Clinical application prospect of umbilical cord-derived mesenchymal stem cells on clearance of advanced glycation end products through autophagy on diabetic wound.
Nowadays, wound healing delay due to diabetes is considered to be closely related to the accumulation of advanced glycation end products (AGEs). Although mesenchymal stem cells (MSCs) exhibit positive effects on diabetic wound healing, related mechanisms are still not fully elucidated. It has been reported that MSCs can improve the activity of autophagy in injured tissues, thereby playing an important role in wound healing. The autophagy induced by MSCs may be beneficial to diabetic wound healing via removing AGEs, which provide new ideas for clinical treatment of diabetic wounds with the potential of broad application prospects. In this study, the current research situation and application prospect of umbilical cord-derived MSCs on the clearance of AGEs in diabetic wound were reviewed.
Department of Plastic Surgery, Beijing Shijitan Hospital, Capital Medical University, 10 Tieyilu, Yangfangdian, Haidian District, Beijing, 100038, People's Republic of China. dochyf@163.com.
Yanfu
http://orcid.org/0000-0003-3966-8684
Y
Han
Department of Burn and Plastic Surgery, Hainan Branch of People's Liberation Army General Hospital, Haitangwan, Sanya, People's Republic of China.
Tianjun
T
Sun
Department of Plastic Surgery, PLA General Hospital, 28 Fuxing Road, Beijing, People's Republic of China.
Ran
R
Tao
School of Electrical and Information Engineering, Wuhan Institute of Technology, 366 Huquan, Wuhan, People's Republic of China.
Yanqing
Y
Han
Department of Plastic Surgery, Beijing Shijitan Hospital, Capital Medical University, 10 Tieyilu, Yangfangdian, Haidian District, Beijing, 100038, People's Republic of China.
Jing
J
Liu
D000818:Animals; D001343:Autophagy / Q000235:genetics; D048909:Diabetes Complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D017127:Glycation End Products, Advanced / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells; D012867:Skin / Q000378:metabolism / Q000473:pathology; D014470:Umbilical Cord / Q000166:cytology / Q000378:metabolism*; D014945:Wound Healing / Q000235:genetics* / Q000502:physiology
D017127:Glycation End Products, Advanced
Advanced glycosylation end products; Application; Diabetic wound; Mesenchymal stem cells; Wound healing