Dietary supplementation of thiamine and pyridoxine-loaded vanillic acid-grafted chitosan microspheres enhances growth performance, metabolic and immune responses in experimental rats.
In the present investigation, the effect of dietary supplementation of thiamine and pyridoxine loaded vanillic acid-grafted chitosan microspheres (TPVGC) on growth, metabolic and immune responses in Wistar strain albino rats was studied. Eight experimental groups, namely four groups each for male and female rats were fed with 0, 0.4, 0.8 and 1.6% of TPVGC in the diet. At the end of 45days feeding trials, both male and female rats supplemented with TPVGC had higher weight gain% and specific growth rate than the control groups. Significantly (p<0.05) lower blood glucose level and higher respiratory burst activity were recorded in the treatment groups than the control groups of both male and female rats. Activity of metabolic enzymes (aspartate amino transferase, alanine aminotransferase, alkaline phosphatase and acid phosphatase) and antioxidant enzymes (superoxide dismutase, catalase and glutathione S-transferase) were significantly higher (p<0.05) in the control groups and a decreasing trend in the same was observed with a gradual increase in the inclusion level of TPVGC in the diet of the treatment groups. However, a reverse trend was observed for acetylcholine esterase. It was inferred that dietary supplementation of thiamine and pyridoxine loaded vanillic acid-grafted chitosan enhanced the growth performance, metabolic and immune responses in the animal-model.
ICAR-Central Institute of Fisheries Technology, Willingdon Island, Matsyapuri post, Cochin, 682029, India. Electronic address: tejpal.arun@rediffmail.com.
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Tejpal
ICAR-Central Institute of Fisheries Technology, Willingdon Island, Matsyapuri post, Cochin, 682029, India.
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Chatterjee
ICAR-Central Institute of Fisheries Technology, Willingdon Island, Matsyapuri post, Cochin, 682029, India.
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Elavarasan
ICAR-Central Institute of Fisheries Technology, Willingdon Island, Matsyapuri post, Cochin, 682029, India.
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Lekshmi
ICAR-Central Institute of Fisheries Technology, Willingdon Island, Matsyapuri post, Cochin, 682029, India.
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Anandan
ICAR-Central Institute of Fisheries Technology, Willingdon Island, Matsyapuri post, Cochin, 682029, India.
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Asha
ICAR-Central Institute of Fisheries Technology, Willingdon Island, Matsyapuri post, Cochin, 682029, India.
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Ganesan
ICAR-Central Institute of Fisheries Technology, Willingdon Island, Matsyapuri post, Cochin, 682029, India.
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Mathew
ICAR-Central Institute of Fisheries Technology, Willingdon Island, Matsyapuri post, Cochin, 682029, India.
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Ravishankar
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D048271:Chitosan / Q000737:chemistry*; D019587:Dietary Supplements; D004734:Energy Metabolism / Q000187:drug effects*; D057075:Enzyme Assays; D005260:Female; D056747:Immunomodulation / Q000187:drug effects*; D008297:Male; D008863:Microspheres; D010316:Particle Size; D011736:Pyridoxine / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D016897:Respiratory Burst; D013482:Superoxide Dismutase / Q000378:metabolism; D013831:Thiamine / Q000008:administration & dosage* / Q000737:chemistry; D014641:Vanillic Acid / Q000737:chemistry*
D001786:Blood Glucose; D048271:Chitosan; D002374:Catalase; D013482:Superoxide Dismutase; D014641:Vanillic Acid; D011736:Pyridoxine; D013831:Thiamine
Dietary supplement; Enzymes; Immuno-modulatory; Vanillic acid; Vitamins chitosan