Optic nerve head in central retinal vein occlusion by spectral-domain OCT.
OBJECTIVE
To evaluate the morphology of optic nerve head by spectral-domain optical coherence tomography (SD-OCT) in patients with unilateral central retinal vein occlusion (CRVO).


METHODS
In 39 consecutive patients with unilateral CRVO and 39 healthy controls, morphologic parameters of optic nerve head were assessed in both eyes by Spectralis SD-OCT using a custom radial B-scan pattern. The length of Bruch membrane opening (BMO) was measured in OCT scans, and optic disc diameters (DD) were assessed in infrared fundus photographs. Axial length was determined by IOLMaster.


RESULTS
The BMO length was measured in all eyes with CRVO, while DD was not assessed in 9 eyes (27.3%) that had undefined disc margins. Compared to healthy controls (mean BMO length 1,511 ± 79 μm, mean disc diameter 1,521 ± 77 μm), in eyes with CRVO with defined disc margins (n = 28 [71.8%]), no significant difference was found in BMO length and DD (1,473 ± 118 μm and 1,516 ± 104 μm, respectively). Eyes with CRVO with undefined disc margins had lower BMO length (1,289 ± 61 μm [-14.7%], p = 0.001); also, in fellow eyes, these patients had lower BMO length and DD. In all groups, no significant difference was seen between BMO and DD. A correlation was found between axial length and BMO length and disc diameter (both p<0.001).


CONCLUSIONS
Most of the eyes with CRVO had normal optic disc diameter, but about 25% of patients with CRVO have reduced optic disc dimensions.
Eye Clinic, University of Catania, Catania - Italy.
Antonio
A
Longo
Eye Clinic, University of Catania, Catania - Italy.
Teresio
T
Avitabile
Eye Clinic, University of Catania, Catania - Italy.
Maurizio G
MG
Uva
Eye Clinic, University of Catania, Catania - Italy.
Vincenza
V
Bonfiglio
Eye Clinic, University of Catania, Catania - Italy.
Andrea
A
Russo
Eye Clinic, University of Catania, Catania - Italy.
Mario D
MD
Toro
Eye Clinic, University of Catania, Catania - Italy.
Caterina
C
Gagliano
Eye Clinic, University of Catania, Catania - Italy.
Matteo
M
Fallico
Eye Clinic, University of Catania, Catania - Italy.
Michele
M
Reibaldi
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D058452:Axial Length, Eye; D016570:Bruch Membrane / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000000981:diagnostic imaging / Q000473:pathology*; D010781:Photography; D012170:Retinal Vein Occlusion / Q000000981:diagnostic imaging / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*