Nanocrystalline cellulose-fullerene: Novel conjugates.
The covalent grafting of two amino-fullerene C60derivatives (C60-LC-NH2and C60-SC-NH2,LC=long chain and SC=short chain) onto the surface of TEMPO oxidized nanocrystalline cellulose (NCC-COOH) has been reported for the first time. These hybrids (NCC-LC-C60and NCC-SC-C60) form stable colloidal suspensions at concentrations up to 0.5mg/mL and act as effective photosensitizers for singlet oxygen production as demonstrated by the oxidation of L-methionine-methyl ester to the corresponding sulphoxide. Using the same approach, in a one-pot reaction both a fluorescent target molecule (FITC-LC-NH2) and the C60-LC-NH2derivative have been successfully attached covalently onto the NCC-COOH surface. These hybrids, which showed no cytotoxicity on MCF-7 human breast cancer cells could be good candidates in photodynamic cancer therapy.
Centre of Excellence for Nanostructured Materials (CENMAT), INSTM, Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa 1, 34127, Trieste, Italy. Electronic address: ana.herreroslopez@gmail.com.
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Herreros-López
Centre of Excellence for Nanostructured Materials (CENMAT), INSTM, Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa 1, 34127, Trieste, Italy. Electronic address: marco_carini@yahoo.it.
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Carini
Centre of Excellence for Nanostructured Materials (CENMAT), INSTM, Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa 1, 34127, Trieste, Italy. Electronic address: daros@units.it.
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Da Ros
Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy. Electronic address: tommaso.carofiglio@unipd.it.
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Carofiglio
Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy. Electronic address: carla.marega@unipd.it.
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Marega
Institute for the Nanostructured Materials Studies ISMN-CNR, Via La Malfa 153, 90146 Palermo, Italy. Electronic address: laparola@pa.ismn.cnr.it.
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La Parola
Department of Medical and Biological Sciences,, University of Udine, P.le Kolbe 4, 33100 Udine, Italy. Electronic address: valentina.rapozzi@uniud.it.
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Rapozzi
Department of Medical and Biological Sciences,, University of Udine, P.le Kolbe 4, 33100 Udine, Italy. Electronic address: luigi.xodo@uniud.it.
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Xodo
Department of Food and Nutrition, College of Food and Agriculture Science, King Saud University, P. O. Box 2460 Riyadh 11451, Saudi Arabia. Electronic address: alshatwi@ksu.edu.sa.
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Alshatwi
Centre of Excellence for Nanostructured Materials (CENMAT), INSTM, Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa 1, 34127, Trieste, Italy. Electronic address: chadad@units.it.
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Hadad
Centre of Excellence for Nanostructured Materials (CENMAT), INSTM, Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa 1, 34127, Trieste, Italy; CIC BiomaGUNE, Parque Tecnológico de San Sebastián, Paseo Miramón, 182, 20009 San Sebastián, Guipúzcoa, Spain; Basque Foundation for Science, Ikerbasque, Bilbao 48013, Spain. Electronic address: prato@units.it.
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Prato
Covalent functionalization; Fullerene C(60); Nanocrystalline cellulose; Photooxydation; Water-soluble derivatives