Skin Tissue Engineering: Application of Adipose-Derived Stem Cells.
Perception of the adipose tissue has changed dramatically over the last few decades. Identification of adipose-derived stem cells (ASCs) ultimately transformed paradigm of this tissue from a passive energy depot into a promising stem cell source with properties of self-renewal and multipotential differentiation. As compared to bone marrow-derived stem cells (BMSCs), ASCs are more easily accessible and their isolation yields higher amount of stem cells. Therefore, the ASCs are of high interest for stem cell-based therapies and skin tissue engineering. Currently, freshly isolated stromal vascular fraction (SVF), which may be used directly without any expansion, was also assessed to be highly effective in treating skin radiation injuries, burns, or nonhealing wounds such as diabetic ulcers. In this paper, we review the characteristics of SVF and ASCs and the efficacy of their treatment for skin injuries and disorders.
University Children's Hospital Zurich, Tissue Biology Research Unit, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Agnes S
0000-0003-3521-8010
AS
Klar
University Children's Hospital Zurich, Tissue Biology Research Unit, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Jakub
J
Zimoch
University Children's Hospital Zurich, Tissue Biology Research Unit, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Thomas
T
Biedermann
D017667:Adipocytes / Q000166:cytology; D000273:Adipose Tissue / Q000166:cytology / Q000254:growth & development*; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation / Q000235:genetics; D006801:Humans; D059630:Mesenchymal Stem Cells; D012867:Skin / Q000166:cytology / Q000254:growth & development*; D033581:Stem Cell Transplantation; D023822:Tissue Engineering