BXD recombinant inbred strains participate in social preference, anxiety and depression behaviors along sex-differences in cytokines and tactile allodynia.
Depression and anxiety are the most common psychiatric disorders, representing a major public health concern. Dysregulation of oxidative and inflammatory systems may be associated with psychiatric disorders, such as depression and anxiety. Due to the need to find appropriate animal models to the understanding of such disorders, we queried whether 2 BXD recombinant inbred (RI) mice strains (BXD21/TyJ RI and BXD84/RwwJ RI mice) and C57BL/6 wild-type mice show differential performance in depression and anxiety related behaviors and biomarkers. Specifically, we assessed social preference, elevated plus maze, forced swim, and Von Frey tests at 3-4 months-of-age, as well as activation of cytokines and antioxidant mRNA levels in the cortex at 7 months-of-age. We report that (1) the BXD84/RwwJ RI strain exhibits anxiety disorder and social avoidance-like behavior (2) BXD21/TyJ RI strain shows a resistance to depression illness, and (3) sex-dependent cytokine profiles and allodynia with elevated inflammatory activity were inherent to male BXD21/TyJ RI mice. In conclusion, we provide novel data in favor of the use of BXD recombinant inbred mice to further understand anxiety and depression disorders.
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Departamento de Psicología y Sociología, Universidad de Zaragoza, Campus Ciudad Escolar, 44003 Teruel, Spain. Electronic address: cgranero@unizar.es.
Caridad
C
López-Granero
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Alessandra
A
Antunes Dos Santos
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Beatriz
B
Ferrer
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Megan
M
Culbreth
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Sudipta
S
Chakraborty
Departamento de Psicología y Sociología, Universidad de Zaragoza, Campus Ciudad Escolar, 44003 Teruel, Spain.
Angel
A
Barrasa
Behavioral Core Facility, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Maria
M
Gulinello
Departments of Pediatrics, Neurology and Biochemistry, Vanderbilt University (VU), and VU Medical Center, Nashville, TN, USA.
Aaron B
AB
Bowman
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: Michael.Aschner@einstein.yu.edu.
Michael
M
Aschner
D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000378:metabolism; D001008:Anxiety Disorders / Q000235:genetics / Q000378:metabolism*; D001522:Behavior, Animal / Q000502:physiology; D015415:Biomarkers; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D003863:Depression / Q000235:genetics / Q000378:metabolism; D003866:Depressive Disorder / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006930:Hyperalgesia / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D012727:Sex Characteristics; D012919:Social Behavior; D012920:Social Behavior Disorders / Q000235:genetics* / Q000378:metabolism
D015415:Biomarkers; D016207:Cytokines
Anxiety; BXD RI mice; Cytokines; Depression; Inflammation; Nrf2