Manganese(I)-Catalyzed Dispersion-Enabled C-H/C-C Activation.
C-H/C-C Functionalizations were achieved with the aid of a versatile manganese(I) catalyst. Thus, an organometallic manganese-catalyzed C-H activation set the stage for silver-free C-H/C-C transformations with ample substrate scope and excellent levels of chemo-, site-, and diastereo-selectivities. The robust nature of the manganese(I) catalysis regime was reflected by the first C-H/C-C functionalization on amino acids under racemization-free reaction conditions. Detailed experimental and computational mechanistic studies provided strong evidence for a facile C-H activation and a rate-determining C-C cleavage, with considerable contribution from London dispersion interactions.
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Gottingen, Germany.
Tjark H
TH
Meyer
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Gottingen, Germany.
Weiping
W
Liu
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Gottingen, Germany.
Milica
M
Feldt
Institut für Physikalische Chemie, Georg-August-Universität Göttingen, Tammannstraße 6, 37077, Gottingen, Germany.
Axel
A
Wuttke
Institut für Physikalische Chemie, Georg-August-Universität Göttingen, Tammannstraße 6, 37077, Gottingen, Germany.
Ricardo A
http://orcid.org/0000-0002-2720-3364
RA
Mata
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Gottingen, Germany.
Lutz
http://orcid.org/0000-0001-7034-8772
L
Ackermann
C−C cleavage; C−H activation; amino acids; heteroarenes; manganese