Protective effect of dexpanthenol against nephrotoxic effect of amikacin: An experimental study.
BACKGROUND
Amikacin has the largest spectrum among aminoglycosides, its nephrotoxic effect limits its utilization. Our purpose in this study is to review the protective effect of dexpanthenol against the nephrotoxic effect of amikacin, accompanied with histopathological and biochemical parameters.


METHODS
32 rats were randomly separated into four groups with eight in each (amikacin (1.2mg/kg/day), amikacin (1.2mg/kg/day)+dexpanthenol (500mg/kg/day), dexpanthenol (500mg/kg/day) and control). In order to assess the oxidative balance and renal damage between groups, biochemical parameters (total antioxidant capacity (TAS), total oxidant stress (TOS), catalase (CAT), paraoxonase (PON), arylesterase (ARES), urea, and creatinin) were studied from the blood samples. At the end of the 14th day, renal tissues were reviewed blindly by a pathologist.


RESULTS
TOS and oxidative stress index (OSI) values were significantly lower in the group which was administered with dexpanthenol+amikacin compared to the group which only received amikacin (respectively, p=0.001, p=0.002). Antioxidant biochemical parameters (TAS, CAT, PON, and ARES) were significantly higher in the group which was administered with dexpanthenol+amikacin compared to the group administered only with amikacin (respectively, p=0.007, p=0.001, p=0.003, p=0.003). Urea and creatitin values were found to be significantly lower in the group which was administered with dexpanthenol+amikacin compared to the group administered only with amikacin (respectively, p=0.002, p=0.001). Histopathologic changes such as glomerular and tubular epithelium changes and interstitial edema were clearly observed in the group administered only with amikacin, such findings were insignificant in the group administered with dexpanthenol+amikacin.


CONCLUSIONS
It was revealed with biochemical and histopathologic data that nephrotoxic effects created by amikacin administration can be limited with dexpanthenol by using them together, and further advanced clinical studies are required.
Bezmialem Vakif University, Department of Internal Medicine, Fatih, Istanbul, Turkey. Electronic address: dr.elifecedogan@gmail.com.
Elif Ece
EE
Doğan
Bezmialem Vakif University, Department of Nephrology, Fatih, Istanbul, Turkey.
Reha
R
Erkoç
Bezmialem Vakif University, Department of Internal Medicine, Fatih, Istanbul, Turkey.
İskender
İ
Ekinci
Bezmialem Vakif University, Department of Internal Medicine, Fatih, Istanbul, Turkey.
Jamshid
J
Hamdard
Bezmialem Vakif University, Department of Nephrology, Fatih, Istanbul, Turkey.
Barış
B
Döner
Bezmialem Vakif University, Department of Internal Medicine, Fatih, Istanbul, Turkey.
Mehmet Ali
MA
Çıkrıkçıoğlu
Bezmialem Vakif University, Department of Internal Medicine, Fatih, Istanbul, Turkey.
Cumali
C
Karatoprak
Bezmialem Vakif University, Department of Pathology, Fatih, Istanbul, Turkey.
Ganime
G
Çoban
Bezmialem Vakif University, Department of Biochemistry, Fatih, Istanbul, Turkey.
Ömer Faruk
ÖF
Özer
Bezmialem Vakif University, Department of Nephrology, Fatih, Istanbul, Turkey.
Rümeyza
R
Kazancıoğlu
D000583:Amikacin / Q000009:adverse effects*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy / Q000378:metabolism; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007674:Kidney Diseases / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D016877:Oxidants; D020011:Protective Agents; D010205:Pantothenic Acid; C007288:dexpanthenol; D000583:Amikacin
Amikacin; Dexpanthenol; Nephrotoxicity; Oxidative stress