The role of miRNA-223 in cancer: Function, diagnosis and therapy.
MicroRNAs (miRNAs) constitute a large family of small, non-coding RNAs with the capacity to regulate gene expression post-transcriptionally. miRNAs appear to hold promise of mechanistic explanations for various physiological and pathological processes. miRNA-223 is highly conserved and preferentially expressed in the hematopoietic system in regulation of myeloid differentiation. Recently, increasing evidence suggests that miRNA-223 may also play an essential part in both hematological malignancies and solid tumors. miRNA-223 can function as either an oncogene or a tumor suppressor gene, which is achieved by targeting a wide range of genes and regulating downstream signal transduction. As yet, the function of miR-223 in cancer has not been fully characterized and understood. To make it more clear, this review firstly summarizes the present understanding of the regulation of miR-223 at the molecular level, its crucial role in oncogenesis, development, and metastasis, its function as a diagnostic and prognostic biomarker and finally, its potential applications in monitoring and therapy of diverse types of malignancies.
Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China; Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, United States.
Yunliang
Y
Gao
Department of Urology, Fujian Medical University Teaching Hospital, Fujian Provincial Hospital, Fuzhou 350001, PR China.
Le
L
Lin
Department of Urology, Fujian Medical University Teaching Hospital, Fujian Provincial Hospital, Fuzhou 350001, PR China.
Tao
T
Li
Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China. Electronic address: yjinrui2012@163.com.
Jinrui
J
Yang
Department of Urology, Fujian Medical University Teaching Hospital, Fujian Provincial Hospital, Fuzhou 350001, PR China. Electronic address: weiyb2008@163.com.
Yongbao
Y
Wei
D014408:Biomarkers, Tumor / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D011379:Prognosis; D015398:Signal Transduction
D014408:Biomarkers, Tumor; D035683:MicroRNAs; C525067:MIR223, human
Biological function; Biomarker; Cancer; Oncogene; Oncotherapy; Tumor promoter; miR-223