Sarcophytrols G - L, Novel Minor Metabolic Components from South China Sea Soft Coral Sarcophyton trocheliophorum Marenzeller.
Minor metabolic components, six new cembranoids sarcophytrols G - L (1 - 6) along with two known related analogues 7 and 8, were isolated from the South China Sea soft coral Sarcophyton trocheliophorum. Their structures were elucidated by extensive spectroscopic analyses (1D-, 2D-NMR, and ESI-MS) as well as comparison with literature data. As part of our ongoing research project for discovering bioactive substances from Chinese marine invertebrates, compounds 1 - 8 were tested for their inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of Type-II diabetes and obesity. However, none of them exhibited potent PTP1B inhibitory activities.
College of Material Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, P. R. China.|State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech park, Shanghai, 201203, P. R. China.
Lin-Fu
LF
Liang
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech park, Shanghai, 201203, P. R. China.
Wen-Ting
WT
Chen
Institute of Biomolecular Chemistry (ICB)-CNR, Via Campi Flegrei, 34, IT-80078, Pozzuoli, Naples.
Ernesto
E
Mollo
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech park, Shanghai, 201203, P. R. China.
Li-Gong
LG
Yao
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech park, Shanghai, 201203, P. R. China.
He-Yao
HY
Wang
Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, 222001, P. R. China.
Wei
W
Xiao
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech park, Shanghai, 201203, P. R. China.
Yue-Wei
YW
Guo
D000818:Animals; D037421:Anthozoa / Q000737:chemistry / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D002681:China; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D013057:Spectrum Analysis
D000970:Antineoplastic Agents; D004224:Diterpenes; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1

Sarcophyton trocheliophorum
; PTP1B inhibitory activities; Soft coral; Structure elucidation; Terpenoids