Invited review: Milk phospholipid vesicles, their colloidal properties, and potential as delivery vehicles for bioactive molecules.
The milk fat globule membrane (MFGM) is a unique colloidal assembly of phospholipids and proteins, with numerous potential applications as functional ingredient. The phospholipid components of the MFGM are gaining interest as they are a useful matrix for use as a constituent of delivery systems such as liposomes. Liposomes formulated with milk phospholipids are becoming an alternative to other sources of phospholipids such as soybean or egg yolk. However, incorporation of phospholipids fractionated from the milk fat globule membrane in dairy products requires an in-depth understanding of the functional properties of phospholipids. In particular, it is critical to understand which factors play a role in their stability and bioefficacy as delivery systems. Moreover, chemical and physical modifications of phospholipid liposomes occurring during digestion and the fate of the encapsulated compounds are very important to understand. This review discusses recent findings on the structure and functionality of MFGM, the bioactivity of the phospholipids fraction, their utilization as delivery systems, and their stability through gastrointestinal transit.
Department of Food Science, University of Guelph, Guelph, ON, N1G 2W1, Canada.
E
E
Arranz
Department of Food Science, University of Guelph, Guelph, ON, N1G 2W1, Canada; Gay Lea Foods, Research and Development, Speedvale Avenue W, Guelph, ON, N1H 1J5, Canada. Electronic address: mcorredi@uoguelph.ca.
M
M
Corredig
D000818:Animals; D003102:Colloids; D004063:Digestion; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D006017:Glycolipids / Q000737:chemistry*; D006023:Glycoproteins / Q000737:chemistry*; D066292:Lipid Droplets; D008081:Liposomes; D010743:Phospholipids / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism
D003102:Colloids; D004337:Drug Carriers; D006017:Glycolipids; D006023:Glycoproteins; D008081:Liposomes; D010743:Phospholipids; C110367:milk fat globule
bioactivity; gastrointestinal tract; liposome; milk fat globule membrane; polar lipid