Mitochondrial transplantation: From animal models to clinical use in humans.
Mitochondrial transplantation is a novel therapeutic intervention to treat ischemia/reperfusion related disorders. The method for mitochondrial transplantation is simple and rapid and can be delivered to the end organ either by direct injection or vascular infusion. In this review, we provide mechanistic and histological studies in large animal models and present data to show clinical efficacy in human patients.
Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: james_mccully@hms.harvard.edu.
James D
JD
McCully
Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Douglas B
DB
Cowan
Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Sitaram M
SM
Emani
Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Pedro J
PJ
Del Nido
D000818:Animals; D001688:Biological Products / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008928:Mitochondria / Q000502:physiology*; D015427:Reperfusion Injury / Q000628:therapy*; D014180:Transplantation / Q000379:methods*; D016896:Treatment Outcome
D001688:Biological Products
Cardiac; Ischemia; Mitochondria; Reperfusion