Facile Synthesis of a MoS2-Prussian Blue Nanocube Nanohybrid-Based Electrochemical Sensing Platform for Hydrogen Peroxide and Carcinoembryonic Antigen Detection.
Herein, an electrochemical detection platform was designed based on a Prussian blue nanocube-decorated molybdenum disulfide (MoS2-PBNCs) nanocomposite. Shape-controlled and high-dispersion PBNCs were supported on the MoS2nanosheet surface, which would be simply controlled by varying the experimental conditions. Expectedly, such obtained MoS2-based nanocomposites possessed excellent electrocatalytic ability, which could be employed to construct an electrochemical sensor for nonenzymatic hydrogen peroxide (H2O2) detection. More interestingly, MoS2-PBNCs nanocomposites could be utilized to construct a sensor for label-free detection of carcinoembryonic antigen (CEA). The electrochemical response of the MoS2-based immunosensor was linear with the CEA concentration ranging from 0.005 to 10 ng mL-1. Moreover, the detection limit was calculated to be 0.54 pg mL-1. The acceptable selectivity and high stability made such immunosensors detect CEA in human serum with satisfactory results. All data indicated that this MoS2-PBNCs nanocomposite may be a promising electrochemical sensing platform for the detection of chemical and biological molecules.
Shao
S
Su
Xiaoyan
X
Han
Zaiwei
Z
Lu
Wei
W
Liu
Dan
D
Zhu
Jie
J
Chao
Division of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences , Shanghai 201800, China.
Chunhai
http://orcid.org/0000-0002-7171-7338
C
Fan
Division of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences , Shanghai 201800, China.
Lihua
L
Wang
Division of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences , Shanghai 201800, China.
Shiping
http://orcid.org/0000-0002-0791-8012
S
Song
Lixing
L
Weng
Lianhui
http://orcid.org/0000-0001-9030-9172
L
Wang
D015374:Biosensing Techniques; D002272:Carcinoembryonic Antigen; D055664:Electrochemical Techniques; D005295:Ferrocyanides; D006801:Humans; D006861:Hydrogen Peroxide; D057230:Limit of Detection; D008982:Molybdenum / Q000737:chemistry*; D053761:Nanocomposites; D013440:Sulfides
D002272:Carcinoembryonic Antigen; D005295:Ferrocyanides; D013440:Sulfides; D008982:Molybdenum; D006861:Hydrogen Peroxide; C000170:ferric ferrocyanide
Molybdenum disulfide; Prussian blue nanocubes; electrochemical sensor; label-free; nonenzymatic