Visual Morbidity and Ocular Complications in Presumed Intraocular Tuberculosis: An Analysis of 354 Cases from a Non-Endemic Population.
OBJECTIVE
To describe the visual morbidity associated with intraocular tuberculosis (TB) and to report ocular complications of intraocular TB.


METHODS
Retrospective cohort study of patients diagnosed with intraocular TB at a tertiary referral eye care hospital in central London. Data on baseline and final best-corrected visual acuity (BCVA) along with ocular complications were collected and analyzed.


RESULTS
In total, 354 patients with intraocular TB were included in this study. Mean age was 48.45 years (range 19-94) and follow-up was 22.56 ± 7.44 (range 6-30) months post cessation of therapy. Blindness as defined by the World Health Organization was reported in 11 (3.11%) patients at baseline and 13 (3.67%) patients at follow-up. The most common ocular complications were cystoid macular edema (n = 107, 30.5%) and glaucoma (n = 99, 28.12%).


CONCLUSIONS
Intraocular TB can be associated with significant ocular morbidity. Early recognition, treatment, and regular follow-up of this complex disease may help to reduce visual morbidity and ocular complications.
a National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore , Singapore.|b Moorfields Eye Hospital, NHS Foundation Trust , London , UK.
Dinesh Visva
DV
Gunasekeran
b Moorfields Eye Hospital, NHS Foundation Trust , London , UK.|c Royal Berkshire Hospital, NHS Foundation Trust , Reading , UK.
Bhaskar
B
Gupta
b Moorfields Eye Hospital, NHS Foundation Trust , London , UK.
Joao
J
Cardoso
b Moorfields Eye Hospital, NHS Foundation Trust , London , UK.|d Biomedical Research Centre, UCL Institute of Ophthalmology , London , UK.
Carlos E
CE
Pavesio
a National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore , Singapore.|b Moorfields Eye Hospital, NHS Foundation Trust , London , UK.|d Biomedical Research Centre, UCL Institute of Ophthalmology , London , UK.
Rupesh
R
Agrawal
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008131:London / Q000453:epidemiology; D008269:Macular Edema / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014392:Tuberculosis, Ocular / Q000150:complications* / Q000453:epidemiology; D015354:Vision, Low / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D014792:Visual Acuity; D055815:Young Adult
Clinical features; intraocular tuberculosis; posterior uveitis; tuberculosis; visual morbidity