Characteristics of compatible pair participants in kidney paired donation at a single center.
Compatible pairs of living kidney donors and their intended recipients can enter into kidney paired donation (KPD) and facilitate additional living donor kidney transplants (LDKTs). We examined 11 compatible pairs (the intended recipients and their intended, compatible donors) who participated in KPD, along with the recipients' 11 matched, exchange donors. The 11 pairs participated in 10 separate exchanges (three were multicenter exchanges) that included 33 total LDKTs (22 additional LDKTs). All the intended donors were blood group O and female, with a mean living kidney donor profile index (LKDPI) of 27.6 (SD 16.8). The matched donors had a mean LKDPI of 9.4 (SD 31.7). Compatible pairs entered KPD for altruistic reasons (N=2) or due to mismatch of age (N=7) or body/kidney size (N=2) between the recipient and intended donor. In four cases, retrospective calculation of the LKDPI revealed that the matched donor had a higher LKDPI than the intended donor. Of the 22 recipients of LDKTs enabled by the compatible pairs, three were highly sensitized, with PRA >80%. In conclusion, most compatible pairs entered into KPD so that the recipient could receive a LDKT transplant from a donor whose age or body/kidney size were more favorable to post-transplant outcomes.
Renal & Pancreas Transplant Division, Saint Barnabas Medical Center, Livingston, NJ, USA.|Department of Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA.
Francis L
0000-0001-9780-4803
FL
Weng
Renal & Pancreas Transplant Division, Saint Barnabas Medical Center, Livingston, NJ, USA.
Tracy
T
Grogan
Renal & Pancreas Transplant Division, Saint Barnabas Medical Center, Livingston, NJ, USA.
Anup M
AM
Patel
Renal & Pancreas Transplant Division, Saint Barnabas Medical Center, Livingston, NJ, USA.
Shamkant
S
Mulgaonkar
Renal & Pancreas Transplant Division, Saint Barnabas Medical Center, Livingston, NJ, USA.
Marie M
MM
Morgievich
D000328:Adult; D000368:Aged; D046148:Donor Selection / Q000458:organization & administration*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006648:Histocompatibility; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D019520:Living Donors / Q000600:supply & distribution*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D009927:Tissue and Organ Procurement; D055815:Young Adult
blood group incompatibility; histocompatibility; kidney transplant; living donors; paired donation; patient selection