Bacterial lysate for the prevention of chronic rhinosinusitis recurrence in children.
BACKGROUND
Chronic rhinosinusitis is a common nasal disorder in children that is prone to recurrence. This study investigated the prevention of chronic rhinosinusitis recurrence with bacteria lysate in children.


METHODS
Bacteria lysate was administered 10 days per month for 3 months to children with chronic rhinosinusitis, who had just entered a remission phase. Visual analogue score, nasal symptoms scores, rhinitis attack frequency and antibiotic use were assessed at three months and one year.


RESULTS
At one year of follow up, the visual analogue score, nasal discharge and obstruction scores, number of days with rhinitis attacks per month and number of days with antibiotic use per month were significantly decreased in the prevention group versus the control group (p < 0.05).


CONCLUSIONS
Bacterial lysate used in the remission period of rhinosinusitis in children was shown to provide long-term prophylaxis. Bacterial lysate can effectively reduce the frequency of rhinosinusitis attacks and ameliorate attack symptoms.
Department of Otorhinolaryngology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
J
J
Chen
Department of Otorhinolaryngology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
Y
Y
Zhou
Department of Endocrinology,Third Affiliate Hospital of Guangzhou Medical University,Guang Zhou,China.
J
J
Nie
Department of Otorhinolaryngology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
Y
Y
Wang
Department of Otorhinolaryngology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
L
L
Zhang
Department of Otorhinolaryngology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
Q
Q
Shi
Department of Otorhinolaryngology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
H
H
Tan
Department of Otorhinolaryngology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
W
W
Kong
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002457:Cell Extracts / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012008:Recurrence; D012220:Rhinitis / Q000188:drug therapy / Q000517:prevention & control*; D055502:Secondary Prevention / Q000379:methods*; D012852:Sinusitis / Q000188:drug therapy / Q000517:prevention & control*; D016896:Treatment Outcome; D064232:Visual Analog Scale; D000095983:Bacterial Lysates
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D002457:Cell Extracts; C030259:Broncho-Vaxom; D000095983:Bacterial Lysates
Children; Sinusitis; Tertiary Prevention