Positive selection of IL-33 in adaptive immunity of domestic Chinese goats.
The identification of the candidate genes that play key role in phenotypic variation in livestock populations can provide new information about evolution and positive selection. IL-33 (71954) (Interleukin) gene is associated with the increased nematode resistance in small ruminants; however, the role of IL-33 for the genetic control of different diseases in Chinese goat breeds is poorly described in scientific literature. Therefore, the current investigation was performed for the better understanding of the molecular evolution and the positive selection of single-nucleotide polymorphism in IL-33 gene. Fixation Index (FST)-based method was used for the outlier loci determination and found that IL-33 was present in outlier area with the provisional combined allocation of mean heterozygosity andFST. Positively selected IL-33 gene was significantly, that is,p(SimulFST< sampleFST= 0.98*) present in corresponding positive selection area. Hence, our study provided novel information about the nucleotide variations in IL-33 gene and found to be nonsynonymous which may helpful for the genetic control of diseases by enhancing the immune system in local Chinese goat breeds as well as in other analyzed vertebrate species.
Key Lab of Animal Genetics Breeding and Reproduction of Ministry Education College of Animal Science and Technology Huazhong Agricultural University Wuhan China; College of Informatics Huazhong Agricultural University Wuhan China; College of Veterinary & Animal Sciences (CVAS) Jhang Pakistan; University of Veterinary & Animal Sciences Lahore Pakistan.
Akhtar Rasool
0000-0002-2367-9322
AR
Asif
State Key Laboratory of Agricultural Microbiology College of Veterinary Medicine Huazhong Agricultural University Wuhan China.
Muhammad
M
Awais
College of Veterinary & Animal Sciences (CVAS) Jhang Pakistan; University of Veterinary & Animal Sciences Lahore Pakistan.
Sumayyah
S
Qadri
Key Lab of Animal Genetics Breeding and Reproduction of Ministry Education College of Animal Science and Technology Huazhong Agricultural University Wuhan China.
Hafiz Ishfaq
HI
Ahmad
Key Lab of Animal Genetics Breeding and Reproduction of Ministry Education College of Animal Science and Technology Huazhong Agricultural University Wuhan China; College of Informatics Huazhong Agricultural University Wuhan China; The Cooperative Innovation Center for Sustainable Pig Production Wuhan China.
Xiaoyong
X
Du
IL‐33; evolution; goat; positive selection