Polysaccharide based bionanocomposite hydrogels reinforced with cellulose nanocrystals: Drug release and biocompatibility analyses.
Cellulose nanocrystals (CNCs) reinforced, bionanocomposite (BNC) has shown great potential in tissue engineering and drug delivery applications due to the low toxicity, low density, and high aspect ratio. In this work, BNC hydrogels reinforced with CNCs were fabricated from xanthan (XG) solutions and chitosan (CS) in presence of green acidifying agent through electrostatic and hydrogen bonding interactions. As developed BNC hydrogels were characterized for complex formation, morphology, and mechanical behavior. The mechanical performance of BNC hydrogels was improved significantly as increased CNC content (from 2 to 10wt%). 5-Flurouracil as model chemotherapeutic agent was loaded into these BNC hydrogels for evaluating their drug release properties. The BNC hydrogels showed excellent cytocompatability and ability to release of chemotherapeutic agent that shows the suitability to be used in tissue engineering as well as drug delivery applications.
School of Chemical Engineering, Yeungnam University, 280-Daehak-Ro, Gyeongsan 712-749, South Korea. Electronic address: msraochem@yu.ac.kr.
Kummara
K
Madhusudana Rao
School of Chemical Engineering, Yeungnam University, 280-Daehak-Ro, Gyeongsan 712-749, South Korea.
Anuj
A
Kumar
School of Chemical Engineering, Yeungnam University, 280-Daehak-Ro, Gyeongsan 712-749, South Korea. Electronic address: sshan3892@gmail.com.
Sung Soo
SS
Han
D000818:Animals; D002482:Cellulose / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D065546:Drug Liberation; D005472:Fluorouracil / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry
D004337:Drug Carriers; D020100:Hydrogels; D011135:Polysaccharides, Bacterial; D002482:Cellulose; D048271:Chitosan; C002563:xanthan gum; D005472:Fluorouracil
Biocompatibility; Bionanocomposite; Cellulose nanocrystals; Drug release; Hydrogels