Treatment Failure of Dihydroartemisinin/Piperaquine for Plasmodium falciparum Malaria, Vietnam.
We conducted a study in Binh Phuoc, Vietnam, in 2015 on the therapeutic efficacy of dihydroartemisinin/piperaquine for Plasmodium falciparum malaria. A high number of treatment failures (14/40) was found, and piperaquine resistance in Vietnam was confirmed. A change in the malaria treatment policy for Vietnam is in process.
Bui Quang
BQ
Phuc
Charlotte
C
Rasmussen
Tran Thanh
TT
Duong
Le Than
LT
Dong
Mai Anh
MA
Loi
Didier
D
Ménard
Joel
J
Tarning
Dorina
D
Bustos
Pascal
P
Ringwald
Gawrie Loku
GL
Galappaththy
Nguyen Quang
NQ
Thieu
D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use*; D037621:Artemisinins / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010963:Plasmodium falciparum / Q000235:genetics; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D011804:Quinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D014744:Vietnam / Q000453:epidemiology; D010879:Piperazines
D000962:Antimalarials; D037621:Artemisinins; D004338:Drug Combinations; D015800:Protozoan Proteins; D011804:Quinolines; C039060:artenimol; C034759:piperaquine; D010879:Piperazines
Plasmodium falciparum; Vietnam; antimicrobial resistance; artemisinin; dihydroartemisinin/piperaquine; drug resistance; malaria; mefloquine; piperaquine; vector-borne infections