The Association between Diffuse Myocardial Fibrosis on Cardiac Magnetic Resonance T1 Mapping and Myocardial Dysfunction in Diabetic Rabbits.
The objective of this study was to assess the relationship between imaging surrogates for diffuse fibrosis and myocardial dysfunction. Thirty-six New Zealand white rabbits were classified into two groups: a control group (n = 18) and an alloxan-induced diabetes mellitus (DM) group (n = 18). For all rabbits, conventional ultrasonography, two-dimensional speckle tracking, and cardiac magnetic resonance (CMR) T1 mapping were performed; all of the rabbits were then sacrificed for Masson's staining. The extracellular volume (ECV) was calculated from pre- and post-contrast T1 values and compared with myocardial function measured by echocardiography using Pearson's correlation. In the DM group, ECV increased as the duration of diabetes increased, consistent with the changes in myocardial fibrosis verified by pathology. Moreover, ECV was strongly correlated with the early diastolic strain rate (r = -0.782, p < 0.001) and moderately correlated with the radial systolic peak strain (r = 0.478, p = 0.045). Thus, ECV is an effective surrogate for myocardial diffuse fibrosis on CMR imaging, and higher ECV values are associated with an increased impairment of myocardial diastolic function.
Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Mu
M
Zeng
Department of Ultrasound, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Yingyan
Y
Qiao
Department of Radiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China.
Zhaoying
Z
Wen
Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Jun
J
Liu
Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Enhua
E
Xiao
Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Changlian
C
Tan
Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Yibin
Y
Xie
MR Collaborations NE Asia, Siemens Healthcare, Beijing, China.
Jing
J
An
Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Zishu
Z
Zhang
Department of Radiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China.
Zhanming
Z
Fan
Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Debiao
D
Li
D000818:Animals; D001706:Biopsy; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000209:etiology*; D048909:Diabetes Complications / Q000150:complications*; D004452:Echocardiography; D005355:Fibrosis; D008279:Magnetic Resonance Imaging; D008297:Male; D011817:Rabbits; D018754:Ventricular Dysfunction