Attenuated mTOR Signaling and Enhanced Glucose Homeostasis by Dietary Supplementation with Lotus Seedpod Oligomeric Procyanidins in Streptozotocin (STZ)-Induced Diabetic Mice.
This study investigated the protective role of lotus seedpod oligomeric procyanidins (LSOPC) and synbiotics (Bifidobacterium Bb-12 and xylo-oligosaccharide) against high fat and streptozotocin (STZ)-induced diabetes. Administration of LSOPC or synbiotics had no effect on blood glucose in normal mice. Treatments with LSOPC for 12 weeks markedly reduced blood glucose, FFA, endotoxin, and GHbA1c and improved glucose homeostasis, lipid metabolism, and insulin levels. In addition, administration of LSOPC significantly reversed the increase of mTOR and p66Shcin liver, skeletal muscle, and white adipose tissue (WAT). LSOPC significantly increased glucose uptake and glycolysis in liver, skeletal muscle, and WAT while improving heat generation in brown adipose tissue (BAT) and inhibiting gluconeogenesis and lipogenesis in liver. Furthermore, synbiotics strengthened the improving effect of LSOPC. These findings demonstrated that LSOPC and synbiotics may regulate glucose disposal in peripheral target tissues through the p66Shc-mTOR signaling pathway.
College of Food Science and Technology, Huazhong Agricultural University , Wuhan 430070, China.
Xiaopeng
X
Li
Institute for Farm Products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Science , Wuhan 430064, China.
Yong
Y
Sui
Hubei Collaborative Innovation Center for Industrial Fermentation, Hubei University of Technology , Wuhan 430068, China.
Qian
Q
Wu
College of Food Science and Technology, Huazhong Agricultural University , Wuhan 430070, China.
Bijun
B
Xie
College of Food Science and Technology, Huazhong Agricultural University , Wuhan 430070, China.
Zhida
http://orcid.org/0000-0003-2822-4367
Z
Sun
D000818:Animals; D044946:Biflavonoids / Q000008:administration & dosage*; D001786:Blood Glucose / Q000378:metabolism*; D002392:Catechin / Q000008:administration & dosage*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D019587:Dietary Supplements / Q000032:analysis; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D031653:Nelumbo / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage*; D044945:Proanthocyanidins / Q000008:administration & dosage*; D015398:Signal Transduction / Q000187:drug effects*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
D044946:Biflavonoids; D001786:Blood Glucose; D007328:Insulin; D010936:Plant Extracts; D044945:Proanthocyanidins; C017674:procyanidin; D002392:Catechin; C546843:mTOR protein, mouse; D058570:TOR Serine-Threonine Kinases
glucose homeostasis; lotus seed oligomeric procyanidins; mTOR; synbiotics; type 2 diabetes