Autologous and Allogeneic Hematopoietic Cell Transplantation in Peripheral T/NK-cell Lymphomas: A Histology-Specific Review.
Peripheral T-cell lymphoma and natural killer/T-cell lymphomas (PT/NKCL) make up a diverse subgroup of non-Hodgkin's lymphomas characterized by an aggressive clinical course. The use of hematopoietic stem cell transplantation (HSCT) in the treatment of PT/NKCL remains controversial because of the absence of randomized controlled trials. The best available data suggest that certain subtypes of PT/NKCL may benefit more from the application of HSCT than other subtypes and that this benefit results from their unique clinical characteristics and underlying biology. Ultimately, however, prospective randomized controlled trials are needed to clarify the optimal type and timing of HSCT in patients with PT/NKCL.
Department of Medicine, University of Washington School of Medicine, SCCA, 825 Eastlake Avenue East, M-Box G3-200, Seattle, WA 98109, USA.
Tejaswini M
TM
Dhawale
Department of Medicine, University of Washington School of Medicine, SCCA, 825 Eastlake Avenue East, M-Box G3-200, Seattle, WA 98109, USA. Electronic address: ashustov@seattlecca.org.
Andrei R
AR
Shustov
D064591:Allografts; D064592:Autografts; D018380:Hematopoietic Stem Cell Transplantation; D054391:Lymphoma, Extranodal NK-T-Cell / Q000145:classification / Q000473:pathology / Q000628:therapy
Hematopoietic stem cell transplantation; Histology; Molecular biology; Natural killer/T-cell lymphoma; Pathophysiology; Peripheral T-cell lymphoma; Treatment