A Preliminary Study about the Potential Effects of Heavy Metals on the Human Male Reproductive Parameters in HIV-Infected Population in China.
Due to the inconsistent effects of human immunodeficiency virus (HIV) on the human male reproduction in previous studies and the impacts of environmental exposures, such as heavy metals, on male reproduction receiving little attention in HIV-infected population, the aim of present study was to investigate whether heavy metals have potential effects on reproductive parameters in HIV-infected men. The current study assessed the associations between semen quality or serum hormone and concentration of the three heavy metal toxicants (lead (Pb), cadmium (Cd), and zinc (Zn)) in seminal, urine, and serum, and 50 HIV-infected men were recruited in the present study. Concentrations of Pb, Cd, and Zn were measured in three fluids by graphite furnace atomic absorption spectrophotometer. Semen analyses were performed according to World Health Organization criteria. Serum samples were analyzed for follicle-stimulating hormone, luteinizing hormone, and testosterone. HIV RNA viral load was determined by HIV virus loads kit. Spearman's rank correlations were used for correlation analyses. The results showed that the concentrations of Pb, Cd, and Zn were significantly correlated with semen quality and serum hormone. HIV-1 virus loads were significantly associated with increased seminal Pb. However, HIV-1 virus loads were not statistically associated with semen quality and serum hormone. Our findings suggested that environmental heavy metals had potential effects on reproductive parameters in HIV-infected men in China.
Chongqing institute of Population and Family Planning, Key Laboratory of Birth Defects and Reproductive Health, Chongqing, 400020, China.
Renyan
R
Li
Chongqing institute of Population and Family Planning, Key Laboratory of Birth Defects and Reproductive Health, Chongqing, 400020, China.
Letian
L
Zhao
Chongqing institute of Population and Family Planning, Key Laboratory of Birth Defects and Reproductive Health, Chongqing, 400020, China.
Lianbing
L
Li
Chongqing institute of Population and Family Planning, Key Laboratory of Birth Defects and Reproductive Health, Chongqing, 400020, China.
Zhiwei
Z
Hou
Chongqing institute of Population and Family Planning, Key Laboratory of Birth Defects and Reproductive Health, Chongqing, 400020, China.
Danyan
D
Zhang
Chongqing institute of Population and Family Planning, Key Laboratory of Birth Defects and Reproductive Health, Chongqing, 400020, China.
Ling
L
Wan
Chongqing institute of Population and Family Planning, Key Laboratory of Birth Defects and Reproductive Health, Chongqing, 400020, China.
Li
L
Wei
Chongqing institute of Population and Family Planning, Key Laboratory of Birth Defects and Reproductive Health, Chongqing, 400020, China.
Yuyou
Y
Yang
Chongqing institute of Population and Family Planning, Key Laboratory of Birth Defects and Reproductive Health, Chongqing, 400020, China.
Jing
J
Lv
Chongqing institute of Population and Family Planning, Key Laboratory of Birth Defects and Reproductive Health, Chongqing, 400020, China. mamf123@163.com.
Mingfu
M
Ma
Chongqing institute of Population and Family Planning, Key Laboratory of Birth Defects and Reproductive Health, Chongqing, 400020, China. zyjlife@163.com.
Yijian
Y
Zhu
D000328:Adult; D002681:China; D003430:Cross-Sectional Studies; D005640:Follicle Stimulating Hormone / Q000097:blood; D015658:HIV Infections / Q000503:physiopathology*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D019216:Metals, Heavy / Q000032:analysis* / Q000097:blood / Q000652:urine; D055101:Semen Analysis; D013739:Testosterone / Q000097:blood; D019562:Viral Load
D019216:Metals, Heavy; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Heavy metal; Hormone; Human immunodeficiency virus; Semen quality