Magnesium Sulfate Mediates Morphine Administration Reduction in Varicocelectomy Surgery.
OBJECTIVE
Varicocelectomy is the most common operation carried out by doctors for male infertility treatment. The aim of varicocele treatment is to hinder the refluxing venous drainage to the testis, retaining arterial inflow, and lymphatic drainage. A lot of pain is generated after this surgery, and the use of opium should be reduced to nearest minimum, as all drugs are toxins. Thus the aim of the present study is to facilitate morphine usage reduction after varicocelectomy surgery.


METHODS
One-hundred (100) patients who were varicocelectomy candidate were randomized into two groups: experimental group contain 50 patients and control group contain 50 patients as well. In experimental group, 2 mL magnesium sulfate in 2 mL normal saline was injected into patient immediately after surgery. The control group received only 4 mL normal saline. Morphine dosage administered, and severity of pain monitoring was accessed and recorded with a visual analogue scale (VAS).


RESULTS
Result indicated that administration of morphine dosage in the test group 0.21 ± 0.64 mg was significantly lower as compared to the control group 0.75 ± 1.30 mg during the first 24-hour after surgery (p = 0.01). Average VAS scores in the experimental and control groups in the first 4-hour interval were 0.91 ± 1.30 and 2.9 ± 2.50 (p = 0.02) respectively. We observed a significant difference in the VAS score for pain severity and the dosages of morphine administered.


CONCLUSIONS
The experimental group with magnesium sulfate in its drug formulation showed better pain control compared to the control group which received only normal saline, whose pain manifested after every few hours. This can be used for the formulation of opium for this surgery in a large scale.
a Department of Anesthesiology , Lorestan University of Medical Sciences , Khorramabad , Iran.
Sedigheh
S
Nadri
b Department of Surgery , Lorestan University of Medical Sciences , Khorramabad , Iran.
Hormoz
H
Mahmoudvand
a Department of Anesthesiology , Lorestan University of Medical Sciences , Khorramabad , Iran.
Mahmoud Reza
MR
Moradkhani
D000293:Adolescent; D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008297:Male; D009020:Morphine / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D013521:Urologic Surgical Procedures, Male / Q000009:adverse effects* / Q000379:methods; D014646:Varicocele / Q000601:surgery*; D055815:Young Adult
D000701:Analgesics, Opioid; D008278:Magnesium Sulfate; D009020:Morphine
VAS score; Varicocelectomy; magnesium sulfate; morphine; opium; pain