Hyperthermia by electromagnetic fields to enhanced clinical results in oncology.
Confining treatment to the tumor to improve therapeutic outcome and reduce toxicity, is a hot issue in cancer research. Hyperthermia is recognized as a strong sensitizer for radiotherapy and chemotherapy enhancing tumor control without increasing toxicity. Today's electromagnetic hyperthermia systems heat large tissue volumes with limited ability to selectively heat the tumor. Fortunately, tremendous improvements in 3-dimensional electromagnetic & temperature modelling provide an exciting opportunity to design advanced multi-element electromagnetic applicator systems. Together with feedback control using MR non-invasive thermometry and smart E-field sensors, this paves the way for selective tumor heating and potentially prescription of a thermal dose. A technological advanced hyperthermia system, with guaranteed delivery of high quality hyperthermia lowers the threshold for newcomers to apply hyperthermia. Combined with recent proof that hyperthermia blocks DNA repair and new, exciting, ways for controlled drug delivery using temperature sensitive liposome encapsulated drugs, this is expected to increase interest of the medical community in hyperthermia.
Gerard C
GC
van Rhoon
Maarten M
MM
Paulides
Jeannette M L
JM
van Holthe
Martine
M
Franckena
D002986:Clinical Trials as Topic; D004574:Electromagnetic Fields; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008872:Microwaves; D009369:Neoplasms / Q000628:therapy*; D013696:Temperature