Antimicrobial resistance (AMR) and plant-derived antimicrobials (PDAms) as an alternative drug line to control infections.
Infectious diseases caused by antimicrobial-resistant microbes (ARMs) and the treatment are the serious problems in the field of medical science today world over. The development of alternative drug line to treat such infectious diseases is urgently required. Researches on ARMs revealed the presence of membrane proteins responsible for effusing the antibiotics from the bacterial cells. Such proteins have successfully been treated by plant-derived antimicrobials (PDAms) synergistically along with the commercially available antibiotics. Such synergistic action usually inhibits the efflux pump. The enhanced activity of plant-derived antimicrobials is being researched and is considered as the future treatment strategy to cure the incurable infections. The present paper reviews the advancement made in the researches on antimicrobial resistance along with the discovery and the development of more active PDAms.
Department of Applied Sciences, Faculty of Environmental Science, Himalayan Institute of Technology and Management, BKT, NH 24, Lucknow, 227005, UP, India. jks_345@rediffmail.com.
Jatin
J
Srivastava
Department of Medicinal and Aromatic Plants, School of Agriculture and Allied Sciences, High Altitude Plant Physiology Research Center, H.N.B. Garhwal University, Srinagar, Uttrakhand, India.
Harish
H
Chandra
Department of Medicinal and Aromatic Plants, School of Agriculture and Allied Sciences, High Altitude Plant Physiology Research Center, H.N.B. Garhwal University, Srinagar, Uttrakhand, India.
Anant R
AR
Nautiyal
Department of Chemistry, Dayanand Anglo Vedic College, Civil Lines, Kanpur, UP, India.
Swinder J S
SJ
Kalra
Antimicrobial resistance; Antimicrobial-resistant microbes; Efflux pumps; Plant antimicrobial compounds