Automated segmentation of MR imaging to determine normative central nervous system cerebrospinal fluid volumes in healthy volunteers.
An accurate non-invasive method to determine total body cerebrospinal fluid volume has a number of potential diagnostic and therapeutic applications. Herein we describe a technique for automated segmentation of total body MRI data to determine cranial and spinal CSF volume in 15 healthy adults. These in vivo estimates of CSF volume exceed the standard reported volume of 150mL in human adults and provide normative data for diagnosis of disease states such as hydrocephalus and therapy including pharmacologic dosimetry. No correlation was observed between patient height or weight and total body CSF volume.
Department of Radiology, Weill Cornell Medicine, 525 East 68th Street, New York, NY 10065, USA. Electronic address: jlc2008@med.cornell.edu.
J Levi
JL
Chazen
Department of Radiology, Weill Cornell Medicine, 525 East 68th Street, New York, NY 10065, USA. Electronic address: jpd2001@med.cornell.edu.
Jonathan P
JP
Dyke
inviCRO, LLC, 27 Drydock Ave., 7th Floor West, Boston, MA 02210, USA. Electronic address: rholt@invicro.com.
Robert W
RW
Holt
Biogen, Inc, 250 Binney Street, Cambridge, MA 02142, USA. Electronic address: lhorky@hotmail.com.
Laura
L
Horky
inviCRO, LLC, 27 Drydock Ave., 7th Floor West, Boston, MA 02210, USA. Electronic address: rpauplis@invicro.com.
Rachel A
RA
Pauplis
inviCRO, LLC, 27 Drydock Ave., 7th Floor West, Boston, MA 02210, USA. Electronic address: hesterman@invicro.com.
Jacob Y
JY
Hesterman
Department of Radiology, Weill Cornell Medicine, 525 East 68th Street, New York, NY 10065, USA. Electronic address: mozley@med.cornell.edu.
David P
DP
Mozley
Biogen, Inc, 250 Binney Street, Cambridge, MA 02142, USA. Electronic address: averma@unitedneuroscience.com.
Ajay
A
Verma
D000328:Adult; D002490:Central Nervous System / Q000000981:diagnostic imaging* / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000000981:diagnostic imaging*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid / Q000175:diagnosis; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D055815:Young Adult
Brain; CSF; Cerebrospinal fluid; Spinal cord