Relationship between serum adiponectin and bone mineral density in male patients with obstructive sleep apnea syndrome.
OBJECTIVE
Obstructive sleep apnea syndrome (OSAS) is reported to have an association with bone mineral density (BMD). However, the underlying mechanism is far from clear. The aim of this study was to investigate the relationship between OSAS, bone turnover markers, and BMD and to evaluate the effect of adiponectin on BMD in patients with OSAS.


METHODS
Seventy-one male patients with OSAS and 13 male control subjects were enrolled in this study. Serum adiponectin, calcium, phosphorus, 25-hydroxyvitamin-D3, β-isomerized form C-terminal telopeptide of type I collagen, osteocalcin, and procollagen type 1 N-propeptide were measured in all subjects, and BMD was evaluated by dual-energy X-ray absorptiometry (DEXA) in the lumbar spine (L1-L4), the femoral neck, and the hip total.


RESULTS
No statistically significant differences were found between the studied groups in terms of demographic data and bone turnover markers. Serum adiponectin significantly decreased with the aggravation of OSAS. Compared with subjects without OSAS, those with OSAS had a higher hip total BMD and t scores (p = 0.027 and p = 0.028). The significant negative association was found between serum adiponectin levels and hip total BMD. After adjusting for confounders, adiponectin as well as oxygen desaturation index (ODI) significantly predicted the hip total BMD (β = -0.232, p = 0.005 and β = 0.226, p = 0.037).


CONCLUSIONS
In male subjects, the presence of obstructive sleep apnea syndrome is associated with higher bone mineral density of the hip. These findings suggest that serum adiponectin may be an underlying mediator for BMD in OSAS.
Department of Respiratory Medicine, Fujian Provincial Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, People's Republic of China, 350005.
Dong-Dong
DD
Chen
Department of Respiratory Medicine, Fujian Provincial Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, People's Republic of China, 350005.
Jie-Feng
JF
Huang
Department of Respiratory Medicine, Fujian Provincial Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, People's Republic of China, 350005. chang4e@126.com.
Qi-Chang
QC
Lin
Department of Respiratory Medicine, Fujian Provincial Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, People's Republic of China, 350005.
Gong-Ping
GP
Chen
Department of Respiratory Medicine, Fujian Provincial Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, People's Republic of China, 350005.
Jian-Ming
JM
Zhao
D015502:Absorptiometry, Photon; D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015519:Bone Density / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000503:physiopathology*; D013223:Statistics as Topic
D052242:Adiponectin
Adiponectin; Bone mineral density; Bone turnover markers; Obstructive sleep apnea syndrome