Multiple and Recurrent Squamous Cell Carcinoma of the Oral Cavity After Graft-Versus-Host Disease.
Oral squamous cell carcinoma (OSCC) is one of the most common secondary solid tumors in patients who have undergone hematopoietic stem cell transplantation (HSCT). However, according to previous reports, multiple and recurrent OSCC is very rare. The presented case shows the susceptibility to the development of secondary malignancies, particularly oral cancer, of patients who present with chronic graft-versus-host disease after HSCT. OSCC after HSCT appears to be more invasive and has a tendency to recur, with a poor prognosis. Therefore, regular and thorough evaluations of the oral mucosa are recommended for all patients who undergo bone marrow transplantation and have chronic graft-versus-host disease.
Resident, Department of Stomatology, Wuhan Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China.
Xiuhong
X
Weng
Resident, Department of Stomatology, Wuhan Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China.
Yuzhen
Y
Xing
Associated Professor, Department of Stomatology, Wuhan Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China. Electronic address: chengbo_01@hotmail.com.
Bo
B
Cheng
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D018450:Disease Progression; D006086:Graft vs Host Disease / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male; D009062:Mouth Neoplasms / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*