In situ deprotection and dynamic covalent assembly using a dual role catalyst.
Utilization of constituent molecular precursors bearing covalently coreactive functional groups for self-assembly risks premature reaction, impeding synthetic and purification efforts. To prevent premature amine-aldehyde condensation for oligomers bearing both groups, we employ a dual-role Lewis acid catalyst for both in situ acetal deprotection and subsequent imine exchange, effecting oligomer assembly.
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. tfscott@umich.edu.
T
http://orcid.org/0000-0001-8923-293X
T
Wei
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. tfscott@umich.edu.
J C
http://orcid.org/0000-0002-7040-0793
JC
Furgal
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. tfscott@umich.edu and Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
T F
http://orcid.org/0000-0002-5893-3140
TF
Scott