Toward novel antiparasitic formulations: Complexes of Albendazole desmotropes and β-cyclodextrin.
Novel complexes of two different solid forms of Albendazol and β-cyclodextrin were investigated in an attempt to obtain promising candidates for the preparation of alternative matrices used in pharmaceutical oral formulations. The interaction between each form of Albendazol and β-cyclodextrin was studied in solution and solid state, in order to investigate their effect on the solubility and dissolution rate of Albendazol solid forms. The solid supramolecular systems were characterized using a variety of techniques including natural-abundance13C cross-polarization magic-angle-spinning nuclear magnetic resonance, powder X-ray diffraction, Fourier transform-infrared spectroscopy and scanning electron microscopy. The results obtained showed the highest increment of solubility and dissolution rate, in simulated gastric fluid, for the Albendazole II:β-cyclodextrin systems. Thus, these new complexes constitute an interesting alternative for improving the oral bioavailability of Albendazol.
Facultad de Matemática, Astronomía y Física and IFEG (CONICET), Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina.
Ana K
AK
Chattah
Department of Chemistry and the Macromolecular Science and Engineering Program, The University of Michigan, Ann Arbor, MI 48109-1055, United States.
Laura Y
LY
Pfund
Departamento de Farmacia, Facultad de Ciencias Químicas and UNITEFA (CONICET), Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina.
Ariana
A
Zoppi
Departamento de Farmacia, Facultad de Ciencias Químicas and UNITEFA (CONICET), Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina.
Marcela R
MR
Longhi
Departamento de Farmacia, Facultad de Ciencias Químicas and UNITEFA (CONICET), Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina. Electronic address: garneroc@fcq.unc.edu.ar.
Claudia
C
Garnero
D015766:Albendazole / Q000737:chemistry*; D000977:Antiparasitic Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
D000977:Antiparasitic Agents; D047392:beta-Cyclodextrins; D015766:Albendazole
Albendazol; Characterization; Cyclodextrin; Desmotrope; Dissolution; Solubility