Late onset MELAS with m.3243A > G mutation and its association with aneurysm formation.
We reported a 53-year-old with late-onset mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) accompanied by aneurysm and large vessel dilations. Most studies have focused on microangiopathy causing stroke-like episodes. We report a case to describe large vessel involvement in clinical considerations, and possible mechanisms of aneurysm formation. We recommended regular angiographic examination for patients with MELAS.
Department of Neurology, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, China.|The 96th Class, 7-Year Program, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, China.
Kun
K
Zhu
Department of Neurology, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, China.
Shuang
S
Li
Department of Neurology, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, China.
Huan
H
Chen
Department of Neurology, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, China.
Yao
Y
Wang
Department of Neurology, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, China.|The 97th Class, 7-Year Program, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, China.
Miao
M
Yu
Department of Cadre, The Central Hospital of Jiamusi City, No. 256 Zhongshan Road, Xiangyang District, Jiamusi, Heilongjiang, 154002, China.
Hongyan
H
Wang
Department of Neurology, Capital Medical University Affiliated Beijing Friendship Hospital, No. 95 Yongan Road, Xicheng District, Beijing, 100050, China.
Weijie
W
Zhao
Department of Neurology, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, China. ypengcao@yahoo.com.
Yunpeng
Y
Cao
D000783:Aneurysm / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D004272:DNA, Mitochondrial / Q000235:genetics; D006801:Humans; D017241:MELAS Syndrome / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012356:RNA, Transfer, Leu / Q000235:genetics*
D004272:DNA, Mitochondrial; C000625432:MT-TL1 tRNA, human; D012356:RNA, Transfer, Leu
Aneurysm; Apoptosis; MELAS; Nitric oxide synthase