Autobiographical memory loss following a right prefrontal lobe tumour resection: a case report and review of the literature.
BACKGROUND
The right prefrontal lobe has not traditionally been considered eloquent brain. Resection of tumours within this region does not typically lead to permanent functional impairment. In this report, we highlight the case of a patient who developed autobiographical memory loss following an uncomplicated resection of a right prefrontal tumour.


METHODS
A previously fit and well 15-year old presented with a persistent right-sided headache. An MRI demonstrated an expanded right mid-frontal gyrus with changes consistent with a low-grade tumour. The patient underwent a right-sided craniotomy and resection of the lesion which was confirmed as a WHO grade II diffuse astrocytoma. Postoperatively, the patient reported profound retrograde amnesia for a range of memory components, in particular autobiographical memory and semantic memory. Postoperative imaging showed a good resection margin with no evidence of underlying brain injury. Over an 18-month period, the patient showed no improvement in autobiographical memory; however, significant relearning of semantic knowledge took place and her academic performance was found to be in line with expectations for her age.


CONCLUSIONS
In this report, we discuss a case and review the literature on the role of the right prefrontal cortex in memory and caution on the perception of right prefrontal non-eloquence.
Royal Hospital for Sick Children, 9 Sciennes Rd, Edinburgh, EH9 1LF, UK. aabjamjoom@gmail.com.
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Jamjoom
Royal Hospital for Sick Children, 9 Sciennes Rd, Edinburgh, EH9 1LF, UK.
P
P
Gallo
Royal Hospital for Sick Children, 9 Sciennes Rd, Edinburgh, EH9 1LF, UK.
J
J
Kandasamy
Royal Hospital for Sick Children, 9 Sciennes Rd, Edinburgh, EH9 1LF, UK.
J
J
Phillips
Royal Hospital for Sick Children, 9 Sciennes Rd, Edinburgh, EH9 1LF, UK.
D
D
Sokol
D000293:Adolescent; D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000601:surgery*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000000981:diagnostic imaging / Q000209:etiology*; D061212:Memory, Episodic; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000601:surgery*
Astrocytoma; Episodic memory; Memory loss; Right prefrontal lobe