Antimicrobial activity of tigecycline and cefoperazone/sulbactam tested against 18,386 Gram-negative organisms from Europe and the Asia-Pacific region (2013-2014).
A total of 18,386 organisms, including 13,224 Enterobacteriaceae, 3536 Pseudomonas aeruginosa, 1254 Acinetobacter spp., and 372Stenotrophomonas maltophilia were collected from Western Europe (WEU; n=10,021), Eastern Europe (EEU; n=4957), and the Asia-Pacific region (APAC; n=3408 [1052 from China]) in 2013-2014 as part of the SENTRY Antimicrobial Surveillance Program and tested by a reference broth microdilution method for susceptibility against tigecycline, cefoperazone/sulbactam, and comparator agents. Overall, 95.3% of Enterobacteriaceae were susceptible (≤1μg/mL; EUCAST) to tigecycline (MIC50/90, 0.12/1μg/mL) with regional EUCAST susceptibility rates of 94.8-97.8% (98.9-99.6% inhibited at ≤2μg/mL [US FDA]). Among Acinetobacter spp., 66.1% (EEU) and 79.5% (WEU) were inhibited at ≤1μg/mL of tigecycline (94.9% and 97.3% inhibited at ≤2μg/mL; pan-European MIC50/90, 1/2μg/mL). For S. maltophilia, 65.4% (China) to 88.9% (EEU) of the isolates were inhibited at ≤1μg/mL of tigecycline. Cefoperazone/sulbactam inhibited 94.6/83.5/91.5% of Enterobacteriaceae at ≤16μg/mL in WEU/EEU/APAC, respectively.
JMI Laboratories, North Liberty, IA, USA; University of Iowa, Iowa City, IA, USA.
M A
MA
Pfaller
JMI Laboratories, North Liberty, IA, USA.
R K
RK
Flamm
JMI Laboratories, North Liberty, IA, USA.
L R
LR
Duncan
JMI Laboratories, North Liberty, IA, USA.
R E
RE
Mendes
JMI Laboratories, North Liberty, IA, USA.
R N
RN
Jones
JMI Laboratories, North Liberty, IA, USA. Electronic address: helio-sader@jmilabs.com.
H S
HS
Sader
D000150:Acinetobacter / Q000187:drug effects / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001208:Asia; D002438:Cefoperazone / Q000494:pharmacology*; D002681:China; D004359:Drug Therapy, Combination; D004755:Enterobacteriaceae / Q000187:drug effects / Q000302:isolation & purification; D005060:Europe; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification; D020615:Stenotrophomonas maltophilia / Q000187:drug effects / Q000302:isolation & purification; D013407:Sulbactam / Q000494:pharmacology*; D000078304:Tigecycline
D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D002438:Cefoperazone; D008911:Minocycline; D013407:Sulbactam
Acinetobacter spp.; Cefoperazone/sulbactam; China; Enterobacteriaceae; Stenotrophomonas maltophilia; antimicrobial resistance; tigecycline