Relationship between Helicobacter pylori infection and vomiting induced by gastrointestinal cancer chemotherapy.
BACKGROUND
Nausea and vomiting are the most common adverse reactions to chemotherapy.


OBJECTIVE
To discuss the relationship between Helicobacter pylori and chemotherapy-induced nausea and vomiting (CINV).


METHODS
A total of 112 patients with malignant tumours of the gastrointestinal tract was selected. Based on the 14C-urea breath test results, the patients were divided into H. pylori-positive (n = 59) and H. pylori-negative (n = 53) groups. Both groups received prophylactic antiemetic treatment during chemotherapy. The incidence of nausea and vomiting and their effects on the patients' life functions was recorded using the Multinational Association of Supportive Care in Cancer (MASCC) Antiemetic Tool (MAT) and the Functional Living Index Emesis (FLIE) from 0-120 h after chemotherapy. Records of the H. pylori-positive and H. pylori-negative groups were compared.


RESULTS
The rates of nausea and vomiting remission were higher in the H. pylori -negative group than in the H. pylori -positive group. The proportions of no effect in daily life (NIDL) patients in the nausea and vomiting section were 73.4 and 75.5% in the H. pylori -negative group respectively. There was a higher proportion of NIDL patients in the H. pylori -negative group than in the H. pylori -positive group (P < 0.001, P = 0.046). A multivariate unconditional logistic regression analysis was performed, and the results showed that H. pylori infection was a factor affecting the nausea scores on the FLIE (odds ratio = 0.757, 95% confidence interval 0.597-0.960, P = 0.021).


CONCLUSIONS
H. pylori infection in patients with cancer may be a factor that increases CINV.
Department of Medical Oncology, Anhui Provincial Hospital, Hefei, China.
Yiwei
http://orcid.org/0000-0003-1339-4734
Y
Yao
Department of Medical Oncology, Anhui Provincial Hospital, Hefei, China.
Chushu
C
Ji
Department of Medical Oncology, Anhui Provincial Cancer Hospital, Hefei, China.
Yifu
Y
He
Department of Medical Oncology, Anhui Provincial Cancer Hospital, Hefei, China.
Yueyin
Y
Pan
D000368:Aged; D000932:Antiemetics / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000453:epidemiology*; D016481:Helicobacter Infections / Q000188:drug therapy / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014839:Vomiting / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology*
D000932:Antiemetics; D000970:Antineoplastic Agents

FLIE
; Helicobacter pylori; gastrointestinal tumour; nausea; vomiting