Mycoplasma hominis, Ureaplasma urealyticum and Chlamydia trachomatis Respiratory Colonization in Malaysian Preterm Infants.
This prospective observational study aims to determine the incidence, predictors and clinical features of Mycoplasma hominis (MH), Ureaplasma urealyticum (UU) and Chlamydia trachomatis (CT) respiratory colonization in infants <37 weeks of gestation. A total of 200 preterm newborns admitted to a tertiary center in Malaysia between 2013 and 2015 for increased breathing effort had their respiratory secretions tested for these bacteria by polymerase chain reaction. Fifteen of the 200 (7.5%) infants were detected to have these organisms in their respiratory tracts. Preterm prelabor rupture of membrane was associated with positive detection (odds ratio: 3.7; 95% confidence interval: 1.2-11.3). Seventy-three of the 200 (36.5%) infants were given macrolide for presumed infection but only 4.1% (3 of 73) were positive for these organisms. The incidence of UU respiratory colonization among preterm infants in our center is lower than other published reports, while the frequency of MH and CT isolation is comparable with many studies. There should be judicious use of empirical antibiotics for presumed UU, MH and CT infection in preterm infants.
Paediatric Infectious Diseases and Immunology, Great North Children's Hospital, NE1 4LP England; Department of Paediatrics, Tuanku Jaafar Hospital, 70300 Seremban, Malaysia.
Khuen Foong
KF
Ng
Department of Paediatrics, Tuanku Jaafar Hospital, 70300 Seremban, Malaysia.
Kah
K
Kee Tan
Department of Paediatrics, Tuanku Jaafar Hospital, 70300 Seremban, Malaysia.
Mi-Chelle
MC
Chok
Department of Paediatrics, Tuanku Jaafar Hospital, 70300 Seremban, Malaysia.
Nurul
N
Zamil Mohd Muzzamil
Department of Paediatrics, Tuanku Jaafar Hospital, 70300 Seremban, Malaysia.
Pauline
P
Choo
Department of Paediatrics, Tuanku Jaafar Hospital, 70300 Seremban, Malaysia.
Umathevi
U
Paramasivam
Department of Microbiology, Tuanku Jaafar Hospital, 70300 Seremban, Malaysia.
Marlindawati
M
Mohd Ali
Department of Paediatrics, Sabah Women's and Children's Hospital, 88996 Kota Kinabalu, Malaysia.
Jun
J
Yan Goh
Department of Nutrition and Dietetics, Universiti Putra Malaysia, 43400 Serdang, Malaysia.
Wan
W
Ying Gan