Polymorphisms of cancer stem cell marker gene CD133 are associated with susceptibility and prognosis of gastric cancer.
OBJECTIVE
This study was aimed to investigate the associations between single nucleotide polymorphisms of cancer stem cell marker genes, CD44 and CD133, and susceptibility and prognosis of gastric cancer.


METHODS
Five single nucleotide polymorphisms in CD44 and CD133 genes were genotyped in 898 gastric cancer cases and 992 controls.


RESULTS
The A/C or C/C genotypes of CD133 rs2240688 were associated with decreased risk of gastric cancer comparing with the A/A genotype (odds ratio: 0.81; 95% CI: 0.67-0.97; p = 0.023). The T allele of CD133 rs3130 predicted a worse survival for gastric cancer patients receiving tumorectomy (hazard ratio: 1.28; 95% CI: 1.04-1.58; p = 0.020), independent from tumor node metastasis stage, vessel invasion and postoperational chemotherapy.


CONCLUSIONS
CD133 polymorphisms are promising biomarkers for genetic susceptibility and prognosis prediction of gastric cancer.
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110112, PR China.|Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, PR China.
Zhi-Fang
ZF
Jia
Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, PR China.
Yan-Hua
YH
Wu
Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, PR China.
Dong-Hui
DH
Cao
Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun 130021, PR China.
Xue-Yuan
XY
Cao
Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, PR China.
Jing
J
Jiang
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110112, PR China.
Bao-Sen
BS
Zhou
D000071916:AC133 Antigen / Q000235:genetics*; D000368:Aged; D000483:Alleles; D014408:Biomarkers, Tumor; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality* / Q000628:therapy
D000071916:AC133 Antigen; D014408:Biomarkers, Tumor; D018960:Hyaluronan Receptors
CD133; CD44; gastric cancer; overall survival; polymorphism; susceptibility