Kinetics of expression of genes involved in glucose metabolism after the last meal in overfed mule ducks.
In waterfowls, overfeeding leads to a hepatic steatosis, also called "foie gras." We decided to investigate the role of glucose metabolism in steatosis emergence. For this, we measured the expression of genes during the 12 h following the last meal of the overfeeding period. As expected, it showed that the expression of glucose transporter is more precocious in jejunal mucosa, especially for SGLT1, known to be the major transporter at the apical surface. In the liver, GLUT2 and HK1 are upregulated at the same time and seem to work together to import glucose. In peripherals tissues, such as muscle and subcutaneous adipose tissue (SAT), expression of genes of interest occurs later than the one in jejunum and liver. These results are in accordance with the evolution of glycemia. This study allows us to better understand the kinetic treatment of glucose after a meal in overfed ducks. It also will allow researchers to better target their sampling time knowing the optimal point of expression of each gene.
UMR 1419 INRA UPPA NuMéA, 371 Rue du Ruisseau, 40000, Mont de Marsan, France.|UMR 1419 INRA UPPA NuMéA, Quartier Ibarron, 64310, Saint Pée sur Nivelle, France.
Tavernier
T
Annabelle
UMR 1419 INRA UPPA NuMéA, 371 Rue du Ruisseau, 40000, Mont de Marsan, France.|UMR 1419 INRA UPPA NuMéA, Quartier Ibarron, 64310, Saint Pée sur Nivelle, France.
Ricaud
R
Karine
INRA UEPFG, 1076 Route de Haut Maucq, 40280, Benquet, France.
Bernadet
B
Marie-Dominique
UMR 1419 INRA UPPA NuMéA, 371 Rue du Ruisseau, 40000, Mont de Marsan, France.|UMR 1419 INRA UPPA NuMéA, Quartier Ibarron, 64310, Saint Pée sur Nivelle, France.
Davail
D
Stéphane
UMR 1419 INRA UPPA NuMéA, 371 Rue du Ruisseau, 40000, Mont de Marsan, France. karine.gontier@univ-pau.fr.|UMR 1419 INRA UPPA NuMéA, Quartier Ibarron, 64310, Saint Pée sur Nivelle, France. karine.gontier@univ-pau.fr.
Gontier
G
Karine
D000818:Animals; D030161:Avian Proteins / Q000378:metabolism*; D004372:Ducks / Q000378:metabolism*; D005234:Fatty Liver / Q000378:metabolism* / Q000473:pathology; D051273:Glucose Transporter Type 2 / Q000378:metabolism*; D006943:Hyperglycemia / Q000378:metabolism*; D051269:Sodium-Glucose Transporter 1 / Q000378:metabolism*
D030161:Avian Proteins; D051273:Glucose Transporter Type 2; D051269:Sodium-Glucose Transporter 1
Ducks; Glucose metabolism; Hepatic steatosis; Kinetic