miR-429 mediates tumor growth and metastasis in colorectal cancer.
Colorectal cancer (CRC), presenting the third most common malignancy worldwide. In recent years, the aberrantly upregulation or downregulation of miRNAs in CRC have been evidenced in a number of studies. In this study, our results showed that the expression of miR-429 was significantly higher in CRC tissue compared with adjacent non-tumor tissue. In addition, our findings showed that miR-429 level was significantly associated with clinicoplathological features and prognosis of patients with CRC. Moreover, our findings showed that miR-429 exerted oncogenic effect by directly targeting HOXA5, a transcription factor of HOX families that is involved in the development and progression of CRC.
Qingdao University Qingdao 266071, Shandong, China.
Yantao
Y
Han
Qingdao University Affiliated Hospital Qingdao 266071, Shandong, China.
Qian
Q
Zhao
Qingdao University Affiliated Hospital Qingdao 266071, Shandong, China.
Jie
J
Zhou
Qingdao Hiser Medical Center Qingdao 266033, Shandong, China.
Rui
R
Shi
CRC; HOXA5; MiR-429; metastasis; tumor growth