Yttrium-90 microsphere radioembolization in unresectable intrahepatic cholangiocarcinoma.
Intrahepatic cholangiocarcinoma is increasing in frequency worldwide, but radical surgical treatment is practicable in 30-40% of cases. The median survival without therapy is about 8 months, increased to 12 months in combination with systemic chemotherapy. Therefore, locoregional therapies, such as, radiofrequency ablation or transarterial chemoembolization have been employed. Radioembolization with yttrium-90 microspheres (90Y-TARE) is a novel intrarterial treatment which could be included in the armamentarium of treatment options, having shown higher median survival (up to 22 months) and low complication rates. Evidence-based algorithms for staging and allocation to treatment should be defined in the future, after robust results obtained through randomized controlled trials, thus establishing the exact role and timing of90Y-TARE in the treatment protocol of unresectable intrahepatic cholangiocarcinoma.
Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi University Hospital, Bologna, Italy.
Cristina
C
Mosconi
Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi University Hospital, Bologna, Italy.
Alberta
A
Cappelli
Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi University Hospital, Bologna, Italy.
Salvatore
S
Ascanio
Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi University Hospital, Bologna, Italy.
Irene
I
Pettinari
Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi University Hospital, Bologna, Italy.
Francesco
F
Modestino
Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi University Hospital, Bologna, Italy.
Matteo
M
Renzulli
Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi University Hospital, Bologna, Italy.
Maria Cristina
MC
Galaverni
Department of Medical & Surgical Sciences, S.Orsola - Malpighi Hospital, Alma Mater Studiorum, University of Bologna, Italy.
Alessandro
A
Cucchetti
Department of Medical & Surgical Sciences, Alma Mater Studiorum, University of Bologna, Italy.
Annagiulia
A
Gramenzi
Medical Physics Unit, Radiology Unit, S Orsola-Malpighi Hospital, Bologna, Italy.
Cinzia
C
Pettinato
Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi University Hospital, Bologna, Italy.
Rita
R
Golfieri
D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000532:radiotherapy*; D001653:Bile Ducts, Intrahepatic / Q000000981:diagnostic imaging / Q000528:radiation effects; D001918:Brachytherapy / Q000379:methods*; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000401:mortality / Q000532:radiotherapy*; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D008863:Microspheres; D018579:Patient Selection; D011300:Preoperative Care / Q000379:methods; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D066066:Response Evaluation Criteria in Solid Tumors; D015021:Yttrium Radioisotopes / Q000008:administration & dosage*
D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes; C000615496:Yttrium-90
ICC; intrahepatic cholangiocarcinoma; radioembolization; yttrium-90