Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor-Deficient Mice.
Whole-body vibration (WBV) has gained attention as a potential exercise mimetic, but direct comparisons with the metabolic effects of exercise are scarce. To determine whether WBV recapitulates the metabolic and osteogenic effects of physical activity, we exposed male wild-type (WT) and leptin receptor-deficient (db/db) mice to daily treadmill exercise (TE) or WBV for 3 months. Body weights were analyzed and compared with WT and db/db mice that remained sedentary. Glucose and insulin tolerance testing revealed comparable attenuation of hyperglycemia and insulin resistance in db/db mice following TE or WBV. Both interventions reduced body weight in db/db mice and normalized muscle fiber diameter. TE or WBV also attenuated adipocyte hypertrophy in visceral adipose tissue and reduced hepatic lipid content in db/db mice. Although the effects of leptin receptor deficiency on cortical bone structure were not eliminated by either intervention, exercise and WBV increased circulating levels of osteocalcin in db/db mice. In the context of increased serum osteocalcin, the modest effects of TE and WBV on bone geometry, mineralization, and biomechanics may reflect subtle increases in osteoblast activity in multiple areas of the skeleton. Taken together, these observations indicate that WBV recapitulates the effects of exercise on metabolism in type 2 diabetes.
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Meghan E
ME
McGee-Lawrence
Department of Orthopedic Surgery, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Karl H
KH
Wenger
Department of Pediatrics, Gastroenterology Division, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Sudipta
S
Misra
Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.|Physiology Department, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Catherine L
CL
Davis
Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.|Physiology Department, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Norman K
NK
Pollock
Department of Oral Biology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Mohammed
M
Elsalanty
Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Kehong
K
Ding
Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Carlos M
CM
Isales
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Mark W
MW
Hamrick
Physiology Department, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Marlena
M
Wosiski-Kuhn
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Phonepasong
P
Arounleut
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224.
Mark P
MP
Mattson
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224.
Roy G
RG
Cutler
Department of Surgery, Plastic Surgery Division, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Jack C
JC
Yu
Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Alexis M
AM
Stranahan
D017667:Adipocytes / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000235:genetics* / Q000378:metabolism / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D004734:Energy Metabolism / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009133:Muscular Atrophy / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control; D010805:Physical Conditioning, Animal / Q000502:physiology*; D054411:Receptors, Leptin / Q000235:genetics*; D014732:Vibration / Q000627:therapeutic use*
D054411:Receptors, Leptin; C515447:leptin receptor, mouse