Role of Computed Tomography Volumetry in Estimating Liver Weights in Surgical Patients with Hepatic Steatosis.
OBJECTIVE
Our objective was to assess the accuracy of computed tomography volumetry in estimating liver volume in steatotic patients.


METHODS
We divided 641 liver donors (mean age 27 years, 71% male) into 4 groups according to the extent of steatosis on predonation biopsy: with < 5% comprising group 1, 5% to 9% comprising group 2, 10% to 19% comprising group 3, and ≥ 20% comprising group 4. Graft mass estimation error (%) was calculated as follows: [(computed tomography-measured volume minus graft weight)/graft weight] × 100. We obtained estimation errors, intraclass correlation coefficients, and Pearson correlation coefficients across the groups.


RESULTS
Baseline alanine aminotransferase and gammaglutamyltranspeptidase values were signi ficantly correlated with extent of steatosis. Mean graft weight and computed tomography-measured volume were 725.9 g and 741.2 mL. Mean estimation errors were comparable (1.5% for group 1, 2.7% for group 2, 3.0% for group 3, and 3.9% for group 4; P = .77). In multivariate linear regression, estimation error was inversely correlated with high-density lipoprotein cholesterol (P = .008). Overall, there was an excellent agreement between measured volume and actual weight, with intraclass correlation coefficients over 0.85 and Pearson correlation coefficients over 0.70 in all groups (P < .001).


CONCLUSIONS
Preoperative computed tomography volumetry is an accurate tool for estimating volume regardless of the extent of steatosis.
¹Department of Gastroenterology Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine; and ²Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Republic of Korea.
Yeonjung
Y
Ha
Ju Hyun
JH
Shim
Gi-Won
GW
Song
Seon-Ok
SO
Kim
Tae-Yong
TY
Ha
Dong-Hwan
DH
Jung
Kang Mo
KM
Kim
Young-Suk
YS
Lim
Han Chu
HC
Lee
Sung-Gyu
SG
Lee
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D004796:Clinical Enzyme Tests; D005234:Fatty Liver / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D016014:Linear Models; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D015999:Multivariate Analysis; D009929:Organ Size; D011237:Predictive Value of Tests; D011857:Radiographic Image Interpretation, Computer-Assisted; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood
D015415:Biomarkers; D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human; D000410:Alanine Transaminase