Recurrent podocytopathy in a patient with systemic lupus erythematosus.
Podocytopathy in systemic lupus erythematosus is characterised by diffuse foot process effacement without significant peripheral capillary wall immune deposits as seen on electron microscopy. Lupus podocytopathy falls outside the scope of the current International Society of Nephrology and the Renal Pathology Society classification of lupus nephritis. We present a case of relapsing podocytopathy with nephrotic syndrome occurring simultaneously with two extra-renal and serological disease flares, which makes it likely that podocytopathy was related to systemic lupus erythematosus activity. This case adds to the growing body of evidence that lupus podocytopathy must be considered in the differential diagnosis of systemic lupus erythematosus patients presenting with nephrotic syndrome.
Department of Rheumatology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Shereen
S
Paramalingam
Division of Anatomical Pathology, PathWest Laboratory Medicine, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Daniel D
DD
Wong
Department of Renal Medicine, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Gursharan K
GK
Dogra
Department of Rheumatology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia; School of Medicine and Pharmacology, The University of Western Australia, Perth, WA, Australia.
Johannes C
JC
Nossent
Systemic lupus erythematosus; nephrotic syndrome; podocytopathy