Further investigation of a quantitative trait locus for ascites on chromosome 9 in broiler chicken lines.
Previously, we reported a genome wide association study (GWAS) that had shown association of a region between 11.8 and 13.6 Mbp on chromosome 9 with ascites phenotype in broilers. We had used microsatellite loci to demonstrate an association of particular genotypes for this region with ascites in experimental ascites lines and commercial broiler breeder lines. We identified two potential candidate genes, AGTR1 and UTS2D, within that chromosomal region for mediating the quantitative effect. We have now extended our analysis using SNPs for these genes to assess association with resistance or susceptibility to ascites in these same broiler lines. Surprisingly, in contrast to our previous GWAS and microsatellite data for this region, we find no association of the SNP genotypes or haplotypes in the region suggesting that the two genes might have limited association with the disease phenotype.
Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, AR 72701.|Department of Biological Sciences, University of Arkansas, Fayetteville, AR 72701.
Shatovisha
S
Dey
Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, AR 72701.
Sriram
S
Krishna
Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, AR 72701.|Department of Poultry Sciences, University of Arkansas, Fayetteville, AR 72701.
Nicholas B
NB
Anthony
Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, AR 72701.|Department of Biological Sciences, University of Arkansas, Fayetteville, AR 72701.
Douglas D
DD
Rhoads
D000818:Animals; D001201:Ascites / Q000235:genetics / Q000662:veterinary*; D030161:Avian Proteins / Q000235:genetics / Q000378:metabolism; D002645:Chickens; D002874:Chromosome Mapping / Q000662:veterinary; D005260:Female; D008297:Male; D036361:Peptide Hormones / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011201:Poultry Diseases / Q000235:genetics*; D040641:Quantitative Trait Loci; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics* / Q000378:metabolism
D030161:Avian Proteins; D036361:Peptide Hormones; D044140:Receptor, Angiotensin, Type 1
AGTR1; UTS2D; ascites; pulmonary hypertension; quantitative trait loci