Non-Hodgkin lymphoma in South East Asia: An analysis of the histopathology, clinical features, and survival from Thailand.
Systemic reports on the descriptive epidemiology of non-Hodgkin lymphoma (NHL) from Southeast Asia are scarce. A nationwide multi-institutional registry was conducted to compare the histopathology, clinical features, and survival of Thai adult patients with NHL using large registries, especially those from Far East Asia (FEA). Using a web-based registry system, 13 major medical centers from the 4 geographic regions of Thailand prospectively collected, from 2007 to 2014, the diagnostic pathology, according to the World Health Organization classification, 2008, clinical features and survival of 4056 patients who were newly diagnosed with NHL. The median age of the patients was 56 years (range, 16-99 years). The male-to-female ratio was 1.3:1. From the total of 4056 patients, T/NK-cell lymphoma (TNKCL) accounted for 12.6% of cases, and 5.1% had human immunodeficiency virus-associated lymphoma. The four leading histological subtypes were diffuse large B-cell lymphoma, not otherwise specified (58.1%); follicular lymphoma (5.6%); extranodal mucosa-associated lymphoid tissue lymphoma (5.2%); and peripheral T-cell lymphoma, not otherwise specified (4.0%). With a median follow-up duration of 46.1 months, the median overall survival of B-cell NHL was significantly longer than that of patients with TNKCL (76.5 vs 28.8 months, P = .0001). Compared to FEA, the Thai registry had an approximately one-half lower relative frequency of TNKCL; the prevalence of extranodal mucosa-associated lymphoid tissue lymphoma was much lower than in Korea, and the frequency of extranodal TNKCL, nasal type, was strikingly low compared to China. It is concluded that while the median age of Thai patients with NHL was approximately a decade younger than for Caucasians, the long-term survival rates for most histological subtypes were comparable. While the histological distribution generally complied with the characteristic Asian features, some differences from FEA were observed.
Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn Universit, Bangkok, Thailand.
Tanin
http://orcid.org/0000-0003-2687-3611
T
Intragumtornchai
Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn Universit, Bangkok, Thailand.
Udomsak
U
Bunworasate
Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn Universit, Bangkok, Thailand.
Kitsada
K
Wudhikarn
Division of Hematology, Department of Medicine, Faculty of Medicine, Prince of Songkhla University, Songkhla, Thailand.
Arnuparp
A
Lekhakula
Division of Hematology, Department of Medicine, Faculty of Medicine, Prince of Songkhla University, Songkhla, Thailand.
Jakrawadi
J
Julamanee
Division of Hematology, Department of Medicine, Faculty of Medicine, Kon Kaen University, Kon Kaen, Thailand.
Kanchana
K
Chansung
Division of Hematology, Department of Medicine, Faculty of Medicine, Kon Kaen University, Kon Kaen, Thailand.
Chittima
C
Sirijerachai
Division of Hematology, Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Lalita
L
Norasetthada
Division of Hematology, Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Weerasak
W
Nawarawong
Division of Hematology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Archrob
A
Khuhapinant
Division of Hematology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Noppadol
N
Siritanaratanakul
Division of Hematology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.
Tontanai
T
Numbenjapon
Division of Hematology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.
Kannadit
K
Prayongratana
Division of Hematology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Suporn
S
Chuncharunee
Division of Hematology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pimjai
P
Niparuck
Division of Hematology, Department of Medicine, Rajvithi Hospital, Bangkok, Thailand.
Tawatchai
T
Suwanban
Division of Hematology, Department of Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Nongluk
N
Kanitsap
Division of Hematology, Department of Medicine, Kon Kaen Hospital, Kon Kaen, Thailand.
Somchai
S
Wongkhantee
Division of Hematology, Bangkok Metropolitan Administration Medical College, Bangkok, Thailand.
Rutchanid
R
Pornvipavee
Division of Hematology, Faculty of Medicine, Naresuan University, Pittsanulok, Thailand.
Peerapon
P
Wong
Division of Hematology, Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Nakohn Nayok, Thailand.
Nisa
N
Makruasi
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Pongsak
P
Wannakrairot
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Thamathorn
T
Assanasen
Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Sanya
S
Sukpanichnant
Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Paisarn
P
Boonsakan
Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Wasana
W
Kanoksil
Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Charin
C
Ya-In
Department of Pathology, Faculty of Medicine, Prince of Songkhla University, Songkhla, Thailand.
Kanita
K
Kayasut
Department of Pathology, Faculty of Medicine, Prince of Songkhla University, Songkhla, Thailand.
Winyu
W
Mitranun
Departmentof Pathology, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Naree
N
Warnnissorn
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001210:Asia, Southeastern; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D013785:Thailand; D055815:Young Adult
Thailand; descriptive epidemiology; non-Hodgkin lymphoma; pathology; survival