Chemical Composition, Antioxidant, DNA Damage Protective, Cytotoxic and Antibacterial Activities of Cyperus rotundus Rhizomes Essential Oil against Foodborne Pathogens.
Cyperus rotundus L. (Cyperaceae) is a medicinal herb traditionally used to treat various clinical conditions at home. In this study, chemical composition of Cyperus rotundus rhizomes essential oil, and in vitro antioxidant, DNA damage protective and cytotoxic activities as well as antibacterial activity against foodborne pathogens were investigated. Results showed that α-cyperone (38.46%), cyperene (12.84%) and α-selinene (11.66%) were the major components of the essential oil. The essential oil had an excellent antioxidant activity, the protective effect against DNA damage, and cytotoxic effects on the human neuroblastoma SH-SY5Y cell, as well as antibacterial activity against several foodborne pathogens. These biological activities were dose-dependent, increasing with higher dosage in a certain concentration range. The antibacterial effects of essential oil were greater against Gram-positive bacteria as compared to Gram-negative bacteria, and the antibacterial effects were significantly influenced by incubation time and concentration. These results may provide biological evidence for the practical application of the C. rotundus rhizomes essential oil in food and pharmaceutical industries.
School of Life Science, Shanxi Normal University, Linfen City, 041004, China.
Qing-Ping
QP
Hu
School of Life Science, Shanxi Normal University, Linfen City, 041004, China.
Xin-Ming
XM
Cao
School of Food Science, Shanxi Normal University, Linfen City, 041004, China.
Dong-Lin
DL
Hao
School of Food Science, Shanxi Normal University, Linfen City, 041004, China.
Liang-Liang
LL
Zhang
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D045744:Cell Line, Tumor; D029786:Cyperus / Q000737:chemistry*; D004249:DNA Damage; D006801:Humans; D009474:Neurons / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry*; D012486:Salmonella typhimurium / Q000187:drug effects; D012717:Sesquiterpenes / Q000032:analysis; D012762:Shigella dysenteriae / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D016587:Antimutagenic Agents; D000975:Antioxidants; D009822:Oils, Volatile; D012717:Sesquiterpenes; C000606812:cyperene; C539285:selinene