A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions.
Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes.
Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Rd, Lucas Heights, New South Wales, Australia.|Department of Chemistry, Curtin University, Kent St, Bentley, Western Australia, Australia.
Mitchell A
http://orcid.org/0000-0003-0099-4984
MA
Klenner
Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Rd, Lucas Heights, New South Wales, Australia.|Brain and Mind Centre, The University of Sydney, Mallett St, Camperdown, New South Wales, Australia.
Giancarlo
http://orcid.org/0000-0001-7919-8416
G
Pascali
Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Rd, Lucas Heights, New South Wales, Australia.|Monash University, Wellington Road, Clayton, Victoria, Australia.
Bo
B
Zhang
Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Rd, Lucas Heights, New South Wales, Australia.|Brain and Mind Centre, The University of Sydney, Mallett St, Camperdown, New South Wales, Australia.
Tiffany R
TR
Sia
School of Science and Health, Western Sydney University, Penrith, New South Wales, Australia.
Lawson K
LK
Spare
Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Rd, Lucas Heights, New South Wales, Australia.
Anwen M
AM
Krause-Heuer
School of Science and Health, Western Sydney University, Penrith, New South Wales, Australia.
Janice R
JR
Aldrich-Wright
Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Rd, Lucas Heights, New South Wales, Australia.
Ivan
I
Greguric
Brain and Mind Centre, The University of Sydney, Mallett St, Camperdown, New South Wales, Australia.
Adam J
AJ
Guastella
Department of Chemistry, Curtin University, Kent St, Bentley, Western Australia, Australia.
Massimiliano
M
Massi
Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Rd, Lucas Heights, New South Wales, Australia.
Benjamin H
BH
Fraser
fluorine-18 radiolabeling; late-stage fluorination; microfluidics; pet chemistry; rhenium complexes