Resuscitation-promoting factors are important determinants of the pathophysiology in Mycobacterium tuberculosis infection.
Resuscitation promoting factors (Rpf) are peptidoglycan-hydrolyzing enzymes that are pivotal in the resuscitation of quiescent actinobacteria including Mycobacterium tuberculosis. From the published data, it is clear that Rpf are required for the resuscitation of non-replicating bacilli and pathogenesis in murine infection model of tuberculosis, although their direct influence on human Mycobacterium tuberculosis infection is ill-defined. In this review, we describe the progress in the understanding of the roles that Rpf play in human tuberculosis pathogenesis and importance of bacilli dependent upon Rpf for growth for the outcome of human tuberculosis. We outline how this research is opening up important opportunities for the diagnosis, treatment and prevention of human disease, progress in which is essential to attain the ultimate goal of tuberculosis eradication.
a Department of Infection, Immunity and Inflammation , University of Leicester , Leicester , UK.|b Department of Infection and Tropical Medicine , University Hospitals of Leicester NHS Trust , Leicester , UK.
Andrew
A
Rosser
a Department of Infection, Immunity and Inflammation , University of Leicester , Leicester , UK.
Cordula
C
Stover
a Department of Infection, Immunity and Inflammation , University of Leicester , Leicester , UK.|b Department of Infection and Tropical Medicine , University Hospitals of Leicester NHS Trust , Leicester , UK.
Manish
M
Pareek
a Department of Infection, Immunity and Inflammation , University of Leicester , Leicester , UK.
Galina V
GV
Mukamolova
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000276:immunology* / Q000502:physiology*; D010457:Peptidoglycan / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; D015415:Biomarkers; D016207:Cytokines; D010457:Peptidoglycan; D037521:Virulence Factors; C113704:resuscitation-promoting factor, bacteria
Mycobacterium tuberculosis; Resuscitation promoting factors; Rpf; pathogenesis; tuberculosis