Formulation and Drug Loading Features of Nano-Erythrocytes.
Nano erythrocyte ghosts have recently been used as drug carriers of water-soluble APIs due to inherit biological characteristics of good compatibility, low toxicity, and small side-effect. In this study, we developed a novel drug delivery system based on nano erythrocyte ghosts (STS-Nano-RBCs) to transport Sodium Tanshinone IIA sulfonate (STS) for intravenous use in rat. STS-Nano-RBCs were prepared by hypotonic lysis and by extrusion methods, and its biological properties were investigated compared with STS injection. The results revealed that STS-Nano-RBCs have narrow particle size distribution, good drug loading efficiency, and good stability within 21 days. Compared with STS injection, STS-Nano-RBCs extended the drug release time in vitro and in vivo with better repairing effect on oxidative stress-impaired endothelial cells. These results suggest that the nano erythrocyte ghosts system could be used to deliver STS.
Department of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, No. 280 Waihuandong Road, Guangzhou, 510006, China.
Xiaoting
X
Dong
Department of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, No. 280 Waihuandong Road, Guangzhou, 510006, China.
Yawei
Y
Niu
Guangzhou Institute for Drug Control, 23 Xizeng Road, Guangzhou, 510160, China.
Yi
Y
Ding
Department of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, No. 280 Waihuandong Road, Guangzhou, 510006, China.
Yuemin
Y
Wang
Department of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, No. 280 Waihuandong Road, Guangzhou, 510006, China.
Jialan
J
Zhao
Jacobson Pharma Group, 7 Dai Shun Street, Tai Po District, NT, Hong Kong.
Wei
W
Leng
Department of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, No. 280 Waihuandong Road, Guangzhou, 510006, China. dor_qin@163.com.
Linghao
L
Qin
Drug delivery; Erythrocyte ghosts; Repairing effect; STS