The role of the irreversible electroporation in the hepato-pancreatico-biliary surgery.
Irreversible electroporation is a novel technique growing in popularity over the last years among the ablative modalities. Its unique action mechanism produces irreversible nanopores in the membrane of the cell leading to apoptosis; therefore irreversible electroporation can be used to ablate substantial volumes of tissue without the undesirable thermal effects as the "heat sink effect". Moreover the extracellular matrix is left unperturbed, thus sparing the structural architecture of surrounding structures such as bile ducts and blood vessels. In the last years its use has been widespread in both liver and pancreatic ablation. Irreversible electroporation has shown its safety with however some caution, feasibility and favorable outcomes in clinical settings such as unresectable locally advanced disease in which the surgical and therapeutic options are very limited.
Departmento de cirugía y transplante, Hospital universitario de Zürich, Zúrich, Suiza.
Patricia
P
Sánchez-Velázquez
Departmento de cirugía y transplante, Hospital universitario de Zürich, Zúrich, Suiza. Electronic address: clavien@access.uzh.ch.
Pierre-Alain
PA
Clavien
D001661:Biliary Tract Neoplasms / Q000601:surgery; D001662:Biliary Tract Surgical Procedures / Q000379:methods*; D018274:Electroporation; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery; D010180:Pancreatectomy / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000601:surgery
Ablación hepática; Electroporación Irreversible electroporation; Electroporación irreversible; Hepatic ablation; IRE