Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy.
The design and development of multifunctional nanoplatforms for biomedical applications still remains to be challenging. This review reports the recent advances in aqueous-phase synthesis of iron oxide nanoparticles (Fe3O4NPs) and their composites for magnetic resonance (MR) imaging and photothermal therapy of cancer. Water dispersible and colloidally stable Fe3O4NPs synthesized via controlled coprecipitation route, hydrothermal route and mild reduction route are introduced. Some of key strategies to improve the r2relaxivity of Fe3O4NPs and to enhance their uptake by cancer cells are discussed in detail. These aqueous-phase synthetic methods can also be applied to prepare Fe3O4NP-based composites for dual-mode molecular imaging applications. More interestingly, aqueous-phase synthesized Fe3O4NPs are able to be fabricated as multifunctional theranostic agents for multi-mode imaging and photothermal therapy of cancer. This review will provide some meaningful information for the design and development of various Fe3O4NP-based multifunctional nanoplatforms for cancer diagnosis and therapy.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China.
Jingchao
J
Li
College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
Shige
S
Wang
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China; CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal. Electronic address: xshi@dhu.edu.cn.
Xiangyang
X
Shi
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China. Electronic address: mwshen@dhu.edu.cn.
Mingwu
M
Shen
D000818:Animals; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D003287:Contrast Media / Q000008:administration & dosage / Q000138:chemical synthesis*; D052203:Ferrosoferric Oxide / Q000008:administration & dosage / Q000138:chemical synthesis*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D015552:Injections, Intralesional; D028022:Low-Level Light Therapy / Q000379:methods; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D051379:Mice; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D000068936:Theranostic Nanomedicine / Q000379:methods*; D014867:Water / Q000737:chemistry; D023041:Xenograft Model Antitumor Assays
D003287:Contrast Media; D058185:Magnetite Nanoparticles; D014867:Water; D052203:Ferrosoferric Oxide
Aqueous-phase synthesis; Iron oxide nanoparticles; Molecular imaging; Photothermal therapy; r(2) relaxivity