The relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects.
We previously reported that a shallow circumpapillary retinal nerve fiber layer (cpRNFL) peak angle as measured by optical coherence tomography (OCT) suggests the temporal retina is stretched around the optic disc from the papillo-macular bundle (Yamashita T et al. Investigative Ophthalmol Vis Sci 2013). The purpose of the current study was to investigate the relationship between CorvisST tonometry (CST) corneal measurements, axial length (AL) and the change in OCT-measured cpRNFL peak angle, in young healthy subjects. OCT and CST measurements were carried out in 97 eyes of 97 young healthy volunteers. The relationship between cpRNFL peak angle and 12 CST parameters, adjusted for AL, was investigated using linear modelling. The mean ± standard deviation cpRNFL peak angle of the 97 healthy volunteers was 130.6 ± 25.4 (range: 77.8 to 207.0) degrees. The optimal linear model to explain cpRNFL peak angle (chosen from 216different models) included three CST variables related to the speed and size of energy absorption (namely, A1 time, A1 length and A2 time), in addition to AL. In eyes with longer AL and shorter energy absorption in CST measurement, temporal retina is stretched around the optic disc from the papillo-macular bundle, as suggested by a shallow cpRNFL peak angle.
Department of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Masato
M
Matsuura
Department of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Hiroshi
H
Murata
Department of Ophthalmology, Saneikai Tsukazaki Hospital, 68-1, Waku, Aboshi-ku, Himeji, Hyogo, 671-1227, Japan.
Shunsuke
S
Nakakura
Department of Ophthalmology and Visual Science, Hiroshima University, 1-3-2 Kagamiyama Higashihiroshima, Hiroshima, 739-8511, Japan.
Yoshitaka
Y
Nakao
Department of Ophthalmology Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Takehiro
0000-0001-7801-2317
T
Yamashita
Department of Ophthalmology, The University of Tokyo, Tokyo, Japan.|Department of Orthoptics and Visual Science, School of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan.
Kazunori
K
Hirasawa
Department of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Yuri
0000-0001-6082-0738
Y
Fujino
Department of Ophthalmology and Visual Science, Hiroshima University, 1-3-2 Kagamiyama Higashihiroshima, Hiroshima, 739-8511, Japan.
Yoshiaki
Y
Kiuchi
Department of Ophthalmology, The University of Tokyo, Tokyo, Japan. rasaoka-tky@umin.ac.jp.
Ryo
R
Asaoka
D000328:Adult; D001696:Biomechanical Phenomena; D003315:Cornea / Q000033:anatomy & histology* / Q000294:innervation / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009412:Nerve Fibers; D011446:Prospective Studies; D012160:Retina / Q000033:anatomy & histology* / Q000502:physiology*; D014065:Tonometry, Ocular; D055815:Young Adult