Feasibility of PET for the management of coronary artery disease: Comparison between CFR and FFR.
Myocardial perfusion imaging using positron emission tomography (PET) allows both qualitative and quantitative measurement. The quantitative myocardial blood flow and coronary flow reserve (CFR) are reliable indices for evaluating functional severity, influenced by both epicardial stenosis and microvascular disease. Fractional flow reserve (FFR) also reflects physiological stenosis, which measures the pressure differences across a coronary artery stenosis during maximum hyperemia. Discordance between CFR and FFR has been noticed in estimating the functional significance of coronary stenosis. In this review, we summarize the feasibility of PET for the management of coronary artery disease compared to FFR.
Department of Nuclear Medicine, Hokkaido University of Graduate School of Medicine, Sapporo, Japan.
Osamu
O
Manabe
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: naya@med.hokudai.ac.jp.
Masanao
M
Naya
Department of Nuclear Medicine, Hokkaido University of Graduate School of Medicine, Sapporo, Japan.
Nagara
N
Tamaki
D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003326:Coronary Circulation; D006801:Humans; D055414:Myocardial Perfusion Imaging; D049268:Positron-Emission Tomography
Coronary artery disease; Coronary flow reserve; Fractional flow reserve; Myocardial blood flow; Positron emission tomography