The Relationship between Bone Mineral Density and Estrogen Receptor Positivity in Patients with Breast Cancer.
OBJECTIVE
The effect of estrogen on bone mineral density (BMD) and breast cancer has been known for a long time. The aim of this study was to compare of the BMD of patients with breast cancer and healthy individuals, and to investigate the degree of correlation of estrogen receptor (ER) with BMD.


METHODS
Seventy-one patients with postmenopausal breast cancer and 79 healthy dividuals were included in the study. The patient demographics (age, menopause age, body mass index, number of children, BMD, Z scores, and estrogen status for breast cancer patients) were taken from hospital records.


RESULTS
No significant difference was detected between the case and control groups in lumbar region Z scores (p=0.074). At the femur neck, the control group Z scores was higher than patient group (p=0.002). BMI was higher in the patients with breast cancer (p=0.001). There was no statistically significant correlation between ER positivity, BMD, and BMI in ER-positive patients (p=0.495, p=0.8, p=0.846, respectively). There was no difference between the Z scores when the patients were divided into two groups as ER positive and negative (p=0.156, p=0.335, respectively).


CONCLUSIONS
This study revealed that there is no difference in lumbar region Z scores between patients with breast cancer and heathy controls; however, the Z scores were higher in the femur neck in the control group, and the BMI was lower in the patient group. Tumor ER positivity does not positively affect BMD.
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Zeynep Erdoğan
ZE
İyigün
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Kezban Nur
KN
Pilancı
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Fatmagül Kuşku
FK
Çabuk
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Serkan
S
İlgün
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Çetin
Ç
Ordu
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Tomris
T
Duymaz
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Gül
G
Alço
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Filiz
F
Çelebi
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Dauren
D
Sarsenov
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Filiz
F
İzci
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Alper
A
Öztürk
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Filiz
F
Ağaçayak
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Ülkühan İner
Üİ
Köksal
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Fatma
F
Aktepe
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Yeşim
Y
Eralp
Florence Nightingale Breast Study Group, İstanbul, Turkey.
Vahit
V
Özmen
Breast cancer; body mass index; bone mineral density; estrogen receptor