Lack of association of mortalin (HSPA9) and other mitochondria-related genes with risk of Parkinson's and Alzheimer's diseases.
We investigated the role of mortalin (HSPA9) and its interaction with other mitochondria-related genes (parkin, PINK1, DJ1, and COQ2) as a risk factor for Parkinson's disease (PD) and Alzheimer's disease (AD) in 500 PD, 400 AD, and 500 control subjects. The HSPA9 variants identified by direct sequencing or its interaction with other genes assessed by genetic risk scores did not show a significant association with PD or AD risk. Our findings did not provide a strong evidence for the role of HAPA9 and its interaction with other mitochondria-related genes as a genetic risk factor for PD or AD.
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address: sjchung@amc.seoul.kr.
Sun Ju
SJ
Chung
Department of Neurology, Bobath Memorial Hospital, Seongnam, South Korea.
Mi-Jung
MJ
Kim
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Ho-Sung
HS
Ryu
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; Department of Neurology, Metro Hospital, Anyang, South Korea.
Juyeon
J
Kim
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Young Jin
YJ
Kim
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Kiju
K
Kim
Department of Neurology, Dongsan Medical Center, Keimyung University, Daegu, South Korea.
Sooyeoun
S
You
Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Seong Yoon
SY
Kim
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Jae-Hong
JH
Lee
D019883:Alkyl and Aryl Transferases / Q000235:genetics; D000544:Alzheimer Disease / Q000235:genetics*; D004843:Epistasis, Genetic / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D014644:Genetic Variation / Q000235:genetics*; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000235:genetics*; D024101:Mitochondrial Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D000071617:Protein Deglycase DJ-1 / Q000235:genetics; D011494:Protein Kinases / Q000235:genetics; D012306:Risk; D012307:Risk Factors; D044767:Ubiquitin-Protein Ligases / Q000235:genetics; D000099202:PTEN-Induced Putative Kinase
D019883:Alkyl and Aryl Transferases; D018840:HSP70 Heat-Shock Proteins; D024101:Mitochondrial Proteins; D000071617:Protein Deglycase DJ-1; D011494:Protein Kinases; D044767:Ubiquitin-Protein Ligases; D000099202:PTEN-Induced Putative Kinase; C492001:HSPA9 protein, human; C111567:parkin protein; C021386:4-hydroxybenzoate polyprenyltransferase; C105131:PARK7 protein, human
Alzheimer's disease; Genetic variation; Mitochondria; Parkinson's disease