Phakellistatins: An Underwater Unsolved Puzzle.
A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1-19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility.
Department of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132-84081 Fisciano (SA), Italy. alemeli87@gmail.com.
Alessandra
A
Meli
Department of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132-84081 Fisciano (SA), Italy. ctedesco@unisa.it.
Consiglia
C
Tedesco
Department of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132-84081 Fisciano (SA), Italy. gdsala@unisa.it.
Giorgio
G
Della Sala
Department of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132-84081 Fisciano (SA), Italy. rschettini@unisa.it.
Rosaria
R
Schettini
Department of Organic Chemistry and CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain. albericio@ub.edu.|School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, South Africa. albericio@ub.edu.
Fernando
F
Albericio
Department of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132-84081 Fisciano (SA), Italy. dericca@unisa.it.
Francesco
F
De Riccardis
Department of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132-84081 Fisciano (SA), Italy. iizzo@unisa.it.
Irene
I
Izzo
D059001:Aquatic Organisms / Q000737:chemistry; D006801:Humans; D010456:Peptides, Cyclic / Q000737:chemistry*; D011392:Proline / Q000737:chemistry; D015203:Reproducibility of Results
D010456:Peptides, Cyclic; C080583:phakellistatin 1; D011392:Proline
marine sponge; peptide synthesis; pharmacological activity; proline-rich cyclopeptide