TIR Axons Apart: Unpredicted NADase Controls Axonal Degeneration.
SARM1 is a key regulator of axonal degeneration. However, SARM1 mechanism of action is not clear. In this issue of Neuron, Essuman et al. (2017) reveal an intrinsic NADase activity in the SARM1-TIR domain that is required for axonal degeneration.
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Ron
R
Goldner
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: avraham.yaron@weizmann.ac.il.
Avraham
A
Yaron
D051186:Armadillo Domain Proteins; D001369:Axons; D003598:Cytoskeletal Proteins; D006801:Humans; D009244:NAD+ Nucleosidase; D009410:Nerve Degeneration; D009474:Neurons; D014855:Wallerian Degeneration
D051186:Armadillo Domain Proteins; D003598:Cytoskeletal Proteins; C435689:SARM1 protein, human; D009244:NAD+ Nucleosidase
NAD; Sarm1; axon degeneration