Estimation of whole-body radiation exposure from brachytherapy for oral cancer using a Monte Carlo simulation.
Early stage oral cancer can be cured with oral brachytherapy, but whole-body radiation exposure status has not been previously studied. Recently, the International Commission on Radiological Protection Committee (ICRP) recommended the use of ICRP phantoms to estimate radiation exposure from external and internal radiation sources. In this study, we used a Monte Carlo simulation with ICRP phantoms to estimate whole-body exposure from oral brachytherapy. We used a Particle and Heavy Ion Transport code System (PHITS) to model oral brachytherapy with 192Ir hairpins and 198Au grains and to perform a Monte Carlo simulation on the ICRP adult reference computational phantoms. To confirm the simulations, we also computed local dose distributions from these small sources, and compared them with the results from Oncentra manual Low Dose Rate Treatment Planning (mLDR) software which is used in day-to-day clinical practice. We successfully obtained data on absorbed dose for each organ in males and females. Sex-averaged equivalent doses were 0.547 and 0.710 Sv with 192Ir hairpins and 198Au grains, respectively. Simulation with PHITS was reliable when compared with an alternative computational technique using mLDR software. We concluded that the absorbed dose for each organ and whole-body exposure from oral brachytherapy can be estimated with Monte Carlo simulation using PHITS on ICRP reference phantoms. Effective doses for patients with oral cancer were obtained.
Department of Oral and Maxillofacial Radiology, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan.
Y
Y
Ozaki
Department of Oral and Maxillofacial Radiology, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan.
H
H
Watanabe
Department of Oral Radiation Oncology, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan.
A
A
Kaida
Department of Oral Radiation Oncology, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan.
M
M
Miura
Department of Radiation Therapeutics and Oncology, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan.
K
K
Nakagawa
Department of Radiation Therapeutics and Oncology, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan.
K
K
Toda
Department of Radiation Therapeutics and Oncology, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan.
R
R
Yoshimura
Center of Advanced Medicine for Dental and Oral Diseases, National Center for Geriatrics and Gerontology, Moriokacho 7-430, Obu-shi, Aichi, Obu, 474-8511, Japan.
Y
Y
Sumi
Department of Oral and Maxillofacial Radiology, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan.
T
T
Kurabayashi
D001918:Brachytherapy; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006046:Gold / Q000737:chemistry; D020450:Heavy Ions; D006801:Humans; D007495:Iridium / Q000737:chemistry; D008297:Male; D009010:Monte Carlo Method; D009062:Mouth Neoplasms / Q000532:radiotherapy*; D017785:Photons; D014916:Whole-Body Irradiation
D007495:Iridium; D006046:Gold
Monte Carlo simulation; brachytherapy; estimation; exposure; oral cancer