An anti-inflammatory dietary intervention to reduce breast cancer recurrence risk: Study design and baseline data.
U.S. breast cancer survivors (BCSs) are expected to increase to 4 million in the next 5-10years. Cancer recurrence risk is highest among obese survivors. Inflammatory (Pro-I) biomarkers including C-reactive protein (CRP), Interleukins -3, -6, and -8 (IL-3, IL-6, IL-8), and Tumor Necrosis Factor (TNF)-α have been associated with cancer recurrence risk. Nutritional interventions aimed at reducing inflammation (INF) may contribute to reduced cancer recurrence risk, but studies have been limited to animal models. The goals of this one-year, culinary-based, pilot intervention were to: 1) decrease Pro-I biomarkers and increase anti-inflammatory (AI) cytokine, IL-10, by promoting AI food incorporation into BCS diets; and 2) examine intervention effects on cancer risk factors including body mass index (BMI) and circulating adipose stromal cells (ASCs). A total of 153 BCSs were recruited. Overweight and obese women aged 18 or older were randomized into Intervention (IG; n=76) and Control (CG; n=77) groups. CG received monthly nutritional brochures from the American Institute for Cancer Research. IG attended 6 monthly workshops (lectures on AI topics and chef-prepared food demonstrations), and received monthly newsletters and telephone calls incorporating Motivational Interviewing. At baseline, 6- and 12-month assessments, fasting serum was assayed for Pro-I/AI marker and ASC levels. Using R and Stata version 14 (Stata Corp, 2015), no significant differences were found between groups on baseline demographic variables. Correlations between serum cytokine levels, BMI, % body fat, ASCs, and self-reported variables are discussed.
Department of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, USA. Electronic address: ramirezag@uthscsa.edu.
Amelie G
AG
Ramirez
Department of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, USA.
Dorothy Long
DL
Parma
Department of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, USA.
Edgar
E
Muñoz
Department of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, USA.
Kristin D
KD
Mendoza
Department of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, USA.
Crystel
C
Harb
Department of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, USA.
Alan E C
AEC
Holden
Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, USA.
Michael
M
Wargovich
D000273:Adipose Tissue / Q000166:cytology; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000178:diet therapy / Q000517:prevention & control*; D002097:C-Reactive Protein / Q000032:analysis; D002452:Cell Count; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D007378:Interleukins / Q000097:blood; D008875:Middle Aged; D062405:Motivational Interviewing; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D055502:Secondary Prevention / Q000379:methods; D017154:Stromal Cells; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D015415:Biomarkers; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002097:C-Reactive Protein
Biomarker; Breast cancer survivors; Inflammation; Obesity