Epstein-Barr Virus-associated Lymphoproliferative Disorder with Encephalitis Following Anti-thymocyte Globulin for Aplastic Anemia Resolved with Rituximab Therapy: A Case Report and Literature Review.
Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs) sometimes occur following Anti-thymocyte globulin (ATG) administration for allogenic stem cell transplantation but are rare in aplastic anemia (AA) patients. A 55-year-old woman with AA following ATG developed refractory fever and was diagnosed with EBV-LPD. She was successfully treated with weekly rituximab monotherapy; however, she developed EBV encephalitis. She was admitted to the intensive care unit and finally recovered from unconsciousness. EBV-LPD should be considered after ATG for AA when symptoms appear. Because EBV-LPD following ATG for AA can rapidly progress, weekly monitoring of EBV-DNA and early intervention may be necessary.
Department of Oncology and Hematology, The Jikei University School of Medicine, Japan.
Kiyomi
K
Mashima
Shingo
S
Yano
Hiroki
H
Yokoyama
Takeshi
T
Saito
Tomohito
T
Machishima
Takaki
T
Shimada
Yuichi
Y
Yahagi
Shinobu
S
Takahara
Katsuki
K
Sugiyama
Yoji
Y
Ogasawara
Jiro
J
Minami
Yutaro
Y
Kamiyama
Atsushi
A
Katsube
Kazuhito
K
Suzuki
Sayaka
S
Ohshima
Hisashi
H
Yamada
Noriko
N
Usui
Keisuke
K
Aiba
D000741:Anemia, Aplastic / Q000188:drug therapy*; D000961:Antilymphocyte Serum / Q000009:adverse effects* / Q000627:therapeutic use; D004660:Encephalitis / Q000209:etiology*; D020031:Epstein-Barr Virus Infections / Q000209:etiology*; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology*; D008875:Middle Aged
D000961:Antilymphocyte Serum