The effect of early versus late initiation of renal replacement therapy in patients with acute kidney injury: A meta-analysis with trial sequential analysis of randomized controlled trials.
BACKGROUND
The optimal timing for initiating renal replacement therapy (RRT) in patients with acute kidney injury (AKI) remains controversial.


METHODS
We conducted a meta-analysis with trial sequential analysis (TSA) of randomized controlled trials (RCTs) using PUBMED, Cochrane Library databases, and Web of Science (from January 1, 1985, to August 21, 2016). Adult patients with AKI who received RRT with different timing were included. The primary outcome was mortality. The secondary outcomes were intensive care unit (ICU) length of stay (LOS) and hospital LOS.


RESULTS
We included 9 RCTs with a total of 1636 participants. No differences between the early RRT group and the late RRT group were found with respect to mortality (38% vs 41.4%; relative risk, 0.93; 95% confidence interval [CI], 0.74-1.18). However, TSA showed that the cumulative Z-curve did not cross either the conventional boundary for benefit or the trial sequential monitoring boundary, indicating insufficient evidence. Similarity, there were no findings of benefits in terms of reduction in the ICU LOS (standard difference in the means, -0.32 days; 95% CI, -0.71 to 0.07 days) and hospital LOS (standard difference in the means, -1.11 days; 95% CI, -2.28 to 0.06 days). Meanwhile, the results of TSA did not confirm this conclusion.


CONCLUSIONS
Although conventional meta-analysis showed that early initiation of RRT in patients with AKI was not associated with decreased mortality, ICU LOS and hospital LOS, TSA indicated that the data were far too sparse to make any conclusions. Therefore, well-designed, large RCTs are needed.
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R.China.
Yan-Mei
YM
Feng
Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R.China.
Yuan
Y
Yang
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R.China.
Xiao-Li
XL
Han
School of Public Health and Health Management, Chongqing Medical University, Chongqing, P.R.China.
Fan
F
Zhang
Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R.China.
Dong
D
Wan
Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R.China.
Rui
R
Guo
D058186:Acute Kidney Injury / Q000401:mortality / Q000628:therapy*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D017582:Renal Replacement Therapy / Q000379:methods