[Research progression of the relationship between integrin α2β1 and drug-induced gingival overgrowth].
Drug-induced gingival overgrowth (DIGO) is characterized by fibrous gingival hyperplasia and increased gingival volume. DIGO is histologically associated with proliferation of cells and deposition of extracellular matrices, particularly collagen. Integrin α2β1 is related to collagen phagocytosis and involved in the occurrence and progression of DIGO. This paper reviews the progress of research on the relationship between integrin α2β1 and DIGO.
State Key Laboratory of Oral Diseases, Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Kang
K
Yingzhu
State Key Laboratory of Oral Diseases, Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Guo
G
Shujuan
State Key Laboratory of Oral Diseases, Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Liu
L
Chengcheng
State Key Laboratory of Oral Diseases, Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Ding
D
Yi
D003094:Collagen; D005881:Gingiva; D019214:Gingival Overgrowth; D006801:Humans; D038982:Integrin alpha2beta1; D010587:Phagocytosis
D038982:Integrin alpha2beta1; D003094:Collagen
collagen phagocytosis; collagens metabolism; drug-induced gingival overgrowth; integrin α2β1