A Replicated, Genome-Wide Significant Association of Aortic Stenosis With a Genetic Variant for Lipoprotein(a): Meta-Analysis of Published and Novel Data.
From Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (B.J.C., R.C.T., J.G.); British Heart Foundation Centre of Research Excellence, University of Oxford, United Kingdom (B.J.C.); Kolling Institute, University of Sydney, Australia (S.C.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (S.C.); Guy's and St Thomas' Hospitals, London, United Kingdom (B.P.); Department of Medicine, McGill University, Montreal, QC, Canada (J.C.E., G.T.); McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada (M.L.); Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute, Montreal, QC, Canada (G.T.); and Clinical Trial Service Unit and Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (R.C.). ben.cairns@ceu.ox.ac.uk.
Benjamin J
BJ
Cairns
From Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (B.J.C., R.C.T., J.G.); British Heart Foundation Centre of Research Excellence, University of Oxford, United Kingdom (B.J.C.); Kolling Institute, University of Sydney, Australia (S.C.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (S.C.); Guy's and St Thomas' Hospitals, London, United Kingdom (B.P.); Department of Medicine, McGill University, Montreal, QC, Canada (J.C.E., G.T.); McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada (M.L.); Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute, Montreal, QC, Canada (G.T.); and Clinical Trial Service Unit and Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (R.C.).
Sean
S
Coffey
From Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (B.J.C., R.C.T., J.G.); British Heart Foundation Centre of Research Excellence, University of Oxford, United Kingdom (B.J.C.); Kolling Institute, University of Sydney, Australia (S.C.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (S.C.); Guy's and St Thomas' Hospitals, London, United Kingdom (B.P.); Department of Medicine, McGill University, Montreal, QC, Canada (J.C.E., G.T.); McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada (M.L.); Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute, Montreal, QC, Canada (G.T.); and Clinical Trial Service Unit and Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (R.C.).
Ruth C
RC
Travis
From Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (B.J.C., R.C.T., J.G.); British Heart Foundation Centre of Research Excellence, University of Oxford, United Kingdom (B.J.C.); Kolling Institute, University of Sydney, Australia (S.C.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (S.C.); Guy's and St Thomas' Hospitals, London, United Kingdom (B.P.); Department of Medicine, McGill University, Montreal, QC, Canada (J.C.E., G.T.); McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada (M.L.); Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute, Montreal, QC, Canada (G.T.); and Clinical Trial Service Unit and Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (R.C.).
Bernard
B
Prendergast
From Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (B.J.C., R.C.T., J.G.); British Heart Foundation Centre of Research Excellence, University of Oxford, United Kingdom (B.J.C.); Kolling Institute, University of Sydney, Australia (S.C.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (S.C.); Guy's and St Thomas' Hospitals, London, United Kingdom (B.P.); Department of Medicine, McGill University, Montreal, QC, Canada (J.C.E., G.T.); McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada (M.L.); Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute, Montreal, QC, Canada (G.T.); and Clinical Trial Service Unit and Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (R.C.).
Jane
J
Green
From Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (B.J.C., R.C.T., J.G.); British Heart Foundation Centre of Research Excellence, University of Oxford, United Kingdom (B.J.C.); Kolling Institute, University of Sydney, Australia (S.C.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (S.C.); Guy's and St Thomas' Hospitals, London, United Kingdom (B.P.); Department of Medicine, McGill University, Montreal, QC, Canada (J.C.E., G.T.); McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada (M.L.); Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute, Montreal, QC, Canada (G.T.); and Clinical Trial Service Unit and Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (R.C.).
James C
JC
Engert
From Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (B.J.C., R.C.T., J.G.); British Heart Foundation Centre of Research Excellence, University of Oxford, United Kingdom (B.J.C.); Kolling Institute, University of Sydney, Australia (S.C.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (S.C.); Guy's and St Thomas' Hospitals, London, United Kingdom (B.P.); Department of Medicine, McGill University, Montreal, QC, Canada (J.C.E., G.T.); McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada (M.L.); Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute, Montreal, QC, Canada (G.T.); and Clinical Trial Service Unit and Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (R.C.).
Mark
M
Lathrop
From Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (B.J.C., R.C.T., J.G.); British Heart Foundation Centre of Research Excellence, University of Oxford, United Kingdom (B.J.C.); Kolling Institute, University of Sydney, Australia (S.C.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (S.C.); Guy's and St Thomas' Hospitals, London, United Kingdom (B.P.); Department of Medicine, McGill University, Montreal, QC, Canada (J.C.E., G.T.); McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada (M.L.); Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute, Montreal, QC, Canada (G.T.); and Clinical Trial Service Unit and Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (R.C.).
George
G
Thanassoulis
From Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (B.J.C., R.C.T., J.G.); British Heart Foundation Centre of Research Excellence, University of Oxford, United Kingdom (B.J.C.); Kolling Institute, University of Sydney, Australia (S.C.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (S.C.); Guy's and St Thomas' Hospitals, London, United Kingdom (B.P.); Department of Medicine, McGill University, Montreal, QC, Canada (J.C.E., G.T.); McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada (M.L.); Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute, Montreal, QC, Canada (G.T.); and Clinical Trial Service Unit and Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (R.C.).
Robert
R
Clarke
D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D015810:Linkage Disequilibrium; D017270:Lipoprotein(a) / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors
D017270:Lipoprotein(a)
aortic valve stenosis; genetic association studies; genetics; lipoproteins; meta-analysis