Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes.
Type 2 diabetes mellitus is a complex and heterogeneous disorder which in its most common manifestation arises from insulin resistance and later insulin insufficiency. Type 2 diabetes is characterised by impaired insulin sensitivity and diagnosed as hyperglycaemia. Because of its cardiovascular consequences, Type 2 diabetes represents one of the world's leading causes of mortality and morbidity. Drug discovery and development are required to produce better ways to prevent, treat and manage diabetes and its complications. Diabetes is a human, not an animal disease, so animals do not get Type 2 diabetes. However there are animal models which are variously suitable for the investigation of new agents for the treatment of Type 2 diabetes. In this Review we have examined the various models that are available for the study of natural products with a focus on models (genetic, nutritional and spontaneous) for the metabolic abnormities of diabetes. These models are also relevant to the investigation of Western medicines for the treatment of diabetes. A suitable experimental model plays an important role in drug discovery for translational studies leading to increased understanding of the molecular basis and management of diabetes.
Asian Network of Research on Antidiabetic Plants (ANRAP), Bangladesh University of Health Science, Mirpur, Dhaka 1216, Bangladesh.
Md
M
Asrafuzzaman
Department of Pharmacy, Xinhua College of Sun Yat-sen University,Tianhe District, Guangzhou 510520, China.
Yingnan
Y
Cao
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland 4102 Australia.
Rizwana
R
Afroz
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland 4102 Australia.
Danielle
D
Kamato
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland 4102 Australia.
Susan
S
Gray
Department of Pharmacy, Xinhua College of Sun Yat-sen University,Tianhe District, Guangzhou 510520, China; School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland 4102 Australia. Electronic address: p.little@uq.edu.au.
Peter J
PJ
Little
D000818:Animals; D001688:Biological Products / Q000494:pharmacology* / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D007333:Insulin Resistance / Q000502:physiology; D023421:Models, Animal
D001688:Biological Products; D007004:Hypoglycemic Agents
Animal models; Genetics; Hyperglycaemia; Streptozotocin,