Exercise and the Skeletal Muscle Epigenome.
An acute bout of exercise is sufficient to induce changes in skeletal muscle gene expression that are ultimately responsible for the adaptive responses to exercise. Although much research has described the intracellular signaling responses to exercise that are linked to transcriptional regulation, the epigenetic mechanisms involved are only just emerging. This review will provide an overview of epigenetic mechanisms and what is known in the context of exercise. Additionally, we will explore potential interactions between metabolism during exercise and epigenetic regulation, which serves as a framework for potential areas for future research. Finally, we will consider emerging opportunities to pharmacologically manipulate epigenetic regulators and mechanisms to induce aspects of the skeletal muscle exercise adaptive response for therapeutic intervention in various disease states.
Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria 3216, Australia.
Sean L
SL
McGee
Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria 3216, Australia.
Ken R
KR
Walder
D019175:DNA Methylation; D044127:Epigenesis, Genetic; D015444:Exercise / Q000502:physiology*; D005786:Gene Expression Regulation; D042421:Histone Code; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology*; D015398:Signal Transduction