A story of birth and death: Insights into the formation and dynamics of the microglial population.
Microglia are the main resident immunocompetent cells of the brain with key roles in brain development, homeostasis and function. Here we briefly review our current knowledge of the homeostatic mechanisms regulating the composition and turnover of the microglial population under physiological conditions from development to ageing. A greater understanding of these mechanisms may inform understanding of how dysregulation of microglial dynamics could contribute to the pathogenesis and/or progression of neurological disorders.
Biological Sciences, Southampton General Hospital, University of Southampton, United Kingdom.
Katharine
K
Askew
Biological Sciences, Southampton General Hospital, University of Southampton, United Kingdom. Electronic address: d.gomez-nicola@soton.ac.uk.
Diego
D
Gomez-Nicola
D000818:Animals; D001921:Brain / Q000166:cytology* / Q000473:pathology; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D017628:Microglia / Q000166:cytology* / Q000473:pathology