Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma JaponicumCercariae.
A novel three-component supramolecular hydrogel based on riboflavin, melamine and amino acid derivatives were constructed for controlled release of pesticides, Niclosamide derivatives. The formation of hydrogel may be attributed to self-assemble via hydrogen bonding and π-π interaction, which have been researched via scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectra. The rheological experiments showed that the hydrogel materials and drug-loaded hydrogel all demonstrated good mechanical strength and high stability. Further experimental results indicated that the drug-loaded hydrogels show large drug loadings, long-term release time and relatively higher efficiency to anti-cercariae in the water environment.
Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China. liyb@gnnu.cn.
Yibao
Y
Li
Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China. zhul@gnnu.cn.
Lei
L
Zhu
Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China. fanyl@gnnu.cn.
Yulan
Y
Fan
Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China. liyy@gnnu.cn.
Yayun
Y
Li
Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China. chenglx@gnnu.cn.
Linxiu
L
Cheng
Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China. liuw@gnnu.cn.
Wei
W
Liu
Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China. wuyq@gnnu.cn.
Xun
X
Li
Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China. fanxl2013@gnnu.cn.
Xiaolin
X
Fan
anti-cercariae; drug release; hydrogel; long-term release time