A proposal for standardized grading of chronic changes in native kidney biopsy specimens.
Chronic changes represent an important component of native kidney biopsy evaluation and have a major bearing on predicting prognosis and guiding treatment. We propose here a uniform, semiquantitative approach to assessing such changes, which include glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis, and we report these findings as an overall chronicity grade.
Sanjeev
S
Sethi
Vivette D
VD
D'Agati
Cynthia C
CC
Nast
Agnes B
AB
Fogo
An S
AS
De Vriese
Glen S
GS
Markowitz
Richard J
RJ
Glassock
Fernando C
FC
Fervenza
Surya V
SV
Seshan
Andrew
A
Rule
Lorraine C
LC
Racusen
Jai
J
Radhakrishnan
Christopher G
CG
Winearls
Gerald B
GB
Appel
Ingeborg M
IM
Bajema
Anthony
A
Chang
Robert B
RB
Colvin
H Terence
HT
Cook
Sundaram
S
Hariharan
Loren P
LP
Herrera Hernandez
Neeraja
N
Kambham
Michael
M
Mengel
Karl A
KA
Nath
Helmut G
HG
Rennke
Pierre
P
Ronco
Brad H
BH
Rovin
Mark
M
Haas
D001706:Biopsy / Q000592:standards*; D018450:Disease Progression; D006801:Humans; D007668:Kidney / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012720:Severity of Illness Index; D009626:Terminology as Topic
arteriosclerosis; glomerulosclerosis; interstitial fibrosis; native kidney biopsy; tubular atrophy