Temporal changes in plasma markers of oxidative stress following laparoscopic sleeve gastrectomy in subjects with impaired glucose regulation.
BACKGROUND
Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for obesity and associated metabolic complications. Obesity and type 2 diabetes are associated with increased oxidative stress. Previous studies have examined changes in plasma oxidative stress after laparoscopic Roux-en-Y gastric bypass, but there is limited evidence of the effects of LSG.


OBJECTIVE
To examine the effects of LSG on plasma thiobarbituric acid reactive substances (TBARS) and total antioxidant status (TAOS) at 1 and 6 months after LSG in patients with obesity and impaired glucose regulation.


METHODS
University hospital, United Kingdom.


METHODS
Twenty-two participants with impaired glucose homeostasis undergoing LSG (body mass index 50.1 kg/m2, glycated hemoglobin 53 mmol/mol) were studied. Measurements of fasting and 120-minute TBARS and TAOS were performed during an oral glucose tolerance test preoperatively and postoperatively.


RESULTS
Compared with preoperative levels, significant decreases were seen 6 months postoperatively in fasting TBARS (61.0±17.9 versus 39.4±13.8 ng/mL, P = .04) and 120-minute TBARS (76.0±29.5 versus 46.5±16.3 ng/mL, P = .02). No significant changes were observed in plasma TAOS. No significant association was observed between changes in TBARS and other clinical or biochemical measures.


CONCLUSIONS
We observed a significant reduction in TBARS, a global measure of lipid peroxidation 6 months after LSG in participants with obesity and impaired glucose regulation.
Diabetes Research Group, Medical School, Swansea University, Swansea, United Kingdom.
Sarah L
SL
Prior
Welsh Institute of Metabolic and Obesity Surgery, Morriston Hospital, ABMU Health Board, Swansea, United Kingdom.
Jonathan D
JD
Barry
Welsh Institute of Metabolic and Obesity Surgery, Morriston Hospital, ABMU Health Board, Swansea, United Kingdom.
Scott
S
Caplin
Diabetes Research Group, Medical School, Swansea University, Swansea, United Kingdom.
Thinzar
T
Min
Diabetes Research Group, Medical School, Swansea University, Swansea, United Kingdom.
Danielle A
DA
Grant
Diabetes Research Group, Medical School, Swansea University, Swansea, United Kingdom; Welsh Institute of Metabolic and Obesity Surgery, Morriston Hospital, ABMU Health Board, Swansea, United Kingdom. Electronic address: j.w.stephens@swansea.ac.uk.
Jeffrey W
JW
Stephens
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000601:surgery; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D018149:Glucose Intolerance / Q000097:blood / Q000601:surgery; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000601:surgery; D018384:Oxidative Stress / Q000502:physiology*; D011182:Postoperative Care; D011446:Prospective Studies; D013858:Thiobarbiturates / Q000378:metabolism*; D055815:Young Adult
D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D013858:Thiobarbiturates
Laparoscopic sleeve gastrectomy; Obesity; Oxidative stress; Type 2 diabetes