Expanding the tetrahydroquinoline pharmacophore.
Tetrahydroquinoline is a privileged scaffold with a large number of biological applications. The tetrahydroquinoline pharmacophore has been expanded to yield 34 compounds. Biological screening of these compounds led to the identification of tetrahydroquinoline as neurotropic agents not reported earlier.
Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research, New Delhi, India.
Navya
N
Goli
Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
Prathama S
PS
Mainkar
Chemical Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
Sudha Sravanti
SS
Kotapalli
Chemical Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
Tejaswini
T
K
Chemical Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research, New Delhi, India.
Ramesh
R
Ummanni
Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research, New Delhi, India. Electronic address: srivaric@iict.res.in.
Srivari
S
Chandrasekhar
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002417:Cattle; D045744:Cell Line, Tumor; D061565:Cycloaddition Reaction; D055808:Drug Discovery; D006801:Humans; D009163:Mycobacterium bovis / Q000187:drug effects; D055495:Neurogenesis / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014380:Tuberculosis, Bovine / Q000188:drug therapy / Q000382:microbiology
D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D011804:Quinolines; D054852:Small Molecule Libraries; C542964:1,2,3,4-tetrahydroquinoline
Neurotropic agents; Povarov reaction; Tetrahydroquinoline