FGF23 Is Not Associated With Age-Related Changes in Phosphate, but Enhances Renal Calcium Reabsorption in Girls.
Fibroblast growth factor (FGF)23 is a critical determinant of phosphate homeostasis. The role of FGF23, however, in regulating physiologic changes in serum phosphate and renal phosphate handling across childhood is not well described. In addition, animal models have suggested a role for FGF23 in regulating renal calcium excretion.



To assess changes in FGF23 concentrations across childhood in relation to changes in mineral ions and hormones of mineral ion homeostasis.



This was a cross-sectional study.



The study was conducted at a Clinical Research Center at a tertiary care hospital.



Ninety healthy girls ages 9 to 18 years were recruited from the surrounding community.



The associations of intact and C-terminal FGF23 concentrations with measures of mineral ion homeostasis were determined by univariable and multivariable linear regression.



Serum phosphate and renal phosphate excretion varied with age, as expected (R = -0.49, P < 0.001 and R = -0.48, P < 0.001, respectively). Neither intact nor C-terminal FGF23 varied with age, and FGF23 was not correlated with serum or urinary phosphate. Intact FGF23 was positively correlated with serum calcium (R = 0.39, P < 0.001) and negatively correlated with urinary calcium/creatinine ratio (R = -0.27, P = 0.011).



The changes in serum and urinary phosphate handling across childhood do not appear to be determined by alterations in FGF23 concentrations. These data may point to a role for FGF23 in calcium regulation in human physiology.
Endocrine Unit.|Pediatric Endocrine Unit, and.
Deborah M
DM
Mitchell
Endocrine Unit.|Pediatric Nephrology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114.
Harald
H
Jüppner
Endocrine Unit.
Sherri-Ann M
SM
Burnett-Bowie
D000293:Adolescent; D000367:Age Factors; D002118:Calcium / Q000493:pharmacokinetics*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008903:Minerals / Q000378:metabolism; D010710:Phosphates / Q000097:blood*; D011627:Puberty / Q000378:metabolism; D065608:Renal Reabsorption; D015854:Up-Regulation
C000717427:FGF23 protein, human; D008903:Minerals; D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002118:Calcium