PET-CT evaluation of amyloid systemic involvement with [18F]-florbetaben in patient with proved cardiac amyloidosis: a case report.
One of the most frequent disorders which lead to cardiac amyloidosis is transthyretin-related amyloidosis (ATTR). Some PET radio-pharmaceuticals for the detection of beta-amyloid deposits within the brain have shown to be able to detect also cardiac amyloid deposits. We present a case of a man with ATTR studied with [18F]-florbetaben PET-CT.



Total-body scan showed a moderate uptake in the bone marrow, especially in correspondence of the vertebral column, while no significant myocardial uptake was present. Cardiac-focused scans showed low mean cardiac SUV values confirming the absence of significant myocardial uptake. Brain scan showed a significant cortical brain uptake of the radio-pharmaceutical more evident in correspondence of frontal and temporal lobes.



Distinct subtypes of amyloidosis show different uptake of the radiotracer. Brain amyloid deposition in the presence of a systemic disease could not be caused by the same amyloid precursor.
Nuclear Medicine Unit - Fondazione CNR/Regione Toscana "G. Monasterio", Via Moruzzi 1, 56124, Pisa, Italy. dario.genovesi@ftgm.it.
Dario
D
Genovesi
Cardiovascular Medicine Unit - Fondazione CNR/Regione Toscana "G. Monasterio", Pisa, Italy.
Giuseppe
G
Vergaro
Cardiovascular Medicine Unit - Fondazione CNR/Regione Toscana "G. Monasterio", Pisa, Italy.
Michele
M
Emdin
Nuclear Medicine Unit - Fondazione CNR/Regione Toscana "G. Monasterio", Via Moruzzi 1, 56124, Pisa, Italy.
Assuero
A
Giorgetti
Nuclear Medicine Unit - Fondazione CNR/Regione Toscana "G. Monasterio", Via Moruzzi 1, 56124, Pisa, Italy.
Paolo
P
Marzullo
D000369:Aged, 80 and over; D028227:Amyloid Neuropathies, Familial / Q000000981:diagnostic imaging*; D000814:Aniline Compounds; D009202:Cardiomyopathies / Q000000981:diagnostic imaging*; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D013267:Stilbenes
D000814:Aniline Compounds; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D013267:Stilbenes; C527756:4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene
PET/CT imaging; [18F]-florbetaben; cardiac amyloidosis; radiopharmaceuticals