Same same but different: The evolution of TBP in archaea and their eukaryotic offspring.
Transcription factors TBP and TF(II)B assemble with RNA polymerase at the promoter DNA forming the initiation complex. Despite a high degree of conservation, the molecular binding mechanisms of archaeal and eukaryotic TBP and TF(II)B differ significantly. Based on recent biophysical data, we speculate how the mechanisms co-evolved with transcription regulation and TBP multiplicity.
a RNAP Laboratory , University College London, Institute of Structural and Molecular Biology, Division of Biosciences , London , UK.
Fabian
0000-0001-5337-8662
F
Blombach
b Department of Biochemistry, Genetics and Microbiology , Institute of Microbiology, University of Regensburg , Regensburg , Germany.
Dina
D
Grohmann
D001105:Archaea / Q000235:genetics / Q000378:metabolism; D019843:Archaeal Proteins / Q000235:genetics / Q000378:metabolism; D019641:DNA, Archaeal / Q000235:genetics / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D011401:Promoter Regions, Genetic / Q000502:physiology; D035581:Transcription Factor TFIIB / Q000378:metabolism
D019843:Archaeal Proteins; D019641:DNA, Archaeal; D035581:Transcription Factor TFIIB; D012321:DNA-Directed RNA Polymerases
TBP; TFB; archaea; single-molecule FRET; transcription factors; transcription initiation