Infectious complications in patients with myelodysplastic syndromes: A review of the literature with emphasis on patients treated with 5-azacitidine.
Myelodysplastic Syndromes are oligo-clonal stem cell disorders that are associated with cytopenias in the peripheral blood. Major causes for morbidity and mortality in myelodysplastic syndromes (MDS) patients are infections mostly due to bacteria or fungi. Beside leucopenia per se in affected patients, function of white blood cells particularly that of neutrophils seems to be impaired. Here we summarize the available data on infections in MDS patients in general and particularly those treated with 5-azacitidine.
3rd Department of Medicine, Johannes Gutenberg University Medical Center, Mainz, Germany.
Markus
M
Radsak
Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Uwe
U
Platzbecker
3rd Department of Medicine, Johannes Gutenberg University Medical Center, Mainz, Germany.
Cornelia S
CS
Schmidt
Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany.
Wolf-Karsten
WK
Hofmann
Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany.
Florian
http://orcid.org/0000-0002-2765-8940
F
Nolte
D019072:Antibiotic Prophylaxis; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D001374:Azacitidine / Q000009:adverse effects* / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D017053:Infection Control; D007239:Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D009017:Morbidity; D009026:Mortality; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000188:drug therapy; D009503:Neutropenia / Q000150:complications / Q000209:etiology
D000964:Antimetabolites, Antineoplastic; D016179:Granulocyte Colony-Stimulating Factor; D001374:Azacitidine
5-azacitidine; infection; myelodysplastic syndromes; socioeconomics and ethics; supportive care