Claiming the validity of scientific evidence in post-truth times.
This letter is written in response to a review recently published in the journal. The aim is to highlight a potential methodological limitation common to many studies comparing bipolar patients with few previous episodes versus those with multiple episodes, and in which the results are interpreted as indicating the longitudinal course of the illness.
Bipolar Disorder Program, Institute of Neurosciences, Favaloro University, Gurruchaga 2463, 1º C, 1425, Buenos Aires, Argentina. diejmartino@gmail.com.|National Council of Scientific and Technical Research (CONICET), Buenos Aires, Argentina. diejmartino@gmail.com.|Institute of Cognitive and Translational Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina. diejmartino@gmail.com.
Diego J
DJ
Martino
Bipolar Disorder Program, Institute of Neurosciences, Favaloro University, Gurruchaga 2463, 1º C, 1425, Buenos Aires, Argentina.|National Council of Scientific and Technical Research (CONICET), Buenos Aires, Argentina.
Cecilia
C
Samamé
Bipolar Disorder Program, Institute of Neurosciences, Favaloro University, Gurruchaga 2463, 1º C, 1425, Buenos Aires, Argentina.|Institute of Cognitive and Translational Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
Sergio A
SA
Strejilevich
Bipolar disorder; Neuroprogression; Response to treatment; Staging