Inactivation of dermatophyte infection by nonthermal plasma on animal model.
Superficial fungal infections are a major epidemiological issue with increasing prevalence and are a common global problem. This article describes experimental therapy of superficial fungal skin infection using low-temperature plasma. Groups of guinea pigs were artificially infected with Trichophyton mentagrophytes SK 3286 dermatophyte and treated with plasma produced by a DC cometary discharge with an inserted grid. The course of infection was a week shorter and milder in animals treated by plasma than that in nontreated animals, the significant lowering of dermatophytic germs also occurred in the treated group. The exposure to plasma causes no harm to experimental animals. The results allow for the development of a new dermatophytoses therapy by low temperature plasma treatment.
Department of Physics and Measurements, University of Chemistry and Technology, Prague, Czech Republic.
Vladimír
V
Scholtz
Department of Computing and Control Engineering, University of Chemistry and Technology, Prague, Czech Republic.
Hana
H
Soušková
Department of Computing and Control Engineering, University of Chemistry and Technology, Prague, Czech Republic.
Michaela
M
Švarcová
Department of Physics, Faculty of Electrical Engineering, Czech Technical University in Prague, Czech Republic.
Vítezslav
V
Kríha
Radio-Isotope Laboratory and Vivarium, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Czech Republic.
Helena
H
Živná
Institute of Immunology and Microbiology, 1st Faculty of Medicine, Charles University in Prague, Czech Republic.
Jaroslav
J
Julák
D000287:Administration, Topical; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000628:therapy*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D008297:Male; D058626:Plasma Gases / Q000627:therapeutic use*; D016896:Treatment Outcome; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D058626:Plasma Gases
Trichophyton; cometary discharge; dermatophytosis; guinea pig; skin mycosis