Some Observations on PPI Therapy for Bleeding Ulcer.
Proton pump inhibitor (PPI) therapy improves some outcomes after peptic ulcer bleeding. Recent meta-analyses have consistently found reduced rates of rebleeding and surgical intervention but there has been some discordance about effects on overall mortality. In general, more impressive results have been reported from trials conducted in Asia than elsewhere. PPI treatment for ulcer bleeding is not a substitute for appropriate endoscopic hemostatic treatment.
Dr. Leontiadis is Consultant Gastroenterologist and Senior Lecturer in Internal Medicine/Gastroenterology, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece. Dr. Howden is Professor of Medicine, Division of Gastroenterology, Northwestern University Feinberg School of Medicine and Attending Physician, Northwestern Memorial Hospital, Chicago, Ill.
Grigoris I
GI
Leontiadis
Dr. Leontiadis is Consultant Gastroenterologist and Senior Lecturer in Internal Medicine/Gastroenterology, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece. Dr. Howden is Professor of Medicine, Division of Gastroenterology, Northwestern University Feinberg School of Medicine and Attending Physician, Northwestern Memorial Hospital, Chicago, Ill.
Colin W
CW
Howden
Ulcer bleeding; meta-analysis; proton pump inhibitor