BiparametricversusMultiparametric MRI with Non-endorectal Coil at 3T in the Detection and Localization of Prostate Cancer.
To assess the sensitivity of biparametric magnetic resonance imaging (bpMRI) with non-endorectal coil in the detection and localization of index (dominant) and non-index lesions in patients suspected of having prostate cancer.



We carried-out a retrospective analysis of multiparametric MRI (mpMRI) of 41 patients who underwent radical prostatectomy. Results of MRI for detection and localization of index and non-index lesions were correlated with those of histology.



No statistically significant difference in size was seen between tumor lesion at histology and index lesion at MRI. In 41 patients, a total of 131 tumors were identified at histology, while bpMRI (T2-weighted and diffusion-weighted MRI) approach detected 181 lesions. bpMRI gave 27.6% false-positives and 3.3% false-negatives. Sensitivity in lesion detection by bpMRI increased with lesion size assuming high values for lesions ≥10 mm. For bpMRI and mpMRI, the sensitivity for detecting index lesions was the same and equal: 100% in the peripheral zone 97.6% and 94.7% in the entire prostate and transitional zone, respectively.



bpMRI can be used alternatively to mpMRI to detect and localize index prostate cancer.
Division of Radiology 2 and Nuclear Medicine, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy michelescialpi1@gmail.com.
Michele
M
Scialpi
Section of Anatomic Pathology and Histology, Department of Surgical and Biomedical Sciences, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy.
Enrico
E
Prosperi
Division of Radiology, San Giuseppe Moscati Hospital, Aversa, Italy.
Alfredo
A
D'Andrea
Department of Urology, University of Modena, Modena, Italy.
Eugenio
E
Martorana
Division of Radiology 2 and Nuclear Medicine, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy.
Corrado
C
Malaspina
Division of Radiology 2 and Nuclear Medicine, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy.
Barbara
B
Palumbo
Division of Radiology 2 and Nuclear Medicine, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy.
Agostino
A
Orlandi
Division of Radiology 2 and Nuclear Medicine, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy.
Giuseppe
G
Falcone
Division of Radiology 2 and Nuclear Medicine, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy.
Michele
M
Milizia
Division of Urology, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy.
Luigi
L
Mearini
Division of Gynaecology, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy.
Maria Cristina
MC
Aisa
Division of Urology, Portogruaro, Venice, Italy.
Pietro
P
Scialpi
Department of Gynaecology and Obstetric Science and Urologic Science, La Sapienza University of Rome, Rome, Italy.
Carlo
C
DE Dominicis
Department of Urology, University of Modena, Modena, Italy.
Giampaolo
G
Bianchi
Section of Anatomic Pathology and Histology, Department of Surgical and Biomedical Sciences, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy.
Angelo
A
Sidoni
D000368:Aged; D019540:Area Under Curve; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D005189:False Positive Reactions; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
D003287:Contrast Media; D017430:Prostate-Specific Antigen
Prostate cancer; biparametric MRI; detection; diffusion-weighted imaging; localization