Synthesis, characterization and biological evaluation of novel 2,5 substituted-1,3,4 oxadiazole derivatives.
In the present study, a series of 3-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-N-substituted aniline have been synthesized by multistep reaction scheme. Benzohydrazide was used as the starting material. The structures of all synthesized compounds are characterized and confirmed by FT-IR,1H and C13NMR and mass spectral studies with the intention of developing the novel biologically active compounds. All title synthetic compounds were screened for their antidiabetic, anti-inflammatory and anticancer activities.
Department of Chemistry, Government College of Engineering, Salem 11, Tamil Nadu, India.
Selvaraj
S
Kavitha
Department of Chemistry, Government College of Engineering, Salem 11, Tamil Nadu, India.
Kulanthai
K
Kannan
Department of Chemistry, Government College of Engineering, Salem 11, Tamil Nadu, India.
Sadhasivam
S
Gnanavel
1,3,4-Oxadiazole; Anticancer; Antidiabetic; Antiinflammatory; MTT assay