Disseminated punctate keratoderma: a rare case report and review of the literature.
We report a rare case of a 53-year-old womanpresenting with diffuse, late-onset disseminatedhyperkeratotic papules. Biopsy showed massivehyperkeratosis overlying a crateriform epidermaldepression and hypergranulosis with mild epidermalhyperplasia. There was no parakeratosis, cornoidlamella, or dyskeratosis. Based on the clinical findingsand histopathological features, a diagnosis ofdisseminated punctate keratoderma was made. Thisis a rare subtype of palmoplantar keratoderma, whichhas a putative increased risk of malignancy. This casereport emphasizes the importance of identifyingthe clinical and histological presentation of this rarecondition; referral of the patient for age-appropriatemalignancy screening is appropriate. We also presenta concise review of treatment options.
Eseosa
E
Asemota
Alina
A
Markova
Jonathan
J
Ho
Boston University School of Medicine, Boston, Massachusetts. mkl20@bu.edu.
Michael K
MK
Lichtman
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000145:classification / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D007641:Keratolytic Agents / Q000627:therapeutic use; D008875:Middle Aged; D011701:PUVA Therapy; D012176:Retinoids / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D007641:Keratolytic Agents; D012176:Retinoids