Self-Assembling Brush Polymers Bearing Multisaccharides.
Three different series of brush polymers bearing glucosyl, maltosyl, or maltotriosyl moiety at the bristle end are successfully prepared by using cationic ring-opening polymerization and two sequential postmodification reactions. All brush polymers, except for the polymer containing 100 mol% maltotriosyl moiety, demonstrate the formation of multibilayer structure in films, always providing saccharide-enriched surface. These self-assembling features are remarkable, regarding the bulkiness of saccharide moieties and the kink in the bristle due to the triazole linker. The saccharide-enriched film surfaces reveal exceptionally high specific binding affinity to concanavalin A but suppress nonspecific binding of plasma proteins severely. Overall, the brush polymers bearing saccharide moieties of various kinds in this study are highly suitable materials for biomedical applications including biosensors.
Department of Chemistry, Division of Advanced Materials Science, Pohang Accelerator Laboratory, and Polymer Research Institute, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.
Jongchan
J
Lee
Department of Chemistry, Division of Advanced Materials Science, Pohang Accelerator Laboratory, and Polymer Research Institute, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.|Research Centre for Green Fine Chemicals, Chemical Convergence Research Division, Korea Research Institute of Chemical Technology, Ulsan, 44412, Republic of Korea.
Jin Chul
JC
Kim
Department of Chemistry, Division of Advanced Materials Science, Pohang Accelerator Laboratory, and Polymer Research Institute, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.
Hoyeol
H
Lee
Department of Chemistry, Division of Advanced Materials Science, Pohang Accelerator Laboratory, and Polymer Research Institute, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.
Sungjin
S
Song
Department of Microbiology and Dongguk Medical Institute, Dongguk University College of Medicine, Gyeongju, 38066, Republic of Korea.
Heesoo
H
Kim
Department of Chemistry, Division of Advanced Materials Science, Pohang Accelerator Laboratory, and Polymer Research Institute, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.
Moonhor
M
Ree
D015374:Biosensing Techniques / Q000295:instrumentation; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*
D011108:Polymers; D011134:Polysaccharides
multibilayer structure; multisaccharides; proteins; saccharide-containing brush polymers; saccharide-enriched polymer film surface; self-assembly; specific binding