Eosinophilic esophagitis phenotypes: Ready for prime time?
Eosinophilic esophagitis (EoE) is one of the most common causes of reflux-like symptoms and feeding problems in children and food impaction and dysphagia in adults with a prevalence of 1:2500. Therapeutic options include diet, use of swallowed corticosteroids, or dilation. In the last several years, recent clinical and translational researches have identified some common and distinctive features, for example, the varying response to diet and medications. As EoE shares some characteristics with both asthma and inflammatory bowel disease, the advances in these fields suggest that various phenotypes may also exist in patients with EoE. Here, we provide a rationale for EoE phenotypes and provide some suggestions for potential phenotypes based on histology, molecular signature, response to therapy or dietary therapy.
Gastrointestinal Eosinophilic Diseases Program, Children's Hospital Colorado, Aurora, CO, USA.|Section of Allergy-Immunology, Children's Hospital Colorado, Aurora, CO, USA.|University of Colorado School of Medicine, Aurora, CO, USA.
Dan
D
Atkins
Gastrointestinal Eosinophilic Diseases Program, Children's Hospital Colorado, Aurora, CO, USA.|University of Colorado School of Medicine, Aurora, CO, USA.|Section of Pediatric Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Children's Hospital Colorado, Aurora, CO, USA.
Glenn T
GT
Furuta
Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.|Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.
Chris A
CA
Liacouras
Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.|Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jonathan M
0000-0002-4658-5353
JM
Spergel
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000818:Animals; D001249:Asthma / Q000175:diagnosis*; D002648:Child; D003680:Deglutition Disorders; D003937:Diagnosis, Differential; D004035:Diet Therapy; D057765:Eosinophilic Esophagitis / Q000175:diagnosis* / Q000628:therapy; D004947:Esophagus / Q000276:immunology*; D001068:Feeding and Eating Disorders; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis*; D010641:Phenotype; D015995:Prevalence
D000305:Adrenal Cortex Hormones
eosinophilic esophagitis; phenotypes; symptom; treatment