Eosinophilic dermatosis of hematologic malignancy.
We report a 68-year-old woman with chroniclymphocytic leukemia, who developed numerous,pruritic, edematous, and vesicobullous skin lesionsof the face and extremities over the course of severalmonths. The diagnosis of eosinophilic dermatosis ofhematologic malignancy (EDHM) was made basedon the clinical history and histopathologic features.Owing to the possible link between EDHM and amore aggressive underlying CLL, she was startedagain on chemotherapy. This case serves as areminder that, although the precise pathogenesis ofEDHM remains unclear, the paraneoplastic disorderis the result of immune dysregulation. Patientswho develop EDHM should undergo prompthematologic/oncologic evaluation.
Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.
Kathryn
K
Martires
Shields
S
Callahan
Vitaly
V
Terushkin
Nooshin
N
Brinster
Marie
M
Leger
Nicholas A
NA
Soter
D000368:Aged; D004802:Eosinophilia / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D005148:Facial Dermatoses / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D012871:Skin Diseases / Q000150:complications / Q000175:diagnosis* / Q000473:pathology