Optical and electrochemical dual channel sensing of Cu2+using functionalized furo[2,3-d]pyrimidines-2,4[1H,3H]-diones.
Owing to their easy accessibility and high degree of structural and functional diversity, many multicomponent reactions (MCRs) have been a rich source of conjugate π-systems, functionalised chromophores (or fluorophore) and redox active molecules. Despite their high explorative potential and practical benefits, only a few MCR products have been so far investigated for their metal sensing abilities. In the present report, two furopyrimidinones (FPys) based molecular systems have been synthesized by [4+1] cycloaddition based MCR sequence. Designed chemosensors displayed optic (absorption spectra) as well as electroanalytical (ion selective electrode) response toward Cu2+ion in solution and membrane phase respectively (dual channel sensing). Different aspects of both the sensing phenomena such as selectivity, association constants, detection limit, membrane composition etc. were studied in detail using UV-Vis spectroscopy, NMR titration and cell assembly. Both the compounds showed excellent performance characteristics such as high selectivity, acceptable affinity and low detection limits (10-7M) in both sensing assays with potential utility in the area of sample monitoring.
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India.
Manoj
M
Kumar
Department of Applied Chemistry, University of Johannesburg, Johannesburg, South Africa.
Lokesh Kumar
LK
Kumawat
Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh 530045, India.
Priyanka
P
Bhatt
Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh 530045, India.
Anjali
A
Jha
Department of Applied Chemistry, University of Johannesburg, Johannesburg, South Africa.
Shilpi
S
Agarwal
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India. Electronic address: anujsfcy@iitr.ac.in.
Anuj
A
Sharma
Department of Applied Chemistry, University of Johannesburg, Johannesburg, South Africa. Electronic address: vinodg@uj.ac.za.
Vinod Kumar
VK
Gupta
Dual channel sensing; Furopyrimidinones; ISE; MCR; Sensor