American Gastroenterological Association Institute Clinical Practice Update-Expert Review: Care of Patients Who Have Achieved a Sustained Virologic Response After Antiviral Therapy for Chronic Hepatitis C Infection.
Chronic hepatitis C virus infection is well-recognized as a common blood-borne infection with global public health impact affecting 3 to 5 million persons in the United States and more than 170 million persons worldwide. Chronic hepatitis C virus infection is associated with significant morbidity and mortality due to complications of liver cirrhosis and hepatocellular carcinoma. Current therapies with all-oral direct-acting antiviral agents are associated with high rates of sustained virologic response (SVR), generally exceeding 90%. SVR is associated with a reduced risk of liver cirrhosis, hepatic decompensation, need for liver transplantation, and both liver-related and all-cause mortality. However, a subset of patients who achieve SVR will remain at long-term risk for progression to cirrhosis, liver failure, hepatocellular carcinoma, and liver-related mortality. Limited evidence is available to guide clinicians on which post-SVR patients should be monitored vs discharged, how to monitor and with which tests, how frequently should monitoring occur, and for how long. In this clinical practice update, available evidence and expert opinion are used to generate best practice recommendations on the care of patients with chronic hepatitis C virus who have achieved SVR.
Department of Medicine, Mount Sinai Beth Israel Medical Center, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: ijacobson@chpnet.org.
Ira M
IM
Jacobson
Section of Digestive Diseases and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut.
Joseph K
JK
Lim
Division of Gastroenterology and Hepatology, UNC Liver Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Michael W
MW
Fried
D000998:Antiviral Agents / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000821:virology; D018450:Disease Progression; D004932:Esophageal and Gastric Varices / Q000175:diagnosis / Q000821:virology; D016174:Hepacivirus; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008103:Liver Cirrhosis / Q000821:virology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000821:virology; D011159:Population Surveillance; D012367:RNA, Viral / Q000097:blood*; D012008:Recurrence; D000072230:Sustained Virologic Response
D000998:Antiviral Agents; D012367:RNA, Viral
Antiviral Therapy; Direct-Acting Antiviral Therapy; Hepatitis C; Hepatocellular Carcinoma; Laboratory Monitoring; Liver Fibrosis; Sustained Virologic Response