Prevalence of Human Herpesvirus-8 and BK Polyoma Virus Infections in End-stage Renal Disease and the Influence of Renal Transplantation.
Viral infections lead to significant morbidity and mortality in kidney transplant recipients. We evaluated 49 kidney transplant recipients for human herpesvirus 8 (HHV-8) and BK polyomavirus infections in conjunction with data obtained from 43 donors. The seroprevalence of HHV-8 was 6.9% in donors and 12.2% in recipients. HHV-8 DNA was detected below the limit of quantification (<5000 copies/mL) in a recipient with HHV-8 seropositivity at the pretransplant period and was undetectable at month 3 after transplantation. Transient viruria with BK polyomavirus was recorded in 10.2% of recipients without viremia. Multiple factors contribute to viral reactivation, particularly immunosuppressive treatment. Reduction in maintenance immunosuppression seems beneficial in terms of viral reactivation. At our center, routine use of valganciclovir for antiviral prophylaxis may be effective for the prevention of HHV-8 reactivation.
Department of Nephrology, Istanbul School of Medicine, Istanbul, Turkey. Electronic address: turkmenaydin@yahoo.com.
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Turkmen
Department of Microbiology, Istanbul School of Medicine, Istanbul, Turkey.
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O
Guven
Department of Microbiology, Istanbul School of Medicine, Istanbul, Turkey.
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S
Mese
Department of Microbiology, Istanbul School of Medicine, Istanbul, Turkey.
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Agacfidan
Department of Nephrology and Transplantation, Sisli Memorial Hospital, Istanbul, Turkey.
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Yelken
Department of Microbiology, Istanbul School of Medicine, Istanbul, Turkey.
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Onel
Department of Nephrology, Istanbul School of Medicine, Istanbul, Turkey.
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Caliskan
Department of Microbiology, Istanbul School of Medicine, Istanbul, Turkey.
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Celik
Department of Microbiology, Istanbul School of Medicine, Istanbul, Turkey.
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Turkoglu
Department of Nephrology and Transplantation, Sisli Memorial Hospital, Istanbul, Turkey.
B
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Kocak
D001739:BK Virus / Q000235:genetics; D006566:Herpesviridae Infections / Q000453:epidemiology*; D019288:Herpesvirus 8, Human; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery / Q000821:virology*; D016030:Kidney Transplantation; D027601:Polyomavirus Infections / Q000453:epidemiology*; D015995:Prevalence; D016036:Seroepidemiologic Studies