[The functions of calcium-sensing receptor in regulating mineral metabolism.]
Calcium-sensing receptor(CaSR)which belongs to a G protein-coupled receptor family is one of the key elements in regulating calcium homeostasis. CaSR has been identified as a receptor to control parathyroid hormone(PTH)secretion in parathyroid glands according to serum calcium ion(Ca2+)levels. It has also been shown that CaSR controls reabsorption of water and several cations including Ca2+and magnesium ion(Mg2+)in renal tubular cells. This review summarizes the functions and roles of CaSR in mineral metabolism that are exerted in parathyroid glands, kidney, and intestine.
The functions of calcium-sensing receptor in regulating mineral metabolism.
Yuka
Y
Kinoshita
D000818:Animals; D015519:Bone Density; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D044169:Receptors, Calcium-Sensing / Q000235:genetics / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism
D044169:Receptors, Calcium-Sensing; D002118:Calcium