An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity.
Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology. Occlusal and panoramic radiographs showed no bone involvement. Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity. During this exam, a nodular image of low echogenicity measuring about 2.7 × 1.8 cm was detected. An excisional biopsy was performed and histopathological analysis revealed a well-defined tumor-like lesion with alternation between hypercellular areas without a defined pattern and hypocellular areas. On immunohistochemistry, the tumor was positive for CD34 and CD99 and negative forα-SMA, S-100, and bcl-2. Combining the histopathological and immunohistochemical features, the diagnosis was solitary fibrous tumor. The patient is under periodical clinical follow-up and shows no signs of recurrence 7 months after surgical excision of the tumor. The combination of clinical-pathological and immunohistochemical features is necessary for the diagnosis.
Oral Pathology Postgraduate Program, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Everton Freitas
0000-0002-2173-7672
EF
de Morais
Oral Pathology Postgraduate Program, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Deborah Gondim Lambert
DG
Moreira
Oral Pathology Postgraduate Program, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Viviane Alves De
VA
Oliveira
Division of Oral and Maxillofacial Surgery, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Rodrigo Rodrigues
RR
Rodrigues
Division of Oral and Maxillofacial Surgery, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Adriano Rocha
AR
Germano
Oral Pathology Postgraduate Program, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Roseana de Almeida
RA
Freitas