Three new isobenzofurans from the roots of Nicotiana Tabacum and their bioactivities.
Three new isobenzofurans (1-3), together with four known phenylpropanoids (4-7) were isolated from the roots of Nicotiana tabacum. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-6 were tested for their anti-tobacco mosaic virus (anti-TMV) activities and cytotoxicity activities. The results showed that compounds 5 and 6 exhibited high anti-TMV activities with inhibition rates of 35.1 and 33.4%, respectively. The cytotoxicities of compounds 1-7 against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 were also tested. Compounds 1-7 showed weak inhibitory activities against some tested human tumor cell lines with IC50values in the range of 3.8-9.6 μM.
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China tobacco yunnan industrial Co., Ltd , Kunming , P.R. China.
Pei
P
He
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China tobacco yunnan industrial Co., Ltd , Kunming , P.R. China.|b School of Chemical Science and Technology , Yunnan University , Kunming , P.R. China.
Peisong
P
Yang
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China tobacco yunnan industrial Co., Ltd , Kunming , P.R. China.
Shiyun
S
Tang
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China tobacco yunnan industrial Co., Ltd , Kunming , P.R. China.
Ling
L
Ye
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China tobacco yunnan industrial Co., Ltd , Kunming , P.R. China.
Chunbo
C
Liu
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China tobacco yunnan industrial Co., Ltd , Kunming , P.R. China.
Qinpeng
Q
Shen
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China tobacco yunnan industrial Co., Ltd , Kunming , P.R. China.
Dangyu
D
Tang
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China tobacco yunnan industrial Co., Ltd , Kunming , P.R. China.
Fengmei
F
Zhang
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China tobacco yunnan industrial Co., Ltd , Kunming , P.R. China.
Zhihua
Z
Liu
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China tobacco yunnan industrial Co., Ltd , Kunming , P.R. China.
Yongkuan
Y
Chen
c State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha , P.R. China.
Shouzhuo
S
Yao
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China tobacco yunnan industrial Co., Ltd , Kunming , P.R. China.
Nengjun
N
Xiang
b School of Chemical Science and Technology , Yunnan University , Kunming , P.R. China.
Zhangjie
Z
Huang
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D014026:Nicotiana / Q000737:chemistry*; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D001572:Benzofurans
Isobenzofurans; Nicotiana tabacum; anti-tobacco mosaic virus activity; cytotoxicity