A Survival Score for Patients Assigned to Palliative Radiotherapy for Metastatic Bladder Cancer.
To create a survival score for patients with metastatic bladder cancer.



In 46 irradiated patients, six characteristics were evaluated for their association with survival: Age, gender, Karnofsky performance scale, initial stage (American Joint Committee on Cancer), number of metastatic sites, and interval between bladder cancer diagnosis and palliative radiotherapy. Characteristics showing a trend (p<0.15) were incorporated into the score. Six-month survival rates were divided by 10. Patients' scores were derived by totaling the scores of these characteristics.



Performance scale (p=0.14), stage (p=0.055) and number of metastatic sites (p=0.10) showed a trend for association with survival. Patients' scores were 6, 7, 8, 10 or 12 points, with corresponding 6-month survival rates of 20%, 0%, 0%, 46% and 45% (p=0.038). Two groups were created, with 6-8 and with 10-12 points, with 6-month survival rates of 9% and 46% (p=0.002), respectively.



A new survival score was developed. Patients with 6-8 points should receive less aggressive treatments for metastatic bladder cancer. Those with 10-12 points may receive more intensive approaches.
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net.
Dirk
D
Rades
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Lisa
L
Manig
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.|Private Practice of Radiation Oncology, Hannover, Germany.
Stefan
S
Janssen
Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.
Steven E
SE
Schild
D000368:Aged; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D017567:Karnofsky Performance Status; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010166:Palliative Care / Q000379:methods*; D011379:Prognosis; D011878:Radiotherapy / Q000379:methods*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000401:mortality* / Q000532:radiotherapy*
Metastatic bladder cancer; palliation; personalized treatment; radiotherapy; survival score