Investigations of octylglyceryl dextran-graft-poly(lactic acid) nanoparticles for peptide delivery to the brain.
Develop modified dextran nanoparticles showing potential to assist with drug permeation across the blood-brain barrier for the delivery of neuropeptides.



Nanoparticles loaded by emulsification with model macromolecular actives were characterized in terms of stability, cytotoxicity and drug-release behavior. Peptide-loaded nanoformulations were tested in an in vivo trout model and in food-deprived mice.



Nanoformulations loaded with model peptides showed good stability and appeared nontoxic in low concentration against human brain endothelial cells. They were found to preserve the bioactivity of loaded peptides (angiotensin II) as demonstrated in vivo using a trout model, and to induce a transient reduction of food consumption in mice when loaded with an anorexigenic octaneuropeptide.



Octylglyceryl dextran-graft-poly(lactic acid) nanoparticles formulated by emulsification demonstrate potential for peptide delivery.
School of Pharmacy & Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, PO1 2DT, UK.
Asme
A
Boussahel
School of Pharmacy & Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, PO1 2DT, UK.
Daniel M
DM
Ibegbu
Laboratory of Neuronal & Neuroendocrine Differentiation & Communication, INSERM U1239, Normandy University, 76000 Rouen, France.
Rhita
R
Lamtahri
Laboratory of Neuronal & Neuroendocrine Differentiation & Communication, INSERM U1239, Normandy University, 76000 Rouen, France.
Julie
J
Maucotel
Laboratory of Neuronal & Neuroendocrine Differentiation & Communication, INSERM U1239, Normandy University, 76000 Rouen, France.
Julien
J
Chuquet
Laboratory of Neuronal & Neuroendocrine Differentiation & Communication, INSERM U1239, Normandy University, 76000 Rouen, France.
Benjamin
B
Lefranc
Laboratory of Neuronal & Neuroendocrine Differentiation & Communication, INSERM U1239, Normandy University, 76000 Rouen, France.
Jérôme
J
Leprince
School of Pharmacy & Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, PO1 2DT, UK.
Marta
M
Roldo
Neurophysiology Laboratory, LaTIM UMR 1101, University of Brest, 29238 Cedex 3, France.
Jean-Claude Le
JL
Mével
School of Pharmacy & Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, PO1 2DT, UK.
Darek
D
Gorecki
School of Pharmacy & Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, PO1 2DT, UK.
Eugen
E
Barbu
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects*; D002460:Cell Line; D003911:Dextrans / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry
D003911:Dextrans; D010455:Peptides; D011091:Polyesters; C033616:poly(lactide)
brain; dextran; drug delivery; nanoparticles; neuropeptides