Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review.
Dihydropyrimidines are the most important heterocyclic ring systems which play an important role in the synthesis of DNA and RNA. Synthetically they were synthesized using Multi-component reactions like Biginelli reaction and Hantzschdihydropyridine. In the past decades, such Biginelli type dihydropyrimidones have received a considerable amount of attention due to the interesting pharmacological properties associated with this heterocyclic scaffold. In this review, we highlight recent developments in this area, with a focus on the DHPMs, recently developed as anti-inflammatory, anti-HIV, anti-tubercular, antifungal anticancer, antibacterial, antifilarial, antihyperglycemic, antihypertensive, analgesic, anti-convulsant, antioxidant, anti-TRPA1, anti-SARS, and anti-cancer activity and α1abinding affinity.
Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy (ISFCP), Moga 142001, India.
Ramandeep
R
Kaur
Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy (ISFCP), Moga 142001, India.
Sandeep
S
Chaudhary
Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy (ISFCP), Moga 142001, India.
Kapil
K
Kumar
School of Pharmacy, Lloyd Institute of Management and Technology, Greater Noida 203207, India.
Manish K
MK
Gupta
Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy (ISFCP), Moga 142001, India. Electronic address: rawal.ravindra@gmail.com.
Ravindra K
RK
Rawal
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D000969:Antinematodal Agents / Q000138:chemical synthesis; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D000975:Antioxidants / Q000138:chemical synthesis; D000998:Antiviral Agents / Q000138:chemical synthesis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000969:Antinematodal Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D000998:Antiviral Agents; D006571:Heterocyclic Compounds; D011744:Pyrimidinones
Anti-HIV; Anticancer; Biginelli reaction; Dihydropyrimidinones; Hantzsch