Pigmented lesion of the nipple - a clinicopathological challenge.
Differential diagnoses of pigmented lesions of the nipple include melanocytic nevus, melanosis of the nipple, seborrheic keratosis, pigmented basal cell carcinoma, melanoma and Paget disease. The histologic exam with appropriate immunohistochemistry is a fundamental tool to achieve a correct diagnosis. We present a patient with a pigmented lesion of her right nipple revealing mammary Paget disease and elucidate diagnostic obstacles and prognostic importance of early breast cancer detection.
Serviço de Dermatologia e Venereologia, Centro Hospitalar de São João EPE, Porto, Portugal. juliavide@gmail.com.
Júlia
J
Vide
Artur
A
César
Pedro
P
Rodrigues Pereira
Filomena
F
Azevdo
D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D053552:Keratin-7 / Q000378:metabolism; D058950:Melanoma-Specific Antigens / Q000378:metabolism; D009558:Nipples; D010144:Paget's Disease, Mammary / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D009418:S100 Proteins / Q000378:metabolism; D058951:gp100 Melanoma Antigen
D053552:Keratin-7; D058950:Melanoma-Specific Antigens; C548637:PMEL protein, human; D009418:S100 Proteins; D058951:gp100 Melanoma Antigen