Prolonged P-Wave and QT Dispersion in Children with Inflammatory Bowel Disease in Remission.
Objectives.Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) with unclear underlying aetiologies. Severe cardiac arrhythmias have been emphasised in a few studies on adult IBD patients. This study aimed to investigate the alteration of the P-wave and QT interval dispersion parameters to assess the risk of atrial conduction and ventricular repolarisation abnormalities in pediatric IBD patients.Patients and Methods.Thirty-six IBD patients in remission (UC: 20, CD: 16) aged 3-18 years and 36 age- and sex-matched control patients were enrolled in the study. Twelve-lead electrocardiograms were used to determine durations of P-wave, QT, and corrected QT (QTc) interval dispersion. Transthoracic echocardiograms and 24-hour rhythm Holter recordings were obtained for both groups.Results.The P-wave dispersion, QT dispersion, and QTc interval dispersion (Pdisp, QTdisp, and QTcdisp) were significantly longer in the patient group. The mean values of Pminimum, Pmaximum, and QTcminimum were significantly different between the two groups. The echocardiography and Holter monitoring results were not significantly different between the groups. Furthermore, no differences in these parameters were detected between the CD and UC groups.Conclusion.Results suggest that paediatric IBD patients may carry potential risks for serious atrial and ventricular arrhythmias over time even during remission.
Department of Pediatric Cardiology, Kanuni Sultan Süleyman Education and Research Hospital, İstanbul, Turkey.
Helen Aghdasi
0000-0003-3471-4266
HA
Bornaun
Department of Pediatric Cardiology, Medical Faculty, Mustafa Kemal University, Hatay, Turkey.
Nuh
N
Yılmaz
Department of Pediatric Gastroenterology, Kanuni Sultan Süleyman Education and Research Hospital, İstanbul, Turkey.
Günsel
G
Kutluk
Department of Pediatric Cardiology, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul, Turkey.
Reyhan
R
Dedeoğlu
Department of Pediatric Cardiology, Kanuni Sultan Süleyman Education and Research Hospital, İstanbul, Turkey.
Kazım
K
Öztarhan
Department of Pediatrics, Kanuni Sultan Süleyman Education and Research Hospital, İstanbul, Turkey.
Gonca
0000-0003-1797-2802
G
Keskindemirci
Department of Pediatrics, Kanuni Sultan Süleyman Education and Research Hospital, İstanbul, Turkey.
Aras
A
Tulunoğlu
Department of Pediatric Cardiology, Medical Faculty, Necmettin Erbakan University, Konya, Turkey.
Fatih
F
Şap
D000293:Adolescent; D001145:Arrhythmias, Cardiac / Q000150:complications* / Q000503:physiopathology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000150:complications* / Q000503:physiopathology; D003424:Crohn Disease / Q000150:complications* / Q000503:physiopathology; D004452:Echocardiography; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D008133:Long QT Syndrome / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D012074:Remission Induction; D012306:Risk