Genetic control of autophagy underlies pathogenesis of inflammatory bowel disease.
Autophagy contributes to cellular homeostasis in the face of nutrient deprivation and other cellular stresses. Cell type-specific functions for autophagy are critical in maintaining homeostasis at both the tissue level and at the whole-organism level. Recent work has highlighted the ways in which human genetic variants modulate autophagy to alter epithelial and immune responses in inflammatory bowel disease.
Broad Institute, Cambridge, Massachusetts, USA.|Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
K G
KG
Lassen
Broad Institute, Cambridge, Massachusetts, USA.|Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.|Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
R J
RJ
Xavier
D000818:Animals; D001343:Autophagy / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics; D004848:Epithelium / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D007109:Immunity / Q000235:genetics; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D009928:Organ Specificity; D011110:Polymorphism, Genetic