Recent updates of carbapenem antibiotics.
Carbapenems are among the most commonly used and the most efficient antibiotics since they are relatively resistant to hydrolysis by most β-lactamases, they target penicillin-binding proteins, and generally have broad-spectrum antibacterial effect. In this review, we described the initial discovery and development of carbapenems, chemical characteristics, in vitro/in vivo activities, resistance studies, and clinical investigations for traditional carbapenem antibiotics in the market; imipenem-cilastatin, meropenem, ertapenem, doripenem, biapenem, panipenem/betamipron in addition to newer carbapenems such as razupenem, tebipenem, tomopenem, and sanfetrinem. We focused on the literature published from 2010 to 2016.
College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt. Electronic address: drmelgamal2002@gmail.com.
Mohammed I
MI
El-Gamal
College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates.
Imen
I
Brahim
College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates.
Noorhan
N
Hisham
College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates.
Rand
R
Aladdin
College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates.
Haneen
H
Mohammed
College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates.
Amany
A
Bahaaeldin
D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D015780:Carbapenems / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
D015780:Carbapenems
Antibiotic resistance; Carbapenems; β-lactamases; β-lactams