Monoamine Transporters as Ionotropic Receptors.
It is well established that glutamate and GABA signal through both ionotropic and metabotropic receptors. Conversely, it is thought that, with one exception, monoamines (dopamine, serotonin, and norepinephrine) signal via metabotropic receptors. Given their capacity to generate fast-acting currents, I suggest that the monoamine transporters should be considered as ionotropic receptors.
Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA 23284, USA.
Louis J
LJ
De Felice
D000818:Animals; D009474:Neurons / Q000378:metabolism; D050480:Plasma Membrane Neurotransmitter Transport Proteins / Q000378:metabolism*; D058468:Receptors, Ionotropic Glutamate / Q000378:metabolism*; D050493:Vesicular Monoamine Transport Proteins / Q000378:metabolism*
D050480:Plasma Membrane Neurotransmitter Transport Proteins; D058468:Receptors, Ionotropic Glutamate; D050493:Vesicular Monoamine Transport Proteins