Pneumonia.
Neonatal pneumonia may occur in isolation or as one component of a larger infectious process. Bacteria, viruses, fungi, and parasites are all potential causes of neonatal pneumonia, and may be transmitted vertically from the mother or acquired from the postnatal environment. The patient's age at the time of disease onset may help narrow the differential diagnosis, as different pathogens are associated with congenital, early-onset, and late-onset pneumonia. Supportive care and rationally selected antimicrobial therapy are the mainstays of treatment for neonatal pneumonia. The challenges involved in microbiological testing of the lower airways may prevent definitive identification of a causative organism. In this case, secondary data must guide selection of empiric therapy, and the response to treatment must be closely monitored.
Columbia University, Department of Pediatrics, Division of Neonatal-Perinatal Medicine, NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.
Thomas A
TA
Hooven
Columbia University, Department of Pediatrics, Division of Neonatal-Perinatal Medicine, NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. Electronic address: rap32@cumc.columbia.edu.
Richard A
RA
Polin
D056704:Adaptive Immunity; D003131:Combined Modality Therapy / Q000009:adverse effects / Q000639:trends; D003428:Cross Infection / Q000517:prevention & control; D019317:Evidence-Based Medicine; D006801:Humans; D007113:Immunity, Innate; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D011014:Pneumonia / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D053717:Pneumonia, Ventilator-Associated / Q000517:prevention & control; D017410:Practice Guidelines as Topic; D012307:Risk Factors
Immunity; Infection; Multidrug resistance; Pulmonary; TORCH infection; Ventilator-associated pneumonia