The usefulness of combined assessment of E/E' ratio and transmitral flow pattern to interpret cardiac condition.
High mitral inflow early (E) velocity to tissue Doppler E' ratio (E/E') and an E to late diastolic filling velocity ratio (E/A) are used to evaluate left ventricular (LV) diastolic function and filling pressure, but the usefulness of combined assessment of E/E' and E/A is not fully understood.　Methods: We retrospectively analyzed 1,266 patients who underwent echocardiography to assess cardiac function.　Patients were grouped based on the values of E/E' (low E/E'<15, high E/E'≥15) and E/A (low E/A≤0.8, high E/A>0.8).　Results: High E/E' with both high and low E/A groups showed lower LV ejection fraction and higher LV mass index compared to low E/E' with both high and low E/A groups.　High E/E' with both high and low E/A groups showed slower E' velocity and larger left atrial volume index compared to low E/E' with both high and low E/A groups, but high E/E' with low E/A group exhibited smaller left atrial volume index and higher pulmonary venous systolic to diastolic peak velocity ratio compared to high E/E' with high E/A group.　Moreover, high E/E' with low E/A group displayed lower tricuspid regurgitant pressure gradient than the high E/E' with high E/A group.　Conclusion: Even in the situation of high E/E', low E/A condition indicated lower LV filling pressure and controlled fluid retention.
Department of Cardiovascular Medicine, Fukushima Medical University.
Masayoshi
M
Oikawa
Department of Cardiovascular Medicine, Fukushima Medical University.
Atsushi
A
Kobayashi
Department of Cardiovascular Medicine, Fukushima Medical University.
Takamasa
T
Sato
Department of Cardiovascular Medicine, Fukushima Medical University.
Satoshi
S
Suzuki
Department of Cardiovascular Medicine, Fukushima Medical University.
Yoshihisa
Y
Akiomi
Department of Cardiovascular Medicine, Fukushima Medical University.
Kazuhiko
K
Nakazato
Department of Cardiovascular Medicine, Fukushima Medical University.
Hitoshi
H
Suzuki
Department of Cardiovascular Medicine, Fukushima Medical University.
Shu-Ichi
SI
Saitoh
Department of Cardiovascular Medicine, Fukushima Medical University.
Yasuchika
Y
Takeishi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000503:physiopathology; D006334:Heart Function Tests / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D013599:Systole; D016277:Ventricular Function, Left / Q000502:physiology*; D020257:Ventricular Remodeling
Cardiac hypertrophy; Cardiac remodeling; Diastolic function; Tissue Doppler echocardiography