The Association between Dehydroepiandrosterone Sulfate (DHEA-S) and Bone Mineral Density in Korean Men and Women.
BACKGROUND
The relationship between dehydroepiandrosterone sulfate (DHEA-S) and bone mineral density (BMD) is controversial. And findings of most studies that have investigated this relationship are restricted to postmenopausal women. In this study, we investigated the relationship between serum DHEA-S and BMD in both men and women.


METHODS
This cross-sectional study evaluated a total of 294 healthy Korean participants through a medical examination program. And a subgroup of 154 participants was subjected to a longitudinal analysis. We measured BMD by dual energy X-ray absorptiometry and assayed DHEA-S by a chemiluminescent immunoassay.


RESULTS
We evaluated the association between serum DHEA-S concentration and BMD at the femur trochanter after adjusting for cofounders such as age, body mass index, lifestyle factors, serum cortisol level, serum insulin-like growth factor 1 (IGF-1) level, and sex. Through our longitudinal study, we found that the changes in BMD at the total spine, at the femur neck, and at the femur trochanter were all smaller in the ΔDHEA-S <0 group than in the ΔDHEA-S >0 group.


CONCLUSIONS
We found that there was a positive correlation between serum DHEA-S and femur BMD, which suggests that controlling serum DHEA-S levels may retard age-related BMD reduction in Koreans.
Department of Family Medicine, Bundang CHA Medical Center, CHA University School of Medicine, Seoul, Korea.
Seung-Gun
SG
Park
Department of Endocrinology Internal Medicine, Chaum Life Center, CHA University School of Medicine, Seoul, Korea.
Sena
S
Hwang
Anti-aging Center, Chaum Life Center, CHA University School of Medicine, Seoul, Korea.
Jong-Suk
JS
Kim
Department of Family Medicine, Bundang CHA Medical Center, CHA University School of Medicine, Seoul, Korea.
Kyung-Chae
KC
Park
Department of Family Medicine, Bundang CHA Medical Center, CHA University School of Medicine, Seoul, Korea.
Yuri
Y
Kwon
Anti-aging Center, Chaum Life Center, CHA University School of Medicine, Seoul, Korea.
Kyong-Chol
KC
Kim
Aging; Bone density; Dehydroepiandrosterone sulfate; Osteoporosis