Cognitive Control Processes and Functional Cerebral Asymmetries: Association with Variation in the Handedness-Associated Gene LRRTM1.
Cognitive control processes play an essential role not only in controlling actions but also in guiding attentional selection processes. Interestingly, these processes are strongly affected by organizational principles of the cerebral cortex and related functional asymmetries, but the neurobiological foundations are elusive. We ask whether neurobiological mechanisms that affect functional cerebral asymmetries will also modulate effects of top-down control processes on functional cerebral asymmetries. To this end, we examined potential effects of the imprinted gene leucine-rich repeat transmembrane neuronal 1 (LRRTM1) on attentional biasing processes in a forced attention dichotic listening task in 983 healthy adult participants of Caucasian descent using the "iDichotic smartphone app." The results show that functional cerebral asymmetries in the language domain are associated with the rs6733871 LRRTM1 polymorphism when cognitive control and top-down attentional mechanisms modulate processes in bottom-up attentional selection processes that are dependent on functional cerebral asymmetries. There is no evidence for an effect of LRRTM1 on functional cerebral asymmetries in the language domain unrelated to cognitive control processes. The results suggest that cognitive control processes are an important factor to consider when being interested in the molecular genetic basis of functional cerebral architecture.
Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany. christian.beste@uniklinikum-dresden.de.|Experimental Neurobiology, National Institute of Mental Health, Klecany, Czech Republic. christian.beste@uniklinikum-dresden.de.
Christian
C
Beste
Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany.
Larissa
L
Arning
Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany.
Wanda M
WM
Gerding
Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany.
Jörg T
JT
Epplen
Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Bochum, Germany.
Alexandra
A
Mertins
Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Bochum, Germany.
Melanie C
MC
Röder
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
Josef J
JJ
Bless
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.|NORMENT Center of Excellence, University of Oslo, Oslo, Norway.|Department of Psychiatry, Haukekland University Hospital, Bergen, Norway.
Kenneth
K
Hugdahl
Department of Psychology, University of Oslo, Oslo, Norway.
René
R
Westerhausen
Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Bochum, Germany.
Onur
O
Güntürkün
Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Bochum, Germany.
Sebastian
S
Ocklenburg
D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007802:Language; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011795:Surveys and Questionnaires; D055815:Young Adult
C526971:LRRTM1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins
Cerebral asymmetries; Cognitive control; Dichotic listening; Genetics; LRRTM1; Smartphone