Keeping fat on time: Circadian control of adipose tissue.
Circadian clocks harmonize processes ranging from intracellular biochemistry to whole-body physiology in accordance with the Earth's 24h rotation. These intrinsic oscillators are based on an interlocked transcriptional-translational feedback loop comprised from a set of core clock factors. In addition to maintaining rhythmicity in nearly every cell of the body, these clock factors also mediate tissue specific metabolic functions. In this review, we will explore how the molecular clock shapes the unique features of different adipose depots.
Section for Metabolic Receptology at the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen 2200, Denmark.
Stine
S
Ninel Hansen
Section for Metabolic Receptology at the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen 2200, Denmark.
Julia
J
Peics
Section for Metabolic Receptology at the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen 2200, Denmark.
Zachary
Z
Gerhart-Hines
D000273:Adipose Tissue / Q000502:physiology*; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans
Adipose tissue; Brown, Beige, and white fat; Circadian rhythm; Molecular clock