Extremely thermophilic energy metabolisms: biotechnological prospects.
New strategies for metabolic engineering of extremely thermophilic microorganisms to produce bio-based fuels and chemicals could leverage pathways and physiological features resident in extreme thermophiles for improved outcomes. Furthermore, very recent advances in genetic tools for these microorganisms make it possible for them to serve as metabolic engineering hosts. Beyond providing a higher temperature alternative to mesophilic platforms, exploitation of strategic metabolic characteristics of high temperature microorganisms grants new opportunities for biotechnological products. This review considers recent developments in extreme thermophile biology as they relate to new horizons for energy biotechnology.
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905, United States.
Christopher T
CT
Straub
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905, United States.
Benjamin M
BM
Zeldes
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 300602, United States.
Gerrit J
GJ
Schut
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 300602, United States.
Michael Ww
MW
Adams
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905, United States. Electronic address: rmkelly@ncsu.edu.
Robert M
RM
Kelly
D001105:Archaea / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D002245:Carbon Dioxide / Q000378:metabolism; D052837:Chemoautotrophic Growth; D004734:Energy Metabolism; D006358:Hot Temperature; D008031:Lignin / Q000378:metabolism; D060847:Metabolic Engineering
C036909:lignocellulose; D002245:Carbon Dioxide; D008031:Lignin