[Calcilytic drugs:Feature and future.]
Calcium-sensing receptor(CaSR)is highly expressed in parathyroid, kidney, bone, and small and large intestines to regulate Ca homeostasis. Calcilytics are allosteric antagonists of CaSR, and stimulate endogenous PTH release. Several calcilytics have been evaluated as anabolic therapies for postmenopausal osteoporosis but clinical development of all of them has been abandoned because the lacked clinical efficacy. Calcilytics might be repurposed for new indications like autosomal dominant hypocalcemia or other disorders.
Department of Hematology，Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan.
Itsuro
I
Endo
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy; D044169:Receptors, Calcium-Sensing / Q000037:antagonists & inhibitors*
D044169:Receptors, Calcium-Sensing; D002118:Calcium