Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model.
Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with high morbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia. Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunction with perinatal asphyxia on the basis of updated evidence from an experimental model.
Centro de Investigaciones en Psicología y Psicopedagogía, Facultad de Psicología, Universidad Católica Argentina, Buenos Aires, Argentina; Instituto de Investigaciones Cardiológicas (ININCA), UBA-CONICET, CABA, Buenos Aires, Argentina.
María Inés
MI
Herrera
Instituto de Investigaciones Cardiológicas (ININCA), UBA-CONICET, CABA, Buenos Aires, Argentina.
Matilde
0000-0001-6650-1033
M
Otero-Losada
Instituto de Investigaciones Cardiológicas (ININCA), UBA-CONICET, CABA, Buenos Aires, Argentina.
Lucas Daniel
LD
Udovin
Instituto de Investigaciones Cardiológicas (ININCA), UBA-CONICET, CABA, Buenos Aires, Argentina.
Carlos
C
Kusnier
Instituto de Investigaciones Cardiológicas (ININCA), UBA-CONICET, CABA, Buenos Aires, Argentina.
Rodolfo
R
Kölliker-Frers
Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Wanderley
W
de Souza
Centro de Investigaciones en Psicología y Psicopedagogía, Facultad de Psicología, Universidad Católica Argentina, Buenos Aires, Argentina; Instituto de Investigaciones Cardiológicas (ININCA), UBA-CONICET, CABA, Buenos Aires, Argentina; Departamento de Biología, Universidad Argentina JF Kennedy, Buenos Aires, Argentina; Universidad Autónoma de Chile, Santiago de Chile, Chile.
Francisco
0000-0003-0342-0628
F
Capani
D000818:Animals; D001238:Asphyxia Neonatorum / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D009422:Nervous System Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D013569:Synapses / Q000378:metabolism / Q000473:pathology*