Effects of exercise training on kinin receptors expression in rats with myocardial infarction.
OBJECTIVE
The objective of this study is to determine the role of kinin B1 and B2 receptors in exercise-induced cardiac muscle angiogenesis.


METHODS
Thirty Wistar rats were randomly assigned to the control group, the myocardial infarction group and the exercise training group (myocardial infarction model was made and received 30 min exercise training on a treadmill). After 4 weeks of experiment, cardiac muscle was harvested.


RESULTS
B1 and B2 receptor mRNA and protein levels in the exercise-training group were significantly higher than those in the myocardial infarction group, which were higher than those in the control group. Capillary number in the cardiac muscle also showed the same tendency. There was a correlation between capillary number and B1 receptor protein (not B2 receptor protein) in the all groups.


CONCLUSIONS
Kinin B1 and B2 receptors play roles in exercise-induced cardiac muscle angiogenesis. However, the B1 receptor appears to have a more prominent role.
a Department of Rehabilitation Medicine , Affiliated Zhongshan Hospital of Dalian University , Dalian , China.
Mei
M
Shen
a Department of Rehabilitation Medicine , Affiliated Zhongshan Hospital of Dalian University , Dalian , China.
Min
M
Yu
a Department of Rehabilitation Medicine , Affiliated Zhongshan Hospital of Dalian University , Dalian , China.
Jingya
J
Li
a Department of Rehabilitation Medicine , Affiliated Zhongshan Hospital of Dalian University , Dalian , China.
Li
L
Ma
D000818:Animals; D015153:Blotting, Western; D007124:Immunoenzyme Techniques; D007705:Kinins / Q000378:metabolism*; D008297:Male; D009203:Myocardial Infarction / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D010805:Physical Conditioning, Animal; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D060888:Real-Time Polymerase Chain Reaction; D043783:Receptor, Bradykinin B1 / Q000235:genetics / Q000378:metabolism*; D043782:Receptor, Bradykinin B2 / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D007705:Kinins; D012333:RNA, Messenger; D043783:Receptor, Bradykinin B1; D043782:Receptor, Bradykinin B2
Angiogenesis; exercise training; kinin B1 receptor; kinin B2 receptor; myocardial infarction