Transition Metal, Azide, and Oxidant-Free Homo- and Heterocoupling of Ambiphilic Tosylhydrazones to the Regioselective Triazoles and Pyrazoles.
With N-tosylhydrazone as an ambiphilic reagent, an unprecedented cyclization reaction of two identical or different tosylhydrazones has been developed to access various 4,5-disubstituted-2H-triazoles under transition metal, azide, and oxidant-free conditions. A mechanistic rationalization study led to the identification of several electronically diverse unsaturated systems for regioselective synthesis of 1- and 2-substituted 1,2,3-triazoles and pyrazoles.
Department of Chemistry, Indian Institute of Technology Guwahati , Assam 781039, India.
Subhankar
S
Panda
Organic Chemistry Division, CSIR-National Chemical Laboratory , Maharashtra-411008, India.
Pradip
P
Maity
Department of Chemistry, Indian Institute of Technology Guwahati , Assam 781039, India.
Debasis
0000-0002-6920-9000
D
Manna