Hypoglycemic effect of hawthorn in type II diabetes mellitus rat model.
BACKGROUND
Hawthorn is a popular herb in many different traditional medicine systems, including traditional Chinese medicine, where it has long been used for the treatment of hyperglycemia. However, most of its varied biological activities remain unexplored. This study investigated the hypoglycemic effect of hawthorn extracts in type II diabetic (T2DM) rat model. A total of 54 rats were randomly divided into six groups: normal control group; type II diabetic model group (T2DM; these rats were induced by high-fat diet and streptozotocin); high, middle and low concentrations of hawthorn treatment (HTH, HTMand HTLT2DM rats were given hawthorn extract at a dose of 50, 100 and 200 mg kg-1body weight, respectively); and positive control group (orlistat 40 mg kg-1body weight).


RESULTS
Triglyceride and total cholesterol serum levels were lower in the hawthorn extract-treated groups than in the T2DM control group (P < 0.01). Furthermore, hawthorn extracts decreased blood glucose level and increased plasma insulin release from pancreas.


CONCLUSIONS
Positive effects of hawthorn against streptozotocin-induced T2DM were demonstrated. This study suggests that hawthorn extract represents a useful agent for the prevention or treatment of T2DM. © 2017 Society of Chemical Industry.
Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development CIC, College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, Shaanxi, China.|College of Veterinary Medicine, Northwest A&F University, Yangling, China.|College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
Aili
A
Aierken
Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development CIC, College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, Shaanxi, China.|Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany.
Tina
T
Buchholz
Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development CIC, College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, Shaanxi, China.
Chen
C
Chen
Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development CIC, College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, Shaanxi, China.|College of Veterinary Medicine, Northwest A&F University, Yangling, China.|College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
Xiaoying
X
Zhang
Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development CIC, College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, Shaanxi, China.|Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany.
Matthias F
MF
Melzig
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D027825:Crataegus / Q000737:chemistry*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D010179:Pancreas / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol
hawthorn (Crataegus pinnatifida Bunge); orlistat; streptozotocin; type II diabetes mellitus