Structural MRI and Amyloid PET Imaging for Prediction of Conversion to Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Meta-Analysis.
OBJECTIVE
The aim of this study was to explore the prognostic values of biomarkers of neurodegeneration as measured by magnetic resonance imaging (MRI) and amyloid burden as measured by amyloid positron emission tomography (PET) in predicting conversion to Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI).


METHODS
PubMed and EMBASE databases were searched for structural MRI or amyloid PET imaging studies published between January 2000 and July 2014 that reported conversion to AD in patients with MCI. Means and standard deviations or individual numbers of biomarkers with positive or negative status at baseline and corresponding numbers of patients who had progressed to AD at follow-up were retrieved from each study. The effect size of each biomarker was expressed as Hedges's g.


RESULTS
Twenty-four MRI studies and 8 amyloid PET imaging studies were retrieved. 674 of the 1741 participants (39%) developed AD. The effect size for predicting conversion to AD was 0.770 [95% confidence interval (CI) 0.607-0.934] for across MRI and 1.316 (95% CI 0.920-1.412) for amyloid PET imaging (p<0.001). The effect size was 1.256 (95% CI 0.902-1.609) for entorhinal cortex volume from MRI.


CONCLUSIONS
Our study suggests that volumetric MRI measurement may be useful for the early detection of AD.
Premedical Science, College of Medicine, Chosun University, Gwangju, Republic of Korea.; National Research Center for Dementia, Chosun University, Gwangju, Republic of Korea.
Eun Hyun
EH
Seo
National Research Center for Dementia, Chosun University, Gwangju, Republic of Korea.
Woon Yeong
WY
Park
National Research Center for Dementia, Chosun University, Gwangju, Republic of Korea.; Department of Neuropsychiatry, School of Medicine, Chosun University, Chosun University Hospital, Gwangju, Republic of Korea.
Il Han
IH
Choo
Alzheimer's disease; MRI; Meta-analysis; Mild cognitive impairment