Biosynthesis of polyphenol-stabilised nanoparticles and assessment of anti-diabetic activity.
Green synthesis of nanoparticles (NPs) is a major developing field. In this study, we utilised Whitania somnifera leaves as a green source to synthesise platinum (Pt) NPs. Synthesised Pt NPs resulted from controlled synthesis of 12nm spherical particles. The synthesised Pt NPs were subjected to anti-diabetic applications resulting in a significant decrease in plasma glucose levels after injecting the Pt NPs into streptozotocin-induced diabetic rats.
Department of Endocrine, Shanghai Huadong Hospital, Fudan University, Shanghai 200040, People's Republic of China.
Yuanyuan
Y
Li
Department of Pancreatic Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People's Republic of China.
Jiaqiang
J
Zhang
Department of Pancreatic Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People's Republic of China.
Jiangning
J
Gu
Department of Pancreatic Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People's Republic of China; Department of Hepato-Biliary-Pancreatic Surgery, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, People's Republic of China. Electronic address: shichen145@hotmail.com.
Shi
S
Chen
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004355:Drug Stability; D055772:Green Chemistry Technology; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010984:Platinum / Q000737:chemistry; D059808:Polyphenols; D051381:Rats; D019657:Solanaceae / Q000737:chemistry
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D059808:Polyphenols; D010984:Platinum
Anti-diabetic activity; Controlled synthesis; Pt NPs; W. somnifera