β-Lactoglobulin: An efficient nanocarrier for advanced delivery systems.
Thanks to the progress of nanotechnology there are several agent-delivery systems that can be selected to achieve rapid and specific delivery of a wide variety of biologically active agents. Consequently, the manipulation and engineering of biopolymers has become one of the most exciting subjects for those who study delivery systems on the nanoscale. In this regard, both nanoparticle formation and a carrier role have been observed in the case of the globular milk whey protein, β-lactoglobulin (β-LG), setting it apart from many other proteins. To date, many efforts adopting different approaches have created β-LG nanoparticles useful in forming delivery systems for various agents with specific targets. In this review, the potential of β-LG to play the role of an efficient and diverse carrier protein, as well as its ability to form a well-targeted nano-scale delivery system is discussed.
Department of Cell and Molecular Biology' Faculty of Biological Sciences' Kharazmi University, Tehran, Iran.
Zahra
Z
Shafaei
Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Behafarid
B
Ghalandari
Department of Biotechnology, Faculty of Advanced Science and Technologies of Isfahan, Isfahan, Iran.
Akbar
A
Vaseghi
Department of Cell and Molecular Biology' Faculty of Biological Sciences' Kharazmi University, Tehran, Iran. Electronic address: divsalar@khu.ac.ir.
Adeleh
A
Divsalar
FIP, BIA UR1268, Institut National de la Recherche Agronomique, Nantes, France.
Thomas
T
Haertlé
Institute of Biochemistry and Biophysics' University of Tehran, Tehran, Iran; Center of Excellence in Biothermodynamics, University of Tehran, Tehran, Iran.
Ali Akbar
AA
Saboury
School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
Lindsay
L
Sawyer
D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D007782:Lactoglobulins; D008892:Milk; D008894:Milk Proteins; D053758:Nanoparticles; D000067816:Whey Proteins
D007782:Lactoglobulins; D008894:Milk Proteins; D000067816:Whey Proteins
Delivery system; Nanocarrier; β-LG nanoparticles; β-lactoglobulin