Electrochemically stimulated drug release from flexible electrodes coated electrophoretically with doxorubicin loaded reduced graphene oxide.
The electrochemically triggered release of doxorubicin (DOX) from flexible electrodes modified electrophoretically with reduced graphene oxide (rGO)-DOX is reported. The release is driven by a positive potential pulse that decreases the pH of the rGO-DOX surface locally, which is confirmed by scanning electrochemical microscopy (SECM) in situ. In vitro cell viability tests confirms that the delivery system meets therapeutic needs.
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel. daniel.mandler@mail.huji.ac.il.
Lijie
L
He
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel. daniel.mandler@mail.huji.ac.il.
Sujoy
http://orcid.org/0000-0001-7838-0005
S
Sarkar
Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, UMR 8520 - IEMN, F-59000 Lille, France.
Alexandre
A
Barras
Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, UMR 8520 - IEMN, F-59000 Lille, France.
Rabah
http://orcid.org/0000-0002-9795-9888
R
Boukherroub
Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, UMR 8520 - IEMN, F-59000 Lille, France.
Sabine
http://orcid.org/0000-0002-1567-4943
S
Szunerits
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel. daniel.mandler@mail.huji.ac.il.
Daniel
http://orcid.org/0000-0003-2490-1084
D
Mandler