Solitary plasmacytoma associated with Epstein-Barr virus: a clinicopathologic, cytogenetic study and literature review.
Solitary plasmacytoma (SP) is an uncommon, indolent tumor of plasma cell neoplasms that presents as a mass lesion in extramedullary sites. Evidence of Epstein-Barr virus (EBV) infection is frequently associated with various lymphatic and hematopoietic malignancies but is relatively rare in SP. Moreover, it is essential to distinguish EBV-positive plasmacytoma from plasmablastic lymphoma. In this study, we found 4 EBV-encoded RNA (EBER)-positive patients among 46 consecutive immunocompetent patients of SP and compared the clinicopathologic features of these patients with those of the EBER-negative cohort. In the 4 EBER-positive patients, the common presenting feature was a local mass lesion without symptoms of chronic active EBV infection. Upon histologic examination, neoplastic cells demonstrated well-differentiated morphology in the absence of plasmablastic lymphoma components. Fluorescence in situ hybridization analysis showed that all cases were negative for del13q14, t(11;14)(q13;32) and MYC rearrangement but that 1 case had cytogenetic aberrations involving del17p13. Follow-up data revealed that EBER-positive patients had benign prognoses without aggressive clinical course and that there was no significant difference in the overall survival time between the 2 groups, but EBER-positive patients were more likely to have disease progression (relapse/progression to multiple myeloma) compared with EBER-negative patients. More case studies are needed to better understand the impact of EBV on disease pathogenesis and development in immunocompetent patients of SP.
Department of Pathology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China.
Jiaqi
J
Yan
Department of Pathology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China.
Jianchao
J
Wang
Department of Pathology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China.
Wenyan
W
Zhang
Department of Pathology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China.
Min
M
Chen
Department of Pathology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China.
Jie
J
Chen
Department of Pathology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China. Electronic address: liuweiping2001@vip.sina.com.
Weiping
W
Liu
D000328:Adult; D000368:Aged; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000473:pathology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D009364:Neoplasm Recurrence, Local / Q000150:complications; D010954:Plasmacytoma / Q000175:diagnosis / Q000473:pathology* / Q000821:virology
Cytogenetic analysis; Epstein-Barr virus; Solitary plasmacytoma