Domestic Pig Unlikely Reservoir for MERS-CoV.
We tested the suitability of the domestic pig as a model for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Inoculation did not cause disease, but a low level of virus replication, shedding, and seroconversion were observed. Pigs do not recapitulate human MERS-CoV and are unlikely to constitute a reservoir in nature.
Emmie
E
de Wit
Friederike
F
Feldmann
Eva
E
Horne
Cynthia
C
Martellaro
Elaine
E
Haddock
Trenton
T
Bushmaker
Kyle
K
Rosenke
Atsushi
A
Okumura
Rebecca
R
Rosenke
Greg
G
Saturday
Dana
D
Scott
Heinz
H
Feldmann
D000818:Animals; D018352:Coronavirus Infections / Q000662:veterinary* / Q000821:virology; D004197:Disease Reservoirs / Q000662:veterinary* / Q000821:virology; D058507:Host Specificity; D065207:Middle East Respiratory Syndrome Coronavirus / Q000502:physiology*; D013552:Swine; D013553:Swine Diseases / Q000821:virology*
DPP4; MERS-CoV; Middle East respiratory syndrome coronavirus; United States; animal models; dipeptidyl peptidase 4; domestic pig; pigs; viruses; zoonoses