Use of hepatobiliary phase images in Gd-EOB-DTPA-enhanced MRI of breast cancer hepatic metastasis to predict response to chemotherapy.
OBJECTIVE
To determine the prognostic value of Gd-EOB-DTPA MRI findings of liver metastasis from breast cancer.


METHODS
29 metastatic lesions from 12 breast cancer patients who received chemotherapy were retrospectively reviewed. We evaluated hepatobiliary phase of the lesions and classified them as a "target" or "non-target" appearance. The relationship of appearance or SI ratio with tumor response was analyzed.


RESULTS
A non-target appearance was more frequent in disease control group than in non-control group [14/18 (77.8%) vs. 4/18 (22.2%)], and it was associated with a better response [p=0.048].


CONCLUSIONS
HBP analysis may be useful to predict the response to chemotherapy and survival.
Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Hyun Ji
HJ
Lee
Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address: chlee86@korea.ac.kr.
Chang Hee
CH
Lee
Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Jeong Woo
JW
Kim
Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Yang Shin
YS
Park
Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Jongmee
J
Lee
Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Kyeong Ah
KA
Kim
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001659:Biliary Tract / Q000000981:diagnostic imaging* / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D005682:Gadolinium; D019786:Gadolinium DTPA
Breast cancer liver metastases; Chemotherapy response; Gadoxetic acid; Hepatobiliary phase (HBP); MRI