EFFECTS AND MECHANISMS OF A NEW MULTIVITAMIN ON CHRONIC METABOLIC SYNDROMES AND AGING.
BACKGROUND
Increased occurrence of chronic syndromes has prompted researchers to investigate and develop drugs and methods for controlling chronic syndromes with a view to improve human health and reduce early aging.


METHODS
Human trials: After the allotted multivitamin pills or placebo pills had been taken for a stipulated period of about 2 months, the volunteers filled out feedback forms on curative effects of the pills in line with the health examination reports. The effects of the multivitamin on various symptoms or diseases and dysfunctions of the chronic metabolic syndromes were noted and evaluated based on the information provided in forms. Animal experiments: Mouse aging model induced by D-galactose were administered the multivitamin by oral gavage every morning. At the end of the sixth week, activity or content of the components associated with ageing and anti-aging in the brain and liver of the aging mice were determined to investigate the mechanisms of the new multivitamin on chronic metabolic syndromes and aging.


RESULTS
We found that multivitamin can eliminate or attenuate 38 types of symptoms or dysfunctions of the investigated metabolic syndromes; and that it has both preventive and curative/adjunctive therapeutic effects on the metabolic syndromes. The effects of this multivitamin on components associated with aging and anti-aging were significantly decreased - malondialdehyde content and monoamine oxidase activity but significantly increased activity of superoxide dismutase and glutathione peroxidase. This multivitamin has significant anti-aging effects.


CONCLUSIONS
Supplementing with this multivitamin can prevent and provide treatment/adjunctive therapy for these chronic metabolic syndromes and delay the aging process. List of AbbreviationsBWbody weight; Cu/Zn-SOD, cuprum/zinc-superoxide dismutaseMAOmonoamine oxidaseMDAmalondialdehyde; Mn-SOD, manganese-superoxide dismutase; T-SOD, total superoxide dismutase; TP, total protein.
School of Chemistry and Bioengineering, Changsha University of Science and Technology, Changsha 410004, China.
Su-Xi
SX
Wu
School of Chemistry and Bioengineering, Changsha University of Science and Technology, Changsha 410004, China.
Xuewei
X
Jiang
Department of Health Care, People's Hospital of Hunan Province, Changsha 410004, China.
Yu-Ying
YY
Liu
Hospital of Changsha University of Science and Technology, Changsha 410004, China.
Lin-Feng
LF
Chen
School of Chemistry and Bioengineering, Changsha University of Science and Technology, Changsha 410004, China.
Jun
J
Tao
D000328:Adult; D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D019587:Dietary Supplements / Q000032:analysis; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000378:metabolism; D014815:Vitamins / Q000008:administration & dosage*
D000975:Antioxidants; D014815:Vitamins; D008315:Malondialdehyde; D013482:Superoxide Dismutase
Aging; Anti-aging; Mechanism; Metabolic syndrome; Multivitamin