[Research progress of mechanism of hypoxia-inducible factor-1α signaling pathway in condylar cartilage growth and remodeling].
The condylar cartilage was adapted to hypoxic conditions in vivo. However, condylar cartilage cells exposed in normoxia in vitro affect the chondrocyte phenotype and cartilage matrix formation. This condition also resulted in great difficulty in chondrocyte research. Culturing chondrocyte should be simulated in in vivo hypoxia environment as much as possible. The hypoxia-inducible factor-1α (HIF-1α) demonstrates an important transcription factor of adaptive response to hypoxic conditions. HIF-1α also plays an active role in maintaining homeostasis and function of chondrocytes. This review summarized current knowledge of the HIF-1α structure, signaling pathway, and mechanism of HIF-1α in the condylar cartilage repair.
School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Xu
X
Gaoli
School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Wu
W
Lili
School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Wu
W
Zhiwu
School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Gu
G
Zhiyuan
D002356:Cartilage; D019902:Chondrocytes; D006801:Humans; D000860:Hypoxia; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D015398:Signal Transduction
D051795:Hypoxia-Inducible Factor 1, alpha Subunit
condylar cartilage; hypoxia-inducible factor-1α; hypoxic; static pressure