Medical and Interventional Therapy for Spontaneous Vertebral Artery Dissection in the Craniocervical Segment.
Background and Purpose.Spontaneous vertebral artery dissection (SVAD) is an important reason for posterior-circulation-ischemic stroke in the young and middle-aged population. Although some previous reports reveal a favorable outcome with conservative therapy, it is still controversial in the treatment of SVAD in some specific patients. Herein, we present our 10 years of clinical experience for SVAD at this location.Material and Methods.20 patients with 20 SVADs in V2 and V3 segments were retrospectively studied. Clinical manifestations and imageology materials were collected and analyzed. All the patients underwent anticoagulation except for one patient because of contraindication. 14 patients underwent Wingspan stents implantation with general anesthesia.Results.In our sample, ischemia (infarction or transient ischemic attack, TIA) was found in all the patients. Angiographic stenosis and dissection aneurysm were the most common findings in the segments mentioned above. 19 of the patients (95%) got the excellent imageological and clinical outcomes.Conclusions.According to our experience in this group, although anticoagulation is effective in vertebral artery dissection, interventional therapy for SVADs in V2 and/or V3 segments is preferred in some specific patients. Stent with higher radial supporting and flexibility, such as Wingspan stent, is suggested.
Department of Neurosurgery, Shanghai Jiaotong University First People's Hospital, Shanghai 200080, China.
Guiyun
G
Zhang
Department of Neurosurgery, Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Zuoquan
0000-0001-5904-6263
Z
Chen
D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage*; D020520:Brain Infarction / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D012189:Retrospective Studies; D015607:Stents; D020217:Vertebral Artery Dissection / Q000628:therapy*
D000925:Anticoagulants