Rational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy.
OBJECTIVE
Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT.


METHODS
The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging.
Cardiology, Rennes University Hospital, INSERM 1414 Clinical Investigation Center, Innovative Technology, 2 Rue Henri Le Guilloux, CHU Pontchaillou, Rennes F-35000, France.|LTSI, Université de Rennes-INSERM, UMR 1099, Rennes, France.
Erwan
E
Donal
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Victoria
V
Delgado
CHU Limoges, Hôpital Dupuytren, Cardiologie, Limoges, France.|INSERM 1094, Faculté de médecine de Limoges, 2, rue Marcland, 87000 Limoges, France.
Julien
J
Magne
Bristol Heart Institute, Bristol NIHR Cardiovascular Biomedical Research Unity, University of Bristol, Bristol, UK.
Chiara
C
Bucciarelli-Ducci
Cardiology, Rennes University Hospital, INSERM 1414 Clinical Investigation Center, Innovative Technology, 2 Rue Henri Le Guilloux, CHU Pontchaillou, Rennes F-35000, France.|LTSI, Université de Rennes-INSERM, UMR 1099, Rennes, France.
Christophe
C
Leclercq
UZ Brussel-CVHZ, ICMI 1090 Brussels, Belgium.
Bernard
B
Cosyns
Cardiovascular Institute, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain.
Marta
M
Sitges
Department of Cardiology, Oslo University Hospital and University of Oslo, Norway.
Thor
T
Edvardsen
Baskent University, Ankara, Turkey.
Elif
E
Sade
Department of Cardiology, University Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Ivan
I
Stankovic
Cardiothoracic Department, San Raffaele University Hospital, IRCCS, 20132 Milan, Italy.
Eustachio
E
Agricola
Department of Advanced Biomeducal Sciences, Federico II University Hospital, Naples, Italy.
Maurizio
M
Galderisi
Department of Cardiology, University of Liège Hospital, GIGA Cardiovascular Sciences, Heart Valve Clinic, CHU SartTilman, Liège, Belgium.|Gruppo Villa Maria Care and Research, Anthea Hospital, Bari, Italy.
Patrizio
P
Lancellotti
LTSI, Université de Rennes-INSERM, UMR 1099, Rennes, France.
Alfredo
A
Hernandez
Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Cardiovascular and Metabolic Medicine University of Leeds, Clarendon Way, Leeds, UK.
Sven
S
Plein
Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua 35128, Italy.
Denisa
D
Muraru
Tel Aviv University Sheba Medical Center, Tel Hashomer, Israel.
Ehud
E
Schwammenthal
Department of Electrophysiology, University of Leipzig-Heart Center, Leipzig, Germany.
Gerhard
G
Hindricks
University of Medicine and Pharmacy "Carol Davila"-Euroecolab, Institute of Cardiovascular Diseases, Bucharest, Romania.
Bogdan A
BA
Popescu
LTSI, Université de Rennes-INSERM, UMR 1099, Rennes, France.|Department of Cardiology, Aix-Marseille Université, 13284 Marseille, France.
Gilbert
G
Habib
D000368:Aged; D057791:Cardiac Imaging Techniques / Q000379:methods; D058406:Cardiac Resynchronization Therapy / Q000379:methods*; D015331:Cohort Studies; D016001:Confidence Intervals; D004452:Echocardiography / Q000379:methods*; D005060:Europe; D005260:Female; D006333:Heart Failure / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D038622:Internationality; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D015996:Survival Rate; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy*; D020257:Ventricular Remodeling / Q000502:physiology
cardiac magnetic resonance ; cardiac resynchronization therapy ; echocardiography ; observational study; strain 