Rationale and design of a multicenter, international and collaborative Coronary Artery Aneurysm Registry (CAAR).
Coronary artery aneurysm is defined as a coronary dilation that exceeds the diameter of adjacent segments or the diameter of the patient's largest normal coronary vessel by 1.5×. It is an uncommon disease that has been diagnosed with increasing frequency since the widespread appearance of coronary angiography. The published incidence varies from 1.5% to 5%, suggesting male dominance and a predilection for the right coronary artery. Although several causes have been described, atherosclerosis accounts for ≥50% of coronary aneurysms in adults. Reported complications include thrombosis and distal embolization, rupture, and vasospasm, causing ischemia, heart failure, or arrhythmias. The natural history and prognosis remain unknown, as definitive data are scarce. Controversies persist regarding the use of medical management (antithrombotic therapy) or interventional/surgical procedures. Only some case reports or small case series are available about this condition. The Coronary Artery Aneurysm Registry (CAAR; http://www.ClinicalTrials.gov NCT02563626) is a multicenter international ambispective registry that aims to provide insights on anatomic, epidemiologic, and clinical aspects of this substantially unknown entity. In addition, the registry will assess management strategies (conservative, interventional, or surgical) and their short- and long-term results in a large cohort of patients.


BACKGROUND
ClinicalTrials.gov. Unique identifier: NCT02563626.
Cardiovascular Institute, Hospital Clínico San Carlos and Department of Medicine, Complutense University, Madrid, Spain.
Iván J
IJ
Núñez-Gil
Cardiovascular Institute, Hospital Clínico San Carlos and Department of Medicine, Complutense University, Madrid, Spain.
Luis
L
Nombela-Franco
Division of Cardiology, Department of Medicine, London Health Sciences Centre, and Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Rodrigo
R
Bagur
Department of Interventional Cardiology, SS Annanziata Hospital, Savigliano, Italy.
Mario
M
Bollati
Interventional Unit, San Luigi Gonzaga University Hospital, Orbassano and Infermi HOspital, Rivoli (Turin), Italy.
Enrico
E
Cerrato
Instituto de Cardiología y Cirugía Cardiovascular, La Habana, Cuba.
Emilio
E
Alfonso
Department of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site Rhein-Main, Frankfurt am Main, Germany.
Christoph
C
Liebetrau
Department of Cardiology, Hospital de Valdecilla, Santander, Spain.
José María
JM
De la Torre Hernandez
Department of Interventional Cardiology, Hospital Arnau de Vilanova, Lérida, Spain.
Benjamín
B
Camacho
Department of Cardiology, Hospital de Clínicas Dr. Manuel Quintela, Montevideo, Uruguay.
Rafael
R
Mila
Department of Interventional Cardiology, Hospital Clínico Universitario de Valladolid, Spain.
Ignacio J
IJ
Amat-Santos
Department of Cardiology, Hospital Universitario de La Princesa, Madrid, Spain.
Fernando
F
Alfonso
Department of Interventional Cardiology, University Medical Center Utrecht, The Netherlands.
Ramón
R
Rodríguez-Olivares
Department of Interventional Cardiology, Hospital Juan Ramón Jiménez, Huelva, Spain.
Santiago J
SJ
Camacho Freire
Department of Interventional Cardiology, Hospital de Cabueñes, Gijon, Spain.
Íñigo
Í
Lozano
Department of Interventional Cardiology, Hospital Álvaro Cunqueiro, Vigo, Spain.
Víctor Alfonso
VA
Jiménez Díaz
UO di Cardiologia Interventistica ed Hemodinámica, Azienda Ospedaliera Universitaria Policlinico "P. Giaccone,", Palermo, Italy.
Davide
D
Piraino
Department of Cardiology, Ospedale Fatebenefratelli, Milan, Italy.
Roberto Adriano
RA
Latini
Cardiovascular Institute, Hospital Clínico San Carlos and Department of Medicine, Complutense University, Madrid, Spain.
Gisela
G
Feltes
Department of Interventional Cardiology, Hospital Lozano Blesa, Zaragoza, Spain.
Jose Antonio
JA
Linares
Department of Interventional Cardiology, Hospital La Sapienza, Rome, Italy.
Massimo
M
Mancone
Cardiology Division, Bolognini Hospital Seriate, Italy.
Alfonso
A
Ielasi
Hospital Universitario de Canarias, San Cristobal de la Laguna, Spain.
Alejandro
A
Sánchez-Grande Flecha
Department of Interventional Cardiology, Hospital Bellvitge, Barcelona, Spain.
Agustín
A
Fernández Cisnal
Department of Interventional Cardiology, Hospital San Giovanni Bosco, Turin, Italy.
Fabrizio
F
Ugo
Interventional Cardiology, Hospital General Universitario de Albacete, Spain.
Jesús M
JM
Jiménez Mazuecos
Department of Cardiology, Città della Salute e della Scienza I, Turin, Italy.
Pierluigi
P
Omedè
Department of Cardiology, Città della Salute e della Scienza II, Turin, Italy.
Marco
M
Pavani
Department of Interventional Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, New York City, New York.
Pedro A
PA
Villablanca
Division of Cardiovascular Diseases, Mayo Clinic, Phoenix, Arizona.
Boshra F
BF
Louka
Cardiovascular Institute, Hospital Clínico San Carlos and Department of Medicine, Complutense University, Madrid, Spain.
Antonio
A
Fernández-Ortiz
D003299:Cooperative Behavior; D003323:Coronary Aneurysm / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000628:therapy; D017023:Coronary Angiography; D003462:Cuba; D005060:Europe; D006801:Humans; D007391:International Cooperation; D011237:Predictive Value of Tests; D011379:Prognosis; D012042:Registries; D012107:Research Design; D012307:Risk Factors; D013997:Time Factors; D014481:United States; D014583:Uruguay

CAAR
; Coronary Aneurysm; Epidemiology; Prognosis; Registry