Fine-needle aspiration of metastatic melanoma presenting as bilateral breast cysts.
Melanoma is the second most common non-hematopoietic malignancy after carcinomas to metastasize to the breast and often appears as a well-circumscribed, dense nodule on imaging. Although metastatic lesions presenting as bilateral cysts have been reported, this presentation is not common and may mimic benign breast cysts. We present a challenging case of metastatic melanoma presenting as bilateral breast cysts with spindled cytomorphology in a patient with a history of mammary carcinoma. Discordance between the spindled cytomorphology and the morphology of the core biopsy, which was similar to the patient's primary breast cancer, allowed for entertainment of other tumors and disease processes. Confirmatory immunostaining of the cytology material with HMB-45 was important to establish the diagnosis of metastatic melanoma. Diagn. Cytopathol. 2017;45:446-451. © 2017 Wiley Periodicals, Inc.
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Casey M
http://orcid.org/0000-0002-8822-5655
CM
Inouye
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.|Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ashley
A
Cimino-Mathews
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
David
D
Eisner
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Dorothy L
DL
Rosenthal
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Christopher J
CJ
VandenBussche
D014408:Biomarkers, Tumor / Q000235:genetics*; D062005:Biopsy, Large-Core Needle; D047688:Breast Cyst / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000556:secondary; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D058965:MART-1 Antigen / Q000235:genetics; D008545:Melanoma / Q000175:diagnosis* / Q000235:genetics / Q000556:secondary; D058950:Melanoma-Specific Antigens / Q000235:genetics; D008875:Middle Aged; D009418:S100 Proteins / Q000235:genetics; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D058951:gp100 Melanoma Antigen
D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; D058950:Melanoma-Specific Antigens; C548637:PMEL protein, human; D009418:S100 Proteins; D058951:gp100 Melanoma Antigen
breast; fine needle aspiration; melanoma