Strategies to improve stimulation efficiency for retinal prostheses.
Retinitis Pigmentosa (RP) is a degenerative disease of the retina that leads to vision loss. Retinal prostheses are being developed in order to restore functional vision in patients suffering from RP. We conducted in-vivo experiments in order to identify strategies to efficiently stimulate the retina. We electrically stimulated the retina and measured electrically evoked potentials (EERs) from the superior colliculus of rats. We compared the strength of EERs when voltage-controlled and current-controlled pulses of varying pulse width and charge levels were applied to the retina. In addition to comparing EER strength, we evaluated improvement in power efficiency afforded by a high surface area platinum-iridium material. Voltage-controlled pulses were more efficient than current-controlled pulses when the pulses have a short duration (<; 1 ms) and current-controlled pulses were more efficient than voltage-controlled pulses when the pulse width was greater than 1 ms. The high surface area platinum-iridium stimulation electrode consumed power significantly lower than a standard platinum-iridium electrode.
Navya S
NS
Davuluri
Kiran
K
Nimmagadda
Artin
A
Petrossians
Mark S
MS
Humayun
James D
JD
Weiland
D000818:Animals; D004195:Disease Models, Animal; D004558:Electric Stimulation; D005071:Evoked Potentials; D051381:Rats; D012160:Retina / Q000502:physiology*; D012174:Retinitis Pigmentosa / Q000628:therapy*; D057488:Visual Prosthesis