Stereoselective acetylation of hemicellulosic C5-sugars.
The stereoselective peracetylation of α-d-xylose (1) and α-l-arabinose (4) using a combination of triethylamine and acetic anhydride in the presence or absence of a catalytic amount of dimethylaminopyridine (DMAP) is described. The peracetylated d-xylose and l-arabinose alpha pyranose anomers 2α and 5α are obtained in 97% and 56% yields respectively. The peracetylated d-xylose beta pyranose anomer 2β is obtained in 71% yield through simple modification of the reaction conditions. Details regarding synthesis and isolation optimization studies under different conditions are presented below. The stereoselective peracetylation reactions disclosed here have been used to separate mixtures of d-xylose and l-arabinose as their peracetylated derivatives 2β and 5α in 47% and 42% yields and can provide pure pentoses after deacetylation.
Conn Center for Renewable Energy Research, University of Louisville, Louisville, KY, 40292, USA.
Zachary D
ZD
Herde
Conn Center for Renewable Energy Research, University of Louisville, Louisville, KY, 40292, USA.
Prathap D
PD
John
Conn Center for Renewable Energy Research, University of Louisville, Louisville, KY, 40292, USA.
Dania
D
Alvarez-Fonseca
Conn Center for Renewable Energy Research, University of Louisville, Louisville, KY, 40292, USA.
Jagannadh
J
Satyavolu
Department of Chemistry, University of Louisville, 2320 South Brook Street, Louisville, KY, 40292, USA; Conn Center for Renewable Energy Research, University of Louisville, Louisville, KY, 40292, USA. Electronic address: ctburn02@louisville.edu.
Christopher T
CT
Burns
D000107:Acetylation; D002384:Catalysis; D011134:Polysaccharides / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity; D000073893:Sugars / Q000737:chemistry*
D011134:Polysaccharides; D011725:Pyridines; D000073893:Sugars; C007916:hemicellulose; C023666:pyridine
Acetylation; Arabinose; Carbohydrate; Pentoses; Stereoselective; Xylose