Exploration of the effect of probiotics supplementation on intestinal microbiota of food allergic mice.
Environmental factor-induced alterations in intestinal microbiota have been demonstrated to be associated with increasing prevalence of food allergy. However, it is not clear to what extent oral administration of probiotics can affect gut microbiota composition, thus inhibiting food allergy development. Using ovalbumin (OVA)-sensitized murine model, it was demonstrated that probiotics ameliorated allergic symptoms, including reducing OVA specific-IgE, and -IgG1 levels in the serum, Th2 cytokines release in spleen, and occurrence of diarrhea. Moreover, 16S rRNA analysis showed that the probiotics-mediated protection was conferred by an enrichment ofCoprococcusandRikenella. The present study supports the theory that probiotics can treat food allergy by modulating specific genera of the gut microbiota.
Institute of Allergy and Immunology, School of Medicine, Shenzhen UniversityShenzhen 518060, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen UniversityShenzhen 518060, China.
Bo
B
Yang
BGI Shenzhen Shenzhen, China.
Liang
L
Xiao
BGI Shenzhen Shenzhen, China.
Sheng
S
Liu
Institute of Allergy and Immunology, School of Medicine, Shenzhen University Shenzhen 518060, China.
Xiaoyu
X
Liu
Institute of Allergy and Immunology, School of Medicine, Shenzhen University Shenzhen 518060, China.
Yan
Y
Luo
Institute of Allergy and Immunology, School of Medicine, Shenzhen University Shenzhen 518060, China.
Qiongmei
Q
Ji
Institute of Allergy and Immunology, School of Medicine, Shenzhen UniversityShenzhen 518060, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen UniversityShenzhen 518060, China.
Pingchang
P
Yang
Institute of Allergy and Immunology, School of Medicine, Shenzhen UniversityShenzhen 518060, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen UniversityShenzhen 518060, China.
Zhigang
Z
Liu
16S rRNA; Intestine; OVA; food allergy; microbiota