Embarking on a Chemical Space Odyssey.
The chemical space explored in drug discovery programs is restricted by a narrow reaction toolkit and the frequent failure of even these reactions with polar and functionalized substrates. Recently, high-throughput reaction optimization has been integrated into discovery workflows, thereby increasing the value of specific reaction classes in the toolkit. It is likely that high-throughput experimentation will enable expansion of the synthetic chemistry that is widely exploited in discovery, thereby increasing innovation in medicinal chemistry.
School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds , Leeds, LS2 9JT, U.K.
Shiao Y
SY
Chow
School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds , Leeds, LS2 9JT, U.K.
Adam
A
Nelson
D055808:Drug Discovery; D013329:Structure-Activity Relationship