High-resolution anatomic correlation of cyclic motor patterns in the human colon: Evidence of a rectosigmoid brake.
Colonic cyclic motor patterns (CMPs) have been hypothesized to act as a brake to limit rectal filling. However, the spatiotemporal profile of CMPs, including anatomic origins and distributions, remains unclear. This study characterized colonic CMPs using high-resolution (HR) manometry (72 sensors, 1-cm resolution) and their relationship with proximal antegrade propagating events. Nine healthy volunteers were recruited. Recordings were performed over 4 h, with a 700-kcal meal given after 2 h. Propagating events were visually identified and analyzed by pattern, origin, amplitude, extent of propagation, velocity, and duration. Manometric data were normalized using anatomic landmarks identified on abdominal radiographs. These were mapped over a three-dimensional anatomic model. CMPs comprised a majority of detected propagating events. Most occurred postprandially and were retrograde propagating events (84.9 ± 26.0 retrograde vs. 14.3 ± 11.8 antegrade events/2 h,P= 0.004). The dominant sites of initiation for retrograde CMPs were in the rectosigmoid region, with patterns proximally propagating by a mean distance of 12.4 ± 0.3 cm. There were significant differences in the characteristics of CMPs depending on the direction of travel and site of initiation. Association analysis showed that proximal antegrade propagating events occurred independently of CMPs. This study accurately characterized CMPs with anatomic correlation. CMPs were unlikely to be triggered by proximal antegrade propagating events in our study context. However, the distal origin and prominence of retrograde CMPs could still act as a mechanism to limit rectal filling and support the theory of a "rectosigmoid brake."NEW & NOTEWORTHYRetrograde cyclic motor patterns (CMPs) are the dominant motor patterns in a healthy prepared human colon. The major sites of initiation are in the rectosigmoid region, with retrograde propagation, supporting the idea of a "rectosigmoid brake." A significant increase in the number of CMPs is seen after a meal. In our study context, the majority of CMPs occurred independent of proximal propagating events, suggesting that CMPs are primarily controlled by external innervation.
Department of Surgery, University of Auckland, Auckland, New Zealand.
Anthony Y
AY
Lin
Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Peng
P
Du
Gastroenterology and Surgery, Flinders Medical Centre, Adelaide, South Australia, Australia; and.
Philip G
PG
Dinning
Computer Science, Engineering and Mathematics, Flinders University, Bedford Park, South Australia, Australia.
John W
JW
Arkwright
Department of Surgery, University of Auckland, Auckland, New Zealand.
Jozef P
JP
Kamp
Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Leo K
LK
Cheng
Department of Surgery, University of Auckland, Auckland, New Zealand.|Surgery, Auckland City Hospital, Auckland, New Zealand.
Ian P
IP
Bissett
Department of Surgery, University of Auckland, Auckland, New Zealand; greg.ogrady@auckland.ac.nz.|Surgery, Auckland City Hospital, Auckland, New Zealand.
Gregory
G
O'Grady
D000328:Adult; D000368:Aged; D001683:Biological Clocks / Q000502:physiology*; D003106:Colon / Q000033:anatomy & histology* / Q000502:physiology*; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008365:Manometry / Q000379:methods; D008875:Middle Aged; D012007:Rectum / Q000033:anatomy & histology* / Q000502:physiology*
colonic motility; high-resolution manometry; rectosigmoid brake