From snapshots to movies: Understanding early tooth development in four dimensions.
The developing tooth offers a model for the study of ectodermal appendage organogenesis. The signaling networks that regulate tooth development have been intensively investigated, but how cell biological responses to signaling pathways regulate dental morphogenesis remains an open question. The increasing use of ex vivo imaging techniques has enabled live tracking of cell behaviors over time in high resolution. While recent studies using these techniques have improved our understanding of tooth morphogenesis, important gaps remain that require additional investigation. In addition, some discrepancies have arisen between recent studies, and resolving these will advance our knowledge of tooth development. Developmental Dynamics 246:442-450, 2016. © 2017 Wiley Periodicals, Inc.
Program in Craniofacial Biology and Department of Orofacial Sciences, University of California San Francisco, San Francisco, California.
Rebecca
0000-0001-8309-9891
R
Kim
Department of Craniofacial Development & Stem Cell Biology, King's College London, London, United Kingdom.
Jeremy B A
JBA
Green
Program in Craniofacial Biology and Department of Orofacial Sciences, University of California San Francisco, San Francisco, California.|Institute for Human Genetics, University of California San Francisco, San Francisco, California.|Department of Pediatrics, University of California San Francisco, San Francisco, California.
Ophir D
OD
Klein
D006801:Humans; D021621:Imaging, Three-Dimensional; D009024:Morphogenesis; D009805:Odontogenesis; D015398:Signal Transduction; D014070:Tooth / Q000254:growth & development*
cell behavior; epithelial dynamics; molecular signaling; morphogenesis; tooth development