Double-Edged Sword: Musculoskeletal Infection Provoked Acute Phase Response in Children.
The acute phase response has a crucial role in mounting the body's response to tissue injury. Excessive activation of the acute phase response is responsible for many complications that occur in orthopedic patients. Given that infection may be considered continuous tissue injury that persistently activates the acute phase response, children with musculoskeletal infections are at markedly increased risk for serious complications. Future strategies that modulate the acute phase response have the potential to improve treatment and prevent complications associated with musculoskeletal infection.
Vanderbilt University School of Medicine, Nashville, TN, USA.
Michael
M
Benvenuti
Vanderbilt University School of Medicine, Nashville, TN, USA.
Thomas
T
An
Vanderbilt University School of Medicine, Nashville, TN, USA.
Emilie
E
Amaro
Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, TN, USA.
Steven
S
Lovejoy
Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, TN, USA.
Gregory
G
Mencio
Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, TN, USA.
Jeffrey
J
Martus
Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, TN, USA.
Megan
M
Mignemi
Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, TN, USA; Departments of Orthopaedics, Pharmacology, and Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: jon.schoenecker@vanderbilt.edu.
Jonathan G
JG
Schoenecker
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000210:Acute-Phase Reaction / Q000209:etiology / Q000378:metabolism; D001170:Arthritis, Infectious / Q000150:complications / Q000175:diagnosis / Q000378:metabolism; D002648:Child; D006801:Humans; D008660:Metabolism; D010019:Osteomyelitis / Q000150:complications / Q000175:diagnosis / Q000378:metabolism; D052880:Pyomyositis / Q000150:complications / Q000175:diagnosis / Q000378:metabolism
D000209:Acute-Phase Proteins
Acute phase response; Musculoskeletal infection; Osteomyelitis; Pyomyositis; Septic arthritis