Rejuvenation by Therapeutic Elimination of Senescent Cells.
In this issue of Cell, Baar et al. show how FOXO4 protects senescent cell viability by keeping p53 sequestered in nuclear bodies, preventing it from inducing apoptosis. Disrupting this interaction with an all-D amino acid peptide (FOXO4-DRI) restores p53's apoptotic role and ameliorates the consequences of senescence-associated loss of tissue homeostasis.
Division of Molecular Genetics, the Netherlands Cancer Institute, Amsterdam, the Netherlands.
Paul
P
Krimpenfort
Division of Molecular Genetics, the Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: a.berns@nki.nl.
Anton
A
Berns
D017209:Apoptosis; D002470:Cell Survival; D016922:Cellular Senescence; D006801:Humans; D012060:Rejuvenation; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry
D016159:Tumor Suppressor Protein p53