Pheochromocytoma with Negative Metanephrines: A Rarity and the Significance of Dopamine Secreting Tumors.
We describe a case of a 25-year-old female with a dopamine secreting PPGL diagnosed retrospectively with biochemical analysis. This finding resulted in change in approach to investigation and management, given their important clinical implications. There are important differences in management of dopamine secreting PPGL compared to classical noradrenaline and adrenaline-secreting PPGL. This includes the risk of peri-operative cardiovascular collapse peri-operatively with alpha/beta blockade, risk of malignancy/recurrence, and associated genetic abnormalities.
Department of Urology, Ballarat Health Services, Victoria, Australia; Department of Surgical Oncology, Peter MacCallum Cancer Centre, Victoria, Australia.
Michael
M
Bozin
Department of Surgical Oncology, Peter MacCallum Cancer Centre, Victoria, Australia.
Alastair
A
Lamb
Department of Urology, Ballarat Health Services, Victoria, Australia.
Lydia Johns
LJ
Putra
Dopamine; Paraganglioma; Pheochromocytoma