Rapid diagnosis of tuberculosis. Detection of drug resistance mechanisms.
Tuberculosis is still a serious public health problem, with 10.8 million new cases and 1.8 million deaths worldwide in 2015. The diversity among members of the Mycobacterium tuberculosis complex, the causal agent of tuberculosis, is conducive to the design of different methods for rapid diagnosis. Mutations in the genes involved in resistance mechanisms enable the bacteria to elude the treatment. We have reviewed the methods for the rapid diagnosis of M. tuberculosis complex and the detection of susceptibility to drugs, both of which are necessary to prevent the onset of new resistance and to establish early, appropriate treatment.
Servicio de Microbiología, Hospital Universitario Miguel Servet, Zaragoza, España.
Jesús
J
Viñuelas-Bayón
Servicio de Microbiología, Hospital Universitario Lozano Blesa, CIBERES, Zaragoza, España.
María Asunción
MA
Vitoria
Instituto Aragonés de Ciencias de la Salud, IIS Aragón, CIBERES, Zaragoza, España. Electronic address: ssamper.iacs@aragon.es.
Sofía
S
Samper
D000995:Antitubercular Agents / Q000494:pharmacology; D001431:Bacteriological Techniques; D004352:Drug Resistance, Microbial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D006801:Humans; D025202:Molecular Diagnostic Techniques; D009161:Mycobacterium / Q000145:classification / Q000235:genetics; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D010802:Phylogeny; D011933:Reagent Kits, Diagnostic; D013997:Time Factors; D014376:Tuberculosis / Q000175:diagnosis* / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000235:genetics / Q000382:microbiology
D000995:Antitubercular Agents; D011933:Reagent Kits, Diagnostic
Extensively drug-resistance; Multidrug-resistance; Multirresistencia; Mycobacterium tuberculosis complex; Resistencia extensa o extrema