Secretor and Salivary ABO Blood Group Antigen Status Predict Rotavirus Vaccine Take in Infants.
Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Abdul Momin
AM
Kazi
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Margaret M
MM
Cortese
Perinatal Institute, Cincinnati Childrens' Hospital Medical Center, Ohio.
Ying
Y
Yu
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Benjamin
B
Lopman
Perinatal Institute, Cincinnati Childrens' Hospital Medical Center, Ohio.
Ardythe L
AL
Morrow
Vaccine Access and Delivery, PATH, Seattle, Washington.
Jessica A
JA
Fleming
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Ohio.
Monica M
MM
McNeal
Vaccine Access and Delivery, PATH, Seattle, Washington.
A Duncan
AD
Steele
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Umesh D
UD
Parashar
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Anita K M
AKM
Zaidi
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Asad
A
Ali
D000017:ABO Blood-Group System / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000097:blood; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D007223:Infant; D010154:Pakistan; D010641:Phenotype; D012401:Rotavirus; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use; D012463:Saliva / Q000276:immunology / Q000821:virology
D000017:ABO Blood-Group System; D000914:Antibodies, Viral; D000956:Antigens, Viral; D007070:Immunoglobulin A; D022243:Rotavirus Vaccines
FUT2; Lewis antigen.; Secretor; blood group; infants; rotavirus; vaccine