Emergence of norovirus GII.2 and its novel recombination during the gastroenteritis outbreak in Japanese children in mid-2016.
In mid-2016, norovirus GII.2 emerged as a major cause of gastroenteritis outbreak in Japan with overall detection rate of 56.3% of norovirus cases. The differences in ORF1 and ORF2 of some norovirus GII were observed. Inter-subtype recombinants GII.Pe/GII.2, GII.P16/GII.2 and GII.P17/GII.2 were detected. Three amino acid substitutions were noted at P2 antigenic site of GII.P16/GII.2 recombinants. Furthermore, this study revealed that the current immunochromatographic kit available in Japan could be used effectively for the detection of recent GII.2 genotype.
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
Aksara
A
Thongprachum
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan; Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Shoko
S
Okitsu
Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Pattara
P
Khamrin
Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Niwat
N
Maneekarn
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
Satoshi
S
Hayakawa
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan; Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: ushijima-hiroshi@jcom.home.ne.jp.
Hiroshi
H
Ushijima
D019943:Amino Acid Substitution; D017250:Caliciviridae Infections / Q000453:epidemiology* / Q000635:transmission / Q000821:virology; D002648:Child; D002846:Chromatography, Affinity; D004196:Disease Outbreaks; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000453:epidemiology* / Q000821:virology; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D029322:Norovirus / Q000145:classification / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D010802:Phylogeny; D011995:Recombination, Genetic; D014764:Viral Proteins / Q000235:genetics* / Q000276:immunology
D014764:Viral Proteins
Gastroenteritis; Japan; Norovirus; Outbreak; Recombinant