Tensin links energy metabolism to extracellular matrix assembly.
The regulation of integrin function is key to fundamental cellular processes, including cell migration and extracellular matrix (ECM) assembly. In this issue, Georgiadou et al. (2017.J. Cell Biol.https://doi.org/10.1083/jcb.201609066) report that the metabolic sensor adenosine monophosphate-activated protein kinase influences tensin production to regulate α5β1-integrin and fibrillar adhesion assembly and thus reveal an important connection between energy metabolism and ECM assembly.
Cancer Research UK Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland, UK.
Emmanuel
E
Dornier
Cancer Research UK Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland, UK.|Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, Scotland, UK.
Jim C
0000-0002-0098-3014
JC
Norman
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D039081:Integrin alpha5beta1 / Q000378:metabolism; D000070876:Tensins / Q000378:metabolism*
D039081:Integrin alpha5beta1; D000070876:Tensins