TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.
Mascarenhas et al. report that TRPV4 expression is upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates mast cell degranulation. These findings render TRPV4 a translational-medical target in rosacea. However, signaling mechanisms causing increased expression of TRPV4 await elucidation. Moreover, we ask whether TRPV4-mediated Ca++-influx evokes mast cell degranulation.
Department of Neurology, Duke University, School of Medicine, Durham, North Carolina, USA.
Yong
Y
Chen
Department of Neurology, Duke University, School of Medicine, Durham, North Carolina, USA.
Carlene D
CD
Moore
Department of Dermatology, Duke University, Durham, North Carolina, USA.
Jennifer Y
JY
Zhang
Department of Dermatology, Duke University, Durham, North Carolina, USA.
Russell P
RP
Hall
Department of Dermatology, Duke University, Durham, North Carolina, USA.
Amanda S
AS
MacLeod
Department of Neurology, Duke University, School of Medicine, Durham, North Carolina, USA; Department of Anesthesiology, Duke University, School of Medicine, Durham, North Carolina, USA; Department of Neurobiology, Duke University, School of Medicine, Durham, North Carolina, USA. Electronic address: liedt001@duke.edu.
Wolfgang
W
Liedtke
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D020013:Calcium Signaling / Q000235:genetics; D002478:Cells, Cultured / Q000166:cytology / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D008407:Mast Cells / Q000166:cytology / Q000502:physiology; D051379:Mice; D012393:Rosacea / Q000235:genetics* / Q000503:physiopathology*; D050916:TRPV Cation Channels / Q000235:genetics*; D057170:Translational Research, Biomedical; D015854:Up-Regulation / Q000235:genetics; D054804:Cathelicidins
D023181:Antimicrobial Cationic Peptides; D050916:TRPV Cation Channels; C416986:TRPV4 protein, human; D054804:Cathelicidins