Hydatid detection using the near-infrared transmission angular spectra of porous silicon microcavity biosensors.
Hydatid, which is a parasitic disease, occurs today in many regions worldwide. Because it can present a serious threat to people's health, finding a fast, convenient, and economical means of detection is important. This paper proposes a label- and spectrophotometer-free apparatus that uses optical biological detection based on porous silicon microcavities. In this approach, the refractive index change induced by the biological reactions of a sample in a porous silicon microcavity is detected by measuring the change in the incidence angle corresponding to the maximum transmitted intensity of a near-infrared probe laser. This paper reports that the proposed method can achieve the label-free detection of 43 kDa molecular weight hydatid disease antigens with high sensitivity.
School of Physical Science and Technology, Xinjiang University, Urumqi 830046, China.
Peng
P
Li
College of Information Science and Engineering, Xinjiang University, Urumqi 830046, China.
Zhenhong
Z
Jia
The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Guodong
G
Lü
D015374:Biosensing Techniques / Q000295:instrumentation*; D004443:Echinococcosis / Q000175:diagnosis*; D008027:Light; D016062:Porosity; D012825:Silicon / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared
D012825:Silicon