Separation of phytochemicals from Helichrysum italicum: An analysis of different isolation techniques and biological activity of prepared extracts.
Helichrysum italicum presents a valuable source of natural bioactive compounds. In this work, a literature review of terpenes, phenolic compounds, and other less common phytochemicals from H. italicum with regard to application of different separation methods is presented. Data including extraction/separation methods and experimental conditions applied, obtained yields, number of identified compounds, content of different compound groups, and analytical techniques applied are shown as corresponding tables. Numerous biological activities of both isolates and individual compounds are emphasized. In addition, the data reported are discussed, and the directions for further investigations are proposed.
University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11120 Belgrade, Serbia. Electronic address: smaksimovic@tmf.bg.ac.rs.
Svetolik
S
Maksimovic
Institute for Medical Plant Research "Dr Josif Pancic", Tadeusa Koscuska 1, 11000 Belgrade, Serbia. Electronic address: vtadic@mocbilja.rs.
Vanja
V
Tadic
University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11120 Belgrade, Serbia. Electronic address: skala@tmf.bg.ac.rs.
Dejan
D
Skala
University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11120 Belgrade, Serbia. Electronic address: zizovic@tmf.bg.ac.rs.
Irena
I
Zizovic
D005591:Chemical Fractionation / Q000379:methods; D036562:Helichrysum / Q000737:chemistry*; D009822:Oils, Volatile / Q000032:analysis; D010636:Phenols / Q000032:analysis*; D064209:Phytochemicals / Q000032:analysis*; D035261:Plant Components, Aerial / Q000737:chemistry; D010938:Plant Oils / Q000032:analysis; D012997:Solvents / Q000737:chemistry; D013729:Terpenes / Q000032:analysis*
D009822:Oils, Volatile; D010636:Phenols; D064209:Phytochemicals; D010938:Plant Oils; D012997:Solvents; D013729:Terpenes
Asteraceae; Biological activity; Distillation; Extraction by organic solvents; Helichrysum italicum; Phenolic compounds; Supercritical CO(2) extraction; Terpenes