Fe(III)-based metal-organic framework-derived core-shell nanostructure: Sensitive electrochemical platform for high trace determination of heavy metal ions.
A new core-shell nanostructured composite composed of Fe(III)-based metal-organic framework (Fe-MOF) and mesoporous Fe3O4@C nanocapsules (denoted as Fe-MOF@mFe3O4@mC) was synthesized and developed as a platform for determining trace heavy metal ions in aqueous solution. Herein, the mFe3O4@mC nanocapsules were prepared by calcining the hollow Fe3O4@C that was obtained using the SiO2nanoparticles as the template, followed by composing the Fe-MOF. The Fe-MOF@mFe3O4@mC nanocomposite demonstrated excellent electrochemical activity, water stability and high specific surface area, consequently resulting in the strong biobinding with heavy-metal-ion-targeted aptamer strands. Furthermore, by combining the conformational transition interaction, which is caused by the formation of the G-quadruplex between a single-stranded aptamer and high adsorbed amounts of heavy metal ions, the developed aptasensor exhibited a good linear relationship with the logarithm of heavy metal ion (Pb2+and As3+) concentration over the broad range from 0.01 to 10.0nM. The detection limits were estimated to be 2.27 and 6.73 pM toward detecting Pb2+and As3+, respectively. The proposed aptasensor showed good regenerability, excellent selectivity, and acceptable reproducibility, suggesting promising applications in environment monitoring and biomedical fields.
Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, No. 136, Science Avenue, Zhengzhou, Henan 450001, PR China. Electronic address: mainzhh@163.com.
Zhihong
Z
Zhang
Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, No. 136, Science Avenue, Zhengzhou, Henan 450001, PR China. Electronic address: t_mac3513@126.com.
Hongfei
H
Ji
Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, No. 136, Science Avenue, Zhengzhou, Henan 450001, PR China. Electronic address: wangpan8624@163.com.
Yingpan
Y
Song
Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, No. 136, Science Avenue, Zhengzhou, Henan 450001, PR China. Electronic address: zschina2009@163.com.
Shuai
S
Zhang
Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, No. 136, Science Avenue, Zhengzhou, Henan 450001, PR China. Electronic address: wangminghua@zzuli.edu.cn.
Minghua
M
Wang
Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, No. 136, Science Avenue, Zhengzhou, Henan 450001, PR China. Electronic address: gfdy1688@163.com.
Changchang
C
Jia
Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, No. 136, Science Avenue, Zhengzhou, Henan 450001, PR China. Electronic address: tjykidlydz@163.com.
Jia-Yue
JY
Tian
Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, No. 136, Science Avenue, Zhengzhou, Henan 450001, PR China. Electronic address: helinghao@zzuli.edu.cn.
Linghao
L
He
Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, No. 136, Science Avenue, Zhengzhou, Henan 450001, PR China. Electronic address: zhangxiaojing@zzuli.edu.cn.
Xiaojing
X
Zhang
Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, No. 136, Science Avenue, Zhengzhou, Henan 450001, PR China. Electronic address: chunsenliu@zzuli.edu.cn.
Chun-Sen
CS
Liu
D015374:Biosensing Techniques / Q000379:methods*; D004563:Electrochemistry / Q000379:methods*; D004784:Environmental Monitoring; D005290:Ferric Compounds / Q000737:chemistry; D054856:G-Quadruplexes; D007477:Ions / Q000737:chemistry; D057230:Limit of Detection; D000073396:Metal-Organic Frameworks / Q000737:chemistry; D019216:Metals, Heavy / Q000302:isolation & purification*; D049329:Nanostructures; D012822:Silicon Dioxide / Q000737:chemistry
D005290:Ferric Compounds; D007477:Ions; D000073396:Metal-Organic Frameworks; D019216:Metals, Heavy; D012822:Silicon Dioxide
Aptasensor; Core–shell nanostructure; Detection of heavy metal ion trace; Fe-MOF@mFe(3)O(4)@mC