[Ex vivo assessment of the potency of optical coherence tomography for the detection of early occlusal caries].
OBJECTIVE
This study aimed to evaluate the potency of optical coherence tomography (OCT) to detect early occlusal caries compared with clinical visual examination.


METHODS
Approximately 97 sites of occlusal fissures on 77 extracted accessional human teeth were scored by three examiners using conventional visual examination and OCT. Results of histological examination on these sites obtained by polarimicroscope served as a gold standard to analyze the sensitivity (SE), specificity (SP), positive predictive value (PPV), and negative predictive value (NPV). Results of the area under receiver operating characteristic (ROC) curve (AUC) by visual examination and OCT were also analyzed. The Spearman's rank correlation coefficient with histology and the inter-examiner reliability were compared.


RESULTS
For sites of enamel demineralization limited to the outer 1/2 of the enamel layer, the detection rate of OCT (14/25) was obviously higher than that of the clinical and visual examination (3/25). SE, SP, PPV and NPV of OCT during diagnosis of the early occlusal caries (0.83, 0.64, 0.87 and 0.57) were higher than that of the visual examination (0.79, 0.60, 0.85 and 0.50). AUC (95%CI) of OCT and the visual examination were 0.737 (0.569-0.822) and 0.696 (0.614-0.859), respectively. No statistically significant difference was observed between the results. Results of OCT correlated well with histology (r=0.559, P<0.05). The inter-examiner reliability of OCT was medium.


CONCLUSIONS
OCT can accurately detect early occlusal lesions atraumatically with high sensitivity and effectiveness. OCT exhibits the potential of auxiliary clinical diagnosis enhancing detection rate and finally implementing early diagnosis and early intervention of early occlusal lesions in clinical practice.
Experimental Research Center, Tianjin Stomatology Hospital, Tianjin 300041, China.
Dai
D
Xiao-Hua
Experimental Research Center, Tianjin Stomatology Hospital, Tianjin 300041, China.
Yao
Y
Hui
Experimental Research Center, Tianjin Stomatology Hospital, Tianjin 300041, China.
Lian
L
Xiaoli
Experimental Research Center, Tianjin Stomatology Hospital, Tianjin 300041, China.
Li
L
Yanni
Dept. of Conservative Dentistry and Endodontics, Tianjin Stomatology Hospital, Tianjin 300041, China.
Wang
W
Yingying
Dept. of Conservative Dentistry and Endodontics, Tianjin Stomatology Hospital, Tianjin 300041, China.
Liu
L
Xiaobin
Dept. of Conservative Dentistry and Endodontics, Tianjin Stomatology Hospital, Tianjin 300041, China.
Xing
X
Lu
D003731:Dental Caries; D003743:Dental Enamel; D006801:Humans; D012372:ROC Curve; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence
early caries; occlusal caries; optical coherence tomography; visual examination