Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?
We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.
Department of Pediatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
Noortje B
NB
Eijsvoogel
Department of Pediatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
Mirjam I
MI
Hollegien
Department of Pediatrics, Màxima Medical Centre, Veldhoven, The Netherlands.
Vinus L A
VLA
Bok
Department of Pediatrics, Juliana Children's Hospital/Haga Hospital, The Hague, The Netherlands.
Arda G
AG
Derksen Lubsen
Department of Pediatrics, Gelre Hospital, Zutphen, The Netherlands.
Felix P J
FPJ
Dikken
Department of Medical Microbiology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
Sander A C A P
SACAP
Leenders
Department of Pediatrics, Slingeland Hospital, Doetinchem, The Netherlands.
Arjan
A
Pijning
Department of Pediatrics, St. Antonius Hospital, Nieuwegein, The Netherlands.
Erica
E
Post
Department of Pediatrics, University of Antwerp, Antwerp University Hospital, Antwerp, Belgium.
Marek
M
Wojciechowski
Jeroen Bosch Academy, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
Mirrian
M
Hilbink
Department of Pediatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.|Department Tranzo, Tilburg University, Tilburg, The Netherlands.
Esther
0000-0003-4311-3550
E
de Vries
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008297:Male; D011795:Surveys and Questionnaires
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines
Down syndrome; hepatitis B vaccination; hepatitis B virus