Rectorite-intercalated nanoparticles for improving controlled release of doxorubicin hydrochloride.
Controlled release of drugs has been widely researched in biomedical area. Nanoparticles (NPs) as ideal drug carriers are often used to facilitate improvements in the therapeutic index of drugs. In this study, natural polymers carboxymethyl chitosan (CMC) and lysozyme (LY) were mixed to prepare CMC-LY NPs by electrostatic self-assembly interactions. In addition, layered silicate rectorite (REC) was introduced into NPs to explore the effect on the encapsulation efficacy and controlled release of doxorubicin hydrochloride (DOX). It was confirmed that the average size of NPs increased with the addition of REC, and the interlayer distance of REC in NPs was enlarged because of the intercalation with polymer chains. Besides, the encapsulation efficiency and loading capacity of DOX in NPs increased markedly with the accretion of REC. The incorporation of REC into NPs could reduce the initial burst release and prolong the therapeutic time. Such results suggest that the REC-intercalated NPs are promising anticancer drug carriers for efficient cancer therapy.
Hubei-MOST KLOS & KLOBME, Department of Oral and Maxillofical Trauma and Plastic Surgery, Wuhan University Stomatological Hospital, Wuhan University, Wuhan 430079, China.
Jian
J
Jin
Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China.
Hu
H
Tu
Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China.
Jiajia
J
Chen
Hubei-MOST KLOS & KLOBME, Department of Oral and Maxillofical Trauma and Plastic Surgery, Wuhan University Stomatological Hospital, Wuhan University, Wuhan 430079, China.
Gu
G
Cheng
Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China.
Xiaowen
X
Shi
Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China. Electronic address: hbdeng@whu.edu.cn.
Hongbing
H
Deng
Hubei-MOST KLOS & KLOBME, Department of Oral and Maxillofical Trauma and Plastic Surgery, Wuhan University Stomatological Hospital, Wuhan University, Wuhan 430079, China. Electronic address: lizubing@sina.com.
Zubing
Z
Li
Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China.
Yumin
Y
Du
D000538:Aluminum Silicates / Q000737:chemistry*; D048271:Chitosan / Q000031:analogs & derivatives / Q000737:chemistry; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D008903:Minerals / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009113:Muramidase / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*
D000538:Aluminum Silicates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008903:Minerals; C514968:carboxymethyl-chitosan; C546376:rectorite; D004317:Doxorubicin; D048271:Chitosan; D009113:Muramidase
Chitosan; Controlled release; Lysozyme; Nanoparticles; Rectorite