Stereoselective Palladium-Catalyzed Decarboxylative γ-Arylation of Acyclic β,γ-Unsaturated Carboxylic Acids.
Palladium-catalyzed γ-arylation of acyclic β,γ-unsaturated carboxylic acids with various aryl iodides is reported. The cascade comprises a decarboxylative γ-palladation of β,γ-unsaturated α,α'-disubstituted carboxylic acids and subsequent C(sp2)-C(sp3) bond formation to provide diaryl vinyl methanes in moderate to good yields and high E/Z-selectivities. Reaction with an enantiomerically pure acid revealed that the process occurs with high stereospecificity.
Organisch Chemisches Institut, Westfälische Wilhelms-Universität Münster , Corrensstraße 40, 48149 Münster, Germany.
Ina
I
Scheipers
Organisch Chemisches Institut, Westfälische Wilhelms-Universität Münster , Corrensstraße 40, 48149 Münster, Germany.
Eva
E
Koch
Organisch Chemisches Institut, Westfälische Wilhelms-Universität Münster , Corrensstraße 40, 48149 Münster, Germany.
Armido
0000-0002-1706-513X
A
Studer