B cells and atherosclerosis.
B cells have emerged as important immune cells in cardiovascular disease. Initial studies have suggested that B cells protect against atherosclerosis development. However, subsequent studies demonstrating aggravation of atherosclerosis by B-2 cells have shed light on the subset-dependent effects of B cells. Here, we review the literature that has led to our current understanding of B cell regulation of atherosclerosis, touching on the importance of subsets, local regulation, human translation, and therapeutic potential.
Cardiovascular Research Center, Charlottesville, Virginia; and ps5fj@virginia.edu.
Prasad
P
Srikakulapu
Cardiovascular Research Center, Charlottesville, Virginia; and.|Division of Cardiovascular Medicine, Department of Medicine, University of Virginia, Charlottesville, Virginia.
Coleen A
CA
McNamara
D000818:Animals; D001158:Arteries / Q000276:immunology*; D050197:Atherosclerosis / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007155:Immunologic Factors / Q000276:immunology*; D018448:Models, Immunological
D016207:Cytokines; D007155:Immunologic Factors
B cells; IgM; atherosclerosis; inflammation