Molecular mechanisms involved in the interaction of Neisseria meningitidis with cells of the human blood-cerebrospinal fluid barrier.
Neisseria meningitidis is one of the most common aetiological agents of bacterial meningitis, affecting predominantly children and young adults. The interaction of N. meningitidis with human endothelial cells lining blood vessels of the blood-cerebrospinal fluid barrier (B-CSFB) is critical for meningitis development. In recent decades, there has been a significant increase in understanding of the molecular mechanisms involved in the interaction of N. meningitidis with brain vascular cells. In this review, we will describe how N. meningitidis adheres to the brain vasculature, may enter inside these cells, hijack receptor signalling pathways and alter host-cell responses in order to traverse the B-CSFB.
Alexandra
A
Schubert-Unkmeir
D000818:Animals; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000276:immunology / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000166:cytology* / Q000378:metabolism* / Q000382:microbiology; D042783:Endothelial Cells / Q000378:metabolism / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D008585:Meningitis, Meningococcal / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology*; D009345:Neisseria meningitidis / Q000472:pathogenicity / Q000502:physiology*; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction; D013107:Sphingolipids / Q000378:metabolism; D059467:Transcriptome; D037521:Virulence Factors / Q000378:metabolism
D001426:Bacterial Proteins; D011956:Receptors, Cell Surface; D013107:Sphingolipids; D037521:Virulence Factors
Neisseria meningitidis; blood–cerebrospinal fluid barrier; ceramide; signal-transduction mechanisms; surface adhesins and invasins