Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses.
Dengue virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are transmitted by mosquitoes of the Aedes genus. During the last several decades, these viruses have been responsible for millions of cases of infection and thousands of deaths worldwide. Therefore, several investigations were conducted over the past few years to find antiviral compounds for the treatment of DENV and CHIKV infections. One attractive strategy is the screening of compounds that target enzymes involved in the replication of both DENV and CHIKV. In this review, we describe advances in the evaluation of natural products targeting the enzymes involved in the replication of these viruses.
Departamento de Biologia Geral, Universidade Federal de Viçosa, Av. P.H. Rolfs, S/N, 36570-900 Viçosa, MG, Brazil. ana.oliveira@ifnmg.edu.br.|Instituto Federal de Educação, Ciência e Tecnologia do Norte de Minas, 39900-000 Almenara, MG, Brazil. ana.oliveira@ifnmg.edu.br.
Ana Flávia Costa da Silveira
AF
Oliveira
Departamento de Química, Universidade Federal de Viçosa, Av. P.H. Rolfs, S/N, 36570-900 Viçosa, MG, Brazil. robsonr.teixeira@ufv.br.
Róbson Ricardo
RR
Teixeira
Departamento de Biologia Geral, Universidade Federal de Viçosa, Av. P.H. Rolfs, S/N, 36570-900 Viçosa, MG, Brazil. andre.oliveira@ifnmg.edu.br.|Instituto Federal de Educação, Ciência e Tecnologia do Norte de Minas, 39900-000 Almenara, MG, Brazil. andre.oliveira@ifnmg.edu.br.
André Silva de
AS
Oliveira
Departamento de Química, Universidade Federal de Viçosa, Av. P.H. Rolfs, S/N, 36570-900 Viçosa, MG, Brazil. anapaulamartins20@hotmail.com.
Ana Paula Martins de
AP
Souza
Departamento de Química, Universidade Federal de Viçosa, Av. P.H. Rolfs, S/N, 36570-900 Viçosa, MG, Brazil. milenelopesdasilva@yahoo.com.br.
Milene Lopes da
ML
Silva
Departamento de Biologia Geral, Universidade Federal de Viçosa, Av. P.H. Rolfs, S/N, 36570-900 Viçosa, MG, Brazil. robsonr.teixeira@ufv.br.
Sérgio Oliveira de
SO
Paula
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D002646:Chikungunya virus / Q000187:drug effects* / Q000201:enzymology* / Q000502:physiology; D003716:Dengue Virus / Q000187:drug effects* / Q000201:enzymology* / Q000502:physiology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D014764:Viral Proteins / Q000037:antagonists & inhibitors; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D001688:Biological Products; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D014764:Viral Proteins
antiviral; chikungunya; dengue; natural products; virus enzymes