Eosinophilic Dermatosis of Hematologic Malignancy.
Dermatosis characterized by tissue eosinophilia arising in the context of hematologic disease is known as eosinophilic dermatosis of hematologic malignancy. The most commonly associated malignancy is chronic lymphocytic leukemia. Eosinophilic dermatosis of hematologic malignancy is a rare condition with a wide variety of clinical presentations, ranging from papules, erythematous nodules, or blisters that simulate arthropod bites, to the formation of true plaques of differing sizes. Histology reveals the presence of abundant eosinophils. We present 4 new cases seen in Hospital Arnau de Vilanova, Valencia, during the past 7 years. Three of these cases were associated with chronic lymphocytic leukemia and 1 with mycosis fungoides. It is important to recognize this dermatosis as it can indicate progression of the underlying disease, as was the case in 3 of our patients.
Servicio de Dermatología, Hospital Arnau de Vilanova, Valencia, España. Electronic address: sofialucas89@gmail.com.
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S
Lucas-Truyols
Servicio de Dermatología, Consorcio Hospital Provincial de Castellón, Castellón de la Plana, España.
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B
Rodrigo-Nicolás
Servicio de Dermatología, Hospital Arnau de Vilanova, Valencia, España.
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C
Lloret-Ruiz
Servicio de Dermatología, Hospital Arnau de Vilanova, Valencia, España.
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Quecedo-Estébanez
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D000077610:Bexarotene; D003872:Dermatitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003937:Diagnosis, Differential; D018450:Disease Progression; D004802:Eosinophilia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D007299:Insect Bites and Stings / Q000175:diagnosis; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications* / Q000188:drug therapy; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D012189:Retrospective Studies; D013764:Tetrahydronaphthalenes / Q000009:adverse effects / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D013764:Tetrahydronaphthalenes; D000077610:Bexarotene
Chronic lymphocytic leukemia; Dermatosis eosinofílica; Eosinofilia tisular; Eosinophilic dermatosis; Insect bites; Leucemia linfática crónica; Micosis fungoide; Mycosis fungoides; Picaduras; Tissue eosinophilia