Adipocyte-Tumor Cell Metabolic Crosstalk in Breast Cancer.
The tumor stroma is a heterogeneous ecosystem comprising matrix, fibroblasts, and immune cells and has an important role in cancer progression. Adipocytes constitute a major component of breast stroma, and significant emerging evidence demonstrates a reciprocal metabolic adaptation between stromal adipocytes and breast cancer (BC) cells. Recent observations promote a model where adipocytes respond to cancer cell-derived endocrine and paracrine signaling to provide metabolic substrates, which in turn drive enhanced cancer cell proliferation, invasion, and treatment resistance. Further defining the mechanisms that underpin this dynamic interaction between stromal adipocytes and BC cells, especially in the context of obesity, may identify novel therapeutic strategies. These will become increasingly important in addressing the clinical challenges presented by obesity and metabolic syndromes.
Discipline of Physiology, School of Medical Sciences and Bosch Institute, Charles Perkins Centre, University of Sydney, NSW 2006, Australia. Electronic address: andrew.hoy@sydney.edu.au.
Andrew J
AJ
Hoy
Discipline of Physiology, School of Medical Sciences and Bosch Institute, Charles Perkins Centre, University of Sydney, NSW 2006, Australia.
Seher
S
Balaban
School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia; Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Darren N
DN
Saunders
D017667:Adipocytes / Q000378:metabolism* / Q000502:physiology; D001943:Breast Neoplasms / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism*; D008954:Models, Biological; D009765:Obesity / Q000276:immunology / Q000378:metabolism; D017154:Stromal Cells / Q000378:metabolism / Q000502:physiology
adipocyte; breast cancer; fatty acid; metabolism; obesity