The prognostic value of N-terminal proB-type natriuretic peptide in patients with acute respiratory distress syndrome.
We investigated whether N-terminal proB-type natriuretic peptide (NT-proBNP) predicts the prognosis of patients with acute respiratory distress syndrome (ARDS). Between December 1, 2012, and May 31, 2015, this observational study recruited patients admitted to our tertiary medical center who met the Berlin criteria for ARDS and who had their NT-proBNP measured. The main outcome was 28-day mortality. We enrolled 61 patients who met the Berlin criteria for ARDS: 7 were classified as mild, 29 as moderate, and 25 as severe. The median APACHE II scores were 23 (interquartile range [IQR], 18-28), and SOFA scores were 11 (IQR, 8-13). The median lung injury score was 3.0 (IQR, 2.50-3.25), and the median level of NT-proBNP was 2011 pg/ml (IQR, 579-7216). Thirty-four patients died during this study, and the 28-day mortality rate was 55.7%. Patients who die were older and had significantly (all p < 0.05) higher APACHE II scores and NT-proBNP levels than did patients who survived. Multivariate analysis identified age (HR: 1.546, 95% CI: 1.174-2.035, p = 0.0019) and NT-proBNP (HR: 1.009, 95% CI: 1.004-1.013, p = 0.0001) as significant risk factors of death. NT-proBNP was associated with poor outcomes for patients with ARDS, and its level predicted mortality.
Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Taiwan.
Chih-Cheng
CC
Lai
Departments of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Mei-I
MI
Sung
Departments of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.|Chia Nan University of Pharmacy &Science, Tainan, Taiwan.
Chung-Han
CH
Ho
Departments of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Hsiao-Hua
HH
Liu
Chia Nan University of Pharmacy &Science, Tainan, Taiwan.|Departments of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Chin-Ming
CM
Chen
Departments of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.|Chia Nan University of Pharmacy &Science, Tainan, Taiwan.
Shyh-Ren
SR
Chiang
Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Taiwan.
Chien-Ming
CM
Chao
Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Taiwan.
Wei-Lun
WL
Liu
Departments of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Shu-Chen
SC
Hsing
Departments of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.|Department of Safety Health and Environmental Engineering, Chung Hwa University of Medical Technology, Tainan, Taiwan.
Kuo-Chen
KC
Cheng
D000368:Aged; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D011379:Prognosis; D012372:ROC Curve; D012128:Respiratory Distress Syndrome / Q000175:diagnosis* / Q000401:mortality; D016019:Survival Analysis; D016896:Treatment Outcome
D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain