The impact of rifaximin in the prevention of bacterial infections in cirrhosis.
Bacterial infections are a leading factor in the progression from compensated to decompensated cirrhosis, with consequent worsening of the prognosis, and concerted efforts have been made to reduce infections and improve the survival rate of these patients. We retrospectively investigated the rate of infections in hospitalized cirrhotic patients under treatment with rifaximin.



We enrolled 649 patients whose clinical and personal data, prescribed therapy, microbiological findings and laboratory tests were collected from previous discharge letters and our institution database. The efficacy of rifaximin in preventing several types infection was evaluated by comparing outcomes for rifaximin-treated patients vs patients receiving no antibiotic treatment.



The risk of developing selected bacterial infections was significantly lower in patients treated with rifaximin (OR 0.29; 95% CI 0.20-0.40, p < 0.001).



Continuous treatment with rifaximin may prevent bacterial infections in cirrhotic patients.
Department of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. raffaele.bruno@unipv.it.
M
M
Mariani
V
V
Zuccaro
S F A
SF
Patruno
L
L
Scudeller
P
P
Sacchi
A
A
Lombardi
M
M
Vecchia
P
P
Columpsi
P
P
Marone
G
G
Filice
R
R
Bruno
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000150:complications / Q000517:prevention & control*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D012294:Rifamycins / Q000627:therapeutic use*; D000078262:Rifaximin; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D012294:Rifamycins; D000078262:Rifaximin