The use of enrichment to reduce statistically indeterminate or negative trials in critical care.
Department of Intensive Care Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.|Division of Asthma, Allergy and Lung Biology, Kings College, London, UK.
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M
Shankar-Hari
Interdepartmental Division of Critical Care Medicine, University of Toronto, Chief, Program in Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Center, Toronto, Canada.
G D
GD
Rubenfeld
D003422:Critical Care; D004198:Disease Susceptibility; D006801:Humans; D000076723:Negative Results; D011897:Random Allocation; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D012128:Respiratory Distress Syndrome / Q000628:therapy
ARDS; critical care; enrichment; heterogeneity; sepsis