The role of IL-7 in Immunity and Cancer.
Interleukin-7 (IL-7) is a cytokine that has been known since long in immunology, mainly regarding its effects on T-cells and B-cells. IL-7 has been demonstrated to be necessary for both B-cell and T-cell proliferation and lack of IL-7 causes immature immune cell arrest. Interestingly, in recent years, certain studies have strongly suggested that the role of IL-7 is far beyond the field of immunology, it might have direct or indirect effect on cancer. This review aims to summarize the role of IL-7 in immunity and its role in the pathogenesis of neoplasia.
Department of Microbiology, Immunology and Pathology, Des Moines University, Des Moines, IA, U.S.A.
Jack
J
Lin
Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A.
Ziwen
Z
Zhu
Department of Microbiology, Immunology and Pathology, Des Moines University, Des Moines, IA, U.S.A.|The Affiliated Hospital of Xiangnan University, Chenzhou, P.R. China.
Huaping
H
Xiao
Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A.
Mark R
MR
Wakefield
Department of Microbiology, Immunology and Pathology, Des Moines University, Des Moines, IA, U.S.A.
Vivi A
VA
Ding
Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A.
Qian
Q
Bai
Department of Microbiology, Immunology and Pathology, Des Moines University, Des Moines, IA, U.S.A. yujiang.fang@dmu.edu.|Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A.
Yujiang
Y
Fang
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000166:cytology; D002454:Cell Differentiation; D049109:Cell Proliferation; D015321:Gene Rearrangement; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D015851:Interleukin-7 / Q000502:physiology*; D008213:Lymphocyte Activation; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D013601:T-Lymphocytes / Q000166:cytology
D000970:Antineoplastic Agents; C508605:IL7 protein, human; D015851:Interleukin-7; D000135:Acid Phosphatase; C428439:prostatic acid phosphatase
IL-7; immunity cancer; review