Intrathecal magnetic drug targeting for localized delivery of therapeutics in the CNS.
The challenge in treating neurological diseases is not lack of drug potency, but ineffective targeting techniques. We propose a technique called intrathecal magnetic drug targeting (IT-MDT), in which intrathecally injected magnetic nanoparticles (MNPs) are targeted to specific sites using external magnets.



MRI and histology confirmed localization of MNPs via IT-MDT at target sites along the spine of Sprague-Dawley rats.



MRI results confirmed greater MNP localization when the duration of magnet application was extended. Histological analysis quantified MNP tissue uptake and provided insight into their route of transport into deeper tissue regions.



IT-MDT has potential for future use in neurological disease treatments. It can produce localized therapeutic effect, with decreased systemic toxicity.
Department of Bioengineering, University of Illinois at Chicago, 851 S. Morgan Street, 218 SEO, Chicago, IL 60607, USA.
Indu
I
Venugopal
Department of Bioengineering, University of Illinois at Chicago, 851 S. Morgan Street, 218 SEO, Chicago, IL 60607, USA.
Nazia
N
Habib
Department of Bioengineering, University of Illinois at Chicago, 851 S. Morgan Street, 218 SEO, Chicago, IL 60607, USA.
Andreas
A
Linninger
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000008:administration & dosage*; D059346:Magnets; D009422:Nervous System Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D051381:Rats
D058185:Magnetite Nanoparticles
intrathecal drug delivery; magnetic drug targeting; magnetic nanoparticles; targeted delivery