Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells.
Phaeanthus vietnamensis Bân is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8'R)-9,9'-epoxy-3,5,3',5'-tetramethoxylignan-4,4',7-triol (1), 8α-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-4-acetyl-2-[(E)-(cinnamoyloxy)]-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated BV2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC50values of 15.7 ± 1.2 μm. Compounds 2, 7, and 8 significantly inhibited inflammatory NO production with IC50values ranging from 22.6 to 25.3 μm.
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
Nguyen Xuan
NX
Nhiem
National Institute of Medicinal Materials, 3B Quang Trung, Hoankiem, Hanoi, Vietnam.
Nguyen Trung
NT
Tuong
Hanoi University of Pharmacy, 15 Le Thanh Tong, Hoankiem, Hanoi, Vietnam.
Pham Thanh
PT
Ky
College of Pharmacy, Gachon University, Incheon, 21936, Korea.
Lalita
L
Subedi
College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, 21983, Korea.
Seon Ju
SJ
Park
National Institute of Medicinal Materials, 3B Quang Trung, Hoankiem, Hanoi, Vietnam.
Tran Minh
TM
Ngoc
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
Pham Hai
PH
Yen
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
Bui Huu
BH
Tai
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
Tran Hong
TH
Quang
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
Phan Van
PV
Kiem
College of Pharmacy, Gachon University, Incheon, 21936, Korea.
Sun Yeou
SY
Kim
College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, 21983, Korea.
Seung Hyun
SH
Kim
D000818:Animals; D029061:Annonaceae / Q000737:chemistry* / Q000378:metabolism; D002460:Cell Line; D002942:Circular Dichroism; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D017628:Microglia / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry* / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D017705:Lignans; D010936:Plant Extracts; D012717:Sesquiterpenes; D009569:Nitric Oxide

Phaeanthus vietnamensis
; Annonaceae; Anti-inflammatory activities; Aromandendrane; Lignan; Sesquiterpene