Utility values associated with advanced or metastatic non-small cell lung cancer: data needs for economic modeling.
Cost-effectiveness analyses often inform healthcare reimbursement decisions. The preferred measure of effectiveness is the quality adjusted life year (QALY) gained, where the quality of life adjustment is measured in terms of utility. Areas covered: We assessed the availability and variation of utility values for health states associated with advanced or metastatic non-small cell lung cancer (NSCLC) to identify values appropriate for cost-effectiveness models assessing alternative treatments. Our systematic search of six electronic databases (January 2000 to August 2015) found the current literature to be sparse in terms of utility values associated with NSCLC, identifying 27 studies. Utility values were most frequently reported over time and by treatment type, and less frequently by disease response, stage of disease, adverse events or disease comorbidities. Expert commentary: In response to rising healthcare costs, payers increasingly consider the cost-effectiveness of novel treatments in reimbursement decisions, especially in oncology. As the number of therapies available to treat NSCLC increases, cost-effectiveness analyses will play a key role in reimbursement decisions in this area. Quantifying the relationship between health and quality of life for NSCLC patients via utility values is an important component of assessing the cost effectiveness of novel treatments.
a Global Patient Outcomes and Real World Evidence , Eli Lilly and Company , Windlesham , UK.
Jacqueline
J
Brown
b Analysis Group, Inc , Menlo Park , CA , USA.
Keziah
K
Cook
b Analysis Group, Inc , Menlo Park , CA , USA.
Kelly
K
Adamski
b Analysis Group, Inc , Menlo Park , CA , USA.
Jocelyn
J
Lau
c UK Health Outcomes and HTA team , Eli Lilly and Company Limited , Basingstoke , Hampshire , UK.
Danielle
D
Bargo
c UK Health Outcomes and HTA team , Eli Lilly and Company Limited , Basingstoke , Hampshire , UK.
Sarah
S
Breen
b Analysis Group, Inc , Menlo Park , CA , USA.
Anita
A
Chawla
D002289:Carcinoma, Non-Small-Cell Lung / Q000191:economics / Q000473:pathology / Q000628:therapy*; D003362:Cost-Benefit Analysis; D017048:Health Care Costs; D006801:Humans; D008175:Lung Neoplasms / Q000191:economics / Q000473:pathology / Q000628:therapy*; D018803:Models, Economic; D009367:Neoplasm Staging; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D012051:Reimbursement Mechanisms
Cost-effectiveness analysis; Health state; Health-related quality of life; NSCLC; Non-small cell lung cancer; Utility