Reversible crystal-to-crystal chiral resolution: making/breaking non-bonding SO interactions.
An achiral organic molecule adopts a chiral conformation, crystallizing in two morphologies: a racemic form, stable <70 °C, and a homochiral form, stable ≥70 °C. Upon seeding, crystal-to-crystal phase transitions occur reversibly between the racemic and chiral forms. Liquid-to-solid chiral crystallization is observed >90% of the time from the melt.
Department of Chemistry, University of Guelph, Guelph, ON N1G 2W1, Canada. kpreuss@uoguelph.ca.
R Alex
RA
Mayo
Department of Chemistry, University of Guelph, Guelph, ON N1G 2W1, Canada. kpreuss@uoguelph.ca.
David J
DJ
Sullivan
Department of Chemistry, University of Guelph, Guelph, ON N1G 2W1, Canada. kpreuss@uoguelph.ca.
Travis A P
TA
Fillion
Department of Physics, University of Guelph, Guelph, ON N1G 2W1, Canada.
Stefan W
SW
Kycia
Department of Chemistry, University of Guelph, Guelph, ON N1G 2W1, Canada. kpreuss@uoguelph.ca.
Dmitriy V
DV
Soldatov
Department of Chemistry, University of Guelph, Guelph, ON N1G 2W1, Canada. kpreuss@uoguelph.ca.
Kathryn E
http://orcid.org/0000-0003-2342-5346
KE
Preuss