Clinical and microbiological efficacy of 4% Garcinia mangostana L. pericarp gel as local drug delivery in the treatment of chronic periodontitis: A randomized, controlled clinical trial.
OBJECTIVE
The aim of the present study was to assess the periodontal status of individuals and the presence of red complex microorganisms (RCM), such as Treponema denticola (Td), Porphyromonas gingivalis, and Tannerella forsythia in the subgingival tissues of periodontitis patients before and after the application of 4% mangostana gel (Garcinia mangostana [MGA]) as an adjunct to scaling and root planing (SRP).


METHODS
Twenty-five patients (MGA group) were treated with SRP, and the subgingival application of mangostana gel was used as local drug delivery. Twenty-five patients (placebo group) were treated with SRP and placebo gel. Clinical parameters were recorded, and the presence of RCM was assessed at baseline and at the third month.


RESULTS
Clinical parameters, such as probing pocket depth, clinical attachment level, bleeding index, plaque index, and Td, were significantly reduced in the MGA group compared to the placebo group from baseline to the third month.


CONCLUSIONS
There was a significant improvement in the periodontal status with a reduction in Td with the application of mangostana gel in periodontal pockets. In the near future, 4% mangostana gel can be used as an adjunct to SRP to provide a new dimension to periodontal therapy.
Department of Periodontology, Meenakshi Ammal Dental College, Meenakshi Academy of Higher Education and Research, Chennai, India.
Jaideep
J
Mahendra
Department of Periodontics, Annamalai University, Chidambaram, India.
Little
L
Mahendra
Department of Periodontology, Meenakshi Ammal Dental College, Meenakshi Academy of Higher Education and Research, Chennai, India.
Priyadharshini
P
Svedha
Department of Periodontology, Meenakshi Ammal Dental College, Meenakshi Academy of Higher Education and Research, Chennai, India.
Sandhya
S
Cherukuri
Department Of Periodontology, Stony Brook University, Stony Brook, New York, USA.
Georgios E
GE
Romanos
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D055113:Chronic Periodontitis / Q000188:drug therapy* / Q000382:microbiology*; D004311:Double-Blind Method; D005260:Female; D029762:Garcinia mangostana; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D016896:Treatment Outcome
D005782:Gels; D010936:Plant Extracts

Garcinia mangostana
; antimicrobial; local drug delivery; periodontitis; red complex microorganisms