Paper-Based Colorimetric Sensor System for High-Throughput Screening of C-H Borylation.
A paper-based colorimetric sensor system (PBCSS) was developed to detect the amount of bis(pinacolato)diboron (B2Pin2) and applied as a high-throughput screening protocol in Ir-catalyzed C-H borylation. First, 96 ligands were screened for the borylation of benzene, and then 12 of them were selected and tested for five substrates. These reaction mixtures were spotted in the PBCSS, showing a blue-violet color. The value of the gray scale of each reaction was obtained from these colored spots and converted to the extent of conversion of B2Pin2. The extents of conversion of B2Pin2obtained from the PBCSS showed good correlation with those obtained from gas chromatography analysis. In addition, the modified conversion using blank data showed good correlation with the yield of products.
Department of Chemistry, Chonnam National University, Gwangju, 61186, Republic of Korea.
Han-Sung
HS
Kim
Department of Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea.
Min Sik
MS
Eom
Department of Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea.
Min Su
MS
Han
Department of Chemistry, Chonnam National University, Gwangju, 61186, Republic of Korea.
Sunwoo
http://orcid.org/0000-0001-5079-3860
S
Lee
b2pin2; c-h activation; colorimetric sensors; high-throughput screening