Hypoxia inducible factor one alpha and human viral pathogens.
If the oxygen tension level is 21% in ambient air, it is only between 14% and 1% in vivo. Consequently, viral pathogens are exposed and must adapt to these fluctuating oxygen levels to colonize the host and cause diseases. The problem is that for many years, the virological studies have been performed at 21% oxygen levels and consequently this is a real handicap to have a correct view of the mechanistic aspects of human viral infections. In this brief review, we describe for some selected examples the interactions of human viruses with this relative hypoxia observed in vivo.
Hôpital Saint-Louis, université Paris 7 Paris Diderot, AP-HP, 75010 Paris, France.
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Morinet
Hôpital Ambroise-Paré, université Versailles Saint-Quentin-en-Yvelines, AP-HP, 92100 Boulogne-Billancourt, France.
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Parent
Laboratoire des agents infectieux et hygiène, université de Saint-Étienne, CHU de Saint-Étienne, 42270 Saint-Étienne, France. Electronic address: sylvie.pillet@chu-st-etienne.fr.
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Pillet
LABOCEA R&D, CNRS, 29280 Plouzané, France.
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M
Koken
Hôpital Saint-Louis, université Paris 7 Paris Diderot, AP-HP, 75010 Paris, France.
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Lebbé
Hôpital Ambroise-Paré, université Versailles Saint-Quentin-en-Yvelines, AP-HP, 92100 Boulogne-Billancourt, France.
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Capron
D004266:DNA Virus Infections / Q000235:genetics / Q000473:pathology / Q000821:virology; D004267:DNA Viruses / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000502:physiology*; D012327:RNA Virus Infections / Q000235:genetics / Q000473:pathology; D012328:RNA Viruses / Q000472:pathogenicity / Q000502:physiology; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000472:pathogenicity*
D051795:Hypoxia-Inducible Factor 1, alpha Subunit
AIDS; HIF-1 alpha; Hypoxia; Kaposi sarcoma