Distribution and levels of 5-HT1Breceptors in anterior cingulate cortex of patients with bipolar disorder, major depressive disorder and schizophrenia - An autoradiography study.
The serotonin 1B receptor has recently received more interest as a possible new target for pharmacological treatment of psychiatric disorders. However, the exact mechanisms of action remain unclear. This study aimed to examine the binding distribution and levels of the serotonin 1B receptor in-depth in the anterior cingulate cortex (ACC) and provide more insight in its functional role in bipolar disorder (BD), major depressive disorder (MDD) and schizophrenia (SZ). Serotonin 1B receptor binding distribution was visualized with high resolution autoradiography (ARG), using the radioligand [3H]AZ10419369, in postmortem ACC tissue from patients diagnosed with BD (n=14), MDD (n=12), SZ (n=13) and healthy subjects (n=13). Moreover, a quantification of receptor binding was made with ARG, in relation to patient group, age and gender. In all subject groups a significantly higher specific binding of serotonin 1B receptor was measured in the outer ACC layers compared to the inner ACC layers. Correlation analysis with ARG binding patterns of several radioligands resulted in a significant correlation with glutamatergic N-methyl-D-aspartate receptor binding in the outer layers. No significant difference was found between subject groups in binding levels and distribution. In female subjects a significantly lower receptor binding was found than in male subjects, which was most profound in patients diagnosed with MDD. The binding distribution of the serotonin 1B receptor found in this study supports a role in glutamate transmission in the ACC and was not shown to be significantly altered in BD, MDD or SZ. A gender difference in serotonin 1B receptor binding was found.
Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden. Electronic address: Emma.Veldman@ki.se.
Emma R
ER
Veldman
Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Marie M
MM
Svedberg
Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Per
P
Svenningsson
Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Johan
J
Lundberg
D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D001345:Autoradiography; D001714:Bipolar Disorder / Q000473:pathology*; D003865:Major Depressive Disorder / Q000473:pathology*; D003933:Diagnosis; D005260:Female; D006179:Gyrus Cinguli / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011485:Protein Binding / Q000187:drug effects; D044302:Receptor, Serotonin, 5-HT1B / Q000378:metabolism*; D012559:Schizophrenia / Q000473:pathology*; D017366:Serotonin Receptor Agonists / Q000493:pharmacokinetics; D012737:Sex Factors; D014316:Tritium / Q000493:pharmacokinetics
D044302:Receptor, Serotonin, 5-HT1B; D017366:Serotonin Receptor Agonists; D014316:Tritium
Anterior cingulate cortex; Autoradiography; Bipolar disorder; Major depressive disorder; Schizophrenia; Serotonin 1B receptor