The role of vasopressin and the vasopressin type V1a receptor agonist selepressin in septic shock.
Septic shock remains one of the major causes of morbidity and mortality in the critically ill. Despite early goal therapy and administration of cathecholaminergic agents, up to 30% of patients succumb to the disease. In this manuscript, we first summarize the standard of care of patients with septic shock and current guidelines. We review the physiologic role of vasopressin and its role in septic shock management. We then review the most up-to-date evidence on the potential role of V1a receptor agonists such as Selepressin, in septic shock. Exciting new trials are being completed in order to elucidate the role of V1a receptor agonists as potential first-line vasopressor alternatives in the therapy of circulatory shock in septic patients.
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX, USA; Division of Maternal Fetal Medicine, Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA. Electronic address: afsaad@utmb.edu.
Antonio F
AF
Saad
Department of Anaesthesia, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Critical Care Research Group, The Prince Charles Hospital and The University of Queensland, Brisbane, Qld, Australia; Department of Anaesthesiology and Intensive Care Medicine, Philipps University, Marburg, Germany. Electronic address: m.maybauer@uq.edu.au.
Marc O
MO
Maybauer
D016638:Critical Illness; D006801:Humans; D017483:Receptors, Vasopressin / Q000819:agonists*; D012772:Shock, Septic / Q000188:drug therapy*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014667:Vasopressins / Q000008:administration & dosage / Q000627:therapeutic use*
D017483:Receptors, Vasopressin; D014662:Vasoconstrictor Agents; D014667:Vasopressins
Catecholamine; FE201258; Norepinephrine; Sepsis; Terlipressin