The effects of intra-articular levobupivacain versus levobupivacain plus magnesium sulfate on postoperative analgesia in patients undergoing arthroscopic meniscectomy: A prospective randomized controlled study.
OBJECTIVE
The aim of this study was to compared the effectiveness of intraarticular levobupivacain with levobupivacain and magnesium sulfate.


METHODS
In this prospective randomized double blinded study, 96 patients (67 male, 29 female; age range: 18-65 years) with ASA (American Society of Anesthesiologist) score I and II, who had undergone arthroscopic meniscectomy operation, were divided to 3 groups that had postoperative analgesia with intra-articular saline injection (control group), levobupivacain injection (L group) or levobupivacain and magnesium sulfate injection (LM group). Patients were compared with postoperative VAS (Visual Analog Score) score during rest and activity, opioid analgesic need, non-opioid analgesic need and other medication needs.


RESULTS
Postoperative VAS scores during rest and activation at early postoperative period were significantly lower at LM group when compared with L group and lower than control group at all time periods. Opioid analgesic need, non-opioid analgesic need and other medication needs for non-pain symptoms were lower at LM group when compared with L and control groups at all time periods.


CONCLUSIONS
Intraarticular magnesium sulfate plus Levobupivacain injection is a safe and effective method for post operative pain management after arthroscopic meniscectomy.
Yeditepe University Faculty of Medicine, Turkey.
Nurcan
N
Kızılcık
Yeditepe University Faculty of Medicine, Turkey. Electronic address: turhanozler@hotmail.com.
Turhan
T
Özler
Yeditepe University Faculty of Medicine, Turkey.
Ferdi
F
Menda
Yeditepe University Faculty of Medicine, Turkey.
Çağatay
Ç
Uluçay
Yeditepe University Faculty of Medicine, Turkey.
Özge
Ö
Köner
Yeditepe University Faculty of Medicine, Turkey.
Faik
F
Altıntaş
D000293:Adolescent; D000328:Adult; D000368:Aged; D000698:Analgesia / Q000379:methods*; D000700:Analgesics / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001182:Arthroscopy; D002045:Bupivacaine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D000077554:Levobupivacaine; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D000074403:Meniscectomy / Q000379:methods*; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods*; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy*; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008278:Magnesium Sulfate; D000077554:Levobupivacaine; D002045:Bupivacaine
Arthroscopic menisectomy; Arthroscopic menisectomy LEVEL OF EVIDENCE: Level I Therapeutic study.; Chondrocyte apoptosis; Intra-articular injection; Levobupivacain; Magnesium sulfate; Pain management; Postoperative analgesia