Increase of circulating α4β7+conventional memory CD4 and regulatory T cells in patients with common variable immunodeficiency (CVID).
This study investigated whether circulating α4β7+expressing T cells could serve as a potential marker for gastrointestinal (GI) disease activity in patients with CVID. The analysis of α4β7+T cells in the peripheral blood of 36 patients and 22 healthy donors (HD) revealed increased percentages of α4β7+conventional memory CD4 T cells and Tregs, but not among CD8 T-cell populations in patients with CVID compared to HD. No differences between patients with and without chronic or acute GI symptoms were observed. EUROClass smB- and 21lo patients, had higher percentages of α4β7+memory CD4 T cells compared to HD and smB+ or 21norm patients, respectively. In summary, the detection of α4β7+T cells in the peripheral blood did not correlate with active or chronic gastrointestinal disease. The increase of these cells in smB- and 21lo patients adds another piece to the immune dysregulation observed in these patients.
Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Karina Mescouto
KM
de Melo
Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Susanne
S
Unger
Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Baerbel
B
Keller
Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Sylvia
S
Gutenberger
Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Ina
I
Stumpf
Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Sigune
S
Goldacker
Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address: klaus.warnatz@uniklinik-freiburg.de.
Klaus
K
Warnatz
D000328:Adult; D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D017074:Common Variable Immunodeficiency / Q000276:immunology*; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D016023:Integrins / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D016023:Integrins; C071777:integrin alpha4beta7
Common variable immunodeficiency; Diagnostics; Enteropathy; Homing; T cell; α4β7