Association of NAFLD With Diabetes and the Impact of BMI Changes: A 5-Year Cohort Study Based on 18,507 Elderly.
Previous studies about the relationship between nonalcoholic fatty liver disease (NAFLD) and diabetes are limited by inconsistent conclusions, mainly being cross-sectional and having a small sample size, no elderly people, or a lack of prediabetes.



This study sought to examine the relationship between NAFLD and diabetes and prediabetes in a large cohort based on Chinese male elderly.



This was a retrospective cohort study that was followed up for ∼5 years.



This study was conducted in Beijing, China.



Chinese male elderly (n = 18,507). Participants with diabetes/prediabetes at baseline were excluded.



Ultrasound was used for diagnosis of NAFLD.



Mean age of the 18,507 participants was 71.38 ± 14.15 years. The prevalence of NAFLD was 18.77% (3474/18,503), and participants with NAFLD had higher body mass index (BMI), blood pressure levels, blood lipid levels, and also higher alanine aminotransferase levels (P < 0.001). The total 5-year incidence was 2.448% for diabetes and 10.628% for prediabetes. Participants with NAFLD at baseline had a higher incidence of both diabetes and prediabetes. The adjusted relative risks (RRs) were 1.672 [95% confidence interval (CI), 1.361 to 2.052] and 1.336 (95% CI, 1.205 to 1.481). The RRs were closely related to BMI changes. The adjusted RRs for diabetes according to three BMI change groups (<-1.00 kg/m2, -1.00 to 1.00 kg/m2, >1.00 kg/m2) were 1.599 (95% CI, 1.054 to 2.426), 1.640 (95% CI, 1.241 to 2.167), and 1.918 (95% CI, 1.239 to 2.969), respectively. Similar results were obtained when prediabetes was used as the dependent variable.



There was a strong and independent association between NAFLD and both diabetes and prediabetes among Chinese male elderly, and this relationship was closely related to BMI changes.
Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics and.
Miao
M
Liu
Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics and.
Jianhua
J
Wang
Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics and.
Jing
J
Zeng
Department of Health and Economics, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Xiutang
X
Cao
Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics and.
Yao
Y
He
D000368:Aged; D000369:Aged, 80 and over; D000068476:Beijing / Q000453:epidemiology; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000453:epidemiology*; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D050177:Overweight / Q000150:complications / Q000453:epidemiology; D011236:Prediabetic State / Q000150:complications / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies