Controlled release of antibiotic amoxicillin drug using carboxymethyl cellulose-cl-poly(lactic acid-co-itaconic acid) hydrogel.
In this paper, microwave assisted preparation of carboxymethyl cellulose-cl-poly(lactic acid-co-itaconic acid) (CMC-cl-P(LA-co-IA)) hydrogel was reported via facile graft copolymerization using N,N1-methylene-bis-acrylamide (MBA) and potassium persulphate as cross linker and initiator. Different reaction parameters were optimized to achieve good yield. The formation of hydrogel was confirmed by characterization techniques such as Fourier transform infrared spectroscopy, field emission scanning electron microscopy, X-ray diffraction, thermo gravimetric analysis, transmission electron microscopy etc. The antimicrobial activities of the hydrogel were studied against Staphylococcus aureus and Escherichia coli. About 95% killing of bacteria was recorded after 24h. The controlled release of amoxicillin drug from hydrogel was evaluated as a function of pH and time. Maximum drug release of 98% was recorded at 2.2 pH after 7h. The kinetic studies showed non-Fickian diffusion of the drug.
School of Chemistry, Shoolini University, Solan 173212, Himachal Pradesh, India.
S
S
Sood
Department of Applied Department, University of Johannesburg, Johannesburg, South Africa. Electronic address: vinodg@uj.ac.za.
Vinod Kumar
VK
Gupta
Department of Applied Department, University of Johannesburg, Johannesburg, South Africa.
Shilpi
S
Agarwal
School of Biotechnology, Shoolini University, Solan 173212, Himachal Pradesh, India.
Kamal
K
Dev
School of Chemistry, Shoolini University, Solan 173212, Himachal Pradesh, India. Electronic address: dpathania74@gmail.com.
Deepak
D
Pathania
D000658:Amoxicillin / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013386:Succinates / Q000737:chemistry*; D013696:Temperature
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D013386:Succinates; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D019344:Lactic Acid; D000658:Amoxicillin; D002266:Carboxymethylcellulose Sodium; C005229:itaconic acid
Carboxymethyl cellulose; Itaconic acid; Lactic acid; Targeted drug release