Centrosomes: PIDDosome Joins the Counting Game.
Centrosome numbers are tightly regulated during the cell cycle. A new study shows that the PIDDosome prevents the propagation of cells carrying amplified centrosomes via p53 stabilisation and p21-mediated cell-cycle arrest, thus ensuring the maintenance of normal centrosome numbers.
Centre for Molecular Oncology, Barts Cancer Institute - a CRUK Centre of Excellence, Queen Mary, University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK. Electronic address: s.godinho@qmul.ac.uk.
Susana
S
Godinho
D002453:Cell Cycle; D059447:Cell Cycle Checkpoints; D018385:Centrosome; D016159:Tumor Suppressor Protein p53
D016159:Tumor Suppressor Protein p53