Self-Healable Supramolecular Hydrogel Formed by Nor-Seco-Cucurbit[10]uril as a Supramolecular Crosslinker.
A supramolecular hydrogel was formed by a simple mixing of solutions of nor-seco-cucurbit[10]uril (NS-CB[10]) and adamantylamine-terminated 4-armed polyethylene glycol (AdA-4-arm-PEG). In the formation of the hydrogel, NS-CB[10] acted as a noncovalent crosslinker to form a ternary complex with two AdA moieties. The dynamic and selective nature of the host-guest interaction between NS-CB[10] and AdA enabled the supramolecular hydrogel to rapidly recover its physical properties after it was damaged. In addition, the recovered hydrogel retained its physical properties with negligible differences from those of the pristine material, even after multiple self-healing cycles. The NS-CB[10]-based hydrogel with the self-healing property may be useful for various biological applications such as drug delivery, cell therapy and tissue engineering.
Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang, 37673, Republic of Korea.|Department of Nanomaterials and Engineering, University of Science and Technology (UST), Daejeon, 34113, Republic of Korea.
Kyeng Min
http://orcid.org/0000-0001-6089-6169
KM
Park
Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang, 37673, Republic of Korea.|Department of Biomolecular Science, University of Science and Technology (UST), Daejeon, 34113, Republic of Korea.
Joon Ho
JH
Roh
Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
Gihyun
G
Sung
Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang, 37673, Republic of Korea.
James
J
Murray
Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang, 37673, Republic of Korea.|Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.|Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
Kimoon
http://orcid.org/0000-0001-9418-3909
K
Kim
D001952:Bridged-Ring Compounds / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D001952:Bridged-Ring Compounds; D003432:Cross-Linking Reagents; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007093:Imidazoles; D046911:Macromolecular Substances; C507827:cucurbit(10)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
cucurbiturils; host-guest chemistry; hydrogels; self-healing; supramolecular chemistry