In VitroandEx VivoApproaches to Evaluate Next-Generation Tobacco and Non-Tobacco Products on Human Blood Platelets.
Human blood platelets are major hemostatic regulators in the circulation and important in the mediation of chronic inflammation and immunomodulation. They are key elements that promote cardiovascular pathogenesis that leads to atherosclerosis, thrombosis, myocardial infarction, and stroke. New information on tobacco use and platelet dysregulation shows that these highly understudied vascular cells are dysregulated by tobacco smoke. Thus, platelet function studies should be an important consideration for the evaluation of existing and next-generation tobacco and non-tobacco products. Novelin vitroapproaches are being sought to investigate these products and their influence on platelet function. Platelets are ideally suited for product assessment, as robust and novelin vitrotranslational methods are available to assess platelet function. Furthermore, the use of human biological systems has the advantage that risk predictions will better reflect the human condition.
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York.
Sherry L
SL
Spinelli
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York.
Katie L
KL
Lannan
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry , Rochester, New York.
Shannon G
SG
Loelius
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Richard P
RP
Phipps
cardiovascular disease; in vitro testing; inflammation; nicotine; platelet; tobacco