Tripodal squaramide conjugates as highly effective transmembrane anion transporters.
Two tripodal squaramide conjugates having 4-(trifluoromethyl)phenyl and 3,5-bis(trifluoromethyl)phenyl substituents were synthesized and found to exhibit highly efficient transmembrane anion transport with the EC50values being 0.14 and 0.75mol%, respectively. Though one of them has been reported to act as a strong anion receptor, in particular for sulfate anions, these two compounds exhibit no significant selectivity with respect to the tested monovalent anions and a very low level of activity in the presence of sulfate anions.
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Xiong-Jie
XJ
Cai
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Zhi
Z
Li
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China. Electronic address: whchen@smu.edu.cn.
Wen-Hua
WH
Chen
D000838:Anions / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism; D054879:Halogenation; D017136:Ion Transport / Q000187:drug effects*; D008081:Liposomes / Q000378:metabolism; D008745:Methylation; D011803:Quinine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013431:Sulfates / Q000378:metabolism
D000838:Anions; D002712:Chlorides; D008081:Liposomes; D013431:Sulfates; C000609819:squaramide; D011803:Quinine
Anionophore; Anionophoric activity; Ion selectivity; Squaramide