Serum Amyloid A Production Is Triggered by Sleep Deprivation in Mice and Humans: Is That the Link between Sleep Loss and Associated Comorbidities?
Serum amyloid A (SAA) was recently associated with metabolic endotoxemia, obesity and insulin resistance. Concurrently, insufficient sleep adversely affects metabolic health and is an independent predisposing factor for obesity and insulin resistance. In this study we investigated whether sleep loss modulates SAA production. The serum SAA concentration increased in C57BL/6 mice subjected to sleep restriction (SR) for 15 days or to paradoxical sleep deprivation (PSD) for 72 h. Sleep restriction also induced the upregulation ofSaa1.1/Saa2.1mRNA levels in the liver andSaa3mRNA levels in adipose tissue. SAA levels returned to the basal range after 24 h in paradoxical sleep rebound (PSR). Metabolic endotoxemia was also a finding in SR. Increased plasma levels of SAA were also observed in healthy human volunteers subjected to two nights of total sleep deprivation (Total SD), returning to basal levels after one night of recovery. The observed increase in SAA levels may be part of the initial biochemical alterations caused by sleep deprivation, with potential to drive deleterious conditions such as metabolic endotoxemia and weight gain.
Departamento de Análises Clínicas e Toxicológicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, 580, São Paulo SP 05509-000, Brazil. edson.fbq@gmail.com.
Edson M
EM
de Oliveira
Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925, São Paulo SP 04024-002, Brazil. brunavisniauskas@gmail.com.
Bruna
B
Visniauskas
Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925, São Paulo SP 04024-002, Brazil. sergio.tufik@unifesp.br.
Sergio
S
Tufik
Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925, São Paulo SP 04024-002, Brazil. ml.andersen12@gmail.com.
Monica L
ML
Andersen
Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925, São Paulo SP 04024-002, Brazil. jchagas1@gmail.com.
Jair R
JR
Chagas
Departamento de Análises Clínicas e Toxicológicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, 580, São Paulo SP 05509-000, Brazil. anacampa@usp.br.
Ana
A
Campa
D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001835:Body Weight; D015897:Comorbidity; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000097:blood*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000685:Serum Amyloid A Protein / Q000235:genetics / Q000378:metabolism*; D012892:Sleep Deprivation / Q000097:blood*; D015854:Up-Regulation; D015430:Weight Gain; D055815:Young Adult
D015415:Biomarkers; D012333:RNA, Messenger; D000685:Serum Amyloid A Protein
SAA; obesity; sleep curtailment; sleep loss; type 2 diabetes