Retinol Binding Protein-4 Levels and Non-alcoholic Fatty Liver Disease: A community-based cross-sectional study.
Previous reports on the association between retinol binding protein 4 (RBP4) and nonalcoholic fatty liver disease (NAFLD) were controversial. This study aimed to investigate the association between the serum RBP4 levels and occurrence of NAFLD in Chinese population. In total, 2938 participants aged 40-75 years were involved in this community-based cross-sectional study. General information, lifestyle factors, serum levels of RBP4 and the presence of NAFLD were determined. Patients with NAFLD had significantly higher concentrations of RBP4 (37.9 ± 6.8 μg/ml) than did non-NAFLD controls (35.0 ± 6.7 μg/ml) (P < 0.001). The odds ratios (ORs) of NAFLD for the highest (vs. lowest) quartile of RBP4 were 1.884 (95% CI: 1.391, 2.551) for females (P < 0.001), and 2.107 (95% CI: 1.357, 3.273) for male participants (P < 0.01) after adjusting for related factors. The serum RBP4 levels were positively associated with the prevalence of NAFLD in middle-aged and elderly Chinese people, and Homeostatic model assessment-insulin resistance (HOMA-IR), trunk fat, the waist-to-hip ratio (WHR), systolic blood pressure (SBP), fasting insulin, high density lipoprotein cholesterol (HDL-C) and triglycerides (TG) might be implicated in the pathogenesis of RBP4 in NAFLD.
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, P. R. China.|Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. R. China.
Xuechen
X
Chen
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, P. R. China.|Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. R. China.
Tianran
T
Shen
Department of Epidemiology, School of Public Health, Guilin Medical University, Guilin, P. R. China.
Qing
Q
Li
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, P. R. China.|Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. R. China.
Xu
X
Chen
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, P. R. China.|Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. R. China.
Yanping
Y
Li
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, P. R. China.|Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. R. China.
Dan
D
Li
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. R. China.
Gengdong
G
Chen
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, P. R. China.|Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. R. China.
Wenhua
W
Ling
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, P. R. China.|Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. R. China.
Yu-Ming
YM
Chen
D000328:Adult; D000368:Aged; D015415:Biomarkers; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000209:etiology* / Q000378:metabolism*; D016017:Odds Ratio; D054839:Retinol-Binding Proteins, Plasma / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors
D015415:Biomarkers; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma