Seven LncRNA-mRNA based risk score predicts the survival of head and neck squamous cell carcinoma.
Dysregulation of mRNAs and long non-coding RNAs (lncRNAs) is one of the most important features of carcinogenesis and cancer development. However, studies integrating the expression of mRNAs and lncRNAs to predict the survival of head and neck squamous cell carcinoma (HNSC) are still limited, hitherto. In current work, we identified survival related mRNAs and lncRNAs in three datasets (TCGA dataset, E-TABM-302, GSE41613). By random forest, seven gene signatures (six mRNAs and lncRNA) were further selected to develop the risk score model. The risk score was significantly associated with survival in both training and testing datasets (E-TABM-302, GSE41613, and E-MTAB-1324). Furthermore, correlation analyses showed that the risk score is independent from clinicopathological features. According to Cox multivariable hazard model and nomogram, the risk score contributes the most to survival than the other clinical information, including gender, age, histologic grade, and alcohol taking. The Gene Set Enrichment Analysis (GSEA) indicates that the risk score is associated with cancer related pathways. In summary, the lncRNA-mRNA based risk score model we developed successfully predicts the survival of 755 HNSC samples in five datasets and two platforms. It is independent from clinical information and performs better than clinical information for prognosis.
Department of otorhinolaryngology,the first affiliated hospital, Zhejiang University School of medicine, 310003, Qingchun Road 79, Hangzhou city, Zhejiang province, China. zhangzhili_zju@126.com.
Zhi-Li
ZL
Zhang
Department of otorhinolaryngology, the second affiliated hospital, Zhejiang University school of medicine, 310003, Qingchun Road 79, Hangzhou city, Zhejiang province, China.
Li-Jing
LJ
Zhao
Department of otorhinolaryngology,the first affiliated hospital, Zhejiang University School of medicine, 310003, Qingchun Road 79, Hangzhou city, Zhejiang province, China.
Liang
L
Chai
Department of otorhinolaryngology,the first affiliated hospital, Zhejiang University School of medicine, 310003, Qingchun Road 79, Hangzhou city, Zhejiang province, China.
Shui-Hong
SH
Zhou
Department of otorhinolaryngology,the first affiliated hospital, Zhejiang University School of medicine, 310003, Qingchun Road 79, Hangzhou city, Zhejiang province, China.
Feng
F
Wang
Department of otorhinolaryngology,the first affiliated hospital, Zhejiang University School of medicine, 310003, Qingchun Road 79, Hangzhou city, Zhejiang province, China.
Yan
Y
Wei
Department of otorhinolaryngology,the first affiliated hospital, Zhejiang University School of medicine, 310003, Qingchun Road 79, Hangzhou city, Zhejiang province, China.
Ya-Ping
YP
Xu
Department of Oncology, The first affiliated hospital,  Zhejiang University School of medicine, 310003, Qingchun Road 79, Hangzhou city, Zhejiang province, China.
Peng
P
Zhao
D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology*; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology*; D006801:Humans; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000032:analysis*; D012333:RNA, Messenger / Q000032:analysis*; D018570:Risk Assessment; D016019:Survival Analysis
D062085:RNA, Long Noncoding; D012333:RNA, Messenger