A local adjustment strategy for the initialization of dynamic causal modelling to infer effective connectivity in brain epileptic structures.
This paper addresses the question of effective connectivity in the human cerebral cortex in the context of epilepsy. Among model based approaches to infer brain connectivity, spectral Dynamic Causal Modelling is a conventional technique for which we propose an alternative to estimate cross spectral density. The proposed strategy we investigated tackles the sub-estimation of the free energy using the well-known variational Expectation-Maximization algorithm highly sensitive to the initialization of the parameters vector by a permanent local adjustment of the initialization process. The performance of the proposed strategy in terms of effective connectivity identification is assessed using simulated data generated by a neuronal mass model (simulating unidirectional and bidirectional flows) and real epileptic intracerebral Electroencephalographic signals. Results show the efficiency of proposed approach compared to the conventional Dynamic Causal Modelling and the one wherein a deterministic annealing scheme is employed.
INSERM, U1099, Rennes 35000, France; Université de Rennes 1, LTSI, Rennes 35000, France; Centre de Recherche en Information Biomédicale sino-français (CRIBs), 35000, France.
Wentao
W
Xiang
INSERM, U1099, Rennes 35000, France; Université de Rennes 1, LTSI, Rennes 35000, France.
Ahmad
A
Karfoul
Laboratory of Image Science and Technology (LIST), School of Computer Science and Engineering, Southeast University, Nanjing 210096, China; Centre de Recherche en Information Biomédicale sino-français (CRIBs), 35000, France.
Huazhong
H
Shu
INSERM, U1099, Rennes 35000, France; Université de Rennes 1, LTSI, Rennes 35000, France; Centre de Recherche en Information Biomédicale sino-français (CRIBs), 35000, France. Electronic address: regine.le-bouquin-jeannes@univ-rennes1.fr.
Régine
R
Le Bouquin Jeannès
D000465:Algorithms; D001921:Brain / Q000503:physiopathology*; D003198:Computer Simulation; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted
Dynamic causal modelling; Effective connectivity; Epilepsy; Intracerebral EEG; Physiology based model