S100A6 - focus on recent developments.
The Ca2+-binding protein, S100A6, belongs to the S100 family. Binding of Ca2+ induces a conformational change, which causes an increase in the overall S100A6 hydrophobicity and allows it to interact with many targets. S100A6 is expressed in different normal tissues and in many tumors. Up to now it has been shown that S100A6 is involved in cell proliferation, cytoskeletal dynamics and tumorigenesis, and that it might have some extracellular functions. In this review, we summarize novel discoveries concerning S100A6 targets, its involvement in cellular signaling pathways, and presence in stem/progenitor cells, extracellular matrix and body fluids of diseased patients.
Wiesława
W
Leśniak
Tomasz
T
Wilanowski
Anna
A
Filipek
D000818:Animals; D001826:Body Fluids / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009418:S100 Proteins / Q000378:metabolism*; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism
D009418:S100 Proteins; D002118:Calcium
S100 family; S100A6 (calcyclin); body fluids; pathology; stem/progenitor cells; tumor