Expression of Activating Protein 4 and Its Relationships with Prognosis in Gastric Cancer.
OBJECTIVE
The aim of this work was to investigate the expression of transcription activating protein 4 (AP-4) in gastric cancer (GC) and its impacts on prognosis.


METHODS
The cancer tissues and normal tissues of 54 GC patients were sampled for the expression detection of AP-4, and the patients were followed up.


RESULTS
The positive expression rate of AP-4 in the cancer tissues (68.5%) was higher than the normal tissues (22.2%; p < 0.01). The lower the tumor differentiation degree and the deeper the invasion depth, the higher the expression rate of AP-4. The median survival time of the patients with positive AP-4 expression was significantly shorter than of those without AP-4 expression (26.3/41.3 months), and the accumulative survival rate of the former was also lower than the latter (χ2 = 4.736, p = 0.03). AP-4 was expressed in GC tissues and normal gastric tissues, with the expression in the former being higher.


CONCLUSIONS
The expression of AP-4 was positively related with the tumor differentiation degree, invasion depth, lymph node metastasis, and pTNM stage, while it was not related with patient gender, age, tumor size, location, or distant metastasis. AP-4 might be used as an indicator for the prognosis prediction of GC.
Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Xiuwei
X
Sun
Zhanjun
Z
Feng
Yao
Y
Qu
Jiayue
J
Shao
Ning
N
Wei
D000328:Adult; D000368:Aged; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; C055473:enhancer-binding protein AP-4