[Hemorrhage treatment: Evaluation of the proper use of fibrinogen concentrate].
An increase in fibrinogen concentrate prescriptions was noticed in 2015 after several guidelines regarding their use were published. We tried to evaluate if they were used appropriately. To evaluate the conformity of the prescriptions to these guidelines, we searched for each prescription if a dosage of blood fibrinogen was made, if its result was below the limit recommended to prescribe fibrinogen concentrate, and if the posology was in line with the recommendations. Effect and security of the treatment was also evaluated. We analyzed 202 prescriptions for 117 patients. The indications are respected except for one prescription for which we could not find it. The blood fibrinogen is measured for 76% of the prescriptions, 59% of the results are below the limit recommended to prescribe. The posology is conforming to the guidelines for 73% of the prescriptions, it is below the dose recommended for 20%. Patients who were prescribed low doses seemed less at risk than the others which questions the necessity of the prescriptions. The guidelines respect depends on the emergency of the prescription situation. It would be interesting to conduct a prospective study to better explain why doses below those recommended are prescribed.
Service pharmacie, hôpital François-Mitterrand, 14, rue Gaffarel, 21000 Dijon, France. Electronic address: jennifer.howlett@chu-dijon.fr.
Jennifer
J
Howlett
Service pharmacie, hôpital François-Mitterrand, 14, rue Gaffarel, 21000 Dijon, France.
Christelle
C
Prudent
Service hémostase, plateau technique de biologie, hôpital François-Mitterrand, 21000 Dijon, France.
Emmanuel
E
De Maistre
Service pharmacie, hôpital François-Mitterrand, 14, rue Gaffarel, 21000 Dijon, France.
Philippe
P
Fagnoni
Service pharmacie, hôpital François-Mitterrand, 14, rue Gaffarel, 21000 Dijon, France.
Aline
A
Lazzarotti
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D005260:Female; D005340:Fibrinogen / Q000627:therapeutic use*; D005602:France; D019983:Guideline Adherence; D006470:Hemorrhage / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D055815:Young Adult
D005340:Fibrinogen
Fibrinogen; Fibrinogène; Hemorrhage; Hémorragie; Prescription