Role of HIF-1α signaling pathway in osteoarthritis: a systematic review.
Osteoarthritis (OA) is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvironment devoid of oxygen, which is regulated by hypoxia inducible factor (HIF-1α). HIF-1α is considered the main transcriptional regulator of cellular and developmental response to hypoxia. To date, the relevance of HIF-1α in the assessment of cartilage has increased since its participation is essential in the homeostasis of this tissue. Taking into account the new emerging insights of HIF-1α in the scientific literature in the last years, we focused the present review on the potential role of HIF-1α signaling pathway in OA development, especially in how some genetic factors may influence the maintenance or breakdown of articular cartilage.
Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Laboratorio de Líquido Sinovial, Mexico City, Mexico; Universidad Autónoma Metropolitana Iztapalapa, Programa de Doctorado de Ciencias Biológicas y de la Salud, Mexico City, Mexico. Electronic address: javier_astrofan@hotmail.com.
Javier
J
Fernández-Torres
Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Laboratorio de Líquido Sinovial, Mexico City, Mexico.
Gabriela Angélica
GA
Martínez-Nava
Universidad Autónoma Metropolitana Iztapalapa, Programa de Doctorado de Ciencias Biológicas y de la Salud, Mexico City, Mexico.
María Concepción
MC
Gutiérrez-Ruíz
Universidad Autónoma Metropolitana Iztapalapa, Programa de Doctorado de Ciencias Biológicas y de la Salud, Mexico City, Mexico.
Luis Enrique
LE
Gómez-Quiroz
Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Laboratorio de Líquido Sinovial, Mexico City, Mexico; Universidad Autónoma Metropolitana Iztapalapa, Programa de Doctorado de Ciencias Biológicas y de la Salud, Mexico City, Mexico.
Marwin
M
Gutiérrez
D002358:Cartilage, Articular / Q000378:metabolism* / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology*; D010003:Osteoarthritis / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction
D051793:Hypoxia-Inducible Factor 1
Fator induzível por hipóxia 1-α; Genetic polymorphisms; HIF-1α signaling pathway; Hypoxia inducible factor-1α; Osteoarthritis; Osteoartrite; Polimorfismos genéticos; Via de sinalização do HIF-1α