Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives.
Transdermal compositions for pain management are comprised of nonsteroidal anti-inflammatory drugs, opioid drugs, and adjuvant drugs acting on: voltage-gated channels, gamma-aminobutyric acid receptors, acute musculoskeletal pain, and as an antidepressant. In this work, baclofen, bupivacaine, cyclobenzaprine, diclofenac, gabapentin, ibuprofen, ketamine, and pentoxifylline were loaded in transdermal compositions, prepared using a mixture of lipids (isopropyl palmitate and mineral oil) and one of two selected penetration enhancer mixtures: alkyl dimethicone, phenyl trimethicone, and polyoxyethylene sorbitan monostearate; and cetostearyl polyoxyethylene ether and ethylene oxide/propylene oxide copolymer. The influence of penetration enhancers on transdermal delivery was evaluated using Franz-type diffusion cells and Normal Human 3D Model of Epidermal Tissue. Results showed that drug delivery is affected by the penetration enhancer used in the transdermal composition.
Humco Compounding Professional Services, Austin, Texas.
John
J
Trimble
Humco Compounding Professional Services, Austin, Texas. blight@humco.com.
Bob
B
Light
D000279:Administration, Cutaneous; D000700:Analgesics / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D010539:Permeability; D012869:Skin Absorption
D000700:Analgesics