The Upsides and Downsides of Organelle Interconnectivity.
Interconnectivity and feedback control are hallmarks of biological systems. This includes communication between organelles, which allows them to function and adapt to changing cellular environments. While the specific mechanisms for all communications remain opaque, unraveling the wiring of organelle networks is critical to understand how biological systems are built and why they might collapse, as occurs in aging. A comprehensive understanding of all the routes involved in inter-organelle communication is still lacking, but important themes are beginning to emerge, primarily in budding yeast. These routes are reviewed here in the context of sub-system proteostasis and complex adaptive systems theory.
Calico Life Sciences, South San Francisco, CA 94080, USA. Electronic address: dang@calicolabs.com.
Daniel E
DE
Gottschling
Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden. Electronic address: thomas.nystrom@cmb.gu.se.
Thomas
T
Nyström
D000375:Aging / Q000502:physiology; D000818:Animals; D002455:Cell Division; D006801:Humans; D015388:Organelles / Q000502:physiology*; D011506:Proteins / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000502:physiology; D015398:Signal Transduction
D011506:Proteins
aging; inter-organelle communication; protein quality control; yeast