Neuromedin: An insight into its types, receptors and therapeutic opportunities.
Neuropeptides are small protein used by neurons in signal communications. Neuromedin U was the first neuropeptide discovered from the porcine spinal and showed its potent constricting activities on uterus hence was entitled with neuromedin U. Following neuromedin U another of its isoform was discovered neuromedin S which was observed in suprachiasmatic nucleus hence was entitled neuromedin S. Neuromedin K and neuromedin L are of kanassin class which belong to tachykinin family. Bombesin family consists of neuromedin B and neuromedin C. All these different neuromedins have various physiological roles like constrictive effects on the smooth muscles, control of blood pressure, pain sensations, hunger, bone metastasis and release and regulation of hormones. Over the years various newer physiological roles have been observed thus opening ways for various novel therapeutic treatments. This review aims to provide an overview of important different types of neuromedin, their receptors, signal transduction mechanism and implications for various diseases.
Institute of Pharmacy, Nirma University, Ahmedabad, India.
Saumitra
S
Gajjar
Institute of Pharmacy, Nirma University, Ahmedabad, India. Electronic address: drbhoomikampatel@gmail.com.
Bhoomika M
BM
Patel
D000818:Animals; D001839:Bombesin / Q000378:metabolism; D006801:Humans; D009130:Muscle, Smooth / Q000378:metabolism; D015288:Neurokinin A / Q000378:metabolism; D015287:Neurokinin B / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism*; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013552:Swine
D009479:Neuropeptides; D017981:Receptors, Neurotransmitter; C497950:neuromedin S; C082444:neuromedin U receptor; C056900:neuromedin U; D015288:Neurokinin A; D015287:Neurokinin B; D001839:Bombesin
Cancer; Neuromedin; Neuromedin receptors; Pain