Genetic polymorphisms of 54 mitochondrial DNA SNP loci in Chinese Xibe ethnic minority group.
We analyzed the genetic polymorphisms of 54 mitochondrial DNA (mtDNA) variants in Chinese Xibe ethnic minority group. A total of 137 unrelated healthy volunteers from Chinese Xibe group were the objects of our study. Among the selected loci, there were 51 variable positions including transitions and transversions, and single nucleotide transitions were common (83.93%) versus transversions. These variations defined 64 different mtDNA haplotypes exclusive of (CA)nand 9 bp deletion variation. The haplotype diversity and discrimination power in Xibe population were 0.9800 ± 0.004 and 0.9699, respectively. Besides, we compared Xibe group with 18 other populations and reconstructed a phylogenetic tree using Neighbor-Joining method. The result revealed that Xibe group was a close to Xinjiang Han and Yanbian Korean groups. Our data also indicated that Xibe group has a close relationship with Daur and Ewenki groups, which is reflected by the history that Xibe was influenced by Daur and Ewenki groups during the development of these groups. In conclusion, the variants we studied are polymorphic and could be used as informative genetic markers for forensic and population genetic application.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China.|Clinical Reaserch Center of Shaanxi Province for Dental and Maxillofacial diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China.|Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China.|Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, 710062, P. R. China.
Chun-Mei
CM
Shen
Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China.
Li
L
Hu
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China.|Clinical Reaserch Center of Shaanxi Province for Dental and Maxillofacial diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China.
Chun-Hua
CH
Yang
Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China.
Cai-Yong
CY
Yin
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China.|Clinical Reaserch Center of Shaanxi Province for Dental and Maxillofacial diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China.
Zhi-Dan
ZD
Li
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China.|Clinical Reaserch Center of Shaanxi Province for Dental and Maxillofacial diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China.
Hao-Tian
HT
Meng
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China.|Clinical Reaserch Center of Shaanxi Province for Dental and Maxillofacial diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China.
Yu-Xin
YX
Guo
Department of Biochemistry and Molecular Biology, Basic Medicine College, Xinjiang Medical University, Urumqi, 830011, P. R. China.
Ting
T
Mei
Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China.
Feng
F
Chen
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China.|Clinical Reaserch Center of Shaanxi Province for Dental and Maxillofacial diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, P. R. China.|Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China.
Bo-Feng
BF
Zhu
D000483:Alleles; D002681:China; D004272:DNA, Mitochondrial / Q000235:genetics*; D005006:Ethnicity; D005787:Gene Frequency; D056426:Genetic Loci; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D018895:Microsatellite Repeats; D008913:Minority Groups; D008928:Mitochondria / Q000235:genetics*; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide
D004272:DNA, Mitochondrial