Incidence and prevalence of systemic sclerosis in Campo Grande, State of Mato Grosso do Sul, Brazil.
BACKGROUND
Systemic sclerosis is an autoimmune disease which shows extreme heterogeneity in its clinical presentation and that follows a variable and unpredictable course. Although some discrepancies in the incidence and prevalence rates between geographical regions may reflect methodological differences in the definition and verification of cases, they may also reflect true local differences.


OBJECTIVE
To determine the prevalence and incidence of systemic sclerosis in the city of Campo Grande, state capital of Mato Grosso do Sul (MS), Brazil, during the period from January to December 2014.


METHODS
All health care services of the city of Campo Grande - MS with attending in the specialty of Rheumatology were invited to participate in the study through a standardized form of clinical and socio-demographic assessment. Physicians of any specialty could report a suspected case of systemic sclerosis, but necessarily the definitive diagnosis should be established by a rheumatologist, in order to warrant the standardization of diagnostic criteria and exclusion of other diseases resembling systemic sclerosis. At the end of the study, 15 rheumatologists reported that they attended patients with systemic sclerosis and sent the completed forms containing epidemiological data of patients.


RESULTS
The incidence rate of systemic sclerosis in Campo Grande for the year 2014 was 11.9 per million inhabitants and the prevalence rate was 105.6 per million inhabitants. Systemic sclerosis patients were mostly women, white, with a mean age of 50.58 years, showing the limited form of the disease with a mean duration of the disease of 8.19 years. Regarding laboratory tests, 94.4% were positive for antinuclear antibody, 41.6% for anti-centromere antibody and 19.1% for anti-Scl70; anti-RNA Polymerase III was performed in 37 patients, with 16.2% positive.


CONCLUSIONS
The city of Campo Grande, the state capital of MS, presented a lower incidence/prevalence of systemic sclerosis in comparison with those numbers found in US studies and close to European studies' data.
Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil; Hospital Regional de Mato Grosso do Sul, Serviço de Reumatologia, Campo Grande, MS, Brazil; Universidade Federal de Mato Grosso do Sul (UFMS), Hospital Universitário, Serviço de Reumatologia, Campo Grande, MS, Brazil. Electronic address: clinicaactivite@gmail.com.
Alex Magno Coelho
AMC
Horimoto
Universidade Federal de Mato Grosso do Sul (UFMS), Hospital Universitário, Serviço de Reumatologia, Campo Grande, MS, Brazil; Universidade de Brasília (UnB), Brasília, DF, Brazil; Prefeitura Municipal de Campo Grande, Ambulatório de Especialidades Médicas, Campo Grande, MS, Brazil.
Erica Naomi Naka
ENN
Matos
Universidade Federal de Mato Grosso do Sul (UFMS), Hospital Universitário, Serviço de Reumatologia, Campo Grande, MS, Brazil.
Márcio Reis da
MRD
Costa
Prefeitura Municipal de Campo Grande, Ambulatório de Especialidades Médicas, Campo Grande, MS, Brazil; Universidade Anhanguera (Uniderp), Faculdade de Medicina, Ambulatório de Especialidades Médicas, Campo Grande, MS, Brazil.
Fernanda
F
Takahashi
Santa Casa de Campo Grande, Serviço de Reumatologia, Campo Grande, MS, Brazil.
Marcelo Cruz
MC
Rezende
Caixa de Assistência aos Servidores do Mato Grosso do Sul (CASSEMS), Ambulatório de Especialidades Médicas, Coxim, MS, Brazil.
Letícia Barrios
LB
Kanomata
Prefeitura Municipal de Campo Grande, Ambulatório de Especialidades Médicas, Campo Grande, MS, Brazil.
Elisangela Possebon Pradebon
EPP
Locatelli
Universidade Federal de Mato Grosso do Sul (UFMS), Hospital Universitário, Serviço de Reumatologia, Campo Grande, MS, Brazil; Prefeitura Municipal de Campo Grande, Ambulatório de Especialidades Médicas, Campo Grande, MS, Brazil.
Leandro Tavares
LT
Finotti
Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.
Flávia Kamy Maciel
FKM
Maegawa
Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Rosa Maria Ribeiro
RMR
Rondon
Universidade Federal de Mato Grosso do Sul (UFMS), Hospital Universitário, Serviço de Reumatologia, Campo Grande, MS, Brazil; Universidade Anhanguera (Uniderp), Faculdade de Medicina, Ambulatório de Especialidades Médicas, Campo Grande, MS, Brazil; Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Natália Pereira
NP
Machado
Universidade Anhanguera (Uniderp), Faculdade de Medicina, Ambulatório de Especialidades Médicas, Campo Grande, MS, Brazil.
Flávia Midori Arakaki Ayres Tavares do
FMAATD
Couto
Hospital Regional de Mato Grosso do Sul, Serviço de Reumatologia, Campo Grande, MS, Brazil.
Túlia Peixoto Alves de
TPA
Figueiredo
Universidade Federal da Grande Dourados (UFGD), Hospital Universitário, Serviço de Reumatologia, Dourados, MS, Brazil.
Raphael Antonio
RA
Ovidio
Universidade Federal de Mato Grosso do Sul (UFMS), Hospital Universitário, Serviço de Reumatologia, Campo Grande, MS, Brazil; Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Izaias Pereira da
IPD
Costa
D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D000072140:Rheumatologists / Q000706:statistics & numerical data; D012595:Scleroderma, Systemic / Q000453:epidemiology* / Q000628:therapy; D017678:Sex Distribution
Brasil; Brazil; Esclerodermia; Esclerose sistêmica; Incidence; Incidência; Prevalence; Prevalência; Scleroderma; Systemic sclerosis