Clinical Application of Ambient Ionization Mass Spectrometry.
Ambient ionization allows mass spectrometry analysis directly on the sample surface under atmospheric pressure with almost zero sample pretreatment. Since the development of desorption electrospray ionization (DESI) in 2004, many other ambient ionization techniques were developed. Due to their simplicity and low operation cost, rapid and on-site clinical mass spectrometry analysis becomes real. In this review, we will highlight some of the most widely used ambient ionization mass spectrometry approaches and their applications in clinical study.
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital.
Li-Hua
LH
Li
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital.
Hua-Yi
HY
Hsieh
Department of Chemistry, National Taiwan University.
Cheng-Chih
CC
Hsu
ambient ionization; clinical mass spectrometry; point-of-care-test