Bone Mass in Boys with Autism Spectrum Disorder.
To examine bone mass in children and adolescents with autism spectrum disorders (ASD). Risperidone-treated 5 to 17 year-old males underwent anthropometric and bone measurements, using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Multivariable linear regression analysis models examined whether skeletal outcomes differed among participants with (n = 30) versus without ASD (n = 156). After adjusting for potential covariates, having ASD was associated with significantly lower trabecular bone mineral density and bone strength at the radius, and with marginally lower total body less head bone mineral content (p < 0.09). No differences at the lumbar spine were observed. ASD are associated with lower bone mass. Future studies should investigate interventions to optimize skeletal health in ASD.
Menninger Department of Psychiatry and Behavioral Science and Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, 1102 Bates Ave, Suite 790, Houston, TX, 77030, USA. chadi.calarge@bcm.edu.
Chadi A
0000-0002-4368-1294
CA
Calarge
Department of Internal Medicine, The University of Iowa Carver College of Medicine, Iowa City, 52242, IA, USA.
Janet A
JA
Schlechte
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008297:Male; D015502:Absorptiometry, Photon / Q000379:methods; D014150:Antipsychotic Agents / Q000627:therapeutic use; D000067877:Autism Spectrum Disorder / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D015519:Bone Density / Q000502:physiology; D003430:Cross-Sectional Studies; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D018967:Risperidone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D064887:Observational Studies as Topic
D014150:Antipsychotic Agents; D018967:Risperidone
Autism; Bone mass; Risperidone