Clinical management of the homozygous α-thalassemia with unusual mandibular manifestation of hematopoiesis.
Alpha (α)-thalassemias are the most common genetic disorder of hemoglobin (Hb) synthesis, affecting up to 5% of the world's population. These congenital hemolytic anemias induce extramedullary hematopoiesis, including the liver, spleen, sinuses, and the diploic spaces of the skull. Oral health problems in patients with thalassemias are mostly related to a varied degree of facial deformities, malocclusions, and/or dental arch dimensions. We present a case with a 49-year-old man, diagnosed with homozygous α thalassemia that came to the Faculty of Dentistry at the University of Murcia for a dental treatment. It was observed that the patient had an unusual mandibular manifestation of hematopoiesis.
Docent Unit of Special Patients and Gerodontology, School of Dentistry, University of Murcia, Hospital Morales Meseguer, Avda. Marqués de los Vélez s/n, Murcia 30007, Spain.
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Ruiz-Roca
Docent Unit of Special Patients and Gerodontology, School of Dentistry, University of Murcia, Hospital Morales Meseguer, Avda. Marqués de los Vélez s/n, Murcia 30007, Spain.
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Oñate-Sánchez
Docent Unit of Special Patients and Gerodontology, School of Dentistry, University of Murcia, Hospital Morales Meseguer, Avda. Marqués de los Vélez s/n, Murcia 30007, Spain.
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Urrutia-Rodríguez
Docent Unit of Special Patients and Gerodontology, School of Dentistry, University of Murcia, Hospital Morales Meseguer, Avda. Marqués de los Vélez s/n, Murcia 30007, Spain.
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Martínez-Izquierdo
Docent Unit of Special Patients and Gerodontology, School of Dentistry, University of Murcia, Hospital Morales Meseguer, Avda. Marqués de los Vélez s/n, Murcia 30007, Spain.
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Mengual-Pujante
Docent Unit of Special Patients and Gerodontology, School of Dentistry, University of Murcia, Hospital Morales Meseguer, Avda. Marqués de los Vélez s/n, Murcia 30007, Spain. Electronic address: fcojavier@um.es.
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Rodríguez-Lozano
D006411:Hematopoiesis, Extramedullary / Q000235:genetics; D006720:Homozygote; D006801:Humans; D008297:Male; D008334:Mandible / Q000502:physiology; D008336:Mandibular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008875:Middle Aged; D014077:Tooth Erosion / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D014081:Tooth Extraction; D017085:alpha-Thalassemia / Q000150:complications / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*
Alpha-thalassemia; Dental management; Extramedullary hematopoiesis; Mandibular manifestation