Role of Notch signaling pathway in pancreatic cancer.
Pancreatic cancer (PC) is one of the highly aggressive malignancies in the United States. It has been shown that multiple signaling pathways are involved in the pathogenesis of PC, such as JNK, PI3K/AKT, Rho GTPase, Hedgehog (Hh) and Skp2. In recent years, accumulated evidence has demonstrated that Notch signaling pathway plays critical roles in the development and progression of PC. Therefore, in this review we discuss the recent literature regarding the function and regulation of Notch in the pathogenesis of PC. Moreover, we describe that Notch signaling pathway could be down-regulated by its inhibitors or natural compounds, which could be a novel approach for the treatment of PC patients.
Sichuan College of Tranditional Chinese Medicine Mianyang, Sichuan, China.
Jiankun
J
Gao
Department of Infectious Diseases, Mianyang 404 Hospital Mianyang, Sichuan, China.
Bo
B
Long
The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow UniversitySuzhou 215123, China; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolMA 02215, USA.
Zhiwei
Z
Wang
Pancreatic cancer; cellular signaling; notch; target; therapy