Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging.
We describe the synthesis, characterization and application as contrast agents in magnetic resonance imaging of a novel type of magnetic nanoparticle based on Gd-Si oxide, which presents high Gd3+atom density. For this purpose, we have used a Prussian Blue analogue as the sacrificial template by reacting with soluble silicate, obtaining particles with nanorod morphology and of small size (75 nm). These nanoparticles present good biocompatibility and higher longitudinal and transversal relaxivity values than commercial Gd3+solutions, which significantly improves the sensitivity ofin vivomagnetic resonance images.
Instituto de Tecnología Química, Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Avenida de los Naranjos s/n, 46022 Valencia, Spain. alcabgar@itq.upv.es.
Alejandro
A
Cabrera-García
Instituto de Tecnología Química, Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Avenida de los Naranjos s/n, 46022 Valencia, Spain. svidal@itq.upv.es.
Alejandro
A
Vidal-Moya
Unit of Magnetic Resonance Imaging, Hospital Universitario de Alicante, INSCANNER S.L., Alicante, Spain. angela.bernabeu@gmail.com.
Ángela
Á
Bernabeu
Unit of Functional Magnetic Resonance Imaging, Instituto de Neurociencias (CSIC-UMH), Alicante, Spain. jpacheco@umh.es.
Jesús
J
Pacheco-Torres
Institute of Bioengineering, Universidad Miguel Hernández, Elche, Spain and Centre for Network Biomedical Research (CIBER-BBN), Spain. echeca@goumh.umh.es.
Elisa
E
Checa-Chavarria
Institute of Bioengineering, Universidad Miguel Hernández, Elche, Spain and Centre for Network Biomedical Research (CIBER-BBN), Spain. e.fernandez@umh.es.
Eduardo
E
Fernández
Instituto de Tecnología Química, Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Avenida de los Naranjos s/n, 46022 Valencia, Spain. pbotella@itq.upv.es.
Pablo
P
Botella
Gd-Si nanoparticles; Prussian Blue analogues; contrast agent; magnetic resonance imaging