Effect of remote ischemic postconditioning during thrombolysis in STEMI.
BACKGROUND
Remote ischemic postconditioning (RIPC) is suggested to protect the myocardium against ischemia in various settings. However, the effect of RIPC in patients with acute ST-elevation myocardial infarction (STEMI) who undergo thrombolysis has yet to be examined.


METHODS
In this single-center, randomized controlled trial, we examined the effect of RIPC on the resolution of ST-segment elevation (STR) in response to thrombolysis. Patients in the RIPC group had three cycles of 5‑min cuff inflation followed by 5‑min deflation to the upper arm.


RESULTS
The study comprised 78 patients (15 women), of whom 41 were randomized to the RIPC group and 37 to the control group. STR occurred in 61% of the patients in the RIPC group, while it was detected only in 35% of controls (p = 0.026). Although STR was more common in the RIPC group, there was no difference in the extent of ΣCK-48 h between the two groups. Furthermore, the length of hospital stay and the frequency of adverse events were similar between the RIPC and control groups.


CONCLUSIONS
RIPC during thrombolytic therapy in STEMI was associated with a higher frequency of STR. However, it did not affect enzymatic infarct size or the frequency of adverse events. (Clinical trial registration number: IRCT2014011916229N2.).
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
S
S
Ghaffari
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.|Department of Anesthesiology, University at Buffalo, 77 Goodell Street, Suite #510, 14203, Buffalo, NY, USA.
L
L
Pourafkari
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
S
S
Manzouri
Department of Anesthesiology, University at Buffalo, 77 Goodell Street, Suite #510, 14203, Buffalo, NY, USA. nnader@buffalo.edu.
N D
ND
Nader
D000368:Aged; D004562:Electrocardiography; D005260:Female; D006801:Humans; D057775:Ischemic Postconditioning / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D000072657:ST Elevation Myocardial Infarction / Q000628:therapy*; D015912:Thrombolytic Therapy
Ischemia; Myocardium; Reperfusion; ST-segment elevated myocardial infarction (STEMI); Thrombolytic therapy