The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction.
Purpose.This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in a model of renal mass reduction.Methods. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment (n= 14); RMR + CAA: RMR rats treated with CAA (n= 13); SO: SO rats without treatment (n= 13); and SO + CAA: SO rats treated with CAA (n= 13). CAA was intraperitoneally administered in a dose of 0.23µg/Kg three times a week for six months.Results.RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity (p< 0.05) and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAA administration significantly increased catalase and GR activity (p< 0.05) and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio. No significant differences were found between the RMR groups in any of the parameters of renal function. However, CAA administration slightly improves some parameters of renal function.Conclusions.These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress.
Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal; Department of Therapeutic and Diagnostic Technologies, Polytechnic Institute of Bragança (IPB), Bragança, Portugal.
António
A
Nogueira
Department of Biology and Environment, School of Life Science and Environment, UTAD, Vila Real, Portugal; Center for the Research and Technology of Agro-Environmental and Biological Science (CITAB), UTAD, Vila Real, Portugal.
Francisco
0000-0001-9729-7477
F
Peixoto
Department of Chemistry, School of Life Science and Environment, UTAD, Vila Real, Portugal; Chemistry Center of Vila Real (CQVR), UTAD, Vila Real, Portugal.
Maria Manuel
MM
Oliveira
Department of Mathematics, School of Science and Technology, UTAD, Vila Real, Portugal.
Carlos André
CA
Pires
Center for the Research and Technology of Agro-Environmental and Biological Science (CITAB), UTAD, Vila Real, Portugal; Department of Zootechnic, School of Agrarian and Veterinary Sciences, UTAD, Vila Real, Portugal.
Bruno
B
Colaço
Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal; Center for the Research and Technology of Agro-Environmental and Biological Science (CITAB), UTAD, Vila Real, Portugal.
Paula Alexandra
0000-0001-9519-4044
PA
Oliveira
Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal; Center for the Research and Technology of Agro-Environmental and Biological Science (CITAB), UTAD, Vila Real, Portugal.
Maria João
0000-0003-1036-3326
MJ
Pires
D000818:Animals; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology / Q000601:surgery; D007674:Kidney Diseases / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008297:Male; D008298:Maleates / Q000008:administration & dosage*; D009392:Nephrectomy / Q000009:adverse effects; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
D008298:Maleates; C080569:chaetomellic acid A; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione