Self-reported sleep disturbances associated with procedural learning impairment in adolescents at ultra-high risk for psychosis.
Sleep disturbance contributes to impaired procedural learning in schizophrenia, yet little is known about this relationship prior to psychosis onset. Adolescents at ultra high-risk (UHR; N=62) for psychosis completed the Pittsburgh Sleep Quality Index (PSQI) and a procedural learning task (Pursuit Rotor). Increased self-reported problems with sleep latency, efficiency, and quality were associated with impaired procedural learning rate. Further, within-sample comparisons revealed that UHR youth reporting better sleep displayed a steeper learning curve than those with poorer sleep. Sleep disturbances appear to contribute to cognitive/motor deficits in the UHR period and may play a role in psychosis etiology.
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States. Electronic address: jessica.r.avery@duke.edu.
Jessica R
JR
Lunsford-Avery
Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States.
Derek J
DJ
Dean
Department of Psychology, Northwestern University, Evanston, IL, United States.
Vijay A
VA
Mittal
D000293:Adolescent; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D007858:Learning; D007859:Learning Disabilities / Q000150:complications*; D008297:Male; D009483:Neuropsychological Tests; D062706:Prodromal Symptoms; D011618:Psychotic Disorders / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D012306:Risk; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D057566:Self Report; D012890:Sleep; D012893:Sleep Wake Disorders / Q000150:complications* / Q000523:psychology; D055815:Young Adult
Procedural learning; Prodromal; Psychosis; Schizophrenia; Sleep; Ultra high-risk