Behavioral and neurochemical effects of alpha lipoic acid associated with omega-3 in tardive dyskinesia induced by chronic haloperidol in rats.
Tardive dyskinesia (TD) is characterized by involuntary movements of the lower portion of the face being related to typical antipsychotic therapy. TD is associated with the oxidative imbalance in the basal ganglia. Lipoic acid (LA) and omega-3 (ω-3) are antioxidants acting as enzyme cofactors, regenerating antioxidant enzymes. This study aimed to investigate behavioral and neurochemical effects of supplementation with LA (100 mg/kg) and ω-3 (1 g/kg) in the treatment of TD induced by chronic use of haloperidol (HAL) (1 mg/kg) in rats. Wistar male rats were used, weighing between 180-200 g. The animals were treated chronically (31 days) with LA alone or associated with HAL or ω-3. Motor behavior was assessed by open-field test, the catalepsy test, and evaluation of orofacial dyskinesia. Oxidative stress was accessed by determination of lipid peroxidation and concentration of nitrite. LA and ω-3 alone or associated caused an improvement in motor performance by increasing locomotor activity in the open-field test and decreased the permanence time on the bar in the catalepsy test and decreased the orofacial dyskinesia. LA and ω-3 showed antioxidant effects, decreasing lipid peroxidation and nitrite levels. Thus, the use of LA associated with ω-3 reduced the extrapyramidal effects produced by chronic use of HAL.
a Nursing Department, State University of Rio Grande do Norte - UERN/FAEN, Mossoró, RN, Brazil.
Dayane Pessoa
DP
de Araújo
b Students of Medicine, Department of Medicine, College of Health Sciences, State University of Rio Grande do Norte - UERN/FACS, Mossoró, RN, Brazil.
Thaisa Gracielle Martins
TGM
Camboim
b Students of Medicine, Department of Medicine, College of Health Sciences, State University of Rio Grande do Norte - UERN/FACS, Mossoró, RN, Brazil.
Ana Patrícia Magalhães
APM
Silva
b Students of Medicine, Department of Medicine, College of Health Sciences, State University of Rio Grande do Norte - UERN/FACS, Mossoró, RN, Brazil.
Caio da Fonseca
CDF
Silva
b Students of Medicine, Department of Medicine, College of Health Sciences, State University of Rio Grande do Norte - UERN/FACS, Mossoró, RN, Brazil.
Rebeca Canuto
RC
de Sousa
b Students of Medicine, Department of Medicine, College of Health Sciences, State University of Rio Grande do Norte - UERN/FACS, Mossoró, RN, Brazil.
Mabson Delâno Alves
MDA
Barbosa
a Nursing Department, State University of Rio Grande do Norte - UERN/FAEN, Mossoró, RN, Brazil.
Lucidio Clebeson
LC
Oliveira
c Department of Medicine, College of Health Sciences, State University of Rio Grande do Norte - UERN/FACS, Mossoró, RN, Brazil.
José Rodolfo Lopes de Paiva
JRLP
Cavalcanti
d Department of Dentistry, State University of Rio Grande do Norte - UERN, Mossoró, RN, Brazil.
Eudes Euler de Souza
EES
Lucena
c Department of Medicine, College of Health Sciences, State University of Rio Grande do Norte - UERN/FACS, Mossoró, RN, Brazil.
Fausto Pierdoná
FP
Guzen
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004347:Drug Interactions; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology* / Q000627:therapeutic use; D006220:Haloperidol / Q000009:adverse effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009448:Neurochemistry; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D000071057:Tardive Dyskinesia / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D008063:Thioctic Acid / Q000494:pharmacology* / Q000627:therapeutic use
D015525:Fatty Acids, Omega-3; D017392:Thiobarbituric Acid Reactive Substances; D008063:Thioctic Acid; D006220:Haloperidol
acide lipoïque; dyskinésie tardive; haloperidol; halopéridol; lipoic acid; omega-3; oméga 3; oxidative stress; stress oxydatif; tardive dyskinesia