Anticoccidial effects of Aloe secundiflora leaf extract against Eimeria tenella in broiler chicken.
Anticoccidial effects of Aloe secundiflora crude leaf extract was tested in broiler chickens following oral infection with Eimeria tenella. Sixty 22-day-old birds were divided into six groups of ten birds each. Three treatment groups A, B, and C were fed with the extract (100, 250, and 500 mg/day, respectively) mixed in feed for 10 days, and three control groups: group D (drug control) administered 300 mg/l of sulfachloropyrazine sodium soluble powder in drinking water for 5 days, group E (infected/non-medicated positive control), and group F (uninfected/non-medicated negative control). Except for group F, all groups were orally inoculated with 75,000 sporulated oocysts of E. tenella. The effects of the extract on E. tenella infection were evaluated by severity of bloody diarrhea, body weight (BW) gain, oocyst output, and lesion score. No bird in the treated groups died of coccidiosis, and severity of bloody diarrhea was milder than in the positive control group. BW gains in the treated groups were significantly higher than in group E (p < 0.05). The lesion scores of the treated groups were significantly lower than that of group E. Oocyst output in groups A, B, and C were 11.23, 8.24, and 6.82 × 106, respectively. As compared with the negative control group (12.84 × 106), the reductions in oocyst production were 12.54, 35.83, and 46.88%, respectively. Oocyst output significantly reduced with an increase in Aloe dosage. The findings of this study suggest that Aloe secundiflora extract presents an alternative anticoccidial agent for the control of avian coccidiosis.
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Ministry of Education Key Lab for Avian Preventive Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, People's Republic of China.|School of Agriculture and Biotechnology, Karatina University, Nyeri, Kenya.|Zoology Department, Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.
Fredrick
F
Kaingu
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Ministry of Education Key Lab for Avian Preventive Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, People's Republic of China.
Dandan
D
Liu
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Ministry of Education Key Lab for Avian Preventive Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, People's Republic of China.
Lele
L
Wang
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Ministry of Education Key Lab for Avian Preventive Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, People's Republic of China. yzjptao@126.com.
Jianping
J
Tao
Zoology Department, Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.
Rebecca
R
Waihenya
Zoology Department, Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.
Helen
H
Kutima
D000504:Aloe / Q000737:chemistry; D000818:Animals; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy / Q000401:mortality / Q000662:veterinary*; D003049:Coccidiostats / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D016786:Eimeria tenella; D033661:Oocysts / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D011201:Poultry Diseases / Q000188:drug therapy* / Q000401:mortality; D015430:Weight Gain / Q000187:drug effects
D003049:Coccidiostats; D010936:Plant Extracts
Aloe secundiflora; Anticoccidial; Chickens; Eimeria tenella