Pterostilbene, a dimethylated analog of resveratrol, promotes energy metabolism in obese rats.
Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a dimethylated analog of resveratrol and has been reported to exert various pharmacological effects. In this study, we evaluated the effect of pterostilbene on the pathogenesis of obesity and energy metabolism in obese rats. Pterostilbene significantly activates silent mating type information regulation 2 homolog-1 and peroxisome proliferator-activated receptor-alpha in vitro. At 4 weeks a 0.5% pterostilbene diet markedly suppressed the abdominal white adipose tissue (WAT) accumulation in obese rats. The oxygen consumption and energy expenditure were significantly higher in the pterostilbene group, and pterostilbene increased the fat metabolism rather than the carbohydrate metabolism in obese rats. The mRNA level of uncoupling protein, a thermogenic regulator, was increased and the mRNA levels of fatty acid synthase and leptin, which are involved in lipogenesis and fat storage, were markedly decreased in WAT after the pterostilbene feeding. These results suggest that pterostilbene prevents WAT accumulation through the enhancement of energy metabolism and partly the suppression of lipogenesis in obese OLETF rats.
Department of Applied Biochemistry and Food Science, Saga University, Saga 840-8502, Japan; The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima 890-0065, Japan. Electronic address: knagao@cc.saga-u.ac.jp.
Koji
K
Nagao
Department of Applied Biochemistry and Food Science, Saga University, Saga 840-8502, Japan.
Tomoyuki
T
Jinnouchi
Department of Applied Biochemistry and Food Science, Saga University, Saga 840-8502, Japan.
Shunichi
S
Kai
Department of Health and Nutrition Sciences, Nishikyushu University, Kanzaki 842-8585, Japan.
Teruyoshi
T
Yanagita
D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D009765:Obesity / Q000178:diet therapy / Q000378:metabolism*; D047493:PPAR alpha / Q000378:metabolism; D051381:Rats; D056564:Sirtuin 1 / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology*
D047493:PPAR alpha; D013267:Stilbenes; C107773:pterostilbene; C488368:Sirt1 protein, rat; D056564:Sirtuin 1
Energy expenditure; Obesity; PPARα; Pterostilbene; SIRT1