Elevated red blood cell distribution width is associated with intrahepatic cholestasis of pregnancy.
Intrahepatic cholestasis of pregnancy is the most common pregnancy specific liver disease and related with adverse maternal and perinatal outcome. Red blood cell distribution width, an anisocytosis marker in a complete blood count, has been used as an inflammation marker in various diseases. However the association of red blood cell distribution width with intrahepatic cholestasis of pregnancy is unknown. We aimed to evaluate the relationship between red blood cell distribution width and intrahepatic cholestasis of pregnancy.



Ninety pregnant women with intrahepatic cholestasis of pregnancy and ninety healthy pregnant women were included in the study. Their clinical and laboratory characteristics including red blood cell distribution width, liver function tests, fasting and postprandial bile acid concentrations were analyzed.



Serum red blood cell distribution width cell levels were significantly higher in pregnants with intrahepatic cholestasis of pregnancy than healthy pregnants. We also demonstrated that red blood cell distribution Width levels were higher in severe disease than mild disease and was significantly correlated with fasting and postprandial bile acid concentration in intrahepatic cholestasis of pregnancy group.



Our study showed that red blood cell distribution width, an easy and inexpensive marker; were associated with intrahepatic cholestasis of pregnancy and can be used as a diagnostic and prognostic marker in intrahepatic cholestasis of pregnancy.
Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey. zehravural@gmail.com.
Zehra
Z
Vural Yilmaz
Gulenay
G
Gencosmanoglu Turkmen
Korkut
K
Daglar
Elif
E
Yılmaz
Ozgur
O
Kara
Dilek
D
Uygur
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001647:Bile Acids and Salts / Q000097:blood; D016022:Case-Control Studies; D002780:Cholestasis, Intrahepatic / Q000097:blood*; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D012720:Severity of Illness Index; D055815:Young Adult
D001647:Bile Acids and Salts; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
intrahepatic cholestasis of pregnancy; red blood cell distribution width; severity