Downstream overdrive pacing and intracardiac concealed fusion to guide rapid identification of atrial tachycardia after atrial fibrillation ablation.
Atrial tachycardia (AT) related to atrial fibrillation (AF) ablation frequently poses a diagnostic challenge. Downstream overdrive pacing (DOP) can be used to rapidly detect reentry and assess proximity of a pacing site to an AT circuit or focus. We hypothesized that systematic DOP using multielectrode catheters would facilitate AT mapping.



DOP identified constant fusion when the post-pacing interval (PPI)-tachycardia cycle length (TCL) <40 ms and stimulus to adjacent upstream atrial electrogram interval >75% of TCL. Mapping was performed as follows: (i) CS DOP, (ii) DOP at left atrial (LA) roof, (iii) DOP at selected LA sites based on prior DOP attempts, and (iv) mapping and ablation at regions of fractionated electrograms in region of AT. Activation mapping was performed at operator discretion. AT diagnosis was confirmed by successful ablation or additional mapping when ablation was unsuccessful. Fifty consecutive patients with sustained AT underwent mapping of 68 ATs, of whom 42 (62%) were macroreentrant, 19 were locally reentrant (28%), and 7 (10%) were focal. AT was correctly identified with a median of three DOP attempts. All macroreentrant ATs were identified with ≤6 DOP attempts. One AT (1.6%) was terminated by DOP, and three ATs (4.8%) required activation mapping. Intracardiac concealed fusion was seen in 26 ATs (38%), each of which was successfully ablated.



Reentry could be demonstrated in a substantial majority of AF ablation-related AT. A stepwise diagnostic approach using DOP and recognition of intracardiac concealed fusion can be used to rapidly identify and ablate reentrant AT.
Leon H. Charney Division of Cardiology, New York University Langone Medical Center, New York, NY, USA.
Chirag R
CR
Barbhaiya
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
Samuel H
SH
Baldinger
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
Saurabh
S
Kumar
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
Jason S
JS
Chinitz
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
Alan D
AD
Enriquez
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
Roy
R
John
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
William G
WG
Stevenson
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
Gregory F
GF
Michaud
D000200:Action Potentials; D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D006328:Cardiac Catheterization / Q000295:instrumentation; D062906:Cardiac Catheters; D002304:Cardiac Pacing, Artificial; D017115:Catheter Ablation / Q000009:adverse effects*; D022062:Electrophysiologic Techniques, Cardiac / Q000295:instrumentation; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011237:Predictive Value of Tests; D012307:Risk Factors; D013617:Tachycardia, Supraventricular / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome