18F-NaF PET/CT in Extensive Melorheostosis of the Axial and Appendicular Skeleton With Soft-Tissue Involvement.
Melorheostosis is a rare, nonhereditary, benign, sclerotic bone dysplasia with no sex predilection, typically occurring in late childhood or early adulthood, which can lead to substantial functional morbidity, depending on the sites of involvement. We report on a patient with extensive melorheostosis in the axial and appendicular skeleton, as well as in the soft tissues, who was evaluated with whole-body F-NaF PET/CT scan. All melorheostotic lesions of the skeleton and of the ossified soft-tissue masses demonstrated intensely increased F-NaF activity, suggesting the application of this modality in assessing and monitoring the disease activity.
From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD; †Foundation for Research and Technology Hellas, Institute of Computer Science, Computational Biomedicine Laboratory, Heraklion, Crete, Greece; ‡National Institute of Arthritis and Musculoskeletal and Skin Diseases and §PET Department, Clinical Center, National Institutes of Health, Bethesda, MD; ∥Center for Research in Computer Vision, Electrical and Computer Science Department, University of Central Florida, Orlando, FL; and ¶Department of Radiology, Medical School, University of Crete, Crete, Greece.
Georgios Z
GZ
Papadakis
Smita
S
Jha
Timothy
T
Bhattacharyya
Corina
C
Millo
Tsang-Wei
TW
Tu
Ulas
U
Bagci
Kostas
K
Marias
Apostolos H
AH
Karantanas
Nicholas J
NJ
Patronas
D000368:Aged; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D008557:Melorheostosis / Q000150:complications* / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D012969:Sodium Fluoride; D012983:Soft Tissue Neoplasms / Q000150:complications*; D051598:Whole Body Imaging
D005462:Fluorine Radioisotopes; D012969:Sodium Fluoride