Tetraploidy acute myeloid leukaemia after chromosome 16 inversion.
Our patient is a 36-year-old man referred by his general physician to the Department of Hematology because of mild neutropenia in a routine analysis at work. There was no history of previous diseases, and examination was normal. Blood investigations confirmed the neutropenia and showed elongation of prothrombin time. A bone marrow examination was performed revealing about 10% of myeloblasts on the aspirate smears. A cytogenetic study showed chromosome 16 inversion in all of these cells and tetraploidy only in some of them, which were extremely large in size. According to the revised WHO classification of tumours (2008), the patient was diagnosed as a case of acute myeloid leukaemia with chromosome 16 inversion.
Department of Hematology, Hospital Universitario de Mostoles, Mostoles, Madrid, Spain.
Alba Sara
http://orcid.org/0000-0002-4544-7848
AS
Vilches
Department of Genetics, Hospital Universitario de Mostoles, Mostoles, Madrid, Spain.
Aranzazu
A
Díaz de Bustamante
Department of Hematology, Hospital Universitario de Mostoles, Mostoles, Madrid, Spain.
Jorge
J
Sanchez-Calero
Department of Genetics, Hospital Universitario de Mostoles, Mostoles, Madrid, Spain.
María Teresa
MT
Darnaude
D000328:Adult; D002869:Chromosome Aberrations; D002885:Chromosomes, Human, Pair 16; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D008297:Male; D009503:Neutropenia / Q000209:etiology; D012074:Remission Induction; D057891:Tetraploidy