Simulation Study of an Ultrasound Retinal Prosthesis With a Novel Contact-Lens Array for Noninvasive Retinal Stimulation.
Millions of people around the world suffer from varying degrees of vision loss (including complete blindness) because of retinal degenerative diseases. Artificial retinal prosthesis, which is usually based on electrical neurostimulation, is the most advanced technology for different types of retinal degeneration. However, this technology involves placing a device into the eyeball, and such a highly invasive procedure is inevitably highly risk and expensive. Ultrasound has been demonstrated to be a promising technology for noninvasive neurostimulation, making it possible to stimulate the retina and induce action potentials similar to those elicited by light stimulation. However, the technology of ultrasound retinal stimulation still requires considerable developments before it could be applied clinically. This paper proposes a novel contact-lens array transducer for use in an ultrasound retinal prosthesis (USRP). The transducer was designed in the shape of a contact lens so as to facilitate acoustic coupling with the eye liquid. The key parameters of the ultrasound transducer were simulated, and results are presented that indicate the achievement of 2-D pattern generation and that the proposed contact-lens array is suitable for multiple-focus neurostimulation, and can be used in a USRP.
Mengdi
M
Gao
Yanyan
Y
Yu
Huixia
H
Zhao
Guofeng
G
Li
Hongyang
H
Jiang
Congzhi
C
Wang
Feiyan
F
Cai
Leanne Lai-Hang
LL
Chan
Bernard
B
Chiu
Wei
W
Qian
Weibao
W
Qiu
Hairong
H
Zheng
D003198:Computer Simulation; D017076:Computer-Aided Design; D003261:Contact Lenses; D004599:Electric Stimulation Therapy / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D058542:Implantable Neurostimulators; D008962:Models, Theoretical; D011829:Radiation Dosage; D015203:Reproducibility of Results; D012160:Retina / Q000502:physiology* / Q000528:radiation effects; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D014159:Transducers; D014464:Ultrasonic Therapy / Q000295:instrumentation* / Q000379:methods; D000069453:Ultrasonic Waves; D057488:Visual Prosthesis