An ultrasonically powered implantable device for targeted drug delivery.
A wirelessly powered implantable device is proposed for fully programmable and localized drug delivery. The implant is powered using an external ultrasonic transmitter and operates at <; 5% of the FDA diagnostic ultrasound intensity limit. Drug release is achieved through electrical stimulation of drug-loaded polypyrrole nanoparticles. A design methodology for the implant electronics is presented and experimentally demonstrated to be accurate in predicting the concentration of the released drug. To the best of our knowledge, this is the first ultrasonically powered implantable device platform for targeted drug delivery using electroresponsive polymers. The active area of the implant electronics is just 3 mm × 5 mm.
Jayant
J
Charthad
Spyridon
S
Baltsavias
Devleena
D
Samanta
Ting Chia Chang
Marcus J
MJ
Weber
Niloufar
N
Hosseini-Nassab
Richard N
RN
Zare
Amin
A
Arbabian
D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D004581:Electronics; D053758:Nanoparticles; D019736:Prostheses and Implants; D014465:Ultrasonics / Q000295:instrumentation* / Q000379:methods