Animal Models and Antifungal Agents in Paracoccidioidomycosis: An Overview.
Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis, the most prevalent systemic mycosis in Latin America. The morbidity and mortality associated with paracoccidioidomycosis necessitate our understanding of fungal pathogenesis and discovering of new agents to treat this infection. Animal models have contributed much to the knowledge of fungal infections and their corresponding therapeutic treatments. This is true for animal models of the primary fungal pathogens such as P. brasiliensis. This review describes the development, details and utility of animal models of paracoccidioidomycosis for studying and developing the current antifungal agents used for therapy of this fungal disease and novel agents with antifungal properties against P. brasiliensis.
Section of Infectious Diseases, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, Porto Alegre, RS, 90640-000, Brazil. Lgoldani@ufrgs.br.
Luciano Z
LZ
Goldani
Section of Infectious Diseases, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, Porto Alegre, RS, 90640-000, Brazil.
Fernanda
F
Wirth
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D010229:Paracoccidioidomycosis / Q000188:drug therapy* / Q000473:pathology*
D000935:Antifungal Agents
Animal model; Antifungal agents; Experimental paracoccidioidomycosis; Paracoccidioides brasiliensis