Anti-G with concomitant anti-C and anti-D: A case report in a pregnant woman.
The G antigen of Rh blood group system is present in almost all D-positive or C-positive red cells but absent from red cells lacking D and C antigens. The differentiation of anti-D and anti-C from anti-G is not necessary for routine transfusion; however, during pregnancy, it is important because anti-G can masquerade as anti-D and anti-C with initial antibody testing. The false presence of anti-D will exclude the patient from receiving anti-D immunoglobulin (RhIG) when the patient actually is a candidate for RhIG prophylaxis. Moreover, patients with positive anti-D or anti-G are at risk of developing hemolytic disease of the fetus and newborn and need close monitoring. Thus, proper identification allows the clinicians to manage patients properly. This case report highlights a rare case of anti-G together with anti-D and anti-C in a pregnant woman. This report disseminates knowledge on identification of anti-G and its importance in pregnant women.
Department of Pathology, Blood Bank Unit, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.
Rabeya
R
Yousuf
Department of Pathology, Blood Bank Unit, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.
Ahmad Nasirudin
AN
Mustafa
Department of Pathology, Blood Bank Unit, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.
Siew-Ling
SL
Ho
Department of Pathology, Blood Bank Unit, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.
Yee-Loong
YL
Tang
Department of Pathology, Blood Bank Unit, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.
Chooi-Fun
CF
Leong
Antenatal antibody; anti-C; anti-D immunoglobulin; anti-G; hemolytic disease of the fetus and newborn