Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients.
OBJECTIVE
To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations.


METHODS
Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without. For both groups the SNP G1612A (rs10434) of the VEGF gene was genotyped by real time polymerase chain reaction (RT-PCR).


RESULTS
Statistically significant difference was found in genotype and allele frequencies between both groups (AA [70% vs 13.3%, p<0.001] and GG [10% vs 66.7%, p<0.001]).


CONCLUSIONS
Polymorphism in the gene coding for VEGF may be associated with increased incidence of neuropsychiatric lupus in SLE patients.
Cairo University, Faculty of Medicine, Chemical Pathology Department, Cairo, Egypt.
Sherif
S
Taha
Cairo University, Faculty of Medicine, Rheumatology Department, Cairo, Egypt. Electronic address: sherif775@hotmail.com.
Sherif Mohammed
SM
Gamal
Beni-Sweif University, Faculty of Medicine, Internal Medicine Department, Beni-Sweif, Egypt.
Mohamed
M
Nabil
Cairo University, Faculty of Medicine, Rheumatology Department, Cairo, Egypt.
Nahla
N
Naeem
Cairo University, Faculty of Medicine, Neurology Department, Cairo, Egypt.
Dalia
D
Labib
National Research Center, Internal Medicine Department, Cairo, Egypt.
Ibrahim
I
Siam
Cairo University, Faculty of Medicine, Rheumatology Department, Cairo, Egypt.
Tamer Atef
TA
Gheita
D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020945:Lupus Vasculitis, Central Nervous System / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
D042461:Vascular Endothelial Growth Factor A
G1612A (rs10434) gene; Gene G1612A (rs10434); LES; Manifestações neuropsiquiátricas; Neuropsychiatric manifestations; Polimorfismo; Polymorphism; SLE; VEGF