The influence of gravity on regional lung blood flow in humans: SPECT in the upright and head-down posture.
Previous studies in humans have shown that gravity has little influence on the distribution of lung blood flow while changing posture from supine to prone. This study aimed to evaluate the maximal influence of posture by comparison of regional lung blood flow in the upright and head-down posture in 8 healthy volunteers, using a tilt table. Regional lung blood flow was marked by intravenous injection of macroaggregates of human albumin labeled with99mTc or113mIn, in the upright and head-down posture, respectively, during tidal breathing. Both radiotracers remain fixed in the lung after administration. The distribution of radioactivity was mapped using quantitative single photon emission computed tomography (SPECT) corrected for attenuation and scatter. All images were obtained supine during tidal breathing. A shift from upright to the head-down posture caused a clear redistribution of blood flow from basal to apical regions. We conclude that posture plays a role for the distribution of lung blood flow in upright humans, and that the influence of posture, and thereby gravity, is much greater in the upright and head-down posture than in horizontal postures. However, the results of the study demonstrate that lung structure is the main determinant of regional blood flow and gravity is a secondary contributor to the distribution of lung blood flow in the upright and head-down positions.NEW & NOTEWORTHYUsing a dual-isotope quantitative SPECT method, we demonstrated that although a shift in posture redistributes blood flow in the direction of gravity, the results are also consistent with lung structure being a greater determinant of regional blood flow than gravity. To our knowledge, this is the first study to use modern imaging methods to quantify the shift in regional lung blood flow in humans at a change between the upright and head-down postures.
Function Perioperative Medicine and Intensive Care, Karolinska University Hospital Solna, Stockholm, Sweden; malin.ax@sll.se.|Department of Physiology and Pharmacology, Section of Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden; and.
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Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.
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Sanchez-Crespo
Function Perioperative Medicine and Intensive Care, Karolinska University Hospital Solna, Stockholm, Sweden.|Department of Physiology and Pharmacology, Section of Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden; and.
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Lindahl
Function Perioperative Medicine and Intensive Care, Karolinska University Hospital Solna, Stockholm, Sweden.|Department of Physiology and Pharmacology, Section of Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden; and.
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Mure
Function Perioperative Medicine and Intensive Care, Karolinska University Hospital Solna, Stockholm, Sweden.|Department of Physiology and Pharmacology, Section of Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden; and.
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Petersson
D000328:Adult; D005260:Female; D006112:Gravitation; D018475:Head-Down Tilt / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008168:Lung / Q000098:blood supply*; D008297:Male; D016684:Prone Position / Q000502:physiology*; D011652:Pulmonary Circulation / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology; D016683:Supine Position / Q000502:physiology*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D055815:Young Adult
indium; inverse upright; perfusion; technetium; tilt table