Recurrent Mixed Cryoglobulinemia Despite Sustained Virologic Response to Treatment: A Case Report.
Cryoglobulinemia is a manifestation of hepatitis C virus (HCV) infection. Treatment of HCV is the mainstay of therapy for mixed cryoglobulinemia syndrome, and newer HCV therapies with direct-acting antiviral agents have achieved great success in treating HCV infection compared with pegylated interferon alfa and ribavirin. Recurrence of mixed cryoglobulinemia syndrome following successful treatment with direct-acting antiviral agents is uncommon, and when it occurs, it is most often due to relapse of HCV viremia. We report a case of recurrent mixed cryoglobulinemia syndrome following HCV treatment with a new direct-acting antiviral agent (sofosbuvir) and ribavirin, in which HCV RNA was undetectable in serum, but detectable in the cryoprecipitate.
Dallas Nephrology Associates, Dallas, TX. Electronic address: chowdhuryr@dneph.com.
Renuka
R
Chowdhury
University of Texas Health Science Center at San Antonio, San Antonio, TX. Electronic address: adriannetsen@gmail.com.
Adrianne
A
Tsen
D000998:Antiviral Agents / Q000627:therapeutic use*; D003449:Cryoglobulinemia / Q000188:drug therapy* / Q000821:virology*; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012254:Ribavirin / Q000627:therapeutic use*; D000069474:Sofosbuvir / Q000627:therapeutic use*; D000072230:Sustained Virologic Response
D000998:Antiviral Agents; D012254:Ribavirin; D000069474:Sofosbuvir
HCV RNA; Recurrent mixed cryoglobulinemia syndrome; case report; cryoprecipitate; direct antiviral agents; hepatitis C virus (HCV); kidney biopsy; membranoproliferative glomerulonephritis; renal involvement; sofosbuvir; sustained virological response (SVR); viral load