Brief Report: IL-1β Levels Are Associated With Chronic Multisite Pain in People Living With HIV.
The pathophysiology of chronic pain experienced by people living with HIV (PLWH) in the current antiretroviral treatment era is poorly understood. We sought to investigate the relationship between inflammation and chronic pain in PLWH. We hypothesized that, among PLWH who have undetectable HIV viral loads, those with chronic multisite pain (CMP) would have higher levels of circulating pain-related inflammatory markers than those without chronic pain.



This study was conducted at the University of Alabama at Birmingham's Center for AIDS Research Network of Integrated Clinical System site.



We compared inflammatory markers in 70 PLWH with CMP and 70 PLWH without chronic pain. Custom multiplex human inflammatory assays were completed on banked plasma specimens to measure cytokines commonly associated with chronic inflammatory pain: interleukin 1β (IL-1β), eotaxin, IL-15, IL-6, tumor necrosis factor α, and leptin. Logistic regression models were built using group status (CMP vs no pain) as the outcome variable, with each cytokine as independent variables and age, sex, substance use, and prescribed opioid medications as covariates.



Participants were mostly men (71%); 53% were 50 years or older. The most common sites of pain were low back (86%), hands/feet (81%), and knee (66%). Median CD4 T-cell count was 676 cells per milliliter. IL-1β was significantly higher in the CMP group than in the individuals without chronic pain (odds ratio: 1.35, 95% confidence interval: 1.01 to 1.82, P < 0.05). Eotaxin, IL-15, IL-6, tumor necrosis factor α, and leptin were not significantly different between groups.



We found that PLWH who also have CMP have significantly higher levels of IL-1β than PLWH who do not have any pain. Future work on the role of IL-1β on chronic pain pathogenesis in this population may inform novel approaches to chronic pain management.
*Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL; †Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham, Birmingham, AL; ‡Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL; §Department of Psychology, University of Alabama at Birmingham, Birmingham, AL; ‖Division of Pain Medicine, University of Alabama at Birmingham, Birmingham, AL; and ¶Department of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, IN.
Jessica S
JS
Merlin
Andrew O
AO
Westfall
Sonya L
SL
Heath
Burel R
BR
Goodin
Jesse C
JC
Stewart
Robert E
RE
Sorge
Jarred
J
Younger
D000407:Alabama; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D059350:Chronic Pain / Q000150:complications* / Q000276:immunology* / Q000503:physiopathology / Q000523:psychology; D003863:Depression; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology / Q000821:virology; D053583:Interleukin-1beta / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha