Synthesis of novel C-9 carbon substituted derivatives of artemisinin.
Several artemisinin derivatives carrying several groups (alkyl, hydroxyalkyl, allyl or azide) at position 9 have been synthesized starting from artemisinin via enolate formation and subsequent reaction with appropriate electrophiles.
Institute for Organic Chemistry, University of Leipzig, Johannisallee 29, D-04103 Leipzig, Germany.
Daniel
D
Meyer
Institute for Organic Chemistry, University of Leipzig, Johannisallee 29, D-04103 Leipzig, Germany.
Toni
T
Smeilus
Institute for Organic Chemistry, University of Leipzig, Johannisallee 29, D-04103 Leipzig, Germany.
Dimanthi
D
Pliatsika
Institute for Organic Chemistry, University of Leipzig, Johannisallee 29, D-04103 Leipzig, Germany.
Farnoush
F
Mousavizadeh
Institute for Organic Chemistry, University of Leipzig, Johannisallee 29, D-04103 Leipzig, Germany. Electronic address: giannis@uni-leipzig.de.
Athanassios
A
Giannis
D000447:Aldehydes / Q000737:chemistry; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D013237:Stereoisomerism
D000447:Aldehydes; D000962:Antimalarials; D037621:Artemisinins; D002244:Carbon
Anticancer; Antimalarial; Artemisinin