Distribution of 1,2-dichloropropane in blood and other tissues of rats after oral administration.
The present investigation was undertaken to determine the distribution of 1,2-dichloropropane (DCP) in the blood, liver, kidney, lung, and abdominal fat of rats after oral administration. Male rats were orally administered 62 or 125 mg/kg body weight doses of DCP dissolved in corn oil by gavage, and the concentrations in the blood and tissues were measured. The DCP concentration in the abdominal fat was much greater than in the blood and other tissues. Twenty-four-hr after oral administration, DCP could still be detected in the blood and abdominal fat in the 62-mg/kg group, and in the blood, liver, kidney, lung, and abdominal fat in the 125-mg/kg group. Our results are valuable data pertaining to the pharmacokinetics of DCP and to human health risk assessment of oral exposure to DCP.
Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety.
Makoto
M
Take
Tetsuya
T
Takeuchi
Shigeyuki
S
Hirai
Kenji
K
Takanobu
Michiharu
M
Matsumoto
Shoji
S
Fukushima
Jun
J
Kanno
D050153:Abdominal Fat / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D004785:Environmental Pollutants / Q000097:blood / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D011407:Propane / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D011916:Rats, Inbred F344; D012997:Solvents / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D004785:Environmental Pollutants; D012997:Solvents; C004765:propylene dichloride; D011407:Propane