Case Report: Immune-mediated Complete Response in a Patient With Recurrent Advanced Ewing Sarcoma (EWS) After Vigil Immunotherapy.
Ewing sarcoma is a highly resistant disease with a <10% chance of survival at 5 years after failure of frontline chemotherapy. This is a case report of an Ewing sarcoma patient with metastatic disease recurrence <2 years after standard chemotherapy/radiation who achieved a durable and sustained complete response after 2 series of treatments with Vigil (GMCSF/bi-shRNA furin DNA autologous tumor immunotherapy) serially manufactured from first and second recurrences with ELISPOT assay correlation. Results support justification of further testing of Vigil with ELISPOT assay as a biomarker to assess level of immune response and correlation with disease control.
*Mary Crowley Cancer Research Centers †Texas Oncology, P.A. ‡Medical City Dallas Hospital ∥ProPath ¶Gradalis Inc. #Strike Bio, Dallas, TX §Foundation Medicine, Cambridge, MA.
Maurizio
M
Ghisoli
McCarley
M
Rutledge
Philip J
PJ
Stephens
Robert
R
Mennel
Minal
M
Barve
Meghan
M
Manley
Bahram R
BR
Oliai
Kathleen M
KM
Murphy
Luisa
L
Manning
Belen
B
Gutierrez
Priyanka
P
Rangadass
Ashli
A
Walker
Zhaohui
Z
Wang
Donald
D
Rao
Ned
N
Adams
Gladice
G
Wallraven
Neil
N
Senzer
John
J
Nemunaitis
D000293:Adolescent; D001559:Benzhydryl Compounds / Q000008:administration & dosage* / Q000627:therapeutic use; D019496:Cancer Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use; D058501:Enzyme-Linked Immunospot Assay; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D000077408:Modafinil; D034741:RNA, Small Interfering / Q000627:therapeutic use; D016879:Salvage Therapy / Q000379:methods; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome
D001559:Benzhydryl Compounds; D019496:Cancer Vaccines; C573235:FANG vaccine; D034741:RNA, Small Interfering; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D000077408:Modafinil