Aligning a Synapse.
Synaptic communication requires alignment of transmitter release sites with transmitter receptors. In this issue of Neuron, Wang et al. (2017) show that α2δ4 subunits link calcium channels to a trans-synaptic complex with glutamate receptors at the visual system's first synapse.
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University School of Medicine, Saint Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: kerschensteinerd@wustl.edu.
Daniel
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Kerschensteiner
D015220:Calcium Channels; D006801:Humans; D009474:Neurons; D013569:Synapses; D009435:Synaptic Transmission
D015220:Calcium Channels