Infantile Tremor Syndrome and Subdural Hemorrhage in an Infant with Cystic Fibrosis.
Cystic fibrosis (CF), an autosomal recessive disease with multi-system involvement, may present with bleeding in infancy owing to vitamin K malabsorption. Infantile tremor syndrome (ITS) is an obscure condition associated with vitamin B12 and other micronutrient deficiencies, described predominantly in Indian subcontinent. We describe an infant presenting with ITS and chronic subdural hemorrhage. He was subsequently diagnosed to have CF. The ITS and subdural hemorrhage is rarely reported in children with CF. In the background of increasing recognition of CF in Indian children, this case demonstrates a new association of this disease.
Department of Pediatrics, Sitaram Bhartia Institute of Science and Research, New Delhi 110016, India.
Anirban
A
Mandal
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India.
Mayank
M
Priyadarshi
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India.
Kanaram
K
Jat
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India.
Sushil Kumar
SK
Kabra
D001780:Blood Coagulation Tests; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000209:etiology; D006474:Hemorrhagic Disorders / Q000209:etiology*; D006801:Humans; D007223:Infant; D007228:Infant Nutrition Disorders / Q000209:etiology; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008286:Malabsorption Syndromes / Q000150:complications*; D013577:Syndrome; D014202:Tremor / Q000209:etiology*; D014813:Vitamin K Deficiency / Q000150:complications*
cystic fibrosis; infantile tremor syndrome; subdural hemorrhage