The medicinal plants in the control of tuberculosis: Laboratory study on medicinal plants from the Northern Area of Pakistan.
Tuberculosis (TB) ranks as the second leading cause of deaths due to infectious diseases. Although global efforts have been made to control TB, still, this is a serious threat as Mycobacterium tuberculosis (MTB) produced resistance against both the first- and second-line drugs. The increasing incidence of multidrug-resistant, extremely drug resistant, and totally drug-resistant TB worldwide requires extra efforts to search for new anti-TB drugs.



The present study evaluated the antimycobacterial activities of Citrullus colocynthis, Calotropis procera, Ricinus communis, Capparis decidua, and Fagonia cretica plants' extracts against rifampicin-sensitive (H37Rv) and rifampicin-resistant (TMC331) strains of MTB.



Out of 44 extracts, 19 extracts were found active against H37Rv sensitive strain. Highest activities were observed in chloroform extract of C. colocynthis (leaves) and n-hexane extract of R. communis (seeds) with minimum inhibitory concentration values of 2.5 mg/ml each.



Results show antimycobacterial potential in some of the fractions of studied plants that may be utilized further for isolation of active compounds and as a possible cure against TB.
Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Pakistan.
Sami
S
Ullah
Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Pakistan.
Shah
S
Hussain
Department of Medical Lab Technology, University of Haripur, Haripur, Pakistan.
Sadiq Noor
SN
Khan
Department of Pharmacy, Shaheed Benazir Bhutto University, Sheringal, Pakistan.
Mohammad
M
Khurram
Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Pakistan.
Iqbal
I
Khan
Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Pakistan.
Murad Ali
MA
Khan
D000995:Antitubercular Agents / Q000494:pharmacology*; D031107:Calotropis / Q000737:chemistry; D002725:Chloroform; D029773:Citrullus / Q000737:chemistry; D055808:Drug Discovery; D024881:Drug Resistance, Bacterial; D006586:Hexanes; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010154:Pakistan; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012278:Ricinus / Q000737:chemistry; D012293:Rifampin / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D014376:Tuberculosis / Q000188:drug therapy / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000382:microbiology
D000995:Antitubercular Agents; D006586:Hexanes; D010936:Plant Extracts; C026385:n-hexane; D002725:Chloroform; D012293:Rifampin