Hypoxemia after single-shot anesthesia in common marmosets.
It remains unknown how single-shot anesthesia influences physical parameters, especially respiratory function and blood oxygen level of common marmosets (Callithrix jacchus) which came to be used for laboratory research.



We measured blood oxygen levels, both before and after oxygenation, in 13 common marmosets under two single-shot anesthesia conditions: ketamine/xylazine/atropine and alphaxalone.



We found that SpO2values decreased to about 80% in the ketamine/xylazine/atropine protocol and fell just below 90% in the alphaxalone protocol. We observed a clear decrease in PaO2values under the anesthetized condition compared to the awake condition. Our data indicate that single-shot anesthesia may cause hypoxemia in marmosets. Previous studies on other non-human primate have reported no SpO2decrease and hypoxemia; thus, our experiment suggests that marmosets may have a more fragile respiratory system and require intensive veterinary care during anesthesia.
Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan.
Naho
N
Konoike
Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan.
Miki
M
Miwa
Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan.
Akiyo
A
Ishigami
Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan.
Katsuki
0000-0002-2376-8755
K
Nakamura
D000759:Adjuvants, Anesthesia / Q000009:adverse effects*; D000758:Anesthesia / Q000009:adverse effects / Q000662:veterinary*; D000777:Anesthetics / Q000009:adverse effects*; D000818:Animals; D001285:Atropine / Q000009:adverse effects; D002144:Callithrix / Q000502:physiology; D005260:Female; D000860:Hypoxia / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary*; D007649:Ketamine / Q000009:adverse effects; D008297:Male; D008992:Monkey Diseases / Q000139:chemically induced / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D011277:Pregnanediones / Q000009:adverse effects; D012119:Respiration / Q000187:drug effects; D014991:Xylazine / Q000009:adverse effects
D000759:Adjuvants, Anesthesia; D000777:Anesthetics; D011277:Pregnanediones; D014991:Xylazine; D007649:Ketamine; D001285:Atropine; C006477:alphaxalone; D010100:Oxygen
alphaxalone; arterial blood gas; ketamine; non-human primates