The Relationship between Adiponectin and Breast Cancer.
OBJECTIVE
Breast cancer is the most common type of cancer in women worldwide. It is indicated that increased body mass index elevates the risk of developing breast cancer, worsens prognosis, and decreases survival. Several polymorphisms of adiponectin have been shown to affect serum levels of adiponectin and their association with breast cancer. The aim of this study was to investigate the relationship between the adiponectin 45T/G and 276 G/T gene polymorphism and breast cancer in the East Marmara region.


METHODS
A case-control study was performed in 97 patients with breast cancer and 101 controls in East Marmara in order to evaluate the prevalence of adiponectin gene polymorphism at positions 45 and 276. Patients with familial breast cancer and those who had received chemotherapy or radiotherapy were excluded from the study. Adiponectin gene polymorphisms were investigated using polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP).


RESULTS
Adiponectin 45T/G gene genotype frequencies of TT, TG, and GG were 61.9%, 37.1%, and 1% in patients with breast cancer, and 67.3%, 30.7%, and 2% in the control group, respectively. Adiponectin 276G/T gene genotype frequencies of GG, GT, and TT were 45.4%, 45.4%, and 9.3% in patients with breast cancer and 55.4%, 39.6%, and 5.0% in the control group, respectively.


CONCLUSIONS
Our study showed that adiponectin 45T/G and 276 G/T gene polymorphism is not associated with breast cancer risk in patients from the East Marmara region.
Clinic of General Surgery, Mustafa Kalemli Tavşanlı State Hospital, Kütahya, Turkey.
Burcu
B
Erbay
Department of General Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey.
Tonguç Utku
TU
Yılmaz
Department of Biochemistry, Kocaeli University School of Medicine, Kocaeli, Turkey.
Ceyla
C
Eraldemir
Department of Medical Biology, Kocaeli University School of Medicine, Kocaeli, Turkey.
Nihal
N
Üren
Clinic of General Surgery, Derince Training and Research Hospital, Kocaeli, Turkey.
Çağrı
Ç
Tiryaki
Department of Medical Biology, Kocaeli University School of Medicine, Kocaeli, Turkey.
Emel
E
Ergül
Department of General Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey.
Zafer
Z
Utkan
Breast cancer; adiponectin; genetic polymorphism