Heat-Induced Editing of HPV Genes to Clear Mucocutaneous Warts?
Hyperthermia increases expression of the antiviral cellular factors APOBEC3A and APOBEC3G and induces G-to-A or C-to-T mutations in human papilloma virus cervical cell lines and genital warts. This unexpected effect of heat treatment correlated with regression of genital warts in a subset of patients, including at distant sites, suggesting that this effect may be mediated in part by antiviral as well as immunological mechanisms.
Dermatology and Academic Wound Healing, Division of Infection and Immunity, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK. Electronic address: Piguetv@Cardiff.ac.uk.
Vincent
V
Piguet
D003218:Condylomata Acuminata / Q000235:genetics / Q000628:therapy / Q000821:virology*; D003564:Cytidine Deaminase / Q000235:genetics*; D005260:Female; D015967:Gene Expression Regulation, Viral; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D009154:Mutation; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000235:genetics / Q000628:therapy; D011506:Proteins / Q000235:genetics*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000628:therapy / Q000821:virology
D011506:Proteins; C121399:APOBEC3A protein, human; D003564:Cytidine Deaminase