Antibacterial Effect of Bacteriocin Isolated From Lactobacillus Plantarum ATCC 8014 on Postoperative Infection of Mandibular Fracture In Vivo.
OBJECTIVE
The primary objective of this study was to verify the effects of bacteriocin in treatment of postoperative infection of mandibular fracture in vivo.


METHODS
Eighty-two mice were inoculated intravenously with staphylococcal suspensions. Bacterial cultures were obtained from implants. Blood samples were collected at 1, 2, 4, 6, and 8 hours after the injection of bacteriocins.


RESULTS
Bacteriocins have significant inhibitory effects on Staphylococcus aureus (P < 0.05) and there are significant differences interleukin (IL)-8 and IL-10 in serum (P < 0.05).


CONCLUSIONS
Bacteriocin isolated from L plantarum may be one of promising ways to control postoperative infection of mandibular fracture in vivo.
Department of Oral and Maxillofacial Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Tao
T
Fu
Yan-Ming
YM
Liu
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001430:Bacteriocins / Q000494:pharmacology*; D016753:Interleukin-10 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D048191:Lactiplantibacillus plantarum / Q000502:physiology*; D008337:Mandibular Fractures / Q000601:surgery*; D008341:Mandibular Prosthesis / Q000009:adverse effects*; D019930:Mandibular Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D051379:Mice; D008953:Models, Anatomic; D016459:Prosthesis-Related Infections / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D016209:Interleukin-8; D016753:Interleukin-10