Trismus following different treatment modalities for head and neck cancer: a systematic review of subjective measures.
The aim of this review was to compare systematically the subjective measure of trismus between different interventions to treat head and neck cancer, particularly those of the oropharynx. Using The Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) Guidelines, Six databases were searched for the text using various terms which include "oropharyngeal/head and neck cancer", "trismus/mouth opening" and the various treatment modalities. Included in the review were clinical studies (> or =10 patients). Three observers independently assessed the papers identified. Among the six studies reviewed, five showed a significantly worst outcome with regard to the quality-of-life questionnaire scores for a radiotherapy or surgery and radiotherapy (RT) ± chemotherapy or chemoradiotherapy when compared to surgery alone. Only one study showed no significant difference between surgery alone and other treatment modalities. Subjective quality-of-life measures are a concurrent part of modern surgical practice. Although subjective measures were utilised to measure post operative trismus successfully, there was no consensus as to which treatment modality had overall better outcomes, with conflicting studies in keeping with the current debate in this field. Larger and higher quality studies are needed to compare all three treatment modalities.
Cardiff University School of Medicine, Cardiff, UK. LohSY@cardiff.ac.uk.
Sook Y
SY
Loh
Department of Otolaryngology, University Hospital of Wales, Cardiff, UK.
Robert W J
RWJ
Mcleod
Department of Otolaryngology, University Hospital of Wales, Cardiff, UK.
Hassan A
HA
Elhassan
D016208:Databases, Factual; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D011183:Postoperative Complications; D036301:Qualitative Research; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014313:Trismus / Q000209:etiology*
Chemotherapy; Oropharyngeal carcinoma; Quality of life; Radiotherapy; Surgery; Trismus