Palladium-catalyzed highly regioselective hydroaminocarbonylation of aromatic alkenes to branched amides.
Pd(t-Bu3P)2has been successfully identified as an efficient catalyst for the hydroaminocarbonylation of aromatic alkenes to branched amides under relatively mild reaction conditions. With hydroxylamine hydrochloride as an additive, both aliphatic and aromatic amines could be used as coupling partners for the present reaction, leading to production of branched amides in high yields with excellent regioselectivities.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310024, China. hanmin@ustc.edu.cn.
Jinping
J
Zhu
Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
Bao
B
Gao
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310024, China. hanmin@ustc.edu.cn and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
Hanmin
http://orcid.org/0000-0002-0108-6542
H
Huang