The Role of PIAS SUMO E3-Ligases in Cancer.
SUMOylation modifies the interactome, localization, activity, and lifespan of its target proteins. This process regulates several cellular machineries, including transcription, DNA damage repair, cell-cycle progression, and apoptosis. Accordingly, SUMOylation is critical in maintaining cellular homeostasis, and its deregulation leads to the corruption of a plethora of cellular processes that contribute to disease states. Among the proteins involved in SUMOylation, the protein inhibitor of activated STAT (PIAS) E3-ligases were initially described as transcriptional coregulators. Recent findings also indicate that they have a role in regulating protein stability and signaling transduction pathways. PIAS proteins interact with up to 60 cellular partners affecting several cellular processes, most notably immune regulation and DNA repair, but also cellular proliferation and survival. Here, we summarize the current knowledge about their role in tumorigenesis and cancer-related processes.Cancer Res; 77(7); 1542-7. ©2017 AACR.
Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas.|Simmons Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas.|QIMR Berghofer Medical Research Institute, Brisbane City, Queensland, Australia.
Andrea
A
Rabellino
Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas.|Simmons Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas.
Cristina
C
Andreani
Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas. Pier.Scaglioni@utsouthwestern.edu.|Simmons Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas.
Pier Paolo
PP
Scaglioni
D000818:Animals; D002465:Cell Movement; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D050828:Protein Inhibitors of Activated STAT / Q000502:physiology*; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology; D058207:Sumoylation; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D044767:Ubiquitin-Protein Ligases / Q000502:physiology*
C489427:MYC protein, human; D050828:Protein Inhibitors of Activated STAT; D016271:Proto-Oncogene Proteins c-myc; D016159:Tumor Suppressor Protein p53; D044767:Ubiquitin-Protein Ligases; D019869:Phosphatidylinositol 3-Kinases