Nickel-Catalyzed Reduction of Secondary and Tertiary Amides.
The nickel-catalyzed reduction of secondary and tertiary amides to give amine products is reported. The transformation is tolerant of extensive variation with respect to the amide substrate, proceeds in the presence of esters and epimerizable stereocenters, and can be used to achieve the reduction of lactams. Moreover, this methodology provides a simple tactic for accessing medicinally relevant α-deuterated amines.
Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095-1569, United States.
Bryan J
BJ
Simmons
Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095-1569, United States.
Marie
M
Hoffmann
Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095-1569, United States.
Jaeyeon
J
Hwang
Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095-1569, United States.
Moritz K
MK
Jackl
Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095-1569, United States.
Neil K
0000-0002-7793-2629
NK
Garg
D000577:Amides / Q000737:chemistry*; D000588:Amines; D002384:Catalysis; D015394:Molecular Structure; D009532:Nickel
D000577:Amides; D000588:Amines; D009532:Nickel