Clinical Course and Outcomes of Pediatric Tubercular Uveitis in North India.
OBJECTIVE
To analyze the clinical features, course, management, and outcomes of tubercular (TB) uveitis in the pediatric population and assess the response to anti-tubercular therapy (ATT).


METHODS
Hospital records of children (≤16 years) from a large tertiary-care institute between January 2001 and December 2015 were reviewed.


RESULTS
A total of 32 children (mean age: 10.7 ± 4.27 years; range 2-16) were diagnosed with TB-associated uveitis. The most common presentation was posterior uveitis (n = 14, 43.75%) and panuveitis (n = 14, 43.75%), followed by intermediate uveitis (n = 2, 6.25%) and anterior uveitis (n = 2, 6.25%); 14 children had probable intraocular tuberculosis (IOTB) (43.75%) and 17 (53.13%) had possible IOTB. Despite ATT and corticosteroids, 29.63% patients showed suboptimal response or worsening of disease requiring additional immunosuppression.


CONCLUSIONS
TB is an important cause of pediatric uveitis in endemic countries. The manifestations of the disease resemble adult TB-related uveitis. However, higher inflammatory response in children may require more aggressive therapy with corticosteroids/immunosuppression.
a Department of Ophthalmology, Advanced Eye Center , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Savleen
S
Kaur
a Department of Ophthalmology, Advanced Eye Center , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Kanika
K
Aggarwal
a Department of Ophthalmology, Advanced Eye Center , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Aniruddha
http://orcid.org/0000-0003-4985-9855
A
Agarwal
b Department of Pediatric Allergy Immunology Unit, Advanced Pediatric Center , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Deepti
D
Suri
b Department of Pediatric Allergy Immunology Unit, Advanced Pediatric Center , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Anju
A
Gupta
a Department of Ophthalmology, Advanced Eye Center , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Ramandeep
R
Singh
a Department of Ophthalmology, Advanced Eye Center , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Reema
R
Bansal
b Department of Pediatric Allergy Immunology Unit, Advanced Pediatric Center , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Surjit
S
Singh
a Department of Ophthalmology, Advanced Eye Center , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Nirbhai
N
Singh
a Department of Ophthalmology, Advanced Eye Center , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Amod
A
Gupta
a Department of Ophthalmology, Advanced Eye Center , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Vishali
V
Gupta
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D011379:Prognosis; D012189:Retrospective Studies; D014374:Tuberculin Test; D014392:Tuberculosis, Ocular / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D014605:Uveitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
D000305:Adrenal Cortex Hormones; D000995:Antitubercular Agents
Extrapulmonary tuberculosis; intraocular tuberculosis; pediatric tuberculosis; pediatric uveitis