Two-year follow-up of patients with septic shock presenting with low HDL: the effect upon acute kidney injury, death and estimated glomerular filtration rate.
BACKGROUND
Sepsis is associated with decreased levels of high-density lipoprotein (HDL) cholesterol. HDL has anti-inflammatory properties, and the use of Apo A-I mimetic peptides is associated with renal function improvement in animal models of sepsis. However, it is not known whether decreased HDL level results in impaired renal function in human sepsis. We investigated whether low levels of HDL conferred an increased risk of sepsis-associated acute kidney injury (AKI) or long-term decreased estimated glomerular filtration rate (eGFR) after sepsis.


METHODS
HDL concentration (mg dL-1) was measured in plasma samples from 180 patients with septic shock at admission to the Emergency Department (ED). We divided the patients using median HDL as a cut-off value and assessed the frequency of sepsis-associated AKI and long-term decreased eGFR after sepsis. Univariate and multivariate analyses were performed.


RESULTS
Patients with low HDL had a significantly greater frequency of KDIGO 2 or 3 sepsis-associated AKI [39/90 (43.3%) vs. 12/90 (13.3%), P < 0.001] and decreased long-term eGFR [24/58 (41.4%) vs. 11/57 (19.3%), P = 0.018] compared to those with high HDL. The adjusted OR for sepsis-associated AKI and decreased eGFR after sepsis in the lower HDL group was 2.80 (95% CI 1.08-7.25, P = 0.033) and 5.45 (95% CI 1.57-18.93, P = 0.008), respectively.


CONCLUSIONS
Low HDL levels during sepsis are associated with increased risk of sepsis-associated AKI, and/or subsequent decreased eGFR. These results suggest that HDL may be involved and/or may be a marker of kidney injury during and after sepsis.
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
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http://orcid.org/0000-0002-6500-2926
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Roveran Genga
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
C
C
Lo
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
M
M
Cirstea
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
G
G
Zhou
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
K R
KR
Walley
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
J A
JA
Russell
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
A
A
Levin
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
J H
JH
Boyd
D058186:Acute Kidney Injury / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D008076:Cholesterol, HDL / Q000172:deficiency; D003404:Creatinine / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012772:Shock, Septic / Q000150:complications* / Q000401:mortality / Q000503:physiopathology
D008076:Cholesterol, HDL; D003404:Creatinine
HDL cholesterol; chronic renal failure; lipoproteins; renal failure; sepsis