Nutrient biomarker patterns and long-term risk of dementia in older adults.
BACKGROUND
Several nutrients may predict dementia risk. We characterized nutrient biomarker patterns, which integrate the complexity of nutrient exposure and biodisponibility associated with long-term risk of dementia in a large cohort of older persons, the Three-City study.


METHODS
We included 666 nondemented participants with plasma measurements of 22 fat-soluble nutrients at baseline, who were followed up for 12 years for dementia.


RESULTS
A "deleterious" pattern combining lower blood status in vitamin D, carotenoids, and polyunsaturated fats and higher saturated fats was strongly associated with a higher risk of dementia. Compared with individuals in the first quintile of the pattern score, participants in the highest quintile of score had an approximately fourfold increased risk of dementia (hazard ratio = 4.53 [95% confidence interval 1.99, 10.32], P for trend <.001) in multivariate models.


CONCLUSIONS
A blood pattern reflecting lower status in several nutrients among nondemented individuals appeared strongly associated with the long-term risk of dementia in this cohort.
University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.
Camille
C
Amadieu
University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.
Sophie
S
Lefèvre-Arbogast
University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.
Cécile
C
Delcourt
University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.
Jean-François
JF
Dartigues
University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.
Catherine
C
Helmer
University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.
Catherine
C
Féart
University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France. Electronic address: cecilia.samieri@isped.u-bordeaux2.fr.
Cécilia
C
Samieri
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D002338:Carotenoids / Q000097:blood*; D015331:Cohort Studies; D003704:Dementia / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D015596:Nutrition Assessment; D016016:Proportional Hazards Models; D012307:Risk Factors; D014815:Vitamins / Q000097:blood*
D015415:Biomarkers; D014815:Vitamins; D002338:Carotenoids
Biomarkers; Cohort studies; Dementia; Nutrients; Primary prevention; Risk factors