[High-irradiance accelerated corneal collagen crosslinking for the treatment of keratoconus: A retrospective study].
OBJECTIVE
To evaluate the safety and efficacy of accelerated corneal collagen crosslinking on stabilization of progressive keratoconus.


METHODS
This was a retrospective study from March 2013 to March 2015. Patients with progressive keratoconus who underwent accelerated corneal collagen crosslinking were included. Visual acuity with and without correction, biomicroscopy, corneal elevation topography (maximum and mean keratometry values, minimum pachymetry, densitometry) and side effects were recorded at baseline and at 1, 3 and 6 months (M).


RESULTS
One hundred and ten eyes of 84 patients were included. At month 6, we found an improvement in corrected distance visual acuity (CDVA) with a small improvment of 0.069±0.15 logMAR (P=0.009). Uncorrected distance visual acuity remained unchanged. The mean minimum corneal pachymetry was 455μm at baseline and 449μm at m6 (P<0.001). There was no statistically significant difference between pre- and postoperative mean keratometry values (M1, M3, M6). We likewise found no difference in maximum keratometry between pre- and postoperative values at M1, M3 and M6 (P>0.1). With regard to safety, we report 1 case of postoperative infectious keratitis and 1 case of anterior non-granulomatous uveitis after treatment in patients without any known past ocular history.


CONCLUSIONS
The results we found in this study after accelerated corneal crosslinking are similar to those with conventional crosslinking protocols published in the literature.


CONCLUSIONS
High irradiance accelerated corneal collagen crosslinking appears to be a reliable and effective therapeutic alternative for progressive keratoconus, allowing for a more brief procedure.
CHU Timone, 264, rue Saint-Pierre, 13385 Marseille, France. Electronic address: nicolas.moineau@ap-hm.fr.
N
N
Moineau
CHU Timone, 264, rue Saint-Pierre, 13385 Marseille, France.
L
L
Sauvan
CHU Timone, 264, rue Saint-Pierre, 13385 Marseille, France.
J
J
Benichou
CHU Timone, 264, rue Saint-Pierre, 13385 Marseille, France.
G
G
Ho Wang Yin
CHU Timone, 264, rue Saint-Pierre, 13385 Marseille, France.
L
L
Hoffart
D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000378:metabolism / Q000627:therapeutic use*; D003315:Cornea / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D063171:Corneal Pachymetry; D019781:Corneal Topography; D003432:Cross-Linking Reagents / Q000627:therapeutic use*; D005260:Female; D005602:France; D006801:Humans; D007640:Keratoconus / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects; D055815:Young Adult
D003432:Cross-Linking Reagents; D003094:Collagen
Accelerated; Accéléré; Collagen; Collagène; Corneal; Cornée; Crosslinking; Haute irradiance; High-irradiance; Keratoconus; Kératôcone