Genomic resources for the study of neuropsychiatric disorders.
The National Institute of Mental Health (NIMH) has made sustained investments in the development of genomic resources over the last two decades. These investments have led to the development of the largest biorepository for psychiatric genetics as a centralized national resource. In the realm of genomic resources, NIMH has been supporting large team science (TS) consortia focused on gene discovery, fine mapping of loci, and functional genomics using state-of-the-art technologies. The scientific output from these efforts has not only begun to transform our understanding of the genetic architecture of neuropsychiatric disorders, but it has also led to a broader cultural change among the investigator community towards deeper collaborations and broad pre-publication sharing of data and resources. The NIMH supported efforts have led to a vast increase in the amount of genetic and genomic resources available to the mental health research community. Here we provide an account of the existing resources and estimates of the scale and scope of what will be available in the near future. All biosamples and data described are intended for broad sharing with researchers worldwide, as allowed by the subject consent and applicable laws.
Office of Genomics Research Coordination, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
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Senthil
Office of Genomics Research Coordination, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
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Dutka
Office of Genomics Research Coordination, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
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Bingaman
Office of Genomics Research Coordination, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
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Lehner
D003299:Cooperative Behavior; D023281:Genomics / Q000379:methods; D006801:Humans; D033181:Information Dissemination; D020407:Internet; D001523:Mental Disorders / Q000235:genetics* / Q000378:metabolism; D009315:National Institute of Mental Health (U.S.); D014021:Tissue Preservation; D014481:United States