Suicide attempt in mental disorders (MeDi): Association with 5-HTT, IL-10 and TNF-alpha polymorphisms.
Mental disorders (MeDi) and suicide attempts (SA) are influenced by environmental and genetic factors. Genetic polymorphism studies have identified some candidate genes for suicidal behaviour in people with MeDi.



To evaluate MeDi and SA in relation to the presence of rs2020933 (5-HTT), rs1800871 (IL-10) and rs1800629 (TNF-α) polymorphisms.



A questionnaire for identification and general data, a brief quality of life assessment (WHOQOL-brief), the scale of suicide ideation by Beck and the MINI International Neuropsychiatric Interview were used in this study. DNA was obtained using buccal mucosa swab samples, and genotyping was performed using real-time polymerase chain reaction. A total of 306 patients were assessed with MeDi; 161 patients had MeDi and a history of SA, and 145 patients had MeDi and no history of SA. The study had 175 subjects in the control group.



The TNF-α rs1800629 -308A/G genotype was significantly associated with function as a protection factor in the control group compared with MeDi without SA. The TNF-α rs1800629 -308G allele appeared as risk factor for MeDi compared to the control group, for female gender. Additionally, the -308A/G + A/A genotype appeared as protection factor for the control group compared to the group with MeDi. For TNF-α, the -308G allele appeared as risk factor for the number of SA (1 time) compared to the control group.



The IL-10 (rs1800871) and 5-HTT (rs2020933) SNPs were considered to have inadequate statistical power. The rs1800629 (TNF-α) polymorphism may be associated with MeDi without SA, MeDi in females and the number of SA (1 time) in the studied group.
Doctor in Mental Health at Institute of Psychiatry, Federal University of Rio de Janeiro, Federal University of Alagoas, Arapiraca, Alagoas, Brazil. Electronic address: veronica.ufal.arapiraca@gmail.com.
Verônica
V
de Medeiros Alves
Master in Health Sciences at Institute of Biological Sciences of Federal University of Alagoas, Arapiraca, Alagoas, Brazil.
Aline Cristine Pereira
ACP
E Silva
PhD in Biotechnology in Health, Renorbio, Post- Graduate Program in Health Sciences, Federal University of Alagoas, Arapiraca, Alagoas, Brazil.
Elaine Virgínia Martins
EVM
de Souza
Student Residence in Mental Health and Psychiatry, State University of Health Sciences of Alagoas, Maceió, Alagoas, Brazil.
Leilane Camila Ferreira
LCF
de Lima Francisco
Student of Biological Sciences, Federal University of Alagoas, Arapiraca, Alagoas, Brazil.
Edilson Leite
EL
de Moura
Doctor in Psychiatry at Institute of Psychiatry, Federal University of Rio de Janeiro, Federal University of Alagoas, Maceió, Alagoas, Brazil.
Valfrido Leão
VL
de-Melo-Neto
Postdoc in the Laboratory of Physiology of Respiration at Institute of Biophysics Carlos Chagas Filho, Panic & Respiration Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro, National Institute for Translational Medicine (INCT-TM), Rio de Janeiro, Brazil.
Antonio E
AE
Nardi
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D001523:Mental Disorders / Q000145:classification / Q000235:genetics* / Q000523:psychology*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life / Q000523:psychology; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013406:Suicide, Attempted / Q000523:psychology*; D011795:Surveys and Questionnaires; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
C508609:IL10 protein, human; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
5-HTT; IL-10; Polymorphism; Suicide attempt; TNF-α