Advances in the Pathology and Molecular Biology of Sarcomas and the Impact on Treatment.
Sarcomas are a complex group of childhood and adult neoplasms with differentiation towards mesenchymal tissues that can occur at almost every anatomic site. Although pathologically diverse, they frequently show similar clinical presentations and radiological findings, such that correct histopathologic diagnosis, utilising the appropriate ancillary immunohistochemical and molecular techniques, underpins their management. This article gives an overview of the pathology, coupled with recent advances in molecular biology, of a selection of soft tissue sarcomas from a clinicopathological perspective, discussing histopathological diagnosis with developments in molecular diagnosis and the incorporation of these findings into diagnostic practice and current and potential targeted treatments.
Sarcoma Unit, Royal Marsden Hospital, London, UK.
K
K
Thway
Sarcoma Unit, Royal Marsden Hospital, London, UK.
J
J
Noujaim
Sarcoma Unit, Royal Marsden Hospital, London, UK.
R L
RL
Jones
Sarcoma Unit, Royal Marsden Hospital, London, UK. Electronic address: cyril.fisher@rmh.nhs.uk.
C
C
Fisher
D000328:Adult; D006801:Humans; D012509:Sarcoma / Q000473:pathology* / Q000628:therapy*
Molecular pathology; soft tissue sarcoma; targeted therapy