Manganese-Catalyzed N-Formylation of Amines by Methanol Liberating H2: A Catalytic and Mechanistic Study.
The first example of a base metal (manganese) catalyzed acceptorless dehydrogenative coupling of methanol and amines to form formamides is reported herein. The novel pincer complex (iPr-PNHP)Mn(H)(CO)2catalyzes the reaction under mild conditions in the absence of any additives, bases, or hydrogen acceptors. Mechanistic insight based on the observation of an intermediate and DFT calculations is also provided.
Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, 76100, Israel.
Subrata
S
Chakraborty
Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, 76100, Israel.
Urs
0000-0002-8119-9626
U
Gellrich
Chemical Research Support, Weizmann Institute of Science, Rehovot, 76100, Israel.
Yael
Y
Diskin-Posner
Chemical Research Support, Weizmann Institute of Science, Rehovot, 76100, Israel.
Gregory
G
Leitus
Chemical Research Support, Weizmann Institute of Science, Rehovot, 76100, Israel.
Liat
L
Avram
Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, 76100, Israel.
David
0000-0002-2320-0262
D
Milstein
dehydrogenation; formylation; manganese; methanol; pincer complexes