The High Prevalence of Vitamin D Insufficiency in Cord Blood in Calgary, Alberta (APrON-D Study).
OBJECTIVE
Vitamin D is important in promoting healthy pregnancy and fetal development. We undertook this study to measure 25-hydroxyvitamin D in maternal and cord blood and to identify maternal factors related to vitamin D status in Calgary.


METHODS
Blood samples collected at the time of delivery from the Alberta Pregnancy Outcomes and Nutrition study cohort (ApronStudy.ca) participants were processed for plasma and assayed using liquid chromatography mass spectrometry methodology for 25(OH)D3.


RESULTS
Ninety-two pairs of maternal and cord blood samples were obtained. The prevalence of 25(OH)D3insufficiency-25(OH)D3<75 nmol/L-was 38% and 80% in women and neonates, respectively. Vitamin D supplementation was the only clinical factor associated with 25(OH)D3sufficiency, and the odds of sufficiency were 3.75 (95% CI 1.00 to 14.07) higher for women and 5.27 (95% CI 1.37 to 20.27) when over 2000 IU/day were used.


CONCLUSIONS
Using liquid chromatography mass spectrometry, we demonstrated a very high prevalence of vitamin D insufficiency in cord blood and that the use of high dose vitamin D was associated with greater odds of sufficiency in pregnant women and cord blood in Alberta.
Departments of Family Medicine and Community Health Sciences, University of Calgary, Calgary, AB.
Fariba
F
Aghajafari
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB.
Catherine J
CJ
Field
Departments of Paediatrics and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB.
Bonnie J
BJ
Kaplan
Research and Development, Doctor's Data, Inc., St. Charles, IL.
Jack A
JA
Maggiore
Departments of Family Medicine and Community Health Sciences, University of Calgary, Calgary, AB.
Maeve
M
O'Beirne
Departments of Medicine, Oncology, and Community Health Sciences, University of Calgary, Calgary, AB.
David A
DA
Hanley
Department of Public Health and Community Medicine, Tufts University, Boston, MA.
Misha
M
Eliasziw
Departments of Paediatrics and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB.
Deborah
D
Dewey
Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB.
Sue
S
Ross
O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, AB. Electronic address: Doreen.Rabi@albertahealthservices.ca.
Doreen
D
Rabi
D000328:Adult; D000416:Alberta / Q000453:epidemiology; D002112:Calcifediol / Q000097:blood / Q000172:deficiency; D015331:Cohort Studies; D019587:Dietary Supplements; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000453:epidemiology; D014807:Vitamin D / Q000008:administration & dosage / Q000097:blood*; D014808:Vitamin D Deficiency / Q000150:complications / Q000453:epidemiology*
D014807:Vitamin D; D002112:Calcifediol
25(OH)D; Vitamin D; cord blood; liquid chromatography mass spectrometry; pregnancy