Side effects of pain and analgesia in animal experimentation.
This review highlights selected effects of untreated pain and of widely used analgesics such as opioids, non-steroid anti-inflammatory drugs and antipyretics, to illustrate the relevance of carefully planned, appropriate and controlled analgesia for greater reproducibility in animal experiments involving laboratory rodents.
Division of Surgical Research, University Hospital Zürich, University of Zürich, Zürich, Switzerland.
Paulin
P
Jirkof
D000698:Analgesia / Q000009:adverse effects / Q000662:veterinary*; D000700:Analgesics / Q000009:adverse effects*; D000701:Analgesics, Opioid / Q000009:adverse effects; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D058633:Antipyretics / Q000009:adverse effects; D010146:Pain / Q000517:prevention & control / Q000662:veterinary*; D012377:Rodentia
D000700:Analgesics; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D058633:Antipyretics