The analysis of lncRNA HOTAIR rs12826786 C>T polymorphism and gastric cancer susceptibility in a Turkish population: lack of any association in a hospital-based case-control study.
BACKGROUND
The HOX transcript antisense intergenic RNA (HOTAIR), a well-known long noncoding RNA (lncRNA), has been widely identified to participate in pathogenesis of multiple cancers. An aberrant up-regulation and biological functions have been observed in gastric cancer (GC). A common single nucleotide polymorphism (SNP) (rs12826786 C>T) at the HOTAIR has been reported to influence HOTAIR expression, but its association with GC has yet to be investigated in Turkish population.


OBJECTIVE
The aim of the present study was to investigate whether HOTAIR rs12826786 C>T polymorphism could be involved in the risk of GC susceptibility in Turkish population.


METHODS
We genotyped HOTAIR rs12826786 C>T polymorphism in 312 Turkish individuals including 105 GC patients and 207 healthy controls matched on age and gender by a Real-Time Polymerase Chain Reaction (PCR) with the TaqMan assay.


RESULTS
No statistically significant differences were found in the allele or genotype distributions of the HOTAIR rs12826786 C>T polymorphism among GC and healthy control subjects (P > 0.05).


CONCLUSIONS
Our results demonstrate that the HOTAIR rs12826786 C>T polymorphism has not been in any major role in genetic susceptibility to gastric carcinogenesis, at least in the population studied here. Independent studies are needed to validate our findings in a larger series, as well as in patients of different ethnic origins.
Department of Gastroenterology, Education and Research Hospital, Adıyaman University, 02040, Adıyaman, Turkey.
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Y
Ülger
Faculty of Medicine, Department of Thoracic Surgery, Adıyaman University, 02040, Adıyaman, Turkey.
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E
Dadaş
Department of Gastroenterology, Isparta State Hospital, 32100, Isparta, Turkey.
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B
Yalinbaş Kaya
Faculty of Medicine, Department of Medical Oncology, Başkent University, 01250, Adana, Turkey.
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AT
Sümbül
Vocational School of Health Services, Adıyaman Univesity, 02040, Adıyaman, Turkey.
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A
Genç
Department of Nursing, Adıyaman School of Health, Adıyaman University, 02040, Adıyaman, Turkey. slymnbyrm81@gmail.com.
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Bayram
D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D014421:Turkey
C561566:HOTAIR long untranslated RNA, human; D062085:RNA, Long Noncoding
Gastric cancer; Genetic susceptibility; HOTAIR; HOTAIR rs12826786 C>T polymorphism; lncRNA