Design of a dual slot antenna for small animal microwave ablation studies.
This study presents the development of a dual-slot antenna for small animal tumor ablation. By using a dual-slot design at 8 GHz, it was hypothesized that smaller and more spherical ablations can be produced. After computer-aided design optimization, antennas were fabricated and ablations performed at 5-20 W for 15-120 s with the objective of creating ablations with a diameter/length aspect ratio of at least 0.9. The new dual-slot design at 8 GHz created significantly more spherical ablations than a commercial antenna at 2.45 GHz in ex vivo liver tissue (Average Aspect Ratio 0.8081 vs. 0.4532, p <;<; 0.05). In vivo studies confirmed the highly spherical results ex vivo. Initial testing shows that the dual-slot antenna and 8 GHz generator can be used to ablate tumors in mice.
Tyler J
TJ
Moon
Christopher L
CL
Brace
D000818:Animals; D017115:Catheter Ablation / Q000295:instrumentation* / Q000379:methods*; D002417:Cattle; D003198:Computer Simulation; D004867:Equipment Design; D008099:Liver / Q000473:pathology; D008872:Microwaves; D013997:Time Factors