Recurrent bowel-blood translocations of Escherichia coli with the unique virulence characteristics over three-year period in the patient with acute myeloid leukaemia - case report.
In patients with haematological malignancies, the bowel remains the main source of Escherichia coli bloodstream infections. We present the clinical example of recurrent bowel-blood translocations of E. coli with the unique virulence characteristics in a 55-year-old male with the diagnosis of acute myeloid leukaemia. The virulent factors profile of examined strains confirmed that the co-existence of genes papC, sfa, usp and cnf1, encoding virulence factors, predisposes E. coli to translocation from the gastrointestinal tract to the vascular bed. The close cooperation between haematologists and microbiologists is essential to improve the outcome of patients colonised with highly pathogenic strains.
Department of Molecular Biotechnology and Microbiology, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland.
Beata
B
Krawczyk
Department of Therapy Monitoring and Pharmacogenetics, Medical University of Gdansk, Gdańsk, Poland.
Anna
A
Śledzińska
Department of Hematology and Transplantology, Medical University of Gdańsk, University Clinical Center, Dębinki 7, 80-952, Gdańsk, Poland. babajaga@gumed.edu.pl.
Agnieszka
http://orcid.org/0000-0002-1593-8005
A
Piekarska
Department of Hematology and Transplantology, Medical University of Gdańsk, University Clinical Center, Dębinki 7, 80-952, Gdańsk, Poland.
Andrzej
A
Hellmann
Department of Molecular Biotechnology and Microbiology, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland.
Józef
J
Kur
D018988:Bacterial Translocation; D004926:Escherichia coli / Q000235:genetics; D004927:Escherichia coli Infections / Q000097:blood*; D005798:Genes, Bacterial; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D015470:Leukemia, Myeloid, Acute / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics
D037521:Virulence Factors
Bacteraemia; Bowel translocation; Escherichia coli; Leukaemia; Virulence factors