Thymic Carcinoma With Endobronchial Metastasis: A Case Report.
Thymic carcinoma is a rare cancer, accounting for only 1% to 4% of thymic epithelial tumors. Endobronchial metastasis is a rare presentation of these tumors. A 64-year-old man presented with a cough. Lung cancer was suspected because a chest radiograph showed a 7-cm mass in the left pulmonary hilum. Computed tomography showed a mass in the anterior mediastinum and an infiltrate in the upper lobe of the left lung. Bronchoscopy demonstrated bilateral polypoid tumors in the left B bronchus and the right B bronchus. Endobronchial biopsies of both lesions resulted in a diagnosis of squamous cell carcinoma that was positive for c-KIT by immunohistochemical staining. The patient was eventually found to have thymic squamous cell carcinoma with bilateral endobronchial metastases (stage IVb according to the Masaoka-Koga staging system) by diagnostic video-assisted thoracoscopic surgery. He was subsequently treated with platinum-doublet chemotherapy and achieved a partial response for 18.8 months.
Departments of *Thoracic Oncology and Respiratory Medicine †Pathology, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Honkomagome, Bunkyo, Tokyo, Japan.
Makoto
M
Nagamata
Yusuke
Y
Okuma
Yukio
Y
Hosomi
Tsunekazu
T
Hishima
D001984:Bronchial Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D016190:Carboplatin / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013945:Thymoma / Q000000981:diagnostic imaging* / Q000188:drug therapy; D013953:Thymus Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D016896:Treatment Outcome
D016190:Carboplatin