Case of bullous pemphigoid coexisting with anti-desmoglein autoantibodies.
A 79-year-old Japanese woman had clinical and histopathological features of bullous pemphigoid, while direct immunofluorescence test revealed C3 and immunoglobulin G depositions in the lower cell surfaces of the epidermis in addition to those in the dermoepidermal junction. Chemiluminescent enzyme immunoassays were positive for desmoglein-1 and -3 antibodies in addition to anti-BP180 antibodies. In an immunoblotting study, antibodies against both 180-kDa bullous pemphigoid antigen and 130-kDa pemphigus vulgaris antigen were detected. Based on these results, bullous pemphigoid coexisting with anti-desmoglein autoantibodies was diagnosed in this case.
Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan.
Duerna
D
Tie
Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan.
Tokiko
T
Yoshida
Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan.
Yuko
Y
Chinuki
Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan.
Xia
X
Da
Department of Pathology, Shimane University Faculty of Medicine, Izumo, Japan.
Noriyoshi
N
Ishikawa
Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan.
Eishin
E
Morita
D000279:Administration, Cutaneous; D000368:Aged; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001706:Biopsy; D003176:Complement C3 / Q000032:analysis; D020405:Dermis / Q000276:immunology / Q000473:pathology; D051183:Desmoglein 1 / Q000276:immunology*; D051184:Desmoglein 3 / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D004817:Epidermis / Q000276:immunology / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000032:analysis; D018655:Lymphocyte Count; D024041:Non-Fibrillar Collagens / Q000276:immunology; D009824:Ointments; D010391:Pemphigoid, Bullous / Q000097:blood / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D010976:Platelet Count; D011239:Prednisolone / Q000627:therapeutic use; D000097805:Collagen Type XVII
D001323:Autoantibodies; D001324:Autoantigens; D003176:Complement C3; D051183:Desmoglein 1; D051184:Desmoglein 3; D005938:Glucocorticoids; D007074:Immunoglobulin G; D024041:Non-Fibrillar Collagens; D009824:Ointments; D011239:Prednisolone; D000097805:Collagen Type XVII; C495297:DSG1 protein, human; C071894:DSG3 protein, human
anti-BP180 antibodies; anti-desmoglein antibodies; bullous pemphigoid; immunoblotting; pemphigus