Twitch mouth pressure for detecting respiratory muscle weakness in suspicion of neuromuscular disorder.
Twitch mouth pressure using magnetic stimulation of the phrenic nerves and an automated inspiratory trigger is a noninvasive, non-volitional assessment of diaphragmatic strength. Our aims were to validate this method in patients with suspected neuromuscular disease, to determine the best inspiratory-trigger pressure threshold, and to evaluate whether twitch mouth pressure decreased the overdiagnosis of muscle weakness frequently observed with noninvasive volitional tests. Maximal inspiratory pressure, sniff nasal pressure, and twitch mouth pressure were measured in 112 patients with restrictive disease and suspected neuromuscular disorder. Esophageal and transdiaphragmatic pressures were measured in 64 of these patients to confirm or infirm inspiratory muscle weakness. Magnetic stimulation was triggered by inspiratory pressures of -1 and -5 cmH2O. The -5 cmH2O trigger produced the best correlation between twitch mouth pressure and twitch esophageal pressure (R2= 0.86; P <0.0001). The best association of noninvasive tests to predict inspiratory muscle weakness was sniff nasal pressure and twitch mouth pressure. Below-normal maximal inspiratory pressure and sniff nasal pressure values suggesting inspiratory muscle weakness were found in 63/112 patients. Only 52 of these 63 patients also had abnormal twitch mouth pressure. In conclusion twitch mouth pressure measurement is a simple, noninvasive, nonvolitional technique which may help to select patients with suspected neuromuscular disorder for invasive inspiratory-muscle investigation.
INSERM UMR 1179 - Université de Versailles Saint Quentin en Yvelines, Montigny-le-Bretonneux, France; Centro de Fisioterapia e Reabilitação - Hospital Universitário de Brasília, Universidade de Brasília, Brasilia, Brazil.
Dante Brasil
DB
Santos
INSERM UMR 955, Equipe 13 - Faculté de Médecine, Créteil, Paris, France.
Gilbert
G
Desmarais
CIC 1429 - INSERM - APHP, Hôpital Raymond Poincaré, Garches, France.
Line
L
Falaize
Service de Réanimation, APHP - Hôpital Raymond Poincaré, Garches, France.
Adam
A
Ogna
Physiologie - Explorations Fonctionnelles, APHP, Hôpital Raymond Poincaré, Garches, France.
Sandrine
S
Cognet
INSERM UMR 955, Equipe 13 - Faculté de Médecine, Créteil, Paris, France.
Bruno
B
Louis
CIC 1429 - INSERM - APHP, Hôpital Raymond Poincaré, Garches, France; Service de Réanimation, APHP - Hôpital Raymond Poincaré, Garches, France.
David
D
Orlikowski
INSERM UMR 1179 - Université de Versailles Saint Quentin en Yvelines, Montigny-le-Bretonneux, France; Physiologie - Explorations Fonctionnelles, APHP, Hôpital Raymond Poincaré, Garches, France.
Hélène
H
Prigent
INSERM UMR 1179 - Université de Versailles Saint Quentin en Yvelines, Montigny-le-Bretonneux, France; Physiologie - Explorations Fonctionnelles, APHP, Hôpital Raymond Poincaré, Garches, France. Electronic address: f.lofaso@aphp.fr.
Frédéric
F
Lofaso
D000328:Adult; D003964:Diaphragm / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology; D005260:Female; D006801:Humans; D001239:Inhalation; D008297:Male; D008875:Middle Aged; D009055:Mouth; D018908:Muscle Weakness / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D009468:Neuromuscular Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D010791:Phrenic Nerve / Q000503:physiopathology; D011312:Pressure; D012129:Respiratory Function Tests / Q000379:methods*; D012132:Respiratory Muscles / Q000294:innervation / Q000503:physiopathology*; D012680:Sensitivity and Specificity
Magnetic stimulation; Neuromuscular diseases; Respiratory muscle strength; Twitch mouth pressure