Oxidative Stress Induced by Polymyxin E Is Involved in Rapid Killing ofPaenibacillus polymyxa.
Historically, the colistin has been thought to kill bacteria through membrane lysis. Here, we present an alternative mechanism that colistin induces rapidPaenibacillus polymyxadeath through reactive oxygen species production. This significantly augments our understanding of the mechanism of colistin action, which is critical knowledge toward the yield development of colistin in the future.
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Zhiliang
0000-0003-4849-7055
Z
Yu
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Yuyi
Y
Zhu
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Wangrong
W
Qin
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Jianhua
0000-0001-8294-3798
J
Yin
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Juanping
0000-0003-4446-0810
J
Qiu
D003091:Colistin / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D000070057:Paenibacillus polymyxa / Q000378:metabolism*
D003091:Colistin