Microscopic and ultrastructural evidences in human skin following calcium hydroxylapatite filler treatment.
This study uses light and electron microscopes to gain a better knowledge of the interactions of calcium hydroxylapatite filler with the connective tissue of the skin and the modifications of the human deep dermis, after 2 months of treatment. Some morphological evidences of this observational study of filler treated tissue support-specific mechanism involved in the structural modifications of both filler microspherules and cells of the connective tissue. They demonstrate the absence of any immunological reaction and show that the used filler is modified very slowly over time by the action of cells of the connective tissue closely related to the filler without any activity of phagocytosis. Furthermore, associated with the modifications of the filler, evidences of stimulatory effects on dermal fibroblasts are reported.
Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy. nzerbinati@centro-medico.it.
Nicola
N
Zerbinati
Dermatology Department Centro Medico Polispecialistico, Pavia, Italy.
Edoardo
E
D'Este
Department of Medical, Experimental and Clinical Sciences, University of Udine, Udine, Italy.
Pier Camillo
PC
Parodi
Department of Public Health, Experimental and Forensic Medicine, Histology and Embryology Unit, University of Pavia, Pavia, Italy.
Alberto
A
Calligaro
D001672:Biocompatible Materials / Q000494:pharmacology*; D003238:Connective Tissue / Q000187:drug effects*; D017886:Durapatite / Q000494:pharmacology*; D005260:Female; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D008854:Microscopy, Electron; D012867:Skin / Q000648:ultrastructure*; D015595:Skin Aging / Q000187:drug effects*
D001672:Biocompatible Materials; D017886:Durapatite
Hydroxylapatite; Skin; Ultrastructure