Gold Nanoparticles: An Efficient Antimicrobial Agent against Enteric Bacterial Human Pathogen.
Enteric bacterial human pathogens,i.e., Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Klebsiella pneumoniae, are the major cause of diarrheal infections in children and adults. Their structure badly affects the human immune system. It is important to explore new antibacterial agents instead of antibiotics for treatment. This project is an attempt to explain how gold nanoparticles affect these bacteria. We investigated the important role of the mean particle size, and the inhibition of a bacterium is dose-dependent. Ultra Violet (UV)-visible spectroscopy revealed the size of chemically synthesized gold nanoparticle as 6-40 nm. Atomic force microscopy (AFM) analysis confirmed the size and X-ray diffractometry (XRD) analysis determined the polycrystalline nature of gold nanoparticles. The present findings explained how gold nanoparticles lyse Gram-negative and Gram-positive bacteria.
Department of Physics, University of Engineering & Technology, Lahore 54890, Pakistan. drshamaila.uet@gmail.com.
Shahzadi
S
Shamaila
Department of Physics, University of Engineering & Technology, Lahore 54890, Pakistan. noshin_zafer@yahoo.com.
Noshin
N
Zafar
Centre for Excellence in Solid State Physics, University of Punjab, Lahore 54590, Pakistan. saira.cssp@pu.edu.pk.
Saira
S
Riaz
Department of Physics, University of Engineering & Technology, Lahore 54890, Pakistan. rsharif2002@yahoo.com.
Rehana
R
Sharif
Department of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan. jawad.nazir@uvas.edu.pk.
Jawad
J
Nazir
Centre for Excellence in Solid State Physics, University of Punjab, Lahore 54590, Pakistan. shahzad_naseem@yahoo.com.
Shahzad
S
Naseem
chemical reduction method; enteric bacterial human pathogens; gold nanoparticles; gram-negative and gram-positive bacteria