Increased nucleus accumbens volume in first-episode psychosis.
Nucleus accumbens has been reported as a key structure in the neurobiology of schizophrenia. Studies analyzing structural abnormalities have shown conflicting results, possibly related to confounding factors. We investigated the nucleus accumbens volume using manual delimitation in first-episode psychosis (FEP) controlling for age, cannabis use and medication. Thirty-one FEP subjects who were naive or minimally exposed to antipsychotics and a control group were MRI scanned and clinically assessed from baseline to 6 months of follow-up. FEP showed increased relative and total accumbens volumes. Clinical correlations with negative symptoms, duration of untreated psychosis and cannabis use were not significant.
Department of Cognitive Neuroscience and Information Technologies, Internet Interdisciplinary Institute, Open University of Catalonia, Barcelona, Spain.
Mireia
M
Forns-Nadal
Neuroscience group, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; Departament de Psiquiatria i Medicina Legal, Facultat de Medicina, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, Spain; CIBERSAM, Barcelona, Spain. Electronic address: dbergeba@gmail.com.
Daniel
D
Bergé
Department of Applied Mathematics and Analysis of the University of Barcelona, Barcelona, Spain.
Federico
F
Sem
Neuroscience group, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; CIBERSAM, Barcelona, Spain.
Anna
A
Mané
Department of Applied Mathematics and Analysis of the University of Barcelona, Barcelona, Spain; Computer Vision Center, Edificio O, Universitat Autònoma de Barcelona, Campus de Bellaterra, s/n, Cerdanyola del Vallès, Spain.
Laura
L
Igual
Neuroscience group, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; Departament de Psiquiatria i Medicina Legal, Facultat de Medicina, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, Spain.
Dani
D
Guinart
Neuroscience group, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; Departament de Psiquiatria i Medicina Legal, Facultat de Medicina, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, Spain.
Oscar
O
Vilarroya
D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009714:Nucleus Accumbens / Q000000981:diagnostic imaging* / Q000473:pathology; D009929:Organ Size; D011618:Psychotic Disorders / Q000000981:diagnostic imaging* / Q000473:pathology / Q000523:psychology*
Neuroimaging; Region of interest; Reward; Schizophrenia