Role of skeletal muscle glucocorticoid receptor in systemic energy homeostasis.
Glucocorticoids (GCs) affect nearly every organ and tissue in the body, regulating diverse physiologic processes including energy homeostasis. The metabolic mission of GCs is to supply enough glucose into the circulation to fuel the brain and ensure survival of the organism under conditions of acute stress or starvation. Recent studies have revealed that GCs, via orchestration between multiple organs, physiologically elicit fine tuning of systemic energy metabolism.
Department of Rheumatology, Center for Antibody and Vaccine Therapy, IMSUT Hospital, Institute of Medical Science, University of Tokyo, Japan. Electronic address: hirotnk@ims.u-tokyo.ac.jp.
Hirotoshi
H
Tanaka
Department of Rheumatology, Center for Antibody and Vaccine Therapy, IMSUT Hospital, Institute of Medical Science, University of Tokyo, Japan.
Noriaki
N
Shimizu
Department of Rheumatology, Center for Antibody and Vaccine Therapy, IMSUT Hospital, Institute of Medical Science, University of Tokyo, Japan.
Noritada
N
Yoshikawa
D000818:Animals; D004734:Energy Metabolism; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*
D011965:Receptors, Glucocorticoid
Alanine; Amino acid; FGF21; Glucocorticoid; KLF15; Nuclear receptor; REDD1; mTOR