Photoreceptor Cell Injury Starts in the Initial Stage of Vogt-Koyanagi-Harada Disease.
OBJECTIVE
To demonstrate photoreceptor cell injury in Vogt-Koyanagi-Harada (VKH) disease.


METHODS
The SD-OCT and FAF tests of 16 patients diagnosed with VKH disease that was followed up from the initial stage to the convalescent stage were reviewed.


RESULTS
In the initial stage of VKH disease, there was hyperautofluerescence around the macular edema. In the convalescent stage of VKH disease, loss of photoreceptor and injury of RPE have been detected by OCT scan at the same area, which was corresponded with the abnormalities in FAF.


CONCLUSIONS
The VKH disease causes photoreceptor injury starting in the initial stage of the disease.
a Department of Ophthalmology , Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education , Beijing , China.
Ruilin
R
Zhu
a Department of Ophthalmology , Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education , Beijing , China.
Jing
J
Zhang
a Department of Ophthalmology , Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education , Beijing , China.
Lijun
L
Qiao
a Department of Ophthalmology , Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education , Beijing , China.
Yadi
Y
Zhang
a Department of Ophthalmology , Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education , Beijing , China.
Xiaopeng
X
Gu
a Department of Ophthalmology , Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education , Beijing , China.
Liu
L
Yang
D000328:Adult; D000368:Aged; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010786:Photoreceptor Cells / Q000473:pathology*; D055213:Retinal Pigment Epithelium / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications / Q000175:diagnosis*
Fundus autofluorescence; VKH disease; optical coherence tomography; photoreceptor; photoreceptor injury