Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients.
Diabetic nephropathy (DN) is one of the major chronic complications of diabetes. Genetic polymorphism of Apolipoprotein E (ApoE) has been proposed to participating in DN. The purpose of the study was to evaluate the relationship between ApoE genetic polymorphism and the presence of DN in Chinese type 2 diabetic patients. We studied 845 diabetic patients who were divided into DN group (n= 429) and control group (n= 416). ApoE genotype was determined by ApoE genotyping chip and the plasmatic biochemical characterization was performed on all subjects. There were differences (P< 0.001) in HbA1c, creatinine, and urinary albumin between the two groups. The ApoEε2 allelic frequency was 7.69% in DN group versus 3.49% in control group (OR = 2.22, 95% CI = 1.41-3.47, andP< 0.05), as expected, ApoE E2/E2 and E2/E3 genotype frequency were higher in DN group (13.75% versus 6.49%,P< 0.05). The ApoEε4 allelic frequency was 7.93% in DN group versus 11.54% in control group (OR = 0.70, 95% CI = 0.50-0.97, andP< 0.05), and DN group presented a lower frequency of ApoE E3/E4 and E4/E4 genotype frequency (14.91% versus 19.96%,P< 0.05). These results suggest ApoEε2 allele may be a risk factor; however ApoEε4 allele may play a protective role of DN in Chinese type 2 diabetic patients.
Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
YongWei
0000-0002-4974-0283
Y
Jiang
Graduate School of Peking Union Medical College, Beijing, China; Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China.
Liang
L
Ma
Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
ChengWu
C
Han
Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
Qian
Q
Liu
Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
Xiao
X
Cong
Department of Pathophysiology, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China.
YaPing
Y
Xu
Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China.
TingTing
T
Zhao
Graduate School of Peking Union Medical College, Beijing, China; Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China.
Ping
0000-0002-3315-2276
P
Li
Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
YongTong
0000-0003-1881-2069
Y
Cao
D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People; D002681:China; D003928:Diabetic Nephropathies / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D065840:Protective Factors; D020033:Protein Isoforms / Q000235:genetics*
D001057:Apolipoproteins E; D020033:Protein Isoforms