Roles of CDK and DDK in Genome Duplication and Maintenance: Meiotic Singularities.
Cells reproduce using two types of divisions: mitosis, which generates two daughter cells each with the same genomic content as the mother cell, and meiosis, which reduces the number of chromosomes of the parent cell by half and gives rise to four gametes. The mechanisms that promote the proper progression of the mitotic and meiotic cycles are highly conserved and controlled. They require the activities of two types of serine-threonine kinases, the cyclin-dependent kinases (CDKs) and the Dbf4-dependent kinase (DDK). CDK and DDK are essential for genome duplication and maintenance in both mitotic and meiotic divisions. In this review, we aim to highlight how these kinases cooperate to orchestrate diverse processes during cellular reproduction, focusing on meiosis-specific adaptions of their regulation and functions in DNA metabolism.
Genome Duplication and Maintenance Team, Institute of Genetics and Development of Rennes, CNRS UMR 6290, 2 av. du Pr. Léon Bernard, 35043 Rennes. blanca.gomez.escoda@gmail.com.
Blanca
B
Gómez-Escoda
Genome Duplication and Maintenance Team, Institute of Genetics and Development of Rennes, CNRS UMR 6290, 2 av. du Pr. Léon Bernard, 35043 Rennes. pei-yun.wu@univ-rennes1.fr.
Pei-Yun Jenny
PJ
Wu
Dbf4-dependent kinase; cyclin-dependent kinase; genome duplication; meiosis; meiotic recombination; mitosis; quantitative model