Serum high C reactive protein concentrations are related to the intake of dietary macronutrients and fiber: Findings from a large representative Persian population sample.
OBJECTIVE
Serum high-sensitivity CRP is a marker of inflammation and an independent predictor of chronic diseases. However, the effect of diet on serum hs-CRP is unclear. The aim of this study was to investigate the relationship between dietary macronutrient intake and serum hs-CRP.


METHODS
We recruited 9778 adults, aged 35-65years as part of the MASHAD study. Dietary intake was determined using 24-hour dietary recall and several biochemical parameters including serum hs-CRP were measured. Analysis of covariance was used for assessment of crude and energy-adjusted nutrients across quartiles of serum hs-CRP. To find the association of dietary nutrients intake and serum hs-CRP level, we used logistic regression in different model.


RESULTS
Unadjusted and adjusted multivariate analyses indicate that there was a significant positive association between dietary protein and sodium intake and serum hs-CRP concentrations. There was also a positive association with dietary fat and cholesterol and serum hs-CRP in the adjusted models. There was a significant inverse association between dietary carbohydrate and fiber consumption and serum hs-CRP in both crude and adjusted models.


CONCLUSIONS
We have found a significant positive association between the dietary intake of fat, protein, cholesterol and sodium and hs-CRP level, and an inverse correlation between dietary carbohydrate and fiber and serum hs-CRP in a large representative Iranian population.
Student Research Committee, Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Sayyed Saeid
SS
Khayyatzadeh
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Oncology, Division of Palliative Care Medicine, University of Alberta, Edmonton, Alberta, Canada.
Seyyed Mohammad Reza
SMR
Kazemi-Bajestani
Student Research Committee, Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad
M
Bagherniya
Student Research Committee, Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mehraneh
M
Mehramiz
Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Maryam
M
Tayefi
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.. Electronic address: EbrahimiMH@mums.ac.ir.
Mahmoud
M
Ebrahimi
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
Gordon A
GA
Ferns
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad
M
Safarian
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.. Electronic address: ghayourm@mums.ac.ir.
Majid
M
Ghayour-Mobarhan
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology / Q000517:prevention & control*; D000072001:Diet, Healthy / Q000208:ethnology; D059305:Diet, High-Fat / Q000009:adverse effects; D004043:Dietary Fiber / Q000627:therapeutic use*; D004044:Dietary Proteins / Q000009:adverse effects; D002149:Energy Intake / Q000208:ethnology; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010349:Patient Compliance / Q000208:ethnology; D012306:Risk; D057566:Self Report; D012982:Sodium, Dietary / Q000009:adverse effects; D015854:Up-Regulation; D014504:Urban Health / Q000208:ethnology
D015415:Biomarkers; D004043:Dietary Fiber; D004044:Dietary Proteins; D012982:Sodium, Dietary; D002097:C-Reactive Protein
Cardiovascular disease; Dietary intake; Fiber; Inflammation; hs-CRP