Relationship between Depression and Laryngopharyngeal Reflux.
This study investigated the relationship between depression, somatization, anxiety, personality, and laryngopharyngeal reflux (LPR). We prospectively analyzed 231 patients with symptoms with LPR using the laryngopharyngeal reflux symptom index and the reflux finding score. Seventy nine (34.2%) patients were diagnosed with LPR. A significant correlation was detected between the presence of LPR and total scores on the Patient Health Questionnaire-9 (5.6±5.3 vs. 4.0±4.6, p=0.017) and the 7-item Generalized Anxiety Disorder Scale (4.3±4.9 vs. 3.0±4.5, p=0.041). LPR was significantly more frequent in those with depression than in those without (45.6% vs. 27.0%, p=0.004). A multivariate analysis confirmed a significant association between the presence of LPR and depression (odds ratio, 1.068; 95% confidence interval, 1.011-1.128; p=0.019). Our preliminary results suggest that patients with LPR may need to be carefully evaluated for depression.
Department of Otolaryngology-Head & Neck Surgery, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea.
Young-Hoon
YH
Joo
Department of Otolaryngology-Head & Neck Surgery, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea.
Youn-Su
YS
Song
Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea.; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Chi-Un
CU
Pae
Anxiety; Depression; Laryngopharyngeal reflux; Personality; Somatoform disorders