Correlation in histological subtypes with high resolution computed tomography signatures of early stage lung adenocarcinoma.
BACKGROUND
Uncertainty remains on the association between image characteristics of the nodules in computed tomography (CT) scans and lung adenocarcinoma histopathologic subtypes. We aimed to estimate the correlation between preoperative high resolution computed tomography (HRCT) scan and postoperative histopathology of stage IA lung adenocarcinoma in East Asian Chinese population.


METHODS
We retrospectively reviewed the clinical records and HRCT images of 190 patients (106 female and 84 male) with resected, preoperatively untreated stage IA adenocarcinomas. The relationship between image characteristics of nodules at preoperative HRCT and their histological subtypes after resection were analyzed. The one-way ANOVA, chi-square test and logistic regression were used for analysis.


RESULTS
In 190 patients with stage IA lung adenocarcinoma, median tumor diameter was significantly lower in lepidic predominant invasive adenocarcinoma (LPA) (15.96±6.95 mm). Univariate analysis revealed that ground-glass opacity (GGO) proportion (P<0.001), margin (P<0.001), border definition (P=0.015), pleural retraction (P<0.001) and enhancement (P<0.001) had statistically significant differences in four histological subtypes. The multivariate analysis referenced for lepidic group which indicated that GGO proportion and pleural retraction were independent associated with acinar group (RR=4.221, 95% CI: 1.770-10.066, P=0.001; RR=0.380, 95% CI: 0.158-0.916, P=0.031, respectively). Male and whose nodule margin with spiculation or lobulation were prone to papillary predominant invasive adenocarcinoma (PPA) (RR=0.288, 95% CI: 0.090-0.920, P=0.036; RR=0.250, 95% CI: 0.070-0.887, P=0.032, respectively). GGO proportion and nodule margin were independent related factors in solid predominant invasive adenocarcinoma (SPA) (RR=13.338, 95% CI: 2.974-59.811, P=0.001; RR=0.097, 95% CI: 0.016-0.606, P=0.013, respectively).


CONCLUSIONS
Nodules with spiculation or lobulation and less GGO proportion are determinants of histological subtypes with poor prognosis in stage IA lung adenocarcinoma patients according to the 2011 histologic IASLC/ATS/ERS classification.
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medical, Nanjing 210002, China;; Nanjing University Institute of Respiratory Medicine, Nanjing 210002, China.
Yingying
Y
Miao
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medical, Nanjing 210002, China;; Nanjing University Institute of Respiratory Medicine, Nanjing 210002, China.
Jianya
J
Zhang
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medical, Nanjing 210002, China;; Nanjing University Institute of Respiratory Medicine, Nanjing 210002, China.
Jiawei
J
Zou
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medical, Nanjing 210002, China;; Nanjing University Institute of Respiratory Medicine, Nanjing 210002, China.
Qingqing
Q
Zhu
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medical, Nanjing 210002, China;; Nanjing University Institute of Respiratory Medicine, Nanjing 210002, China.
Tangfeng
T
Lv
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medical, Nanjing 210002, China;; Nanjing University Institute of Respiratory Medicine, Nanjing 210002, China.
Yong
Y
Song
High resolution computed tomography (HRCT); ground-glass opacity (GGO); histopathology; lung adenocarcinoma