Evaluation of serum zonulin for use as an early predictor for gestational diabetes.
Diet has an important role in regulating intestinal permeability and subsequently the risk for metabolic disorders. In this observational study, we examined whether serum intestinal permeability marker zonulin, could be used as a predictor for gestational diabetes mellitus (GDM). Serum zonulin concentration was measured in early pregnancy in overweight or obese pregnant women (n=88) at risk for developing GDM. Serum zonulin was associated with higher odds of GDM (adjusted OR for 1 ng ml-1increase in zonulin: 1.08, 95% CI: 1.02-1.15; P=0.009), diagnosed by a 2-h 75-g oral glucose tolerance test at late pregnancy. The optimal cutoff value was 43.3 ng ml-1, with sensitivity of 88% (95% CI: 71-100%) and specificity of 47% (95% CI: 33-58%). The area under the ROC-curve was 0.67 (95% CI: 0.54-0.81). Our results show an association between increased early-pregnancy serum zonulin concentration and GDM, suggesting zonulin as a possible predictor for GDM.
Institute of Biomedicine, University of Turku, Turku, Finland.|Functional Foods Forum, University of Turku, Turku, Finland.
K
K
Mokkala
Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, Turku, Finland.
K
K
Tertti
Department of Medicine, Institute of Clinical Medicine, University of Turku and Turku University Hospital, Turku, Finland.
T
T
Rönnemaa
Department of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.
T
T
Vahlberg
Institute of Biomedicine, University of Turku, Turku, Finland.|Functional Foods Forum, University of Turku, Turku, Finland.
K
K
Laitinen
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002772:Cholera Toxin / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005951:Glucose Tolerance Test; D006242:Haptoglobins; D006801:Humans; D009765:Obesity / Q000097:blood; D050177:Overweight / Q000097:blood*; D011247:Pregnancy; D011498:Protein Precursors; D012680:Sensitivity and Specificity
D001786:Blood Glucose; D006242:Haptoglobins; D011498:Protein Precursors; C408043:zonulin; D002772:Cholera Toxin