Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney With Sarcomatoid Dedifferentiation.
Mucinous tubular and spindle cell carcinoma (MTSCC) is a recent entity introduced in the World Health Organization 2004 Classification. It is a tumour of low malignant potential. MTSCC is a subtype of renal cell carcinoma (RCC), which is characterized by a polymorphous histology, wherein the spindled epithelial cell is an inherent carcinomatous component. We report the case of a 57-year-old man presenting with loin pain and dragging sensation. Imaging revealed a large mass arising from the left kidney. Radical nephrectomy was performed, and histopathology revealed spindle cell elements of MTSCC with low-grade cytology, which occasionally blended with tubular structures in variable mucinous stroma admixed with spindle sarcomatoid cells with marked nuclear pleomorphism, associated with significant necrosis and mitoses of up to 5/10 high-power field. A final diagnosis of MTSCC along with high-grade areas consistent with sarcomatoid dedifferentiation was made. Sarcomatoid dedifferentiation has been well documented in various subtypes of RCC, and its presence signifies a worse prognosis in RCC.
Department of Pathology, and Department of Radiotherapy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, UP, India.
Kafil
K
Akhtar
Department of Pathology, and Department of Radiotherapy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, UP, India.
Pragati
P
Agnihotri
Department of Pathology, and Department of Radiotherapy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, UP, India.
Kiran
K
Alam
Department of Pathology, and Department of Radiotherapy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, UP, India.
Kashif
K
Raza
immunohistochemistry; kidney; mucinous; sarcomatoid dedifferentiation; spindle cell carcinoma