Hepatotoxicity induced by intragastrically administrated with Gardenia decoction in mice.
The study was to investigate the potential hepatotoxicity of Gardenia decoction induced by intragastrically administrated mice. Mice were randomly divided into four groups. Intragastric administration of the respective treatments was provided continuously for seven days and the body weight was recorded everyday. The activity levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the serum were recorded. In addition, changes in liver morphology and organ coefficients were evaluated. Compared with the mice in the control group, GD increased the activities of ALT and AST in a dose-dependent manner (P < 0.05). However, there were no significant differences in the weight between the GD-treated groups and the control group (P > 0.05). The liver coefficient was significantly higher (P < 0.05) in the mice in the medium- and high-dose GD groups and there were significant pathological changes in the lives. In conclusion, the high-dose GD has the potential to induce hepatotoxicity in mice.
a College of Animal Sciences and Veterinary , Heilongjiang Bayi Agricultural University , Daqing , China.
Yizhe
Y
Cui
a College of Animal Sciences and Veterinary , Heilongjiang Bayi Agricultural University , Daqing , China.
Rui
R
Sun
a College of Animal Sciences and Veterinary , Heilongjiang Bayi Agricultural University , Daqing , China.
Qiuju
Q
Wang
a College of Animal Sciences and Veterinary , Heilongjiang Bayi Agricultural University , Daqing , China.
Mengzhu
M
Wang
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D004333:Drug Administration Routes; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000009:adverse effects*; D032062:Gardenia / Q000737:chemistry*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D008813:Mice, Inbred ICR; D018675:Toxicity Tests / Q000379:methods
D004365:Drugs, Chinese Herbal; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Gardenia; decoction; hepatotoxicity; intragastric administration; mice