Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report.
Acrodermatitis enteropathica syndrome (AE) is a clinical entity that results in severe zinc deficiency. It can be genetic or acquired. Acquired AE has been reported in patients with chronic liver disease, malabsorption syndrome, sickle cell anemia, and chronic renal failure. We present a kidney transplant recipient with skin rash and watery diarrhea. The patient had low serum zinc levels, which quickly resolved after zinc supplementation. Skin biopsy showed cytoplasmic pallor and vacuolization and ballooning degeneration of keratinocytes within the superficial epidermis, which may have led to confluent necrosis of keratinocytes. Large amounts of keratinosome-derived lamellae were found in the intercellular spaces in the keratinized area, probably related to disturbance of keratinosome metabolism due to zinc deficiency.
Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
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Bayraktar
Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
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Bakkaloglu
Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: eroldemir83@yahoo.com.
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Demir
Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
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Turkmen
Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
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Azamat
Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
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Caliskan
Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
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Sari
Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
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Buyukbabani
Department of Dermatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
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Baykal
Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
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Aydin
D000169:Acrodermatitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D003879:Dermatologic Agents / Q000627:therapeutic use; D003967:Diarrhea / Q000209:etiology; D004817:Epidermis / Q000473:pathology; D005533:Foot Dermatoses / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006229:Hand Dermatoses / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D055815:Young Adult; D015032:Zinc / Q000172:deficiency* / Q000627:therapeutic use
D003879:Dermatologic Agents; D015032:Zinc