Marine Peptides as Potential Agents for the Management of Type 2 Diabetes Mellitus-A Prospect.
An increasing prevalence of diabetes is known as a main risk for human health in the last future worldwide. There is limited evidence on the potential management of type 2 diabetes mellitus using bioactive peptides from marine organisms, besides from milk and beans. We summarized here recent advances in our understanding of the regulation of glucose metabolism using bioactive peptides from natural proteins, including regulation of insulin-regulated glucose metabolism, such as protection and reparation of pancreatic β-cells, enhancing glucose-stimulated insulin secretion and influencing the sensitivity of insulin and the signaling pathways, and inhibition of bioactive peptides to dipeptidyl peptidase IV, α-amylase and α-glucosidase activities. The present paper tried to understand the underlying mechanism involved and the structure characteristics of bioactive peptides responsible for its antidiabetic activities to prospect the utilization of rich marine organism proteins.
Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China. enqinxia@163.com.
En-Qin
EQ
Xia
Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China. zss90y@163.com.
Shan-Shan
SS
Zhu
Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China. minjinghe0818@163.com.
Min-Jing
MJ
He
Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China. luofei_00@163.com.
Fei
F
Luo
Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China. fuchengzhan@126.com.
Cheng-Zhan
CZ
Fu
Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China. zoutb@163.com.
Tang-Bin
TB
Zou
D059001:Aquatic Organisms / Q000737:chemistry*; D001786:Blood Glucose / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D018819:Dipeptidyl Peptidase 4 / Q000737:chemistry / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D000516:alpha-Amylases / Q000737:chemistry / Q000494:pharmacology; D000520:alpha-Glucosidases / Q000737:chemistry / Q000494:pharmacology
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010455:Peptides; D000516:alpha-Amylases; D000520:alpha-Glucosidases; D018819:Dipeptidyl Peptidase 4; D005947:Glucose
bioactive peptide; glucose metabolism; marine protein; regulation; structure active relationship