Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy.
The thyroid hormone-inactivating enzyme type 3 deiodinase (D3) is induced during hypertrophic and ischemic cardiomyopathy, leading to a state of local cardiac hypothyroidism. Whether D3 induction occurs in dilated cardiomyopathy is unknown.



This study characterized changes in cardiac D3 and thyroid hormone signaling in a transgenic model of progressive dilated cardiomyopathy (TG9 mice).



Cardiac D3 was dramatically induced 15-fold during the progression of dilated cardiomyopathy in TG9 mice. This D3 induction localized to cardiomyocytes and was associated with a decrease in myocardial thyroid hormone signaling.



Cardiac D3 is induced in a mouse model of dilated cardiomyopathy, indicating that D3 induction may be a general response to diverse forms of cardiomyopathy.
1 Thyroid Program, Division of Endocrinology, Boston Children's Hospital , Boston, Massachusetts.
Ari J
AJ
Wassner
1 Thyroid Program, Division of Endocrinology, Boston Children's Hospital , Boston, Massachusetts.
Rebecca H
RH
Jugo
2 Department of Pathology, Brigham and Women's Hospital , Boston, Massachusetts.
David M
DM
Dorfman
2 Department of Pathology, Brigham and Women's Hospital , Boston, Massachusetts.
Robert F
RF
Padera
1 Thyroid Program, Division of Endocrinology, Boston Children's Hospital , Boston, Massachusetts.
Michelle A
MA
Maynard
3 Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital , Boston, Massachusetts.
Ann M
AM
Zavacki
4 Departments of Pediatrics and Genetics, Washington University School of Medicine , St. Louis, Missouri.
Patrick Y
PY
Jay
1 Thyroid Program, Division of Endocrinology, Boston Children's Hospital , Boston, Massachusetts.
Stephen A
SA
Huang
D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D018450:Disease Progression; D007453:Iodide Peroxidase / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; C117274:iodothyronine deiodinase type III; D007453:Iodide Peroxidase; D013974:Thyroxine
D3; cardiomyopathy; deiodinase; heart; heart failure