Deletion of GSTM1 and GSTT1 genes and lung cancer survival: a systematic review.
OBJECTIVE
The mechanisms of lung carcinogenesis are not fully understood. Not all smokers develop lung cancer, indicating that genetic variations and other environmental factors may play an important role in its development. The human glutathione S-transferases (GSTs) have been associated with an increased risk of lung cancer. Glutathione S-transferases are phase II biotransformation enzymes that play a role in detoxifying a wide range of exogenous agents including carcinogens but also anticarcinogenic drugs.


METHODS
We assessed the effect of allelic deletions in the GSTM1 and GSTT1 genotypes on lung cancer overall survival through a systematic review of the scientific literature after applying predefined inclusion and exclusion criteria.


RESULTS
Most of the included studies found no effect or a tendency to worse survival for individuals with deletion of GSTs.


CONCLUSIONS
Further studies are necessary to understand the magnitude of the effect of the deletion of both genes on lung cancer survival.
Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, La Coruña - Spain.|Pulmonary Department, Hospital Álvaro Cunqueiro, EOXI Vigo, NeumoVigoI+I Research Group, Vigo Biomedical Research Institute (IBIV), Vigo - Spain.
Cristina
C
Ramos Hernández
Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, La Coruña - Spain.|Pulmonary Department, Hospital Álvaro Cunqueiro, EOXI Vigo, NeumoVigoI+I Research Group, Vigo Biomedical Research Institute (IBIV), Vigo - Spain.
Cecilia
C
Mouronte-Roibás
Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, La Coruña - Spain.|CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid - Spain.|Service of Preventive Medicine, University Hospital, Complex of Santiago de Compostela, Santiago de Compostela, La Coruña - Spain.
Juan Miguel
JM
Barros-Dios
Pulmonary Department, Hospital Álvaro Cunqueiro, EOXI Vigo, NeumoVigoI+I Research Group, Vigo Biomedical Research Institute (IBIV), Vigo - Spain.
Alberto
A
Fernández-Villar
Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, La Coruña - Spain.|CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid - Spain.
Alberto
A
Ruano-Ravina
D063646:Carcinogenesis / Q000235:genetics*; D018572:Disease-Free Survival; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D012307:Risk Factors
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1