The importance of the neutrophil-to-lymphocyte ratio in patients with hypertrophic cardiomyopathy.
BACKGROUND
Previous studies have demonstrated the predictive value of the neutrophil-to-lymphocyte ratio (NLR) in many cardiovascular disorders. The aim of this study was to assess whether NLR is associated with echocardiographic or electrocardiographic parameters, or with predicted five-year risk of sudden cardiac death (SCD), in patients with hypertrophic cardiomyopathy (HCM).


METHODS
This prospective observational study included 74 controls and 97 HCM patients. Three years of follow-up results for HCM patients were evaluated.


RESULTS
NLR was significantly higher in patients with fragmented QRS, ventricular tachycardia, and presyncope than in those without (p=0.031, 0.030, and 0.020, respectively). NLR was significantly higher in patients whose predicted five-year risk of SCD was more than 6% and whose corrected QT interval was greater than 440 ms (p=0.022 and 0.001, respectively). It was also significantly higher in patients whose left ventricular ejection fraction (LVEF) was <60% than in those with LVEF >60% (p=0.017).


CONCLUSIONS
NLR was significantly higher in patients with HCM compared to the control group. A high NLR is associated with a higher five-year risk of SCD in patients with HCM.
Biruni University, School of Medicine, Department of Cardiology, Istanbul, Turkey.
Sinem
S
Ozyilmaz
Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
Ozgur
O
Akgul
Bezmialem Vakıf University, School of Medicine, Department of Cardiology, Istanbul, Turkey.
Huseyin
H
Uyarel
Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
Hamdi
H
Pusuroglu
Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
Mehmet
M
Gul
Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
Muhammet Hulusi
MH
Satilmisoglu
Fethiye State Hospital, Department of Cardiology, Mugla, Turkey.
Ismail
I
Bolat
Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Pediatric Cardiology, Istanbul, Turkey. Electronic address: isaozyilmaz@gmail.com.
Isa
I
Ozyilmaz
Biruni University, School of Medicine, Department of Cardiology, Istanbul, Turkey.
Hakan
H
Uçar
Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
Aydin
A
Yildirim
Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiovascular Surgery, Istanbul, Turkey.
Ihsan
I
Bakir
D002312:Cardiomyopathy, Hypertrophic / Q000097:blood*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D011446:Prospective Studies; D018570:Risk Assessment
Five-year risk of sudden cardiac death; Hypertrophic cardiomyopathy; Miocardiopatia hipertrófica; Neutrophil-to-lymphocyte ratio; Relação neutrófilos/linfócitos; Score de risco a cinco anos de morte súbita cardíaca