A Novel Point-of-Care Smartphone Based System for Monitoring the Cardiac and Respiratory Systems.
Cardio-respiratory monitoring is one of the most demanding areas in the rapidly growing, mobile-device, based health care delivery. We developed a 12-lead smartphone-based electrocardiogram (ECG) acquisition and monitoring system (called "cvrPhone"), and an application to assess underlying ischemia, and estimate the respiration rate (RR) and tidal volume (TV) from analysis of electrocardiographic (ECG) signals only. During in-vivo swine studies (n = 6), 12-lead ECG signals were recorded at baseline and following coronary artery occlusion. Ischemic indices calculated from each lead showed statistically significant (p < 0.05) increase within 2 min of occlusion compared to baseline. Following myocardial infarction, spontaneous ventricular tachycardia episodes (n = 3) were preceded by significant (p < 0.05) increase of the ischemic index ~1-4 min prior to the onset of the tachy-arrhythmias. In order to assess the respiratory status during apnea, the mechanical ventilator was paused for up to 2 min during normal breathing. We observed that the RR and TV estimation algorithms detected apnea within 7.9 ± 1.1 sec and 5.5 ± 2.2 sec, respectively, while the estimated RR and TV values were 0 breaths/min and less than 100 ml, respectively. In conclusion, the cvrPhone can be used to detect myocardial ischemia and periods of respiratory apnea using a readily available mobile platform.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Kwanghyun
K
Sohn
Cardiology Division, Emory University School of Medicine, Atlanta, GA, USA.
Faisal M
FM
Merchant
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Omid
O
Sayadi
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Dheeraj
D
Puppala
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Rajiv
R
Doddamani
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Ashish
A
Sahani
Cardiology Division, Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA.
Jagmeet P
JP
Singh
Cardiology Division, Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA.
E Kevin
EK
Heist
Healthcare Transformation Lab, Massachusetts General Hospital, Boston, MA, USA.
Eric M
EM
Isselbacher
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.|Institute for Medical Engineering and Science, Massachusetts Institute of Technology Cambridge, MA, USA.
Antonis A
AA
Armoundas
D000465:Algorithms; D000818:Animals; D004562:Electrocardiography / Q000295:instrumentation* / Q000379:methods*; D006321:Heart / Q000503:physiopathology*; D006334:Heart Function Tests / Q000295:instrumentation / Q000379:methods; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods*; D019095:Point-of-Care Systems; D012129:Respiratory Function Tests / Q000295:instrumentation / Q000379:methods; D012137:Respiratory System / Q000503:physiopathology*; D000068997:Smartphone; D013552:Swine