Dispersive micro solid phase extraction of amantadine, rimantadine and memantine in chicken muscle with magnetic cation exchange polymer.
This study demonstrated a novel dispersive micro solid phase extraction (DMSPE) method for extraction of adamantane drugs (amantadine, rimantadine and memantine) in chicken muscle. The adamantane drugs were extracted from chicken muscle using 1% acidic acetonitrile as extraction solvent. The cleanup of fatty matrices from analytes was achieved by the DMSPE technique using magnetic cation exchange polymer as adsorbent. In this procedure, the experimental parameters and conditions were optimized in detail for the improvement of extraction efficiency. The method showed low limit of detection of 0.03μg/kg and recoveries of the analytes ranged from 87.2% to 109.3% for adamantane drugs. The proposed DMSPE method proved to be simple, effective and suitable for the treatment of adamantane drugs in chicken muscle with a relatively shorter extraction time.
Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
Dawei
D
Chen
Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
Hong
H
Miao
Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China. Electronic address: zhaoyf@cfsa.net.cn.
Yunfeng
Y
Zhao
Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China. Electronic address: wuyongning@cfsa.net.cn.
Yongning
Y
Wu
D000327:Adsorption; D000547:Amantadine / Q000302:isolation & purification*; D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification*; D002412:Cations / Q000737:chemistry; D002645:Chickens / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D015259:Dopamine Agents / Q000302:isolation & purification*; D005506:Food Contamination / Q000032:analysis; D057230:Limit of Detection; D059346:Magnets / Q000737:chemistry; D013058:Mass Spectrometry / Q000379:methods; D008559:Memantine / Q000302:isolation & purification*; D009132:Muscles / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011200:Poultry / Q000378:metabolism; D012299:Rimantadine / Q000302:isolation & purification*; D052616:Solid Phase Extraction / Q000379:methods*
D000998:Antiviral Agents; D002412:Cations; D015259:Dopamine Agents; D011108:Polymers; D012299:Rimantadine; D000547:Amantadine; D008559:Memantine
Adamantane drugs; Chicken muscle; DMSPE method; UHPLC–HRMS