Highly oxygenated antiausterity agents from the leaves of Uvaria dac.
From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I-L (1-4) were isolated together with nine previously reported compounds (5-13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1μM), PSN-1 (PC50, 9.7μM), MIA PaCa-2 (PC50, 29.1μM), Capan-1 (73.0μM) and KLM-1 (25.9μM).
Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: suresh@inm.u-toyama.ac.jp.
Suresh
S
Awale
Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan; Pharmacognosy Department, National Research Centre, 33-El-Bohouth St., Dokki, Giza, Egypt.
Ahmed M
AM
Tawila
Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Dya Fita
DF
Dibwe
Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan.
Jun-Ya
JY
Ueda
Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Sijia
S
Sun
Faculty of Pharmacy, Srinakharinwirot University, Nakhon Nayok 26120, Thailand.
Sirivan
S
Athikomkulchai
Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Chandrashaker
C
Balachandran
Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Ikuo
I
Saiki
Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Kinzo
K
Matsumoto
Research Institute for Biomedical Sciences, Tokyo University of Science, 2669 Yamazaki, Noda, Chiba 278-8510, Japan.
Hiroyasu
H
Esumi
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D053138:Cyclohexenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010100:Oxygen / Q000737:chemistry*; D010179:Pancreas / Q000187:drug effects; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D018515:Plant Leaves / Q000737:chemistry; D031046:Uvaria / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D053138:Cyclohexenes; C052568:cyclohexene; D010100:Oxygen
Antiausterity agents; PANC-1; Pancreatic cancer; Preferential cytotoxicity; Uvaria dac