Adiposity in childhood brain tumors: A report from the Canadian Study of Determinants of Endometabolic Health in Children (CanDECIDE Study).
Children with brain tumors (CBT) are at high risk of cardiovascular diseases and type 2 diabetes compared to the general population. Recently, adiposity has been reported to be more informative for cardiometabolic risk stratification than body mass index (BMI) in the general population. The goal of this study is to describe the adiposity phenotype in CBT, and to establish adiposity determinants. We recruited CBT (n = 56) and non-cancer controls (n = 106). Percent body fat (%FM), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were measured to determine total and central adiposity, respectively. Regression analyses were used to evaluate adiposity determinants. CBT had higher total and central adiposity compared to non-cancer controls despite having similar BMI measurements. Those with tumors at the supratentorial region had increased total and central adiposity, while those who received radiotherapy had increased total adiposity. In conclusion, CBT have increased total and central adiposity in the presence of similar BMI levels when compared to non-cancer controls. Adiposity, especially central adiposity, is a potential cardiometabolic risk factor present relatively early in life in CBT. Defining interventions to target adiposity may improve long-term outcomes by preventing cardiometabolic disorders in CBT.
Medical Sciences Program, McMaster University, Hamilton, Ontario, Canada.|Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.|Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada.
Kuan-Wen
KW
Wang
Medical Sciences Program, McMaster University, Hamilton, Ontario, Canada.|Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Russell J de
RJ
Souza
Medical Sciences Program, McMaster University, Hamilton, Ontario, Canada.|Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.|Division of Pediatric Hematology/Oncology, McMaster Children's Hospital, Hamilton, Ontario, Canada.
Adam
A
Fleming
Division of Neurosurgery, Department of Surgery, McMaster Children's Hospital, Hamilton, Ontario, Canada.|McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada.
Sheila K
SK
Singh
Division of Pediatric Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Donna L
DL
Johnston
Pediatric Hematology Oncology, London Health Sciences Center, London, Ontario, Canada.
Shayna M
SM
Zelcer
Division of Pediatric Hematology/Oncology/BMT, Department of Pediatrics, British Columbia Children's Hospital, Vancouver, BC, Canada.
Shahrad Rod
SR
Rassekh
Division of Orthopedic Surgery, Department of Surgery, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Sarah
S
Burrow
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.|Division of Hematology/Oncology, University Children's Hospital, Basel, Switzerland.
Katrin
K
Scheinemann
Medical Sciences Program, McMaster University, Hamilton, Ontario, Canada.|Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.|Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.|Centre for Evaluation of Medicines, St. Joseph's Health Care, Hamilton, ON, Canada.|Biostatistics Unit, St. Joseph's Healthcare-Hamilton, Ontario, Canada.
Lehana
L
Thabane
Medical Sciences Program, McMaster University, Hamilton, Ontario, Canada.|Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.|Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada.|Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
M Constantine
MC
Samaan
D050154:Adiposity; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000209:etiology* / Q000532:radiotherapy / Q000628:therapy; D002170:Canada / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015444:Exercise; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D009765:Obesity / Q000150:complications*; D055815:Young Adult