The cerebellum shrinks faster than normal ageing in Alzheimer's disease but not in mild cognitive impairment.
While acceleration in age-related cerebral atrophy has been well documented in Alzheimer's disease, the cerebellar contributions to this effect have not been thoroughly investigated.



This study investigated cerebellar volume and atrophy rate using magnetic resonance imaging in individuals with normal cognition (CN), mild cognitive impairment (MCI), and Alzheimer's disease (AD).



Two hundred twenty-nine CN, 398 MCI and 191 AD participants of stage I ADNI database with screening scans were evaluated for cerebellar volume. Of those, 758 individuals with two or more follow-up scans were categorized into stable, converted, and reverted CN, MCI and AD and evaluated for cerebellar atrophy rate.



Cerebellar volume was 2.5% larger in CN than in those with AD but there were no differences between CN and MCI and MCI and AD in cross-sectional analysis. Similarly, the atrophy rate was 49% larger in AD and 64% larger in MCI who converted to AD but no difference was detected between CN and MCI. There were no association between education and APOEe4 and cerebellar volume or cerebellar atrophy across the diagnostic groups.



Cerebellar atrophy contributes to Alzheimer's clinical progression but mostly at the late stage of the disease. However, even in the late stage shrinkage rate is less than the average of the shrinkage in the cerebrum and is not associated with AD moderators. This suggests that cerebellar involvement is secondary to cerebral involvement and can be due to network connection spread regardless of the primary pathology. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc. Hum Brain Mapp 38:3141-3150, 2017. © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. Hum Brain Mapp 38:3141-3150, 2017. © 2017 Wiley Periodicals, Inc.
Centre for Research on Ageing, Health and Wellbeing, The Australian National University, Canberra, Australia.
Hossein
0000-0003-4871-1226
H
Tabatabaei-Jafari
Centre for Research on Ageing, Health and Wellbeing, The Australian National University, Canberra, Australia.
Erin
E
Walsh
Centre for Research on Ageing, Health and Wellbeing, The Australian National University, Canberra, Australia.
Marnie E
ME
Shaw
Centre for Research on Ageing, Health and Wellbeing, The Australian National University, Canberra, Australia.
Nicolas
N
Cherbuin
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000150:complications* / Q000000981:diagnostic imaging; D001284:Atrophy / Q000000981:diagnostic imaging / Q000209:etiology; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000150:complications* / Q000000981:diagnostic imaging; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D018709:Statistics, Nonparametric
Alzheimer's disease; cerebellar atrophy; cerebellum; magnetic resonance imaging; mild cognitive impairment