Is there a role of magnetic resonance imaging in deciding to stop anti-tumor necrosis factor treatment in ileal Crohn's disease?
OBJECTIVE
This study was performed to assess the ability of magnetic resonance enterography to predict the evolution of patients in whom anti-tumor necrosis factor-α therapy was suspended.


METHODS
A prospective study of patients with ileal Crohn's disease was performed.


RESULTS
Twenty-nine patients were included. Patients who later relapsed showed higher magnetic resonance scores than those who did not relapse (4.2 vs. 2.5, respectively; p<0.02). The area under the receiving-operating characteristics curve was 0.755 when discriminating patients who relapsed.


CONCLUSIONS
Magnetic resonance enterography should be taken into account when deciding the withdrawal of anti-tumor necrosis factor-α in patients with Crohn's disease.
Radiology Department, Complexo Hospitalario Universitario de Ferrol, Ferrol, Spain. Electronic address: josecarlos.gallego.ojea@sergas.es.
Jose C
JC
Gallego
Gastroenterology Department, Complexo Hospitalario Universitario de Ferrol, Ferrol, Spain.
Ana
A
Echarri
D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D003424:Crohn Disease / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007082:Ileum / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*; D055815:Young Adult
D014409:Tumor Necrosis Factor-alpha
Anti-tumor necrosis factor agents; Crohn's disease; Magnetic resonance imaging