Muscular damage in a patient with hepatitis B induced by beta-l-2'-deoxythymidine and detected by18F-FDG PET/CT.
A 58 years old man under 2'-Deoxy-L-thymidine treatment for his hepatitis B was admitted to our hospital complaining for the last 2 months of recurrent upper abdomen discomfort, fatigue and weight loss of 10 kilograms and general muscular soreness, for 2 weeks. He had elevated creatine kinase (CK), myoglobin, CK-MB and other related or common laboratory findings. Fluorine-18- fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG PET/CT) showed a diffuse, homogenous, moderately elevated glucose uptake in all muscle groups. Muscular damage induced by 2'-Deoxy-L-thymidine was suspected and the drug was discontinued. Muscle soreness and the biomarkers for muscular tissue damage improved. Fluorine-18-FDG PET/CT is useful to rule out malignancy and identify muscular tissue damage.
Linyi People's Hospital, Linyi, Shandong, China, East Jiangfang Road 27 Linyi, 276000, China. lyzhangqingjun@126.com.
Jinhua
J
Zi
Changyun
C
Xu
Xuemei
X
Zhang
D003937:Diagnosis, Differential; D019788:Fluorodeoxyglucose F18; D006509:Hepatitis B / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D000077712:Telbivudine; D013936:Thymidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D000077712:Telbivudine; D013936:Thymidine