Objective 3D surface evaluation of intracranial electrophysiologic correlates of cerebral glucose metabolic abnormalities in children with focal epilepsy.
To determine the spatial relationship between 2-deoxy-2[18F]fluoro-D-glucose (FDG) metabolic and intracranial electrophysiological abnormalities in children undergoing two-stage epilepsy surgery, statistical parametric mapping (SPM) was used to correlate hypo- and hypermetabolic cortical regions with ictal and interictal electrocorticography (ECoG) changes mapped onto the brain surface. Preoperative FDG-PET scans of 37 children with intractable epilepsy (31 with non-localizing MRI) were compared with age-matched pseudo-normal pediatric control PET data. Hypo-/hypermetabolic maps were transformed to 3D-MRI brain surface to compare the locations of metabolic changes with electrode coordinates of the ECoG-defined seizure onset zone (SOZ) and interictal spiking. While hypometabolic clusters showed a good agreement with the SOZ on the lobar level (sensitivity/specificity = 0.74/0.64), detailed surface-distance analysis demonstrated that large portions of ECoG-defined SOZ and interictal spiking area were located at least 3 cm beyond hypometabolic regions with the same statistical threshold (sensitivity/specificity = 0.18-0.25/0.94-0.90 for overlap 3-cm distance); for a lower threshold, sensitivity for SOZ at 3 cm increased to 0.39 with a modest compromise of specificity. Performance of FDG-PET SPM was slightly better in children with smaller as compared with widespread SOZ. The results demonstrate that SPM utilizing age-matched pseudocontrols can reliably detect the lobe of seizure onset. However, the spatial mismatch between metabolic and EEG epileptiform abnormalities indicates that a more complete SOZ detection could be achieved by extending intracranial electrode coverage at least 3 cm beyond the metabolic abnormality. Considering that the extent of feasible electrode coverage is limited, localization information from other modalities is particularly important to optimize grid coverage in cases of large hypometabolic cortex. Hum Brain Mapp 38:3098-3112, 2017. © 2017 Wiley Periodicals, Inc.
Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, Detroit, Michigan.|Translational Imaging Laboratory, PET Center, Children's Hospital of Michigan, Detroit, Michigan.
Jeong-Won
0000-0003-4498-0939
JW
Jeong
Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, Detroit, Michigan.
Eishi
0000-0001-8391-4067
E
Asano
Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, Detroit, Michigan.|Translational Imaging Laboratory, PET Center, Children's Hospital of Michigan, Detroit, Michigan.
Vinod
V
Kumar Pilli
Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, Detroit, Michigan.
Yasuo
Y
Nakai
Department of Neurology, Nemours DuPont Hospital for Children, Wilmington, Delaware.|Thomas Jefferson University School of Medicine, Philadelphia, Pennysylvania.
Harry T
HT
Chugani
Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, Detroit, Michigan.|Translational Imaging Laboratory, PET Center, Children's Hospital of Michigan, Detroit, Michigan.
Csaba
C
Juhász
D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000379:methods; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000601:surgery; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007223:Infant; D008297:Male; D049268:Positron-Emission Tomography; D018709:Statistics, Nonparametric
D019788:Fluorodeoxyglucose F18; D005947:Glucose
FDG PET; SPM; electrocorticography; epilepsy surgery; pediatric epilepsy; seizure onset