Ocular Involvement in Children with Inflammatory Bowel Disease.
Data on ocular manifestations of inflammatory bowel disease (IBD) in children are limited. Some authors have reported a high prevalence of asymptomatic uveitis, yet the significance of these observations is unknown and there are no recommendations on which ophthalmologic follow-up should be offered.



Children with IBD seen at a single referral center for pediatric gastroenterology were offered ophthalmologic evaluation as part of routine care for their disease. Ophthalmologic evaluation included review of ocular history as well as slit-lamp and fundoscopic examination. Medical records were also reviewed for previous ophthalmologic diagnoses or complaints.



Data from 94 children were included (52 boys; median age 13.4 yr). Forty-six patients had a diagnosis of Crohn's disease, 46 ulcerative colitis, and 2 IBD unclassified. Intestinal disease was in clinical remission in 70% of the patients; fecal calprotectin was elevated in 64%. One patient with Crohn's disease had a previous diagnosis of clinically manifest uveitis (overall uveitis prevalence: 1.06%; incidence rate: 0.3 per 100 patient-years). This patient was also the only one who was found to have asymptomatic uveitis at slit-lamp examination. A second patient had posterior subcapsular cataract associated with corticosteroid treatment. No signs of intraocular complications from previous unrecognized uveitis were observed in any patient.



Children with IBD may have asymptomatic uveitis, yet its prevalence seems lower than previously reported, and it was not found in children without a previous diagnosis of clinically manifest uveitis. No ocular complications from prior unrecognized uveitis were observed.
*Department of Medicine, Surgery, and Health Sciences, University of Trieste, Trieste, Italy; and †Institute for Maternal and Child Health IRCCS "Burlo Garofolo," Trieste, Italy.
Samuele
S
Naviglio
Fulvio
F
Parentin
Silvia
S
Nider
Nicolò
N
Rassu
Stefano
S
Martelossi
Alessandro
A
Ventura
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D007558:Italy / Q000453:epidemiology; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D008297:Male; D012074:Remission Induction; D014605:Uveitis / Q000453:epidemiology*
D039841:Leukocyte L1 Antigen Complex