Association between resting heart rate just before starting the first dialysis session and mortality: A multicentre prospective cohort study.
OBJECTIVE
Some observational studies of the general population showed that resting heart rate was associated with mortality. However, the relationship was unclear in dialysis patients.


METHODS
The study was a multicentre prospective cohort analysis including 1102 patients. Patients were classified into four groups based on resting heart rate just before starting the first dialysis session: <60/min; 60-79/min; 80-100/min; and ≥101/min. All-cause mortality, cardiovascular (CV) related mortality, and incidences of CV events after dialysis initiation were compared using the log-rank test. All-cause mortality rates for patients with heart rates <60, 60-79, and ≥101/min were compared to those for patients with heart rates 80-100/min, using multivariate Cox proportional hazard regression analysis. Moreover, we compared the outcomes among patients without use of β-blocker or heart failure symptom at the first dialysis session.


RESULTS
Significant differences were observed in the all-cause mortality rates among the four groups (P = 0.007). Multivariate analysis revealed that all-cause mortality was significantly higher in patients with heart rate ≥ 101/min than in patients with heart rate 80-100/min (hazard ratio [HR] = 2.30, 95% confidence interval [CI]: 1.25-4.23). Subgroup analysis showed that among patients without use of b-blocker or heart failure symptom, all-cause mortality rates for those with heart rates ≥101/min were significantly higher than in patients with heart rate 80-100/min (HR = 2.98, 95% CI: 1.51-5.88, HR = 3.65, 95% CI: 1.59-8.36, respectively).


CONCLUSIONS
The resting heart rate just before starting the first dialysis session was associated with all-cause mortality after dialysis initiation.
Fujita Health University School of Medicine, Toyoake, Aichi, Japan.|The Aichi Cohort Study of Prognosis in Patients Newly Initiated Into Dialysis (AICOPP) Group.
Daijo
D
Inaguma
Fujita Health University School of Medicine, Toyoake, Aichi, Japan.|The Aichi Cohort Study of Prognosis in Patients Newly Initiated Into Dialysis (AICOPP) Group.
Shigehisa
S
Koide
Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Kazuo
K
Takahashi
Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Hiroki
H
Hayashi
Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Midori
M
Hasegawa
Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Yukio
Y
Yuzawa
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy; D002423:Cause of Death; D005260:Female; D006339:Heart Rate; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects / Q000401:mortality*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
cardiovascular event; dialysis initiation; mortality; multicentre cohort study; resting heart rate