SCREENING OF WILD FRUIT TREES WITH GASTROPROTECTIVE ACTIVITY IN DIFFERENT EXPERIMENTAL MODELS.
BACKGROUND
Given the increase of people with gastrointestinal disorders, the search for alternative treatments with fewer side effects is vital, as well as the demand for food or plants that can help protect the stomach.


OBJECTIVE
The aim of this study was to evaluate the gastroprotective action of the extracts of wild fruit trees of Myrcianthes pungens (guabiju); Inga vera Willd. (ingá-banana) and Marlierea tomentosa Cambess. (guarapuruna) in in vivo pharmacological models.


METHODS
The different parts of the fruits were separately subjected to a process of extraction by methanol. Two experimental pharmacological models were conducted in mice; the gastric ulcer model induced by non-steroidal anti-inflammatory (indomethacin), and the gastric ulcer model induced by ethanol/HCl, which allowed us to evaluate the gastroprotective activity of the extracts at a dose of 250 mg/kg. Subsequently, the total lesion area (mm2) and relative lesion area (%) were determined.


RESULTS
The results showed significant gastroprotective activity against the aggressive agents used - ethanol and indomethacin - for all the extracts tested.


CONCLUSIONS
It is assumed that the fruits have bioactive compounds such as antioxidant substances that act on the prostaglandin levels, protecting them from the damage caused by ethanol and indomethacin. These results prompt further studies to isolate and identify the active properties.
Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brasil.
Luciane Angela Nottar
LAN
Nesello
Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brasil.
Adriana
A
Campos
Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brasil.
Roseane Leandra da
RLD
Rosa
Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brasil.
Sérgio Faloni de
SF
Andrade
Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brasil.
Valdir
V
Cechinel
D000818:Animals; D004195:Disease Models, Animal; D000431:Ethanol; D007887:Fabaceae / Q000737:chemistry* / Q000145:classification; D005638:Fruit / Q000737:chemistry* / Q000145:classification; D005753:Gastric Mucosa / Q000187:drug effects; D007213:Indomethacin; D008297:Male; D051379:Mice; D027822:Myrtaceae / Q000737:chemistry* / Q000145:classification; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D010936:Plant Extracts; D020011:Protective Agents; D000431:Ethanol; D007213:Indomethacin