Microbiological Characteristics and Clinical Outcomes of Acinetobacter spp. Endophthalmitis with the First Reported Case of Acinetobacter haemolyticus Endophthalmitis.
OBJECTIVE
To present the microbiological details and clinical outcomes of Acinetobacter spp. endophthalmitis with the first reported case of A. haemolyticus.


METHODS
A retrospective study of microbiologically proven Acinetobacter spp. endophthalmitis was carried out from 2010 to 2015. The data collected included age, type of endophthalmitis, best-corrected visual acuity (BCVA), species involved, and antibiotic susceptibility pattern. The primary outcomes measured were anatomical outcomes in terms of globe integrity and functional outcome as BCVA at last follow-up.


RESULTS
Eleven patients out of 3004 patients who underwent surgery for endophthalmitis were due to Acinetobacter spp. Seven cases (63.6%) were both smear and culture positive; there were two cases (18%) each of A. haemolyticus and A. baumanii. Four cases (36%) were only culture positive with negative smear. Three cases (27.2%) were polymicrobial. Ten cases (91%) were susceptible to amikacin and nine (82%) to ciprofloxacin. Six (54.5%) were resistant to ceftazidime. Mean logMAR BCVA improved to 1.8 (20/1330) from an initial 2.5 (20/6839). Pthisis bulbi was seen in two cases (18%).


CONCLUSIONS
Even though the outcomes of Acinetobacter spp. endophthalmitis are modest to poor, outcomes following intervention are relatively good for A. haemolyticus. These cases have good susceptibility to amikacin, but are often resistant to ceftazidime.
a Kannuri Santhamma Centre for Vitreoretinal Diseases, L. V. Prasad Eye Institute , Hyderabad , India.
Mahima
M
Jhingan
a Kannuri Santhamma Centre for Vitreoretinal Diseases, L. V. Prasad Eye Institute , Hyderabad , India.
Divya
D
Balakrishnan
a Kannuri Santhamma Centre for Vitreoretinal Diseases, L. V. Prasad Eye Institute , Hyderabad , India.
Padmaja Kumari
PK
Rani
a Kannuri Santhamma Centre for Vitreoretinal Diseases, L. V. Prasad Eye Institute , Hyderabad , India.
Mudit
M
Tyagi
b Jhaveri Microbiology Centre, L.V. Prasad Marg, Banjara Hills , Hyderabad , Telangana , India.
Joveeta
J
Joseph
D000150:Acinetobacter / Q000302:isolation & purification*; D000151:Acinetobacter Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012189:Retrospective Studies; D014792:Visual Acuity; D014822:Vitreous Body / Q000382:microbiology*
D000900:Anti-Bacterial Agents
Amikacin; VITEK; antibiotic susceptibility; ceftazidime resistance; visual outcomes