Genetic association between the cyclin-dependent kinase inhibitor gene p27/Kip1 polymorphism (rs34330) and cancer susceptibility: a meta-analysis.
The p27 rs34330 (-79C/T) polymorphism has been widely studied for human cancer susceptibility. The current findings, however, still remained controversial. Therefore, we performed the meta-analysis to provide a more accurate result. Eligible studies were identified from PubMed database up to June 2015. The association of p27 rs34330 polymorphism and cancer susceptibility was estimated with odds ratios and corresponding 95% confidence intervals. The meta-analysis was performed with Stata 12. A total of ten studies with 11,214 cases and more than 8,776 controls were included in the meta-analysis (including breast, lung, thyroid, endometrial, and hepatocellular cancer). In pooled analysis, p27 gene rs34330 polymorphism significantly increased the cancer susceptibility. Subgroup analysis indicated that the elevated risk was observed under all the genetic models for Asians and under three genetic models for Caucasians. Results of sensitivity analysis were similar to the overall results. The results suggested that the p27 rs34330 polymorphism increased the cancer susceptibility, especially in Asians. Further well-designed and large sample size studies are warranted to verify the conclusion.
Center for Evidence-Based Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan, 475000, China.
Xiao-Ke
XK
Cheng
Department of Emergency, Beijing Electric Power Hospital, Taipingxili Jia 1, Beijing, 100073, China.
Xue-Jun
XJ
Wang
Center for Evidence-Based Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan, 475000, China.|Department of Urology, Huaihe Hospital of Henan University, Kaifeng, Henan, 475000, China.
Xiao-Dong
XD
Li
Center for Evidence-Based Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan, 475000, China.|Department of Urology, Huaihe Hospital of Henan University, Kaifeng, Henan, 475000, China.|Department of General Surgery, Huaihe Hospital of Henan University, Kaifeng, Henan, 475000, China.
Xue-Qun
XQ
Ren
D000483:Alleles; D044466:Asian People / Q000235:genetics; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000235:genetics*; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
D050760:Cyclin-Dependent Kinase Inhibitor p27