
Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
James L
JL
Griffith
Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
Mohammed S
MS
Al-Jamal
Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
Narumol
N
Silpa-Archa
Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.
Bradford
B
Jackson
Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.
Mohammed
M
Athar
Independent Researcher, Boston, Massachusetts.
Nikiforos
N
Kollias
Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.
Craig A
CA
Elmets
Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
Henry W
HW
Lim
Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address: ihamzav1@hfhs.org.
Iltefat H
IH
Hamzavi
D000284:Administration, Oral; D005260:Female; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D032494:Polypodium; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects*; D014466:Ultraviolet Rays
D010936:Plant Extracts
Polypodium leucotomos extract; colorimetry; cyclobutane pyrimidine dimers; excimer laser; minimal erythema dose; sunburn cells; ultraviolet