Lipid metabolism and lung cancer.
Lung cancer is currently one of the most serious health issues in developed and developing countries. There are multiple available treatment options; however survival still remains very poor. Despite metabolism alteration being one of the hallmarks described in human cancer, lipid metabolism disorders are less known. They are recently becoming more important in this setting and therefore achieving a deeper knowledge might be helpful to obtain new strategies to accurate diagnosis, estimate prognosis, and develop therapeutic agents based on bioactive compounds such as cerulenin, SCD1, ACLY inhibitors, statins, polyphenolic compounds, etc. The present paper reviews the basis of lipid metabolism in lung cancer and suggests potential biomarkers. Further investigation is crucial to improve our knowledge in this area.
Medical Oncology Department, Infanta Sofía University Hospital, San Sebastián de los Reyes, Madrid, Spain. Electronic address: mariamesal@gmail.com.
María
M
Merino Salvador
Madrid Institute for Advanced Studies on Food (IMDEA-Food), Madrid, Spain.
Marta
M
Gómez de Cedrón
Madrid Institute for Advanced Studies on Food (IMDEA-Food), Madrid, Spain; Precision Oncology Laboratory (POL), Infanta Sofía University Hospital, San Sebastián de los Reyes, Madrid, Spain.
Juan
J
Moreno Rubio
Medical Oncology Department, Infanta Sofía University Hospital, San Sebastián de los Reyes, Madrid, Spain.
Sandra
S
Falagán Martínez
Madrid Institute for Advanced Studies on Food (IMDEA-Food), Madrid, Spain.
Ruth
R
Sánchez Martínez
Medical Oncology Department, Infanta Sofía University Hospital, San Sebastián de los Reyes, Madrid, Spain.
Enrique
E
Casado
Madrid Institute for Advanced Studies on Food (IMDEA-Food), Madrid, Spain.
Ana
A
Ramírez de Molina
Medical Oncology Department, Infanta Sofía University Hospital, San Sebastián de los Reyes, Madrid, Spain.
María
M
Sereno
D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008175:Lung Neoplasms / Q000378:metabolism*
Bioactive compounds; Biomarker; Lipid metabolism; Lung cancer