A new strategy for accelerated extraction of target compounds using molecularly imprinted polymer particles embedded in a paper-based disk.
In this study, a general simple and inexpensive method is introduced for the preparation of a paper-based selective disk-type solid phase extraction (SPE) technique, appropriate for fast and high throughput monitoring of target compounds. An ion exchange molecularly imprinted polymer (MIP) was synthesized for the extraction and analysis of acesulfame, an anthropogenic water quality marker. Acesulfame imprinting was used as an example for demonstrating the benefits of a nanosized, swellable MIP extraction sorbents integrated in an on-site compatible concept for water quality monitoring. Compared with an 8 mL standard SPE cartridge, the paper-based MIP disk (47 mm ø) format allowed (1) high sample flow rates up to 30 mL•min-1without losing extraction efficiency (2) extracting sample volumes up to 500 mL in much shorter times than with standard SPE, (3) the reuse of the disks (up to 3 times more than SPE cartridge) due to high robustness and an efficient post-cleaning, and (4) reducing the sampling time from 100 minutes (using the standard SPE format) to about 2 minutes with the MIP paper disk for 50 mL water sample. Different parameters like cellulose fiber/polymer ratios, sample volume, sample flow-rate, washing, and elution conditions were evaluated and optimized. Using developed extraction technique with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) analysis, a new protocol was established that provides detection and quantification limits of 0.015 μg•L-1and 0.05 μg•L-1, respectively. The developed paper disks were used in-field for the selective extraction of target compounds and transferred to the laboratory for further analysis.
UFZ-Helmholtz Centre for Environmental Research, Department Monitoring and Exploration Technologies, Leipzig, Germany.
Mashaalah
0000-0002-5346-8067
M
Zarejousheghani
UFZ-Helmholtz Centre for Environmental Research, Department of Analytical Chemistry, Leipzig, Germany.
Steffi
S
Schrader
UFZ-Helmholtz Centre for Environmental Research, Department of Analytical Chemistry, Leipzig, Germany.
Monika
M
Möder
UFZ-Helmholtz Centre for Environmental Research, Department of Isotope Biogeochemistry, ProVIS-Centre for Chemical Microscopy, Leipzig, Germany.
Matthias
M
Schmidt
UFZ-Helmholtz Centre for Environmental Research, Department Monitoring and Exploration Technologies, Leipzig, Germany.
Helko
H
Borsdorf
D002851:Chromatography, High Pressure Liquid; D054802:Molecular Imprinting; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D052616:Solid Phase Extraction; D012997:Solvents / Q000138:chemical synthesis / Q000737:chemistry; D053719:Tandem Mass Spectrometry; D014867:Water / Q000737:chemistry*
D011108:Polymers; D012997:Solvents; D014867:Water
acesulfame; cellulose fiber; filter paper; marker; molecularly imprinted polymer; solid phase extraction disk