The Effects of Sweet Foods on the Pharmacokinetics of Glycyrrhizic Acid by icELISA.
The effect of sweet foods, such as honey, was investigated from the perspective of pharmacokinetics on the absorption of glycyrrhizic acid (GA). Due to the unique properties of indirect competitive enzyme-linked immunosorbent assay (icELISA), namely, its: specificity, sensitivity, repeatability, simple pretreatment of samples, fast and simple operation, and because it is economic and non-polluting, it has received increased attention. In this study, we used the advantages of this method to see how honey affected the pharmacokinetics of GA. The effects of honey on the pharmacokinetics of GA by ELISA were investigated for the first time. The results indicate that honey can postpone the peak concentration of GA in mouse blood, and this effect correlates well with fructose. As a representative of sweet foods, the result provides the valuable information that honey, or fructose, may act as sustained-releasing drugs in clinical scenarios; and that sweet foods may have some influences on drugs when taken together.
School of Basic Medical Sciences, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China. 20130941016@bucm.edu.cn.
Bingqian
B
Jiang
Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China. quhuihuadr@163.com.
Huihua
H
Qu
School of Basic Medical Sciences, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China. doris7629@126.com.
Hui
H
Kong
School of Basic Medical Sciences, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China. jinzy0423@163.com.
Yue
Y
Zhang
School of Basic Medical Sciences, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China. liushuchensun@163.com.
Shuchen
S
Liu
School of Basic Medical Sciences, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China. carlosjjcheng@163.com.
Jinjun
J
Cheng
School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China. 20150931805@bucm.edu.cn.
Xin
X
Yan
School of Basic Medical Sciences, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China. zhaoyandr@gmail.com.
Yan
Y
Zhao
D000818:Animals; D001774:Blood Chemical Analysis; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005632:Fructose / Q000032:analysis*; D019695:Glycyrrhizic Acid / Q000493:pharmacokinetics*; D006722:Honey / Q000032:analysis*; D051379:Mice; D012680:Sensitivity and Specificity
D005632:Fructose; D019695:Glycyrrhizic Acid
glycyrrhizic acid; icELISA; pharmacokinetics; sweet foods