The Effect of Ineffective Esophageal Motility on Gastroesophageal Reflux Disease.
OBJECTIVE
Ineffective esophageal motility (IEM) is the most common gastrointestinal motility disorder. Studies have reported that IEM is related to gastroesophageal reflux disease (GERD). However, the relationship between IEM and GERD remains uncertain. This study aims to clarify this relationship retrospectively.


METHODS
We analyzed 195 subjects who underwent high-resolution manometry between January 2011 and September 2016. Of these subjects, 72 had normal esophageal motility (NEM) and 26 had IEM. We investigated differences in the clinical characteristics, severity and duration of GERD symptoms, and comorbid extra-esophageal symptoms of the subjects. Comorbid extra-esophageal symptoms were assessed with the Gastrointestinal Symptom Rating Scale questionnaire. Investigation-defined GERD was diagnosed when erosive esophagitis or abnormal multichannel intraluminal impedance was present.


RESULTS
We found no significant difference in the prevalence of IEM between patients with and without GERD (37.5 and 21.1%, respectively; p = 0.174). There were no differences in age, gender, body mass index, presence of hiatal hernia, or duration of GERD between the groups. Compared to patients with NEM, those with IEM were significantly less likely to have comorbid extra-esophageal symptoms (p < 0.05).


CONCLUSIONS
There is no association between IEM and GERD.
Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Shingo
S
Kasamatsu
Tomoaki
T
Matsumura
Yuki
Y
Ohta
Shinsaku
S
Hamanaka
Hideaki
H
Ishigami
Takashi
T
Taida
Kenichiro
K
Okimoto
Keiko
K
Saito
Daisuke
D
Maruoka
Tomoo
T
Nakagawa
Tatsuro
T
Katsuno
Mai
M
Fujie
Atsuko
A
Kikuchi
Makoto
M
Arai
D000368:Aged; D015897:Comorbidity; D017097:Electric Impedance; D015154:Esophageal Motility Disorders / Q000175:diagnosis / Q000453:epidemiology*; D050782:Esophageal pH Monitoring / Q000379:methods; D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000453:epidemiology*; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000453:epidemiology*; D006551:Hernia, Hiatal / Q000453:epidemiology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008365:Manometry / Q000379:methods; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012720:Severity of Illness Index
Gastroesophageal reflux disease; High-resolution manometry; Ineffective esophageal motility