The efficacy of proanthocyanidins and secnidazole in the treatment of chronic periodontitis after scaling and root planing therapy.
The aim of this study is to evaluate the clinical and microbiological effect of the systemic antibiotic therapy of proanthocyanidins and secnidazole on periodontitis. Seventy-five subjects with chronic periodontitis were randomly divided into two treatment groups (secnidazole or proanthocyanidins) and one placebo control group (25 cases each). Plaque index (PI), gingival index (GI), gingival bleeding index (BI), probing pocket depth (PPD), and clinical attachment level (CAL) were carried out at baseline, post-treatment and 3 months after treatment. Microbial analysis was performed at baseline and post-treatment. The results show that the two treatment groups had greater mean reduction in BI, GI, and PPD evaluated at both post-treatment and 3 months after treatment compared to the control group (p less than 0.05), but there were no significant differences in those of PI and CAL (except CAL evaluated at post-treatment, p 0.05). After treatment, culturable bacteria counts significantly decreased. In conclusion, the adjunctive use of proanthocyanidins or secnidazole in combination with scaling and root planing in adults with periodontitis is effective in reducing the pathogenic flora and achieves significantly better clinical results to a certain degree.
Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Ninth Peoples Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
M
M
Li
Department of Traditional Chinese Medicine Shanghai 8th hospital, Shanghai, China.
R
R
Li
Department of Traditional Chinese Medicine Shanghai 8th hospital, Shanghai, China.
Q
Q
Jin
Department of Traditional Chinese Medicine Shanghai 8th hospital, Shanghai, China.
J
J
Pang
Department of Traditional Chinese Medicine Shanghai 8th hospital, Shanghai, China.
Z
Z
Xu
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D058491:Bacterial Load; D055113:Chronic Periodontitis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D010512:Periodontal Index; D010519:Periodontium / Q000187:drug effects / Q000382:microbiology / Q000601:surgery; D044945:Proanthocyanidins / Q000627:therapeutic use*; D016745:Root Planing; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D044945:Proanthocyanidins; D008795:Metronidazole; C016724:secnidazole