Hormesis commonly observed in the assessment of aneuploidy in yeast.
Extensive dose response studies have assessed the potential of toxic chemical agents to induce aneuploidy in the yeast model. An assessment of such findings revealed that hormetic-like biphasic dose responses were commonly observed. A preliminary estimate of the frequency of the hormetic responses using a priori entry and evaluative criteria was approximately 65-80%.
Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, United States. Electronic address: edwardc@schoolph.umass.edu.
Edward J
EJ
Calabrese
D000782:Aneuploidy; D004305:Dose-Response Relationship, Drug; D059165:Hormesis; D018570:Risk Assessment; D015003:Yeasts / Q000235:genetics / Q000502:physiology*
Aneuploidy; Biphasic dose response; Genotoxicity; Hormesis; Yeast