Comparison of Two Different Inhalation Anesthetics on Grafted Kidney Function in Patients Undergoing Renal Transplantation Surgery: Desflurane or Sevoflurane?
BACKGROUND
Anesthetic management of patients during renal transplantation is vitally important for ensuring proper functioning of kidneys that have undergone ischemia-reperfusion damage. The goal of this prospective study was to compare the effects of 2 different inhalation agents (sevoflurane and desflurane) on grafted kidney function in renal transplantation surgery.


METHODS
Sixty-five patients who were scheduled for living donor renal transplantation were enrolled in the study. General anesthesia was performed on all patients. Thirty-five pairs of recipients and donors were anesthetized with sevoflurane (group S) and 30 pairs of recipients and donors were anesthetized with desflurane (group D). Each patient's demographic characteristics, immunologic and clinical data, and hemodynamic parameters were recorded. The estimated glomerular filtration rate was calculated in the preoperative period and on postoperative days 1 and 7. The blood samples were collected before the operation and on postoperative days 1 and 7 for measurement of serum creatinine, neutrophil gelatinase-associated lipocalin, and interleukin 18.


RESULTS
There were no significant differences in demographic characteristics or immunologic data between group D and group S. Intraoperative heart rate and mean arterial blood pressure were the same between groups. Creatinine, estimated glomerular filtration rate, neutrophil gelatinase-associated lipocalin, and interleukin 18 values did not differ between groups (P > .05) in the preoperative period and postoperative days 1 and 7.


CONCLUSIONS
Sevoflurane and desflurane had no adverse effects on grafted kidney functions according to short-term graft outcomes in patients undergoing living donor renal transplantation.
Department of Anesthesiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey. Electronic address: mskaradeniz@gmail.com.
M S
MS
Karadeniz
Department of Medical Biology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
H S
HS
Ciftci
Department of Urology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
T
T
Tefik
Department of Anesthesiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
O
O
Mammadov
Department of Nephrology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
H
H
Yazıcı
Department of Urology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
I
I
Nane
Department of Nephrology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
A
A
Turkmen
Department of Medical Biology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
F
F
Oguz
Department of Anesthesiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
K M
KM
Tugrul
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D018685:Anesthetics, Inhalation / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D000077335:Desflurane; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008738:Methyl Ethers / Q000627:therapeutic use*; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D003404:Creatinine; D000077335:Desflurane; D007530:Isoflurane