Changes in some biochemical parameters of alloxanized rats administered with varying concentrations of quail egg solution.
Background Quail egg is said to heal all sorts of ailments including diabetes and liver diseases, and people have started taking it indiscriminately without verification and standardization. This study investigated some biochemical effects associated with administration of varying concentrations of quail egg solution to alloxanized rats. Methods Thirty (30) adult male albino Wistar rats were assigned to 5 groups of 6 rats each. Groups 2-5 rats were injected with alloxan monohydrate intraperitoneally at the dose of 160 mg/kg while rats in group 1 served as normal control. Upon establishment of fasting blood glucose level above 126 mg/dL, the rats in groups 2-4 were administered 30, 15, and 7.5 mg/mL of quail egg solution respectively for 7 days. Rats in groups 1 and 5 received distilled water (10 mL/kg) each. All treatments were through the oral route. At the end of 7 days duration of the study, blood samples for some biochemical (alanine aminotransferase [ALT] and blood urea nitrogen [BUN]) analyses were collected. Results Results indicated that the quail egg administration to alloxanized rats especially at the concentration of 30 mg/mL significantly (p<0.5) reduced the elevated levels of ALT and BUN. Conclusions It was concluded that administration of quail egg solution to alloxanized rats mitigated hepatic injury and ameliorated renal lesion that may have resulted from the effect of alloxan monohydrate.
.
Patrick Emeka
PE
Aba
.
Christian Onwuchekwa
CO
Okorie-Kanu
D000496:Alloxan / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000150:complications / Q000628:therapy*; D004531:Eggs; D008297:Male; D011784:Quail; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions; D016896:Treatment Outcome
D015415:Biomarkers; D012996:Solutions; D000496:Alloxan
diabetes; organ damage markers; quail egg