Primary cutaneous anaplastic large cell lymphoma.
Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a CD30+ lymphoproliferative disorder (LPD) of the skin with a relatively good prognosis in the absence of high-stage disease. CD30+ LPDs comprise approximately 25%-30% of primary cutaneous lymphomas and as a group represent the second most common clonal T-cell neoplasm of the skin behind mycosis fungoides. Diagnosis of PC-ALCL relies strongly on clinicopathologic correlation given the potential morphologic, clinical and molecular overlap with the other cutaneous CD30+ LPD, lymphomatoid papulosis, and more aggressive hematolymphoid neoplasms.
Department of Pathology, Stanford University School of Medicine, Stanford, California.
Ryanne A
RA
Brown
Department of Pathology, Stanford University School of Medicine, Stanford, California.
Sebastian
S
Fernandez-Pol
Department of Pathology, Stanford University School of Medicine, Stanford, California.|Department of Dermatology, Stanford University School of Medicine, Stanford, California.
Jinah
http://orcid.org/0000-0002-5065-5916
J
Kim
D000818:Animals; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology
D017730:Ki-1 Antigen; D009363:Neoplasm Proteins

CD30+ lymphoproliferative disorder; primary cutaneous anaplastic large cell lymphoma