Genetic Analysis of FBXO2, FBXO6, FBXO12, and FBXO41 Variants in Han Chinese Patients with Sporadic Parkinson's Disease.
Parkinson's disease (PD) is the second most common neurodegenerative disorder and has an elusive etiology. It is likely multifactorial, and genetic defects contribute to its pathogenesis. At least 25 genetic loci and 20 monogenic genes have been identified in monogenic PD. Recessive F-box protein 7 gene (FBXO7) mutations reportedly cause hereditary parkinsonism. To explore the roles of four paralogs (FBXO2, FBXO6, FBXO12, and FBXO41) in PD development, their variants (rs9614, rs28924120, rs6442117, and rs61733550, respectively) were analyzed in 502 Han Chinese patients with PD and 556 age, gender, and ethnicity-matched normal participants in mainland China. Statistically significant differences in genotypic and allelic frequencies were detected only in the FBXO2 variant rs9614 (P = 0.001 and 0.023, respectively; odds ratio 0.819, 95% confidence interval 0.690-0.973) between patients and controls. These results suggest that the FBXO2 variant rs9614 C allele may decrease the PD risk in mainland Han Chinese and may be a biomarker for PD.
Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.|Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Lamei
L
Yuan
Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Zhi
Z
Song
Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Xiong
X
Deng
Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Zhijian
Z
Yang
Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Yan
Y
Yang
Department of Medical Information, Information Security and Big Data Research Institute, Central South University, Changsha, 410013, China.
Yi
Y
Guo
Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. hwlv2226@163.com.
Hongwei
H
Lu
Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. hdeng008@yahoo.com.|Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. hdeng008@yahoo.com.
Hao
H
Deng
D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics; D044783:F-Box Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010300:Parkinson Disease / Q000235:genetics*
D044783:F-Box Proteins
FBXO12; FBXO2; FBXO41; FBXO6; Parkinson’s disease; Variant