A Rare Tumor that Mimicked Metastasis in a Patient with Breast Cancer: Epithelioid Hemangioendothelioma.
A woman aged 50 years was diagnosed as having an invasive ductal carcinoma in the right breast and ductal carcinoma in situ in the left breast and underwent bilateral mastectomy eight years ago. A mass was identified during follow-up in positron-emission tomography (PET) image in the left infraclavicular region, indicating metastasis. Histopathologic examination showed a mass of 1.9 × 1 × 0.7 cm in dimensions characterized by spindle or round nuclei cells that formed island or cords in hyaline and myxoid ground and intracytoplasmic vacuoles containing erythrocytes. In the immunohistochemical analysis, tumor cells were widespread with diffuse positivity with CD34 and vimentin. These findings redirected us from a diagnosis of metastatic carcinoma to epithelioid hemangioendothelioma, a rare tumor of intermediate vascular tumor groups. In this respect, confirmation through biopsy from considered cases of metastasis is important in making a definite pathologic differential diagnosis.
Department of Pathology, İstanbul Bilim University School of Medicine, İstanbul, Turkey.
Fatmagül Kuşku
FK
Çabuk
Clinic of Pathology, Gayrettepe Florence Nightingale Hospital, İstanbul, Turkey.
Fatma
F
Aktepe
Breasth Health Center, İstanbul Florence Nightingale Hospital, İstanbul, Turkey.
Ahmet Serkan
AS
İlgün
Breasth Health Center, İstanbul Florence Nightingale Hospital, İstanbul, Turkey.
Dauren
D
Sarsenov
Clinic of Radiology, Gayrettepe Florence Nightingale Hospital, İstanbul, Turkey.
Filiz
F
Elbüken
Department of General Surgery, İstanbul University İstanbul School of Medicine, İstanbul, Turkey.
Vahit
V
Özmen
Hemangioendothelioma; breast; breast carcinoma; invasive ductal carcinoma; lymph nodes; metastasis