Bapx1 mediates transforming growth factor-β- induced epithelial-mesenchymal transition and promotes a malignancy phenotype of gastric cancer cells.
The homeoprotein Bapx1 is an important regulator of gastroduodenal tract morphogenesis. Here, we investigated how Bapx1 influences gastric cancer (GC) prognosis and elucidated the underlying mechanisms. Bapx1 expression was greater in GC tissues compared to adjacent non-tumor tissues and expression was positively correlated with mortality, lymph node and distance metastasis. Silencing Bapx1 diminished cell invasion/migration and decreased mesenchymal phenotypes. Transforming growth factor-β (TGF-β) induced Bapx1 expression and epithelial-mesenchymal transition (EMT) in GC cells. However, down-regulated Bapx1 reversed TGF-β induced invasion, migration, morphological changes, and EMT. In summary, Bapx1 indicates poor prognosis for GC by promoting tumor migration and invasion via TGF-β-induced EMT.
Department of Oncology, Nanfang Hospital, Southern Medical University Guangzhou, 510515, China; Key Laboratory of Liver Disease, Center of Infectious Diseases, PLA 458 Hospital, Guangzhou, 510602, China.
Shi
S
Ouyang
Department of Oncology, Nanfang Hospital, Southern Medical University Guangzhou, 510515, China; Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, 510180, China.
Guodong
G
Zhu
Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Lei
L
Ouyang
Department of Oncology, Nanfang Hospital, Southern Medical University Guangzhou, 510515, China.
Yuhao
Y
Luo
Department of Oncology, Nanfang Hospital, Southern Medical University Guangzhou, 510515, China.
Rui
R
Zhou
Department of Oncology, Nanfang Hospital, Southern Medical University Guangzhou, 510515, China.
Changqie
C
Pan
Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Jianping
J
Bin
Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yulin
Y
Liao
Department of Oncology, Nanfang Hospital, Southern Medical University Guangzhou, 510515, China. Electronic address: nfyyliaowj@163.com.
Wangjun
W
Liao
D000368:Aged; D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D002460:Cell Line; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D018398:Homeodomain Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D016019:Survival Analysis; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism / Q000494:pharmacology*; D014746:Vimentin / Q000235:genetics / Q000378:metabolism; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
D015703:Antigens, CD; C513384:CDH1 protein, human; C495270:CTNNB1 protein, human; D015820:Cadherins; D018398:Homeodomain Proteins; C491536:NKX3-2 protein, human; D034741:RNA, Small Interfering; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D014746:Vimentin; D051176:beta Catenin; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
Bapx1; Epithelial-mesenchymal transition; Gastric cancer; TGF-β