A Potential of sFasL in Preventing Gland Injury in Sjogren's Syndrome.
Fas and its ligand FasL, members of tumor necrosis factor receptor superfamily, have been implicated in the process of cell apoptosis. FasL consists of two forms, membrane FasL (mFasL) and soluble FasL (sFasL). sFasL can be produced by mFasL cleaved by matrix metalloproteinases (MMP) and also reveals a role for binding to Fas which is expressed on cell surface. Although Fas/FasL axis has been implicated in a variety of diseases, its role in Sjogren's syndrome still remains ill defined. In this study, we investigated the potential of sFasL in the pathogenesis of Sjogren's syndrome (SS). We found that the serum levels of sFasL in SS patients were significantly lower than healthy subjects. Moreover, serum levels of sFasL in patients with mild disease activity were higher than patients with severe disease activity. There is a positive correlation of the serum level of sFasL with uptake index of parotid gland in our expectation. In addition, liver injury involvement in SS patients showed decreased level of sFasL. Furthermore, we here also observed that the protective cytokine IL-10 expression was positively correlated with sFasL expression. Thus, our results here suggest a potential of sFasL in maintaining gland organ homeostasis.
Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China; Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, China.
Jiao
0000-0001-8649-7916
J
Luo
The Chenggong Hospital Affiliated to Xiamen University, Xiamen, Fujian, China.
Ying
Y
Wang
Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China; Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, China.
Bing
B
Yu
Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China; Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, China.
Hongyan
0000-0003-0076-8194
H
Qian
Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China; Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, China.
Yan
0000-0002-4316-8298
Y
He
Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China; Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, China.
Guixiu
0000-0003-4044-3394
G
Shi
D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000235:genetics; D053222:Fas Ligand Protein / Q000097:blood*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis; D008099:Liver / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D020033:Protein Isoforms / Q000097:blood* / Q000235:genetics; D012859:Sjogren's Syndrome / Q000097:blood* / Q000150:complications / Q000235:genetics / Q000473:pathology; D019014:fas Receptor / Q000097:blood*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; C508609:IL10 protein, human; D020033:Protein Isoforms; D019014:fas Receptor; D016753:Interleukin-10