Reversible Alopecia with Localized Scalp Necrosis After Accidental Embolization of the Parietal Artery with Hyaluronic Acid.
Hyaluronic acid (HA) filler injection is widely used for soft-tissue augmentation. Complications associated with HA filling are not uncommon; however, HA-induced alopecia is a rarely reported complication that could result in severe secondary psychological trauma. The etiology, clinical traits, treatment strategies, outcomes, and possible reversibility of HA-induced alopecia have not been characterized. Here, we report a case in which bilateral temple injections of 6.5 mL of HA led to persistent pain over the left scalp for several days. Although the pain was relieved at day 9 after 600 U of hyaluronidase were injected in the left temple, the patient developed localized alopecia at the left temporoparietal region with central skin necrosis at day 15. After topical applications of recombinant bovine basic fibroblast growth factor gel and 2% minoxidil spay, the necrotic skin wound was healed at day 42. Hair regrowth and normal hair density were restored at day 74. Analyses of Doppler ultrasound examinations and histopathology of the skin biopsy suggested that mild ischemia of the left temporoparietal region led to reversible alopecia, while the permanent hair loss in the left parietal area was associated with severe skin ischemia. Therefore, the key to treatment would be to focus on the effective correction of severe ischemia-induced skin necrosis to prevent permanent hair loss. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No. 127, Changle West Road, Xi'an, 710032, Shaanxi, China.
Qing
Q
Yang
Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No. 127, Changle West Road, Xi'an, 710032, Shaanxi, China.
Lihong
L
Qiu
Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No. 127, Changle West Road, Xi'an, 710032, Shaanxi, China.
Chenggang
C
Yi
Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No. 127, Changle West Road, Xi'an, 710032, Shaanxi, China.
Ping
P
Xue
Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No. 127, Changle West Road, Xi'an, 710032, Shaanxi, China.
Zhou
Z
Yu
Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No. 127, Changle West Road, Xi'an, 710032, Shaanxi, China.
Xianjie
X
Ma
Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No. 127, Changle West Road, Xi'an, 710032, Shaanxi, China. suyingjun@fmmu.edu.cn.
Yingjun
Y
Su
Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No. 127, Changle West Road, Xi'an, 710032, Shaanxi, China. xjzx2011@fmmu.edu.cn.
Shuzhong
S
Guo
D000328:Adult; D000505:Alopecia / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D001157:Arterial Occlusive Diseases / Q000139:chemically induced* / Q000473:pathology; D001158:Arteries / Q000473:pathology; D001707:Biopsy, Needle; D003357:Cosmetic Techniques / Q000009:adverse effects; D000067548:Dermal Fillers / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D005500:Follow-Up Studies; D006197:Hair / Q000254:growth & development*; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D007150:Immunohistochemistry; D008914:Minoxidil / Q000627:therapeutic use; D009336:Necrosis / Q000209:etiology / Q000473:pathology; D010294:Parietal Bone / Q000098:blood supply* / Q000187:drug effects; D020127:Recovery of Function; D012535:Scalp / Q000098:blood supply / Q000187:drug effects / Q000473:pathology*; D018615:Ultrasonography, Doppler, Color / Q000379:methods
D000067548:Dermal Fillers; D008914:Minoxidil; D006820:Hyaluronic Acid
Alopecia; Hyaluronic acid; Hyaluronidase