Association of cytotoxic T-lymphocyte antigen 4 +49A/G gene polymorphism with acute rejection risk in renal transplantation.
The conclusions on the association between cytotoxic T-lymphocyte antigen 4 (CTLA4) +49A/G gene polymorphism and acute rejection risk in renal transplantation are still debated. This meta-analysis was performed to update the association between CTLA4 +49A/G and acute rejection risk in renal transplantation. The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method. Fourteen reports were included into this meta-analysis for the association of CTLA4 A/G gene polymorphism and acute rejection risk in renal transplantation, consisting of 962 acute rejection patients and 2084 non-acute rejection controls. The association between CTLA4 G allele/GG genotype and acute rejection risk in renal transplantation was found in this meta-analysis (G allele: OR=1.21, 95% CI: 1.03-1.44, P=.02; GG genotype: OR=1.37, 95% CI: 1.10-1.69, P=.004). However, the AA genotype was not associated with acute rejection risk in renal transplantation. In conclusion, CTLA4 G allele/GG genotype is associated with the acute rejection risk in renal transplantation.
Department of Emergency, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Chun-Hua
CH
Yang
Department of Critical Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xue-Xia
XX
Chen
Department of Critical Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Li
L
Chen
Department of Critical Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Dong-Hua
DH
Zheng
Department of Critical Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Qiong-Shan
QS
Liu
Department of Critical Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Wen-Feng
WF
Xie
D014408:Biomarkers, Tumor / Q000235:genetics*; D060908:CTLA-4 Antigen / Q000235:genetics*; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation; D015233:Models, Statistical; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors
D014408:Biomarkers, Tumor; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human
A/G gene polymorphism; acute rejection in renal transplantation; cytotoxic T-lymphocyte antigen 4 (CTLA4); meta-analysis