Calcifying giant cell cardiomyopathy: a possible new entity: Images in Cardiovascular Pathology.
We demonstrated an extremely unusual case of an 83-year-old male's sudden death secondary to characteristic myocardial necrosis and fibrosis with calcification and multinucleated giant cells infiltration, possibly due to sepsis and Stage IV pulmonary pleomorphic carcinoma-induced cachexia after postmortem study. We propose that this calcifying giant cell cardiomyopathy (CGC) would be a new entity especially from the pathological viewpoints and should be considered in the classification of noninfectious myocarditis. Further prospective studies are needed to validate the presence and significance of CGC and the association with any triggers of somewhat microvascular dysfunction and/or toxic agents, after collecting and investigating a larger number of CGC cases examined.
Shared-Use Research Center, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Laboratory of Pathology, Fukuoka Wajiro Hospital, Fukuoka 811-0213, Japan.
Ke-Yong
KY
Wang
Department of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan. Electronic address: sohsuke@m.kufm.kagoshima-u.ac.jp.
Sohsuke
S
Yamada
Department of Pathology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Shohei
S
Shimajiri
Laboratory of Pathology, Fukuoka Wajiro Hospital, Fukuoka 811-0213, Japan.
Ryuji
R
Nakano
Department of Respiratory Surgery, Shin Komonji Hospital, Kitakyushu 800-0057, Japan.
Naoki
N
Yamashita
Department of Respiratory Surgery, Shin Komonji Hospital, Kitakyushu 800-0057, Japan.
Tetsuya
T
So
Department of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan. Electronic address: akit09@m3.kufm.kagoshima-u.ac.jp.
Akihide
A
Tanimoto
D000369:Aged, 80 and over; D001344:Autopsy; D001706:Biopsy; D002114:Calcinosis / Q000473:pathology*; D009202:Cardiomyopathies / Q000473:pathology*; D017809:Fatal Outcome; D005355:Fibrosis; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis
Calcification; Cardiomyopathy; Giant cells