Effect on the lipid parameters of an intervention to reduce weight in overweight and obese patients.
OBJECTIVE
To assess the effect on lipid parameters most associated with excess weight (triglycerides [TG], cholesterol, and high density lipoprotein [HDL-C]) of an intervention to reduce weight in overweight and obese patients.


METHODS
A randomised, controlled, double blind clinical trial, with three groups, and a follow-up of 12 months. Patients included in the study were randomised into three intervention groups: Obesity motivational intervention group with previously trained nurse (G1), lower intensity consultation, non-motivational group, with digital platform support (G2), and a third group that received a recommendation to lose weight and usual follow-up (G3). The anthropometric variables measured were height, weight, and abdominal/waist circumference, and laboratory results, total cholesterol, TG and HDL cholesterol).


RESULTS
The study include 176 patients, of whom 60 were randomised to G1, 61 to G2, and 59 to G3. All groups significantly decreased body weight at the end of the study, with a decrease in G1 (-5.6kg), followed by G2 (-4.3kg), and G3 (-1.7kg), with an overall mean loss of -3.9kg. There was a also significant decrease (P<.05) in total cholesterol and TG, and an increased HDL-C. These changes were more marked in the G1 group (the group that lost more weight). The clinical relevance indicators that were significant were: in the case of TG: G1/G3: relative risk: 1.42 (95% CI: 1.11-1.80); relative risk reduction: 41.7% (11.4-80.2); absolute risk reduction: 25% (9.2-40.8) and NNT: 5 (3-11). In the case of G1/G2 HDL-C: relative risk: 1.32 (1.07-1.63); relative risk reduction: 32.2% (7.4-62.6); absolute risk reduction: 21.1% (6.4-35.8) and NNT: 5 (3-16).


CONCLUSIONS
Weight reduction is accompanied by favorable changes in the lipid parameters related to overweight and obesity, being more intense the greater the weight loss.
Residencia geriátrica Los Álamos, Albacete, España.
M Loreto
ML
Tárraga Marcos
Medicina Interna, Fundación Fomento de la Salud (Fufosa), Barcelona, España.
Josefa María
JM
Panisello Royo
Unidad Lipidos, Clinica Quirón Salud, Albacete, España.
Julio A
JA
Carbayo Herencia
Nutricionista, Fundación Fomento de la Salud (Fufosa), Barcelona, España.
Nuria
N
Rosich Domenech
ABS ABRERA, Barcelona, España.
Josep
J
Alins Presas
Facultad de Medicina de Albacete, Universidad Castilla la Mancha, Albacete, España. Electronic address: pjtarraga@sescam.jccm.es.
Pedro J
PJ
Tárraga López
D000328:Adult; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000628:therapy*; D050177:Overweight / Q000097:blood / Q000628:therapy*; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference / Q000502:physiology; D015431:Weight Loss / Q000502:physiology*
D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol
Atencion primaria; Cholesterol; Colesterol; Intervención motivacional; Motivational intervention; Obesidad; Obesity; Primary care; Telemedicina; Telemedicine; Trigliceridos; Triglycerides