Huntington's Disease-Update on Treatments.
Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disease characterized by progressive motor, behavioral, and cognitive decline, ending in death. Despite the discovery of the underlying genetic mutation more than 20 years ago, treatment remains focused on symptomatic management. Chorea, the most recognizable symptom, responds to medication that reduces dopaminergic neurotransmission. Psychiatric symptoms such as depression and anxiety may also respond well to symptomatic therapies. Unfortunately, many other symptoms do not respond to current treatments. Furthermore, high-quality evidence for treatment of HD in general remains limited. To date, there has been minimal success with identifying a disease-modifying therapy based upon molecular models. However, one of the emerging gene silencing techniques may provide a breakthrough in treating this devastating disease.
Department of Neurology, University of Michigan, 1324 Taubman Center, SPC 5322, 1500 E. Medical Center Drive, Ann Arbor, 48109-5322, USA. wyantk@med.umich.edu.
Kara J
KJ
Wyant
Department of Neurology, University of Michigan, 1324 Taubman Center, SPC 5322, 1500 E. Medical Center Drive, Ann Arbor, 48109-5322, USA.
Andrew J
AJ
Ridder
Department of Neurology, University of Michigan, 1324 Taubman Center, SPC 5322, 1500 E. Medical Center Drive, Ann Arbor, 48109-5322, USA.
Praveen
P
Dayalu
D000818:Animals; D001007:Anxiety / Q000209:etiology; D001519:Behavior; D002819:Chorea / Q000209:etiology; D003072:Cognition Disorders / Q000209:etiology; D003863:Depression / Q000209:etiology; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000175:diagnosis / Q000628:therapy*
Behavioral; Chorea; Cognitive; Huntington; Neurodegeneration; Treatment