When TLRs fail, IgG has your back.
Inherited TIRAP deficiency confers susceptibility to staphylococcal disease via impaired TLR2 and TLR4 responses, which can be rescued by bacteria-specific antibodies.
Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA. Email: tiffany.scharschmidt@ucsf.edu.
Tiffany C
TC
Scharschmidt
D056704:Adaptive Immunity; D006801:Humans; D007113:Immunity, Innate; D007074:Immunoglobulin G; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4
D007074:Immunoglobulin G; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4