Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation.
Hair loss known as alopecia is caused by abnormal hair follicle cycling including shortening of the anagen (growth) phase and changing of hair follicle morphology with miniaturization. In accordance with the life extension, the quality of life is considered to be a most important thing. The yearning for healthy and beautiful hair and low self esteem due to hair loss had negative influence on the quality of life with psychosocial maladjustment. The objective of this research was to identify new compound that can be used as a drug to promote hair growth. We investigated whether the function of sinapic acid (SA) is able to promote hair growth in human hair follicle dermal papilla cells (hHFDPC). We showed that treatment of SA in hHFDPC could induce proliferation and the activation of Akt signaling in HFDPC. In addition, SA could stimulate the expressions of the several growth factors, insulin-like growth factor 1, and vascular endothelial growth factor for hair growth. We showed that SA led to an increased level of phospho-GSK-3β and β-catenin accumulation in HFDPC. Finally, the promoting effect of SA in hHFDPC cell growth occurred by the induction of cell cycle progression. These results suggest that SA could be one of the potential candidate compounds for the treatment of alopecia by inducing hair growth through triggering the expressions of growth factors via activation of Akt and subsequent inactivation of GSK-3β /β-catenin pathway.
Biospectrum Life Science Institute, Eines Platz 11th FL, #442-13 Sangdeawon-dong, Seongnam-si, Gyeonggi-do, Republic of Korea.
Hyunju
H
Woo
Biospectrum Life Science Institute, Eines Platz 11th FL, #442-13 Sangdeawon-dong, Seongnam-si, Gyeonggi-do, Republic of Korea.
Seungjun
S
Lee
Biospectrum Life Science Institute, Eines Platz 11th FL, #442-13 Sangdeawon-dong, Seongnam-si, Gyeonggi-do, Republic of Korea.
Seungbeom
S
Kim
Biospectrum Life Science Institute, Eines Platz 11th FL, #442-13 Sangdeawon-dong, Seongnam-si, Gyeonggi-do, Republic of Korea.
Deokhoon
D
Park
Biospectrum Life Science Institute, Eines Platz 11th FL, #442-13 Sangdeawon-dong, Seongnam-si, Gyeonggi-do, Republic of Korea. bioso@biospectrum.com.
Eunsun
E
Jung
D000505:Alopecia / Q000188:drug therapy* / Q000517:prevention & control; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003373:Coumaric Acids / Q000494:pharmacology*; D000071679:Glycogen Synthase Kinase 3 beta / Q000378:metabolism; D018859:Hair Follicle / Q000166:cytology / Q000254:growth & development*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011788:Quality of Life; D015398:Signal Transduction / Q000187:drug effects; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis; D060449:Wnt Signaling Pathway / Q000187:drug effects*; D051176:beta Catenin / Q000378:metabolism
C495270:CTNNB1 protein, human; D003373:Coumaric Acids; C583557:IGF1 protein, human; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D051176:beta Catenin; D007334:Insulin-Like Growth Factor I; C073734:sinapinic acid; D000071679:Glycogen Synthase Kinase 3 beta; D051057:Proto-Oncogene Proteins c-akt
Hair growth; Human hair follicle derma papilla cells; Sinapic acid; Wnt/β-catenin signaling pathway