Cutaneous T-cell lymphoma-associated Leser-Trélat sign: report and world literature review.
BACKGROUND
The sign of Leser-Trélat is characterizedby the sudden appearance of seborrheic keratosesassociated with an underlying malignancy.


OBJECTIVE
An elderly man who developed multiple new-onsetseborrheic keratoses temporally associated witha diagnosis of mycosis fungoides is described andlymphoma-associated Leser-Trélat sign is reviewed.


METHODS
Pubmed was used to search the followingterms: cutaneous T-cell lymphoma, Leser-Trélat,leukemia, lymphoma, mycosis fungoides, and Sézarysyndrome. Papers with these terms and referencescited within these papers were reviewed.


RESULTS
An 84-year-old man developed multiple seborrheickeratoses temporally associated with a diagnosisof mycosis fungoides is presented. He was treatedwith bexarotene and achieved clinical remission;the number of seborrheic keratoses also decreased.Lymphoma-associated Leser-Trélat sign has beenobserved not only with mycosis fungoides but alsoother lymphomas and leukemias.


CONCLUSIONS
Thesign of Leser-Trélat is predominantly associated withsolid organ adenocarcinomas. Albeit less common, aneruptive onset of seborrheic keratoses can also occurin association with hematopoietic malignancies.
School of Medicine, University of California San Diego. sindhunarala@gmail.com.
Saisindhu
S
Narala
Philip R
PR
Cohen
D000369:Aged, 80 and over; D006801:Humans; D017492:Keratosis, Seborrheic / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D008297:Male; D009182:Mycosis Fungoides / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology