Primary central nervous system lymphoma: essential points in diagnosis and management.
Primary central nervous system lymphoma (PCNSL) is an extra-nodal non-Hodgkin lymphoma. PCNSL is defined as lymphoma involving the brain, leptomeninges, eyes, or spinal cord without evidence of lymphoma outside the CNS. Treatment includes induction with chemotherapy and consolidation with whole-brain radiotherapy or high-dose chemotherapy supported by autologous stem cell transplantation. High-dose methotrexate is the most important drug in cases with PCNSL, and this drug will be used in combination with small molecules, BTK inhibitors, new monoclonal antibodies, and checkpoint blockers.
Department of Medical Oncology, Faculty of Medicine, Cukurova University, Adana, Turkey. sepay@cu.edu.tr.
Semra
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Paydas
D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000628:therapy*
Chemotherapy; Management; Pathogenesis; Primary central nervous system lymphoma; Prognosis; Radiotherapy