Signet-ring Cells in the Skin: A Case of Late-onset Cutaneous Metastasis of Gastric Carcinoma and a Brief Review of Histological Approach.
Up to 10% of patients with visceral malignancies develop skin metastases during their clinical course and these metastases constitute about 2% of all skin cancers. Skin metastasis may be the first sign of a clinically silent visceral cancer or represent recurrence of an internal malignancy. In both situations, they are associated with poor prognosis, which can partly be attributed to underdiagnosis. In this paper, a case of relapsing gastric adenocarcinoma, which manifested itself as asymptomatic cutaneous papules and nodules on a patient's head and neck, is reported and histopathological approach to the cutaneous lesions containing signet-ring cell is briefly reviewed.
Department of Dermatology and Venerology, Kirikkale University , Turkey.
Özgür
Ö
Gündüz
Department of Dermatology, Özel Keçiören Hospital , Turkey.
Mehmet Can
MC
Emeksiz
Department of Pathology Kirikkale University , Turkey.
Pinar
P
Atasoy
Department of Dermatology and Venerology, Dumlupinar University, Evliya Çelebi Teaching Hospital , Turkey.
Mehtap
M
Kidir
Department of Oncology, Kirikkale University , Turkey.
Selim
S
Yalçin
Department of Dermatology and Venerology, Kirikkale University , Turkey.
Serkan
S
Demirkan
Signet-ring cell; immunohistochemistry; metastatic skin cancer