Consecutive One-Pot versus Domino Multicomponent Approaches to 3-(Diarylmethylene)oxindoles.
Based on consecutive one-pot conditions combining three palladium-catalyzed reactions (Sonogashira, Heck and Suzuki-Miyaura reactions), a more efficient domino multicomponent method has been successfully developed to access a wide variety of 3-(diarylmethylene)oxindoles. Microwave irradiation and use of a silver salt were the most important factors to achieve high yields and stereoselectivity.
Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea. sunalovegs@catholic.ac.kr.
Sunhwa
S
Park
Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea. ljiy727@catholic.ac.kr.
Jiyun
J
Lee
Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea. kyejung@catholic.ac.kr.
Kye Jung
KJ
Shin
Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea. eoh@catholic.ac.kr.
Euichaul
E
Oh
Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea. jaehongseo@catholic.ac.kr.
Jae Hong
JH
Seo
D060326:Chemistry Techniques, Synthetic; D007211:Indoles / Q000138:chemical synthesis*; D008024:Ligands; D008872:Microwaves; D000078183:Oxindoles; D013237:Stereoisomerism; D013696:Temperature
D007211:Indoles; D008024:Ligands; D000078183:Oxindoles; C022960:2-oxindole
3-(diarylmethylene)oxindole; consecutive one-pot reaction; domino reaction; microwave irradiation; palladium-catalyzed reaction