Interaction of renal cortical cyclooxygenase-2 and angiotensin II in postnatal nephrogenesis.
Both renal cortical cyclooxygenase 2 (COX-2) and angiotensin II (Ang II) are involved in postnatal nephrogenesis and maturation. Crosstalk between renal cortical COX-2 and Ang II exists in the adult kidney. However, the potential role of the interaction between renal cortical COX-2 and Ang II in postnatal nephrogenesis and maturation has not been previously investigated. A study by Frölich et al. now strongly indicates that cortical COX-2 promotes postnatal nephrogenesis and maturation through activation of Ang II-angiotensin type 1 receptor signaling.
Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Vanderbilt Center for Kidney Disease, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Electronic address: ming-zhi.zhang@vanderbilt.edu.
Ming-Zhi
MZ
Zhang
D000804:Angiotensin II; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D006801:Humans; D007668:Kidney; D044140:Receptor, Angiotensin, Type 1
D052246:Cyclooxygenase 2 Inhibitors; D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II; D051546:Cyclooxygenase 2