A Review on Ubiquitination of Neurotrophin Receptors: Facts and Perspectives.
Ubiquitination is a reversible post-translational modification involved in a plethora of different physiological functions. Among the substrates that are ubiquitinated, neurotrophin receptors (TrkA, TrkB, TrkC, and p75NTR) have been studied recently. TrkA is the most studied receptor in terms of its ubiquitination, and different E3 ubiquitin ligases and deubiquitinases have been implicated in its ubiquitination, whereas not much is known about the other neurotrophin receptors aside from their ubiquitination. Additional studies are needed that focus on the ubiquitination of TrkB, TrkC, and p75NTRin order to further understand the role of ubiquitination in their physiological and pathological functions. Here we review what is currently known regarding the ubiquitination of neurotrophin receptors and its physiological and pathological relevance.
Department of Cell Biology and Pathology, Institute of Neuroscience Castile & Leon, University of Salamanca, 37007 Salamanca, Spain. juliasanchez@usal.es.
Julia
J
Sánchez-Sánchez
Institute of Biomedical Research of Salamanca, 37007 Salamanca, Spain. arevalojc@usal.es.
Juan Carlos
JC
Arévalo
D000818:Animals; D006801:Humans; D017475:Receptors, Nerve Growth Factor / Q000235:genetics / Q000378:metabolism*; D054875:Ubiquitination
D017475:Receptors, Nerve Growth Factor
Trk receptors; deubiquitination; neurotrophins; p75NTR; ubiquitination