Prognostic Significance of Neutrophil to Lymphocyte Ratio, Lymphocyte to Monocyte Ratio, and Platelet to Lymphocyte Ratio in Patients with Nasopharyngeal Carcinoma.
The peripheral blood neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) have been reported to correlate with the prognosis of many malignancies. This study evaluated the prognostic value of pretreatment NLR, LMR, and PLR in nasopharyngeal carcinoma (NPC). A retrospective analysis of clinical and pathological data of 140 NPC patients without distant metastasis during initial treatment was conducted to identify correlations between NLR, LMR, and PLR and clinicopathological features, overall survival, and progression-free survival. Cox proportional hazard regression analysis was used to reveal the independent factors affecting the prognosis of NPC patients. NLR was associated with T staging, N staging, and overall clinical stage grouping of the NPC patients (P< 0.05). NLR ≥ 2.28, LMR < 2.26, and PLR ≥ 174 were significantly associated with a relatively short overall survival (P< 0.05). In addition, NLR ≥ 2.28 was significantly associated with a relatively short progression-free survival (P< 0.05). Cox proportional hazard regression analysis showed that NLR was an independent prognostic factor in NPC. Pretreatment NLR, LMR, and PLR might be a useful complement to TNM staging in the prognostic assessment of NPC patients.
Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, Guangxi 543002, China; Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
Aiying
A
Lu
Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
Haifeng
H
Li
Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, Guangxi 543002, China.
Yuming
Y
Zheng
Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, Guangxi 543002, China; Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
Minzhong
M
Tang
Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, Guangxi 543002, China; Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
Jun
J
Li
Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
Huihui
H
Wu
Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
Weiming
W
Zhong
Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
Jianquan
J
Gao
Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
Ningjiang
N
Ou
Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, Guangxi 543002, China; Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
Yonglin
0000-0002-2001-1351
Y
Cai
D000293:Adolescent; D000328:Adult; D000368:Aged; D001792:Blood Platelets; D002277:Carcinoma; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009000:Monocytes; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000097:blood / Q000401:mortality; D009504:Neutrophils; D010976:Platelet Count; D015996:Survival Rate