The use of rapid and cost-effective blood-based biomarkers in combination with tumour TNM stage for individual head and neck cancer patient treatment selection.
Head and neck (H&N) cancer is an aggressive disease and the incidence has increased in younger population worldwide. Tumour TNM staging is the main basis for treatment decision despite significant variation in clinical outcome. Survival time of these patients has marginally improved during the last 30 years. Various biomarkers with cumbersome analysis, high cost, time consumption and requirement of special laboratory facilities have been investigated. However, none of these biomarkers have been shown to be suitable to use for individual H&N cancer patient treatment selection in the clinic. For practical use in clinical settings, the given biomarkers must be simple to analyse, rapid, cost effective and available in routine laboratories. With this intension, we suggested the combination of standard TNM staging and biomarkers associated with inflammation such as neutrophils, neutrophil to lymphocyte ratio, plasma C-reactive protein or plasma tumour necrosis factor alpha (TNFa) and single-nucleotide polymorphism in TNFa rs1800629 using blood-based analysis. The optimal treatment outcome of H&N cancer by using combination of TNM stage and these blood-based biomarkers for individual patient selection need further investigation.
Division of Medical Diagnostic, Ryhov Hospital, 55322, Jönköping, Sweden. nongnit.lewin@rjl.se.|Department of Clinical and Experimental Medicine, Linköping University, 58185, Linköping, Sweden. nongnit.lewin@rjl.se.
Nongnit
http://orcid.org/0000-0001-6815-4530
N
Laytragoon Lewin
Department of Oncology, Ryhov Hospital, 55322, Jönköping, Sweden.
Freddi
F
Lewin
Division of Medical Diagnostic, Ryhov Hospital, 55322, Jönköping, Sweden.|Department of Clinical and Experimental Medicine, Linköping University, 58185, Linköping, Sweden.
Bengt-Åke
BÅ
Andersson
Division of Medical Diagnostic, Ryhov Hospital, 55322, Jönköping, Sweden.
Sture
S
Löfgren
Swedish Match AB, 11885, Stockholm, Sweden.
Lars Erik
LE
Rutqvist
D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000473:pathology*; D006801:Humans; D009367:Neoplasm Staging; D000077195:Squamous Cell Carcinoma of Head and Neck
D014408:Biomarkers, Tumor
Head and neck cancer; Individualized treatment selection; Inflammation; Single-nucleotide polymorphism