High-frequency QRS analysis in the evaluation of chest pain in the emergency department.
High frequency QRS (HFQRS) analysis has been shown to be an accurate marker for myocardial ischemia. Our objective was to test the use of HFQRS in diagnosing ACS in the emergency department.



324 patients presenting to the ED with chest pain were enrolled. Resting ECG was recorded and later analyzed by an HFQRS algorithm. Results were compared to the conventional ECG diagnosis by 3 independent interpretations: treating physician, expert cardiologist and an automated computer program.



The HFQRS analysis demonstrated improved sensitivity (67.5%) for the NSTE-ACS group compared to the human interpreters (59.7% and 53.2% for the treating physician and cardiologist respectively) with similar specificity. The automatic program had significantly lower sensitivity (31%) with a higher specificity (77%).



HFQRS which has shown great promise in diagnosing stable CAD may also be helpful in the ED for diagnosing ACS.
Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev Beer Sheva, Israel. Electronic address: ori.galante@gmail.com.
Ori
O
Galante
Biological Signal Processing Ltd, Tel-Aviv, Israel.
Guy
G
Amit
Biological Signal Processing Ltd, Tel-Aviv, Israel.
Yair
Y
Granot
Biological Signal Processing Ltd, Tel-Aviv, Israel.
Linda R
LR
Davrath
Tel-Aviv University, Tel-Aviv, Israel.
Shimon
S
Abboud
Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev Beer Sheva, Israel.
Doron
D
Zahger
D054058:Acute Coronary Syndrome / Q000175:diagnosis*; D002637:Chest Pain / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004562:Electrocardiography / Q000379:methods*; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
Acute coronary syndrome; Acute myocardial infarction; Chest pain; Electrocardiography; High-frequency ECG; Myocardial ischemia