Prognostic impact of GATA binding protein-3 expression in primary lung adenocarcinoma.
GATA binding protein-3 (GATA3) is a transcription factor that regulates cell differentiation and maintenance in some types of normal cells. This study aimed to investigate the association between GATA3 expression and primary lung adenocarcinoma and to clarify the clinical significance of GATA3 expression in lung adenocarcinoma. Immunohistochemical GATA3 expression was evaluated using completely resected lung adenocarcinoma samples from 95 cases. GATA3 immunohistochemical staining was performed and scored. Associations between clinicopathological factors and GATA3 expression were analyzed by using the χ2test and Fisher exact test. The Kaplan-Meier method was used to analyze overall survival (OS) and disease-free survival (DFS). Forty-nine cases expressed high levels of GATA3, which were associated with lymphatic invasion (P=.003). In univariate and multivariate analyses, vascular invasion (P<.001) and high GATA3 expression (P=.023) were identified as independent risk factors for OS. Higher pathological stages (P=.012), vascular invasion (P=.010), and high GATA3 expression (P=.009) were identified as independent risk factors for DFS. The high GATA3 expression group exhibited statistically worse OS (P=.031) and DFS (P=.011) than the low-expression group based on the Kaplan-Meier curves. In resected lung adenocarcinoma, high GATA3 expression is associated with poorer prognosis for both OS and DFS. Therefore, the immunohistochemical evaluation of GATA3 represents a potentially useful prognostic tool for postoperative patients.
Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan; Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Toshihiro
T
Hashiguchi
Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan. Electronic address: miyoshi_hiroaki@med.kurume-u.ac.jp.
Hiroaki
H
Miyoshi
Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Kazutaka
K
Nakashima
Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Shintaro
S
Yokoyama
Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Ryoichi
R
Matsumoto
Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Daigo
D
Murakami
Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Masahiro
M
Mitsuoka
Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Shinzo
S
Takamori
Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Yoshito
Y
Akagi
Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Koichi
K
Ohshima
D000072283:A549 Cells; D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000556:secondary / Q000601:surgery; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001706:Biopsy; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D005260:Female; D050990:GATA3 Transcription Factor / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011013:Pneumonectomy; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation
D014408:Biomarkers, Tumor; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human
Adenocarcinoma; GATA3; Immunohistochemistry; Lung; Prognosis