Potential mechanisms underlying CDK5 related Osteosarcoma progression.
Identification of new prognostic biomarkers and therapeutic targets is of crucial importance for patients with osteosarcoma. Cyclin-dependent kinase 5 (CDK5) is overexpressed in several tumor types. However, the exact role CDK5 plays in osteosarcoma is still unknown.



In this study, we explored the association between CDK5 expression and the prognosis of osteosarcoma patients using publicly available gene expression datasets. Potential molecular mechanisms underlying its pro-malignant role in cancer progression were also discussed.



We demonstrated that tricarboxylic acid (TCA) cycle is activated while antigen presentation is repressed in patients with CDK5 overexpression and poor survival. This results indicated that sufficient energy production and tumor immune escape are important characteristics and potential therapeutic targets for this subgroup of osteosarcoma patients. Furthermore, several critical hub genes that are associated with CDK5 related osteosarcoma progression such as MELK were identified.



This study discussed the pro-malignant role of CDK5 and potential mechanisms involved. Further preclinical and clinical studies to develop CDK5 based treatments are warranted.
a Department of Orthopedics , the First Clinical Medical College of Zhejiang Chinese Medical University , Hangzhou , PR China.|b Zhejiang Provincial Hospital of Traditional Chinese Medicine , Hangzhou , PR China.
Hang-Xing
HX
Bao
c Department of Orthopedics , Zhejiang Provincial People's Hospital , Hangzhou , PR China.|f People's Hospital of Hangzhou Medical College , Hangzhou , PR China.
Qing
Q
Bi
d Department of Pathology , Zhejiang Provincial People's Hospital , Hangzhou , PR China.|f People's Hospital of Hangzhou Medical College , Hangzhou , PR China.
Yong
Y
Han
c Department of Orthopedics , Zhejiang Provincial People's Hospital , Hangzhou , PR China.|f People's Hospital of Hangzhou Medical College , Hangzhou , PR China.
Chen
C
Zhao
e Department of Cardiology , Zhejiang Provincial People's Hospital , Hangzhou , PR China.|f People's Hospital of Hangzhou Medical College , Hangzhou , PR China.
Hai
H
Zou
D001859:Bone Neoplasms / Q000235:genetics / Q000473:pathology*; D002952:Citric Acid Cycle / Q000235:genetics; D051360:Cyclin-Dependent Kinase 5 / Q000235:genetics*; D030541:Databases, Genetic; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D012516:Osteosarcoma / Q000235:genetics / Q000473:pathology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D013534:Survival
C484610:MELK protein, human; D051360:Cyclin-Dependent Kinase 5; D017346:Protein Serine-Threonine Kinases; C495905:CDK5 protein, human
Osteosarcoma; cyclin-dependent kinase 5; therapeutic targets; tumor immune escape