Effect of an Anterior Cingulotomy on Pain, Cognition, and Sensory Pathways.
BACKGROUND
Anterior cingulotomy (AC) was originally used to treat patients with a psychiatric disorder, but it is also useful for treating patients with chronic intractable pain. We reviewed 24 patients at our hospital who underwent AC for chronic intractable pain to determine whether surgery influenced patient cognition and the pain circuit.


METHODS
A visual analog scale (VAS) was used to evaluate patients' pain scale preoperatively, at 1 month and 3-6 months postoperatively, and at the final follow-up. Mini-Mental State Examination (MMSE) and Cognitive Abilities Screening Instrument (CASI) were used to evaluate postoperative cognitive function. The latencies of peaks P20 and P37 of the somatosensory evoked potential (SSEP) conductive time were used to evaluate the intactness of the thalamocortical tract after AC.


RESULTS
The median preoperative VAS score was 8, MMSE score was 27, and CASI score was 86.8. Six patients underwent a reoperation because of recurrent pain. Pain was significantly reduced after AC, and the median VAS score at the last follow-up was 5. There was no significant pain improvement in patients who underwent a reoperation. There were no significant changes in MMSE and CASI scores or SSEP after cingulotomy. There were no operation-related complications in the patients.


CONCLUSIONS
A stereotactic AC was safe and effective in resolving chronic refractory pain. It did not affect patient cognition or the sensory conductive pathway. However, patients who had recurrent intractable pain after a cingulotomy did not respond well to the reoperation.
Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Guan-Chyuan
GC
Wang
Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Tomor
T
Harnod
Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Tsung-Lang
TL
Chiu
Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. Electronic address: alumb.tw@yahoo.com.tw.
Kuan-Pin
KP
Chen
D000328:Adult; D000368:Aged; D003071:Cognition / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D006179:Gyrus Cinguli / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000502:physiology; D010147:Pain Measurement; D010148:Intractable Pain / Q000503:physiopathology / Q000601:surgery*; D011930:Reaction Time; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
Cingulotomy; Cognition; Pain