Unprecedented highly efficient capture of glycopeptides by Fe3O4@Mg-MOF-74 core-shell nanoparticles.
Magnetic Fe3O4nanospheres coated with Mg-MOF-74 have been facilely prepared via epitaxial growth. Owing to the intrinsic hydrophilic pore surface and size-exclusive properties of Mg-MOF-74, the Fe3O4@Mg-MOF-74 core-shell nanoparticles show effective and selective enrichment of 441 N-glycosylation sites of 418 glycopeptides from 125 glycoproteins in 1 μL of human serum.
Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China. yunling@fudan.edu.cn ymzhou@fudan.edu.cn.
Jie
J
Li
Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
Jiaxi
J
Wang
Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China. yunling@fudan.edu.cn ymzhou@fudan.edu.cn.
Yun
http://orcid.org/0000-0002-6956-4504
Y
Ling
Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China. yunling@fudan.edu.cn ymzhou@fudan.edu.cn.
Zhenxia
Z
Chen
Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
Mingxia
M
Gao
Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
Xiangmin
http://orcid.org/0000-0002-4282-7992
X
Zhang
Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China. yunling@fudan.edu.cn ymzhou@fudan.edu.cn.
Yaming
Y
Zhou