Improving artificial metalloenzymes' activity by optimizing electron transfer.
While many artificial metalloenzymes have been reported, and are proposed to be highly promising for energy, environmental and medical applications, few could match the turnover rate (TOR) and turnover number (TON) of natural enzymes. Since electron transfer is oftentimes the rate-determining step, optimizing the electron transfer efficiency is an effective approach to significantly enhance artificial enzymes' activity. In this article, we review the recent progress in improving artificial metalloenzymes' activity by optimizing electron transfer.
Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China. jwang@ibp.ac.cn.
Cheng
C
Hu
Yang
Y
Yu
Jiangyun
J
Wang
D004579:Electron Transport; D008667:Metalloproteins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular
D008667:Metalloproteins