Mycobacterium goodii endocarditis following mitral valve ring annuloplasty.
BACKGROUND
Mycobacterium goodii is an infrequent human pathogen which has been implicated in prosthesis related infections and penetrating injuries. It is often initially misidentified as a gram-positive rod by clinical microbiologic laboratories and should be considered in the differential diagnosis.


METHODS
We describe here the second reported case of M. goodii endocarditis. Species level identification was performed by 16S rDNA (ribosomal deoxyribonucleic acid) gene sequencing. The patient was successfully treated with mitral valve replacement and a prolonged combination of ciprofloxacin and trimethoprim/sulfamethoxazole.


CONCLUSIONS
Confirmation of the diagnosis utilizing molecular techniques and drug susceptibility testing allowed for successful treatment of this prosthetic infection.
Texas Heart Institute, 6770 Bertner Avenue, Houston, Tx, 77030, USA.
Rohan B
RB
Parikh
Yale School of Medicine, 333 Cedar St, New Haven, CT, 06510, USA. m.grant@yale.edu.
Matthew
M
Grant
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016000:Cluster Analysis; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D017548:Echocardiography, Transesophageal; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D058386:Mitral Valve Annuloplasty / Q000009:adverse effects*; D009161:Mycobacterium / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D013902:Radiography, Thoracic; D012092:Replantation; D017422:Sequence Analysis, DNA; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S
Endocarditis; Gene sequencing; Mycobacterium goodii; Prostheses related infections