Microangiopathic antiphospholipid antibody syndrome due to anti-phosphatidylserine/prothrombin complex IgM antibody.
Herein we describe a case of microangiopathic antiphospholipid syndrome (MAPS) due to anti-phosphatidylserine/prothrombin complex (aPS/PT) IgM antibody successfully treated with rituximab. A significant correlation was observed between the clinical course and the aPS/PT IgM antibody titer, which can rise earlier before the appearance of clinical symptoms. Rituximab can be safely and effectively used for MAPS. Although detection of only aPS/PT IgM antibody is rare, aPS/PT IgM antibody might be associated with the pathogenesis of MAPS and might be a useful marker of disease activity.
Department of Pediatrics, Kanazawa Medical Center, National Hospital Organization, Kanazawa, Japan.
Yumi
Y
Senda
Department of Pediatrics, Kanazawa Medical Center, National Hospital Organization, Kanazawa, Japan.
Kazuhide
K
Ohta
Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Tadafumi
T
Yokoyama
Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Masaki
M
Shimizu
Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.
Kengo
K
Furuichi
Department of Nephrology and Laboratory Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Takashi
T
Wada
Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Akihiro
A
Yachie
D016736:Antiphospholipid Syndrome / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D007155:Immunologic Factors / Q000627:therapeutic use*; D010718:Phosphatidylserines / Q000276:immunology*; D011516:Prothrombin / Q000276:immunology*; D000069283:Rituximab / Q000627:therapeutic use*
D001323:Autoantibodies; D015415:Biomarkers; D007075:Immunoglobulin M; D007155:Immunologic Factors; D010718:Phosphatidylserines; D000069283:Rituximab; D011516:Prothrombin
anti-phosphatidylserine/prothrombin complex IgM antibody; microangiopathic antiphospholipid antibody syndrome; rituximab