Metabolic Disorder in Chronic Obstructive Pulmonary Disease (COPD) Patients: Towards a Personalized Approach Using Marine Drug Derivatives.
Metabolic disorder has been frequently observed in chronic obstructive pulmonary disease (COPD) patients. However, the exact correlation between obesity, which is a complex metabolic disorder, and COPD remains controversial. The current study summarizes a variety of drugs from marine sources that have anti-obesity effects and proposed potential mechanisms by which lung function can be modulated with the anti-obesity activity. Considering the similar mechanism, such as inflammation, shared between obesity and COPD, the study suggests that marine derivatives that act on the adipose tissues to reduce inflammation may provide beneficial therapeutic effects in COPD subjects with high body mass index (BMI).
Clinical and Molecular Epidemiology, IRCSS San Raffaele Pisana, Via di Valcannuta 247, I-00166 Rome, Italy. palma.lamonica@sanraffaele.it.
Palma
P
Lamonaca
Clinical and Molecular Epidemiology, IRCSS San Raffaele Pisana, Via di Valcannuta 247, I-00166 Rome, Italy. giulia.prinzi@sanraffaele.it.
Giulia
G
Prinzi
Clinical and Molecular Epidemiology, IRCSS San Raffaele Pisana, Via di Valcannuta 247, I-00166 Rome, Italy. alesseus@gmail.com.
Aliaksei
A
Kisialiou
Department of Pulmonary Rehabilitation, IRCCS San Raffaele Pisana, Via della Pisana 235, I-00163 Rome, Italy. vittorio.cardaci@sanraffaele.it.
Vittorio
V
Cardaci
Scientific Direction, IRCSS San Raffaele Pisana, Via di Valcannuta 247, I-00166 Rome, Italy. massimo.fini@sanraffaele.it.
Massimo
M
Fini
Clinical and Molecular Epidemiology, IRCSS San Raffaele Pisana, Via di Valcannuta 247, I-00166 Rome, Italy. patrizia_russo@hotmail.com.
Patrizia
P
Russo
D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry*; D001685:Biological Factors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008659:Metabolic Diseases / Q000188:drug therapy*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*
D001685:Biological Factors
chronic obstructive pulmonary disease; comorbidities; inflammation; management strategy; marine compound; metabolic disorder; systems approaches