Supply-Side Disruption in Cocaine Production Associated With Cocaine-Related Maternal and Child Health Outcomes in the United States.
To investigate the effects of precursor chemical regulation aimed at reducing cocaine production on cocaine-related maternal and newborn hospital stays in the United States.



We analyzed monthly counts of maternal and neonatal stays from January 2002 through December 2013 by using a quasi-experimental interrupted time series design. We estimated the preregulation linear trend, postregulation change in linear trend, and abrupt change in level.



The number of monthly cocaine-related maternal and neonatal stays decreased by 221 and 128 stays, respectively, following the cocaine precursor regulation change. We also observed a further decline in per-month maternal and neonatal stays of 18 and 8 stays, respectively.



A supply-side disruption in the United States cocaine market was associated with reduced hospital stays for 2 vulnerable populations: pregnant women and newborns. Results support findings that federal precursor regulation can positively reduce cocaine availability in the United States.
Chris Delcher, Yanning Wang, and Mildred Maldonado-Molina are with the Department of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville. Melvin Livingston is with the Department of Biostatistics and Epidemiology, University of North Texas, Fort Worth. Meredith Mowitz is with the Department of Pediatrics, College of Medicine, University of Florida. Bruce A. Goldberger is with the Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida.
Chris
C
Delcher
Chris Delcher, Yanning Wang, and Mildred Maldonado-Molina are with the Department of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville. Melvin Livingston is with the Department of Biostatistics and Epidemiology, University of North Texas, Fort Worth. Meredith Mowitz is with the Department of Pediatrics, College of Medicine, University of Florida. Bruce A. Goldberger is with the Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida.
Melvin
M
Livingston
Chris Delcher, Yanning Wang, and Mildred Maldonado-Molina are with the Department of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville. Melvin Livingston is with the Department of Biostatistics and Epidemiology, University of North Texas, Fort Worth. Meredith Mowitz is with the Department of Pediatrics, College of Medicine, University of Florida. Bruce A. Goldberger is with the Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida.
Yanning
Y
Wang
Chris Delcher, Yanning Wang, and Mildred Maldonado-Molina are with the Department of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville. Melvin Livingston is with the Department of Biostatistics and Epidemiology, University of North Texas, Fort Worth. Meredith Mowitz is with the Department of Pediatrics, College of Medicine, University of Florida. Bruce A. Goldberger is with the Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida.
Meredith
M
Mowitz
Chris Delcher, Yanning Wang, and Mildred Maldonado-Molina are with the Department of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville. Melvin Livingston is with the Department of Biostatistics and Epidemiology, University of North Texas, Fort Worth. Meredith Mowitz is with the Department of Pediatrics, College of Medicine, University of Florida. Bruce A. Goldberger is with the Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida.
Mildred
M
Maldonado-Molina
Chris Delcher, Yanning Wang, and Mildred Maldonado-Molina are with the Department of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville. Melvin Livingston is with the Department of Biostatistics and Epidemiology, University of North Texas, Fort Worth. Meredith Mowitz is with the Department of Pediatrics, College of Medicine, University of Florida. Bruce A. Goldberger is with the Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida.
Bruce A
BA
Goldberger
D000328:Adult; D000067576:Child Health; D003042:Cocaine / Q000600:supply & distribution*; D019970:Cocaine-Related Disorders / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007902:Length of Stay / Q000331:legislation & jurisprudence* / Q000706:statistics & numerical data*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000517:prevention & control*; D014481:United States / Q000453:epidemiology
D003042:Cocaine