Lupane-type triterpenes and their anti-cancer activities against most common malignant tumors: A review.
In recent times, a great deal of interest has been motivated on plant derived compounds known as nutraceuticals. These compounds exert important beneficial activities that improve people's health status when are consumed regularly, and now they appear as a viable option to explore their possible therapeutic effects against diseases like cancer. Particularly, lupane-type triterpenes have shown great ability to modulate multiple cancer-related signaling pathways and processes, including NF-κB, Wnt/β-catenin, PI3K/Akt, apoptosis, and many other routes related to proliferation or cell death, which are uncontrolled in malignant tumors. These investigations have promotedin vitroandin vivostudies, searching their mechanisms of action; although more research is still needed to prove its potential in human clinical trials. This review focuses on the ability of betulin, betulinic acid and lupeol to show benefits against the most common types of malignant tumors, which are considered a major global threat for public health.
Instituto Tecnológico de Durango, Departamento de Ingenierías Química y Bioquímica, Blvd. Felipe Pescador 1830 Ote., Col Nueva Vizcaya, 34080 Durango, Dgo., México.
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Cháirez-Ramírez
Instituto Tecnológico de Durango, Departamento de Ingenierías Química y Bioquímica, Blvd. Felipe Pescador 1830 Ote., Col Nueva Vizcaya, 34080 Durango, Dgo., México.
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Moreno-Jiménez
Instituto Tecnológico de Durango, Departamento de Ingenierías Química y Bioquímica, Blvd. Felipe Pescador 1830 Ote., Col Nueva Vizcaya, 34080 Durango, Dgo., México.
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González-Laredo
Instituto Tecnológico de Durango, Departamento de Ingenierías Química y Bioquímica, Blvd. Felipe Pescador 1830 Ote., Col Nueva Vizcaya, 34080 Durango, Dgo., México.
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Gallegos-Infante
Instituto Tecnológico de Durango, Departamento de Ingenierías Química y Bioquímica, Blvd. Felipe Pescador 1830 Ote., Col Nueva Vizcaya, 34080 Durango, Dgo., México.
Nuria Elizabeth
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Rocha-Guzmán
betulin; betulinic acid; cancer; lupeol; signaling pathway