Functional oligopeptide as a novel strategy for drug delivery.
Oligopeptides, a type of short peptide, which consist of 2-20 amino acids, exhibit a variety of biological functions in drug delivery systems, such as specific targeting, cell penetration, self-assembled capacity and responsiveness to the environment. In this review, we aim to highlight the importance of functional oligopeptides for nanomedical applications and put forward the views on the future development direction of oligopeptide medicines. Oligopeptides have gained wide attentions due to their inherent properties, but the lack of understanding the mechanisms of in vivo transport behavior is the biggest problem and challenge at the present stage. Therefore, it is an important direction for the future clinical research to systematically evaluate its metabolic behavior and safety in vivo.
a Department of Pharmacy , Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine , Nanjing , PR China.
Yujie
Y
Ji
a Department of Pharmacy , Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine , Nanjing , PR China.
Hongzhi
H
Qiao
a Department of Pharmacy , Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine , Nanjing , PR China.
Jiayu
J
He
a Department of Pharmacy , Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine , Nanjing , PR China.
Weidong
W
Li
a Department of Pharmacy , Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine , Nanjing , PR China.
Rui
R
Chen
a Department of Pharmacy , Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine , Nanjing , PR China.
Jingjing
J
Wang
a Department of Pharmacy , Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine , Nanjing , PR China.
Li
L
Wu
b Department of Pharmacy , Anhui University of Chinese Medicine , Anhui , PR China.
Rongfeng
R
Hu
a Department of Pharmacy , Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine , Nanjing , PR China.
Jinao
J
Duan
a Department of Pharmacy , Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine , Nanjing , PR China.
Zhipeng
Z
Chen
D016503:Drug Delivery Systems; D004798:Enzymes / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008027:Light; D009842:Oligopeptides / Q000008:administration & dosage*
D004798:Enzymes; D009842:Oligopeptides
Oligopeptide; functional; self-assemble; stimuli-responsive; targeting