Antigenic and immunogenic spectrum of foot-and-mouth disease vaccine strain O1Campos against representative viruses of topotypes that circulated in Asia over the past decade.
Identifying vaccine strains to control outbreaks of foot-and-mouth disease virus that could spread to new regions is essential for contingency plans. This is the first report on the antigenic/immunogenic relationships of the South American O1/Campos vaccine strain with representative isolates of the three currently active Asian type O topotypes. Virus neutralization tests using O1/Campos post-vaccination sera derived from cattle and pigs predicted for both species acceptable cross-protection, even after single vaccination, established by r1 values and by expectancy of protection using monovalent or polyvalent vaccines. The results indicate that effective oil vaccines containing the O1/Campos strain can be used against Asian isolates, expanding the scope of O1/Campos strain included in vaccine banks to control emergencies caused by Asian viruses, even on single-dose vaccination, and to cover the need of effective vaccines in Asia during systematic vaccination.
Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA), Talcahuano 1660, CP 1640 Martínez, Argentina.
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Galdo Novo
Centro de Virología Animal, Instituto de Ciencia y Tecnología Dr. César Milstein, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Saladillo 2468, CP 1440 Buenos Aires, Argentina. Electronic address: vmalirat@hotmail.com.
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Malirat
Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA), Talcahuano 1660, CP 1640 Martínez, Argentina.
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Maradei
Biogénesis Bagó S.A., Ruta Panamericana Km 38.2, CP 1619 Garín, Argentina.
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Espinoza
Biogénesis Bagó S.A., Ruta Panamericana Km 38.2, CP 1619 Garín, Argentina.
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Smitsaart
Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA), Talcahuano 1660, CP 1640 Martínez, Argentina.
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Pedemonte
Centro de Virología Animal, Instituto de Ciencia y Tecnología Dr. César Milstein, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Saladillo 2468, CP 1440 Buenos Aires, Argentina.
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Mattion
Centro de Virología Animal, Instituto de Ciencia y Tecnología Dr. César Milstein, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Saladillo 2468, CP 1440 Buenos Aires, Argentina. Electronic address: ingrid.bergmann@hotmail.com.
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Bergmann
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D056738:Cross Protection; D003429:Cross Reactions; D005536:Foot-and-Mouth Disease / Q000821:virology*; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology*; D051379:Mice; D009500:Neutralization Tests; D014765:Viral Vaccines / Q000276:immunology*
D000911:Antibodies, Monoclonal; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D000956:Antigens, Viral; D014765:Viral Vaccines
Foot-and-mouth disease; Vaccine matching