One-pot synthesis of alternating peptides exploiting a new polymerization technique based on Ugi's 4CC reaction.
We developed a one-pot synthetic technique for alternating peptides. Central to this technique is a new, catalyst-free polymerization based on Ugi's 4CC reaction. The treatment of imines with the ambident molecules bearing both an isocyanide and a carboxylic acid afforded alternating peptides.
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. ykoyama@pu-toyama.ac.jp.
Yasuhito
http://orcid.org/0000-0002-6985-4499
Y
Koyama
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. ykoyama@pu-toyama.ac.jp.
Prashant G
PG
Gudeangadi
D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D058105:Polymerization
D000447:Aldehydes; D000588:Amines; D002264:Carboxylic Acids; D009570:Nitriles; D010455:Peptides