Assessment of Longitudinal Reproducibility of Mice LV Function Parameters at 11.7 T Derived from Self-Gated CINE MRI.
The objective of this work was the assessment of the reproducibility of self-gated cardiac MRI in mice at ultra-high-field strength. A group of adult mice (n= 5) was followed over 360 days with a standardized MR protocol including reproducible animal position and standardized planning of the scan planes. From the resulting CINE MRI data, global left ventricular (LV) function parameters including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and left ventricular mass (LVM) were quantified. The reproducibility of the self-gated technique as well as the intragroup variability and longitudinal changes of the investigated parameters was assessed. Self-gated cardiac MRI proved excellent reproducibility of the global LV function parameters, which was in the order of the intragroup variability. Longitudinal assessment did not reveal any significant variations for EDV, ESV, SV, and EF but an expected increase of the LVM with increasing age. In summary, self-gated MRI in combination with a standardized protocol for animal positioning and scan plane planning ensures reproducible assessment of global LV function parameters.
Department of Internal Medicine II, University Hospital Ulm, Ulm, Germany; Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China; Core Facility Small Animal MRI, Medical Faculty, Ulm University, Ulm, Germany.
Zhi
Z
Zuo
Core Facility Small Animal MRI, Medical Faculty, Ulm University, Ulm, Germany.
Anne
A
Subgang
Core Facility Small Animal MRI, Medical Faculty, Ulm University, Ulm, Germany.
Alireza
A
Abaei
Department of Internal Medicine II, University Hospital Ulm, Ulm, Germany.
Wolfgang
W
Rottbauer
In-Vivo Imaging, Drug Development, Boehringer Ingelheim Pharma Gmbh & Co. KG, Biberach, Germany.
Detlef
D
Stiller
Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.
Genshan
G
Ma
Department of Internal Medicine II, University Hospital Ulm, Ulm, Germany; Core Facility Small Animal MRI, Medical Faculty, Ulm University, Ulm, Germany.
Volker
0000-0001-8844-3583
V
Rasche
D000818:Animals; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D051379:Mice; D015203:Reproducibility of Results; D013318:Stroke Volume / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*